PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34023778-6	2021	PA treatment augmented AMP-activated protein kinase (AMPK) phosphorylation and TGFb1 expression.	patchouli alcohol	0-2	transforming growth factor, beta 1	Mus musculus	79-84
35091686-3	2022	In this study we identified a natural product patchouli alcohol (PTA) as a selective ERbeta agonist which improved the cognitive defects in female APP/PS1 mice, and explore the underlying mechanisms.	patchouli alcohol	65-68	estrogen receptor 1 (alpha)	Mus musculus	85-91
35091686-3	2022	In this study we identified a natural product patchouli alcohol (PTA) as a selective ERbeta agonist which improved the cognitive defects in female APP/PS1 mice, and explore the underlying mechanisms.	patchouli alcohol	65-68	presenilin 1	Mus musculus	151-154
34601002-6	2021	Treatment of C2C12 myocytes and HepG2 cells with PA augmented AMP-activated protein kinase (AMPK) phosphorylation and Sirtuin 1 (SIRT1) expression in a dose-dependent manner.	patchouli alcohol	49-51	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	62-90
34601002-6	2021	Treatment of C2C12 myocytes and HepG2 cells with PA augmented AMP-activated protein kinase (AMPK) phosphorylation and Sirtuin 1 (SIRT1) expression in a dose-dependent manner.	patchouli alcohol	49-51	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	92-96
34601002-6	2021	Treatment of C2C12 myocytes and HepG2 cells with PA augmented AMP-activated protein kinase (AMPK) phosphorylation and Sirtuin 1 (SIRT1) expression in a dose-dependent manner.	patchouli alcohol	49-51	sirtuin 1	Homo sapiens	118-127
34601002-6	2021	Treatment of C2C12 myocytes and HepG2 cells with PA augmented AMP-activated protein kinase (AMPK) phosphorylation and Sirtuin 1 (SIRT1) expression in a dose-dependent manner.	patchouli alcohol	49-51	sirtuin 1	Homo sapiens	129-134
34601002-7	2021	siRNA-mediated suppression of AMPK or SIRT1 mitigated the effects of PA on palmitate-induced inflammation and insulin resistance in C2C12 myocytes and lipid accumulation in HepG2 cells.	patchouli alcohol	69-71	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	30-34
34601002-7	2021	siRNA-mediated suppression of AMPK or SIRT1 mitigated the effects of PA on palmitate-induced inflammation and insulin resistance in C2C12 myocytes and lipid accumulation in HepG2 cells.	patchouli alcohol	69-71	sirtuin 1	Homo sapiens	38-43
34601002-8	2021	Animal experiments demonstrated that PA administration increased AMPK phosphorylation and SIRT1 expression, and ameliorated inflammation, thereby attenuating skeletal muscle insulin resistance and hepatic steatosis in high-fat diet-fed mice.	patchouli alcohol	37-39	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	65-69
34601002-8	2021	Animal experiments demonstrated that PA administration increased AMPK phosphorylation and SIRT1 expression, and ameliorated inflammation, thereby attenuating skeletal muscle insulin resistance and hepatic steatosis in high-fat diet-fed mice.	patchouli alcohol	37-39	sirtuin 1	Mus musculus	90-95
34601002-9	2021	These results denote that PA alleviates skeletal muscle insulin resistance and hepatic steatosis through AMPK/SIRT1-dependent signaling.	patchouli alcohol	26-28	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	105-109
34601002-9	2021	These results denote that PA alleviates skeletal muscle insulin resistance and hepatic steatosis through AMPK/SIRT1-dependent signaling.	patchouli alcohol	26-28	sirtuin 1	Mus musculus	110-115
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	caspase 3	Homo sapiens	257-266
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	poly(ADP-ribose) polymerase 1	Homo sapiens	276-302
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	poly(ADP-ribose) polymerase 1	Homo sapiens	304-308
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	BCL2 associated X, apoptosis regulator	Homo sapiens	314-340
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	BCL2 associated X, apoptosis regulator	Homo sapiens	342-345
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	BCL2 apoptosis regulator	Homo sapiens	393-398
35558260-9	2022	Results: PA inhibited the proliferation, migration, and invasion, and induced the apoptosis of the DU145 and PC-3 cells in a concentration-dependent manner, and was accompanied by mitochondrial membrane potential depolarization, the upregulation of cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) and Bcl-2-associated X protein (Bax), and the downregulation of B-cell lymphoma-2 (Bcl-2), Ki67, and Mcl-1.	patchouli alcohol	9-11	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	411-416
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	NFKB inhibitor alpha	Homo sapiens	114-126
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	RELA proto-oncogene, NF-kB subunit	Homo sapiens	132-135
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	matrix metallopeptidase 2	Homo sapiens	158-187
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	matrix metallopeptidase 7	Homo sapiens	189-194
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	matrix metallopeptidase 9	Homo sapiens	196-201
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	vascular endothelial growth factor A	Homo sapiens	207-241
35558260-10	2022	In relation to the mechanism, PA significantly downregulated the phosphorylation of inhibitor of NF-kappaB alpha (IkappaBalpha) and p65 and the expression of matrix metalloprotein (MMP)-2, MMP-7, MMP-9, and vascular endothelial growth factor (VEGF).	patchouli alcohol	30-32	vascular endothelial growth factor A	Homo sapiens	243-247
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	0-2	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-16
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	0-2	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	32-37
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	0-2	RELA proto-oncogene, NF-kB subunit	Homo sapiens	63-76
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	0-2	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	113-118
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	192-194	RELA proto-oncogene, NF-kB subunit	Homo sapiens	13-16
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	192-194	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	32-37
35558260-11	2022	PA prevented p65 binding to the Mcl-1 promoter by inactivating NF-kappaB p65, downregulated the transcription of Mcl-1, and the silencing of p65 increased the sensitivity of the CRPC cells to PA-induced apoptosis.	patchouli alcohol	192-194	RELA proto-oncogene, NF-kB subunit	Homo sapiens	141-144
35558260-12	2022	The overexpression of Mcl-1 significantly reversed the PA-induced apoptosis of the CRPC cells.	patchouli alcohol	55-57	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	22-27
35558260-14	2022	Conclusions: We found that PA inhibits the growth, migration, and invasion of CRPC cells in vitro and in vivo by inducing an apoptosis mechanism and inhibiting NF-kappaB activity.	patchouli alcohol	27-29	nuclear factor kappa B subunit 1	Homo sapiens	160-169
35091686-6	2022	We first demonstrated that PTA bound to ERbeta with a dissociation constant (KD) of 288.9 +- 35.14 nM in microscale thermophoresis.	patchouli alcohol	27-30	estrogen receptor 1 (alpha)	Mus musculus	40-46
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	13-16	brain derived neurotrophic factor	Mus musculus	188-192
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	13-16	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	193-197
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	13-16	cAMP responsive element binding protein 1	Mus musculus	198-202
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	13-16	catalase	Mus musculus	246-254
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	13-16	B cell leukemia/lymphoma 2	Mus musculus	276-281
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	123-126	brain derived neurotrophic factor	Mus musculus	188-192
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	123-126	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	193-197
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	123-126	cAMP responsive element binding protein 1	Mus musculus	198-202
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	123-126	catalase	Mus musculus	246-254
35091686-8	2022	Furthermore, PTA administration reduced amyloid plaque deposition in the hippocampus by promoting microglial phagocytosis; PTA administration improved synaptic integrity through enhancing BDNF/TrkB/CREB signaling, ameliorated oxidative stress by Catalase level, and regulated Bcl-2 family proteins in the hippocampus.	patchouli alcohol	123-126	B cell leukemia/lymphoma 2	Mus musculus	276-281
34023778-8	2021	Further, PA increased dose-dependently AMPK phosphorylation as along with TGFb1 and cell migration markers expression.	patchouli alcohol	9-11	transforming growth factor, beta 1	Mus musculus	74-79
34023778-9	2021	siRNA for AMPK or TGFb1 abrogated the effects of PA on cell migration and inflammation.	patchouli alcohol	49-51	transforming growth factor, beta 1	Mus musculus	18-23
34023778-10	2021	TGFb1 siRNA mitigated PA-induced expression of cell migration markers.	patchouli alcohol	22-24	transforming growth factor, beta 1	Mus musculus	0-5
34023778-11	2021	These results suggest that PA ameliorates wound healing via AMPK and TGFb1-mediated suppression of inflammation.	patchouli alcohol	27-29	transforming growth factor, beta 1	Mus musculus	69-74
33995095-7	2021	PA also inhibited the nuclear transfection of miR-30b-5p induced by H. pylori, thereby enhancing transcription factor EB function and increasing lysosome activity.	patchouli alcohol	0-2	microRNA 30b	Homo sapiens	46-53
33995095-8	2021	The finding of strongly invasive intracellular H. pylori has great implications for clinical treatment, and PA can act against invasive H. pylori based on the improvement of miR-30b/c mediated xenophagy.	patchouli alcohol	108-110	microRNA 30b	Homo sapiens	174-181
32190080-9	2020	In addition, the perfusion with PA significantly increased the levels of cGMP and expression of mRNA and protein of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS).	patchouli alcohol	32-34	nitric oxide synthase 1	Rattus norvegicus	116-146
32244196-4	2020	In addition, PA markedly attenuated CUMS-induced mTOR, p70S6K, and 4E-BP-1 phosphorylation reduction in the hippocampus.	patchouli alcohol	13-15	mechanistic target of rapamycin kinase	Rattus norvegicus	49-53
32244196-6	2020	These results indicated that the antidepressant-like effect of PA was correlated with the activation of the mTOR signaling pathway.	patchouli alcohol	63-65	mechanistic target of rapamycin kinase	Rattus norvegicus	108-112
32244196-7	2020	Moreover, behavioral experimental results showed that the antidepressant-like effect of PA was blocked by rapamycin (autophagy inducer and mTOR inhibitor) and chloroquine (autophagic flux inhibitor).	patchouli alcohol	88-90	mechanistic target of rapamycin kinase	Rattus norvegicus	139-143
32244196-8	2020	These results suggest that PA exerted antidepressant-like effect in CUMS rats through inhibiting autophagy, repairing synapse, and restoring autophagic flux in the hippocampus by activating the mTOR signaling pathway.	patchouli alcohol	27-29	mechanistic target of rapamycin kinase	Rattus norvegicus	194-198
32190080-9	2020	In addition, the perfusion with PA significantly increased the levels of cGMP and expression of mRNA and protein of neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS).	patchouli alcohol	32-34	nitric oxide synthase 1	Rattus norvegicus	148-152
28795389-3	2019	Intracellular calcium ion was imaged to verify PA on mu-opioid receptor (MOR).	patchouli alcohol	47-49	opioid receptor, mu 1	Mus musculus	73-76
31614203-12	2020	PA prevented DSS-induced inflammation by regulating PXR/NF-kappaB signalling, whereas pharmacological PXR inhibition abated PA-mediated suppressive effects on NF-kappaB inflammation signalling.	patchouli alcohol	124-126	nuclear receptor subfamily 1 group I member 2	Homo sapiens	102-105
31614203-13	2020	CONCLUSIONS: PA activates PXR signalling and suppresses NF-kappaB signalling, consequently causing amelioration of inflammation.	patchouli alcohol	13-15	nuclear receptor subfamily 1 group I member 2	Homo sapiens	26-29
31614203-3	2020	AIM OF THE STUDY: The aim of the present study was to investigate the anti-inflammatory effect of PA, primarily focused on crosstalk between PA-mediated PXR activation and NF-kappaB inhibition.	patchouli alcohol	98-100	nuclear receptor subfamily 1 group I member 2	Homo sapiens	153-156
31614203-3	2020	AIM OF THE STUDY: The aim of the present study was to investigate the anti-inflammatory effect of PA, primarily focused on crosstalk between PA-mediated PXR activation and NF-kappaB inhibition.	patchouli alcohol	141-143	nuclear receptor subfamily 1 group I member 2	Homo sapiens	153-156
31614203-4	2020	MATERIALS AND METHODS: We evaluated the anti-inflammatory effect of PA with respect to PXR/NF-kappaB signalling using in vitro and in vivo models.	patchouli alcohol	68-70	nuclear receptor subfamily 1 group I member 2	Homo sapiens	87-90
31614203-5	2020	In vitro, PA, identified as a PXR agonist, was evaluated by hPXR transactivation assays and through assessing for CYP3A4 expression and activity.	patchouli alcohol	10-12	nuclear receptor subfamily 1 group I member 2	Homo sapiens	30-33
31614203-5	2020	In vitro, PA, identified as a PXR agonist, was evaluated by hPXR transactivation assays and through assessing for CYP3A4 expression and activity.	patchouli alcohol	10-12	nuclear receptor subfamily 1 group I member 2	Homo sapiens	60-64
31614203-8	2020	Furthermore, pharmacological inhibition of PXR was further evaluated by examining PA protection against DSS-induced colitis.	patchouli alcohol	82-84	nuclear receptor subfamily 1 group I member 2	Homo sapiens	43-46
31614203-9	2020	RESULTS: PA induced CYP3A4 expression and activity via an hPXR-dependent mechanism.	patchouli alcohol	9-11	nuclear receptor subfamily 1 group I member 2	Homo sapiens	58-62
31614203-10	2020	PA-mediated PXR activation attenuated inflammation by inhibiting NF-kappaB activity and nuclear translocation.	patchouli alcohol	0-2	nuclear receptor subfamily 1 group I member 2	Homo sapiens	12-15
31614203-11	2020	The anti-inflammatory effect of PA on NF-kappaB was abolished by PXR knockdown.	patchouli alcohol	32-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	65-68
31614203-12	2020	PA prevented DSS-induced inflammation by regulating PXR/NF-kappaB signalling, whereas pharmacological PXR inhibition abated PA-mediated suppressive effects on NF-kappaB inflammation signalling.	patchouli alcohol	0-2	nuclear receptor subfamily 1 group I member 2	Homo sapiens	52-55
28795389-5	2019	Cellular experiments were carried out to find out COX2 and MOR expression induced by PA.	patchouli alcohol	85-87	prostaglandin-endoperoxide synthase 2	Mus musculus	50-54
28795389-5	2019	Cellular experiments were carried out to find out COX2 and MOR expression induced by PA.	patchouli alcohol	85-87	opioid receptor, mu 1	Mus musculus	59-62
28795389-7	2019	PA also up-regulated COX2 mRNA and protein (P<0.05) with a down-regulation of MOR (P<0.05) both in in vivo and in vitro experiments, which devote to the analgesic effect of PA.	patchouli alcohol	0-2	prostaglandin-endoperoxide synthase 2	Mus musculus	21-25
28795389-7	2019	PA also up-regulated COX2 mRNA and protein (P<0.05) with a down-regulation of MOR (P<0.05) both in in vivo and in vitro experiments, which devote to the analgesic effect of PA.	patchouli alcohol	0-2	opioid receptor, mu 1	Mus musculus	81-84
28795389-9	2019	PA showed the characters of enhancing the MOR expression and reducing the intracellular calcium ion similar to opioid effect.	patchouli alcohol	0-2	opioid receptor, mu 1	Mus musculus	42-45
28795389-10	2019	CONCLUSIONS: Both COX2 and MOR are involved in the mechanism of PA"s anti-nociceptive effect, and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA"s effect on MOR.	patchouli alcohol	64-66	prostaglandin-endoperoxide synthase 2	Mus musculus	18-22
28795389-10	2019	CONCLUSIONS: Both COX2 and MOR are involved in the mechanism of PA"s anti-nociceptive effect, and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA"s effect on MOR.	patchouli alcohol	64-66	opioid receptor, mu 1	Mus musculus	27-30
28795389-10	2019	CONCLUSIONS: Both COX2 and MOR are involved in the mechanism of PA"s anti-nociceptive effect, and the up-regulation of the receptor expression and the inhibition of intracellular calcium are a new perspective to PA"s effect on MOR.	patchouli alcohol	212-214	opioid receptor, mu 1	Mus musculus	227-230
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	mast cell protease 1	Mus musculus	71-76
28456683-10	2017	Furthermore, PA improved the intestinal epithelial barrier by enhancing the level of colonic expression of the tight junction (TJ) proteins, for instance ZO-1, ZO-2, claudin-1 and occludin, and by elevating the levels of mucin-1 and mucin-2 mRNA.	patchouli alcohol	13-15	tight junction protein 1	Mus musculus	154-158
28456683-10	2017	Furthermore, PA improved the intestinal epithelial barrier by enhancing the level of colonic expression of the tight junction (TJ) proteins, for instance ZO-1, ZO-2, claudin-1 and occludin, and by elevating the levels of mucin-1 and mucin-2 mRNA.	patchouli alcohol	13-15	tight junction protein 2	Mus musculus	160-164
28456683-10	2017	Furthermore, PA improved the intestinal epithelial barrier by enhancing the level of colonic expression of the tight junction (TJ) proteins, for instance ZO-1, ZO-2, claudin-1 and occludin, and by elevating the levels of mucin-1 and mucin-2 mRNA.	patchouli alcohol	13-15	claudin 1	Mus musculus	166-175
28456683-10	2017	Furthermore, PA improved the intestinal epithelial barrier by enhancing the level of colonic expression of the tight junction (TJ) proteins, for instance ZO-1, ZO-2, claudin-1 and occludin, and by elevating the levels of mucin-1 and mucin-2 mRNA.	patchouli alcohol	13-15	occludin	Mus musculus	180-188
28456683-10	2017	Furthermore, PA improved the intestinal epithelial barrier by enhancing the level of colonic expression of the tight junction (TJ) proteins, for instance ZO-1, ZO-2, claudin-1 and occludin, and by elevating the levels of mucin-1 and mucin-2 mRNA.	patchouli alcohol	13-15	mucin 1, transmembrane	Mus musculus	221-228
28456683-10	2017	Furthermore, PA improved the intestinal epithelial barrier by enhancing the level of colonic expression of the tight junction (TJ) proteins, for instance ZO-1, ZO-2, claudin-1 and occludin, and by elevating the levels of mucin-1 and mucin-2 mRNA.	patchouli alcohol	13-15	mucin 2	Mus musculus	233-240
28456683-11	2017	The study also demonstrated that PA inhibited the DSS-induced cell death signaling by modulating the apoptosis related Bax and Bcl-2 proteins and down-regulating the necroptosis related RIP3 and MLKL proteins.	patchouli alcohol	33-35	BCL2-associated X protein	Mus musculus	119-122
28456683-11	2017	The study also demonstrated that PA inhibited the DSS-induced cell death signaling by modulating the apoptosis related Bax and Bcl-2 proteins and down-regulating the necroptosis related RIP3 and MLKL proteins.	patchouli alcohol	33-35	B cell leukemia/lymphoma 2	Mus musculus	127-132
28456683-11	2017	The study also demonstrated that PA inhibited the DSS-induced cell death signaling by modulating the apoptosis related Bax and Bcl-2 proteins and down-regulating the necroptosis related RIP3 and MLKL proteins.	patchouli alcohol	33-35	receptor-interacting serine-threonine kinase 3	Mus musculus	186-190
28456683-11	2017	The study also demonstrated that PA inhibited the DSS-induced cell death signaling by modulating the apoptosis related Bax and Bcl-2 proteins and down-regulating the necroptosis related RIP3 and MLKL proteins.	patchouli alcohol	33-35	mixed lineage kinase domain-like	Mus musculus	195-199
28456683-12	2017	By comparison, up-regulation of IDO-1 and TPH-1 protein expression in DSS group was suppressed by PA, which was in line with the declined levels of kynurenine (Kyn) and 5-hydroxytryptophan (5-HTP) in plasma.	patchouli alcohol	98-100	indoleamine 2,3-dioxygenase 1	Mus musculus	32-37
28456683-12	2017	By comparison, up-regulation of IDO-1 and TPH-1 protein expression in DSS group was suppressed by PA, which was in line with the declined levels of kynurenine (Kyn) and 5-hydroxytryptophan (5-HTP) in plasma.	patchouli alcohol	98-100	tryptophan hydroxylase 1	Mus musculus	42-47
29291393-8	2018	PA treatment alleviated BBB dysfunction, inhibited mRNA and protein levels of TNF-alpha and IL-1beta and modulated the activation of MAPKs signaling pathways.	patchouli alcohol	0-2	tumor necrosis factor	Mus musculus	78-87
29291393-8	2018	PA treatment alleviated BBB dysfunction, inhibited mRNA and protein levels of TNF-alpha and IL-1beta and modulated the activation of MAPKs signaling pathways.	patchouli alcohol	0-2	interleukin 1 beta	Mus musculus	92-100
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	nitric oxide synthase 2, inducible	Mus musculus	78-82
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	interleukin 1 beta	Mus musculus	84-92
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	interleukin 6	Mus musculus	94-98
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	chemokine (C-X-C motif) ligand 9	Mus musculus	100-105
27522255-7	2016	Aortic mRNA expression of macrophage inflammatory cytokines, including MCP-1, iNOS, IL-1beta, IL-6, CXCL9 and CXCL11, was also reduced in PA-treated mice.	patchouli alcohol	138-140	chemokine (C-X-C motif) ligand 11	Mus musculus	110-116
23602914-6	2013	In addition, PA decreased cell growth in MCF7, BxPC3, PC3, and HUVEC cells.	patchouli alcohol	13-15	proprotein convertase subtilisin/kexin type 1	Homo sapiens	49-52
25033712-6	2014	Our findings amply demonstrated that PA significantly accelerated the recovery of the UV-induced skin lesions, evidently through anti-oxidant and anti-inflammatory action, as well as down-regulation of the MMP-1 and MMP-3 expression.	patchouli alcohol	37-39	matrix metallopeptidase 13	Mus musculus	206-211
25033712-6	2014	Our findings amply demonstrated that PA significantly accelerated the recovery of the UV-induced skin lesions, evidently through anti-oxidant and anti-inflammatory action, as well as down-regulation of the MMP-1 and MMP-3 expression.	patchouli alcohol	37-39	matrix metallopeptidase 3	Mus musculus	216-221
25168850-7	2014	PA pretreatment significantly promoted gastric prostaglandin E2 (PGE2) and non-protein sulfhydryl group (NP-SH) levels, upregulated the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) mRNA expression, and considerably boosted the gastric blood flow (GBF) and gastric mucus production in comparison with vehicle.	patchouli alcohol	0-2	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	136-152
25168850-7	2014	PA pretreatment significantly promoted gastric prostaglandin E2 (PGE2) and non-protein sulfhydryl group (NP-SH) levels, upregulated the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) mRNA expression, and considerably boosted the gastric blood flow (GBF) and gastric mucus production in comparison with vehicle.	patchouli alcohol	0-2	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	154-159
25168850-7	2014	PA pretreatment significantly promoted gastric prostaglandin E2 (PGE2) and non-protein sulfhydryl group (NP-SH) levels, upregulated the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) mRNA expression, and considerably boosted the gastric blood flow (GBF) and gastric mucus production in comparison with vehicle.	patchouli alcohol	0-2	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	165-181
25168850-7	2014	PA pretreatment significantly promoted gastric prostaglandin E2 (PGE2) and non-protein sulfhydryl group (NP-SH) levels, upregulated the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) mRNA expression, and considerably boosted the gastric blood flow (GBF) and gastric mucus production in comparison with vehicle.	patchouli alcohol	0-2	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	183-188
25168850-8	2014	In addition, PA modulated the levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha).	patchouli alcohol	13-15	interleukin 6	Rattus norvegicus	40-53
25168850-8	2014	In addition, PA modulated the levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha).	patchouli alcohol	13-15	interleukin 6	Rattus norvegicus	55-59
25168850-8	2014	In addition, PA modulated the levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha).	patchouli alcohol	13-15	interleukin 10	Rattus norvegicus	62-76
25168850-8	2014	In addition, PA modulated the levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha).	patchouli alcohol	13-15	interleukin 10	Rattus norvegicus	78-83
25168850-8	2014	In addition, PA modulated the levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha).	patchouli alcohol	13-15	tumor necrosis factor	Rattus norvegicus	89-116
25168850-8	2014	In addition, PA modulated the levels of interleukin-6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha).	patchouli alcohol	13-15	tumor necrosis factor	Rattus norvegicus	118-127
25168850-9	2014	The levels of glutathione (GSH), catalase (CAT) and malonaldehyde (MDA) were also restored by PA.	patchouli alcohol	94-96	catalase	Rattus norvegicus	33-41
25168850-9	2014	The levels of glutathione (GSH), catalase (CAT) and malonaldehyde (MDA) were also restored by PA.	patchouli alcohol	94-96	catalase	Rattus norvegicus	43-46
27056378-10	2016	Compared with the heat shock group alone, PA pretreatment significantly decreased the mRNA expression by HSP70, HSP90, SOD, CAT, GSH-px, KEAP1 and HO-1.	patchouli alcohol	42-44	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	105-110
27056378-10	2016	Compared with the heat shock group alone, PA pretreatment significantly decreased the mRNA expression by HSP70, HSP90, SOD, CAT, GSH-px, KEAP1 and HO-1.	patchouli alcohol	42-44	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	112-117
27056378-10	2016	Compared with the heat shock group alone, PA pretreatment significantly decreased the mRNA expression by HSP70, HSP90, SOD, CAT, GSH-px, KEAP1 and HO-1.	patchouli alcohol	42-44	catalase	Rattus norvegicus	124-127
27056378-10	2016	Compared with the heat shock group alone, PA pretreatment significantly decreased the mRNA expression by HSP70, HSP90, SOD, CAT, GSH-px, KEAP1 and HO-1.	patchouli alcohol	42-44	Kelch-like ECH-associated protein 1	Rattus norvegicus	137-142
27056378-10	2016	Compared with the heat shock group alone, PA pretreatment significantly decreased the mRNA expression by HSP70, HSP90, SOD, CAT, GSH-px, KEAP1 and HO-1.	patchouli alcohol	42-44	heme oxygenase 1	Rattus norvegicus	147-151
27056378-11	2016	Furthermore, the high dose of PA significantly increased Nrf2 protein expression, while both the intermediate and high dose of PA significantly increased HO-1 protein expression.	patchouli alcohol	30-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
27056378-11	2016	Furthermore, the high dose of PA significantly increased Nrf2 protein expression, while both the intermediate and high dose of PA significantly increased HO-1 protein expression.	patchouli alcohol	127-129	heme oxygenase 1	Rattus norvegicus	154-158
24839088-7	2014	The results showed that PA inhibited the LPS-induced TNF-alpha, IL-6, and IL-1beta production in a dose manner.	patchouli alcohol	24-26	tumor necrosis factor	Mus musculus	53-62
24839088-7	2014	The results showed that PA inhibited the LPS-induced TNF-alpha, IL-6, and IL-1beta production in a dose manner.	patchouli alcohol	24-26	interleukin 6	Mus musculus	64-68
24839088-7	2014	The results showed that PA inhibited the LPS-induced TNF-alpha, IL-6, and IL-1beta production in a dose manner.	patchouli alcohol	24-26	interleukin 1 beta	Mus musculus	74-82
23602914-7	2013	Exposure of PA to HCT116 and SW480 cells activated p21 expression and suppressed the expressions of cyclin D1 and cyclin-dependent kinase 4 (CDK4) in a dose-dependent manner.	patchouli alcohol	12-14	H3 histone pseudogene 16	Homo sapiens	51-54
23602914-7	2013	Exposure of PA to HCT116 and SW480 cells activated p21 expression and suppressed the expressions of cyclin D1 and cyclin-dependent kinase 4 (CDK4) in a dose-dependent manner.	patchouli alcohol	12-14	cyclin D1	Homo sapiens	100-109
23602914-7	2013	Exposure of PA to HCT116 and SW480 cells activated p21 expression and suppressed the expressions of cyclin D1 and cyclin-dependent kinase 4 (CDK4) in a dose-dependent manner.	patchouli alcohol	12-14	cyclin dependent kinase 4	Homo sapiens	114-139
23602914-7	2013	Exposure of PA to HCT116 and SW480 cells activated p21 expression and suppressed the expressions of cyclin D1 and cyclin-dependent kinase 4 (CDK4) in a dose-dependent manner.	patchouli alcohol	12-14	cyclin dependent kinase 4	Homo sapiens	141-145
23602914-8	2013	In addition, PA attenuated the expressions of HDAC2 (histone deacetylase 2) and c-myc, and HDAC enzyme activity.	patchouli alcohol	13-15	histone deacetylase 2	Homo sapiens	46-51
23602914-8	2013	In addition, PA attenuated the expressions of HDAC2 (histone deacetylase 2) and c-myc, and HDAC enzyme activity.	patchouli alcohol	13-15	histone deacetylase 2	Homo sapiens	53-74
23602914-8	2013	In addition, PA attenuated the expressions of HDAC2 (histone deacetylase 2) and c-myc, and HDAC enzyme activity.	patchouli alcohol	13-15	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	80-85
23602914-9	2013	We also observed that PA induced the transcriptional activity of NF-kappaB through an increase of nuclear translocation of p65.	patchouli alcohol	22-24	nuclear factor kappa B subunit 1	Homo sapiens	65-74
23602914-9	2013	We also observed that PA induced the transcriptional activity of NF-kappaB through an increase of nuclear translocation of p65.	patchouli alcohol	22-24	RELA proto-oncogene, NF-kB subunit	Homo sapiens	123-126
21958968-6	2011	In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-alpha, IL-1beta, PGE2 and NO in the hind paw of carrageenan-treated rats.	patchouli alcohol	28-30	tumor necrosis factor	Rattus norvegicus	95-104
23348408-4	2013	In this study, we investigated whether PA decreases the production of inflammatory mediators through downregulation of the NF-kappaB and ERK pathway.	patchouli alcohol	39-41	mitogen-activated protein kinase 1	Homo sapiens	137-140
23348408-5	2013	Our data indicated that PA inhibits the over-expression of iNOS and IL-6 in protein and mRNA levels in LPS-stimulated RAW264.7 and TNF-alpha stimulated HT-29 cells.	patchouli alcohol	24-26	nitric oxide synthase 2, inducible	Mus musculus	59-63
23348408-5	2013	Our data indicated that PA inhibits the over-expression of iNOS and IL-6 in protein and mRNA levels in LPS-stimulated RAW264.7 and TNF-alpha stimulated HT-29 cells.	patchouli alcohol	24-26	interleukin 6	Mus musculus	68-72
23348408-5	2013	Our data indicated that PA inhibits the over-expression of iNOS and IL-6 in protein and mRNA levels in LPS-stimulated RAW264.7 and TNF-alpha stimulated HT-29 cells.	patchouli alcohol	24-26	tumor necrosis factor	Mus musculus	131-140
23348408-6	2013	PA inhibited IkappaB-alpha degradation and p65 nuclear translocation, and subsequently suppressed transcriptional activity of NF-kappaB in LPS-stimulated RAW264.7 and TNF-alpha-stimulated HT-29 cells.	patchouli alcohol	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	13-26
23348408-6	2013	PA inhibited IkappaB-alpha degradation and p65 nuclear translocation, and subsequently suppressed transcriptional activity of NF-kappaB in LPS-stimulated RAW264.7 and TNF-alpha-stimulated HT-29 cells.	patchouli alcohol	0-2	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	43-46
23348408-6	2013	PA inhibited IkappaB-alpha degradation and p65 nuclear translocation, and subsequently suppressed transcriptional activity of NF-kappaB in LPS-stimulated RAW264.7 and TNF-alpha-stimulated HT-29 cells.	patchouli alcohol	0-2	tumor necrosis factor	Mus musculus	167-176
23348408-7	2013	In addition, PA inhibited LPS- or TNF-alpha-stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2.	patchouli alcohol	13-15	tumor necrosis factor	Homo sapiens	34-43
23348408-7	2013	In addition, PA inhibited LPS- or TNF-alpha-stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2.	patchouli alcohol	13-15	mitogen-activated protein kinase 3	Homo sapiens	55-61
23348408-7	2013	In addition, PA inhibited LPS- or TNF-alpha-stimulated ERK1/2 activation by decreasing phosphorylation of ERK1/2.	patchouli alcohol	13-15	mitogen-activated protein kinase 3	Homo sapiens	106-112
23348408-8	2013	These findings suggest that PA shows anti-inflammatory activities through suppressing ERK-mediated NF-kappaB pathway in mouse macrophage and human colorectal cancer cells.	patchouli alcohol	28-30	mitogen-activated protein kinase 1	Mus musculus	86-89
21958968-6	2011	In addition, treatment with PA (10-40 mg/kg) also dose-dependently decreased the production of TNF-alpha, IL-1beta, PGE2 and NO in the hind paw of carrageenan-treated rats.	patchouli alcohol	28-30	interleukin 1 beta	Rattus norvegicus	106-114
21958968-7	2011	Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats.	patchouli alcohol	13-15	tumor necrosis factor	Rattus norvegicus	65-74
21958968-7	2011	Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats.	patchouli alcohol	13-15	interleukin 1 beta	Rattus norvegicus	76-84
21958968-7	2011	Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats.	patchouli alcohol	13-15	nitric oxide synthase 2	Rattus norvegicus	86-117
21958968-7	2011	Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats.	patchouli alcohol	13-15	nitric oxide synthase 2	Rattus norvegicus	119-123
21958968-7	2011	Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats.	patchouli alcohol	13-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	129-145
21958968-7	2011	Furthermore, PA treatment also suppressed the mRNA expression of TNF-alpha, IL-1beta, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the hind paw of carrageenan-treated rats.	patchouli alcohol	13-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	147-152
21958968-8	2011	These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1beta, iNOS and COX-2.	patchouli alcohol	27-29	tumor necrosis factor	Rattus norvegicus	202-211
21958968-8	2011	These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1beta, iNOS and COX-2.	patchouli alcohol	27-29	interleukin 1 beta	Rattus norvegicus	213-221
21958968-8	2011	These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1beta, iNOS and COX-2.	patchouli alcohol	27-29	nitric oxide synthase 2	Rattus norvegicus	223-227
21958968-8	2011	These results suggest that PA possesses potent anti-inflammatory activity, which may be mediated, at least in part, by down-regulating the mRNA expression of a panel of inflammatory mediators including TNF-alpha, IL-1beta, iNOS and COX-2.	patchouli alcohol	27-29	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	232-237
22977538-4	2011	Pre-treatment with PA at concentrations of 10, 20 or 40 muM dose-dependently decreased the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, nitric oxide (NO) and prostaglandin E(2) in LPS-stimulated RAW264.7 cells.	patchouli alcohol	19-21	tumor necrosis factor	Mus musculus	105-138
22977538-4	2011	Pre-treatment with PA at concentrations of 10, 20 or 40 muM dose-dependently decreased the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, nitric oxide (NO) and prostaglandin E(2) in LPS-stimulated RAW264.7 cells.	patchouli alcohol	19-21	interleukin 1 beta	Mus musculus	140-162
22977538-6	2011	These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1beta, IL-6, iNOS and COX-2.	patchouli alcohol	28-30	cytochrome c oxidase II, mitochondrial	Mus musculus	296-301
22977538-4	2011	Pre-treatment with PA at concentrations of 10, 20 or 40 muM dose-dependently decreased the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, nitric oxide (NO) and prostaglandin E(2) in LPS-stimulated RAW264.7 cells.	patchouli alcohol	19-21	interleukin 6	Mus musculus	164-168
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	tumor necrosis factor	Mus musculus	73-82
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	interleukin 1 beta	Mus musculus	84-92
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	interleukin 6	Mus musculus	94-98
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	nitric oxide synthase 2, inducible	Mus musculus	100-131
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	nitric oxide synthase 2, inducible	Mus musculus	133-137
22977538-5	2011	In addition, PA treatment also reversed the increased mRNA expression of TNF-alpha, IL-1beta, IL-6, inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 caused by LPS in RAW264.7 cells.	patchouli alcohol	13-15	cytochrome c oxidase II, mitochondrial	Mus musculus	143-165
22977538-6	2011	These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1beta, IL-6, iNOS and COX-2.	patchouli alcohol	28-30	tumor necrosis factor	Mus musculus	260-269
22977538-6	2011	These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1beta, IL-6, iNOS and COX-2.	patchouli alcohol	28-30	interleukin 1 beta	Mus musculus	271-279
22977538-6	2011	These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1beta, IL-6, iNOS and COX-2.	patchouli alcohol	28-30	interleukin 6	Mus musculus	281-285
22977538-6	2011	These results indicate that PA is an important anti-inflammatory constituent of Pogostemonis Herba and that its anti-inflammatory effect may be mediated, at least in part, by down-regulation of the mRNA expression of a panel of inflammatory mediators, such as TNF-alpha, IL-1beta, IL-6, iNOS and COX-2.	patchouli alcohol	28-30	nitric oxide synthase 2, inducible	Mus musculus	287-291
17705244-7	2008	Thus, the final titer of patchoulol and farnesol in the ERG9 downregulated strain reached 16.9 and 20.2 mg/L, respectively.	patchouli alcohol	25-35	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	56-60