PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34027766-8	2021	MiR-429 was downregulated whereas PDCD4 was upregulated in contrast media iodixanol-stimulated HK-2 cells.	iodixanol	74-83	programmed cell death 4	Homo sapiens	34-39
33658920-10	2020	Iodixanol impaired cell viability, promoted vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1) expression, and induced cell apoptosis in human umbilical vein endothelial cells (HUVECs).	iodixanol	0-9	vascular cell adhesion molecule 1	Homo sapiens	44-77
33658920-10	2020	Iodixanol impaired cell viability, promoted vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1) expression, and induced cell apoptosis in human umbilical vein endothelial cells (HUVECs).	iodixanol	0-9	vascular cell adhesion molecule 1	Homo sapiens	79-85
33658920-10	2020	Iodixanol impaired cell viability, promoted vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1) expression, and induced cell apoptosis in human umbilical vein endothelial cells (HUVECs).	iodixanol	0-9	intercellular adhesion molecule 1	Homo sapiens	91-129
33658920-10	2020	Iodixanol impaired cell viability, promoted vascular cell adhesion molecule-1 (VCAM-1) and intercellular cell adhesion molecule-1 (ICAM-1) expression, and induced cell apoptosis in human umbilical vein endothelial cells (HUVECs).	iodixanol	0-9	intercellular adhesion molecule 1	Homo sapiens	131-137
33658920-12	2020	Furthermore, iodixanol induced the phosphorylation of protein kinase C (PKC) beta II, p47, Rac1, and endothelial nitric oxide synthase (eNOS) at Thr495, which elicited ROS release and ONOO- generation.	iodixanol	13-22	pleckstrin	Homo sapiens	86-89
33658920-12	2020	Furthermore, iodixanol induced the phosphorylation of protein kinase C (PKC) beta II, p47, Rac1, and endothelial nitric oxide synthase (eNOS) at Thr495, which elicited ROS release and ONOO- generation.	iodixanol	13-22	Rac family small GTPase 1	Homo sapiens	91-95
33658920-12	2020	Furthermore, iodixanol induced the phosphorylation of protein kinase C (PKC) beta II, p47, Rac1, and endothelial nitric oxide synthase (eNOS) at Thr495, which elicited ROS release and ONOO- generation.	iodixanol	13-22	nitric oxide synthase 3	Homo sapiens	101-134
33658920-12	2020	Furthermore, iodixanol induced the phosphorylation of protein kinase C (PKC) beta II, p47, Rac1, and endothelial nitric oxide synthase (eNOS) at Thr495, which elicited ROS release and ONOO- generation.	iodixanol	13-22	nitric oxide synthase 3	Homo sapiens	136-140
31770751-1	2021	INTRODUCTION: A few reports stating that differences in the various types of contrast media injected into the pancreatic duct are related to the onset of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been published, and it was indicated that iodixanol which is a nonionic iodide radiographic contrast medium with a dimeric (2 dimers) structure may reduce the incidence of PEP.	iodixanol	279-288	progestagen associated endometrial protein	Homo sapiens	227-230
32014904-8	2020	Iodixanol-induced inflammatory cytokines TNFa and IL-6 and inflammatory genes Nrf2 and ICAM-1 were reduced by ELA32 treatment (p<0.01).	iodixanol	0-9	tumor necrosis factor	Homo sapiens	41-45
32798557-0	2020	Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway.	iodixanol	43-52	mechanistic target of rapamycin kinase	Rattus norvegicus	90-94
32798557-0	2020	Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway.	iodixanol	43-52	ribosomal protein S6 kinase B1	Rattus norvegicus	95-101
32798557-12	2020	SIGNIFICANCE: Rapamycin can alleviate renal injury induced by Iodixanol diabetic rats, and its regulatory mechanisms may be related to the regulation of mTOR/p70S6K signaling pathway and the activating autophagy.	iodixanol	62-71	ribosomal protein S6 kinase B1	Rattus norvegicus	158-164
32517090-8	2020	Pretreatment with compound 8 reversed iodixanol-induced increases in the expression of JNK, ERK, p38, Bax, caspase-3, and caspase-9.	iodixanol	38-47	caspase 3	Sus scrofa	107-116
32517090-10	2020	Furthermore, pretreatment with compound 8 caused nuclear translocation of Nrf2 and upregulated HO-1 via the Nrf2 pathway in iodixanol-treated LLC-PK1 cells.	iodixanol	124-133	heme oxygenase 1	Sus scrofa	95-99
32517090-11	2020	Thus, we demonstrated here that compound 8 isolated from A. argyi has the potential to effectively prevent iodixanol-induced kidney epithelial cell death via the caspase-3/MAPK pathways and HO-1 via the Nrf2 pathway.	iodixanol	107-116	caspase 3	Sus scrofa	162-171
32014904-8	2020	Iodixanol-induced inflammatory cytokines TNFa and IL-6 and inflammatory genes Nrf2 and ICAM-1 were reduced by ELA32 treatment (p<0.01).	iodixanol	0-9	interleukin 6	Homo sapiens	50-54
32014904-8	2020	Iodixanol-induced inflammatory cytokines TNFa and IL-6 and inflammatory genes Nrf2 and ICAM-1 were reduced by ELA32 treatment (p<0.01).	iodixanol	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
32014904-8	2020	Iodixanol-induced inflammatory cytokines TNFa and IL-6 and inflammatory genes Nrf2 and ICAM-1 were reduced by ELA32 treatment (p<0.01).	iodixanol	0-9	intercellular adhesion molecule 1	Homo sapiens	87-93
32014904-10	2020	ELA32 treatment suppressed iodixanol-induced up-regulation of DNA damage-associated gene P-ATR and p-CHK1 as well as apoptosis-associated gene C-caspase 3 (p<0.05).	iodixanol	27-36	checkpoint kinase 1	Homo sapiens	101-105
32036364-3	2020	OBJECTIVE: The aim of this study was to investigate clinical (contrast-induced acute kidney injury [CI-AKI]) and subclinical CI-AKI (SCI-AKI) after intra-arterial administration of Iodixanol and Iopamidol in patients with an estimated glomerular filtration rate (eGFR) >=60 mL/min/1.73 m2.	iodixanol	181-190	CD59 molecule (CD59 blood group)	Homo sapiens	277-282
29074393-6	2018	An iodixanol step gradient further confirmed that DCF1 is localized to the mitochondria, endosomes, lysosomes, endoplasmic reticulum, and proteasome.	iodixanol	3-12	transmembrane protein 59	Homo sapiens	50-54
30924055-11	2019	Similarly, the results showed significant differences in P-glycoprotein function of K562/Dox cancer cells after treatment with IRCM when compared to the non-treated K562/Dox cancer cells, with iohexol and iodixanol being the notable exceptions once again.	iodixanol	205-214	ATP binding cassette subfamily B member 1	Homo sapiens	57-71
29860548-7	2018	Of note, iodixanol appeared to induce a stronger activation of mitophagy than iohexol, evidenced by greater protein levels of LC3II and PINK1/Parkin in the renal tissue of iodixanol-treated rats.	iodixanol	9-18	PTEN induced kinase 1	Rattus norvegicus	136-141
29860548-7	2018	Of note, iodixanol appeared to induce a stronger activation of mitophagy than iohexol, evidenced by greater protein levels of LC3II and PINK1/Parkin in the renal tissue of iodixanol-treated rats.	iodixanol	172-181	PTEN induced kinase 1	Rattus norvegicus	136-141
31517418-3	2019	MATERIALS AND METHODS: We have developed and optimized a rapid iodixanol (OptiPrep)-based gradient centrifugation system to identify, isolate and characterize doxorubicin (DXR)-induced senescent hepatocellular carcinoma (HCC) cells (HepG2 and Huh-7) in vitro.	iodixanol	74-82	MIR7-3 host gene	Homo sapiens	243-248
31493196-2	2019	MATERIALS AND METHODS: SAP-MS were suspended in contrast material (iodixanol) and the diameter change was assessed.	iodixanol	67-76	SH2 domain containing 1A	Homo sapiens	23-26
26606891-12	2016	Iodixanol density gradient analysis revealed that the peak fraction of infectivity titer was eliminated by LL-37 treatment.	iodixanol	0-9	cathelicidin antimicrobial peptide	Homo sapiens	107-112
28731176-8	2017	Both iopamidol and iodixanol treatments deceased cell viability and increased apoptosis of HUVEC and H5V cells, along with downregulated NOS and ABCG1.	iodixanol	19-28	ATP binding cassette subfamily G member 1	Mus musculus	145-150
28731176-9	2017	The injection of iopamidol or iodixanol into rats changed the endothelium-related plasma levels of biomarkers, including endothelin, von Willebrand factor, tissue type plasminogen activator, plasminogen activator inhibitor, D-Dimer, fibrinogen and anti-thrombin III.	iodixanol	30-39	coagulation factor II	Rattus norvegicus	253-261
27293071-4	2016	Iodixanol treatment increased the phosphorylation of p38, ERK and cleavage of caspase-3 in LLC-PK1 cells, which were significantly decreased by co-treatment with alpha-mangostin (2.5 and 5muM).	iodixanol	0-9	caspase 3	Sus scrofa	78-87
26784323-6	2016	OUTCOME: Plasma t-PA antigen was depressed equally in the study groups after angiography, but there was a greater reduction in PAI-1 antigen in the group receiving iodixanol.	iodixanol	164-173	serpin family E member 1	Homo sapiens	127-132
25411339-6	2015	Both endogenous and exogenously expressed ERManI migrate at an ER-like density on iodixanol gradients, suggesting that the QCVs are derived from the ER.	iodixanol	82-91	mannosidase alpha class 1B member 1	Homo sapiens	42-48
26317805-6	2015	Furthermore, the fraction of p25 prepared from iodixanol gradient centrifugation was unexpectedly protected by protease digestion, suggesting that p25/Cdk5-mediated BACE1 phosphorylation may occur in the lumen.	iodixanol	47-56	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	29-32
26317805-6	2015	Furthermore, the fraction of p25 prepared from iodixanol gradient centrifugation was unexpectedly protected by protease digestion, suggesting that p25/Cdk5-mediated BACE1 phosphorylation may occur in the lumen.	iodixanol	47-56	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	147-150
26317805-6	2015	Furthermore, the fraction of p25 prepared from iodixanol gradient centrifugation was unexpectedly protected by protease digestion, suggesting that p25/Cdk5-mediated BACE1 phosphorylation may occur in the lumen.	iodixanol	47-56	cyclin dependent kinase 5	Homo sapiens	151-155
26317805-6	2015	Furthermore, the fraction of p25 prepared from iodixanol gradient centrifugation was unexpectedly protected by protease digestion, suggesting that p25/Cdk5-mediated BACE1 phosphorylation may occur in the lumen.	iodixanol	47-56	beta-site APP cleaving enzyme 1	Mus musculus	165-170
26784323-10	2016	CONCLUSION: Avoiding reduced plasma t-PA activity might be an important consideration in choosing iodixanol over iohexol in patients at risk of thrombosis following angiography.	iodixanol	98-107	plasminogen activator, tissue type	Homo sapiens	36-40
25394939-7	2015	RESULTS: Iodixanol treatment of tubules significantly increased the concentration of Apn A (n = 3-5) in the supernatant.	iodixanol	9-18	alanyl aminopeptidase, membrane	Homo sapiens	85-88
26143944-7	2015	Docking studies of top hits with XIAP-BIR3 domain shows that Iodixanol (DB01249) and ZINC68678304 have higher binding affinities than well-known tetrapeptide inhibitor, AVPI.	iodixanol	61-70	X-linked inhibitor of apoptosis	Homo sapiens	33-37
26143944-7	2015	Docking studies of top hits with XIAP-BIR3 domain shows that Iodixanol (DB01249) and ZINC68678304 have higher binding affinities than well-known tetrapeptide inhibitor, AVPI.	iodixanol	72-79	X-linked inhibitor of apoptosis	Homo sapiens	33-37
24988006-7	2014	Elevated levels of tumor necrosis factor-alpha (7.1-fold), macrophage inflammatory protein (MIP)-1alpha (3.2-fold), and MIP-2 (7.7-fold) were identified 1 hour after the iodixanol injection.	iodixanol	170-179	tumor necrosis factor	Rattus norvegicus	19-46
24988006-7	2014	Elevated levels of tumor necrosis factor-alpha (7.1-fold), macrophage inflammatory protein (MIP)-1alpha (3.2-fold), and MIP-2 (7.7-fold) were identified 1 hour after the iodixanol injection.	iodixanol	170-179	C-C motif chemokine ligand 3	Rattus norvegicus	59-103
24988006-7	2014	Elevated levels of tumor necrosis factor-alpha (7.1-fold), macrophage inflammatory protein (MIP)-1alpha (3.2-fold), and MIP-2 (7.7-fold) were identified 1 hour after the iodixanol injection.	iodixanol	170-179	C-X-C motif chemokine ligand 2	Rattus norvegicus	120-125
24300339-13	2014	In conclusion, at angiographic concentrations, iodixanol induces fewer cytotoxic effects on cultured tubular cells than iohexol and iopamidol along with a lower induction of Nox4-dependent ROS generation.	iodixanol	47-56	NADPH oxidase 4	Homo sapiens	174-178
25147646-5	2014	METHODS: Platelets isolated with iodixanol gradient were activated by thrombin and collagen, lipopolysaccharide (LPS) or Ca(2+) ionophore.	iodixanol	33-42	coagulation factor II, thrombin	Homo sapiens	70-78
24449631-12	2014	CONCLUSION: To our knowledge, this is the first study indicating ICAM-1, VCAM-1 inducing effect of CAG in patients with SAP, USAP and differential effects of iodixanol and iopamidol on ICAM-1, VCAM-1 serum levels.	iodixanol	158-167	intercellular adhesion molecule 1	Homo sapiens	185-191
22985912-5	2013	The secretion of proinflammatory products was strongly stimulated by sequential incubation of EC with iodixanol and TNFalpha (p<0.00001 for all tested molecules, namely TNFalpha, IL-8, sVCAM-1, MCP-1, and IL-6).	iodixanol	102-111	C-X-C motif chemokine ligand 8	Homo sapiens	182-186
24239896-3	2014	We found that three distinct CM, including high-osmolar (diatrizoate), low-osmolar (iopamidol), and iso-osmolar (iodixanol), stimulated the expression of HO-1 protein and mRNA.	iodixanol	113-122	heme oxygenase 1	Homo sapiens	154-158
22985912-5	2013	The secretion of proinflammatory products was strongly stimulated by sequential incubation of EC with iodixanol and TNFalpha (p<0.00001 for all tested molecules, namely TNFalpha, IL-8, sVCAM-1, MCP-1, and IL-6).	iodixanol	102-111	C-C motif chemokine ligand 2	Homo sapiens	197-202
22985912-5	2013	The secretion of proinflammatory products was strongly stimulated by sequential incubation of EC with iodixanol and TNFalpha (p<0.00001 for all tested molecules, namely TNFalpha, IL-8, sVCAM-1, MCP-1, and IL-6).	iodixanol	102-111	interleukin 6	Homo sapiens	208-212
22975938-0	2012	Influence of radiographic contrast media (Iodixanol and Iomeprol) on the endothelin-1 release from human arterial and venous endothelial cells cultured on an extracellular matrix.	iodixanol	42-51	endothelin 1	Homo sapiens	73-85
21618678-6	2012	Fibrin formed with iodixanol was stiffer (42.7 +- 41.9, 18.7 +- 3.7, and 15.9 +- 9 dyne/cm(2) , P < 0.01) and displayed more fibrin fibers (1089 +- 175, 260 +- 108, and 456 +- 131 n/10(-5) /mum(2) , respectively, P < 0.01) than with ioxaglate or control.	iodixanol	19-28	trafficking protein particle complex subunit 1	Homo sapiens	193-199
22864374-20	2012	More detailed analysis of markers for AKI revealed that iodixanol significantly induced the expression of PAI-1 (7.7-fold at 2 hours) as well as KIM-1 (2.1-fold) and NGAL (3.2-fold) at 2 and 24 hours when compared with saline treatment.	iodixanol	56-65	serpin family E member 1	Rattus norvegicus	106-111
22864374-20	2012	More detailed analysis of markers for AKI revealed that iodixanol significantly induced the expression of PAI-1 (7.7-fold at 2 hours) as well as KIM-1 (2.1-fold) and NGAL (3.2-fold) at 2 and 24 hours when compared with saline treatment.	iodixanol	56-65	hepatitis A virus cellular receptor 1	Rattus norvegicus	145-150
22864374-20	2012	More detailed analysis of markers for AKI revealed that iodixanol significantly induced the expression of PAI-1 (7.7-fold at 2 hours) as well as KIM-1 (2.1-fold) and NGAL (3.2-fold) at 2 and 24 hours when compared with saline treatment.	iodixanol	56-65	lipocalin 2	Rattus norvegicus	166-170
22975938-4	2012	Exposition to Iodixanol supplemented culture medium was followed by endothelin-1 release from venous endothelial cells which was equivalent to the endothelin-1 release from venous control cultures.	iodixanol	14-23	endothelin 1	Homo sapiens	68-80
22975938-4	2012	Exposition to Iodixanol supplemented culture medium was followed by endothelin-1 release from venous endothelial cells which was equivalent to the endothelin-1 release from venous control cultures.	iodixanol	14-23	endothelin 1	Homo sapiens	147-159
21375605-8	2011	Iodixanol induced maturation of imDC from patients but not from controls, with expression of the co-stimulatory markers CD83, CD86 and CD40 and an increase in mean fluorescence intensity of CD80, CD86 and HLA-DR.	iodixanol	0-9	CD83 molecule	Homo sapiens	120-124
21375605-8	2011	Iodixanol induced maturation of imDC from patients but not from controls, with expression of the co-stimulatory markers CD83, CD86 and CD40 and an increase in mean fluorescence intensity of CD80, CD86 and HLA-DR.	iodixanol	0-9	CD86 molecule	Homo sapiens	126-130
21375605-8	2011	Iodixanol induced maturation of imDC from patients but not from controls, with expression of the co-stimulatory markers CD83, CD86 and CD40 and an increase in mean fluorescence intensity of CD80, CD86 and HLA-DR.	iodixanol	0-9	CD40 molecule	Homo sapiens	135-139
21375605-8	2011	Iodixanol induced maturation of imDC from patients but not from controls, with expression of the co-stimulatory markers CD83, CD86 and CD40 and an increase in mean fluorescence intensity of CD80, CD86 and HLA-DR.	iodixanol	0-9	CD80 molecule	Homo sapiens	190-194
21375605-8	2011	Iodixanol induced maturation of imDC from patients but not from controls, with expression of the co-stimulatory markers CD83, CD86 and CD40 and an increase in mean fluorescence intensity of CD80, CD86 and HLA-DR.	iodixanol	0-9	CD86 molecule	Homo sapiens	196-200
20680288-8	2011	CONCLUSION: The use of iodixanol appears to be safe in patients with monoclonal gammopathies and an eGFR>= 60 ml/min/1.73 mq.	iodixanol	23-32	epidermal growth factor receptor	Homo sapiens	100-104
20680288-8	2011	CONCLUSION: The use of iodixanol appears to be safe in patients with monoclonal gammopathies and an eGFR>= 60 ml/min/1.73 mq.	iodixanol	23-32	CD59 molecule (CD59 blood group)	Homo sapiens	116-121
19104440-11	2009	Twenty-four hours after Iodixanol treatment, significantly increased levels of Kim-1/Havcr1 and HO-1/HMOX1 transcript levels were observed compared with the saline and Iopromide treatment.	iodixanol	24-33	hepatitis A virus cellular receptor 1	Rattus norvegicus	79-84
20458252-14	2010	The angiotensin II dose response curves showed greater reactivity for amidotrizoate, iopromide and iodixanol, when compared with controls.	iodixanol	99-108	angiotensinogen	Rattus norvegicus	4-18
21876233-5	2011	The decrease of cell-cell contacts with an increase of denuded subendothelial matrix areas in the functionally confluent endothelial cell layer on ECM were more pronounced after a five minute exposure of endothelial cells to Iomeprol compared to Iodixanol.	iodixanol	246-255	multimerin 1	Homo sapiens	147-150
19546176-9	2010	The ex vivo study showed significantly (p<0.05) decreased platelet adhesion and P-selectin expression after administration of ioversol and iodixanol.	iodixanol	142-151	selectin P	Homo sapiens	83-93
19546176-11	2010	The in vitro study showed that ioversol, iodixanol and ioxaglate significantly (p<0.05) and dose-dependently (beginning at 3 mg ml(-1)) decreased platelet adhesion and P-selectin expression.	iodixanol	41-50	selectin P	Homo sapiens	171-181
19546176-13	2010	In conclusion, ioversol, iodixanol and ioxaglate inhibit platelet adhesion and P-selectin expression, as well as plasma coagulation.	iodixanol	25-34	selectin P	Homo sapiens	79-89
19923798-9	2010	RESULTS: Diatrizoate, iodixanol and iothalamate, but not iohexol, induced the expression of ATF2 mRNA and phosphorylation of ATF2 in 293T cells in a time-dependent manner.	iodixanol	22-31	activating transcription factor 2	Homo sapiens	92-96
19923798-9	2010	RESULTS: Diatrizoate, iodixanol and iothalamate, but not iohexol, induced the expression of ATF2 mRNA and phosphorylation of ATF2 in 293T cells in a time-dependent manner.	iodixanol	22-31	activating transcription factor 2	Homo sapiens	125-129
20719078-10	2010	The production of cytokine/chemokine including IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-8, MIP-1beta, MCP-1, and RANTES but not tissue factor from the OptiPrep group was significantly lower during 48-h culture after isolation.	iodixanol	151-159	interferon gamma	Homo sapiens	68-77
20719078-10	2010	The production of cytokine/chemokine including IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-8, MIP-1beta, MCP-1, and RANTES but not tissue factor from the OptiPrep group was significantly lower during 48-h culture after isolation.	iodixanol	151-159	C-C motif chemokine ligand 4	Homo sapiens	91-100
20719078-10	2010	The production of cytokine/chemokine including IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-8, MIP-1beta, MCP-1, and RANTES but not tissue factor from the OptiPrep group was significantly lower during 48-h culture after isolation.	iodixanol	151-159	C-C motif chemokine ligand 2	Homo sapiens	102-107
19366904-7	2009	Vasoconstriction induced by angiotensin II was enhanced by iodixanol.	iodixanol	59-68	angiotensinogen	Homo sapiens	28-42
19366904-10	2009	CONCLUSION: Iodixanol in doses typically used for coronary interventions constricts DVR, intensifies angiotensin II-induced constriction, and reduces bioavailability of NO.	iodixanol	12-21	angiotensinogen	Homo sapiens	101-115
19104440-11	2009	Twenty-four hours after Iodixanol treatment, significantly increased levels of Kim-1/Havcr1 and HO-1/HMOX1 transcript levels were observed compared with the saline and Iopromide treatment.	iodixanol	24-33	hepatitis A virus cellular receptor 1	Rattus norvegicus	85-91
19104440-11	2009	Twenty-four hours after Iodixanol treatment, significantly increased levels of Kim-1/Havcr1 and HO-1/HMOX1 transcript levels were observed compared with the saline and Iopromide treatment.	iodixanol	24-33	heme oxygenase 1	Rattus norvegicus	96-100
19104440-11	2009	Twenty-four hours after Iodixanol treatment, significantly increased levels of Kim-1/Havcr1 and HO-1/HMOX1 transcript levels were observed compared with the saline and Iopromide treatment.	iodixanol	24-33	heme oxygenase 1	Rattus norvegicus	101-106
16495485-9	2006	Iodixanol gradient centrifugation showed VAMP7 to be isodense with ER and endosomes.	iodixanol	0-9	vesicle associated membrane protein 7	Homo sapiens	41-46
19713613-5	2009	The endothelin-1 release after incubation with Iodixanol was similar to the release in the control cultures.	iodixanol	47-56	endothelin 1	Homo sapiens	4-16
17630980-6	2007	The presence of the FAD mutant PS1 was associated with a slight shift in the subcellular localization of both holoAPP and APP CTFs toward iodixanol density gradient fractions that were enriched in a marker for the TGN.	iodixanol	138-147	presenilin 1	Mus musculus	31-34
17059388-8	2007	Moreover, iodixanol density gradient analyses revealed that tankyrase knockdown altered the basal-state partitioning of GLUT4 and IRAP within endosomal compartments, apparently by shifting both proteins toward less buoyant compartments.	iodixanol	10-19	tankyrase	Homo sapiens	60-69
17059388-8	2007	Moreover, iodixanol density gradient analyses revealed that tankyrase knockdown altered the basal-state partitioning of GLUT4 and IRAP within endosomal compartments, apparently by shifting both proteins toward less buoyant compartments.	iodixanol	10-19	solute carrier family 2 member 4	Homo sapiens	120-125
17059388-8	2007	Moreover, iodixanol density gradient analyses revealed that tankyrase knockdown altered the basal-state partitioning of GLUT4 and IRAP within endosomal compartments, apparently by shifting both proteins toward less buoyant compartments.	iodixanol	10-19	leucyl and cystinyl aminopeptidase	Homo sapiens	130-134
19249543-12	2009	There were significantly lower tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-6, and MIP-1beta productions from the OptiPrep-based density gradient group.	iodixanol	155-163	interleukin 6	Homo sapiens	114-118
19249543-12	2009	There were significantly lower tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-6, and MIP-1beta productions from the OptiPrep-based density gradient group.	iodixanol	155-163	C-C motif chemokine ligand 4	Homo sapiens	124-133
18199441-9	2008	Our preliminary results support the predictive value of iohexol and/or iodixanol clearance in a clinical environment to screen and identify patients at risk of developing CIN.	iodixanol	71-80	pyridoxal phosphatase	Homo sapiens	171-174
12783865-7	2003	Purification of the volutin granules using iodixanol density gradients indicated a preferential localization of the pyrophosphatase activity in addition to high concentrations of phosphate, pyrophosphate, short- and long-chain polyphosphate, but lack of markers of the plasma membrane.	iodixanol	43-52	AWN88_RS23445	Agrobacterium tumefaciens	116-131
16254348-11	2005	We also demonstrate that different properties of sucrose and iodixanol membrane flotation gradients may explain some discrepancies regarding Gag-raft interactions.	iodixanol	61-70	Pr55(Gag)	Human immunodeficiency virus 1	141-144
16118553-5	2005	This study investigated the correlation between calculated D/CrCL and experimentally measured AUC for the contrast agent iodixanol.	iodixanol	121-130	CRCL	Homo sapiens	61-65
15886810-4	2005	When blood samples were pre-incubated in the presence of 2%, 5%, and 10% of CM without stirring, both ioxaglate and iodixanol had little effect on unstimulated samples, but dose-independently decreased 1 microM ADP-induced platelet P-selectin expression and fibrinogen binding, and thus platelet-leukocyte aggregate formation.	iodixanol	116-125	selectin P	Homo sapiens	232-242
15886810-4	2005	When blood samples were pre-incubated in the presence of 2%, 5%, and 10% of CM without stirring, both ioxaglate and iodixanol had little effect on unstimulated samples, but dose-independently decreased 1 microM ADP-induced platelet P-selectin expression and fibrinogen binding, and thus platelet-leukocyte aggregate formation.	iodixanol	116-125	fibrinogen beta chain	Homo sapiens	258-268
15886810-5	2005	Ioxaglate had little effect on leukocyte CD11b expression, whilst iodixanol slightly enhanced resting and N-formyl-methionyl-leucyl-phenylalanine (fMLP; 0.1 microM)-stimulated leukocyte CD11b expression.	iodixanol	66-75	formyl peptide receptor 1	Homo sapiens	147-151
15886810-5	2005	Ioxaglate had little effect on leukocyte CD11b expression, whilst iodixanol slightly enhanced resting and N-formyl-methionyl-leucyl-phenylalanine (fMLP; 0.1 microM)-stimulated leukocyte CD11b expression.	iodixanol	66-75	integrin subunit alpha M	Homo sapiens	186-191
10940743-13	2000	During dialysis the clearances of iohexol and iodixanol were, respectively, 69 +/- 16 and 58 +/- 11 ml/min/1.73 m(2) when calculated from a single-pool model (hemodialysis clearance of CM from plasma).	iodixanol	46-55	CD59 molecule (CD59 blood group)	Homo sapiens	103-108
11451949-5	2001	By means of velocity centrifugation in sucrose gradients, equilibrium density centrifugation in iodixanol gradients, and immunofluorescence confocal microscopy, we determined that LPL and leptin were localized in different membrane structures.	iodixanol	96-105	lipoprotein lipase	Rattus norvegicus	180-183
11451949-5	2001	By means of velocity centrifugation in sucrose gradients, equilibrium density centrifugation in iodixanol gradients, and immunofluorescence confocal microscopy, we determined that LPL and leptin were localized in different membrane structures.	iodixanol	96-105	leptin	Rattus norvegicus	188-194
10195004-5	1998	A total dose of 600 mgI kg-1 bw of iodixanol (320 mgI ml-1) or iopromide (300 mgI ml-1) was injected.	iodixanol	35-44	interleukin 17F	Homo sapiens	54-58
10066454-6	1999	Isosmolar (290 mOsm/kg H2O) Visipaque (iodixanol, non-ionic) at 10% (v/v) concentrations also increased AQP-1 expression, and 25% v/v of Visipaque rendered morphological alterations of HRPTE cells and a 3-fold increase in AQP-1 expression after 24h exposure.	iodixanol	39-48	aquaporin 1 (Colton blood group)	Homo sapiens	104-109
10066454-6	1999	Isosmolar (290 mOsm/kg H2O) Visipaque (iodixanol, non-ionic) at 10% (v/v) concentrations also increased AQP-1 expression, and 25% v/v of Visipaque rendered morphological alterations of HRPTE cells and a 3-fold increase in AQP-1 expression after 24h exposure.	iodixanol	39-48	aquaporin 1 (Colton blood group)	Homo sapiens	222-227
10783294-2	2000	In Iodixanol-based density gradients, PS1 derivatives show a biphasic distribution, cofractionating with membranes containing ER-resident proteins and an additional population of membranes with low buoyant density that do not contain markers of the Golgi complex, ERGIC, COP II vesicles, ER exit compartment, COP II receptor, Golgi SNARE, trans-Golgi network, caveolar membranes, or endocytic vesicles.	iodixanol	3-12	presenilin 1	Homo sapiens	38-41
9020187-10	1997	When the CT-related reductase activity was assayed in subcellular fractions of PNS-derived membranes isolated on a 9-30% Iodixanol gradient, the activity, as measured by CT-A1 peptide formation localized to those fractions containing PDI.	iodixanol	121-130	prolyl 4-hydroxylase subunit beta	Homo sapiens	234-237
9685817-8	1998	Glucose solutions of 300, 580 and 825 mosmol, corresponding to the osmolalities of respectively iodixanol, ioxaglate and iohexol, increased the beta-TG secretion in parallel with the osmolalities.	iodixanol	96-105	pro-platelet basic protein	Homo sapiens	144-151
9685821-3	1998	The dialyzer clearance of iodixanol dissolved in a mixture of leukocyte-filtered SAG-M blood and compatible citrate plasma was 134.2 +/- 3.6 ml/min for the polysulfone membrane and 113.0 +/- 3.6 ml/min for the cellulose triacetate membrane.	iodixanol	26-35	S-antigen visual arrestin	Homo sapiens	81-84
24005192-1	2013	PURPOSE: To investigate the effect of Iodixanol on kidney proximal tubular cell line human kidney 2 (HK-2).	iodixanol	38-47	hexokinase 2	Homo sapiens	101-105
8883523-0	1996	Iodixanol injection: a nonionic, isosmolar, hexa-iodinated contrast agent.	iodixanol	0-9	hexosaminidase subunit alpha	Homo sapiens	44-48
8883524-0	1996	Safety, tolerance, and pharmacokinetics of iodixanol injection, a nonionic, isosmolar, hexa-iodinated contrast agent.	iodixanol	43-52	hexosaminidase subunit alpha	Homo sapiens	87-91
8883529-2	1996	Iodixanol is a new isosmotic hexa-iodinated nonionic contrast agent being evaluated for intravascular use.	iodixanol	0-9	hexosaminidase subunit alpha	Homo sapiens	29-33
24005192-2	2013	METHODS: The HK-2 cells were treated with Iodixanol.	iodixanol	42-51	hexokinase 2	Homo sapiens	13-17
34373477-6	2021	The cysteine residues with free thiol groups after the RGD motif within the inserted RGD-4C peptide were responsible for formation of the interparticle disulfide bonds under atmospheric oxygen and aggregation of Ad5-delta-24-RGD4C-based rAds during 2 x CsCl gradient ultracentrifugation, which could be prevented using iodixanol gradient ultracentrifugation, most likely due to antioxidant properties of iodixanol.	iodixanol	404-413	Alzheimer disease, familial, type 5	Homo sapiens	212-215
34940619-6	2021	Two methods, iodixanol ultracentrifugation and column chromatography, which did not involve precipitation or high salt concentration, consistently showed an interaction of PCSK9 with a subfraction of LDL that appeared to be more buoyant and have a lower size than average LDL.	iodixanol	13-22	proprotein convertase subtilisin/kexin type 9	Homo sapiens	172-177
35098531-6	2022	Two randomised, double-blind, placebo-controlled, three-period cross-over studies (n=8) assessed the effect of oral and intravenous (IV) NAC in healthy kidneys in the presence/absence of iso-osmolar contrast (iodixanol).	iodixanol	209-218	synuclein alpha	Homo sapiens	137-140