PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15072549-4	2004	Using yeast microsomes expressing human P450c17 and 3betaHSDII we found that cinnamic acid methyl esters with a double bond in the thiazolidinedione core structure (M3, M5) were stronger inhibitors of P450c17 than methyl esters with the conventional core (M1, M4).	methyl cinnamate	77-104	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	40-47
29802834-2	2018	In this study, we investigated the effect of methyl cinnamate (MC), a flavoring agent widely used in food and commodity industry, on CCI-induced upregulation of spinal AMPARs and pain hypersensitive behaviors.	methyl cinnamate	45-61	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	168-174
29802834-2	2018	In this study, we investigated the effect of methyl cinnamate (MC), a flavoring agent widely used in food and commodity industry, on CCI-induced upregulation of spinal AMPARs and pain hypersensitive behaviors.	methyl cinnamate	63-65	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	168-174
29802834-6	2018	MC treatment reversed CCI-induced upregulation of GluR2, GluR3 and phosphorylation of GluR1.	methyl cinnamate	0-2	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	50-55
29802834-6	2018	MC treatment reversed CCI-induced upregulation of GluR2, GluR3 and phosphorylation of GluR1.	methyl cinnamate	0-2	glutamate ionotropic receptor AMPA type subunit 3	Rattus norvegicus	57-62
22273148-0	2012	Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathway in 3T3-L1 preadipocytes.	methyl cinnamate	0-16	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	74-80
22273148-4	2012	Methyl cinnamate markedly suppressed triglyceride accumulation associated with down-regulation of adipogenic transcription factor expression, including sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor gamma (PPARgamma), and CCAAT/enhancer-binding protein alpha (C/EBPalpha).	methyl cinnamate	0-16	sterol regulatory element binding transcription factor 1	Mus musculus	152-195
22273148-4	2012	Methyl cinnamate markedly suppressed triglyceride accumulation associated with down-regulation of adipogenic transcription factor expression, including sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor gamma (PPARgamma), and CCAAT/enhancer-binding protein alpha (C/EBPalpha).	methyl cinnamate	0-16	sterol regulatory element binding transcription factor 1	Mus musculus	197-204
22273148-4	2012	Methyl cinnamate markedly suppressed triglyceride accumulation associated with down-regulation of adipogenic transcription factor expression, including sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor gamma (PPARgamma), and CCAAT/enhancer-binding protein alpha (C/EBPalpha).	methyl cinnamate	0-16	peroxisome proliferator activated receptor gamma	Mus musculus	207-255
22273148-4	2012	Methyl cinnamate markedly suppressed triglyceride accumulation associated with down-regulation of adipogenic transcription factor expression, including sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor gamma (PPARgamma), and CCAAT/enhancer-binding protein alpha (C/EBPalpha).	methyl cinnamate	0-16	peroxisome proliferator activated receptor gamma	Mus musculus	257-266
22273148-4	2012	Methyl cinnamate markedly suppressed triglyceride accumulation associated with down-regulation of adipogenic transcription factor expression, including sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor gamma (PPARgamma), and CCAAT/enhancer-binding protein alpha (C/EBPalpha).	methyl cinnamate	0-16	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	273-309
22273148-4	2012	Methyl cinnamate markedly suppressed triglyceride accumulation associated with down-regulation of adipogenic transcription factor expression, including sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor gamma (PPARgamma), and CCAAT/enhancer-binding protein alpha (C/EBPalpha).	methyl cinnamate	0-16	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	311-321
22273148-5	2012	Additionally, methyl cinnamate-inhibited PPARgamma activity and adipocyte differentiation were partially reversed by the PPARgamma agonist troglitazone.	methyl cinnamate	14-30	peroxisome proliferator activated receptor gamma	Mus musculus	41-50
22273148-5	2012	Additionally, methyl cinnamate-inhibited PPARgamma activity and adipocyte differentiation were partially reversed by the PPARgamma agonist troglitazone.	methyl cinnamate	14-30	peroxisome proliferator activated receptor gamma	Mus musculus	121-130
22273148-6	2012	Furthermore, methyl cinnamate stimulated Ca(2+)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and phospho-AMP-activated protein kinase (AMPK) expression during adipogenesis.	methyl cinnamate	13-29	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	41-92
22273148-6	2012	Furthermore, methyl cinnamate stimulated Ca(2+)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and phospho-AMP-activated protein kinase (AMPK) expression during adipogenesis.	methyl cinnamate	13-29	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	94-100
22273148-7	2012	This study first revealed methyl cinnamate has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway in 3T3-L1 cells.	methyl cinnamate	26-42	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	116-122
17221961-2	2007	Irradiation of the host-guest complexes of trans-cinnamic acid methyl esters with the Pd nanocage resulted in selective formation of a syn head-head dimer in addition to the corresponding cis isomer.	methyl cinnamate	43-76	synemin	Homo sapiens	135-138
29802834-6	2018	MC treatment reversed CCI-induced upregulation of GluR2, GluR3 and phosphorylation of GluR1.	methyl cinnamate	0-2	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
29802834-7	2018	Further, MC dosage-dependently alleviated CCI-induced activation of mTOR and the downstream p70s6k.	methyl cinnamate	9-11	mechanistic target of rapamycin kinase	Rattus norvegicus	68-72
29802834-7	2018	Further, MC dosage-dependently alleviated CCI-induced activation of mTOR and the downstream p70s6k.	methyl cinnamate	9-11	ribosomal protein S6 kinase B1	Rattus norvegicus	92-98
28764029-0	2017	Interaction of cinnamic acid and methyl cinnamate with bovine serum albumin: A thermodynamic approach.	methyl cinnamate	33-49	albumin	Homo sapiens	62-75
28764029-2	2017	Here, we investigated the interaction of CA and MC with bovine serum albumin (BSA) at pH 3.5, 5.0, and 7.4 using fluorescence spectroscopy, differential scanning nanocalorimetry, and measurements of interfacial tension, size, and zeta potential.	methyl cinnamate	48-50	albumin	Homo sapiens	63-76
28456625-3	2017	Methyl cinnamate inhibits mushroom tyrosinase-catalyzed l-tyrosine oxidation while the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) was not inhibited.	methyl cinnamate	0-16	tyrosinase	Mus musculus	35-45
15072549-4	2004	Using yeast microsomes expressing human P450c17 and 3betaHSDII we found that cinnamic acid methyl esters with a double bond in the thiazolidinedione core structure (M3, M5) were stronger inhibitors of P450c17 than methyl esters with the conventional core (M1, M4).	methyl cinnamate	77-104	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	201-208
8756354-1	1996	The p-toluenesulfonamide derivate of the C-13 side-chain of taxol was prepared on a one third mole scale in a single step from methyl cinnamate.	methyl cinnamate	127-143	homeobox C13	Homo sapiens	41-45