PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31866541-0 2020 Electrospun poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/silk fibroin film is a promising scaffold for bone tissue engineering. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 12-57 fibroin light chain Bombyx mori 63-70 35054086-15 2022 By using poly (3-hydroxybutyrate-co-3-hydroxyhexanoate, PHBHHx)-mesoporous bioactive glass (PHMG) scaffold with MEG3 knockdown BMSCs, we found that downregulation of MEG3 in BMSCs could accelerate bone repairing in a critical-sized skull defects rat model. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 9-54 similar to GTL2, imprinted maternally expressed untranslated Rattus norvegicus 166-170 35054086-15 2022 By using poly (3-hydroxybutyrate-co-3-hydroxyhexanoate, PHBHHx)-mesoporous bioactive glass (PHMG) scaffold with MEG3 knockdown BMSCs, we found that downregulation of MEG3 in BMSCs could accelerate bone repairing in a critical-sized skull defects rat model. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 56-62 similar to GTL2, imprinted maternally expressed untranslated Rattus norvegicus 166-170 14558123-1 2003 We report an electrospray ionisation multistage mass spectrometry (ESI-MSn) method that utilises molecular mass information for determination of sequence distribution and chemical structure of mass-selected macromolecules of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) biopolyester, PHBH. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 225-270 moesin Homo sapiens 71-74 28895364-0 2017 [Development of tumor targeting PHBHHx nanoparticles by PhaP mediated immobilization of EGFR-targeting peptide]. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 32-38 epidermal growth factor receptor Homo sapiens 88-92 31198025-5 2019 PHBHHx NPs presented significantly improved cellular uptake in human prostate cancer cell line PC3, thereby enhancing the antiproliferation ability and kinase inhibitory activity of BEZ in vitro. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 0-6 chromobox 8 Homo sapiens 95-98 30893550-3 2019 We synthesized the poly(3-hydroxybutyrate- co-3-hydroxyhexanoate)-based cationic NPs (CNPs) and investigated the CNP-digestive enzyme interaction and its effect on the cellular uptake. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 19-65 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 86-89 28895364-3 2017 The tumor targeting PHBHHx nanoparticles were developed based on PhaP mediated ETP immobilization and the cellular uptake of the ETP-PhaP modified PHBHHx NPs and none modified PHBHHx NPs by cervical cancer cell lines SiHa (EGFR over expressed) and CaSKi (EGFR low expressed) were analyzed. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 20-26 epidermal growth factor receptor Homo sapiens 223-227 28895364-3 2017 The tumor targeting PHBHHx nanoparticles were developed based on PhaP mediated ETP immobilization and the cellular uptake of the ETP-PhaP modified PHBHHx NPs and none modified PHBHHx NPs by cervical cancer cell lines SiHa (EGFR over expressed) and CaSKi (EGFR low expressed) were analyzed. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 20-26 epidermal growth factor receptor Homo sapiens 255-259 28895364-5 2017 The ETP-PhaP modified PHBHHx NPs could target to EGFR over expressed cervical cancer cells SiHa more efficiently than to the EGFR low expressed CaSKi cells. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 22-28 epidermal growth factor receptor Homo sapiens 49-53 28895364-5 2017 The ETP-PhaP modified PHBHHx NPs could target to EGFR over expressed cervical cancer cells SiHa more efficiently than to the EGFR low expressed CaSKi cells. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 22-28 epidermal growth factor receptor Homo sapiens 125-129 24966038-6 2014 In accord with actin dynamics, the expressions of contractile smooth muscle markers, such as SM22 and SMA, decreased in VSMCs cultured on microgrooved substrates compared to those on flat ones, though PHBHHx can induce the synthetic-to-contractile phenotype shift. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 201-207 survival of motor neuron 1, telomeric Homo sapiens 102-105 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 RUNX family transcription factor 2 Homo sapiens 176-181 22846711-6 2012 The purified B7-2-PhaP protein was immobilized on the surface of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx)-based nanoparticles. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 65-110 CD86 molecule Homo sapiens 13-17 22846711-6 2012 The purified B7-2-PhaP protein was immobilized on the surface of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx)-based nanoparticles. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 112-118 CD86 molecule Homo sapiens 13-17 22846711-8 2012 Immobilized B7-2-PhaP on PHBHHx nanoparticles induced T cell activation and proliferation in vitro. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 25-31 CD86 molecule Homo sapiens 12-16 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 collagen type I alpha 1 chain Homo sapiens 183-189 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 bone morphogenetic protein 2 Homo sapiens 194-198 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 vinculin Homo sapiens 233-241 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 lipoprotein lipase Homo sapiens 294-297 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 actin alpha 2, smooth muscle Homo sapiens 307-312 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 myosin heavy chain 11 Homo sapiens 353-358 21890196-4 2011 Compared to MSCs cultured on the smooth substrates, MSCs incubated on microgrooved PHBHHx substrates showed increased expression of osteogenesis-related marker genes including cbfa1, col1a1 and bmp2, and decreased expression of vcl, vinculin encoding gene, adipogenesis-related genes including lpl, des and acta2, as well as myogenesis-related genes of myh11 and nse. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 83-89 enolase 2 Homo sapiens 363-366 15998539-1 2005 Random copolyester of 3-hydroxybutyrate and 3-hydroxyhexanoate, short as PHBHHx, was surface modified by ammonia plasma treatment and/or fibronectin coating, respectively. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 73-79 fibronectin 1 Homo sapiens 137-148 15998539-3 2005 Confocal microscopy observation showed that the specific co-localization of fibronectin with F-actin was impaired on PFn-PHBHHx, while it was almost lost on Fn-PHBHHx compared with pristine PHBHHx or plasma-treated PHBHHx (P-PHBHHx). poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 121-127 fibronectin 1 Homo sapiens 76-87 15998539-3 2005 Confocal microscopy observation showed that the specific co-localization of fibronectin with F-actin was impaired on PFn-PHBHHx, while it was almost lost on Fn-PHBHHx compared with pristine PHBHHx or plasma-treated PHBHHx (P-PHBHHx). poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 160-166 fibronectin 1 Homo sapiens 76-87 15998539-3 2005 Confocal microscopy observation showed that the specific co-localization of fibronectin with F-actin was impaired on PFn-PHBHHx, while it was almost lost on Fn-PHBHHx compared with pristine PHBHHx or plasma-treated PHBHHx (P-PHBHHx). poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 160-166 fibronectin 1 Homo sapiens 76-87 15998539-3 2005 Confocal microscopy observation showed that the specific co-localization of fibronectin with F-actin was impaired on PFn-PHBHHx, while it was almost lost on Fn-PHBHHx compared with pristine PHBHHx or plasma-treated PHBHHx (P-PHBHHx). poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 160-166 fibronectin 1 Homo sapiens 76-87 16134174-9 2005 Compared to unmodified PHBHHx, fibronectin adsorption, and MC3T3-E1 cell attachment and proliferation were significantly greater on surface-hydrolyzed PHBHHx, which may be due to the increased surface free energy and rougher surface. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 151-157 fibronectin 1 Mus musculus 31-42 15998539-2 2005 The improved results were demonstrated by better growth of human umbilical vein endothelial cells (HUVECs) and rabbit aorta smooth muscle cells (SMCs) on the surface of ammonia plasma-treated PHBHHx coated with fibronectin (PFn-PHBHHx), compared with the fibronectin-coated (Fn-PHBHHx) or uncoated PHBHHx, respectively, although XPS analysis and ELISA demonstrated higher fibronectin adsorption on Fn-PHBHHx than on PFn-PHBHHx. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 192-198 fibronectin 1 Homo sapiens 211-222 15998539-2 2005 The improved results were demonstrated by better growth of human umbilical vein endothelial cells (HUVECs) and rabbit aorta smooth muscle cells (SMCs) on the surface of ammonia plasma-treated PHBHHx coated with fibronectin (PFn-PHBHHx), compared with the fibronectin-coated (Fn-PHBHHx) or uncoated PHBHHx, respectively, although XPS analysis and ELISA demonstrated higher fibronectin adsorption on Fn-PHBHHx than on PFn-PHBHHx. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 192-198 fibronectin 1 Homo sapiens 255-266 15998539-2 2005 The improved results were demonstrated by better growth of human umbilical vein endothelial cells (HUVECs) and rabbit aorta smooth muscle cells (SMCs) on the surface of ammonia plasma-treated PHBHHx coated with fibronectin (PFn-PHBHHx), compared with the fibronectin-coated (Fn-PHBHHx) or uncoated PHBHHx, respectively, although XPS analysis and ELISA demonstrated higher fibronectin adsorption on Fn-PHBHHx than on PFn-PHBHHx. poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) 192-198 fibronectin 1 Homo sapiens 255-266