PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23499698-5	2013	Cyclopiazonic acid, a SERCA inhibitor, decreased the rate of relaxation and the rate of Ca(2+) transient decay; these effects were larger in control mice.	cyclopiazonic acid	0-18	ATPase, Ca++ transporting, ubiquitous	Mus musculus	22-27
23218930-4	2013	Cyclopiazonic acid induced SOCE was characterised in hippocampal cultures derived from forebrain specific protein tyrosine phosphatase 1B knockout (PTP1B KO) mice and wild type (WT) litter mates using Fura-2 Ca(2+) imaging.	cyclopiazonic acid	0-18	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	106-137
23280445-6	2013	Our findings indicate that SS is a reversible inhibitor of SERCA and that both SS and CELE bind SERCA at its cyclopiazonic acid binding site.	cyclopiazonic acid	109-127	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	96-101
23218930-4	2013	Cyclopiazonic acid induced SOCE was characterised in hippocampal cultures derived from forebrain specific protein tyrosine phosphatase 1B knockout (PTP1B KO) mice and wild type (WT) litter mates using Fura-2 Ca(2+) imaging.	cyclopiazonic acid	0-18	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	148-153
22529213-7	2012	CPA pretreatment enhanced IL-1beta- induced, but not TNF-alpha-induced, expression of chemokine (C-C motif) ligand 2, chemokine (C-X-C motif) ligand 1, inducible nitric oxide synthase, and Fas via augmented nuclear factor kappaB (NF-kappaB) activation.	cyclopiazonic acid	0-3	interleukin 1 beta	Rattus norvegicus	26-34
22529213-7	2012	CPA pretreatment enhanced IL-1beta- induced, but not TNF-alpha-induced, expression of chemokine (C-C motif) ligand 2, chemokine (C-X-C motif) ligand 1, inducible nitric oxide synthase, and Fas via augmented nuclear factor kappaB (NF-kappaB) activation.	cyclopiazonic acid	0-3	C-C motif chemokine ligand 2	Rattus norvegicus	86-183
22529213-8	2012	X-box binding protein 1 (XBP1) and inositol-requiring enzyme 1, but not CCAAT/enhancer binding protein homologous protein, knockdown prevented the CPA-induced exacerbation of NF-kappaB-dependent genes and decreased IL-1beta-induced NF-kappaB promoter activity.	cyclopiazonic acid	147-150	X-box binding protein 1	Rattus norvegicus	0-23
22529213-8	2012	X-box binding protein 1 (XBP1) and inositol-requiring enzyme 1, but not CCAAT/enhancer binding protein homologous protein, knockdown prevented the CPA-induced exacerbation of NF-kappaB-dependent genes and decreased IL-1beta-induced NF-kappaB promoter activity.	cyclopiazonic acid	147-150	X-box binding protein 1	Rattus norvegicus	25-29
22529213-8	2012	X-box binding protein 1 (XBP1) and inositol-requiring enzyme 1, but not CCAAT/enhancer binding protein homologous protein, knockdown prevented the CPA-induced exacerbation of NF-kappaB-dependent genes and decreased IL-1beta-induced NF-kappaB promoter activity.	cyclopiazonic acid	147-150	interleukin 1 beta	Rattus norvegicus	215-223
22687694-8	2012	Pharmacological manipulation with BAPTA-AM, cyclopiazonic acid, 2-aminoethoxydiphenyl borate and pyrazole-3 indicated that Ca2+ mobilization through TRPC3 was involved in thrombin-induced changes in the morphology of astrocytes.	cyclopiazonic acid	44-62	coagulation factor II, thrombin	Homo sapiens	171-179
21940663-6	2012	The time course of increase in CPA-induced contraction corresponded to that of TRPC1 expression.	cyclopiazonic acid	31-34	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	79-84
21968068-6	2012	Differential blocking actions of anti-TRPC antibodies and coimmunoprecipitation studies revealed that CPA induced heteromeric TRPC1/C5 channels in WT VSMCs and TRPC5 channels in TRPC1(-/-) VSMCs.	cyclopiazonic acid	102-105	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	126-131
21968068-6	2012	Differential blocking actions of anti-TRPC antibodies and coimmunoprecipitation studies revealed that CPA induced heteromeric TRPC1/C5 channels in WT VSMCs and TRPC5 channels in TRPC1(-/-) VSMCs.	cyclopiazonic acid	102-105	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	160-165
21968068-6	2012	Differential blocking actions of anti-TRPC antibodies and coimmunoprecipitation studies revealed that CPA induced heteromeric TRPC1/C5 channels in WT VSMCs and TRPC5 channels in TRPC1(-/-) VSMCs.	cyclopiazonic acid	102-105	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	178-183
21968068-7	2012	CPA-evoked TRPC1/C5 channel activity was prevented by the protein kinase C (PKC) inhibitor chelerythrine.	cyclopiazonic acid	0-3	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	11-16
21968068-9	2012	In contrast, CPA-evoked TRPC5 channel activity was potentiated by chelerythrine, and inhibited by PDBu, PIP(2), and PIP(3).	cyclopiazonic acid	13-16	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	24-29
21968068-9	2012	In contrast, CPA-evoked TRPC5 channel activity was potentiated by chelerythrine, and inhibited by PDBu, PIP(2), and PIP(3).	cyclopiazonic acid	13-16	prolactin induced protein	Mus musculus	104-107
21968068-9	2012	In contrast, CPA-evoked TRPC5 channel activity was potentiated by chelerythrine, and inhibited by PDBu, PIP(2), and PIP(3).	cyclopiazonic acid	13-16	prolactin induced protein	Mus musculus	116-119
22527639-2	2012	Depletion was produced by the application of 30 muM cyclopiazonic acid (CPA) in Ca2+-free, [Mg2+] = 8 mM external salines and produced an increase in resting free myoplasmic [Ca2+].	cyclopiazonic acid	52-70	latexin	Homo sapiens	48-51
22527639-5	2012	In the presence of CPA the resting myoplasmic [Ca2+] in Ca2+-free external saline was 0.08 +- 0.01 muM (Mean +- SEM), and in Ca2+-containing external saline 0.10 +- 0.02 muM when the intracellular solution contained [EGTA] = 5 mM (n = 18).	cyclopiazonic acid	19-22	latexin	Homo sapiens	99-102
22527639-5	2012	In the presence of CPA the resting myoplasmic [Ca2+] in Ca2+-free external saline was 0.08 +- 0.01 muM (Mean +- SEM), and in Ca2+-containing external saline 0.10 +- 0.02 muM when the intracellular solution contained [EGTA] = 5 mM (n = 18).	cyclopiazonic acid	19-22	latexin	Homo sapiens	170-173
22134903-5	2012	P2X7R activation for 2 h did not cause cell death but resulted in a sustained reduction in ER Ca2+ pool size, as evidenced by a diminished cyclopiazonic acid-induced Ca(2+) discharge (fura 2 assay) and a lower fluorescent signal in cells loaded with Mag-fura 2 (ER-specific Ca(2+)-fluorescent dye).	cyclopiazonic acid	139-157	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	0-5
21784843-6	2011	DN HNF1alpha-induced sensitivity to cyclopiazonic acid can be partially rescued with the chemical chaperone tauroursodeoxycholate.	cyclopiazonic acid	36-54	HNF1 homeobox A	Mus musculus	3-12
21881003-13	2011	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid inhibited pacemaker activity and Ca(2+) waves suggesting that a functional SERCA pump is necessary for pacemaker activity.	cyclopiazonic acid	69-87	ATPase, Ca++ transporting, ubiquitous	Mus musculus	4-45
21881003-13	2011	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid inhibited pacemaker activity and Ca(2+) waves suggesting that a functional SERCA pump is necessary for pacemaker activity.	cyclopiazonic acid	69-87	ATPase, Ca++ transporting, ubiquitous	Mus musculus	47-52
21881003-13	2011	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid inhibited pacemaker activity and Ca(2+) waves suggesting that a functional SERCA pump is necessary for pacemaker activity.	cyclopiazonic acid	69-87	ATPase, Ca++ transporting, ubiquitous	Mus musculus	163-168
21719297-1	2011	The indole alkaloid cyclopiazonic acid (CPA) is one of the few known nanomolar inhibitors of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) besides the anticancer drug thapsigargin and the antiplasmoidal terpenoid artemisinin.	cyclopiazonic acid	20-38	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	93-133
21565997-6	2011	Both STIM1 and ORAI1-ORAI3 mRNA knockdowns significantly attenuated oxytocin- and cyclopiazonic acid-stimulated SRCE.	cyclopiazonic acid	82-100	stromal interaction molecule 1	Homo sapiens	5-10
21565997-6	2011	Both STIM1 and ORAI1-ORAI3 mRNA knockdowns significantly attenuated oxytocin- and cyclopiazonic acid-stimulated SRCE.	cyclopiazonic acid	82-100	ORAI calcium release-activated calcium modulator 1	Homo sapiens	15-20
21565997-6	2011	Both STIM1 and ORAI1-ORAI3 mRNA knockdowns significantly attenuated oxytocin- and cyclopiazonic acid-stimulated SRCE.	cyclopiazonic acid	82-100	ORAI calcium release-activated calcium modulator 3	Homo sapiens	21-26
21719297-1	2011	The indole alkaloid cyclopiazonic acid (CPA) is one of the few known nanomolar inhibitors of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) besides the anticancer drug thapsigargin and the antiplasmoidal terpenoid artemisinin.	cyclopiazonic acid	40-43	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	93-133
20739625-5	2010	The nifedipine-insensitive transient rise in [Ca(2+)](i) and the increase in Mn(2+) quench of fura-2 fluorescence caused by CPA were both reduced in cells treated with Orai1 siRNA.	cyclopiazonic acid	124-127	ORAI calcium release-activated calcium modulator 1	Mus musculus	168-173
21599655-8	2011	Our data fully confirm that PfATP6 is a SERCA, but with a distinct pharmacological profile: compared with SERCA1a, it has a lower affinity for thapsigargin and much higher affinity for cyclopiazonic acid.	cyclopiazonic acid	185-203	sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus	106-113
20739625-6	2010	These responses to CPA were further reduced in cells treated with Orai1 and STIM1 small interfering (si)RNA.	cyclopiazonic acid	19-22	ORAI calcium release-activated calcium modulator 1	Mus musculus	66-71
20739625-6	2010	These responses to CPA were further reduced in cells treated with Orai1 and STIM1 small interfering (si)RNA.	cyclopiazonic acid	19-22	stromal interaction molecule 1	Mus musculus	76-81
20739625-7	2010	Moreover, overexpression of STIM1 enhanced the rise in [Ca(2+)](i) and the increase in Mn(2+) quench of fura-2 fluorescence caused by CPA, and these responses were reduced in cells treated with Orai1 siRNA.	cyclopiazonic acid	134-137	stromal interaction molecule 1	Mus musculus	28-33
20739625-7	2010	Moreover, overexpression of STIM1 enhanced the rise in [Ca(2+)](i) and the increase in Mn(2+) quench of fura-2 fluorescence caused by CPA, and these responses were reduced in cells treated with Orai1 siRNA.	cyclopiazonic acid	134-137	ORAI calcium release-activated calcium modulator 1	Mus musculus	194-199
20490897-5	2010	Hearts were challenged with beta-agonist isoproterenol and the sarcoplasmic reticular Ca(2+)-ATPase (SERCA2a) inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	120-138	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	101-108
19475562-5	2009	They were suppressed by the SOC entry channel blocker La3+, the phospholipase C (PLC) inhibitor U73122, the inositol trisphosphate receptor (IP3R) blocker 2-amino-ethoxydiphenyl borate, or the sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA) inhibitors thapsigargin and cyclopiazonic acid, but not by ryanodine.	cyclopiazonic acid	274-292	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	141-145
20222029-8	2010	In addition, expression of the maternal genes C-mos, BMP15, GDF9, and Cyclin B1 was significantly increased in CPA-treated MII oocytes compared with control groups.	cyclopiazonic acid	111-114	MOS proto-oncogene, serine/threonine kinase	Sus scrofa	46-51
20222029-8	2010	In addition, expression of the maternal genes C-mos, BMP15, GDF9, and Cyclin B1 was significantly increased in CPA-treated MII oocytes compared with control groups.	cyclopiazonic acid	111-114	bone morphogenetic protein 15	Sus scrofa	53-58
20222029-8	2010	In addition, expression of the maternal genes C-mos, BMP15, GDF9, and Cyclin B1 was significantly increased in CPA-treated MII oocytes compared with control groups.	cyclopiazonic acid	111-114	growth differentiation factor 9	Sus scrofa	60-64
20222029-8	2010	In addition, expression of the maternal genes C-mos, BMP15, GDF9, and Cyclin B1 was significantly increased in CPA-treated MII oocytes compared with control groups.	cyclopiazonic acid	111-114	cyclin B1	Sus scrofa	70-79
20222029-9	2010	These data were supported by the results of poly(A)-test PCR, which revealed that the cyclin B1 short isoform (CB-S), GDF9, and C-mos underwent more intensive polyadenylation modification in CPA-treated oocytes than control oocytes, suggesting that polyadenylation may influence Ca(2+)-modulated changes in gene expression.	cyclopiazonic acid	191-194	cyclin B1	Sus scrofa	86-95
20222029-9	2010	These data were supported by the results of poly(A)-test PCR, which revealed that the cyclin B1 short isoform (CB-S), GDF9, and C-mos underwent more intensive polyadenylation modification in CPA-treated oocytes than control oocytes, suggesting that polyadenylation may influence Ca(2+)-modulated changes in gene expression.	cyclopiazonic acid	191-194	growth differentiation factor 9	Sus scrofa	118-122
20222029-9	2010	These data were supported by the results of poly(A)-test PCR, which revealed that the cyclin B1 short isoform (CB-S), GDF9, and C-mos underwent more intensive polyadenylation modification in CPA-treated oocytes than control oocytes, suggesting that polyadenylation may influence Ca(2+)-modulated changes in gene expression.	cyclopiazonic acid	191-194	MOS proto-oncogene, serine/threonine kinase	Sus scrofa	128-133
20177054-7	2010	Application of the vasoconstrictor endothelin-1 induced global Ca(2+) waves in pulmonary arterial smooth muscle cells, which were markedly attenuated upon depletion of SR Ca(2+) stores by preincubation of cells with the SERCA inhibitor thapsigargin but remained unaffected after preincubation of cells with a second SERCA antagonist, cyclopiazonic acid.	cyclopiazonic acid	334-352	endothelin 1	Homo sapiens	35-47
19875453-8	2009	Ca(2+) measurements indicated that resting Ca(2+) and the rate of Ca(2+) increase induced by cyclopiazonic acid were higher in the TRPC1-YFP-positive zone than in the TRPC1-YFP-negative zone and control cells.	cyclopiazonic acid	93-111	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	131-136
19794517-6	2009	SERCA2 activity was measured by using 20 micromol/L cyclopiazonic acid (CPA) in a left ventricular papillary muscle preparation during isometric contraction in basal conditions and during post-rest contraction.	cyclopiazonic acid	52-70	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	0-6
19794517-6	2009	SERCA2 activity was measured by using 20 micromol/L cyclopiazonic acid (CPA) in a left ventricular papillary muscle preparation during isometric contraction in basal conditions and during post-rest contraction.	cyclopiazonic acid	72-75	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	0-6
19114088-4	2009	However, in cells expressing a dominant negative presenilin-1 mutant (PS1-D257A), gamma-secretase activity was inhibited and treatment with CPA evoked sustained Ca(2+) influx.	cyclopiazonic acid	140-143	presenilin 1	Rattus norvegicus	49-61
19386284-5	2009	In fura-2-loaded TRPC1 knockdown cells, despite the decreased TRPC1 levels, cyclopiazonic acid-induced Ca2+ entry and store-operated Ca2+ entry following Ca2+ addition were elevated by 77% and 135%, respectively.	cyclopiazonic acid	76-94	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	17-22
19386284-5	2009	In fura-2-loaded TRPC1 knockdown cells, despite the decreased TRPC1 levels, cyclopiazonic acid-induced Ca2+ entry and store-operated Ca2+ entry following Ca2+ addition were elevated by 77% and 135%, respectively.	cyclopiazonic acid	76-94	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	62-67
19332490-6	2009	The nifedipine-insensitive sustained rise in [Ca(2+)](i) and the increase in Mn(2+) quench of fura-2 fluorescence caused by CPA were both inhibited in cells pretreated with antibody raised against an extracellular epitope of TRPC1.	cyclopiazonic acid	124-127	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	225-230
19332490-7	2009	Moreover, STIM1 siRNA reduced the rise in [Ca(2+)](i) and Mn(2+) quench of fura-2 fluorescence caused by CPA, whereas overexpression of STIM1 resulted in a marked increase in these responses.	cyclopiazonic acid	105-108	stromal interaction molecule 1	Mus musculus	10-15
19458227-7	2009	Release suppression by mGluR1 blockade was prevented by 2-APB or CPA, indicating facilitation of DA release by endogenous glutamate acting via mGluR1s and IP(3)R-gated Ca(2+) stores.	cyclopiazonic acid	65-68	glutamate metabotropic receptor 1	Homo sapiens	23-29
19458227-7	2009	Release suppression by mGluR1 blockade was prevented by 2-APB or CPA, indicating facilitation of DA release by endogenous glutamate acting via mGluR1s and IP(3)R-gated Ca(2+) stores.	cyclopiazonic acid	65-68	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	155-161
19289472-1	2009	We have determined the structure of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in an E2.P(i)-like form stabilized as a complex with MgF(4)(2-), an ATP analog, adenosine 5"-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CPA).	cyclopiazonic acid	233-251	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	40-82
19289472-1	2009	We have determined the structure of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in an E2.P(i)-like form stabilized as a complex with MgF(4)(2-), an ATP analog, adenosine 5"-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CPA).	cyclopiazonic acid	233-251	signal transducer and activator of transcription 5A	Homo sapiens	144-147
19289472-1	2009	We have determined the structure of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in an E2.P(i)-like form stabilized as a complex with MgF(4)(2-), an ATP analog, adenosine 5"-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CPA).	cyclopiazonic acid	253-256	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	40-82
19289472-1	2009	We have determined the structure of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) in an E2.P(i)-like form stabilized as a complex with MgF(4)(2-), an ATP analog, adenosine 5"-(beta,gamma-methylene)triphosphate (AMPPCP), and cyclopiazonic acid (CPA).	cyclopiazonic acid	253-256	signal transducer and activator of transcription 5A	Homo sapiens	144-147
19244356-3	2009	We used indo-1-based microfluorimetry in the presence of cyclopiazonic acid to study the rate of PMCA-mediated recovery of Ca(2+) elevated by a brief train of action potentials.	cyclopiazonic acid	57-75	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	97-101
19114088-4	2009	However, in cells expressing a dominant negative presenilin-1 mutant (PS1-D257A), gamma-secretase activity was inhibited and treatment with CPA evoked sustained Ca(2+) influx.	cyclopiazonic acid	140-143	presenilin 1	Rattus norvegicus	70-73
19047197-3	2009	DiC8-PIP(2)-evoked channel currents were inhibited by anti-TRPC1 antibodies and these characteristics are identical to SOCs evoked by cyclopiazonic acid (CPA) and BAPTA-AM.	cyclopiazonic acid	134-152	prolactin-inducible protein homolog	Oryctolagus cuniculus	5-8
19047197-3	2009	DiC8-PIP(2)-evoked channel currents were inhibited by anti-TRPC1 antibodies and these characteristics are identical to SOCs evoked by cyclopiazonic acid (CPA) and BAPTA-AM.	cyclopiazonic acid	134-152	short transient receptor potential channel 1	Oryctolagus cuniculus	59-64
19047197-3	2009	DiC8-PIP(2)-evoked channel currents were inhibited by anti-TRPC1 antibodies and these characteristics are identical to SOCs evoked by cyclopiazonic acid (CPA) and BAPTA-AM.	cyclopiazonic acid	154-157	prolactin-inducible protein homolog	Oryctolagus cuniculus	5-8
19047197-3	2009	DiC8-PIP(2)-evoked channel currents were inhibited by anti-TRPC1 antibodies and these characteristics are identical to SOCs evoked by cyclopiazonic acid (CPA) and BAPTA-AM.	cyclopiazonic acid	154-157	short transient receptor potential channel 1	Oryctolagus cuniculus	59-64
19047197-4	2009	SOCs stimulated by CPA, BAPTA-AM and the phorbol ester phorbol 12,13-dibutyrate (PDBu) were reduced by anti-PIP(2) antibodies and by depletion of tissue PIP(2) levels by pre-treatment of preparations with wortmannin and LY294002.	cyclopiazonic acid	19-22	prolactin-inducible protein homolog	Oryctolagus cuniculus	108-111
19047197-8	2009	Co-immunoprecipitation experiments provide evidence that PKC-dependent phosphorylation of TRPC1 occurs constitutively and was increased by CPA and PDBu but decreased by chelerythrine.	cyclopiazonic acid	139-142	short transient receptor potential channel 1	Oryctolagus cuniculus	90-95
19047197-9	2009	These novel results show that PIP(2) can activate TRPC1 SOCs in native vascular myocytes and plays an important role in SOC activation by CPA, BAPTA-AM and PDBu.	cyclopiazonic acid	138-141	prolactin-inducible protein homolog	Oryctolagus cuniculus	30-33
18577871-5	2009	A number of CaSR agonists, such as spermine, Gd(3+), La(3+) and neomycin, elicited a heterogeneous intracellular Ca(2+) signal, which was abolished by disruption of inositol 1,4,5-trisphosphate (InsP(3)) signaling and by depletion of intracellular stores with cyclopiazonic acid.	cyclopiazonic acid	260-278	calcium sensing receptor	Homo sapiens	12-16
19056336-6	2009	LCA1 showed typical pharmacological sensitivities to cyclopiazonic acid, vanadate, and eosin, consistent with it being a P(IIA)-type Ca(2+)-ATPase.	cyclopiazonic acid	53-71	calcium-transporting ATPase, endoplasmic reticulum-type	Solanum lycopersicum	0-4
18836030-6	2008	Interestingly, CPA pretreatment significantly attenuated thrombin-induced Ca(2+) release in PASMC; this attenuation was not apparent in PAEC, indicating that a PAEC-specific mechanism was targeted by thrombin.	cyclopiazonic acid	15-18	coagulation factor II, thrombin	Homo sapiens	57-65
18836030-8	2008	Notably, thrombin-induced receptor-mediated calcium influx was still observed in PASMC after CPA pretreatment in the presence of extracellular Ca(2+).	cyclopiazonic acid	93-96	coagulation factor II, thrombin	Homo sapiens	9-17
18836030-6	2008	Interestingly, CPA pretreatment significantly attenuated thrombin-induced Ca(2+) release in PASMC; this attenuation was not apparent in PAEC, indicating that a PAEC-specific mechanism was targeted by thrombin.	cyclopiazonic acid	15-18	coagulation factor II, thrombin	Homo sapiens	200-208
18836030-10	2008	The data show that thrombin induces increases in intracellular calcium in PASMC and PAEC with a distinct CPA-, caffeine-, and ryanodine-insensitive release existing only in PAEC.	cyclopiazonic acid	105-108	coagulation factor II, thrombin	Homo sapiens	19-27
18669883-5	2008	CPA-evoked relaxations were attenuated by exogenous catalase and potentiated by the catalase inhibitor 3-aminotriazole, and were abolished by the connexin-mimetic peptide (43)Gap26, which interrupts intercellular communication via gap junctions constructed from connexin 43.	cyclopiazonic acid	0-3	gap junction alpha-1 protein	Oryctolagus cuniculus	262-273
18478545-7	2008	Pharmacological manipulation with BAPTA-AM, cyclopiazonic acid, and 2-aminoethoxydiphenyl borate indicated that Ca(2+) mobilization was involved in thrombin-induced morphological changes.	cyclopiazonic acid	44-62	coagulation factor II, thrombin	Homo sapiens	148-156
18239188-9	2008	Here we show that knockdown of ORAI1 by siRNA resulted in reduced thapsigargin- or cyclopiazonic acid (CPA)-induced Ca(2+) influx, without affecting Ca(2+) release from stores or basal levels.	cyclopiazonic acid	83-101	ORAI calcium release-activated calcium modulator 1	Homo sapiens	31-36
18716665-6	2008	JunB knockdown beta-cells and junB(-/-) fibroblasts were also more sensitive to the chemical ER stressor cyclopiazonic acid (CPA).	cyclopiazonic acid	105-123	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-4
18716665-6	2008	JunB knockdown beta-cells and junB(-/-) fibroblasts were also more sensitive to the chemical ER stressor cyclopiazonic acid (CPA).	cyclopiazonic acid	105-123	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-34
18716665-6	2008	JunB knockdown beta-cells and junB(-/-) fibroblasts were also more sensitive to the chemical ER stressor cyclopiazonic acid (CPA).	cyclopiazonic acid	125-128	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-4
18716665-6	2008	JunB knockdown beta-cells and junB(-/-) fibroblasts were also more sensitive to the chemical ER stressor cyclopiazonic acid (CPA).	cyclopiazonic acid	125-128	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-34
18239188-9	2008	Here we show that knockdown of ORAI1 by siRNA resulted in reduced thapsigargin- or cyclopiazonic acid (CPA)-induced Ca(2+) influx, without affecting Ca(2+) release from stores or basal levels.	cyclopiazonic acid	103-106	ORAI calcium release-activated calcium modulator 1	Homo sapiens	31-36
18239188-10	2008	CPA-induced inward currents were also reduced in the ORAI1 knockdown cells.	cyclopiazonic acid	0-3	ORAI calcium release-activated calcium modulator 1	Homo sapiens	53-58
18313206-5	2008	Erk phosphorylation was inhibited by the calcium inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	79-82	Eph receptor B1	Rattus norvegicus	0-3
18787888-8	2008	The ability to proliferate, the resting [Ca2+]cyt, and cyclopiazonic acid-induced capacitative Ca2+ entry in human PASMCs were enhanced significantly by chronic hypoxia compared with the control, and these effects were inhibited in a dose-dependent manner by capsazepine, a TRPV1 channel inhibitor.	cyclopiazonic acid	55-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	274-279
18313206-8	2008	Ghrelin phosphorylated TSH-induced p66Shc, which was inhibited by CPA.	cyclopiazonic acid	66-69	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
18313206-5	2008	Erk phosphorylation was inhibited by the calcium inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	59-77	Eph receptor B1	Rattus norvegicus	0-3
18313206-8	2008	Ghrelin phosphorylated TSH-induced p66Shc, which was inhibited by CPA.	cyclopiazonic acid	66-69	SHC adaptor protein 1	Rattus norvegicus	35-41
17172280-3	2007	Challenge with cyclopiazonic acid (10 microM), a sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase inhibitor, during the plateau of endothelin-1 constriction enhanced the constriction by approximately 30%.	cyclopiazonic acid	15-33	endothelin 1	Rattus norvegicus	131-143
18045856-6	2008	Caffeine decreased and cyclopiazonic acid (CPA) increased the basal tone of antrum smooth muscle strips from PLB-KO mice, but the effects were less pronounced compared with control strips.	cyclopiazonic acid	23-41	phospholamban	Mus musculus	109-112
18045856-6	2008	Caffeine decreased and cyclopiazonic acid (CPA) increased the basal tone of antrum smooth muscle strips from PLB-KO mice, but the effects were less pronounced compared with control strips.	cyclopiazonic acid	43-46	phospholamban	Mus musculus	109-112
18059326-11	2008	Furthermore, apoE(-/-) SMCs released less intracellular calcium than WT upon sarco-endoplasmic reticulum calcium ATPase (SERCA) inhibition by cyclopiazonic acid.	cyclopiazonic acid	142-160	apolipoprotein E	Mus musculus	13-17
17899169-6	2008	The differences disappeared after NOS inhibition or EC removal or upon increasing [Ca2+]i in apoE-/- strips with 10(-6) M cyclopiazonic acid or 10(-7) M Ca2+-ionophore A23187.	cyclopiazonic acid	122-140	apolipoprotein E	Mus musculus	93-97
18784973-3	2008	Depletion of Ca(2+) stores by cyclopiazonic acid (CPA) induced a Ca(2+) influx, which could be inhibited by SOCE channel blockers 2-aminoethoxy-diphenylborate (2-APB) and 3,5-bistrifluoromethyl pyrazole derivative (BTP2), but not by the voltage-operated Ca(2+) channel blocker diltiazem and by the Na+ channel blocker tetrodotoxin.	cyclopiazonic acid	30-48	arginyl aminopeptidase	Rattus norvegicus	162-165
18784973-3	2008	Depletion of Ca(2+) stores by cyclopiazonic acid (CPA) induced a Ca(2+) influx, which could be inhibited by SOCE channel blockers 2-aminoethoxy-diphenylborate (2-APB) and 3,5-bistrifluoromethyl pyrazole derivative (BTP2), but not by the voltage-operated Ca(2+) channel blocker diltiazem and by the Na+ channel blocker tetrodotoxin.	cyclopiazonic acid	50-53	arginyl aminopeptidase	Rattus norvegicus	162-165
17333111-9	2007	Levels of Ins1 and Ins2 mRNAs were severely decreased in response to CPA treatment as a result of degradation, and there was a concomitant increase in the level of IRE1 activation.	cyclopiazonic acid	69-72	insulin 1	Rattus norvegicus	10-14
17333111-9	2007	Levels of Ins1 and Ins2 mRNAs were severely decreased in response to CPA treatment as a result of degradation, and there was a concomitant increase in the level of IRE1 activation.	cyclopiazonic acid	69-72	insulin 2	Rattus norvegicus	19-23
17389383-3	2007	Here we describe the crystal structures of Ca(2+)-ATPase in the absence of Ca(2+) stabilized with cyclopiazonic acid alone and in combination with other inhibitors.	cyclopiazonic acid	98-116	dynein axonemal heavy chain 8	Homo sapiens	50-56
18052080-8	2007	2,5-Di-tert-butyl-1,4-dihydroxybenzene or cyclopiazonic acid, inhibitors which also bind in or near the transmembrane region, also produce similar overall effects on Ca2+-free ATPase.	cyclopiazonic acid	42-60	dynein axonemal heavy chain 8	Homo sapiens	176-182
17046058-6	2007	Cyclopiazonic acid (CPA; 5 microM), an inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), significantly decreased the peak amplitude, and slowed the decay, of the KCl-evoked Ca2+ transients in TGNs.	cyclopiazonic acid	0-18	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	56-95
17046058-6	2007	Cyclopiazonic acid (CPA; 5 microM), an inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), significantly decreased the peak amplitude, and slowed the decay, of the KCl-evoked Ca2+ transients in TGNs.	cyclopiazonic acid	0-18	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	97-102
17046058-6	2007	Cyclopiazonic acid (CPA; 5 microM), an inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), significantly decreased the peak amplitude, and slowed the decay, of the KCl-evoked Ca2+ transients in TGNs.	cyclopiazonic acid	20-23	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	56-95
17046058-6	2007	Cyclopiazonic acid (CPA; 5 microM), an inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), significantly decreased the peak amplitude, and slowed the decay, of the KCl-evoked Ca2+ transients in TGNs.	cyclopiazonic acid	20-23	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	97-102
17395747-3	2007	We presently studied the molecular regulation of Chop expression in insulin-producing cells (INS-1E) in response to three pro-apoptotic and endoplasmic reticulum stress-inducing agents, namely the cytokines interleukin-1beta + interferon-gamma, the free fatty acid palmitate, and the sarcoendoplasmic reticulum pump Ca(2+) ATPase blocker cyclopiazonic acid (CPA).	cyclopiazonic acid	338-356	DNA-damage inducible transcript 3	Rattus norvegicus	49-53
17395747-3	2007	We presently studied the molecular regulation of Chop expression in insulin-producing cells (INS-1E) in response to three pro-apoptotic and endoplasmic reticulum stress-inducing agents, namely the cytokines interleukin-1beta + interferon-gamma, the free fatty acid palmitate, and the sarcoendoplasmic reticulum pump Ca(2+) ATPase blocker cyclopiazonic acid (CPA).	cyclopiazonic acid	358-361	DNA-damage inducible transcript 3	Rattus norvegicus	49-53
17395747-6	2007	Cytokines, palmitate, and CPA induced eIF2alpha phosphorylation in INS-1E cells leading to activation of the transcription factor ATF4.	cyclopiazonic acid	26-29	activating transcription factor 4	Rattus norvegicus	130-134
17395747-4	2007	Detailed mutagenesis studies of the Chop promoter showed differential regulation of Chop transcription by CPA, cytokines, and palmitate.	cyclopiazonic acid	106-109	DNA-damage inducible transcript 3	Rattus norvegicus	36-40
17395747-4	2007	Detailed mutagenesis studies of the Chop promoter showed differential regulation of Chop transcription by CPA, cytokines, and palmitate.	cyclopiazonic acid	106-109	DNA-damage inducible transcript 3	Rattus norvegicus	84-88
17395747-6	2007	Cytokines, palmitate, and CPA induced eIF2alpha phosphorylation in INS-1E cells leading to activation of the transcription factor ATF4.	cyclopiazonic acid	26-29	eukaryotic translation initiation factor 2A	Rattus norvegicus	38-47
17136772-7	2007	Application of ATP evoked CPA-sensitive Ca(2+) transients in OECs, which were inhibited by the P2Y(1)-specific antagonist MRS2179.	cyclopiazonic acid	26-29	purinergic receptor P2Y, G-protein coupled 1	Mus musculus	95-101
16604358-10	2006	Pretreatment with IFN-gamma decreased the basal level of spliced Xbp1 mRNA, the basal and CPA-induced activity of the UPRE reporter, and the mRNA expression of several endoplasmic reticulum chaperones (Bip, Grp94 and Orp 150) and Sec61a.	cyclopiazonic acid	90-93	interferon gamma	Rattus norvegicus	18-27
17330864-8	2007	We found that bath application of SERCA pump inhibitors (cyclopiazonic acid and thapsigargin), as well as an agonist of ryanodine receptors (ryanodine 2 microM) increases the probability of glutamate release at CA3-CA1 synapses, decreases the coefficient of variation and the paired-pulse ratio, indicating that presynaptic activation of calcium-induced calcium release can modulate glutamatergic transmission.	cyclopiazonic acid	57-75	carbonic anhydrase 3	Rattus norvegicus	211-218
16905161-3	2007	The priming of LTP by DHPG was prevented by co-administration of cyclopiazonic acid, which depletes ER Ca2+ stores.	cyclopiazonic acid	65-83	carbonic anhydrase 2	Rattus norvegicus	103-106
16870295-5	2006	The PyK2 phosphorylation level declined after treatment of 2 microg/ml CsA, 5 microM CPA and 25 microM U73122, but not changed apparently after 50 microM ryanodine treatment.	cyclopiazonic acid	85-88	protein tyrosine kinase 2 beta	Homo sapiens	4-8
17142482-6	2007	To investigate the effect of AtBI-1 on calcium homeostasis, we evaluated sensitivity against cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase in AtBI-1-overexpressing or knock-down transgenic Arabidopsis plants.	cyclopiazonic acid	93-111	BAX inhibitor 1	Arabidopsis thaliana	185-191
17142482-6	2007	To investigate the effect of AtBI-1 on calcium homeostasis, we evaluated sensitivity against cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase in AtBI-1-overexpressing or knock-down transgenic Arabidopsis plants.	cyclopiazonic acid	113-116	BAX inhibitor 1	Arabidopsis thaliana	185-191
17142482-8	2007	Furthermore, AtBI-1-overexpressing cells demonstrated an attenuated rise in cytosolic calcium following CPA or H2O2 treatment, suggesting that AtBI-1 affects ion homeostasis in plant cell death regulation.	cyclopiazonic acid	104-107	BAX inhibitor 1	Arabidopsis thaliana	13-19
17142482-8	2007	Furthermore, AtBI-1-overexpressing cells demonstrated an attenuated rise in cytosolic calcium following CPA or H2O2 treatment, suggesting that AtBI-1 affects ion homeostasis in plant cell death regulation.	cyclopiazonic acid	104-107	BAX inhibitor 1	Arabidopsis thaliana	143-149
16987424-10	2006	siRNA targeted at STIM1 resulted in a reduction of SOC associated Ca2+ influx in response to store depletion by cyclopiazonic acid (60%) or histamine but not bradykinin.	cyclopiazonic acid	112-130	stromal interaction molecule 1	Homo sapiens	18-23
16971542-6	2006	Pretreatment of acute slices with the specific Ca2+-independent phospholipase A2 (iPLA2) inhibitor bromoenol lactone (BEL) (25 microM) blocked the CPA- and the CMZ-induced Ca2+ influx.	cyclopiazonic acid	147-150	phospholipase A2 group VI	Rattus norvegicus	47-80
16971542-6	2006	Pretreatment of acute slices with the specific Ca2+-independent phospholipase A2 (iPLA2) inhibitor bromoenol lactone (BEL) (25 microM) blocked the CPA- and the CMZ-induced Ca2+ influx.	cyclopiazonic acid	147-150	phospholipase A2 group VI	Rattus norvegicus	82-87
16971542-8	2006	CPA or CMZ enhanced the BEL-sensitive enzymatic activity of iPLA2 in cerebellar astrocyte culture.	cyclopiazonic acid	0-3	phospholipase A2 group VI	Rattus norvegicus	60-65
16770321-6	2006	In inside-out patches where SOCs were activated by CPA or the PKC activator phorbol-12,13-dibutyrate (PDBu), bath application of CaM induced an initial inhibition followed by an increase in SOC activity.	cyclopiazonic acid	51-54	calmodulin	Oryctolagus cuniculus	129-132
16582935-16	2006	Similarly, both in control and CPA-treated CSM preparations, spontaneous Ca transients were accelerated by noradrenaline (NAd, 1 microM) and were suppressed by 3-morpholino-sydnonimine (SIN-1, 10 microM), a nitric oxide (NO) donor.	cyclopiazonic acid	31-34	MAPK associated protein 1	Homo sapiens	186-191
16604358-11	2006	Furthermore, CPA-induced Chop mRNA expression and beta cell apoptosis were potentiated in cells that had been pretreated with IFN-gamma.	cyclopiazonic acid	13-16	DNA-damage inducible transcript 3	Rattus norvegicus	25-29
16604358-11	2006	Furthermore, CPA-induced Chop mRNA expression and beta cell apoptosis were potentiated in cells that had been pretreated with IFN-gamma.	cyclopiazonic acid	13-16	interferon gamma	Rattus norvegicus	126-135
16604358-12	2006	CONCLUSIONS/INTERPRETATION: CPA-induced endoplasmic reticulum stress and apoptosis is enhanced in IFN-gamma-treated beta cells.	cyclopiazonic acid	28-31	interferon gamma	Rattus norvegicus	98-107
16185686-5	2005	PACAP-27 effects were significantly inhibited by U-73122, phopholipase C (PLC) inhibitor, by 2-aminoethoxy-diphenylborate (2-APB), permeable blocker of inositol 1,4,5-triphosphate (IP3) receptors and by depletion of Ca2+ stores with cyclopiazonic acid or thapsigargin.	cyclopiazonic acid	233-251	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
16643279-6	2006	In particular, cyclopiazonic acid restores a 2-aminoethyoxydiphenyl borate-sensitive F508del-CFTR trafficking with an EC50 of 915 nm.	cyclopiazonic acid	15-33	CF transmembrane conductance regulator	Homo sapiens	93-97
16399701-8	2006	Direct measurement of Ca2+ in the endoplasmic reticulum (ER) lumen revealed that PKC increased the rate of store refilling more than twofold after depletion by treatment with cyclopiazonic acid.	cyclopiazonic acid	175-193	protein kinase C, gamma	Rattus norvegicus	81-84
15993905-7	2005	The muscarine-induced depression of NMDA current was prevented by blocking G-protein function or after depleting intracellular Ca2+ stores with cyclopiazonic acid.	cyclopiazonic acid	144-162	carbonic anhydrase 2	Homo sapiens	127-130
16153637-2	2005	Hence, we have studied the ability of serum albumin to prevent apoptosis of human neuroblastoma SH-SY 5 Y cells elicited by four compounds known to release Ca(2+) from the endoplasmic reticulum, i.e. dotarizine, flunarizine, thapsigargin and cyclopiazonic acid.	cyclopiazonic acid	242-260	albumin	Homo sapiens	38-51
15731188-3	2005	Thapsigargin and cyclopiazonic acid, which mobilize Ca(2+) from intracellular stores of the endoplasmic reticulum, evoked vasopressin release from dendrites and somata of magnocellular neurones in the supraoptic nucleus.	cyclopiazonic acid	17-35	arginine vasopressin	Rattus norvegicus	122-133
15659716-6	2005	Ryanodine, tetracaine, or cyclopiazonic acid each prevented CaMKII activation and significantly inhibited caffeine-induced relaxation.	cyclopiazonic acid	26-44	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	60-66
15701815-4	2005	SOCs were activated in these vessels using the sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) inhibitors cyclopiazonic acid and thapsigargin and were dose dependently blocked by the SOC antagonists Gd(3+) and 2-aminoethoxydiphenyl borate (2-APB) and the combined SOC/ROC antagonist SKF-96365.	cyclopiazonic acid	108-126	cytokine inducible SH2-containing protein	Rattus norvegicus	0-4
15875212-6	2005	Pretreatment of cells with the smooth endoplasmic reticulum Ca(2+) ATPase (SERCA) inhibitors cyclopiazonic acid (CPA) or thapsigargin completely abolished the effect of 10 microM DES on [Ca(2+)](i), while the IP(3) receptor blocker 2-aminoethoxydiphenyl borane (2-APB) had no effect.	cyclopiazonic acid	93-111	inositol 1,4,5-trisphosphate receptor type 3	Bos taurus	209-223
15875212-6	2005	Pretreatment of cells with the smooth endoplasmic reticulum Ca(2+) ATPase (SERCA) inhibitors cyclopiazonic acid (CPA) or thapsigargin completely abolished the effect of 10 microM DES on [Ca(2+)](i), while the IP(3) receptor blocker 2-aminoethoxydiphenyl borane (2-APB) had no effect.	cyclopiazonic acid	113-116	inositol 1,4,5-trisphosphate receptor type 3	Bos taurus	209-223
15731188-7	2005	Thus, exposure to Ca(2+) mobilizers such as thapsigargin or cyclopiazonic acid primes the releasable pool of vasopressin in the dendrites, so that release can subsequently be evoked by electrical and depolarization-dependent activation.	cyclopiazonic acid	60-78	arginine vasopressin	Rattus norvegicus	109-120
15474013-0	2004	Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding.	cyclopiazonic acid	0-18	carbonic anhydrase 2	Homo sapiens	54-57
15634940-9	2005	It was concluded that IL-4 did not inhibit transients in the presence of PI3K antagonists but that it did in the presence of CPA.	cyclopiazonic acid	125-128	interleukin 4	Bos taurus	22-26
15578732-7	2005	This is consistent with our finding that in cultured hippocampal neurons, stores depending on the activity of the sarcoendoplasmic reticulum Ca2+ ATPase (SERCA) pump had a low Ca2+ content, regardless of whether the neurons were challenged or not with K+ before applying the SERCA inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	291-309	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	114-152
15578732-7	2005	This is consistent with our finding that in cultured hippocampal neurons, stores depending on the activity of the sarcoendoplasmic reticulum Ca2+ ATPase (SERCA) pump had a low Ca2+ content, regardless of whether the neurons were challenged or not with K+ before applying the SERCA inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	291-309	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	154-159
15578732-7	2005	This is consistent with our finding that in cultured hippocampal neurons, stores depending on the activity of the sarcoendoplasmic reticulum Ca2+ ATPase (SERCA) pump had a low Ca2+ content, regardless of whether the neurons were challenged or not with K+ before applying the SERCA inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	311-314	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	114-152
15578732-7	2005	This is consistent with our finding that in cultured hippocampal neurons, stores depending on the activity of the sarcoendoplasmic reticulum Ca2+ ATPase (SERCA) pump had a low Ca2+ content, regardless of whether the neurons were challenged or not with K+ before applying the SERCA inhibitor cyclopiazonic acid (CPA).	cyclopiazonic acid	311-314	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	154-159
15476676-0	2004	The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.	cyclopiazonic acid	16-34	RNA binding motif single stranded interacting protein 1	Homo sapiens	80-84
15476676-1	2004	In the presence of external Ca2+, pretreatment of neutrophils with 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1) inhibited the cyclopiazonic acid (CPA)-induced [Ca2+](i) elevation in a concentration- but not a time-dependent manner, while YC-1 had no effect on the Ca2+ signals in a Ca2+-free medium.	cyclopiazonic acid	136-154	RNA binding motif single stranded interacting protein 1	Homo sapiens	116-120
15476676-1	2004	In the presence of external Ca2+, pretreatment of neutrophils with 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1) inhibited the cyclopiazonic acid (CPA)-induced [Ca2+](i) elevation in a concentration- but not a time-dependent manner, while YC-1 had no effect on the Ca2+ signals in a Ca2+-free medium.	cyclopiazonic acid	136-154	RNA binding motif single stranded interacting protein 1	Homo sapiens	248-252
15476676-1	2004	In the presence of external Ca2+, pretreatment of neutrophils with 3-(5"-hydroxymethyl-2"-furyl)-1-benzyl indazole (YC-1) inhibited the cyclopiazonic acid (CPA)-induced [Ca2+](i) elevation in a concentration- but not a time-dependent manner, while YC-1 had no effect on the Ca2+ signals in a Ca2+-free medium.	cyclopiazonic acid	156-159	RNA binding motif single stranded interacting protein 1	Homo sapiens	116-120
15476676-3	2004	Addition of YC-1 after cell activation strongly inhibited the CPA-induced [Ca2+](i) changes.	cyclopiazonic acid	62-65	RNA binding motif single stranded interacting protein 1	Homo sapiens	12-16
15476676-8	2004	Inhibition by YC-1 of CPA-induced [Ca2+](i) changes was not prevented by 7-nitroindazole and N-(3-aminomethyl)benzylacetamidine (1400W), two nitric oxide synthase (NOS) inhibitors, by aristolochic acid, a phospholipase A(2) inhibitor, or by suspension in a Na(+)-deprived medium.	cyclopiazonic acid	22-25	RNA binding motif single stranded interacting protein 1	Homo sapiens	14-18
15220115-7	2004	However, the active tension due to capacitative Ca2+ entry (CCE) induced by cyclopiazonic acid was significantly enhanced in PA rings overexpressing hTRPC1 (91 +/- 13% of 40K-induced contraction) compared with rings infected with an empty adenoviral vector (61 +/- 14%, P < 0.001).	cyclopiazonic acid	76-94	transient receptor potential cation channel subfamily C member 1	Homo sapiens	149-155
15474013-1	2004	The mycotoxin cyclopiazonic acid (CPA) is a potent inhibitor of the sarcoplasmic reticulum Ca2+-ATPase.	cyclopiazonic acid	34-37	carbonic anhydrase 2	Homo sapiens	91-94
15474013-3	2004	Furthermore, CPA abolishes the cooperativity of Ca2+ transport, showing a Ca2+/ATP ratio approximately 1 at any extent of Ca2+ saturation.	cyclopiazonic acid	13-16	carbonic anhydrase 2	Homo sapiens	48-51
15474013-3	2004	Furthermore, CPA abolishes the cooperativity of Ca2+ transport, showing a Ca2+/ATP ratio approximately 1 at any extent of Ca2+ saturation.	cyclopiazonic acid	13-16	carbonic anhydrase 2	Homo sapiens	74-77
15474013-3	2004	Furthermore, CPA abolishes the cooperativity of Ca2+ transport, showing a Ca2+/ATP ratio approximately 1 at any extent of Ca2+ saturation.	cyclopiazonic acid	13-16	carbonic anhydrase 2	Homo sapiens	74-77
15355851-6	2005	Thus the amplitude of I(ClCa) was diminished by the SR-ATPase inhibitor cyclopiazonic acid, the inositol 1,4,5-trisphosphate receptor antagonist 2-aminoethoxydiphenyl borate (2-APB), and the ryanodine receptor blocker tetracaine.	cyclopiazonic acid	72-90	arginyl aminopeptidase (aminopeptidase B)	Mus musculus	177-180
15476676-12	2004	YC-1 alone resulted in the accumulation of actin filaments in neutrophils, while significantly reduced the intensity of actin filament staining in the subsequent activation with CPA.	cyclopiazonic acid	178-181	RNA binding motif single stranded interacting protein 1	Homo sapiens	0-4
15476676-13	2004	These results indicate that YC-1 inhibited CPA-activated store-operated Ca2+ entry (SOCE) probably through the direct blockade of channel activation and/or the disruption of the integrity of the actin cytoskeleton necessary for supporting Ca2+ entry pathway in neutrophils.	cyclopiazonic acid	43-46	RNA binding motif single stranded interacting protein 1	Homo sapiens	28-32
15474013-4	2004	There is also an effect on the Ca2+-binding mechanism, where the addition of CPA results in binding of only half-maximal amount of Ca2+ observed in its absence.	cyclopiazonic acid	77-80	carbonic anhydrase 2	Homo sapiens	31-34
15474013-0	2004	Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding.	cyclopiazonic acid	0-18	carbonic anhydrase 2	Homo sapiens	76-79
15474013-4	2004	There is also an effect on the Ca2+-binding mechanism, where the addition of CPA results in binding of only half-maximal amount of Ca2+ observed in its absence.	cyclopiazonic acid	77-80	carbonic anhydrase 2	Homo sapiens	131-134
15474013-5	2004	The experimental data suggest that in the presence of CPA, only a single Ca2+ ion binds to the Ca2+-ATPase.	cyclopiazonic acid	54-57	carbonic anhydrase 2	Homo sapiens	73-76
14988079-8	2004	Cyclopiazonic acid (CPA; 30 microM) significantly reduced the DeltamMVo(2) to 0.27 +/- 0.06 ml O(2).min(-1).100 g LV(-1) (35% of control).	cyclopiazonic acid	0-18	carboxypeptidase A1, pancreatic	Mus musculus	20-23
15474013-5	2004	The experimental data suggest that in the presence of CPA, only a single Ca2+ ion binds to the Ca2+-ATPase.	cyclopiazonic acid	54-57	carbonic anhydrase 2	Homo sapiens	95-98
32585778-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 muM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca2+-free/EGTA (1 mM) bath solution, than IDHPG, suggesting that these responses are, in the main part, mediated by distinct processes.	cyclopiazonic acid	138-156	carbonic anhydrase 2	Rattus norvegicus	18-21
15126052-11	2004	When cells were exposed to cyclopiazonic acid (CPA) to release SR calcium stores, P(o) increased slowly, then persisted at large values.	cyclopiazonic acid	27-45	carboxypeptidase A1	Homo sapiens	47-50
15111012-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 microM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca(2+)-free/EGTA (1 mM) bath solution, than I(DHPG), suggesting that these responses are, in the main part, mediated by distinct processes.	cyclopiazonic acid	138-156	carbonic anhydrase 2	Rattus norvegicus	18-21
32585778-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 muM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca2+-free/EGTA (1 mM) bath solution, than IDHPG, suggesting that these responses are, in the main part, mediated by distinct processes.	cyclopiazonic acid	138-156	carbonic anhydrase 2	Rattus norvegicus	74-77
32585778-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 muM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca2+-free/EGTA (1 mM) bath solution, than IDHPG, suggesting that these responses are, in the main part, mediated by distinct processes.	cyclopiazonic acid	138-156	carbonic anhydrase 2	Rattus norvegicus	74-77
32585778-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 muM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca2+-free/EGTA (1 mM) bath solution, than IDHPG, suggesting that these responses are, in the main part, mediated by distinct processes.	cyclopiazonic acid	138-156	carbonic anhydrase 2	Rattus norvegicus	74-77
32585778-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 muM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca2+-free/EGTA (1 mM) bath solution, than IDHPG, suggesting that these responses are, in the main part, mediated by distinct processes.	cyclopiazonic acid	138-156	carbonic anhydrase 2	Rattus norvegicus	74-77
12388076-8	2003	Cyclopiazonic acid (CPA), which inhibits endoplasmic reticulum (ER) Ca(2+) pumps and unloads the ER, induces transient (in Ca(2+)-free media) or sustained (in Ca(2+)-replete media) elevation of [Ca(2+)](cyt).	cyclopiazonic acid	0-18	carboxypeptidase A1, pancreatic	Mus musculus	20-23
15094326-9	2004	Relaxation induced by VIP was reduced in tissues contracted by either TSG or CPA in the presence of nifedipine or verapamil.	cyclopiazonic acid	77-80	vasoactive intestinal peptide	Rattus norvegicus	22-25
12887970-5	2003	Both the peak and plateau component of the ET-1 calcium response were abolished by PD145065, an ET receptor antagonist, and by cyclopiazonic acid (CPA) (10 microM).	cyclopiazonic acid	127-145	endothelin 1	Homo sapiens	43-47
12887970-5	2003	Both the peak and plateau component of the ET-1 calcium response were abolished by PD145065, an ET receptor antagonist, and by cyclopiazonic acid (CPA) (10 microM).	cyclopiazonic acid	147-150	endothelin 1	Homo sapiens	43-47
14650578-1	2003	The effect of cyclopiazonic acid (CPA) on changes in the intracellular free Ca2+ concentration ([Ca2+]i) evoked by bradykinin (BK), histamine (HIST) and thapsigargin (TG) was investigated in human gingival fibroblasts.	cyclopiazonic acid	14-32	kininogen 1	Homo sapiens	115-125
14650578-1	2003	The effect of cyclopiazonic acid (CPA) on changes in the intracellular free Ca2+ concentration ([Ca2+]i) evoked by bradykinin (BK), histamine (HIST) and thapsigargin (TG) was investigated in human gingival fibroblasts.	cyclopiazonic acid	34-37	kininogen 1	Homo sapiens	115-125
14650578-3	2003	Pretreatment with CPA (< 5 microM) enhanced the [Ca2+]i responses evoked by 5 nM BK and 1 mM HIST.	cyclopiazonic acid	18-21	kininogen 1	Homo sapiens	84-86
12424093-2	2003	ANG II partially reversed the increase in [Ca(2+)](i) generated by cyclopiazonic acid (CPA; 10(-5) M), acetylcholine (ACh; 10(-5) M), or bradykinin (BK; 10(-7) M).	cyclopiazonic acid	67-85	angiogenin	Homo sapiens	0-3
12424093-2	2003	ANG II partially reversed the increase in [Ca(2+)](i) generated by cyclopiazonic acid (CPA; 10(-5) M), acetylcholine (ACh; 10(-5) M), or bradykinin (BK; 10(-7) M).	cyclopiazonic acid	87-90	angiogenin	Homo sapiens	0-3
14650578-5	2003	Moreover, CPA accelerated the Ca2+ influx caused by 5 nM BK and 1mM HIST, but did not alter that caused by 1 microM TG.	cyclopiazonic acid	10-13	kininogen 1	Homo sapiens	57-59
12759219-0	2003	Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid.	cyclopiazonic acid	103-121	lipase E, hormone sensitive type	Rattus norvegicus	0-24
12829639-4	2003	Treatment with thapsigargin or cyclopiazonic acid, inhibitors of the sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) pumps, nearly doubled the peak and slowed the decay of the depolarization-induced Ca(2+) transients.	cyclopiazonic acid	31-49	ATPase, Ca++ transporting, ubiquitous	Mus musculus	69-110
12829639-4	2003	Treatment with thapsigargin or cyclopiazonic acid, inhibitors of the sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) pumps, nearly doubled the peak and slowed the decay of the depolarization-induced Ca(2+) transients.	cyclopiazonic acid	31-49	ATPase, Ca++ transporting, ubiquitous	Mus musculus	112-117
12515718-3	2003	SERCA inhibitors di-tert-butyl-benzohydroquinone (tBHQ), thapsigargin, and cyclopiazonic acid significantly enhanced the induction of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and CD11b marker expression induced by suboptimal concentrations of ATRA (50 nM) in both cell lines.	cyclopiazonic acid	75-93	integrin subunit alpha M	Homo sapiens	207-212
12615969-6	2003	The change in IP(3)R1 localization induced by arginine-vasopressin could be blocked by the simultaneous addition of nocodazole or taxol and depended on Ca(2+) release from intracellular stores since Ca(2+)-mobilizing agents such as thapsigargin and cyclopiazonic acid could induce the redistribution.	cyclopiazonic acid	249-267	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	14-21
12615969-6	2003	The change in IP(3)R1 localization induced by arginine-vasopressin could be blocked by the simultaneous addition of nocodazole or taxol and depended on Ca(2+) release from intracellular stores since Ca(2+)-mobilizing agents such as thapsigargin and cyclopiazonic acid could induce the redistribution.	cyclopiazonic acid	249-267	arginine vasopressin	Rattus norvegicus	55-66
12388060-4	2003	In Xenopus oocytes, CN also induced Ca(2+) release and activated I(Cl(Ca)), and these responses were inhibited by thapsigargin and cyclopiazonic acid to deplete sarcoplasmic reticulum (SR) Ca(2+), whereas neither heparin nor anti-inositol 1,4,5-trisphosphate receptor (IP(3)R) antibodies affected CN responses.	cyclopiazonic acid	131-149	inositol 1,4,5-trisphosphate receptor type 1 S homeolog	Xenopus laevis	269-275
12504779-7	2003	In contrast, 2-aminoethyldiphenyl borate (2-APB) diminished cyclopiazonic acid-but enhanced GEA3162-induced [Ca(2+)](i) change.	cyclopiazonic acid	60-78	arginyl aminopeptidase	Rattus norvegicus	44-47
12359635-9	2002	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid (CPA) produced a more robust effect.	cyclopiazonic acid	69-87	ATPase, Ca++ transporting, ubiquitous	Mus musculus	4-45
12359637-4	2002	The contractions elicited by 10 micro M CPA required an intact endothelium, were dependent upon external Ca(2+) and were prevented by 10 micro M indomethacin, the inhibitor of prostaglandin synthesis, or 1 micro M SQ29548, the specific prostaglandin H2/thromboxane A2 (PGH2/TXA2) receptor blocker.	cyclopiazonic acid	40-43	histocompatibility-2, MHC	Mus musculus	250-267
12359635-9	2002	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid (CPA) produced a more robust effect.	cyclopiazonic acid	69-87	ATPase, Ca++ transporting, ubiquitous	Mus musculus	47-52
12359635-9	2002	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid (CPA) produced a more robust effect.	cyclopiazonic acid	89-92	ATPase, Ca++ transporting, ubiquitous	Mus musculus	4-45
12359635-9	2002	The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) pump inhibitor cyclopiazonic acid (CPA) produced a more robust effect.	cyclopiazonic acid	89-92	ATPase, Ca++ transporting, ubiquitous	Mus musculus	47-52
12379176-8	2002	Using the patch-clamp technique, store-operated Ca(2+) currents (I(SOC)) could be recorded in cells treated with ACh or CPA, but voltage-operated Ca(2+) currents (VOCCs) were not elicited in most of the cells (17/20), but in 15% of cells examined, small dihydropyridine (DHP)-sensitive Ca(2+) currents were recorded.	cyclopiazonic acid	120-123	dihydropyrimidinase	Homo sapiens	271-274
11304465-8	2001	Transfection with MLCK antisense completely prevented CCE in response to thapsigargin and cyclopiazonic acid, whereas MLCK sense had no effect.	cyclopiazonic acid	90-108	myosin light chain kinase	Homo sapiens	18-22
11964597-5	2002	Ca2+ influx via NCX was examined during rapid activation in the presence of the reversible SR Ca2+ adenosine triphosphatase inhibitor cyclopiazonic acid and ryanodine to inhibit the SR. Efflux mode NCX was examined during activation by extracellular Na+ in the absence of SR reuptake.	cyclopiazonic acid	134-152	solute carrier family 8 member A1	Rattus norvegicus	16-19
11707692-10	2001	The vasodilator effects of bradykinin and cyclopiazonic acid were dose-dependently inhibited by insulin.	cyclopiazonic acid	42-60	insulin	Homo sapiens	96-103
11559781-7	2001	Inhibition of SERCA with cyclopiazonic acid (CPA) abolished these differences between WT and PLB-KO bladder, localizing the effects to the SR. 3.	cyclopiazonic acid	25-43	phospholamban	Mus musculus	93-96
11559781-7	2001	Inhibition of SERCA with cyclopiazonic acid (CPA) abolished these differences between WT and PLB-KO bladder, localizing the effects to the SR. 3.	cyclopiazonic acid	45-48	phospholamban	Mus musculus	93-96
11350748-5	2001	Inhibition of phospholipase C (PLC) with U-73122 or inhibition of endoplasmic reticulum Ca(2+)-ATPase with cyclopiazonic acid or thapsigargin abolished the rise of ([Ca2+](i)).	cyclopiazonic acid	107-125	carbonic anhydrase 2	Homo sapiens	166-169
11861657-4	2002	Moreover like for the worm Pmr1 Ca(2+) pump expressed in COS-1 cells, Ca(2+) accumulation into the endogenous tg-insensitive store showed a 2 orders of magnitude lower sensitivity to cyclopiazonic acid than the SERCA-mediated transport.	cyclopiazonic acid	183-201	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	27-31
11535685-10	2001	Thapsigargin (10 microM) and cyclopiazonic acid (30 microM), inhibitors of sarco-endoplasmic reticulum Ca2+-ATPase, had little effect on either the inward current or the elevation in [Ca2+](i) induced by 3,5-DHPG.	cyclopiazonic acid	29-47	ATPase, Ca++ transporting, ubiquitous	Mus musculus	75-114
11470472-7	2001	RESULTS: When stimulated with cyclopiazonic acid, a SERCA-2 inhibitor, T3-deprived cardiomyocytes showed significantly faster (P=0.03) and more transient (P=0.04) increases in [Ca(2+)](i) than T3-supplemented cells.	cyclopiazonic acid	30-48	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	52-59
11558374-2	2001	The changes in cytosol Ca2+ concentration associated with the shrinkage of Arabidopsis cells induced by the inhibitor of Ca(2+)-ATPase, cyclopiazonic acid and the Ca2+ ionophore ionomycin were monitored using the fluorescence of Ca(2+)-sensitive probe chlortetracycline hydrochloride.	cyclopiazonic acid	136-154	carbonic anhydrase 2	Arabidopsis thaliana	23-26
11642046-2	2001	It is proved that the ATP-ase of actomyosine is nonselectively inhibited by thapsigargin (imaginary inhibition constant Ki is equal 29.4 +/- 5.2 nM), cyclopiazonic acid (Ki = 626 +/- 118 nM), eosin Y (Ki = 70 +/- 14 nM) and p-chlormercurybenzoate (Ki = 380 +/- 151 nM).	cyclopiazonic acid	150-168	dynein axonemal heavy chain 8	Homo sapiens	22-29
11158972-5	2001	In the presence of Ni(2+), which inhibits Ca(2+) influx through nonselective cation channels, the BK-induced EDHF relaxant response was greatly diminished and the CPA-induced response was abolished.	cyclopiazonic acid	163-166	kininogen 1	Homo sapiens	98-100
10951390-9	2000	The marked inhibitory effect of ophiobolin A and W7 on the activation of CPA-treated pig oocytes suggests that the calcium signal, as the second messenger, acts downstream through calmodulin.	cyclopiazonic acid	73-76	calmodulin-3	Sus scrofa	180-190
10894799-2	2000	For this purpose we characterized the effects of the endoplasmatic Ca(2+)-ATPase inhibitors thapsigargin (300 nM) and cyclopiazonic acid (20 microM) on renin secretion from isolated perfused rat kidneys.	cyclopiazonic acid	118-136	renin	Rattus norvegicus	152-157
10952916-5	2000	The augmentation of contractile activity in laboring myometrium in the presence of a SERCA 2 inhibitor, cyclopiazonic acid (CPA), demonstrated the functional significance of this observation.	cyclopiazonic acid	104-122	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	85-92
10952916-5	2000	The augmentation of contractile activity in laboring myometrium in the presence of a SERCA 2 inhibitor, cyclopiazonic acid (CPA), demonstrated the functional significance of this observation.	cyclopiazonic acid	124-127	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	85-92
10896718-12	2000	In the presence of the endoplasmic reticulum Ca2+-ATPase inhibitor cyclopiazonic acid (10 microM) in Ca2+-free media, the [Ca2+]i responses evoked by ATP were progressively decreased and abolished.	cyclopiazonic acid	67-85	carbonic anhydrase 2	Rattus norvegicus	45-48
10896718-12	2000	In the presence of the endoplasmic reticulum Ca2+-ATPase inhibitor cyclopiazonic acid (10 microM) in Ca2+-free media, the [Ca2+]i responses evoked by ATP were progressively decreased and abolished.	cyclopiazonic acid	67-85	carbonic anhydrase 2	Rattus norvegicus	101-104
10896718-12	2000	In the presence of the endoplasmic reticulum Ca2+-ATPase inhibitor cyclopiazonic acid (10 microM) in Ca2+-free media, the [Ca2+]i responses evoked by ATP were progressively decreased and abolished.	cyclopiazonic acid	67-85	carbonic anhydrase 2	Rattus norvegicus	101-104
10970769-7	2000	SERCA2-pump inhibitors thapsigargin and cyclopiazonic acid showed a concentration-dependent inhibition of nuclear Ca(2+)loading.	cyclopiazonic acid	40-58	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Gallus gallus	0-6
11483290-1	2000	The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE).	cyclopiazonic acid	88-106	angiotensinogen	Homo sapiens	173-187
11483290-1	2000	The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE).	cyclopiazonic acid	88-106	angiotensinogen	Homo sapiens	189-195
11483290-1	2000	The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE).	cyclopiazonic acid	108-111	angiotensinogen	Homo sapiens	173-187
11483290-1	2000	The current study was performed to determine the effect of calcium store depletion with cyclopiazonic acid (CPA) on the pre- and postglomerular vasoconstrictor responses to angiotensin II (ANG II) and norepinephrine (NE).	cyclopiazonic acid	108-111	angiotensinogen	Homo sapiens	189-195
11483290-2	2000	CPA treatment significantly attenuated the afferent arteriolar response to 10 nM ANG II by 51% and to 1000 nM NE by 19%.	cyclopiazonic acid	0-3	angiotensinogen	Homo sapiens	81-87
11483290-3	2000	Efferent arteriolar responses to ANG II and NE were also greatly attenuated in the presence of CPA.	cyclopiazonic acid	95-98	angiotensinogen	Homo sapiens	33-39
11483290-4	2000	These data demonstrate that afferent and efferent arteriolar responses to ANG II and NE depend on release of calcium from CPA-sensitive intracellular stores.	cyclopiazonic acid	122-125	angiotensinogen	Homo sapiens	74-80
10686507-1	2000	The effect of two Ca(2+) ATPase inhibitors, cyclopiazonic acid (CPA) and 2,5-di-(tert-butyl)-1,4-hydroquinone (DTBHQ), on the release of MCP-1 from bone marrow-derived mast cells (BMMCs) were investigated.	cyclopiazonic acid	44-62	mast cell protease 1	Mus musculus	137-142
10644044-3	2000	Other inhibitors of Ca(2+)-ATPases associated with intracellular calcium stores, such as cyclopiazonic acid and 2,5-di-(tert-butyl)-1,4-benzohydroquinone, equally inhibited IL-8-activated migration.	cyclopiazonic acid	89-107	C-X-C motif chemokine ligand 8	Homo sapiens	173-177
10686507-2	2000	CPA and DTBHQ increased the intracellular free Ca(2+) concentration ([Ca(2+)](i)) and induced MCP-1 release in a dose-dependent manner.	cyclopiazonic acid	0-3	mast cell protease 1	Mus musculus	94-99
10526106-3	1999	To investigate PAF-induced Ca(2+) influx, the contents of intracellular stores were modulated using the SERCA blocker cyclopiazonic acid (CPA).	cyclopiazonic acid	138-141	PCNA clamp associated factor	Homo sapiens	15-18
10516641-15	1999	These data show that dotarizine shares with thapsigargin and CPA the ability to deplete Ca2+ in the ER; this novel action of dotarizine could be relevant to its prophylactic effects in migraine.	cyclopiazonic acid	61-64	carbonic anhydrase 2	Bos taurus	88-91
10516641-5	1999	This transient rise of [Ca2+]c was mimicked by 1 microM thapsigargin and by 30 microM cyclopiazonic acid (CPA), but not by 30 microM flunarizine.	cyclopiazonic acid	86-104	carbonic anhydrase 2	Bos taurus	24-27
10516641-5	1999	This transient rise of [Ca2+]c was mimicked by 1 microM thapsigargin and by 30 microM cyclopiazonic acid (CPA), but not by 30 microM flunarizine.	cyclopiazonic acid	106-109	carbonic anhydrase 2	Bos taurus	24-27
10511129-9	1999	The SR Ca2+ pump inhibitor, cyclopiazonic acid, abolished, and removal of extracellular Ca2+ attenuated, the response to AVP.	cyclopiazonic acid	28-46	arginine vasopressin	Rattus norvegicus	121-124
10526106-8	1999	Nevertheless, Ca(2+)-release induced by PAF (or CPA) serves as an important factor in controlling Ca(2+) entry presumably mediated by activation of store-operated-Ca(2+) channels.	cyclopiazonic acid	48-51	PCNA clamp associated factor	Homo sapiens	40-43
10395082-7	1999	AVP evoked an increase in [Ca2+]i levels (162 +/- 12 nmol/L from a basal value of 77 +/- 6 nmol/L) which was completely abolished by pretreatment with either NCDC or cyclopiazonic acid (sarcoplasmic reticulum (SR) Ca2+ pump inhibitor) but unaffected by ryanodine (ryanodine sensitive SR Ca2+ store depletor).	cyclopiazonic acid	166-184	arginine vasopressin	Rattus norvegicus	0-3
10454695-7	1999	The oxytocin-stimulated intracellular free calcium increase resulting from calcium entry was blocked by store depletion by thapsigargin or cyclopiazonic acid, consistent with a capacitative calcium entry mechanism.	cyclopiazonic acid	139-157	oxytocin/neurophysin I prepropeptide	Homo sapiens	4-12
10422640-5	1999	In WKY and SHR endothelium-intact aortas contracted with either phenylephrine or endothelin-1, carbachol and cyclopiazonic acid evoked endothelium derived relaxing factor (EDRF)/nitric oxide (NO)-dependent relaxations which were reduced by pretreatment of the rings with methyl-2,5-dihydroxycinnamate or genistein.	cyclopiazonic acid	109-127	endothelin 1	Rattus norvegicus	81-93
10415113-6	1999	In HA-1 cells, adapt78 mRNA was induced by the calcium ionophore A23187, 2-deoxyglucose, brefeldin A, tunicamycin, thapsigargin, and cyclopiazonic acid, with thapsigargin being the most potent inducer (7.3-fold).	cyclopiazonic acid	133-151	regulator of calcineurin 1	Homo sapiens	15-22
10400636-4	1999	Blocking the SERCA pump with thapsigargin or cyclopiazonic acid accelerated the rising phase of [Ca2+]c oscillations and increased their amplitude, which suggests that the endoplasmic reticulum (ER) rapidly takes up Ca2+.	cyclopiazonic acid	45-63	carbonic anhydrase 2	Mus musculus	97-100
10400636-4	1999	Blocking the SERCA pump with thapsigargin or cyclopiazonic acid accelerated the rising phase of [Ca2+]c oscillations and increased their amplitude, which suggests that the endoplasmic reticulum (ER) rapidly takes up Ca2+.	cyclopiazonic acid	45-63	carbonic anhydrase 2	Mus musculus	216-219
10341236-8	1999	In addition, thapsigargin, ryanodine, and cyclopiazonic acid reduced action potential-evoked Ca2+ transients in the absence of caffeine.	cyclopiazonic acid	42-60	carbonic anhydrase 2	Homo sapiens	93-96
10397175-5	1999	In spite of this, we demonstrated in this paper that in ELM-I-1 cells the Epo-induced down-regulation of c-myb expression and hemoglobin production can be effectively enhanced by the simultaneously added [Ca2+]i-increasing agent, cyclopiazonic acid (CPA).	cyclopiazonic acid	230-248	erythropoietin	Mus musculus	74-77
10397175-5	1999	In spite of this, we demonstrated in this paper that in ELM-I-1 cells the Epo-induced down-regulation of c-myb expression and hemoglobin production can be effectively enhanced by the simultaneously added [Ca2+]i-increasing agent, cyclopiazonic acid (CPA).	cyclopiazonic acid	230-248	myeloblastosis oncogene	Mus musculus	105-110
10397175-5	1999	In spite of this, we demonstrated in this paper that in ELM-I-1 cells the Epo-induced down-regulation of c-myb expression and hemoglobin production can be effectively enhanced by the simultaneously added [Ca2+]i-increasing agent, cyclopiazonic acid (CPA).	cyclopiazonic acid	250-253	erythropoietin	Mus musculus	74-77
10397175-5	1999	In spite of this, we demonstrated in this paper that in ELM-I-1 cells the Epo-induced down-regulation of c-myb expression and hemoglobin production can be effectively enhanced by the simultaneously added [Ca2+]i-increasing agent, cyclopiazonic acid (CPA).	cyclopiazonic acid	250-253	myeloblastosis oncogene	Mus musculus	105-110
10330030-4	1999	The sarcoplasmic reticulum (SR) Ca2+-pump inhibitor cyclopiazonic acid (CPA; 10 microM) evoked Ca2+ transients and contractions but not membrane currents.	cyclopiazonic acid	52-70	carbonic anhydrase 2	Canis lupus familiaris	32-35
10330030-4	1999	The sarcoplasmic reticulum (SR) Ca2+-pump inhibitor cyclopiazonic acid (CPA; 10 microM) evoked Ca2+ transients and contractions but not membrane currents.	cyclopiazonic acid	52-70	carbonic anhydrase 2	Canis lupus familiaris	95-98
10330030-4	1999	The sarcoplasmic reticulum (SR) Ca2+-pump inhibitor cyclopiazonic acid (CPA; 10 microM) evoked Ca2+ transients and contractions but not membrane currents.	cyclopiazonic acid	72-75	carbonic anhydrase 2	Canis lupus familiaris	32-35
10330030-4	1999	The sarcoplasmic reticulum (SR) Ca2+-pump inhibitor cyclopiazonic acid (CPA; 10 microM) evoked Ca2+ transients and contractions but not membrane currents.	cyclopiazonic acid	72-75	carbonic anhydrase 2	Canis lupus familiaris	95-98
10188631-18	1999	These results show that NA-induced contractions of the epididymal and prostatic parts of the rat vas deferens differ in sensitivity to ryanodine or CPA.	cyclopiazonic acid	148-151	arginine vasopressin	Rattus norvegicus	97-100
10064040-1	1999	Malignant hyperthermia (MH) and the mycotoxin cyclopiazonic acid (CPA) are each associated with abnormal calcium homeostasis in skeletal muscle, a key underlying factor in the development of pale, soft, and exudative (PSE) pork.	cyclopiazonic acid	66-69	PSE	Sus scrofa	218-221
9932728-2	1999	We found that activity and mobility on electrophoresis gels of the cPLA2 protein were significantly increased by f-Met-Leu-Phe (fMLP), 12-myristate 13-acetate (PMA) and the Ca2+-ATPase inhibitors, thapsigargin and cyclopiazonic acid.	cyclopiazonic acid	214-232	phospholipase A2 group IVA	Homo sapiens	67-72
9932728-2	1999	We found that activity and mobility on electrophoresis gels of the cPLA2 protein were significantly increased by f-Met-Leu-Phe (fMLP), 12-myristate 13-acetate (PMA) and the Ca2+-ATPase inhibitors, thapsigargin and cyclopiazonic acid.	cyclopiazonic acid	214-232	formyl peptide receptor 1	Homo sapiens	128-132
9932728-6	1999	However, the thapsigargin- and cyclopiazonic acid-induced cPLA2 activation was completely inhibited by the tyrosine kinase inhibitor, erbstatin, and Ca2+ chelator, EGTA.	cyclopiazonic acid	31-49	phospholipase A2 group IVA	Homo sapiens	58-63
10064040-6	1999	During the second trial, conducted under extreme outside temperatures (-18 degrees C), CPA-dependent reductions (P<.05) in feed intake, average daily gain, and 45-min pH in nn hogs support the possibility of interactions between malignant hyperthermia and dietary CPA on skeletal muscle calcium homeostasis and the development of PSE pork.	cyclopiazonic acid	87-90	PSE	Sus scrofa	333-336
9865597-2	1998	CPA, DTBHQ and DTAHQ, all of which induce intracellular free Ca2+ concentration ([Ca2+]i) increase, induced IL-4 and MCP-1 release in a dose-dependent manner.	cyclopiazonic acid	0-3	interleukin 4	Rattus norvegicus	108-112
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	cyclopiazonic acid	62-80	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	4-43
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	cyclopiazonic acid	62-80	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	45-50
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	cyclopiazonic acid	62-80	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	177-181
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	cyclopiazonic acid	82-85	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	4-43
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	cyclopiazonic acid	82-85	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	45-50
9782161-5	1998	The sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor cyclopiazonic acid (CPA) dramatically affected oscillations whereas inhibition of the plasma membrane Ca2+-ATPase (PMCA) with La3+ had little effect.	cyclopiazonic acid	82-85	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	177-181
9782161-11	1998	For a Ca2+ transient, the initiation of release was suppressed by SERCA during either the lag phase or the interspike period (ISP) since: (i) the ISP was shortened by low CPA concentrations, (ii) higher concentrations of CPA stimulated an explosive Ca2+ release when applied during the ISP but not when applied in the absence of agonist, and (iii) CPA synchronized the initial Ca2+ response to a low histamine dose (even recruiting silent, histamine-unresponsive cells).	cyclopiazonic acid	171-174	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	66-71
9782161-11	1998	For a Ca2+ transient, the initiation of release was suppressed by SERCA during either the lag phase or the interspike period (ISP) since: (i) the ISP was shortened by low CPA concentrations, (ii) higher concentrations of CPA stimulated an explosive Ca2+ release when applied during the ISP but not when applied in the absence of agonist, and (iii) CPA synchronized the initial Ca2+ response to a low histamine dose (even recruiting silent, histamine-unresponsive cells).	cyclopiazonic acid	221-224	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	66-71
9782161-11	1998	For a Ca2+ transient, the initiation of release was suppressed by SERCA during either the lag phase or the interspike period (ISP) since: (i) the ISP was shortened by low CPA concentrations, (ii) higher concentrations of CPA stimulated an explosive Ca2+ release when applied during the ISP but not when applied in the absence of agonist, and (iii) CPA synchronized the initial Ca2+ response to a low histamine dose (even recruiting silent, histamine-unresponsive cells).	cyclopiazonic acid	221-224	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	66-71
9782161-13	1998	Two aspects of the regenerative upstroke of a spike were differently affected by SERCA inhibition: Ca2+ wave velocity was entirely unaffected by CPA whereas the local rate of rise was increased.	cyclopiazonic acid	145-148	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	81-86
9782161-15	1998	The [Ca2+]i at which a Ca2+ spike terminated depended on SERCA since CPA dose dependently enhanced the peak [Ca2+]i.	cyclopiazonic acid	69-72	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	57-62
9865597-2	1998	CPA, DTBHQ and DTAHQ, all of which induce intracellular free Ca2+ concentration ([Ca2+]i) increase, induced IL-4 and MCP-1 release in a dose-dependent manner.	cyclopiazonic acid	0-3	mast cell protease 1-like 1	Rattus norvegicus	117-122
9808725-0	1998	A high-affinity Ca2+ pump, ECA1, from the endoplasmic reticulum is inhibited by cyclopiazonic acid but not by thapsigargin.	cyclopiazonic acid	80-98	ER-type Ca2+-ATPase 1	Arabidopsis thaliana	27-31
9395254-7	1997	However, after depletion of adrenaline-sensitive Ca2+ pool by 10 microM Adr, CPA transiently elevated [Ca2+]i only in alpha1a and alpha1d transfected HEK-293 cells, not in alpha1b transfected HEK-293 cells.	cyclopiazonic acid	77-80	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	118-125
9655696-3	1998	The NO-donor SIN-1 and the cGMP analogs were able to inhibit contractions induced by activation of L-type Ca2+ channels (BAY-K-8644), by carbachol (CCh), and by cyclopiazonic acid (CPA), a blocker of sarcoplasmic Ca2+-ATPase.	cyclopiazonic acid	161-179	MAPK associated protein 1	Homo sapiens	13-18
9655696-3	1998	The NO-donor SIN-1 and the cGMP analogs were able to inhibit contractions induced by activation of L-type Ca2+ channels (BAY-K-8644), by carbachol (CCh), and by cyclopiazonic acid (CPA), a blocker of sarcoplasmic Ca2+-ATPase.	cyclopiazonic acid	181-184	MAPK associated protein 1	Homo sapiens	13-18
9655696-6	1998	After restoration of extracellular Ca2+, the inhibitory effect of SIN-1 and pCPT-cGMP was only attenuated, whereas in the additional presence of CPA, the inhibitory effect of SIN-1 was blocked and the effect of 8-BrcGMP reduced.	cyclopiazonic acid	145-148	MAPK associated protein 1	Homo sapiens	175-180
9610429-11	1997	Therefore, a large part of the response to [beta Ala8]NKA (4-10) persisted in the presence of both CPA and nifedipine.	cyclopiazonic acid	99-102	tachykinin precursor 1	Homo sapiens	54-57
9610429-15	1997	7 We conclude that, during sustained depolarization produced by the NK1 receptor agonist, blockade of the sarcoplasmic reticulum Ca pump by CPA produces a faster Ca-dependent inactivation of Ca channels, thereby eliminating spikes and abolishing the tonic component of contraction.	cyclopiazonic acid	140-143	substance-P receptor	Cavia porcellus	68-80
9326287-10	1997	The calcium reuptake inhibitors thapsigargin and cyclopiazonic acid potentiated caffeine-stimulated A beta release.	cyclopiazonic acid	49-67	amyloid beta precursor protein	Homo sapiens	100-106
9257912-12	1997	In such tissues cyclopiazonic acid (CPA; 10 microM) prevented Ca2+-induced recovery of vanadate-induced contraction.	cyclopiazonic acid	16-34	carbonic anhydrase 2	Homo sapiens	62-65
9257912-12	1997	In such tissues cyclopiazonic acid (CPA; 10 microM) prevented Ca2+-induced recovery of vanadate-induced contraction.	cyclopiazonic acid	36-39	carbonic anhydrase 2	Homo sapiens	62-65
9032683-11	1997	Depletion of internal Ca2+ stores by perifusion with thapsigargin or cyclopiazonic acid also reduced DAP amplitudes by approximately 50% and eliminated phasic patterns of firing.	cyclopiazonic acid	69-87	death-associated protein	Rattus norvegicus	101-104
9008638-9	1997	With a nominally Ca(2+)-free solution containing 10 microM cyclopiazonic acid, simultaneous 10(-6) M ET-1 and extracellular Ca2+ additions transiently increased [Ca2+]i twofold, whereas 10(-6) M S-6-c increased it by only 20%.	cyclopiazonic acid	59-77	endothelin 1	Bos taurus	101-105
9754866-4	1998	RESULTS: All Ca2--ATPase inhibitors (TG, CPA, DTBHQ and DTAHQ) induced TNF-alpha release in a dose-dependent manner.	cyclopiazonic acid	41-44	tumor necrosis factor	Rattus norvegicus	71-80
9754866-7	1998	TNF-alpha release induced by DTBHQ and CPA was inhibited by treatment with actinomycin-D, the immunosuppressant FK506 and the glucocorticoid dexamethasone (p < or = 0.01).	cyclopiazonic acid	39-42	tumor necrosis factor	Rattus norvegicus	0-9
9610429-0	1997	Effect of cyclopiazonic acid on contractions produced by tachykinin NK1 and NK2 receptor agonists in the circular muscle of guinea-pig colon.	cyclopiazonic acid	10-28	tachykinin receptor 1	Homo sapiens	68-71
9610429-0	1997	Effect of cyclopiazonic acid on contractions produced by tachykinin NK1 and NK2 receptor agonists in the circular muscle of guinea-pig colon.	cyclopiazonic acid	10-28	substance-K receptor	Cavia porcellus	76-88
9610429-1	1997	1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon.	cyclopiazonic acid	43-61	tachykinin receptor 1	Homo sapiens	190-193
9610429-1	1997	1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon.	cyclopiazonic acid	43-61	substance-K receptor	Cavia porcellus	198-210
9610429-1	1997	1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon.	cyclopiazonic acid	43-61	tachykinin precursor 1	Homo sapiens	281-284
9610429-1	1997	1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon.	cyclopiazonic acid	63-66	tachykinin receptor 1	Homo sapiens	190-193
9610429-1	1997	1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon.	cyclopiazonic acid	63-66	substance-K receptor	Cavia porcellus	198-210
9610429-1	1997	1 This study aimed to assess the effect of cyclopiazonic acid (CPA), an inhibitor of sarcoplasmic reticulum calcium (Ca) pump, against contractile responses produced by selective tachykinin NK1 and NK2 receptor agonists, [Sar9]substance P (SP) sulfone and [beta Ala8]neurokinin A (NKA) (4-10), respectively, on the circular muscle of guinea-pig colon.	cyclopiazonic acid	63-66	tachykinin precursor 1	Homo sapiens	281-284
9610429-6	1997	CPA slightly and evenly depressed the response to [beta Ala8]NKA (4-10) (18 +/- 7 and 21 +/- 5% inhibition at 1 and 15 min).	cyclopiazonic acid	0-3	tachykinin precursor 1	Homo sapiens	61-64
9610429-10	1997	CPA produced a slight inhibition (15 +/- 9 and 33 +/- 10% at 1 and 15 min, respectively) of the nifedipine-resistant response to [beta Ala8]NKA (4-10), an effect similar to that observed in the absence of nifedipine.	cyclopiazonic acid	0-3	tachykinin precursor 1	Homo sapiens	140-143
9234194-11	1997	The amplitude of the Ca2+ transients recovered spontaneously with an exponential time constant of 59 s. Recovery was accelerated by depolarization-induced elevations in [Ca2+]i and blocked by cyclopiazonic acid (CPA) and thapsigargin, indicating that store refilling is mediated by endoplasmic reticulum Ca(2+)-ATPases.	cyclopiazonic acid	192-210	carbonic anhydrase 2	Rattus norvegicus	21-24
9234194-11	1997	The amplitude of the Ca2+ transients recovered spontaneously with an exponential time constant of 59 s. Recovery was accelerated by depolarization-induced elevations in [Ca2+]i and blocked by cyclopiazonic acid (CPA) and thapsigargin, indicating that store refilling is mediated by endoplasmic reticulum Ca(2+)-ATPases.	cyclopiazonic acid	212-215	carbonic anhydrase 2	Rattus norvegicus	21-24
9234194-11	1997	The amplitude of the Ca2+ transients recovered spontaneously with an exponential time constant of 59 s. Recovery was accelerated by depolarization-induced elevations in [Ca2+]i and blocked by cyclopiazonic acid (CPA) and thapsigargin, indicating that store refilling is mediated by endoplasmic reticulum Ca(2+)-ATPases.	cyclopiazonic acid	212-215	carbonic anhydrase 2	Rattus norvegicus	170-173
8892975-5	1996	An anti-IL-4 antibody almost completely eliminated the anti-apoptotic activity of CPA.	cyclopiazonic acid	82-85	interleukin 4	Homo sapiens	8-12
8931762-0	1996	Increased IL-1, IL-6 and TNF alpha secretion and mRNA levels in WEHI-3 cells exposed to cyclopiazonic acid.	cyclopiazonic acid	88-106	interleukin 1 complex	Mus musculus	10-14
8931762-0	1996	Increased IL-1, IL-6 and TNF alpha secretion and mRNA levels in WEHI-3 cells exposed to cyclopiazonic acid.	cyclopiazonic acid	88-106	interleukin 6	Mus musculus	16-20
8931762-0	1996	Increased IL-1, IL-6 and TNF alpha secretion and mRNA levels in WEHI-3 cells exposed to cyclopiazonic acid.	cyclopiazonic acid	88-106	tumor necrosis factor	Mus musculus	25-34
8931762-3	1996	Without LPS stimulation, only IL-6 was increased by CPA at 5000 ng/ml after 1, 2 and 3 days.	cyclopiazonic acid	52-55	interleukin 6	Mus musculus	30-34
8931762-4	1996	With LPS stimulation, IL-1 beta was elevated in the presence of 500 and 1000 ng/ml of CPA at 1 day and 500, 1000 and 5000 ng/ml at 2 days and 3 days.	cyclopiazonic acid	86-89	interleukin 1 beta	Mus musculus	22-31
8931762-5	1996	TNF alpha was increased by 1000 ng/ml CPA at 12 h and by 500, 1000 and 5000 ng/ml CPA at 1-3 days.	cyclopiazonic acid	38-41	tumor necrosis factor	Mus musculus	0-9
8931762-5	1996	TNF alpha was increased by 1000 ng/ml CPA at 12 h and by 500, 1000 and 5000 ng/ml CPA at 1-3 days.	cyclopiazonic acid	82-85	tumor necrosis factor	Mus musculus	0-9
8931762-6	1996	IL-6 levels were increased in the presence of 100, 500 and 1000 CPA ng/ml at both 12 h and 3 days and in the presence of 100, 500, 1000 and 5000 ng/ml CPA at both 1 day and 2 days.	cyclopiazonic acid	64-67	interleukin 6	Mus musculus	0-4
8931762-6	1996	IL-6 levels were increased in the presence of 100, 500 and 1000 CPA ng/ml at both 12 h and 3 days and in the presence of 100, 500, 1000 and 5000 ng/ml CPA at both 1 day and 2 days.	cyclopiazonic acid	151-154	interleukin 6	Mus musculus	0-4
8892975-1	1996	An ER/SR Ca2+-ATPase inhibitor, cyclopiazonic acid (CPA), was found to suppress apoptotic cell death of IL-3-dependent cell lines, FDC.P2, IC-2, and Ba/F3, upon IL-3 deprivation.	cyclopiazonic acid	32-50	interleukin 3	Homo sapiens	104-108
8892975-1	1996	An ER/SR Ca2+-ATPase inhibitor, cyclopiazonic acid (CPA), was found to suppress apoptotic cell death of IL-3-dependent cell lines, FDC.P2, IC-2, and Ba/F3, upon IL-3 deprivation.	cyclopiazonic acid	32-50	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	139-143
8892975-1	1996	An ER/SR Ca2+-ATPase inhibitor, cyclopiazonic acid (CPA), was found to suppress apoptotic cell death of IL-3-dependent cell lines, FDC.P2, IC-2, and Ba/F3, upon IL-3 deprivation.	cyclopiazonic acid	32-50	interleukin 3	Homo sapiens	161-165
8892975-1	1996	An ER/SR Ca2+-ATPase inhibitor, cyclopiazonic acid (CPA), was found to suppress apoptotic cell death of IL-3-dependent cell lines, FDC.P2, IC-2, and Ba/F3, upon IL-3 deprivation.	cyclopiazonic acid	52-55	interleukin 3	Homo sapiens	104-108
8892975-1	1996	An ER/SR Ca2+-ATPase inhibitor, cyclopiazonic acid (CPA), was found to suppress apoptotic cell death of IL-3-dependent cell lines, FDC.P2, IC-2, and Ba/F3, upon IL-3 deprivation.	cyclopiazonic acid	52-55	dynein cytoplasmic 1 intermediate chain 2	Homo sapiens	139-143
8892975-1	1996	An ER/SR Ca2+-ATPase inhibitor, cyclopiazonic acid (CPA), was found to suppress apoptotic cell death of IL-3-dependent cell lines, FDC.P2, IC-2, and Ba/F3, upon IL-3 deprivation.	cyclopiazonic acid	52-55	interleukin 3	Homo sapiens	161-165
8892975-4	1996	The culture supernatant of CPA-treated cells was able to prolong cell survival of FDC.P2 in the absence of IL-3.	cyclopiazonic acid	27-30	interleukin 3	Homo sapiens	107-111
8691508-4	1996	IL-2 and IL-5 levels were dramatically increased by cyclopiazonic acid at 50-1000 ng/ml, whereas IL-2 was significantly decreased at 10 microgram/ml.	cyclopiazonic acid	52-70	interleukin 2	Mus musculus	0-4
8815877-3	1996	Both thapsigargin (1 microM) and cyclopiazonic acid (1 microM), compounds that deplete all intracellular Ca2+ pools by blocking LTP-dependent Ca2+ uptake into intracellular compartments, blocked the induction, but not maintenance, of LTD by low-frequency stimulation (LFS) (1 Hz/15 min) without affecting baseline synaptic transmission.	cyclopiazonic acid	33-51	carbonic anhydrase 2	Homo sapiens	105-108
8815877-3	1996	Both thapsigargin (1 microM) and cyclopiazonic acid (1 microM), compounds that deplete all intracellular Ca2+ pools by blocking LTP-dependent Ca2+ uptake into intracellular compartments, blocked the induction, but not maintenance, of LTD by low-frequency stimulation (LFS) (1 Hz/15 min) without affecting baseline synaptic transmission.	cyclopiazonic acid	33-51	carbonic anhydrase 2	Homo sapiens	142-145
8772190-5	1996	Consistent with an involvement of calcium, the ER-resident Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid (CPA), which trigger a rapid efflux of Ca2+ from the ER, also potently activated NF-kappaB.	cyclopiazonic acid	99-117	nuclear factor kappa B subunit 1	Homo sapiens	199-208
8772190-5	1996	Consistent with an involvement of calcium, the ER-resident Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid (CPA), which trigger a rapid efflux of Ca2+ from the ER, also potently activated NF-kappaB.	cyclopiazonic acid	119-122	nuclear factor kappa B subunit 1	Homo sapiens	199-208
8772190-7	1996	The Ca2+ chelator BAPTA-AM inhibited ROI formation in response to thapsigargin and CPA treatment, suggesting that the Ca2+ increase preceded ROI formation during NF-kappaB activation.	cyclopiazonic acid	83-86	nuclear factor kappa B subunit 1	Homo sapiens	162-171
8691508-4	1996	IL-2 and IL-5 levels were dramatically increased by cyclopiazonic acid at 50-1000 ng/ml, whereas IL-2 was significantly decreased at 10 microgram/ml.	cyclopiazonic acid	52-70	interleukin 5	Mus musculus	9-13
8691508-12	1996	In total, the EL-4 culture studies indicated that cyclopiazonic acid, ochratoxin A, zearalenone, and alpha-zearalenol could stimulate cytokine production whereas patulin and T-2 toxin were inhibitory.	cyclopiazonic acid	50-68	epilepsy 4	Mus musculus	14-18
8691103-7	1996	Similarly, pretreatment of cells with the [Ca2+]i antagonists thapsigargin or cyclopiazonic acid abolished the GnRH-induced calcium transient, whereas EGTA and nifedipine, a voltage-operated calcium channel (VOCC) antagonist, had no effect.	cyclopiazonic acid	78-96	gonadotropin releasing hormone 1	Rattus norvegicus	111-115
8662717-2	1996	Down-regulation of c-myb mRNA levels by [Ca2+]i-increasing agents (A23187, thapsigargin, cyclopiazonic acid) and erythropoietin was comparatively studied in the erythropoietin-responsive murine erythroleukemia cell line, ELM-I-1.	cyclopiazonic acid	89-107	myeloblastosis oncogene	Mus musculus	19-24
8691103-8	1996	These results suggest that in either immature or mature granulosa cells GnRH mobilises calcium from thapsigargin/cyclopiazonic acid-sensitive [Ca2+]i stores but does not involve the influx of extracellular calcium through VOCCs.	cyclopiazonic acid	113-131	gonadotropin releasing hormone 1	Rattus norvegicus	72-76
8927511-8	1996	CPA exerted its contractile effect even when Ca2+ influx was triggered through the Na+/Ca2+ exchanger and the other Ca2+ entry pathways were blocked.	cyclopiazonic acid	0-3	solute carrier family 8 member A1	Homo sapiens	83-101
8738291-4	1996	The concentrations of U-73122 required for inhibition of CPA- and ionomycin-induced changes with IC50 values 4.06 +/- 0.27 microM and 4.04 +/- 0.44 microM, respectively, is almost 10-times that required for inhibition of the fMLP-induced response (IC50 value 0.62 +/- 0.04 microM).	cyclopiazonic acid	57-60	formyl peptide receptor 1	Homo sapiens	225-229
8882626-17	1996	The ET-1-induced transient increase in [Ca2+]i was significantly reduced by the sarcoplasmic reticulum (SR) Ca(2+)-ATPase inhibitor, cyclopiazonic acid (30 microM); however, the ET-1-induced sustained contraction was not affected by this agent.	cyclopiazonic acid	133-151	endothelin-1	Oryctolagus cuniculus	4-8
8882626-17	1996	The ET-1-induced transient increase in [Ca2+]i was significantly reduced by the sarcoplasmic reticulum (SR) Ca(2+)-ATPase inhibitor, cyclopiazonic acid (30 microM); however, the ET-1-induced sustained contraction was not affected by this agent.	cyclopiazonic acid	133-151	endothelin-1	Oryctolagus cuniculus	178-182
7487872-4	1995	These results suggest that TRH causes the mobilization of Ca2+ from thapsigargin/cyclopiazonic acid-sensitive intracellular Ca2+ stores but not the influx of extracellular Ca2+.	cyclopiazonic acid	81-99	thyrotropin releasing hormone	Homo sapiens	27-30
8701024-4	1996	Tetraethylammonium (TEA, 1-10 mM) and cyclopiazonic acid (CPA, 3-10 microM) produced a concentration-dependent partial inhibition of the relaxant response to CGRP.	cyclopiazonic acid	38-56	calcitonin related polypeptide alpha	Homo sapiens	158-162
8701024-4	1996	Tetraethylammonium (TEA, 1-10 mM) and cyclopiazonic acid (CPA, 3-10 microM) produced a concentration-dependent partial inhibition of the relaxant response to CGRP.	cyclopiazonic acid	58-61	calcitonin related polypeptide alpha	Homo sapiens	158-162
8701024-10	1996	In sucrose gap, brief superfusion with 0.3 microM CGRP produced a TTX (1 microM)- resistant membrane hyperpolarization and relaxation: the hyperpolarization produced by CGRP was inhibited by about 50% by either TEA (10 mM) or CPA (10 microM), while being unaffected by glibenclamide (3 microM).	cyclopiazonic acid	226-229	calcitonin related polypeptide alpha	Homo sapiens	50-54
8701024-10	1996	In sucrose gap, brief superfusion with 0.3 microM CGRP produced a TTX (1 microM)- resistant membrane hyperpolarization and relaxation: the hyperpolarization produced by CGRP was inhibited by about 50% by either TEA (10 mM) or CPA (10 microM), while being unaffected by glibenclamide (3 microM).	cyclopiazonic acid	226-229	calcitonin related polypeptide alpha	Homo sapiens	169-173
8750956-3	1995	Cyclopiazonic acid, a microsomal Ca2+ ATPase inhibitor, reversibly depleted intracellular Ca2+ stores in these cells, but did not recruit detectable Ca2+ influx, suggesting that these cells lack substantial capacitative Ca2+ entry.	cyclopiazonic acid	0-18	carbonic anhydrase 2	Mus musculus	33-44
8773410-6	1996	Cyclopiazonic acid (30 microM), an inhibitor of the sarcoplasmic reticulum Ca2+ pump, caused transient contractions in the dog saphenous vein only in the presence of extracellular Ca2+.	cyclopiazonic acid	0-18	carbonic anhydrase 2	Canis lupus familiaris	75-78
8773410-6	1996	Cyclopiazonic acid (30 microM), an inhibitor of the sarcoplasmic reticulum Ca2+ pump, caused transient contractions in the dog saphenous vein only in the presence of extracellular Ca2+.	cyclopiazonic acid	0-18	carbonic anhydrase 2	Canis lupus familiaris	180-183
8925197-8	1996	However, the cells responding to PAF as the cells treated with fMLP or cyclopiazonic acid released almost the entire Ca2+ from intracellular stores after challenge.	cyclopiazonic acid	71-89	PCNA clamp associated factor	Homo sapiens	33-36
8821550-2	1996	By use of the whole-cell configuration of the patch-clamp technique, membrane currents induced by cyclopiazonic acid (CPA; an inhibitor of the sarcoplasmic reticulum (SR) calcium-ATPase) were investigated in single smooth muscle cells freshly dispersed from the mouse anococcygeus.	cyclopiazonic acid	98-116	carboxypeptidase A1, pancreatic	Mus musculus	118-121
8647884-15	1996	Moreover, treatment of cells with two inhibitors of the ER-resident Ca(2+) -dependent ATPase, thapsigargin and cyclopiazonic acid, which causes a rapid release of Ca2+ from the ER, strongly activated NF-kappaB.	cyclopiazonic acid	111-129	nuclear factor kappa B subunit 1	Homo sapiens	200-209
7594504-7	1995	Inhibition of GPLC activity and IP3 production with U73122 and cyclopiazonic acid blocked the ability of fibronectin to increase CD16 expression and E anti-Fc gamma RIII rosetting.	cyclopiazonic acid	63-81	fibronectin 1	Homo sapiens	105-116
7594504-7	1995	Inhibition of GPLC activity and IP3 production with U73122 and cyclopiazonic acid blocked the ability of fibronectin to increase CD16 expression and E anti-Fc gamma RIII rosetting.	cyclopiazonic acid	63-81	Fc gamma receptor IIIa	Homo sapiens	129-133
7594504-7	1995	Inhibition of GPLC activity and IP3 production with U73122 and cyclopiazonic acid blocked the ability of fibronectin to increase CD16 expression and E anti-Fc gamma RIII rosetting.	cyclopiazonic acid	63-81	Fc gamma receptor IIIa	Homo sapiens	156-169
8519694-9	1995	Tg and CPA also inhibit the expression of mRNA and protein for specific epidermal spinous cell markers, keratins 1 (K1) and 10 (K10), prevent the redistribution of E-cadherin from a diffuse membranous pattern to concentration at cell-cell junctions, and inhibit the activation of a reporter gene regulated by a K1 enhancer element shown previously to be Ca2+ sensitive.	cyclopiazonic acid	7-10	keratin 1	Mus musculus	116-118
8519694-9	1995	Tg and CPA also inhibit the expression of mRNA and protein for specific epidermal spinous cell markers, keratins 1 (K1) and 10 (K10), prevent the redistribution of E-cadherin from a diffuse membranous pattern to concentration at cell-cell junctions, and inhibit the activation of a reporter gene regulated by a K1 enhancer element shown previously to be Ca2+ sensitive.	cyclopiazonic acid	7-10	cadherin 1	Mus musculus	164-174
8519694-9	1995	Tg and CPA also inhibit the expression of mRNA and protein for specific epidermal spinous cell markers, keratins 1 (K1) and 10 (K10), prevent the redistribution of E-cadherin from a diffuse membranous pattern to concentration at cell-cell junctions, and inhibit the activation of a reporter gene regulated by a K1 enhancer element shown previously to be Ca2+ sensitive.	cyclopiazonic acid	7-10	keratin 1	Mus musculus	128-130
8519694-11	1995	In contrast, Tg and CPA enhance the expression of profilaggrin and loricrin mRNA and protein, markers of granular cell differentiation.	cyclopiazonic acid	20-23	filaggrin	Mus musculus	50-62
8519694-11	1995	In contrast, Tg and CPA enhance the expression of profilaggrin and loricrin mRNA and protein, markers of granular cell differentiation.	cyclopiazonic acid	20-23	loricrin	Mus musculus	67-75
7520693-1	1994	Thapsigargin (TG), 2,5-t-butylhydroquinone (tBHQ) and cyclopiazonic acid (CPA) all inhibit the initial Ca(2+)-response to thyrotropin-releasing hormone (TRH) by depleting intracellular Ca2+ pools sensitive to inositol 1,4,5-trisphosphate (IP3).	cyclopiazonic acid	54-72	thyrotropin releasing hormone	Rattus norvegicus	122-151
7540612-5	1995	Levels of IL-1-induced iNOS protein were reduced by A23187, thapsigargin, and cyclopiazonic acid.	cyclopiazonic acid	78-96	nitric oxide synthase 2	Homo sapiens	23-27
7602106-0	1995	Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages.	cyclopiazonic acid	17-35	interleukin 6	Mus musculus	77-81
7602106-0	1995	Thapsigargin and cyclopiazonic acid initiate rapid and dramatic increases of IL-6 mRNA expression and IL-6 secretion in murine peritoneal macrophages.	cyclopiazonic acid	17-35	interleukin 6	Mus musculus	102-106
7602106-3	1995	The activity of these inhibitors was linked to an important biologic response, because both cyclopiazonic acid and thapsigargin induced rapid and dramatic increases in IL-6 mRNA expression and secretion.	cyclopiazonic acid	92-110	interleukin 6	Mus musculus	168-172
7602106-5	1995	The increased mRNA expression was coupled to translation and secretion of this monokine since cyclopiazonic acid and thapsigargin induced significant increases in IL-6 secretion as early as 2 h, and up to approximately 70-fold increases by 20 h, when compared with control cultures.	cyclopiazonic acid	94-112	interleukin 6	Mus musculus	163-167
7602106-6	1995	Taken together, these results demonstrate that both cyclopiazonic acid and thapsigargin generate potent intracellular signals that initiate rapid and dramatic production of IL-6.	cyclopiazonic acid	52-70	interleukin 6	Mus musculus	173-177
7602106-7	1995	Both thapsigargin and cyclopiazonic acid increased IL-6 mRNA expression at 15 min in the absence of Ca2+ influx from the extracellular medium.	cyclopiazonic acid	22-40	interleukin 6	Mus musculus	51-55
7540139-2	1995	IO, but not INS, failed to be reproduced in Ca(2+)-free solution and was markedly reduced by prior exposure to caffeine under Ca(2+)-free conditions or by addition to normal solution of cyclopiazonic acid (CPA), a Ca2+ ATPase inhibitor.	cyclopiazonic acid	186-204	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	214-225
7698197-5	1994	Furthermore, application of cyclopiazonic acid modified the twitch, the caffeine responses and decreased the amount of Ca2+ taken up by the sarcoplasmic reticulum in saponin-skinned fibres.	cyclopiazonic acid	28-46	carbonic anhydrase 2	Mustela putorius furo	119-122
7520693-1	1994	Thapsigargin (TG), 2,5-t-butylhydroquinone (tBHQ) and cyclopiazonic acid (CPA) all inhibit the initial Ca(2+)-response to thyrotropin-releasing hormone (TRH) by depleting intracellular Ca2+ pools sensitive to inositol 1,4,5-trisphosphate (IP3).	cyclopiazonic acid	54-72	thyrotropin releasing hormone	Rattus norvegicus	153-156
7520693-1	1994	Thapsigargin (TG), 2,5-t-butylhydroquinone (tBHQ) and cyclopiazonic acid (CPA) all inhibit the initial Ca(2+)-response to thyrotropin-releasing hormone (TRH) by depleting intracellular Ca2+ pools sensitive to inositol 1,4,5-trisphosphate (IP3).	cyclopiazonic acid	74-77	thyrotropin releasing hormone	Rattus norvegicus	122-151
7520693-1	1994	Thapsigargin (TG), 2,5-t-butylhydroquinone (tBHQ) and cyclopiazonic acid (CPA) all inhibit the initial Ca(2+)-response to thyrotropin-releasing hormone (TRH) by depleting intracellular Ca2+ pools sensitive to inositol 1,4,5-trisphosphate (IP3).	cyclopiazonic acid	74-77	thyrotropin releasing hormone	Rattus norvegicus	153-156
7520693-2	1994	Treatment of GH3 pituitary cells for 30 min with 5 nM TG, 500 nM tBHQ or 50 nM CPA completely eliminated the TRH-induced spike in intracellular free Ca2+ ([Ca2+]i).	cyclopiazonic acid	79-82	thyrotropin releasing hormone	Rattus norvegicus	109-112
8132611-0	1994	Early transient suppression of c-myb mRNA levels and induction of differentiation in Friend erythroleukemia cells by the [Ca2+]i-increasing agents cyclopiazonic acid and thapsigargin.	cyclopiazonic acid	147-165	MYB proto-oncogene, transcription factor	Homo sapiens	31-36
8006954-2	1994	Depletion of [Ca2+]i stores by the application of thapsigargin, ionomycin or cyclopiazonic acid induced a depolarization which was (i) dependent upon BAPTA-loading, (ii) dependent upon extracellular Ca2+, (iii) independent of extracellular Na+ and (iv) abolished by 5 mM extracellular Ni2+.	cyclopiazonic acid	77-95	carbonic anhydrase 2	Homo sapiens	14-17
7517325-6	1994	4</protein-id> The calmodulin inhibitors calmidazolium (3-10 microM) and W-7 (100 microM) also abolished CPA-induced relaxation.	cyclopiazonic acid	105-108	calmodulin 1	Rattus norvegicus	19-29
7517325-8	1994	6 The inhibitors of NO synthesis and actions, the calmodulin inhibitor and removal of the endothelium abolished the CPA-stimulated increase in the levels of cyclic GMP.	cyclopiazonic acid	116-119	calmodulin 1	Rattus norvegicus	50-60
8004399-12	1994	Like NDGA, the sarcoplasmic reticulum Ca(2+)-ATPase inhibitors cyclopiazonic acid and thapsigargin inhibited contractions to ET-1, but not carbachol or KCl.	cyclopiazonic acid	63-81	endothelin 1	Rattus norvegicus	125-129
8004399-13	1994	However, cyclopiazonic acid, but not NDGA, also (a) induced transient contractions in rat trachea, (b) potentiated contractions induced by KCl, and (c) potentiated the extracellular Ca(2+)-dependent phase of ET-1-induced contractions, indicating that NDGA did not inhibit ET-1-induced contractions through Ca(2+)-ATPase inhibition and depletion of sarcoplasmic reticular Ca2+.	cyclopiazonic acid	9-27	endothelin 1	Rattus norvegicus	208-212
8004399-13	1994	However, cyclopiazonic acid, but not NDGA, also (a) induced transient contractions in rat trachea, (b) potentiated contractions induced by KCl, and (c) potentiated the extracellular Ca(2+)-dependent phase of ET-1-induced contractions, indicating that NDGA did not inhibit ET-1-induced contractions through Ca(2+)-ATPase inhibition and depletion of sarcoplasmic reticular Ca2+.	cyclopiazonic acid	9-27	endothelin 1	Rattus norvegicus	272-276
8132611-6	1994	Studies on the differentiation status of F4-6 cells following cyclopiazonic acid or thapsigargin exposure demonstrated a marked increase in beta-globin mRNA synthesis at 60h and in hemoglobin production at 96 h. These results provide further evidence that a rise in the cytosolic Ca2+ concentration is capable, in Friend erythroleukemia cells, of inducing an early transient suppression of c-myb mRNA levels, which is followed by terminal erythroid differentiation.	cyclopiazonic acid	62-80	MYB proto-oncogene, transcription factor	Homo sapiens	390-395
7508754-6	1994	Finally, in contrast to the findings with TG and BHQ, CPA inhibited bombesin-stimulated enzyme secretion over a range of concentrations that was at least 10-fold lower than the range of concentrations over which CPA potentiated VIP-stimulated enzyme secretion.	cyclopiazonic acid	212-215	vasoactive intestinal peptide	Rattus norvegicus	228-231
8006954-2	1994	Depletion of [Ca2+]i stores by the application of thapsigargin, ionomycin or cyclopiazonic acid induced a depolarization which was (i) dependent upon BAPTA-loading, (ii) dependent upon extracellular Ca2+, (iii) independent of extracellular Na+ and (iv) abolished by 5 mM extracellular Ni2+.	cyclopiazonic acid	77-95	carbonic anhydrase 2	Homo sapiens	199-202
34899622-5	2021	CPA killed the second-stage juveniles of M. incognita, M. hapla, and M. arearia with EC50-3 days 4.50, 18.82, and 60.51 mug mL-1, respectively.	cyclopiazonic acid	0-3	L1 cell adhesion molecule	Mus musculus	124-128
1834695-8	1991	Using these procedures, we also examined the effect of cyclopiazonic acid (CPA) which was reported to be a specific inhibitor of Ca(2+)-ATPase of SR. Ca(2+)-ATPase activity of SR in skinned fibres was inhibited completely by 10 microM CPA and held to one-half by about 0.2 microM.	cyclopiazonic acid	55-73	dynein axonemal heavy chain 8	Homo sapiens	136-142
1834695-8	1991	Using these procedures, we also examined the effect of cyclopiazonic acid (CPA) which was reported to be a specific inhibitor of Ca(2+)-ATPase of SR. Ca(2+)-ATPase activity of SR in skinned fibres was inhibited completely by 10 microM CPA and held to one-half by about 0.2 microM.	cyclopiazonic acid	55-73	dynein axonemal heavy chain 8	Homo sapiens	157-163
1834695-8	1991	Using these procedures, we also examined the effect of cyclopiazonic acid (CPA) which was reported to be a specific inhibitor of Ca(2+)-ATPase of SR. Ca(2+)-ATPase activity of SR in skinned fibres was inhibited completely by 10 microM CPA and held to one-half by about 0.2 microM.	cyclopiazonic acid	75-78	dynein axonemal heavy chain 8	Homo sapiens	136-142
1834695-8	1991	Using these procedures, we also examined the effect of cyclopiazonic acid (CPA) which was reported to be a specific inhibitor of Ca(2+)-ATPase of SR. Ca(2+)-ATPase activity of SR in skinned fibres was inhibited completely by 10 microM CPA and held to one-half by about 0.2 microM.	cyclopiazonic acid	75-78	dynein axonemal heavy chain 8	Homo sapiens	157-163
1834695-11	1991	CPA at 3 microM inhibited almost completely the Ca(2+)-ATPase activity of SR, while it had no effect on either actomyosin-type ATPase or isometric tension of myofibrils.	cyclopiazonic acid	0-3	dynein axonemal heavy chain 8	Homo sapiens	55-61
1609418-9	1992	Previously, it was shown that cyclopiazonic acid was twice as effective as cyclopiazonic acid imine at preventing increases in thiobarbituric acid positive substance in cultured renal cells, LLC-PK1.	cyclopiazonic acid	30-48	pyruvate kinase L/R	Rattus norvegicus	195-198
34322792-4	2022	Therefore, in this study, we aimed to examine the ability of BBP to remove other 12 mycotoxins (including aflatoxin B1, aflatoxin M1, citrinin, dihydrocitrinone, cyclopiazonic acid, deoxynivalenol, ochratoxin A, patulin, sterigmatocystin, zearalanone, alpha-zearalanol, and beta-zearalanol) from different buffers (pH 3.0, 5.0, and 7.0).	cyclopiazonic acid	162-180	TM2 domain containing 1	Homo sapiens	61-64
34899622-6	2021	CPA also significantly inhibited egg hatch of M. incognita and M. hapla after a total of 28 days of treatment with the concentrations > 25 mug mL-1.	cyclopiazonic acid	0-3	L1 cell adhesion molecule	Mus musculus	143-147
34899622-8	2021	The highest CPA production (381.48 mug mL-1) was obtained from the optimized medium, exhibiting an increase of 7.88 times when compared with that from potato dextrose broth culture.	cyclopiazonic acid	12-15	L1 cell adhesion molecule	Mus musculus	39-43
34252492-0	2021	Effects of growth hormone-releasing hormone analog MR-409 on insulin-secreting cells under cyclopiazonic acid-induced endoplasmic reticulum stress.	cyclopiazonic acid	91-109	growth hormone releasing hormone	Rattus norvegicus	11-43
34032641-6	2021	Glucose-stimulated membrane potential depolarization and Ca2+ influx was inhibited in mouse islets expressing TALK-1 Leu114Pro (area under the Ca2+ curve [AUC] at 20mM glucose: Leu114Pro 60.1 vs. WT 89.1; P=0.030) with less endoplasmic reticulum Ca2+ storage (cyclopiazonic acid-induced release AUC: Leu114Pro 17.5 vs. WT 46.8; P=0.008).	cyclopiazonic acid	260-278	potassium channel, subfamily K, member 16	Mus musculus	110-116
35508807-8	2022	CPA also promoted reactive oxygen species production and phosphorylation of ERK1/2 and p38.	cyclopiazonic acid	0-3	adapter molecule crk	Gallus gallus	87-90
35508807-9	2022	In addition, CPA-triggered HETs formation was reduced by NADPH oxidase, ERK1/2, and p38 signaling pathway and glycolysis inhibitors, indicating that CPA-induced HETs were related to the production of ROS dependent on NADPH oxidase, ERK1/2, and p38 signaling pathways, as well as glycolysis.	cyclopiazonic acid	13-16	adapter molecule crk	Gallus gallus	84-87
35508807-9	2022	In addition, CPA-triggered HETs formation was reduced by NADPH oxidase, ERK1/2, and p38 signaling pathway and glycolysis inhibitors, indicating that CPA-induced HETs were related to the production of ROS dependent on NADPH oxidase, ERK1/2, and p38 signaling pathways, as well as glycolysis.	cyclopiazonic acid	13-16	adapter molecule crk	Gallus gallus	244-247
35508807-9	2022	In addition, CPA-triggered HETs formation was reduced by NADPH oxidase, ERK1/2, and p38 signaling pathway and glycolysis inhibitors, indicating that CPA-induced HETs were related to the production of ROS dependent on NADPH oxidase, ERK1/2, and p38 signaling pathways, as well as glycolysis.	cyclopiazonic acid	149-152	adapter molecule crk	Gallus gallus	84-87
35508807-9	2022	In addition, CPA-triggered HETs formation was reduced by NADPH oxidase, ERK1/2, and p38 signaling pathway and glycolysis inhibitors, indicating that CPA-induced HETs were related to the production of ROS dependent on NADPH oxidase, ERK1/2, and p38 signaling pathways, as well as glycolysis.	cyclopiazonic acid	149-152	adapter molecule crk	Gallus gallus	244-247
35081665-15	2022	Platelet-derived growth factor receptor alpha (PDGFRalpha)-immunoreactive SICs were distributed just beneath the basal side of the BM and developed synchronous Ca2+ oscillations (SCOs) and electrical slow waves, which were suppressed by 3 muM nifedipine and abolished by 10 muM CPA.	cyclopiazonic acid	278-281	platelet-derived growth factor receptor alpha	Cavia porcellus	0-45
33400354-0	2021	Cyclopiazonic acid induced p53-dependent apoptosis in the testis of mice: Another male related risk factor of infertility.	cyclopiazonic acid	0-18	transformation related protein 53, pseudogene	Mus musculus	27-30
34045974-7	2021	SERCA was inhibited with cyclopiazonic acid (CPA; 1-10 muM).	cyclopiazonic acid	25-43	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	0-5
34045974-7	2021	SERCA was inhibited with cyclopiazonic acid (CPA; 1-10 muM).	cyclopiazonic acid	45-48	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	0-5
34045974-8	2021	SERCA inhibition (1, 5, and 10 muM of CPA) resulted in dose-dependent slowing of SR Ca2+ reuptake, with the time constant (tau) increasing from 70.8 +- 3.5 ms at baseline to 85.5 +- 6.6, 129.9 +- 20.7, and 271.3 +- 37.6 ms, respectively (p < 0.05 vs. baseline for all doses).	cyclopiazonic acid	38-41	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	0-5
34045974-8	2021	SERCA inhibition (1, 5, and 10 muM of CPA) resulted in dose-dependent slowing of SR Ca2+ reuptake, with the time constant (tau) increasing from 70.8 +- 3.5 ms at baseline to 85.5 +- 6.6, 129.9 +- 20.7, and 271.3 +- 37.6 ms, respectively (p < 0.05 vs. baseline for all doses).	cyclopiazonic acid	38-41	microtubule associated protein tau	Homo sapiens	123-126
33400354-9	2021	Significant up-regulation (p < .05) in the expression of P53 and Caspase III genes and down-regulation of Bcl-2 gene were found in the CPA-received groups.	cyclopiazonic acid	135-138	transformation related protein 53, pseudogene	Mus musculus	57-60
33400354-9	2021	Significant up-regulation (p < .05) in the expression of P53 and Caspase III genes and down-regulation of Bcl-2 gene were found in the CPA-received groups.	cyclopiazonic acid	135-138	B cell leukemia/lymphoma 2	Mus musculus	106-111
33427050-6	2021	These effects were blocked by pretreatment with cyclopiazonic acid (CPA), a SERCA inhibitor, and by knockdown of SERCA2 with siRNA, suggesting that SERCA2 plays a critical role in progesterone induction of VSMC relaxation.	cyclopiazonic acid	48-66	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	148-154
33427050-6	2021	These effects were blocked by pretreatment with cyclopiazonic acid (CPA), a SERCA inhibitor, and by knockdown of SERCA2 with siRNA, suggesting that SERCA2 plays a critical role in progesterone induction of VSMC relaxation.	cyclopiazonic acid	68-71	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	76-81
33427050-6	2021	These effects were blocked by pretreatment with cyclopiazonic acid (CPA), a SERCA inhibitor, and by knockdown of SERCA2 with siRNA, suggesting that SERCA2 plays a critical role in progesterone induction of VSMC relaxation.	cyclopiazonic acid	68-71	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	148-154
32949582-7	2020	KEY RESULTS: SOC entry stimulated by emptying sarcoplasmic reticulum (SR) Ca2+ store with cyclopiazonic acid (CPA) was decreased and associated to decreased STIM-1 and Orai1 protein expression in OZR CA.	cyclopiazonic acid	90-108	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	168-173
33531589-11	2021	They implicate possible local tubule-sarcoplasmic triadic domains containing reduced [Ca2+]TSR in the observed upregulation of Nav1.4 function following CPA-induced SR Ca2+ depletion.	cyclopiazonic acid	153-156	sodium channel, voltage-gated, type IV, alpha	Mus musculus	127-133
32949582-7	2020	KEY RESULTS: SOC entry stimulated by emptying sarcoplasmic reticulum (SR) Ca2+ store with cyclopiazonic acid (CPA) was decreased and associated to decreased STIM-1 and Orai1 protein expression in OZR CA.	cyclopiazonic acid	110-113	stromal interaction molecule 1	Rattus norvegicus	157-163
32949582-7	2020	KEY RESULTS: SOC entry stimulated by emptying sarcoplasmic reticulum (SR) Ca2+ store with cyclopiazonic acid (CPA) was decreased and associated to decreased STIM-1 and Orai1 protein expression in OZR CA.	cyclopiazonic acid	110-113	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	168-173
32342308-1	2020	Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor antagonist neuroleptic chlorpromazine significantly inhibits glutoxim- and molixan-induced Ca2+ responses and Ca2+ responses induced by endoplasmic reticulum Sa2+-ATPase inhibitors thapsigargin and cyclopiazonic acid in rat peritoneal macrophages.	cyclopiazonic acid	286-304	sigma non-opioid intracellular receptor 1	Rattus norvegicus	71-87
31982470-11	2020	Finally, the protein expression of HCN4 in HEK293 cells was markedly downregulated by CPA.	cyclopiazonic acid	86-89	hyperpolarization activated cyclic nucleotide gated potassium channel 4	Homo sapiens	35-39
32559219-6	2020	Inhibition of ryanodine-sensitive Ca2+ stores by ryanodine or depletion by the SERCA pump inhibitor cyclopiazonic acid caused a substantial attenuation in the sIAHP activity-dependent potentiation in both rat and mouse CA1 pyramidal neurons.	cyclopiazonic acid	100-118	carbonic anhydrase 1	Mus musculus	219-222
32296344-12	2020	Additionally, in endothelial cell (EC)-denuded aortic segments, the SERCA-inhibitor cyclopiazonic acid (CPA) caused markedly larger contractions in SERCA2b/b mice, while the increases of cytosolic Ca2+ were similar in both strains.	cyclopiazonic acid	84-102	ATPase, Ca++ transporting, ubiquitous	Mus musculus	68-73
32296344-12	2020	Additionally, in endothelial cell (EC)-denuded aortic segments, the SERCA-inhibitor cyclopiazonic acid (CPA) caused markedly larger contractions in SERCA2b/b mice, while the increases of cytosolic Ca2+ were similar in both strains.	cyclopiazonic acid	84-102	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	148-157
32296344-12	2020	Additionally, in endothelial cell (EC)-denuded aortic segments, the SERCA-inhibitor cyclopiazonic acid (CPA) caused markedly larger contractions in SERCA2b/b mice, while the increases of cytosolic Ca2+ were similar in both strains.	cyclopiazonic acid	104-107	ATPase, Ca++ transporting, ubiquitous	Mus musculus	68-73
32296344-12	2020	Additionally, in endothelial cell (EC)-denuded aortic segments, the SERCA-inhibitor cyclopiazonic acid (CPA) caused markedly larger contractions in SERCA2b/b mice, while the increases of cytosolic Ca2+ were similar in both strains.	cyclopiazonic acid	104-107	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	148-157
30840346-12	2019	The increase in Cav1 by introduction of Cav1 scaffolding domain enhancing peptide promoted the 1-oleoyl-2-acetyl-glycerol-induced ROCE in hypertensive aortic smooth muscle cells but did not enhance the cyclopiazonic acid-induced SOCE.	cyclopiazonic acid	202-220	caveolin 1	Rattus norvegicus	16-20
31768847-1	2019	Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist-tricyclic antidepressant amitriptyline-significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages.	cyclopiazonic acid	249-267	sigma non-opioid intracellular receptor 1	Rattus norvegicus	71-87
30840346-12	2019	The increase in Cav1 by introduction of Cav1 scaffolding domain enhancing peptide promoted the 1-oleoyl-2-acetyl-glycerol-induced ROCE in hypertensive aortic smooth muscle cells but did not enhance the cyclopiazonic acid-induced SOCE.	cyclopiazonic acid	202-220	caveolin 1	Rattus norvegicus	40-44
30446391-6	2019	Furthermore, CPA resulted in an accelerated degeneration of motor neurons expressing human superoxide dismutase 1 (hSOD1) carrying the ALS-causing G93A mutation, compared to motor neurons expressing wild-type hSOD1.	cyclopiazonic acid	13-16	superoxide dismutase 1	Homo sapiens	91-113
30307768-0	2019	Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn2.	cyclopiazonic acid	33-51	transmembrane protein 165	Homo sapiens	85-92
30307768-7	2019	In contrast, our results demonstrate the involvement of cyclopiazonic acid- and thapsigargin (Tg)-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn2+.	cyclopiazonic acid	56-74	transmembrane protein 165	Homo sapiens	131-138
30446391-6	2019	Furthermore, CPA resulted in an accelerated degeneration of motor neurons expressing human superoxide dismutase 1 (hSOD1) carrying the ALS-causing G93A mutation, compared to motor neurons expressing wild-type hSOD1.	cyclopiazonic acid	13-16	superoxide dismutase 1	Homo sapiens	115-120
30446391-6	2019	Furthermore, CPA resulted in an accelerated degeneration of motor neurons expressing human superoxide dismutase 1 (hSOD1) carrying the ALS-causing G93A mutation, compared to motor neurons expressing wild-type hSOD1.	cyclopiazonic acid	13-16	superoxide dismutase 1	Homo sapiens	209-214
29229760-9	2018	We also showed that SMA1 and SMA2 had close sensitivities to cyclopiazonic acid but different sensitivities to thapsigargin, two specific inhibitors of SERCA pumps.	cyclopiazonic acid	61-79	Sma1p	Saccharomyces cerevisiae S288C	20-24
29897864-8	2018	Application of the sarco/endoplasmic Ca2+ ATPase inhibitor cyclopiazonic acid blocked the generation of SMOCs and also increased neural excitability.	cyclopiazonic acid	59-77	carbonic anhydrase 2	Homo sapiens	37-48
29668377-5	2018	Consistent with this hypothesis, the IR-induced [Ca2+] response was prolonged and eventually blocked by inhibition of ER Ca2+-ATPase with cyclopiazonic acid, and was also inhibited by a high concentration of ryanodine and by inhibitors of inositol (1,4,5)-trisphosphate (IP3)-mediated Ca2+ release (xestospongin C and 2-aminoethoxydiphenyl borate).	cyclopiazonic acid	138-156	carbonic anhydrase 2	Mus musculus	49-52
29668377-5	2018	Consistent with this hypothesis, the IR-induced [Ca2+] response was prolonged and eventually blocked by inhibition of ER Ca2+-ATPase with cyclopiazonic acid, and was also inhibited by a high concentration of ryanodine and by inhibitors of inositol (1,4,5)-trisphosphate (IP3)-mediated Ca2+ release (xestospongin C and 2-aminoethoxydiphenyl borate).	cyclopiazonic acid	138-156	carbonic anhydrase 2	Mus musculus	121-124
29668377-5	2018	Consistent with this hypothesis, the IR-induced [Ca2+] response was prolonged and eventually blocked by inhibition of ER Ca2+-ATPase with cyclopiazonic acid, and was also inhibited by a high concentration of ryanodine and by inhibitors of inositol (1,4,5)-trisphosphate (IP3)-mediated Ca2+ release (xestospongin C and 2-aminoethoxydiphenyl borate).	cyclopiazonic acid	138-156	carbonic anhydrase 2	Mus musculus	121-124
30008101-1	2018	Using Fura-2AM microfluorimetry, we have shown for the first time that preincubation of macrophages with sigma-1 receptor antagonist haloperidol leads to a significant inhibition of the store-dependent Ca2+ entry induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin or cyclopiazonic acid in rat peritoneal macrophages.	cyclopiazonic acid	275-293	sigma non-opioid intracellular receptor 1	Rattus norvegicus	105-121
29273673-6	2018	This protection was abolished by cotreatment with the SERCA inhibitor cyclopiazonic acid.	cyclopiazonic acid	70-88	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	54-59
29696338-5	2018	The A. flavus ecm33 null mutant, compared with the wild type and the complemented strain, produced predominantly aflatoxin B2 but accumulated comparable amounts of cyclopiazonic acid.	cyclopiazonic acid	164-182	Ecm33p	Saccharomyces cerevisiae S288C	14-19
29599149-5	2018	The SERCA inhibitor cyclopiazonic acid (CPA) normalises both the initial reduction and the later increase in cytosolic Ca2+ CPA protects the cells against alpha-synuclein-aggregate stress and improves viability in cell models and in Caenorhabditis elegans in vivo Proximity ligation assays also reveal an increased interaction between alpha-synuclein aggregates and SERCA in human brains affected by dementia with Lewy bodies.	cyclopiazonic acid	20-38	synuclein alpha	Homo sapiens	155-170
29599149-5	2018	The SERCA inhibitor cyclopiazonic acid (CPA) normalises both the initial reduction and the later increase in cytosolic Ca2+ CPA protects the cells against alpha-synuclein-aggregate stress and improves viability in cell models and in Caenorhabditis elegans in vivo Proximity ligation assays also reveal an increased interaction between alpha-synuclein aggregates and SERCA in human brains affected by dementia with Lewy bodies.	cyclopiazonic acid	20-38	synuclein alpha	Homo sapiens	335-350
29599149-5	2018	The SERCA inhibitor cyclopiazonic acid (CPA) normalises both the initial reduction and the later increase in cytosolic Ca2+ CPA protects the cells against alpha-synuclein-aggregate stress and improves viability in cell models and in Caenorhabditis elegans in vivo Proximity ligation assays also reveal an increased interaction between alpha-synuclein aggregates and SERCA in human brains affected by dementia with Lewy bodies.	cyclopiazonic acid	40-43	synuclein alpha	Homo sapiens	155-170
29599149-5	2018	The SERCA inhibitor cyclopiazonic acid (CPA) normalises both the initial reduction and the later increase in cytosolic Ca2+ CPA protects the cells against alpha-synuclein-aggregate stress and improves viability in cell models and in Caenorhabditis elegans in vivo Proximity ligation assays also reveal an increased interaction between alpha-synuclein aggregates and SERCA in human brains affected by dementia with Lewy bodies.	cyclopiazonic acid	40-43	synuclein alpha	Homo sapiens	335-350
29599149-5	2018	The SERCA inhibitor cyclopiazonic acid (CPA) normalises both the initial reduction and the later increase in cytosolic Ca2+ CPA protects the cells against alpha-synuclein-aggregate stress and improves viability in cell models and in Caenorhabditis elegans in vivo Proximity ligation assays also reveal an increased interaction between alpha-synuclein aggregates and SERCA in human brains affected by dementia with Lewy bodies.	cyclopiazonic acid	124-127	synuclein alpha	Homo sapiens	155-170
29365044-6	2018	A similar FRET increase in response to CPA was also detected in oocytes co-expressing mVenus-STIM1 and mTurquoise2-STIM1, which is consistent with STIM1 forming punctae after store depletion.	cyclopiazonic acid	39-42	stromal interaction molecule 1	Sus scrofa	93-98
29365044-6	2018	A similar FRET increase in response to CPA was also detected in oocytes co-expressing mVenus-STIM1 and mTurquoise2-STIM1, which is consistent with STIM1 forming punctae after store depletion.	cyclopiazonic acid	39-42	stromal interaction molecule 1	Sus scrofa	115-120
29365044-6	2018	A similar FRET increase in response to CPA was also detected in oocytes co-expressing mVenus-STIM1 and mTurquoise2-STIM1, which is consistent with STIM1 forming punctae after store depletion.	cyclopiazonic acid	39-42	stromal interaction molecule 1	Sus scrofa	115-120
29229760-9	2018	We also showed that SMA1 and SMA2 had close sensitivities to cyclopiazonic acid but different sensitivities to thapsigargin, two specific inhibitors of SERCA pumps.	cyclopiazonic acid	61-79	Sma2p	Saccharomyces cerevisiae S288C	29-33
27245842-14	2016	We also observed thapsigargin (TG)- or CPA-induced puncta formation of STIM1 and Orai1.	cyclopiazonic acid	39-42	stromal interaction molecule 1	Mus musculus	71-76
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	cyclopiazonic acid	208-226	ryanodine receptor 1	Homo sapiens	56-59
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	cyclopiazonic acid	208-226	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	cyclopiazonic acid	228-231	ryanodine receptor 1	Homo sapiens	56-59
28570539-7	2017	With this method, a decrease in ER calcium is seen with RyR activation with 4-chloro-m-cresol (4-cmc), the indirect activation of IP3R with adenosine triphosphate (ATP), and inhibition of the SERCA pump with cyclopiazonic acid (CPA).	cyclopiazonic acid	228-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	130-134
28230659-8	2017	Activation of alpha2A adrenoceptors markedly prolongs the period of glucose-induced Ca decrease, an effect counteracted by cyclopiazonic acid.	cyclopiazonic acid	123-141	adrenergic receptor, alpha 2a	Mus musculus	14-21
27311393-8	2016	Introduction of Cav-1 scaffolding domain peptide to mimic Cav-1 upregulation caused significant increase in CPA- and OAG-induced Ca(2+) entry in PASMCs of control, CH and MCT-treated groups.	cyclopiazonic acid	108-111	caveolin 1	Rattus norvegicus	16-21
27311393-8	2016	Introduction of Cav-1 scaffolding domain peptide to mimic Cav-1 upregulation caused significant increase in CPA- and OAG-induced Ca(2+) entry in PASMCs of control, CH and MCT-treated groups.	cyclopiazonic acid	108-111	caveolin 1	Rattus norvegicus	58-63
27538371-9	2016	In addition, DCs treated with a SERCA2-specific inhibitor (cyclopiazonic acid) had significantly increased migratory capacities as mDCs regardless of SERCA2 expression.	cyclopiazonic acid	59-77	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	32-38
27538371-9	2016	In addition, DCs treated with a SERCA2-specific inhibitor (cyclopiazonic acid) had significantly increased migratory capacities as mDCs regardless of SERCA2 expression.	cyclopiazonic acid	59-77	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	150-156
28264934-5	2017	Moreover, SPCA1a is blocked by micromolar concentrations of the commonly used SERCA1a inhibitors thapsigargin (Tg), cyclopiazonic acid, and 2,5-di-tert-butylhydroquinone.	cyclopiazonic acid	116-134	ATPase secretory pathway Ca2+ transporting 1	Homo sapiens	10-15
28122731-7	2017	After increase in cytosolic Ca2+ concentration ([Ca2+]cyto) with cyclopiazonic acid, calcium uptake into the mitochondria was significantly attenuated in MCECs from Cx40 KO mice compared with WT MCECs.	cyclopiazonic acid	65-83	gap junction protein, alpha 5	Mus musculus	165-169
27353380-6	2016	TPC1 and TPC2 were also shown to differentially regulate cyclopiazonic acid (CPA)-mediated changes in cytosolic free Ca(2+).	cyclopiazonic acid	57-75	two pore segment channel 1	Homo sapiens	0-4
27353380-6	2016	TPC1 and TPC2 were also shown to differentially regulate cyclopiazonic acid (CPA)-mediated changes in cytosolic free Ca(2+).	cyclopiazonic acid	57-75	two pore segment channel 2	Homo sapiens	9-13
27353380-6	2016	TPC1 and TPC2 were also shown to differentially regulate cyclopiazonic acid (CPA)-mediated changes in cytosolic free Ca(2+).	cyclopiazonic acid	77-80	two pore segment channel 1	Homo sapiens	0-4
27353380-6	2016	TPC1 and TPC2 were also shown to differentially regulate cyclopiazonic acid (CPA)-mediated changes in cytosolic free Ca(2+).	cyclopiazonic acid	77-80	two pore segment channel 2	Homo sapiens	9-13
27245842-14	2016	We also observed thapsigargin (TG)- or CPA-induced puncta formation of STIM1 and Orai1.	cyclopiazonic acid	39-42	ORAI calcium release-activated calcium modulator 1	Mus musculus	81-86
25954130-7	2015	Moreover, a cyclopiazonic acid-induced passive [Ca(2+)]i elevation was evoked by the phosphorylation of OSR1, and the amount of phosphorylated OSR1 decreased when the cells were treated with BAPTA, a Ca(2+) chelator.	cyclopiazonic acid	12-30	odd-skipped related transcription factor 1	Homo sapiens	104-108
26583319-6	2015	Consistently, palmitate upregulated ER stress proteins, oligomerized stromal interaction molecule 1 (STIM1) in the subplasmalemmal ER membrane, abolished the cyclopiazonic acid-induced cytosolic Ca(2+) increase due to depletion of luminal ER Ca(2+).	cyclopiazonic acid	158-176	stromal interaction molecule 1	Mus musculus	69-99
26583319-6	2015	Consistently, palmitate upregulated ER stress proteins, oligomerized stromal interaction molecule 1 (STIM1) in the subplasmalemmal ER membrane, abolished the cyclopiazonic acid-induced cytosolic Ca(2+) increase due to depletion of luminal ER Ca(2+).	cyclopiazonic acid	158-176	stromal interaction molecule 1	Mus musculus	101-106
26530829-4	2016	Stellate-shaped PCV mural cells expressing alpha-smooth muscle actin exhibited synchronised spontaneous Ca(2+) transients to develop vasomotion which was abolished by nifedipine (1 muM), cyclopiazonic acid (10 muM), or Ca(2+)-activated Cl(-) channel inhibitors (100 muM niflumic acid, 1 muM T16Ainh-A01).	cyclopiazonic acid	187-205	latexin	Homo sapiens	210-213
26530829-4	2016	Stellate-shaped PCV mural cells expressing alpha-smooth muscle actin exhibited synchronised spontaneous Ca(2+) transients to develop vasomotion which was abolished by nifedipine (1 muM), cyclopiazonic acid (10 muM), or Ca(2+)-activated Cl(-) channel inhibitors (100 muM niflumic acid, 1 muM T16Ainh-A01).	cyclopiazonic acid	187-205	latexin	Homo sapiens	210-213
26530829-4	2016	Stellate-shaped PCV mural cells expressing alpha-smooth muscle actin exhibited synchronised spontaneous Ca(2+) transients to develop vasomotion which was abolished by nifedipine (1 muM), cyclopiazonic acid (10 muM), or Ca(2+)-activated Cl(-) channel inhibitors (100 muM niflumic acid, 1 muM T16Ainh-A01).	cyclopiazonic acid	187-205	latexin	Homo sapiens	210-213
25805497-8	2015	LPS-triggered ENO-1 exteriorization was suppressed by pretreatment of MDA-MB-231 cells with the Ca(2+) chelator BAPTA or an inhibitor of endoplasmic reticulum Ca(2+)-ATPase pump, cyclopiazonic acid.	cyclopiazonic acid	179-197	enolase 1	Homo sapiens	14-19
25954130-7	2015	Moreover, a cyclopiazonic acid-induced passive [Ca(2+)]i elevation was evoked by the phosphorylation of OSR1, and the amount of phosphorylated OSR1 decreased when the cells were treated with BAPTA, a Ca(2+) chelator.	cyclopiazonic acid	12-30	odd-skipped related transcription factor 1	Homo sapiens	143-147
25791507-8	2015	Ginsenoside Rb1 suppressed cyclopiazonic acid (CPA)-induced PA contraction, and CPA-activated cation entry and Ca(2+) transient in PASMCs.	cyclopiazonic acid	27-45	RB transcriptional corepressor 1	Rattus norvegicus	12-15
25535724-10	2015	Mitochondrial Ca(2+) levels following CPA-induced ER depletion were significantly (p&lt;.05) diminished in TRPC1-silenced Huh7 cells.	cyclopiazonic acid	38-41	transient receptor potential cation channel subfamily C member 1	Homo sapiens	107-112
25535724-10	2015	Mitochondrial Ca(2+) levels following CPA-induced ER depletion were significantly (p&lt;.05) diminished in TRPC1-silenced Huh7 cells.	cyclopiazonic acid	38-41	MIR7-3 host gene	Homo sapiens	122-126
25535724-14	2015	The decrease in mitochondrial Ca(2+) loading following CPA-induced ER depletion in TRPC1-silenced Huh7 cells suggests a possible role of TRPC1 in hepatocellular carcinoma cell apoptosis.	cyclopiazonic acid	55-58	transient receptor potential cation channel subfamily C member 1	Homo sapiens	83-88
25535724-14	2015	The decrease in mitochondrial Ca(2+) loading following CPA-induced ER depletion in TRPC1-silenced Huh7 cells suggests a possible role of TRPC1 in hepatocellular carcinoma cell apoptosis.	cyclopiazonic acid	55-58	MIR7-3 host gene	Homo sapiens	98-102
25535724-14	2015	The decrease in mitochondrial Ca(2+) loading following CPA-induced ER depletion in TRPC1-silenced Huh7 cells suggests a possible role of TRPC1 in hepatocellular carcinoma cell apoptosis.	cyclopiazonic acid	55-58	transient receptor potential cation channel subfamily C member 1	Homo sapiens	137-142
25791507-8	2015	Ginsenoside Rb1 suppressed cyclopiazonic acid (CPA)-induced PA contraction, and CPA-activated cation entry and Ca(2+) transient in PASMCs.	cyclopiazonic acid	47-50	RB transcriptional corepressor 1	Rattus norvegicus	12-15
25791507-9	2015	ET-1 and CPA-induced contraction, and CPA-activated cation entry and Ca(2+) transients were enhanced in PA and PASMCs of CH and MCT-treated rats; the enhanced responses were abolished by ginsenoside Rb1.	cyclopiazonic acid	9-12	RB transcriptional corepressor 1	Rattus norvegicus	199-202
25791507-9	2015	ET-1 and CPA-induced contraction, and CPA-activated cation entry and Ca(2+) transients were enhanced in PA and PASMCs of CH and MCT-treated rats; the enhanced responses were abolished by ginsenoside Rb1.	cyclopiazonic acid	38-41	RB transcriptional corepressor 1	Rattus norvegicus	199-202
25352764-5	2014	Also, in the presence of Rb2 (50 microg/mL), the secretory responses of CA evoked by veratridine (a selective Na(+) channel activator (50 microM), Bay-K-8644 (an L-type dihydropyridine Ca(2+) channel activator, 10 microM), and cyclopiazonic acid (a cytoplasmic Ca(2+)-ATPase inhibitor, 10 microM) were significantly reduced, respectively.	cyclopiazonic acid	227-245	RB transcriptional corepressor like 2	Rattus norvegicus	25-28
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	92-110	endothelin receptor type A	Rattus norvegicus	26-53
25103814-5	2014	Three of the binding sites overlap with or are in close vicinity to known binding sites for various SERCA-specific inhibitors and regulators, e.g. thapsigargin, sarcolipin/phospholamban and cyclopiazonic acid.	cyclopiazonic acid	190-208	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	100-105
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	92-110	endothelin 1	Rattus norvegicus	126-138
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	112-115	endothelin receptor type A	Rattus norvegicus	40-43
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	92-110	endothelin 1	Rattus norvegicus	140-144
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	92-110	endothelin receptor type A	Rattus norvegicus	40-43
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	112-115	endothelin receptor type A	Rattus norvegicus	26-53
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	112-115	endothelin 1	Rattus norvegicus	126-138
24704610-1	2014	We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade.	cyclopiazonic acid	112-115	endothelin 1	Rattus norvegicus	140-144
24381027-4	2014	With the use of whole-cell patch-clamp recordings from the soma and dendrites of CA1 pyramidal neurons, we observed a change in h-sensitive measurements in response to SD, induced by treatment with cyclopiazonic acid, a sarcoplasmic reticulum/ER Ca(2+)-ATPase blocker.	cyclopiazonic acid	198-216	carbonic anhydrase 1	Rattus norvegicus	81-84
24129906-3	2013	In depleted fibres, poisoned with 10 muM cyclopiazonic acid SOCE influx was about 3 muM/s.	cyclopiazonic acid	41-59	latexin	Homo sapiens	37-40
24129906-3	2013	In depleted fibres, poisoned with 10 muM cyclopiazonic acid SOCE influx was about 3 muM/s.	cyclopiazonic acid	41-59	latexin	Homo sapiens	84-87
23618877-12	2013	We also found that PDGF dramatically increased the expression of fibronectin1 and collagen A1 genes, which was reversed by the use of CPA or U73122.	cyclopiazonic acid	134-137	fibronectin 1	Homo sapiens	65-77
24157978-6	2013	In arteries preincubated with 30 muM cyclopiazonic acid (CPA) or 2 muM thapsigargin (TG), the ET-1-induced Ca(2+)-release was greatly reduced, and the induced Ca(2+)-influx was attenuated.	cyclopiazonic acid	37-55	endothelin 1	Rattus norvegicus	94-98
24157978-6	2013	In arteries preincubated with 30 muM cyclopiazonic acid (CPA) or 2 muM thapsigargin (TG), the ET-1-induced Ca(2+)-release was greatly reduced, and the induced Ca(2+)-influx was attenuated.	cyclopiazonic acid	57-60	endothelin 1	Rattus norvegicus	94-98
24157978-7	2013	U-73122, a phospholipase C (PLC) inhibitor, had inhibitory effects similar to those of CPA and TG on the ET-1-induced Ca(2+)-release and Ca(2+)-influx, whereas U-73343, an inactive analogue of U-73122, had no such effects.	cyclopiazonic acid	87-90	endothelin 1	Rattus norvegicus	105-109
23723061-10	2013	In WT atria, reduction in INa could be produced by treatment with high extracellular Ca(2+), caffeine, or cyclopiazonic acid, each expected to produce an acute increase in [Ca(2+)]i.	cyclopiazonic acid	106-124	internexin neuronal intermediate filament protein, alpha	Mus musculus	26-29
23651631-5	2013	Direct and specific inhibition of SERCA2 by cyclopiazonic acid (CPA) had effects similar to IVA on LCR period and AP cycle length.	cyclopiazonic acid	44-62	sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Oryctolagus cuniculus	34-40
23651631-5	2013	Direct and specific inhibition of SERCA2 by cyclopiazonic acid (CPA) had effects similar to IVA on LCR period and AP cycle length.	cyclopiazonic acid	64-67	sarcoplasmic/endoplasmic reticulum calcium ATPase 2	Oryctolagus cuniculus	34-40
23713409-6	2013	STIM1 aggregation was analyzed by monitoring puncta size during the SR Ca(2+) depletion induced by cyclopiazonic acid (CPA).	cyclopiazonic acid	99-117	stromal interaction molecule 1	Homo sapiens	0-5
23713409-6	2013	STIM1 aggregation was analyzed by monitoring puncta size during the SR Ca(2+) depletion induced by cyclopiazonic acid (CPA).	cyclopiazonic acid	119-122	stromal interaction molecule 1	Homo sapiens	0-5
23713409-7	2013	We found that puncta size was increased in cells expressing WT-STIM1 after CPA.	cyclopiazonic acid	75-78	stromal interaction molecule 1	Homo sapiens	63-68
23828564-3	2013	Cyclopiazonic acid (CPA)-induced ER stress enhanced the IL-1beta apoptosis in INS-1E and primary rat beta cells.	cyclopiazonic acid	0-18	interleukin 1 beta	Rattus norvegicus	56-64
23828564-3	2013	Cyclopiazonic acid (CPA)-induced ER stress enhanced the IL-1beta apoptosis in INS-1E and primary rat beta cells.	cyclopiazonic acid	20-23	interleukin 1 beta	Rattus norvegicus	56-64