PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10713722-3	2000	Furthermore, it is described for the first time that the U1 snRNA molecule, which is the backbone of the U1 snRNP complex, is modified during apoptosis by the specific removal of the first 5 - 6 nucleotides including the 2,2, 7-trimethylguanosine (TMG) cap.	N(2),N(2),7-trimethylguanosine	221-246	RNA, U1 small nuclear 1	Homo sapiens	57-65
10744754-7	2000	In contrast, three closely related isoforms (IFE-1, IFE-2, and IFE-5) bind 2,2, 7-trimethylguanosine caps and are partially redundant, but at least one functional isoform is required for viability.	N(2),N(2),7-trimethylguanosine	75-100	Eukaryotic translation initiation factor 4E-1;eIF-4F 25 kDa subunit	Caenorhabditis elegans	45-50
10744754-7	2000	In contrast, three closely related isoforms (IFE-1, IFE-2, and IFE-5) bind 2,2, 7-trimethylguanosine caps and are partially redundant, but at least one functional isoform is required for viability.	N(2),N(2),7-trimethylguanosine	75-100	Eukaryotic translation initiation factor 4E-2	Caenorhabditis elegans	52-57
10744754-7	2000	In contrast, three closely related isoforms (IFE-1, IFE-2, and IFE-5) bind 2,2, 7-trimethylguanosine caps and are partially redundant, but at least one functional isoform is required for viability.	N(2),N(2),7-trimethylguanosine	75-100	Eukaryotic translation initiation factor 4E-5	Caenorhabditis elegans	63-68
15684427-3	2005	The homologs of DTL recently described include PIMT (peroxisome proliferator-activated receptor-interacting protein with a methyltransferase domain), an RNA-binding protein that interacts with and enhances the nuclear receptor coactivator function, and TGS1, the methyltransferase involved in the formation of the 2,2,7-trimethylguanosine (m3G) cap of non-coding small RNAs.	N(2),N(2),7-trimethylguanosine	314-338	Trimethylguanosine synthase 1	Drosophila melanogaster	16-19
15333938-1	2004	The nuclear import of spliceosomal UsnRNPs is mediated by the transport adaptor snurportin 1 (SPN1), which specifically recognizes the 2,2,7-trimethylguanosine (m(3)G) cap at the 5" end of UsnRNAs.	N(2),N(2),7-trimethylguanosine	135-159	snurportin 1	Homo sapiens	80-92
15333938-1	2004	The nuclear import of spliceosomal UsnRNPs is mediated by the transport adaptor snurportin 1 (SPN1), which specifically recognizes the 2,2,7-trimethylguanosine (m(3)G) cap at the 5" end of UsnRNAs.	N(2),N(2),7-trimethylguanosine	135-159	snurportin 1	Homo sapiens	94-98
12907733-1	2003	The Saccharomyces cerevisiae Tgs1 methyltransferase (MTase) is responsible for conversion of the m(7)G caps of snRNAs and snoRNAs to a 2,2,7- trimethylguanosine structure.	N(2),N(2),7-trimethylguanosine	135-160	RNA methyltransferase	Saccharomyces cerevisiae S288C	29-33
10713722-3	2000	Furthermore, it is described for the first time that the U1 snRNA molecule, which is the backbone of the U1 snRNP complex, is modified during apoptosis by the specific removal of the first 5 - 6 nucleotides including the 2,2, 7-trimethylguanosine (TMG) cap.	N(2),N(2),7-trimethylguanosine	221-246	RNA binding region (RNP1, RRM) containing 3	Homo sapiens	105-113
35484160-0	2022	TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance.	N(2),N(2),7-trimethylguanosine	14-39	trimethylguanosine synthase 1	Homo sapiens	0-4
9576861-6	1998	Anti-2,2,7-trimethylguanosine affinity chromatography was an easy and efficient way of purifying the multi-snRNP complex from rat liver 40 S heterogeneous nuclear ribonucleoprotein particle (hnRNP)-containing sucrose gradient fractions.	N(2),N(2),7-trimethylguanosine	5-29	heterogeneous nuclear ribonucleoprotein A2/B1	Rattus norvegicus	191-196
8371343-4	1993	Splicing snRNPs were independently detected with both monoclonal and polyclonal antibodies specific for common snRNP antigens, snRNP-specific proteins, and the snRNA-specific 2,2,7-trimethylguanosine 5" cap structure.	N(2),N(2),7-trimethylguanosine	175-199	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	9-14
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	80-104	trimethylguanosine synthase 1	Homo sapiens	167-196
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	80-104	trimethylguanosine synthase 1	Homo sapiens	198-202
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	106-109	trimethylguanosine synthase 1	Homo sapiens	167-196
35484160-2	2022	Using human lung cancer cells and tumor organoids we show that formation of the 2,2,7-trimethylguanosine (TMG) cap structure at the human telomerase RNA 5" end by the Trimethylguanosine Synthase 1 (TGS1) is central for recruiting telomerase to telomeres and engaging Cajal bodies in telomere maintenance.	N(2),N(2),7-trimethylguanosine	106-109	trimethylguanosine synthase 1	Homo sapiens	198-202
22982455-2	2012	As a transcription coactivator binding protein, PIMT enhances the nuclear receptor transcriptional activity and its methyltransferase property is involved in the formation of the 2,2,7-trimethylguanosine cap of non-coding small RNAs, but the in vivo functions of this gene have not been fully explored.	N(2),N(2),7-trimethylguanosine	179-203	trimethylguanosine synthase 1	Mus musculus	48-52
2959477-1	1987	A hybridoma secreting a monoclonal antibody (H-20) that recognizes the 2,2,7-trimethylguanosine(m3G)-containing cap structure of U snRNAs was derived from a mouse which was immunized with a m3G-containing human serum albumin conjugate.	N(2),N(2),7-trimethylguanosine	71-95	histocompatibility 20	Mus musculus	45-49
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	124-148	trimethylguanosine synthase 1	Homo sapiens	166-195
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	124-148	trimethylguanosine synthase 1	Homo sapiens	197-201
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	124-148	exportin 1	Homo sapiens	251-261
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	124-148	exportin 1	Homo sapiens	263-267
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	150-153	trimethylguanosine synthase 1	Homo sapiens	166-195
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	150-153	trimethylguanosine synthase 1	Homo sapiens	197-201
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	150-153	exportin 1	Homo sapiens	251-261
29527542-5	2018	Indeed, we have identified a group of pri-miRNAs (whose mature miRNAs were found induced during quiescence) modified with a 2,2,7-trimethylguanosine (TMG)-cap by the trimethylguanosine synthase 1 (TGS1) protein and transported to the cytoplasm by the Exportin-1 (XPO1) protein.	N(2),N(2),7-trimethylguanosine	150-153	exportin 1	Homo sapiens	263-267
28584122-4	2017	Moreover, these quiescence-induced primary miRNAs (pri-miRNAs) are modified with a 2,2,7-trimethylguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible for (TMG)-capping, inhibits their biogenesis.	N(2),N(2),7-trimethylguanosine	83-107	exportin 1	Homo sapiens	142-152
28584122-4	2017	Moreover, these quiescence-induced primary miRNAs (pri-miRNAs) are modified with a 2,2,7-trimethylguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible for (TMG)-capping, inhibits their biogenesis.	N(2),N(2),7-trimethylguanosine	109-112	exportin 1	Homo sapiens	142-152
28584122-4	2017	Moreover, these quiescence-induced primary miRNAs (pri-miRNAs) are modified with a 2,2,7-trimethylguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible for (TMG)-capping, inhibits their biogenesis.	N(2),N(2),7-trimethylguanosine	109-112	exportin 1	Homo sapiens	171-181
28584122-4	2017	Moreover, these quiescence-induced primary miRNAs (pri-miRNAs) are modified with a 2,2,7-trimethylguanosine (TMG)-cap, which is known to bind Exportin-1, and knockdown of Exportin-1 or trimethylguanosine synthase 1, responsible for (TMG)-capping, inhibits their biogenesis.	N(2),N(2),7-trimethylguanosine	109-112	trimethylguanosine synthase 1	Homo sapiens	185-214
26074133-1	2015	Trimethylguanosine Synthase catalyses transfer of two methyl groups to the m(7)G cap of RNA polymerase II transcribed snRNAs, snoRNAs, and telomerase RNA TLC1 to form a 2,2,7-trimethylguanosine cap.	N(2),N(2),7-trimethylguanosine	169-193	trimethylguanosine synthase 1	Homo sapiens	0-27
21398639-1	2011	Tgs1 is the enzyme that converts m(7)G RNA caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs.	N(2),N(2),7-trimethylguanosine	55-79	RNA methyltransferase	Saccharomyces cerevisiae S288C	0-4
21398639-1	2011	Tgs1 is the enzyme that converts m(7)G RNA caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs.	N(2),N(2),7-trimethylguanosine	81-84	RNA methyltransferase	Saccharomyces cerevisiae S288C	0-4
21398639-6	2011	The TMG requirement for PCH2 splicing is alleviated by a CACUAAC to UACUAAC change restoring a consensus branchpoint and by shortening the PCH2 5" exon.	N(2),N(2),7-trimethylguanosine	4-7	Pch2p	Saccharomyces cerevisiae S288C	24-28
21398639-6	2011	The TMG requirement for PCH2 splicing is alleviated by a CACUAAC to UACUAAC change restoring a consensus branchpoint and by shortening the PCH2 5" exon.	N(2),N(2),7-trimethylguanosine	4-7	Pch2p	Saccharomyces cerevisiae S288C	139-143
19926722-6	2010	In contrast, Giardia lamblia Tgs (GlaTgs2) exemplifies a different clade of guanine-N2 methyltransferase that synthesizes only a dimethylguanosine (DMG) cap structure and cannot per se convert DMG to TMG under any conditions tested.	N(2),N(2),7-trimethylguanosine	200-203	lin-9 DREAM MuvB core complex component	Homo sapiens	29-32
20360394-1	2010	Yeast and human Tgs1 are orthologous RNA cap (guanine-N2) methyltransferases that convert m(7)G caps into the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs.	N(2),N(2),7-trimethylguanosine	110-134	trimethylguanosine synthase 1	Homo sapiens	16-20
20360394-1	2010	Yeast and human Tgs1 are orthologous RNA cap (guanine-N2) methyltransferases that convert m(7)G caps into the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal snRNAs.	N(2),N(2),7-trimethylguanosine	136-139	trimethylguanosine synthase 1	Homo sapiens	16-20
19386620-2	2009	The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the RNPs.	N(2),N(2),7-trimethylguanosine	102-126	trimethylguanosine synthase 1	Homo sapiens	4-33
19386620-2	2009	The Trimethylguanosine Synthase 1 (TGS1) mediates this conversion of the 7-methylguanosine-cap to the 2,2,7-trimethylguanosine (m(3)G)-cap during maturation of the RNPs.	N(2),N(2),7-trimethylguanosine	102-126	trimethylguanosine synthase 1	Homo sapiens	35-39
18775984-0	2008	Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways.	N(2),N(2),7-trimethylguanosine	107-131	trimethylguanosine synthase 1	Homo sapiens	56-83
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	90-114	trimethylguanosine synthase 1	Homo sapiens	0-27
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	90-114	trimethylguanosine synthase 1	Homo sapiens	29-33
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	116-119	trimethylguanosine synthase 1	Homo sapiens	0-27
18775984-1	2008	Trimethylguanosine synthase (Tgs1) is the enzyme that converts standard m(7)G caps to the 2,2,7-trimethylguanosine (TMG) caps characteristic of spliceosomal small nuclear RNAs.	N(2),N(2),7-trimethylguanosine	116-119	trimethylguanosine synthase 1	Homo sapiens	29-33