PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34925274-5	2021	Here, we present the results for binding of two such AIE probes, phosphonic acid derivative of tetraphenyl ethylene (TPE-P) and sulfonic acid derivative of tetraphenyl ethylene (TPE-S), to SARS-CoV-2 spike protein based on in silico docking studies.	tetraphenylethylene	95-115	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	200-205
34952244-2	2022	In this study, we reported an innovative H2O2-responsive amphiphilic polymer (TBP), bearing a H2O2-sensitive phenylboronic ester, AIE fluorophore tetraphenylethene (TPE) hydrophobic, and polyethylene glycol hydrophilic (PEG) moieties.	tetraphenylethylene	146-163	TATA box binding protein	Mus musculus	78-81
34925274-5	2021	Here, we present the results for binding of two such AIE probes, phosphonic acid derivative of tetraphenyl ethylene (TPE-P) and sulfonic acid derivative of tetraphenyl ethylene (TPE-S), to SARS-CoV-2 spike protein based on in silico docking studies.	tetraphenylethylene	156-176	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	200-205
34647456-3	2021	In detail, an asymmetric aggregation-induced-emission active molecule (azobenzol-decorated tetraphenylethylene, i.e., TPE-Azo) was embedded into flexible poly(ethylene-alt-maleic anhydride) (PEM) to prepare a TPE-Azo@PEM composite, which served as an active layer to fabricate the FTO/TPE-Azo@PEM/Ag device.	tetraphenylethylene	91-110	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	281-284
34787133-3	2021	In this work, we employed ab initio simulations to investigate the AIE mechanism of two tetraphenylethylene derivatives recently developed for sensitive detection of human serum albumin (HSA) in biological fluids.	tetraphenylethylene	88-107	albumin	Homo sapiens	172-185
34160129-6	2021	With a flexible motor, tetraphenylethene, bridged to the rigidified coplanar core boron-azadipyrromethene, the desired CCNU-1060 is subsequently encapsulated into an amphiphilic matrix to form CCNU-1060 nanoparticles (NPs), which match or transcend its precursor NJ-1060 NPs in the three energy dissipation processes.	tetraphenylethylene	23-40	cyclin O	Homo sapiens	119-123
34160129-6	2021	With a flexible motor, tetraphenylethene, bridged to the rigidified coplanar core boron-azadipyrromethene, the desired CCNU-1060 is subsequently encapsulated into an amphiphilic matrix to form CCNU-1060 nanoparticles (NPs), which match or transcend its precursor NJ-1060 NPs in the three energy dissipation processes.	tetraphenylethylene	23-40	cyclin O	Homo sapiens	193-197
35635289-1	2022	A coumarin coupled tetraphenylethylene based AIEgen (TPE-Lac) with an intense greenish-yellow emission has been synthesized and utilized for multipurpose sensing and imaging applications.	tetraphenylethylene	19-38	lactase	Homo sapiens	57-60
34264383-1	2021	A covalent organic framework (COF) with aggregation-induced emission (AIE) property was successfully synthesized through in situ marriage of a commonly used AIE molecule tetraphenylethylene (TPE) with Schiff base network (SNW-1) through a simple one-pot method.	tetraphenylethylene	170-189	SNW domain containing 1	Homo sapiens	222-227
34264383-1	2021	A covalent organic framework (COF) with aggregation-induced emission (AIE) property was successfully synthesized through in situ marriage of a commonly used AIE molecule tetraphenylethylene (TPE) with Schiff base network (SNW-1) through a simple one-pot method.	tetraphenylethylene	191-194	SNW domain containing 1	Homo sapiens	222-227
35611940-1	2022	A high-throughput tetraphenylethylene (TPE)-based fluorescent sensor array was constructed for the identification and detection of microorganisms, which utilizes three TPE derivatives with different numbers of cationic side chains to detect and discriminate various microorganisms at concentrations down to 1 x 103 CFU mL-1.	tetraphenylethylene	18-37	L1 cell adhesion molecule	Mus musculus	319-323
33634292-1	2021	Two tetraphenylethene-based tetracationic cyclophanes 1 and 2 were synthesized via a one-step SN2 reaction without using any template.	tetraphenylethylene	4-21	solute carrier family 38 member 5	Homo sapiens	94-97
33724636-2	2021	Herein, a series of tetraphenylethylene-based multicomponent emissive metallacages are prepared by the coordination-driven self-assembly of tetra-(4-pyridylphenyl)ethylene, cis-Pt(PEt 3 ) 2 (OTf) 2 and tetracarboxylic ligands.	tetraphenylethylene	20-39	POU class 2 homeobox 2	Homo sapiens	180-197
35611940-1	2022	A high-throughput tetraphenylethylene (TPE)-based fluorescent sensor array was constructed for the identification and detection of microorganisms, which utilizes three TPE derivatives with different numbers of cationic side chains to detect and discriminate various microorganisms at concentrations down to 1 x 103 CFU mL-1.	tetraphenylethylene	39-42	L1 cell adhesion molecule	Mus musculus	319-323
35611940-1	2022	A high-throughput tetraphenylethylene (TPE)-based fluorescent sensor array was constructed for the identification and detection of microorganisms, which utilizes three TPE derivatives with different numbers of cationic side chains to detect and discriminate various microorganisms at concentrations down to 1 x 103 CFU mL-1.	tetraphenylethylene	168-171	L1 cell adhesion molecule	Mus musculus	319-323
33648642-2	2021	Organic fluorophore (named TPE-TA) consists of tetraphenylethylene (TPE, sensing and signaling moiety) and mono-triamine (TA, sensing moiety), and it forms an aggregated form in aqueous media as a nanoprobe AAP-1.	tetraphenylethylene	27-30	RING1 and YY1 binding protein	Homo sapiens	207-212
31944424-2	2020	Herein, AIE active tetraphenylethene functionalized pyrazoline derivatives with various non-conjugated substituent groups (Br, F, N,N-dimethylamino and cyano groups for TPEB, TPEF, TPEN and TPECN) were designed and synthesized.	tetraphenylethylene	19-36	transmembrane protein with EGF like and two follistatin like domains 2	Homo sapiens	175-179
33656311-2	2021	Hybrid films were prepared with a spin-coating method with the mixture solution containing tetraphenylethene (TPE)-integrated polyhedral oligomeric silsesquioxane (POSS) and poly[2-methoxy-5-(2"-ethylhexyloxy)-1,4-phenylene vinylene] (MEH-PPV).	tetraphenylethylene	91-108	epoxide hydrolase 1	Homo sapiens	235-238
33331135-2	2021	In this work, we designed an amphiphilic hydrazone fluorescent molecule THG-1 containing hydrophilic sugar units and hydrophobic tetraphenylethylene unit for ratiometric detection of HOCl with high sensitivity and excellent selectivity based on HOCl-triggered hydrolyzation reaction and aggregation-induced emission (AIE) effect.	tetraphenylethylene	129-148	TSC22 domain family member 4	Homo sapiens	72-77
33197192-0	2020	Fast Nonadiabatic Molecular Dynamics via Spin-Flip Time-Dependent Density-Functional Tight-Binding Approach: Application to Nonradiative Relaxation of Tetraphenylethylene with Locked Aromatic Rings.	tetraphenylethylene	151-170	spindlin 1	Homo sapiens	41-45
31647490-0	2019	A fluorescent nanoparticle probe based on sugar-substituted tetraphenylethene for label-free detection of galectin-3.	tetraphenylethylene	60-77	galectin 3	Homo sapiens	106-116
31711724-2	2020	Inspired from the unique aggregation-induced emission (AIE) feature, in the current study, novel tetraphenylethylene (TPE) derivatives are prepared containing sulfonic groups for water solubility modulation and carboxyl dithioacetals for Hg2+ sensing.	tetraphenylethylene	97-116	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	238-241
28265596-2	2017	In this report, a new fluorescent probe, namely, DEVD-TPE, which consisted of the substrate peptide Asp-Glu-Val-Asp (DEVD) and the AIE reporter group tetraphenylethene (TPE), was developed for detecting caspase-3 in living cells.	tetraphenylethylene	150-167	caspase 3	Homo sapiens	203-212
31536063-2	2019	Fluorescent silica nanoparticles (TSiO2) with excellent performance were prepared using a tetraphenylethylene based probe (TPE-C4-4) to produce a controlled aggregation effect, and HE4 was detected using antibody-functionalized fluorescent silica nanoparticles.	tetraphenylethylene	90-109	WAP four-disulfide core domain 2	Homo sapiens	181-184
30724078-0	2019	Electrochemiluminescence Enhanced by Restriction of Intramolecular Motions (RIM): Tetraphenylethylene Microcrystals as a Novel Emitter for Mucin 1 Detection.	tetraphenylethylene	82-101	mucin 1, cell surface associated	Homo sapiens	139-146
31458237-1	2018	A novel tetraphenylethylene-based ladder network (MP1) made by polycondensation reaction from 4,4",4"",4"""-(ethene-1,1,2,2-tetrayl)tetrakis(benzene-1,2-diol) and 2,3,5,6-tetrafluoroterephthalonitrile and its COOH-functionalized analogue (MP2) were synthesized for the first time.	tetraphenylethylene	8-27	pitrilysin metallopeptidase 1	Homo sapiens	50-53
31458237-1	2018	A novel tetraphenylethylene-based ladder network (MP1) made by polycondensation reaction from 4,4",4"",4"""-(ethene-1,1,2,2-tetrayl)tetrakis(benzene-1,2-diol) and 2,3,5,6-tetrafluoroterephthalonitrile and its COOH-functionalized analogue (MP2) were synthesized for the first time.	tetraphenylethylene	8-27	tryptase pseudogene 1	Homo sapiens	239-242
28741111-3	2017	The positively charged amino-functionalized SiO2 NPs were used as efficient nanocapturer to electrostatically adsorb single-stranded PSA aptamer (PA) to form SiO2 NP-PA nanocomposite as well as adsorb negatively charged tetraphenylethylene derivative 3 (TPE3) to form AIE-SiO2 NP nanocomposite.	tetraphenylethylene	220-239	kallikrein related peptidase 3	Homo sapiens	133-136
28011417-2	2017	In the current study, a ratiometric assay of ALP activity has been realized by covalent immobilization of fluorescein onto polyethylene terephthalate (PET) fibers, followed by electrostatic adsorption of bisquaternary ammonium salt of tetraphenylethene (TPE-2N+).	tetraphenylethylene	235-252	alkaline phosphatase, placental	Homo sapiens	45-48
28383580-0	2017	A selective and light-up fluorescent probe for beta-galactosidase activity detection and imaging in living cells based on an AIE tetraphenylethylene derivative.	tetraphenylethylene	129-148	galactosidase beta 1	Homo sapiens	47-65
31556436-1	2019	A newly prepared tetraphenylethylene-based (TPE-based) covalent organic polymer (COP) named COP-1 exhibits high selectivity for sensing Fe3+ and the limit of detection (LOD) for Fe3+ is 0.42 muM, which is lower than the reported metal-free porous polymers.	tetraphenylethylene	17-36	caspase recruitment domain family member 16	Homo sapiens	92-97
31534506-3	2019	Methods: In this study, we have successfully fabricated and characterized the dual-targeted gold nanoprisms, whereby bare gold nanoprisms (Au NPR) were conjugated to a phenanthroline derivatives-functionalized tetraphenylethene (TPE) and further stabilized with target peptide aptamers via Au-S bonds (Au-Apt-TPE).	tetraphenylethylene	210-227	neuronal pentraxin receptor	Homo sapiens	142-145
31087691-1	2019	The development of highly emissive dinuclear AgI or AuI complexes [M2 L](PF6 )2 (L=2 a, 2 b; M=Ag, Au) derived from tetraphenylethylene (TPE)-based tetrabenzimidazolin-2-ylidene ligands is reported.	tetraphenylethylene	116-135	sperm associated antigen 17	Homo sapiens	73-76
31087691-1	2019	The development of highly emissive dinuclear AgI or AuI complexes [M2 L](PF6 )2 (L=2 a, 2 b; M=Ag, Au) derived from tetraphenylethylene (TPE)-based tetrabenzimidazolin-2-ylidene ligands is reported.	tetraphenylethylene	137-140	sperm associated antigen 17	Homo sapiens	73-76
31125220-3	2019	Herein, two distinct exo- and endo-functionalized tetraphenylethylene (TPE)-based M12L24 nanospheres with precise distribution of anchored TPE moieties and unique photophysical properties were constructed by means of a coordination-driven self-assembly strategy.	tetraphenylethylene	50-69	mannosidase endo-alpha	Homo sapiens	30-34
31125220-3	2019	Herein, two distinct exo- and endo-functionalized tetraphenylethylene (TPE)-based M12L24 nanospheres with precise distribution of anchored TPE moieties and unique photophysical properties were constructed by means of a coordination-driven self-assembly strategy.	tetraphenylethylene	71-74	mannosidase endo-alpha	Homo sapiens	30-34
29116746-1	2018	In this paper, we report Zincke"s salt-substituted tetraphenylethylenes 1a and 1b with Cl- and PF6- as counteranions, respectively.	tetraphenylethylene	51-71	sperm associated antigen 17	Homo sapiens	95-98
29439558-3	2018	Herein, we present a kind of dual responding self-assembled nanotransformation material that is tumor angiogenesis targeting and pH triggered based on amphiphilic conjugation between peptides (STP) and aromatic molecules (tetraphenylethylene (TPE)).	tetraphenylethylene	222-241	thyroid hormone receptor interactor 10	Homo sapiens	193-196
29439558-3	2018	Herein, we present a kind of dual responding self-assembled nanotransformation material that is tumor angiogenesis targeting and pH triggered based on amphiphilic conjugation between peptides (STP) and aromatic molecules (tetraphenylethylene (TPE)).	tetraphenylethylene	243-246	thyroid hormone receptor interactor 10	Homo sapiens	193-196
29313689-0	2018	Porous Interdigitation Molecular Cage from Tetraphenylethylene Trimeric Macrocycles That Showed Highly Selective Adsorption of CO2 and TNT Vapor in Air.	tetraphenylethylene	43-62	chromosome 16 open reading frame 82	Homo sapiens	135-138
28573846-5	2017	Using imidazopyrazinone (CLA) as the reactive motif and tetraphenylethene (TPE) as FL/CL enhancing skeleton, TPE-CLA is sensitive enough to image native O2 - in Raw264.7 cells and lipopolysaccharide stimulated O2 - in mice.	tetraphenylethylene	56-73	clasper	Mus musculus	113-116
27439180-1	2016	A novel tetraphenylethene-based fluorescent sensor, TPE-T, was developed for the detection of uranyl ions.	tetraphenylethylene	8-25	T-box transcription factor 21	Homo sapiens	52-57
27183282-2	2016	Herein a turn-on fluorescent probe for gamma-glutamyl transpeptidase (GGT) assay based on aggregation-induced-emission (AIE) effect and the enzyme-induced transformation of hydrophilicity to hydrophobicity has been developed by functionalizing tetraphenylethylene (TPE) derivative with two gamma-glutamyl amide groups, which simultaneously work as recognition units and hydrophilic groups.	tetraphenylethylene	244-263	inactive glutathione hydrolase 2	Homo sapiens	39-68
27183282-2	2016	Herein a turn-on fluorescent probe for gamma-glutamyl transpeptidase (GGT) assay based on aggregation-induced-emission (AIE) effect and the enzyme-induced transformation of hydrophilicity to hydrophobicity has been developed by functionalizing tetraphenylethylene (TPE) derivative with two gamma-glutamyl amide groups, which simultaneously work as recognition units and hydrophilic groups.	tetraphenylethylene	244-263	inactive glutathione hydrolase 2	Homo sapiens	70-73
27183282-2	2016	Herein a turn-on fluorescent probe for gamma-glutamyl transpeptidase (GGT) assay based on aggregation-induced-emission (AIE) effect and the enzyme-induced transformation of hydrophilicity to hydrophobicity has been developed by functionalizing tetraphenylethylene (TPE) derivative with two gamma-glutamyl amide groups, which simultaneously work as recognition units and hydrophilic groups.	tetraphenylethylene	265-268	inactive glutathione hydrolase 2	Homo sapiens	39-68
27183282-2	2016	Herein a turn-on fluorescent probe for gamma-glutamyl transpeptidase (GGT) assay based on aggregation-induced-emission (AIE) effect and the enzyme-induced transformation of hydrophilicity to hydrophobicity has been developed by functionalizing tetraphenylethylene (TPE) derivative with two gamma-glutamyl amide groups, which simultaneously work as recognition units and hydrophilic groups.	tetraphenylethylene	265-268	inactive glutathione hydrolase 2	Homo sapiens	70-73
28074644-3	2017	Herein, inspired by viral structures that are optimized for gene delivery, we designed a small-molecule gene vector (TR4) with aggregation-induced emission properties by capping a peptide containing four arginine residues with tetraphenylethene (TPE) and a lipophilic tail.	tetraphenylethylene	227-244	nuclear receptor subfamily 2 group C member 2	Homo sapiens	117-120
27498323-4	2016	Herein, we reported a simple paper-based fluorescent sensor (PFS) based on the aggregation induced emission (AIE) effect of tetraphenylethylene (TPE) and the addition reaction capability of maleimide, which has been used as a powerful tool for rapid naked-eye detection of AChE activity and OPs.	tetraphenylethylene	124-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	273-277
27616191-1	2016	A high contrast tri-state fluorescent switch (FSPTPE) with both emission color change and on/off switching is achieved in a single molecular system by fusing the aggregation-induced emissive tetraphenylethene (TPE) with a molecular switch of spiropyran (SP).	tetraphenylethylene	191-208	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	16-19
27474306-1	2016	We develop a new lysosome-targeting AIE fluorescent probe tetraphenylethene-morpholine (TPE-MPL), by incorporating a typical lysosome-targeting moiety of morpholine into a stable tetraphenylethene skeleton.	tetraphenylethylene	58-75	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	92-95
22298493-3	2012	Tetraphenylethene (TPE)-containing hb-P1/2 fluoresced faintly in THF, although its light emission was enhanced by aggregate formation in aqueous media or in thin films, thereby exhibiting an aggregation-induced emission-enhancement (AIEE) effect.	tetraphenylethylene	0-17	BBX high mobility group box domain containing	Homo sapiens	35-42
32263396-3	2016	In this work, three phosphorylated tetraphenylethylene (TPE) probes (TPE-PA, TPE-2PA and TPE-4PA) with different numbers of -PO3H2 groups were synthesized for monitoring the ALP activity.	tetraphenylethylene	35-54	alkaline phosphatase, placental	Homo sapiens	174-177
32263396-3	2016	In this work, three phosphorylated tetraphenylethylene (TPE) probes (TPE-PA, TPE-2PA and TPE-4PA) with different numbers of -PO3H2 groups were synthesized for monitoring the ALP activity.	tetraphenylethylene	56-59	alkaline phosphatase, placental	Homo sapiens	174-177
24824627-1	2014	We report a 2D layered metal-organic framework (MOF) with wide channels named NUS-1 and its activated analogue NUS-1a composed of Zn4O-like secondary building units and tetraphenylethene (TPE)-based ligand 4,4"-(2,2-diphenylethene-1,1-diyl)dibenzoic acid.	tetraphenylethylene	169-186	NUS1 dehydrodolichyl diphosphate synthase subunit	Homo sapiens	78-83
32261179-0	2013	Incorporation of tyrosine phosphate into tetraphenylethylene affords an amphiphilic molecule for alkaline phosphatase detection, hydrogelation and calcium mineralization.	tetraphenylethylene	41-60	alkaline phosphatase, placental	Homo sapiens	97-117
23957823-2	2013	In this work, we designed and synthesized an AIE fluorescent probe by functionalizing a tetraphenylethylene (TPE) fluorogen with two phosphate groups (TPE-phos) for the detection of alkaline phosphatase (ALP) and its enzymatic activity based on the specific interaction between the probe and ALP.	tetraphenylethylene	88-107	alkaline phosphatase, placental	Homo sapiens	182-202
23957823-2	2013	In this work, we designed and synthesized an AIE fluorescent probe by functionalizing a tetraphenylethylene (TPE) fluorogen with two phosphate groups (TPE-phos) for the detection of alkaline phosphatase (ALP) and its enzymatic activity based on the specific interaction between the probe and ALP.	tetraphenylethylene	88-107	alkaline phosphatase, placental	Homo sapiens	204-207
26887358-5	2016	According to these mechanisms, we suggest that a water-miscible tetraphenylethene BSPOTPE is a potent inhibitor to rescue hIAPP-induced cytotoxicity.	tetraphenylethylene	64-81	islet amyloid polypeptide	Homo sapiens	122-127
26089125-1	2015	A quadrangular prismatic tricyclooxacalixarene cage 1 based on tetraphenylethylene (TPE) was efficiently synthesized by a one-pot S(N)Ar condensation reaction.	tetraphenylethylene	63-82	cancer antigen 1	Homo sapiens	47-53
26089125-1	2015	A quadrangular prismatic tricyclooxacalixarene cage 1 based on tetraphenylethylene (TPE) was efficiently synthesized by a one-pot S(N)Ar condensation reaction.	tetraphenylethylene	84-87	cancer antigen 1	Homo sapiens	47-53
24819882-2	2014	Thus, a new tetraphenylethylene-based zirconium MOF exhibits a deep-blue fluorescent emission at 470 nm with a unity quantum yield (99.9 +- 0.5%) under Ar, representing ca.	tetraphenylethylene	12-31	lysine acetyltransferase 8	Homo sapiens	48-51
23462951-0	2013	A new fluorometric turn-on assay for alkaline phosphatase and inhibitor screening based on aggregation and deaggregation of tetraphenylethylene molecules.	tetraphenylethylene	124-143	alkaline phosphatase, placental	Homo sapiens	37-57
23081687-1	2012	We report the optical properties of tetraphenylethene (TPE) and other TPE derivatives functionalised with an octyl group (TPE-OCT) and polyethyleneglycol group (TPE-PEG) in the side chain.	tetraphenylethylene	36-53	plexin A2	Homo sapiens	126-129
20704392-3	2010	A nonemissive tetraphenylethene derivative named sodium 1,2-bis[4-(3-sulfonatopropoxyl)phenyl]-1,2-diphenylethene (BSPOTPE) is induced to emit by HSA, showing a novel phenomenon of aggregation-induced emission (AIE).	tetraphenylethylene	14-31	albumin	Homo sapiens	146-149
21491028-0	2011	BSA-tetraphenylethene derivative conjugates with aggregation-induced emission properties: fluorescent probes for label-free and homogeneous detection of protease and alpha1-antitrypsin.	tetraphenylethylene	4-21	serpin family A member 1	Homo sapiens	166-184
21491028-1	2011	Herein, BSA-tetraphenylethene derivative conjugates with aggregation-induced emission (AIE) properties were constructed and used as fluorescent probes for label-free detection of protease and alpha1-antitrypsin.	tetraphenylethylene	12-29	serpin family A member 1	Homo sapiens	192-210
22021020-1	2011	Stereoregular tetraphenylethene derivatives (Z)-o-BCaPTPE and (Z)-o-BTPATPE featured with chiasmatic conformations and aggregation-enhanced emission characteristics are synthesized using a McMurry reaction.	tetraphenylethylene	14-31	protein tyrosine phosphatase receptor type E	Homo sapiens	50-57
19374428-1	2009	A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE).	tetraphenylethylene	177-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-82
19374428-1	2009	A new convenient and continuous fluorometric assay method for acetylcholinesterase (AChE) and its inhibitor screening is successfully established with the ensemble of 1 [a TPE (tetraphenylethylene) compound with two sulfonate (-SO(3)(-)) units] and myristoylcholine (an amphiphilic compound as a good substrate of AChE).	tetraphenylethylene	177-196	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-88