PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28210006-4	2017	NCD38 elevated H3K27ac level on enhancers of these LSD1 signature genes and newly activated ~500 super-enhancers.	h3k27ac	15-22	lysine demethylase 1A	Homo sapiens	51-55
31808546-6	2020	Furthermore, we identified a reduction of H3K27ac level binding at the BACH2 locus in the SLE Fr.III cells and SLE serum stimulation decreased H3K27ac binding at the BACH2 locus, which could be restored using trichostatin A (TSA).	h3k27ac	42-49	BTB domain and CNC homolog 2	Homo sapiens	71-76
31808546-6	2020	Furthermore, we identified a reduction of H3K27ac level binding at the BACH2 locus in the SLE Fr.III cells and SLE serum stimulation decreased H3K27ac binding at the BACH2 locus, which could be restored using trichostatin A (TSA).	h3k27ac	42-49	BTB domain and CNC homolog 2	Homo sapiens	166-171
30933372-3	2019	Using analysis of genome-wide histone modifications, DNA methylation, and hydroxymethylation in mouse hepatocytes, we show that HNF4A occupies active enhancers in hepatocytes and is essential for active histone and DNA signatures, especially acetylation of lysine 27 of histone 3 (H3K27ac) and 5-hydroxymethylcytosine (5hmC).	h3k27ac	281-288	hepatic nuclear factor 4, alpha	Mus musculus	128-133
35400201-8	2022	Intriguingly, we discovered that the DCM-enriched H3K27ac loop anchors exhibited a strong enrichment for Heart and Neural Crest Derivatives Expressed 1 (HAND1), a key transcription factor involved in early cardiogenesis.	h3k27ac	50-57	heart and neural crest derivatives expressed 1	Mus musculus	150-151
34358374-0	2021	H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3.	h3k27ac	0-7	forkhead box C2	Homo sapiens	16-21
34358374-0	2021	H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3.	h3k27ac	0-7	prostaglandin D2 receptor	Homo sapiens	22-25
34358374-0	2021	H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3.	h3k27ac	0-7	E2F transcription factor 3	Homo sapiens	85-89
34108034-0	2021	H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis.	h3k27ac	0-7	PAX interacting protein 1	Homo sapiens	23-29
34108034-0	2021	H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis.	h3k27ac	0-7	prostaglandin D2 receptor	Homo sapiens	30-33
34108034-0	2021	H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis.	h3k27ac	0-7	microRNA 6744	Homo sapiens	123-131
34108034-0	2021	H3K27ac-induced lncRNA PAXIP1-AS1 promotes cell proliferation, migration, EMT and apoptosis in ovarian cancer by targeting miR-6744-5p/PCBP2 axis.	h3k27ac	0-7	poly(rC) binding protein 2	Homo sapiens	135-140
35400201-8	2022	Intriguingly, we discovered that the DCM-enriched H3K27ac loop anchors exhibited a strong enrichment for Heart and Neural Crest Derivatives Expressed 1 (HAND1), a key transcription factor involved in early cardiogenesis.	h3k27ac	50-57	heart and neural crest derivatives expressed 1	Mus musculus	153-158
33334824-7	2021	Using an acute degradation system, we found that the histone acetyltransferases P300 and CBP maintained H3K27ac abundance and facilitated NIPBL occupancy at enhancers and that active transcriptional elongation is essential to maintain H3K27ac abundance.	h3k27ac	104-111	CREB binding protein	Homo sapiens	89-92
34039742-8	2021	We also found that knockdown of CRED9 in Hep3B cells caused a 57.8% reduction in H3K27ac levels at the +9kb CEBPA enhancer.	h3k27ac	81-88	CCAAT enhancer binding protein alpha	Homo sapiens	108-113
33462242-5	2021	Moreover, RUNX1 shapes LSC chromatin architecture via modulating H3K27ac deposition.	h3k27ac	65-72	RUNX family transcription factor 1	Homo sapiens	10-15
32735773-9	2020	In conclusion, we demonstrated that H3K27ac modification-induced upregulation of ZNF649-AS1 could cause autophagy and trastuzumab resistance through associating with PTBP1 and promoting ATG5 transcription.	h3k27ac	36-43	ZNF649 antisense RNA 1	Homo sapiens	81-91
32735773-9	2020	In conclusion, we demonstrated that H3K27ac modification-induced upregulation of ZNF649-AS1 could cause autophagy and trastuzumab resistance through associating with PTBP1 and promoting ATG5 transcription.	h3k27ac	36-43	polypyrimidine tract binding protein 1	Homo sapiens	166-171
32735773-9	2020	In conclusion, we demonstrated that H3K27ac modification-induced upregulation of ZNF649-AS1 could cause autophagy and trastuzumab resistance through associating with PTBP1 and promoting ATG5 transcription.	h3k27ac	36-43	autophagy related 5	Homo sapiens	186-190