PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35203668-3	2022	Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs.	srls	107-111	cadherin 1	Homo sapiens	28-38
35203668-4	2022	Our aim was to study EMT and its relationship with SRLs resistance in GH-producing tumors.	srls	51-55	growth hormone 1	Homo sapiens	70-72
35203668-6	2022	The postsurgical response to SRLs was categorized as complete response, partial response, or nonresponse if IGF-1 was normal, had decreased more than 30% without normalization, or neither of those, respectively.	srls	29-33	insulin like growth factor 1	Homo sapiens	108-113
35203668-9	2022	RORC was overexpressed in tumors treated with SRLs before surgery, and this increased expression was more prominent in those cases that normalized postsurgical IGF-1 levels under SRL treatment.	srls	46-50	RAR related orphan receptor C	Homo sapiens	0-4
35203668-9	2022	RORC was overexpressed in tumors treated with SRLs before surgery, and this increased expression was more prominent in those cases that normalized postsurgical IGF-1 levels under SRL treatment.	srls	46-50	insulin like growth factor 1	Homo sapiens	160-165
35203668-10	2022	In conclusion, GH-producing tumors showed a heterogeneous expression pattern of EMT-related genes that would partly explain the heterogeneous response to SRLs.	srls	154-158	growth hormone 1	Homo sapiens	15-17
35203668-11	2022	SNAI1 and RORC may be useful to predict response to SRLs and help medical treatment decision making.	srls	52-56	snail family transcriptional repressor 1	Homo sapiens	0-5
35203668-11	2022	SNAI1 and RORC may be useful to predict response to SRLs and help medical treatment decision making.	srls	52-56	RAR related orphan receptor C	Homo sapiens	10-14
32557353-4	2020	Therefore, SRLs are routinely used as medical treatment for GH-, TSH-, and ACTH-secreting pituitary tumors.	srls	11-15	proopiomelanocortin	Homo sapiens	75-79
32557353-5	2020	METHODS: Critical revision of literature data correlating SST expression with patients" response to SRLs.	srls	100-104	somatostatin	Homo sapiens	58-61
32978826-8	2021	Tumors with improved response to SRLs after surgical debulking showed lower levels of Ki-67 (MKI67, FC=0.17 and p=0.008) and higher levels of RAR related orphan receptor C (RORC) (FC=3.1 and p 0.001).	srls	33-37	marker of proliferation Ki-67	Homo sapiens	93-98
32978826-8	2021	Tumors with improved response to SRLs after surgical debulking showed lower levels of Ki-67 (MKI67, FC=0.17 and p=0.008) and higher levels of RAR related orphan receptor C (RORC) (FC=3.1 and p 0.001).	srls	33-37	RAR related orphan receptor C	Homo sapiens	142-171
32978826-8	2021	Tumors with improved response to SRLs after surgical debulking showed lower levels of Ki-67 (MKI67, FC=0.17 and p=0.008) and higher levels of RAR related orphan receptor C (RORC) (FC=3.1 and p 0.001).	srls	33-37	RAR related orphan receptor C	Homo sapiens	173-177
32609842-12	2020	CONCLUSIONS: Our study demonstrates that the normalization of IGF-1 levels during treatment with SRLs is an independent predictive factor of a favorable surgical outcome.	srls	97-101	insulin like growth factor 1	Homo sapiens	62-67