PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33979140-2	2021	Here, we have demonstrated for the first time that polyphenol oleuropein aglycone (OleA), which is the most abundant compound in olive oil, has multiple potencies for the inhibition of amyloid self-assembly of pro-inflammatory protein S100A9 and the mitigation of the damaging effect of its amyloids on neuroblastoma SH-SY5Y cells.	oleuropein	62-72	S100 calcium binding protein A9	Homo sapiens	235-241
34042426-6	2021	Oleuropein achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, the repairment islet morphology, the activation of hepatic AMP-activated protein kinase singling, and the improvement of glucose tolerance and insulin resistance.	oleuropein	0-10	insulin	Homo sapiens	96-103
34042426-6	2021	Oleuropein achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, the repairment islet morphology, the activation of hepatic AMP-activated protein kinase singling, and the improvement of glucose tolerance and insulin resistance.	oleuropein	0-10	insulin	Homo sapiens	258-265
34008118-5	2021	However, MCAO rats treated with oleuropein underwent mitigation of cerebral edema, correction of hyponatremia, remarkable decrease of plasma fibrinogen and cardiac dysfunctional enzymes, inhibition of ACE activity and improvement of oxidative stress status in brain tissue.	oleuropein	32-42	angiotensin I converting enzyme	Rattus norvegicus	201-204
33985414-7	2021	Cyclooxygenase-1 (COX-1) was significantly increased by TCDD treatment and attenuated with oleuropein pretreatment.	oleuropein	91-101	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	0-16
33985414-7	2021	Cyclooxygenase-1 (COX-1) was significantly increased by TCDD treatment and attenuated with oleuropein pretreatment.	oleuropein	91-101	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	18-23
33985414-8	2021	Oleuropein decreased TCDD-mediated production of JNK, TNF-alpha, and ROS.	oleuropein	0-10	mitogen-activated protein kinase 8	Rattus norvegicus	49-52
33985414-8	2021	Oleuropein decreased TCDD-mediated production of JNK, TNF-alpha, and ROS.	oleuropein	0-10	tumor necrosis factor	Rattus norvegicus	54-63
33389400-0	2021	Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells.	oleuropein	0-10	serpin family E member 1	Homo sapiens	37-42
33894272-8	2021	KEY FINDINGS: Upon treatment with oleuropein, the expression of P21, P53, and TNFRSF10B increased while that of Bcl-2 and Mcl1 decreased.	oleuropein	34-44	H3 histone pseudogene 16	Homo sapiens	64-67
33894272-8	2021	KEY FINDINGS: Upon treatment with oleuropein, the expression of P21, P53, and TNFRSF10B increased while that of Bcl-2 and Mcl1 decreased.	oleuropein	34-44	tumor protein p53	Homo sapiens	69-72
33894272-8	2021	KEY FINDINGS: Upon treatment with oleuropein, the expression of P21, P53, and TNFRSF10B increased while that of Bcl-2 and Mcl1 decreased.	oleuropein	34-44	TNF receptor superfamily member 10b	Homo sapiens	78-87
33894272-8	2021	KEY FINDINGS: Upon treatment with oleuropein, the expression of P21, P53, and TNFRSF10B increased while that of Bcl-2 and Mcl1 decreased.	oleuropein	34-44	BCL2 apoptosis regulator	Homo sapiens	112-117
33894272-8	2021	KEY FINDINGS: Upon treatment with oleuropein, the expression of P21, P53, and TNFRSF10B increased while that of Bcl-2 and Mcl1 decreased.	oleuropein	34-44	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	122-126
33894272-9	2021	Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells.	oleuropein	153-163	microRNA 34a	Homo sapiens	121-128
33894272-9	2021	Moreover, this is the 1st report of a significant decrease in the expression of miR-21 and increase in the expression of miR-34a, miR-125b, and miR16 by oleuropein and/or cisplatin in ovarian cancer cells.	oleuropein	153-163	glycerophosphodiester phosphodiesterase 1	Homo sapiens	144-149
33389400-5	2021	ER-/PR- (MDA-MB-231) and ER+/PR+ (MCF-7) breast cancer cell lines implemented to assess the effect of oleuropein as a natural inhibitor of PAI-1-mediated oncogenic proliferation.	oleuropein	102-112	serpin family E member 1	Homo sapiens	139-144
33389400-7	2021	By implementing an in silico molecular docking analysis, we identify oleuropein, a phenolic component of olive oil, as a potent PAI-1-binding molecule displaying increased affinity compared to the other olive oil constituents.	oleuropein	69-79	serpin family E member 1	Homo sapiens	128-133
33389400-8	2021	We demonstrate that EVOO or oleuropein treatment alone may act as a natural PAI-1 inhibitor by incrementally destabilising PAI-1 levels selectively in ER-/PR- breast cancer cells, accompanied by downstream caspase activation and cell growth inhibition.	oleuropein	28-38	serpin family E member 1	Homo sapiens	76-81
33389400-0	2021	Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells.	oleuropein	0-10	epiregulin	Homo sapiens	75-77
33389400-8	2021	We demonstrate that EVOO or oleuropein treatment alone may act as a natural PAI-1 inhibitor by incrementally destabilising PAI-1 levels selectively in ER-/PR- breast cancer cells, accompanied by downstream caspase activation and cell growth inhibition.	oleuropein	28-38	serpin family E member 1	Homo sapiens	123-128
33389400-11	2021	With a focus on breast cancer, our data identify oleuropein as a natural PAI-1 inhibitor and suggest that oleuropein-mediated PAI-1 destabilisation may confer clinical benefit only in ER-/PR- tumours.	oleuropein	49-59	serpin family E member 1	Homo sapiens	73-78
33188902-7	2021	A significant improvement of mitochondrial, proteostasis and antiviral CD8 functions was elicited by resveratrol and oleuropein.	oleuropein	117-127	CD8a molecule	Homo sapiens	71-74
33380566-6	2021	Moreover, oleuropein restored both CCI and vincristine-induced decreases in H2S, CSE, CBS, orexin, and Nrf2 levels.	oleuropein	10-20	cystathionine gamma-lyase	Rattus norvegicus	81-84
32839982-5	2021	Oleuropein was determined by the new validation method, which showed good linearity (R2  = 0.996), precision (%RSD < 10%), recovery (118.6%) and limits of detection (17.48 mg L-1 ) and quantification (21.54 mg L-1 ).	oleuropein	0-10	L1 cell adhesion molecule	Mus musculus	175-178
32839982-5	2021	Oleuropein was determined by the new validation method, which showed good linearity (R2  = 0.996), precision (%RSD < 10%), recovery (118.6%) and limits of detection (17.48 mg L-1 ) and quantification (21.54 mg L-1 ).	oleuropein	0-10	L1 cell adhesion molecule	Mus musculus	210-213
33499113-0	2021	A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-kappaB Activation.	oleuropein	20-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	156-161
33499113-0	2021	A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-kappaB Activation.	oleuropein	20-30	heme oxygenase 1	Mus musculus	162-166
33499113-0	2021	A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-kappaB Activation.	oleuropein	20-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	216-225
32041489-0	2021	Computational investigation on the effect of Oleuropein aglycone on the alpha-Synuclein aggregation.	oleuropein	45-55	synuclein alpha	Homo sapiens	72-87
32041489-4	2021	Recently, Oleuropein aglycone (OleA) has been reported to stabilize the monomeric structure of alpha-synuclein, subsequently favoring the growth of non-toxic aggregates.	oleuropein	10-20	synuclein alpha	Homo sapiens	95-110
33380566-6	2021	Moreover, oleuropein restored both CCI and vincristine-induced decreases in H2S, CSE, CBS, orexin, and Nrf2 levels.	oleuropein	10-20	cystathionine beta synthase	Rattus norvegicus	86-89
33380566-6	2021	Moreover, oleuropein restored both CCI and vincristine-induced decreases in H2S, CSE, CBS, orexin, and Nrf2 levels.	oleuropein	10-20	hypocretin neuropeptide precursor	Rattus norvegicus	91-97
33380566-6	2021	Moreover, oleuropein restored both CCI and vincristine-induced decreases in H2S, CSE, CBS, orexin, and Nrf2 levels.	oleuropein	10-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-107
33380566-8	2021	Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H2S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.	oleuropein	13-23	cystathionine gamma-lyase	Rattus norvegicus	162-165
33380566-8	2021	Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H2S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.	oleuropein	13-23	cystathionine beta synthase	Rattus norvegicus	167-170
33380566-8	2021	Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H2S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.	oleuropein	13-23	hypocretin neuropeptide precursor	Rattus norvegicus	231-237
33380566-8	2021	Conclusions: Oleuropein has therapeutic potential to attenuate the pain manifestations in CCI and vincristine-induced neuropathic pain, possibly by restoring the CSE, CBS, and H2S, which may subsequently increase the expression of orexin and Nrf2 to ameliorate behavioral manifestations of pain.	oleuropein	13-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	242-246
32710811-6	2020	OLE pretreatment significantly reduced liver damage parameters (alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase) and kidney damage parameters (blood urea nitrogen, creatinine, and kidney injury molecule-1) in the septic mice.	oleuropein	0-3	hepatitis A virus cellular receptor 1	Mus musculus	208-232
33238414-0	2020	Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway.	oleuropein	0-10	mitogen-activated protein kinase 8	Mus musculus	130-133
33238414-0	2020	Oleuropein Aglycone Peracetylated (3,4-DHPEA-EA(P)) Attenuates H2O2-Mediated Cytotoxicity in C2C12 Myocytes via Inactivation of p-JNK/p-c-Jun Signaling Pathway.	oleuropein	0-10	jun proto-oncogene	Mus musculus	136-141
33442449-23	2020	Oleuropein treatment of Huh-7 cells reduced the expression profile of PD-L1, XIST, and miR-155-5p, upregulated the expression of miR-194-5p and had no significant impact on the MALAT-1 expression profile.	oleuropein	0-10	CD274 molecule	Homo sapiens	70-75
33442449-23	2020	Oleuropein treatment of Huh-7 cells reduced the expression profile of PD-L1, XIST, and miR-155-5p, upregulated the expression of miR-194-5p and had no significant impact on the MALAT-1 expression profile.	oleuropein	0-10	X inactive specific transcript	Homo sapiens	77-81
33442449-23	2020	Oleuropein treatment of Huh-7 cells reduced the expression profile of PD-L1, XIST, and miR-155-5p, upregulated the expression of miR-194-5p and had no significant impact on the MALAT-1 expression profile.	oleuropein	0-10	microRNA 155	Homo sapiens	87-94
33096799-6	2020	Generally speaking, oleuropein and hydroxytyrosol contents enhanced with the application of 200 mg mL-1 of salicylic acid.	oleuropein	20-30	L1 cell adhesion molecule	Mus musculus	99-103
32383030-13	2020	Oleuropein administration was observed to decrease MDA, TNF-alpha, IL-6, COX-2, NF-kappaB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group.	oleuropein	0-10	tumor necrosis factor	Rattus norvegicus	56-65
32383030-13	2020	Oleuropein administration was observed to decrease MDA, TNF-alpha, IL-6, COX-2, NF-kappaB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group.	oleuropein	0-10	interleukin 6	Rattus norvegicus	67-71
32383030-13	2020	Oleuropein administration was observed to decrease MDA, TNF-alpha, IL-6, COX-2, NF-kappaB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group.	oleuropein	0-10	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	73-78
32383030-13	2020	Oleuropein administration was observed to decrease MDA, TNF-alpha, IL-6, COX-2, NF-kappaB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group.	oleuropein	0-10	troponin I3, cardiac type	Rattus norvegicus	91-94
32383030-13	2020	Oleuropein administration was observed to decrease MDA, TNF-alpha, IL-6, COX-2, NF-kappaB, TnI, CK-MB and CK levels close to the control group and to increase GSH levels and GSH-Px and CAT enzyme activities close to the control group.	oleuropein	0-10	catalase	Rattus norvegicus	185-188
31419504-6	2019	Herein, we evidenced that the reduced activity of phosphatase PTP1B after treatment with oleuropein is strictly correlated with decreased MCF-7 cellular viability and cell cycle arrest.	oleuropein	89-99	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	62-67
32656558-0	2020	Dietary oleuropein and its acyl derivative ameliorate inflammatory response in peritoneal macrophages from pristane-induced SLE mice via canonical and noncanonical NLRP3 inflammasomes pathway.	oleuropein	8-18	NLR family, pyrin domain containing 3	Mus musculus	164-169
32922228-0	2020	Oleuropein Improved Post Cerebral Stroke Cognitive Function by Promoting Histone Acetylation and Phosphorylation of cAMP Response Element-Binding Protein in MCAO Rats.	oleuropein	0-10	cAMP responsive element binding protein 1	Rattus norvegicus	116-153
33274185-8	2020	Also, downregulation of Bax and upregulation of Bcl2 were observed as a result of oleuropein treatment in comparison with untreated acetic acid induced ulcerative colitis group.	oleuropein	82-92	BCL2 associated X, apoptosis regulator	Rattus norvegicus	24-27
33274185-8	2020	Also, downregulation of Bax and upregulation of Bcl2 were observed as a result of oleuropein treatment in comparison with untreated acetic acid induced ulcerative colitis group.	oleuropein	82-92	BCL2, apoptosis regulator	Rattus norvegicus	48-52
31760852-6	2020	The PDGF-AB secretion and the soluble CD40 ligand (sCD40L) release by collagen were reduced by HT or OLE.	oleuropein	101-104	CD40 molecule	Homo sapiens	38-42
31760852-7	2020	HT and OLE significantly suppressed the phosphorylation of HSP27 and the release of phosphorylated-HSP27.	oleuropein	7-10	heat shock protein family B (small) member 1	Homo sapiens	59-64
31760852-7	2020	HT and OLE significantly suppressed the phosphorylation of HSP27 and the release of phosphorylated-HSP27.	oleuropein	7-10	heat shock protein family B (small) member 1	Homo sapiens	99-104
31795228-8	2019	Moreover, Ole regenerates when the Mix undergoes oxidation.	oleuropein	10-13	Mix paired-like homeobox	Homo sapiens	35-38
30672618-4	2019	RESULTS: The Ole-cis-DAP conjugate (i.e., C25 H36 N2 O13 PtII ) features two cis-ammine non-leaving ligands and a bidentate catechol ligand moiety belonging to Ole; the coordination of the central Pt(II) is square-planar with non-equivalent bond angles compared with the ideal arrangement of 90 .	oleuropein	13-16	death associated protein	Homo sapiens	21-24
31169033-12	2019	OL + TMZ significantly increased microRNA expression, particularly Let-7d, than OLE.	oleuropein	0-2	microRNA let-7d	Homo sapiens	67-73
31169033-13	2019	In conclusion, OL has an antitumour effect on GBM cells mainly via regulation of Let-7d expression.	oleuropein	15-17	microRNA let-7d	Homo sapiens	81-87
30618185-0	2019	Downregulation of HDAC2 and HDAC3 via oleuropein as a potent prevention and therapeutic agent in MCF-7 breast cancer cells.	oleuropein	38-48	histone deacetylase 2	Homo sapiens	18-23
30618185-0	2019	Downregulation of HDAC2 and HDAC3 via oleuropein as a potent prevention and therapeutic agent in MCF-7 breast cancer cells.	oleuropein	38-48	histone deacetylase 3	Homo sapiens	28-33
30618185-10	2019	It was found that OLE decreased the expression of both HDAC2 and HDAC3 (P < 0.05), induced apoptosis and retarded cell migration and cell invasion in a dose-dependent manner (P < 0.05).	oleuropein	18-21	histone deacetylase 2	Homo sapiens	55-60
30618185-10	2019	It was found that OLE decreased the expression of both HDAC2 and HDAC3 (P < 0.05), induced apoptosis and retarded cell migration and cell invasion in a dose-dependent manner (P < 0.05).	oleuropein	18-21	histone deacetylase 3	Homo sapiens	65-70
31755322-6	2022	The oleuropein inhibited cell apoptosis via regulation of MAPK signalling pathways and its downstream targets Bax, caspase-3, and Bcl-2 expression.Conclusion: Oleuropein may server as a favourable additional agent for the treatment of patients with DN.	oleuropein	4-14	BCL2 associated X, apoptosis regulator	Homo sapiens	110-113
31755322-6	2022	The oleuropein inhibited cell apoptosis via regulation of MAPK signalling pathways and its downstream targets Bax, caspase-3, and Bcl-2 expression.Conclusion: Oleuropein may server as a favourable additional agent for the treatment of patients with DN.	oleuropein	4-14	caspase 3	Homo sapiens	115-124
31755322-6	2022	The oleuropein inhibited cell apoptosis via regulation of MAPK signalling pathways and its downstream targets Bax, caspase-3, and Bcl-2 expression.Conclusion: Oleuropein may server as a favourable additional agent for the treatment of patients with DN.	oleuropein	4-14	BCL2 apoptosis regulator	Homo sapiens	130-135
31755322-6	2022	The oleuropein inhibited cell apoptosis via regulation of MAPK signalling pathways and its downstream targets Bax, caspase-3, and Bcl-2 expression.Conclusion: Oleuropein may server as a favourable additional agent for the treatment of patients with DN.	oleuropein	159-169	BCL2 associated X, apoptosis regulator	Homo sapiens	110-113
31755322-6	2022	The oleuropein inhibited cell apoptosis via regulation of MAPK signalling pathways and its downstream targets Bax, caspase-3, and Bcl-2 expression.Conclusion: Oleuropein may server as a favourable additional agent for the treatment of patients with DN.	oleuropein	159-169	caspase 3	Homo sapiens	115-124
31755322-6	2022	The oleuropein inhibited cell apoptosis via regulation of MAPK signalling pathways and its downstream targets Bax, caspase-3, and Bcl-2 expression.Conclusion: Oleuropein may server as a favourable additional agent for the treatment of patients with DN.	oleuropein	159-169	BCL2 apoptosis regulator	Homo sapiens	130-135
30317622-7	2019	The results showed that migration ability of MCF-7 cells remarkably decreased in OLEU treated group and RT-PCR results showed that OLEU may exert its antimigratory action by suppressing EMT through downregulation of sirtuin1 (SIRT1).	oleuropein	131-135	sirtuin 1	Homo sapiens	216-224
30317622-7	2019	The results showed that migration ability of MCF-7 cells remarkably decreased in OLEU treated group and RT-PCR results showed that OLEU may exert its antimigratory action by suppressing EMT through downregulation of sirtuin1 (SIRT1).	oleuropein	131-135	sirtuin 1	Homo sapiens	226-231
30317622-9	2019	This study provides evidence regarding the suppressive role of OLEU on MCF-7 cells migration ability through suppression of EMT, and for the first time, it was proposed that SIRT1 downregulation can be involved in the OLEU antimigratory effect.	oleuropein	218-222	sirtuin 1	Homo sapiens	174-179
30672618-6	2019	CONCLUSIONS: The first evidence, together with structural information, is provided about the in vitro formation of a conjugate between cis-DAP and Ole or its urinary metabolite HT.	oleuropein	147-150	death associated protein	Homo sapiens	139-142
28420140-10	2017	Histologically, OLE-treated colonic samples showed an amelioration of inflammatory damage with reduced infiltration of CD3, CD4, and CD20 cells, while CD68 numbers increased.	oleuropein	16-19	CD4 molecule	Homo sapiens	124-127
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	interleukin 1 beta	Homo sapiens	45-53
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	nitric oxide synthase 2	Homo sapiens	110-114
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	matrix metallopeptidase 1	Homo sapiens	116-121
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	matrix metallopeptidase 13	Homo sapiens	123-129
28952621-8	2017	We found that OL significantly inhibited the IL-1beta-induced production of NO and PGE2; expression of COX-2, iNOS, MMP-1, MMP-13, and ADAMTS-5; and degradation of aggrecan and collagen-II.	oleuropein	14-16	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	135-143
28525856-10	2017	Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats.	oleuropein	10-13	tumor necrosis factor	Rattus norvegicus	121-145
28525856-10	2017	Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats.	oleuropein	10-13	tumor necrosis factor	Rattus norvegicus	147-152
28525856-10	2017	Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats.	oleuropein	10-13	interleukin 1 beta	Rattus norvegicus	155-172
28525856-10	2017	Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats.	oleuropein	10-13	interleukin 1 beta	Rattus norvegicus	174-182
28525856-10	2017	Moreover, OLE inhibited CD4+, CD8+ cells and macrophage infiltration in myocardium and decreased the serum production of tumour necrosis factor-a (TNF-a), interleukin-1beta (IL-1beta) and IL-6 in EAM rats.	oleuropein	10-13	interleukin 6	Rattus norvegicus	188-192
28525856-12	2017	Furthermore, OLE decreased the myocardial expressions of phosphorylated-p38 MAPK, phosphorylated-ERK, and did not change the levels of p38 MAPK and ERK in EAM rats.	oleuropein	13-16	mitogen activated protein kinase 14	Rattus norvegicus	72-75
28525856-12	2017	Furthermore, OLE decreased the myocardial expressions of phosphorylated-p38 MAPK, phosphorylated-ERK, and did not change the levels of p38 MAPK and ERK in EAM rats.	oleuropein	13-16	Eph receptor B1	Rattus norvegicus	97-100
30544824-6	2018	Our work reveals the ability of Ole to induce, in liver of ND and HFD mice, autophagy independently by gender-specific mTOR activation.	oleuropein	32-35	mechanistic target of rapamycin kinase	Mus musculus	119-123
29960113-0	2018	The olive constituent oleuropein, as a PPARalpha agonist, markedly reduces serum triglycerides.	oleuropein	22-32	peroxisome proliferator activated receptor alpha	Mus musculus	39-48
30460087-8	2018	OLE also blocked the SPS-induced decrease in hippocampal serotonin and neuropeptide Y expression in hippocampus.	oleuropein	0-3	neuropeptide Y	Rattus norvegicus	71-85
28410190-8	2017	OL suppressed HFD-induced increases in lymph node (LN) metastasis; expression of VEGF-A, VEGF-C, and VEGF-D in the LN; and M2-MPhis and the size of adipocytes in adipose tissues surrounding LNs.	oleuropein	0-2	vascular endothelial growth factor A	Mus musculus	81-87
28410190-8	2017	OL suppressed HFD-induced increases in lymph node (LN) metastasis; expression of VEGF-A, VEGF-C, and VEGF-D in the LN; and M2-MPhis and the size of adipocytes in adipose tissues surrounding LNs.	oleuropein	0-2	vascular endothelial growth factor C	Mus musculus	89-95
28410190-8	2017	OL suppressed HFD-induced increases in lymph node (LN) metastasis; expression of VEGF-A, VEGF-C, and VEGF-D in the LN; and M2-MPhis and the size of adipocytes in adipose tissues surrounding LNs.	oleuropein	0-2	vascular endothelial growth factor D	Mus musculus	101-107
28410190-11	2017	The overall results indicated that dietary OL inhibits lipid and M2-MPhi accumulation in HFD-fed mice, which contributes to decreases in VEGF secretion, thereby leading to inhibition of angiogenesis and lymphangiogenesis.	oleuropein	43-45	vascular endothelial growth factor A	Mus musculus	137-141
28420140-10	2017	Histologically, OLE-treated colonic samples showed an amelioration of inflammatory damage with reduced infiltration of CD3, CD4, and CD20 cells, while CD68 numbers increased.	oleuropein	16-19	keratin 20	Homo sapiens	133-137
28420140-10	2017	Histologically, OLE-treated colonic samples showed an amelioration of inflammatory damage with reduced infiltration of CD3, CD4, and CD20 cells, while CD68 numbers increased.	oleuropein	16-19	CD68 molecule	Homo sapiens	151-155
28057028-9	2017	Overexpression of HIF1alpha or PDRG1, and downregulation of miR-519d abolished the radiation sensitizing effects of OL.	oleuropein	116-118	hypoxia inducible factor 1, alpha subunit	Mus musculus	18-27
28105567-8	2017	On the other hand, the anticonvulsant effect of oleuropein (10 mg/kg) was blocked by a non-effective dose of nonspecific inhibitor of nitric oxide synthase (NOS), L-NAME (1 and 10 mg/kg, i.p) and a selective inhibitor of neuronal NOS, 7-nitroindazole (30 mg/kg, i.p.).	oleuropein	48-58	nitric oxide synthase 1, neuronal	Mus musculus	134-155
27847271-7	2017	Furthermore, the phase II enzyme levels of Nrf2 and its downstream proteins NQO-1 and HO-1 were all markedly increased in the PVN of the OL-treated SHR group compared with the saline-treated SHR rats.	oleuropein	137-139	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-47
27847271-7	2017	Furthermore, the phase II enzyme levels of Nrf2 and its downstream proteins NQO-1 and HO-1 were all markedly increased in the PVN of the OL-treated SHR group compared with the saline-treated SHR rats.	oleuropein	137-139	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	76-81
27847271-7	2017	Furthermore, the phase II enzyme levels of Nrf2 and its downstream proteins NQO-1 and HO-1 were all markedly increased in the PVN of the OL-treated SHR group compared with the saline-treated SHR rats.	oleuropein	137-139	heme oxygenase 1	Rattus norvegicus	86-90
27847271-8	2017	Our findings demonstrate that OL administration can protect the PVN of the hypothalamus from oxidative stress by improving mitochondrial function through the activation of the Nrf2-mediated signaling pathway.	oleuropein	30-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	176-180
28057028-11	2017	OL treatment reduces the activity of HIF1alpha-miR-519d-PDRG1 pathway, which is essential to the radiosensitizing effects of OL.	oleuropein	0-2	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-46
28057028-11	2017	OL treatment reduces the activity of HIF1alpha-miR-519d-PDRG1 pathway, which is essential to the radiosensitizing effects of OL.	oleuropein	0-2	p53 and DNA damage regulated 1	Mus musculus	56-61
28057028-11	2017	OL treatment reduces the activity of HIF1alpha-miR-519d-PDRG1 pathway, which is essential to the radiosensitizing effects of OL.	oleuropein	125-127	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-46
28057028-11	2017	OL treatment reduces the activity of HIF1alpha-miR-519d-PDRG1 pathway, which is essential to the radiosensitizing effects of OL.	oleuropein	125-127	p53 and DNA damage regulated 1	Mus musculus	56-61
33798547-4	2021	This study aimed to verify the cytotoxic effect of oleuropein on MDA-MB-231 cell line and to unravel novel ceRNA interaction between miR-194-5p and XIST in breast cancer and their immunomodulatory effect on PD-L1 expression to propose a promising prophylactic and preventive role of Oleuropin in diet.	oleuropein	51-61	X inactive specific transcript	Homo sapiens	148-152
27914828-9	2017	Further studies showed that OL also inhibited H2O2-induced P38 and JNK phosphorylation but enhanced ERK1/2 phosphorylation in a dose-dependent manner.	oleuropein	28-30	mitogen-activated protein kinase 1	Homo sapiens	59-62
27914828-9	2017	Further studies showed that OL also inhibited H2O2-induced P38 and JNK phosphorylation but enhanced ERK1/2 phosphorylation in a dose-dependent manner.	oleuropein	28-30	mitogen-activated protein kinase 8	Homo sapiens	67-70
27914828-9	2017	Further studies showed that OL also inhibited H2O2-induced P38 and JNK phosphorylation but enhanced ERK1/2 phosphorylation in a dose-dependent manner.	oleuropein	28-30	mitogen-activated protein kinase 3	Homo sapiens	100-106
23368925-11	2013	Our novel findings demonstrate that OL limits the growth and induces apoptosis in HT-29 cells via p53 pathway activation adapting the HIF-1alpha response to hypoxia.	oleuropein	36-38	tumor protein p53	Homo sapiens	98-101
23368925-11	2013	Our novel findings demonstrate that OL limits the growth and induces apoptosis in HT-29 cells via p53 pathway activation adapting the HIF-1alpha response to hypoxia.	oleuropein	36-38	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
33798547-9	2021	Oleuropein showed anti-carcinogenic impact by decreasing miR-194 and PD-L1 levels while increasing XIST level.	oleuropein	0-10	CD274 molecule	Homo sapiens	69-74
33798547-9	2021	Oleuropein showed anti-carcinogenic impact by decreasing miR-194 and PD-L1 levels while increasing XIST level.	oleuropein	0-10	X inactive specific transcript	Homo sapiens	99-103
27540349-6	2016	Treatments with CF, DHA and OL significantly incremented lipolysis in P20 cells in comparison to other compounds and in CTRL cells.	oleuropein	28-30	tubulin polymerization promoting protein family member 3	Homo sapiens	70-73
21053258-3	2011	In this study, the interaction of two antioxidants, oleuropein (OE) and melatonin (M), with Abeta is monitored through nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry.	oleuropein	52-62	amyloid beta precursor protein	Homo sapiens	92-97
21053258-3	2011	In this study, the interaction of two antioxidants, oleuropein (OE) and melatonin (M), with Abeta is monitored through nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry.	oleuropein	64-66	amyloid beta precursor protein	Homo sapiens	92-97
34162688-6	2021	Activation of the PI3k/AKT/FOX01, JNK, AKT/p70 and ERK related pathways participates in CYP induction by OLE.	oleuropein	105-108	thymoma viral proto-oncogene 1	Mus musculus	23-26
34613549-0	2022	Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1beta-Induced Inflammation by Blocking MAPK/NF-kappaB Signaling Pathways.	oleuropein	0-10	interleukin 1 alpha	Homo sapiens	64-72
34613549-0	2022	Oleuropein Protects Human Retinal Pigment Epithelium Cells from IL-1beta-Induced Inflammation by Blocking MAPK/NF-kappaB Signaling Pathways.	oleuropein	0-10	nuclear factor kappa B subunit 1	Homo sapiens	111-120
34613549-6	2022	To clarify the underlying anti-inflammatory mechanisms, we used western blots to evaluate the effect of oleuropein on inactivation of the nuclear factor-kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	oleuropein	104-114	nuclear factor kappa B subunit 1	Homo sapiens	138-160
34613549-6	2022	To clarify the underlying anti-inflammatory mechanisms, we used western blots to evaluate the effect of oleuropein on inactivation of the nuclear factor-kappa B (NF-kappaB) and mitogen-activated protein kinase (MAPK) signaling pathways.	oleuropein	104-114	nuclear factor kappa B subunit 1	Homo sapiens	162-171
34613549-7	2022	The results showed that oleuropein significantly decreased levels of the inflammatory mediator cyclooxygenase-2 and increased anti-inflammatory protein HO-1 expression.	oleuropein	24-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-111
34613549-7	2022	The results showed that oleuropein significantly decreased levels of the inflammatory mediator cyclooxygenase-2 and increased anti-inflammatory protein HO-1 expression.	oleuropein	24-34	heme oxygenase 1	Homo sapiens	152-156
34613549-9	2022	We found that suppressing phosphorylation of the JNK1/2 and p38 MAPK signaling pathways inhibited IL-6, MCP-1, and sICAM-1 secretion, implicating these pathways and NF-kappaB suppression in the effects of oleuropein.	oleuropein	205-215	mitogen-activated protein kinase 8	Homo sapiens	49-55
34613549-9	2022	We found that suppressing phosphorylation of the JNK1/2 and p38 MAPK signaling pathways inhibited IL-6, MCP-1, and sICAM-1 secretion, implicating these pathways and NF-kappaB suppression in the effects of oleuropein.	oleuropein	205-215	interleukin 6	Homo sapiens	98-102
34613549-9	2022	We found that suppressing phosphorylation of the JNK1/2 and p38 MAPK signaling pathways inhibited IL-6, MCP-1, and sICAM-1 secretion, implicating these pathways and NF-kappaB suppression in the effects of oleuropein.	oleuropein	205-215	C-C motif chemokine ligand 2	Homo sapiens	104-109
34613549-9	2022	We found that suppressing phosphorylation of the JNK1/2 and p38 MAPK signaling pathways inhibited IL-6, MCP-1, and sICAM-1 secretion, implicating these pathways and NF-kappaB suppression in the effects of oleuropein.	oleuropein	205-215	nuclear factor kappa B subunit 1	Homo sapiens	165-174
34829568-0	2021	Oleuropein Enhances Stress Resistance and Extends Lifespan via Insulin/IGF-1 and SKN-1/Nrf2 Signaling Pathway in Caenorhabditis elegans.	oleuropein	0-10	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	81-86
34126350-10	2021	Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated IL-6 release.	oleuropein	19-29	tumor necrosis factor	Mus musculus	45-54
34126350-10	2021	Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated IL-6 release.	oleuropein	19-29	interleukin 6	Mus musculus	66-70
34126350-13	2021	CONCLUSION: Our present findings strongly suggest that olive oil polyphenols hydroxytyrosol and oleuropein down-regulates TNF-alpha signaling at the points upstream of Akt and p44/p42 MAP kinase in osteoblasts, leading to the attenuation of M-CSF and IL-6 synthesis.	oleuropein	96-106	tumor necrosis factor	Mus musculus	122-131
34126350-13	2021	CONCLUSION: Our present findings strongly suggest that olive oil polyphenols hydroxytyrosol and oleuropein down-regulates TNF-alpha signaling at the points upstream of Akt and p44/p42 MAP kinase in osteoblasts, leading to the attenuation of M-CSF and IL-6 synthesis.	oleuropein	96-106	thymoma viral proto-oncogene 1	Mus musculus	168-171
34126350-13	2021	CONCLUSION: Our present findings strongly suggest that olive oil polyphenols hydroxytyrosol and oleuropein down-regulates TNF-alpha signaling at the points upstream of Akt and p44/p42 MAP kinase in osteoblasts, leading to the attenuation of M-CSF and IL-6 synthesis.	oleuropein	96-106	mitogen-activated protein kinase 3	Mus musculus	176-179
34126350-13	2021	CONCLUSION: Our present findings strongly suggest that olive oil polyphenols hydroxytyrosol and oleuropein down-regulates TNF-alpha signaling at the points upstream of Akt and p44/p42 MAP kinase in osteoblasts, leading to the attenuation of M-CSF and IL-6 synthesis.	oleuropein	96-106	cyclin-dependent kinase 20	Mus musculus	180-183
34126350-13	2021	CONCLUSION: Our present findings strongly suggest that olive oil polyphenols hydroxytyrosol and oleuropein down-regulates TNF-alpha signaling at the points upstream of Akt and p44/p42 MAP kinase in osteoblasts, leading to the attenuation of M-CSF and IL-6 synthesis.	oleuropein	96-106	colony stimulating factor 1 (macrophage)	Mus musculus	241-246
34126350-13	2021	CONCLUSION: Our present findings strongly suggest that olive oil polyphenols hydroxytyrosol and oleuropein down-regulates TNF-alpha signaling at the points upstream of Akt and p44/p42 MAP kinase in osteoblasts, leading to the attenuation of M-CSF and IL-6 synthesis.	oleuropein	96-106	interleukin 6	Mus musculus	251-255
34126350-2	2021	The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts.	oleuropein	102-112	tumor necrosis factor	Mus musculus	149-158
34126350-2	2021	The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts.	oleuropein	102-112	colony stimulating factor 1 (macrophage)	Mus musculus	206-211
34126350-2	2021	The aim of this study is to elucidate the effects and the underlying mechanisms of hydroxytyrosol and oleuropein on the tumor necrosis factor-alpha (TNF-alpha)-induced macrophage colony-stimulating factor (M-CSF) and interleukin-6 (IL-6) synthesis in osteoblasts.	oleuropein	102-112	interleukin 6	Mus musculus	232-236
34126350-7	2021	RESULTS: Hydroxytyrosol and oleuropein attenuated the TNF-alpha-stimulated M-CSF release.	oleuropein	28-38	colony stimulating factor 1 (macrophage)	Mus musculus	75-80
34126350-9	2021	Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase.	oleuropein	19-29	tumor necrosis factor	Mus musculus	45-54
34126350-9	2021	Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase.	oleuropein	19-29	thymoma viral proto-oncogene 1	Mus musculus	82-85
34126350-9	2021	Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase.	oleuropein	19-29	mitogen-activated protein kinase 3	Mus musculus	90-93
34126350-9	2021	Hydroxytyrosol and oleuropein suppressed the TNF-alpha-induced phosphorylation of Akt and p44/p42 MAP kinase.	oleuropein	19-29	cyclin-dependent kinase 20	Mus musculus	94-97
34162688-6	2021	Activation of the PI3k/AKT/FOX01, JNK, AKT/p70 and ERK related pathways participates in CYP induction by OLE.	oleuropein	105-108	mitogen-activated protein kinase 8	Mus musculus	34-37
34162688-6	2021	Activation of the PI3k/AKT/FOX01, JNK, AKT/p70 and ERK related pathways participates in CYP induction by OLE.	oleuropein	105-108	thymoma viral proto-oncogene 1	Mus musculus	39-42
34162688-6	2021	Activation of the PI3k/AKT/FOX01, JNK, AKT/p70 and ERK related pathways participates in CYP induction by OLE.	oleuropein	105-108	interleukin 2 receptor, beta chain	Mus musculus	43-46
34162688-6	2021	Activation of the PI3k/AKT/FOX01, JNK, AKT/p70 and ERK related pathways participates in CYP induction by OLE.	oleuropein	105-108	mitogen-activated protein kinase 1	Mus musculus	51-54
34162688-6	2021	Activation of the PI3k/AKT/FOX01, JNK, AKT/p70 and ERK related pathways participates in CYP induction by OLE.	oleuropein	105-108	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	88-91
34162688-8	2021	Therefore, OLE-induced activation of PPARalpha could modify the effects of drugs due to their increased metabolism and clearance, which should be taken into account when consuming OLE-containing products with certain drugs, in particular those of narrow therapeutic window.	oleuropein	11-14	peroxisome proliferator activated receptor alpha	Mus musculus	37-46
34162688-9	2021	Significance Statement This study indicated that oleuropein, which belongs to the main constituents of the leaves and olive drupes of Olea europaea, induces the synthesis of the major CYPs metabolizing the majority of prescribed drugs via activation of PPARalpha.	oleuropein	49-59	peroxisome proliferator activated receptor alpha	Mus musculus	253-262
34356366-5	2021	Oleuropein, oleacein, oleocanthal, hydroxytyrosol, and tyrosol, tested alone, reduced the DPP-IV activity, with IC50 of 472.3 +- 21.7, 187 +- 11.4, 354.5 +- 12.7, 741.6 +- 35.7, and 1112 +- 55.6 microM, respectively.	oleuropein	0-10	dipeptidyl peptidase 4	Homo sapiens	90-96
34496482-10	2021	Results: Oleuropein could reduce DNA damage and serum TNF-alpha and IL-6 levels.	oleuropein	9-19	tumor necrosis factor	Rattus norvegicus	54-63
34496482-10	2021	Results: Oleuropein could reduce DNA damage and serum TNF-alpha and IL-6 levels.	oleuropein	9-19	interleukin 6	Rattus norvegicus	68-72
35528541-0	2022	Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway.	oleuropein	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
34062923-0	2021	Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway.	oleuropein	81-91	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
34062923-0	2021	Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway.	oleuropein	81-91	glyoxalase I	Homo sapiens	137-141
34628790-0	2021	Brain-derived neurotrophic factor enhances the therapeutic effect of oleuropein in the lipopolysaccharide-induced models of depression.	oleuropein	69-79	brain derived neurotrophic factor	Homo sapiens	0-33
35532254-7	2022	Importantly is to mention that Curcumin, Proanthocyanidin B2, Oleocanthal, Oleuropein Aglycone, Thionine, Resveratrol had been reported as direct inhibitors of tau.	oleuropein	75-85	microtubule associated protein tau	Homo sapiens	160-163
35528541-0	2022	Oleuropein Improves Cognitive Dysfunction and Neuroinflammation in Diabetic Rats through the PI3K/Akt/mTOR Pathway.	oleuropein	0-10	mechanistic target of rapamycin kinase	Rattus norvegicus	102-106
35528541-8	2022	Conclusion: Oleuropein ameliorates cognitive dysfunction and neuroinflammation in diabetic rats by regulating the PI3K/Akt/mTOR signaling pathway.	oleuropein	12-22	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
35528541-8	2022	Conclusion: Oleuropein ameliorates cognitive dysfunction and neuroinflammation in diabetic rats by regulating the PI3K/Akt/mTOR signaling pathway.	oleuropein	12-22	mechanistic target of rapamycin kinase	Rattus norvegicus	123-127
35077933-10	2022	Based on the ADMET and molecular docking data, the hERG inhibitory activities of verbascoside, oleuropein, and hydroxytyrosol were investigated using patch clamp assays and they were identified as non-inhibitors.	oleuropein	95-105	ETS transcription factor ERG	Homo sapiens	51-55
35330101-6	2022	Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively.	oleuropein	83-93	transformed mouse 3T3 cell double minute 2	Mus musculus	0-22
35330101-6	2022	Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively.	oleuropein	83-93	transformed mouse 3T3 cell double minute 2	Mus musculus	24-28
35168092-11	2022	The CMC identified phenol glycosides, including salidroside and oleuropein, which increased intracellular calcium content, promoted expression of PTH1R and TRPV5 and ratio of p-PKA/PKA as well as decreased calcium excretion in urine of mice fed with high calcium diet.	oleuropein	64-74	parathyroid hormone 1 receptor	Mus musculus	146-151
35168092-11	2022	The CMC identified phenol glycosides, including salidroside and oleuropein, which increased intracellular calcium content, promoted expression of PTH1R and TRPV5 and ratio of p-PKA/PKA as well as decreased calcium excretion in urine of mice fed with high calcium diet.	oleuropein	64-74	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	156-161
35168092-12	2022	CONCLUSION: Salidroside and oleuropein are major ingredients contributing to the anti-hypercalciuria effects of FLL via acting on PTH1R/PKA/TRPV5 signaling in kidney.	oleuropein	28-38	parathyroid hormone 1 receptor	Mus musculus	130-135
35168092-12	2022	CONCLUSION: Salidroside and oleuropein are major ingredients contributing to the anti-hypercalciuria effects of FLL via acting on PTH1R/PKA/TRPV5 signaling in kidney.	oleuropein	28-38	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	140-145
35410513-4	2022	In this study, the potential effects of OLEU in shifting CD4+ T cells toward Tregs are evaluated in patients with RA.	oleuropein	40-44	CD4 molecule	Homo sapiens	57-60
35410513-9	2022	RESULTS: OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs (p = 0.0001).	oleuropein	9-13	CD4 molecule	Homo sapiens	49-52
35410513-9	2022	RESULTS: OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs (p = 0.0001).	oleuropein	9-13	CD4 molecule	Homo sapiens	94-97
35410513-9	2022	RESULTS: OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs (p = 0.0001).	oleuropein	9-13	interleukin 2 receptor subunit alpha	Homo sapiens	98-102
35410513-9	2022	RESULTS: OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs (p = 0.0001).	oleuropein	9-13	forkhead box P3	Homo sapiens	105-110