PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34818736-4	2022	Regression analysis in the range from 0.001 to 100 ng mL-1 showed the limit of detection (LOD) being 0.6 pg mL-1 in standard solution, indicating that the great prospects of the AuNP dimers/MXenes SERS substrate for detecting AFB1.	aunp	178-182	2'-5' oligoadenylate synthetase 1B	Mus musculus	54-58
34818736-4	2022	Regression analysis in the range from 0.001 to 100 ng mL-1 showed the limit of detection (LOD) being 0.6 pg mL-1 in standard solution, indicating that the great prospects of the AuNP dimers/MXenes SERS substrate for detecting AFB1.	aunp	178-182	2'-5' oligoadenylate synthetase 1B	Mus musculus	108-112
34871833-2	2022	The biosensor was fabricated by immobilizing a GzmB monoclonal antibody (Ab1) on a poly3"-(2-aminopyrimidyl)-2,2":5",2""-terthiophene/gold nanoparticle (pPATT/AuNP) layer.	aunp	159-163	granzyme B	Homo sapiens	47-51
34801899-4	2022	The binding of gold nanoparticles (AuNPs) onto silica microparticles (SPs) resulting from the strong hybridization of 20 bps induces an increase in the density of SPs, leading to an increase in Fac and Fsed; consequently, the voltage V required for dissociation becomes lower than that required without AuNP binding.	aunp	303-307	FA complementation group C	Homo sapiens	194-197
34229822-4	2021	Compared with that in the control group, GSK-3beta expression in AuNP-dexmedetomidine groups increased (P < 0.05).	aunp	65-69	glycogen synthase kinase 3 alpha	Rattus norvegicus	41-50
34229822-5	2021	The protein expression of GSK-3beta was higher and mRNA expression was significantly lower in the 100 mug/kg AuNP-dexmedetomidine group (P < 0.05).	aunp	109-113	glycogen synthase kinase 3 alpha	Rattus norvegicus	26-35
34834381-7	2021	Cargo-devoid apoferritin is poorly internalized in all cell lines, and the highest ferritin uptake was achieved with AuNP-loaded H-ferritin homopolymers in transferrin-receptor-rich cell lines, showing more than seven times more uptake than apoferritin.	aunp	117-121	ferritin heavy chain 1	Homo sapiens	13-24
34834381-7	2021	Cargo-devoid apoferritin is poorly internalized in all cell lines, and the highest ferritin uptake was achieved with AuNP-loaded H-ferritin homopolymers in transferrin-receptor-rich cell lines, showing more than seven times more uptake than apoferritin.	aunp	117-121	transferrin	Homo sapiens	156-167
34098358-0	2021	SPR/SERS dual-mode plasmonic biosensor via catalytic hairpin assembly-induced AuNP network.	aunp	78-82	sepiapterin reductase	Homo sapiens	0-3
34331134-6	2021	On this basis, we developed a method for the detection of human carboxylesterase 1 (hCE 1) in human serum using AuNP/AE-MIL-101 (Cr) nanocomposite as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as SERS marker.	aunp	112-116	carboxylesterase 1	Homo sapiens	64-82
34331134-10	2021	By using AuNP/acid etching-MIL-101(Cr) metal organic framework (MOF) as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as the SERS marker, a rapid and sensitive method for the determination of human carboxylesterase 1 (hCE1) in human serum samples has been developed.	aunp	9-13	carboxylesterase 1	Homo sapiens	236-254
34331134-10	2021	By using AuNP/acid etching-MIL-101(Cr) metal organic framework (MOF) as SERS substrate and enzyme-linked immunosorbent assay (ELISA) colorimetric substrate as the SERS marker, a rapid and sensitive method for the determination of human carboxylesterase 1 (hCE1) in human serum samples has been developed.	aunp	9-13	carboxylesterase 1	Homo sapiens	256-260
34825014-13	2021	According to the presented result, it may be concluded that by scavenging of free superoxide radicals in the presence of SOD, the amount of AuNP absorbance can be replenished.	aunp	140-144	superoxide dismutase 1	Homo sapiens	121-124
34541385-2	2022	Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin (Lf) and lactoferrin receptor (LfR) that is highly expressed in the intestine, blood-brain barrier and GBM.	aunp	55-59	intelectin 1	Homo sapiens	162-182
34541385-2	2022	Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin (Lf) and lactoferrin receptor (LfR) that is highly expressed in the intestine, blood-brain barrier and GBM.	aunp	55-59	intelectin 1	Homo sapiens	184-187
35202985-6	2022	LFI sensing using PLASCOP AuNP clusters composed of 40 nm AuNPs showed a high detection sensitivity for SARS-CoV-2 nucleocapsid proteins with a limit of detection (LOD) of 0.038 ng mL-1, which was 23.8- and 5.9-times lower value than that of single 15 nm and 40 nm AuNP conjugates, respectively.	aunp	265-269	L1 cell adhesion molecule	Mus musculus	181-185
35499716-8	2022	Treatment with AuNP significantly lowered the blood glucose level, the gene expression, and the activity of hepatic PEPCK in comparison to the diabetic untreated group (P < 0.05).	aunp	15-19	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	116-121
34986278-8	2022	Subsequent AuNP binding was highly selective on the ntagCyseADF4(k16) side demonstrating the potential of such silk-based systems to realize complex bifunctional structures with spatial resolutions in the nano scale.	aunp	11-15	keratin 16	Homo sapiens	52-68
34983539-7	2022	PEGylated-lactoferrin (Lf-PEG) was incorporated onto the AuNP surface for both oral absorption and GBM targeting of the nanoconjugate (denoted as Ce6-AuNP-Lf).	aunp	57-61	lactotransferrin	Mus musculus	10-21
34983543-2	2022	The low figure of merit (FoM) of the LSPR and high-concentration AuNP requirement restrict their limit of detection (LOD), which is approximately ng to mug mL-1 in antibody detection if there is no other signal or analyte amplification.	aunp	65-69	L1 cell adhesion molecule	Mus musculus	156-160
34048512-2	2021	This paper describes the fabrication of an MMP-1 immunosensor based on a gold nanoparticle/polyethyleneimine/reduced graphene oxide (AuNP/PEI/rGO)-modified disposable screen-printed electrode (SPE).	aunp	133-137	matrix metallopeptidase 1	Homo sapiens	43-48
34023865-3	2021	To improve the photoelectric conversion efficiency of the Yb-MOF in the NIR region, the surface of the Yb-MOF was integrated with gold nanoparticles (AuNPs) to fabricate a Yb-MOF@AuNP nanocomposite through an in situ reduction of chloroauric acid with sodium borohydride.	aunp	150-154	lysine acetyltransferase 8	Homo sapiens	106-109
34023865-3	2021	To improve the photoelectric conversion efficiency of the Yb-MOF in the NIR region, the surface of the Yb-MOF was integrated with gold nanoparticles (AuNPs) to fabricate a Yb-MOF@AuNP nanocomposite through an in situ reduction of chloroauric acid with sodium borohydride.	aunp	150-154	lysine acetyltransferase 8	Homo sapiens	106-109
33998609-3	2021	In this work, we developed a nano-capturer Fe3O4@SiO2-NTA with an enhanced signal by taking advantage of a AuNP-anti-IgE nanobioprobe for precise and highly sensitive quantification detection of sIgE in serum of allergic patients.	aunp	107-111	immunoglobulin heavy constant epsilon	Homo sapiens	117-120
33881108-4	2021	Supramolecule-mediated AuNP composites (GNCs) were modified on the gold electrode as a sensing film to capture anti-nitrated alpha-syn.	aunp	23-27	synuclein alpha	Homo sapiens	125-134
33592729-4	2021	Here, a biosensor CPs/AuNP-AuE, the gold nanoparticle (AuNP)-modified Au electrode (AuE) which was coupled with DNA capture probes (CPs), was developed to detect the content of miR-100 in the sera of GC patients.	aunp	22-26	microRNA 100	Homo sapiens	177-184
33672227-2	2021	Herein, upon analyzing the Au 4f core-level spin-orbit components in many as-synthesized AuNP-based catalysts, we observed that like deviations in the Au 4f7/2 binding energy positions, both the Au 4f7/2-to-Au 4f5/2 peak intensity and linewidth ratios varied largely from the standard statistical bulk reference values.	aunp	89-93	spindlin 1	Homo sapiens	44-48
33468677-2	2021	Enzyme activity is accelerated by pulsed-laser excitation when the AuNP is attached close to a network of coupled motions in DHFR (on the FG loop, containing residues 116-132, or on a nearby alpha helix).	aunp	67-71	dihydrofolate reductase	Homo sapiens	125-129
33076071-4	2021	Taking advantage of the localized surface plasmon resonance (LSPR) effect along with good conductivity of AuNPs, the developed AuNP/Ag2S/fluorine-doped tin oxide (FTO) owns much higher photoelectric conversion efficiency, and the photocurrent is 5.3 times that of Ag2S FTO.	aunp	106-110	angiotensin II receptor type 1	Homo sapiens	132-136
33226391-1	2020	This work demonstrated the development of conducting poly(chrysoidine G) (PCG)-gold nanoparticle (AuNP)-modified fluorine-doped tin oxide (F : SnO2, FTO) film-coated glass electrodes for the sensitive electrochemical detection of nitrite (NO2-).	aunp	98-102	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	149-152
32919636-8	2020	Our studies demonstrate that LP coated AuNP can be used as an effective platform to selectively target SSTR2 positive cancer cells for combination therapy approaches involving gold nanoparticles.	aunp	39-43	somatostatin receptor 2	Rattus norvegicus	103-108
33179397-3	2020	Of note, when the AuNBPs motor/AuNP probe enters into cells, miR-21 triggers the reaction between AuNBPs motor and AuNP probe, resulting in the formation of CS nanostructure assembly.	aunp	31-35	microRNA 21	Homo sapiens	61-67
33179397-3	2020	Of note, when the AuNBPs motor/AuNP probe enters into cells, miR-21 triggers the reaction between AuNBPs motor and AuNP probe, resulting in the formation of CS nanostructure assembly.	aunp	115-119	microRNA 21	Homo sapiens	61-67
33104346-3	2020	Therefore, we hypothesize that the formation of PC around AuNPs could inevitably affect the AuNP-based target assay.	aunp	58-62	pyruvate carboxylase	Homo sapiens	48-50
32761361-2	2020	First, MUC16 antibody was adsorbed onto the surface of the Au nanoparticle (AuNP)-modified indium tin oxide (ITO) electrode to effectively capture the target MUC16.	aunp	76-80	mucin 16, cell surface associated	Homo sapiens	7-12
32761361-2	2020	First, MUC16 antibody was adsorbed onto the surface of the Au nanoparticle (AuNP)-modified indium tin oxide (ITO) electrode to effectively capture the target MUC16.	aunp	76-80	mucin 16, cell surface associated	Homo sapiens	158-163
32585607-6	2020	Afterward, Apt-modified AuNP complex was prepared and OVA was then loaded onto this complex.	aunp	24-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	54-57
32672441-4	2020	By incorporating a rigid AuNP core (~10 - 100 nm), the ability of alpha-syn to remodel the vesicle mimics was removed and their surface curvature could be fixed.	aunp	25-29	synuclein alpha	Homo sapiens	66-75
32715254-1	2020	Gold nanoparticle (AuNP) formation by applying pulsed discharge plasma in the slug flow reactor system was demonstrated.	aunp	19-23	snail family transcriptional repressor 2	Homo sapiens	78-82
32381302-6	2020	Under the optimized conditions, limits of detection (LODs) for TTR by AuNP@monolith-SPE-CE-MS were 50 times lower than by CE-MS (5 vs 250 mg L-1, with an ion trap (IT) mass spectrometer).	aunp	70-74	transthyretin	Homo sapiens	63-66
32256179-11	2020	The immunostaining of IL-1beta in spleen of 20 nm AuNP treated mice was subsequently decreased on day 7 whereas it persisted in 50 nm AuNP group.	aunp	50-54	interleukin 1 alpha	Mus musculus	22-30
32256179-11	2020	The immunostaining of IL-1beta in spleen of 20 nm AuNP treated mice was subsequently decreased on day 7 whereas it persisted in 50 nm AuNP group.	aunp	134-138	interleukin 1 alpha	Mus musculus	22-30
32030384-4	2020	Furthermore, the AuNP aggregate promotes the deposition of silver nanoparticles, which were utilized for the electrochemical stripping analysis of the Abeta monomer.	aunp	17-21	amyloid beta (A4) precursor protein	Mus musculus	151-156
31900772-12	2020	AuNP treatments also induced ROS and caspase-3 expressions and reduced the mitochondrial membrane potential.	aunp	0-4	caspase 3	Homo sapiens	37-46
31278549-9	2019	However, in the presence of ATP, the probe MB/Au1 dissociates, and the resulting free DNA2/Au1-(E)-cyclooctene can then react with the Au3-N4, leading to the formation of AuNP aggregates.	aunp	171-175	dna2	None	86-90
31264883-7	2019	The ionic liquids with anions NTf2-, ClO4-, and PF6- make the AuNP surface hydrophobic, indicating their good dispersibility in nonpolar solvents.	aunp	62-66	nuclear transport factor 2	Homo sapiens	30-34
31264883-7	2019	The ionic liquids with anions NTf2-, ClO4-, and PF6- make the AuNP surface hydrophobic, indicating their good dispersibility in nonpolar solvents.	aunp	62-66	sperm associated antigen 17	Homo sapiens	48-51
30856431-4	2019	The AuNP trimer-based biosensor allowed for the selective determination of TROP in the range of 0.1-15 ng mL-1 with the limit of detection (LOD) of 21 pg mL-1 (S/N = 3) and the limit of quantitation (LOQ) of 70 pg mL-1 (S/N = 10).	aunp	4-8	L1 cell adhesion molecule	Mus musculus	106-110
30856431-4	2019	The AuNP trimer-based biosensor allowed for the selective determination of TROP in the range of 0.1-15 ng mL-1 with the limit of detection (LOD) of 21 pg mL-1 (S/N = 3) and the limit of quantitation (LOQ) of 70 pg mL-1 (S/N = 10).	aunp	4-8	L1 cell adhesion molecule	Mus musculus	154-158
30856431-4	2019	The AuNP trimer-based biosensor allowed for the selective determination of TROP in the range of 0.1-15 ng mL-1 with the limit of detection (LOD) of 21 pg mL-1 (S/N = 3) and the limit of quantitation (LOQ) of 70 pg mL-1 (S/N = 10).	aunp	4-8	L1 cell adhesion molecule	Mus musculus	154-158
31003512-9	2019	Additionally, in vitro biological studies indicated that 211At-AuNP-PEG-trastuzumab exhibited higher affinity and cytotoxicity towards the HER2-overexpressing human ovarian SKOV-3 cell line than unmodified nanoparticles.	aunp	63-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-143
30457584-3	2019	In this study, a gold nanoparticle (AuNP)-polyglutamic acid (PGA)-modified indium tin oxide (ITO)-based disposable neuro-biosensor system was designed for alpha-synuclein (alpha-SYN), an important biomarker of Parkinson"s disease.	aunp	36-40	synuclein alpha	Homo sapiens	155-170
30457584-3	2019	In this study, a gold nanoparticle (AuNP)-polyglutamic acid (PGA)-modified indium tin oxide (ITO)-based disposable neuro-biosensor system was designed for alpha-synuclein (alpha-SYN), an important biomarker of Parkinson"s disease.	aunp	36-40	synuclein alpha	Homo sapiens	172-181
30297847-1	2018	A recombinant produced C-terminus of the C. perfringens enterotoxin (C-CPE) was conjugated to gold nanoparticles (AuNPs) to produce a C-CPE-AuNP complex (C-CPE-AuNP).	aunp	114-118	cpe	Clostridium perfringens	56-67
29859458-0	2018	A sensitive electrochemiluminescent biosensor based on AuNP-functionalized ITO for a label-free immunoassay of C-peptide.	aunp	55-59	insulin	Homo sapiens	111-120
30205487-6	2018	Vitoria blue 4R (VB4R) has a strong SERS peak at 1614 cm-1 in the formed AuNP sol substrate.	aunp	73-77	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	36-40
30106592-3	2018	Considering the potential of this peptide, we hereby report a computational study in which well-tempered metadynamics was applied to unveil the interaction of LL37-SH and LL37 with a AuNP with atomistic detail.	aunp	183-187	cathelicidin antimicrobial peptide	Homo sapiens	159-163
30106592-3	2018	Considering the potential of this peptide, we hereby report a computational study in which well-tempered metadynamics was applied to unveil the interaction of LL37-SH and LL37 with a AuNP with atomistic detail.	aunp	183-187	cathelicidin antimicrobial peptide	Homo sapiens	171-175
29458581-5	2018	The presence of Tf on PEGylated AuNP was characterized by dynamic light scattering (DLS) and infrared spectroscopy (IR).	aunp	32-36	transferrin	Homo sapiens	16-18
29632940-7	2018	Employing this dual function (i.e., catalytic and optical property), AuNP-based colorimetry is highlighted as a simple and innovative method for monitoring the efficacy of anti-Abeta reagents.	aunp	69-73	amyloid beta precursor protein	Homo sapiens	177-182
29055194-1	2018	A novel electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) was developed using signal amplification strategy based on poly(5-formylindole)/reduced graphene oxide nanocomposite (P5FIn/erGO) and Au nanoparticle (AuNP) decorated graphene quantum dots (GQDs) (GQDs@AuNP).	aunp	266-270	CEA cell adhesion molecule 5	Homo sapiens	84-108
29055194-1	2018	A novel electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) was developed using signal amplification strategy based on poly(5-formylindole)/reduced graphene oxide nanocomposite (P5FIn/erGO) and Au nanoparticle (AuNP) decorated graphene quantum dots (GQDs) (GQDs@AuNP).	aunp	266-270	CEA cell adhesion molecule 5	Homo sapiens	110-113
28901362-6	2017	We characterise the changes induced by varying AuNP concentrations and medium serum compositions using biochemical assays and correlate them to the corresponding intracellular reporter-free SERS spectra.	aunp	47-51	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	190-194
28902489-3	2017	Here, an orally administered AuNP-siRNA-glycol chitosan-taurocholic acid nanoparticle (AR-GT NPs) was developed to selectively deliver Akt2 siRNA and treat colorectal liver metastases (CLM).	aunp	29-33	AKT serine/threonine kinase 2	Homo sapiens	135-139
29026303-4	2017	Moreover, the miR204 inhibitor was conjugated with gold nanoparticles (AuNP-antagomiR204) and dispersed them in the poly(lactic-co-glycolic acid) (PLGA) solution.	aunp	71-75	microRNA 204	Homo sapiens	14-20
28703075-6	2017	The slow release of insulin from the AuNP@Dextran-insulin conjugates facilitates the lasting of insulin activity.	aunp	37-41	insulin	Homo sapiens	20-27
28703075-6	2017	The slow release of insulin from the AuNP@Dextran-insulin conjugates facilitates the lasting of insulin activity.	aunp	37-41	insulin	Homo sapiens	50-57
28703075-6	2017	The slow release of insulin from the AuNP@Dextran-insulin conjugates facilitates the lasting of insulin activity.	aunp	37-41	insulin	Homo sapiens	50-57
28703075-7	2017	RESULTS &amp; DISCUSSION: AuNP@Dextran-insulin conjugates can prolong insulin activity to 12 h, whereas free form insulin loses activity after 4 h in adipocyte cells.	aunp	26-30	insulin	Homo sapiens	39-46
28703075-7	2017	RESULTS &amp; DISCUSSION: AuNP@Dextran-insulin conjugates can prolong insulin activity to 12 h, whereas free form insulin loses activity after 4 h in adipocyte cells.	aunp	26-30	insulin	Homo sapiens	70-77
28703075-7	2017	RESULTS &amp; DISCUSSION: AuNP@Dextran-insulin conjugates can prolong insulin activity to 12 h, whereas free form insulin loses activity after 4 h in adipocyte cells.	aunp	26-30	insulin	Homo sapiens	70-77
30108854-0	2017	Peptide-fluorophore/AuNP conjugate-based two-photon excited fluorescent nanosensor for caspase-3 activity imaging assay in living cells and tissue.	aunp	20-24	caspase 3	Rattus norvegicus	87-96
28112856-7	2017	These structural features promote its synergetic interactions with Abeta on AuNP surface, leading to strong inhibitions of Abeta oligomerization and fibrillation and the cytotoxicity caused by the aggregation species.	aunp	76-80	amyloid beta precursor protein	Homo sapiens	67-72
28112856-7	2017	These structural features promote its synergetic interactions with Abeta on AuNP surface, leading to strong inhibitions of Abeta oligomerization and fibrillation and the cytotoxicity caused by the aggregation species.	aunp	76-80	amyloid beta precursor protein	Homo sapiens	123-128
28225598-4	2017	As a result, the Rox labels are close to the AuNP surface while the Cy5 labels are away from.	aunp	45-49	MAX network transcriptional repressor	Homo sapiens	17-20
28198433-4	2017	Subsequently, a loop-stem structured capture probe (CP) containing a special IFN-gamma interact strand was modified onto the (+)AuNP surface via the formation of Au-S bonds.	aunp	128-132	interferon gamma	Homo sapiens	77-86
28081255-4	2017	NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53.	aunp	61-65	ataxia telangiectasia mutated	Mus musculus	104-107
28081255-4	2017	NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53.	aunp	61-65	gutter shaped root	Mus musculus	117-120
28081255-4	2017	NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53.	aunp	61-65	peroxiredoxin 6 pseudogene 2	Mus musculus	150-153
28081255-4	2017	NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53.	aunp	61-65	transformation related protein 53	Mus musculus	163-168
28081255-4	2017	NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low- and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53.	aunp	61-65	transformation related protein 53	Mus musculus	305-310
27788375-1	2016	INTRODUCTION: Gold nanoparticles (AuNP; 30nm) were modified with polyethylene glycol (PEG) chains linked to trastuzumab for binding to HER2-positive breast cancer (BC) cells and diethylenetriaminepentaacetic acid (DTPA) for complexing the Auger electron-emitter, 111In (trastuzumab-AuNP-111In).	aunp	34-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-139
27318964-13	2016	In conclusion, layer-by-layer chitosan coated AuNP can be developed as a carrier for iontophoretic delivery of STAT3 siRNA to treat melanoma.	aunp	46-50	signal transducer and activator of transcription 3	Mus musculus	111-116
27095659-3	2016	Both collagen sponges and AuNP-incorporated nanocomposites (CS-Au) were cross-linked with glutaraldehyde (CS-X and CS-AuX).	aunp	26-30	NK2 homeobox 5	Homo sapiens	106-121
27279904-0	2016	Fabrication of Graphene and AuNP Core Polyaniline Shell Nanocomposites as Multifunctional Theranostic Platforms for SERS Real-time Monitoring and Chemo-photothermal Therapy.	aunp	28-32	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	116-120
27279904-1	2016	In this work, novel theranostic platforms based on graphene oxide and AuNP core polyaniline shell (GO-Au@PANI) nanocomposites are fabricated for simultaneous SERS imaging and chemo-photothermal therapy.	aunp	70-74	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	158-162
26974228-2	2016	Our objective was to compare the stability of AuNP conjugated to MCP via a single thiol [DOTA-PEG-ortho-pyridyl disulfide (OPSS)], a dithiol [DOTA-PEG-lipoic acid (LA)] or multithiol end-group [PEG-pGlu(DOTA)8-LA4] and determine the elimination and biodistribution of these (177)Lu-labeled MCP-AuNP in mice.	aunp	46-50	CD46 antigen, complement regulatory protein	Mus musculus	65-68
26974228-15	2016	We conclude that conjugation of AuNP with PEG-pGlu((177)Lu-DOTA)8-LA4 via a multithiol functional group provided the greatest stability in vitro and lowest liver uptake in vivo and is, therefore, the most promising for constructing (177)Lu-MCP-AuNP for radiation treatment of breast cancer.	aunp	32-36	CD46 antigen, complement regulatory protein	Mus musculus	240-243
26718709-5	2016	Simply mixing the K18 peptide with AuNP solution leads to distinct particle aggregation, relative to that by non-acetylated or lysine K14 acetylated control peptides.	aunp	35-39	keratin 18	Homo sapiens	18-21
26759834-6	2016	All of 19 right-handed alpha-amino acids can induce a red-to-blue color change of L-TA-capped AuNP solution, whereas all of the left-handed amino acids (except cysteine) cannot.	aunp	94-98	lymphotoxin alpha	Homo sapiens	82-86
26487089-3	2015	In this aptasensor, Au/hemin@MOFs conjugated with glucose oxidase (GOD) and thrombin binding aptamer (TBA II) were used as the secondary aptamer bioconjugates (Au/hemin@MOF-TBA II-GOD bioconjugates), and TB was sandwiched between Au/hemin@MOF-TBA II-GOD bioconjugates and the amino-terminated TBA I which was self-assembled on the gold nanoparticle (AuNP) modified electrode.	aunp	350-354	coagulation factor II, thrombin	Homo sapiens	76-84
26192215-2	2015	The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG8-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells.	aunp	125-129	IGF2 antisense RNA	Homo sapiens	82-86
26037705-7	2015	Phase transitions were observed at around 55 C and 35 C for the AuNP-loaded ELP1-den and AuNP-loaded ELP2-den, respectively, but not for the corresponding PEGylated dendrimer.	aunp	64-68	elongator acetyltransferase complex subunit 1	Homo sapiens	76-80
26037705-8	2015	In contrast to the AuNP-loaded PEGylated dendrimer, AuNP-loaded ELP2-den readily associated with cells and induced efficient photocytotoxicity at 37 C. The cell association and the photocytotoxicity properties of AuNP-loaded ELP2-den could be controlled by temperature.	aunp	52-56	elongator acetyltransferase complex subunit 2	Homo sapiens	64-68
26037705-8	2015	In contrast to the AuNP-loaded PEGylated dendrimer, AuNP-loaded ELP2-den readily associated with cells and induced efficient photocytotoxicity at 37 C. The cell association and the photocytotoxicity properties of AuNP-loaded ELP2-den could be controlled by temperature.	aunp	52-56	elongator acetyltransferase complex subunit 2	Homo sapiens	225-229
26037705-8	2015	In contrast to the AuNP-loaded PEGylated dendrimer, AuNP-loaded ELP2-den readily associated with cells and induced efficient photocytotoxicity at 37 C. The cell association and the photocytotoxicity properties of AuNP-loaded ELP2-den could be controlled by temperature.	aunp	52-56	elongator acetyltransferase complex subunit 2	Homo sapiens	64-68
26037705-8	2015	In contrast to the AuNP-loaded PEGylated dendrimer, AuNP-loaded ELP2-den readily associated with cells and induced efficient photocytotoxicity at 37 C. The cell association and the photocytotoxicity properties of AuNP-loaded ELP2-den could be controlled by temperature.	aunp	52-56	elongator acetyltransferase complex subunit 2	Homo sapiens	225-229
25947616-6	2015	p-Nitrothiophenol (p-NTP) was used as the probe to evaluate the SERS enhancement of the highly uniform and compact AuNP-Si substrate.	aunp	115-119	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	64-68
25625363-6	2015	Corneal vascular endothelial growth factor receptor 2 level was higher in the control group than in the AuNP-treated group (P = 0.029).	aunp	104-108	kinase insert domain protein receptor	Mus musculus	8-53
25625363-7	2015	AuNP treatment similarly inhibited burn-induced phosphorylation of ERK (P = 0.029).	aunp	0-4	mitogen-activated protein kinase 1	Mus musculus	67-70
25461178-2	2015	The sensor was developed by the layer-by-layer assembly of mercaptopropionic acid (MPA), polyethylene glycol (PEG) functionalized gold nanoparticle (AuNPPEG), capture DNA (DNA-c), target BRCA1 DNA (DNA-t) and gold nanoparticle labeled reporter DNA (DNA-r.AuNP) on gold electrode.	aunp	149-153	BRCA1 DNA repair associated	Homo sapiens	187-192
25597304-7	2015	Therefore, the AuNP-based colorimetric biosensor has great potential in the diagnosis of ADA-relevant diseases and drug screening.	aunp	15-19	adenosine deaminase	Homo sapiens	89-92
25644549-5	2015	Successive conjugation of AuNP@SiO2, CdSe QD and anti-CA-125 mAb onto the gold electrode resulted in sensitive detection of CA-125 with a limit of detection (LOD) of 0.0016 U mL(-1) and a linear detection range (LDR) of 0-0.1 U mL(-1).	aunp	26-30	mucin 16, cell surface associated	Homo sapiens	124-130
32261976-3	2015	The ligation is based on the specific interactions between t-PA and epsilon-lysine (a ligand that has affinity to a specific domain in t-PA) immobilized on the AuNP surface through polyvinyl pyrrolidone (PVP) as a spacer.	aunp	160-164	plasminogen activator, tissue type	Homo sapiens	59-63
32261976-3	2015	The ligation is based on the specific interactions between t-PA and epsilon-lysine (a ligand that has affinity to a specific domain in t-PA) immobilized on the AuNP surface through polyvinyl pyrrolidone (PVP) as a spacer.	aunp	160-164	plasminogen activator, tissue type	Homo sapiens	135-139
25487127-1	2014	Gold-silver core-shell nanoparticles stabilized with a common sweetener, aspartame (AuNP@Ag@Asm), combine the antimicrobial properties of silver with the photoinduced plasmon-mediated photothermal effects of gold.	aunp	84-88	H19 imprinted maternally expressed transcript	Homo sapiens	92-95
25027175-6	2014	The percentage of macrophages containing AuNP tended to be lower in Scnn1b-Tg than in WT mice.	aunp	41-45	sodium channel, nonvoltage-gated 1 beta	Mus musculus	68-74
32261466-3	2014	Fe3O4@AuNP nanocomposites were used as labels of luminol, glucose oxidase (GOx) and signal aptamer which greatly enhanced the chemiluminescence emission and provided a simple magnetic separation approach to attain interference-free measurement for real detection.	aunp	6-10	hydroxyacid oxidase 1	Homo sapiens	58-73
32261466-3	2014	Fe3O4@AuNP nanocomposites were used as labels of luminol, glucose oxidase (GOx) and signal aptamer which greatly enhanced the chemiluminescence emission and provided a simple magnetic separation approach to attain interference-free measurement for real detection.	aunp	6-10	hydroxyacid oxidase 1	Homo sapiens	75-78
24370115-1	2014	An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies.	aunp	99-103	interleukin 6	Homo sapiens	3-16
24370115-1	2014	An Interleukin-6 (IL-6) electrochemical immunosensor was fabricated based on the Au nanoparticles (AuNP)-graphene-silica sol-gel as immobilization biointerface and AuNP-polydopamine (PDA)@carbon nanotubes (CNT) as the label of HRP-bound antibodies.	aunp	99-103	interleukin 6	Homo sapiens	18-22
24370115-2	2014	The AuNP-graphene-silica sol-gel film was prepared in situ and modified on the ITO electrode, providing a stable network for the immobilization of antibody and exhibiting a dynamic working range of 1-40 pg/mL with a low detection limit of 0.3 pg/mL IL-6 (at 3s).	aunp	4-8	interleukin 6	Homo sapiens	249-253
24411335-5	2014	The results of an inverted fluorescence microscopy, flow cytometry (FCM) and western blotting methods demonstrated that PC-3 prostate cancer cells treated with EGFP-p53/PEI/PAH-Cit/AuNP-CS expressed higher levels of GFP than cells treated with EGFP-p53/PEI.	aunp	181-185	tumor protein p53	Homo sapiens	249-252
23884371-0	2013	Molecular interactions of different size AuNP-COOH nanoparticles with human fibrinogen.	aunp	41-45	fibrinogen beta chain	Homo sapiens	76-86
23680060-13	2013	CONCLUSIONS: Inhaled AuNP rapidly bound to the alveolar epithelium in both Wt and Scnn1b-Tg mice.	aunp	21-25	sodium channel, nonvoltage-gated 1 beta	Mus musculus	82-88
23680060-14	2013	Scnn1b-Tg mice showed less efficient AuNP uptake by surface macrophages and concomitant higher particle internalization by alveolar type I epithelial cells compared to Wt mice.	aunp	37-41	sodium channel, nonvoltage-gated 1 beta	Mus musculus	0-6
23041411-5	2013	Furthermore, overexpression of KDEL receptor (KDELR) significantly enhanced KDEL peptide uptake in both free and AuNP-conjugated forms.	aunp	113-117	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	31-44
23041411-5	2013	Furthermore, overexpression of KDEL receptor (KDELR) significantly enhanced KDEL peptide uptake in both free and AuNP-conjugated forms.	aunp	113-117	KDEL endoplasmic reticulum protein retention receptor 1	Homo sapiens	46-51
23469154-12	2013	A reduction in TNFalpha and IL-6 mRNA levels in the fat were observed from 1 h to 72 h post AuNP injection, with no observable changes in macrophage number.	aunp	92-96	tumor necrosis factor	Mus musculus	15-23
23469154-12	2013	A reduction in TNFalpha and IL-6 mRNA levels in the fat were observed from 1 h to 72 h post AuNP injection, with no observable changes in macrophage number.	aunp	92-96	interleukin 6	Mus musculus	28-32
22985875-4	2012	We tested the 3-5 nm AuNP, epigallocatechin gallate (EGCG), and alpha-lipoic acid (ALA) could change the RAGE expression and be helpful in diabetic wound.	aunp	21-25	advanced glycosylation end product-specific receptor	Mus musculus	105-109
22985875-5	2012	The mixture of AuNP+EGCG+ALA (AuEA) significantly attenuated the AGE-induced RAGE protein expression in fibroblasts (Hs68).	aunp	15-19	advanced glycosylation end product-specific receptor	Mus musculus	77-81
22444512-2	2012	A novel stable gold nanoparticle (AuNP)-modified glassy carbon (GC) electrode interface (GC-Ph-AuNP)-based biosensor for detecting carcinoembryonic antigen (CEA) was developed.	aunp	34-38	CEA cell adhesion molecule 3	Homo sapiens	131-155
22444512-2	2012	A novel stable gold nanoparticle (AuNP)-modified glassy carbon (GC) electrode interface (GC-Ph-AuNP)-based biosensor for detecting carcinoembryonic antigen (CEA) was developed.	aunp	34-38	CEA cell adhesion molecule 3	Homo sapiens	157-160
22444512-2	2012	A novel stable gold nanoparticle (AuNP)-modified glassy carbon (GC) electrode interface (GC-Ph-AuNP)-based biosensor for detecting carcinoembryonic antigen (CEA) was developed.	aunp	95-99	CEA cell adhesion molecule 3	Homo sapiens	131-155
22444512-2	2012	A novel stable gold nanoparticle (AuNP)-modified glassy carbon (GC) electrode interface (GC-Ph-AuNP)-based biosensor for detecting carcinoembryonic antigen (CEA) was developed.	aunp	95-99	CEA cell adhesion molecule 3	Homo sapiens	157-160
23730120-3	2012	As film thickness increased, voltammetric peak currents for surface myoglobin (Mb) on these films decreased but the electron transfer rate was relatively constant, consistent with a AuNP-mediated electron hopping mechanism.	aunp	182-186	myoglobin	Homo sapiens	68-77
22512858-5	2012	The Ag-based SPR spectra showed a red shift (0.7 nm) when free BPA (0.1 mM) was passed over the BPA-AuNp/immobilized MIP-Np complexes formed on the s_OWG, unlike the case for the Au deposition band, while a large excess of BPA induced a blue shift due to the competitive desorption of BPA-AuNp from the immobilized MIP-Np on the s_OWG.	aunp	100-104	sepiapterin reductase	Homo sapiens	13-16
22036101-1	2012	We describe in this study whether the gold nanoparticle (AuNP) surface-functionalized with PEG, biotin, paclitaxel (PTX) and rhodamine B linked beta-cyclodextrin (beta-CD) (AuNP-5") can be useful as a theranostic agent for cancer therapy without the cytotoxic effect on normal cells.	aunp	57-61	beta-carotene oxygenase 1	Mus musculus	163-170
21866979-2	2011	In the present study, the interaction of luminescent water-soluble gold nanoparticles (AuNP-1 Eu-nta), obtained through the self-assembly of a naphthalene beta-diketone antenna with a Eu(III) cyclen complex tethered to the gold surface via a C(12) alkyl thiol spacer, with bovine serum albumin (BSA) was investigated.	aunp	87-91	albumin	Homo sapiens	280-293
21315682-1	2011	An amperometric uric acid biosensor was fabricated by immobilizing uricase (EC 1.7.3.3) onto gold nanoparticle (AuNP)/multiwalled carbon nanotube (MWCNT) layer deposited on Au electrode via carbodiimide linkage.	aunp	112-116	urate oxidase (pseudogene)	Homo sapiens	67-74
21295342-4	2011	The calculation of the bimolecular quenching constant using the Stern-Volmer equation confirms that the dominant mechanism involved in quenching of fluorescence of rec1-resilin in the presence of AuNP is static.	aunp	196-200	RAD1 checkpoint DNA exonuclease	Homo sapiens	164-168
20095580-4	2010	Then, cocaine aptamer fragments, SH-C2, were covalently labeled onto the outermost AuNP layer.	aunp	83-87	SHC adaptor protein 2	Homo sapiens	33-38
19717294-3	2009	To obtain the final sensor probe, an antibody (anti-Annexin II) and hydrazine (Hyd), which is a catalyst for the reduction of H(2)O(2) generated by glucose oxidase (GOx), were covalently attached onto the Den/AuNP-modified surface.	aunp	209-213	annexin A2	Homo sapiens	52-62
19717294-3	2009	To obtain the final sensor probe, an antibody (anti-Annexin II) and hydrazine (Hyd), which is a catalyst for the reduction of H(2)O(2) generated by glucose oxidase (GOx), were covalently attached onto the Den/AuNP-modified surface.	aunp	209-213	hydroxyacid oxidase 1	Homo sapiens	165-168
19956788-6	2008	Although the histone deacetylase 8 bound to AuNP via mode-2 exhibits the same inhibitory potency against Trichostatin A as the free enzyme, the former is more susceptible to thermal denaturation.	aunp	44-48	histone deacetylase 8	Homo sapiens	13-34
18826263-4	2008	Herein, AuNP has enabled the easy and efficient immobilization of the antibody (Cetuximab), which can selectively interact with epidermal growth factor receptor (EGFR) on the surface of epidermal cancer, as detecting moiety onto the AuNP-deposited substrate without nanolithography process.	aunp	8-12	epidermal growth factor receptor	Homo sapiens	128-160
18826263-4	2008	Herein, AuNP has enabled the easy and efficient immobilization of the antibody (Cetuximab), which can selectively interact with epidermal growth factor receptor (EGFR) on the surface of epidermal cancer, as detecting moiety onto the AuNP-deposited substrate without nanolithography process.	aunp	8-12	epidermal growth factor receptor	Homo sapiens	162-166
18826263-5	2008	After conjugation of Cetuximab with AuNP-deposited substrate, Cetuximab-conjugated probe as a live cancer cell detector (LCCD) could detect EGFR-highexpressed A431 cells related to epithelial cancer with 54-times larger specificity and sensitivity in comparison with EGFR-deficient MCF7 cells.	aunp	36-40	epidermal growth factor receptor	Homo sapiens	140-144
18826263-5	2008	After conjugation of Cetuximab with AuNP-deposited substrate, Cetuximab-conjugated probe as a live cancer cell detector (LCCD) could detect EGFR-highexpressed A431 cells related to epithelial cancer with 54-times larger specificity and sensitivity in comparison with EGFR-deficient MCF7 cells.	aunp	36-40	epidermal growth factor receptor	Homo sapiens	267-271
16797959-2	2007	CEA antibody (CEAAb) was covalently attached on glutathione (GSH) monolayer-modified gold nanoparticle (AuNP) and the resulting CEAAb-AuNP bioconjugates were immobilized on Au electrode by electro-copolymerization with o-aminophenol (OAP).	aunp	104-108	CEA cell adhesion molecule 3	Homo sapiens	0-3
16797959-3	2007	Electrochemical impedance spectroscopy and cyclic voltammetry studies demonstrate that the formation of CEA antibody-antigen complexes increases the electron transfer resistance of [Fe(CN)(6)](3-/4-) redox pair at the poly-OAP/CEAAb-AuNP/Au electrode.	aunp	233-237	CEA cell adhesion molecule 3	Homo sapiens	104-107
17002381-2	2006	By placing Au nanoparticles (AuNP) atop the immobilized SOD1 by means of a gold-thiol assembly, the nanoscale motion of SOD1 at the interface produces mechanical work to lift and then lower the AuNP from the Au substrate by a distance of ca.	aunp	29-33	superoxide dismutase 1	Homo sapiens	56-60
17002381-2	2006	By placing Au nanoparticles (AuNP) atop the immobilized SOD1 by means of a gold-thiol assembly, the nanoscale motion of SOD1 at the interface produces mechanical work to lift and then lower the AuNP from the Au substrate by a distance of ca.	aunp	29-33	superoxide dismutase 1	Homo sapiens	120-124