PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34057472-11	2021	Furthermore, an addition of 18beta-glycyrrhetinic acid (18-GA; a HSD17B2 inhibitor) to cortisol and FSH-containing medium increased apoptosis of VF granulosa cells.	18alpha-glycyrrhetinic acid	28-54	hydroxysteroid 17-beta dehydrogenase 2	Sus scrofa	65-72
34057472-11	2021	Furthermore, an addition of 18beta-glycyrrhetinic acid (18-GA; a HSD17B2 inhibitor) to cortisol and FSH-containing medium increased apoptosis of VF granulosa cells.	18alpha-glycyrrhetinic acid	28-54	follicle stimulating hormone beta	Mus musculus	100-103
34057472-11	2021	Furthermore, an addition of 18beta-glycyrrhetinic acid (18-GA; a HSD17B2 inhibitor) to cortisol and FSH-containing medium increased apoptosis of VF granulosa cells.	18alpha-glycyrrhetinic acid	56-61	hydroxysteroid 17-beta dehydrogenase 2	Sus scrofa	65-72
34057472-11	2021	Furthermore, an addition of 18beta-glycyrrhetinic acid (18-GA; a HSD17B2 inhibitor) to cortisol and FSH-containing medium increased apoptosis of VF granulosa cells.	18alpha-glycyrrhetinic acid	56-61	follicle stimulating hormone beta	Mus musculus	100-103
34022703-11	2021	Macroscopic and staining-based observations of mouse ears and the levels of proinflammatory factors and myeloperoxidase revealed that the Nano GA hydrogel exhibited better anti-edema ability and more strongly inhibited inflammation development than the Coarse GA hydrogel and indomethacin hydrogel (positive drug).	18alpha-glycyrrhetinic acid	143-145	myeloperoxidase	Mus musculus	104-119
33986260-4	2021	18beta-glycyrrhetinic acid (GA) has been proposed as a promising hepatoprotective agent.	18alpha-glycyrrhetinic acid	28-30	olfactory receptor family 7 subfamily D member 10	Mus musculus	0-6
33986260-5	2021	We hypothesized that GA significantly alleivates D-GalN/LPS-induced ALI, which involved in PXR-mediated autophagy and lysosome biogenesis.	18alpha-glycyrrhetinic acid	21-23	galanin and GMAP prepropeptide	Mus musculus	51-55
33986260-5	2021	We hypothesized that GA significantly alleivates D-GalN/LPS-induced ALI, which involved in PXR-mediated autophagy and lysosome biogenesis.	18alpha-glycyrrhetinic acid	21-23	nuclear receptor subfamily 1, group I, member 2	Mus musculus	91-94
33986260-6	2021	We found that GA can significantly decrease hepatocyte apoptosis and increase the hepatic autophagy marker LC3-B.	18alpha-glycyrrhetinic acid	14-16	microtubule-associated protein 1 light chain 3 beta	Mus musculus	107-112
33986260-8	2021	Simultaneously, GA markedly activates PXR, even reversing the D-GalN/LPS-induced reduction of PXR and its downstream genes.	18alpha-glycyrrhetinic acid	16-18	nuclear receptor subfamily 1, group I, member 2	Mus musculus	38-41
33986260-8	2021	Simultaneously, GA markedly activates PXR, even reversing the D-GalN/LPS-induced reduction of PXR and its downstream genes.	18alpha-glycyrrhetinic acid	16-18	galanin and GMAP prepropeptide	Mus musculus	64-68
33986260-8	2021	Simultaneously, GA markedly activates PXR, even reversing the D-GalN/LPS-induced reduction of PXR and its downstream genes.	18alpha-glycyrrhetinic acid	16-18	nuclear receptor subfamily 1, group I, member 2	Mus musculus	94-97
33986260-9	2021	In contrast, GA has a weak protective effect in pharmacological inhibition of PXR and PXR-null mice, which significantly affected apoptosis- and autophagy-related genes.	18alpha-glycyrrhetinic acid	13-15	nuclear receptor subfamily 1, group I, member 2	Mus musculus	78-81
33986260-9	2021	In contrast, GA has a weak protective effect in pharmacological inhibition of PXR and PXR-null mice, which significantly affected apoptosis- and autophagy-related genes.	18alpha-glycyrrhetinic acid	13-15	nuclear receptor subfamily 1, group I, member 2	Mus musculus	86-89
33986260-10	2021	PXR knockout interferes with the stability of autophagosomes and lysosomes, preventing GA reducing the expression of lysosomal genes such as Cst B and TPP1, and suppressing autophagy flow.	18alpha-glycyrrhetinic acid	87-89	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-3
33986260-11	2021	Therefore, we believe that GA increases autophagy by inhibiting autophagosome-lysosome fusion and blocked autophagy flux via activation of PXR.	18alpha-glycyrrhetinic acid	27-29	nuclear receptor subfamily 1, group I, member 2	Mus musculus	139-142
33986260-12	2021	In conclusion, our results show that GA activates PXR to regulate autophagy and lysosome biogenesis, represented by inhibiting autophagosome-lysosome fusion and stabilization of lysosome.	18alpha-glycyrrhetinic acid	37-39	nuclear receptor subfamily 1, group I, member 2	Mus musculus	50-53
33986260-13	2021	These results identify a new mechanism by which GA-dependent PXR activation reduces D-GalN/LPS-induced acute liver injury.	18alpha-glycyrrhetinic acid	48-50	nuclear receptor subfamily 1, group I, member 2	Mus musculus	61-64
33986260-13	2021	These results identify a new mechanism by which GA-dependent PXR activation reduces D-GalN/LPS-induced acute liver injury.	18alpha-glycyrrhetinic acid	48-50	galanin and GMAP prepropeptide	Mus musculus	86-90
33384302-7	2021	Pharmacologic inhibition of Cx43 with 18beta-Glycyrrhetinic acid (18beta-GA) exhibits a negative inotropic effect on the myometrium in a dose-dependent manner, as does administration of nebivolol, a nitric oxide synthase (NOS) activator that increases total protein SNOs.	18alpha-glycyrrhetinic acid	38-64	gap junction protein alpha 1	Homo sapiens	28-32
33384302-7	2021	Pharmacologic inhibition of Cx43 with 18beta-Glycyrrhetinic acid (18beta-GA) exhibits a negative inotropic effect on the myometrium in a dose-dependent manner, as does administration of nebivolol, a nitric oxide synthase (NOS) activator that increases total protein SNOs.	18alpha-glycyrrhetinic acid	66-75	gap junction protein alpha 1	Homo sapiens	28-32
33384302-7	2021	Pharmacologic inhibition of Cx43 with 18beta-Glycyrrhetinic acid (18beta-GA) exhibits a negative inotropic effect on the myometrium in a dose-dependent manner, as does administration of nebivolol, a nitric oxide synthase (NOS) activator that increases total protein SNOs.	18alpha-glycyrrhetinic acid	66-75	nitric oxide synthase 2	Homo sapiens	199-220
33384302-12	2021	Here we have identified that Cx43, an important contractile-associated protein, is dysregulated in sPTL myometrium, and that the pharmacologic inhibition of Cx43, and its S-nitrosation, with 18beta-GA and nebivolol, respectively, significantly blunts contraction in human myometrial tissue, presenting a novel approach to tocolysis that leverages maladjusted pathways in women who experience sPTL.	18alpha-glycyrrhetinic acid	191-200	gap junction protein alpha 1	Homo sapiens	29-33
33384302-12	2021	Here we have identified that Cx43, an important contractile-associated protein, is dysregulated in sPTL myometrium, and that the pharmacologic inhibition of Cx43, and its S-nitrosation, with 18beta-GA and nebivolol, respectively, significantly blunts contraction in human myometrial tissue, presenting a novel approach to tocolysis that leverages maladjusted pathways in women who experience sPTL.	18alpha-glycyrrhetinic acid	191-200	gap junction protein alpha 1	Homo sapiens	157-161
32493482-0	2020	18beta-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice.	18alpha-glycyrrhetinic acid	0-26	AKT serine/threonine kinase 1	Homo sapiens	97-100
33603672-20	2021	Inhibition of gap junctions by Ga alleviated renal tubular oxidative injury via improvement of thioredoxin 1-mediated redox signaling.	18alpha-glycyrrhetinic acid	31-33	thioredoxin 1	Rattus norvegicus	95-108
32908937-2	2020	18beta-Glycyrrhetinic acid (GA), one of the main ingredients of Licorice (Glycyrrhiza glabra L.), has been shown to have numerous pharmacological effects such as antioxidative, antitumor, and anti-inflammatory activities.	18alpha-glycyrrhetinic acid	28-30	olfactory receptor family 7 subfamily D member 10	Mus musculus	0-6
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	interleukin 6	Mus musculus	38-42
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	tumor necrosis factor	Mus musculus	44-53
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	interleukin 17A	Mus musculus	55-60
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	interleukin 23, alpha subunit p19	Mus musculus	62-67
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	interleukin 1 alpha	Mus musculus	73-81
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	CD4 antigen	Mus musculus	126-129
32908937-6	2020	GA also suppressed the mRNA levels of IL-6, TNF-alpha, IL-17, IL-23, and IL-1beta in the skin and increased the proportion of CD4+ Foxp3+ regulatory T cells (Tregs) in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	0-2	forkhead box P3	Mus musculus	131-136
32908937-8	2020	In conclusion, GA ameliorated the symptoms of psoriasis, at least in part, through inhibition of inflammatory cytokines and STAT3/mTOR signaling and activation of Tregs in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	15-17	signal transducer and activator of transcription 3	Mus musculus	124-129
32908937-8	2020	In conclusion, GA ameliorated the symptoms of psoriasis, at least in part, through inhibition of inflammatory cytokines and STAT3/mTOR signaling and activation of Tregs in both lymph nodes and spleens.	18alpha-glycyrrhetinic acid	15-17	mechanistic target of rapamycin kinase	Mus musculus	130-134
32583610-9	2020	RESULTS: Thymic stromal lymphopoietin secretion was inhibited significantly in an AD environment by TTLE and GA by up to 57.2% and 73.3%, respectively.	18alpha-glycyrrhetinic acid	109-111	thymic stromal lymphopoietin	Homo sapiens	9-37
32583610-12	2020	CONCLUSIONS: A topical spray containing TTLE and GA, which inhibit TSLP secretion, efficiently decreases AD pruritus and improves the quality of life of AD patients.	18alpha-glycyrrhetinic acid	49-51	thymic stromal lymphopoietin	Homo sapiens	67-71
32353589-2	2020	18beta-glycyrrhetinic acid (GA) is an active ingredient of Glycyrrhiza uralensis an herbal medicine used for treating liver aliments.	18alpha-glycyrrhetinic acid	28-30	olfactory receptor family 2 subfamily F member 1B	Mus musculus	0-6
32353589-3	2020	In this study, we established that GA functions as a partial antagonist of HNF4alpha through HNF4alpha-driven reporter luciferase assay and co-immunoprecipitation experiments with co-activator PGC1alpha.	18alpha-glycyrrhetinic acid	35-37	hepatic nuclear factor 4, alpha	Mus musculus	75-84
32353589-3	2020	In this study, we established that GA functions as a partial antagonist of HNF4alpha through HNF4alpha-driven reporter luciferase assay and co-immunoprecipitation experiments with co-activator PGC1alpha.	18alpha-glycyrrhetinic acid	35-37	hepatic nuclear factor 4, alpha	Mus musculus	93-102
32353589-3	2020	In this study, we established that GA functions as a partial antagonist of HNF4alpha through HNF4alpha-driven reporter luciferase assay and co-immunoprecipitation experiments with co-activator PGC1alpha.	18alpha-glycyrrhetinic acid	35-37	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	193-202
32353589-5	2020	Importantly, GA suppressed the expression of HNF4alpha target genes such as apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B) modulating hepatic VLDL secretion in mice fed on a high fat diet.	18alpha-glycyrrhetinic acid	13-15	hepatic nuclear factor 4, alpha	Mus musculus	45-54
32353589-5	2020	Importantly, GA suppressed the expression of HNF4alpha target genes such as apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B) modulating hepatic VLDL secretion in mice fed on a high fat diet.	18alpha-glycyrrhetinic acid	13-15	apolipoprotein B	Mus musculus	76-92
32353589-5	2020	Importantly, GA suppressed the expression of HNF4alpha target genes such as apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B) modulating hepatic VLDL secretion in mice fed on a high fat diet.	18alpha-glycyrrhetinic acid	13-15	apolipoprotein B	Mus musculus	94-98
32353589-5	2020	Importantly, GA suppressed the expression of HNF4alpha target genes such as apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B) modulating hepatic VLDL secretion in mice fed on a high fat diet.	18alpha-glycyrrhetinic acid	13-15	lysosomal-associated protein transmembrane 4A	Mus musculus	143-146
32353589-5	2020	Importantly, GA suppressed the expression of HNF4alpha target genes such as apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B) modulating hepatic VLDL secretion in mice fed on a high fat diet.	18alpha-glycyrrhetinic acid	13-15	phospholipase A2, group XIIB	Mus musculus	152-173
32353589-5	2020	Importantly, GA suppressed the expression of HNF4alpha target genes such as apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B) modulating hepatic VLDL secretion in mice fed on a high fat diet.	18alpha-glycyrrhetinic acid	13-15	phospholipase A2, group XIIB	Mus musculus	175-183
32353589-6	2020	In addition, GA also suppressed gluconeogenesis and ameliorated glucose intolerance via down-regulating the expression of HNF4alpha target genes glucose-6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase (Pepck).	18alpha-glycyrrhetinic acid	13-15	hepatic nuclear factor 4, alpha	Mus musculus	122-131
32353589-6	2020	In addition, GA also suppressed gluconeogenesis and ameliorated glucose intolerance via down-regulating the expression of HNF4alpha target genes glucose-6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase (Pepck).	18alpha-glycyrrhetinic acid	13-15	glucose-6-phosphatase, catalytic	Mus musculus	145-166
32353589-6	2020	In addition, GA also suppressed gluconeogenesis and ameliorated glucose intolerance via down-regulating the expression of HNF4alpha target genes glucose-6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase (Pepck).	18alpha-glycyrrhetinic acid	13-15	glucose-6-phosphatase, catalytic	Mus musculus	168-172
32353589-6	2020	In addition, GA also suppressed gluconeogenesis and ameliorated glucose intolerance via down-regulating the expression of HNF4alpha target genes glucose-6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase (Pepck).	18alpha-glycyrrhetinic acid	13-15	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	178-211
32353589-6	2020	In addition, GA also suppressed gluconeogenesis and ameliorated glucose intolerance via down-regulating the expression of HNF4alpha target genes glucose-6-phosphatase (G6pc) and phosphoenolpyruvate carboxykinase (Pepck).	18alpha-glycyrrhetinic acid	13-15	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	213-218
32353589-8	2020	In all, we established that GA acts as a partial HNF4alpha antagonist modulating lipid and carbohydrate metabolism.	18alpha-glycyrrhetinic acid	28-30	hepatic nuclear factor 4, alpha	Mus musculus	49-58
33603672-17	2021	Furthermore, Ga restored the expression of thioredoxin 1 inhibited by Px-12.	18alpha-glycyrrhetinic acid	13-15	thioredoxin 1	Rattus norvegicus	43-56
32737847-0	2020	Correction to: Transcriptional suppression of androgen receptor by 18beta-glycyrrhetinic acid in LNCaP human prostate cancer cells.	18alpha-glycyrrhetinic acid	67-93	androgen receptor	Homo sapiens	46-63
32270355-7	2020	(1) TGF- beta1 induced the vascular SMCs switching to synthetic phenotype; (2) Cx43 was significantly increased, and Cx40 and Cx45 were decreased in HL-1 cocultured with synthetic SMCs; (3) The fluorescence intensity of Lucifer yellow was higher in HL-1 cocultured with synthetic SMCs than that in the cells cocultured with contractile SMCs, which was inhibited by18-alpha-GA; (4) the expression of microRNA 27b was increased in HL-1 cocultured with synthetic SMCs, which was attenuated markedly by 18-alpha-GA. (5) the expression of ZFHX3 was decreased in HL-1 cocultured with synthetic SMCs, which was reversed by 18-alpha-GA.	18alpha-glycyrrhetinic acid	364-375	transforming growth factor beta 1	Homo sapiens	4-14
32493482-16	2020	NAC, a ROS inhibitor, attenuated GA-mediated HaCaT keratinocytes growth inhibition and apoptosis.	18alpha-glycyrrhetinic acid	33-35	NLR family, pyrin domain containing 1A	Mus musculus	0-3
32493482-17	2020	In addition, GA treatment remarkably decreased p-Akt protein level, which could be restored partially when cells were co-treated with GA and NAC.	18alpha-glycyrrhetinic acid	13-15	thymoma viral proto-oncogene 1	Mus musculus	49-52
32493482-17	2020	In addition, GA treatment remarkably decreased p-Akt protein level, which could be restored partially when cells were co-treated with GA and NAC.	18alpha-glycyrrhetinic acid	13-15	NLR family, pyrin domain containing 1A	Mus musculus	141-144
32493482-17	2020	In addition, GA treatment remarkably decreased p-Akt protein level, which could be restored partially when cells were co-treated with GA and NAC.	18alpha-glycyrrhetinic acid	134-136	thymoma viral proto-oncogene 1	Mus musculus	49-52
32493482-20	2020	CONCLUSIONS: GA inhibits proliferation and induces apoptosis in HaCaT keratinocytes through ROS-mediated inhibition of PI3K-Akt signaling pathway, and ameliorates IMQ-induced psoriasis-like skin lesions in mice.	18alpha-glycyrrhetinic acid	13-15	thymoma viral proto-oncogene 1	Mus musculus	124-127
32219716-0	2020	Transcriptional suppression of androgen receptor by 18beta-glycyrrhetinic acid in LNCaP human prostate cancer cells.	18alpha-glycyrrhetinic acid	52-78	androgen receptor	Homo sapiens	31-48
32219716-2	2020	Here, we report the novel mechanisms by which 18beta-glycyrrhetinic acid (GA) targets AR to stimulate cell death in both hormone-responsive and -refractory prostate cancer cells.	18alpha-glycyrrhetinic acid	46-72	androgen receptor	Homo sapiens	86-88
32219716-4	2020	Moreover, GA not only suppressed the expression of androgen target genes (TMPRSS2, PSA, and NKX3.1), but also enhanced the suppressive effect of anti-androgens (bicalutamide and flutamide) on LNCaP cell growth.	18alpha-glycyrrhetinic acid	10-12	transmembrane serine protease 2	Homo sapiens	74-81
32219716-2	2020	Here, we report the novel mechanisms by which 18beta-glycyrrhetinic acid (GA) targets AR to stimulate cell death in both hormone-responsive and -refractory prostate cancer cells.	18alpha-glycyrrhetinic acid	74-76	androgen receptor	Homo sapiens	86-88
32219716-4	2020	Moreover, GA not only suppressed the expression of androgen target genes (TMPRSS2, PSA, and NKX3.1), but also enhanced the suppressive effect of anti-androgens (bicalutamide and flutamide) on LNCaP cell growth.	18alpha-glycyrrhetinic acid	10-12	NK3 homeobox 1	Homo sapiens	92-98
32219716-3	2020	We found that miR-488, a tumor suppressive microRNA, was markedly induced by GA treatment, resulting in the down-regulation of AR expression and inhibition of cellular responses mediated by androgens.	18alpha-glycyrrhetinic acid	77-79	microRNA 488	Homo sapiens	14-21
32219716-3	2020	We found that miR-488, a tumor suppressive microRNA, was markedly induced by GA treatment, resulting in the down-regulation of AR expression and inhibition of cellular responses mediated by androgens.	18alpha-glycyrrhetinic acid	77-79	androgen receptor	Homo sapiens	127-129
31617997-3	2019	This paper reports a multifunctional size-switchable nanoparticle (denoted DGL (dendrigraft poly-l-lysine) (DGL)/GEM@PP/GA) for TAF-targeted regulation and deep tumor penetration.	18alpha-glycyrrhetinic acid	120-122	TATA-box binding protein associated factor 8	Homo sapiens	128-131
31883490-0	2020	A 18beta-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.	18alpha-glycyrrhetinic acid	2-28	histone deacetylase 3	Homo sapiens	64-69
31883490-0	2020	A 18beta-glycyrrhetinic acid conjugate with Vorinostat degrades HDAC3 and HDAC6 with improved antitumor effects.	18alpha-glycyrrhetinic acid	2-28	histone deacetylase 6	Homo sapiens	74-79
31883490-1	2020	Semisynthetic 18beta-glycyrrhetinic acid (GA) analogues bearing 1-en-2-cyano-3-oxo substitution on ring A have enhanced antitumor effects with reduced levels of HDAC3 and HDAC6 proteins.	18alpha-glycyrrhetinic acid	14-40	histone deacetylase 3	Homo sapiens	161-166
31883490-1	2020	Semisynthetic 18beta-glycyrrhetinic acid (GA) analogues bearing 1-en-2-cyano-3-oxo substitution on ring A have enhanced antitumor effects with reduced levels of HDAC3 and HDAC6 proteins.	18alpha-glycyrrhetinic acid	14-40	histone deacetylase 6	Homo sapiens	171-176
31883490-1	2020	Semisynthetic 18beta-glycyrrhetinic acid (GA) analogues bearing 1-en-2-cyano-3-oxo substitution on ring A have enhanced antitumor effects with reduced levels of HDAC3 and HDAC6 proteins.	18alpha-glycyrrhetinic acid	42-44	histone deacetylase 3	Homo sapiens	161-166
31883490-1	2020	Semisynthetic 18beta-glycyrrhetinic acid (GA) analogues bearing 1-en-2-cyano-3-oxo substitution on ring A have enhanced antitumor effects with reduced levels of HDAC3 and HDAC6 proteins.	18alpha-glycyrrhetinic acid	42-44	histone deacetylase 6	Homo sapiens	171-176
31505326-0	2020	The dietary triterpenoid 18alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.	18alpha-glycyrrhetinic acid	25-52	mitogen-activated protein kinase 1	Homo sapiens	104-107
31505326-0	2020	The dietary triterpenoid 18alpha-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.	18alpha-glycyrrhetinic acid	25-52	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
31505326-1	2020	18alpha-Glycyrrhetinic acid (18alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context.	18alpha-glycyrrhetinic acid	0-27	NFE2 like bZIP transcription factor 2	Homo sapiens	105-148
31505326-1	2020	18alpha-Glycyrrhetinic acid (18alpha-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context.	18alpha-glycyrrhetinic acid	0-27	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
31617997-6	2019	However, residual GA-loaded nanoparticles with lower tumor penetration ability could accumulate around tumor vessels and be preferentially absorbed by TAFs to regulate the secretion of Wnt 16, which is an important DRP molecule.	18alpha-glycyrrhetinic acid	18-20	Wnt family member 16	Homo sapiens	185-191
31325423-0	2019	Protective effects of 18beta-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway.	18alpha-glycyrrhetinic acid	22-48	ras homolog family member A	Rattus norvegicus	102-107
31615045-3	2019	Despite many reported health benefits, 3MGA and GA inhibit the 11-beta-hydrogenase type II enzyme (11beta-HSD2) oxidizing cortisol to cortisone.	18alpha-glycyrrhetinic acid	41-43	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	66-110
30364936-0	2019	18beta-glycyrrhetinic acid inhibited mitochondrial energy metabolism and gastric carcinogenesis through methylation-regulated TLR2 signaling pathway.	18alpha-glycyrrhetinic acid	0-26	toll like receptor 2	Homo sapiens	126-130
31284098-7	2019	By using a gap junction (GJ) inhibitor, 18beta-glycyrrhetinic acid, we demonstrated that Cx43 facilitated the delivery of siRNA into Cx43-expressing U87 MG cells.	18alpha-glycyrrhetinic acid	40-66	gap junction protein alpha 1	Homo sapiens	89-93
31284098-7	2019	By using a gap junction (GJ) inhibitor, 18beta-glycyrrhetinic acid, we demonstrated that Cx43 facilitated the delivery of siRNA into Cx43-expressing U87 MG cells.	18alpha-glycyrrhetinic acid	40-66	gap junction protein alpha 1	Homo sapiens	133-137
31390199-0	2019	Modification, Antitumor Activity, and Targeted PPARgamma Study of 18beta-Glycyrrhetinic Acid, an Important Active Ingredient of Licorice.	18alpha-glycyrrhetinic acid	66-92	peroxisome proliferator activated receptor gamma	Homo sapiens	47-56
30364936-7	2019	Furthermore, GRA pretreatment inhibited TLR2-activated GC cell proliferation, energy metabolism and carcinogenesis.	18alpha-glycyrrhetinic acid	13-16	toll like receptor 2	Homo sapiens	40-44
30364936-9	2019	Collectively, the results demonstrated that GRA inhibited gastric tumorigenesis through TLR2-accelerated energy metabolism, suggesting GRA as a promising therapeutic agency targeting TLR2 signaling in GC.	18alpha-glycyrrhetinic acid	44-47	toll like receptor 2	Homo sapiens	88-92
30364936-9	2019	Collectively, the results demonstrated that GRA inhibited gastric tumorigenesis through TLR2-accelerated energy metabolism, suggesting GRA as a promising therapeutic agency targeting TLR2 signaling in GC.	18alpha-glycyrrhetinic acid	44-47	toll like receptor 2	Homo sapiens	183-187
30364936-9	2019	Collectively, the results demonstrated that GRA inhibited gastric tumorigenesis through TLR2-accelerated energy metabolism, suggesting GRA as a promising therapeutic agency targeting TLR2 signaling in GC.	18alpha-glycyrrhetinic acid	135-138	toll like receptor 2	Homo sapiens	88-92
30364936-9	2019	Collectively, the results demonstrated that GRA inhibited gastric tumorigenesis through TLR2-accelerated energy metabolism, suggesting GRA as a promising therapeutic agency targeting TLR2 signaling in GC.	18alpha-glycyrrhetinic acid	135-138	toll like receptor 2	Homo sapiens	183-187
29973878-6	2018	For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB.	18alpha-glycyrrhetinic acid	37-46	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	57-62
30061734-0	2018	18beta-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.	18alpha-glycyrrhetinic acid	0-26	sirtuin 1	Homo sapiens	119-124
30061734-0	2018	18beta-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.	18alpha-glycyrrhetinic acid	0-26	nuclear receptor subfamily 1 group H member 4	Homo sapiens	125-128
30132504-5	2018	The inhibition of Cx43 with niflumic acid, flufenamic acid and 18-alpha-glycyrrhetinic acid in cultured human umbilical vein endothelial cells resulted in decreased phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and increased expression of Cav-1, as shown by western blot analysis.	18alpha-glycyrrhetinic acid	63-91	gap junction protein alpha 1	Homo sapiens	18-22
30132504-5	2018	The inhibition of Cx43 with niflumic acid, flufenamic acid and 18-alpha-glycyrrhetinic acid in cultured human umbilical vein endothelial cells resulted in decreased phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and increased expression of Cav-1, as shown by western blot analysis.	18alpha-glycyrrhetinic acid	63-91	mitogen-activated protein kinase 1	Homo sapiens	184-230
30132504-5	2018	The inhibition of Cx43 with niflumic acid, flufenamic acid and 18-alpha-glycyrrhetinic acid in cultured human umbilical vein endothelial cells resulted in decreased phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and increased expression of Cav-1, as shown by western blot analysis.	18alpha-glycyrrhetinic acid	63-91	caveolin 1	Homo sapiens	259-264
30150638-5	2018	Fluorescent dye uptake assays revealed that cells with Cx26-D50N had aberrantly high hemichannel activities, which were abolished by a hemichannel blocker, carbenoxolone and 18alpha-Glycyrrhetinic acid.	18alpha-glycyrrhetinic acid	174-201	gap junction protein beta 2	Homo sapiens	55-59
29973878-0	2018	18beta-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK-TRAF6 Interactions and NF-kappaB and MAPK Signaling Pathways.	18alpha-glycyrrhetinic acid	0-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	88-93
29973878-0	2018	18beta-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK-TRAF6 Interactions and NF-kappaB and MAPK Signaling Pathways.	18alpha-glycyrrhetinic acid	0-26	TNF receptor-associated factor 6	Mus musculus	108-113
29973878-6	2018	For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB.	18alpha-glycyrrhetinic acid	37-46	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	90-93
29973878-0	2018	18beta-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK-TRAF6 Interactions and NF-kappaB and MAPK Signaling Pathways.	18alpha-glycyrrhetinic acid	0-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	131-140
29973878-4	2018	Here, we for the first time explored the effects of 18beta-glycyrrhetinic acid (18beta-GA), a pentacyclic triterpenoid found in the Glycyrrhiza glabra L roots, on RANKL-induced osteoclastogenesis, osteoclast functions and signaling pathways in vitro and in vivo.	18alpha-glycyrrhetinic acid	52-78	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	163-168
29973878-6	2018	For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB.	18alpha-glycyrrhetinic acid	37-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-98
29973878-4	2018	Here, we for the first time explored the effects of 18beta-glycyrrhetinic acid (18beta-GA), a pentacyclic triterpenoid found in the Glycyrrhiza glabra L roots, on RANKL-induced osteoclastogenesis, osteoclast functions and signaling pathways in vitro and in vivo.	18alpha-glycyrrhetinic acid	80-89	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	163-168
29973878-6	2018	For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB.	18alpha-glycyrrhetinic acid	37-46	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	121-124
29973878-6	2018	For underlying molecular mechanisms, 18beta-GA inhibited RANKL-induced phosphorylation of p65, p50, and IkappaB, blocked p65 nuclear translocation and decreased the DNA-binding activity of NF-kappaB.	18alpha-glycyrrhetinic acid	37-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	189-198
29973878-10	2018	Overall, our results demonstrated that 18beta-GA inhibited RANKL-induced osteoclastogenesis by inhibiting RANK expression in preosteoclasts and blocking the binding of RANK and TRAF6 which lead to the inhibition of NF-kappaB and MAPK signaling pathways.	18alpha-glycyrrhetinic acid	39-48	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	59-64
29973878-10	2018	Overall, our results demonstrated that 18beta-GA inhibited RANKL-induced osteoclastogenesis by inhibiting RANK expression in preosteoclasts and blocking the binding of RANK and TRAF6 which lead to the inhibition of NF-kappaB and MAPK signaling pathways.	18alpha-glycyrrhetinic acid	39-48	TNF receptor-associated factor 6	Mus musculus	177-182
29973878-10	2018	Overall, our results demonstrated that 18beta-GA inhibited RANKL-induced osteoclastogenesis by inhibiting RANK expression in preosteoclasts and blocking the binding of RANK and TRAF6 which lead to the inhibition of NF-kappaB and MAPK signaling pathways.	18alpha-glycyrrhetinic acid	39-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	215-224
29677640-5	2018	Additionally, 18beta-GA suppressed NF-kappaB activation by inhibiting NF-kappaB/p65 and IkappaB-alpha phosphorylation and alleviated ROS overproduction in irradiated RAW264.7 macrophages.	18alpha-glycyrrhetinic acid	14-23	RELA proto-oncogene, NF-kB subunit	Homo sapiens	80-83
29921924-6	2018	We compared the roles of the ATF4/CHOP and IRE1alpha/XBP1s UPR pathways, which were both induced by GA.	18alpha-glycyrrhetinic acid	100-102	activating transcription factor 4	Homo sapiens	29-33
29921924-6	2018	We compared the roles of the ATF4/CHOP and IRE1alpha/XBP1s UPR pathways, which were both induced by GA.	18alpha-glycyrrhetinic acid	100-102	DNA damage inducible transcript 3	Homo sapiens	34-38
29921924-6	2018	We compared the roles of the ATF4/CHOP and IRE1alpha/XBP1s UPR pathways, which were both induced by GA.	18alpha-glycyrrhetinic acid	100-102	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	43-52
29921924-7	2018	The ATF4/CHOP cascade induced autophagy and was indispensable for the induction of apoptosis in GA-treated HCC cells.	18alpha-glycyrrhetinic acid	96-98	activating transcription factor 4	Homo sapiens	4-8
29921924-7	2018	The ATF4/CHOP cascade induced autophagy and was indispensable for the induction of apoptosis in GA-treated HCC cells.	18alpha-glycyrrhetinic acid	96-98	DNA damage inducible transcript 3	Homo sapiens	9-13
29921924-8	2018	In contrast, the IRE1alpha/XBP1s cascade protected HCC cells from apoptosis in vitro and in vivo induced by GA.	18alpha-glycyrrhetinic acid	108-110	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	17-26
29921924-10	2018	We concluded that pharmacological inhibition of autophagy or IRE1alpha may be of benefit to enhance the antitumor activity of GA.	18alpha-glycyrrhetinic acid	126-128	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	61-70
29677640-5	2018	Additionally, 18beta-GA suppressed NF-kappaB activation by inhibiting NF-kappaB/p65 and IkappaB-alpha phosphorylation and alleviated ROS overproduction in irradiated RAW264.7 macrophages.	18alpha-glycyrrhetinic acid	14-23	NFKB inhibitor alpha	Homo sapiens	88-101
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	18alpha-glycyrrhetinic acid	51-78	AKT serine/threonine kinase 1	Homo sapiens	124-127
29861658-8	2018	Moreover, the effect of GA on the regulation of mitochondrial ROS depends on the expression of uncoupling protein-2 (UCP-2).	18alpha-glycyrrhetinic acid	24-26	uncoupling protein 2	Homo sapiens	95-115
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	18alpha-glycyrrhetinic acid	51-78	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	143-152
29861658-8	2018	Moreover, the effect of GA on the regulation of mitochondrial ROS depends on the expression of uncoupling protein-2 (UCP-2).	18alpha-glycyrrhetinic acid	24-26	uncoupling protein 2	Homo sapiens	117-122
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	18alpha-glycyrrhetinic acid	51-78	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	153-157
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	18alpha-glycyrrhetinic acid	80-90	AKT serine/threonine kinase 1	Homo sapiens	124-127
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	18alpha-glycyrrhetinic acid	80-90	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	143-152
29444456-7	2018	Activation of AKT by SC79 or inhibition of GJIC by 18alpha-glycyrrhetinic acid (18alpha-GA) completely abolished Cd-induced AKT inhibition and IRE1alpha-ASK1 activation.	18alpha-glycyrrhetinic acid	80-90	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	153-157
29486954-0	2018	Discovery of 18beta-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.	18alpha-glycyrrhetinic acid	13-39	heat shock protein 90 alpha family class A member 1	Homo sapiens	85-90
29486954-0	2018	Discovery of 18beta-glycyrrhetinic acid conjugated aminobenzothiazole derivatives as Hsp90-Cdc37 interaction disruptors that inhibit cell migration and reverse drug resistance.	18alpha-glycyrrhetinic acid	13-39	cell division cycle 37, HSP90 cochaperone	Homo sapiens	91-96
29486954-1	2018	A series of 18beta-glycyrrhetinic acid (GA) conjugated aminobenzothiazole derivatives were designed, synthesized and evaluated for disruption activity of Hsp90-Cdc37 as well as the effects of in vitro cell migration.	18alpha-glycyrrhetinic acid	12-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	154-159
29259541-6	2017	However, simultaneous injection of GJ blocker, 18alpha-glycyrrhetinic acid, and Cx43 blocking peptide along with microinjection of HIV-infected cells prevented apoptosis in Cx43fl/fl mice, demonstrating the Cx43 is essential for HIV-induced bystander toxicity.	18alpha-glycyrrhetinic acid	47-74	gap junction protein, alpha 3	Mus musculus	173-177
28369869-3	2018	Two independent procedures to reduce GJIC, a pharmacological approach with GJIC inhibitors (18alpha-glycyrrhetinic acid and Gap27 peptide) and a molecular approach using small interfering RNA against Cx43, demonstrated that the presence of Cx43 and functional junctional channels are essential to the ability of hBMSCs to differentiate into osteoblasts in vitro.	18alpha-glycyrrhetinic acid	92-119	gap junction protein alpha 1	Homo sapiens	240-244
29098529-0	2018	18beta-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-alpha/ERK pathway.	18alpha-glycyrrhetinic acid	0-26	protein kinase C alpha	Homo sapiens	101-110
29098529-0	2018	18beta-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-alpha/ERK pathway.	18alpha-glycyrrhetinic acid	0-26	mitogen-activated protein kinase 1	Homo sapiens	111-114
29098529-5	2018	The results also showed that 18beta-GA inhibited ROS formation, PKC-alpha expression and the phosphorylation of ERK in a dose-dependent manner.	18alpha-glycyrrhetinic acid	29-38	protein kinase C alpha	Homo sapiens	64-73
29098529-5	2018	The results also showed that 18beta-GA inhibited ROS formation, PKC-alpha expression and the phosphorylation of ERK in a dose-dependent manner.	18alpha-glycyrrhetinic acid	29-38	mitogen-activated protein kinase 1	Homo sapiens	112-115
29098529-6	2018	In conclusion, this study revealed that 18beta-GA inhibits migration and invasion via the ROS/PKC-alpha/ERK signaling pathway in gastric cancer cells.	18alpha-glycyrrhetinic acid	40-49	protein kinase C alpha	Homo sapiens	94-103
29098529-6	2018	In conclusion, this study revealed that 18beta-GA inhibits migration and invasion via the ROS/PKC-alpha/ERK signaling pathway in gastric cancer cells.	18alpha-glycyrrhetinic acid	40-49	mitogen-activated protein kinase 1	Homo sapiens	104-107
28797028-12	2017	Pharmacological manipulation of 11beta-HSD2 activity by 18beta-glycyrrhetinic acid (GA) and silencing by specific siRNAs modulated the bioavailability of cortisol.	18alpha-glycyrrhetinic acid	56-82	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	32-43
28838831-0	2017	Conjugates of 18beta-glycyrrhetinic acid derivatives with 3-(1H-benzo[d]imidazol-2-yl)propanoic acid as Pin1 inhibitors displaying anti-prostate cancer ability.	18alpha-glycyrrhetinic acid	14-40	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	104-108
28838831-1	2017	Twenty-six conjugates of 18beta-glycyrrhetinic acid derivatives with 3-(1H-benzo[d]imidazol-2-yl)propanoic acid were designed and synthesized as Pin1 inhibitors.	18alpha-glycyrrhetinic acid	25-51	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	145-149
28939345-7	2017	However prophylactic treatment of GA diminished oxidative stress markers, TNF-alpha, NFkB expression and enhanced anti-oxidant status, down regulated apoptosis, recovered histopatholgical alterations in small intestine.	18alpha-glycyrrhetinic acid	34-36	tumor necrosis factor	Rattus norvegicus	74-83
28939345-7	2017	However prophylactic treatment of GA diminished oxidative stress markers, TNF-alpha, NFkB expression and enhanced anti-oxidant status, down regulated apoptosis, recovered histopatholgical alterations in small intestine.	18alpha-glycyrrhetinic acid	34-36	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	85-89
28797028-12	2017	Pharmacological manipulation of 11beta-HSD2 activity by 18beta-glycyrrhetinic acid (GA) and silencing by specific siRNAs modulated the bioavailability of cortisol.	18alpha-glycyrrhetinic acid	84-86	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	32-43
28933787-0	2017	Blocking autophagy enhances the apoptotic effect of 18beta-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation.	18alpha-glycyrrhetinic acid	52-78	mitogen-activated protein kinase 8	Homo sapiens	139-142
28933787-5	2017	Exposure to GA resulted in the activation of caspase-3, -8, and -9, indicating that GA induced apoptosis through both extrinsic and intrinsic pathways.	18alpha-glycyrrhetinic acid	12-14	caspase 3	Homo sapiens	45-66
28933787-5	2017	Exposure to GA resulted in the activation of caspase-3, -8, and -9, indicating that GA induced apoptosis through both extrinsic and intrinsic pathways.	18alpha-glycyrrhetinic acid	84-86	caspase 3	Homo sapiens	45-66
28933787-7	2017	The present findings showed that GA stimulated autophagy by inducing endoplasmic reticulum (ER) stress via the IRE1-JNK pathway.	18alpha-glycyrrhetinic acid	33-35	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	111-115
28933787-7	2017	The present findings showed that GA stimulated autophagy by inducing endoplasmic reticulum (ER) stress via the IRE1-JNK pathway.	18alpha-glycyrrhetinic acid	33-35	mitogen-activated protein kinase 8	Homo sapiens	116-119
28475285-12	2017	Furthermore, 18beta-glycyrrhetinic acids and mefloquine, which are gap junction inhibitors, attenuated senktide-induced Ca2+ oscillations in Kiss1-GFP cells.	18alpha-glycyrrhetinic acid	13-40	KiSS-1 metastasis-suppressor	Mus musculus	141-146
29089079-1	2017	Objective To investigate the mechanism of 18beta-glycyrrhetinic acid (GA) piperazine derivative A30 on the antiproliferation of hepatocellular carcinoma SMMC-7721 cells in vitro.	18alpha-glycyrrhetinic acid	42-68	immunoglobulin kappa variable 1-17	Homo sapiens	96-99
28410469-0	2017	18beta-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model.	18alpha-glycyrrhetinic acid	0-26	GATA binding protein 3	Mus musculus	141-147
28410469-0	2017	18beta-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model.	18alpha-glycyrrhetinic acid	0-26	signal transducer and activator of transcription 6	Mus musculus	149-154
28410469-0	2017	18beta-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model.	18alpha-glycyrrhetinic acid	0-26	forkhead box P3	Mus musculus	160-165
28637680-5	2017	These Ang-2 effects were suppressed by the MEGJ inhibitor 18alpha-glycyrrhetic acid (18-GA), Tie2 siRNA, or Cx43 siRNA.	18alpha-glycyrrhetinic acid	58-83	angiopoietin 2	Rattus norvegicus	6-11
28637680-5	2017	These Ang-2 effects were suppressed by the MEGJ inhibitor 18alpha-glycyrrhetic acid (18-GA), Tie2 siRNA, or Cx43 siRNA.	18alpha-glycyrrhetinic acid	85-90	angiopoietin 2	Rattus norvegicus	6-11
28414158-0	2017	Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARgamma and Nrf2: Protective effect of 18beta-Glycyrrhetinic acid.	18alpha-glycyrrhetinic acid	129-155	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	88-97
28414158-0	2017	Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARgamma and Nrf2: Protective effect of 18beta-Glycyrrhetinic acid.	18alpha-glycyrrhetinic acid	129-155	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
27122099-5	2016	Knockdown of nonchannel Cx43 (small interfering RNA [siRNA]) inhibited Cis-diamminedichloroplatinum (cisplatin)-induced cell death regardless of gap junction formation; however, a gap junction blocker, 18 alpha-glycyrrhetinic acid (18alpha-GA), showed inhibitory effect only under the junctional condition.	18alpha-glycyrrhetinic acid	232-242	gap junction protein alpha 1	Homo sapiens	24-28
27895804-0	2016	Erratum to: 18beta-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARgamma and Nrf2 upregulation.	18alpha-glycyrrhetinic acid	12-38	peroxisome proliferator activated receptor gamma	Homo sapiens	132-141
27895804-0	2016	Erratum to: 18beta-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARgamma and Nrf2 upregulation.	18alpha-glycyrrhetinic acid	12-38	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
27713126-0	2016	18beta-glycyrrhetinic acid suppresses gastric cancer by activation of miR-149-3p-Wnt-1 signaling.	18alpha-glycyrrhetinic acid	0-26	wingless-type MMTV integration site family, member 1	Mus musculus	81-86
27520483-0	2016	18alpha-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis.	18alpha-glycyrrhetinic acid	0-27	beclin 1	Homo sapiens	84-92
27520483-0	2016	18alpha-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis.	18alpha-glycyrrhetinic acid	0-27	BCL2 apoptosis regulator	Homo sapiens	93-98
27520483-9	2016	Treatment of cells by a pan-caspase inhibitor or a caspase-3 siRNA prevented a large portion of 18-GA mediated cytotoxicity, demonstrating that caspase-dependent apoptosis induction was responsible for most of the observed cytotoxicity.	18alpha-glycyrrhetinic acid	96-101	caspase 3	Homo sapiens	51-60
27626200-6	2016	Blocking of Cx43 channels by 18alpha-glycyrrhetinic acid decreases POMC-activation-induced adipose tissue beiging.	18alpha-glycyrrhetinic acid	29-56	gap junction protein alpha 1	Homo sapiens	12-16
27499091-0	2016	18beta-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.	18alpha-glycyrrhetinic acid	0-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-104
27499091-8	2016	18beta-GA, administered either before or after MTX, produced a significant amelioration of circulating kidney function markers, TNF-alpha, kidney lipid peroxidation, nitric oxide, and antioxidant defenses.	18alpha-glycyrrhetinic acid	0-9	tumor necrosis factor	Rattus norvegicus	128-137
27145860-0	2016	A potential adjuvant chemotherapeutics, 18beta-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2.	18alpha-glycyrrhetinic acid	40-66	bone morphogenetic protein 7	Mus musculus	132-137
27161375-5	2016	These results indicate that GA is effective in suppressing PRL hyperactivity caused by the blockade of dopamine D2 receptors.	18alpha-glycyrrhetinic acid	28-30	prolactin	Rattus norvegicus	59-62
27161375-1	2016	The purpose of this study was to examine the effects of 18beta-glycyrrhetinic acid (GA), a novel naturally derived agent, in suppressing prolactin (PRL) hyperactivity and reducing antipsychotic-induced hyperprolactinemia (hyperPRL) and the underlying mechanisms in in vitro and in vivo models.	18alpha-glycyrrhetinic acid	56-82	prolactin	Rattus norvegicus	148-151
27161375-1	2016	The purpose of this study was to examine the effects of 18beta-glycyrrhetinic acid (GA), a novel naturally derived agent, in suppressing prolactin (PRL) hyperactivity and reducing antipsychotic-induced hyperprolactinemia (hyperPRL) and the underlying mechanisms in in vitro and in vivo models.	18alpha-glycyrrhetinic acid	84-86	prolactin	Rattus norvegicus	148-151
27161375-2	2016	GA treatment for 24 h inhibited PRL synthesis and secretion in MMQ cells and cultured pituitary cells in a dose-dependent fashion; but this effect was not reproduced in GH3 cells that lack the expression of functional dopamine D2 receptors.	18alpha-glycyrrhetinic acid	0-2	prolactin	Rattus norvegicus	32-35
27161375-4	2016	GA also modulated the expression 5-HT1A and 5-HT2A receptors in both in vivo and in vitro models.	18alpha-glycyrrhetinic acid	0-2	5-hydroxytryptamine receptor 1A	Rattus norvegicus	33-45
27376261-1	2016	In this study we investigate the molecular mechanisms of caspases and mitochondria in the extrinsic and intrinsic signal apoptosis pathways in human leukemia HL-60 cells after in vitro exposure to 18alpha-glycyrrhetinic acid (18alpha-GA).	18alpha-glycyrrhetinic acid	197-224	caspase 8	Homo sapiens	57-65
27376261-1	2016	In this study we investigate the molecular mechanisms of caspases and mitochondria in the extrinsic and intrinsic signal apoptosis pathways in human leukemia HL-60 cells after in vitro exposure to 18alpha-glycyrrhetinic acid (18alpha-GA).	18alpha-glycyrrhetinic acid	226-236	caspase 8	Homo sapiens	57-65
27376261-3	2016	Cells treated with 18alpha-GA significantly inhibited cell proliferation and induced cell apoptosis in a dose-dependent manner, with an IC50 value of 100 muM at 48 h. The cell growth inhibition resulted in induction of apoptosis and decreased the mitochondria membrane potential (DeltaPsim) and increased caspase-8, -9 and -3 activities.	18alpha-glycyrrhetinic acid	19-29	caspase 8	Homo sapiens	305-325
27145860-0	2016	A potential adjuvant chemotherapeutics, 18beta-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2.	18alpha-glycyrrhetinic acid	40-66	histone deacetylase 2	Mus musculus	171-176
26386843-0	2015	18beta-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARgamma and Nrf2 upregulation.	18alpha-glycyrrhetinic acid	0-26	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	120-129
26900660-2	2016	In this study, 18beta-glycyrrhetinic acid (GA), the most abundant pentacyclic triterpenoid from natural source, was selected as a reference compound for the development of potent and specific inhibitors against hCE2.	18alpha-glycyrrhetinic acid	15-41	carboxylesterase 2	Homo sapiens	211-215
26900660-2	2016	In this study, 18beta-glycyrrhetinic acid (GA), the most abundant pentacyclic triterpenoid from natural source, was selected as a reference compound for the development of potent and specific inhibitors against hCE2.	18alpha-glycyrrhetinic acid	43-45	carboxylesterase 2	Homo sapiens	211-215
26900660-5	2016	Converting the 11-oxo-12-ene of GA to 12-diene moiety, and C-3 hydroxyl and C-30 carboxyl group to 3-O-beta-carboxypropionyl and ethyl ester respectively, led to a significant enhancement of the inhibitory effect on hCE2 and the selectivity over hCE1.	18alpha-glycyrrhetinic acid	32-34	carboxylesterase 2	Homo sapiens	216-220
26900660-5	2016	Converting the 11-oxo-12-ene of GA to 12-diene moiety, and C-3 hydroxyl and C-30 carboxyl group to 3-O-beta-carboxypropionyl and ethyl ester respectively, led to a significant enhancement of the inhibitory effect on hCE2 and the selectivity over hCE1.	18alpha-glycyrrhetinic acid	32-34	carboxylesterase 1	Homo sapiens	246-250
26565022-9	2016	FGF10 is expressed in salivary gland mesenchyme and regulates epithelial proliferation, and was shown to induce ERK1/2 phosphorylation in salivary epithelial cells, while ERK1/2 phosphorylation in HSY cells was dramatically inhibited by 18alpha-GA, a Cx43 peptide or siRNA.	18alpha-glycyrrhetinic acid	237-247	fibroblast growth factor 10	Homo sapiens	0-5
26386843-0	2015	18beta-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARgamma and Nrf2 upregulation.	18alpha-glycyrrhetinic acid	0-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
25691644-0	2015	Antileishmanial effect of 18beta-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation.	18alpha-glycyrrhetinic acid	26-52	mitogen-activated protein kinase 14	Homo sapiens	124-127
26279158-0	2015	Structural basis for 18-beta-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor.	18alpha-glycyrrhetinic acid	21-48	glyoxalase 1	Mus musculus	75-87
25691644-2	2015	For the GRA-mediated effect, the primary kinase responsible was found to be p38, and analysis of phosphorylation kinetics as well as studies with dominant-negative (DN) constructs revealed mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 as the immediate upstream regulators of p38.	18alpha-glycyrrhetinic acid	8-11	mitogen-activated protein kinase 14	Homo sapiens	76-79
25691644-2	2015	For the GRA-mediated effect, the primary kinase responsible was found to be p38, and analysis of phosphorylation kinetics as well as studies with dominant-negative (DN) constructs revealed mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 as the immediate upstream regulators of p38.	18alpha-glycyrrhetinic acid	8-11	mitogen-activated protein kinase kinase 3	Homo sapiens	189-230
25691644-2	2015	For the GRA-mediated effect, the primary kinase responsible was found to be p38, and analysis of phosphorylation kinetics as well as studies with dominant-negative (DN) constructs revealed mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 as the immediate upstream regulators of p38.	18alpha-glycyrrhetinic acid	8-11	mitogen-activated protein kinase kinase 3	Homo sapiens	232-236
25691644-2	2015	For the GRA-mediated effect, the primary kinase responsible was found to be p38, and analysis of phosphorylation kinetics as well as studies with dominant-negative (DN) constructs revealed mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 as the immediate upstream regulators of p38.	18alpha-glycyrrhetinic acid	8-11	mitogen-activated protein kinase kinase 6	Homo sapiens	242-246
25691644-2	2015	For the GRA-mediated effect, the primary kinase responsible was found to be p38, and analysis of phosphorylation kinetics as well as studies with dominant-negative (DN) constructs revealed mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 as the immediate upstream regulators of p38.	18alpha-glycyrrhetinic acid	8-11	mitogen-activated protein kinase 14	Homo sapiens	287-290
24613819-0	2014	18beta-Glycyrrhetinic acid suppresses TNF-alpha induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-kappaB pathway.	18alpha-glycyrrhetinic acid	0-26	nuclear factor kappa B subunit 1	Homo sapiens	155-164
26121859-0	2015	[Effects of 18beta-glycyrrhetinic Acid on the Expression of CCL11, AQP1 and EOS in Nasal Mucosa of Allergic Rhinitis Rats].	18alpha-glycyrrhetinic acid	12-38	C-C motif chemokine ligand 11	Rattus norvegicus	60-65
26121859-0	2015	[Effects of 18beta-glycyrrhetinic Acid on the Expression of CCL11, AQP1 and EOS in Nasal Mucosa of Allergic Rhinitis Rats].	18alpha-glycyrrhetinic acid	12-38	aquaporin 1	Rattus norvegicus	67-71
26121859-1	2015	OBJECTIVE: To investigate the effects of 18beta-glycyrrhetinic acid (GA) on the expression of eotaxin 1 (CCL11), aquaporin protein 1 (AQP1) and eosinophil (EOS) in nasal mucosa of allergic rhinitis (AR) rats.	18alpha-glycyrrhetinic acid	41-67	C-C motif chemokine ligand 11	Rattus norvegicus	105-110
26121859-1	2015	OBJECTIVE: To investigate the effects of 18beta-glycyrrhetinic acid (GA) on the expression of eotaxin 1 (CCL11), aquaporin protein 1 (AQP1) and eosinophil (EOS) in nasal mucosa of allergic rhinitis (AR) rats.	18alpha-glycyrrhetinic acid	41-67	aquaporin 1	Rattus norvegicus	134-138
26121859-1	2015	OBJECTIVE: To investigate the effects of 18beta-glycyrrhetinic acid (GA) on the expression of eotaxin 1 (CCL11), aquaporin protein 1 (AQP1) and eosinophil (EOS) in nasal mucosa of allergic rhinitis (AR) rats.	18alpha-glycyrrhetinic acid	69-71	C-C motif chemokine ligand 11	Rattus norvegicus	105-110
26121859-1	2015	OBJECTIVE: To investigate the effects of 18beta-glycyrrhetinic acid (GA) on the expression of eotaxin 1 (CCL11), aquaporin protein 1 (AQP1) and eosinophil (EOS) in nasal mucosa of allergic rhinitis (AR) rats.	18alpha-glycyrrhetinic acid	69-71	aquaporin 1	Rattus norvegicus	113-132
26121859-1	2015	OBJECTIVE: To investigate the effects of 18beta-glycyrrhetinic acid (GA) on the expression of eotaxin 1 (CCL11), aquaporin protein 1 (AQP1) and eosinophil (EOS) in nasal mucosa of allergic rhinitis (AR) rats.	18alpha-glycyrrhetinic acid	69-71	aquaporin 1	Rattus norvegicus	134-138
25048290-5	2015	Less than 10(-10) mol/L of BK induced vascular dilation BK-induced increase of vascular contractile response and calcium sensitivity was reduced by denudation of the endothelium, 18alpha-glycyrrhetic acid (an inhibitor of myoendothelial gap junction) and connexin 43 antisense oligodeoxynucleotide.	18alpha-glycyrrhetinic acid	179-204	gap junction protein, alpha 1	Rattus norvegicus	255-266
25043105-8	2014	To test this hypothesis, we treated the direct contact system with the gap junction inhibitor 18-alpha-glycyrrhetinic acid and found that Bglap expression was significantly inhibited.	18alpha-glycyrrhetinic acid	94-122	bone gamma-carboxyglutamate protein	Homo sapiens	138-143
25027936-1	2014	A series of glycosyl triazol linked 18beta-glycyrrhetinic acid (GA) derivatives have been synthesized using 1,3-dipolar cycloaddition reaction of per-O-acetylated glycosyl azide derivatives (4a-h) with propargyl ester of 18beta-glycyrrhetinic acid (GA) (2 and 3) following the concept of "Click chemistry".	18alpha-glycyrrhetinic acid	36-62	electron transfer flavoprotein subunit alpha	Homo sapiens	221-261
25027936-1	2014	A series of glycosyl triazol linked 18beta-glycyrrhetinic acid (GA) derivatives have been synthesized using 1,3-dipolar cycloaddition reaction of per-O-acetylated glycosyl azide derivatives (4a-h) with propargyl ester of 18beta-glycyrrhetinic acid (GA) (2 and 3) following the concept of "Click chemistry".	18alpha-glycyrrhetinic acid	64-66	electron transfer flavoprotein subunit alpha	Homo sapiens	221-261
24613819-0	2014	18beta-Glycyrrhetinic acid suppresses TNF-alpha induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-kappaB pathway.	18alpha-glycyrrhetinic acid	0-26	tumor necrosis factor	Homo sapiens	38-47
24613819-0	2014	18beta-Glycyrrhetinic acid suppresses TNF-alpha induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-kappaB pathway.	18alpha-glycyrrhetinic acid	0-26	matrix metallopeptidase 9	Homo sapiens	56-82
24613819-0	2014	18beta-Glycyrrhetinic acid suppresses TNF-alpha induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-kappaB pathway.	18alpha-glycyrrhetinic acid	0-26	vascular endothelial growth factor A	Homo sapiens	87-121
24613819-0	2014	18beta-Glycyrrhetinic acid suppresses TNF-alpha induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-kappaB pathway.	18alpha-glycyrrhetinic acid	0-26	AKT serine/threonine kinase 1	Homo sapiens	141-144
24613819-2	2014	Therefore, this study aimed to investigate the effects of GA on the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in various types of cancer cells.	18alpha-glycyrrhetinic acid	58-60	matrix metallopeptidase 9	Homo sapiens	82-108
24613819-2	2014	Therefore, this study aimed to investigate the effects of GA on the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in various types of cancer cells.	18alpha-glycyrrhetinic acid	58-60	matrix metallopeptidase 9	Homo sapiens	110-115
24613819-2	2014	Therefore, this study aimed to investigate the effects of GA on the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in various types of cancer cells.	18alpha-glycyrrhetinic acid	58-60	vascular endothelial growth factor A	Homo sapiens	121-155
24613819-2	2014	Therefore, this study aimed to investigate the effects of GA on the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in various types of cancer cells.	18alpha-glycyrrhetinic acid	58-60	vascular endothelial growth factor A	Homo sapiens	157-161
24613819-3	2014	We found that treatment with GA reduces tumor necrosis factor-alpha (TNF-alpha)-induced Matrigel invasion with few cytotoxic effects.	18alpha-glycyrrhetinic acid	29-31	tumor necrosis factor	Homo sapiens	40-67
24613819-3	2014	We found that treatment with GA reduces tumor necrosis factor-alpha (TNF-alpha)-induced Matrigel invasion with few cytotoxic effects.	18alpha-glycyrrhetinic acid	29-31	tumor necrosis factor	Homo sapiens	69-78
24613819-5	2014	In addition, GA inhibited inhibitory factor kappa B degradation, sustained nuclear factor-kappa B (NF-kappaB) subunits, p65 and p50, in the cytosol compartments, and consequently suppressed the TNF-alpha-induced DNA-binding activity and luciferase activity of NF-kappaB.	18alpha-glycyrrhetinic acid	13-15	nuclear factor kappa B subunit 1	Homo sapiens	75-97
24613819-5	2014	In addition, GA inhibited inhibitory factor kappa B degradation, sustained nuclear factor-kappa B (NF-kappaB) subunits, p65 and p50, in the cytosol compartments, and consequently suppressed the TNF-alpha-induced DNA-binding activity and luciferase activity of NF-kappaB.	18alpha-glycyrrhetinic acid	13-15	nuclear factor kappa B subunit 1	Homo sapiens	99-108
24613819-5	2014	In addition, GA inhibited inhibitory factor kappa B degradation, sustained nuclear factor-kappa B (NF-kappaB) subunits, p65 and p50, in the cytosol compartments, and consequently suppressed the TNF-alpha-induced DNA-binding activity and luciferase activity of NF-kappaB.	18alpha-glycyrrhetinic acid	13-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	120-123
24613819-5	2014	In addition, GA inhibited inhibitory factor kappa B degradation, sustained nuclear factor-kappa B (NF-kappaB) subunits, p65 and p50, in the cytosol compartments, and consequently suppressed the TNF-alpha-induced DNA-binding activity and luciferase activity of NF-kappaB.	18alpha-glycyrrhetinic acid	13-15	nuclear factor kappa B subunit 1	Homo sapiens	128-131
24613819-5	2014	In addition, GA inhibited inhibitory factor kappa B degradation, sustained nuclear factor-kappa B (NF-kappaB) subunits, p65 and p50, in the cytosol compartments, and consequently suppressed the TNF-alpha-induced DNA-binding activity and luciferase activity of NF-kappaB.	18alpha-glycyrrhetinic acid	13-15	tumor necrosis factor	Homo sapiens	194-203
24613819-5	2014	In addition, GA inhibited inhibitory factor kappa B degradation, sustained nuclear factor-kappa B (NF-kappaB) subunits, p65 and p50, in the cytosol compartments, and consequently suppressed the TNF-alpha-induced DNA-binding activity and luciferase activity of NF-kappaB.	18alpha-glycyrrhetinic acid	13-15	nuclear factor kappa B subunit 1	Homo sapiens	260-269
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	18alpha-glycyrrhetinic acid	143-145	tumor necrosis factor	Homo sapiens	32-41
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	18alpha-glycyrrhetinic acid	143-145	AKT serine/threonine kinase 1	Homo sapiens	88-91
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	18alpha-glycyrrhetinic acid	143-145	nuclear factor kappa B subunit 1	Homo sapiens	182-191
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	18alpha-glycyrrhetinic acid	143-145	AKT serine/threonine kinase 1	Homo sapiens	237-240
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	18alpha-glycyrrhetinic acid	143-145	matrix metallopeptidase 9	Homo sapiens	284-289
24613819-7	2014	Furthermore, phosphorylation of TNF-alpha-induced phosphatidyl-inositol 3 kinase (PI3K)/Akt was significantly downregulated in the presence of GA accompanying with the inhibition of NF-kappaB activity, and as presumed, the specific PI3K/Akt inhibitor LY294002 significantly decreased MMP-9 and VEGF expression as well as activity.	18alpha-glycyrrhetinic acid	143-145	vascular endothelial growth factor A	Homo sapiens	294-298
24613819-8	2014	These results suggest that GA operates as a potential anti-invasive agent by downregulating MMP-9 and VEGF via inhibition of PI3K/Akt-dependent NF-kappaB activity.	18alpha-glycyrrhetinic acid	27-29	matrix metallopeptidase 9	Homo sapiens	92-97
24613819-8	2014	These results suggest that GA operates as a potential anti-invasive agent by downregulating MMP-9 and VEGF via inhibition of PI3K/Akt-dependent NF-kappaB activity.	18alpha-glycyrrhetinic acid	27-29	vascular endothelial growth factor A	Homo sapiens	102-106
24613819-8	2014	These results suggest that GA operates as a potential anti-invasive agent by downregulating MMP-9 and VEGF via inhibition of PI3K/Akt-dependent NF-kappaB activity.	18alpha-glycyrrhetinic acid	27-29	AKT serine/threonine kinase 1	Homo sapiens	130-133
24613819-8	2014	These results suggest that GA operates as a potential anti-invasive agent by downregulating MMP-9 and VEGF via inhibition of PI3K/Akt-dependent NF-kappaB activity.	18alpha-glycyrrhetinic acid	27-29	nuclear factor kappa B subunit 1	Homo sapiens	144-153
24613819-9	2014	Taken together, GA might be an effective anti-invasive agent by suppressing PI3K/Akt-mediated NF-kappaB activity.	18alpha-glycyrrhetinic acid	16-18	AKT serine/threonine kinase 1	Homo sapiens	81-84
24613819-9	2014	Taken together, GA might be an effective anti-invasive agent by suppressing PI3K/Akt-mediated NF-kappaB activity.	18alpha-glycyrrhetinic acid	16-18	nuclear factor kappa B subunit 1	Homo sapiens	94-103
24578339-6	2014	Cx43 small interfering RNA and Cx43 hemichannel blocker 18-alpha-glycyrrhetinic acid completely prevented the CD38 silencing or 8-Bromo-cADPR-induced ATP release.	18alpha-glycyrrhetinic acid	56-84	gap junction protein, alpha 3	Mus musculus	0-4
24687644-5	2014	METHODS AND RESULTS: 18beta-glycyrrhetinic acid (18beta-GA) alleviated the effects of CB1R agonist, anandamide (AEA) on CB1R signaling in a concentration-dependent manner.	18alpha-glycyrrhetinic acid	21-47	cannabinoid receptor 1 (brain)	Mus musculus	86-90
24687644-5	2014	METHODS AND RESULTS: 18beta-glycyrrhetinic acid (18beta-GA) alleviated the effects of CB1R agonist, anandamide (AEA) on CB1R signaling in a concentration-dependent manner.	18alpha-glycyrrhetinic acid	21-47	cannabinoid receptor 1 (brain)	Mus musculus	120-124
24687644-5	2014	METHODS AND RESULTS: 18beta-glycyrrhetinic acid (18beta-GA) alleviated the effects of CB1R agonist, anandamide (AEA) on CB1R signaling in a concentration-dependent manner.	18alpha-glycyrrhetinic acid	49-58	cannabinoid receptor 1 (brain)	Mus musculus	86-90
24687644-5	2014	METHODS AND RESULTS: 18beta-glycyrrhetinic acid (18beta-GA) alleviated the effects of CB1R agonist, anandamide (AEA) on CB1R signaling in a concentration-dependent manner.	18alpha-glycyrrhetinic acid	49-58	cannabinoid receptor 1 (brain)	Mus musculus	120-124
24687644-9	2014	CONCLUSION: These results may provide a novel insight into the molecular mechanism involved in anti-adipogenic and anti-obesity effects of 18beta-GA by suppressing the activation of CB1R induced by AEA.	18alpha-glycyrrhetinic acid	139-148	cannabinoid receptor 1 (brain)	Mus musculus	182-186
24753074-6	2014	Gap junction blockade by two distinct GJIC inhibitors, 18alpha-glycyrrhetinic acid (AGA) and octanol (OcOH), suppressed proliferation and induced apoptosis in endometrial stromal cells, as manifested by reduced biomarkers of cell viability, increased TUNEL staining, caspase-3 activation, sub-G1 chromosomal DNA complement, as well as shortened telomere length.	18alpha-glycyrrhetinic acid	55-82	caspase 3	Homo sapiens	267-276
24578339-6	2014	Cx43 small interfering RNA and Cx43 hemichannel blocker 18-alpha-glycyrrhetinic acid completely prevented the CD38 silencing or 8-Bromo-cADPR-induced ATP release.	18alpha-glycyrrhetinic acid	56-84	gap junction protein, alpha 3	Mus musculus	31-35
24578339-6	2014	Cx43 small interfering RNA and Cx43 hemichannel blocker 18-alpha-glycyrrhetinic acid completely prevented the CD38 silencing or 8-Bromo-cADPR-induced ATP release.	18alpha-glycyrrhetinic acid	56-84	CD38 antigen	Mus musculus	110-114
24752617-8	2014	These results demonstrate that specific binding sites for GA exist in rat brain tissue, and suggest that the pharmacological actions of GA may be related to 11beta-HSD1 in astrocytes.	18alpha-glycyrrhetinic acid	58-60	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	157-168
24704497-9	2014	Furthermore, the Cx43 hemichannel opening could be blocked by the addition of 18beta-glycyrrhetinic acid, a Cx channel inhibitor, Cx43-targeting siRNA, or by withdrawal of FFSS stimulation.	18alpha-glycyrrhetinic acid	78-104	gap junction protein, alpha 1	Rattus norvegicus	17-21
24704497-9	2014	Furthermore, the Cx43 hemichannel opening could be blocked by the addition of 18beta-glycyrrhetinic acid, a Cx channel inhibitor, Cx43-targeting siRNA, or by withdrawal of FFSS stimulation.	18alpha-glycyrrhetinic acid	78-104	gap junction protein, alpha 1	Rattus norvegicus	130-134
24752617-8	2014	These results demonstrate that specific binding sites for GA exist in rat brain tissue, and suggest that the pharmacological actions of GA may be related to 11beta-HSD1 in astrocytes.	18alpha-glycyrrhetinic acid	136-138	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	157-168
24695790-0	2014	18beta-Glycyrrhetinic acid suppresses cell proliferation through inhibiting thromboxane synthase in non-small cell lung cancer.	18alpha-glycyrrhetinic acid	0-26	thromboxane A synthase 1	Homo sapiens	76-96
24695790-6	2014	However, 18beta-GA abolished the enhancement of cell proliferation induced by transfection of NCI-H23 with pCMV6-TxAS plasmid.	18alpha-glycyrrhetinic acid	9-18	thromboxane A synthase 1	Homo sapiens	113-117
23046406-8	2013	The response was dependent on the expression of Cx43 and inhibited by the GJ blocker 18alpha-glycyrrhetinic acid, suggesting Cx43 GJ-mediated activity.	18alpha-glycyrrhetinic acid	85-112	gap junction protein alpha 1	Homo sapiens	125-129
24162829-3	2014	GA also caused G0/G1 phase arrest, increased apoptosis rate and increased mitochondrial membrane permeabilization by suppressing the mitochondrial membrane potential and down-regulating a ratio of B cell lymphoma 2 (Bcl-2) and Bax.	18alpha-glycyrrhetinic acid	0-2	BCL2, apoptosis regulator	Rattus norvegicus	197-214
24162829-3	2014	GA also caused G0/G1 phase arrest, increased apoptosis rate and increased mitochondrial membrane permeabilization by suppressing the mitochondrial membrane potential and down-regulating a ratio of B cell lymphoma 2 (Bcl-2) and Bax.	18alpha-glycyrrhetinic acid	0-2	BCL2, apoptosis regulator	Rattus norvegicus	216-221
24162829-3	2014	GA also caused G0/G1 phase arrest, increased apoptosis rate and increased mitochondrial membrane permeabilization by suppressing the mitochondrial membrane potential and down-regulating a ratio of B cell lymphoma 2 (Bcl-2) and Bax.	18alpha-glycyrrhetinic acid	0-2	BCL2 associated X, apoptosis regulator	Rattus norvegicus	227-230
24162829-5	2014	Pretreatment with KN93, a CaMKII inhibitor, also abolished the GA activation of JNK and P38.	18alpha-glycyrrhetinic acid	63-65	mitogen-activated protein kinase 8	Rattus norvegicus	80-83
24162829-5	2014	Pretreatment with KN93, a CaMKII inhibitor, also abolished the GA activation of JNK and P38.	18alpha-glycyrrhetinic acid	63-65	mitogen activated protein kinase 14	Rattus norvegicus	88-91
24162829-7	2014	These results suggest that the anti-pituitary adenoma effect of GA is associated with its apoptotic actions by activating mitochondria-mediated ROS/mitogen-activated protein kinase pathways in particular CaMKII that may serve a linkage between ROS accumulation and the activation of JNK and P38.	18alpha-glycyrrhetinic acid	64-66	mitogen-activated protein kinase 8	Rattus norvegicus	283-286
24162829-7	2014	These results suggest that the anti-pituitary adenoma effect of GA is associated with its apoptotic actions by activating mitochondria-mediated ROS/mitogen-activated protein kinase pathways in particular CaMKII that may serve a linkage between ROS accumulation and the activation of JNK and P38.	18alpha-glycyrrhetinic acid	64-66	mitogen activated protein kinase 14	Rattus norvegicus	291-294
23954169-4	2014	Therefore, we targeted for neuroprotection activation of the redox sensitive transcription factor, nuclear erythroid-related factor 2 (Nrf2) by 18 alpha glycyrrhetinic acid to stimulate GSH synthesis through GCL.	18alpha-glycyrrhetinic acid	144-172	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-133
23954169-4	2014	Therefore, we targeted for neuroprotection activation of the redox sensitive transcription factor, nuclear erythroid-related factor 2 (Nrf2) by 18 alpha glycyrrhetinic acid to stimulate GSH synthesis through GCL.	18alpha-glycyrrhetinic acid	144-172	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
23954169-4	2014	Therefore, we targeted for neuroprotection activation of the redox sensitive transcription factor, nuclear erythroid-related factor 2 (Nrf2) by 18 alpha glycyrrhetinic acid to stimulate GSH synthesis through GCL.	18alpha-glycyrrhetinic acid	144-172	germ cell-less, spermatogenesis associated 1	Mus musculus	208-211
23707333-0	2013	18beta-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells.	18alpha-glycyrrhetinic acid	0-26	potassium voltage-gated channel subfamily A member 3	Homo sapiens	45-50
23826195-6	2013	Inhibition of 11beta-HSD2 by 11beta-HSD inhibitor 18beta-glycyrrhetinic acid or 11beta-HSD2 shRNA significantly increased cortisol-induced apoptosis in Jurkat cells.	18alpha-glycyrrhetinic acid	50-76	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	14-25
23438306-0	2013	18beta-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses.	18alpha-glycyrrhetinic acid	0-26	negative elongation factor complex member C/D, Th1l	Mus musculus	85-88
23454167-8	2013	Finally, pharmacological blockade of connexin hemichannels with 18beta-glycyrrhetinic acid, octanol and carbenoxolone inhibited the NAD(+)-mediated cell rescue of PARP-triggered cell death.	18alpha-glycyrrhetinic acid	64-90	poly(ADP-ribose) polymerase 1	Homo sapiens	163-167
23297309-7	2013	The difference in vasorelaxation between arteries with normal and elevated endothelial intracellular pH (pHi) was abolished by the gap junction inhibitors 18beta-glycyrrhetinic acid and carbenoxolone while other putative modulators of endothelium-derived hyperpolarisations - Ba(2+), ouabain, iberiotoxin, 8Br-cAMP and polyethylene glycol catalase - had no effect.	18alpha-glycyrrhetinic acid	155-181	glucose-6-phosphate isomerase 1	Mus musculus	105-108
24261979-8	2013	GA was identified to be the active component of the aqueous extract of licorice responsible for induction of UGT1A8 in the rat liver.	18alpha-glycyrrhetinic acid	0-2	UDP glucuronosyltransferase family 1 member A8	Rattus norvegicus	109-115
23792039-5	2013	The most prominent inhibitory effect on the tumor necrosis factor-alpha (TNF-alpha) production was observed with the administration of 18beta-glycyrrhetinic acid as an active metabolite of glycyrrhizin.	18alpha-glycyrrhetinic acid	135-161	tumor necrosis factor	Mus musculus	44-71
23792039-5	2013	The most prominent inhibitory effect on the tumor necrosis factor-alpha (TNF-alpha) production was observed with the administration of 18beta-glycyrrhetinic acid as an active metabolite of glycyrrhizin.	18alpha-glycyrrhetinic acid	135-161	tumor necrosis factor	Mus musculus	73-82
23792039-8	2013	Furthermore, the complex form of 18beta-glycyrrhetinic acid and hydroxypropyl gammacyclodextrin reduced mRNA expressions of TNF-alpha, interleukin (IL)-1beta, and IL-6, which was histologically confirmed in the improvement of indomethacin-induced small intestinal damage.	18alpha-glycyrrhetinic acid	33-59	tumor necrosis factor	Mus musculus	124-133
23792039-8	2013	Furthermore, the complex form of 18beta-glycyrrhetinic acid and hydroxypropyl gammacyclodextrin reduced mRNA expressions of TNF-alpha, interleukin (IL)-1beta, and IL-6, which was histologically confirmed in the improvement of indomethacin-induced small intestinal damage.	18alpha-glycyrrhetinic acid	33-59	interleukin 1 beta	Mus musculus	135-157
23792039-8	2013	Furthermore, the complex form of 18beta-glycyrrhetinic acid and hydroxypropyl gammacyclodextrin reduced mRNA expressions of TNF-alpha, interleukin (IL)-1beta, and IL-6, which was histologically confirmed in the improvement of indomethacin-induced small intestinal damage.	18alpha-glycyrrhetinic acid	33-59	interleukin 6	Mus musculus	163-167
23362936-10	2013	18alpha-GA also inhibited NF-kappaB DNA-binding activity.	18alpha-glycyrrhetinic acid	0-10	nuclear factor kappa B subunit 1	Homo sapiens	26-35
23042946-10	2012	Furthermore, inhibition of Hsd11b2 activity by 18beta-glycyrrhetinic acid resulted in elevated whole-body cortisol levels and preoptic area mRNA abundance of corticotropin-releasing factor and mineralocorticoid receptor.	18alpha-glycyrrhetinic acid	47-73	hydroxysteroid (11-beta) dehydrogenase 2	Danio rerio	27-34
23218403-0	2013	Glycyrrhizic acid and 18beta-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation.	18alpha-glycyrrhetinic acid	22-48	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-103
22865487-0	2012	18beta-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.	18alpha-glycyrrhetinic acid	0-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	39-44
22865487-6	2012	18beta-Glycyrrhetinic acid enhanced Hsp90 inhibitor-induced apoptosis-related protein activation, nuclear damage, and cell death.	18alpha-glycyrrhetinic acid	0-26	heat shock protein 90 alpha family class A member 1	Homo sapiens	36-41
22865487-7	2012	The results suggest that 18beta-glycyrrhetinic acid may potentiate the Hsp90 inhibition-induced apoptosis in ovarian carcinoma cell lines via the activation of the caspase-8- and Bid-dependent pathways and the mitochondria-mediated cell death pathway, leading to activation of caspases.	18alpha-glycyrrhetinic acid	25-51	heat shock protein 90 alpha family class A member 1	Homo sapiens	71-76
22865487-7	2012	The results suggest that 18beta-glycyrrhetinic acid may potentiate the Hsp90 inhibition-induced apoptosis in ovarian carcinoma cell lines via the activation of the caspase-8- and Bid-dependent pathways and the mitochondria-mediated cell death pathway, leading to activation of caspases.	18alpha-glycyrrhetinic acid	25-51	caspase 8	Homo sapiens	164-182
22865487-7	2012	The results suggest that 18beta-glycyrrhetinic acid may potentiate the Hsp90 inhibition-induced apoptosis in ovarian carcinoma cell lines via the activation of the caspase-8- and Bid-dependent pathways and the mitochondria-mediated cell death pathway, leading to activation of caspases.	18alpha-glycyrrhetinic acid	25-51	caspase 8	Homo sapiens	277-285
22212640-4	2012	Acute inhibition of Cx43 in rat left ventricular (LV) SSM by 18alpha glycyrrhetinic acid (GA) or Cx43 mimetic peptides (Cx43-MP) reduced ADP-stimulated complex I respiration and ATP generation.	18alpha-glycyrrhetinic acid	61-88	gap junction protein, alpha 1	Rattus norvegicus	20-24
22609834-0	2012	18beta-Glycyrrhetinic acid preferentially blocks late Na current generated by DeltaKPQ Nav1.5 channels.	18alpha-glycyrrhetinic acid	0-26	sodium voltage-gated channel alpha subunit 5	Homo sapiens	87-93
22150760-5	2012	In addition, laminin-111 increased the proliferation index through reduction of gap junctional intercellular communication (GJIC), which was confirmed by 18alpha-glycyrrhetinic acid (18alpha-GA).	18alpha-glycyrrhetinic acid	154-181	laminin B1	Mus musculus	13-24
22150760-5	2012	In addition, laminin-111 increased the proliferation index through reduction of gap junctional intercellular communication (GJIC), which was confirmed by 18alpha-glycyrrhetinic acid (18alpha-GA).	18alpha-glycyrrhetinic acid	183-193	laminin B1	Mus musculus	13-24
22609834-5	2012	RESULTS: Superfusion of 18beta-glycyrrhetinic acid (18beta-GA, 1-100 mumol/L) blocked both the peak current (I(Na,P)) and late current (I(Na,L)) generated by WT and DeltaKPQ Nav1.5 channels in a concentration-dependent manner, while 18alpha-glycyrrhetinic acid (18alpha-GA) at the same concentrations had no effects.	18alpha-glycyrrhetinic acid	24-50	sodium voltage-gated channel alpha subunit 5	Homo sapiens	174-180
22609834-5	2012	RESULTS: Superfusion of 18beta-glycyrrhetinic acid (18beta-GA, 1-100 mumol/L) blocked both the peak current (I(Na,P)) and late current (I(Na,L)) generated by WT and DeltaKPQ Nav1.5 channels in a concentration-dependent manner, while 18alpha-glycyrrhetinic acid (18alpha-GA) at the same concentrations had no effects.	18alpha-glycyrrhetinic acid	52-61	sodium voltage-gated channel alpha subunit 5	Homo sapiens	174-180
22811611-0	2012	18alpha-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Beta1/Smad signaling pathway in human and rat hepatic stellate cells.	18alpha-glycyrrhetinic acid	0-27	transforming growth factor beta 1	Homo sapiens	85-94
21732363-0	2012	18beta-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.	18alpha-glycyrrhetinic acid	0-26	AKT serine/threonine kinase 1	Homo sapiens	67-70
21732363-0	2012	18beta-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.	18alpha-glycyrrhetinic acid	0-26	forkhead box O3	Homo sapiens	71-77
21732363-0	2012	18beta-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.	18alpha-glycyrrhetinic acid	0-26	BCL2 like 11	Homo sapiens	78-81
21732363-6	2012	GRA induced an increase in Bax:Bcl-2 ratio along with a significant increase in the protein level of the BH3 protein Bim.	18alpha-glycyrrhetinic acid	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	27-30
21732363-6	2012	GRA induced an increase in Bax:Bcl-2 ratio along with a significant increase in the protein level of the BH3 protein Bim.	18alpha-glycyrrhetinic acid	0-3	BCL2 apoptosis regulator	Homo sapiens	31-36
21732363-6	2012	GRA induced an increase in Bax:Bcl-2 ratio along with a significant increase in the protein level of the BH3 protein Bim.	18alpha-glycyrrhetinic acid	0-3	BCL2 like 11	Homo sapiens	117-120
21732363-10	2012	Furthermore, GRA-induced activation and nuclear localization of FOXO3a was associated with a reduced activity of Akt kinase.	18alpha-glycyrrhetinic acid	13-16	forkhead box O3	Homo sapiens	64-70
21732363-10	2012	Furthermore, GRA-induced activation and nuclear localization of FOXO3a was associated with a reduced activity of Akt kinase.	18alpha-glycyrrhetinic acid	13-16	AKT serine/threonine kinase 1	Homo sapiens	113-116
22616823-5	2012	Levels of viral proteins VP2, VP6, and NSP2 in GRA treated cells were measured by immunoblot to determine if there was an effect of GRA treatment on the accumulation of viral protein.	18alpha-glycyrrhetinic acid	47-50	reticulon 2	Homo sapiens	39-43
22811611-0	2012	18alpha-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Beta1/Smad signaling pathway in human and rat hepatic stellate cells.	18alpha-glycyrrhetinic acid	0-27	SMAD family member 7	Homo sapiens	95-99
21851323-5	2012	Based on our analysis, gap junction inhibitors, 1-heptanol (2 mM) or 18-beta-glycyrrhetinic acid (30 muM), resulted in clear changes in beating cooperativity and the propagation pattern of impulses in the cardiomyocyte monolayer.	18alpha-glycyrrhetinic acid	69-96	latexin	Homo sapiens	101-104
22067259-8	2012	Blocking of endogenous cortisol catabolism in keratinocytes with the 11beta-HSD2 inhibitor 18beta-glycyrrhetinic acid mimicked the effect of exogenous administration of hydrocortisone and partially prevented the detrimental effects induced by pemphigus vulgaris sera.	18alpha-glycyrrhetinic acid	91-117	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	69-80
21909362-8	2011	We identified lkb1, an upstream kinase in the mTOR/Insulin pathway, and four novel drugs, Camptothecin, OH-Camptothecin, 18beta-Glycyrrhetinic acid, and Carbenoxolone, that were strong suppressors of mutant Huntingtin-induced neurotoxicity.	18alpha-glycyrrhetinic acid	121-147	huntingtin	Drosophila melanogaster	207-217
21644799-0	2011	Glycyrrhizic acid and 18beta-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-kappaB through PI3K p110delta and p110gamma inhibitions.	18alpha-glycyrrhetinic acid	22-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
21644799-0	2011	Glycyrrhizic acid and 18beta-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-kappaB through PI3K p110delta and p110gamma inhibitions.	18alpha-glycyrrhetinic acid	22-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Mus musculus	148-157
21644799-0	2011	Glycyrrhizic acid and 18beta-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-kappaB through PI3K p110delta and p110gamma inhibitions.	18alpha-glycyrrhetinic acid	22-48	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	162-171
21696969-0	2011	18beta-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells.	18alpha-glycyrrhetinic acid	0-26	tumor protein p53	Homo sapiens	121-124
21333315-5	2011	In addition, activated phosphorylation of ERK1/2 and p38 by LIPUS stimulation was diminished when cells were treated with a gap junction inhibitor 18beta-glycyrrhetinic acid (18beta).	18alpha-glycyrrhetinic acid	147-173	mitogen activated protein kinase 3	Rattus norvegicus	42-48
21333315-5	2011	In addition, activated phosphorylation of ERK1/2 and p38 by LIPUS stimulation was diminished when cells were treated with a gap junction inhibitor 18beta-glycyrrhetinic acid (18beta).	18alpha-glycyrrhetinic acid	147-173	mitogen activated protein kinase 14	Rattus norvegicus	53-56
22194991-4	2011	Analysis of MAP kinase pathways revealed that GRA caused strong activation of p38 and to a lesser extent, ERK in bone marrow-derived macrophages (BMDM).	18alpha-glycyrrhetinic acid	46-49	mitogen-activated protein kinase 14	Mus musculus	78-81
22194991-4	2011	Analysis of MAP kinase pathways revealed that GRA caused strong activation of p38 and to a lesser extent, ERK in bone marrow-derived macrophages (BMDM).	18alpha-glycyrrhetinic acid	46-49	mitogen-activated protein kinase 1	Mus musculus	106-109
22194991-5	2011	Almost complete abrogation of GRA-induced cytokine production in presence of specific inhibitors of p38 and ERK1/2 confirmed the involvement of these MAP kinases in GRA-mediated responses.	18alpha-glycyrrhetinic acid	30-33	mitogen-activated protein kinase 14	Mus musculus	100-103
22194991-5	2011	Almost complete abrogation of GRA-induced cytokine production in presence of specific inhibitors of p38 and ERK1/2 confirmed the involvement of these MAP kinases in GRA-mediated responses.	18alpha-glycyrrhetinic acid	30-33	mitogen-activated protein kinase 3	Mus musculus	108-114
22194991-5	2011	Almost complete abrogation of GRA-induced cytokine production in presence of specific inhibitors of p38 and ERK1/2 confirmed the involvement of these MAP kinases in GRA-mediated responses.	18alpha-glycyrrhetinic acid	165-168	mitogen-activated protein kinase 14	Mus musculus	100-103
22194991-5	2011	Almost complete abrogation of GRA-induced cytokine production in presence of specific inhibitors of p38 and ERK1/2 confirmed the involvement of these MAP kinases in GRA-mediated responses.	18alpha-glycyrrhetinic acid	165-168	mitogen-activated protein kinase 3	Mus musculus	108-114
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	0-3	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	58-62
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	0-3	mitogen-activated protein kinase 14	Mus musculus	169-172
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	0-3	mitogen-activated protein kinase 1	Mus musculus	174-177
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	0-3	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	182-186
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	115-118	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	58-62
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	115-118	mitogen-activated protein kinase 14	Mus musculus	169-172
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	115-118	mitogen-activated protein kinase 1	Mus musculus	174-177
22194991-6	2011	GRA induced mitogen- and stress-activated protein kinase (MSK1) activity in a time-dependent manner suggested that GRA-mediated NF-kappaB transactivation is mediated by p38, ERK and MSK1 pathway.	18alpha-glycyrrhetinic acid	115-118	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	182-186
20682015-0	2010	18beta-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-kappaB inactivation in interleukin-10-deficient mice.	18alpha-glycyrrhetinic acid	0-26	interleukin 10	Mus musculus	119-133
20868669-7	2010	The results suggest that 18beta-glycyrrhetinic acid may potentiate the apoptotic effects of trichostatin A against ovarian carcinoma cell lines by increasing the activation of the caspase-8-dependent pathway as well as the activation of the mitochondria-mediated cell death pathway, leading to activation of caspases.	18alpha-glycyrrhetinic acid	25-51	caspase 8	Homo sapiens	180-189
20868669-7	2010	The results suggest that 18beta-glycyrrhetinic acid may potentiate the apoptotic effects of trichostatin A against ovarian carcinoma cell lines by increasing the activation of the caspase-8-dependent pathway as well as the activation of the mitochondria-mediated cell death pathway, leading to activation of caspases.	18alpha-glycyrrhetinic acid	25-51	caspase 8	Homo sapiens	308-316
20682015-6	2010	RESULTS: 18beta-Glycyrrhetinic acid administered either prophylactically or therapeutically resulted in a dramatic reduction of infection-induced bone loss in interleukin-10-deficient mice, which are highly disease susceptible.	18alpha-glycyrrhetinic acid	9-35	interleukin 10	Mus musculus	159-173
20682015-8	2010	Rather, in glucocorticoid-free conditions, GA potently inhibited LPS-stimulated proinflammatory cytokine production and RANKL-stimulated osteoclastogenesis, both of which are dependent on nuclear factor-kappaB.	18alpha-glycyrrhetinic acid	43-45	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	120-125
20682015-10	2010	CONCLUSION: These findings indicate that GA inhibits periodontitis by inactivation of nuclear factor-kappaB in an interleukin-10- and glucocorticoid-independent fashion.	18alpha-glycyrrhetinic acid	41-43	interleukin 10	Mus musculus	114-128
20188775-7	2010	18-beta glycyrrhetinic acid (GA), a gap junction blocker, stimulated renin release dose-dependently and increased intracellular Ca(2+) in both Cx43-overexpressing cells and control cells.	18alpha-glycyrrhetinic acid	0-27	gap junction protein, alpha 3	Mus musculus	143-147
20681651-0	2010	Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation.	18alpha-glycyrrhetinic acid	22-48	AKT serine/threonine kinase 1	Homo sapiens	79-82
20681651-0	2010	Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation.	18alpha-glycyrrhetinic acid	22-48	glycogen synthase kinase 3 beta	Homo sapiens	83-91
20681651-0	2010	Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation.	18alpha-glycyrrhetinic acid	22-48	nuclear receptor subfamily 3 group C member 1	Homo sapiens	106-129
20681651-2	2010	We previously showed that GA and 18beta-glycyrrhetinic acid (18betaGA), found in licorice, can act as neuroprotective agents by promoting downstream PI3K/Akt signaling.	18alpha-glycyrrhetinic acid	33-59	AKT serine/threonine kinase 1	Homo sapiens	154-157
20681651-2	2010	We previously showed that GA and 18beta-glycyrrhetinic acid (18betaGA), found in licorice, can act as neuroprotective agents by promoting downstream PI3K/Akt signaling.	18alpha-glycyrrhetinic acid	61-69	AKT serine/threonine kinase 1	Homo sapiens	154-157
19460776-6	2009	Mitochondrial K(+) influx (PBFI fluorescence) was decreased in digitonin-permeabilized cardiomyocytes from Cx32 mutants compared with wild-type mice, and addition of the Cx43 hemichannel blocker 18alpha-glycyrrhetinic acid had an inhibitory effect on mitochondrial K(+) influx in wild-type cardiomyocytes, but not in cardiomyocytes from Cx32 mutants.	18alpha-glycyrrhetinic acid	195-222	gap junction protein, alpha 3	Mus musculus	170-174
19897483-10	2010	Taken together, our results suggest that GA exhibits antiinflammatory effects through inhibition of MIP-1alpha in a mouse model of acute P. acnes-induced inflammatory liver injury.	18alpha-glycyrrhetinic acid	41-43	chemokine (C-C motif) ligand 3	Mus musculus	100-110
19221124-11	2009	Because dINs drive CPG neuron firing and are critical in maintaining swimming, the weakening of dIN activity could account for the effects of 18-beta-GA on swimming.	18alpha-glycyrrhetinic acid	142-152	Axin	Drosophila melanogaster	8-11
19224363-5	2009	Glycyrrhizin and 18beta-glycyrrhetinic acid prevented the 7-ketocholesterol-induced mitochondrial damage, leading to caspase-3 activation and cell death.	18alpha-glycyrrhetinic acid	17-43	caspase 3	Rattus norvegicus	117-126
19105645-0	2009	Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway.	18alpha-glycyrrhetinic acid	49-75	AKT serine/threonine kinase 1	Rattus norvegicus	117-120
19429429-5	2009	18beta-glycyrrhetinic acid (GA), a metabolite of the natural product glycyrrhizin, is not selective and inhibits both 11beta-HSD1 and 11beta-HSD2.	18alpha-glycyrrhetinic acid	0-26	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	134-145
19429429-5	2009	18beta-glycyrrhetinic acid (GA), a metabolite of the natural product glycyrrhizin, is not selective and inhibits both 11beta-HSD1 and 11beta-HSD2.	18alpha-glycyrrhetinic acid	28-30	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	118-129
19429429-5	2009	18beta-glycyrrhetinic acid (GA), a metabolite of the natural product glycyrrhizin, is not selective and inhibits both 11beta-HSD1 and 11beta-HSD2.	18alpha-glycyrrhetinic acid	28-30	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	134-145
20157396-9	2008	Glycyrrhizin and 18beta-glycyrrhetinic acid may reduce the MPP(+) toxicity in PC12 cells by suppressing caspase-3 activation.	18alpha-glycyrrhetinic acid	17-43	caspase 3	Rattus norvegicus	104-113
18721818-8	2008	Results suggest that 18beta-glycyrrhetinic acid may cause cell death in SiHa cells by inducing the mitochondrial membrane permeability change, leading to cytochrome c release and caspase-3 activation.	18alpha-glycyrrhetinic acid	21-47	cytochrome c, somatic	Homo sapiens	154-166
18721818-8	2008	Results suggest that 18beta-glycyrrhetinic acid may cause cell death in SiHa cells by inducing the mitochondrial membrane permeability change, leading to cytochrome c release and caspase-3 activation.	18alpha-glycyrrhetinic acid	21-47	caspase 3	Homo sapiens	179-188
18094712-8	2008	Finally, we show that PEL cells extravasate through the endothelial barrier and that the specific tyrosine kinase inhibitor of VEGF receptors, PTK-787/ZK-222584, the anti-VEGF antibody, bevacizumab or the gap junction inhibitor 18-alpha-glycyrrhetinic acid, partially attenuate PEL cell extravasation.	18alpha-glycyrrhetinic acid	228-256	vascular endothelial growth factor A	Homo sapiens	127-131
18094712-8	2008	Finally, we show that PEL cells extravasate through the endothelial barrier and that the specific tyrosine kinase inhibitor of VEGF receptors, PTK-787/ZK-222584, the anti-VEGF antibody, bevacizumab or the gap junction inhibitor 18-alpha-glycyrrhetinic acid, partially attenuate PEL cell extravasation.	18alpha-glycyrrhetinic acid	228-256	vascular endothelial growth factor A	Homo sapiens	171-175
18789391-1	2008	18Beta-glycyrrhetinic acid (18beta-GA) regulates serine/threonine dephosphorylation of connexin43 (Cx43).	18alpha-glycyrrhetinic acid	0-26	gap junction protein, alpha 1	Rattus norvegicus	87-97
18789391-1	2008	18Beta-glycyrrhetinic acid (18beta-GA) regulates serine/threonine dephosphorylation of connexin43 (Cx43).	18alpha-glycyrrhetinic acid	0-26	gap junction protein, alpha 1	Rattus norvegicus	99-103
18789391-8	2008	We conclude that 18beta-GA induces Ser368 phosphorylation of Cx43 via PKCepsilon.	18alpha-glycyrrhetinic acid	17-26	gap junction protein, alpha 1	Rattus norvegicus	61-65
18599597-3	2008	Superfusion with the GJ blockers 18-alpha-glycyrrhetinic acid (AGA; 75 microM) or 18-beta-glycyrrhetinic acid (50 microM) abolished the TNF-alpha-induced increase in LAV and LPV; carbenoxolone (75 microM) or oleamide (100 microM) reduced LAV by 50 and 75%, respectively, and LPV to a lesser extent.	18alpha-glycyrrhetinic acid	33-61	tumor necrosis factor	Mus musculus	136-145
18599597-3	2008	Superfusion with the GJ blockers 18-alpha-glycyrrhetinic acid (AGA; 75 microM) or 18-beta-glycyrrhetinic acid (50 microM) abolished the TNF-alpha-induced increase in LAV and LPV; carbenoxolone (75 microM) or oleamide (100 microM) reduced LAV by 50 and 75%, respectively, and LPV to a lesser extent.	18alpha-glycyrrhetinic acid	63-66	tumor necrosis factor	Mus musculus	136-145
18599597-3	2008	Superfusion with the GJ blockers 18-alpha-glycyrrhetinic acid (AGA; 75 microM) or 18-beta-glycyrrhetinic acid (50 microM) abolished the TNF-alpha-induced increase in LAV and LPV; carbenoxolone (75 microM) or oleamide (100 microM) reduced LAV by 50 and 75%, respectively, and LPV to a lesser extent.	18alpha-glycyrrhetinic acid	82-109	tumor necrosis factor	Mus musculus	136-145
18452148-11	2008	CONCLUSION: GA significantly reduced FFA/HFD-induced hepatic lipotoxicity by stabilizing the integrity of lysosomes and mitochondria and inhibiting cathepsin B expression and enzyme activity.	18alpha-glycyrrhetinic acid	12-14	cathepsin B	Homo sapiens	148-159
17493801-0	2007	Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives.	18alpha-glycyrrhetinic acid	74-100	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	28-70
17493614-18	2007	The presence of 18alpha-glycyrrhetinic acid (AGA), an inhibitor of gap junctions, decreased Cx43 and Cx50 protein levels and gap junction plaque number.	18alpha-glycyrrhetinic acid	16-43	gap junction protein alpha 1	Homo sapiens	92-96
17493614-18	2007	The presence of 18alpha-glycyrrhetinic acid (AGA), an inhibitor of gap junctions, decreased Cx43 and Cx50 protein levels and gap junction plaque number.	18alpha-glycyrrhetinic acid	16-43	gap junction protein alpha 8	Homo sapiens	101-105
17493801-4	2007	Here we report the discovery and synthesis of some 18beta-glycyrrhetinic acid (18beta-GA) derivatives (2-5) and their inhibitory activities against rat hepatic11beta-HSD1 and rat renal 11beta-HSD2.	18alpha-glycyrrhetinic acid	51-77	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	152-170
17493801-4	2007	Here we report the discovery and synthesis of some 18beta-glycyrrhetinic acid (18beta-GA) derivatives (2-5) and their inhibitory activities against rat hepatic11beta-HSD1 and rat renal 11beta-HSD2.	18alpha-glycyrrhetinic acid	79-88	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	152-170
17372306-10	2007	The lipid accumulation and the mRNA levels of C/EBPalpha, peroxisome proliferator-activated receptor gamma, and glucose transporter 4 were markedly reduced in AGA-treated adipocytes.	18alpha-glycyrrhetinic acid	159-162	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	46-106
17346752-3	2007	Treatment of glycyrrhizin and 18beta-glycyrrhetinic acid attenuated the 3-morpholinosydnonime-induced mitochondrial damage, formation of reactive oxygen species and GSH depletion and revealed a maximal inhibitory effect at 10 and 1 muM, respectively; beyond these concentrations the inhibitory effect declined.	18alpha-glycyrrhetinic acid	30-56	latexin	Homo sapiens	232-235
17346752-5	2007	The results show that glycyrrhizin and 18beta-glycyrrhetinic acid seem to prevent the toxic effect of 3-morpholinosydnonime against lung epithelial cells by suppressing the mitochondrial permeability transition that leads to the release of cytochrome c and activation of caspase-3.	18alpha-glycyrrhetinic acid	39-65	cytochrome c, somatic	Homo sapiens	240-252
17346752-5	2007	The results show that glycyrrhizin and 18beta-glycyrrhetinic acid seem to prevent the toxic effect of 3-morpholinosydnonime against lung epithelial cells by suppressing the mitochondrial permeability transition that leads to the release of cytochrome c and activation of caspase-3.	18alpha-glycyrrhetinic acid	39-65	caspase 3	Homo sapiens	271-280
17327992-3	2007	Liquiritigenin and 18beta-glycyrrhetinic acid most potently inhibited the degranulation of RBL-2H3 cells induced by IgE with the antigen (DNP-HSA) and rat peritoneal mast cells induced by compound 48/80.	18alpha-glycyrrhetinic acid	19-45	RB transcriptional corepressor like 2	Rattus norvegicus	91-96
17982260-5	2007	Treatment of skeletal muscle cells with an inhibitor of connexin function, 18alpha-glycyrrhetinic acid (AGRA), resulted in a reduction in the number of MyoD-positive cells and complete inhibition of myotube formation, concomitantly with an increase in the number of C/EBPalpha-positive cells.	18alpha-glycyrrhetinic acid	75-102	myogenic differentiation 1	Homo sapiens	152-156
16983688-0	2007	18beta-glycyrrhetinic acid promotes src interaction with connexin43 in rat cardiomyocytes.	18alpha-glycyrrhetinic acid	0-26	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	36-39
16983688-0	2007	18beta-glycyrrhetinic acid promotes src interaction with connexin43 in rat cardiomyocytes.	18alpha-glycyrrhetinic acid	0-26	gap junction protein, alpha 1	Rattus norvegicus	57-67
16983688-5	2007	18beta-Glycyrrhetinic acid also induced an increase in the levels of phosphorylated Src, and this effect was prevented by PP2.	18alpha-glycyrrhetinic acid	0-26	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	84-87
16983688-6	2007	Immunoprecipitation using anti-Cx43 and anti-p-Src antibodies showed that 18beta-glycyrrhetinic acid increased the association between p-Src and Cx43 and induced tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	74-100	gap junction protein, alpha 1	Rattus norvegicus	31-35
16983688-6	2007	Immunoprecipitation using anti-Cx43 and anti-p-Src antibodies showed that 18beta-glycyrrhetinic acid increased the association between p-Src and Cx43 and induced tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	74-100	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	47-50
16983688-6	2007	Immunoprecipitation using anti-Cx43 and anti-p-Src antibodies showed that 18beta-glycyrrhetinic acid increased the association between p-Src and Cx43 and induced tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	74-100	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	137-140
16983688-6	2007	Immunoprecipitation using anti-Cx43 and anti-p-Src antibodies showed that 18beta-glycyrrhetinic acid increased the association between p-Src and Cx43 and induced tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	74-100	gap junction protein, alpha 1	Rattus norvegicus	145-149
16983688-6	2007	Immunoprecipitation using anti-Cx43 and anti-p-Src antibodies showed that 18beta-glycyrrhetinic acid increased the association between p-Src and Cx43 and induced tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	74-100	gap junction protein, alpha 1	Rattus norvegicus	145-149
16983688-7	2007	We conclude that the inhibitory effect of 18beta-glycyrrhetinic acid on GJIC in cardiomyocytes involves Src-mediated tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	42-68	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	104-107
16983688-7	2007	We conclude that the inhibitory effect of 18beta-glycyrrhetinic acid on GJIC in cardiomyocytes involves Src-mediated tyrosine phosphorylation of Cx43.	18alpha-glycyrrhetinic acid	42-68	gap junction protein, alpha 1	Rattus norvegicus	145-149
17982260-5	2007	Treatment of skeletal muscle cells with an inhibitor of connexin function, 18alpha-glycyrrhetinic acid (AGRA), resulted in a reduction in the number of MyoD-positive cells and complete inhibition of myotube formation, concomitantly with an increase in the number of C/EBPalpha-positive cells.	18alpha-glycyrrhetinic acid	75-102	CCAAT enhancer binding protein alpha	Homo sapiens	266-276
17038639-7	2006	After excluding lytic ATP release, we used pharmacological strategies to reveal a potential mechanism involved in PMN-dependent ATP release (eg, verapamil, dipyridamole, brefeldin A, 18-alpha-glycyrrhetinic acid, connexin-mimetic peptides).	18alpha-glycyrrhetinic acid	183-211	tubulin-specific chaperone E	Mus musculus	114-117
16328273-7	2006	Inhibition of connexin 43 with 18beta glycyrrhetinic acid and carbenoxolone, a glycyrrhetinic acid derivative, during formation of the SNAC tissue constructs disrupts the differentiation of NT2 cells.	18alpha-glycyrrhetinic acid	31-57	gap junction protein alpha 1	Homo sapiens	14-25
16948846-5	2006	Two of these four compounds, alpha-mangostin and 18-beta-glycyrrhetinic acid, activated NFkappaB and induced IL-8 secretion.	18alpha-glycyrrhetinic acid	49-76	nuclear factor kappa B subunit 1	Homo sapiens	88-96
16948846-5	2006	Two of these four compounds, alpha-mangostin and 18-beta-glycyrrhetinic acid, activated NFkappaB and induced IL-8 secretion.	18alpha-glycyrrhetinic acid	49-76	C-X-C motif chemokine ligand 8	Homo sapiens	109-113
16002718-0	2005	18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B.	18alpha-glycyrrhetinic acid	3-27	negative elongation factor complex member C/D, Th1l	Mus musculus	46-49
16002718-0	2005	18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B.	18alpha-glycyrrhetinic acid	3-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-173
15642733-7	2005	Induction of apoptosis by GCDC was also associated with activation of JNK, which was prevented by GA. Activation of caspase 9 and dissipation of mitochondrial membrane potential were prevented by GA but not GL.	18alpha-glycyrrhetinic acid	98-100	mitogen-activated protein kinase 8	Rattus norvegicus	70-73
16163844-5	2005	18beta-Glycyrrhetinic acid displaced 17beta-[3H]-estradiol from sex hormone-binding globulin but not from the estrogen receptor.	18alpha-glycyrrhetinic acid	0-26	sex hormone binding globulin	Homo sapiens	64-92
12684060-7	2003	Two inhibitors of gap junction communication, 18alpha-glycyrrhetinic acid (30 microM) and oleamide (100 microM), significantly inhibited PTH- and 1,25-(OH)(2)D(3)-stimulated osteoclastic pit formation.	18alpha-glycyrrhetinic acid	46-73	parathyroid hormone	Mus musculus	137-140
15140751-7	2004	18alpha-Glycyrrhetinic acid (18alpha-GA), a gap junction blocker, attenuated the inhibitory effect of CNP on the rate of pH(i) recovery, suggesting that NHE activity in both cell layers of the CE is coregulated.	18alpha-glycyrrhetinic acid	0-27	natriuretic peptide C	Homo sapiens	102-105
15140751-7	2004	18alpha-Glycyrrhetinic acid (18alpha-GA), a gap junction blocker, attenuated the inhibitory effect of CNP on the rate of pH(i) recovery, suggesting that NHE activity in both cell layers of the CE is coregulated.	18alpha-glycyrrhetinic acid	0-27	solute carrier family 9 member C1	Homo sapiens	153-156
15140751-7	2004	18alpha-Glycyrrhetinic acid (18alpha-GA), a gap junction blocker, attenuated the inhibitory effect of CNP on the rate of pH(i) recovery, suggesting that NHE activity in both cell layers of the CE is coregulated.	18alpha-glycyrrhetinic acid	29-39	natriuretic peptide C	Homo sapiens	102-105
15140751-7	2004	18alpha-Glycyrrhetinic acid (18alpha-GA), a gap junction blocker, attenuated the inhibitory effect of CNP on the rate of pH(i) recovery, suggesting that NHE activity in both cell layers of the CE is coregulated.	18alpha-glycyrrhetinic acid	29-39	solute carrier family 9 member C1	Homo sapiens	153-156
15457371-4	2004	Its sensitivity to extracellular Ca2+ and gap junction channel blockers (18alpha-glycyrrhetinic acid, palmitoleic acid, heptanol), and its absence in non-transfected HeLa cells suggested that it is carried by Cx45 hemichannels.	18alpha-glycyrrhetinic acid	73-100	gap junction protein gamma 1	Homo sapiens	209-213
12494995-4	2002	Dye coupling and Oct-3/4 expression were abolished with heptanol and 18beta- glycyrrhetinic acid, two gap junction blockers.	18alpha-glycyrrhetinic acid	69-96	POU domain, class 5, transcription factor 1	Mus musculus	17-24
12552127-6	2003	EDHF-dependent relaxation is concomitant with liberation of endothelial CNP; in the presence of the myoendothelial gap-junction inhibitor 18alpha-glycyrrhetinic acid or after endothelial denudation, CNP release and EDHF responses are profoundly suppressed.	18alpha-glycyrrhetinic acid	138-165	natriuretic peptide C	Homo sapiens	199-202
11579157-6	2001	Under perforated patch-clamp conditions, ET-1 evoked an oscillatory inward current at negative potentials in such cells in the presence of the gap junction disrupter 18alpha-glycyrrhetinic acid.	18alpha-glycyrrhetinic acid	166-193	endothelin 1	Rattus norvegicus	41-45
11997239-4	2002	IL-1beta produced a dose-dependent increase in MMP activity that was blocked by exposure to the gap junction inhibitors 18alpha-glycyrrhetinic acid and octanol for as few as 50 min.	18alpha-glycyrrhetinic acid	120-147	interleukin 1 beta	Homo sapiens	0-8
11904152-5	2002	Since iNOS transcription has been shown to be under the control of the transcription factor nuclear factor kappaB (NF-kappaB), the effects of GA on NF-kappaB activation were examined.	18alpha-glycyrrhetinic acid	142-144	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-157
11904152-6	2002	Transient expression assays with NF-kappaB binding sites linked to the luciferase gene revealed that the increased level of iNOS mRNA, induced by GA, was mediated by the NF-kappaB transcription factor complex.	18alpha-glycyrrhetinic acid	146-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
11904152-6	2002	Transient expression assays with NF-kappaB binding sites linked to the luciferase gene revealed that the increased level of iNOS mRNA, induced by GA, was mediated by the NF-kappaB transcription factor complex.	18alpha-glycyrrhetinic acid	146-148	nitric oxide synthase 2, inducible	Mus musculus	124-128
11904152-6	2002	Transient expression assays with NF-kappaB binding sites linked to the luciferase gene revealed that the increased level of iNOS mRNA, induced by GA, was mediated by the NF-kappaB transcription factor complex.	18alpha-glycyrrhetinic acid	146-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	170-179
11904152-7	2002	By using DNA fragments containing the NF-kappaB binding sequence, GA was shown to activate the protein/DNA binding of NF-kappaB to its cognate site, as measured by electrophoretic mobility shift assay.	18alpha-glycyrrhetinic acid	66-68	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	38-47
11904152-7	2002	By using DNA fragments containing the NF-kappaB binding sequence, GA was shown to activate the protein/DNA binding of NF-kappaB to its cognate site, as measured by electrophoretic mobility shift assay.	18alpha-glycyrrhetinic acid	66-68	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-127
11904152-8	2002	These results demonstrate that GA stimulates NO production and is able to up-regulate iNOS expression through NF-kappaB transactivation in macrophages.	18alpha-glycyrrhetinic acid	31-33	nitric oxide synthase 2, inducible	Mus musculus	86-90
11904152-8	2002	These results demonstrate that GA stimulates NO production and is able to up-regulate iNOS expression through NF-kappaB transactivation in macrophages.	18alpha-glycyrrhetinic acid	31-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
11772934-9	2002	The pro-proliferative effects of 11beta-HSD2 were abrogated by 18beta-glycyrrhetinic acid, an 11beta-HSD inhibitor, and in cells transfected with cDNA encoding inactive 11beta-HSD2.	18alpha-glycyrrhetinic acid	63-89	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	33-44
11668482-7	2001	The bystander effect in NP-18 Cx26 cells was also prevented by the long term inhibitor of GJIC, 18-alpha-glycyrrhetinic acid (AGA).	18alpha-glycyrrhetinic acid	96-124	gap junction protein beta 2	Homo sapiens	30-34
11668482-7	2001	The bystander effect in NP-18 Cx26 cells was also prevented by the long term inhibitor of GJIC, 18-alpha-glycyrrhetinic acid (AGA).	18alpha-glycyrrhetinic acid	126-129	gap junction protein beta 2	Homo sapiens	30-34
12220964-0	2002	Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression.	18alpha-glycyrrhetinic acid	28-54	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	115-134
12220964-6	2002	The effects of GA on the cytochrome P450 (P450) 2E1, the major isozyme involved in carbon tetrachloride bioactivation, were also investigated.	18alpha-glycyrrhetinic acid	15-17	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	25-51
12163339-5	2002	Responses to bradykinin were attenuated in the presence of the gap junction inhibitors 18-alpha-glycyrrhetinic acid (18-alpha GA, 100 micro M), carbenoxolone (100 micro M) and palmitoleic acid (50 micro M).	18alpha-glycyrrhetinic acid	87-115	kininogen 1	Homo sapiens	13-23
10523421-4	1999	The endothelium-dependent component of the responses was attenuated by the gap junction inhibitor 18alpha-glycyrrhetinic acid (18alpha-GA; 50 microM), and a synthetic connexin-mimetic peptide homologous to the extracellular Gap 27 sequence of connexin 43 (43Gap 27, SRPTEKTIFII; 300 microM).	18alpha-glycyrrhetinic acid	98-125	gap junction alpha-1 protein	Oryctolagus cuniculus	243-254
10523421-4	1999	The endothelium-dependent component of the responses was attenuated by the gap junction inhibitor 18alpha-glycyrrhetinic acid (18alpha-GA; 50 microM), and a synthetic connexin-mimetic peptide homologous to the extracellular Gap 27 sequence of connexin 43 (43Gap 27, SRPTEKTIFII; 300 microM).	18alpha-glycyrrhetinic acid	127-137	gap junction alpha-1 protein	Oryctolagus cuniculus	243-254
32890994-1	2020	A series of novel 18beta-glycyrrhetinic acid (GA) derivatives featuring an exocyclic alpha,beta-unsaturated carbonyl moiety in ring A were synthesized and evaluated for their antitumor activities.	18alpha-glycyrrhetinic acid	46-48	olfactory receptor family 2 subfamily F member 1B	Mus musculus	18-24
33031908-8	2020	Taken together, TOGA effectively prevents the support of TAMs from fueling tumorigenesis through a mechanism related to the NF-kappaB pathway, and it may be a promising GA-modified drug for the treatment of HCC.	18alpha-glycyrrhetinic acid	18-20	nuclear factor kappa B subunit 1	Homo sapiens	124-133
32890994-2	2020	Compounds 5c and 5l showed stronger cytotoxicity than other compounds and reported GA analogue CDODA-Me (methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate).	18alpha-glycyrrhetinic acid	83-85	olfactory receptor family 2 subfamily F member 1B	Mus musculus	131-137
34732147-5	2021	Two kinds of connexin43 (Cx43) channel inhibitors, 18-alpha-GA and Gap 27, were used to alter Cx43 channel function in U937 monocytes and HUVECs, respectively, to determine the effects of Cx43 channels on U937-HUVEC adhesion.	18alpha-glycyrrhetinic acid	51-62	gap junction protein alpha 1	Homo sapiens	94-98
34666184-0	2022	Peptide Conjugates of 18beta-Glycyrrhetinic Acid as Potent Inhibitors of alpha-Glucosidase and AGEs-Induced Oxidation.	18alpha-glycyrrhetinic acid	22-48	sucrase isomaltase (alpha-glucosidase)	Mus musculus	73-90
34117542-1	2021	This study was aimed at elucidating the protective effects of 18beta-glycyrrhetinic acid (18betaGA) against acrylamide (Acr)-induced cellular damage in diabetic rats.	18alpha-glycyrrhetinic acid	62-88	acrosin	Rattus norvegicus	120-123
34612013-13	2021	In addition, effective compounds that target CYP2E1, including 18beta-glycyrrhetinic acid, styrene, toluene, nicotine, m-xylene, p-xylene, and colchicine, were identified.	18alpha-glycyrrhetinic acid	63-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	45-51
34117542-1	2021	This study was aimed at elucidating the protective effects of 18beta-glycyrrhetinic acid (18betaGA) against acrylamide (Acr)-induced cellular damage in diabetic rats.	18alpha-glycyrrhetinic acid	90-98	acrosin	Rattus norvegicus	120-123
34117542-3	2021	Administration of 18betaGA alone increased GSH, GSH-PX, SOD, and CAT in both liver and kidneys.	18alpha-glycyrrhetinic acid	18-26	catalase	Rattus norvegicus	65-68
34271106-7	2021	(2) GA treatment up-regulated the expression and activity of NADPH oxidase and iNOS, and increased ROS/RNS productions (O2 -,  OH, NO and ONOO-) in the MDA-MB-231 cells; (3) GA down-regulated the expression of SLC7A11 of System Xc-, decreased glutathione (GSH) level and inhibited GPX activity.	18alpha-glycyrrhetinic acid	174-176	nitric oxide synthase 2	Homo sapiens	79-83
34271106-7	2021	(2) GA treatment up-regulated the expression and activity of NADPH oxidase and iNOS, and increased ROS/RNS productions (O2 -,  OH, NO and ONOO-) in the MDA-MB-231 cells; (3) GA down-regulated the expression of SLC7A11 of System Xc-, decreased glutathione (GSH) level and inhibited GPX activity.	18alpha-glycyrrhetinic acid	174-176	solute carrier family 7 member 11	Homo sapiens	210-217
34271106-7	2021	(2) GA treatment up-regulated the expression and activity of NADPH oxidase and iNOS, and increased ROS/RNS productions (O2 -,  OH, NO and ONOO-) in the MDA-MB-231 cells; (3) GA down-regulated the expression of SLC7A11 of System Xc-, decreased glutathione (GSH) level and inhibited GPX activity.	18alpha-glycyrrhetinic acid	4-6	nitric oxide synthase 2	Homo sapiens	79-83
34271106-7	2021	(2) GA treatment up-regulated the expression and activity of NADPH oxidase and iNOS, and increased ROS/RNS productions (O2 -,  OH, NO and ONOO-) in the MDA-MB-231 cells; (3) GA down-regulated the expression of SLC7A11 of System Xc-, decreased glutathione (GSH) level and inhibited GPX activity.	18alpha-glycyrrhetinic acid	4-6	solute carrier family 7 member 11	Homo sapiens	210-217
34271106-8	2021	Taken together, GA could promote the productions of ROS and RNS via activating NADPH oxidases and iNOS, and decreasing GSH and GPX activity, subsequently aggravating lipid peroxidation and triggering ferroptosis in triple-negative breast cancer cells.	18alpha-glycyrrhetinic acid	16-18	nitric oxide synthase 2	Homo sapiens	98-102
34853268-4	2021	Intravitreal injection of gap junction blockers (18beta-glycyrrhetinic acid and carbenoxolone) reduced the ACh-induced dilation of retinal arterioles.	18alpha-glycyrrhetinic acid	49-75	RAS p21 protein activator 1	Rattus norvegicus	26-29
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	101-105
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	helicase for meiosis 1	Homo sapiens	107-115
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	117-121
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	123-128
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	209-214
34439061-11	2021	Glycyrrhizin and its metabolite 18-beta-glycyrrhetinic acid have shown a strong binding affinity for MPro, helicase, RdRp, spike, and E-channel proteins, while a flavonoid Baicalin also strongly binds against PLpro and RdRp.	18alpha-glycyrrhetinic acid	32-59	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	219-223
35598524-0	2022	Nrf2-mediated liver protection by 18beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3beta pathway.	18alpha-glycyrrhetinic acid	34-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
35598524-0	2022	Nrf2-mediated liver protection by 18beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3beta pathway.	18alpha-glycyrrhetinic acid	34-60	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
35598524-0	2022	Nrf2-mediated liver protection by 18beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3beta pathway.	18alpha-glycyrrhetinic acid	34-60	glycogen synthase kinase 3 alpha	Rattus norvegicus	126-134
35598524-8	2022	GA also enhanced the activities and expressions of several antioxidant enzymes through upregulating nuclear factor-erythroid 2-related factor2 (Nrf2).	18alpha-glycyrrhetinic acid	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-142
35598524-8	2022	GA also enhanced the activities and expressions of several antioxidant enzymes through upregulating nuclear factor-erythroid 2-related factor2 (Nrf2).	18alpha-glycyrrhetinic acid	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
35598524-9	2022	Moreover, inhibition of Nrf2 blocked the hepatoprotective effect of GA against RTS intoxication.	18alpha-glycyrrhetinic acid	68-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-28
35598524-10	2022	Mechanistically, GA increased the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and enhanced glycogen synthase kinase 3 beta (GSK3beta) inhibitory phosphorylation at serine 9, thus promoting the nuclear accumulation of Nrf2 and activating its downstream targets.	18alpha-glycyrrhetinic acid	17-19	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	53-82
35598524-10	2022	Mechanistically, GA increased the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and enhanced glycogen synthase kinase 3 beta (GSK3beta) inhibitory phosphorylation at serine 9, thus promoting the nuclear accumulation of Nrf2 and activating its downstream targets.	18alpha-glycyrrhetinic acid	17-19	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
35598524-10	2022	Mechanistically, GA increased the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and enhanced glycogen synthase kinase 3 beta (GSK3beta) inhibitory phosphorylation at serine 9, thus promoting the nuclear accumulation of Nrf2 and activating its downstream targets.	18alpha-glycyrrhetinic acid	17-19	glycogen synthase kinase 3 beta	Rattus norvegicus	126-157
35598524-10	2022	Mechanistically, GA increased the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and enhanced glycogen synthase kinase 3 beta (GSK3beta) inhibitory phosphorylation at serine 9, thus promoting the nuclear accumulation of Nrf2 and activating its downstream targets.	18alpha-glycyrrhetinic acid	17-19	glycogen synthase kinase 3 alpha	Rattus norvegicus	159-167
35598524-10	2022	Mechanistically, GA increased the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and enhanced glycogen synthase kinase 3 beta (GSK3beta) inhibitory phosphorylation at serine 9, thus promoting the nuclear accumulation of Nrf2 and activating its downstream targets.	18alpha-glycyrrhetinic acid	17-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	252-256
35598524-11	2022	CONCLUSION: This study for the first time demonstrated that GA exerted protective effects against RTS-induced liver injury by potentiating the Nrf2-mediated antioxidant system through PI3K/Akt/GSK3beta pathway.	18alpha-glycyrrhetinic acid	60-62	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
35598524-11	2022	CONCLUSION: This study for the first time demonstrated that GA exerted protective effects against RTS-induced liver injury by potentiating the Nrf2-mediated antioxidant system through PI3K/Akt/GSK3beta pathway.	18alpha-glycyrrhetinic acid	60-62	AKT serine/threonine kinase 1	Rattus norvegicus	189-192
35598524-11	2022	CONCLUSION: This study for the first time demonstrated that GA exerted protective effects against RTS-induced liver injury by potentiating the Nrf2-mediated antioxidant system through PI3K/Akt/GSK3beta pathway.	18alpha-glycyrrhetinic acid	60-62	glycogen synthase kinase 3 alpha	Rattus norvegicus	193-201
34989920-14	2022	18beta-GA treatment inhibited the activation of NF-kappaB and the NLRP3 inflammasome, decreased ROS level and pulmonary inflammation, improved alveolar development, and increased the bodyweight of neonatal rats with hyperoxia exposure.	18alpha-glycyrrhetinic acid	0-9	NLR family, pyrin domain containing 3	Rattus norvegicus	66-71
35370657-0	2022	Liquorice Extract and 18beta-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation.	18alpha-glycyrrhetinic acid	22-48	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	151-166
35227979-4	2022	These compounds were screened by receptor chromatography with immobilized beta2-adrenoceptor (beta2-AR) and cysteinyl-leukotriene receptor (CysLT), whereby we obtained a derivative of 18beta-glycyrrhetinic acid (XC267) that specifically binds to the two receptors.	18alpha-glycyrrhetinic acid	184-210	adrenergic receptor, beta 2	Mus musculus	74-92
35227979-4	2022	These compounds were screened by receptor chromatography with immobilized beta2-adrenoceptor (beta2-AR) and cysteinyl-leukotriene receptor (CysLT), whereby we obtained a derivative of 18beta-glycyrrhetinic acid (XC267) that specifically binds to the two receptors.	18alpha-glycyrrhetinic acid	184-210	adenosine A2a receptor	Mus musculus	94-102
35624826-6	2022	The hepatoprotective effects of 18beta-Glycyrrhetinic acid in the present investigation correlated well with co-activation and possible interactions among Sirt, FXR, and Nrf2.	18alpha-glycyrrhetinic acid	32-58	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	161-164
35624826-6	2022	The hepatoprotective effects of 18beta-Glycyrrhetinic acid in the present investigation correlated well with co-activation and possible interactions among Sirt, FXR, and Nrf2.	18alpha-glycyrrhetinic acid	32-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	170-174
35415314-4	2023	18beta-glycyrrhetinic acid (GA) is an effective intracellular inhibitor of HMGB1, but of poor water solubility and dose-dependent toxicity.	18alpha-glycyrrhetinic acid	0-26	high mobility group box 1	Homo sapiens	75-80
35415314-4	2023	18beta-glycyrrhetinic acid (GA) is an effective intracellular inhibitor of HMGB1, but of poor water solubility and dose-dependent toxicity.	18alpha-glycyrrhetinic acid	28-30	high mobility group box 1	Homo sapiens	75-80
35370657-9	2022	Further mechanism study showed that GA inhibited activities of CYPs, especially CYP3A1, the major CYP isoform responsible for the metabolic activation of RTS in rats.	18alpha-glycyrrhetinic acid	36-38	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	80-86
35370657-9	2022	Further mechanism study showed that GA inhibited activities of CYPs, especially CYP3A1, the major CYP isoform responsible for the metabolic activation of RTS in rats.	18alpha-glycyrrhetinic acid	36-38	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	98-101
35370657-10	2022	Enzymatic kinetic study revealed a competitive inhibition of rat CYP3A1 by GA.	18alpha-glycyrrhetinic acid	75-77	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	65-71