PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33347911-4 2021 deltaTE-13" diminished AOM/DSS-increased GM-CSF and MCP-1, and deltaTE decreased IL-1beta. tocotrienol, delta 0-7 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 41-47 34932399-0 2022 Delta-tocotrienol enhances the antitumor effects of interferon alpha through ROS and Erk/MAPK signaling pathways in hepatocellular carcinoma cells. tocotrienol, delta 0-17 mitogen-activated protein kinase 1 Homo sapiens 85-88 34932399-6 2022 Combining delta-tocotrienol and IFN alpha enhanced the decrease in proliferating cell nuclear antigen (PCNA) and matrix metalloproteinases MMP-7 and MMP-9. tocotrienol, delta 10-27 proliferating cell nuclear antigen Homo sapiens 67-101 34932399-6 2022 Combining delta-tocotrienol and IFN alpha enhanced the decrease in proliferating cell nuclear antigen (PCNA) and matrix metalloproteinases MMP-7 and MMP-9. tocotrienol, delta 10-27 proliferating cell nuclear antigen Homo sapiens 103-107 34932399-6 2022 Combining delta-tocotrienol and IFN alpha enhanced the decrease in proliferating cell nuclear antigen (PCNA) and matrix metalloproteinases MMP-7 and MMP-9. tocotrienol, delta 10-27 matrix metallopeptidase 7 Homo sapiens 139-144 34932399-6 2022 Combining delta-tocotrienol and IFN alpha enhanced the decrease in proliferating cell nuclear antigen (PCNA) and matrix metalloproteinases MMP-7 and MMP-9. tocotrienol, delta 10-27 matrix metallopeptidase 9 Homo sapiens 149-154 34932399-8 2022 delta-tocotrienol induced Notch1 activation and changes in Erk and p38 MAPK signaling status. tocotrienol, delta 0-17 notch receptor 1 Homo sapiens 26-32 34932399-8 2022 delta-tocotrienol induced Notch1 activation and changes in Erk and p38 MAPK signaling status. tocotrienol, delta 0-17 mitogen-activated protein kinase 1 Homo sapiens 59-62 34002673-0 2021 delta-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis. tocotrienol, delta 0-17 microRNA 429 Homo sapiens 125-132 34002673-0 2021 delta-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis. tocotrienol, delta 0-17 zinc finger E-box binding homeobox 1 Homo sapiens 134-138 34002673-11 2021 Mechanistically, delta-TT exerts these effects on trophoblasts via downregulating miR-429 and upregulating ZEB1. tocotrienol, delta 17-25 microRNA 429 Homo sapiens 82-89 34002673-11 2021 Mechanistically, delta-TT exerts these effects on trophoblasts via downregulating miR-429 and upregulating ZEB1. tocotrienol, delta 17-25 zinc finger E-box binding homeobox 1 Homo sapiens 107-111 34520051-9 2021 In particular, we found that the proapoptotic activity of delta-TT correlated with mitochondrial ROS production and subsequent JNK and p38 activation. tocotrienol, delta 58-66 mitogen-activated protein kinase 8 Homo sapiens 127-130 34520051-9 2021 In particular, we found that the proapoptotic activity of delta-TT correlated with mitochondrial ROS production and subsequent JNK and p38 activation. tocotrienol, delta 58-66 mitogen-activated protein kinase 14 Homo sapiens 135-138 34297765-6 2021 A significant reduction in C-reactive protein levels (WMD: -0.52 mg/L, 95% CI: -0.73, -0.32, p < 0.001) following tocotrienols supplementation was observed, but this finding was attributed to a single study using delta-tocotrienols, not mixed tocotrienols. tocotrienol, delta 213-231 C-reactive protein Homo sapiens 27-45 34710615-3 2022 We have shown that the metabolites of delta-tocopherol (deltaT) and delta-tocotrienol (deltaTE), i.e., deltaT-13"-carboxychromanol (COOH) and deltaTE-13"-COOH, respectively, inhibit COX-1/-2 and 5-LOX activity, but the nature of how they inhibit 5-LOX is not clear. tocotrienol, delta 68-85 cytochrome c oxidase I, mitochondrial Rattus norvegicus 182-187 34710615-3 2022 We have shown that the metabolites of delta-tocopherol (deltaT) and delta-tocotrienol (deltaTE), i.e., deltaT-13"-carboxychromanol (COOH) and deltaTE-13"-COOH, respectively, inhibit COX-1/-2 and 5-LOX activity, but the nature of how they inhibit 5-LOX is not clear. tocotrienol, delta 68-85 lysyl oxidase Rattus norvegicus 197-200 34710615-3 2022 We have shown that the metabolites of delta-tocopherol (deltaT) and delta-tocotrienol (deltaTE), i.e., deltaT-13"-carboxychromanol (COOH) and deltaTE-13"-COOH, respectively, inhibit COX-1/-2 and 5-LOX activity, but the nature of how they inhibit 5-LOX is not clear. tocotrienol, delta 68-85 lysyl oxidase Rattus norvegicus 248-251 34710615-3 2022 We have shown that the metabolites of delta-tocopherol (deltaT) and delta-tocotrienol (deltaTE), i.e., deltaT-13"-carboxychromanol (COOH) and deltaTE-13"-COOH, respectively, inhibit COX-1/-2 and 5-LOX activity, but the nature of how they inhibit 5-LOX is not clear. tocotrienol, delta 87-94 cytochrome c oxidase I, mitochondrial Rattus norvegicus 182-187 34710615-3 2022 We have shown that the metabolites of delta-tocopherol (deltaT) and delta-tocotrienol (deltaTE), i.e., deltaT-13"-carboxychromanol (COOH) and deltaTE-13"-COOH, respectively, inhibit COX-1/-2 and 5-LOX activity, but the nature of how they inhibit 5-LOX is not clear. tocotrienol, delta 87-94 lysyl oxidase Rattus norvegicus 197-200 34710615-3 2022 We have shown that the metabolites of delta-tocopherol (deltaT) and delta-tocotrienol (deltaTE), i.e., deltaT-13"-carboxychromanol (COOH) and deltaTE-13"-COOH, respectively, inhibit COX-1/-2 and 5-LOX activity, but the nature of how they inhibit 5-LOX is not clear. tocotrienol, delta 87-94 lysyl oxidase Rattus norvegicus 248-251 26629059-0 2015 miR-429 mediates delta-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP. tocotrienol, delta 17-34 microRNA 429 Homo sapiens 0-7 26629059-0 2015 miR-429 mediates delta-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP. tocotrienol, delta 17-34 X-linked inhibitor of apoptosis Homo sapiens 105-109 26629059-3 2015 Here, we reported that microRNA-429 (miR-429) is up-regulated in two TNBC cell lines (MDA-MB-231 and MDA-MB-468), treated with delta-tocotrienol. tocotrienol, delta 127-144 microRNA 429 Homo sapiens 23-35 26629059-3 2015 Here, we reported that microRNA-429 (miR-429) is up-regulated in two TNBC cell lines (MDA-MB-231 and MDA-MB-468), treated with delta-tocotrienol. tocotrienol, delta 127-144 microRNA 429 Homo sapiens 37-44 26629059-4 2015 Inhibition of miR-429 may partially rescue the apoptosis induced by delta-tocotrienol in MDA-MB-231 cells. tocotrienol, delta 68-85 microRNA 429 Homo sapiens 14-21 26629059-7 2015 These results suggest that the activation of miR-429 by delta-tocotrienol may be an effective approach for the prevention and treatment of triple-negative breast cancer. tocotrienol, delta 56-73 microRNA 429 Homo sapiens 45-52 35563663-0 2022 Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for delta-Tocotrienol. tocotrienol, delta 123-140 AKT serine/threonine kinase 1 Homo sapiens 55-58 35563663-0 2022 Exploiting the Metabolic Consequences of PTEN Loss and Akt/Hexokinase 2 Hyperactivation in Prostate Cancer: A New Role for delta-Tocotrienol. tocotrienol, delta 123-140 hexokinase 2 Homo sapiens 59-71 35563663-4 2022 Herein, we demonstrated that delta-TT inhibits glucose uptake and lactate production in PTEN-deficient LNCaP and PC3 PCa cells, by specifically decreasing HK2 expression. tocotrienol, delta 29-37 hexokinase 2 Homo sapiens 155-158 35280867-11 2022 delta-Tocotrienol was superior to placebo in decreasing the GGT level. tocotrienol, delta 0-17 gamma-glutamyltransferase 1 Homo sapiens 60-63 35280867-21 2022 delta-Tocotrienol was superior to liraglutide in decreasing the GGT level. tocotrienol, delta 0-17 gamma-glutamyltransferase 1 Homo sapiens 64-67 34710615-8 2022 Using enzyme kinetics, we observed that deltaT-13"-COOH, deltaTE-13"-COOH and deltaTE competitively inhibited 5-LOX activity with Ki of 1.6, 0.8 and 2.2 microM, respectively. tocotrienol, delta 57-64 lysyl oxidase Rattus norvegicus 112-115 34710615-8 2022 Using enzyme kinetics, we observed that deltaT-13"-COOH, deltaTE-13"-COOH and deltaTE competitively inhibited 5-LOX activity with Ki of 1.6, 0.8 and 2.2 microM, respectively. tocotrienol, delta 78-85 lysyl oxidase Rattus norvegicus 112-115 34056642-8 2021 The results suggest that delta-tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. tocotrienol, delta 25-42 cyclin dependent kinase inhibitor 2A Homo sapiens 91-94 34056642-8 2021 The results suggest that delta-tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. tocotrienol, delta 25-42 cyclin dependent kinase 4 Homo sapiens 95-99 34056642-8 2021 The results suggest that delta-tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. tocotrienol, delta 25-42 cyclin D1 Homo sapiens 100-109 34056642-10 2021 Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of delta-tocotrienol; therefore, delta-tocotrienol triggers apoptosis in CNE1 cells through caspase-3 signaling. tocotrienol, delta 84-101 caspase 3 Homo sapiens 13-30 34056642-10 2021 Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of delta-tocotrienol; therefore, delta-tocotrienol triggers apoptosis in CNE1 cells through caspase-3 signaling. tocotrienol, delta 84-101 caspase 3 Homo sapiens 13-22 34056642-10 2021 Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of delta-tocotrienol; therefore, delta-tocotrienol triggers apoptosis in CNE1 cells through caspase-3 signaling. tocotrienol, delta 114-131 caspase 3 Homo sapiens 13-30 34056642-10 2021 Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of delta-tocotrienol; therefore, delta-tocotrienol triggers apoptosis in CNE1 cells through caspase-3 signaling. tocotrienol, delta 114-131 caspase 3 Homo sapiens 13-22 33347911-4 2021 deltaTE-13" diminished AOM/DSS-increased GM-CSF and MCP-1, and deltaTE decreased IL-1beta. tocotrienol, delta 0-7 chemokine (C-C motif) ligand 2 Mus musculus 52-57 33347911-4 2021 deltaTE-13" diminished AOM/DSS-increased GM-CSF and MCP-1, and deltaTE decreased IL-1beta. tocotrienol, delta 63-70 interleukin 1 alpha Mus musculus 81-89 31280345-11 2020 delta-TT prevention of oxidative damage was completely removed by combined treatment with the specific inhibitors of PI3K/AKT (LY294002) and Nrf2 (ML385). tocotrienol, delta 0-8 thymoma viral proto-oncogene 1 Mus musculus 122-125 32979761-7 2020 In primary microglia, delta-tocotrienol downregulated IL-1beta production, but TNF-alpha and IL-6 were not affected. tocotrienol, delta 22-39 interleukin 1 alpha Homo sapiens 54-62 31280345-11 2020 delta-TT prevention of oxidative damage was completely removed by combined treatment with the specific inhibitors of PI3K/AKT (LY294002) and Nrf2 (ML385). tocotrienol, delta 0-8 nuclear factor, erythroid derived 2, like 2 Mus musculus 141-145 31280345-12 2020 CONCLUSIONS: The delta-TT protective effect against oxidative damage in MC3T3-E1 cells is due to a reduction of intracellular ROS levels and an increase of the GSH/GSSG ratio, and involves an interaction between the PI3K/Akt-Nrf2 signaling pathways. tocotrienol, delta 17-25 thymoma viral proto-oncogene 1 Mus musculus 221-224 31280345-12 2020 CONCLUSIONS: The delta-TT protective effect against oxidative damage in MC3T3-E1 cells is due to a reduction of intracellular ROS levels and an increase of the GSH/GSSG ratio, and involves an interaction between the PI3K/Akt-Nrf2 signaling pathways. tocotrienol, delta 17-25 nuclear factor, erythroid derived 2, like 2 Mus musculus 225-229 32580548-5 2020 PCC 6803) and vte1 (from Arabidopsis thaliana) for the biosynthesis of delta-tocotrienol. tocotrienol, delta 71-88 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 14-18 32629979-3 2020 The ability of delta-TT to promote MC3T3-E1 cells migration is dependent on Akt phosphorylation detected by Western blotting and involves Wnt/beta-catenin signalling pathway activation. tocotrienol, delta 15-23 thymoma viral proto-oncogene 1 Mus musculus 76-79 32629979-3 2020 The ability of delta-TT to promote MC3T3-E1 cells migration is dependent on Akt phosphorylation detected by Western blotting and involves Wnt/beta-catenin signalling pathway activation. tocotrienol, delta 15-23 catenin (cadherin associated protein), beta 1 Mus musculus 142-154 32629979-4 2020 In fact, delta-TT increased beta-catenin transcriptional activity, measured using a Nano luciferase assay and pretreatment with procaine (2 microM), an inhibitor of the Wnt/beta-catenin signalling pathway, reducing the wound healing activity of delta-TT on MC3T3-E1 cells. tocotrienol, delta 9-17 catenin (cadherin associated protein), beta 1 Mus musculus 28-40 32629979-4 2020 In fact, delta-TT increased beta-catenin transcriptional activity, measured using a Nano luciferase assay and pretreatment with procaine (2 microM), an inhibitor of the Wnt/beta-catenin signalling pathway, reducing the wound healing activity of delta-TT on MC3T3-E1 cells. tocotrienol, delta 9-17 catenin (cadherin associated protein), beta 1 Mus musculus 173-185 32629979-4 2020 In fact, delta-TT increased beta-catenin transcriptional activity, measured using a Nano luciferase assay and pretreatment with procaine (2 microM), an inhibitor of the Wnt/beta-catenin signalling pathway, reducing the wound healing activity of delta-TT on MC3T3-E1 cells. tocotrienol, delta 245-253 catenin (cadherin associated protein), beta 1 Mus musculus 28-40 32629979-5 2020 Moreover, delta-TT treatment increased the expression of beta-catenin specific target genes, such as Osteocalcin and Bone Morphogenetic Protein-2, involved in osteoblast differentiation and migration, and increased alkaline phosphatase and collagen content, osteoblast differentiation markers. tocotrienol, delta 10-18 catenin (cadherin associated protein), beta 1 Mus musculus 57-69 32629979-5 2020 Moreover, delta-TT treatment increased the expression of beta-catenin specific target genes, such as Osteocalcin and Bone Morphogenetic Protein-2, involved in osteoblast differentiation and migration, and increased alkaline phosphatase and collagen content, osteoblast differentiation markers. tocotrienol, delta 10-18 bone gamma-carboxyglutamate protein 2 Mus musculus 101-112 32629979-5 2020 Moreover, delta-TT treatment increased the expression of beta-catenin specific target genes, such as Osteocalcin and Bone Morphogenetic Protein-2, involved in osteoblast differentiation and migration, and increased alkaline phosphatase and collagen content, osteoblast differentiation markers. tocotrienol, delta 10-18 bone morphogenetic protein 2 Mus musculus 117-145 32291146-0 2020 Deuteration of the farnesyl terminal methyl groups of delta-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production. tocotrienol, delta 54-71 colony stimulating factor 3 (granulocyte) Mus musculus 139-144 31367187-0 2019 Vitamin E delta-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs. tocotrienol, delta 10-27 TNF superfamily member 10 Homo sapiens 72-77 31620952-10 2019 The expression of differentiation marker genes including BMP-2 and VEGFalpha was stimulated dose dependently by d-delta-tocotrienol (0-25 mumol/L). tocotrienol, delta 112-131 bone morphogenetic protein 2 Mus musculus 57-62 31620952-10 2019 The expression of differentiation marker genes including BMP-2 and VEGFalpha was stimulated dose dependently by d-delta-tocotrienol (0-25 mumol/L). tocotrienol, delta 112-131 vascular endothelial growth factor A Mus musculus 67-76 31620952-11 2019 Concomitantly, Western blot analysis showed that d-delta-tocotrienol down-regulated HMG CoA reductase. tocotrienol, delta 49-68 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Mus musculus 84-101 31367187-0 2019 Vitamin E delta-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs. tocotrienol, delta 10-27 CASP8 and FADD like apoptosis regulator Homo sapiens 143-150 31102695-7 2019 Compared to lithocholic acid 3-oxidation, CYP3A-catalyzed testosterone 6beta-hydroxylation was inhibited to a lesser extent by alpha-tocotrienol, gamma-tocotrienol, delta-tocotrienol, and a tocotrienol-rich vitamin E mixture. tocotrienol, delta 165-182 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 42-47 30471562-2 2019 delta-Tocotrienol (deltaTE), a vitamin E form, has been shown to inhibit NF-kappaB, but the mechanism underlying this action is not clear. tocotrienol, delta 0-17 nuclear factor kappa B subunit 1 Homo sapiens 73-82 30871192-0 2019 Delta-Tocotrienol Modulates Glutamine Dependence by Inhibiting ASCT2 and LAT1 Transporters in Non-Small Cell Lung Cancer (NSCLC) Cells: A Metabolomic Approach. tocotrienol, delta 0-17 solute carrier family 1 member 5 Homo sapiens 63-68 30871192-0 2019 Delta-Tocotrienol Modulates Glutamine Dependence by Inhibiting ASCT2 and LAT1 Transporters in Non-Small Cell Lung Cancer (NSCLC) Cells: A Metabolomic Approach. tocotrienol, delta 0-17 solute carrier family 7 member 5 Homo sapiens 73-77 30871192-5 2019 This study aimed to validate the metabolic dysregulation of glutamine and its derivatives in NSCLC using cellular 1H-NMR metabolomic approach while exploring the mechanism of delta-tocotrienol (deltaT) on glutamine transporters, and mTOR pathway. tocotrienol, delta 194-200 mechanistic target of rapamycin kinase Homo sapiens 233-237 30471562-0 2019 Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides. tocotrienol, delta 10-27 tumor necrosis factor Homo sapiens 37-46 30471562-2 2019 delta-Tocotrienol (deltaTE), a vitamin E form, has been shown to inhibit NF-kappaB, but the mechanism underlying this action is not clear. tocotrienol, delta 19-26 nuclear factor kappa B subunit 1 Homo sapiens 73-82 30471562-0 2019 Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides. tocotrienol, delta 10-27 nuclear factor kappa B subunit 1 Homo sapiens 58-67 30471562-3 2019 In the present study, we show that deltaTE inhibited TNF-alpha-induced activation of NF-kappaB and LPS-stimulated IL-6 in a dose- and time-dependent manner in Raw 264.7 macrophages. tocotrienol, delta 35-42 tumor necrosis factor Homo sapiens 53-62 30471562-3 2019 In the present study, we show that deltaTE inhibited TNF-alpha-induced activation of NF-kappaB and LPS-stimulated IL-6 in a dose- and time-dependent manner in Raw 264.7 macrophages. tocotrienol, delta 35-42 nuclear factor kappa B subunit 1 Homo sapiens 85-94 30471562-0 2019 Vitamin E delta-tocotrienol inhibits TNF-alpha-stimulated NF-kappaB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides. tocotrienol, delta 10-27 TNF alpha induced protein 3 Homo sapiens 117-120 30471562-3 2019 In the present study, we show that deltaTE inhibited TNF-alpha-induced activation of NF-kappaB and LPS-stimulated IL-6 in a dose- and time-dependent manner in Raw 264.7 macrophages. tocotrienol, delta 35-42 interleukin 6 Homo sapiens 114-118 30471562-7 2019 In pursuit of the cause for A20 induction, we found that deltaTE treatment caused rapid and persistent elevation of dihydroceramides, while decreased ceramides initially but increased ceramides during prolonged treatment. tocotrienol, delta 57-64 TNF alpha induced protein 3 Homo sapiens 28-31 30471562-9 2019 Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects. tocotrienol, delta 13-20 TNF alpha induced protein 3 Homo sapiens 36-39 30471562-9 2019 Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects. tocotrienol, delta 13-20 nuclear factor kappa B subunit 1 Homo sapiens 58-67 30471562-9 2019 Importantly, deltaTE"s induction of A20 and inhibition of NF-kappaB activation were partially counteracted by myriocin, a potent inhibitor of de novo synthesis of sphingolipids, indicating a critical role of sphingolipid modulation in deltaTE-mediated effects. tocotrienol, delta 235-242 TNF alpha induced protein 3 Homo sapiens 36-39 30471562-10 2019 Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides. tocotrienol, delta 109-116 TNF alpha induced protein 3 Homo sapiens 47-50 30471562-10 2019 Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides. tocotrienol, delta 109-116 nuclear factor kappa B subunit 1 Homo sapiens 63-72 30471562-10 2019 Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides. tocotrienol, delta 109-116 nuclear factor kappa B subunit 1 Homo sapiens 126-135 30471562-10 2019 Since dihydroceramide has been shown to induce A20 and inhibit NF-kappaB in RAW cells, we conclude that that deltaTE inhibits NF-kappaB activation by enhancing its negative regulator A20 as a result of modulating sphingolipids especially elevation of dihydroceramides. tocotrienol, delta 109-116 TNF alpha induced protein 3 Homo sapiens 183-186 26779438-13 2015 Moreover, we have shown that delta-TT has antiproliferative effects on breast cancer cells independently of their ER status through the inhibition of HMGR. tocotrienol, delta 29-37 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 150-154 30634632-9 2019 Supplementations with delta-TCT and alpha-TOC alone (Grp.6-Grp.8) significantly increased (p < 0.05) the number of produced 2-cell embryos by 50%, 36%, and 41%, respectively, compared to control (Grp.1). tocotrienol, delta 22-31 gastrin releasing peptide Mus musculus 53-56 30634632-9 2019 Supplementations with delta-TCT and alpha-TOC alone (Grp.6-Grp.8) significantly increased (p < 0.05) the number of produced 2-cell embryos by 50%, 36%, and 41%, respectively, compared to control (Grp.1). tocotrienol, delta 22-31 gastrin releasing peptide Mus musculus 59-62 30634632-9 2019 Supplementations with delta-TCT and alpha-TOC alone (Grp.6-Grp.8) significantly increased (p < 0.05) the number of produced 2-cell embryos by 50%, 36%, and 41%, respectively, compared to control (Grp.1). tocotrienol, delta 22-31 gastrin releasing peptide Mus musculus 59-62 30031388-2 2018 Moreover, results of plasma total mRNAs after delta-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-alpha, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-gamma after post-treatment. tocotrienol, delta 46-63 tumor necrosis factor Homo sapiens 177-186 30031388-2 2018 Moreover, results of plasma total mRNAs after delta-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-alpha, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-gamma after post-treatment. tocotrienol, delta 46-63 vascular cell adhesion molecule 1 Homo sapiens 188-193 30031388-2 2018 Moreover, results of plasma total mRNAs after delta-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-alpha, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-gamma after post-treatment. tocotrienol, delta 46-63 intercellular adhesion molecule 1 Homo sapiens 251-256 30031388-2 2018 Moreover, results of plasma total mRNAs after delta-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-alpha, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-gamma after post-treatment. tocotrienol, delta 46-63 interferon gamma Homo sapiens 261-270 27461002-8 2016 In melanoma cells, delta-TT exerted its antitumor effect through activation of the PERK/p-eIF2alpha/ATF4/CHOP, IRE1alpha and caspase-4 ER stress-related branches. tocotrienol, delta 19-27 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 83-87 27461002-8 2016 In melanoma cells, delta-TT exerted its antitumor effect through activation of the PERK/p-eIF2alpha/ATF4/CHOP, IRE1alpha and caspase-4 ER stress-related branches. tocotrienol, delta 19-27 eukaryotic translation initiation factor 2A Homo sapiens 90-99 27461002-8 2016 In melanoma cells, delta-TT exerted its antitumor effect through activation of the PERK/p-eIF2alpha/ATF4/CHOP, IRE1alpha and caspase-4 ER stress-related branches. tocotrienol, delta 19-27 activating transcription factor 4 Homo sapiens 100-104 27461002-8 2016 In melanoma cells, delta-TT exerted its antitumor effect through activation of the PERK/p-eIF2alpha/ATF4/CHOP, IRE1alpha and caspase-4 ER stress-related branches. tocotrienol, delta 19-27 DNA damage inducible transcript 3 Homo sapiens 105-109 27461002-8 2016 In melanoma cells, delta-TT exerted its antitumor effect through activation of the PERK/p-eIF2alpha/ATF4/CHOP, IRE1alpha and caspase-4 ER stress-related branches. tocotrienol, delta 19-27 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 111-120 30100736-0 2018 Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-kappaB, uPA activator, and MMP-9. tocotrienol, delta 0-17 nuclear factor kappa B subunit 1 Homo sapiens 90-99 30100736-0 2018 Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-kappaB, uPA activator, and MMP-9. tocotrienol, delta 0-17 plasminogen activator, urokinase Homo sapiens 101-104 30100736-0 2018 Delta-tocotrienol inhibits non-small-cell lung cancer cell invasion via the inhibition of NF-kappaB, uPA activator, and MMP-9. tocotrienol, delta 0-17 matrix metallopeptidase 9 Homo sapiens 120-125 27396399-9 2016 For ICAM-1 protein expression, the most potent is delta-TCT followed by alpha-TCT. tocotrienol, delta 50-59 intercellular adhesion molecule 1 Homo sapiens 4-10 27773949-4 2016 The key step in the synthesis is oxidative olefin cleavage of delta-tocotrienol to afford the chroman core of 1 with retention of chirality at the C-2 stereocenter. tocotrienol, delta 62-79 complement C2 Homo sapiens 147-150 24294967-1 2013 We recently demonstrated that natural delta-tocotrienol (DT3) significantly enhanced survival in total-body irradiated (TBI) mice, and protected mouse bone marrow cells from radiation-induced damage through Erk activation-associated mTOR survival pathways. tocotrienol, delta 38-55 Eph receptor B2 Mus musculus 207-210 25815474-0 2015 Delta-tocotrienol suppresses radiation-induced microRNA-30 and protects mice and human CD34+ cells from radiation injury. tocotrienol, delta 0-17 CD34 molecule Homo sapiens 87-91 25815474-2 2015 Herein we further evaluated radiation-induced miR-30 expression and mechanisms of delta-tocotrienol (DT3), a radiation countermeasure candidate, for regulating miR-30 in a mouse model and human hematopoietic CD34+ cells. tocotrienol, delta 82-99 microRNA 297b Mus musculus 160-163 25815474-2 2015 Herein we further evaluated radiation-induced miR-30 expression and mechanisms of delta-tocotrienol (DT3), a radiation countermeasure candidate, for regulating miR-30 in a mouse model and human hematopoietic CD34+ cells. tocotrienol, delta 82-99 CD34 molecule Homo sapiens 208-212 26875492-3 2015 In this context, the present study was undertaken to check if annatto tocotrienol (main component delta-tocotrienol) could suppress cell growth in human prostate cancer (PC3, androgen-independent type) cells via the inhibition of Src and Stat3. tocotrienol, delta 98-115 proprotein convertase subtilisin/kexin type 1 Homo sapiens 170-173 26875492-3 2015 In this context, the present study was undertaken to check if annatto tocotrienol (main component delta-tocotrienol) could suppress cell growth in human prostate cancer (PC3, androgen-independent type) cells via the inhibition of Src and Stat3. tocotrienol, delta 98-115 signal transducer and activator of transcription 3 Homo sapiens 238-243 26523792-0 2016 Estrogen receptor-mediated effect of delta-tocotrienol prevents neurotoxicity and motor deficit in the MPTP mouse model of Parkinson"s disease. tocotrienol, delta 37-54 estrogen receptor 1 (alpha) Mus musculus 0-17 25849286-0 2015 delta-tocotrienol induces human bladder cancer cell growth arrest, apoptosis and chemosensitization through inhibition of STAT3 pathway. tocotrienol, delta 0-17 signal transducer and activator of transcription 3 Homo sapiens 122-127 24680613-0 2014 Anti-melanogenic effects of delta-tocotrienol are associated with tyrosinase-related proteins and MAPK signaling pathway in B16 melanoma cells. tocotrienol, delta 28-45 mitogen-activated protein kinase 1 Mus musculus 98-102 24486300-0 2014 Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor. tocotrienol, delta 28-45 colony stimulating factor 3 (granulocyte) Mus musculus 88-125 24294967-1 2013 We recently demonstrated that natural delta-tocotrienol (DT3) significantly enhanced survival in total-body irradiated (TBI) mice, and protected mouse bone marrow cells from radiation-induced damage through Erk activation-associated mTOR survival pathways. tocotrienol, delta 38-55 mechanistic target of rapamycin kinase Mus musculus 233-237 23274571-8 2013 The delta-tocotrienol analogs 10 and 38 inhibited the migration of the highly metastatic human breast cancer cell line MDA-MB-231 with IC(50) values of 1.3 and 1.5 muM, respectively, in the wound-healing assay. tocotrienol, delta 4-21 latexin Homo sapiens 164-167 23963802-0 2013 Vitamin E delta-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer. tocotrienol, delta 10-27 pancreatic and duodenal homeobox 1 Mus musculus 85-90 23963802-1 2013 Previous work has shown that vitamin E delta-tocotrienol (VEDT) prolongs survival and delays progression of pancreatic cancer in the LSL-Kras(G12D)(/+);Pdx-1-Cre mouse model of pancreatic cancer. tocotrienol, delta 39-56 pancreatic and duodenal homeobox 1 Mus musculus 152-157 23361894-0 2013 Mitochondrial-dependent anticancer activity of delta-tocotrienol and its synthetic derivatives in HER-2/neu overexpressing breast adenocarcinoma cells. tocotrienol, delta 47-64 erb-b2 receptor tyrosine kinase 2 Homo sapiens 98-107 23361894-1 2013 Anticancer activity and mitochondrial mechanism of the vitamin E form delta-tocotrienol (delta-T3) was investigated in HER-2/neu-overexpressing human SKBR3 and murine TUBO breast cancer cells. tocotrienol, delta 70-87 erb-b2 receptor tyrosine kinase 2 Homo sapiens 119-155 23302291-0 2013 Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E delta-tocotrienol. tocotrienol, delta 129-146 pancreatic and duodenal homeobox 1 Mus musculus 101-106 23302291-2 2013 Here, we tested the chemopreventive activity of delta-tocotrienol, a bioactive vitamin E derivative extracted from palm fruit, in the LSL-Kras(G12D/+);Pdx-1-Cre pancreatic cancer mouse model. tocotrienol, delta 48-65 Kirsten rat sarcoma viral oncogene homolog Mus musculus 138-142 23302291-2 2013 Here, we tested the chemopreventive activity of delta-tocotrienol, a bioactive vitamin E derivative extracted from palm fruit, in the LSL-Kras(G12D/+);Pdx-1-Cre pancreatic cancer mouse model. tocotrienol, delta 48-65 pancreatic and duodenal homeobox 1 Mus musculus 151-156 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 Kirsten rat sarcoma viral oncogene homolog Mus musculus 45-49 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 midkine Mus musculus 74-77 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 mitogen-activated protein kinase 1 Mus musculus 78-81 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 thymoma viral proto-oncogene 1 Mus musculus 88-91 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 102-105 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 BCL2-like 1 Mus musculus 118-124 23302291-8 2013 delta-Tocotrienol treatment inhibited mutant Kras-driven pathways such as MEK/ERK, PI3K/AKT and NF-kB/p65, as well as Bcl-xL and induced p27. tocotrienol, delta 0-17 cyclin-dependent kinase inhibitor 1B Mus musculus 137-140 23302291-9 2013 delta-Tocotrienol also induced biomarkers of apoptosis such as Bax and activated caspase 3 along with an increase in plasma levels of CK18. tocotrienol, delta 0-17 BCL2-associated X protein Mus musculus 63-66 23302291-9 2013 delta-Tocotrienol also induced biomarkers of apoptosis such as Bax and activated caspase 3 along with an increase in plasma levels of CK18. tocotrienol, delta 0-17 caspase 3 Mus musculus 81-90 23302291-9 2013 delta-Tocotrienol also induced biomarkers of apoptosis such as Bax and activated caspase 3 along with an increase in plasma levels of CK18. tocotrienol, delta 0-17 keratin 18 Mus musculus 134-138 23302291-10 2013 In summary, delta-tocotrienol"s ability to interfere with oncogenic Kras pathways coupled with the observed increase in median survival and significant delay in PanIN progression highlights the chemopreventative potential of delta-tocotrienol and warrants further investigation of this micronutrient in individuals at high risk for pancreatic cancer. tocotrienol, delta 12-29 Kirsten rat sarcoma viral oncogene homolog Mus musculus 68-72 23302291-10 2013 In summary, delta-tocotrienol"s ability to interfere with oncogenic Kras pathways coupled with the observed increase in median survival and significant delay in PanIN progression highlights the chemopreventative potential of delta-tocotrienol and warrants further investigation of this micronutrient in individuals at high risk for pancreatic cancer. tocotrienol, delta 225-242 Kirsten rat sarcoma viral oncogene homolog Mus musculus 68-72 23393547-0 2013 Vitamin E delta-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. tocotrienol, delta 10-27 dynactin subunit 6 Homo sapiens 36-39 23393547-0 2013 Vitamin E delta-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. tocotrienol, delta 10-27 cyclin dependent kinase inhibitor 1B Homo sapiens 40-44 23393547-7 2013 Furthermore, delta-tocotrienol induced p27(Kip1) mRNA expression but not its protein degradation. tocotrienol, delta 13-30 dynactin subunit 6 Homo sapiens 39-42 23393547-7 2013 Furthermore, delta-tocotrienol induced p27(Kip1) mRNA expression but not its protein degradation. tocotrienol, delta 13-30 cyclin dependent kinase inhibitor 1B Homo sapiens 43-47 23393547-8 2013 p27(Kip1) gene promoter activity was induced by delta-tocotrienol through the promoter"s E2F-1 binding site, and this activity was attenuated by E2F-1 depletion using E2F-1 small interfering RNA. tocotrienol, delta 48-65 dynactin subunit 6 Homo sapiens 0-3 23393547-3 2013 We also showed that delta-tocotrienol-induced growth inhibition occurred concomitantly with G(1) cell-cycle arrest and increased p27(Kip1) nuclear accumulation. tocotrienol, delta 20-37 dynactin subunit 6 Homo sapiens 129-132 23393547-8 2013 p27(Kip1) gene promoter activity was induced by delta-tocotrienol through the promoter"s E2F-1 binding site, and this activity was attenuated by E2F-1 depletion using E2F-1 small interfering RNA. tocotrienol, delta 48-65 cyclin dependent kinase inhibitor 1B Homo sapiens 4-8 23393547-3 2013 We also showed that delta-tocotrienol-induced growth inhibition occurred concomitantly with G(1) cell-cycle arrest and increased p27(Kip1) nuclear accumulation. tocotrienol, delta 20-37 cyclin dependent kinase inhibitor 1B Homo sapiens 133-137 23393547-9 2013 Finally, decreased proliferation, mediated by Ki67 and p27(Kip1) expression by delta-tocotrienol, was confirmed in vivo in a nude mouse xenograft pancreatic cancer model. tocotrienol, delta 79-96 cyclin-dependent kinase inhibitor 1B Mus musculus 55-58 23393547-9 2013 Finally, decreased proliferation, mediated by Ki67 and p27(Kip1) expression by delta-tocotrienol, was confirmed in vivo in a nude mouse xenograft pancreatic cancer model. tocotrienol, delta 79-96 cyclin-dependent kinase inhibitor 1B Mus musculus 59-63 23393547-5 2013 Furthermore, delta-tocotrienol inactivated RAF-MEK-ERK signaling, a pathway known to suppress p27(Kip1) expression. tocotrienol, delta 13-30 zinc fingers and homeoboxes 2 Homo sapiens 43-46 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 80-97 dynactin subunit 6 Homo sapiens 50-53 23393547-5 2013 Furthermore, delta-tocotrienol inactivated RAF-MEK-ERK signaling, a pathway known to suppress p27(Kip1) expression. tocotrienol, delta 13-30 mitogen-activated protein kinase kinase 7 Homo sapiens 47-50 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 80-97 cyclin dependent kinase inhibitor 1B Homo sapiens 54-58 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 80-97 dynactin subunit 6 Homo sapiens 169-172 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 80-97 cyclin dependent kinase inhibitor 1B Homo sapiens 173-177 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 198-215 dynactin subunit 6 Homo sapiens 50-53 23393547-10 2013 Our findings reveal a new mechanism, dependent on p27(Kip1) induction, by which delta-tocotrienol can inhibit proliferation in PDCA cells, providing a new rationale for p27(Kip1) as a biomarker for delta-tocotrienol efficacy in pancreatic cancer prevention and therapy. tocotrienol, delta 198-215 cyclin dependent kinase inhibitor 1B Homo sapiens 173-177 23393547-5 2013 Furthermore, delta-tocotrienol inactivated RAF-MEK-ERK signaling, a pathway known to suppress p27(Kip1) expression. tocotrienol, delta 13-30 mitogen-activated protein kinase 1 Homo sapiens 51-54 23393547-5 2013 Furthermore, delta-tocotrienol inactivated RAF-MEK-ERK signaling, a pathway known to suppress p27(Kip1) expression. tocotrienol, delta 13-30 dynactin subunit 6 Homo sapiens 94-97 23393547-5 2013 Furthermore, delta-tocotrienol inactivated RAF-MEK-ERK signaling, a pathway known to suppress p27(Kip1) expression. tocotrienol, delta 13-30 cyclin dependent kinase inhibitor 1B Homo sapiens 98-102 22185406-2 2011 We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, delta-tocotrienol, and riboflavin) can inhibit lipopolysaccharide (LPS)-induced NO production in vitro by RAW 264.7 cells and by thioglycolate-elicited peritoneal macrophages derived from four strains of mice (C57BL/6, BALB/c, LMP7/MECL-1(-/-) and PPAR-alpha(-/-) knockout mice). tocotrienol, delta 91-108 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Mus musculus 318-322 22438124-0 2012 Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells. tocotrienol, delta 0-17 notch receptor 1 Homo sapiens 29-36 22438124-0 2012 Delta-tocotrienol suppresses Notch-1 pathway by upregulating miR-34a in nonsmall cell lung cancer cells. tocotrienol, delta 0-17 microRNA 34a Homo sapiens 61-68 22438124-3 2012 In our study, using miRNA microarray, we observed that downregulation of the Notch-1 pathway, by delta-tocotrienol, correlated with upregulation of miR-34a, in nonsmall cell lung cancer cells (NSCLC). tocotrienol, delta 97-114 notch receptor 1 Homo sapiens 77-84 22438124-3 2012 In our study, using miRNA microarray, we observed that downregulation of the Notch-1 pathway, by delta-tocotrienol, correlated with upregulation of miR-34a, in nonsmall cell lung cancer cells (NSCLC). tocotrienol, delta 97-114 microRNA 34a Homo sapiens 148-155 22438124-6 2012 Our findings suggest that delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit NSCLC cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. tocotrienol, delta 26-43 microRNA 34a Homo sapiens 71-78 22753722-0 2012 Delta-tocotrienol augments cisplatin-induced suppression of non-small cell lung cancer cells via inhibition of the Notch-1 pathway. tocotrienol, delta 0-17 notch receptor 1 Homo sapiens 115-122 22753722-2 2012 Previously, we demonstrated that delta-tocotrienol inhibits NSCLC cell proliferation, invasion and induces apoptosis by down-regulation of the Notch-1 signaling pathway. tocotrienol, delta 33-50 notch receptor 1 Homo sapiens 143-150 22753722-6 2012 These results suggest that down-regulation of Notch-1, via inhibition of NF-kappaB signaling pathways by delta-tocotrienol and cisplatin, in combination, could provide a potential novel approach for tumor arrest in NSCLC, while lowering the effective dose of cisplatin. tocotrienol, delta 105-122 notch receptor 1 Homo sapiens 46-53 22753722-6 2012 These results suggest that down-regulation of Notch-1, via inhibition of NF-kappaB signaling pathways by delta-tocotrienol and cisplatin, in combination, could provide a potential novel approach for tumor arrest in NSCLC, while lowering the effective dose of cisplatin. tocotrienol, delta 105-122 nuclear factor kappa B subunit 1 Homo sapiens 73-82 23424864-0 2012 [Experimental study on delta-tocotrienol inhibits the Wnt pathway in the colon cancer cell SW620]. tocotrienol, delta 23-40 Wnt family member 1 Homo sapiens 54-57 23424864-1 2012 OBJECTIVE: Based on the antitumor function of the delta-tocotrienol, shed light on the relationship between the proliferation inhibition effect of delta-tocotrienol on human colon cancer cells SW620 with Wnt signal pathway. tocotrienol, delta 50-67 Wnt family member 1 Homo sapiens 204-207 23424864-1 2012 OBJECTIVE: Based on the antitumor function of the delta-tocotrienol, shed light on the relationship between the proliferation inhibition effect of delta-tocotrienol on human colon cancer cells SW620 with Wnt signal pathway. tocotrienol, delta 147-164 Wnt family member 1 Homo sapiens 204-207 23424864-3 2012 Detected the expressions level of the factors related to Wnt signal pathway via Western bloting and immunocytochemistry, to observe the influence of delta-tocotrienol on Wnt-1, beta-catenin, c-jun, cylin D1. tocotrienol, delta 149-166 Wnt family member 1 Homo sapiens 170-175 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 51-68 Wnt family member 1 Homo sapiens 183-188 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 51-68 catenin beta 1 Homo sapiens 190-202 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 51-68 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 204-209 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 51-68 Wnt family member 1 Homo sapiens 227-230 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 124-141 Wnt family member 1 Homo sapiens 183-188 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 124-141 catenin beta 1 Homo sapiens 190-202 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 124-141 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 204-209 23424864-7 2012 CONCLUSION: The proliferation inhibition effect of delta-tocotrienol on colon cancer cell may correlate with the ability of delta-tocotrienol to downregulate the expression levels of wnt-1, beta-catenin, c-jun, cylin D1 in the Wnt signal pathway. tocotrienol, delta 124-141 Wnt family member 1 Homo sapiens 227-230 22927884-3 2012 Delta-tocotrienol had been found to stimulate the cleavage of HMGCoA reductase and inhibit its activity. tocotrienol, delta 0-17 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 62-78 21526401-4 2012 The production of IL-8 and IL-6 was lowest in delta-tocotrienol (delta-T3)-treated cells followed by gamma-tocotrienol (gamma-T3) and TRF. tocotrienol, delta 46-63 chemokine (C-X-C motif) ligand 15 Mus musculus 18-22 21526401-4 2012 The production of IL-8 and IL-6 was lowest in delta-tocotrienol (delta-T3)-treated cells followed by gamma-tocotrienol (gamma-T3) and TRF. tocotrienol, delta 46-63 interleukin 6 Mus musculus 27-31 22185406-8 2011 There was a 2-fold increase in the production of NO, when LPS-stimulated macrophages of quercetin, delta-tocotrienol, or dexamethasone were also treated with IFN-beta or IFN-gamma compared to respective control groups. tocotrienol, delta 99-116 interferon beta 1, fibroblast Mus musculus 158-166 22185406-8 2011 There was a 2-fold increase in the production of NO, when LPS-stimulated macrophages of quercetin, delta-tocotrienol, or dexamethasone were also treated with IFN-beta or IFN-gamma compared to respective control groups. tocotrienol, delta 99-116 interferon gamma Mus musculus 170-179 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 interleukin 1 beta Mus musculus 189-197 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 interleukin 1 alpha Mus musculus 199-208 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 interleukin 6 Mus musculus 210-214 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 tumor necrosis factor Mus musculus 216-225 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 nitric oxide synthase 2, inducible Mus musculus 234-238 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 vascular cell adhesion molecule 1 Mus musculus 240-245 22185406-2 2011 We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, delta-tocotrienol, and riboflavin) can inhibit lipopolysaccharide (LPS)-induced NO production in vitro by RAW 264.7 cells and by thioglycolate-elicited peritoneal macrophages derived from four strains of mice (C57BL/6, BALB/c, LMP7/MECL-1(-/-) and PPAR-alpha(-/-) knockout mice). tocotrienol, delta 91-108 proteasome (prosome, macropain) subunit, beta type 10 Mus musculus 323-329 22185406-2 2011 We have recently reported that proteasome inhibitors (dexamethasone, mevinolin, quercetin, delta-tocotrienol, and riboflavin) can inhibit lipopolysaccharide (LPS)-induced NO production in vitro by RAW 264.7 cells and by thioglycolate-elicited peritoneal macrophages derived from four strains of mice (C57BL/6, BALB/c, LMP7/MECL-1(-/-) and PPAR-alpha(-/-) knockout mice). tocotrienol, delta 91-108 peroxisome proliferator activated receptor alpha Mus musculus 339-349 21356098-8 2011 The serum levels of TNF-alpha and NO were decreased 61% - 84% (P < 0.001), and 14% - 67%, respectively, in chickens fed diets supplemented with delta-tocotrienol, quercetin, riboflavin, (-) Corey lactone, amiloride, or dexamethasone as compared to controls. tocotrienol, delta 147-164 lipopolysaccharide induced TNF factor Gallus gallus 20-29 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 intercellular adhesion molecule 1 Mus musculus 247-252 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 cytochrome c oxidase II, mitochondrial Mus musculus 254-258 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 interleukin 1 receptor antagonist Mus musculus 260-266 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 TNF receptor-associated factor 1 Mus musculus 268-273 22185406-13 2011 The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). tocotrienol, delta 86-103 CD40 antigen Mus musculus 278-282 21971120-0 2011 Vitamin E delta-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-kappaB activation in pancreatic cancer. tocotrienol, delta 10-27 nuclear factor kappa B subunit 1 Homo sapiens 103-112 21971120-6 2011 Moreover, we found that delta-tocotrienol augmentation of gemcitabine activity in pancreatic cancer cells and tumors is associated with significant suppression of NF-kappaB activity and the expression of NF-kappaB transcriptional targets (Bcl-X(L), X-linked inhibitor of apoptosis, and survivin). tocotrienol, delta 24-41 nuclear factor kappa B subunit 1 Homo sapiens 163-172 21971120-6 2011 Moreover, we found that delta-tocotrienol augmentation of gemcitabine activity in pancreatic cancer cells and tumors is associated with significant suppression of NF-kappaB activity and the expression of NF-kappaB transcriptional targets (Bcl-X(L), X-linked inhibitor of apoptosis, and survivin). tocotrienol, delta 24-41 nuclear factor kappa B subunit 1 Homo sapiens 204-213 21971120-6 2011 Moreover, we found that delta-tocotrienol augmentation of gemcitabine activity in pancreatic cancer cells and tumors is associated with significant suppression of NF-kappaB activity and the expression of NF-kappaB transcriptional targets (Bcl-X(L), X-linked inhibitor of apoptosis, and survivin). tocotrienol, delta 24-41 BCL2 like 1 Homo sapiens 239-247 21971120-6 2011 Moreover, we found that delta-tocotrienol augmentation of gemcitabine activity in pancreatic cancer cells and tumors is associated with significant suppression of NF-kappaB activity and the expression of NF-kappaB transcriptional targets (Bcl-X(L), X-linked inhibitor of apoptosis, and survivin). tocotrienol, delta 24-41 X-linked inhibitor of apoptosis Homo sapiens 249-280 21971120-8 2011 Given these results, we are conducting a phase I trial of delta-tocotrienol in patients with pancreatic cancer using pancreatic tumor cell survival and NF-kappaB signaling components as intermediate biomarkers. tocotrienol, delta 58-75 nuclear factor kappa B subunit 1 Homo sapiens 152-161 21453743-0 2011 A paraptosis-like cell death induced by delta-tocotrienol in human colon carcinoma SW620 cells is associated with the suppression of the Wnt signaling pathway. tocotrienol, delta 40-57 Wnt family member 1 Homo sapiens 137-140 21453743-4 2011 Our findings showed that delta-tocotrienol effectively induced paraptosis-like death in SW620 cells, correlated with the vacuolation that may be from welling and fusion of mitochondria and/or the endoplasmic reticulum (ER) as well as caspase-3 nonactivated. tocotrienol, delta 25-42 caspase 3 Homo sapiens 234-243 21453743-6 2011 Of being noted, delta-tocotrienol reduced the expression of beta-catenin and wnt-1 proteins by about 50% at the highest dose (20mumol/L). tocotrienol, delta 16-33 catenin beta 1 Homo sapiens 60-72 21453743-6 2011 Of being noted, delta-tocotrienol reduced the expression of beta-catenin and wnt-1 proteins by about 50% at the highest dose (20mumol/L). tocotrienol, delta 16-33 Wnt family member 1 Homo sapiens 77-82 21453743-7 2011 delta-Tocotrienol also decreased cyclin D1, c-jun and MMP-7 protein levels in SW620 cells. tocotrienol, delta 0-17 cyclin D1 Homo sapiens 33-42 21453743-7 2011 delta-Tocotrienol also decreased cyclin D1, c-jun and MMP-7 protein levels in SW620 cells. tocotrienol, delta 0-17 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 44-49 21453743-7 2011 delta-Tocotrienol also decreased cyclin D1, c-jun and MMP-7 protein levels in SW620 cells. tocotrienol, delta 0-17 matrix metallopeptidase 7 Homo sapiens 54-59 21453743-8 2011 Altogether, these data indicate that delta-tocotrienol induces paraptosis-like cell death, which is associated with the suppression of the Wnt signaling pathway. tocotrienol, delta 37-54 Wnt family member 1 Homo sapiens 139-142 21992595-15 2011 CONCLUSIONS: Results of the current study demonstrate that delta-tocotrienol, riboflavin, and quercetin inhibit NO production by LPS-stimulated macrophages of all four strains of mice, and TNF-alpha, secretion only by LPS-stimulated macrophages of C57BL/6 and BALB/c mice. tocotrienol, delta 59-76 tumor necrosis factor Mus musculus 189-198 21598300-0 2011 Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. tocotrienol, delta 92-109 notch receptor 1 Homo sapiens 129-136 21598300-5 2011 The objective of this study was to investigate whether delta-tocotrienol, a naturally occurring isoform of Vitamin E, inhibits non-small cell lung cancer cell growth via Notch signaling. tocotrienol, delta 55-72 notch receptor 1 Homo sapiens 170-175 21598300-7 2011 Real-time RT-PCR and western blot analysis showed that antitumor activity by delta-tocotrienol was associated with a decrease in Notch-1, Hes-1, Survivin, MMP-9, VEGF, and Bcl-XL expression. tocotrienol, delta 77-94 notch receptor 1 Homo sapiens 129-136 21598300-7 2011 Real-time RT-PCR and western blot analysis showed that antitumor activity by delta-tocotrienol was associated with a decrease in Notch-1, Hes-1, Survivin, MMP-9, VEGF, and Bcl-XL expression. tocotrienol, delta 77-94 hes family bHLH transcription factor 1 Homo sapiens 138-143 21598300-7 2011 Real-time RT-PCR and western blot analysis showed that antitumor activity by delta-tocotrienol was associated with a decrease in Notch-1, Hes-1, Survivin, MMP-9, VEGF, and Bcl-XL expression. tocotrienol, delta 77-94 matrix metallopeptidase 9 Homo sapiens 155-160 21598300-7 2011 Real-time RT-PCR and western blot analysis showed that antitumor activity by delta-tocotrienol was associated with a decrease in Notch-1, Hes-1, Survivin, MMP-9, VEGF, and Bcl-XL expression. tocotrienol, delta 77-94 vascular endothelial growth factor A Homo sapiens 162-166 21598300-7 2011 Real-time RT-PCR and western blot analysis showed that antitumor activity by delta-tocotrienol was associated with a decrease in Notch-1, Hes-1, Survivin, MMP-9, VEGF, and Bcl-XL expression. tocotrienol, delta 77-94 BCL2 like 1 Homo sapiens 172-178 21598300-9 2011 These results suggest that down-regulation of Notch-1, via inhibition of NF-kappaB signaling pathways by delta-tocotrienol, could provide a potential novel approach for prevention of tumor progression in non-small cell lung cancer. tocotrienol, delta 105-122 notch receptor 1 Homo sapiens 46-53 21598300-9 2011 These results suggest that down-regulation of Notch-1, via inhibition of NF-kappaB signaling pathways by delta-tocotrienol, could provide a potential novel approach for prevention of tumor progression in non-small cell lung cancer. tocotrienol, delta 105-122 nuclear factor kappa B subunit 1 Homo sapiens 73-82 21356098-4 2011 We evaluated these compounds in an avian model anticipating that a dietary additive combining delta-tocotrienol with quercetin, riboflavin, (-) Corey lactone, amiloride, or dexamethasone would yield greater reductions in serum levels of total cholesterol, LDL-cholesterol and inflammatory markers (tumor necrosis factor-alpha [TNF-alpha], and nitric oxide [NO]), than that attained with the individual compounds. tocotrienol, delta 94-111 lipopolysaccharide induced TNF factor Gallus gallus 298-325 21356098-4 2011 We evaluated these compounds in an avian model anticipating that a dietary additive combining delta-tocotrienol with quercetin, riboflavin, (-) Corey lactone, amiloride, or dexamethasone would yield greater reductions in serum levels of total cholesterol, LDL-cholesterol and inflammatory markers (tumor necrosis factor-alpha [TNF-alpha], and nitric oxide [NO]), than that attained with the individual compounds. tocotrienol, delta 94-111 lipopolysaccharide induced TNF factor Gallus gallus 327-336 21162750-9 2010 Maximal inhibition of LPS-induced TNF-alpha was obtained with delta-tocotrienol (10 mug/kg). tocotrienol, delta 62-79 tumor necrosis factor Mus musculus 34-43 21162750-10 2010 Low concentrations of delta-Tocotrienols (< 20 muM) blocked LPS-induced gene expression of TNF-alpha, IL-1beta, IL-6 and iNOS (> 40%), while higher concentrations (40 muM) increased gene expression of the latter in peritoneal macrophages (prepared from BALB/c mice) as compared to control group. tocotrienol, delta 22-40 nitric oxide synthase 2, inducible Mus musculus 124-128 21162750-10 2010 Low concentrations of delta-Tocotrienols (< 20 muM) blocked LPS-induced gene expression of TNF-alpha, IL-1beta, IL-6 and iNOS (> 40%), while higher concentrations (40 muM) increased gene expression of the latter in peritoneal macrophages (prepared from BALB/c mice) as compared to control group. tocotrienol, delta 22-40 tumor necrosis factor Mus musculus 94-103 21162750-10 2010 Low concentrations of delta-Tocotrienols (< 20 muM) blocked LPS-induced gene expression of TNF-alpha, IL-1beta, IL-6 and iNOS (> 40%), while higher concentrations (40 muM) increased gene expression of the latter in peritoneal macrophages (prepared from BALB/c mice) as compared to control group. tocotrienol, delta 22-40 interleukin 1 beta Mus musculus 105-113 21162750-10 2010 Low concentrations of delta-Tocotrienols (< 20 muM) blocked LPS-induced gene expression of TNF-alpha, IL-1beta, IL-6 and iNOS (> 40%), while higher concentrations (40 muM) increased gene expression of the latter in peritoneal macrophages (prepared from BALB/c mice) as compared to control group. tocotrienol, delta 22-40 interleukin 6 Mus musculus 115-119 20823559-5 2010 Tyrosinase activity, amounts of tyrosinase and TRP-1 decreased dependent on dose : by 50 (25 microM delta-tocotrienol) to 75% (50 microM), 20 to 45% and 42 to 82% at 48 h, and by 25 to 50%, 75 to 80% and 78 to 77% at 72 h, respectively. tocotrienol, delta 100-117 tyrosinase Mus musculus 0-10 20823133-5 2010 DESIGN AND METHODS: CD2F1 mice and human hematopoietic progenitor CD34(+) cells were treated with delta-tocotrienol or vehicle control 24 h before or 6 h after gamma-irradiation. tocotrienol, delta 98-115 CD34 molecule Homo sapiens 66-70 20823133-10 2010 delta-tocotrienol increased cell survival, and regeneration of hematopoietic microfoci and lineage(-)/Sca-1(+)/ckit(+) stem and progenitor cells in irradiated mouse bone marrow, and protected human CD34(+) cells from radiation-induced damage. tocotrienol, delta 0-17 lymphocyte antigen 6 complex, locus A Mus musculus 102-107 20823133-10 2010 delta-tocotrienol increased cell survival, and regeneration of hematopoietic microfoci and lineage(-)/Sca-1(+)/ckit(+) stem and progenitor cells in irradiated mouse bone marrow, and protected human CD34(+) cells from radiation-induced damage. tocotrienol, delta 0-17 CD34 molecule Homo sapiens 198-202 20823133-11 2010 delta-tocotrienol activated extracellular signal-related kinase 1/2 phosphorylation and significantly inhibited formation of DNA-damage marker gamma-H2AX foci. tocotrienol, delta 0-17 mitogen-activated protein kinase 3 Homo sapiens 28-65 20823133-12 2010 In addition, delta-tocotrienol up-regulated mammalian target of rapamycin and phosphorylation of its downstream effector 4EBP-1. tocotrienol, delta 13-30 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 121-127 20823133-14 2010 Inhibition of extracellular signal-related kinase 1/2 expression by short interfering RNA abrogated delta-tocotrienol-induced mammalian target of rapamycin phosphorylation and clonogenicity, and increased gamma-H2AX foci formation in irradiated CD34(+) cells. tocotrienol, delta 100-117 mitogen-activated protein kinase 3 Homo sapiens 14-53 20823133-14 2010 Inhibition of extracellular signal-related kinase 1/2 expression by short interfering RNA abrogated delta-tocotrienol-induced mammalian target of rapamycin phosphorylation and clonogenicity, and increased gamma-H2AX foci formation in irradiated CD34(+) cells. tocotrienol, delta 100-117 CD34 molecule Homo sapiens 245-249 20823133-15 2010 CONCLUSIONS: Our data indicate that delta-tocotrienol protects mouse bone marrow and human CD34(+) cells from radiation-induced damage through extracellular signal-related kinase activation-associated mammalian target of rapamycin survival pathways. tocotrienol, delta 36-53 CD34 molecule Homo sapiens 91-95 19866471-7 2010 Specifically, both alpha- and gamma-tocotrienol activated PPARalpha, while delta-tocotrienol activated PPARalpha, PPARgamma, and PPARdelta in reporter-based assays. tocotrienol, delta 75-92 peroxisome proliferator activated receptor alpha Homo sapiens 103-112 19866471-7 2010 Specifically, both alpha- and gamma-tocotrienol activated PPARalpha, while delta-tocotrienol activated PPARalpha, PPARgamma, and PPARdelta in reporter-based assays. tocotrienol, delta 75-92 peroxisome proliferator activated receptor gamma Homo sapiens 114-123 19866471-7 2010 Specifically, both alpha- and gamma-tocotrienol activated PPARalpha, while delta-tocotrienol activated PPARalpha, PPARgamma, and PPARdelta in reporter-based assays. tocotrienol, delta 75-92 peroxisome proliferator activated receptor delta Homo sapiens 129-138 20823559-6 2010 Although the amount of TRP-2 increased by 20% on treatment with 25 microM delta-tocotrienol for 48 h, it decreased by 52% on treatment with 50 microM delta-tocotrienol for 48 h. The amount of TRP-2 dose-dependently decreased by 55% and 75% on 72 h by treatment with 25 and 50 microM delta-tocotrienol, respectively. tocotrienol, delta 74-91 tRNA proline 2 Mus musculus 23-28 20823559-6 2010 Although the amount of TRP-2 increased by 20% on treatment with 25 microM delta-tocotrienol for 48 h, it decreased by 52% on treatment with 50 microM delta-tocotrienol for 48 h. The amount of TRP-2 dose-dependently decreased by 55% and 75% on 72 h by treatment with 25 and 50 microM delta-tocotrienol, respectively. tocotrienol, delta 74-91 tRNA proline 2 Mus musculus 192-197 20823559-6 2010 Although the amount of TRP-2 increased by 20% on treatment with 25 microM delta-tocotrienol for 48 h, it decreased by 52% on treatment with 50 microM delta-tocotrienol for 48 h. The amount of TRP-2 dose-dependently decreased by 55% and 75% on 72 h by treatment with 25 and 50 microM delta-tocotrienol, respectively. tocotrienol, delta 150-167 tRNA proline 2 Mus musculus 192-197 20823559-6 2010 Although the amount of TRP-2 increased by 20% on treatment with 25 microM delta-tocotrienol for 48 h, it decreased by 52% on treatment with 50 microM delta-tocotrienol for 48 h. The amount of TRP-2 dose-dependently decreased by 55% and 75% on 72 h by treatment with 25 and 50 microM delta-tocotrienol, respectively. tocotrienol, delta 150-167 tRNA proline 2 Mus musculus 192-197 20823559-7 2010 From these findings, delta-tocotrienol at up to 50 microM dose-dependently caused a reduction in melanin content by the decrease of TRP-1 and TRP-2 as well as tyrosinase, and no cytotoxicity. tocotrienol, delta 21-38 tyrosinase-related protein 1 Mus musculus 132-137 20823559-7 2010 From these findings, delta-tocotrienol at up to 50 microM dose-dependently caused a reduction in melanin content by the decrease of TRP-1 and TRP-2 as well as tyrosinase, and no cytotoxicity. tocotrienol, delta 21-38 tRNA proline 2 Mus musculus 142-147 20823559-7 2010 From these findings, delta-tocotrienol at up to 50 microM dose-dependently caused a reduction in melanin content by the decrease of TRP-1 and TRP-2 as well as tyrosinase, and no cytotoxicity. tocotrienol, delta 21-38 tyrosinase Mus musculus 159-169 19702331-0 2009 delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not. tocotrienol, delta 0-17 vascular endothelial growth factor A Homo sapiens 29-33 12656204-0 2002 Inhibitory effect of delta-tocotrienol, a HMG CoA reductase inhibitor, on monocyte-endothelial cell adhesion. tocotrienol, delta 21-38 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 42-59 18810749-10 2008 Additional expression of the tocopherol cyclase gene vte1 from Arabidopsis thaliana resulted in the novel formation of a vitamin E compound-delta-tocotrienol (15 microg g(-1))-in E. coli. tocotrienol, delta 140-157 tocopherol cyclase, chloroplast / vitamin E deficient 1 (VTE1) / sucrose export defective 1 (SXD1) Arabidopsis thaliana 53-57 19035289-0 2008 Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product. tocotrienol, delta 61-78 cyclin D1 Homo sapiens 106-115 19035289-0 2008 Growth inhibition of human MDA-mB-231 breast cancer cells by delta-tocotrienol is associated with loss of cyclin D1/CDK4 expression and accompanying changes in the state of phosphorylation of the retinoblastoma tumor suppressor gene product. tocotrienol, delta 61-78 cyclin dependent kinase 4 Homo sapiens 116-120 19035289-5 2008 The site-specific inhibition of the phosphorylation of Rb by delta-tocotrienol was tightly associated with a marked reduction in the expression of cyclin D1 and its regulatory partner cyclin-dependant kinase 4 (CDK4), which is responsible for the phosphorylation of Rb at Ser780, Ser795, Ser 807/811 and Thr826. tocotrienol, delta 61-78 cyclin D1 Homo sapiens 147-156 19035289-5 2008 The site-specific inhibition of the phosphorylation of Rb by delta-tocotrienol was tightly associated with a marked reduction in the expression of cyclin D1 and its regulatory partner cyclin-dependant kinase 4 (CDK4), which is responsible for the phosphorylation of Rb at Ser780, Ser795, Ser 807/811 and Thr826. tocotrienol, delta 61-78 cyclin dependent kinase 4 Homo sapiens 184-209 19035289-5 2008 The site-specific inhibition of the phosphorylation of Rb by delta-tocotrienol was tightly associated with a marked reduction in the expression of cyclin D1 and its regulatory partner cyclin-dependant kinase 4 (CDK4), which is responsible for the phosphorylation of Rb at Ser780, Ser795, Ser 807/811 and Thr826. tocotrienol, delta 61-78 cyclin dependent kinase 4 Homo sapiens 211-215 19035289-7 2008 Interestingly, delta-tocotrienol also caused a marked reduction in the expression of G2/M regulatory proteins including cyclin B1 and CDK1. tocotrienol, delta 15-32 cyclin dependent kinase 1 Homo sapiens 134-138 19035289-8 2008 To the best of our knowledge, this study was the first to reveal that the target of cell proliferative inhibitory action of delta-tocotrienol in a model estrogen receptor-negative human breast cancer cell line MDA-MB-231 is mediated by the loss of cyclin D1 and associated suppression of site-specific Rb phosphorylation, suggesting its future development and use as an anticancer agent. tocotrienol, delta 124-141 cyclin D1 Homo sapiens 248-257 16098658-6 2005 On the other hand, gene expression analysis showed that delta-tocotrienol increased CYP1A1 gene, a phase I enzyme. tocotrienol, delta 56-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 15203383-5 2004 The pro-apoptotic mechanisms triggered by the structurally distinct alpha-TEA and delta-tocotrienol were identical to those previously reported for VES, that is, alpha-TEA- and delta-tocotrienol-induced apoptosis involved up-regulation of TGF-beta receptor II expression and TGF-beta-, Fas- and JNK-signaling pathways. tocotrienol, delta 177-194 mitogen-activated protein kinase 8 Homo sapiens 295-298 12913317-3 2003 Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. tocotrienol, delta 6-23 vascular endothelial growth factor A Homo sapiens 36-70