PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25325362-4	2015	In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN.	nobiletin	36-45	glial cell derived neurotrophic factor	Rattus norvegicus	136-179
26012256-0	2015	Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung cancer cells by inactivating of Notch-1 signaling and switching on miR-200b.	nobiletin	0-9	notch receptor 1	Homo sapiens	110-117
26012256-0	2015	Nobiletin inhibited hypoxia-induced epithelial-mesenchymal transition of lung cancer cells by inactivating of Notch-1 signaling and switching on miR-200b.	nobiletin	0-9	microRNA 200b	Homo sapiens	145-153
26012256-5	2015	According to previous screening, nobiletin was selected as a Notch-1 inhibitor.	nobiletin	33-42	notch receptor 1	Homo sapiens	61-68
26012256-7	2015	Treatment with nobiletin notably attenuated hypoxia-induced EMT, invasion and migration in H1299 cells, accompanied with reduced Notch-1, Jagged1/2 expressions and its downstream genes Hey-1 and Hes-1.	nobiletin	15-24	notch receptor 1	Homo sapiens	129-136
26012256-7	2015	Treatment with nobiletin notably attenuated hypoxia-induced EMT, invasion and migration in H1299 cells, accompanied with reduced Notch-1, Jagged1/2 expressions and its downstream genes Hey-1 and Hes-1.	nobiletin	15-24	jagged canonical Notch ligand 1	Homo sapiens	138-145
26012256-7	2015	Treatment with nobiletin notably attenuated hypoxia-induced EMT, invasion and migration in H1299 cells, accompanied with reduced Notch-1, Jagged1/2 expressions and its downstream genes Hey-1 and Hes-1.	nobiletin	15-24	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	185-190
26012256-7	2015	Treatment with nobiletin notably attenuated hypoxia-induced EMT, invasion and migration in H1299 cells, accompanied with reduced Notch-1, Jagged1/2 expressions and its downstream genes Hey-1 and Hes-1.	nobiletin	15-24	hes family bHLH transcription factor 1	Homo sapiens	195-200
25563790-0	2015	Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2.	nobiletin	0-9	mitogen-activated protein kinase 3	Homo sapiens	100-106
25563790-0	2015	Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2.	nobiletin	0-9	matrix metallopeptidase 2	Homo sapiens	141-146
25563790-7	2015	Nobiletin also showed that inhibits phosphorylation of ERK1/2.	nobiletin	0-9	mitogen-activated protein kinase 3	Homo sapiens	55-61
25563790-9	2015	Nobiletin inhibits MMP-2 expression, up-regulating tissue inhibitor of metalloproteinase-2 and down-regulation of the transcription factors of NF-kappaB and activator protein 1 (AP-1) signaling pathways.	nobiletin	0-9	matrix metallopeptidase 2	Homo sapiens	19-24
25563790-9	2015	Nobiletin inhibits MMP-2 expression, up-regulating tissue inhibitor of metalloproteinase-2 and down-regulation of the transcription factors of NF-kappaB and activator protein 1 (AP-1) signaling pathways.	nobiletin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-176
25563790-9	2015	Nobiletin inhibits MMP-2 expression, up-regulating tissue inhibitor of metalloproteinase-2 and down-regulation of the transcription factors of NF-kappaB and activator protein 1 (AP-1) signaling pathways.	nobiletin	0-9	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	178-182
25845666-0	2015	The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway.	nobiletin	14-23	AKT serine/threonine kinase 1	Homo sapiens	90-93
25488359-0	2015	Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes.	nobiletin	0-9	endothelin 1	Homo sapiens	44-56
25488359-0	2015	Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes.	nobiletin	0-9	KIT ligand	Homo sapiens	62-65
25488359-3	2015	Nobiletin dose dependently reduced ET plus SCF-stimulated tyrosinase activity without causing cytotoxicity.	nobiletin	0-9	KIT ligand	Homo sapiens	43-46
25488359-3	2015	Nobiletin dose dependently reduced ET plus SCF-stimulated tyrosinase activity without causing cytotoxicity.	nobiletin	0-9	tyrosinase	Homo sapiens	58-68
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	cAMP responsive element binding protein 1	Homo sapiens	18-55
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	cAMP responsive element binding protein 1	Homo sapiens	57-61
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	melanocyte inducing transcription factor	Homo sapiens	83-129
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	melanocyte inducing transcription factor	Homo sapiens	131-135
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	tyrosinase	Homo sapiens	189-199
25488359-4	2015	Nobiletin reduced cAMP-response element-binding protein (CREB) phosphorylation and microphthalmia-associated transcription factor (MITF) expression, which is a key transcription factor for tyrosinase expression in pigmentation induced by ET plus SCF stimulation.	nobiletin	0-9	KIT ligand	Homo sapiens	246-249
25488359-5	2015	Nobiletin treatment effectively decreased ET plus SCF-induced Raf-1, MEK and ERK1/2 phosphorylation and also downregulated the forskolin-induced phosphorylation of CREB.	nobiletin	0-9	KIT ligand	Homo sapiens	50-53
25488359-5	2015	Nobiletin treatment effectively decreased ET plus SCF-induced Raf-1, MEK and ERK1/2 phosphorylation and also downregulated the forskolin-induced phosphorylation of CREB.	nobiletin	0-9	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	62-67
25488359-5	2015	Nobiletin treatment effectively decreased ET plus SCF-induced Raf-1, MEK and ERK1/2 phosphorylation and also downregulated the forskolin-induced phosphorylation of CREB.	nobiletin	0-9	mitogen-activated protein kinase kinase 7	Homo sapiens	69-72
25488359-5	2015	Nobiletin treatment effectively decreased ET plus SCF-induced Raf-1, MEK and ERK1/2 phosphorylation and also downregulated the forskolin-induced phosphorylation of CREB.	nobiletin	0-9	mitogen-activated protein kinase 3	Homo sapiens	77-83
25488359-5	2015	Nobiletin treatment effectively decreased ET plus SCF-induced Raf-1, MEK and ERK1/2 phosphorylation and also downregulated the forskolin-induced phosphorylation of CREB.	nobiletin	0-9	cAMP responsive element binding protein 1	Homo sapiens	164-168
25488359-6	2015	Furthermore, nobiletin inhibited ET plus SCF-triggered production of melanin and expression of MITF/tyrosinase in a three-dimensional human epidermal model.	nobiletin	13-22	KIT ligand	Homo sapiens	41-44
25488359-6	2015	Furthermore, nobiletin inhibited ET plus SCF-triggered production of melanin and expression of MITF/tyrosinase in a three-dimensional human epidermal model.	nobiletin	13-22	melanocyte inducing transcription factor	Homo sapiens	95-99
25488359-6	2015	Furthermore, nobiletin inhibited ET plus SCF-triggered production of melanin and expression of MITF/tyrosinase in a three-dimensional human epidermal model.	nobiletin	13-22	tyrosinase	Homo sapiens	100-110
25488359-8	2015	Nobiletin contributes to hypopigmentation by downregulating MITF and tyrosinase expression through reduced Raf-1 phosphorylation.	nobiletin	0-9	melanocyte inducing transcription factor	Homo sapiens	60-64
25488359-8	2015	Nobiletin contributes to hypopigmentation by downregulating MITF and tyrosinase expression through reduced Raf-1 phosphorylation.	nobiletin	0-9	tyrosinase	Homo sapiens	69-79
25488359-8	2015	Nobiletin contributes to hypopigmentation by downregulating MITF and tyrosinase expression through reduced Raf-1 phosphorylation.	nobiletin	0-9	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	107-112
25511703-3	2015	Nobiletin markedly enhanced the expression of granzyme B, a serine protease that plays critical roles in the cytolytic activity of NK cells.	nobiletin	0-9	granzyme B	Homo sapiens	46-56
25511703-4	2015	The potentiated cytolytic activity induced by nobiletin was canceled by the granzyme B inhibitor Z-AAD-CMK.	nobiletin	46-55	granzyme B	Homo sapiens	76-86
25511703-4	2015	The potentiated cytolytic activity induced by nobiletin was canceled by the granzyme B inhibitor Z-AAD-CMK.	nobiletin	46-55	C-X-C motif chemokine ligand 9	Homo sapiens	103-106
25511703-5	2015	Nobiletin also increased the levels of phosphorylated CREB, ERK1/2, and p38 MAPK in KHYG-1 cells, which are known to participate in NK cell function.	nobiletin	0-9	cAMP responsive element binding protein 1	Homo sapiens	54-58
25511703-5	2015	Nobiletin also increased the levels of phosphorylated CREB, ERK1/2, and p38 MAPK in KHYG-1 cells, which are known to participate in NK cell function.	nobiletin	0-9	mitogen-activated protein kinase 3	Homo sapiens	60-66
25511703-5	2015	Nobiletin also increased the levels of phosphorylated CREB, ERK1/2, and p38 MAPK in KHYG-1 cells, which are known to participate in NK cell function.	nobiletin	0-9	mitogen-activated protein kinase 1	Homo sapiens	72-75
25511703-8	2015	These results suggest that the primary role of nobiletin in KHYG-1 cytolytic activity lies in upregulation of granzyme B expression, at least in part, mediated through p38 MAPK function.	nobiletin	47-56	granzyme B	Homo sapiens	110-120
25511703-8	2015	These results suggest that the primary role of nobiletin in KHYG-1 cytolytic activity lies in upregulation of granzyme B expression, at least in part, mediated through p38 MAPK function.	nobiletin	47-56	mitogen-activated protein kinase 1	Homo sapiens	168-171
25511703-8	2015	These results suggest that the primary role of nobiletin in KHYG-1 cytolytic activity lies in upregulation of granzyme B expression, at least in part, mediated through p38 MAPK function.	nobiletin	47-56	mitogen-activated protein kinase 3	Homo sapiens	172-176
25845666-11	2015	We observed that nobiletin inhibits secretion of the key angiogenesis mediators, Akt, HIF-1alpha, NF-kappaB and vascular epithelial growth factor (VEGF) by ovarian cancer cells.	nobiletin	17-26	AKT serine/threonine kinase 1	Homo sapiens	81-84
25845666-11	2015	We observed that nobiletin inhibits secretion of the key angiogenesis mediators, Akt, HIF-1alpha, NF-kappaB and vascular epithelial growth factor (VEGF) by ovarian cancer cells.	nobiletin	17-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
25845666-11	2015	We observed that nobiletin inhibits secretion of the key angiogenesis mediators, Akt, HIF-1alpha, NF-kappaB and vascular epithelial growth factor (VEGF) by ovarian cancer cells.	nobiletin	17-26	vascular endothelial growth factor A	Homo sapiens	112-145
25845666-11	2015	We observed that nobiletin inhibits secretion of the key angiogenesis mediators, Akt, HIF-1alpha, NF-kappaB and vascular epithelial growth factor (VEGF) by ovarian cancer cells.	nobiletin	17-26	vascular endothelial growth factor A	Homo sapiens	147-151
25845666-12	2015	Transient transfection experiments showed that nobiletin inhibits production of HIF-1alpha by downregulation of Akt.	nobiletin	47-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90
25845666-12	2015	Transient transfection experiments showed that nobiletin inhibits production of HIF-1alpha by downregulation of Akt.	nobiletin	47-56	AKT serine/threonine kinase 1	Homo sapiens	112-115
25759053-5	2015	Also, we have demonstrated that nobiletin ameliorates cognitive impairment in several dementia model animals such as chronically amyloid beta(Abeta) infused rats, amyloid precursor protein transgenic (APPTg) mice, olfactory-bulbectomized (OBX) mice, N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801)-treated mice, senescence-accelated mice and bilaterial common carotid arteries occlusion mice.	nobiletin	32-41	amyloid beta precursor protein	Rattus norvegicus	163-188
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	nobiletin	19-28	cAMP responsive element binding protein 1	Mus musculus	101-138
25759053-9	2015	In cultured cells, nobiletin reversed the Abeta-induced inhibition of glutamate-induced increases in cAMP response element binding protein (CREB) phosphorylation and modulated gen expression of thioredoxin-interacting protein and NMDA resceptor subunits.	nobiletin	19-28	cAMP responsive element binding protein 1	Mus musculus	140-144
25452110-5	2014	Nobiletin inhibited PDGF-BB-induced VSMC proliferation and migration, attenuated reactive oxygen species (ROS) production and reduced phosphorylation of ERK1/2 and the expression of nuclear NF-kappaB p65 in PDGF-BB-stimulated VSMCs.	nobiletin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	153-159
25452110-5	2014	Nobiletin inhibited PDGF-BB-induced VSMC proliferation and migration, attenuated reactive oxygen species (ROS) production and reduced phosphorylation of ERK1/2 and the expression of nuclear NF-kappaB p65 in PDGF-BB-stimulated VSMCs.	nobiletin	0-9	synaptotagmin 1	Rattus norvegicus	200-203
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	mitogen-activated protein kinase 14	Homo sapiens	165-201
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	mitogen-activated protein kinase 1	Homo sapiens	203-207
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	BCL2 apoptosis regulator	Homo sapiens	264-269
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	271-274
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	BH3 interacting domain death agonist	Homo sapiens	279-282
25164609-0	2014	Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells.	nobiletin	0-9	caspase 8	Homo sapiens	81-90
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	tumor necrosis factor	Homo sapiens	132-141
25164609-5	2014	Moreover, nobiletin induced cell-cycle arrest of HL-60 AML cells at the G0/G1 phase by suppressing extracellular signal-regulated kinase (ERK) activity.	nobiletin	10-19	mitogen-activated protein kinase 1	Homo sapiens	99-136
25164609-5	2014	Moreover, nobiletin induced cell-cycle arrest of HL-60 AML cells at the G0/G1 phase by suppressing extracellular signal-regulated kinase (ERK) activity.	nobiletin	10-19	mitogen-activated protein kinase 1	Homo sapiens	138-141
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	caspase 8	Homo sapiens	76-85
25164609-6	2014	Furthermore, nobiletin effectively induced apoptosis of HL-60 cells through caspase-8, caspase-9, and caspases-3 activation concomitantly with a marked induction of p38 mitogen-activated protein kinase (MAPK) activation, but without affecting expression levels of Bcl-2, Bax, or Bid.	nobiletin	13-22	caspase 9	Homo sapiens	87-96
25342300-0	2014	Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	44-47
25342300-14	2014	Increasing HIF-1alpha levels reversed nobiletin"s inhibitory effects on VEGF expression, and up-regulating AKT levels reversed its inhibitory effects on HIF-1alpha expression.	nobiletin	38-47	vascular endothelial growth factor A	Homo sapiens	72-76
25342300-17	2014	CONCLUSION: Taken together, our results show that nobiletin suppresses cell viability through AKT pathways, with a more profound effect against the more metastatic PC-3 line.	nobiletin	50-59	AKT serine/threonine kinase 1	Homo sapiens	94-97
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	interleukin 1 beta	Homo sapiens	143-151
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	interleukin 6	Homo sapiens	153-157
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	C-X-C motif chemokine ligand 8	Homo sapiens	162-166
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	matrix metallopeptidase 9	Homo sapiens	172-177
25238390-8	2014	In human fetal membranes and myometrium, nobiletin significantly decreased LPS-stimulated expression of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6 and IL-8) and MMP-9 expression and pro-MMP-9 secretion.	nobiletin	41-50	matrix metallopeptidase 9	Homo sapiens	197-202
24692711-1	2014	UNLABELLED: Although nobiletin has a potent antitumor activity against several types of human cancers, its inhibitory effects and possible mechanisms of action on breast cancer cells with different hormone receptor and HER2 status remains unknown.	nobiletin	21-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	219-223
24784468-0	2014	Nobiletin, a flavone from Citrus depressa, induces gene expression and increases the protein level and activity of neprilysin in SK-N-SH cells.	nobiletin	0-9	membrane metalloendopeptidase	Homo sapiens	115-125
24784468-6	2014	Measurement of cellular NEP activity showed that nobiletin stimulated this in a dose- and time-dependent manner in SK-N-SH cells.	nobiletin	49-58	membrane metalloendopeptidase	Homo sapiens	24-27
24784468-8	2014	Our findings showed that nobiletin promoted NEP gene and protein expression, resulting in enhancement of cellular NEP activity in SK-N-SH cells.	nobiletin	25-34	membrane metalloendopeptidase	Homo sapiens	44-47
24784468-8	2014	Our findings showed that nobiletin promoted NEP gene and protein expression, resulting in enhancement of cellular NEP activity in SK-N-SH cells.	nobiletin	25-34	membrane metalloendopeptidase	Homo sapiens	114-117
24534366-2	2014	Recently, nobiletin was shown to provide therapeutic benefit for the treatment of Alzheimer s disease by activating cAMP-response element-binding protein (CREB).	nobiletin	10-19	cAMP responsive element binding protein 1	Rattus norvegicus	116-153
24534366-2	2014	Recently, nobiletin was shown to provide therapeutic benefit for the treatment of Alzheimer s disease by activating cAMP-response element-binding protein (CREB).	nobiletin	10-19	cAMP responsive element binding protein 1	Rattus norvegicus	155-159
24692711-4	2014	Nobiletin induced cell-cycle arrest at the G0/G1 phase by suppressing ERK1/2 activity, with concomitant cyclin-D1 suppression and p21 up-regulation.	nobiletin	0-9	mitogen-activated protein kinase 3	Homo sapiens	70-76
24692711-4	2014	Nobiletin induced cell-cycle arrest at the G0/G1 phase by suppressing ERK1/2 activity, with concomitant cyclin-D1 suppression and p21 up-regulation.	nobiletin	0-9	cyclin D1	Homo sapiens	104-113
24692711-4	2014	Nobiletin induced cell-cycle arrest at the G0/G1 phase by suppressing ERK1/2 activity, with concomitant cyclin-D1 suppression and p21 up-regulation.	nobiletin	0-9	H3 histone pseudogene 16	Homo sapiens	130-133
24692711-5	2014	Nobiletin induced apoptotic cell death by reducing Bcl-xL expression, without affecting Bax levels, and inhibited the activity of AKT and downstream mTOR in MDA-MB-468 cells, but not in other cell lines.	nobiletin	0-9	BCL2 like 1	Homo sapiens	51-57
24692711-5	2014	Nobiletin induced apoptotic cell death by reducing Bcl-xL expression, without affecting Bax levels, and inhibited the activity of AKT and downstream mTOR in MDA-MB-468 cells, but not in other cell lines.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	130-133
24692711-5	2014	Nobiletin induced apoptotic cell death by reducing Bcl-xL expression, without affecting Bax levels, and inhibited the activity of AKT and downstream mTOR in MDA-MB-468 cells, but not in other cell lines.	nobiletin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	149-153
24468189-7	2014	The effects of nobiletin on myosin light chain kinase (MLCK) mRNA expression, MLCK protein content, and myosin light chain phosphorylation extent were also bidirectional.	nobiletin	15-24	myosin light chain kinase	Rattus norvegicus	28-53
24468189-3	2014	Nobiletin-exerted BR on jejunal contractility was abolished in the presence of c-kit receptor tyrosine kinase inhibitor imatinib or Ca(2+) channel blocker verapamil.	nobiletin	0-9	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	79-109
23818450-8	2014	It was found that nobiletin downregulated the expressions of Bcl-2 and COX-2 and up-regulated the expressions of Bax and caspase-3 in SMMC-7721 cells by western blotting.	nobiletin	18-27	BCL2 apoptosis regulator	Homo sapiens	61-66
23818450-8	2014	It was found that nobiletin downregulated the expressions of Bcl-2 and COX-2 and up-regulated the expressions of Bax and caspase-3 in SMMC-7721 cells by western blotting.	nobiletin	18-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76
23818450-8	2014	It was found that nobiletin downregulated the expressions of Bcl-2 and COX-2 and up-regulated the expressions of Bax and caspase-3 in SMMC-7721 cells by western blotting.	nobiletin	18-27	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
23818450-8	2014	It was found that nobiletin downregulated the expressions of Bcl-2 and COX-2 and up-regulated the expressions of Bax and caspase-3 in SMMC-7721 cells by western blotting.	nobiletin	18-27	caspase 3	Homo sapiens	121-130
23818450-9	2014	The experiment in vivo demonstrated that nobiletin significantly inhibited the growth of H22 transplantable tumor, downregulated the expressions of COX-2, up-regulated the expressions of Bax and caspase-3 detected by immunohistochemistry and western blotting, and the ratios of Bcl-2/Bax were decreased.	nobiletin	41-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	148-153
23818450-9	2014	The experiment in vivo demonstrated that nobiletin significantly inhibited the growth of H22 transplantable tumor, downregulated the expressions of COX-2, up-regulated the expressions of Bax and caspase-3 detected by immunohistochemistry and western blotting, and the ratios of Bcl-2/Bax were decreased.	nobiletin	41-50	BCL2 associated X, apoptosis regulator	Homo sapiens	187-190
23818450-9	2014	The experiment in vivo demonstrated that nobiletin significantly inhibited the growth of H22 transplantable tumor, downregulated the expressions of COX-2, up-regulated the expressions of Bax and caspase-3 detected by immunohistochemistry and western blotting, and the ratios of Bcl-2/Bax were decreased.	nobiletin	41-50	caspase 3	Homo sapiens	195-204
23818450-9	2014	The experiment in vivo demonstrated that nobiletin significantly inhibited the growth of H22 transplantable tumor, downregulated the expressions of COX-2, up-regulated the expressions of Bax and caspase-3 detected by immunohistochemistry and western blotting, and the ratios of Bcl-2/Bax were decreased.	nobiletin	41-50	BCL2 apoptosis regulator	Homo sapiens	278-283
23818450-9	2014	The experiment in vivo demonstrated that nobiletin significantly inhibited the growth of H22 transplantable tumor, downregulated the expressions of COX-2, up-regulated the expressions of Bax and caspase-3 detected by immunohistochemistry and western blotting, and the ratios of Bcl-2/Bax were decreased.	nobiletin	41-50	BCL2 associated X, apoptosis regulator	Homo sapiens	284-287
24468189-7	2014	The effects of nobiletin on myosin light chain kinase (MLCK) mRNA expression, MLCK protein content, and myosin light chain phosphorylation extent were also bidirectional.	nobiletin	15-24	myosin light chain kinase	Rattus norvegicus	55-59
24964900-3	2014	For the first time, we have shown that nobiletin significantly upregulated mRNA expression of the NMDA receptor subunits NR1, NR2A, and NR2B in PC12D cells.	nobiletin	39-48	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	121-124
24389490-0	2014	Nobiletin suppresses MMP-9 expression through modulation of p38 MAPK activity in human dermal fibrobalsts.	nobiletin	0-9	matrix metallopeptidase 9	Homo sapiens	21-26
24389490-6	2014	Sustained p38 mitogen activated protein kinase (MAPK) activity, closely associated with induction of MMP-9 under stress condition, was markedly reduced by NB treatment, which implies that modulation of p38MAPK by nobiletin is responsible for reduction of MMP9 expression.	nobiletin	213-222	mitogen-activated protein kinase 14	Homo sapiens	10-46
24389490-6	2014	Sustained p38 mitogen activated protein kinase (MAPK) activity, closely associated with induction of MMP-9 under stress condition, was markedly reduced by NB treatment, which implies that modulation of p38MAPK by nobiletin is responsible for reduction of MMP9 expression.	nobiletin	213-222	matrix metallopeptidase 9	Homo sapiens	101-106
24389490-6	2014	Sustained p38 mitogen activated protein kinase (MAPK) activity, closely associated with induction of MMP-9 under stress condition, was markedly reduced by NB treatment, which implies that modulation of p38MAPK by nobiletin is responsible for reduction of MMP9 expression.	nobiletin	213-222	matrix metallopeptidase 9	Homo sapiens	255-259
24316474-9	2014	Likewise, CaMKII- and cAMP kinase-dependent TH phosphorylation was significantly restored by nobiletin treatment.	nobiletin	93-102	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	10-16
24316474-10	2014	MPTP-induced reduction of dopamine contents in the striatum and hippocampal CA1 region was improved by nobiletin administration (50mg/kg i.p.).	nobiletin	103-112	carbonic anhydrase 1	Mus musculus	76-79
24316474-11	2014	Acute intraperitoneal administration of nobiletin also enhanced dopamine release in striatum and hippocampal CA1, an effect partially inhibited by treatment with nifedipine (a L-type Ca(2+) channel inhibitor) or NNC 55-0396 (a T-type Ca(2+) channel inhibitor) and completely abolished by combined treatment with both.	nobiletin	40-49	carbonic anhydrase 1	Mus musculus	109-112
24964900-3	2014	For the first time, we have shown that nobiletin significantly upregulated mRNA expression of the NMDA receptor subunits NR1, NR2A, and NR2B in PC12D cells.	nobiletin	39-48	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	126-130
24964900-3	2014	For the first time, we have shown that nobiletin significantly upregulated mRNA expression of the NMDA receptor subunits NR1, NR2A, and NR2B in PC12D cells.	nobiletin	39-48	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	136-140
24964900-5	2014	Our results indicate that nobiletin modulates the expression of essential genes for learning and memory by activating the CREB signaling pathway, and suggest that this action mechanism of nobiletin plays a crucial role in improving NMDA receptor antagonist-induced learning impairment in model animals with dementia.	nobiletin	26-35	cAMP responsive element binding protein 1	Rattus norvegicus	122-126
23958298-11	2013	CONCLUSIONS: The suppression of iNOS induction by nobiletin suggests that nobiletin may be responsible for the anti-inflammatory effects of citrus peels and have a therapeutic potential for liver diseases.	nobiletin	50-59	nitric oxide synthase 2	Rattus norvegicus	32-36
24492414-5	2014	Nobiletin (1.0 - 100 muM), a citrus polymethoxy flavone, enhanced (14)C-catecholamine synthesis through the phosphorylation of Ser19 and Ser40 of tyrosine hydroxylase, which was associated with (45)Ca(2+) influx and catecholamine secretion.	nobiletin	0-9	latexin	Homo sapiens	21-24
24492414-7	2014	Daidzein as well as nobiletin (>= 1.0 muM) inhibited catecholamine synthesis and secretion induced by acetylcholine, a physiological secretagogue.	nobiletin	20-29	latexin	Homo sapiens	41-44
23958298-3	2013	Nobiletin may suppress the induction of inducible nitric oxide synthase (iNOS), which synthesizes the inflammatory mediator nitric oxide (NO) in hepatocytes.	nobiletin	0-9	nitric oxide synthase 2	Rattus norvegicus	73-77
23958298-11	2013	CONCLUSIONS: The suppression of iNOS induction by nobiletin suggests that nobiletin may be responsible for the anti-inflammatory effects of citrus peels and have a therapeutic potential for liver diseases.	nobiletin	74-83	nitric oxide synthase 2	Rattus norvegicus	32-36
23774476-7	2013	Therefore, the protective and ameliorative effects of nobiletin on neuronal degeneration and impaired memory, which several studies using animal models have demonstrated, might arise in part from nobiletin"s ability to repress TXNIP expression.	nobiletin	54-63	thioredoxin interacting protein	Homo sapiens	227-232
23774476-0	2013	Suppressive effect of nobiletin, a citrus polymethoxyflavonoid that downregulates thioredoxin-interacting protein expression, on tunicamycin-induced apoptosis in SK-N-SH human neuroblastoma cells.	nobiletin	22-31	thioredoxin interacting protein	Homo sapiens	82-113
23774476-4	2013	Moreover, we evaluated the effects of nobiletin, a citrus polymethoxyflavonoid, on tunicamycin-induced apoptosis and TXNIP expression in SK-N-SH cells, because we reported previously that this flavonoid might be able to reduce TXNIP expression.	nobiletin	38-47	thioredoxin interacting protein	Homo sapiens	117-122
23774476-6	2013	In addition, we proved that the ability of 100 muM nobiletin treatment to reduce TXNIP expression is exerted from 3h after the onset of treatment.	nobiletin	51-60	thioredoxin interacting protein	Homo sapiens	81-86
22678994-6	2013	Polymethoxylated flavones such as nobiletin and tangeretin were found as the active compounds responsible for CPE effects on  Psim .	nobiletin	34-43	carboxypeptidase E	Mus musculus	110-113
23644141-0	2013	Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat.	nobiletin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	66-69
23644141-0	2013	Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat.	nobiletin	0-9	cAMP responsive element binding protein 1	Rattus norvegicus	73-77
23644141-0	2013	Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat.	nobiletin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	79-83
23644141-0	2013	Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat.	nobiletin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	88-93
23644141-12	2013	Immunohistochemistry, western blot and RT-qPCR analysis indicated that NOB dramatically promoted the activities of Akt, CREB, BDNF and Bcl-2 (P<0.05).	nobiletin	71-74	AKT serine/threonine kinase 1	Rattus norvegicus	115-118
23644141-12	2013	Immunohistochemistry, western blot and RT-qPCR analysis indicated that NOB dramatically promoted the activities of Akt, CREB, BDNF and Bcl-2 (P<0.05).	nobiletin	71-74	cAMP responsive element binding protein 1	Rattus norvegicus	120-124
23644141-12	2013	Immunohistochemistry, western blot and RT-qPCR analysis indicated that NOB dramatically promoted the activities of Akt, CREB, BDNF and Bcl-2 (P<0.05).	nobiletin	71-74	brain-derived neurotrophic factor	Rattus norvegicus	126-130
23644141-12	2013	Immunohistochemistry, western blot and RT-qPCR analysis indicated that NOB dramatically promoted the activities of Akt, CREB, BDNF and Bcl-2 (P<0.05).	nobiletin	71-74	BCL2, apoptosis regulator	Rattus norvegicus	135-140
23644141-14	2013	On the basis of these findings, we concluded that NOB protected the brain from ischemic damage and it maybe through activating the Akt/CREB signaling pathway and ameliorating BBB permeability.	nobiletin	50-53	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
23644141-14	2013	On the basis of these findings, we concluded that NOB protected the brain from ischemic damage and it maybe through activating the Akt/CREB signaling pathway and ameliorating BBB permeability.	nobiletin	50-53	cAMP responsive element binding protein 1	Rattus norvegicus	135-139
23572161-5	2013	The present study investigated the effects of nobiletin (a polymethoxy flavonoid contained in the rind of citrus fruits) on TAFI gene (CPB2) and TAFI antigen expression in cultured human hepatoma HepG2 cells.	nobiletin	46-55	carboxypeptidase B2	Homo sapiens	135-139
23572161-8	2013	Using nobiletin-treated cells that were transfected with a luciferase CPB2 promoter reporter plasmid, activity decreased to half of that in untreated control cells.	nobiletin	6-15	carboxypeptidase B2	Homo sapiens	70-74
23572161-11	2013	ChIP assays showed that c-Jun bound to the ~ -119 bp to -99 bp region of the CPB2 promoter and that the amount of the immunocomplex decreased after nobiletin treatment.	nobiletin	148-157	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-29
23572161-11	2013	ChIP assays showed that c-Jun bound to the ~ -119 bp to -99 bp region of the CPB2 promoter and that the amount of the immunocomplex decreased after nobiletin treatment.	nobiletin	148-157	carboxypeptidase B2	Homo sapiens	77-81
23572161-12	2013	Therefore, nobiletin-induced repression of CPB2 transcription might involve AP-1 inhibition and/or prevention of AP-1 binding in a specific region on the CPB2 gene in HepG2 cells.	nobiletin	11-20	carboxypeptidase B2	Homo sapiens	43-47
23572161-12	2013	Therefore, nobiletin-induced repression of CPB2 transcription might involve AP-1 inhibition and/or prevention of AP-1 binding in a specific region on the CPB2 gene in HepG2 cells.	nobiletin	11-20	carboxypeptidase B2	Homo sapiens	154-158
23984517-7	2013	Nobiletin may be a therapeutic lead compound in treating CFTR-related diseases including disseminated bronchiectasis.	nobiletin	0-9	CF transmembrane conductance regulator	Homo sapiens	57-61
23537747-0	2013	Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.	nobiletin	0-9	mitogen-activated protein kinase 1	Homo sapiens	41-44
23537747-0	2013	Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	54-57
23537747-0	2013	Nobiletin attenuates metastasis via both ERK and PI3K/Akt pathways in HGF-treated liver cancer HepG2 cells.	nobiletin	0-9	hepatocyte growth factor	Homo sapiens	70-73
23537747-2	2013	We use HGF as an invasive inducer of human HepG2 cells to investigate the effect of four flavones including apigenin, tricetin, tangeretin, and nobiletin on HGF/c-Met-mediated tumor invasion and metastasis.	nobiletin	144-153	hepatocyte growth factor	Homo sapiens	157-160
23537747-2	2013	We use HGF as an invasive inducer of human HepG2 cells to investigate the effect of four flavones including apigenin, tricetin, tangeretin, and nobiletin on HGF/c-Met-mediated tumor invasion and metastasis.	nobiletin	144-153	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	161-166
23537747-3	2013	Among them, nobiletin markedly inhibited HGF-induced the abilities of the adhesion, invasion, and migration by cell-matrix adhesion assay and transwell-chamber invasion/migration assay under non-cytotoxic concentrations.	nobiletin	12-21	hepatocyte growth factor	Homo sapiens	41-44
23537747-5	2013	Furthermore, nobiletin could inhibit HGF-induced the membrane localization of phosphorylated c-Met, ERK2, and Akt, but not phosphorylated JNK1/2 and p38.	nobiletin	13-22	hepatocyte growth factor	Homo sapiens	37-40
23537747-5	2013	Furthermore, nobiletin could inhibit HGF-induced the membrane localization of phosphorylated c-Met, ERK2, and Akt, but not phosphorylated JNK1/2 and p38.	nobiletin	13-22	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	93-98
23537747-5	2013	Furthermore, nobiletin could inhibit HGF-induced the membrane localization of phosphorylated c-Met, ERK2, and Akt, but not phosphorylated JNK1/2 and p38.	nobiletin	13-22	mitogen-activated protein kinase 1	Homo sapiens	100-104
23537747-5	2013	Furthermore, nobiletin could inhibit HGF-induced the membrane localization of phosphorylated c-Met, ERK2, and Akt, but not phosphorylated JNK1/2 and p38.	nobiletin	13-22	AKT serine/threonine kinase 1	Homo sapiens	110-113
23537747-6	2013	Next, nobiletin significantly decreased the levels of phospho-ERK2 and phospho-Akt in ERK2 or Akt siRNA-transfected cells concomitantly with a marked reduction on cell invasion and migration.	nobiletin	6-15	mitogen-activated protein kinase 1	Homo sapiens	62-66
23537747-6	2013	Next, nobiletin significantly decreased the levels of phospho-ERK2 and phospho-Akt in ERK2 or Akt siRNA-transfected cells concomitantly with a marked reduction on cell invasion and migration.	nobiletin	6-15	AKT serine/threonine kinase 1	Homo sapiens	79-82
23537747-6	2013	Next, nobiletin significantly decreased the levels of phospho-ERK2 and phospho-Akt in ERK2 or Akt siRNA-transfected cells concomitantly with a marked reduction on cell invasion and migration.	nobiletin	6-15	mitogen-activated protein kinase 1	Homo sapiens	86-90
23537747-6	2013	Next, nobiletin significantly decreased the levels of phospho-ERK2 and phospho-Akt in ERK2 or Akt siRNA-transfected cells concomitantly with a marked reduction on cell invasion and migration.	nobiletin	6-15	AKT serine/threonine kinase 1	Homo sapiens	94-97
23537747-7	2013	In conclusion, nobiletin attenuates HGF-induced HepG2 cells metastasis involving both ERK and PI3K/Akt pathways and are potentially useful as anti-metastatic agents for the treatment of hepatoma.	nobiletin	15-24	hepatocyte growth factor	Homo sapiens	36-39
23537747-7	2013	In conclusion, nobiletin attenuates HGF-induced HepG2 cells metastasis involving both ERK and PI3K/Akt pathways and are potentially useful as anti-metastatic agents for the treatment of hepatoma.	nobiletin	15-24	mitogen-activated protein kinase 1	Homo sapiens	86-89
23537747-7	2013	In conclusion, nobiletin attenuates HGF-induced HepG2 cells metastasis involving both ERK and PI3K/Akt pathways and are potentially useful as anti-metastatic agents for the treatment of hepatoma.	nobiletin	15-24	AKT serine/threonine kinase 1	Homo sapiens	99-102
23573124-0	2013	Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress.	nobiletin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	50-54
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	latexin	Homo sapiens	56-59
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	DNA damage inducible transcript 3	Homo sapiens	207-212
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	tribbles pseudokinase 3	Homo sapiens	214-219
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	225-229
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	cyclin A2	Homo sapiens	345-350
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	cyclin E2	Homo sapiens	352-357
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	E2F transcription factor 8	Homo sapiens	363-367
23321314-3	2013	In all three cell lines, treatments with nobiletin (100 muM) for 24 h resulted in more than 200% increases in the expression levels of five genes, including the endoplasmic reticulum stress-responsive genes Ddit3, Trib3, and Asns, and in less than 50% decreases in the expression levels of seven genes, including the cell cycle-regulating genes Ccna2, Ccne2, and E2f8 and the oxidative stress-promoting gene Txnip.	nobiletin	41-50	thioredoxin interacting protein	Homo sapiens	408-413
23573124-13	2013	Taken together, these findings suggest that nobiletin produces rapidly acting antidepressant-like responses in the CUMS and imply that BDNF-TrkB pathway may play an important role in the antidepressant-like effect of nobiletin.	nobiletin	217-226	brain-derived neurotrophic factor	Rattus norvegicus	135-139
23573124-13	2013	Taken together, these findings suggest that nobiletin produces rapidly acting antidepressant-like responses in the CUMS and imply that BDNF-TrkB pathway may play an important role in the antidepressant-like effect of nobiletin.	nobiletin	217-226	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	140-144
23546290-8	2013	Third, western blotting revealed that nobiletin showed inhibitory effects on MEK and ERK phopsphorylation levels in a concentration-dependent manner.	nobiletin	38-47	Eph receptor B1	Rattus norvegicus	85-88
23546290-9	2013	Finally, such an inhibitory effect on the level of ERK phosphorylation by nobiletin was appreciably prevented by Go6976, a selective inhibitor of conventional protein kinase Cs (PKCs) showing Ca(2+)-sensitivity, while GF109203X, a general inhibitor for PKCs, and BAPTA, a cell-permeable Ca(2+) chelator, to a lesser extent, suppressed a reduction of the phosphorylation.	nobiletin	74-83	Eph receptor B1	Rattus norvegicus	51-54
23546290-10	2013	These findings suggest that the proliferation of C6 cells is Ras- and MEK/ERK signaling-dependent, and that nobiletin suppresses the cell proliferation by inhibiting Ras activity and MEK/ERK signaling cascade probably via a Ca(2+)-sensitive PKC-dependent mechanism.	nobiletin	108-117	Eph receptor B1	Rattus norvegicus	187-190
23573124-0	2013	Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress.	nobiletin	0-9	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	56-60
23573124-0	2013	Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress.	nobiletin	0-9	synapsin I	Rattus norvegicus	66-76
23441616-0	2013	Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells.	nobiletin	0-9	tumor protein p53	Homo sapiens	97-100
23441616-1	2013	Nobiletin is a typical polymethoxyl flavone from citrus fruits that has anticancer properties, but the molecular mechanism of its inhibitory effects on the growth of p53-mutated SNU-16 human gastric cancer cells has not been explored.	nobiletin	0-9	tumor protein p53	Homo sapiens	166-169
23441616-3	2013	Nobiletin induced the death of SNU-16 cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of fragmented nuclei, an increase in the Bax/Bcl-2 ratio, the proteolytic activation of caspase-9, an increase in caspase-3 activity, and the degradation of poly(ADP-ribose) polymerase (PARP) protein.	nobiletin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	186-189
23441616-3	2013	Nobiletin induced the death of SNU-16 cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of fragmented nuclei, an increase in the Bax/Bcl-2 ratio, the proteolytic activation of caspase-9, an increase in caspase-3 activity, and the degradation of poly(ADP-ribose) polymerase (PARP) protein.	nobiletin	0-9	BCL2 apoptosis regulator	Homo sapiens	190-195
23441616-3	2013	Nobiletin induced the death of SNU-16 cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of fragmented nuclei, an increase in the Bax/Bcl-2 ratio, the proteolytic activation of caspase-9, an increase in caspase-3 activity, and the degradation of poly(ADP-ribose) polymerase (PARP) protein.	nobiletin	0-9	caspase 9	Homo sapiens	233-242
23441616-3	2013	Nobiletin induced the death of SNU-16 cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of fragmented nuclei, an increase in the Bax/Bcl-2 ratio, the proteolytic activation of caspase-9, an increase in caspase-3 activity, and the degradation of poly(ADP-ribose) polymerase (PARP) protein.	nobiletin	0-9	caspase 3	Homo sapiens	259-268
23441616-3	2013	Nobiletin induced the death of SNU-16 cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of fragmented nuclei, an increase in the Bax/Bcl-2 ratio, the proteolytic activation of caspase-9, an increase in caspase-3 activity, and the degradation of poly(ADP-ribose) polymerase (PARP) protein.	nobiletin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	302-329
23441616-3	2013	Nobiletin induced the death of SNU-16 cells through apoptosis, as evidenced by the increased cell population in the sub-G1 phase, the appearance of fragmented nuclei, an increase in the Bax/Bcl-2 ratio, the proteolytic activation of caspase-9, an increase in caspase-3 activity, and the degradation of poly(ADP-ribose) polymerase (PARP) protein.	nobiletin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	331-335
23441616-5	2013	The expression of p53 protein increased after treatment with 5-FU, but not nobiletin, whereas the expression of p21 (WAF1/CIP1)  protein increased after treatment with nobiletin, but not 5-FU.	nobiletin	168-177	cyclin dependent kinase inhibitor 1A	Homo sapiens	112-115
23441616-5	2013	The expression of p53 protein increased after treatment with 5-FU, but not nobiletin, whereas the expression of p21 (WAF1/CIP1)  protein increased after treatment with nobiletin, but not 5-FU.	nobiletin	168-177	cyclin dependent kinase inhibitor 1A	Homo sapiens	117-126
23441616-7	2013	The results of this study suggest the potential application of nobiletin to the enhancement of 5-FU efficiency in p53 mutant tumors.	nobiletin	63-72	tumor protein p53	Homo sapiens	114-117
22853317-10	2012	Nobiletin also suppressed MMP-9 enzymatic activity and tumor cell invasion under noncytotoxic concentrations.	nobiletin	0-9	matrix metallopeptidase 9	Homo sapiens	26-31
23373222-4	2012	RESULT: Hesperidin and nobiletin contained in citrus flavonoids were found to effectively activate NMU2R.	nobiletin	23-32	neuromedin U receptor 2	Homo sapiens	99-104
23373222-6	2012	CONCLUSION: Hesperidin and nobiletin contained in citrus flavonoids can activate NMU2R.	nobiletin	27-36	neuromedin U receptor 2	Homo sapiens	81-86
22853317-13	2012	DISCUSSION AND CONCLUSION: Our results indicate, for the first time, that nobiletin is a novel blocker of CXCR4 and MMP-9 expressions and thus has the potential to suppress metastasis of breast cancer.	nobiletin	74-83	C-X-C motif chemokine receptor 4	Homo sapiens	106-111
22853317-13	2012	DISCUSSION AND CONCLUSION: Our results indicate, for the first time, that nobiletin is a novel blocker of CXCR4 and MMP-9 expressions and thus has the potential to suppress metastasis of breast cancer.	nobiletin	74-83	matrix metallopeptidase 9	Homo sapiens	116-121
22743247-5	2012	Among the three CYP1 isoforms, CYP1A1 exhibited the highest rate of metabolism of nobiletin in recombinant CYP microsomal enzymes.	nobiletin	82-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	16-20
22743247-5	2012	Among the three CYP1 isoforms, CYP1A1 exhibited the highest rate of metabolism of nobiletin in recombinant CYP microsomal enzymes.	nobiletin	82-91	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
22743247-7	2012	In addition nobiletin induced CYP1 enzyme activity, CYP1A1 protein and CYP1B1 mRNA levels in MCF7 cells at a concentration dependent manner.	nobiletin	12-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-34
22743247-7	2012	In addition nobiletin induced CYP1 enzyme activity, CYP1A1 protein and CYP1B1 mRNA levels in MCF7 cells at a concentration dependent manner.	nobiletin	12-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	52-58
22743247-7	2012	In addition nobiletin induced CYP1 enzyme activity, CYP1A1 protein and CYP1B1 mRNA levels in MCF7 cells at a concentration dependent manner.	nobiletin	12-21	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	71-77
22743247-8	2012	MTT assays in MCF7 cells further revealed that nobiletin exhibited significantly lower IC50 (44 muM) compared to cells treated with nobiletin and CYP1A1 inhibitor (69 muM).	nobiletin	47-56	latexin	Homo sapiens	96-99
22743247-8	2012	MTT assays in MCF7 cells further revealed that nobiletin exhibited significantly lower IC50 (44 muM) compared to cells treated with nobiletin and CYP1A1 inhibitor (69 muM).	nobiletin	47-56	latexin	Homo sapiens	167-170
22743247-10	2012	Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation.	nobiletin	60-69	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	181-187
22743247-10	2012	Taken together the data suggests that the dietary flavonoid nobiletin induces its own metabolism and in turn enhances its cytostatic effect in MCF7 breast adenocarcinoma cells, via CYP1A1 and CYP1B1 upregulation.	nobiletin	60-69	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	192-198
22172985-7	2012	In addition, nobiletin decreased the phosphorylation of cAMP-response element-binding protein (CREB) and strongly enhanced the phophorylation of signal transducer and activator of transcription (STAT) 5.	nobiletin	13-22	cAMP responsive element binding protein 1	Mus musculus	56-93
22172985-7	2012	In addition, nobiletin decreased the phosphorylation of cAMP-response element-binding protein (CREB) and strongly enhanced the phophorylation of signal transducer and activator of transcription (STAT) 5.	nobiletin	13-22	cAMP responsive element binding protein 1	Mus musculus	95-99
22172985-7	2012	In addition, nobiletin decreased the phosphorylation of cAMP-response element-binding protein (CREB) and strongly enhanced the phophorylation of signal transducer and activator of transcription (STAT) 5.	nobiletin	13-22	signal transducer and activator of transcription 5A	Mus musculus	145-202
22064360-7	2012	NOB and DTF also activated the ERK, JNK, and Akt pathways in PC12 cells that had undergone serum starvation.	nobiletin	0-3	mitogen-activated protein kinase 8	Rattus norvegicus	36-39
22273151-8	2012	Nobiletin, a major active constituent of DCF, could induce apoptosis via the suppression of constitutive STAT3 activation.	nobiletin	0-9	signal transducer and activator of transcription 3	Homo sapiens	105-110
22064360-7	2012	NOB and DTF also activated the ERK, JNK, and Akt pathways in PC12 cells that had undergone serum starvation.	nobiletin	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
22064360-8	2012	Addition of pharmacological kinase inhibitors, U0126, SP600125, and LY294002, caused cytotoxicity and the last significantly attenuated NOB- and DTF-mediated antiapoptotic actions, indicating the involvement of PI3K/Akt signaling in their cytoprotective effects.	nobiletin	136-139	AKT serine/threonine kinase 1	Rattus norvegicus	216-219
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	nobiletin	80-89	latexin	Homo sapiens	220-223
22088202-3	2011	The results revealed that nobiletin markedly inhibited lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity and blocked the expression of adipogenic transcription factors, including peroxisome proliferator-activated receptors (PPARgamma) and CCAAT/enhancer binding proteins (C/EBPalpha).	nobiletin	26-35	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	78-112
22088202-3	2011	The results revealed that nobiletin markedly inhibited lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity and blocked the expression of adipogenic transcription factors, including peroxisome proliferator-activated receptors (PPARgamma) and CCAAT/enhancer binding proteins (C/EBPalpha).	nobiletin	26-35	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	114-118
22088202-3	2011	The results revealed that nobiletin markedly inhibited lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity and blocked the expression of adipogenic transcription factors, including peroxisome proliferator-activated receptors (PPARgamma) and CCAAT/enhancer binding proteins (C/EBPalpha).	nobiletin	26-35	peroxisome proliferator activated receptor gamma	Mus musculus	248-257
22088202-3	2011	The results revealed that nobiletin markedly inhibited lipid accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity and blocked the expression of adipogenic transcription factors, including peroxisome proliferator-activated receptors (PPARgamma) and CCAAT/enhancer binding proteins (C/EBPalpha).	nobiletin	26-35	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	296-306
22088202-6	2011	It was found that pretreatment with compound C, a cell permeable inhibitor of AMPK, abolished the inhibitory effects of nobiletin on PPARgamma expression.	nobiletin	120-129	peroxisome proliferator activated receptor gamma	Mus musculus	133-142
22088202-7	2011	The results suggest that nobiletin exerts antiadipogenic effects through modulation of the PPARgamma and AMPK signaling pathway and, therefore, may be a promising antiobesity agent.	nobiletin	25-34	peroxisome proliferator activated receptor gamma	Mus musculus	91-100
21723726-0	2011	Nobiletin metabolites: synthesis and inhibitory activity against matrix metalloproteinase-9 production.	nobiletin	0-9	matrix metallopeptidase 9	Homo sapiens	65-91
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	nobiletin	80-89	latexin	Homo sapiens	220-223
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	nobiletin	80-89	low density lipoprotein receptor	Homo sapiens	286-298
21471511-0	2011	Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.	nobiletin	0-9	CD320 antigen	Mus musculus	21-25
21471511-0	2011	Nobiletin attenuates VLDL overproduction, dyslipidemia, and atherosclerosis in mice with diet-induced insulin resistance.	nobiletin	0-9	insulin	Homo sapiens	102-109
21471511-10	2011	In fat-fed Ldlr(-/-) mice, nobiletin attenuated dyslipidemia through a reduction in VLDL-triglyceride (TG) secretion.	nobiletin	27-36	low density lipoprotein receptor	Mus musculus	11-15
21471511-10	2011	In fat-fed Ldlr(-/-) mice, nobiletin attenuated dyslipidemia through a reduction in VLDL-triglyceride (TG) secretion.	nobiletin	27-36	CD320 antigen	Mus musculus	84-88
21471511-11	2011	Nobiletin prevented hepatic TG accumulation, increased expression of Pgc1alpha and Cpt1alpha, and enhanced fatty acid beta-oxidation.	nobiletin	0-9	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	69-78
21471511-11	2011	Nobiletin prevented hepatic TG accumulation, increased expression of Pgc1alpha and Cpt1alpha, and enhanced fatty acid beta-oxidation.	nobiletin	0-9	carnitine palmitoyltransferase 1a, liver	Mus musculus	83-92
21471511-13	2011	Nobiletin increased hepatic and peripheral insulin sensitivity and glucose tolerance and dramatically attenuated atherosclerosis in the aortic sinus.	nobiletin	0-9	insulin	Homo sapiens	43-50
21225617-1	2011	SCOPE: Nobiletin, a polymethoxyflavone from the peel of citrus fruits, has been reported to inhibit modified LDL uptake in macrophages and enhance hepatic LDL receptor expression and activity.	nobiletin	7-16	low density lipoprotein receptor	Homo sapiens	155-167
21258168-0	2011	Nobiletin, a polymethoxy flavonoid, suppresses bone resorption by inhibiting NFkappaB-dependent prostaglandin E synthesis in osteoblasts and prevents bone loss due to estrogen deficiency.	nobiletin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-85
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	nobiletin	80-89	apolipoprotein B	Homo sapiens	110-114
21425871-3	2011	Results show that two polymethoxylated citrus flavonoids (PMFs), tangeretin and nobiletin, potently inhibited apoB secretion (IC(50) = 13 and 29 muM, respectively) and modestly inhibited CH synthesis (IC(50) = 49 and 68 muM) and TG synthesis (IC(50) = 14 and 73 muM), without effecting LDL-receptor activity.	nobiletin	80-89	latexin	Homo sapiens	145-148
21258168-3	2011	In vitro, nobiletin suppressed osteoclast formation and bone resorption induced by interleukin (IL)-1.	nobiletin	10-19	interleukin 1 complex	Mus musculus	83-101
21258168-4	2011	Nobiletin suppressed the expression of cyclooxygenase-2, NFkappaB-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts.	nobiletin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	39-55
21258168-4	2011	Nobiletin suppressed the expression of cyclooxygenase-2, NFkappaB-dependent transcription, and prostaglandin E (PGE) production induced by IL-1 in osteoblasts.	nobiletin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-65
21747212-0	2011	Honeybee royal jelly and nobiletin stimulate CRE-mediated transcription in ERK-independent and -dependent fashions, respectively, in PC12D cells.	nobiletin	25-34	Eph receptor B1	Rattus norvegicus	75-78
20963626-0	2011	Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.	nobiletin	0-9	protein tyrosine kinase 2	Homo sapiens	75-78
20963626-0	2011	Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	84-87
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	protein tyrosine kinase 2	Homo sapiens	59-80
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	protein tyrosine kinase 2	Homo sapiens	82-85
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	AKT serine/threonine kinase 1	Homo sapiens	117-120
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	122-130
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	matrix metallopeptidase 2	Homo sapiens	234-260
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	matrix metallopeptidase 2	Homo sapiens	262-267
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	matrix metallopeptidase 2	Homo sapiens	274-300
20963626-3	2011	Data also showed nobiletin could inhibit the activation of focal adhesion kinase (FAK) and phosphoinositide-3-kinase/Akt (PI3K/Akt) involved in the downregulation of the enzyme activities, protein expressions, messenger RNA levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-2 (MMP-9).	nobiletin	17-26	matrix metallopeptidase 9	Homo sapiens	302-307
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	protein tyrosine kinase 2	Homo sapiens	49-52
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	AKT serine/threonine kinase 1	Homo sapiens	58-61
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	123-128
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	Rac family small GTPase 1	Homo sapiens	130-135
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	cell division cycle 42	Homo sapiens	137-142
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	ras homolog family member A	Homo sapiens	148-152
20963626-4	2011	Also, our data revealed that nobiletin inhibited FAK/PI3K/Akt with concurrent reduction in the protein expressions of Ras, c-Raf, Rac-1, Cdc42, and RhoA by western blotting, whereas the protein level of RhoB increased progressively.	nobiletin	29-38	ras homolog family member B	Homo sapiens	203-207
20963626-5	2011	Otherwise, nobiletin-treated AGS cells showed tremendously decreased in the phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), the nuclear level of NF-kappaB, and the binding ability of NF-kappaB to NF-kappaB response element.	nobiletin	11-20	NFKB inhibitor alpha	Homo sapiens	137-149
20963626-5	2011	Otherwise, nobiletin-treated AGS cells showed tremendously decreased in the phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), the nuclear level of NF-kappaB, and the binding ability of NF-kappaB to NF-kappaB response element.	nobiletin	11-20	nuclear factor kappa B subunit 1	Homo sapiens	173-182
20963626-5	2011	Otherwise, nobiletin-treated AGS cells showed tremendously decreased in the phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), the nuclear level of NF-kappaB, and the binding ability of NF-kappaB to NF-kappaB response element.	nobiletin	11-20	nuclear factor kappa B subunit 1	Homo sapiens	211-220
20963626-5	2011	Otherwise, nobiletin-treated AGS cells showed tremendously decreased in the phosphorylation and degradation of inhibitor of kappaBalpha (IkappaBalpha), the nuclear level of NF-kappaB, and the binding ability of NF-kappaB to NF-kappaB response element.	nobiletin	11-20	nuclear factor kappa B subunit 1	Homo sapiens	211-220
20963626-6	2011	Furthermore, nobiletin significantly decreased the levels of phospho-Akt and MMP-2/9 in Akt1-cDNA-transfected cells concomitantly with a marked reduction in cell invasion and migration.	nobiletin	13-22	AKT serine/threonine kinase 1	Homo sapiens	69-72
20963626-6	2011	Furthermore, nobiletin significantly decreased the levels of phospho-Akt and MMP-2/9 in Akt1-cDNA-transfected cells concomitantly with a marked reduction in cell invasion and migration.	nobiletin	13-22	matrix metallopeptidase 2	Homo sapiens	77-84
20963626-6	2011	Furthermore, nobiletin significantly decreased the levels of phospho-Akt and MMP-2/9 in Akt1-cDNA-transfected cells concomitantly with a marked reduction in cell invasion and migration.	nobiletin	13-22	AKT serine/threonine kinase 1	Homo sapiens	88-92
20670297-8	2010	Furthermore, nobiletin inhibited angiogenic differentiation induced by vascular endothelial growth factor and FGF, an in vitro angiogenesis model.	nobiletin	13-22	vascular endothelial growth factor A	Homo sapiens	71-105
20691757-4	2010	The results showed that naringin and nobiletin inhibited the decrease of cell viability (MTT reduction), prevented membrane damage (LDH release), scavenged ROS formation, reduced caspase-3 activity, and attenuated the decrease of mitochondrial membrane potential (MMP), respectively, in H(2)O(2)-induced PC12 cells.	nobiletin	37-46	caspase 3	Rattus norvegicus	179-188
20135704-0	2010	Study of nobiletin binding to bovine serum albumin by capillary electrophoresis-frontal analysis and circular dichroism.	nobiletin	9-18	albumin	Homo sapiens	37-50
20135704-3	2010	In this work, for the first time, detection of NOB at near-physiological conditions was accomplished by means of capillary electrophoresis-frontal analysis (CE-FA), and then the binding constants of NOB with bovine serum albumin (BSA) at the same conditions were determined.	nobiletin	47-50	albumin	Homo sapiens	215-228
20144590-8	2010	Taken together, the present results suggest that nobiletin improved the hyperglycemia and insulin resistance in obese diabetic ob/ob mice by regulating expression of Glut1 and Glut4 in WAT and muscle, and expression of adipokines in WAT.	nobiletin	49-58	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	166-171
20144590-8	2010	Taken together, the present results suggest that nobiletin improved the hyperglycemia and insulin resistance in obese diabetic ob/ob mice by regulating expression of Glut1 and Glut4 in WAT and muscle, and expression of adipokines in WAT.	nobiletin	49-58	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	176-181
20354348-6	2010	Nobiletin suppressed GalN/LPS-induced increases in plasma tumor necrosis factor (TNF)-alpha and nitric oxide (NO) concentrations and hepatic mRNA levels for inducible NO synthase and DNA fragmentation.	nobiletin	0-9	tumor necrosis factor	Rattus norvegicus	58-91
20354348-6	2010	Nobiletin suppressed GalN/LPS-induced increases in plasma tumor necrosis factor (TNF)-alpha and nitric oxide (NO) concentrations and hepatic mRNA levels for inducible NO synthase and DNA fragmentation.	nobiletin	0-9	nitric oxide synthase 2	Rattus norvegicus	157-178
20354348-7	2010	These results suggest that nobiletin suppressed GalN/LPS-induced liver injury at least by suppressing the production of both TNF-alpha and NO.	nobiletin	27-36	tumor necrosis factor	Rattus norvegicus	125-134
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	nobiletin	11-20	mitogen-activated protein kinase 1	Mus musculus	72-75
19646972-0	2009	Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.	nobiletin	0-9	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	94-100
19646972-0	2009	Nobiletin improves brain ischemia-induced learning and memory deficits through stimulation of CaMKII and CREB phosphorylation.	nobiletin	0-9	cAMP responsive element binding protein 1	Mus musculus	105-109
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	51-57
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	microtubule-associated protein 2	Mus musculus	59-63
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	68-73
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	carbonic anhydrase 1	Mus musculus	108-111
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	mitogen-activated protein kinase 1	Mus musculus	155-158
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	cAMP responsive element binding protein 1	Mus musculus	163-167
19646972-8	2009	The nobiletin treatment prevented the reduction in CaMKII, MAP2 and GluR1 protein levels in the hippocampal CA1 region, accompanied by restoration of both ERK and CREB phosphorylation and CaMKII autophosphorylation.	nobiletin	4-13	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	188-194
19646972-9	2009	Consistent with the restored CaMKII and ERK phosphorylation, an electrophysiological study showed that the impaired hippocampal long-term potentiation (LTP) observed in the 5-min ischemic mice was significantly improved by the nobiletin treatment.	nobiletin	227-236	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	29-35
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	nobiletin	11-20	cAMP responsive element binding protein 1	Mus musculus	76-80
19601643-0	2009	4"-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade.	nobiletin	11-20	mitogen-activated protein kinase 1	Mus musculus	184-187
19601643-8	2009	Therefore, these results suggest that 4"-demethylnobiletin, a bioactive metabolite of nobiletin, may serve as a potential therapeutic agent, at least, for memory disorders associated with a dysregulated NMDA receptor ERK signaling, like nobiletin.	nobiletin	49-58	mitogen-activated protein kinase 1	Mus musculus	217-220
19601643-8	2009	Therefore, these results suggest that 4"-demethylnobiletin, a bioactive metabolite of nobiletin, may serve as a potential therapeutic agent, at least, for memory disorders associated with a dysregulated NMDA receptor ERK signaling, like nobiletin.	nobiletin	86-95	mitogen-activated protein kinase 1	Mus musculus	217-220
19486902-11	2009	These findings suggest that the preventing effect of nobiletin on angiotensin II-induced VSMCs proliferation is attributed, in part, to its inhibitory effect on Ca(2+)-dependent JNK activation in VSMCs.	nobiletin	53-62	angiotensinogen	Homo sapiens	66-80
19486902-11	2009	These findings suggest that the preventing effect of nobiletin on angiotensin II-induced VSMCs proliferation is attributed, in part, to its inhibitory effect on Ca(2+)-dependent JNK activation in VSMCs.	nobiletin	53-62	mitogen-activated protein kinase 8	Homo sapiens	178-181
19486902-0	2009	Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway.	nobiletin	0-9	mitogen-activated protein kinase 8	Homo sapiens	109-133
19486902-7	2009	While no effect on ERK1/2 and p38 MAPK, nobiletin markedly inhibited angiotensin II-induced activation of JNK.	nobiletin	40-49	angiotensinogen	Homo sapiens	69-83
19486902-7	2009	While no effect on ERK1/2 and p38 MAPK, nobiletin markedly inhibited angiotensin II-induced activation of JNK.	nobiletin	40-49	mitogen-activated protein kinase 8	Homo sapiens	106-109
19486902-9	2009	Nobiletin also attenuated both the intracellular Ca(2+) mobilization and the extracellular Ca(2+) influx induced by angiotensin II.	nobiletin	0-9	angiotensinogen	Homo sapiens	116-130
19486902-12	2009	Thus, inhibition of JNK by nobiletin may imply its usefulness for the treatment of cardiovascular diseases relevant to VSMCs growth.	nobiletin	27-36	mitogen-activated protein kinase 8	Homo sapiens	20-23
19771874-7	2009	Immunohistochemistry assay was used to determine the effect of nobiletin on VEGF expression and MVD, and CAM assay was used to detect the effect of nobiletin on vessel regeneration.	nobiletin	63-72	vascular endothelial growth factor A	Mus musculus	76-80
19771874-11	2009	The expression of CD34 in nobiletin low dose group and high dose group was lower than that in model control group (P < 0.05, P < 0.01).	nobiletin	26-35	CD34 antigen	Mus musculus	18-22
19771874-13	2009	CONCLUSION: Nobiletin inhibited the tumor growth and angiogenesis by reducing the VEGF expression of K562 cells xenograft in nude mice.	nobiletin	12-21	vascular endothelial growth factor A	Homo sapiens	82-86
19268587-2	2009	Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at a concentration of 10 microM.	nobiletin	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	159-170
18955043-4	2008	Nobiletin also increased the accumulation of calcein, a fluorescent substrate of MRP1, in KB/MRP cells.	nobiletin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	81-85
18955043-5	2008	The ATPase activity of P-glycoprotein was stimulated by auraptene and nobiletin.	nobiletin	70-79	dynein axonemal heavy chain 8	Homo sapiens	4-10
18955043-5	2008	The ATPase activity of P-glycoprotein was stimulated by auraptene and nobiletin.	nobiletin	70-79	ATP binding cassette subfamily B member 1	Homo sapiens	23-37
18541144-0	2008	Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.	nobiletin	0-9	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	88-109
18541144-2	2008	In this study, we examined the effects of nobiletin, a citrus polymethoxy flavone, on the expression and production of ADAMTS-4 and -5 in vitro and in vivo.	nobiletin	42-51	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	119-134
18541144-3	2008	Nobiletin (16-64muM) interfered with the interleukin (IL)-1beta-mediated ADAMTS-4 and -5 mRNA expression in cultured human synovial fibroblasts.	nobiletin	0-9	interleukin 1 beta	Homo sapiens	41-63
18541144-3	2008	Nobiletin (16-64muM) interfered with the interleukin (IL)-1beta-mediated ADAMTS-4 and -5 mRNA expression in cultured human synovial fibroblasts.	nobiletin	0-9	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	73-88
18541144-4	2008	Furthermore, intraperitoneal administration of nobiletin (15, 30, and 60mg/kg) also suppressed ADAMTS-4 and -5 mRNA expression in the joint tissues of collagen-induced arthritic (CIA) mice.	nobiletin	47-56	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	95-110
18567747-0	2008	The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells.	nobiletin	37-46	low density lipoprotein receptor	Homo sapiens	71-103
18261712-2	2008	In this study, we investigated the effect of nobiletin on bacterial lipopolysaccharide (LPS)-induced expression of tissue factor (TF), a trigger protein for the blood coagulation cascade, and studied the possible mechanism of TF transcriptional regulation.	nobiletin	45-54	coagulation factor III, tissue factor	Homo sapiens	115-128
18567747-9	2008	The sterol regulatory element (SRE) in the LDLR gene upstream region plays a crucial role, because mutation of this site strongly attenuated induction in response to hesperetin or nobiletin.	nobiletin	180-189	low density lipoprotein receptor	Homo sapiens	43-47
18379194-8	2008	Taken together, these results suggest that Nobiletin could induce p53-mediated cell cycle arrest and apoptosis via modulated the Bax:Bcl-2 protein ratio, is effective as a potent antitumor agent on lung tumors.	nobiletin	43-52	tumor protein p53	Homo sapiens	66-69
18379194-8	2008	Taken together, these results suggest that Nobiletin could induce p53-mediated cell cycle arrest and apoptosis via modulated the Bax:Bcl-2 protein ratio, is effective as a potent antitumor agent on lung tumors.	nobiletin	43-52	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
18379194-8	2008	Taken together, these results suggest that Nobiletin could induce p53-mediated cell cycle arrest and apoptosis via modulated the Bax:Bcl-2 protein ratio, is effective as a potent antitumor agent on lung tumors.	nobiletin	43-52	BCL2 apoptosis regulator	Homo sapiens	133-138
18375960-8	2008	Feeding with NOB abolished colonic malignancy and notably decreased the serum leptin level by 75%.	nobiletin	13-16	leptin	Mus musculus	78-84
18261712-2	2008	In this study, we investigated the effect of nobiletin on bacterial lipopolysaccharide (LPS)-induced expression of tissue factor (TF), a trigger protein for the blood coagulation cascade, and studied the possible mechanism of TF transcriptional regulation.	nobiletin	45-54	coagulation factor III, tissue factor	Homo sapiens	130-132
18261712-4	2008	However, pretreatment with nobiletin resulted in inhibition of LPS-induced expression of both TF protein and mRNA in a dose-dependent manner.	nobiletin	27-36	coagulation factor III, tissue factor	Homo sapiens	94-96
18261712-10	2008	These studies reveal that constitutive Sp1 activation is an essential event for transcriptional activation of TF, and nobiletin prevents LPS-induced TF expression by inhibiting NF-kappaB, AP-1, and Sp1 activation.	nobiletin	118-127	coagulation factor III, tissue factor	Homo sapiens	149-151
18261712-10	2008	These studies reveal that constitutive Sp1 activation is an essential event for transcriptional activation of TF, and nobiletin prevents LPS-induced TF expression by inhibiting NF-kappaB, AP-1, and Sp1 activation.	nobiletin	118-127	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	188-192
18053806-0	2008	A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells.	nobiletin	31-40	mitogen-activated protein kinase kinase 7	Homo sapiens	53-56
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	nobiletin	162-171	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	nobiletin	162-171	myelin basic protein	Homo sapiens	23-43
18053806-6	2008	MEK kinase assay using myelin basic protein (MBP) revealed that TPA-augmented MEK activity in HT-1080 cells and that the augmented MEK activity was diminished by nobiletin treatment.	nobiletin	162-171	myelin basic protein	Homo sapiens	45-48
18053806-7	2008	In addition, the decrease in MEK activity caused by nobiletin was found to inhibit the phosphorylation of extracellular regulated kinases (ERK), a downstream signaling factor for MEK.	nobiletin	52-61	mitogen-activated protein kinase kinase 7	Homo sapiens	29-32
18053806-7	2008	In addition, the decrease in MEK activity caused by nobiletin was found to inhibit the phosphorylation of extracellular regulated kinases (ERK), a downstream signaling factor for MEK.	nobiletin	52-61	mitogen-activated protein kinase kinase 7	Homo sapiens	179-182
18053806-8	2008	Furthermore, when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions, nobiletin was found to inhibit the MEK-mediated MBP phosphorylation.	nobiletin	70-79	mitogen-activated protein kinase kinase 7	Homo sapiens	47-50
18053806-8	2008	Furthermore, when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions, nobiletin was found to inhibit the MEK-mediated MBP phosphorylation.	nobiletin	70-79	mitogen-activated protein kinase kinase 7	Homo sapiens	143-146
18053806-8	2008	Furthermore, when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions, nobiletin was found to inhibit the MEK-mediated MBP phosphorylation.	nobiletin	70-79	myelin basic protein	Homo sapiens	156-159
18053806-8	2008	Furthermore, when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions, nobiletin was found to inhibit the MEK-mediated MBP phosphorylation.	nobiletin	108-117	mitogen-activated protein kinase kinase 7	Homo sapiens	47-50
18053806-8	2008	Furthermore, when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions, nobiletin was found to inhibit the MEK-mediated MBP phosphorylation.	nobiletin	108-117	mitogen-activated protein kinase kinase 7	Homo sapiens	143-146
18053806-8	2008	Furthermore, when an immunoprecipitated active MEK was incubated with nobiletin under cell-free conditions, nobiletin was found to inhibit the MEK-mediated MBP phosphorylation.	nobiletin	108-117	myelin basic protein	Homo sapiens	156-159
18053806-11	2008	Therefore, these results provide novel evidence that nobiletin directly inhibits MEK activity and decreases the sequential phosphorylation of ERK, exhibiting the antitumor metastatic activity by suppressing MMP expression in HT-1080 cells.	nobiletin	53-62	mitogen-activated protein kinase kinase 7	Homo sapiens	81-84
17644380-4	2007	Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.	nobiletin	53-62	nitric oxide synthase 2, inducible	Mus musculus	150-154
18057719-3	2007	Aerobical incubation with NADPH and animal liver microsomes transformed nobiletin to five metabolites, M-1, M-2, M-3, M-4 and M-5.	nobiletin	72-81	cholinergic receptor, muscarinic 4	Rattus norvegicus	118-121
17976577-0	2008	Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus.	nobiletin	0-9	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	137-142
17976577-2	2008	In the present study, using combined methods of biochemistry and electrophysiology, we examined the effects of nobiletin on phosphorylation of GluR1 receptor, the subunit of alpha-amino-3-hydroxy-5-methyl-D-aspartate (AMPA) receptors, and the receptor-mediated synaptic transmission in the hippocampus, a region implicated in memory formation, in culture and/or in slices.	nobiletin	111-120	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	143-148
17976577-6	2008	An increment of the phosphorylation of GluR1 receptor at Ser 845 was induced by nobiletin in the hippocampal slices as well.	nobiletin	80-89	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	39-44
17976577-7	2008	Furthermore, our electrophysiological analysis showed that nobiletin potentiated the AMPA receptor-mediated synaptic transmission at Schaffer collateral-CA1 pyramidal cell synapses in the hippocampal slices.	nobiletin	59-68	carbonic anhydrase 1	Mus musculus	153-156
17976577-9	2008	These findings suggest that nobiletin probably up-regulates synaptic transmission via the postsynaptic AMPA receptors at least partially by stimulation of PKA-mediated phosphorylation of GluR1 receptor in the hippocampus.	nobiletin	28-37	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	187-192
17644380-4	2007	Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.	nobiletin	53-62	cytochrome c oxidase II, mitochondrial	Mus musculus	156-161
17611060-5	2007	As reactive oxygen species (ROS) are also known to regulate the activation of NF-kappaB, we tested the effect of nobiletin on LPS-induced ROS generation.	nobiletin	113-122	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-87
17895593-4	2007	An 11-day administration of nobiletin rescued OBX-induced decrease in the density of AChE-staining and ChAT expression in the hippocampus.	nobiletin	28-37	acetylcholinesterase	Mus musculus	85-89
17433253-9	2007	These results suggested that nobiletin enhanced both differentiation and lipolysis of adipocyte through activation of signaling cascades mediated by cAMP/CREB.	nobiletin	29-38	cAMP responsive element binding protein 1	Homo sapiens	154-158
17617702-0	2007	Involvement of extracellular signal-regulated kinase in nobiletin-induced melanogenesis in murine B16/F10 melanoma cells.	nobiletin	56-65	mitogen-activated protein kinase 1	Mus musculus	15-52
17617702-2	2007	In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells.	nobiletin	29-38	tyrosinase	Mus musculus	69-79
17617702-3	2007	Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.	nobiletin	120-129	mitogen-activated protein kinase 1	Mus musculus	31-68
17617702-3	2007	Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.	nobiletin	120-129	mitogen-activated protein kinase 1	Mus musculus	70-73
17617702-3	2007	Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.	nobiletin	120-129	tyrosinase	Mus musculus	160-170
16253614-3	2005	Among the compounds, nobiletin most potently enhanced CRE-dependent transcription and neurite outgrowth by activating ERK/MAP kinase-dependent signalling to increase CREB phosphorylation.	nobiletin	21-30	cAMP responsive element binding protein 1	Rattus norvegicus	166-170
17039791-8	2006	Nobiletin could stimulate T lymphocyte transformation and the production of TNFalpha and IL-2.	nobiletin	0-9	tumor necrosis factor	Mus musculus	76-84
17039791-8	2006	Nobiletin could stimulate T lymphocyte transformation and the production of TNFalpha and IL-2.	nobiletin	0-9	interleukin 2	Mus musculus	89-93
17289833-0	2007	Nobiletin, a citrus flavonoid, reverses learning impairment associated with N-methyl-D-aspartate receptor antagonism by activation of extracellular signal-regulated kinase signaling.	nobiletin	0-9	Eph receptor B1	Rattus norvegicus	134-171
17289833-3	2007	Our recent studies have demonstrated that nobiletin, a polymethoxylated flavone from Citrus depressa, enhances cAMP/protein kinase A/ERK signaling in cultured rat hippocampal neurons and PC12D cells.	nobiletin	42-51	Eph receptor B1	Rattus norvegicus	133-136
17289833-6	2007	Western blot analysis also showed that nobiletin reversed MK-801-induced inhibition of learning-associated ERK activation in the hippocampus of the animals.	nobiletin	39-48	Eph receptor B1	Rattus norvegicus	107-110
17289833-7	2007	Furthermore, consistent with these results, in cultured rat hippocampal neurons, nobiletin restored MK-801-induced impairment of NMDA-stimulated phosphorylation of ERK in a concentration-dependent manner.	nobiletin	81-90	Eph receptor B1	Rattus norvegicus	164-167
17373552-1	2007	The inhibitory effects of nobiletin and hesperidin from citrus peel crude extracts on tyrosinase diphenolase activity are evaluated.	nobiletin	26-35	tyrosinase	Mus musculus	86-96
17373553-1	2007	The inhibitory effects of nobiletin and hesperidin from citrus peel crude extracts on tyrosinase diphenolase activity have been evaluated.	nobiletin	26-35	tyrosinase	Mus musculus	86-96
16337971-9	2006	Nobiletin (1.5 and 5.0 mg/kg given intraperitoneally) significantly reduced OVA-induced increases in eosinophils, remarkably lowered the level of Eotaxin in blood and broncho-alveolar lavage fluid (BALF) of asthmatic rats.	nobiletin	0-9	C-C motif chemokine ligand 11	Rattus norvegicus	146-153
16465400-8	2006	As a result, hesperetin and nobiletin suppressed the phosphorylation of Akt-1, direct downstream effector of phosphatidylinositol 3-kinase (PI3-K).	nobiletin	28-37	AKT serine/threonine kinase 1	Rattus norvegicus	72-77
16465400-8	2006	As a result, hesperetin and nobiletin suppressed the phosphorylation of Akt-1, direct downstream effector of phosphatidylinositol 3-kinase (PI3-K).	nobiletin	28-37	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	109-138
15585197-6	2005	This nobiletin-mediated effect was specific for SR-A and not a global effect on lipoprotein metabolism by the macrophage, as all four citrus flavonoids significantly reduce the metabolism of beta-VLDL, which is primarily taken up by macrophages via the LDL receptor.	nobiletin	5-14	macrophage scavenger receptor 1	Mus musculus	48-52
16317159-0	2005	Zingiberaceous and citrus constituents, 1"-acetoxychavicol acetate, zerumbone, auraptene, and nobiletin, suppress lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 murine macrophages through different modes of action.	nobiletin	94-103	prostaglandin-endoperoxide synthase 2	Mus musculus	141-157
15725655-0	2005	Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells.	nobiletin	0-9	matrix metallopeptidase 7	Homo sapiens	46-72
16229458-5	2005	Consistently, nobiletin caused a concentration-dependent enhancement of Erk/MAP kinase phosphorylation and a sustained increment of phosphorylation of MEK and Erk/MAP kinase, resulting in a stimulation of CREB phosphorylation and CRE-mediated transcription.	nobiletin	14-23	Eph receptor B1	Rattus norvegicus	72-75
16229458-5	2005	Consistently, nobiletin caused a concentration-dependent enhancement of Erk/MAP kinase phosphorylation and a sustained increment of phosphorylation of MEK and Erk/MAP kinase, resulting in a stimulation of CREB phosphorylation and CRE-mediated transcription.	nobiletin	14-23	Eph receptor B1	Rattus norvegicus	159-162
16229458-5	2005	Consistently, nobiletin caused a concentration-dependent enhancement of Erk/MAP kinase phosphorylation and a sustained increment of phosphorylation of MEK and Erk/MAP kinase, resulting in a stimulation of CREB phosphorylation and CRE-mediated transcription.	nobiletin	14-23	cAMP responsive element binding protein 1	Rattus norvegicus	205-209
16229458-9	2005	These results suggest that nobiletin induces neurite outgrowth by activating a cAMP/PKA/MEK/Erk/MAP kinase-dependent but not TrkA-dependent signaling pathway coupling with CRE-mediated gene transcription and may thus become a novel type of biochemical probe for elucidation of the molecular mechanism of neuronal differentiation.	nobiletin	27-36	Eph receptor B1	Rattus norvegicus	92-95
15585197-6	2005	This nobiletin-mediated effect was specific for SR-A and not a global effect on lipoprotein metabolism by the macrophage, as all four citrus flavonoids significantly reduce the metabolism of beta-VLDL, which is primarily taken up by macrophages via the LDL receptor.	nobiletin	5-14	low density lipoprotein receptor	Mus musculus	253-265
11743742-6	2001	Remarkably, we have also identified several compounds-valinomycin, norverapamil, reserpine, nobiletin, emetine, gallopamil, fluphenazine-that uniquely inhibit P-gp function with affinities comparable to benchmark P-gp inhibitors despite a lack of effect on CYP3A4 function at physiologically relevant concentrations.	nobiletin	92-101	phosphoglycolate phosphatase	Homo sapiens	159-163
15252145-2	2004	We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro.	nobiletin	26-35	TIMP metallopeptidase inhibitor 1	Homo sapiens	223-263
15252145-2	2004	We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro.	nobiletin	26-35	TIMP metallopeptidase inhibitor 1	Homo sapiens	265-271
15252145-2	2004	We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro.	nobiletin	37-70	TIMP metallopeptidase inhibitor 1	Homo sapiens	223-263
15252145-2	2004	We recently reported that nobiletin (5,6,7,8,3",4"-hexamethoxy flavone) exhibits novel antitumor invasive activities by suppressing the production of pro-matrix metalloproteinases (proMMPs) and augmenting the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro.	nobiletin	37-70	TIMP metallopeptidase inhibitor 1	Homo sapiens	265-271
15252145-4	2004	Nobiletin inhibited the phosphorylation of mitogen-activated protein/extracellular signal-regulated kinase (MEK) 1/2, but not the activity of Ras or the phosphorylation of Raf.	nobiletin	0-9	mitogen-activated protein kinase kinase 1	Homo sapiens	43-116
15252145-7	2004	However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells.	nobiletin	9-18	mitogen-activated protein kinase 8	Homo sapiens	63-88
15252145-7	2004	However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells.	nobiletin	9-18	mitogen-activated protein kinase 8	Homo sapiens	90-93
15252145-7	2004	However, nobiletin was found to augment the phosphorylation of c-Jun NH2-terminal kinase (JNK), a downstream signal factor of the PI3K-Akt pathway, in TPA-treated HT-1080 cells.	nobiletin	9-18	AKT serine/threonine kinase 1	Homo sapiens	135-138
15252145-10	2004	Moreover, protein kinase C (PKC) inhibitor experiments showed that PKCbetaII/epsilon were associated with the nobiletin-mediated augmentation of JNK phosphorylation.	nobiletin	110-119	mitogen-activated protein kinase 8	Homo sapiens	145-148
15252145-11	2004	Therefore, these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms: (1) the inhibition of MEK1/2 activity is involved in the suppression of MMP expression and (2) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression.	nobiletin	80-89	mitogen-activated protein kinase kinase 1	Homo sapiens	176-182
15252145-11	2004	Therefore, these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms: (1) the inhibition of MEK1/2 activity is involved in the suppression of MMP expression and (2) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression.	nobiletin	80-89	mitogen-activated protein kinase 8	Homo sapiens	295-298
15252145-11	2004	Therefore, these results introduce novel evidence that the antitumor effects of nobiletin are finely regulated by the following intracellular mechanisms: (1) the inhibition of MEK1/2 activity is involved in the suppression of MMP expression and (2) the activation of the novel PKCbetaII/epsilon-JNK pathway is associated with the augmentation of TIMP-1 expression.	nobiletin	80-89	TIMP metallopeptidase inhibitor 1	Homo sapiens	346-352
12081153-0	2002	Nobiletin as a tyrosinase inhibitor from the peel of Citrus fruit.	nobiletin	0-9	tyrosinase	Homo sapiens	15-25
12081153-1	2002	A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3",4",5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data.	nobiletin	118-150	tyrosinase	Homo sapiens	2-12
12081153-1	2002	A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3",4",5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data.	nobiletin	152-161	tyrosinase	Homo sapiens	2-12
11861377-0	2002	Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.	nobiletin	96-105	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-33
11861377-0	2002	Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.	nobiletin	96-105	TIMP metallopeptidase inhibitor 1	Homo sapiens	159-199
11861377-0	2002	Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells.	nobiletin	96-105	matrix metallopeptidase 1	Homo sapiens	244-278
11861377-6	2002	We also demonstrated that nobiletin suppressed the 12-O-tetradecanoylphorbol 13-acetate-induced binding activity of activator protein-1.	nobiletin	26-35	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	116-135
11861377-8	2002	These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin-mediated inhibition of activator protein-1 binding activity is at least partly involved in the suppression of MMP expression.	nobiletin	27-36	matrix metallopeptidase 1	Homo sapiens	117-121
11861377-8	2002	These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin-mediated inhibition of activator protein-1 binding activity is at least partly involved in the suppression of MMP expression.	nobiletin	27-36	TIMP metallopeptidase inhibitor 1	Homo sapiens	142-148
11861377-8	2002	These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin-mediated inhibition of activator protein-1 binding activity is at least partly involved in the suppression of MMP expression.	nobiletin	189-198	matrix metallopeptidase 1	Homo sapiens	117-121
11861377-8	2002	These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin-mediated inhibition of activator protein-1 binding activity is at least partly involved in the suppression of MMP expression.	nobiletin	189-198	TIMP metallopeptidase inhibitor 1	Homo sapiens	142-148
11861377-8	2002	These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin-mediated inhibition of activator protein-1 binding activity is at least partly involved in the suppression of MMP expression.	nobiletin	189-198	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-241
11861377-9	2002	Furthermore, we suggest a possible mechanism by which nobiletin may interfere in the phosphatidylinositol 3-kinase pathway, which divergently regulates the production of MMP and TIMP-1.	nobiletin	54-63	TIMP metallopeptidase inhibitor 1	Homo sapiens	178-184
15242810-4	2004	The augmented COX-2 production was transcriptionally suppressed by nobiletin.	nobiletin	67-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
15242810-6	2004	However, nobiletin was found to inhibit the release of [14C]arachidonic acid by decreasing the Ca2+ -dependent activity of cPLA2.	nobiletin	9-18	phospholipase A2 group IVA	Homo sapiens	123-128
15242810-8	2004	Therefore, these results suggest that nobiletin inhibits the UVB-induced production of PGE2 not only by suppressing the expression of COX-2 but also by decreasing the activity of cPLA2 in human keratinocytes.	nobiletin	38-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
15242810-8	2004	Therefore, these results suggest that nobiletin inhibits the UVB-induced production of PGE2 not only by suppressing the expression of COX-2 but also by decreasing the activity of cPLA2 in human keratinocytes.	nobiletin	38-47	phospholipase A2 group IVA	Homo sapiens	179-184
12787887-6	2003	Nobiletin also interfered with the lipopolysaccharide-induced production of PGE(2) and the gene expression of proinflammatory cytokines including IL-1alpha, IL-1beta, TNF-alpha and IL-6 in mouse J774A.1 macrophages.	nobiletin	0-9	interleukin 1 alpha	Mus musculus	146-155
12787887-6	2003	Nobiletin also interfered with the lipopolysaccharide-induced production of PGE(2) and the gene expression of proinflammatory cytokines including IL-1alpha, IL-1beta, TNF-alpha and IL-6 in mouse J774A.1 macrophages.	nobiletin	0-9	interleukin 1 beta	Mus musculus	157-165
12787887-6	2003	Nobiletin also interfered with the lipopolysaccharide-induced production of PGE(2) and the gene expression of proinflammatory cytokines including IL-1alpha, IL-1beta, TNF-alpha and IL-6 in mouse J774A.1 macrophages.	nobiletin	0-9	tumor necrosis factor	Mus musculus	167-176
12787887-6	2003	Nobiletin also interfered with the lipopolysaccharide-induced production of PGE(2) and the gene expression of proinflammatory cytokines including IL-1alpha, IL-1beta, TNF-alpha and IL-6 in mouse J774A.1 macrophages.	nobiletin	0-9	interleukin 6	Mus musculus	181-185
12787887-8	2003	In contrast, production of the endogenous MMP inhibitor, TIMP-1, was augmented by nobiletin.	nobiletin	82-91	TIMP metallopeptidase inhibitor 1	Homo sapiens	57-63
12787887-9	2003	These anti-inflammatory actions of nobiletin are very similar to those of anti-inflammatory steroids such as dexamethasone, and the upregulation of TIMP-1 production is a unique action of nobiletin.	nobiletin	188-197	TIMP metallopeptidase inhibitor 1	Homo sapiens	148-154
11743742-6	2001	Remarkably, we have also identified several compounds-valinomycin, norverapamil, reserpine, nobiletin, emetine, gallopamil, fluphenazine-that uniquely inhibit P-gp function with affinities comparable to benchmark P-gp inhibitors despite a lack of effect on CYP3A4 function at physiologically relevant concentrations.	nobiletin	92-101	phosphoglycolate phosphatase	Homo sapiens	213-217
11743742-6	2001	Remarkably, we have also identified several compounds-valinomycin, norverapamil, reserpine, nobiletin, emetine, gallopamil, fluphenazine-that uniquely inhibit P-gp function with affinities comparable to benchmark P-gp inhibitors despite a lack of effect on CYP3A4 function at physiologically relevant concentrations.	nobiletin	92-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	257-263
11743742-7	2001	Indeed, valinomycin inhibits P-gp with an IC(50) similar to cyclosporin A yet apparently does not affect CYP3A4 function, and emetine and nobiletin are also specific for interaction with P-gp.	nobiletin	138-147	phosphoglycolate phosphatase	Homo sapiens	187-191
11299000-7	2001	Generally, swainsonine was the least effective whereas the citrus flavonoids, particularly nobiletin, showed the greatest downregulation of secretion of the MMPs.	nobiletin	91-100	matrix metallopeptidase 2	Homo sapiens	157-161
10415793-0	1999	The citrus flavonoid nobiletin suppresses the production and gene expression of matrix metalloproteinases-9/gelatinase B in rabbit synovial cells.	nobiletin	21-30	matrix metalloproteinase-9	Oryctolagus cuniculus	108-120
10648013-0	2000	A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts.	nobiletin	20-29	matrix metalloproteinase-9	Oryctolagus cuniculus	76-102
10648013-0	2000	A citrus flavonoid, nobiletin, suppresses production and gene expression of matrix metalloproteinase 9/gelatinase B in rabbit synovial fibroblasts.	nobiletin	20-29	matrix metalloproteinase-9	Oryctolagus cuniculus	103-115
34709572-10	2022	CONCLUSION: Both nobiletin doses showed protective effects against diabetes-induced testicular injury by reducing oxidative stress, hyperglycemia, inflammation, and caspase-3 and upregulating the hypophysis-gonadal axis and AR.	nobiletin	17-26	caspase 3	Rattus norvegicus	165-174
34262419-10	2021	Results: The network analysis revealed that the key active components of chenpi (nobiletin, naringenin, hesperetin) regulate five core targets (AKT1, TP53, IL6, VEGFA, MMP9).	nobiletin	81-90	thymoma viral proto-oncogene 1	Mus musculus	144-148
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	nobiletin	108-117	interleukin 6	Homo sapiens	219-222
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	nobiletin	108-117	prostaglandin-endoperoxide synthase 2	Homo sapiens	224-229
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	nobiletin	108-117	mitogen-activated protein kinase 1	Homo sapiens	231-236
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	nobiletin	108-117	mitogen-activated protein kinase 3	Homo sapiens	238-243
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	nobiletin	108-117	calcitonin related polypeptide alpha	Homo sapiens	249-254
34173673-0	2021	Nobiletin alleviates the hypoxia/reoxygenation-induced damage in myocardial cells by modulating the miR-433/SIRT1 axis.	nobiletin	0-9	microRNA 433	Rattus norvegicus	100-107
34173673-0	2021	Nobiletin alleviates the hypoxia/reoxygenation-induced damage in myocardial cells by modulating the miR-433/SIRT1 axis.	nobiletin	0-9	sirtuin 1	Rattus norvegicus	108-113
34650395-15	2021	Results: Hypoxia treatment resulted in a decreased cell viability and cell membrane integrity in JEG-3 and BeWo cell lines, and an increased expression of HIF1alpha, cell cycle arrest in the G1 phase, and massive cell apoptosis, which were alleviated after NOB treatment.	nobiletin	257-260	hypoxia inducible factor 1 subunit alpha	Homo sapiens	155-164
34262419-10	2021	Results: The network analysis revealed that the key active components of chenpi (nobiletin, naringenin, hesperetin) regulate five core targets (AKT1, TP53, IL6, VEGFA, MMP9).	nobiletin	81-90	transformation related protein 53	Mus musculus	150-154
34262419-10	2021	Results: The network analysis revealed that the key active components of chenpi (nobiletin, naringenin, hesperetin) regulate five core targets (AKT1, TP53, IL6, VEGFA, MMP9).	nobiletin	81-90	interleukin 6	Mus musculus	156-159
34262419-10	2021	Results: The network analysis revealed that the key active components of chenpi (nobiletin, naringenin, hesperetin) regulate five core targets (AKT1, TP53, IL6, VEGFA, MMP9).	nobiletin	81-90	vascular endothelial growth factor A	Mus musculus	161-166
34262419-10	2021	Results: The network analysis revealed that the key active components of chenpi (nobiletin, naringenin, hesperetin) regulate five core targets (AKT1, TP53, IL6, VEGFA, MMP9).	nobiletin	81-90	matrix metallopeptidase 9	Mus musculus	168-172
34066937-6	2021	Moreover, we revealed that nobiletin treatment could suppress the activation of the NF-kappaB, MAPKs, and Akt pathways.	nobiletin	27-36	nuclear factor kappa B subunit 1	Homo sapiens	84-93
34066937-6	2021	Moreover, we revealed that nobiletin treatment could suppress the activation of the NF-kappaB, MAPKs, and Akt pathways.	nobiletin	27-36	AKT serine/threonine kinase 1	Homo sapiens	106-109
35440077-0	2022	ROR activation by Nobiletin enhances antitumor efficacy via suppression of IkappaB/NF-kappaB signaling in triple-negative breast cancer.	nobiletin	18-27	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	0-3
35344715-12	2022	The combination of nobiletin and doxorubicin synergistically killed HEK293-SOX5 cells in isobologram analyses, implying attractive new treatment options.	nobiletin	19-28	SRY-box transcription factor 5	Homo sapiens	75-79
35440077-0	2022	ROR activation by Nobiletin enhances antitumor efficacy via suppression of IkappaB/NF-kappaB signaling in triple-negative breast cancer.	nobiletin	18-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
33660406-9	2021	Together, our study suggested that JNK inhibition plays an important role in Nobiletin-induced antiapoptotic effect in myocardial infarction, and medium-dose Nobiletin demonstrated the strongest effect in vivo.	nobiletin	77-86	mitogen-activated protein kinase 8	Rattus norvegicus	35-38
35350242-9	2022	Furthermore, knockdown of GSK3beta significantly reduced nobiletin-induced ferroptosis and upregulated the Keap1/Nrf2/HO-1 signalling pathway, while the opposite was observed in cells overexpressing GSK3beta.	nobiletin	57-66	glycogen synthase kinase 3 alpha	Homo sapiens	26-34
35350242-9	2022	Furthermore, knockdown of GSK3beta significantly reduced nobiletin-induced ferroptosis and upregulated the Keap1/Nrf2/HO-1 signalling pathway, while the opposite was observed in cells overexpressing GSK3beta.	nobiletin	57-66	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117
35350242-9	2022	Furthermore, knockdown of GSK3beta significantly reduced nobiletin-induced ferroptosis and upregulated the Keap1/Nrf2/HO-1 signalling pathway, while the opposite was observed in cells overexpressing GSK3beta.	nobiletin	57-66	heme oxygenase 1	Homo sapiens	118-122
35350242-9	2022	Furthermore, knockdown of GSK3beta significantly reduced nobiletin-induced ferroptosis and upregulated the Keap1/Nrf2/HO-1 signalling pathway, while the opposite was observed in cells overexpressing GSK3beta.	nobiletin	57-66	glycogen synthase kinase 3 alpha	Homo sapiens	199-207
33439200-9	2021	Mechanistically, we found that nobiletin treatment leads to activation of the IL-6/STAT3/FOXO3a signal pathway through the down-regulation of IL-6 and STAT3 phosphorylation and the upregulation of FOXO3a phosphorylation in the cell nucleus, which is responsible for induction of macrophage autophagy.	nobiletin	31-40	interleukin 6	Mus musculus	78-82
33439200-9	2021	Mechanistically, we found that nobiletin treatment leads to activation of the IL-6/STAT3/FOXO3a signal pathway through the down-regulation of IL-6 and STAT3 phosphorylation and the upregulation of FOXO3a phosphorylation in the cell nucleus, which is responsible for induction of macrophage autophagy.	nobiletin	31-40	forkhead box O3	Mus musculus	89-95
33439200-9	2021	Mechanistically, we found that nobiletin treatment leads to activation of the IL-6/STAT3/FOXO3a signal pathway through the down-regulation of IL-6 and STAT3 phosphorylation and the upregulation of FOXO3a phosphorylation in the cell nucleus, which is responsible for induction of macrophage autophagy.	nobiletin	31-40	interleukin 6	Mus musculus	142-146
33439200-9	2021	Mechanistically, we found that nobiletin treatment leads to activation of the IL-6/STAT3/FOXO3a signal pathway through the down-regulation of IL-6 and STAT3 phosphorylation and the upregulation of FOXO3a phosphorylation in the cell nucleus, which is responsible for induction of macrophage autophagy.	nobiletin	31-40	forkhead box O3	Mus musculus	197-203
32703431-3	2020	Additionally, we found that NBT augments the activity of the endogenous peptide ligand urocortin 2 (Ucn2) in a concentration-dependent manner.	nobiletin	28-31	urocortin 2	Mus musculus	87-98
32002792-0	2020	Nobiletin Regulates ROS/ADMA/DDAHII/eNOS/NO Pathway and Alleviates Vascular Endothelium Injury by Iron Overload.	nobiletin	0-9	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	29-35
32002792-0	2020	Nobiletin Regulates ROS/ADMA/DDAHII/eNOS/NO Pathway and Alleviates Vascular Endothelium Injury by Iron Overload.	nobiletin	0-9	nitric oxide synthase 3	Homo sapiens	36-40
32002792-4	2020	In this study, we have identified the protective effects of Nob, and its underlying molecular mechanism in human umbilical vein endothelial cells (HUVECs) suffered from iron overload via ROS/ADMA/DDAHII/eNOS/NO pathway.	nobiletin	60-63	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	196-202
32002792-4	2020	In this study, we have identified the protective effects of Nob, and its underlying molecular mechanism in human umbilical vein endothelial cells (HUVECs) suffered from iron overload via ROS/ADMA/DDAHII/eNOS/NO pathway.	nobiletin	60-63	nitric oxide synthase 3	Homo sapiens	203-207
32002792-6	2020	Besides, Nob could upregulate DDAHII expression and activity, promote eNOS phosphorylation to produce more NO, reduce ADMA content, and therefore increase superoxide dismutase, catalase, and glutathione peroxidase activities, and decrease malondialdehyde level and ROS generation.	nobiletin	9-12	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	30-36
32002792-6	2020	Besides, Nob could upregulate DDAHII expression and activity, promote eNOS phosphorylation to produce more NO, reduce ADMA content, and therefore increase superoxide dismutase, catalase, and glutathione peroxidase activities, and decrease malondialdehyde level and ROS generation.	nobiletin	9-12	nitric oxide synthase 3	Homo sapiens	70-74
32002792-6	2020	Besides, Nob could upregulate DDAHII expression and activity, promote eNOS phosphorylation to produce more NO, reduce ADMA content, and therefore increase superoxide dismutase, catalase, and glutathione peroxidase activities, and decrease malondialdehyde level and ROS generation.	nobiletin	9-12	catalase	Homo sapiens	177-185
32002792-9	2020	The addition of pAD/DDAHII-shRNA adenovirus reversed the above effects of Nob.	nobiletin	74-77	peptidyl arginine deiminase 4	Homo sapiens	16-19
32002792-9	2020	The addition of pAD/DDAHII-shRNA adenovirus reversed the above effects of Nob.	nobiletin	74-77	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	20-26
32002792-10	2020	These data suggested that the protective mechanism of Nob was to inhibit ROS burst, upregulate DDAHII expression and activity, promote eNOS phosphorylation, produce NO, reduce ADMA content, and ultimately alleviate iron overload damage in vascular endothelium.	nobiletin	54-57	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	95-101
32002792-10	2020	These data suggested that the protective mechanism of Nob was to inhibit ROS burst, upregulate DDAHII expression and activity, promote eNOS phosphorylation, produce NO, reduce ADMA content, and ultimately alleviate iron overload damage in vascular endothelium.	nobiletin	54-57	nitric oxide synthase 3	Homo sapiens	135-139
33138135-10	2020	Apigenin and nobiletin were identified in TCF, while nobiletin, ursolic acid, and lupeol were the main compounds identified in ACF.	nobiletin	13-22	hepatocyte nuclear factor 4 alpha	Homo sapiens	42-45
32703431-3	2020	Additionally, we found that NBT augments the activity of the endogenous peptide ligand urocortin 2 (Ucn2) in a concentration-dependent manner.	nobiletin	28-31	urocortin 2	Mus musculus	100-104
32703431-4	2020	Computational simulation of CRFR2beta confirmed that transmembrane domains (TMs) 1 and 2 are important for the synergistic activity of NBT and also identified important amino acids in these domains.	nobiletin	135-138	corticotropin releasing hormone receptor 2	Mus musculus	28-37
32703431-4	2020	Computational simulation of CRFR2beta confirmed that transmembrane domains (TMs) 1 and 2 are important for the synergistic activity of NBT and also identified important amino acids in these domains.	nobiletin	135-138	tropomyosin 1, alpha	Mus musculus	53-88
32703431-6	2020	These observations demonstrate that NBT can activate CRFR2beta and amplify the agonistic activity of Ucn2 and that such food-derived molecules have the potential to enhance endogenous G protein-coupled receptor ligand activities and contribute to the maintenance of skeletal muscle mass and function.	nobiletin	36-39	corticotropin releasing hormone receptor 2	Mus musculus	53-62
32703431-6	2020	These observations demonstrate that NBT can activate CRFR2beta and amplify the agonistic activity of Ucn2 and that such food-derived molecules have the potential to enhance endogenous G protein-coupled receptor ligand activities and contribute to the maintenance of skeletal muscle mass and function.	nobiletin	36-39	urocortin 2	Mus musculus	101-105
31978425-0	2020	Nobiletin suppresses IL-21/IL-21 receptor-mediated inflammatory response in MH7A fibroblast-like synoviocytes (FLS): An implication in rheumatoid arthritis.	nobiletin	0-9	interleukin 21	Homo sapiens	21-26
31978425-0	2020	Nobiletin suppresses IL-21/IL-21 receptor-mediated inflammatory response in MH7A fibroblast-like synoviocytes (FLS): An implication in rheumatoid arthritis.	nobiletin	0-9	interleukin 21 receptor	Homo sapiens	27-41
31978425-4	2020	In the present study, we investigated the impact of nobiletin in mediating the effects of interleukin-21 (IL-21) in MH7A fibroblast-like synoviocytes (FLS), the main cell type found in the articular synovium.	nobiletin	52-61	interleukin 21	Homo sapiens	90-104
31978425-4	2020	In the present study, we investigated the impact of nobiletin in mediating the effects of interleukin-21 (IL-21) in MH7A fibroblast-like synoviocytes (FLS), the main cell type found in the articular synovium.	nobiletin	52-61	interleukin 21	Homo sapiens	106-111
31978425-5	2020	Firstly, we demonstrate that nobiletin (25 muM and 50 muM) reduced the expression of the IL-21 receptor by 29% and 51%, respectively, in FLS.	nobiletin	29-38	latexin	Homo sapiens	43-46
31978425-5	2020	Firstly, we demonstrate that nobiletin (25 muM and 50 muM) reduced the expression of the IL-21 receptor by 29% and 51%, respectively, in FLS.	nobiletin	29-38	latexin	Homo sapiens	54-57
31978425-5	2020	Firstly, we demonstrate that nobiletin (25 muM and 50 muM) reduced the expression of the IL-21 receptor by 29% and 51%, respectively, in FLS.	nobiletin	29-38	interleukin 21 receptor	Homo sapiens	89-103
31632564-9	2019	Apoptosis induced by cerebral I/R was also decreased by NOB administration via upregulating Bcl-2 and downregulating Bax and caspase3.	nobiletin	56-59	BCL2, apoptosis regulator	Rattus norvegicus	92-97
32062137-0	2020	Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages.	nobiletin	24-33	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	45-50
32062137-4	2020	In this study, regulation of HDL biogenesis by NOB was investigated modulating ABCA1 and ABCG1 expression.	nobiletin	47-50	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	79-84
32062137-4	2020	In this study, regulation of HDL biogenesis by NOB was investigated modulating ABCA1 and ABCG1 expression.	nobiletin	47-50	ATP binding cassette subfamily G member 1	Mus musculus	89-94
32062137-5	2020	METHODS AND RESULTS: Regulation of ABCA1/G1 by NOB was investigated in mouse macrophages J774.1.	nobiletin	47-50	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	35-40
32062137-6	2020	NOB increased mRNA and protein levels of ABCA1/G1, and cell cholesterol release by these factors.	nobiletin	0-3	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	41-46
32062137-8	2020	The increase in ABCA1/G1 mRNA levels by NOB was suppressed by antagonists of PPARgamma and LXRalpha.	nobiletin	40-43	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	16-21
32062137-8	2020	The increase in ABCA1/G1 mRNA levels by NOB was suppressed by antagonists of PPARgamma and LXRalpha.	nobiletin	40-43	peroxisome proliferator activated receptor gamma	Mus musculus	77-86
32062137-8	2020	The increase in ABCA1/G1 mRNA levels by NOB was suppressed by antagonists of PPARgamma and LXRalpha.	nobiletin	40-43	nuclear receptor subfamily 1, group H, member 3	Mus musculus	91-99
32062137-9	2020	The increase in PPARgamma mRNA levels by NOB was suppressed by an LXRalpha antagonist, and the increase in LXRalpha mRNA levels was suppressed by a PPARgamma antagonist.	nobiletin	41-44	peroxisome proliferator activated receptor gamma	Mus musculus	16-25
32062137-9	2020	The increase in PPARgamma mRNA levels by NOB was suppressed by an LXRalpha antagonist, and the increase in LXRalpha mRNA levels was suppressed by a PPARgamma antagonist.	nobiletin	41-44	nuclear receptor subfamily 1, group H, member 3	Mus musculus	66-74
32062137-10	2020	NOB increased CD36 mRNA and this was suppressed by an LXRalpha antagonist.	nobiletin	0-3	nuclear receptor subfamily 1, group H, member 3	Mus musculus	54-62
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	0-3	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	57-62
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	0-3	nuclear receptor subfamily 1, group H, member 3	Mus musculus	67-75
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	0-3	peroxisome proliferator activated receptor gamma	Mus musculus	80-89
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	0-3	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	106-111
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	133-136	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	57-62
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	133-136	nuclear receptor subfamily 1, group H, member 3	Mus musculus	67-75
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	133-136	peroxisome proliferator activated receptor gamma	Mus musculus	80-89
32062137-13	2020	NOB stimulated AMPK phosphorylation, and the increase in ABCA1/G1, LXRalpha and PPARgamma mRNA levels and ABCA1/G1 protein levels by NOB was reversed by an AMPK inhibitor.	nobiletin	133-136	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	106-111
32062137-15	2020	CONCLUSIONS: NOB activates AMPK and subsequently LXRalpha to promote the expression of ABCA1 and ABCG1, and an LXRalpha - PPARgamma loop pathway amplifies these signals.	nobiletin	13-16	nuclear receptor subfamily 1, group H, member 3	Mus musculus	49-57
32062137-15	2020	CONCLUSIONS: NOB activates AMPK and subsequently LXRalpha to promote the expression of ABCA1 and ABCG1, and an LXRalpha - PPARgamma loop pathway amplifies these signals.	nobiletin	13-16	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	87-92
32062137-15	2020	CONCLUSIONS: NOB activates AMPK and subsequently LXRalpha to promote the expression of ABCA1 and ABCG1, and an LXRalpha - PPARgamma loop pathway amplifies these signals.	nobiletin	13-16	ATP binding cassette subfamily G member 1	Mus musculus	97-102
31955565-5	2020	Our results showed that nobiletin could significantly inhibit cell proliferation, induce DNA damage, and also lead to apoptosis by increasing the cleaved poly (ADP-ribose) polymerase (PARP) level of human ovarian cancer cells (HOCCs) in a dose-dependent manner.	nobiletin	24-33	poly(ADP-ribose) polymerase 1	Homo sapiens	154-182
31955565-5	2020	Our results showed that nobiletin could significantly inhibit cell proliferation, induce DNA damage, and also lead to apoptosis by increasing the cleaved poly (ADP-ribose) polymerase (PARP) level of human ovarian cancer cells (HOCCs) in a dose-dependent manner.	nobiletin	24-33	poly(ADP-ribose) polymerase 1	Homo sapiens	184-188
31955565-6	2020	Moreover, we revealed that nobiletin decreased mitochondrial membrane potential and induced reactive oxygen species (ROS) generation and autophagy of HOCCs, contributing to gasdermin D-/gasdermin E-mediated pyroptosis.	nobiletin	27-36	gasdermin D	Homo sapiens	173-184
32047858-3	2020	We found that naringenin and nobiletin strongly inhibited URAT1, and may therefore serve as an anti-hyperuricemic food ingredient that can reduce the risk of urate-related diseases.	nobiletin	29-38	solute carrier family 22 member 12	Homo sapiens	58-63
31676069-0	2020	Nobiletin and related polymethoxylated flavones bind to and inhibit the nuclear export factor Exportin-1 in NK leukemia cell line KHYG-1.	nobiletin	0-9	exportin 1	Homo sapiens	94-104
31676069-2	2020	We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma).	nobiletin	45-54	granzyme B	Homo sapiens	188-198
31676069-2	2020	We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma).	nobiletin	45-54	granzyme B	Homo sapiens	200-203
31676069-2	2020	We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma).	nobiletin	45-54	interferon gamma	Homo sapiens	240-249
31676069-5	2020	Using affinity purification and mass spectrometry, we identified that 3"-hydroxy-4",5,6,7-tetramethoxyflavone (TMF) binds to the nuclear export factors Exportin-1 and -2 (XPO1 and XPO2) as TMF-binding proteins and demonstrated that nobiletin competes with TMF for XPO1 binding, suggesting that nobiletin also binds to XPO1.	nobiletin	232-241	exportin 1	Homo sapiens	152-169
31676069-5	2020	Using affinity purification and mass spectrometry, we identified that 3"-hydroxy-4",5,6,7-tetramethoxyflavone (TMF) binds to the nuclear export factors Exportin-1 and -2 (XPO1 and XPO2) as TMF-binding proteins and demonstrated that nobiletin competes with TMF for XPO1 binding, suggesting that nobiletin also binds to XPO1.	nobiletin	232-241	exportin 1	Homo sapiens	171-175
31676069-5	2020	Using affinity purification and mass spectrometry, we identified that 3"-hydroxy-4",5,6,7-tetramethoxyflavone (TMF) binds to the nuclear export factors Exportin-1 and -2 (XPO1 and XPO2) as TMF-binding proteins and demonstrated that nobiletin competes with TMF for XPO1 binding, suggesting that nobiletin also binds to XPO1.	nobiletin	294-303	exportin 1	Homo sapiens	152-169
31676069-5	2020	Using affinity purification and mass spectrometry, we identified that 3"-hydroxy-4",5,6,7-tetramethoxyflavone (TMF) binds to the nuclear export factors Exportin-1 and -2 (XPO1 and XPO2) as TMF-binding proteins and demonstrated that nobiletin competes with TMF for XPO1 binding, suggesting that nobiletin also binds to XPO1.	nobiletin	294-303	exportin 1	Homo sapiens	171-175
31676069-7	2020	Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression.	nobiletin	22-31	nuclear factor kappa B subunit 1	Homo sapiens	82-91
31676069-7	2020	Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression.	nobiletin	22-31	granzyme B	Homo sapiens	130-133
31676069-7	2020	Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression.	nobiletin	22-31	interferon gamma	Homo sapiens	138-147
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	77-82
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	84-92
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Glutathione S-transferase 4	Caenorhabditis elegans	94-99
31806568-8	2020	The NOB-treated group mitigated oxidative stress via augmented SOD, reduced MDA, and enhanced vascular endothelial growth factor (VEGF) expression.	nobiletin	4-7	vascular endothelial growth factor A	Rattus norvegicus	94-128
31806568-8	2020	The NOB-treated group mitigated oxidative stress via augmented SOD, reduced MDA, and enhanced vascular endothelial growth factor (VEGF) expression.	nobiletin	4-7	vascular endothelial growth factor A	Rattus norvegicus	130-134
31514996-3	2019	Sudachitin activated p38MAPK and inhibited ERK1/2, whereas another polymethoxyflavone, nobiletin (5,6,7,8,3",4"-hexamethoxyflavone), activated ERK1/2.	nobiletin	98-130	mitogen-activated protein kinase 3	Homo sapiens	143-149
31432129-6	2019	However, the daily administration of CAE and nobiletin reduced the spatial learning deficits and increased the AchE activity in the cortex and hippocampus.	nobiletin	45-54	acetylcholinesterase	Mus musculus	111-115
31432129-7	2019	Furthermore, CAE and nobiletin significantly downregulated the Bax and cleaved caspase-3 protein expression and upregulated the Bcl-2 and Bcl-2/Bax expression in the cortex and hippocampus of Abeta-treated mice.	nobiletin	21-30	BCL2-associated X protein	Mus musculus	63-66
31432129-7	2019	Furthermore, CAE and nobiletin significantly downregulated the Bax and cleaved caspase-3 protein expression and upregulated the Bcl-2 and Bcl-2/Bax expression in the cortex and hippocampus of Abeta-treated mice.	nobiletin	21-30	B cell leukemia/lymphoma 2	Mus musculus	128-133
31432129-7	2019	Furthermore, CAE and nobiletin significantly downregulated the Bax and cleaved caspase-3 protein expression and upregulated the Bcl-2 and Bcl-2/Bax expression in the cortex and hippocampus of Abeta-treated mice.	nobiletin	21-30	B cell leukemia/lymphoma 2	Mus musculus	138-143
31432129-7	2019	Furthermore, CAE and nobiletin significantly downregulated the Bax and cleaved caspase-3 protein expression and upregulated the Bcl-2 and Bcl-2/Bax expression in the cortex and hippocampus of Abeta-treated mice.	nobiletin	21-30	BCL2-associated X protein	Mus musculus	144-147
31432129-8	2019	These results suggest that CAE and nobiletin exert a neuroprotective effect by regulating anti-apoptotic mechanisms, including reduced AchE activity in the cortex and hippocampus of the cognitive deficit mouse model.	nobiletin	35-44	acetylcholinesterase	Mus musculus	135-139
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	interleukin 21	Homo sapiens	75-80
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	interleukin 6	Homo sapiens	183-196
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	interleukin 6	Homo sapiens	198-202
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	tumor necrosis factor	Homo sapiens	205-232
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	tumor necrosis factor	Homo sapiens	234-243
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	high mobility group box 1	Homo sapiens	250-275
31978425-6	2020	Additionally, our findings demonstrate that nobiletin potently ameliorated IL-21-induced increased production of reactive oxygen species and 4-hydroxynonenal, increased expression of interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-mobility group box 1 (HMGB1), and decreased mitochondrial membrane potential.	nobiletin	44-53	high mobility group box 1	Homo sapiens	277-282
31978425-7	2020	We also demonstrate the ability of nobiletin to attenuate IL-21-induced expression of matrix metalloproteinases 3 and 13 (MMP-3, MMP-13), key degradative enzymes involved in RA-associated cartilage destruction.	nobiletin	35-44	interleukin 21	Homo sapiens	58-63
31978425-7	2020	We also demonstrate the ability of nobiletin to attenuate IL-21-induced expression of matrix metalloproteinases 3 and 13 (MMP-3, MMP-13), key degradative enzymes involved in RA-associated cartilage destruction.	nobiletin	35-44	matrix metallopeptidase 13	Homo sapiens	86-120
31978425-7	2020	We also demonstrate the ability of nobiletin to attenuate IL-21-induced expression of matrix metalloproteinases 3 and 13 (MMP-3, MMP-13), key degradative enzymes involved in RA-associated cartilage destruction.	nobiletin	35-44	matrix metallopeptidase 3	Homo sapiens	122-127
31978425-7	2020	We also demonstrate the ability of nobiletin to attenuate IL-21-induced expression of matrix metalloproteinases 3 and 13 (MMP-3, MMP-13), key degradative enzymes involved in RA-associated cartilage destruction.	nobiletin	35-44	matrix metallopeptidase 13	Homo sapiens	129-135
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	37-46	Janus kinase 1	Homo sapiens	72-76
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	37-46	signal transducer and activator of transcription 3	Homo sapiens	77-82
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	37-46	Janus kinase 1	Homo sapiens	155-159
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	37-46	signal transducer and activator of transcription 3	Homo sapiens	164-169
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	95-104	Janus kinase 1	Homo sapiens	72-76
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	95-104	signal transducer and activator of transcription 3	Homo sapiens	77-82
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	95-104	Janus kinase 1	Homo sapiens	155-159
31978425-8	2020	Finally, we show that the effects of nobiletin are mediated through the JAK1/STAT3 pathway, as nobiletin significantly reduced the phosphorylation of both JAK1 and STAT3.	nobiletin	95-104	signal transducer and activator of transcription 3	Homo sapiens	164-169
31978425-9	2020	Taken together, our findings indicate that nobiletin may offer a safe and effective treatment against the development and progression of RA induced by the expression of IL-21 and its receptor.	nobiletin	43-52	interleukin 21	Homo sapiens	169-174
32048561-0	2020	Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells.	nobiletin	29-38	toll like receptor 4	Homo sapiens	42-46
32048561-0	2020	Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells.	nobiletin	29-38	TIR domain containing adaptor molecule 1	Homo sapiens	47-51
32048561-0	2020	Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells.	nobiletin	29-38	interferon regulatory factor 3	Homo sapiens	52-56
32048561-0	2020	Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells.	nobiletin	29-38	toll like receptor 9	Homo sapiens	61-65
32048561-0	2020	Anti-inflammatory effects of nobiletin on TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in prostate cancer cells.	nobiletin	29-38	interferon regulatory factor 7	Homo sapiens	66-70
32048561-4	2020	However, there is no study in the literature investigating the potential anti-inflammatory effects of NOB on the TLR signaling pathways in cancer.	nobiletin	102-105	toll like receptor 4	Homo sapiens	113-116
32048561-5	2020	Therefore, we aimed to explore the potential anti-inflammatory effects of NOB on the TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in different types of PCa cell lines, for the first time.Material and methods: In the current study, the cytotoxic effect of NOB PC-3 (hormone-independent and metastatic) and LNCaP cells (hormone-dependent) was evaluated by WST-1 assay.	nobiletin	74-77	toll like receptor 4	Homo sapiens	85-89
32048561-5	2020	Therefore, we aimed to explore the potential anti-inflammatory effects of NOB on the TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in different types of PCa cell lines, for the first time.Material and methods: In the current study, the cytotoxic effect of NOB PC-3 (hormone-independent and metastatic) and LNCaP cells (hormone-dependent) was evaluated by WST-1 assay.	nobiletin	74-77	TIR domain containing adaptor molecule 1	Homo sapiens	90-94
32048561-5	2020	Therefore, we aimed to explore the potential anti-inflammatory effects of NOB on the TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in different types of PCa cell lines, for the first time.Material and methods: In the current study, the cytotoxic effect of NOB PC-3 (hormone-independent and metastatic) and LNCaP cells (hormone-dependent) was evaluated by WST-1 assay.	nobiletin	74-77	interferon regulatory factor 3	Homo sapiens	95-99
32048561-5	2020	Therefore, we aimed to explore the potential anti-inflammatory effects of NOB on the TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in different types of PCa cell lines, for the first time.Material and methods: In the current study, the cytotoxic effect of NOB PC-3 (hormone-independent and metastatic) and LNCaP cells (hormone-dependent) was evaluated by WST-1 assay.	nobiletin	74-77	toll like receptor 9	Homo sapiens	104-108
32048561-5	2020	Therefore, we aimed to explore the potential anti-inflammatory effects of NOB on the TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways in different types of PCa cell lines, for the first time.Material and methods: In the current study, the cytotoxic effect of NOB PC-3 (hormone-independent and metastatic) and LNCaP cells (hormone-dependent) was evaluated by WST-1 assay.	nobiletin	74-77	interferon regulatory factor 7	Homo sapiens	109-113
32048561-6	2020	Furthermore, the inhibitory effects of NOB on TLR4/TRIF/IRF3 and TLR9/IRF7signaling pathway were determined by RT-PCR, western blotting and ELISA analysis.Results: NOB demonstrated an inhibitory effect on PCa cell growth and LNCaP cells were more sensitive to NOB than PC-3 cells due to androjen receptor status.	nobiletin	39-42	toll like receptor 4	Homo sapiens	46-50
32048561-6	2020	Furthermore, the inhibitory effects of NOB on TLR4/TRIF/IRF3 and TLR9/IRF7signaling pathway were determined by RT-PCR, western blotting and ELISA analysis.Results: NOB demonstrated an inhibitory effect on PCa cell growth and LNCaP cells were more sensitive to NOB than PC-3 cells due to androjen receptor status.	nobiletin	39-42	TIR domain containing adaptor molecule 1	Homo sapiens	51-55
32048561-6	2020	Furthermore, the inhibitory effects of NOB on TLR4/TRIF/IRF3 and TLR9/IRF7signaling pathway were determined by RT-PCR, western blotting and ELISA analysis.Results: NOB demonstrated an inhibitory effect on PCa cell growth and LNCaP cells were more sensitive to NOB than PC-3 cells due to androjen receptor status.	nobiletin	39-42	interferon regulatory factor 3	Homo sapiens	56-60
32048561-6	2020	Furthermore, the inhibitory effects of NOB on TLR4/TRIF/IRF3 and TLR9/IRF7signaling pathway were determined by RT-PCR, western blotting and ELISA analysis.Results: NOB demonstrated an inhibitory effect on PCa cell growth and LNCaP cells were more sensitive to NOB than PC-3 cells due to androjen receptor status.	nobiletin	39-42	toll like receptor 9	Homo sapiens	65-69
32048561-6	2020	Furthermore, the inhibitory effects of NOB on TLR4/TRIF/IRF3 and TLR9/IRF7signaling pathway were determined by RT-PCR, western blotting and ELISA analysis.Results: NOB demonstrated an inhibitory effect on PCa cell growth and LNCaP cells were more sensitive to NOB than PC-3 cells due to androjen receptor status.	nobiletin	39-42	interferon regulatory factor 7	Homo sapiens	70-74
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	toll like receptor 4	Homo sapiens	38-42
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	TIR domain containing adaptor molecule 1	Homo sapiens	43-47
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	interferon regulatory factor 3	Homo sapiens	48-52
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	toll like receptor 9	Homo sapiens	57-61
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	interferon regulatory factor 7	Homo sapiens	62-66
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	interferon alpha 1	Homo sapiens	195-204
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	interferon alpha 1	Homo sapiens	209-217
32048561-7	2020	Furthermore, NOB alone could suppress TLR4/TRIF/IRF3 and TLR9/IRF7 signaling pathways through the downregulation of their associated pathways (mRNA and related protein levels) and the release of IFN-alpha and IFN-beta compared to LPS or CpG-ODN stimulated PCa cells.Conclusions: NOB potentially inhibited TLR4 and TL9-dependent signaling pathway in PCa cells.	nobiletin	13-16	toll like receptor 4	Homo sapiens	305-309
32129440-6	2020	Mechanistically, nobiletin significantly inhibited Akt and Erk activation in placenta, and NF-kappaB activation in VAT.	nobiletin	17-26	AKT serine/threonine kinase 1	Homo sapiens	51-54
32129440-6	2020	Mechanistically, nobiletin significantly inhibited Akt and Erk activation in placenta, and NF-kappaB activation in VAT.	nobiletin	17-26	mitogen-activated protein kinase 1	Homo sapiens	59-62
31705353-0	2020	Nobiletin Protects from Renal Ischemia-Reperfusion Injury in Rats by Suppressing Inflammatory Cytokines and Regulating iNOS-eNOS Expressions.	nobiletin	0-9	nitric oxide synthase 2	Rattus norvegicus	119-123
31705353-2	2020	In this study, we investigated whether nobiletin had protective effects on inflammatory parameters, oxidative damage, iNOS-eNOS expressions, and histopathological structure of renal tissue in rats with renal ischemia-reperfusion injury.	nobiletin	39-48	nitric oxide synthase 2	Rattus norvegicus	118-122
31705353-8	2020	In histopathological analyses, destruction and increased iNOS-eNOS expressions in the IR group showed a significant decrease in group 4 (Nobiletin + IR).	nobiletin	137-146	nitric oxide synthase 2	Rattus norvegicus	57-61
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	101-106
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	108-113
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	119-126
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	278-302
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	Heat shock transcription factor hsf-1	Caenorhabditis elegans	304-343
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	43-46	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	349-365
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	77-82
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	84-92
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Glutathione S-transferase 4	Caenorhabditis elegans	94-99
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	101-106
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Dual specificity mitogen-activated protein kinase kinase sek-1	Caenorhabditis elegans	108-113
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1	Caenorhabditis elegans	119-126
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	278-302
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	Heat shock transcription factor hsf-1	Caenorhabditis elegans	304-343
31948007-6	2020	Furthermore, gene expression revealed that NOB upregulated the expression of sod-3, hsp-16.2, gst-4, skn-1, sek-1, and sir-2.1, which was suggested that anti-aging activity of NOB was mediated most likely by activation of the target genes of the transcription factors including dauer formation (DAF)-16, heat-shock transcription factor (HSF)-1, and skinhead (SKN)-1.	nobiletin	176-179	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	349-365
31287730-9	2020	At 100 muM, nobiletin reduced ATC cell viability as efficiently as conventional drugs, such as cisplatin, while being less toxic to normal thyroid cells.	nobiletin	12-21	latexin	Homo sapiens	7-10
31632564-9	2019	Apoptosis induced by cerebral I/R was also decreased by NOB administration via upregulating Bcl-2 and downregulating Bax and caspase3.	nobiletin	56-59	BCL2 associated X, apoptosis regulator	Rattus norvegicus	117-120
31632564-9	2019	Apoptosis induced by cerebral I/R was also decreased by NOB administration via upregulating Bcl-2 and downregulating Bax and caspase3.	nobiletin	56-59	caspase 3	Rattus norvegicus	125-133
31632564-10	2019	The levels of pro-inflammatory mediators TNF-alpha, IL-6 were reduced and anti-inflammatory cytokine IL-10 was increased by NOB treatment in MCAO rats.	nobiletin	124-127	interleukin 10	Rattus norvegicus	101-106
31398899-0	2019	Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells.	nobiletin	105-114	AKT serine/threonine kinase 1	Homo sapiens	85-88
31398899-0	2019	Involvement of Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and the PI3K/AKT/mTOR Pathway in Nobiletin-Induced Apoptosis of Human Bladder Cancer Cells.	nobiletin	105-114	mechanistic target of rapamycin kinase	Homo sapiens	89-93
31398899-7	2019	NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2alpha/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway.	nobiletin	0-3	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	91-95
31398899-7	2019	NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2alpha/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway.	nobiletin	0-3	activating transcription factor 4	Homo sapiens	106-110
31398899-7	2019	NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2alpha/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway.	nobiletin	0-3	DNA damage inducible transcript 3	Homo sapiens	111-115
31398899-7	2019	NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2alpha/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway.	nobiletin	0-3	AKT serine/threonine kinase 1	Homo sapiens	153-156
31398899-7	2019	NOB-induced apoptosis was also mediated by regulating endoplasmic reticulum stress via the PERK/elF2alpha/ATF4/CHOP pathway, and downregulating the PI3K/AKT/mTOR pathway.	nobiletin	0-3	mechanistic target of rapamycin kinase	Homo sapiens	157-161
31082728-0	2019	Nobiletin ameliorates myocardial ischemia and reperfusion injury by attenuating endoplasmic reticulum stress-associated apoptosis through regulation of the PI3K/AKT signal pathway.	nobiletin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	161-164
31082728-9	2019	Importantly, pre-treatment with nobiletin significantly downregulated the myocardial mRNA and protein levels of ERS-related signal molecules, including GRP78, CHOP and caspase-12, but upregulated the levels of p-PI3K and p-AKT.	nobiletin	32-41	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	152-157
31082728-9	2019	Importantly, pre-treatment with nobiletin significantly downregulated the myocardial mRNA and protein levels of ERS-related signal molecules, including GRP78, CHOP and caspase-12, but upregulated the levels of p-PI3K and p-AKT.	nobiletin	32-41	DNA-damage inducible transcript 3	Rattus norvegicus	159-163
31082728-9	2019	Importantly, pre-treatment with nobiletin significantly downregulated the myocardial mRNA and protein levels of ERS-related signal molecules, including GRP78, CHOP and caspase-12, but upregulated the levels of p-PI3K and p-AKT.	nobiletin	32-41	caspase 12	Rattus norvegicus	168-178
31082728-9	2019	Importantly, pre-treatment with nobiletin significantly downregulated the myocardial mRNA and protein levels of ERS-related signal molecules, including GRP78, CHOP and caspase-12, but upregulated the levels of p-PI3K and p-AKT.	nobiletin	32-41	AKT serine/threonine kinase 1	Rattus norvegicus	223-226
31082728-11	2019	CONCLUSION: Nobiletin pre-treatment may alleviate MIRI probably via the attenuation of PI3K/AKT-mediated ERS-related myocardial apoptosis.	nobiletin	12-21	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
31117553-5	2019	Our results from Western blot showed that the inhibition of TMAO-induced cardiovascular inflammation was correlated with nobiletin-mediated inhibitory effects on NF-kappaB and MAPK/ERK related pathways.	nobiletin	121-130	Eph receptor B1	Rattus norvegicus	181-184
31354472-0	2019	Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells.	nobiletin	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	42-45
31354472-0	2019	Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	46-49
31354472-0	2019	Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells.	nobiletin	0-9	signal transducer and activator of transcription 3	Homo sapiens	50-55
31354472-0	2019	Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells.	nobiletin	0-9	YY1 associated protein 1	Homo sapiens	56-62
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	107-116	insulin like growth factor 1	Homo sapiens	47-75
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	107-116	insulin like growth factor 1	Homo sapiens	77-81
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	107-116	AKT serine/threonine kinase 1	Homo sapiens	165-168
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	107-116	signal transducer and activator of transcription 3	Homo sapiens	185-190
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	107-116	YY1 associated protein 1	Homo sapiens	211-217
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	267-276	insulin like growth factor 1	Homo sapiens	47-75
31354472-11	2019	The results further showed that application of insulin-like growth factor 1 (IGF1) was able to reverse the nobiletin-induced changes in the levels of phosphorylated AKT, phosphorylated STAT3, and phosphorylated YY1AP1, and could also reverse the antitumor effects of nobiletin.	nobiletin	267-276	insulin like growth factor 1	Homo sapiens	77-81
30951715-6	2019	Furthermore, we observed that pretreatment with nobiletin significantly activated the Akt/GSK-3beta signaling pathway in H/R-stimulated H9c2 cells.	nobiletin	48-57	AKT serine/threonine kinase 1	Rattus norvegicus	86-89
30951715-6	2019	Furthermore, we observed that pretreatment with nobiletin significantly activated the Akt/GSK-3beta signaling pathway in H/R-stimulated H9c2 cells.	nobiletin	48-57	glycogen synthase kinase 3 beta	Rattus norvegicus	90-99
30951715-7	2019	Taken together, these findings demonstrated that nobiletin attenuates myocardial I/R injury via the activation of Akt/GSK-3beta pathway in H9c2 cardiomyocytes.	nobiletin	49-58	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
30951715-7	2019	Taken together, these findings demonstrated that nobiletin attenuates myocardial I/R injury via the activation of Akt/GSK-3beta pathway in H9c2 cardiomyocytes.	nobiletin	49-58	glycogen synthase kinase 3 beta	Rattus norvegicus	118-127
31117553-6	2019	More specifically, nobiletin prevented the oxidative damage of vascular sites (proximal aorta), inhibited the activity of MAPK/ERK, reduced the expression of NF-kappaB p65 and phospho-NF-kappaB p65, and consequently decreased the inflammatory response.	nobiletin	19-28	Eph receptor B1	Rattus norvegicus	127-130
31117553-6	2019	More specifically, nobiletin prevented the oxidative damage of vascular sites (proximal aorta), inhibited the activity of MAPK/ERK, reduced the expression of NF-kappaB p65 and phospho-NF-kappaB p65, and consequently decreased the inflammatory response.	nobiletin	19-28	synaptotagmin 1	Rattus norvegicus	168-171
31117553-6	2019	More specifically, nobiletin prevented the oxidative damage of vascular sites (proximal aorta), inhibited the activity of MAPK/ERK, reduced the expression of NF-kappaB p65 and phospho-NF-kappaB p65, and consequently decreased the inflammatory response.	nobiletin	19-28	synaptotagmin 1	Rattus norvegicus	194-197
29525889-12	2019	In hiFB, the expression of collagen as well as of pro-inflammatory cytokines IL-6, TNF and CCL2 was down-regulated by nobiletin treatment.	nobiletin	118-127	interleukin 6	Mus musculus	77-81
29525889-12	2019	In hiFB, the expression of collagen as well as of pro-inflammatory cytokines IL-6, TNF and CCL2 was down-regulated by nobiletin treatment.	nobiletin	118-127	tumor necrosis factor	Mus musculus	83-86
29525889-12	2019	In hiFB, the expression of collagen as well as of pro-inflammatory cytokines IL-6, TNF and CCL2 was down-regulated by nobiletin treatment.	nobiletin	118-127	chemokine (C-C motif) ligand 2	Mus musculus	91-95
31016813-0	2019	Nobiletin exhibits potent inhibition on tumor necrosis factor alpha-induced calcification of human aortic valve interstitial cells via targeting ABCG2 and AKR1B1.	nobiletin	0-9	tumor necrosis factor	Homo sapiens	40-67
31016813-0	2019	Nobiletin exhibits potent inhibition on tumor necrosis factor alpha-induced calcification of human aortic valve interstitial cells via targeting ABCG2 and AKR1B1.	nobiletin	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	145-150
31016813-0	2019	Nobiletin exhibits potent inhibition on tumor necrosis factor alpha-induced calcification of human aortic valve interstitial cells via targeting ABCG2 and AKR1B1.	nobiletin	0-9	aldo-keto reductase family 1 member B	Homo sapiens	155-161
31016813-3	2019	Tumor necrosis factor-alpha (TNF-alpha)-induced hVICs were treated with or without NBT.	nobiletin	83-86	tumor necrosis factor	Homo sapiens	29-38
31016813-7	2019	NBT interfered with hVIC growth under TNF-alpha condition in a dose-dependent manner also presented a gradual decrease of positive Alizarin Red S staining, down-regulation of BMP2, and RUNX2 gene expression.	nobiletin	0-3	tumor necrosis factor	Homo sapiens	38-47
31214026-0	2019	Nobiletin Inhibits IL-1beta-Induced Inflammation in Chondrocytes via Suppression of NF-kappaB Signaling and Attenuates Osteoarthritis in Mice.	nobiletin	0-9	interleukin 1 beta	Mus musculus	19-27
31214026-9	2019	Induction of proinflammatory and catabolic mediators by IL-1beta stimulation of mouse chondrocytes could be partially blocked by treatment with nobiletin or ammonium pyrrolidine dithiocarbamate (an NF-kappaB inhibitor).	nobiletin	144-153	interleukin 1 beta	Mus musculus	56-64
30864566-0	2019	Nobiletin alleviates vascular alterations through modulation of Nrf-2/HO-1 and MMP pathways in l-NAME induced hypertensive rats.	nobiletin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-69
30864566-0	2019	Nobiletin alleviates vascular alterations through modulation of Nrf-2/HO-1 and MMP pathways in l-NAME induced hypertensive rats.	nobiletin	0-9	heme oxygenase 1	Rattus norvegicus	70-74
30864566-6	2019	Moreover, nobiletin and captopril decreased oxidative stress markers, restored the abnormality of plasma NOx and the protein expressions of eNOS, Nrf-2 and HO-1 observed in l-NAME rats (p < 0.05).	nobiletin	10-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-151
30864566-6	2019	Moreover, nobiletin and captopril decreased oxidative stress markers, restored the abnormality of plasma NOx and the protein expressions of eNOS, Nrf-2 and HO-1 observed in l-NAME rats (p < 0.05).	nobiletin	10-19	heme oxygenase 1	Rattus norvegicus	156-160
30938722-0	2019	Inhibiting the PI3K/AKT/NF-kappaB signal pathway with nobiletin for attenuating the development of osteoarthritis: in vitro and in vivo studies.	nobiletin	54-63	AKT serine/threonine kinase 1	Homo sapiens	20-23
30938722-0	2019	Inhibiting the PI3K/AKT/NF-kappaB signal pathway with nobiletin for attenuating the development of osteoarthritis: in vitro and in vivo studies.	nobiletin	54-63	nuclear factor kappa B subunit 1	Homo sapiens	24-33
30938722-4	2019	In this study, we investigated the anti-inflammatory and chondroprotective effects of NOB on IL-1beta-induced human OA chondrocytes and in the surgical DMM mice OA models.	nobiletin	86-89	interleukin 1 beta	Homo sapiens	93-101
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	nitric oxide synthase 2	Homo sapiens	123-127
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	tumor necrosis factor	Homo sapiens	129-138
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	interleukin 6	Homo sapiens	143-147
30938722-5	2019	In vitro, NOB treatment completely suppressed the overproduction of pro-inflammatory mediators, including PGE2, NO, COX-2, iNOS, TNF-alpha and IL-6 in IL-1beta-induced human OA chondrocytes.	nobiletin	10-13	interleukin 1 beta	Homo sapiens	151-159
30938722-6	2019	Moreover, NOB exerted a potent inhibitory effect on the expression of MMP-13 and ADAMTS-5 as well as the degradation of aggrecan and collagen-II, which leads to the degradation of the extracellular matrix.	nobiletin	10-13	matrix metallopeptidase 13	Homo sapiens	70-76
30938722-6	2019	Moreover, NOB exerted a potent inhibitory effect on the expression of MMP-13 and ADAMTS-5 as well as the degradation of aggrecan and collagen-II, which leads to the degradation of the extracellular matrix.	nobiletin	10-13	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	81-89
30938722-7	2019	Furthermore, NOB dramatically suppressed the IL-1beta-stimulated phosphorylation of PI3K/Akt and activation of NF-kappaB in human OA chondrocytes.	nobiletin	13-16	interleukin 1 beta	Homo sapiens	45-53
30938722-7	2019	Furthermore, NOB dramatically suppressed the IL-1beta-stimulated phosphorylation of PI3K/Akt and activation of NF-kappaB in human OA chondrocytes.	nobiletin	13-16	AKT serine/threonine kinase 1	Homo sapiens	89-92
30938722-7	2019	Furthermore, NOB dramatically suppressed the IL-1beta-stimulated phosphorylation of PI3K/Akt and activation of NF-kappaB in human OA chondrocytes.	nobiletin	13-16	nuclear factor kappa B subunit 1	Homo sapiens	111-120
30959824-9	2019	STAT3 expression was repressed by tangeretin and 5-demethylnobiletin, but not by nobiletin.	nobiletin	59-68	signal transducer and activator of transcription 3	Mus musculus	0-5
31016813-7	2019	NBT interfered with hVIC growth under TNF-alpha condition in a dose-dependent manner also presented a gradual decrease of positive Alizarin Red S staining, down-regulation of BMP2, and RUNX2 gene expression.	nobiletin	0-3	bone morphogenetic protein 2	Homo sapiens	175-179
31016813-7	2019	NBT interfered with hVIC growth under TNF-alpha condition in a dose-dependent manner also presented a gradual decrease of positive Alizarin Red S staining, down-regulation of BMP2, and RUNX2 gene expression.	nobiletin	0-3	RUNX family transcription factor 2	Homo sapiens	185-190
31016813-8	2019	Based on the global gene expression cluster, control and TNF-alpha plus NBT group showed a high similarity versus TNF-alpha only group.	nobiletin	72-75	tumor necrosis factor	Homo sapiens	114-123
30746285-10	2018	The administration of nobiletin and CZP, individually or in combination, downregulated seizure-induced increases in apoptotic cell count and apoptotic protein expression, modulated the expression of gamma-aminobutyric acid (GABA)A and glutamate decarboxylase 65 and restored the glutamate/GABA balance.	nobiletin	22-31	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	199-230
30918653-0	2019	Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway.	nobiletin	0-9	poly(ADP-ribose) polymerase 2	Homo sapiens	116-122
30918653-0	2019	Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666-1 cells through regulating PARP-2/SIRT1/AMPK signaling pathway.	nobiletin	0-9	sirtuin 1	Homo sapiens	123-128
30918653-7	2019	Moreover, nobiletin inhibited the expression of poly(ADP-ribose)polymerase-2 (PARP-2), and the tumor suppression effect of nobiletin on C666-1 is associated with PARP-2-dependent pathway.	nobiletin	10-19	poly(ADP-ribose) polymerase 2	Homo sapiens	48-76
30918653-7	2019	Moreover, nobiletin inhibited the expression of poly(ADP-ribose)polymerase-2 (PARP-2), and the tumor suppression effect of nobiletin on C666-1 is associated with PARP-2-dependent pathway.	nobiletin	10-19	poly(ADP-ribose) polymerase 2	Homo sapiens	78-84
30918653-7	2019	Moreover, nobiletin inhibited the expression of poly(ADP-ribose)polymerase-2 (PARP-2), and the tumor suppression effect of nobiletin on C666-1 is associated with PARP-2-dependent pathway.	nobiletin	123-132	poly(ADP-ribose) polymerase 2	Homo sapiens	162-168
30918653-8	2019	Conclusion: We demonstrated for the first time that nobiletin inhibited the growth of C666-1 cells, which may be relative to its regulation on PARP-2/SIRT1/AMPK signaling pathway.	nobiletin	52-61	poly(ADP-ribose) polymerase 2	Homo sapiens	143-149
30918653-8	2019	Conclusion: We demonstrated for the first time that nobiletin inhibited the growth of C666-1 cells, which may be relative to its regulation on PARP-2/SIRT1/AMPK signaling pathway.	nobiletin	52-61	sirtuin 1	Homo sapiens	150-155
30471854-0	2019	Nobiletin reduces LPL-mediated lipid accumulation and pro-inflammatory cytokine secretion through upregulation of miR-590 expression.	nobiletin	0-9	lipoprotein lipase	Homo sapiens	18-21
30471854-0	2019	Nobiletin reduces LPL-mediated lipid accumulation and pro-inflammatory cytokine secretion through upregulation of miR-590 expression.	nobiletin	0-9	microRNA 590	Homo sapiens	114-121
30471854-2	2019	In this study, we examined whether nobiletin affects the expression of miR-590/LPL and its relative effects on lipid accumulation and pro-inflammatory cytokine secretion in human THP-1 macrophages.	nobiletin	35-44	microRNA 590	Homo sapiens	71-78
30471854-2	2019	In this study, we examined whether nobiletin affects the expression of miR-590/LPL and its relative effects on lipid accumulation and pro-inflammatory cytokine secretion in human THP-1 macrophages.	nobiletin	35-44	lipoprotein lipase	Homo sapiens	79-82
30471854-8	2019	In conclusion, nobiletin may alleviate lipid accumulation and secretion of pro-inflammatory cytokines by enhancing the inhibitory effect of miR-590 on LPL expression, suggesting a promising strategy for potential drug development for atherosclerosis.	nobiletin	15-24	microRNA 590	Homo sapiens	140-147
30471854-8	2019	In conclusion, nobiletin may alleviate lipid accumulation and secretion of pro-inflammatory cytokines by enhancing the inhibitory effect of miR-590 on LPL expression, suggesting a promising strategy for potential drug development for atherosclerosis.	nobiletin	15-24	lipoprotein lipase	Homo sapiens	151-154
30468657-0	2019	Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	68-71
30468657-0	2019	Nobiletin sensitizes colorectal cancer cells to oxaliplatin by PI3K/Akt/MTOR pathway.	nobiletin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	72-76
30468657-6	2019	Meanwhile, nobiletin promoted oxaliplatin-induced apoptosis of CRC cells, as demonstrated by the increased expression of pro-apoptotic proteins (Bax and cleaved-caspse3) and the down-regulation of anti-apoptotic protein Bcl-2.	nobiletin	11-20	BCL2 associated X, apoptosis regulator	Homo sapiens	145-148
30468657-6	2019	Meanwhile, nobiletin promoted oxaliplatin-induced apoptosis of CRC cells, as demonstrated by the increased expression of pro-apoptotic proteins (Bax and cleaved-caspse3) and the down-regulation of anti-apoptotic protein Bcl-2.	nobiletin	11-20	BCL2 apoptosis regulator	Homo sapiens	220-225
31257269-0	2019	Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin.	nobiletin	0-9	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	96-105
31257269-1	2019	We examined the effect of nobiletin (5,6,7,8,3",4"-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice.	nobiletin	26-35	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	93-102
31257269-2	2019	Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production.	nobiletin	15-24	interleukin 4	Mus musculus	48-52
31257269-2	2019	Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production.	nobiletin	15-24	interleukin 10	Mus musculus	57-62
31257269-3	2019	In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 production than did control mice.	nobiletin	32-41	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	92-96
30746285-11	2018	Nobiletin and CZP administration significantly upregulated phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling.	nobiletin	0-9	thymoma viral proto-oncogene 1	Mus musculus	108-111
30507186-3	2018	We demonstrated that nobiletin (0-100 muM) significantly reduced cell viability from 100.0 +- 9.6% to 31.1 +- 2.8% in human AML THP-1 cell line.	nobiletin	21-30	latexin	Homo sapiens	38-41
30507186-6	2018	Furthermore, we verified that AML cells treated with nobiletin (40 and 80 muM) for 48 h markedly suppressed c-KIT mRNA expression (from 1.00 +- 0.07-fold to 0.62 +- 0.08- and 0.30 +- 0.05-fold) and reduced the level of c-KIT protein expression (from 1.00 +- 0.11-fold to 0.60 +- 0.15- and 0.34 +- 0.05-fold) by inhibition of KIT promoter activity.	nobiletin	53-62	latexin	Homo sapiens	74-77
30507186-6	2018	Furthermore, we verified that AML cells treated with nobiletin (40 and 80 muM) for 48 h markedly suppressed c-KIT mRNA expression (from 1.00 +- 0.07-fold to 0.62 +- 0.08- and 0.30 +- 0.05-fold) and reduced the level of c-KIT protein expression (from 1.00 +- 0.11-fold to 0.60 +- 0.15- and 0.34 +- 0.05-fold) by inhibition of KIT promoter activity.	nobiletin	53-62	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	108-113
30507186-6	2018	Furthermore, we verified that AML cells treated with nobiletin (40 and 80 muM) for 48 h markedly suppressed c-KIT mRNA expression (from 1.00 +- 0.07-fold to 0.62 +- 0.08- and 0.30 +- 0.05-fold) and reduced the level of c-KIT protein expression (from 1.00 +- 0.11-fold to 0.60 +- 0.15- and 0.34 +- 0.05-fold) by inhibition of KIT promoter activity.	nobiletin	53-62	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	219-224
30507186-8	2018	Moreover, we found that the overexpression of c-KIT abolished nobiletin-mediated cell growth inhibition in leukemia cells.	nobiletin	62-71	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	46-51
30058806-0	2018	Nobiletin and 5-Hydroxy-6,7,8,3",4"-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4+ T Cells through Mitogen-Activated Protein Kinase Signaling Pathways.	nobiletin	0-9	antigen identified by monoclonal antibody Ki 67	Mus musculus	179-184
30203502-7	2018	Furthermore, nobiletin suppressed the activation of NF-kappaB and Wnt/beta-catenin signaling pathways in hypoxia-stimulated RCC cells.	nobiletin	13-22	catenin beta 1	Homo sapiens	70-82
30203502-8	2018	In conclusion, these findings demonstrate that nobiletin inhibits hypoxia-induced EMT in human RCC cells via the inactivation of the NF-kappaB and Wnt/beta-catenin signaling pathways.	nobiletin	47-56	catenin beta 1	Homo sapiens	151-163
30387829-0	2018	Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a sirtuin 1-dependent manner in AML-12 cells.	nobiletin	0-9	NLR family, pyrin domain containing 3	Mus musculus	43-48
30387829-0	2018	Nobiletin alleviates palmitic acid-induced NLRP3 inflammasome activation in a sirtuin 1-dependent manner in AML-12 cells.	nobiletin	0-9	sirtuin 1	Mus musculus	78-87
30387829-9	2018	Furthermore, Nob treatment with or without PA enhanced the expression of SIRT1 in AML-12 cells, while knockdown of SIRT1 with SIRT1-small interfering RNA reversed the anti-inflammatory effects of Nob.	nobiletin	13-16	sirtuin 1	Mus musculus	73-78
30486290-0	2018	Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3beta/beta-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	76-79
30486290-0	2018	Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3beta/beta-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells.	nobiletin	0-9	glycogen synthase kinase 3 beta	Homo sapiens	80-88
30486290-0	2018	Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3beta/beta-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells.	nobiletin	0-9	catenin beta 1	Homo sapiens	89-101
30486290-0	2018	Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3beta/beta-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells.	nobiletin	0-9	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	102-106
30486290-0	2018	Nobiletin Enhances Chemosensitivity to Adriamycin through Modulation of the Akt/GSK3beta/beta-Catenin/MYCN/MRP1 Signaling Pathway in A549 Human Non-Small-Cell Lung Cancer Cells.	nobiletin	0-9	ATP binding cassette subfamily C member 1	Homo sapiens	107-111
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	66-69
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	71-75
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	ATP binding cassette subfamily C member 1	Homo sapiens	81-122
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	ATP binding cassette subfamily C member 1	Homo sapiens	124-128
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	AKT serine/threonine kinase 1	Homo sapiens	156-159
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	glycogen synthase kinase 3 beta	Homo sapiens	161-169
30486290-4	2018	NBT treatment decreased the expression of a neuroblastoma-derived MYC (MYCN) and multidrug resistance-associated protein 1 (MRP1) as well as downregulating Akt, GSK3beta, and beta-catenin.	nobiletin	0-3	catenin beta 1	Homo sapiens	175-187
30486290-7	2018	Combined treatment with NBT and ADR enhanced apoptosis in A549/ADR cells, as evidenced by increased caspase-3 activation, poly (ADP-ribose) polymerase (PARP) cleavage, and sub-G1 population compared to treatment with ADR alone.	nobiletin	24-27	poly(ADP-ribose) polymerase 1	Homo sapiens	152-156
30486290-9	2018	These data suggest that NBT can sensitize ADR-induced cytotoxicity against A549/ADR cells by inhibiting MRP1 expression, indicating that NBT could serve as an effective adjuvant agent for ADR-based chemotherapy in lung cancer.	nobiletin	24-27	ATP binding cassette subfamily C member 1	Homo sapiens	104-108
30486290-9	2018	These data suggest that NBT can sensitize ADR-induced cytotoxicity against A549/ADR cells by inhibiting MRP1 expression, indicating that NBT could serve as an effective adjuvant agent for ADR-based chemotherapy in lung cancer.	nobiletin	137-140	ATP binding cassette subfamily C member 1	Homo sapiens	104-108
30574046-0	2018	Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-kappaB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells.	nobiletin	0-9	mitogen-activated protein kinase 14	Homo sapiens	37-73
30574046-0	2018	Nobiletin inhibits breast cancer via p38 mitogen-activated protein kinase, nuclear transcription factor-kappaB, and nuclear factor erythroid 2-related factor 2 pathways in MCF-7 cells.	nobiletin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	116-159
30574046-4	2018	Nobiletin induced apoptosis of breast cancer MCF-7 cells via regulating the protein expression of Bax, Bcl-2, cleaved caspase-3, and p53.	nobiletin	0-9	BCL2 associated X, apoptosis regulator	Homo sapiens	98-101
30574046-4	2018	Nobiletin induced apoptosis of breast cancer MCF-7 cells via regulating the protein expression of Bax, Bcl-2, cleaved caspase-3, and p53.	nobiletin	0-9	BCL2 apoptosis regulator	Homo sapiens	103-108
30574046-4	2018	Nobiletin induced apoptosis of breast cancer MCF-7 cells via regulating the protein expression of Bax, Bcl-2, cleaved caspase-3, and p53.	nobiletin	0-9	tumor protein p53	Homo sapiens	133-136
30574046-5	2018	The expression of Bcl-2 decreased, while the expression of Bax and p53 increased in MCF-7 cells treated with nobiletin.	nobiletin	109-118	BCL2 apoptosis regulator	Homo sapiens	18-23
30574046-5	2018	The expression of Bcl-2 decreased, while the expression of Bax and p53 increased in MCF-7 cells treated with nobiletin.	nobiletin	109-118	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
30574046-5	2018	The expression of Bcl-2 decreased, while the expression of Bax and p53 increased in MCF-7 cells treated with nobiletin.	nobiletin	109-118	tumor protein p53	Homo sapiens	67-70
30574046-6	2018	Meanwhile, nobiletin inhibited cell migration by downregulating the protein expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9).	nobiletin	11-20	matrix metallopeptidase 2	Homo sapiens	90-116
30574046-6	2018	Meanwhile, nobiletin inhibited cell migration by downregulating the protein expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9).	nobiletin	11-20	matrix metallopeptidase 2	Homo sapiens	118-123
30574046-6	2018	Meanwhile, nobiletin inhibited cell migration by downregulating the protein expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9).	nobiletin	11-20	matrix metallopeptidase 9	Homo sapiens	129-155
30574046-6	2018	Meanwhile, nobiletin inhibited cell migration by downregulating the protein expression of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9).	nobiletin	11-20	matrix metallopeptidase 9	Homo sapiens	157-162
30058806-0	2018	Nobiletin and 5-Hydroxy-6,7,8,3",4"-pentamethoxyflavone Ameliorate 12- O-Tetradecanoylphorbol-13-acetate-Induced Psoriasis-Like Mouse Skin Lesions by Regulating the Expression of Ki-67 and Proliferating Cell Nuclear Antigen and the Differentiation of CD4+ T Cells through Mitogen-Activated Protein Kinase Signaling Pathways.	nobiletin	0-9	proliferating cell nuclear antigen	Mus musculus	189-223
30058806-5	2018	Levels of cytokines, including interleukin (IL)-1beta, IL-17, IL-4, IL-6, tumor necrosis factor-alpha, and interferon-gamma, were also reduced after Nob and 5-HPMF treatment.	nobiletin	149-152	interleukin 17A	Mus musculus	55-60
30058806-5	2018	Levels of cytokines, including interleukin (IL)-1beta, IL-17, IL-4, IL-6, tumor necrosis factor-alpha, and interferon-gamma, were also reduced after Nob and 5-HPMF treatment.	nobiletin	149-152	interleukin 4	Mus musculus	62-66
30058806-5	2018	Levels of cytokines, including interleukin (IL)-1beta, IL-17, IL-4, IL-6, tumor necrosis factor-alpha, and interferon-gamma, were also reduced after Nob and 5-HPMF treatment.	nobiletin	149-152	interleukin 6	Mus musculus	68-72
30058806-5	2018	Levels of cytokines, including interleukin (IL)-1beta, IL-17, IL-4, IL-6, tumor necrosis factor-alpha, and interferon-gamma, were also reduced after Nob and 5-HPMF treatment.	nobiletin	149-152	tumor necrosis factor	Mus musculus	74-101
30058806-5	2018	Levels of cytokines, including interleukin (IL)-1beta, IL-17, IL-4, IL-6, tumor necrosis factor-alpha, and interferon-gamma, were also reduced after Nob and 5-HPMF treatment.	nobiletin	149-152	interferon gamma	Mus musculus	107-123
30058806-6	2018	The expression levels of p-ERK1/2 and p-p38 mitogen-activated protein kinase (MAPK) in the TPA group were 5.3, 4.8, and 5.7 but downregulated to 2.7, 2.9, and 2.3 in the Nob group and 2.4, 2.7, and 1.2 in the 5-HPMF group, respectively ( p <= 0.05).	nobiletin	170-173	mitogen-activated protein kinase 3	Mus musculus	27-33
30058806-6	2018	The expression levels of p-ERK1/2 and p-p38 mitogen-activated protein kinase (MAPK) in the TPA group were 5.3, 4.8, and 5.7 but downregulated to 2.7, 2.9, and 2.3 in the Nob group and 2.4, 2.7, and 1.2 in the 5-HPMF group, respectively ( p <= 0.05).	nobiletin	170-173	mitogen-activated protein kinase 1	Mus musculus	78-82
30058806-8	2018	The expression levels in TPA, Nob, and 5-HPMF groups were 0.649 +- 0.094, 0.218 +- 0.034, and 0.193 +- 0.042 for Ki-67 and 0.753 +- 0.114, 0.315 +- 0.094, and 0.294 +- 0.035 for PCNA, respectively.	nobiletin	30-33	antigen identified by monoclonal antibody Ki 67	Mus musculus	113-118
30058806-8	2018	The expression levels in TPA, Nob, and 5-HPMF groups were 0.649 +- 0.094, 0.218 +- 0.034, and 0.193 +- 0.042 for Ki-67 and 0.753 +- 0.114, 0.315 +- 0.094, and 0.294 +- 0.035 for PCNA, respectively.	nobiletin	30-33	proliferating cell nuclear antigen	Mus musculus	178-182
29687528-5	2018	Nobiletin inhibited H2 O2 -induced ROS production and caspase-3/7 activity in ARPE-19 cells.	nobiletin	0-9	caspase 3	Homo sapiens	54-63
30008441-3	2018	Previous prevention studies demonstrated that the citrus flavonoids, naringenin and nobiletin, protect against obesity and metabolic dysfunction in Ldlr-/- mice fed a high-fat cholesterol-containing (HFHC) diet.	nobiletin	84-93	low density lipoprotein receptor	Mus musculus	148-152
30116396-0	2018	Nobiletin protects PC12 cells from ERS-induced apoptosis in OGD/R injury via activation of the PI3K/AKT pathway.	nobiletin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	100-103
30116396-11	2018	Mechanistic detections showed that the neuron-favorable and ERS-repressing contributions of NOB were, in part, a result of the activation of the PI3K/AKT pathway, which was validated by a specific PI3K/AKT inhibitor (LY294002).	nobiletin	92-95	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
30116396-11	2018	Mechanistic detections showed that the neuron-favorable and ERS-repressing contributions of NOB were, in part, a result of the activation of the PI3K/AKT pathway, which was validated by a specific PI3K/AKT inhibitor (LY294002).	nobiletin	92-95	AKT serine/threonine kinase 1	Rattus norvegicus	202-205
29635125-0	2018	Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	70-73
29635125-0	2018	Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells.	nobiletin	11-14	AKT serine/threonine kinase 1	Homo sapiens	70-73
29635125-6	2018	In the present study, NOB selectively suppressed the growth and proliferation of human SKOV3/TAX cells, inducing G0/G1 phase arrest and reducing G2/M phase, along with the increase of p53 and p21.	nobiletin	22-25	tumor protein p53	Homo sapiens	184-187
29635125-6	2018	In the present study, NOB selectively suppressed the growth and proliferation of human SKOV3/TAX cells, inducing G0/G1 phase arrest and reducing G2/M phase, along with the increase of p53 and p21.	nobiletin	22-25	H3 histone pseudogene 16	Homo sapiens	192-195
29635125-7	2018	In addition, NOB induced significant apoptosis in SKOV3/TAX cells through the intrinsic apoptosis pathway, as evidenced by the up-regulation of cleaved Caspase-9/-3 and PARP.	nobiletin	13-16	caspase 9	Homo sapiens	152-164
29635125-7	2018	In addition, NOB induced significant apoptosis in SKOV3/TAX cells through the intrinsic apoptosis pathway, as evidenced by the up-regulation of cleaved Caspase-9/-3 and PARP.	nobiletin	13-16	poly(ADP-ribose) polymerase 1	Homo sapiens	169-173
29871974-0	2018	Nobiletin alleviates endometriosis via down-regulating NF-kappaB activity in endometriosis mouse model.	nobiletin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	55-64
29871974-1	2018	Nobiletin exhibits protective potential on inflammation and inhibits the activation of transcription factors nuclear factor-kappaB (NF-kappaB).	nobiletin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-141
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	proliferating cell nuclear antigen	Mus musculus	50-54
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	vascular endothelial growth factor A	Mus musculus	56-60
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	cadherin 1	Mus musculus	66-76
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	interleukin 6	Mus musculus	126-130
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	interleukin 1 beta	Mus musculus	132-140
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	tumor necrosis factor	Mus musculus	142-151
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	matrix metallopeptidase 13	Mus musculus	153-158
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	matrix metallopeptidase 3	Mus musculus	164-169
29501626-5	2018	Importantly, NOB was found to be effective at amplifying glucose uptake via stimulating IRS-1/AKT signaling pathway, as well as blunting palmitate-induced lipogenesis in HepG2 cells via modulating AMPK-Sirt1 signaling pathway and key enzymes of de novo lipogenesis in a Bmal1-dependent manner.	nobiletin	13-16	insulin receptor substrate 1	Homo sapiens	88-93
29501626-5	2018	Importantly, NOB was found to be effective at amplifying glucose uptake via stimulating IRS-1/AKT signaling pathway, as well as blunting palmitate-induced lipogenesis in HepG2 cells via modulating AMPK-Sirt1 signaling pathway and key enzymes of de novo lipogenesis in a Bmal1-dependent manner.	nobiletin	13-16	AKT serine/threonine kinase 1	Homo sapiens	94-97
29501626-5	2018	Importantly, NOB was found to be effective at amplifying glucose uptake via stimulating IRS-1/AKT signaling pathway, as well as blunting palmitate-induced lipogenesis in HepG2 cells via modulating AMPK-Sirt1 signaling pathway and key enzymes of de novo lipogenesis in a Bmal1-dependent manner.	nobiletin	13-16	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	270-275
29501626-7	2018	CONCLUSION: This study is the first to provide compelling evidences that NOB prevent cellular glucolipid metabolic imbalance and mitochondrial function in a Bmal1-dependent manner.	nobiletin	73-76	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	157-162
29489460-15	2018	Using the small molecule nobiletin to enhance PER2 function, the cognitive deficits induced by midazolam or constant light were attenuated in wild-type mice.	nobiletin	25-34	period circadian clock 2	Mus musculus	46-50
29541888-0	2018	Nobiletin-Ameliorated Lipopolysaccharide-Induced Inflammation in Acute Lung Injury by Suppression of NF-kappaB Pathway In Vivo and Vitro.	nobiletin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
29541888-6	2018	Results suggested that treatment with NOB dramatically attenuated lung histopathological changes, wet-to-dry (W/D) ratio, myeloperoxidase (MPO) activity, the numbers of inflammatory cells, and TNF-alpha, IL-6, and NO in BALF induced by LPS.	nobiletin	38-41	myeloperoxidase	Mus musculus	122-137
29541888-6	2018	Results suggested that treatment with NOB dramatically attenuated lung histopathological changes, wet-to-dry (W/D) ratio, myeloperoxidase (MPO) activity, the numbers of inflammatory cells, and TNF-alpha, IL-6, and NO in BALF induced by LPS.	nobiletin	38-41	myeloperoxidase	Mus musculus	139-142
29541888-6	2018	Results suggested that treatment with NOB dramatically attenuated lung histopathological changes, wet-to-dry (W/D) ratio, myeloperoxidase (MPO) activity, the numbers of inflammatory cells, and TNF-alpha, IL-6, and NO in BALF induced by LPS.	nobiletin	38-41	tumor necrosis factor	Mus musculus	193-202
29541888-6	2018	Results suggested that treatment with NOB dramatically attenuated lung histopathological changes, wet-to-dry (W/D) ratio, myeloperoxidase (MPO) activity, the numbers of inflammatory cells, and TNF-alpha, IL-6, and NO in BALF induced by LPS.	nobiletin	38-41	interleukin 6	Mus musculus	204-208
29541888-7	2018	Furthermore, NOB also significantly inhibited the expression of iNOS and the phosphorylation of NF-kappaBp65 and IkappaBalpha.	nobiletin	13-16	nitric oxide synthase 2, inducible	Mus musculus	64-68
29541888-7	2018	Furthermore, NOB also significantly inhibited the expression of iNOS and the phosphorylation of NF-kappaBp65 and IkappaBalpha.	nobiletin	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	96-125
29541888-8	2018	In vitro, NOB inhibited NF-kappaB activation and TNF-alpha, IL-6 production in LPS-stimulated A549 cells.	nobiletin	10-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-33
29541888-8	2018	In vitro, NOB inhibited NF-kappaB activation and TNF-alpha, IL-6 production in LPS-stimulated A549 cells.	nobiletin	10-13	tumor necrosis factor	Mus musculus	49-58
29541888-8	2018	In vitro, NOB inhibited NF-kappaB activation and TNF-alpha, IL-6 production in LPS-stimulated A549 cells.	nobiletin	10-13	interleukin 6	Mus musculus	60-64
29541888-9	2018	Taken together, these results indicated that NOB exhibited a protective effect on ALI, and the possible mechanism is involved in inhibiting NF-kappaB activation, subsequently inhibiting LPS-induced inflammatory response.	nobiletin	45-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
29687528-7	2018	Meanwhile, LY294002, an inhibitor of PI3K/Akt, abolished the protective effect of nobiletin against H2 O2 -induced decreased cell viability and increased caspase-3/7 activity in ARPE-19 cells.	nobiletin	82-91	AKT serine/threonine kinase 1	Homo sapiens	42-45
29687528-7	2018	Meanwhile, LY294002, an inhibitor of PI3K/Akt, abolished the protective effect of nobiletin against H2 O2 -induced decreased cell viability and increased caspase-3/7 activity in ARPE-19 cells.	nobiletin	82-91	caspase 3	Homo sapiens	154-163
29217172-9	2018	Moreover, nobiletin ameliorated stress in adipocytes by inhibiting expression levels of key stress molecules such as JNK and c-JUN.	nobiletin	10-19	mitogen-activated protein kinase 8	Homo sapiens	117-120
29217172-9	2018	Moreover, nobiletin ameliorated stress in adipocytes by inhibiting expression levels of key stress molecules such as JNK and c-JUN.	nobiletin	10-19	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
29217172-10	2018	Nobiletin-induced browning could be mediated by tight regulation of kinases, as nobiletin induced PKA and p-AMPK at the protein expression level, and inhibition of PKA and p-AMPK by H-89 and dorsomorphin, respectively, abolished expression of the thermogenic markers PGC-1alpha and UCP1.	nobiletin	0-9	PPARG coactivator 1 alpha	Homo sapiens	267-277
29217172-10	2018	Nobiletin-induced browning could be mediated by tight regulation of kinases, as nobiletin induced PKA and p-AMPK at the protein expression level, and inhibition of PKA and p-AMPK by H-89 and dorsomorphin, respectively, abolished expression of the thermogenic markers PGC-1alpha and UCP1.	nobiletin	0-9	uncoupling protein 1	Homo sapiens	282-286
29408579-6	2018	In MDA-MB-468 cells that were coincubated with the CYP1 inhibitor acacetin, an approximately 300-fold increase was noted in the IC50 (30 +- 2.4 muM) of nobiletin.	nobiletin	152-161	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-55
29408579-0	2018	Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.	nobiletin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	77-81
29408579-3	2018	Nobiletin was metabolized in MDA-MB-468 cells to a single-demethylated derivative assigned NP1.	nobiletin	0-9	neuronal pentraxin 1	Homo sapiens	91-94
29408579-6	2018	In MDA-MB-468 cells that were coincubated with the CYP1 inhibitor acacetin, an approximately 300-fold increase was noted in the IC50 (30 +- 2.4 muM) of nobiletin.	nobiletin	152-161	latexin	Homo sapiens	144-147
29408579-7	2018	In the presence of the CYP1 inhibitor acacetin, the conversion of nobiletin to NP1 was significantly reduced in MDA-MB-468 cells.	nobiletin	66-75	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	23-27
29408579-7	2018	In the presence of the CYP1 inhibitor acacetin, the conversion of nobiletin to NP1 was significantly reduced in MDA-MB-468 cells.	nobiletin	66-75	neuronal pentraxin 1	Homo sapiens	79-82
29408579-8	2018	Furthermore, a significant increase was noted in the population of the cells at the G1 phase, following treatment with nobiletin (10 muM) for 24 h compared with the control cells treated with DMSO (0.1%) alone (55.9 +- 0.14 vs. 45.6 +- 1.96), whereas the cell cycle of MCF10A cells was not significantly altered under the same treatment conditions.	nobiletin	119-128	latexin	Homo sapiens	133-136
29408579-9	2018	Taken collectively, the results suggest that nobiletin is selectively bioactivated in MDA-MB-468 breast cancer cells via metabolism by the cytochrome P450 CYP1 family of enzymes.	nobiletin	45-54	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	155-159
29334873-11	2018	Nobiletin significantly blocked the activation of Akt/mTOR signaling.	nobiletin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	50-53
29334873-11	2018	Nobiletin significantly blocked the activation of Akt/mTOR signaling.	nobiletin	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	54-58
29552085-0	2018	Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase.	nobiletin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	57-85
29552085-6	2018	Nobiletin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase.	nobiletin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	57-85
29552085-6	2018	Nobiletin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase.	nobiletin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	87-91
29552085-7	2018	Pretreatment with compound C, an AMPK inhibitor, abolished the inhibitory effects of nobiletin on SREBP-1c and FAS expression.	nobiletin	85-94	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	33-37
29552085-7	2018	Pretreatment with compound C, an AMPK inhibitor, abolished the inhibitory effects of nobiletin on SREBP-1c and FAS expression.	nobiletin	85-94	sterol regulatory element binding transcription factor 1	Homo sapiens	98-106
29552085-7	2018	Pretreatment with compound C, an AMPK inhibitor, abolished the inhibitory effects of nobiletin on SREBP-1c and FAS expression.	nobiletin	85-94	fatty acid synthase	Homo sapiens	111-114
29552085-8	2018	These results suggested that nobiletin might attenuate high glucose-induced lipid accumulation in HepG2 hepatocytes via modulation of AMPK signaling pathway.	nobiletin	29-38	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	134-138
28830813-6	2017	The impaired autophagy flux due to ischemia was ameliorated after Nobiletin treatment by testing the autophagy substrate, LC3BII and P62 protein level both in vivo and in vitro.	nobiletin	66-75	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	133-136
29160881-6	2017	These results demonstrated that nobiletin inhibited the development of RA by inhibiting the degree of angiogenesis and inflammatory infiltration by down-regulating the protein expression level of the p38/nuclear factor kappa B (NF-kappaB) signaling pathway in the synovium of rats with CIA.	nobiletin	32-41	mitogen activated protein kinase 14	Rattus norvegicus	200-203
28623785-5	2017	Therefore, the pharmacological inhibitory effect of gelatinases on retinal MMP-producing cells may be useful in the treatment or prevention of DR. Nobiletin isolated from citrus plants is a multi-functional polymethoxylated flavone, which exerts biological effects including inhibitory action against MMP activity in several cancer cells.	nobiletin	147-156	matrix metallopeptidase 2	Homo sapiens	75-78
28623785-5	2017	Therefore, the pharmacological inhibitory effect of gelatinases on retinal MMP-producing cells may be useful in the treatment or prevention of DR. Nobiletin isolated from citrus plants is a multi-functional polymethoxylated flavone, which exerts biological effects including inhibitory action against MMP activity in several cancer cells.	nobiletin	147-156	matrix metallopeptidase 2	Homo sapiens	301-304
28623785-8	2017	In addition, we observed the augmentation of inhibitory action against MMP-9 enzymatic activity by 4"-demethylated nobiletin, which is a major metabolite of nobiletin.	nobiletin	115-124	matrix metallopeptidase 9	Homo sapiens	71-76
28623785-11	2017	These results suggested that nobiletin, derived from a natural source, may serve as a novel MMP inhibitor with minimal side effects, and lead compound for the design of more efficacious drugs.	nobiletin	29-38	matrix metallopeptidase 2	Homo sapiens	92-95
28892456-0	2017	Nobiletin Attenuates the Inflammatory Response Through Heme Oxygenase-1 Induction in the Crosstalk Between Adipocytes and Macrophages.	nobiletin	0-9	heme oxygenase 1	Mus musculus	55-71
28892456-3	2017	The results showed that nobiletin significantly and dose-dependently inhibited the secretion of inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-alpha), and monocyte chemoattractant protein (MCP)-1, in a coculture of adipocytes and macrophages.	nobiletin	24-33	tumor necrosis factor	Mus musculus	147-168
28892456-3	2017	The results showed that nobiletin significantly and dose-dependently inhibited the secretion of inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-alpha), and monocyte chemoattractant protein (MCP)-1, in a coculture of adipocytes and macrophages.	nobiletin	24-33	tumor necrosis factor	Mus musculus	170-179
28892456-3	2017	The results showed that nobiletin significantly and dose-dependently inhibited the secretion of inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-alpha), and monocyte chemoattractant protein (MCP)-1, in a coculture of adipocytes and macrophages.	nobiletin	24-33	chemokine (C-C motif) ligand 2	Mus musculus	186-226
28892456-5	2017	Nobiletin also downregulated the expression of inducible NO synthase in cocultured differentiated RAW264.7 cells.	nobiletin	0-9	nitric oxide synthase 2, inducible	Mus musculus	47-68
28892456-6	2017	Furthermore, heme oxygenase-1 (HO-1) was significantly induced by nobiletin treatment in both cell types, and small interfering (si) RNA-mediated knockdown of HO-1 significantly recovered the inhibitory effects of nobiletin on the NO production in cocultured cells.	nobiletin	66-75	heme oxygenase 1	Mus musculus	13-29
28892456-6	2017	Furthermore, heme oxygenase-1 (HO-1) was significantly induced by nobiletin treatment in both cell types, and small interfering (si) RNA-mediated knockdown of HO-1 significantly recovered the inhibitory effects of nobiletin on the NO production in cocultured cells.	nobiletin	66-75	heme oxygenase 1	Mus musculus	31-35
28892456-6	2017	Furthermore, heme oxygenase-1 (HO-1) was significantly induced by nobiletin treatment in both cell types, and small interfering (si) RNA-mediated knockdown of HO-1 significantly recovered the inhibitory effects of nobiletin on the NO production in cocultured cells.	nobiletin	214-223	heme oxygenase 1	Mus musculus	13-29
28892456-6	2017	Furthermore, heme oxygenase-1 (HO-1) was significantly induced by nobiletin treatment in both cell types, and small interfering (si) RNA-mediated knockdown of HO-1 significantly recovered the inhibitory effects of nobiletin on the NO production in cocultured cells.	nobiletin	214-223	heme oxygenase 1	Mus musculus	31-35
28892456-6	2017	Furthermore, heme oxygenase-1 (HO-1) was significantly induced by nobiletin treatment in both cell types, and small interfering (si) RNA-mediated knockdown of HO-1 significantly recovered the inhibitory effects of nobiletin on the NO production in cocultured cells.	nobiletin	214-223	heme oxygenase 1	Mus musculus	159-163
28892456-7	2017	These results suggest that nobiletin exerts anti-inflammatory effects on the crosstalk between adipocytes and macrophages by inducing HO-1.	nobiletin	27-36	heme oxygenase 1	Mus musculus	134-138
28273635-7	2017	Results showed nobiletin dose-dependently suppressed the expression of inflammatory mediators and the activity of TLR4/NF-kappaB signaling pathway in activated KCs.	nobiletin	15-24	toll-like receptor 4	Rattus norvegicus	114-118
28478273-0	2017	Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-kappaB signaling in ischemic brain injury in rats.	nobiletin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
28478273-0	2017	Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-kappaB signaling in ischemic brain injury in rats.	nobiletin	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	71-75
28478273-0	2017	Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-kappaB signaling in ischemic brain injury in rats.	nobiletin	0-9	toll-like receptor 4	Rattus norvegicus	80-85
28478273-14	2017	Propofol either alone or with prior nobiletin treatment had down-regulated TLR4 and TLR4-mediated NF-kappaB signaling and caused activation of Akt/mTOR cascade.	nobiletin	36-45	toll-like receptor 4	Rattus norvegicus	75-79
28478273-14	2017	Propofol either alone or with prior nobiletin treatment had down-regulated TLR4 and TLR4-mediated NF-kappaB signaling and caused activation of Akt/mTOR cascade.	nobiletin	36-45	toll-like receptor 4	Rattus norvegicus	84-88
28478273-14	2017	Propofol either alone or with prior nobiletin treatment had down-regulated TLR4 and TLR4-mediated NF-kappaB signaling and caused activation of Akt/mTOR cascade.	nobiletin	36-45	AKT serine/threonine kinase 1	Rattus norvegicus	143-146
28478273-14	2017	Propofol either alone or with prior nobiletin treatment had down-regulated TLR4 and TLR4-mediated NF-kappaB signaling and caused activation of Akt/mTOR cascade.	nobiletin	36-45	mechanistic target of rapamycin kinase	Rattus norvegicus	147-151
28107678-0	2017	Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression.	nobiletin	0-9	nitric oxide synthase 2, inducible	Mus musculus	106-110
28339056-0	2017	Nobiletin inhibits invasion via inhibiting AKT/GSK3beta/beta-catenin signaling pathway in Slug-expressing glioma cells.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	43-46
28339056-0	2017	Nobiletin inhibits invasion via inhibiting AKT/GSK3beta/beta-catenin signaling pathway in Slug-expressing glioma cells.	nobiletin	0-9	glycogen synthase kinase 3 beta	Homo sapiens	47-55
28339056-0	2017	Nobiletin inhibits invasion via inhibiting AKT/GSK3beta/beta-catenin signaling pathway in Slug-expressing glioma cells.	nobiletin	0-9	catenin beta 1	Homo sapiens	56-68
28339056-0	2017	Nobiletin inhibits invasion via inhibiting AKT/GSK3beta/beta-catenin signaling pathway in Slug-expressing glioma cells.	nobiletin	0-9	snail family transcriptional repressor 2	Homo sapiens	90-94
28339056-3	2017	Expression of epithelial markers (E-cadherin and occludin) was upregulated; mesenchymal markers (N-cadherin, fibronectin) and the transcriptional factor Slug were downregulated after nobiletin treatment.	nobiletin	183-192	cadherin 2	Homo sapiens	97-107
28339056-6	2017	It is worth noting that nobiletin almost blocked invasion in Slug-expressing U87 and U251 cells, and only exhibiting faint effect on non-Slug-expressing U343 glioma cells.	nobiletin	24-33	snail family transcriptional repressor 2	Homo sapiens	61-65
28339056-7	2017	Reinforced Slug expression in U343 cells by transfecting Slug plasmid was significantly attenuated by nobiletin, demonstrating the essential role of Slug in the anti-metastasis effect of nobiletin.	nobiletin	102-111	snail family transcriptional repressor 2	Homo sapiens	11-15
28339056-7	2017	Reinforced Slug expression in U343 cells by transfecting Slug plasmid was significantly attenuated by nobiletin, demonstrating the essential role of Slug in the anti-metastasis effect of nobiletin.	nobiletin	102-111	snail family transcriptional repressor 2	Homo sapiens	57-61
28339056-7	2017	Reinforced Slug expression in U343 cells by transfecting Slug plasmid was significantly attenuated by nobiletin, demonstrating the essential role of Slug in the anti-metastasis effect of nobiletin.	nobiletin	102-111	snail family transcriptional repressor 2	Homo sapiens	57-61
28468300-0	2017	Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells.	nobiletin	0-9	steroid receptor RNA activator 1	Homo sapiens	46-49
28468300-0	2017	Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells.	nobiletin	0-9	protein tyrosine kinase 2	Homo sapiens	50-53
28468300-0	2017	Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells.	nobiletin	0-9	signal transducer and activator of transcription 3	Homo sapiens	54-59
28468300-0	2017	Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells.	nobiletin	0-9	paxillin	Homo sapiens	87-90
28468300-9	2017	Electrophoretic mobility shift assay and the ChIP assay showed that nobiletin inhibits STAT3/DNA binding activity and STAT3 binding to a novel binding site of the PXN gene promoter.	nobiletin	68-77	signal transducer and activator of transcription 3	Homo sapiens	87-92
28468300-9	2017	Electrophoretic mobility shift assay and the ChIP assay showed that nobiletin inhibits STAT3/DNA binding activity and STAT3 binding to a novel binding site of the PXN gene promoter.	nobiletin	68-77	signal transducer and activator of transcription 3	Homo sapiens	118-123
28468300-9	2017	Electrophoretic mobility shift assay and the ChIP assay showed that nobiletin inhibits STAT3/DNA binding activity and STAT3 binding to a novel binding site of the PXN gene promoter.	nobiletin	68-77	paxillin	Homo sapiens	163-166
28468300-11	2017	Nobiletin inhibited tumor angiogenesis by regulating Src, FAK, and STAT3 signaling through PXN in ER+ breast cancer cells.	nobiletin	0-9	steroid receptor RNA activator 1	Homo sapiens	53-56
28468300-11	2017	Nobiletin inhibited tumor angiogenesis by regulating Src, FAK, and STAT3 signaling through PXN in ER+ breast cancer cells.	nobiletin	0-9	protein tyrosine kinase 2	Homo sapiens	58-61
28468300-11	2017	Nobiletin inhibited tumor angiogenesis by regulating Src, FAK, and STAT3 signaling through PXN in ER+ breast cancer cells.	nobiletin	0-9	signal transducer and activator of transcription 3	Homo sapiens	67-72
28468300-11	2017	Nobiletin inhibited tumor angiogenesis by regulating Src, FAK, and STAT3 signaling through PXN in ER+ breast cancer cells.	nobiletin	0-9	paxillin	Homo sapiens	91-94
28107678-7	2017	Specifically, dietary NOB significantly reduced the level of iNOS, up-regulated Nrf2-dependent enzymes and profoundly modulated key signaling proteins resulting in decreased cell cycle progression in the colonic tissue of AOM/DSS-treated mice.	nobiletin	22-25	nitric oxide synthase 2, inducible	Mus musculus	61-65
28107678-7	2017	Specifically, dietary NOB significantly reduced the level of iNOS, up-regulated Nrf2-dependent enzymes and profoundly modulated key signaling proteins resulting in decreased cell cycle progression in the colonic tissue of AOM/DSS-treated mice.	nobiletin	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	80-84
28107678-8	2017	Overall, our findings demonstrated that dietary NOB led to the presence of NOB and its metabolites in the colonic tissue, which suppressed colitis-associated colon carcinogenesis via down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression.	nobiletin	48-51	nitric oxide synthase 2, inducible	Mus musculus	199-203
28107678-8	2017	Overall, our findings demonstrated that dietary NOB led to the presence of NOB and its metabolites in the colonic tissue, which suppressed colitis-associated colon carcinogenesis via down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression.	nobiletin	75-78	nitric oxide synthase 2, inducible	Mus musculus	199-203
28152057-6	2017	In addition, continuous application of the polymethoxy flavonoids nobiletin and tangeretin increased the amplitude and lengthened the period of the PER2::LUC rhythm.	nobiletin	66-75	period circadian clock 2	Mus musculus	148-152
28017776-0	2017	Nobiletin inhibits oxidized-LDL mediated expression of Tissue Factor in human endothelial cells through inhibition of NF-kappaB.	nobiletin	0-9	coagulation factor III, tissue factor	Homo sapiens	55-68
28017776-0	2017	Nobiletin inhibits oxidized-LDL mediated expression of Tissue Factor in human endothelial cells through inhibition of NF-kappaB.	nobiletin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	118-127
28017776-7	2017	This study investigates whether nobiletin might exert protective cardiovascular effects by preventing the oxidized-LDL mediated expression of TF in human endothelial cells in vitro.	nobiletin	32-41	coagulation factor III, tissue factor	Homo sapiens	142-144
28017776-10	2017	Nobiletin prevented these ox-LDL-mediated effects by exerting antioxidant effects, finally leading to inhibition of the transcription factor NF-kappaB.	nobiletin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	141-150
28152057-7	2017	The nobiletin-induced phase delay was blocked by co-treatment with U0126, an ERK inhibitor.	nobiletin	4-13	mitogen-activated protein kinase 1	Mus musculus	77-80
27959381-8	2017	Furthermore, the nobiletin-induced VASP phosphorylation was surprisingly reversed by the intracellular antioxidant, N-acetylcysteine (NAC), but not by the inhibitor of NADPH oxidase, diphenyleneiodonium chloride (DPI).	nobiletin	17-26	vasodilator stimulated phosphoprotein	Homo sapiens	35-39
28700997-8	2017	In addition, NOB supplementation blunted the increased expression of NAPDH oxidase (NOX) 2 and NOX4 and mitigated endoplasmic reticulum (ER) stress and myocyte apoptosis in cardiac hypertrophy.	nobiletin	13-16	cytochrome b-245 beta chain	Rattus norvegicus	69-90
28700997-8	2017	In addition, NOB supplementation blunted the increased expression of NAPDH oxidase (NOX) 2 and NOX4 and mitigated endoplasmic reticulum (ER) stress and myocyte apoptosis in cardiac hypertrophy.	nobiletin	13-16	NADPH oxidase 4	Rattus norvegicus	95-99
28700997-10	2017	However, our data showed that NOB dramatically inhibited NOX2 expression but not NOX4 in vitro.	nobiletin	30-33	cytochrome b-245 beta chain	Rattus norvegicus	57-61
27959381-0	2017	Nobiletin, a citrus flavonoid, activates vasodilator-stimulated phosphoprotein in human platelets through non-cyclic nucleotide-related mechanisms.	nobiletin	0-9	vasodilator stimulated phosphoprotein	Homo sapiens	41-78
27959381-9	2017	It was surprising to observe the differential effects of nobiletin and NAC on VASP phosphorylation in human platelets, since they both have been reported to have antioxidant properties.	nobiletin	57-66	vasodilator stimulated phosphoprotein	Homo sapiens	78-82
27959381-11	2017	Taken together, our findings suggest that nobiletin induces VASP phosphorylation in human platelets through non-cyclic nucleotide-related mechanisms.	nobiletin	42-51	vasodilator stimulated phosphoprotein	Homo sapiens	60-64
27279123-3	2016	Nobiletin, a polymethoxy citrus flavone, has potent MMP-2 and MMP-9 inhibitory activity in addition to antioxidant activity.	nobiletin	0-9	matrix metallopeptidase 2	Rattus norvegicus	52-57
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	cAMP responsive element binding protein 1	Rattus norvegicus	75-114
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	cAMP responsive element binding protein 1	Rattus norvegicus	116-120
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	brain-derived neurotrophic factor	Rattus norvegicus	126-159
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	brain-derived neurotrophic factor	Rattus norvegicus	161-165
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	212-250
27840933-7	2016	Treatment with nobiletin induced the activation of phosphorylated (p)-Akt, p-cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) protein expression and reduced the levels of B-cell lymphoma 2-associated X protein (Bax) in isoflurane-induced rats.	nobiletin	15-24	BCL2 associated X, apoptosis regulator	Rattus norvegicus	252-255
27840933-8	2016	In conclusion, the present study demonstrated that nobiletin may ameliorate isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptotic effects via modulation of Akt, Bax, p-CREB and BDNF in aging rats.	nobiletin	51-60	AKT serine/threonine kinase 1	Rattus norvegicus	200-203
27840933-8	2016	In conclusion, the present study demonstrated that nobiletin may ameliorate isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptotic effects via modulation of Akt, Bax, p-CREB and BDNF in aging rats.	nobiletin	51-60	BCL2 associated X, apoptosis regulator	Rattus norvegicus	205-208
27840933-8	2016	In conclusion, the present study demonstrated that nobiletin may ameliorate isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptotic effects via modulation of Akt, Bax, p-CREB and BDNF in aging rats.	nobiletin	51-60	cAMP responsive element binding protein 1	Rattus norvegicus	212-216
27840933-8	2016	In conclusion, the present study demonstrated that nobiletin may ameliorate isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptotic effects via modulation of Akt, Bax, p-CREB and BDNF in aging rats.	nobiletin	51-60	brain-derived neurotrophic factor	Rattus norvegicus	221-225
27878238-0	2016	Nobiletin attenuates lipopolysaccharide/D-galactosamine-induced liver injury in mice by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-kappaB-mediated cytokine production.	nobiletin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
27878238-6	2016	Treatment with nobiletin reduced serum alanine aminotransferase and aspartate aminotransferase levels, improved hepatic structure, and suppressed hepatic interleukin (IL)-1beta, IL-6 and tumor necrosis factor-alpha production 24 h after LPS/GalN exposure.	nobiletin	15-24	interleukin 6	Mus musculus	178-214
27878238-7	2016	Western blot analysis revealed that nobiletin treatment inhibited inducible nitric oxide synthase and cyclooxygenase-2 liver expression.	nobiletin	36-45	prostaglandin-endoperoxide synthase 2	Mus musculus	102-118
27878238-8	2016	In addition, nobiletin suppressed LPS/GalN-induced phosphorylation and degradation of inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha, as well as NF-kappaB p65 translocation into the nucleus.	nobiletin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-125
27878238-8	2016	In addition, nobiletin suppressed LPS/GalN-induced phosphorylation and degradation of inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha, as well as NF-kappaB p65 translocation into the nucleus.	nobiletin	13-22	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	127-140
27878238-8	2016	In addition, nobiletin suppressed LPS/GalN-induced phosphorylation and degradation of inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha, as well as NF-kappaB p65 translocation into the nucleus.	nobiletin	13-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	163-166
27878238-9	2016	Nobiletin also upregulated the expression of nuclear NF-E2-related factor 2 (Nrf2) and cytoplasmic heme oxygenase-1.	nobiletin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-75
27878238-9	2016	Nobiletin also upregulated the expression of nuclear NF-E2-related factor 2 (Nrf2) and cytoplasmic heme oxygenase-1.	nobiletin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
27878238-9	2016	Nobiletin also upregulated the expression of nuclear NF-E2-related factor 2 (Nrf2) and cytoplasmic heme oxygenase-1.	nobiletin	0-9	heme oxygenase 1	Mus musculus	99-115
27279123-3	2016	Nobiletin, a polymethoxy citrus flavone, has potent MMP-2 and MMP-9 inhibitory activity in addition to antioxidant activity.	nobiletin	0-9	matrix metallopeptidase 9	Rattus norvegicus	62-67
27279123-4	2016	We hypothesized that nobiletin due to its MMP-2 & MMP-9 inhibitory and antioxidant effects may ameliorate the cardiovascular dysfunction of diabetes.	nobiletin	21-30	matrix metallopeptidase 2	Rattus norvegicus	42-47
27279123-4	2016	We hypothesized that nobiletin due to its MMP-2 & MMP-9 inhibitory and antioxidant effects may ameliorate the cardiovascular dysfunction of diabetes.	nobiletin	21-30	matrix metallopeptidase 9	Rattus norvegicus	54-59
27279123-10	2016	Treatment with 25 mg kg(-1) nobiletin ameliorated the hemodynamic parameters, oxidative stress, collagen level, MMP-2 and MMP-9 levels, and vascular reactivity significantly compared with vehicle treated diabetic group.	nobiletin	28-37	matrix metallopeptidase 2	Rattus norvegicus	112-117
27279123-10	2016	Treatment with 25 mg kg(-1) nobiletin ameliorated the hemodynamic parameters, oxidative stress, collagen level, MMP-2 and MMP-9 levels, and vascular reactivity significantly compared with vehicle treated diabetic group.	nobiletin	28-37	matrix metallopeptidase 9	Rattus norvegicus	122-127
27279123-11	2016	Thus, this study suggests that nobiletin ameliorates the CVD of diabetes by inhibiting oxidative stress, MMP-2 & MMP-9 and can be used as a potential therapeutic approach.	nobiletin	31-40	matrix metallopeptidase 2	Rattus norvegicus	105-110
27279123-11	2016	Thus, this study suggests that nobiletin ameliorates the CVD of diabetes by inhibiting oxidative stress, MMP-2 & MMP-9 and can be used as a potential therapeutic approach.	nobiletin	31-40	matrix metallopeptidase 9	Rattus norvegicus	117-122
27261583-0	2016	Nobiletin protects against murine l-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT.	nobiletin	0-9	mitogen-activated protein kinase 14	Mus musculus	107-110
27261583-0	2016	Nobiletin protects against murine l-arginine-induced acute pancreatitis in association with downregulating p38MAPK and AKT.	nobiletin	0-9	thymoma viral proto-oncogene 1	Mus musculus	119-122
27261583-6	2016	The nobiletin treatment significantly reduced the plasma amylase levels, pancreatic myeloperoxidase activity, percentage of pancreatic necrosis, plasma proinflammatory factors, the generation of reactive oxygen species, cell apoptosis, tissue damage, and the expression of phosphorylated p38MAPK (p-p38MAPK) and p-AKT.	nobiletin	4-13	myeloperoxidase	Mus musculus	84-99
27261583-6	2016	The nobiletin treatment significantly reduced the plasma amylase levels, pancreatic myeloperoxidase activity, percentage of pancreatic necrosis, plasma proinflammatory factors, the generation of reactive oxygen species, cell apoptosis, tissue damage, and the expression of phosphorylated p38MAPK (p-p38MAPK) and p-AKT.	nobiletin	4-13	mitogen-activated protein kinase 14	Mus musculus	288-295
27261583-6	2016	The nobiletin treatment significantly reduced the plasma amylase levels, pancreatic myeloperoxidase activity, percentage of pancreatic necrosis, plasma proinflammatory factors, the generation of reactive oxygen species, cell apoptosis, tissue damage, and the expression of phosphorylated p38MAPK (p-p38MAPK) and p-AKT.	nobiletin	4-13	mitogen-activated protein kinase 14	Mus musculus	299-306
27261583-6	2016	The nobiletin treatment significantly reduced the plasma amylase levels, pancreatic myeloperoxidase activity, percentage of pancreatic necrosis, plasma proinflammatory factors, the generation of reactive oxygen species, cell apoptosis, tissue damage, and the expression of phosphorylated p38MAPK (p-p38MAPK) and p-AKT.	nobiletin	4-13	thymoma viral proto-oncogene 1	Mus musculus	314-317
27128150-3	2016	Nobiletin activated the cAMP/PKA/MEK/Erk/MAPK signaling pathway without using the TrkA signaling activated by nerve growth factor (NGF).	nobiletin	0-9	Eph receptor B1	Rattus norvegicus	37-40
27988519-0	2016	Nobiletin Relaxes Isolated Mesenteric Arteries by Activating the Endothelial Ca2+-eNOS Pathway in Rats.	nobiletin	0-9	nitric oxide synthase 3	Rattus norvegicus	82-86
27144433-0	2016	Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression.	nobiletin	0-9	mitogen-activated protein kinase 1	Homo sapiens	67-70
27144433-0	2016	Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression.	nobiletin	0-9	mitogen-activated protein kinase 8	Homo sapiens	75-78
27144433-0	2016	Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression.	nobiletin	0-9	matrix metallopeptidase 2	Homo sapiens	88-92
27144433-4	2016	Nobiletin, up to 100 muM without cytotoxicity, significantly decreased motility, migration and invasion as well as enzymatic activities, protein levels and mRNA expressions of matrix metalloproteinase (MMP)-2 and MMP-9 in U2OS and HOS cells.	nobiletin	0-9	matrix metallopeptidase 2	Homo sapiens	176-208
27144433-4	2016	Nobiletin, up to 100 muM without cytotoxicity, significantly decreased motility, migration and invasion as well as enzymatic activities, protein levels and mRNA expressions of matrix metalloproteinase (MMP)-2 and MMP-9 in U2OS and HOS cells.	nobiletin	0-9	matrix metallopeptidase 9	Homo sapiens	213-218
27144433-5	2016	In addition to inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), the inhibitory effect of nobiletin on the DNA-binding activity of the transcription factor nuclear factor-kappa B (NF-kappaB), cAMP response element-binding protein (CREB), and specificity protein 1 (SP-1) in U2OS and HOS cells.	nobiletin	133-142	nuclear factor kappa B subunit 1	Homo sapiens	199-221
27144433-5	2016	In addition to inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), the inhibitory effect of nobiletin on the DNA-binding activity of the transcription factor nuclear factor-kappa B (NF-kappaB), cAMP response element-binding protein (CREB), and specificity protein 1 (SP-1) in U2OS and HOS cells.	nobiletin	133-142	nuclear factor kappa B subunit 1	Homo sapiens	223-232
27144433-5	2016	In addition to inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), the inhibitory effect of nobiletin on the DNA-binding activity of the transcription factor nuclear factor-kappa B (NF-kappaB), cAMP response element-binding protein (CREB), and specificity protein 1 (SP-1) in U2OS and HOS cells.	nobiletin	133-142	cAMP responsive element binding protein 1	Homo sapiens	235-272
27144433-5	2016	In addition to inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), the inhibitory effect of nobiletin on the DNA-binding activity of the transcription factor nuclear factor-kappa B (NF-kappaB), cAMP response element-binding protein (CREB), and specificity protein 1 (SP-1) in U2OS and HOS cells.	nobiletin	133-142	cAMP responsive element binding protein 1	Homo sapiens	274-278
27144433-5	2016	In addition to inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), the inhibitory effect of nobiletin on the DNA-binding activity of the transcription factor nuclear factor-kappa B (NF-kappaB), cAMP response element-binding protein (CREB), and specificity protein 1 (SP-1) in U2OS and HOS cells.	nobiletin	133-142	Sp1 transcription factor	Homo sapiens	285-306
27144433-7	2016	These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-kappaB, CREB, and SP-1.	nobiletin	29-38	matrix metallopeptidase 2	Homo sapiens	138-143
27144433-7	2016	These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-kappaB, CREB, and SP-1.	nobiletin	29-38	matrix metallopeptidase 9	Homo sapiens	148-153
27144433-7	2016	These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-kappaB, CREB, and SP-1.	nobiletin	29-38	mitogen-activated protein kinase 1	Homo sapiens	170-173
27144433-7	2016	These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-kappaB, CREB, and SP-1.	nobiletin	29-38	mitogen-activated protein kinase 8	Homo sapiens	178-181
27144433-7	2016	These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-kappaB, CREB, and SP-1.	nobiletin	29-38	nuclear factor kappa B subunit 1	Homo sapiens	234-243
27144433-7	2016	These results indicated that nobiletin inhibits human osteosarcoma U2OS and HOS cells motility, migration and invasion by down-regulating MMP-2 and MMP-9 expressions via ERK and JNK pathways and through the inactivation of downstream NF-kappaB, CREB, and SP-1.	nobiletin	29-38	cAMP responsive element binding protein 1	Homo sapiens	245-249
27160937-6	2016	Nobiletin treatment also blunted the mRNA expression of NADPH oxidase isoforms p67(phox), p22(phox), and p91(phox), and abated oxidative stress.	nobiletin	0-9	methionine aminopeptidase 2	Mus musculus	79-82
27160937-6	2016	Nobiletin treatment also blunted the mRNA expression of NADPH oxidase isoforms p67(phox), p22(phox), and p91(phox), and abated oxidative stress.	nobiletin	0-9	dynein cytoplasmic 1 heavy chain 1	Mus musculus	90-93
27160937-7	2016	Although administration of diabetic mice with nobiletin did not significantly effect the level of blood glucose, it decreased the TGF-beta1, CTGF, fibronectin, and collagen Ialpha expressions and blunted cardiac fibrosis.	nobiletin	46-55	transforming growth factor, beta 1	Mus musculus	130-139
27160937-7	2016	Although administration of diabetic mice with nobiletin did not significantly effect the level of blood glucose, it decreased the TGF-beta1, CTGF, fibronectin, and collagen Ialpha expressions and blunted cardiac fibrosis.	nobiletin	46-55	cellular communication network factor 2	Mus musculus	141-145
27160937-7	2016	Although administration of diabetic mice with nobiletin did not significantly effect the level of blood glucose, it decreased the TGF-beta1, CTGF, fibronectin, and collagen Ialpha expressions and blunted cardiac fibrosis.	nobiletin	46-55	fibronectin 1	Mus musculus	147-158
27160937-8	2016	In addition, nobiletin inhibited the activation of c-Jun NH2-terminal kinase (JNK), P38, and NF-kappaB in the cardiac tissue of diabetic mice.	nobiletin	13-22	mitogen-activated protein kinase 8	Mus musculus	51-76
27160937-8	2016	In addition, nobiletin inhibited the activation of c-Jun NH2-terminal kinase (JNK), P38, and NF-kappaB in the cardiac tissue of diabetic mice.	nobiletin	13-22	mitogen-activated protein kinase 8	Mus musculus	78-81
27160937-8	2016	In addition, nobiletin inhibited the activation of c-Jun NH2-terminal kinase (JNK), P38, and NF-kappaB in the cardiac tissue of diabetic mice.	nobiletin	13-22	mitogen-activated protein kinase 14	Mus musculus	84-87
27160937-9	2016	Collectively, our study indicates that treatment with nobiletin mitigates cardiac dysfunction and interstitial fibrosis, and these beneficial of nobiletin may belong to the suppression of JNK, P38, and NF-kappaB signaling pathways.	nobiletin	145-154	mitogen-activated protein kinase 8	Mus musculus	188-191
27160937-9	2016	Collectively, our study indicates that treatment with nobiletin mitigates cardiac dysfunction and interstitial fibrosis, and these beneficial of nobiletin may belong to the suppression of JNK, P38, and NF-kappaB signaling pathways.	nobiletin	145-154	mitogen-activated protein kinase 14	Mus musculus	193-196
26986176-0	2016	Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-beta1/Smad3 signaling pathway.	nobiletin	0-9	transforming growth factor beta 1	Homo sapiens	115-124
26986176-0	2016	Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-beta1/Smad3 signaling pathway.	nobiletin	0-9	SMAD family member 3	Homo sapiens	125-130
26986176-4	2016	In the present study, lung adenocarcinoma A549 and H1299 cells were used to evaluate the effect of nobiletin on EMT induced by TGF-beta1.	nobiletin	99-108	transforming growth factor beta 1	Homo sapiens	127-136
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	transforming growth factor beta 1	Homo sapiens	33-42
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	matrix metallopeptidase 2	Homo sapiens	129-134
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	matrix metallopeptidase 9	Homo sapiens	136-141
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	snail family transcriptional repressor 1	Homo sapiens	169-174
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	snail family transcriptional repressor 2	Homo sapiens	176-180
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	twist family bHLH transcription factor 1	Homo sapiens	182-187
26986176-5	2016	Nobiletin successfully inhibited TGF-beta1-induced EMT, migration, invasion and adhesion in vitro, accompanied by attenuation of MMP-2, MMP-9, p-Src, p-FAK, p-paxillin, Snail, Slug, Twist and ZEB1 expression.	nobiletin	0-9	zinc finger E-box binding homeobox 1	Homo sapiens	192-196
26878777-4	2016	Nobiletin (10-30muM) inhibited collagen- and arachidonic acid-induced platelet aggregation in washed human platelets, but it did not inhibit platelet aggregation induced by other agonists such as thrombin and 9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin.	nobiletin	0-9	latexin	Homo sapiens	16-19
26878777-5	2016	Nobiletin inhibited the phosphorylation of phospholipase PLCgamma2, protein kinase PKC, Akt and mitogen-activated protein kinase MAPKs in collagen-activated human platelets and markedly reduced intracellular calcium mobilization and hydroxyl radical (OH( )) formation.	nobiletin	0-9	phospholipase C gamma 2	Homo sapiens	57-66
26878777-5	2016	Nobiletin inhibited the phosphorylation of phospholipase PLCgamma2, protein kinase PKC, Akt and mitogen-activated protein kinase MAPKs in collagen-activated human platelets and markedly reduced intracellular calcium mobilization and hydroxyl radical (OH( )) formation.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	88-91
26878777-9	2016	In conclusion, this study demonstrates for the first time that, in addition to being a potential agent for preventing tumor growth and inflammation, nobiletin exhibits potent antiplatelet activity, which initially inhibits the PLCgamma2/PKC cascade and hydroxyl radical formation, subsequently suppresses the activation of Akt and MAPKs and ultimately inhibits platelet activation.	nobiletin	149-158	phospholipase C gamma 2	Homo sapiens	227-236
26878777-9	2016	In conclusion, this study demonstrates for the first time that, in addition to being a potential agent for preventing tumor growth and inflammation, nobiletin exhibits potent antiplatelet activity, which initially inhibits the PLCgamma2/PKC cascade and hydroxyl radical formation, subsequently suppresses the activation of Akt and MAPKs and ultimately inhibits platelet activation.	nobiletin	149-158	AKT serine/threonine kinase 1	Homo sapiens	323-326
26560814-0	2016	Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways.	nobiletin	0-9	AKT serine/threonine kinase 1	Homo sapiens	131-134
26560814-7	2016	Altogether, the present results suggest that nobiletin inhibits mitogen-activated protein kinase and Akt/protein kinase B pathways and downregulates positive regulators of the cell cycle, leading to subsequent suppression of glioma cell proliferation and migration.	nobiletin	45-54	AKT serine/threonine kinase 1	Homo sapiens	101-104
26560814-7	2016	Altogether, the present results suggest that nobiletin inhibits mitogen-activated protein kinase and Akt/protein kinase B pathways and downregulates positive regulators of the cell cycle, leading to subsequent suppression of glioma cell proliferation and migration.	nobiletin	45-54	protein tyrosine kinase 2 beta	Homo sapiens	105-121
27076076-2	2016	In an unbiased chemical screen using fibroblasts expressing PER2::Luc, we identified Nobiletin (NOB), a natural polymethoxylated flavone, as a clock amplitude-enhancing small molecule.	nobiletin	85-94	period circadian clock 2	Mus musculus	60-64
26874072-12	2016	CONCLUSION: NOB may have a neuroprotective effect on cerebral ischemia, and this protection may be through upregulating Nrf2, HO-1 and downregulating NF-kappaB expression.	nobiletin	12-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
26874072-12	2016	CONCLUSION: NOB may have a neuroprotective effect on cerebral ischemia, and this protection may be through upregulating Nrf2, HO-1 and downregulating NF-kappaB expression.	nobiletin	12-15	heme oxygenase 1	Rattus norvegicus	126-130
26846885-0	2016	Protective Effects of Nobiletin Against Endotoxic Shock in Mice Through Inhibiting TNF-alpha, IL-6, and HMGB1 and Regulating NF-kappaB Pathway.	nobiletin	22-31	tumor necrosis factor	Mus musculus	83-92
26846885-0	2016	Protective Effects of Nobiletin Against Endotoxic Shock in Mice Through Inhibiting TNF-alpha, IL-6, and HMGB1 and Regulating NF-kappaB Pathway.	nobiletin	22-31	interleukin 6	Mus musculus	94-98
26846885-0	2016	Protective Effects of Nobiletin Against Endotoxic Shock in Mice Through Inhibiting TNF-alpha, IL-6, and HMGB1 and Regulating NF-kappaB Pathway.	nobiletin	22-31	high mobility group box 1	Mus musculus	104-109
26846885-0	2016	Protective Effects of Nobiletin Against Endotoxic Shock in Mice Through Inhibiting TNF-alpha, IL-6, and HMGB1 and Regulating NF-kappaB Pathway.	nobiletin	22-31	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
26846885-4	2016	The present study clearly demonstrates that pretreatment with NOB decreases the production of early pro-inflammatory cytokines TNF-alpha, IL-6, and late-phase mediator HMGB1 in serum and tissues of kidney, lung, and liver.	nobiletin	62-65	tumor necrosis factor	Mus musculus	127-136
26846885-4	2016	The present study clearly demonstrates that pretreatment with NOB decreases the production of early pro-inflammatory cytokines TNF-alpha, IL-6, and late-phase mediator HMGB1 in serum and tissues of kidney, lung, and liver.	nobiletin	62-65	interleukin 6	Mus musculus	138-142
26846885-4	2016	The present study clearly demonstrates that pretreatment with NOB decreases the production of early pro-inflammatory cytokines TNF-alpha, IL-6, and late-phase mediator HMGB1 in serum and tissues of kidney, lung, and liver.	nobiletin	62-65	high mobility group box 1	Mus musculus	168-173
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	27-30	tumor necrosis factor	Mus musculus	118-127
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	27-30	interleukin 6	Mus musculus	129-133
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	27-30	high mobility group box 1	Mus musculus	139-144
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-176
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	199-202	tumor necrosis factor	Mus musculus	118-127
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	199-202	interleukin 6	Mus musculus	129-133
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	199-202	high mobility group box 1	Mus musculus	139-144
26846885-7	2016	These results suggest that NOB protects mice against LPS-induced endotoxic shock through inhibiting the production of TNF-alpha, IL-6, and HMGB1 and the activation of NF-kappaB, which elucidate that NOB may be a promising drug candidate for the treatment of septic shock.	nobiletin	199-202	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	167-176
26689156-0	2015	Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells.	nobiletin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	62-67
26689156-2	2015	Here we found that nobiletin, a citrus methoxyflavone, significantly sensitized ABCB1 overexpressing cells A2780/T and A549/T to chemotherapeutic agents such as paclitaxel (a 433-fold reversal of MDR to PTX at 9 muM), doxorubicin (DOX), docetaxel and dounorubicin.	nobiletin	19-28	ATP binding cassette subfamily B member 1	Homo sapiens	80-85
26689156-3	2015	Nobiletin profoundly inhibited ABCB1 transporter activity since it significantly increased the intracellular accumulation of DOX and Flutax-2 in A2780/T cells and decreased the efflux of ABCB1 substrates in Caco2 cells without altering the mRNA and protein expression of ABCB1.	nobiletin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	31-36
26689156-3	2015	Nobiletin profoundly inhibited ABCB1 transporter activity since it significantly increased the intracellular accumulation of DOX and Flutax-2 in A2780/T cells and decreased the efflux of ABCB1 substrates in Caco2 cells without altering the mRNA and protein expression of ABCB1.	nobiletin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	187-192
26689156-3	2015	Nobiletin profoundly inhibited ABCB1 transporter activity since it significantly increased the intracellular accumulation of DOX and Flutax-2 in A2780/T cells and decreased the efflux of ABCB1 substrates in Caco2 cells without altering the mRNA and protein expression of ABCB1.	nobiletin	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	187-192
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	111-120	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	111-120	AKT serine/threonine kinase 1	Homo sapiens	68-71
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	111-120	mitogen-activated protein kinase 1	Homo sapiens	72-75
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	111-120	AKT serine/threonine kinase 1	Homo sapiens	195-198
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	111-120	mitogen-activated protein kinase 1	Homo sapiens	199-202
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	111-120	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	262-271	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	262-271	AKT serine/threonine kinase 1	Homo sapiens	68-71
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	262-271	mitogen-activated protein kinase 1	Homo sapiens	72-75
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	262-271	AKT serine/threonine kinase 1	Homo sapiens	195-198
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	262-271	mitogen-activated protein kinase 1	Homo sapiens	199-202
26689156-6	2015	Moreover, the Nrf2 protein expression and phosphorylation levels of AKT/ERK were suppressed by co-treated with nobiletin and PTX at the reversal concentrations, suggesting that inhibition of the AKT/ERK/Nrf2 pathway was associated with the sensitizing effect of nobiletin.	nobiletin	262-271	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
27988519-7	2016	Nobiletin increased NO production by promoting the phosphorylation of eNOS at Ser-1177 without changing the level of eNOS expression in rat mesenteric artery endothelial cells (RMAECs).	nobiletin	0-9	nitric oxide synthase 3	Rattus norvegicus	70-74
27988519-8	2016	Nobiletin increased the concentration of endothelial [Ca2+]i, which enhances eNOS activity in RMAECs.	nobiletin	0-9	nitric oxide synthase 3	Rattus norvegicus	77-81
27988519-9	2016	In summary, vasodilation induced by nobiletin was dependent on the endothelium and partly on eNOS activation, which is mediated by high endothelial [Ca2+]i.	nobiletin	36-45	nitric oxide synthase 3	Rattus norvegicus	93-97
25913833-3	2015	Our recent studies have demonstrated that nobiletin, a polymethoxylated flavone from citrus peels, ameliorates learning and memory impairment in olfactory-bulbectomized mice, amyloid precursor protein transgenic mice, NMDA receptor antagonist-treated mice, and senescence-accelerated mouse prone 8.	nobiletin	42-51	amyloid beta (A4) precursor protein	Mus musculus	175-200
25655748-9	2015	PI3K inhibitor or siRNA targeting of either Akt or NF-kappaB mitigated the impact of nobiletin on MLCK expression and barrier function in Caco-2 monolayer, respectively.	nobiletin	85-94	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
26075008-8	2015	A circadian clock-deficient mouse mutant, Clock (Delta19/Delta19) , was utilized to examine a requisite role of the circadian clock in mediating NOB induction of Cps1.	nobiletin	145-148	carbamoyl-phosphate synthetase 1	Mus musculus	162-166
25988959-9	2015	Nobiletin extended bleeding time in mice and reduced the phosphorylation of PKB (Akt) and PLCgamma2 within the collagen receptor (glycoprotein VI)-stimulated pathway, in addition to increasing the levels of cGMP and phosphorylation of vasodilator-stimulated phosphoprotein, a protein whose activity is associated with inhibitory cyclic nucleotide signalling.	nobiletin	0-9	phospholipase C, gamma 2	Mus musculus	90-99
25655748-9	2015	PI3K inhibitor or siRNA targeting of either Akt or NF-kappaB mitigated the impact of nobiletin on MLCK expression and barrier function in Caco-2 monolayer, respectively.	nobiletin	85-94	myosin light chain kinase	Rattus norvegicus	98-102
25655748-10	2015	CONCLUSION: Nobiletin exerted anti-inflammatory effects in TNBS-induced colitis through the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expression.	nobiletin	12-21	nitric oxide synthase 2	Rattus norvegicus	110-141
25655748-10	2015	CONCLUSION: Nobiletin exerted anti-inflammatory effects in TNBS-induced colitis through the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expression.	nobiletin	12-21	nitric oxide synthase 2	Rattus norvegicus	143-147
25655748-10	2015	CONCLUSION: Nobiletin exerted anti-inflammatory effects in TNBS-induced colitis through the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expression.	nobiletin	12-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	153-169
25655748-10	2015	CONCLUSION: Nobiletin exerted anti-inflammatory effects in TNBS-induced colitis through the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) expression.	nobiletin	12-21	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	171-176
25655748-11	2015	Nobiletin restored barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-kappaB-MLCK pathway.	nobiletin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	117-120
25655748-11	2015	Nobiletin restored barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt-NF-kappaB-MLCK pathway.	nobiletin	0-9	myosin light chain kinase	Rattus norvegicus	131-135