PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33639197-0 2021 Incorporating renal excretion via the OCT2 transporter in physiologically based kinetic modelling to predict in vivo kinetics of mepiquat in rat. mepiquat 129-137 solute carrier family 22 member 2 Rattus norvegicus 38-42 33639197-2 2021 The Vmax (10.5 pmol/min/mg protein) and Km (20.6 muM) of OCT2 transport of MQ were determined by concentration-dependent uptake in SA7K cells using doxepin as inhibitor. mepiquat 75-77 solute carrier family 22 member 2 Homo sapiens 57-61 33639197-4 2021 Applying an overall scaling factor that also corrects for potential differences in OCT2 activity in the SA7K cells and in vivo kidney cortex and species differences resulted in adequate predictions for in vivo kinetics of MQ in rat (2.3-3.2-fold). mepiquat 222-224 solute carrier family 22 member 2 Rattus norvegicus 83-87 28082810-8 2016 However, when CFTR Cl- channel was blocked by 1,1-dimethyl piperidinium chloride (DPC), 5-HT-induced Isc did not significantly differ in three groups (42.28 microA/cm2 +- 10.61 microA/cm2vs 51.48 microA/cm2 +- 6.56 microA/cm2vs 47.75 microA/cm2 +- 7.99 microA/cm2, P > 0.05, respectively). mepiquat 46-80 CF transmembrane conductance regulator Rattus norvegicus 14-18 28082810-8 2016 However, when CFTR Cl- channel was blocked by 1,1-dimethyl piperidinium chloride (DPC), 5-HT-induced Isc did not significantly differ in three groups (42.28 microA/cm2 +- 10.61 microA/cm2vs 51.48 microA/cm2 +- 6.56 microA/cm2vs 47.75 microA/cm2 +- 7.99 microA/cm2, P > 0.05, respectively). mepiquat 82-85 CF transmembrane conductance regulator Rattus norvegicus 14-18 25017155-4 2014 The MC significantly decreased endogenous GA3 and GA4 levels in the elongating internode, which inhibited cell elongation by downregulating GhEXP and GhXTH2, and then reducing plant height. mepiquat 4-6 probable xyloglucan endotransglucosylase/hydrolase protein 6 Gossypium hirsutum 150-156