PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33443775-0 2021 Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. corosolic acid 0-14 erb-b2 receptor tyrosine kinase 2 Homo sapiens 66-70 33443775-0 2021 Corosolic acid inhibits colorectal cancer cells growth as a novel HER2/HER3 heterodimerization inhibitor. corosolic acid 0-14 erb-b2 receptor tyrosine kinase 3 Homo sapiens 71-75 32220262-0 2020 Corosolic Acid Inhibits Cancer Progress Through Inactivating YAP in Hepatocellular Carcinoma. corosolic acid 0-14 yes-associated protein 1 Mus musculus 61-64 32135139-0 2020 Triterpenoid corosolic acid modulates global CpG methylation and transcriptome of tumor promotor TPA induced mouse epidermal JB6 P+ cells. corosolic acid 13-27 promotion susceptibility QTL 1 Mus musculus 97-100 32733256-0 2020 Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems. corosolic acid 20-34 ubiquitin associated domain containing 1 Mus musculus 40-45 32733256-0 2020 Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems. corosolic acid 20-34 ubiquitin associated domain containing 1 Mus musculus 93-98 32733256-3 2020 Using enzyme inhibition assays, checkerboard MIC assays, growth curves, time-killing assays and combined disk test, we found that the natural compound corosolic acid (CA) significantly inhibited the activity of the class A beta-lactamase KPC-2, which is common among clinical isolates. corosolic acid 151-165 ubiquitin associated domain containing 1 Mus musculus 238-243 32135139-8 2020 Novel TPA induced differentially overexpressed genes like tumor promoter Prl2c2, small prolin rich protein (Sprr2h) was reported which was downregulated by corosolic acid treatment. corosolic acid 156-170 plasminogen activator, tissue type Homo sapiens 6-9 32135139-11 2020 Interestingly, genes like CDK1 (Cyclin-dependent kinases 1) and RASSF2 (Ras association domain family member 2) observed to be differentially methylated and expressed which was further modulated by corosolic acid treatment, validated by qPCR. corosolic acid 198-212 cyclin dependent kinase 1 Homo sapiens 26-30 32135139-11 2020 Interestingly, genes like CDK1 (Cyclin-dependent kinases 1) and RASSF2 (Ras association domain family member 2) observed to be differentially methylated and expressed which was further modulated by corosolic acid treatment, validated by qPCR. corosolic acid 198-212 cyclin dependent kinase 1 Homo sapiens 32-58 32135139-11 2020 Interestingly, genes like CDK1 (Cyclin-dependent kinases 1) and RASSF2 (Ras association domain family member 2) observed to be differentially methylated and expressed which was further modulated by corosolic acid treatment, validated by qPCR. corosolic acid 198-212 Ras association domain family member 2 Homo sapiens 64-70 32135139-11 2020 Interestingly, genes like CDK1 (Cyclin-dependent kinases 1) and RASSF2 (Ras association domain family member 2) observed to be differentially methylated and expressed which was further modulated by corosolic acid treatment, validated by qPCR. corosolic acid 198-212 Ras association domain family member 2 Homo sapiens 72-110 31150656-13 2019 Taken together, these results demonstrated that CRA has good absorption in both stomach and small intestine, but it could be metabolized partly due to CYP1A2 and CYP3A4 in vivo. corosolic acid 48-51 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 151-157 32329643-0 2020 Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-kappaB/MAPK Signaling Pathways. corosolic acid 0-14 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 83-87 32329643-0 2020 Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-kappaB/MAPK Signaling Pathways. corosolic acid 0-14 nuclear factor kappa B subunit 1 Homo sapiens 99-108 31206698-0 2019 Inhibitory effect of corosolic acid on alpha-glucosidase: kinetics, interaction mechanism, and molecular simulation. corosolic acid 21-35 sucrase-isomaltase Homo sapiens 39-56 31206698-4 2019 RESULTS: Corosolic acid significantly inhibited alpha-glucosidase reversibly in an uncompetitive manner and its IC50 value was 1.35 x 10-5 mol L-1 . corosolic acid 9-23 sucrase-isomaltase Homo sapiens 48-65 31206698-8 2019 CONCLUSIONS: These results may suggest new insights into corosolic acid from food sources as a potential alpha-glucosidase inhibitor that could better control diabetes. corosolic acid 57-71 sucrase-isomaltase Homo sapiens 105-122 32081779-1 2020 Corosolic acid (CA), a natural pentacyclic triterpenoid, exhibits antitumor and synergistic therapy effect with chemotherapeutic drugs mainly through inhibiting STAT3 activation. corosolic acid 0-14 signal transducer and activator of transcription 3 Mus musculus 161-166 32120080-0 2020 Semi-synthesis of C28-modified triterpene acid derivatives from maslinic acid or corosolic acid as potential alpha-glucosidase inhibitors. corosolic acid 81-95 sucrase-isomaltase Homo sapiens 109-126 31150656-13 2019 Taken together, these results demonstrated that CRA has good absorption in both stomach and small intestine, but it could be metabolized partly due to CYP1A2 and CYP3A4 in vivo. corosolic acid 48-51 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 162-168 30453049-0 2019 Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress. corosolic acid 58-72 mitogen-activated protein kinase 8 Mus musculus 14-17 30898728-0 2019 Triterpenoid corosolic acid attenuates HIF-1 stabilization upon cobalt (II) chloride-induced hypoxia in A549 human lung epithelial cancer cells. corosolic acid 13-27 hypoxia inducible factor 1 subunit alpha Homo sapiens 39-44 30637473-0 2019 STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes. corosolic acid 83-97 signal transducer and activator of transcription 3 Homo sapiens 0-5 30637473-0 2019 STAT3 inhibition specifically in human monocytes and macrophages by CD163-targeted corosolic acid-containing liposomes. corosolic acid 83-97 CD163 molecule Homo sapiens 68-73 30637473-5 2019 Here, we report the first data on a CD163-targeted STAT3-inhibitory drug consisting of corosolic acid (CA) packaged within long-circulating liposomes (LCLs), which are CD163-targeted by modification with monoclonal anti-CD163 antibodies (alphaCD163)-CA-LCL-alphaCD163. corosolic acid 87-101 CD163 molecule Homo sapiens 36-41 30637473-5 2019 Here, we report the first data on a CD163-targeted STAT3-inhibitory drug consisting of corosolic acid (CA) packaged within long-circulating liposomes (LCLs), which are CD163-targeted by modification with monoclonal anti-CD163 antibodies (alphaCD163)-CA-LCL-alphaCD163. corosolic acid 87-101 signal transducer and activator of transcription 3 Homo sapiens 51-56 30637473-5 2019 Here, we report the first data on a CD163-targeted STAT3-inhibitory drug consisting of corosolic acid (CA) packaged within long-circulating liposomes (LCLs), which are CD163-targeted by modification with monoclonal anti-CD163 antibodies (alphaCD163)-CA-LCL-alphaCD163. corosolic acid 87-101 CD163 molecule Homo sapiens 168-173 30637473-5 2019 Here, we report the first data on a CD163-targeted STAT3-inhibitory drug consisting of corosolic acid (CA) packaged within long-circulating liposomes (LCLs), which are CD163-targeted by modification with monoclonal anti-CD163 antibodies (alphaCD163)-CA-LCL-alphaCD163. corosolic acid 87-101 CD163 molecule Homo sapiens 168-173 30453049-0 2019 Inhibition of JNK and activation of the AMPK-Nrf2 axis by corosolic acid suppress osteolysis and oxidative stress. corosolic acid 58-72 nuclear factor, erythroid derived 2, like 2 Mus musculus 45-49 30453049-3 2019 In the current study, it was first demonstrated that RANKL-induced osteoclastogenesis and hydroxylapatite resorption were suppressed by Corosolic acid (CA) via inhibiting p-JNK and activating p-AMPK. corosolic acid 136-150 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 53-58 30453049-3 2019 In the current study, it was first demonstrated that RANKL-induced osteoclastogenesis and hydroxylapatite resorption were suppressed by Corosolic acid (CA) via inhibiting p-JNK and activating p-AMPK. corosolic acid 136-150 mitogen-activated protein kinase 8 Mus musculus 173-176 30176898-0 2018 Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. corosolic acid 0-14 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 148-153 30176898-0 2018 Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. corosolic acid 0-14 mitogen-activated protein kinase 8 Homo sapiens 154-157 30176898-0 2018 Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. corosolic acid 0-14 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 159-163 30176898-0 2018 Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. corosolic acid 0-14 DNA damage inducible transcript 3 Homo sapiens 164-168 30176898-0 2018 Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3. corosolic acid 0-14 tribbles pseudokinase 3 Homo sapiens 173-178 30015846-12 2018 In addition, compound c treatment reversed corosolic acid-induced apoptotic markers such as capase-3 and PARP cleavage, and cytochrome c translocation to cytosol, in the presence of 5-FU. corosolic acid 43-57 poly(ADP-ribose) polymerase 1 Homo sapiens 105-109 29620242-0 2018 Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling. corosolic acid 0-14 maternal embryonic leucine zipper kinase Homo sapiens 113-117 29620242-0 2018 Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling. corosolic acid 0-14 forkhead box M1 Homo sapiens 118-123 29247555-0 2018 The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells. corosolic acid 17-31 nuclear factor, erythroid derived 2, like 2 Mus musculus 85-89 29702597-8 2018 In addition, corosolic acid induces non-apoptotic cell death in other renal cancer (ACHN and A498), breast cancer (MDA-MB231), and hepatocellular carcinoma (SK-Hep1 and Huh7) cells, and &alpha;-tocopherol markedly inhibits corosolic acid-induced cell death. corosolic acid 13-27 DNL-type zinc finger Homo sapiens 160-164 29702597-8 2018 In addition, corosolic acid induces non-apoptotic cell death in other renal cancer (ACHN and A498), breast cancer (MDA-MB231), and hepatocellular carcinoma (SK-Hep1 and Huh7) cells, and &alpha;-tocopherol markedly inhibits corosolic acid-induced cell death. corosolic acid 13-27 MIR7-3 host gene Homo sapiens 169-173 29247555-6 2018 Bisulfite genomic sequencing and methylated DNA immunoprecipitation results revealed that CRA treatment decreased the level of methylation of the first five CpG sites of the Nrf2 promoter. corosolic acid 90-93 nuclear factor, erythroid derived 2, like 2 Mus musculus 174-178 29247555-7 2018 Histone modification was analyzed using a chromatin immunoprecipitation (ChIP) assay, which revealed that CRA treatment increased the acetylation of histone H3 lysine 27 (H3K27ac) while decreasing the trimethylation of histone H3 lysine 27 (H3K27me3) in the promoter region of Nrf2. corosolic acid 106-109 nuclear factor, erythroid derived 2, like 2 Mus musculus 277-281 29247555-0 2018 The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells. corosolic acid 17-31 tumor necrosis factor receptor superfamily, member 25 Mus musculus 93-98 29247555-3 2018 In this study, we investigated the effect of CRA on cellular transformation and the reactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) through epigenetic regulation in TRAMP-C1 prostate cells. corosolic acid 45-48 tumor necrosis factor receptor superfamily, member 25 Mus musculus 184-189 30504678-0 2018 Asiatic Acid, Corosolic Acid, and Maslinic Acid Interfere with Intracellular Trafficking and N-Linked Glycosylation of Intercellular Adhesion Molecule-1. corosolic acid 14-28 intercellular adhesion molecule 1 Homo sapiens 119-152 30504678-3 2018 In human lung adenocarcinoma A549 cells, asiatic acid, corosolic acid, and maslinic acid interfered with the intracellular transport of ICAM-1 to the cell surface. corosolic acid 55-69 intercellular adhesion molecule 1 Homo sapiens 136-142 30504678-4 2018 Endoglycosidase H-sensitive glycans were linked to ICAM-1 in asiatic acid-, corosolic acid-, and maslinic acid-treated cells. corosolic acid 76-90 intercellular adhesion molecule 1 Homo sapiens 51-57 27836738-0 2017 Blocking inhibition to YAP by ActinomycinD enhances anti-tumor efficacy of Corosolic acid in treating liver cancer. corosolic acid 75-89 Yes1 associated transcriptional regulator Homo sapiens 23-26 30504678-8 2018 These results indicate that asiatic acid, corosolic acid, and maslinic acid interfere with the intracellular transport of ICAM-1 to the cell surface and cause the accumulation of ICAM-1 linked to endoglycosidase H-sensitive glycans. corosolic acid 42-56 intercellular adhesion molecule 1 Homo sapiens 122-128 30504678-8 2018 These results indicate that asiatic acid, corosolic acid, and maslinic acid interfere with the intracellular transport of ICAM-1 to the cell surface and cause the accumulation of ICAM-1 linked to endoglycosidase H-sensitive glycans. corosolic acid 42-56 intercellular adhesion molecule 1 Homo sapiens 179-185 28964635-3 2017 For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively. corosolic acid 67-81 sucrase-isomaltase Homo sapiens 4-21 27393448-0 2016 Corosolic acid suppresses the expression of inflammatory marker genes in CCL4-induced-hepatotoxic rats. corosolic acid 0-14 C-C motif chemokine ligand 4 Rattus norvegicus 73-77 27663281-4 2016 Corosolic acid inhibited ethanol-activated p38 and c-Jun N-terminal kinase MAPK signaling in BRL-3A and HepG2 cells as well as in experimental rats. corosolic acid 0-14 mitogen activated protein kinase 14 Rattus norvegicus 43-46 27663281-5 2016 Corosolic acid restored the ethanol-suppressed expression of autophagy-related genes, including beclin-1 and the ratio of microtubule-associated protein light chain 3II/I (LC3II/I) via AMP-activated protein kinase (AMPK) activation both in vitro and in vivo. corosolic acid 0-14 beclin 1 Rattus norvegicus 96-104 27393448-1 2016 The aim of the study was to asses the anti-inflammatory effects of corosolic acid on the carbon tetrachloride (CCL4) toxicity in rats. corosolic acid 67-81 C-C motif chemokine ligand 4 Rattus norvegicus 111-115 27393448-5 2016 The mRNA levels of proinflammatory cytokines such as TNF-alpha, IL-6, and the inflammatory markers such as iNOS, COX-2 and NF-kB were significantly up regulated in CCl(4) induced rats and treatment with corosolic acid significantly reduced the expression of the above indicators. corosolic acid 203-217 nitric oxide synthase 2 Rattus norvegicus 107-111 27393448-6 2016 Our results suggest that the inhibition of TNF-alpha, IL-6, iNOS, COX-2 and NF-kappaB by corosolic acid, a potential candidate could possess anti-inflammatory activity besides its hepatoprotective effect in CCl4 liver toxicity in rats. corosolic acid 89-103 tumor necrosis factor Rattus norvegicus 43-52 27393448-6 2016 Our results suggest that the inhibition of TNF-alpha, IL-6, iNOS, COX-2 and NF-kappaB by corosolic acid, a potential candidate could possess anti-inflammatory activity besides its hepatoprotective effect in CCl4 liver toxicity in rats. corosolic acid 89-103 interleukin 6 Rattus norvegicus 54-58 27393448-6 2016 Our results suggest that the inhibition of TNF-alpha, IL-6, iNOS, COX-2 and NF-kappaB by corosolic acid, a potential candidate could possess anti-inflammatory activity besides its hepatoprotective effect in CCl4 liver toxicity in rats. corosolic acid 89-103 nitric oxide synthase 2 Rattus norvegicus 60-64 27393448-6 2016 Our results suggest that the inhibition of TNF-alpha, IL-6, iNOS, COX-2 and NF-kappaB by corosolic acid, a potential candidate could possess anti-inflammatory activity besides its hepatoprotective effect in CCl4 liver toxicity in rats. corosolic acid 89-103 cytochrome c oxidase II, mitochondrial Rattus norvegicus 66-71 27393448-6 2016 Our results suggest that the inhibition of TNF-alpha, IL-6, iNOS, COX-2 and NF-kappaB by corosolic acid, a potential candidate could possess anti-inflammatory activity besides its hepatoprotective effect in CCl4 liver toxicity in rats. corosolic acid 89-103 C-C motif chemokine ligand 4 Rattus norvegicus 207-211 26869350-3 2016 RESULTS: In endothelial cells, CRA induced dynamin-related protein 1 (Drp1) phosphorylation at Ser637 and thus inhibited mitochondrial fission in response to oxidative stress. corosolic acid 31-34 dynamin 1-like Mus musculus 43-68 26869350-3 2016 RESULTS: In endothelial cells, CRA induced dynamin-related protein 1 (Drp1) phosphorylation at Ser637 and thus inhibited mitochondrial fission in response to oxidative stress. corosolic acid 31-34 dynamin 1-like Mus musculus 70-74 26926180-9 2016 Furthermore, the effects of CRA on AMPK were confirmed on 3T3-L1 cells by using both AMPK inhibitor and AMPKalpha1/2-specific siRNA RESULTS: CRA attenuated hyperlipidemia, improved insulin sensitivity and glucose intolerance in mice. corosolic acid 28-31 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 35-39 26615974-0 2016 Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. corosolic acid 0-14 interleukin-1 receptor-associated kinase 1 Mus musculus 68-74 26615974-1 2016 Corosolic acid (CA), a triterpenoid compound isolated from Lagerstroemia speciosa L. (Banaba) leaves, exerts anti-inflammatory effects by regulating phosphorylation of interleukin receptor-associated kinase (IRAK)-2 via the NF-kappaB cascade. corosolic acid 0-14 interleukin-1 receptor-associated kinase 2 Mus musculus 168-215 26926180-0 2016 Corosolic acid inhibits adipose tissue inflammation and ameliorates insulin resistance via AMPK activation in high-fat fed mice. corosolic acid 0-14 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 91-95 26926180-14 2016 AMPKalpha knockdown in adipocytes abolished the inhibitory effects of CRA on IKKbeta and IRS-1 serine phosphorylation, indicating that CRA inhibited inflammation and ameliorated insulin resistance via AMPK activation. corosolic acid 70-73 inhibitor of kappaB kinase beta Mus musculus 77-84 26926180-14 2016 AMPKalpha knockdown in adipocytes abolished the inhibitory effects of CRA on IKKbeta and IRS-1 serine phosphorylation, indicating that CRA inhibited inflammation and ameliorated insulin resistance via AMPK activation. corosolic acid 70-73 insulin receptor substrate 1 Mus musculus 89-94 26926180-14 2016 AMPKalpha knockdown in adipocytes abolished the inhibitory effects of CRA on IKKbeta and IRS-1 serine phosphorylation, indicating that CRA inhibited inflammation and ameliorated insulin resistance via AMPK activation. corosolic acid 70-73 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 0-4 28003581-7 2016 Asiatic acid, corosolic acid, glycyrrhetinic acid, oleanolic acid and ursolic acid suppressed octanoylated ghrelin levels in AGS-GHRL8 cells without decreasing transcript expression of GOAT or furin, a protease required for ghrelin maturation. corosolic acid 14-28 appetite-regulating hormone Capra hircus 107-114 25978354-0 2015 Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway. corosolic acid 0-14 kinase insert domain receptor Homo sapiens 81-87 26100106-0 2015 Corosolic acid enhances 5-fluorouracil-induced apoptosis against SNU-620 human gastric carcinoma cells by inhibition of mammalian target of rapamycin. corosolic acid 0-14 mechanistic target of rapamycin kinase Homo sapiens 120-149 25978354-0 2015 Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway. corosolic acid 0-14 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 88-91 25978354-0 2015 Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway. corosolic acid 0-14 protein tyrosine kinase 2 Homo sapiens 92-95 24566423-0 2014 Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of beta-catenin degradation. corosolic acid 40-54 APC regulator of WNT signaling pathway Homo sapiens 85-88 25644809-3 2015 Corosolic acid induced apoptosis in CT-26 cells, mediated by the activation of caspase-3. corosolic acid 0-14 caspase 3 Mus musculus 79-88 25644809-6 2015 In addition, corosolic acid decreased the proliferation and migration of human umbilical vein endothelial cells stimulated by angiopoietin-1. corosolic acid 13-27 angiopoietin 1 Homo sapiens 126-140 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 18-32 protein tyrosine kinase 2 Homo sapiens 66-87 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 18-32 protein tyrosine kinase 2 Homo sapiens 89-92 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 18-32 mitogen-activated protein kinase 3 Homo sapiens 98-104 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 18-32 protein tyrosine kinase 2 Homo sapiens 189-192 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 18-32 angiopoietin 1 Homo sapiens 214-228 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 122-136 protein tyrosine kinase 2 Homo sapiens 66-87 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 122-136 protein tyrosine kinase 2 Homo sapiens 89-92 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 122-136 mitogen-activated protein kinase 3 Homo sapiens 98-104 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 122-136 protein tyrosine kinase 2 Homo sapiens 189-192 25644809-7 2015 Pretreatment with corosolic acid decreased the phosphorylation of focal adhesion kinase (FAK) and ERK1/2, suggesting that corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. corosolic acid 122-136 angiopoietin 1 Homo sapiens 214-228 24566423-0 2014 Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of beta-catenin degradation. corosolic acid 40-54 catenin beta 1 Homo sapiens 137-149 23454206-7 2013 Furthermore, exposure to the ROS scavenger N acetylcysteine (NAC)prevents CRA-induced apoptosis, suggesting a role for ROS in CRA-induced apoptosis. corosolic acid 74-77 synuclein alpha Homo sapiens 61-64 24738052-7 2014 Among 200 purified natural compounds examined, corosolic acid (CA) and oleanolic acid (OA), both are categorized in triterpenoid compounds, inhibited macrophage polarization to M2 phenotype by suppressing STAT3 activation. corosolic acid 47-61 signal transducer and activator of transcription 3 Homo sapiens 205-210 24260055-3 2013 The present study investigated whether corosolic acid (CA), which has been previously reported to be a STAT3 inhibitor, was able to increase the sensitivity to chemotherapeutic drugs in epithelial ovarian cancer cells. corosolic acid 39-53 signal transducer and activator of transcription 3 Homo sapiens 103-108 24481288-0 2014 Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. corosolic acid 0-14 caspase 8 Homo sapiens 89-96 24260055-0 2013 Corosolic acid enhances the antitumor effects of chemotherapy on epithelial ovarian cancer by inhibiting signal transducer and activator of transcription 3 signaling. corosolic acid 0-14 signal transducer and activator of transcription 3 Homo sapiens 105-155 23454206-7 2013 Furthermore, exposure to the ROS scavenger N acetylcysteine (NAC)prevents CRA-induced apoptosis, suggesting a role for ROS in CRA-induced apoptosis. corosolic acid 126-129 synuclein alpha Homo sapiens 61-64 22293444-0 2012 Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-kappaB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. corosolic acid 0-14 chemokine (C-C motif) ligand 2 Mus musculus 151-185 22293444-6 2012 Compared with the control group, the CRA-treated group exhibited a significant decrease in atherosclerotic lesion area, as well as expression of monocyte chemoattractant protein-1 (MCP-1) and CCR2. corosolic acid 37-40 chemokine (C-C motif) ligand 2 Mus musculus 145-179 22293444-6 2012 Compared with the control group, the CRA-treated group exhibited a significant decrease in atherosclerotic lesion area, as well as expression of monocyte chemoattractant protein-1 (MCP-1) and CCR2. corosolic acid 37-40 chemokine (C-C motif) ligand 2 Mus musculus 181-186 22293444-6 2012 Compared with the control group, the CRA-treated group exhibited a significant decrease in atherosclerotic lesion area, as well as expression of monocyte chemoattractant protein-1 (MCP-1) and CCR2. corosolic acid 37-40 chemokine (C-C motif) receptor 2 Mus musculus 192-196 18348886-0 2008 Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation. corosolic acid 0-14 insulin receptor Cricetulus griseus 55-71 20717876-8 2011 The inhibitory potency (IC(50)) of maslinic acid, corosolic acid, and ursolic acid was 7.4, 8.8, and < 10 microM, respectively, using HIM as the enzyme source and 2.8, 4.3, and < 10 microM, respectively, using recombinant CYP3A4 as the enzyme source. corosolic acid 50-64 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 228-234 20564492-4 2010 Corosolic acid also triggered the activation of caspase-3 and poly (ADP-ribose) polymerase, while it was recovered by Z-VAD-FMK. corosolic acid 0-14 caspase 3 Homo sapiens 48-90 20564492-5 2010 Moreover, the cell growth/apoptosis activities of corosolic acid were regulated by the AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signals. corosolic acid 50-64 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 147-151 20564492-5 2010 Moreover, the cell growth/apoptosis activities of corosolic acid were regulated by the AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signals. corosolic acid 50-64 mechanistic target of rapamycin kinase Homo sapiens 152-156 20564492-6 2010 These results showed that corosolic acid-mediated AMPK activation leads to inhibition of mTOR, thus providing a possible mechanism of action of corosolic acid in the inhibition of cancer cell growth and the induction of apoptosis. corosolic acid 26-40 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 50-54 20564492-6 2010 These results showed that corosolic acid-mediated AMPK activation leads to inhibition of mTOR, thus providing a possible mechanism of action of corosolic acid in the inhibition of cancer cell growth and the induction of apoptosis. corosolic acid 26-40 mechanistic target of rapamycin kinase Homo sapiens 89-93 20564492-6 2010 These results showed that corosolic acid-mediated AMPK activation leads to inhibition of mTOR, thus providing a possible mechanism of action of corosolic acid in the inhibition of cancer cell growth and the induction of apoptosis. corosolic acid 144-158 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 50-54 20564492-6 2010 These results showed that corosolic acid-mediated AMPK activation leads to inhibition of mTOR, thus providing a possible mechanism of action of corosolic acid in the inhibition of cancer cell growth and the induction of apoptosis. corosolic acid 144-158 mechanistic target of rapamycin kinase Homo sapiens 89-93 19441063-5 2009 Corosolic acid induced NF-kappaB and MAP kinase activity at an early stage of osteoblast differentiation and increased the activity of the transcription factor AP-1 during late-stage osteoblast differentiation. corosolic acid 0-14 jun proto-oncogene Mus musculus 160-164 21341336-0 2011 Corosolic acid triggers mitochondria and caspase-dependent apoptotic cell death in osteosarcoma MG-63 cells. corosolic acid 0-14 caspase 8 Homo sapiens 41-48 21341336-3 2011 It was found that corosolic acid increased the Bax/Bcl-2 ratio by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. corosolic acid 18-32 BCL2 associated X, apoptosis regulator Homo sapiens 47-50 21341336-3 2011 It was found that corosolic acid increased the Bax/Bcl-2 ratio by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. corosolic acid 18-32 BCL2 apoptosis regulator Homo sapiens 51-56 21341336-3 2011 It was found that corosolic acid increased the Bax/Bcl-2 ratio by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. corosolic acid 18-32 BCL2 associated X, apoptosis regulator Homo sapiens 80-83 21341336-3 2011 It was found that corosolic acid increased the Bax/Bcl-2 ratio by up-regulating Bax expression, disrupted mitochondrial membrane potential and triggered the release of cytochrome c from mitochondria into the cytoplasm. corosolic acid 18-32 cytochrome c, somatic Homo sapiens 168-180 21341336-4 2011 Corosolic acid treatment triggered the activation of caspase-8, 9 and 3. corosolic acid 0-14 caspase 8 Homo sapiens 53-71 21341336-6 2011 Moreover, pretreatment of CsA, a cyclophilin D ligand that inhibits mitochondria potential uncoupling, prevented the activation of caspase-9 and caspase-3, but not caspase-8, and the apoptosis of MG-63 cells, triggered by corosolic acid. corosolic acid 222-236 peptidylprolyl isomerase D Homo sapiens 33-46 21341336-6 2011 Moreover, pretreatment of CsA, a cyclophilin D ligand that inhibits mitochondria potential uncoupling, prevented the activation of caspase-9 and caspase-3, but not caspase-8, and the apoptosis of MG-63 cells, triggered by corosolic acid. corosolic acid 222-236 caspase 9 Homo sapiens 131-140 21341336-7 2011 All these results indicated that corosolic acid-induced apoptosis was associated with the activation of caspases via a mitochondrial pathway. corosolic acid 33-47 caspase 8 Homo sapiens 104-112 21073634-0 2011 Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. corosolic acid 0-14 signal transducer and activator of transcription 3 Homo sapiens 89-139 21073634-0 2011 Corosolic acid inhibits glioblastoma cell proliferation by suppressing the activation of signal transducer and activator of transcription-3 and nuclear factor-kappa B in tumor cells and tumor-associated macrophages. corosolic acid 0-14 nuclear factor kappa B subunit 1 Homo sapiens 144-166 21073634-3 2011 Among 130 purified natural compounds examined, corosolic acid significantly inhibited the expression of CD163, one of the phenotype markers of M2 macrophages, and also suppressed the secretion of IL-10, one of the anti-inflammatory cytokines preferentially produced by M2 macrophages, thus suggesting that corosolic acid suppresses M2 polarization of macrophages. corosolic acid 47-61 CD163 molecule Homo sapiens 104-109 21073634-3 2011 Among 130 purified natural compounds examined, corosolic acid significantly inhibited the expression of CD163, one of the phenotype markers of M2 macrophages, and also suppressed the secretion of IL-10, one of the anti-inflammatory cytokines preferentially produced by M2 macrophages, thus suggesting that corosolic acid suppresses M2 polarization of macrophages. corosolic acid 47-61 interleukin 10 Homo sapiens 196-201 21073634-4 2011 Furthermore, corosolic acid inhibited the proliferation of glioblastoma cells, U373 and T98G, and the activation of signal transducer and activator of transcription-3 (STAT3) and nuclear factor-kappa B (NF-kappaB) in both human macrophages and glioblastoma cells. corosolic acid 13-27 signal transducer and activator of transcription 3 Homo sapiens 116-166 21073634-4 2011 Furthermore, corosolic acid inhibited the proliferation of glioblastoma cells, U373 and T98G, and the activation of signal transducer and activator of transcription-3 (STAT3) and nuclear factor-kappa B (NF-kappaB) in both human macrophages and glioblastoma cells. corosolic acid 13-27 signal transducer and activator of transcription 3 Homo sapiens 168-173 21073634-4 2011 Furthermore, corosolic acid inhibited the proliferation of glioblastoma cells, U373 and T98G, and the activation of signal transducer and activator of transcription-3 (STAT3) and nuclear factor-kappa B (NF-kappaB) in both human macrophages and glioblastoma cells. corosolic acid 13-27 nuclear factor kappa B subunit 1 Homo sapiens 179-201 21073634-4 2011 Furthermore, corosolic acid inhibited the proliferation of glioblastoma cells, U373 and T98G, and the activation of signal transducer and activator of transcription-3 (STAT3) and nuclear factor-kappa B (NF-kappaB) in both human macrophages and glioblastoma cells. corosolic acid 13-27 nuclear factor kappa B subunit 1 Homo sapiens 203-212 21073634-5 2011 These results indicate that corosolic acid suppresses the M2 polarization of macrophages and tumor cell proliferation by inhibiting both STAT3 and NF-kappaB activation. corosolic acid 28-42 signal transducer and activator of transcription 3 Homo sapiens 137-142 21073634-5 2011 These results indicate that corosolic acid suppresses the M2 polarization of macrophages and tumor cell proliferation by inhibiting both STAT3 and NF-kappaB activation. corosolic acid 28-42 nuclear factor kappa B subunit 1 Homo sapiens 147-156 19457606-0 2009 Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells. corosolic acid 0-14 caspase 8 Homo sapiens 67-74 19457606-5 2009 Moreover, CRA treatment triggered the activation of caspase-8, -9 and -3 in HeLa cells. corosolic acid 10-13 caspase 8 Homo sapiens 52-72 18348886-6 2008 Furthermore, Corosolic acid inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. corosolic acid 13-27 proto-oncogene tyrosine-protein kinase Src Cricetulus griseus 177-180 18348886-6 2008 Furthermore, Corosolic acid inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. corosolic acid 13-27 proto-oncogene tyrosine-protein kinase Src Cricetulus griseus 208-211 18379057-7 2008 In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR) alpha in liver and PPAR gamma in WAT. corosolic acid 13-16 peroxisome proliferator activated receptor alpha Mus musculus 55-97 18379057-7 2008 In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR) alpha in liver and PPAR gamma in WAT. corosolic acid 13-16 peroxisome proliferator activated receptor alpha Mus musculus 99-103 18379057-7 2008 In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR) alpha in liver and PPAR gamma in WAT. corosolic acid 13-16 peroxisome proliferator activated receptor gamma Mus musculus 124-134 18379057-8 2008 This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPAR alpha in liver and PPAR gamma in WAT. corosolic acid 37-40 peroxisome proliferator activated receptor alpha Mus musculus 195-205 18379057-8 2008 This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPAR alpha in liver and PPAR gamma in WAT. corosolic acid 37-40 peroxisome proliferator activated receptor gamma Mus musculus 219-229 34588426-0 2021 Corosolic acid inhibits cancer progression by decreasing the level of CDK19-mediated O-GlcNAcylation in liver cancer cells. corosolic acid 0-14 cyclin dependent kinase 19 Homo sapiens 70-75 17392131-5 2007 Corosolic acid suppressed the differentiation of 3T3-L1 pre-adipocytes and down-regulated the expression of PPAR-gamma and C/EBP-alpha mRNA (p<0.01, vs control group). corosolic acid 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 108-118 17392131-5 2007 Corosolic acid suppressed the differentiation of 3T3-L1 pre-adipocytes and down-regulated the expression of PPAR-gamma and C/EBP-alpha mRNA (p<0.01, vs control group). corosolic acid 0-14 CCAAT enhancer binding protein alpha Homo sapiens 123-134 17392131-6 2007 Corosolic acid promotes the 3H-glucose uptaking, suppresses the differentiation and downregulates the expression of PPAR-gamma and C/EBP-alpha mRNA in 3T3-L1 adipocytes. corosolic acid 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 116-126 17392131-6 2007 Corosolic acid promotes the 3H-glucose uptaking, suppresses the differentiation and downregulates the expression of PPAR-gamma and C/EBP-alpha mRNA in 3T3-L1 adipocytes. corosolic acid 0-14 CCAAT enhancer binding protein alpha Homo sapiens 131-142 34678723-6 2021 Furthermore, we found that corosolic acid destabilized the glutathione peroxidase 2-mediated redox system, which increased mitochondrial and liposomal oxidative stress. corosolic acid 27-41 glutathione peroxidase 2 Homo sapiens 59-83 34678723-7 2021 Corosolic acid also decreased the targeting protein for TPX2 level, which inhibited PI3K/AKT signaling and induced apoptosis. corosolic acid 0-14 TPX2 microtubule nucleation factor Homo sapiens 56-60 34678723-7 2021 Corosolic acid also decreased the targeting protein for TPX2 level, which inhibited PI3K/AKT signaling and induced apoptosis. corosolic acid 0-14 AKT serine/threonine kinase 1 Homo sapiens 89-92 15256748-0 2004 Corosolic acid induces GLUT4 translocation in genetically type 2 diabetic mice. corosolic acid 0-14 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 23-28 34445346-0 2021 Modulating the ERK1/2-MMP1 Axis through Corosolic Acid Inhibits Metastasis of Human Oral Squamous Cell Carcinoma Cells. corosolic acid 40-54 mitogen-activated protein kinase 3 Homo sapiens 15-21 34213784-0 2021 Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-beta1/Smad2, NF-kappaB, and AMPK signaling pathways. corosolic acid 0-14 transforming growth factor beta 1 Homo sapiens 121-130 34213784-0 2021 Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-beta1/Smad2, NF-kappaB, and AMPK signaling pathways. corosolic acid 0-14 SMAD family member 2 Homo sapiens 131-136 34213784-0 2021 Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-beta1/Smad2, NF-kappaB, and AMPK signaling pathways. corosolic acid 0-14 nuclear factor kappa B subunit 1 Homo sapiens 138-147 34213784-0 2021 Corosolic acid ameliorates non-alcoholic steatohepatitis induced by high-fat diet and carbon tetrachloride by regulating TGF-beta1/Smad2, NF-kappaB, and AMPK signaling pathways. corosolic acid 0-14 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 153-157 34445346-0 2021 Modulating the ERK1/2-MMP1 Axis through Corosolic Acid Inhibits Metastasis of Human Oral Squamous Cell Carcinoma Cells. corosolic acid 40-54 matrix metallopeptidase 1 Homo sapiens 22-26 35630550-2 2022 We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha. corosolic acid 42-56 intercellular adhesion molecule 1 Homo sapiens 142-175 35630550-2 2022 We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha. corosolic acid 42-56 intercellular adhesion molecule 1 Homo sapiens 177-183 35630550-2 2022 We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha. corosolic acid 42-56 TNF receptor superfamily member 8 Homo sapiens 262-270 35630550-2 2022 We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha. corosolic acid 42-56 interleukin 1 alpha Homo sapiens 271-289