PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11752634-2	2001	The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids.	inositol lipids	106-121	extracellular matrix protein 1	Mus musculus	4-7
11752634-2	2001	The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids.	inositol lipids	106-121	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	40-44
11752634-2	2001	The p85 regulatory subunit recruits the p110 catalytic subunit to the membrane, where p110 phosphorylates inositol lipids.	inositol lipids	106-121	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Mus musculus	86-90
10998360-4	2000	Tiam1 bound to polyphosphorylated inositol lipids in the rank order PtdIns(3,4,5)P(3)>PtdIns(3,4)P(2) >>PtdIns(4,5)P(2), and this binding could be attributed to the N-terminal pleckstrin-homology (N-PH) domain.	inositol lipids	34-49	T cell lymphoma invasion and metastasis 1	Mus musculus	0-5
11729971-2	2001	Among the enzymes of the cycle we and others have demonstrated that phospholipase C specific for inositol lipids (PLC) is one of the main steps of the inositol lipid cycle.	inositol lipids	97-112	heparan sulfate proteoglycan 2	Homo sapiens	114-117
10209156-1	1999	Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3" position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3.	inositol lipids	49-64	peptidase inhibitor 3	Homo sapiens	149-159
10497072-3	1999	Among the enzymes activated by 3"-phosphorylated inositol lipids is Akt/protein kinase B (PKB).	inositol lipids	49-64	AKT serine/threonine kinase 1	Homo sapiens	68-88
10497072-3	1999	Among the enzymes activated by 3"-phosphorylated inositol lipids is Akt/protein kinase B (PKB).	inositol lipids	49-64	AKT serine/threonine kinase 1	Homo sapiens	90-93
10625953-2	1999	It has been demonstrated that phospholipase C specific for inositol lipids (PLC) is one of the main steps of the inositol lipid cycle.	inositol lipids	59-74	heparan sulfate proteoglycan 2	Homo sapiens	76-79
10491207-1	1999	The pleckstrin homology (PH) domains of phospholipase C (PLC)-delta1 and a related catalytically inactive protein, p130, both bind inositol phosphates and inositol lipids.	inositol lipids	155-170	phospholipase C delta 1	Homo sapiens	40-68
10491207-1	1999	The pleckstrin homology (PH) domains of phospholipase C (PLC)-delta1 and a related catalytically inactive protein, p130, both bind inositol phosphates and inositol lipids.	inositol lipids	155-170	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	115-119
8380735-17	1993	The phosphorylated receptor associates ras GAP, phospholipase C-gamma, and src-related tyrosine kinase in vitro; Phosphatidylinositol 3-kinase, in vitro and in vivo, indicating that the generation of the D-3 phosphorylated inositol lipids is involved in effecting the motility and/or the growth response to HGF.	inositol lipids	223-238	hepatocyte growth factor	Homo sapiens	307-310
9359428-2	1997	Here we demonstrate that an increase in Ca2+ ion concentration within the physiological range (0.1-10 microM) is sufficient to stimulate PLCdelta1, but not PLCgamma1 and PLCbeta1, to hydrolyse cellular inositol lipids present in permeabilized cells.	inositol lipids	202-217	phospholipase C delta 1	Homo sapiens	137-146
9042301-3	1996	Previous observations dealing with signal transduction have established phospholipase C, specific for inositol lipids (PLC), an important step in the inositol lipid cycle.	inositol lipids	102-117	heparan sulfate proteoglycan 2	Homo sapiens	119-122
8869743-3	1996	Previous observation have established that the nucleus possesses a specific PLC for inositol lipids, i.e., the PLC beta 1 isoform, which undergoes rapid and transient activation after IGF-I stimulation of quiescent Swiss 3T3 cells and is down-regulated after treatment of Friend erythroleukemia cells with DMSO.	inositol lipids	84-99	phospholipase C, beta 1	Mus musculus	111-121
8869743-3	1996	Previous observation have established that the nucleus possesses a specific PLC for inositol lipids, i.e., the PLC beta 1 isoform, which undergoes rapid and transient activation after IGF-I stimulation of quiescent Swiss 3T3 cells and is down-regulated after treatment of Friend erythroleukemia cells with DMSO.	inositol lipids	84-99	insulin-like growth factor 1	Mus musculus	184-189
8384450-3	1993	Insulin-like growth factor-I stimulated the accumulation of 3-phosphorylated inositol lipids in intact cells and the appearance of P13K in antiphosphotyrosine-antibody-directed immunoprecipitates prepared from lysed cells, suggesting that P13K had been activated by a mechanism involving a protein tyrosine kinase.	inositol lipids	77-92	insulin like growth factor 1	Homo sapiens	0-28
9434133-1	1997	The pleckstrin homology domains (PH domains) derived from four different proteins, the N-terminal part of pleckstrin, RAC-protein kinase, diacylglycerol kinase and the 130 kDa protein originally cloned as an inositol 1,4,5-trisphosphate binding protein, were analysed for binding of inositol phosphates and derivatives of inositol lipids.	inositol lipids	322-337	pleckstrin	Homo sapiens	4-14
8663246-1	1996	Membrane-associated phospholipase D (PLD) in HL60 cells can be activated by the small GTP-binding proteins Arf and RhoA, but polyphosphorylated inositol lipids were required for maximum activity.	inositol lipids	144-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	20-35
8663246-1	1996	Membrane-associated phospholipase D (PLD) in HL60 cells can be activated by the small GTP-binding proteins Arf and RhoA, but polyphosphorylated inositol lipids were required for maximum activity.	inositol lipids	144-159	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-40
8380575-0	1993	Hydrolysis of short acyl chain inositol lipids by phospholipase C-delta 1.	inositol lipids	31-46	phospholipase C delta 1	Bos taurus	50-73
1356018-10	1992	Thus, the metabolism of inositol lipids is probably a major biochemical pathway utilized by the neu/erbB-2 tyrosine kinase.	inositol lipids	24-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-99
1321347-3	1992	These IGF-1-dependent changes in inositol lipids coincide with an increase in nuclear diacyglycerol and precede translocation to the nucleus and activation of protein kinase C (refs 5, 6).	inositol lipids	33-48	insulin-like growth factor 1	Mus musculus	6-11
1356018-10	1992	Thus, the metabolism of inositol lipids is probably a major biochemical pathway utilized by the neu/erbB-2 tyrosine kinase.	inositol lipids	24-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-106
2155909-14	1990	Our results show that in Swiss 3T3 cells the bombesin receptor activates the hydrolysis of inositol lipids as a mechanism of signal transduction, which consequently causes changes in Ca2+i and pHi.	inositol lipids	91-106	glucose-6-phosphate isomerase 1	Mus musculus	193-196
2173558-0	1990	Thyrotropin-releasing hormone receptor occupancy determines the fraction of the responsive pool of inositol lipids hydrolysed in rat pituitary tumour cells.	inositol lipids	99-114	thyrotropin releasing hormone receptor	Rattus norvegicus	0-38
1936266-5	1991	Epidermal growth factor (EGF), and platelet-derived growth factor (PDGF) stimulated the "classical" turnover of inositol lipids with formation of diacylglycerol and calcium-mobilizing inositol phosphates.	inositol lipids	112-127	epidermal growth factor	Mus musculus	0-23
1936266-5	1991	Epidermal growth factor (EGF), and platelet-derived growth factor (PDGF) stimulated the "classical" turnover of inositol lipids with formation of diacylglycerol and calcium-mobilizing inositol phosphates.	inositol lipids	112-127	epidermal growth factor	Mus musculus	25-28
2170406-6	1990	PAF-stimulated deacylation and phosphodiesteric hydrolysis of inositol lipids were differentially affected by cholera toxin and pertussis toxin.	inositol lipids	62-77	PCNA clamp associated factor	Rattus norvegicus	0-3
2537320-3	1989	In addition, increased concentrations of IP3 and IP2 were observed in CEFs infected with the RSV temperature-sensitive transformation mutant NY72-4 when maintained at the permissive temperature (35 degrees C) for greater than 24 h. Slight increases were observed in the amounts of inositol lipids in RSV-transformed cells.	inositol lipids	281-296	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	49-52
2538419-9	1989	Thrombin also stimulates PI metabolism and calcium mobilization in these cells and brought about both a prolonged decrease in inositol lipids and inhibition of PI kinase activity.	inositol lipids	126-141	coagulation factor II	Rattus norvegicus	0-8
2843607-5	1988	After incubation for 20 h with NGF, an increased binding of [3H]BK to the PC12 (+) cells was observed at 4 degrees C. Exposure of the cells for 30 min to 25 mM LiCl enhanced the effect of BK on the inositol incorporation into total inositol lipids, especially in PC12(+) cells.	inositol lipids	232-247	nerve growth factor	Rattus norvegicus	31-34
2613862-0	1989	Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells.	inositol lipids	45-60	epidermal growth factor	Mus musculus	0-23
2446607-3	1987	PHA and AlF4- stimulated the breakdown of inositol lipids via both the phospholipase A and C pathways when added to intact lymphocytes.	inositol lipids	42-57	phospholipase A and acyltransferase 1	Homo sapiens	71-86
3046609-0	1988	Early effects of Escherichia coli endotoxin infusion on vasopressin-stimulated breakdown and metabolism of inositol lipids in rat hepatocytes.	inositol lipids	107-122	arginine vasopressin	Rattus norvegicus	56-67
6525180-0	1984	Inositol lipids, phosphatidate and diacylglycerol share stearoylarachidonoylglycerol as a common backbone in thrombin-stimulated human platelets.	inositol lipids	0-15	coagulation factor II, thrombin	Homo sapiens	109-117
2866765-0	1985	Transformation of BALB/3T3 cells with EJ/T24/H-ras oncogene inhibits adenylate cyclase response to beta-adrenergic agonist while increases muscarinic receptor dependent hydrolysis of inositol lipids.	inositol lipids	183-198	Harvey rat sarcoma virus oncogene	Mus musculus	45-50
2412047-1	1985	The release reaction and the metabolism of inositol lipids were studied in parallel in washed human platelets following the activation by low doses of thrombin.	inositol lipids	43-58	coagulation factor II, thrombin	Homo sapiens	151-159
3014544-3	1986	In accordance with the V1 character of the receptors, vasopressin activated the turnover of membrane inositol lipids, and this effect was abolished by a structural analogue known to act as a vasopressor antagonist.	inositol lipids	101-116	arginine vasopressin	Rattus norvegicus	54-65
3014544-6	1986	This reduction in ganglionic transmission was antagonized by the same synthetic structural analogue that blocked the effect of vasopressin on inositol lipids.	inositol lipids	142-157	arginine vasopressin	Rattus norvegicus	127-138
2869037-10	1986	The rapidity of the inositol phosphate response as well as the close correspondence between the bradykinin type-2 receptor mediated hydrolysis of polyphosphoinositides and changes in prostacyclin synthesis, vessel dilation, and permeability suggests that breakdown products of inositol lipids serve as second messengers mediating the effects of bradykinin on the vascular endothelium.	inositol lipids	277-292	kininogen 1	Bos taurus	96-106
19814798-6	2009	Eps15 has been shown to bind to AP-1 and AP-2 complexes, to bind to inositol lipids and to several other proteins involved in the regulation of intracellular trafficking.	inositol lipids	68-83	epidermal growth factor receptor pathway substrate 15	Homo sapiens	0-5
32418222-11	2020	Here we describe a patient with a complex neurological phenotype, premature aging and a mutation in PI4K2A, illustrating the importance of this enzyme in the generation of inositol lipids with particular acylation characteristics.	inositol lipids	172-187	phosphatidylinositol 4-kinase type 2 alpha	Homo sapiens	100-106
6091624-2	1984	In certain conditions thrombin and collagen cause secretion while [Ca2+]i remains at basal concentrations, a response attributed to activation of protein kinase by diacylglycerol formed by hydrolysis of inositol lipids.	inositol lipids	203-218	coagulation factor II, thrombin	Homo sapiens	22-30
23836884-1	2013	Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs).	inositol lipids	46-61	huntingtin interacting protein 1	Homo sapiens	0-32
23836884-1	2013	Huntingtin-interacting protein 1 (HIP1) binds inositol lipids, clathrin, actin, and receptor tyrosine kinases (RTKs).	inositol lipids	46-61	huntingtin interacting protein 1	Homo sapiens	34-38
17652185-0	2007	An autocrine insulin feedback loop maintains pancreatic beta-cell 3-phosphorylated inositol lipids.	inositol lipids	83-98	insulin	Mesocricetus auratus	13-20
15985468-4	2005	The data from GAP1(m) and the PI-PLCdelta(1) PH domain show that, when proteins associate with inositol lipids in the plasma membrane, they retain a mobility similar to that in the cytoplasm, and probably also similar to the inositol lipid to which they are attached, suggesting a free diffusion within the plane of the membrane.	inositol lipids	95-110	RAS p21 protein activator 2	Homo sapiens	14-21
17452370-1	2007	The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin and actin.	inositol lipids	143-158	huntingtin interacting protein 1	Mus musculus	19-51
17452370-1	2007	The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin and actin.	inositol lipids	143-158	huntingtin interacting protein 1	Mus musculus	53-57
17452370-1	2007	The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin and actin.	inositol lipids	143-158	huntingtin interacting protein 1	Mus musculus	67-71
17452370-1	2007	The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin and actin.	inositol lipids	143-158	huntingtin interacting protein 1	Mus musculus	67-71
17452370-1	2007	The members of the huntingtin-interacting protein-1 (HIP1) family, HIP1 and HIP1-related (HIP1r), are multi-domain proteins that interact with inositol lipids, clathrin and actin.	inositol lipids	143-158	huntingtin interacting protein 1 related	Mus musculus	90-95
17465329-2	2007	Phosphoinositide 3-kinase (PI3K) generates specific 3"-phosphorylated inositol lipids that have been implicated in a multitude of cell functions.	inositol lipids	70-85	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	0-25
12960423-8	2003	Functional analysis of the effects of ATRAP on angiotensin II-induced AT1 receptor signaling reveals a moderate decrease in the generation of inositol lipids, a marked decrease in the angiotensin II-stimulated transcriptional activity of the c-fos promoter luciferase reporter gene, and a decrease in cell proliferation.	inositol lipids	142-157	angiotensin II receptor associated protein	Homo sapiens	38-43
15634688-4	2005	The non-dividing ino1 mutant was highly resistant to inositol starvation, reflecting the slow turnover of inositol lipids in this stage.	inositol lipids	106-121	inositol-3-phosphate synthase 1	Homo sapiens	17-21
14732715-2	2004	Here we demonstrate that both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains.	inositol lipids	50-65	huntingtin interacting protein 1 related	Homo sapiens	30-35
14732715-2	2004	Here we demonstrate that both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains.	inositol lipids	50-65	huntingtin interacting protein 1	Homo sapiens	30-34
14732715-6	2004	Although HIP1r and HIP1 display only a partially overlapping pattern of protein interactions, these data suggest that both proteins share a functional homology by binding 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases in a fashion that may contribute to their ability to alter cell growth and survival.	inositol lipids	188-203	huntingtin interacting protein 1 related	Homo sapiens	9-14
14732715-6	2004	Although HIP1r and HIP1 display only a partially overlapping pattern of protein interactions, these data suggest that both proteins share a functional homology by binding 3-phosphorylated inositol lipids and stabilizing receptor tyrosine kinases in a fashion that may contribute to their ability to alter cell growth and survival.	inositol lipids	188-203	huntingtin interacting protein 1	Homo sapiens	9-13
12960423-8	2003	Functional analysis of the effects of ATRAP on angiotensin II-induced AT1 receptor signaling reveals a moderate decrease in the generation of inositol lipids, a marked decrease in the angiotensin II-stimulated transcriptional activity of the c-fos promoter luciferase reporter gene, and a decrease in cell proliferation.	inositol lipids	142-157	angiotensinogen	Homo sapiens	47-61
12960423-8	2003	Functional analysis of the effects of ATRAP on angiotensin II-induced AT1 receptor signaling reveals a moderate decrease in the generation of inositol lipids, a marked decrease in the angiotensin II-stimulated transcriptional activity of the c-fos promoter luciferase reporter gene, and a decrease in cell proliferation.	inositol lipids	142-157	angiotensin II receptor type 1	Homo sapiens	70-73