PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35460420-10 2022 miR-431-5p serves as a prognostic biomarker in CRC, and hUCMSC-Exos transfer of miR-431-5p decelerates CRC cell growth by inhibiting PRDX1. -5p 87-90 peroxiredoxin 1 Homo sapiens 133-138 34407684-9 2021 Regarding the mechanism, miR-424-5p was identified as the downstream target of CASC9, and the interaction between CASC9 and miR-424-5p promoted thioredoxin-interacting protein (TXNIP) expression. -5p 131-134 microRNA 424 Homo sapiens 25-32 34407684-9 2021 Regarding the mechanism, miR-424-5p was identified as the downstream target of CASC9, and the interaction between CASC9 and miR-424-5p promoted thioredoxin-interacting protein (TXNIP) expression. -5p 131-134 cancer susceptibility 9 Homo sapiens 79-84 34407684-9 2021 Regarding the mechanism, miR-424-5p was identified as the downstream target of CASC9, and the interaction between CASC9 and miR-424-5p promoted thioredoxin-interacting protein (TXNIP) expression. -5p 131-134 cancer susceptibility 9 Homo sapiens 114-119 34407684-9 2021 Regarding the mechanism, miR-424-5p was identified as the downstream target of CASC9, and the interaction between CASC9 and miR-424-5p promoted thioredoxin-interacting protein (TXNIP) expression. -5p 131-134 thioredoxin interacting protein Homo sapiens 144-175 34407684-9 2021 Regarding the mechanism, miR-424-5p was identified as the downstream target of CASC9, and the interaction between CASC9 and miR-424-5p promoted thioredoxin-interacting protein (TXNIP) expression. -5p 131-134 thioredoxin interacting protein Homo sapiens 177-182 34529319-6 2021 In mechanism, SNHG14 served as a sponge of microRNA-17-5p (miR-17-5p), and misshapen like kinase 1 (MINK1) was a target of miR-17-5p. -5p 54-57 small nucleolar RNA host gene 14 Homo sapiens 14-20 34529319-6 2021 In mechanism, SNHG14 served as a sponge of microRNA-17-5p (miR-17-5p), and misshapen like kinase 1 (MINK1) was a target of miR-17-5p. -5p 54-57 microRNA 17 Homo sapiens 59-68 34803150-8 2022 NEAT1 functioned as a molecular sponge of miR-423-5p, and NEAT1 silencing-mediated effects were partly overturned by miR-423-5p interference in HG-induced SV40 MES13 cells. -5p 49-52 nuclear paraspeckle assembly transcript 1 (non-protein coding) Mus musculus 0-5 34803150-8 2022 NEAT1 functioned as a molecular sponge of miR-423-5p, and NEAT1 silencing-mediated effects were partly overturned by miR-423-5p interference in HG-induced SV40 MES13 cells. -5p 49-52 microRNA 423 Mus musculus 117-124 34512753-9 2021 At the same time, further experiments demonstrated that miR-485-5p inhibition reversed the suppression of SNHG7 knockdown on gastric cancer cells proliferation, migration, and invasion. -5p 63-66 small nucleolar RNA host gene 7 Homo sapiens 106-111 30015912-0 2018 miR-185-5p inhibits F-actin polymerization and reverses epithelial mesenchymal transition of human breast cancer cells by modulating RAGE. -5p 7-10 advanced glycosylation end-product specific receptor Homo sapiens 133-137 33300070-9 2021 Collectively, the results of the present study suggested that let7f-5p inhibited inflammation by targeting MAPK6 in the in vitro pneumonia model, thus let7f-5p may serve as a potential novel therapeutic target for pneumonia. -5p 67-70 mitogen-activated protein kinase 6 Homo sapiens 107-112 32028704-7 2020 We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity. -5p 19-22 sterol regulatory element binding transcription factor 2 Homo sapiens 23-29 32028704-7 2020 We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity. -5p 19-22 sterol regulatory element binding transcription factor 2 Homo sapiens 62-68 32028704-7 2020 We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity. -5p 19-22 microRNA 28 Homo sapiens 130-136 32028704-7 2020 We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity. -5p 19-22 sterol regulatory element binding transcription factor 2 Homo sapiens 62-68 32028704-7 2020 We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity. -5p 19-22 microRNA 28 Homo sapiens 130-136 30595117-7 2019 Mean arterial pressure on a 4% NaCl high-salt diet at day 14 post anti-miR-192-5p treatment was 16 mm Hg higher than in rats treated with scrambled anti-miR (n=8 and 6; P<0.05). -5p 78-81 myosin regulatory light chain interacting protein Rattus norvegicus 71-74 35409056-9 2022 Collectively, our findings demonstrate that 7-KC-induced miR-107-5p promotes differentiation and function of OCs by downregulating MKP1. -5p 64-67 dual specificity phosphatase 1 Mus musculus 131-135 33913671-11 2022 Western blotting results showed that ILF3-AS1 overexpression promoted PDK1 expression, which was prevented by miR-493-5p overexpression in SK-MEL-1 cells. -5p 117-120 interleukin enhancer binding factor 3 Homo sapiens 37-41 33913671-11 2022 Western blotting results showed that ILF3-AS1 overexpression promoted PDK1 expression, which was prevented by miR-493-5p overexpression in SK-MEL-1 cells. -5p 117-120 prostaglandin D2 receptor Homo sapiens 42-45 33913671-11 2022 Western blotting results showed that ILF3-AS1 overexpression promoted PDK1 expression, which was prevented by miR-493-5p overexpression in SK-MEL-1 cells. -5p 117-120 pyruvate dehydrogenase kinase 1 Homo sapiens 70-74 33827415-6 2021 The levels of occludin mRNA and protein in the miR-122-5p mimic group were significantly lower than that in the other groups (p < 0.05), which indicates that miR-122-5p reduces the expression of occludin. -5p 54-57 occludin Mus musculus 14-22 33827415-6 2021 The levels of occludin mRNA and protein in the miR-122-5p mimic group were significantly lower than that in the other groups (p < 0.05), which indicates that miR-122-5p reduces the expression of occludin. -5p 54-57 occludin Mus musculus 195-203 33264082-7 2020 Subsequently, we found that GAS5 served as a sponge for miR-452-5p in CCI rats and CELF2 was the downstream target of miR-452-5p. -5p 63-66 growth arrest specific 5 Rattus norvegicus 28-32 33123264-5 2020 In summary, SPOCK1 was found to be a target gene of miR155-5p in prostate cancer, and miR-155-5p acts as a tumor-suppressor gene and may inhibit SPOCK1-mediated prostate cancer progression. -5p 58-61 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Homo sapiens 12-18 31387890-6 2019 Mechanistically, in cytoplasm, CCAT1 sponges miR-28-5p to prevent the anti-cancer effect. -5p 51-54 colon cancer associated transcript 1 Homo sapiens 31-36 30066886-8 2018 Upregulated miR-182-5p abrogated the effect of GAS5 overexpression on CRC cell proliferation and apoptosis. -5p 19-22 growth arrest specific 5 Homo sapiens 47-51 28052756-8 2017 Dysregulation of miR-17-5p, miR-26a-5p, miR-486-5p, miR-122-5p, miR-184 and miR-20a-5p was found to target three pathways (PTEN, PI3K/AKT and STAT). -5p 23-26 phosphatase and tensin homolog Bos taurus 123-127 29436647-2 2018 It was hypothesized that microRNA 21-5p(miR-21-5p) can promote the survival of type II alveolar epithelial cells (AECII), alleviating HALI. -5p 36-39 microRNA 215 Homo sapiens 40-49 28961370-5 2017 AIMS: To demonstrate whether miR-181d-5p can promote neurite outgrowth in PC12 cells via PI3K/Akt signaling pathway, we performed function analysis of miR-181d-5p with LV-miR-181d-5p and LV-sh-GFP to infect PC12 cells. -5p 37-40 microRNA 181d Rattus norvegicus 151-159 28961370-5 2017 AIMS: To demonstrate whether miR-181d-5p can promote neurite outgrowth in PC12 cells via PI3K/Akt signaling pathway, we performed function analysis of miR-181d-5p with LV-miR-181d-5p and LV-sh-GFP to infect PC12 cells. -5p 37-40 microRNA 181d Rattus norvegicus 151-159 28052756-8 2017 Dysregulation of miR-17-5p, miR-26a-5p, miR-486-5p, miR-122-5p, miR-184 and miR-20a-5p was found to target three pathways (PTEN, PI3K/AKT and STAT). -5p 23-26 AKT serine/threonine kinase 1 Bos taurus 134-137