PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33338868-0	2021	Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer"s disease.	genipin	28-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-80
33735403-6	2021	HT22 cells were treated with/without different concentrations of the UCP2-specific inhibitor genipin for different periods of time.	genipin	93-100	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	69-73
33308222-12	2020	The mRNA expression of SRD5A1, which encodes an androgen synthesis enzyme, was also upregulated by genipin treatment.	genipin	99-106	steroid 5 alpha-reductase 1	Mus musculus	23-29
33498864-10	2021	We have identified the 0.5 (w/v) genipin concentration as an optimal concentration for improved IL-4 released from the scaffold, cell viability, mechanical strength, and scaffold porosity, and immunomodulation studies.	genipin	33-40	interleukin 4	Homo sapiens	96-100
33446235-11	2021	CONCLUSION: Our study suggests that treatment with genipin in combination with insulin could be an effective method for promoting implant osseointegration in T2DM rats, which may be related to AMPK signaling.	genipin	51-58	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	193-197
32995849-6	2021	RESULTS: Genipin reduced the infection-induced UCP2 levels in macrophages, with optimum effect at 100 muM.	genipin	9-16	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	47-51
33308222-11	2020	The levels of key proteins involved in steroidogenesis, StAR and CYP11A1, were reduced in mouse testes after the circadian disruption, but genipin treatment restored the reduction.	genipin	139-146	steroidogenic acute regulatory protein	Mus musculus	56-60
33308222-13	2020	Furthermore, genipin treatment showed a positive effect on steroidogenesis in MLTC-1 cells, resulting in an increase in hormone secretion and the upregulation of StAR and CYP11A1.	genipin	13-20	steroidogenic acute regulatory protein	Mus musculus	162-166
33308222-13	2020	Furthermore, genipin treatment showed a positive effect on steroidogenesis in MLTC-1 cells, resulting in an increase in hormone secretion and the upregulation of StAR and CYP11A1.	genipin	13-20	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	171-178
33154772-2	2020	We hypothesized that UCP2 may protect cancer cells from elesclomol-induced cytotoxicity, and that this may be overcome by blocking UCP2 function with genipin.	genipin	150-157	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	131-135
33154772-8	2020	The cytotoxic effects of combining genipin and elesclomol were accompanied by reduced mitochondrial membrane potential and occurred through apoptosis as demonstrated by Annexin V assay and increased protein cleavage of PARP and caspase-3.	genipin	35-42	annexin A5	Mus musculus	169-178
33154772-8	2020	The cytotoxic effects of combining genipin and elesclomol were accompanied by reduced mitochondrial membrane potential and occurred through apoptosis as demonstrated by Annexin V assay and increased protein cleavage of PARP and caspase-3.	genipin	35-42	poly (ADP-ribose) polymerase family, member 1	Mus musculus	219-223
33154772-8	2020	The cytotoxic effects of combining genipin and elesclomol were accompanied by reduced mitochondrial membrane potential and occurred through apoptosis as demonstrated by Annexin V assay and increased protein cleavage of PARP and caspase-3.	genipin	35-42	caspase 3	Mus musculus	228-237
33154772-10	2020	Therefore, high UCP2 expression may limit the antitumor effect of elesclomol by attenuating ROS responses, and this may be overcome by co-treatment with genipin; combining elesclomol and genipin may be an effective strategy for treating cancers with high UCP2.	genipin	187-194	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	16-20
31646411-5	2020	DSS-induced MPO activity, MDA level, TNF-alpha, and IL-1beta production in colonic tissues were also suppressed by genipin.	genipin	115-122	myeloperoxidase	Mus musculus	12-15
33126695-6	2020	Scanning electron micrographs revealed a highly porous structure with nanofibrous networks in the CS/PL/BGP/GE hydrogels.	genipin	108-110	citrate synthase	Homo sapiens	98-100
33126695-10	2020	Our findings could suggest that the thermosensitive CS/PL/BGP/GE hydrogels with enhanced mechanical properties and swelling capacity demonstrate the potential for use as scaffolds and carriers for cartilage tissue engineering and drug delivery applications.	genipin	62-64	citrate synthase	Homo sapiens	52-54
33126695-10	2020	Our findings could suggest that the thermosensitive CS/PL/BGP/GE hydrogels with enhanced mechanical properties and swelling capacity demonstrate the potential for use as scaffolds and carriers for cartilage tissue engineering and drug delivery applications.	genipin	62-64	CEA cell adhesion molecule 1	Homo sapiens	58-61
32587130-7	2020	Furthermore, the same genipin concentration inhibited the proliferation of human primary CD4+ T lymphocytes stimulated with CD3/CD28 antibodies by 54.9% +- 8.22%, as evaluated by carboxyfluorescein succinimidyl ester assay.	genipin	22-29	CD4 molecule	Homo sapiens	89-92
32587130-7	2020	Furthermore, the same genipin concentration inhibited the proliferation of human primary CD4+ T lymphocytes stimulated with CD3/CD28 antibodies by 54.9% +- 8.22%, as evaluated by carboxyfluorescein succinimidyl ester assay.	genipin	22-29	CD28 molecule	Homo sapiens	128-132
31646411-5	2020	DSS-induced MPO activity, MDA level, TNF-alpha, and IL-1beta production in colonic tissues were also suppressed by genipin.	genipin	115-122	tumor necrosis factor	Mus musculus	37-46
31646411-5	2020	DSS-induced MPO activity, MDA level, TNF-alpha, and IL-1beta production in colonic tissues were also suppressed by genipin.	genipin	115-122	interleukin 1 beta	Mus musculus	52-60
31646411-7	2020	The results showed genipin significantly attenuated DSS-induced NF-kappaB activation and increased the expression of Nrf2 and HO-1 in a dose-dependent manner.	genipin	19-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
31646411-7	2020	The results showed genipin significantly attenuated DSS-induced NF-kappaB activation and increased the expression of Nrf2 and HO-1 in a dose-dependent manner.	genipin	19-26	heme oxygenase 1	Mus musculus	126-130
31618075-9	2019	Inhibiting UCP2 with genipin sensitized HepG2 cells to palmitoylcarnitine, suggesting that activation of UCP2 may be a 2nd redox-based mechanism conferring protection.	genipin	21-28	uncoupling protein 2	Homo sapiens	11-15
32099325-0	2020	Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway.	genipin	0-7	AKT serine/threonine kinase 1	Homo sapiens	94-97
32099325-0	2020	Genipin Induces Autophagy and Suppresses Cell Growth of Oral Squamous Cell Carcinoma via PI3K/AKT/MTOR Pathway.	genipin	0-7	mechanistic target of rapamycin kinase	Homo sapiens	98-102
31805268-0	2020	Protective effects of genipin on ethanol-induced acute gastric injury in mice by inhibiting NLRP3 inflammasome activation.	genipin	22-29	NLR family, pyrin domain containing 3	Mus musculus	92-97
31885784-5	2019	Moreover, genipin effectively induced the conversion of LC3 and inhibition of p62 accumulation.	genipin	10-17	nucleoporin 62	Mus musculus	78-81
31885784-6	2019	The liver expressions of ATG5, ATG7, and ATG12 were significantly increased by genipin pretreatment in the ALI mice model.	genipin	79-86	autophagy related 5	Mus musculus	25-29
31885784-6	2019	The liver expressions of ATG5, ATG7, and ATG12 were significantly increased by genipin pretreatment in the ALI mice model.	genipin	79-86	autophagy related 7	Mus musculus	31-35
31885784-6	2019	The liver expressions of ATG5, ATG7, and ATG12 were significantly increased by genipin pretreatment in the ALI mice model.	genipin	79-86	autophagy related 12	Mus musculus	41-46
31885784-8	2019	Meanwhile, genipin attenuated CCl4-induced inflammatory response by inhibiting the NF-kappaB and STAT3 signaling pathway.	genipin	11-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
31885784-8	2019	Meanwhile, genipin attenuated CCl4-induced inflammatory response by inhibiting the NF-kappaB and STAT3 signaling pathway.	genipin	11-18	signal transducer and activator of transcription 3	Mus musculus	97-102
31885784-9	2019	In addition, pretreatment with autophagy inhibitor 3-methyladenine (3-MA) or inhibition of p38 MAPK by SB203580 abolished the hepatoprotective effect of genipin.	genipin	153-160	mitogen-activated protein kinase 14	Mus musculus	91-99
31897241-7	2020	Additionally, genipin induced p53 expression in AGS, MKN45, and MKN28 cells.	genipin	14-21	tumor protein p53	Homo sapiens	30-33
31897241-8	2020	Also, genipin induced autophagy and LC3 expression.	genipin	6-13	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	36-39
31897241-9	2020	Knockdown of LC3 decreased cell death enhanced by the combination of oxaliplatin and genipin.	genipin	85-92	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	13-16
31897241-10	2020	In summary, we showed that genipin increases the oxaliplatin-induced cell death via p53-DRAM autophagy.	genipin	27-34	tumor protein p53	Homo sapiens	84-87
31897241-10	2020	In summary, we showed that genipin increases the oxaliplatin-induced cell death via p53-DRAM autophagy.	genipin	27-34	DNA damage regulated autophagy modulator 1	Homo sapiens	88-92
31466050-2	2019	Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway.	genipin	0-7	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	67-113
31605673-0	2019	Genipin, a natural AKT inhibitor, targets the PH domain to affect downstream signaling and alleviates inflammation.	genipin	0-7	AKT serine/threonine kinase 1	Homo sapiens	19-22
31605673-4	2019	In this study, the binding of GNP to AKT protein was demonstrated via a GNP-modified magnetic microspheres (GNP-MMs) capture and immunofluorescence co-localization test.	genipin	30-33	AKT serine/threonine kinase 1	Homo sapiens	37-40
31605673-4	2019	In this study, the binding of GNP to AKT protein was demonstrated via a GNP-modified magnetic microspheres (GNP-MMs) capture and immunofluorescence co-localization test.	genipin	72-75	AKT serine/threonine kinase 1	Homo sapiens	37-40
31605673-4	2019	In this study, the binding of GNP to AKT protein was demonstrated via a GNP-modified magnetic microspheres (GNP-MMs) capture and immunofluorescence co-localization test.	genipin	72-75	AKT serine/threonine kinase 1	Homo sapiens	37-40
31605673-5	2019	GNP-MMs fishing coupled with competitive testing and AKT plasma transport experiments indicate that GNP may act on the PH domain of AKT, and affect AKT plasma transport.	genipin	0-3	AKT serine/threonine kinase 1	Homo sapiens	132-135
31605673-5	2019	GNP-MMs fishing coupled with competitive testing and AKT plasma transport experiments indicate that GNP may act on the PH domain of AKT, and affect AKT plasma transport.	genipin	0-3	AKT serine/threonine kinase 1	Homo sapiens	132-135
31605673-5	2019	GNP-MMs fishing coupled with competitive testing and AKT plasma transport experiments indicate that GNP may act on the PH domain of AKT, and affect AKT plasma transport.	genipin	100-103	AKT serine/threonine kinase 1	Homo sapiens	53-56
31605673-5	2019	GNP-MMs fishing coupled with competitive testing and AKT plasma transport experiments indicate that GNP may act on the PH domain of AKT, and affect AKT plasma transport.	genipin	100-103	AKT serine/threonine kinase 1	Homo sapiens	132-135
31605673-5	2019	GNP-MMs fishing coupled with competitive testing and AKT plasma transport experiments indicate that GNP may act on the PH domain of AKT, and affect AKT plasma transport.	genipin	100-103	AKT serine/threonine kinase 1	Homo sapiens	132-135
31605673-7	2019	The results indicate that GNP targets the PH domain region of AKT, inhibits the phosphorylation of AKT, and attenuates the transduction of AKT based inflammation signal pathway.	genipin	26-29	AKT serine/threonine kinase 1	Homo sapiens	62-65
31605673-7	2019	The results indicate that GNP targets the PH domain region of AKT, inhibits the phosphorylation of AKT, and attenuates the transduction of AKT based inflammation signal pathway.	genipin	26-29	AKT serine/threonine kinase 1	Homo sapiens	99-102
31605673-7	2019	The results indicate that GNP targets the PH domain region of AKT, inhibits the phosphorylation of AKT, and attenuates the transduction of AKT based inflammation signal pathway.	genipin	26-29	AKT serine/threonine kinase 1	Homo sapiens	99-102
31466050-2	2019	Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway.	genipin	0-7	AKT serine/threonine kinase 1	Homo sapiens	139-142
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	nuclear factor kappa B subunit 1	Homo sapiens	94-116
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	nuclear factor kappa B subunit 1	Homo sapiens	118-127
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	tumor necrosis factor	Homo sapiens	162-189
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	tumor necrosis factor	Homo sapiens	191-200
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	interleukin 1 beta	Homo sapiens	203-225
31466050-10	2019	Moreover, genipin pretreatment alleviated LPS-induced inflammation, indicating by blockade of nuclear factor kappa b (NF-kappaB) signaling activation and reduced tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 levels in the lung and bronchoalveolar lavage fluid.	genipin	10-17	interleukin 6	Homo sapiens	231-235
30959368-7	2019	Genipin treatment reduced the expression of P62 and increased the expression of Beclin-1 and LC3II, indicating increased autophagy.	genipin	0-7	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	44-47
31671698-7	2019	Pretreatment of cells with geniposide or genipin increased the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP).	genipin	41-48	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	73-99
31671698-10	2019	Molecular docking simulations were used to investigate the mechanism of FG-induced hepatotoxicity, revealing that geniposide and genipin bind strongly to the pro-inflammatory factor TNFR1 receptor of the NF-kappaB and MAPK signaling pathways.	genipin	129-136	TNF receptor superfamily member 1A	Rattus norvegicus	182-187
31250660-10	2019	Moreover, irisin upregulated UCP2 expression in the pancreas, and administration of genipin, a specific UCP2 antagonist, abolished irisin"s beneficial effects in L-arginine-induced AP.	genipin	84-91	uncoupling protein 2	Homo sapiens	104-108
31250660-10	2019	Moreover, irisin upregulated UCP2 expression in the pancreas, and administration of genipin, a specific UCP2 antagonist, abolished irisin"s beneficial effects in L-arginine-induced AP.	genipin	84-91	fibronectin type III domain containing 5	Homo sapiens	131-137
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	82-89	Janus kinase 2	Homo sapiens	43-57
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	82-89	Janus kinase 2	Homo sapiens	59-63
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	82-89	signal transducer and activator of transcription 3	Homo sapiens	121-126
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	82-89	Janus kinase 2	Homo sapiens	127-131
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	82-89	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	132-137
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	163-170	Janus kinase 2	Homo sapiens	43-57
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	163-170	Janus kinase 2	Homo sapiens	59-63
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	163-170	signal transducer and activator of transcription 3	Homo sapiens	121-126
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	163-170	Janus kinase 2	Homo sapiens	127-131
31351462-11	2019	Additionally, the protein level of phospho Janus kinase 2 (JAK2) was decreased by Genipin treatment, indicating that the Stat3/JAK2/Mcl-1 pathway is suppressed by Genipin treatment in gastric cancer cells.	genipin	163-170	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	132-137
30959368-7	2019	Genipin treatment reduced the expression of P62 and increased the expression of Beclin-1 and LC3II, indicating increased autophagy.	genipin	0-7	beclin 1	Rattus norvegicus	80-88
30959368-7	2019	Genipin treatment reduced the expression of P62 and increased the expression of Beclin-1 and LC3II, indicating increased autophagy.	genipin	0-7	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	93-98
30959368-8	2019	Genipin treatment also alleviated LPS-induced cell apoptosis (down-regulation of Bax, up-regulation of Bcl-2, and decreased number of terminal deoxynucleotidyl transferase dUTP nick end label-positive cells) and oxidative stress (increased SOD and decreased MDA content) in the lung.	genipin	0-7	BCL2 associated X, apoptosis regulator	Rattus norvegicus	81-84
30959368-8	2019	Genipin treatment also alleviated LPS-induced cell apoptosis (down-regulation of Bax, up-regulation of Bcl-2, and decreased number of terminal deoxynucleotidyl transferase dUTP nick end label-positive cells) and oxidative stress (increased SOD and decreased MDA content) in the lung.	genipin	0-7	BCL2, apoptosis regulator	Rattus norvegicus	103-108
30959368-9	2019	Furthermore, genipin attenuated LPS-induced production of TNF-alpha, IL-1beta, and IL-6 in the lung and BALF.	genipin	13-20	tumor necrosis factor	Rattus norvegicus	58-67
30959368-9	2019	Furthermore, genipin attenuated LPS-induced production of TNF-alpha, IL-1beta, and IL-6 in the lung and BALF.	genipin	13-20	interleukin 1 alpha	Rattus norvegicus	69-77
30959368-9	2019	Furthermore, genipin attenuated LPS-induced production of TNF-alpha, IL-1beta, and IL-6 in the lung and BALF.	genipin	13-20	interleukin 6	Rattus norvegicus	83-87
30582911-0	2019	Genipin protects against cerebral ischemia-reperfusion injury by regulating the UCP2-SIRT3 signaling pathway.	genipin	0-7	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	80-84
30988734-5	2019	The administration of genipin, a UCP2 inhibitor, significantly attenuated the effects of miR-214 upregulation on oxidative stress in the in vitro DN model by regulating ROS, Akt and mTOR protein expression levels.	genipin	22-29	uncoupling protein 2	Rattus norvegicus	33-37
30988734-5	2019	The administration of genipin, a UCP2 inhibitor, significantly attenuated the effects of miR-214 upregulation on oxidative stress in the in vitro DN model by regulating ROS, Akt and mTOR protein expression levels.	genipin	22-29	microRNA 214	Rattus norvegicus	89-96
30988734-5	2019	The administration of genipin, a UCP2 inhibitor, significantly attenuated the effects of miR-214 upregulation on oxidative stress in the in vitro DN model by regulating ROS, Akt and mTOR protein expression levels.	genipin	22-29	AKT serine/threonine kinase 1	Rattus norvegicus	174-177
30988734-5	2019	The administration of genipin, a UCP2 inhibitor, significantly attenuated the effects of miR-214 upregulation on oxidative stress in the in vitro DN model by regulating ROS, Akt and mTOR protein expression levels.	genipin	22-29	mechanistic target of rapamycin kinase	Rattus norvegicus	182-186
30787174-0	2019	Genipin Enhances the Therapeutic Effects of Oxaliplatin by Upregulating BIM in Colorectal Cancer.	genipin	0-7	BCL2 like 11	Homo sapiens	72-75
30787174-5	2019	Our study showed that a combination of genipin and oxaliplatin exerts synergistic antitumor effects in vitro and in vivo in colorectal cancer cell lines through the reactive oxygen species (ROS)/endoplasmic reticulum (ER) stress/BIM pathway.	genipin	39-46	BCL2 like 11	Homo sapiens	229-232
30995317-9	2019	Compared to control, treatment with genipin or knockdown of UCP2 significantly increased Glut1, glucose uptake, ATP production, VEGF-induced p-VEGFR2 and cell proliferation in hRMVECs.	genipin	36-43	solute carrier family 2 member 1	Homo sapiens	89-94
30995317-9	2019	Compared to control, treatment with genipin or knockdown of UCP2 significantly increased Glut1, glucose uptake, ATP production, VEGF-induced p-VEGFR2 and cell proliferation in hRMVECs.	genipin	36-43	vascular endothelial growth factor A	Homo sapiens	128-132
30995317-9	2019	Compared to control, treatment with genipin or knockdown of UCP2 significantly increased Glut1, glucose uptake, ATP production, VEGF-induced p-VEGFR2 and cell proliferation in hRMVECs.	genipin	36-43	kinase insert domain receptor	Homo sapiens	143-149
30582911-0	2019	Genipin protects against cerebral ischemia-reperfusion injury by regulating the UCP2-SIRT3 signaling pathway.	genipin	0-7	sirtuin 3	Mus musculus	85-90
30127884-7	2018	Further investigation of genipin-treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase-3 in genipin-treated cells was increased compared with the vehicle control, whereas B-cell lymphoma-2 expression appeared to be lower in genipin-treated cells.	genipin	25-32	tumor protein p53	Homo sapiens	86-89
30569096-11	2019	The results of the present study revealed that Nrf2 silencing attenuated the protective effects of GP on H2O2-induced injury in ARPE-19 cells by promoting apoptosis and oxidation.	genipin	99-101	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
31245957-3	2019	RESULTS: The wet weight of white fat in genipin-treated mice was decreased by 16% , and 28% in that of cold-stimulus mice, compared with the normal control group (P<0.05).After treatments of genipin and cold-stimulus, the color of white adipose tissues was darker, and the size of lipid droplets in adipocytes was smaller, whereas the number was increased.Compared with the normal control group, UCP1 expression was increased obviously in fat tissues, including the subcutaneous and visceral white adipose tissues, and brown adipose tissue after treated with genipin and cold-stimulus (P<0.05).	genipin	40-47	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	399-403
30196116-6	2019	RESULTS: Hyperoxia resulted in the reduction of survival rate and histologic injury of lung tissues; an increase of the messenger RNA (mRNA) expression of transforming growth factor-beta1, extracellular matrix proteins collagen-I and fibronectin, and alpha-smooth muscle actin; an increase of right ventricular (RV) systolic pressure and the weight ratio of RV to left ventriclar (LV) plus septum (S) (RV/LV + S) were inhibited by genipin.	genipin	431-438	transforming growth factor, beta 1	Rattus norvegicus	155-187
30127884-7	2018	Further investigation of genipin-treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase-3 in genipin-treated cells was increased compared with the vehicle control, whereas B-cell lymphoma-2 expression appeared to be lower in genipin-treated cells.	genipin	25-32	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
30127884-7	2018	Further investigation of genipin-treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase-3 in genipin-treated cells was increased compared with the vehicle control, whereas B-cell lymphoma-2 expression appeared to be lower in genipin-treated cells.	genipin	120-127	tumor protein p53	Homo sapiens	86-89
30127884-7	2018	Further investigation of genipin-treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase-3 in genipin-treated cells was increased compared with the vehicle control, whereas B-cell lymphoma-2 expression appeared to be lower in genipin-treated cells.	genipin	120-127	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
30127884-7	2018	Further investigation of genipin-treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase-3 in genipin-treated cells was increased compared with the vehicle control, whereas B-cell lymphoma-2 expression appeared to be lower in genipin-treated cells.	genipin	120-127	tumor protein p53	Homo sapiens	86-89
30127884-7	2018	Further investigation of genipin-treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase-3 in genipin-treated cells was increased compared with the vehicle control, whereas B-cell lymphoma-2 expression appeared to be lower in genipin-treated cells.	genipin	120-127	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
29784903-7	2018	L-NAME, tunicamycin, and Genipin attenuated vasodilation in WT, WT-EX and ApoE KO-EX, but not in ApoE KO.	genipin	25-32	apolipoprotein E	Mus musculus	74-78
30160798-1	2018	Genipin, a compound derived from Gardenis jasminoides Ellis fruits, was demonstrated to be the specific uncoupling protein 2 (UCP2) inhibitor.	genipin	0-7	uncoupling protein 2	Homo sapiens	104-124
30160798-1	2018	Genipin, a compound derived from Gardenis jasminoides Ellis fruits, was demonstrated to be the specific uncoupling protein 2 (UCP2) inhibitor.	genipin	0-7	uncoupling protein 2	Homo sapiens	126-130
30160798-13	2018	Flow cytometric analysis of U87MG and A172 cells with annexin V/propidium iodide staining, 48 hours after treatment with genipin, displays 22.4% and 26.1% apoptotic population, respectively, in treated cells, in comparison to 7.42% and 9.31% apoptotic cells of untreated cells.	genipin	121-128	annexin A5	Homo sapiens	54-63
28738532-4	2017	GP pretreatment attenuated the CP-induced renal tissue injury by diminishing the serum blood urea nitrogen, creatinine, and cystatin C levels, as well as those of kidney injury molecule-1.	genipin	0-2	cystatin C	Homo sapiens	124-134
29434982-5	2018	The involvement of the phosphoinositide-3 kinase (PI3K)/Akt pathway in the action of genipin was examined.	genipin	85-92	AKT serine/threonine kinase 1	Homo sapiens	56-59
28962872-5	2017	The synthetic compound (S)-benzyl-2-amino-2-(S)-3-bromo-4,5-dihydroisoxazol-5-yl-acetate (AXP3009), which binds GAPDH at its redox-sensitive Cys152, restores cell viability affected by the combined treatment with genipin and everolimus, suggesting a role for ROS production in the nuclear translocation of GAPDH.	genipin	213-220	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	112-117
29035815-7	2017	Additionally, genipin inhibited OVA-induced increases in the expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins.	genipin	14-21	prostaglandin-endoperoxide synthase 2	Mus musculus	111-127
29135040-8	2017	The serum levels of IFN-gamma, IL-1beta, immunoglobulin A, and Immunoglobulin M were decreased by geniposide and genipin in infected mice.	genipin	113-120	interferon gamma	Mus musculus	20-29
29135040-8	2017	The serum levels of IFN-gamma, IL-1beta, immunoglobulin A, and Immunoglobulin M were decreased by geniposide and genipin in infected mice.	genipin	113-120	interleukin 1 beta	Mus musculus	31-39
29547569-6	2018	Consistently, genipin, a pharmacologic inhibitor of UCP2, augmented LPS-induced damage of AC16 cells.	genipin	14-21	uncoupling protein 2	Homo sapiens	52-56
28089824-1	2017	To explore the roles of mitochondrial Uncoupling Protein 2 (UCP2) in cumulus cells (CCs), human CCs were cultured in vitro, and the UCP2 was inhibited by treatment with Genipin, a special UCP inhibitor, or by RNA interference targeting UCP2.	genipin	169-176	uncoupling protein 2	Homo sapiens	132-136
31966895-0	2017	Effects of mitochondrial uncoupling protein 2 inhibition by Genipin on rat bone marrow mesenchymal stem cells under hypoxia and serum deprivation (H/SD) conditions.	genipin	60-67	uncoupling protein 2	Rattus norvegicus	11-45
31966895-7	2017	Genipin, a special UCP2 inhibitor, was added into the cultural medium to reduce the UCP2 expression in BMSCs.	genipin	0-7	uncoupling protein 2	Rattus norvegicus	19-23
31966895-7	2017	Genipin, a special UCP2 inhibitor, was added into the cultural medium to reduce the UCP2 expression in BMSCs.	genipin	0-7	uncoupling protein 2	Rattus norvegicus	84-88
31966895-12	2017	In addition, Bax and caspase3 activation were elevated after treatment with Genipin (P<0.05).	genipin	76-83	BCL2 associated X, apoptosis regulator	Rattus norvegicus	13-16
31966895-12	2017	In addition, Bax and caspase3 activation were elevated after treatment with Genipin (P<0.05).	genipin	76-83	caspase 3	Rattus norvegicus	21-29
31966895-13	2017	However, the level of anti-apoptotic protein Bcl2 was significantly declined after treatment with Genipin (P<0.05).	genipin	98-105	BCL2, apoptosis regulator	Rattus norvegicus	45-49
31966895-14	2017	Taken together, our findings indicate that inhibitionof UCP2 by Genipin enhanced the BMSCs apoptosis under H/SD conditions.	genipin	64-71	uncoupling protein 2	Rattus norvegicus	56-60
28089824-1	2017	To explore the roles of mitochondrial Uncoupling Protein 2 (UCP2) in cumulus cells (CCs), human CCs were cultured in vitro, and the UCP2 was inhibited by treatment with Genipin, a special UCP inhibitor, or by RNA interference targeting UCP2.	genipin	169-176	uncoupling protein 2	Homo sapiens	132-136
28089824-5	2017	The mRNA and protein expression of connexin 43 (Cx43), a gap junction channel protein, were significantly reduced after treatment with Genipin or siRNA.	genipin	135-142	gap junction protein alpha 1	Homo sapiens	35-46
28089824-5	2017	The mRNA and protein expression of connexin 43 (Cx43), a gap junction channel protein, were significantly reduced after treatment with Genipin or siRNA.	genipin	135-142	gap junction protein alpha 1	Homo sapiens	48-52
29049992-10	2017	Though only genipin showed an efficient ability to scavenge O2-, the iridoids, IkappaB inhibitor (BAY 11-7085), and NF-kappaB inhibitor (PDTC) could inhibit LPS-induced oxidative stress on the cells, indicating that the iridoids exert their anti-oxidant effects via the NF-kappaB pathway.	genipin	12-19	nuclear factor kappa B subunit 1	Homo sapiens	116-125
29049992-10	2017	Though only genipin showed an efficient ability to scavenge O2-, the iridoids, IkappaB inhibitor (BAY 11-7085), and NF-kappaB inhibitor (PDTC) could inhibit LPS-induced oxidative stress on the cells, indicating that the iridoids exert their anti-oxidant effects via the NF-kappaB pathway.	genipin	12-19	nuclear factor kappa B subunit 1	Homo sapiens	270-279
27774888-0	2017	Genipin Inhibits the Induction of Inducible Nitric Oxide Synthase Through the Inhibition of NF-kappaB Activation in Rat Hepatocytes.	genipin	0-7	nitric oxide synthase 2	Rattus norvegicus	34-65
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	15-22	DNA methyltransferase 1	Homo sapiens	87-123
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	15-22	DNA methyltransferase 1	Homo sapiens	125-130
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	15-22	DNA methyltransferase 1	Homo sapiens	189-194
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	15-22	LANA	Human gammaherpesvirus 8	199-203
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	215-222	DNA methyltransferase 1	Homo sapiens	87-123
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	215-222	DNA methyltransferase 1	Homo sapiens	125-130
27736870-12	2016	Interestingly, genipin treatment at a lower concentration did induce the expression of DNA (cytosine-5)-methyltransferase 1 (DNMT1); however, a co-immunoprecipitation assay showed that the DNMT1 and LANA induced by genipin did not co-precipitate from iSLK-BAC16 cells.	genipin	215-222	DNA methyltransferase 1	Homo sapiens	189-194
27465745-5	2016	Using a fluorogenic peptide assay, MMP activity was increased with BAPN treatment, but reduced with genipin treatment.	genipin	100-107	matrix metallopeptidase 2	Homo sapiens	35-38
27343367-5	2016	The effects of genipin on Ang II-induced activation of the MAPK pathway and up-regulation of TLR2, TLR4, and MyD88 were detected by real-time PCR and Western blot and further validated in MyD88 siRNA-transfected HMCs.	genipin	15-22	angiotensinogen	Rattus norvegicus	26-32
27270308-7	2016	This is revealed by the in vivo deletion of IRE1alpha on TAMs in genipin-treated HCC-implanted mice.	genipin	65-72	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	44-53
27343367-5	2016	The effects of genipin on Ang II-induced activation of the MAPK pathway and up-regulation of TLR2, TLR4, and MyD88 were detected by real-time PCR and Western blot and further validated in MyD88 siRNA-transfected HMCs.	genipin	15-22	toll-like receptor 2	Rattus norvegicus	93-97
27343367-5	2016	The effects of genipin on Ang II-induced activation of the MAPK pathway and up-regulation of TLR2, TLR4, and MyD88 were detected by real-time PCR and Western blot and further validated in MyD88 siRNA-transfected HMCs.	genipin	15-22	toll-like receptor 4	Rattus norvegicus	99-103
27343367-5	2016	The effects of genipin on Ang II-induced activation of the MAPK pathway and up-regulation of TLR2, TLR4, and MyD88 were detected by real-time PCR and Western blot and further validated in MyD88 siRNA-transfected HMCs.	genipin	15-22	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	109-114
27343367-5	2016	The effects of genipin on Ang II-induced activation of the MAPK pathway and up-regulation of TLR2, TLR4, and MyD88 were detected by real-time PCR and Western blot and further validated in MyD88 siRNA-transfected HMCs.	genipin	15-22	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	188-193
27343367-5	2016	The effects of genipin on Ang II-induced activation of the MAPK pathway and up-regulation of TLR2, TLR4, and MyD88 were detected by real-time PCR and Western blot and further validated in MyD88 siRNA-transfected HMCs.	genipin	15-22	MKKS centrosomal shuttling protein	Homo sapiens	212-216
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	genipin	13-20	interleukin 1 beta	Homo sapiens	97-115
26660048-12	2016	CLP impaired autophagic flux, as indicated by increased liver expression of microtubule-associated protein-1 light chain 3-II and sequestosome-1/p62 protein; this impaired autophagic flux was restored by genipin, and chloroquine abolished this effect.	genipin	204-211	hyaluronan and proteoglycan link protein 1	Mus musculus	0-3
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	genipin	13-20	interleukin 1 beta	Homo sapiens	117-125
26123077-7	2015	In addition, genipin altered adenosine triphosphate (ATP)- and hydrogen peroxide (H2O2)-mediated interleukin-1 beta (IL-1beta) secretion and significantly suppressed caspase-1 activity in inflammasome-activated human macrophages.	genipin	13-20	caspase 1	Homo sapiens	166-175
24972301-9	2014	The mRNA expressions of 5-hydroxytryptamine 1A receptor (5-HT1AR), cAMP response element binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in rats were decreased exposed to CUMS, which were reversed by genipin-treated rats exposed to CUMS.	genipin	220-227	brain-derived neurotrophic factor	Rattus norvegicus	151-155
25457105-5	2014	Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-alpha-stimulated HPDLCs.	genipin	10-17	mitogen-activated protein kinase 1	Homo sapiens	42-79
25457105-5	2014	Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-alpha-stimulated HPDLCs.	genipin	10-17	mitogen-activated protein kinase 1	Homo sapiens	81-84
25457105-5	2014	Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-alpha-stimulated HPDLCs.	genipin	10-17	mitogen-activated protein kinase 8	Homo sapiens	90-111
25457105-5	2014	Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-alpha-stimulated HPDLCs.	genipin	10-17	mitogen-activated protein kinase 8	Homo sapiens	113-116
25457105-5	2014	Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-alpha-stimulated HPDLCs.	genipin	10-17	tumor necrosis factor	Homo sapiens	199-208
24413982-8	2014	Treatment with resveratrol and genipin up-regulated NQO1 and HMOX1 expression and reduced oxidative stress in patients" lymphoblastoid cells.	genipin	31-38	NAD(P)H quinone dehydrogenase 1	Homo sapiens	52-56
24964191-3	2014	In this study, we found that genipin, a UCP2 inhibitor, dramatically boosted oxidative stress, attenuated antioxidative capacity, and exacerbated cell apoptosis accompanied with caspase-3 activation in rat renal proximal tubular cells (NRK-52E) incubated with high glucose.	genipin	29-36	uncoupling protein 2	Rattus norvegicus	40-44
24964191-3	2014	In this study, we found that genipin, a UCP2 inhibitor, dramatically boosted oxidative stress, attenuated antioxidative capacity, and exacerbated cell apoptosis accompanied with caspase-3 activation in rat renal proximal tubular cells (NRK-52E) incubated with high glucose.	genipin	29-36	caspase 3	Rattus norvegicus	178-187
24413982-8	2014	Treatment with resveratrol and genipin up-regulated NQO1 and HMOX1 expression and reduced oxidative stress in patients" lymphoblastoid cells.	genipin	31-38	heme oxygenase 1	Homo sapiens	61-66
24413982-10	2014	Compounds increasing anti-oxidative activity such as resveratrol and genipin may serve as a potential therapeutic strategy for SCA17.	genipin	69-76	ataxin 7	Homo sapiens	127-132
24486383-3	2014	Here we show the anti-aggregation potential of Gardenia jasminoides (G. jasminoides) and its components/metabolite geniposide, crocin, and genipin, in ATXN3/Q75-GFP 293 cells, a putative SCA3 cell model.	genipin	139-146	ataxin 3	Homo sapiens	151-156
24009871-7	2013	On the other hand, increased hepatic heme oxygenase-1 protein expression was potentiated by geniposide and genipin administration.	genipin	107-114	heme oxygenase 1	Mus musculus	37-53
24296130-0	2014	Genipin induces cyclooxygenase-2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in RAW 264.7 cells.	genipin	0-7	prostaglandin-endoperoxide synthase 2	Mus musculus	16-32
24296130-0	2014	Genipin induces cyclooxygenase-2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in RAW 264.7 cells.	genipin	0-7	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-89
24296130-5	2014	Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression.	genipin	81-88	thymoma viral proto-oncogene 1	Mus musculus	30-33
24296130-5	2014	Phosphatidylinositol-3-kinase/Akt and MAPKs were also significantly activated by genipin, and Akt and MAPKs inhibitors (PD98059, SB20358, SP600125, and LY294002) inhibited genipin-induced COX-2 expression.	genipin	81-88	prostaglandin-endoperoxide synthase 2	Mus musculus	188-193
24009871-8	2013	The increased levels of tBid, cytochrome c protein expression and caspase-3 activity were attenuated by geniposide and genipin.	genipin	119-126	caspase 3	Mus musculus	66-75
21935467-13	2011	In summary, our studies demonstrate that i) the Warburg Effect is mediated by UCP2; ii) UCP2 is over-expressed in breast and many other cancers; iii) UCP2 promotes tumorigenic properties in vitro and in vivo and iv) genipin suppresses the tumor promoting function of UCP2.	genipin	216-223	uncoupling protein 2	Homo sapiens	88-92
21399655-11	2011	After stimulation with genipin 500 mumol/L, the levels of p-JNK, p-c-Jun, Fas-L, Bax, and cytochrome c were remarkably upregulated, but there were no obvious changes of p-p38.	genipin	23-30	mitogen-activated protein kinase 8	Homo sapiens	60-63
21399655-11	2011	After stimulation with genipin 500 mumol/L, the levels of p-JNK, p-c-Jun, Fas-L, Bax, and cytochrome c were remarkably upregulated, but there were no obvious changes of p-p38.	genipin	23-30	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	67-72
21399655-11	2011	After stimulation with genipin 500 mumol/L, the levels of p-JNK, p-c-Jun, Fas-L, Bax, and cytochrome c were remarkably upregulated, but there were no obvious changes of p-p38.	genipin	23-30	Fas ligand	Homo sapiens	74-79
21399655-11	2011	After stimulation with genipin 500 mumol/L, the levels of p-JNK, p-c-Jun, Fas-L, Bax, and cytochrome c were remarkably upregulated, but there were no obvious changes of p-p38.	genipin	23-30	BCL2 associated X, apoptosis regulator	Homo sapiens	81-84
21399655-11	2011	After stimulation with genipin 500 mumol/L, the levels of p-JNK, p-c-Jun, Fas-L, Bax, and cytochrome c were remarkably upregulated, but there were no obvious changes of p-p38.	genipin	23-30	cytochrome c, somatic	Homo sapiens	90-102
21399655-11	2011	After stimulation with genipin 500 mumol/L, the levels of p-JNK, p-c-Jun, Fas-L, Bax, and cytochrome c were remarkably upregulated, but there were no obvious changes of p-p38.	genipin	23-30	mitogen-activated protein kinase 14	Homo sapiens	171-174
22736029-9	2012	Restoration of mitochondrial membrane potential by the UCP inhibitor genipin confirmed the role of UCPs in this mechanism.	genipin	69-76	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	55-58
21935467-13	2011	In summary, our studies demonstrate that i) the Warburg Effect is mediated by UCP2; ii) UCP2 is over-expressed in breast and many other cancers; iii) UCP2 promotes tumorigenic properties in vitro and in vivo and iv) genipin suppresses the tumor promoting function of UCP2.	genipin	216-223	uncoupling protein 2	Homo sapiens	88-92
21935467-13	2011	In summary, our studies demonstrate that i) the Warburg Effect is mediated by UCP2; ii) UCP2 is over-expressed in breast and many other cancers; iii) UCP2 promotes tumorigenic properties in vitro and in vivo and iv) genipin suppresses the tumor promoting function of UCP2.	genipin	216-223	uncoupling protein 2	Homo sapiens	88-92
21374988-0	2010	[Influence of genipin and vitamin E on UCP2 and other correlation factors in non-alcoholic fatty liver disease].	genipin	14-21	uncoupling protein 2	Homo sapiens	39-43
20967268-0	2010	Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents.	genipin	0-7	uncoupling protein 2	Homo sapiens	30-50
20967268-2	2010	Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subline as model systems, we show that genipin, a UCP2 inhibitor, sensitizes drug-resistant cells to cytotoxic agents.	genipin	103-110	MX dynamin like GTPase 2	Homo sapiens	60-63
20967268-2	2010	Using the drug-sensitive HL-60 cells and the drug-resistant MX2 subline as model systems, we show that genipin, a UCP2 inhibitor, sensitizes drug-resistant cells to cytotoxic agents.	genipin	103-110	uncoupling protein 2	Homo sapiens	114-118
17707342-1	2007	It has been reported that genipin, the aglycone of geniposide, induces apoptotic cell death in human hepatoma cells via a NADPH oxidase-reactive oxygen species (ROS)-c-Jun NH(2)-terminal kinase (JNK)-dependent activation of mitochondrial pathway.	genipin	26-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-171
20686229-0	2010	Genipin induced apoptosis associated with activation of the c-Jun NH2-terminal kinase and p53 protein in HeLa cells.	genipin	0-7	tumor protein p53	Homo sapiens	90-93
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	mitogen-activated protein kinase 8	Homo sapiens	84-87
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	tumor protein p53	Homo sapiens	119-122
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	BCL2 associated X, apoptosis regulator	Homo sapiens	135-138
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	mitogen-activated protein kinase 8	Homo sapiens	275-278
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	tumor protein p53	Homo sapiens	315-318
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	tumor protein p53	Homo sapiens	315-318
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	BCL2 associated X, apoptosis regulator	Homo sapiens	397-400
20686229-8	2010	Western blot analysis revealed that the phosphorylated c-Jun NH(2)-terminal kinase (JNK) protein, phospho-Jun protein, p53 protein and bax protein significantly increased in a dose-dependent manner after treatment of genipin for 24 h, and to our knowledge, the activation of JNK maybe result in the increase of the p53 protein level, and the increase of the p53 protein led to the accumulation of bax protein, bax protein further induced cell apoptotic death eventually.	genipin	217-224	BCL2 associated X, apoptosis regulator	Homo sapiens	397-400
18070051-1	2008	AIM: Genipin, a metabolite of geniposide, is reported to stimulate the insertion of multidrug resistance protein 2 (Mrp2) in the bile canalicular membrane, and to cause choleresis by increasing the biliary excretion of glutathione, which has been considered to be a substrate of Mrp2.	genipin	5-12	ATP binding cassette subfamily B member 4	Rattus norvegicus	84-114
18070051-1	2008	AIM: Genipin, a metabolite of geniposide, is reported to stimulate the insertion of multidrug resistance protein 2 (Mrp2) in the bile canalicular membrane, and to cause choleresis by increasing the biliary excretion of glutathione, which has been considered to be a substrate of Mrp2.	genipin	5-12	ATP binding cassette subfamily B member 4	Rattus norvegicus	116-120
18070051-1	2008	AIM: Genipin, a metabolite of geniposide, is reported to stimulate the insertion of multidrug resistance protein 2 (Mrp2) in the bile canalicular membrane, and to cause choleresis by increasing the biliary excretion of glutathione, which has been considered to be a substrate of Mrp2.	genipin	5-12	ATP binding cassette subfamily B member 4	Rattus norvegicus	279-283
20465544-10	2010	UCP2 (uncoupling protein 2) expression was reduced in RIPCre alpha2KO islets and the UCP2 inhibitor genipin suppressed low-glucose-mediated wild-type mouse beta-cell hyperpolarization, mimicking the effect of AMPK alpha2 loss.	genipin	100-107	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	85-89
17707342-1	2007	It has been reported that genipin, the aglycone of geniposide, induces apoptotic cell death in human hepatoma cells via a NADPH oxidase-reactive oxygen species (ROS)-c-Jun NH(2)-terminal kinase (JNK)-dependent activation of mitochondrial pathway.	genipin	26-33	mitogen-activated protein kinase 8	Homo sapiens	195-198
16297660-11	2005	TNF-alpha, NF-kappaB activation and TNF-alpha mRNA expression in a cultured mouse macrophage-like cell line J774.1 were significantly suppressed by genipin administration.	genipin	148-155	tumor necrosis factor	Mus musculus	0-9
17038627-5	2007	Mrp2 protein and mRNA levels and Mrp2 membrane densities in the bile canaliculi and renal proximal tubules were significantly increased in ICKT- or genipin-treated rat livers and kidneys.	genipin	148-155	ATP binding cassette subfamily C member 2	Rattus norvegicus	0-4
17038627-5	2007	Mrp2 protein and mRNA levels and Mrp2 membrane densities in the bile canaliculi and renal proximal tubules were significantly increased in ICKT- or genipin-treated rat livers and kidneys.	genipin	148-155	ATP binding cassette subfamily C member 2	Rattus norvegicus	33-37
16239071-8	2006	On the other hand, NGF-primed PC12 cells exhibited significant neurite extension, which was inhibited by L-NAME, in response to genipin.	genipin	128-135	nerve growth factor	Rattus norvegicus	19-22
16297660-11	2005	TNF-alpha, NF-kappaB activation and TNF-alpha mRNA expression in a cultured mouse macrophage-like cell line J774.1 were significantly suppressed by genipin administration.	genipin	148-155	tumor necrosis factor	Mus musculus	36-45
34944525-5	2021	Evodiamine, berberine, genipin, palmitic acid, genistein, and quercetin were shown to regulate adipocytokine signaling pathway proteins which mainly involved tumor necrosis factor receptor 1, leptin receptor.	genipin	23-30	leptin receptor	Homo sapiens	192-207
16143311-2	2005	Here we demonstrate that genipin induces apoptotic cell death in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells, detected by morphological cellular changes, caspase activation and release of cytochrome c.	genipin	25-32	cytochrome c, somatic	Homo sapiens	205-217
16143311-3	2005	During genipin-induced apoptosis, reactive oxygen species (ROS) level was elevated, and N-acetyl-l-cysteine (NAC) and glutathione (GSH) suppressed activation of caspase-3, -7 and -9.	genipin	7-14	caspase 3	Rattus norvegicus	161-181
16143311-4	2005	Stress-activated protein kinase/c-Jun NH2-terminal kinase 1/2(SAPK/JNK1/2) but neither MEK1/2 nor p38 MAPK was activated in genipin-treated hepatoma cells.	genipin	124-131	mitogen-activated protein kinase 9	Rattus norvegicus	62-66
16143311-5	2005	SP600125, an SAPK/JNK1/2 inhibitor, markedly suppressed apoptotic cell death in the genipin-treated cells.	genipin	84-91	mitogen-activated protein kinase 9	Rattus norvegicus	13-17
16143311-8	2005	Consistently, the stable expression of Nox1-C, a C-terminal region of Nox1 unable to generate ROS, blocked the formation of TUNEL-positive apoptotic cells, and activation of caspase-3 and JNK in FaO cells treated with genipin.	genipin	218-225	NADPH oxidase 1	Rattus norvegicus	39-43
14752835-3	2004	Biliary secretion of Mrp2 substrates and the protein mass, subcellular localization, and messenger RNA (mRNA) level of Mrp2 were assessed in rat liver after infusion of genipin, an intestinal bacterial metabolite of geniposide, a major ingredient of ICKT.	genipin	169-176	ATP binding cassette subfamily C member 2	Rattus norvegicus	119-123
34807408-7	2022	Genipin pre-treatment reduced the aforementioned I/R injury in the HtrA2Hetero brain cortex.	genipin	0-7	HtrA serine peptidase 2	Mus musculus	67-72
34146128-10	2021	Moreover, UCP-2 inhibitor Genipin significantly enhanced the proliferation suppression effects of trastuzumab and markedly promoted apoptosis.	genipin	26-33	uncoupling protein 2	Homo sapiens	10-15
34658794-4	2021	Additionally, an inhibitor of UCP2 (genipin) was administered to investigate the underlying mechanism of irisin-induced neuroprotection; in rats treated with genipin, the neuroprotective effects of irisin on KA-induced SE were found to be partially reversed.	genipin	36-43	uncoupling protein 2	Rattus norvegicus	30-34
34198010-4	2021	Based on the pH-dependent reactivity of genipin, genipin-terminated 4 arm-poly(ethylene glycol) (GeniPEG) was synthesized.	genipin	40-47	phenylalanine hydroxylase	Homo sapiens	13-15
34198010-4	2021	Based on the pH-dependent reactivity of genipin, genipin-terminated 4 arm-poly(ethylene glycol) (GeniPEG) was synthesized.	genipin	49-56	phenylalanine hydroxylase	Homo sapiens	13-15
34332844-18	2021	Butyrate showed detoxification on genipin-induced liver injury by promoting colon integrity and promoting Nrf2 activation.	genipin	34-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
34332844-19	2021	Besides, it protected genipin-induced hepatocyte damage by promoting Nrf2 activation.	genipin	22-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	69-73
34086366-7	2021	It was found that the levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine, and urea nitrogen increased following administration of FG, geniposide, and genipin.	genipin	196-203	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	32-58
35603420-5	2022	The uncoupling protein inhibitor genipin reversed the increased 18F-FDG uptake and greater OCR of CD133(+) cells.	genipin	33-40	prominin 1	Homo sapiens	98-103
35603420-7	2022	However, cotreatment of CD133(+) cells with genipin and piperlongumine efficiently stimulated mitochondrial ROS for an enhanced antitumor effect with substantially reduced CD133 expression.	genipin	44-51	prominin 1	Homo sapiens	24-29
35603420-7	2022	However, cotreatment of CD133(+) cells with genipin and piperlongumine efficiently stimulated mitochondrial ROS for an enhanced antitumor effect with substantially reduced CD133 expression.	genipin	44-51	prominin 1	Homo sapiens	172-177
35409033-3	2022	In this study, HK-2 cells were treated with different concentrations of AA I with or without UCP2 inhibitor (genipin).	genipin	109-116	uncoupling protein 2	Homo sapiens	93-97