PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33811696-8	2021	The antagonist (CH223191) and siAhR of aryl hydrocarbon receptor (AhR) nearly completely diminished the effects of tetrandrine, including inhibition of the miR429 expression, the upregulation of Occludin expression, and amelioration of intestinal epithelial barrier defects in Caco-2 cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-24	microRNA 429	Homo sapiens	156-162
33811696-8	2021	The antagonist (CH223191) and siAhR of aryl hydrocarbon receptor (AhR) nearly completely diminished the effects of tetrandrine, including inhibition of the miR429 expression, the upregulation of Occludin expression, and amelioration of intestinal epithelial barrier defects in Caco-2 cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-24	occludin	Homo sapiens	195-203
33811696-9	2021	In colitis mice, CH223191 significantly weakened the protective effect of tetrandrine on colitis and intestinal mucosal barrier and diminished the downregulation on miR-429 expression and the promotion on Occludin expression in the colon.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	17-25	microRNA 429	Mus musculus	165-172
33811696-9	2021	In colitis mice, CH223191 significantly weakened the protective effect of tetrandrine on colitis and intestinal mucosal barrier and diminished the downregulation on miR-429 expression and the promotion on Occludin expression in the colon.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	17-25	occludin	Mus musculus	205-213
33804845-6	2021	MCAO increased the expression of tumor necrosis factor alpha (TNFalpha) and then induced edema progression, and worsened the modified neurological severity scores, with these being suppressed by administration of an AhR antagonist, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	232-240	tumor necrosis factor	Mus musculus	33-60
33804845-6	2021	MCAO increased the expression of tumor necrosis factor alpha (TNFalpha) and then induced edema progression, and worsened the modified neurological severity scores, with these being suppressed by administration of an AhR antagonist, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	232-240	tumor necrosis factor	Mus musculus	62-70
33804845-6	2021	MCAO increased the expression of tumor necrosis factor alpha (TNFalpha) and then induced edema progression, and worsened the modified neurological severity scores, with these being suppressed by administration of an AhR antagonist, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	232-240	aryl-hydrocarbon receptor	Mus musculus	216-219
33766215-6	2021	The AhR antagonist CH-223191 abrogated the observed effects of Cd on the cytokine response.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	aryl hydrocarbon receptor	Rattus norvegicus	4-7
34944003-7	2021	Furthermore, blockade of AhR signaling through CH223191, an AhR antagonist, and knockdown of AhR expression reversed Kyn-induced inhibition of osteoclast differentiation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	47-55	aryl hydrocarbon receptor	Homo sapiens	25-28
33232689-7	2021	The increase was suppressed by addition of the NADPH oxidase inhibitor apocynin, the antioxidant ascorbic acid and the aryl hydrocarbon receptor (AhR) inhibitor CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	161-169	aryl hydrocarbon receptor	Rattus norvegicus	119-144
33232689-7	2021	The increase was suppressed by addition of the NADPH oxidase inhibitor apocynin, the antioxidant ascorbic acid and the aryl hydrocarbon receptor (AhR) inhibitor CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	161-169	aryl hydrocarbon receptor	Rattus norvegicus	146-149
34944003-7	2021	Furthermore, blockade of AhR signaling through CH223191, an AhR antagonist, and knockdown of AhR expression reversed Kyn-induced inhibition of osteoclast differentiation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	47-55	aryl hydrocarbon receptor	Homo sapiens	60-63
35123286-5	2022	However, these effects of acteoside on DCs were reversed by pretreatment with CH223191, an aryl hydrocarbon receptor (AhR) antagonist.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	78-86	aryl-hydrocarbon receptor	Mus musculus	91-116
34915497-8	2022	Interestingly, this induction was eliminated by co-treatment with an AhR antagonist, CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	85-94	aryl-hydrocarbon receptor	Mus musculus	69-72
34868022-5	2021	AhR regulation of Muc5ac expression, mitochondrial ROS (Mito-ROS) generation, and NLRP3 inflammasome was determined by AhR knockdown, the antagonist CH223191, and AhR-/- mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	149-157	aryl-hydrocarbon receptor	Mus musculus	0-3
34868022-10	2021	Moreover, cockroach allergen induced epithelial NLRP3 inflammasome activation (e.g., NLRP3, Caspase-1, and IL-1beta), which was enhanced by AhR knockdown or the antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	NLR family, pyrin domain containing 3	Mus musculus	48-53
34868022-10	2021	Moreover, cockroach allergen induced epithelial NLRP3 inflammasome activation (e.g., NLRP3, Caspase-1, and IL-1beta), which was enhanced by AhR knockdown or the antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	NLR family, pyrin domain containing 3	Mus musculus	85-90
34868022-10	2021	Moreover, cockroach allergen induced epithelial NLRP3 inflammasome activation (e.g., NLRP3, Caspase-1, and IL-1beta), which was enhanced by AhR knockdown or the antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	caspase 1	Mus musculus	92-101
34868022-10	2021	Moreover, cockroach allergen induced epithelial NLRP3 inflammasome activation (e.g., NLRP3, Caspase-1, and IL-1beta), which was enhanced by AhR knockdown or the antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	interleukin 1 alpha	Mus musculus	107-115
34778104-6	2021	Using the specific inhibitor CH223191, we showed that the induction of CYP1A was dependent on the AhR both in vitro using multiple CRC cell lines as in vivo using wild-type C57bl6 mice colonized with S. gallolyticus.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	aryl-hydrocarbon receptor	Mus musculus	98-101
34146985-7	2021	We found increased expression of AhR and decreased downstream targets of CYP 1A1 and CYP 1B1 in BDE-47-treated HEI-OC1 cells, which was reversed by the AhR antagonist CH-223191 for 2 h before BDE-47 exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	167-176	aryl hydrocarbon receptor	Homo sapiens	33-36
34146985-7	2021	We found increased expression of AhR and decreased downstream targets of CYP 1A1 and CYP 1B1 in BDE-47-treated HEI-OC1 cells, which was reversed by the AhR antagonist CH-223191 for 2 h before BDE-47 exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	167-176	homeobox D13	Homo sapiens	96-99
34146985-7	2021	We found increased expression of AhR and decreased downstream targets of CYP 1A1 and CYP 1B1 in BDE-47-treated HEI-OC1 cells, which was reversed by the AhR antagonist CH-223191 for 2 h before BDE-47 exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	167-176	aryl hydrocarbon receptor	Homo sapiens	152-155
34134959-5	2021	OBJECTIVE: Both TCDD and CH223191 were capable of modulating pulmonary expressions of AhR and its downstream genes Cyp1a1 and Cyp1b1 in asthmatic mice (P < 0.002).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	25-33	aryl-hydrocarbon receptor	Mus musculus	86-89
34134959-5	2021	OBJECTIVE: Both TCDD and CH223191 were capable of modulating pulmonary expressions of AhR and its downstream genes Cyp1a1 and Cyp1b1 in asthmatic mice (P < 0.002).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	25-33	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	115-121
34134959-5	2021	OBJECTIVE: Both TCDD and CH223191 were capable of modulating pulmonary expressions of AhR and its downstream genes Cyp1a1 and Cyp1b1 in asthmatic mice (P < 0.002).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	25-33	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	126-132
34938989-4	2022	In this study, we constructed a polypeptide-based micellar system that encapsulates an aryl hydrocarbon receptor (AhR) inhibitor (CH223191) conjugated to T cell activator anti-CD28.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	130-138	aryl hydrocarbon receptor	Homo sapiens	87-112
34938989-4	2022	In this study, we constructed a polypeptide-based micellar system that encapsulates an aryl hydrocarbon receptor (AhR) inhibitor (CH223191) conjugated to T cell activator anti-CD28.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	130-138	aryl hydrocarbon receptor	Homo sapiens	114-117
34938989-4	2022	In this study, we constructed a polypeptide-based micellar system that encapsulates an aryl hydrocarbon receptor (AhR) inhibitor (CH223191) conjugated to T cell activator anti-CD28.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	130-138	CD28 molecule	Homo sapiens	176-180
34597721-3	2021	Here, we found that BaP increased heart malformations in zebrafish embryos in a concentration-dependent manner, which were attenuated by supplementation with either CH223191 (CH), an aryl hydrocarbon receptor (AHR) inhibitor, or N-acetyl-l-cysteine (NAC), a reactive oxygen species (ROS) scavenger.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	165-173	aryl hydrocarbon receptor 1a	Danio rerio	183-208
34597721-3	2021	Here, we found that BaP increased heart malformations in zebrafish embryos in a concentration-dependent manner, which were attenuated by supplementation with either CH223191 (CH), an aryl hydrocarbon receptor (AHR) inhibitor, or N-acetyl-l-cysteine (NAC), a reactive oxygen species (ROS) scavenger.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	165-173	aryl hydrocarbon receptor 1a	Danio rerio	210-213
34105899-9	2021	Moreover, after using CH223191, an inhibitor of the aromatic hydrocarbon receptor (AhR) pathway, dietary Trp could not exert neuroprotective roles in the rotenone-induced rat model of PD.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	22-30	aryl hydrocarbon receptor	Rattus norvegicus	83-86
33595948-8	2021	Interestingly, the effects of HCA on the growth and death of HepG2 cells were inhibited by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that the flavonoid effects are, at least partly, mediated by activation of AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	106-114	aryl hydrocarbon receptor	Homo sapiens	133-158
33595948-8	2021	Interestingly, the effects of HCA on the growth and death of HepG2 cells were inhibited by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that the flavonoid effects are, at least partly, mediated by activation of AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	106-114	aryl hydrocarbon receptor	Homo sapiens	160-163
33595948-8	2021	Interestingly, the effects of HCA on the growth and death of HepG2 cells were inhibited by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that the flavonoid effects are, at least partly, mediated by activation of AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	106-114	aryl hydrocarbon receptor	Homo sapiens	252-255
35500401-9	2022	Notably, the induction of Tregs was eliminated by co-treatment with an AhR antagonist, CH-223191, in each case.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	87-96	aryl-hydrocarbon receptor	Mus musculus	71-74
35412187-8	2022	Involvement of AhR signaling was evidenced by using in vivo an AhR antagonist, CH223191, and in vitro in AhR-knock-out HepaRG cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	79-87	aryl hydrocarbon receptor	Homo sapiens	15-18
35412187-8	2022	Involvement of AhR signaling was evidenced by using in vivo an AhR antagonist, CH223191, and in vitro in AhR-knock-out HepaRG cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	79-87	aryl hydrocarbon receptor	Homo sapiens	63-66
35182551-7	2022	Moreover, in the presence of the AhR antagonist, CH223191, or when the expression of AhR was knock-down using dsiRNAs, the cellular dormancy signaling pathway was blocked.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	49-57	aryl hydrocarbon receptor	Homo sapiens	33-36
35371054-7	2022	Conversely, AHR silencing or its blockade via CH-223191 improved the apoptosis of leukemic clones and mitigated MCL1 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	46-55	aryl hydrocarbon receptor	Homo sapiens	12-15
35182551-7	2022	Moreover, in the presence of the AhR antagonist, CH223191, or when the expression of AhR was knock-down using dsiRNAs, the cellular dormancy signaling pathway was blocked.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	49-57	aryl hydrocarbon receptor	Homo sapiens	85-88
35123993-6	2022	Pretreatment of an AhR antagonist (CH223191) can significantly increase the cell survival and mitigate HQ-induced toxicities such as DNA damage and apoptosis.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	35-43	aryl hydrocarbon receptor	Homo sapiens	19-22
35189914-6	2022	Moreover, the role of the aryl hydrocarbon receptor (AhR) pathway was assessed using an AhR-specific inhibitor (CH223191).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-120	aryl hydrocarbon receptor	Homo sapiens	26-51
35189914-6	2022	Moreover, the role of the aryl hydrocarbon receptor (AhR) pathway was assessed using an AhR-specific inhibitor (CH223191).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-120	aryl hydrocarbon receptor	Homo sapiens	53-56
35189914-6	2022	Moreover, the role of the aryl hydrocarbon receptor (AhR) pathway was assessed using an AhR-specific inhibitor (CH223191).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-120	aryl hydrocarbon receptor	Homo sapiens	88-91
34979820-9	2022	The reduction was also prevented by pretreatment with the AhR antagonist CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	73-82	aryl-hydrocarbon receptor	Mus musculus	58-61
35185907-16	2022	In addition, AhR antagonist CH223191 reversed the inhibition of FOR on Src expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-36	aryl-hydrocarbon receptor	Mus musculus	13-16
35185907-16	2022	In addition, AhR antagonist CH223191 reversed the inhibition of FOR on Src expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-36	Rous sarcoma oncogene	Mus musculus	71-74
35185907-17	2022	And the inhibition of FOR on NF-kappaB activation and inflammatory cytokine production were reversed by AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	119-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-38
35185907-17	2022	And the inhibition of FOR on NF-kappaB activation and inflammatory cytokine production were reversed by AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	119-127	aryl-hydrocarbon receptor	Mus musculus	104-107
35202128-3	2022	The present study examines AhR inhibition with the antagonist, CH223191, on IS-mediated impairment of vascular endothelial function and disruption of redox balance.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	63-71	aryl hydrocarbon receptor	Rattus norvegicus	27-30
35370278-4	2022	These effects were ameliorated by pretreatment with ascorbic acid, an antioxidant, and CH223191, an aryl hydrocarbon receptor (AhR) inhibitor, but not by apocynin, a reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	87-95	aryl hydrocarbon receptor	Rattus norvegicus	100-125
35370278-4	2022	These effects were ameliorated by pretreatment with ascorbic acid, an antioxidant, and CH223191, an aryl hydrocarbon receptor (AhR) inhibitor, but not by apocynin, a reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	87-95	aryl hydrocarbon receptor	Rattus norvegicus	127-130
35527008-4	2022	PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	233-242	interleukin 33	Homo sapiens	79-84
35527008-4	2022	PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	233-242	GLI family zinc finger 2	Homo sapiens	105-110
35527008-4	2022	PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	233-242	aryl hydrocarbon receptor	Homo sapiens	190-215
35527008-4	2022	PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	233-242	aryl hydrocarbon receptor	Homo sapiens	217-220
35527008-4	2022	PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	233-242	toll like receptor 4	Homo sapiens	250-270
35527008-4	2022	PM2.5 collected in Yokohama, Japan by the cyclone device significantly induced IL-33 expression in human THP-1 macrophages, and the induction was clearly suppressed by pretreatment with the aryl hydrocarbon receptor (AhR) antagonist CH-223191 or the Toll-like receptor 4 (TLR4) antagonist TAK-242.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	233-242	toll like receptor 4	Homo sapiens	272-276
33936043-7	2021	In contrast, the AhR antagonist CH223191 induced increased fungal loads, increased number of pulmonary CD11c+ leukocytes expressing activation markers, and a reduction in AhR and IDO production.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	32-40	aryl hydrocarbon receptor	Homo sapiens	17-20
33963491-10	2021	Acceleration of scratch wound closure was abolished by addition of the AhR-antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	86-94	aryl hydrocarbon receptor	Homo sapiens	71-74
33936043-7	2021	In contrast, the AhR antagonist CH223191 induced increased fungal loads, increased number of pulmonary CD11c+ leukocytes expressing activation markers, and a reduction in AhR and IDO production.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	32-40	integrin subunit alpha X	Homo sapiens	103-108
33936043-7	2021	In contrast, the AhR antagonist CH223191 induced increased fungal loads, increased number of pulmonary CD11c+ leukocytes expressing activation markers, and a reduction in AhR and IDO production.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	32-40	aryl hydrocarbon receptor	Homo sapiens	171-174
33936043-7	2021	In contrast, the AhR antagonist CH223191 induced increased fungal loads, increased number of pulmonary CD11c+ leukocytes expressing activation markers, and a reduction in AhR and IDO production.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	32-40	indoleamine 2,3-dioxygenase 1	Homo sapiens	179-182
33936043-12	2021	The AhR antagonist CH223191 induced a preferential expansion of myeloid DCs, reduced the number of Th1, Th22, and Treg cells, but increased Th17 differentiation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	aryl hydrocarbon receptor	Homo sapiens	4-7
34025677-4	2021	We determined that activation of the aryl hydrocarbon receptor (AHR) by kynurenine induced PD-1 expression, and this effect was significantly abrogated by the AHR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	174-182	aryl hydrocarbon receptor	Sus scrofa	37-62
34025677-4	2021	We determined that activation of the aryl hydrocarbon receptor (AHR) by kynurenine induced PD-1 expression, and this effect was significantly abrogated by the AHR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	174-182	aryl hydrocarbon receptor	Sus scrofa	64-67
34025677-4	2021	We determined that activation of the aryl hydrocarbon receptor (AHR) by kynurenine induced PD-1 expression, and this effect was significantly abrogated by the AHR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	174-182	aryl hydrocarbon receptor	Sus scrofa	159-162
33936062-6	2021	The BaP and Der f 1 co-exposure-induced TGFbeta1 expression and signaling activation were attenuated by either AhR antagonist CH223191 or AhR knockdown in HBECs.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	126-134	transforming growth factor, beta 1	Mus musculus	40-48
33936062-6	2021	The BaP and Der f 1 co-exposure-induced TGFbeta1 expression and signaling activation were attenuated by either AhR antagonist CH223191 or AhR knockdown in HBECs.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	126-134	aryl hydrocarbon receptor	Homo sapiens	111-114
33493289-8	2021	Administration of the AHR antagonist CH223191 to PCOS mice restored estrous cycling and decreased the number of atretic antral follicles, concomitant with downregulation of AHR and CYP1B1 in granulosa cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	37-45	aryl-hydrocarbon receptor	Mus musculus	173-176
33648937-13	2021	CH-223191, a specific AhR antagonist, inhibits CDDO-Im-induced IL-22 production in CD4+ T cells, which further confirmed the AhR-dependent regulation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	aryl-hydrocarbon receptor	Mus musculus	22-25
33648937-13	2021	CH-223191, a specific AhR antagonist, inhibits CDDO-Im-induced IL-22 production in CD4+ T cells, which further confirmed the AhR-dependent regulation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	interleukin 22	Mus musculus	63-68
33648937-13	2021	CH-223191, a specific AhR antagonist, inhibits CDDO-Im-induced IL-22 production in CD4+ T cells, which further confirmed the AhR-dependent regulation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	CD4 antigen	Mus musculus	83-86
33648937-13	2021	CH-223191, a specific AhR antagonist, inhibits CDDO-Im-induced IL-22 production in CD4+ T cells, which further confirmed the AhR-dependent regulation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	aryl-hydrocarbon receptor	Mus musculus	125-128
33607146-7	2021	Autoradiographic quantification of serotonin transporters showed that both the TDO inhibitor 680C91 and the AhR antagonist CH-223191 potentiated the neurotoxicity induced by MDMA, while administration of exogenous L-kynurenine or of the AhR positive modulator 3,3"-diindolylmethane (DIM) partially prevented the serotonergic damage induced by the drug.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	123-132	aryl hydrocarbon receptor	Rattus norvegicus	108-111
33607146-7	2021	Autoradiographic quantification of serotonin transporters showed that both the TDO inhibitor 680C91 and the AhR antagonist CH-223191 potentiated the neurotoxicity induced by MDMA, while administration of exogenous L-kynurenine or of the AhR positive modulator 3,3"-diindolylmethane (DIM) partially prevented the serotonergic damage induced by the drug.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	123-132	aryl hydrocarbon receptor	Rattus norvegicus	237-240
33493289-8	2021	Administration of the AHR antagonist CH223191 to PCOS mice restored estrous cycling and decreased the number of atretic antral follicles, concomitant with downregulation of AHR and CYP1B1 in granulosa cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	37-45	aryl-hydrocarbon receptor	Mus musculus	22-25
33493289-8	2021	Administration of the AHR antagonist CH223191 to PCOS mice restored estrous cycling and decreased the number of atretic antral follicles, concomitant with downregulation of AHR and CYP1B1 in granulosa cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	37-45	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	181-187
33670600-11	2021	Use of CH-223191, an inhibitor of the AhR, suppressed the anti-angiogenic activity of I3AA but failed to mitigate the effects of IAld.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	7-16	aryl hydrocarbon receptor	Mesocricetus auratus	38-41
33406025-7	2021	Similarly, pharmacological AHR antagonism using resveratrol and CH223191 were also found to rescue angiogenesis in cell and aortic ring cultures.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	64-72	aryl hydrocarbon receptor	Homo sapiens	27-30
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	44-53	aryl hydrocarbon receptor	Homo sapiens	27-30
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	44-53	peroxisome proliferator activated receptor alpha	Homo sapiens	90-95
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	44-53	solute carrier family 27 member 1	Homo sapiens	126-131
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	44-53	peroxisome proliferator activated receptor alpha	Homo sapiens	242-247
33288249-10	2021	Furthermore, inhibition of AHR signaling by CH-223191 abolished BaP-induced repression of PPARA/G signaling and activation of FATP1 in BEAS-2B cells, demonstrating the regulatory role of AHR signaling in fatty acid accumulation via mediating PPARA/G-FATP1 signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	44-53	solute carrier family 27 member 1	Homo sapiens	250-255
33001270-8	2021	The effects of HCA on the growth and death of PC-3 cells were blocked by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that HCA effects are partly involved in AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	88-96	aryl hydrocarbon receptor	Homo sapiens	115-140
33001270-8	2021	The effects of HCA on the growth and death of PC-3 cells were blocked by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that HCA effects are partly involved in AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	88-96	aryl hydrocarbon receptor	Homo sapiens	142-145
33001270-8	2021	The effects of HCA on the growth and death of PC-3 cells were blocked by culturing with CH223191, an antagonist of aryl hydrocarbon receptor (AHR), suggesting that HCA effects are partly involved in AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	88-96	aryl hydrocarbon receptor	Homo sapiens	199-202
31922435-9	2020	Use of an AhR antagonist (CH223191) resulted in significant inhibition of the AhR signaling and increases in M2 marker expression, but led to elevation of expression of M1 markers in the CRE-induced asthma model.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	26-34	aryl-hydrocarbon receptor	Mus musculus	10-13
33381211-9	2020	Furthermore, AhR antagonist CH223191 inhibited the activation of AKT/GSK-3beta/beta-catenin signaling, whereas the expression of CYP1A1 (marker of AhR activation) was not affected by the AKT inhibitor in AS-IV-exposed NHEMs.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-36	aryl hydrocarbon receptor	Homo sapiens	13-16
33381211-9	2020	Furthermore, AhR antagonist CH223191 inhibited the activation of AKT/GSK-3beta/beta-catenin signaling, whereas the expression of CYP1A1 (marker of AhR activation) was not affected by the AKT inhibitor in AS-IV-exposed NHEMs.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-36	AKT serine/threonine kinase 1	Homo sapiens	65-68
33381211-9	2020	Furthermore, AhR antagonist CH223191 inhibited the activation of AKT/GSK-3beta/beta-catenin signaling, whereas the expression of CYP1A1 (marker of AhR activation) was not affected by the AKT inhibitor in AS-IV-exposed NHEMs.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-36	glycogen synthase kinase 3 alpha	Homo sapiens	69-78
33381211-9	2020	Furthermore, AhR antagonist CH223191 inhibited the activation of AKT/GSK-3beta/beta-catenin signaling, whereas the expression of CYP1A1 (marker of AhR activation) was not affected by the AKT inhibitor in AS-IV-exposed NHEMs.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-36	catenin beta 1	Homo sapiens	79-91
33322705-8	2020	In contrast, AhR antagonist CH-223191 significantly blocked BNF-induced cell cycle arrest.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	28-37	aryl-hydrocarbon receptor	Mus musculus	13-16
33022287-6	2020	Using 4-Methypyrazole to inhibit ethanol metabolism, and CH-223191 to antagonize the AhR receptor, we found that an AhR-dependent increase in alcohol dehydrogenase (ADH) activity was essential for cell death upon MEHP/ethanol co-exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-66	aryl hydrocarbon receptor	Homo sapiens	85-88
33022287-6	2020	Using 4-Methypyrazole to inhibit ethanol metabolism, and CH-223191 to antagonize the AhR receptor, we found that an AhR-dependent increase in alcohol dehydrogenase (ADH) activity was essential for cell death upon MEHP/ethanol co-exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-66	aldo-keto reductase family 1 member A1	Homo sapiens	142-163
33022287-6	2020	Using 4-Methypyrazole to inhibit ethanol metabolism, and CH-223191 to antagonize the AhR receptor, we found that an AhR-dependent increase in alcohol dehydrogenase (ADH) activity was essential for cell death upon MEHP/ethanol co-exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-66	aldo-keto reductase family 1 member A1	Homo sapiens	165-168
32985761-5	2020	TCDD"s effects were abolished by culturing with CH223191, an inhibitor of AHR signalling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	48-56	aryl hydrocarbon receptor	Homo sapiens	74-77
32985761-9	2020	These effects were reversed by treatment with CH223191, an inhibitor of AHR.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	46-54	aryl hydrocarbon receptor	Homo sapiens	72-75
31922435-9	2020	Use of an AhR antagonist (CH223191) resulted in significant inhibition of the AhR signaling and increases in M2 marker expression, but led to elevation of expression of M1 markers in the CRE-induced asthma model.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	26-34	aryl-hydrocarbon receptor	Mus musculus	78-81
32781018-8	2020	The induction of tryptophan and kynurenine on insulin growth factor binding protein 1 is abrogated by CH223191, an aryl hydrocarbon receptor inhibitor.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	102-110	aryl hydrocarbon receptor	Homo sapiens	115-140
33050543-7	2020	Pharmacological inhibition of the pregnane-X receptor using CH223191 and the aryl-hydrocarbon receptor using ketoconazole diminished the IS-elicited effects, suggesting that these receptors were the major receptors of IS in these models.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	60-68	nuclear receptor subfamily 1 group I member 2	Homo sapiens	34-53
32900487-5	2020	In contrast, AHR antagonist, CH223191 or resveratrol, counteracted the AHR-mediated MALAT1 induction and MALAT1-enahnced EZH2 activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	aryl hydrocarbon receptor	Homo sapiens	13-16
32900487-5	2020	In contrast, AHR antagonist, CH223191 or resveratrol, counteracted the AHR-mediated MALAT1 induction and MALAT1-enahnced EZH2 activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	aryl hydrocarbon receptor	Homo sapiens	71-74
32900487-5	2020	In contrast, AHR antagonist, CH223191 or resveratrol, counteracted the AHR-mediated MALAT1 induction and MALAT1-enahnced EZH2 activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	84-90
32900487-5	2020	In contrast, AHR antagonist, CH223191 or resveratrol, counteracted the AHR-mediated MALAT1 induction and MALAT1-enahnced EZH2 activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	105-111
32900487-5	2020	In contrast, AHR antagonist, CH223191 or resveratrol, counteracted the AHR-mediated MALAT1 induction and MALAT1-enahnced EZH2 activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	121-125
32721735-4	2020	Selective antagonists of the receptors, including alpha-naphthoflavone, CH223191, and CINPA 1, inhibited p,p"-DDE- and o,p"-DDE-induced LDH release and caspase-3 activity, while specific siRNAs (Ahr and Car siRNA) reduced the levels of p,p"-DDE- and o,p"-DDE-induced autophagosome formation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	72-80	caspase 3	Mus musculus	152-161
32721735-4	2020	Selective antagonists of the receptors, including alpha-naphthoflavone, CH223191, and CINPA 1, inhibited p,p"-DDE- and o,p"-DDE-induced LDH release and caspase-3 activity, while specific siRNAs (Ahr and Car siRNA) reduced the levels of p,p"-DDE- and o,p"-DDE-induced autophagosome formation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	72-80	aryl hydrocarbon receptor	Homo sapiens	195-198
32721735-4	2020	Selective antagonists of the receptors, including alpha-naphthoflavone, CH223191, and CINPA 1, inhibited p,p"-DDE- and o,p"-DDE-induced LDH release and caspase-3 activity, while specific siRNAs (Ahr and Car siRNA) reduced the levels of p,p"-DDE- and o,p"-DDE-induced autophagosome formation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	72-80	nuclear receptor subfamily 1, group I, member 3	Mus musculus	203-206
32799115-7	2020	Conversely the AhR antagonist CH223191 could inhibit this effect.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	30-38	aryl-hydrocarbon receptor	Mus musculus	15-18
32416216-6	2020	Daily administration (14 days) of AHR antagonist, CH-223191 (5 mg.kg-1.day-1, gavage), simultaneously to CIH prevented the increase in systolic blood pressure (SBP) by 53 +- 12% and in diastolic blood pressure (DBP) by 44 +- 16%.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	50-59	aryl hydrocarbon receptor	Rattus norvegicus	34-37
32041038-10	2020	In addition, with the presence of AhR antagonist, CH223191, the effects of TCDD on the gene expression and the spontaneous cell movement were effectively reversed.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	50-58	aryl hydrocarbon receptor	Homo sapiens	34-37
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	NK2 homeobox 5	Danio rerio	130-136
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	SRY-box transcription factor 9b	Danio rerio	138-143
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	nfe2 like bZIP transcription factor 2b	Danio rerio	171-176
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	glutathione S-transferase pi 1.2	Danio rerio	178-183
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	glutathione S-transferase pi 1.1	Danio rerio	185-190
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	superoxide dismutase 2, mitochondrial	Danio rerio	192-196
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	tumor protein p53	Danio rerio	223-226
31837856-8	2020	Incidentally, both CH and NAC attenuated the EOM-induced changes in the mRNA expression of genes involved in cardiac development (nkx2.5, sox9b), oxidative stress (nrf2a, nrf2b, gstp1, gstp2, sod2, ho1, cat) and apoptosis (p53, bax).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-21	BCL2 associated X, apoptosis regulator a	Danio rerio	228-231
32647342-9	2020	Furthermore, treatment of infected WT mice with an AhR-specific antagonist (CH223191) reproduced the main findings obtained in AhR-/- mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	76-84	aryl-hydrocarbon receptor	Mus musculus	51-54
32647342-9	2020	Furthermore, treatment of infected WT mice with an AhR-specific antagonist (CH223191) reproduced the main findings obtained in AhR-/- mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	76-84	aryl-hydrocarbon receptor	Mus musculus	127-130
32395570-13	2020	Indeed, AhR inhibitors (CH-223191 and 3",4"-dimethoxyflavone [DMF]) partially rescued secreted CXCL12 protein levels in BMSCs treated with KYN.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	24-33	aryl-hydrocarbon receptor	Mus musculus	8-11
32395570-13	2020	Indeed, AhR inhibitors (CH-223191 and 3",4"-dimethoxyflavone [DMF]) partially rescued secreted CXCL12 protein levels in BMSCs treated with KYN.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	24-33	chemokine (C-X-C motif) ligand 12	Mus musculus	95-101
31699484-4	2020	In this study, we found that the reactive oxygen species (ROS) scavenger, N-Acetyl-L-cysteine (NAC), and AHR inhibitors, CH223191 (CH) and StemRegenin 1, significantly counteracted the TCE-induced heart malformations in zebrafish embryos.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	121-129	aryl hydrocarbon receptor 1a	Danio rerio	105-108
31699484-4	2020	In this study, we found that the reactive oxygen species (ROS) scavenger, N-Acetyl-L-cysteine (NAC), and AHR inhibitors, CH223191 (CH) and StemRegenin 1, significantly counteracted the TCE-induced heart malformations in zebrafish embryos.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	121-123	aryl hydrocarbon receptor 1a	Danio rerio	105-108
31699484-6	2020	TCE did not affect ahr2 and cyp1a expression, but increased cyp1b1 expression, which was restored by CH supplementation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	101-103	cytochrome P450, family 1, subfamily B, polypeptide 1	Danio rerio	60-66
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	nfe2 like bZIP transcription factor 2a	Danio rerio	62-66
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	nfe2 like bZIP transcription factor 2b	Danio rerio	85-90
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	glutathione S-transferase pi 1.1	Danio rerio	92-97
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	superoxide dismutase 2, mitochondrial	Danio rerio	99-103
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	NAD(P)H dehydrogenase, quinone 1	Danio rerio	110-114
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	GATA binding protein 4	Danio rerio	151-156
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	heart and neural crest derivatives expressed 2	Danio rerio	158-163
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	v-fos FBJ murine osteosarcoma viral oncogene homolog Ab	Danio rerio	165-170
31699484-7	2020	CH also attenuated the TCE-induced mRNA expression changes of Nrf2 signalling genes (nrf2b, gstp2, sod2, ho1, nqo1) and cardiac differentiation genes (gata4, hand2, c-fos, sox9b).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-2	SRY-box transcription factor 9b	Danio rerio	172-177
31721030-8	2020	The chemical AhR antagonist, CH223191, was effective at preventing the effects of PCB126 but not IS, indicating AhR ligand specificity of CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	aryl hydrocarbon receptor	Homo sapiens	13-16
31699484-8	2020	In addition, the TCE enhanced SOD activity was attenuated by CH.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	61-63	superoxide dismutase 2, mitochondrial	Danio rerio	30-33
31820026-12	2020	In addition, PCB 126 suppressed osteoblastogenesis in primary bone marrow mesenchymal stem cell cultures which was blunted by the AhR antagonist CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	145-154	aryl hydrocarbon receptor	Rattus norvegicus	130-133
31812582-11	2020	To validate that these effects are in fact due to AhR signaling pathway, we utilized two known AhR antagonists: CH-223191, and 3",4"-dimethoxyflavone to try to block AhR signaling and rescue kynurenine /AhR mediated effects.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-121	aryl-hydrocarbon receptor	Mus musculus	50-53
31812582-11	2020	To validate that these effects are in fact due to AhR signaling pathway, we utilized two known AhR antagonists: CH-223191, and 3",4"-dimethoxyflavone to try to block AhR signaling and rescue kynurenine /AhR mediated effects.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-121	aryl-hydrocarbon receptor	Mus musculus	95-98
31812582-11	2020	To validate that these effects are in fact due to AhR signaling pathway, we utilized two known AhR antagonists: CH-223191, and 3",4"-dimethoxyflavone to try to block AhR signaling and rescue kynurenine /AhR mediated effects.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-121	aryl-hydrocarbon receptor	Mus musculus	95-98
31812582-11	2020	To validate that these effects are in fact due to AhR signaling pathway, we utilized two known AhR antagonists: CH-223191, and 3",4"-dimethoxyflavone to try to block AhR signaling and rescue kynurenine /AhR mediated effects.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-121	aryl-hydrocarbon receptor	Mus musculus	95-98
31721030-8	2020	The chemical AhR antagonist, CH223191, was effective at preventing the effects of PCB126 but not IS, indicating AhR ligand specificity of CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	29-37	aryl hydrocarbon receptor	Homo sapiens	112-115
31721030-8	2020	The chemical AhR antagonist, CH223191, was effective at preventing the effects of PCB126 but not IS, indicating AhR ligand specificity of CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	138-146	aryl hydrocarbon receptor	Homo sapiens	13-16
31721030-8	2020	The chemical AhR antagonist, CH223191, was effective at preventing the effects of PCB126 but not IS, indicating AhR ligand specificity of CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	138-146	aryl hydrocarbon receptor	Homo sapiens	112-115
32841893-8	2020	We observed significant effects on proliferation, DNA strand breaks and mutagenic activity after BaP exposure in PC-3 cells, and inhibitors of CYP1 and the AhR transcription factor alpha -naphthoflavone (ANF) and CH223191 treatment clearly reduced both cell survival and mutagenesis associated with BaP exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	213-221	aryl hydrocarbon receptor	Homo sapiens	156-159
31775093-12	2020	CH223191, an AhR antagonist, reversed the upregulation of NFL and phosphorylation of ERK1/2 and p38 induced by TCDD.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-8	aryl hydrocarbon receptor	Rattus norvegicus	13-16
31775093-12	2020	CH223191, an AhR antagonist, reversed the upregulation of NFL and phosphorylation of ERK1/2 and p38 induced by TCDD.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-8	neurofilament light chain	Rattus norvegicus	58-61
31775093-12	2020	CH223191, an AhR antagonist, reversed the upregulation of NFL and phosphorylation of ERK1/2 and p38 induced by TCDD.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-8	mitogen activated protein kinase 3	Rattus norvegicus	85-91
31775093-12	2020	CH223191, an AhR antagonist, reversed the upregulation of NFL and phosphorylation of ERK1/2 and p38 induced by TCDD.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-8	mitogen activated protein kinase 14	Rattus norvegicus	96-99
32841893-8	2020	We observed significant effects on proliferation, DNA strand breaks and mutagenic activity after BaP exposure in PC-3 cells, and inhibitors of CYP1 and the AhR transcription factor alpha -naphthoflavone (ANF) and CH223191 treatment clearly reduced both cell survival and mutagenesis associated with BaP exposure.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	213-221	prohibitin 2	Homo sapiens	299-302
31885805-11	2019	CH223191, an inhibitor of AHR, significantly inhibits IS-induced endothelial hyperpermeability.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-8	aryl hydrocarbon receptor	Bos taurus	26-29
31915651-3	2019	Methods: Morphological changes, viability, and rescue effects of an AHR antagonist (CH223191) were examined in BM-MSCs after exposure to FR.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	84-92	aryl hydrocarbon receptor	Homo sapiens	68-71
31671369-8	2019	It is intriguing that CH223191 successfully abolished the holistic effects of dioxin on gut microbiota, which inferred that growth of gut microbes was directly controlled by AhR activation without the involvement of host feedback modulation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	22-30	aryl hydrocarbon receptor 1a	Danio rerio	174-177
31647221-8	2019	Involvement of the AhR in the action of 3-bromotryptanthrin was confirmed by the ability of the AhR antagonists CH223191 and SR1 to inhibit 3-bromotryptanthrin-dependent reporter gene induction in human HG2L7.5c1 cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-120	aryl hydrocarbon receptor	Homo sapiens	19-22
31647221-8	2019	Involvement of the AhR in the action of 3-bromotryptanthrin was confirmed by the ability of the AhR antagonists CH223191 and SR1 to inhibit 3-bromotryptanthrin-dependent reporter gene induction in human HG2L7.5c1 cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	112-120	aryl hydrocarbon receptor	Homo sapiens	96-99
30720065-7	2019	These effects of TCDD were abolished by pretreatment with CH223191, an inhibitor of AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	58-66	aryl hydrocarbon receptor	Homo sapiens	84-87
31676321-8	2019	The relationship between alpinetin-regulated AhR/suv39h1/TSC2/mTORC1 signals, autophagy and apoptosis of Caco-2 and NCM460 cells was confirmed by using CH223191, siAhR, siTSC2 and chloroquine.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	152-160	aryl hydrocarbon receptor	Homo sapiens	45-48
31676321-8	2019	The relationship between alpinetin-regulated AhR/suv39h1/TSC2/mTORC1 signals, autophagy and apoptosis of Caco-2 and NCM460 cells was confirmed by using CH223191, siAhR, siTSC2 and chloroquine.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	152-160	CREB regulated transcription coactivator 1	Mus musculus	62-68
30982974-12	2019	Finally, AhR antagonist CH223191 and NAC inhibited BaP co-exposure with Der f 1-induced lung inflammation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	24-32	aryl-hydrocarbon receptor	Mus musculus	9-12
31416966-10	2019	Blocking the interaction between AHR and kynurenine with CH223191 reduced the proliferation of colon cancer cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-65	aryl hydrocarbon receptor	Homo sapiens	33-36
31216508-10	2019	The differential antagonizing effects of CH223191 on PHCZ-induced AhR activity supported such pose differentiation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	41-49	aryl hydrocarbon receptor	Homo sapiens	66-69
31694515-3	2019	The activation of AhR was confirmed using selective AhR inhibitor CH-223191 and by evaluating expression of the target CYP1A1 gene.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	66-75	aryl hydrocarbon receptor	Rattus norvegicus	18-21
31093659-6	2019	AhR antagonist CH223191 suppressed the increase in IL-33 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	15-23	aryl-hydrocarbon receptor	Mus musculus	0-3
31093659-6	2019	AhR antagonist CH223191 suppressed the increase in IL-33 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	15-23	interleukin 33	Mus musculus	51-56
30739789-6	2019	In addition to increased AhR transcriptional activity induced by skatole, the AhR antagonist CH223191 partially suppressed of skatole-induced IEC death.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	93-101	aryl hydrocarbon receptor	Homo sapiens	78-81
30508555-8	2019	Inhibition of AhR by an AhR antagonist, CH223191, and siRNA transfection of AhR and AhR nuclear translocator reduced alphaNF-induced AhR-responsive luciferase activity, CHOP expression, and cell death.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	40-48	aryl-hydrocarbon receptor	Mus musculus	14-17
30056444-4	2019	PGN-induced secretion of inflammatory factors TNF-alpha and IL-8 in human SZ95 sebocytes was suppressed after knockdown of AhR and pretreatment with the AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	168-176	tumor necrosis factor	Homo sapiens	46-55
30528028-7	2019	So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	102-110	aryl hydrocarbon receptor	Rattus norvegicus	15-18
30528028-7	2019	So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	102-110	aryl hydrocarbon receptor	Rattus norvegicus	86-89
30987575-0	2019	The Opposite Effect of L-kynurenine and Ahr Inhibitor Ch223191 on Apoptotic Protein Expression in Pancreatic Carcinoma Cells (Panc-1).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	54-62	aryl hydrocarbon receptor	Homo sapiens	40-43
30987575-4	2019	METHODS: The investigated substances were added alone or in combination with the AhR inhibitor (CH223191) to cultures of PANC-1 cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	96-104	aryl hydrocarbon receptor	Homo sapiens	81-84
30793600-2	2019	AHR antagonist, 2-methyl-2 H-pyrazole-3-carboxylic acid (2-methyl-4- o-tolylazo-phenyl)-amide, CH223191, has been reported to inhibit the AHR transcription activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-93	aryl hydrocarbon receptor	Homo sapiens	0-3
30793600-2	2019	AHR antagonist, 2-methyl-2 H-pyrazole-3-carboxylic acid (2-methyl-4- o-tolylazo-phenyl)-amide, CH223191, has been reported to inhibit the AHR transcription activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-93	aryl hydrocarbon receptor	Homo sapiens	138-141
30793600-2	2019	AHR antagonist, 2-methyl-2 H-pyrazole-3-carboxylic acid (2-methyl-4- o-tolylazo-phenyl)-amide, CH223191, has been reported to inhibit the AHR transcription activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	95-103	aryl hydrocarbon receptor	Homo sapiens	0-3
30793600-2	2019	AHR antagonist, 2-methyl-2 H-pyrazole-3-carboxylic acid (2-methyl-4- o-tolylazo-phenyl)-amide, CH223191, has been reported to inhibit the AHR transcription activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	95-103	aryl hydrocarbon receptor	Homo sapiens	138-141
30793600-3	2019	However, CH223191 antagonist activity toward an AHR endogenous ligand, 6-formylindolo[3,2- b]carbazole (FICZ), and its mode of action remain to be elusive.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	9-17	aryl hydrocarbon receptor	Homo sapiens	48-51
30793600-6	2019	Indeed, we observed that CH223191 is able to inhibit the catalytic activity of CYP1A1, with an IC50 value of 1.48 muM.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	25-33	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	79-85
30793600-7	2019	Our experiments with silencing RNA sequences showed that ROS formation by mitochondria might take part as a primary event in the downregulation of CYP1A1 by CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	157-165	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	147-153
30793600-8	2019	We describe a new mechanism for inhibition of AHR-induced CYP1A1 by CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	68-76	aryl hydrocarbon receptor	Homo sapiens	46-49
30793600-8	2019	We describe a new mechanism for inhibition of AHR-induced CYP1A1 by CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	68-76	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	58-64
30793600-9	2019	The sensitivity of the AHR to oxidants and its possible reversibility by antioxidants supports the view that CH223191-induced mitochondrial dysfunction might be involved in this pharmacological event.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	109-117	aryl hydrocarbon receptor	Homo sapiens	23-26
30056444-4	2019	PGN-induced secretion of inflammatory factors TNF-alpha and IL-8 in human SZ95 sebocytes was suppressed after knockdown of AhR and pretreatment with the AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	168-176	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
30056444-4	2019	PGN-induced secretion of inflammatory factors TNF-alpha and IL-8 in human SZ95 sebocytes was suppressed after knockdown of AhR and pretreatment with the AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	168-176	aryl hydrocarbon receptor	Homo sapiens	123-126
30056444-4	2019	PGN-induced secretion of inflammatory factors TNF-alpha and IL-8 in human SZ95 sebocytes was suppressed after knockdown of AhR and pretreatment with the AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	168-176	aryl hydrocarbon receptor	Homo sapiens	153-156
30056444-6	2019	Furthermore, PGN-induced expression of myeloid differentiation factor 88 (MyD88), phospho-p38MAPK (p-p38MAPK), and p-p65NF-kappaB was strengthened by TCDD and repressed by CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	172-180	MYD88 innate immune signal transduction adaptor	Homo sapiens	39-72
30205954-7	2018	Blockade of AHR by a pharmacological antagonist CH-223191 abolished the IG-induced inhibition of HIF activation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	48-57	aryl hydrocarbon receptor	Homo sapiens	12-15
30165701-9	2018	Resveratrol, a chemo preventive agent and AhR antagonist, and CH-223191, a potent and specific AhR inhibitor, confer protection against BaP-induced mitochondrial dysfunction and pancreatic pathology.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	62-71	aryl-hydrocarbon receptor	Mus musculus	95-98
30066859-5	2018	The effects of TCDD on the HepG2 cells were abolished by culture with CH223191, an inhibitor of AHR signaling.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	70-78	aryl hydrocarbon receptor	Homo sapiens	96-99
29522993-9	2018	Using AhR antagonist CH223191 and/or siRNA assays, we demonstrated that certain AhR agonists upregulated SLC6A19 expression via AhR, including TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (1,2,3,7,8-PeCDD), 2,3,4,7,8- pentachlorodibenzofuran (2,3,4,7,8-PeCDF) and PCB126.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	aryl hydrocarbon receptor	Homo sapiens	80-83
30127998-8	2018	The AhR antagonist CH-223191, blocks the effects on TCDD-induced RANKL, COX-2, PGE2 and CXCR4 changes.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
30127998-8	2018	The AhR antagonist CH-223191, blocks the effects on TCDD-induced RANKL, COX-2, PGE2 and CXCR4 changes.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	C-X-C motif chemokine receptor 4	Homo sapiens	88-93
30071202-7	2018	The AhR antagonist CH223191 obviously abolished NLRP3 inflammasome activation inhibited by cardamonin.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	aryl-hydrocarbon receptor	Mus musculus	4-7
30071202-7	2018	The AhR antagonist CH223191 obviously abolished NLRP3 inflammasome activation inhibited by cardamonin.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	NLR family, pyrin domain containing 3	Mus musculus	48-53
30127998-8	2018	The AhR antagonist CH-223191, blocks the effects on TCDD-induced RANKL, COX-2, PGE2 and CXCR4 changes.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	aryl hydrocarbon receptor	Homo sapiens	4-7
30127998-8	2018	The AhR antagonist CH-223191, blocks the effects on TCDD-induced RANKL, COX-2, PGE2 and CXCR4 changes.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	TNF superfamily member 11	Homo sapiens	65-70
30166541-9	2018	Finally, CH223191 abolished the amelioration of alpinetin on colitis, induction of Treg cells and regulation of miR-302/DNMT-1/CREB signals in colons of colitis mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	9-17	microRNA 302a	Mus musculus	112-119
30166541-9	2018	Finally, CH223191 abolished the amelioration of alpinetin on colitis, induction of Treg cells and regulation of miR-302/DNMT-1/CREB signals in colons of colitis mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	9-17	DNA methyltransferase (cytosine-5) 1	Mus musculus	120-126
30166541-9	2018	Finally, CH223191 abolished the amelioration of alpinetin on colitis, induction of Treg cells and regulation of miR-302/DNMT-1/CREB signals in colons of colitis mice.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	9-17	cAMP responsive element binding protein 1	Mus musculus	127-131
29522993-9	2018	Using AhR antagonist CH223191 and/or siRNA assays, we demonstrated that certain AhR agonists upregulated SLC6A19 expression via AhR, including TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (1,2,3,7,8-PeCDD), 2,3,4,7,8- pentachlorodibenzofuran (2,3,4,7,8-PeCDF) and PCB126.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	solute carrier family 6 member 19	Homo sapiens	105-112
29522993-9	2018	Using AhR antagonist CH223191 and/or siRNA assays, we demonstrated that certain AhR agonists upregulated SLC6A19 expression via AhR, including TCDD, 1,2,3,7,8-pentachlorodibenzo-p-dioxin (1,2,3,7,8-PeCDD), 2,3,4,7,8- pentachlorodibenzofuran (2,3,4,7,8-PeCDF) and PCB126.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	aryl hydrocarbon receptor	Homo sapiens	80-83
29351992-8	2018	The inhibition of AHR by siRNA or antagonists, CH-223191 and trimethoxyflavone, induces apoptosis in human MPNST cells.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	47-56	aryl hydrocarbon receptor	Homo sapiens	18-21
29449535-5	2018	It activated AhR in CD4+ T cells under hypoxic microenvironment; CH223191 (a specific AhR antagonist) and siAhR-3 abolished NOR-promoted Treg differentiation.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	65-73	aryl-hydrocarbon receptor	Mus musculus	86-89
28956952-6	2018	The AhR antagonist CH223191 (8 mg/kg/day) reversed the development of PAH in this model in vivo and normalized lung CYP1A1 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	aryl hydrocarbon receptor	Homo sapiens	4-7
28956952-6	2018	The AhR antagonist CH223191 (8 mg/kg/day) reversed the development of PAH in this model in vivo and normalized lung CYP1A1 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	116-122
27129092-11	2016	AhR agonists (BP and ITE) decreased E-cadherin expression, while AhR antagonist (CH223191) increased it in human primary keratinocytes.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	81-89	aryl hydrocarbon receptor	Homo sapiens	65-68
28655636-3	2017	Using the antagonist CH223191, DE induced CYP1A1 and attenuation of CXCL10 among other genes were observed to be aryl hydrocarbon receptor dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	42-48
28655636-3	2017	Using the antagonist CH223191, DE induced CYP1A1 and attenuation of CXCL10 among other genes were observed to be aryl hydrocarbon receptor dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	C-X-C motif chemokine ligand 10	Homo sapiens	68-74
28860601-9	2017	Furthermore, CH223191, an antagonist of the aryl hydrocarbon receptor (AhR), counteracted TCDD-induced hsa-miR-608 and CDC42 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	13-21	aryl hydrocarbon receptor	Homo sapiens	44-69
28860601-9	2017	Furthermore, CH223191, an antagonist of the aryl hydrocarbon receptor (AhR), counteracted TCDD-induced hsa-miR-608 and CDC42 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	13-21	aryl hydrocarbon receptor	Homo sapiens	71-74
28860601-9	2017	Furthermore, CH223191, an antagonist of the aryl hydrocarbon receptor (AhR), counteracted TCDD-induced hsa-miR-608 and CDC42 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	13-21	microRNA 608	Homo sapiens	103-114
28860601-9	2017	Furthermore, CH223191, an antagonist of the aryl hydrocarbon receptor (AhR), counteracted TCDD-induced hsa-miR-608 and CDC42 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	13-21	cell division cycle 42	Homo sapiens	119-124
27055685-7	2017	The AhR antagonist CH-223191 or AhR siRNA reduced the inhibitory effect of 25 nM TCDD on ADH1A, 4 and 6 expression 50-100 % (p &lt; 0.05).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	aryl hydrocarbon receptor	Homo sapiens	4-7
27055685-7	2017	The AhR antagonist CH-223191 or AhR siRNA reduced the inhibitory effect of 25 nM TCDD on ADH1A, 4 and 6 expression 50-100 % (p &lt; 0.05).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	89-94
27697457-4	2016	Boyden chamber-based cell migration assay showed that activated AhR in HFL-1cells significantly enhanced cell migration in response to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), and a known AhR antagonist, CH223191, inhibited its migratory activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	210-218	aryl hydrocarbon receptor	Homo sapiens	64-67
27269377-11	2016	6-PN mediated induction of EROD activity was also inhibited by the AhR antagonist CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	82-90	aryl hydrocarbon receptor	Homo sapiens	67-70
28332288-6	2017	Meanwhile, the effect of tetrandrine on the either STAT3 or STAT5 phosphorylation was almost completely reversed by the AhR antagonist CH223191 and the AhR knockdown.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	135-143	signal transducer and activator of transcription 3	Mus musculus	51-56
28332288-6	2017	Meanwhile, the effect of tetrandrine on the either STAT3 or STAT5 phosphorylation was almost completely reversed by the AhR antagonist CH223191 and the AhR knockdown.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	135-143	signal transducer and activator of transcription 5A	Mus musculus	60-65
28332288-6	2017	Meanwhile, the effect of tetrandrine on the either STAT3 or STAT5 phosphorylation was almost completely reversed by the AhR antagonist CH223191 and the AhR knockdown.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	135-143	aryl-hydrocarbon receptor	Mus musculus	120-123
27020609-7	2016	Studies are presented showing that the AHR antagonists alpha-naphthoflavone and CH-223191 significantly reduce obesity and adiposity and ameliorates liver steatosis in male C57Bl/6J mice fed a Western diet.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	80-89	aryl-hydrocarbon receptor	Mus musculus	39-42
26861731-9	2016	The downregulation of cyclinD1 and upregulation of p27 were abolished by co-treatment with CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	91-99	cyclin D1	Homo sapiens	22-30
26861731-9	2016	The downregulation of cyclinD1 and upregulation of p27 were abolished by co-treatment with CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	91-99	interferon alpha inducible protein 27	Homo sapiens	51-54
25797602-6	2015	Using the AhR competitive inhibitors alpha naphthoflavone and CH-223191, we show that phosphorylation of p38MAPK is AhR dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	62-71	aryl hydrocarbon receptor	Homo sapiens	10-13
26877836-5	2015	CH-223191, an AhR antagonist, blocked the endosulfan-induced increase in CYP1A1 mRNA and protein expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	aryl hydrocarbon receptor	Homo sapiens	14-17
26877836-5	2015	CH-223191, an AhR antagonist, blocked the endosulfan-induced increase in CYP1A1 mRNA and protein expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-79
27551479-6	2015	Pharmacological inhibition using the AHR-antagonist (CH223191) modulates the CSC-altered expression of apoptotic proteins and significantly abrogates DNA fragmentation though the cleavage of PARP appears AHR independent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	53-61	aryl-hydrocarbon receptor	Mus musculus	37-40
27551479-6	2015	Pharmacological inhibition using the AHR-antagonist (CH223191) modulates the CSC-altered expression of apoptotic proteins and significantly abrogates DNA fragmentation though the cleavage of PARP appears AHR independent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	53-61	poly (ADP-ribose) polymerase family, member 1	Mus musculus	191-195
27551479-6	2015	Pharmacological inhibition using the AHR-antagonist (CH223191) modulates the CSC-altered expression of apoptotic proteins and significantly abrogates DNA fragmentation though the cleavage of PARP appears AHR independent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	53-61	aryl-hydrocarbon receptor	Mus musculus	204-207
27551479-7	2015	Pretreatment with CH223191 at concentrations above 50 muM significantly prevents the CSC-induced activation of caspase-3/7 and externalization of phosphatidylserine in the plasma membrane.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	18-26	caspase 3	Mus musculus	111-120
27216425-8	2016	Supplementation with CH223191 or CHIR99021 attenuated most of the EOM-induced expression changes of genes involved in both AhR and wnt/beta-catenin signal pathways.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	catenin (cadherin-associated protein), beta 1	Danio rerio	135-147
26325330-10	2016	Also, treatment with CH223191 alone increased EPO and decreased hepcidin, indicating that there is a degree of constitutive AhR activation, possibly by other endogenous AhR activators.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	erythropoietin	Homo sapiens	46-49
26325330-10	2016	Also, treatment with CH223191 alone increased EPO and decreased hepcidin, indicating that there is a degree of constitutive AhR activation, possibly by other endogenous AhR activators.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	hepcidin antimicrobial peptide	Homo sapiens	64-72
26325330-10	2016	Also, treatment with CH223191 alone increased EPO and decreased hepcidin, indicating that there is a degree of constitutive AhR activation, possibly by other endogenous AhR activators.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	aryl hydrocarbon receptor	Homo sapiens	124-127
26325330-10	2016	Also, treatment with CH223191 alone increased EPO and decreased hepcidin, indicating that there is a degree of constitutive AhR activation, possibly by other endogenous AhR activators.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	aryl hydrocarbon receptor	Homo sapiens	169-172
26160521-6	2015	However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	77-85	aryl hydrocarbon receptor	Homo sapiens	62-65
26160521-6	2015	However, the halogenated aromatic hydrocarbon (HAH)-selective AhR antagonist CH223191 caused a considerable reduction in DEP-induced CYP1A1 expression indicating that this response may be due to dioxin or dioxin-like constituents in DEP.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	77-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	133-139
25781201-8	2015	AhR antagonists (alpha-naphthoflavone, CH223191) or antioxidants (N-acetyl-l-cysteine, EUK-134) attenuated 5F 203-mediated JNK and p38 activation, depending on the cell type.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	39-47	aryl hydrocarbon receptor	Homo sapiens	0-3
25781201-8	2015	AhR antagonists (alpha-naphthoflavone, CH223191) or antioxidants (N-acetyl-l-cysteine, EUK-134) attenuated 5F 203-mediated JNK and p38 activation, depending on the cell type.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	39-47	mitogen-activated protein kinase 8	Homo sapiens	123-126
25781201-8	2015	AhR antagonists (alpha-naphthoflavone, CH223191) or antioxidants (N-acetyl-l-cysteine, EUK-134) attenuated 5F 203-mediated JNK and p38 activation, depending on the cell type.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	39-47	mitogen-activated protein kinase 14	Homo sapiens	131-134
25797602-6	2015	Using the AhR competitive inhibitors alpha naphthoflavone and CH-223191, we show that phosphorylation of p38MAPK is AhR dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	62-71	aryl hydrocarbon receptor	Homo sapiens	116-119
25304490-8	2015	An AhR antagonist, CH223191, blocked this effect.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-27	aryl hydrocarbon receptor	Homo sapiens	3-6
25194622-8	2014	In contrast, decreased ALP expression by activated Ahr was completely reversed after pretreatment with an Ahr inhibitor (CH-223191) in MC3T3-E1 cell lines and primary osteoblasts on day 5.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	121-130	aryl-hydrocarbon receptor	Mus musculus	106-109
25194622-8	2014	In contrast, decreased ALP expression by activated Ahr was completely reversed after pretreatment with an Ahr inhibitor (CH-223191) in MC3T3-E1 cell lines and primary osteoblasts on day 5.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	121-130	aryl-hydrocarbon receptor	Mus musculus	51-54
24389113-7	2014	AhR inhibitors like CH223191 significantly reversed TCDD- and prochloraz-induced stimulation of ABCG2 efflux activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	20-28	aryl hydrocarbon receptor	Canis lupus familiaris	0-3
25233012-11	2014	Inhibition of CYP1A1 mRNA induction by the AhR inhibitor CH223191 indicated AhR receptor dependence this effect.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-65	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	14-20
25233012-11	2014	Inhibition of CYP1A1 mRNA induction by the AhR inhibitor CH223191 indicated AhR receptor dependence this effect.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-65	aryl hydrocarbon receptor	Homo sapiens	43-46
25233012-11	2014	Inhibition of CYP1A1 mRNA induction by the AhR inhibitor CH223191 indicated AhR receptor dependence this effect.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	57-65	aryl hydrocarbon receptor	Homo sapiens	76-79
24865613-4	2014	Previous research showed that developmental defects are rescued using an aryl hydrocarbon receptor (AHR) antagonist (CH223191), suggesting that mITP-induced toxicity was AHR-dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	117-125	aryl hydrocarbon receptor 1a	Danio rerio	73-98
24865613-4	2014	Previous research showed that developmental defects are rescued using an aryl hydrocarbon receptor (AHR) antagonist (CH223191), suggesting that mITP-induced toxicity was AHR-dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	117-125	aryl hydrocarbon receptor 1a	Danio rerio	100-103
24865613-4	2014	Previous research showed that developmental defects are rescued using an aryl hydrocarbon receptor (AHR) antagonist (CH223191), suggesting that mITP-induced toxicity was AHR-dependent.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	117-125	aryl hydrocarbon receptor 1a	Danio rerio	170-173
24389113-7	2014	AhR inhibitors like CH223191 significantly reversed TCDD- and prochloraz-induced stimulation of ABCG2 efflux activity.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	20-28	ATP binding cassette subfamily G member 2	Canis lupus familiaris	96-101
23228475-6	2013	Its induction did not appear in AHR signal-deficient cells, and was blocked by the AHR antagonist, CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	99-108	aryl hydrocarbon receptor	Homo sapiens	83-86
24755659-9	2014	Basal CYP1B1 levels were decreased by treatment with specific AhR inhibitor, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	77-85	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	6-12
24755659-9	2014	Basal CYP1B1 levels were decreased by treatment with specific AhR inhibitor, CH223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	77-85	aryl hydrocarbon receptor	Homo sapiens	62-65
24755659-10	2014	An in vitro growth assay revealed that CH223191 inhibited growth of DU145, PC3 and PC3M cells in an androgen depleted environment.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	39-47	proprotein convertase subtilisin/kexin type 1	Homo sapiens	75-78
23989051-10	2014	This restoration was prevented when PP cells were treated with CH-223191, an aryl hydrocarbon receptor inhibitor.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	63-72	aryl-hydrocarbon receptor	Mus musculus	77-102
23426015-8	2013	The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-24	aryl hydrocarbon receptor	Homo sapiens	46-71
23426015-8	2013	The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-24	aryl hydrocarbon receptor	Homo sapiens	73-76
23426015-8	2013	The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
23426015-8	2013	The addition of CH223191, an inhibitor of the aryl hydrocarbon receptor (AhR)-dependent pathway, counteracted the TCDD-induced suppression of AChE, suggesting involvement of the AhR-dependent pathway.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	16-24	aryl hydrocarbon receptor	Homo sapiens	178-181
22361730-8	2012	Both TCDD-induced ERK1/2 phosphorylation and cell proliferation were abolished by AhR small interfering RNA, AhR-specific inhibitor CH223191, Src kinase inhibitor PP2, neutralizing antibodies against matrix metalloproteinase 7, heparin-binding-EGF-like growth factor and EGFR, EGFR inhibitors (AG1478 and PD168393), and MEK1 inhibitor PD98059.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	132-140	mitogen-activated protein kinase 3	Homo sapiens	18-24
22361730-8	2012	Both TCDD-induced ERK1/2 phosphorylation and cell proliferation were abolished by AhR small interfering RNA, AhR-specific inhibitor CH223191, Src kinase inhibitor PP2, neutralizing antibodies against matrix metalloproteinase 7, heparin-binding-EGF-like growth factor and EGFR, EGFR inhibitors (AG1478 and PD168393), and MEK1 inhibitor PD98059.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	132-140	aryl hydrocarbon receptor	Homo sapiens	109-112
21967751-0	2012	Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	21-29	aryl hydrocarbon receptor	Homo sapiens	55-80
21967751-3	2012	In this study, we have characterized and used structure-activity relationship analyses of a newly synthesized library of derivatives of the potent AHR antagonist 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH223191).	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	239-247	aryl hydrocarbon receptor	Homo sapiens	147-150
22044530-10	2011	In the presence of CH-223191, an AHR antagonist, TCDD was unable to abolish 1-NP-induced p53 expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	19-28	aryl hydrocarbon receptor	Homo sapiens	33-36
21233252-6	2011	Similar results were obtained by treating adult rat ventricular myocytes with the AhR antagonist, CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	98-107	aryl hydrocarbon receptor	Rattus norvegicus	82-85
20706985-4	2010	The specific AHR-inhibitor CH-223191 abolished these effects.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	27-36	aryl hydrocarbon receptor	Homo sapiens	13-16
20634293-0	2010	CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-8	aryl hydrocarbon receptor	Homo sapiens	49-69
21525997-7	2011	The increased production of IL-22 was not dependent on AhR occupancy by residual TCDD molecules, as demonstrated in competition experiments with the specific AhR antagonist CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	173-182	interleukin 22	Homo sapiens	28-33
21525997-7	2011	The increased production of IL-22 was not dependent on AhR occupancy by residual TCDD molecules, as demonstrated in competition experiments with the specific AhR antagonist CH-223191.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	173-182	aryl hydrocarbon receptor	Homo sapiens	158-161
16540597-4	2006	In this study, by screening a chemical library composed of approximately 10,000 compounds, we identified a novel compound, 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191), that potently inhibits TCDD-induced AhR-dependent transcription.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	200-209	aryl-hydrocarbon receptor	Mus musculus	248-251
19853001-5	2009	CH-223191, an AhR antagonist, blocked the rutaecarpine-induced CYP1A1 enzyme activity and mRNA and protein expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	aryl-hydrocarbon receptor	Mus musculus	14-17
19853001-5	2009	CH-223191, an AhR antagonist, blocked the rutaecarpine-induced CYP1A1 enzyme activity and mRNA and protein expression.	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	0-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	63-69