PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33880579-0	2021	Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway.	germacrone	0-10	AKT serine/threonine kinase 1	Homo sapiens	76-79
34847832-8	2022	Moreover, germacrone protected against mitochondrial damage, limited reactive oxygen species (ROS) accumulation, and restored glutathione peroxidase (GPX) activity and GPX4 protein expression, subsequently preventing podocyte apoptosis.	germacrone	10-20	glutathione peroxidase 4	Mus musculus	168-172
34847832-12	2022	CONCLUSION: Germacrone alleviates DN progression in type I diabetes by limiting podocyte apoptosis, which was partly counteracted by miR-188-3p upregulation.	germacrone	12-22	microRNA 188	Mus musculus	133-140
33880579-8	2021	Therefore, the results of the present study demonstrated that GM induced lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway.	germacrone	62-64	AKT serine/threonine kinase 1	Homo sapiens	130-133
35156515-0	2022	Germacrone alleviates okadaic acid-induced neurotoxicity in PC12 cells via M1 muscarinic receptor-mediated Galphaq (Gq)/phospholipase C beta (PLCbeta)/ protein kinase C (PKC) signaling.	germacrone	0-10	G protein subunit alpha q	Rattus norvegicus	107-114
33880579-8	2021	Therefore, the results of the present study demonstrated that GM induced lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway.	germacrone	62-64	MDM2 proto-oncogene	Homo sapiens	134-138
33880579-0	2021	Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway.	germacrone	0-10	MDM2 proto-oncogene	Homo sapiens	80-84
33880579-0	2021	Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway.	germacrone	0-10	tumor protein p53	Homo sapiens	85-88
33880579-8	2021	Therefore, the results of the present study demonstrated that GM induced lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway.	germacrone	62-64	tumor protein p53	Homo sapiens	139-142
33880579-6	2021	GM also significantly altered the expression levels of Akt/MDM2/p53 signaling pathway-related proteins compared with the control group.	germacrone	0-2	AKT serine/threonine kinase 1	Homo sapiens	55-58
33880579-6	2021	GM also significantly altered the expression levels of Akt/MDM2/p53 signaling pathway-related proteins compared with the control group.	germacrone	0-2	MDM2 proto-oncogene	Homo sapiens	59-63
33880579-6	2021	GM also significantly altered the expression levels of Akt/MDM2/p53 signaling pathway-related proteins compared with the control group.	germacrone	0-2	tumor protein p53	Homo sapiens	64-67
33880579-7	2021	Administration of Akt activator SC79 significantly reversed GM-mediated antiproliferative, proapoptotic and pro-cell cycle arrest effects in lung cancer cells.	germacrone	60-62	AKT serine/threonine kinase 1	Homo sapiens	18-21
33244453-0	2020	Germacrone Regulates HBXIP-Mediated Cell Cycle, Apoptosis and Promotes the Formation of Autophagosomes to Inhibit the Proliferation of Gastric Cancer Cells.	germacrone	0-10	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	21-26
33402180-11	2021	Furthermore, GM up-regulated the expression of antioxidant protein Nrf2 and inhibited the expression of inflammatory response protein p-p65.	germacrone	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
33402180-11	2021	Furthermore, GM up-regulated the expression of antioxidant protein Nrf2 and inhibited the expression of inflammatory response protein p-p65.	germacrone	13-15	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	136-139
33835632-0	2021	Germacrone improves liver fibrosis by regulating the PI3K/AKT/mTOR signalling pathway.	germacrone	0-10	AKT serine/threonine kinase 1	Homo sapiens	58-61
33835632-0	2021	Germacrone improves liver fibrosis by regulating the PI3K/AKT/mTOR signalling pathway.	germacrone	0-10	mechanistic target of rapamycin kinase	Homo sapiens	62-66
33835632-5	2021	The effects of GM on liver fibrosis and its relationship with the phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway were investigated.	germacrone	15-17	protein tyrosine kinase 2 beta	Homo sapiens	103-119
33835632-5	2021	The effects of GM on liver fibrosis and its relationship with the phosphatidylinositol 3-kinase (PI3K)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway were investigated.	germacrone	15-17	AKT serine/threonine kinase 1	Homo sapiens	121-124
33835632-6	2021	In the carbon tetrachloride (CCl4 ) fibrosis-induced rat model, GM improved histological damage, inhibited the activity of hepatic alpha-smooth muscle actin (alpha-SMA), and improved serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in a dose-dependent manner.	germacrone	64-66	C-C motif chemokine ligand 4	Rattus norvegicus	29-33
33835632-6	2021	In the carbon tetrachloride (CCl4 ) fibrosis-induced rat model, GM improved histological damage, inhibited the activity of hepatic alpha-smooth muscle actin (alpha-SMA), and improved serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in a dose-dependent manner.	germacrone	64-66	actin gamma 2, smooth muscle	Rattus norvegicus	131-156
33835632-7	2021	GM potently inhibited hepatic stellate cells (HSCs) growth and epithelial-mesenchymal transition (EMT) progression, as reflected by the altered expression of proliferative (Ki-67, PCNA, and cleaved caspase-3) and EMT-related (E-cadherin and vimentin) proteins.	germacrone	0-2	proliferating cell nuclear antigen	Homo sapiens	180-184
33835632-7	2021	GM potently inhibited hepatic stellate cells (HSCs) growth and epithelial-mesenchymal transition (EMT) progression, as reflected by the altered expression of proliferative (Ki-67, PCNA, and cleaved caspase-3) and EMT-related (E-cadherin and vimentin) proteins.	germacrone	0-2	caspase 3	Homo sapiens	198-207
33835632-7	2021	GM potently inhibited hepatic stellate cells (HSCs) growth and epithelial-mesenchymal transition (EMT) progression, as reflected by the altered expression of proliferative (Ki-67, PCNA, and cleaved caspase-3) and EMT-related (E-cadherin and vimentin) proteins.	germacrone	0-2	cadherin 1	Homo sapiens	226-236
33835632-7	2021	GM potently inhibited hepatic stellate cells (HSCs) growth and epithelial-mesenchymal transition (EMT) progression, as reflected by the altered expression of proliferative (Ki-67, PCNA, and cleaved caspase-3) and EMT-related (E-cadherin and vimentin) proteins.	germacrone	0-2	vimentin	Homo sapiens	241-249
33835632-8	2021	In TGF-beta1-stimulated LX-2 cells, GM significantly inhibited the survival and activation of HSCs and induced cell apoptosis.	germacrone	36-38	transforming growth factor beta 1	Homo sapiens	3-12
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	10-12	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	10-12	mechanistic target of rapamycin kinase	Rattus norvegicus	66-70
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	10-12	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	10-12	transforming growth factor, beta 1	Rattus norvegicus	131-140
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	10-12	AKT serine/threonine kinase 1	Homo sapiens	227-230
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	10-12	mechanistic target of rapamycin kinase	Homo sapiens	231-235
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	180-182	mechanistic target of rapamycin kinase	Rattus norvegicus	66-70
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	180-182	C-C motif chemokine ligand 4	Rattus norvegicus	108-112
33835632-10	2021	Following GM treatment, the phosphorylation of the PI3K, AKT, and mTOR proteins was reduced in the liver of CCl4 -treated rats and TGF-beta1-stimulated LX-2 cells, indicating that GM may attenuate hepatic fibrosis via the PI3K/AKT/mTOR signalling pathway.	germacrone	180-182	transforming growth factor, beta 1	Rattus norvegicus	131-140
33244453-8	2020	Overexpression of HBXIP delayed the germacrone-induced cell cycle arrest, induction of apoptosis, and inhibition of autophagy.	germacrone	36-46	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	18-23
33244453-9	2020	Combined, our results indicate that germacrone suppresses gastric cancer cell proliferation by inhibiting HBXIP, and this process is related to G0/G1-phase arrest and apoptosis.	germacrone	36-46	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	106-111
33010370-4	2020	Herein, we obtained 5 sesquiterpenoids, named curzerenone, curdione, furanodienone, curcumol and germacrone with TMEM16A inhibition and revealed their mechanism of action by fluorescent and electrophysiological assays.	germacrone	97-107	anoctamin 1	Homo sapiens	113-120
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	43-53	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
32547235-11	2020	Moreover, the phosphorylation of Akt and mTOR was inhibited in germacrone-treated prostate cancer cells.	germacrone	63-73	AKT serine/threonine kinase 1	Homo sapiens	33-36
32547235-11	2020	Moreover, the phosphorylation of Akt and mTOR was inhibited in germacrone-treated prostate cancer cells.	germacrone	63-73	mechanistic target of rapamycin kinase	Homo sapiens	41-45
32547235-12	2020	Conclusion: Germacrone induced apoptosis and autophagy in prostate cancer cells by inhibiting the Akt/mTOR signaling pathway.	germacrone	12-22	AKT serine/threonine kinase 1	Homo sapiens	98-101
32547235-12	2020	Conclusion: Germacrone induced apoptosis and autophagy in prostate cancer cells by inhibiting the Akt/mTOR signaling pathway.	germacrone	12-22	mechanistic target of rapamycin kinase	Homo sapiens	102-106
32145743-9	2020	Furthermore, germacrone increased the cell viability of OGD/R-damaged PC12 cells by down-regulating the expression of LC3 protein in cells in a concentration-dependent manner.	germacrone	13-23	annexin A3	Rattus norvegicus	118-121
32145743-10	2020	More importantly, germacrone significantly inhibited the expression of PI3K III, LC3, and Beclin-1 in OGD/R-injured PC12 cells, and up-regulated the expressionof PI3K I, Akt, mTOR, and Bcl-2 proteins in cells, and this inhibited or up-regulated effect was reversed by PI3K I inhibitor (ZSTK474).	germacrone	18-28	annexin A3	Rattus norvegicus	81-84
32145743-10	2020	More importantly, germacrone significantly inhibited the expression of PI3K III, LC3, and Beclin-1 in OGD/R-injured PC12 cells, and up-regulated the expressionof PI3K I, Akt, mTOR, and Bcl-2 proteins in cells, and this inhibited or up-regulated effect was reversed by PI3K I inhibitor (ZSTK474).	germacrone	18-28	beclin 1	Rattus norvegicus	90-98
32145743-10	2020	More importantly, germacrone significantly inhibited the expression of PI3K III, LC3, and Beclin-1 in OGD/R-injured PC12 cells, and up-regulated the expressionof PI3K I, Akt, mTOR, and Bcl-2 proteins in cells, and this inhibited or up-regulated effect was reversed by PI3K I inhibitor (ZSTK474).	germacrone	18-28	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
32145743-10	2020	More importantly, germacrone significantly inhibited the expression of PI3K III, LC3, and Beclin-1 in OGD/R-injured PC12 cells, and up-regulated the expressionof PI3K I, Akt, mTOR, and Bcl-2 proteins in cells, and this inhibited or up-regulated effect was reversed by PI3K I inhibitor (ZSTK474).	germacrone	18-28	mechanistic target of rapamycin kinase	Rattus norvegicus	175-179
32145743-10	2020	More importantly, germacrone significantly inhibited the expression of PI3K III, LC3, and Beclin-1 in OGD/R-injured PC12 cells, and up-regulated the expressionof PI3K I, Akt, mTOR, and Bcl-2 proteins in cells, and this inhibited or up-regulated effect was reversed by PI3K I inhibitor (ZSTK474).	germacrone	18-28	BCL2, apoptosis regulator	Rattus norvegicus	185-190
32145743-11	2020	CONCLUSION: The above results indicated that germacrone could inhibit the autophagy effect in OGD/R injury model of PC12 cells, the mechanism of inhibition was regulated by PI3K III/Beclin-1/Bcl-2 and PI3K I/Akt/mTOR pathways, thereby improving the cell viability of PC12 cells and playing a neuroprotective role, which provided a new drug for the treatment of OGD/R.	germacrone	45-55	beclin 1	Rattus norvegicus	182-190
32145743-11	2020	CONCLUSION: The above results indicated that germacrone could inhibit the autophagy effect in OGD/R injury model of PC12 cells, the mechanism of inhibition was regulated by PI3K III/Beclin-1/Bcl-2 and PI3K I/Akt/mTOR pathways, thereby improving the cell viability of PC12 cells and playing a neuroprotective role, which provided a new drug for the treatment of OGD/R.	germacrone	45-55	BCL2, apoptosis regulator	Rattus norvegicus	191-196
32145743-11	2020	CONCLUSION: The above results indicated that germacrone could inhibit the autophagy effect in OGD/R injury model of PC12 cells, the mechanism of inhibition was regulated by PI3K III/Beclin-1/Bcl-2 and PI3K I/Akt/mTOR pathways, thereby improving the cell viability of PC12 cells and playing a neuroprotective role, which provided a new drug for the treatment of OGD/R.	germacrone	45-55	AKT serine/threonine kinase 1	Rattus norvegicus	208-211
32145743-11	2020	CONCLUSION: The above results indicated that germacrone could inhibit the autophagy effect in OGD/R injury model of PC12 cells, the mechanism of inhibition was regulated by PI3K III/Beclin-1/Bcl-2 and PI3K I/Akt/mTOR pathways, thereby improving the cell viability of PC12 cells and playing a neuroprotective role, which provided a new drug for the treatment of OGD/R.	germacrone	45-55	mechanistic target of rapamycin kinase	Rattus norvegicus	212-216
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	43-53	BCL2 apoptosis regulator	Homo sapiens	132-137
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	43-53	caspase 9	Homo sapiens	195-204
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	43-53	caspase 3	Homo sapiens	209-218
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	43-53	heat shock protein family A (Hsp70) member 5	Homo sapiens	251-256
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	43-53	caspase 7	Homo sapiens	308-317
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	94-104	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	94-104	BCL2 apoptosis regulator	Homo sapiens	132-137
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	94-104	caspase 9	Homo sapiens	195-204
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	94-104	caspase 3	Homo sapiens	209-218
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	94-104	heat shock protein family A (Hsp70) member 5	Homo sapiens	251-256
32071920-6	2020	In the study on the mechanism of action of germacrone in antiesophageal cancer, we found that germacrone increased the ratio of Bax/Bcl-2 in the cytoplasm of ESCC, resulting in the activation of Caspase-9 and Caspase-3 and decreased the expression of Grp78, thereby reducing the inhibition of Caspase-12 and Caspase-7.	germacrone	94-104	caspase 7	Homo sapiens	308-317
32071920-7	2020	In addition, we found that germacrone also inhibited STAT3 phosphorylation in a dose-dependent manner.	germacrone	27-37	signal transducer and activator of transcription 3	Homo sapiens	53-58
32071920-8	2020	In conclusion, we determined that germacrone exerted an antiesophageal effect through intrinsic apoptotic signaling pathways and by inhibiting STAT3 activity in ESCC cells.	germacrone	34-44	signal transducer and activator of transcription 3	Homo sapiens	143-148
31602228-0	2019	Germacrone cooperates with dexmedetomidine to alleviate high-fat diet-induced type 2 diabetes mellitus via upregulating AMPKalpha1 expression.	germacrone	0-10	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	120-130
32020876-7	2020	Germacrone induced cell cycle arrest in the G2/M phase via remarkably decreased expression levels of cyclin B1, cdc 2 and cdc 25c.	germacrone	0-10	cyclin B1	Homo sapiens	101-110
32020876-7	2020	Germacrone induced cell cycle arrest in the G2/M phase via remarkably decreased expression levels of cyclin B1, cdc 2 and cdc 25c.	germacrone	0-10	cyclin dependent kinase 1	Homo sapiens	112-117
32020876-7	2020	Germacrone induced cell cycle arrest in the G2/M phase via remarkably decreased expression levels of cyclin B1, cdc 2 and cdc 25c.	germacrone	0-10	cell division cycle 25C	Homo sapiens	122-129
32020876-8	2020	In addition, the treatment with germacrone induced caspase-3 activity and PARP cleavage.	germacrone	32-42	caspase 3	Homo sapiens	51-60
32020876-8	2020	In addition, the treatment with germacrone induced caspase-3 activity and PARP cleavage.	germacrone	32-42	collagen type XI alpha 2 chain	Homo sapiens	74-78
33132314-4	2020	The effect of germacrone on organic cation transporter 2 (OCT2) which is a transporter responsible for cisplatin uptake was determined.	germacrone	14-24	solute carrier family 22 member 2	Homo sapiens	28-56
33132314-4	2020	The effect of germacrone on organic cation transporter 2 (OCT2) which is a transporter responsible for cisplatin uptake was determined.	germacrone	14-24	solute carrier family 22 member 2	Homo sapiens	58-62
33132314-5	2020	Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate (3H-MPP+) uptake with IC50 of 15 microM with less effect on OCT1.	germacrone	0-10	solute carrier family 22 member 2	Homo sapiens	42-46
33132314-5	2020	Germacrone showed an inhibitory effect on OCT2-mediated methyl-4-phenylpyridinium acetate (3H-MPP+) uptake with IC50 of 15 microM with less effect on OCT1.	germacrone	0-10	solute carrier family 22 member 1	Homo sapiens	150-154
33132314-7	2020	In conclusion, germacrone prevents cisplatin-induced toxicity in renal proximal tubular cells via inhibition OCT2 transport function and reducing cisplatin accumulation.	germacrone	15-25	solute carrier family 22 member 2	Homo sapiens	109-113
31318092-10	2019	MDA levels were reduced and activities of GSH, SOD, and GSH-PX were elevated after GM treatment.	germacrone	83-85	glutathione peroxidase 1	Rattus norvegicus	56-62
31602228-14	2019	Taken together these results indicated that GM worked synergistically with DEX to attenuate symptoms of high-fat-induced T2DM, with the effect potentially involving an increase in AMPKalpha1 expression.	germacrone	44-46	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	180-190
31318092-11	2019	Caspase-3 and Bax were decreased, and Bcl-2 was increased at both messenger RNA and protein levels by GM treatment.	germacrone	102-104	caspase 3	Rattus norvegicus	0-9
31318092-11	2019	Caspase-3 and Bax were decreased, and Bcl-2 was increased at both messenger RNA and protein levels by GM treatment.	germacrone	102-104	BCL2, apoptosis regulator	Rattus norvegicus	38-43
29655913-0	2018	Germacrone reverses adriamycin resistance in human chronic myelogenous leukemia K562/ADM cells by suppressing MDR1 gene/P-glycoprotein expression.	germacrone	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
31451221-0	2019	Germacrone alleviates collagen-induced arthritis via regulating Th1/Th2 balance and NF-kappaB activation.	germacrone	0-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93
31451221-16	2019	Additionally, germacrone remarkably enhanced IkappaB expression, but suppressed p-p65 level in CIA mice.	germacrone	14-24	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	82-85
31451221-17	2019	Taken together, these results suggest that germacrone alleviated the progression of arthritis that might be related to the regulation of Th1/Th2 balance and inactivation of NF-kappaB pathway.	germacrone	43-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	173-182
29655913-0	2018	Germacrone reverses adriamycin resistance in human chronic myelogenous leukemia K562/ADM cells by suppressing MDR1 gene/P-glycoprotein expression.	germacrone	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	120-134
29655913-8	2018	Germacrone decreased adriamycin-induced expression of MDR1 mRNA and P-gp protein.	germacrone	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	54-58
29655913-8	2018	Germacrone decreased adriamycin-induced expression of MDR1 mRNA and P-gp protein.	germacrone	0-10	ATP binding cassette subfamily B member 1	Homo sapiens	68-72
29655913-9	2018	Overexpression of P-glycoprotein (P-gp) reversed the effect of germacrone on adriamycin resistance in K562/ADM cells.	germacrone	63-73	ATP binding cassette subfamily B member 1	Homo sapiens	18-32
29655913-9	2018	Overexpression of P-glycoprotein (P-gp) reversed the effect of germacrone on adriamycin resistance in K562/ADM cells.	germacrone	63-73	ATP binding cassette subfamily B member 1	Homo sapiens	34-38
29655913-10	2018	In conclusion, germacrone reversed adriamycin resistance in human chronic myelogenous leukemia K562/ADM cells by suppressing MDR1 gene/P-gp expression.	germacrone	15-25	ATP binding cassette subfamily B member 1	Homo sapiens	125-129
29655913-10	2018	In conclusion, germacrone reversed adriamycin resistance in human chronic myelogenous leukemia K562/ADM cells by suppressing MDR1 gene/P-gp expression.	germacrone	15-25	ATP binding cassette subfamily B member 1	Homo sapiens	135-139
27917474-8	2017	In particular, GM down-regulates the expression of early adipogenesis-related genes (e.g. KLF4, KLF5, C/EBP-beta and C/EBP-delta) and major adipogenesis-related genes (C/EBP-alpha and PPAR-gamma).	germacrone	15-17	Kruppel-like factor 4 (gut)	Mus musculus	90-94
29218943-14	2017	Compared with model group, the contents of PGI2, NO, T-NOS, t-PA, SOD, GSH-Px and Bcl-2 mRNA expressions were increased after treated with germacrone.	germacrone	139-149	plasminogen activator, tissue type	Homo sapiens	60-77
29218943-14	2017	Compared with model group, the contents of PGI2, NO, T-NOS, t-PA, SOD, GSH-Px and Bcl-2 mRNA expressions were increased after treated with germacrone.	germacrone	139-149	BCL2 apoptosis regulator	Homo sapiens	82-87
29218943-15	2017	The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone.	germacrone	132-142	serpin family E member 1	Homo sapiens	16-21
29218943-15	2017	The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone.	germacrone	132-142	endothelin 1	Homo sapiens	23-27
29218943-15	2017	The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone.	germacrone	132-142	interleukin 6	Homo sapiens	29-33
29218943-15	2017	The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone.	germacrone	132-142	tumor necrosis factor	Homo sapiens	35-44
29218943-15	2017	The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone.	germacrone	132-142	BCL2 associated X, apoptosis regulator	Homo sapiens	62-65
29218943-15	2017	The contents of PAI-1, ET-1, IL-6, TNF-alpha, TXB2, LDH, MDA, Bax mRNA and Caspase-3 mRNA expressions were lower after treated with germacrone.	germacrone	132-142	caspase 3	Homo sapiens	75-84
27917474-8	2017	In particular, GM down-regulates the expression of early adipogenesis-related genes (e.g. KLF4, KLF5, C/EBP-beta and C/EBP-delta) and major adipogenesis-related genes (C/EBP-alpha and PPAR-gamma).	germacrone	15-17	Kruppel-like factor 5	Mus musculus	96-100
27917474-8	2017	In particular, GM down-regulates the expression of early adipogenesis-related genes (e.g. KLF4, KLF5, C/EBP-beta and C/EBP-delta) and major adipogenesis-related genes (C/EBP-alpha and PPAR-gamma).	germacrone	15-17	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	102-112
27917474-8	2017	In particular, GM down-regulates the expression of early adipogenesis-related genes (e.g. KLF4, KLF5, C/EBP-beta and C/EBP-delta) and major adipogenesis-related genes (C/EBP-alpha and PPAR-gamma).	germacrone	15-17	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	117-128
27917474-8	2017	In particular, GM down-regulates the expression of early adipogenesis-related genes (e.g. KLF4, KLF5, C/EBP-beta and C/EBP-delta) and major adipogenesis-related genes (C/EBP-alpha and PPAR-gamma).	germacrone	15-17	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	168-179
27917474-8	2017	In particular, GM down-regulates the expression of early adipogenesis-related genes (e.g. KLF4, KLF5, C/EBP-beta and C/EBP-delta) and major adipogenesis-related genes (C/EBP-alpha and PPAR-gamma).	germacrone	15-17	peroxisome proliferator activated receptor gamma	Mus musculus	184-194
27917474-9	2017	Furthermore, GM increases the protein levels of phosphorylated AMP-activated protein kinase alpha (AMPKalpha), phosphorylated acetyl-coenzyme A carboxylase (ACC) and carnitine palmitoyltransferase (CPT1).	germacrone	13-15	carnitine palmitoyltransferase 1b, muscle	Mus musculus	198-202
24889088-4	2014	Treatment of the U87 and U251 human glioma cell lines with germacrone inhibited the cell proliferation in a dose- and time-dependent manner as assessed by MTT assay, while significantly lower effects were observed on normal human astrocytes.	germacrone	59-69	small nucleolar RNA, C/D box 87	Homo sapiens	17-20
25399081-3	2014	Results showed that germacrone treatment significantly decreased the expression of pro-inflammatory cytokines IL-6 and TNF-alpha.	germacrone	20-30	interleukin 6	Rattus norvegicus	110-114
25399081-3	2014	Results showed that germacrone treatment significantly decreased the expression of pro-inflammatory cytokines IL-6 and TNF-alpha.	germacrone	20-30	tumor necrosis factor	Rattus norvegicus	119-128
25399081-4	2014	Meanwhile, the expression of anti-inflammatory mediators TGF-beta1 and IL-10 was obviously increased following germacrone administration.	germacrone	111-121	transforming growth factor, beta 1	Rattus norvegicus	57-66
25399081-4	2014	Meanwhile, the expression of anti-inflammatory mediators TGF-beta1 and IL-10 was obviously increased following germacrone administration.	germacrone	111-121	interleukin 10	Rattus norvegicus	71-76
25399081-8	2014	At the molecular level, we found that germacrone treatment promoted the expression of claudin-4 both in vivo and in vitro as shown by real time PCR and western blot.	germacrone	38-48	claudin 4	Rattus norvegicus	86-95
25399081-9	2014	Collectively, our study demonstrated that germacrone protected neonatal rats against LPS-induced ALI partially by modulation of claudin-4.	germacrone	42-52	claudin 4	Rattus norvegicus	128-137
25289068-6	2014	Furthermore, the results from the western blot analysis demonstrated that augmenting ADR treatment with germacrone resulted in a reduction of anti-apoptotic protein expression levels (bcl-2) and enhancement of pro-apoptotic protein expression levels (p53 and bax) in MCF-7/ADR cells compared with the levels achieved by treatment with ADR alone.	germacrone	104-114	BCL2 apoptosis regulator	Homo sapiens	184-189
25289068-6	2014	Furthermore, the results from the western blot analysis demonstrated that augmenting ADR treatment with germacrone resulted in a reduction of anti-apoptotic protein expression levels (bcl-2) and enhancement of pro-apoptotic protein expression levels (p53 and bax) in MCF-7/ADR cells compared with the levels achieved by treatment with ADR alone.	germacrone	104-114	tumor protein p53	Homo sapiens	251-254
25289068-6	2014	Furthermore, the results from the western blot analysis demonstrated that augmenting ADR treatment with germacrone resulted in a reduction of anti-apoptotic protein expression levels (bcl-2) and enhancement of pro-apoptotic protein expression levels (p53 and bax) in MCF-7/ADR cells compared with the levels achieved by treatment with ADR alone.	germacrone	104-114	BCL2 associated X, apoptosis regulator	Homo sapiens	259-262
25289068-7	2014	In addition, germacrone significantly reduced the expression of P-glycoprotein via the inhibition of the multidrug resistance 1 (MDR1) gene promoter.	germacrone	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	64-78
25289068-7	2014	In addition, germacrone significantly reduced the expression of P-glycoprotein via the inhibition of the multidrug resistance 1 (MDR1) gene promoter.	germacrone	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	105-127
25289068-7	2014	In addition, germacrone significantly reduced the expression of P-glycoprotein via the inhibition of the multidrug resistance 1 (MDR1) gene promoter.	germacrone	13-23	ATP binding cassette subfamily B member 1	Homo sapiens	129-133
27573551-0	2016	Germacrone Inhibits Estrogen Receptor alpha-Mediated Transcription in MCF-7 Breast Cancer Cells.	germacrone	0-10	estrogen receptor 1	Homo sapiens	20-43
27573551-5	2016	Here, we demonstrated that germacrone inhibits ERalpha-mediated gene expression at the transcriptional level in MCF-7 cells.	germacrone	27-37	estrogen receptor 1	Homo sapiens	47-54
27573551-6	2016	Germacrone inhibits the recruitment of ERalpha to the estrogen response element on chromatin and consequently compromises the binding of switch/sucrose non-fermentable chromatin remodeling complex and RNA polymerase II to target gene promoter, thereby inhibiting the estrogen-induced chromatin accessibility.	germacrone	0-10	estrogen receptor 1	Homo sapiens	39-46
27573551-8	2016	Our results not only provide substantial molecular mechanism of germacrone on ERalpha-mediated signaling in breast cancer cells but also demonstrate the benefits of germacrone as a combination therapy with other drugs for the treatment of breast cancer.	germacrone	64-74	estrogen receptor 1	Homo sapiens	78-85
24889088-5	2014	Flow cytometric analysis and DNA fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl-2.	germacrone	61-71	tumor protein p53	Homo sapiens	151-154
24889088-5	2014	Flow cytometric analysis and DNA fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl-2.	germacrone	61-71	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
24889088-5	2014	Flow cytometric analysis and DNA fragmentation revealed that germacrone promoted apoptosis of glioma cells, associated with an increased expression of p53 and bax and decreased expression of bcl-2.	germacrone	61-71	BCL2 apoptosis regulator	Homo sapiens	191-196
24889088-6	2014	Furthermore, flow cytometric cell cycle analysis revealed that germacrone induced G1 phase arrest, associated with an obvious decrease in the expression of cyclin D1 and CDK2 and an increased expression of p21.	germacrone	63-73	cyclin D1	Homo sapiens	156-165
24889088-6	2014	Furthermore, flow cytometric cell cycle analysis revealed that germacrone induced G1 phase arrest, associated with an obvious decrease in the expression of cyclin D1 and CDK2 and an increased expression of p21.	germacrone	63-73	cyclin dependent kinase 2	Homo sapiens	170-174
24889088-6	2014	Furthermore, flow cytometric cell cycle analysis revealed that germacrone induced G1 phase arrest, associated with an obvious decrease in the expression of cyclin D1 and CDK2 and an increased expression of p21.	germacrone	63-73	cyclin dependent kinase inhibitor 1A	Homo sapiens	206-209
23771657-0	2013	Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway.	germacrone	0-10	Janus kinase 2	Homo sapiens	85-89
23850985-0	2013	Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.	germacrone	44-54	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-85
23850985-1	2013	Misclassification of Curcuma species (family Zingiberaceae) may lead to unwanted human exposure to Curcuma elata sesquiterpenes zederone and germacrone which have caused hepatotoxicity and changes in CYP expression in laboratory animals.	germacrone	141-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	200-203
23850985-6	2013	CYP inhibition studies with pooled human liver microsomes (HLMs) indicated that zederone and germacrone moderately inhibited CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 muM.	germacrone	93-103	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3
23850985-6	2013	CYP inhibition studies with pooled human liver microsomes (HLMs) indicated that zederone and germacrone moderately inhibited CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 muM.	germacrone	93-103	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	125-131
23850985-6	2013	CYP inhibition studies with pooled human liver microsomes (HLMs) indicated that zederone and germacrone moderately inhibited CYP2B6 and CYP3A4 activities in vitro, with IC50 values below 10 muM.	germacrone	93-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	136-142
23771657-0	2013	Germacrone induces apoptosis in human hepatoma HepG2 cells through inhibition of the JAK2/STAT3 signalling pathway.	germacrone	0-10	signal transducer and activator of transcription 3	Homo sapiens	90-95
23771657-2	2013	In this study, we investigated the relationship between the JAK2/STAT3 signalling pathway and germacrone-induced apoptosis in HepG2 cells.	germacrone	94-104	Janus kinase 2	Homo sapiens	60-64
23771657-2	2013	In this study, we investigated the relationship between the JAK2/STAT3 signalling pathway and germacrone-induced apoptosis in HepG2 cells.	germacrone	94-104	signal transducer and activator of transcription 3	Homo sapiens	65-70
23771657-3	2013	HepG2 cells were incubated with germacrone for 24 h, the protein expression of p-STAT3, STAT3, p-JAK2 and JAK2 was detected by Western Blotting, and RT-PCR was used to determine the expression of STAT3, p53, Bcl-2 and Bax at transcriptional levels.	germacrone	32-42	Janus kinase 2	Homo sapiens	106-110
23771657-7	2013	The results showed that germacrone exposure decreased p-STAT3 and p-JAK2 and regulated expression of p53 and Bcl-2 family members at the same time.	germacrone	24-34	signal transducer and activator of transcription 3	Homo sapiens	56-61
23771657-7	2013	The results showed that germacrone exposure decreased p-STAT3 and p-JAK2 and regulated expression of p53 and Bcl-2 family members at the same time.	germacrone	24-34	Janus kinase 2	Homo sapiens	68-72
23771657-7	2013	The results showed that germacrone exposure decreased p-STAT3 and p-JAK2 and regulated expression of p53 and Bcl-2 family members at the same time.	germacrone	24-34	tumor protein p53	Homo sapiens	101-104
23771657-7	2013	The results showed that germacrone exposure decreased p-STAT3 and p-JAK2 and regulated expression of p53 and Bcl-2 family members at the same time.	germacrone	24-34	BCL2 apoptosis regulator	Homo sapiens	109-114
23771657-8	2013	Moreover, IL-6 enhanced the activation of the JAK2/STAT3 signalling pathway and therefore attenuated the germacrone-induced apoptosis.	germacrone	105-115	interleukin 6	Homo sapiens	10-14
23771657-8	2013	Moreover, IL-6 enhanced the activation of the JAK2/STAT3 signalling pathway and therefore attenuated the germacrone-induced apoptosis.	germacrone	105-115	Janus kinase 2	Homo sapiens	46-50
23771657-8	2013	Moreover, IL-6 enhanced the activation of the JAK2/STAT3 signalling pathway and therefore attenuated the germacrone-induced apoptosis.	germacrone	105-115	signal transducer and activator of transcription 3	Homo sapiens	51-56
23771657-9	2013	Suppression of JAK2/STAT3 signalling pathway by AG490, an inhibitor of JAK2, resulted in apoptosis and an increase in ROS in response to germacrone exposure.	germacrone	137-147	Janus kinase 2	Homo sapiens	15-19
23771657-9	2013	Suppression of JAK2/STAT3 signalling pathway by AG490, an inhibitor of JAK2, resulted in apoptosis and an increase in ROS in response to germacrone exposure.	germacrone	137-147	signal transducer and activator of transcription 3	Homo sapiens	20-25
23771657-9	2013	Suppression of JAK2/STAT3 signalling pathway by AG490, an inhibitor of JAK2, resulted in apoptosis and an increase in ROS in response to germacrone exposure.	germacrone	137-147	Janus kinase 2	Homo sapiens	71-75
23771657-10	2013	We therefore conclude that germacrone induces apoptosis through the JAK2/STAT3 signalling pathway.	germacrone	27-37	Janus kinase 2	Homo sapiens	68-72
23771657-10	2013	We therefore conclude that germacrone induces apoptosis through the JAK2/STAT3 signalling pathway.	germacrone	27-37	signal transducer and activator of transcription 3	Homo sapiens	73-78
23117090-6	2013	In the meantime, the up-regulation of p53 and reactive oxygen species increase were observed, which suggested that germacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone.	germacrone	115-125	tumor protein p53	Homo sapiens	38-41
23117090-6	2013	In the meantime, the up-regulation of p53 and reactive oxygen species increase were observed, which suggested that germacrone might be a new potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone.	germacrone	115-125	tumor protein p53	Homo sapiens	284-287
21497161-5	2011	Furthermore, germacrone treatment significantly increased Bok expression and cytochrome c release from mitochondria without affecting Bcl-2, Bcl-xL, Bax, and Bim protein expressions.	germacrone	13-23	BCL2 family apoptosis regulator BOK	Homo sapiens	58-61
21497161-5	2011	Furthermore, germacrone treatment significantly increased Bok expression and cytochrome c release from mitochondria without affecting Bcl-2, Bcl-xL, Bax, and Bim protein expressions.	germacrone	13-23	cytochrome c, somatic	Homo sapiens	77-89
21497161-6	2011	In addition, germacrone treatment induced caspase-3, 7, 9, PARP cleavage.	germacrone	13-23	caspase 3	Homo sapiens	42-57
21497161-6	2011	In addition, germacrone treatment induced caspase-3, 7, 9, PARP cleavage.	germacrone	13-23	collagen type XI alpha 2 chain	Homo sapiens	59-63
23117090-4	2013	Flow cytometric analysis revealed that germacrone induced G2/M arrest in the cell cycle progression that was associated with an obvious decrease in the protein expression of cyclin B1 and its activating partner CDK1 with concomitant inductions of p21.	germacrone	39-49	cyclin B1	Homo sapiens	174-183
23117090-4	2013	Flow cytometric analysis revealed that germacrone induced G2/M arrest in the cell cycle progression that was associated with an obvious decrease in the protein expression of cyclin B1 and its activating partner CDK1 with concomitant inductions of p21.	germacrone	39-49	cyclin dependent kinase 1	Homo sapiens	211-215
23117090-4	2013	Flow cytometric analysis revealed that germacrone induced G2/M arrest in the cell cycle progression that was associated with an obvious decrease in the protein expression of cyclin B1 and its activating partner CDK1 with concomitant inductions of p21.	germacrone	39-49	cyclin dependent kinase inhibitor 1A	Homo sapiens	247-250