PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17146965-0	2006	The role of the hydrophobic group on ring A of chalcones in the inhibition of interleukin-5.	Chalcones	47-56	interleukin 5	Homo sapiens	78-91
17146965-1	2006	Novel chalcones were found as potent inhibitors of interleukin-5 (11-5).	Chalcones	6-15	interleukin 5	Homo sapiens	51-64
17112240-6	2006	In particular, the presence of a hydroxyl group at C-4" in the A ring was an important determinant of the inhibitory activity of chalcones.	Chalcones	129-138	complement C4A (Rodgers blood group)	Homo sapiens	51-54
17125223-4	2006	On the basis of the data obtained, flavanones and chalcones with isoprenyl groups may be considered as a new class of PTP1B inhibitors.	Chalcones	50-59	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	118-123
16650843-1	2006	Some chalcones, such as hydroxychalcones have been reported previously to inhibit major pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and reactive oxygen species production by suppressing inducible enzyme expression via inhibition of the mitogen-activated protein kinase (MAPK) pathway and nuclear translocation of critical transcription factors.	Chalcones	5-14	tumor necrosis factor	Mus musculus	171-198
16639703-3	2006	The proposed method permits the identification of hop polyphenols (flavonoids glycosides and chalcones), bitter acids (alpha-acids and beta-acids), and their oxidation products.	Chalcones	93-102	HOP homeobox	Homo sapiens	50-53
16798002-1	2006	A group of (E)-1,3-diphenylprop-2-en-1-one derivatives (chalcones) possessing a MeSO(2)NH, or N(3), COX-2 pharmacophore at the para-position of the C-1 phenyl ring were synthesized using a facile stereoselective Claisen-Schmidt condensation reaction.	Chalcones	56-65	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
16650843-1	2006	Some chalcones, such as hydroxychalcones have been reported previously to inhibit major pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and reactive oxygen species production by suppressing inducible enzyme expression via inhibition of the mitogen-activated protein kinase (MAPK) pathway and nuclear translocation of critical transcription factors.	Chalcones	5-14	tumor necrosis factor	Mus musculus	200-209
16557332-1	2006	Seventeen organocatalyts were tested for their ability to catalyst the addition of thiophenols to chalcones in [bmim]PF6.	Chalcones	98-107	sperm associated antigen 17	Homo sapiens	117-120
16202584-3	2005	In particular, sulfonamide chalcones 17-20 had more potent alpha-glucosidase inhibitory activity than aminated chalcone 13-16.	Chalcones	27-36	sucrase-isomaltase	Homo sapiens	59-76
16291820-2	2006	Chalcones exert their cytoprotective actions via activation of specific transcriptional factors and upregulation of endogenous defensive pathways, such as phase II enzymes and the stress protein heme oxygenase-1 (HO-1).	Chalcones	0-9	heme oxygenase 1	Mus musculus	195-211
16291820-2	2006	Chalcones exert their cytoprotective actions via activation of specific transcriptional factors and upregulation of endogenous defensive pathways, such as phase II enzymes and the stress protein heme oxygenase-1 (HO-1).	Chalcones	0-9	heme oxygenase 1	Mus musculus	213-217
16508194-3	2006	Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4" or 5" in chalcone plays a key role in determining the potency of PPAR-gamma activation.	Chalcones	10-19	complement C4A (Rodgers blood group)	Homo sapiens	141-144
16508194-3	2006	Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4" or 5" in chalcone plays a key role in determining the potency of PPAR-gamma activation.	Chalcones	10-19	complement C4A (Rodgers blood group)	Homo sapiens	176-179
16367960-1	2006	Aureusidin synthase, a polyphenol oxidase (PPO), specifically catalyzes the oxidative formation of aurones from chalcones, which are plant flavonoids, and is responsible for the yellow coloration of snapdragon (Antirrhinum majus) flowers.	Chalcones	112-121	type one serine/threonine protein phosphatase 2	Arabidopsis thaliana	43-46
17191997-2	2005	Both the benzothiazepines and chalcones were evaluated as DPPH free-radical scavengers and as inhibitors of cholinesterases, urease, and alpha-glucosidase.	Chalcones	30-39	sucrase-isomaltase	Homo sapiens	137-154
16055334-8	2005	Due to their planar conformations, the pyrazoles are typically less active than the corresponding chalcones, which adopt angular conformations similar to CA-4.	Chalcones	98-107	carbonic anhydrase 4	Mus musculus	154-158
16508194-3	2006	Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4" or 5" in chalcone plays a key role in determining the potency of PPAR-gamma activation.	Chalcones	10-19	peroxisome proliferator activated receptor gamma	Homo sapiens	246-256
11148027-5	2001	Here, we show by multidimensional NMR spectroscopy that chalcones (1,3-diphenyl-2-propen-1-ones) are MDM2 inhibitors that bind to a subsite of the p53 binding cleft of human MDM2.	Chalcones	56-65	MDM2 proto-oncogene	Homo sapiens	101-105
15231412-0	2004	Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers.	Chalcones	0-9	tyrosinase	Homo sapiens	20-30
12794878-4	2003	CAD of the metal complexes, especially [Co(II) (chalcone-H) 2,2"-bipyridine](+), allowed the most effective differentiation of the isomeric chalcones with several diagnostic fragment ions appearing upon activation of the metal complexes.	Chalcones	140-149	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-46
12590456-9	2003	This is the first study indicating that glabrene and isoliquiritigenin exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, suggesting that isoflavenes and chalcones may serve as candidates for skin-lightening agents.	Chalcones	185-194	tyrosinase	Homo sapiens	110-120
12413856-0	2002	Development of 3D-QSAR models for 5-lipoxygenase antagonists: chalcones.	Chalcones	62-71	arachidonate 5-lipoxygenase	Homo sapiens	34-48
12413856-2	2002	In order to identify the essential structural and physicochemical requirements in terms of common biophoric sites (pharmacophore) and secondary sites for binding and interacting with 5-lipoxygenase, a series of 51 compounds of chalcones has been used for the development of 3D-QSAR models on APEX-3D expert system.	Chalcones	227-236	arachidonate 5-lipoxygenase	Homo sapiens	183-197
11814858-2	2002	All fluorinated chalcones tested showed 5-lipoxygenase inhibition on rat basophilic leukemia-1 (RBL-1) cells and inhibitory action on Fe(3+)-ADP induced NADPH-dependent lipid peroxidation in rat liver microsomes.	Chalcones	16-25	arachidonate 5-lipoxygenase	Rattus norvegicus	40-54
15720190-10	2005	Small molecules that have been reported to disrupt the p53-MDM2 binding, thereby enhancing p53 activity to elicit anticancer effects include the following: synthetic chalcones, norbornane derivatives, cis-imidazoline derivatives (Nutlins), a pyrazolidinedione sulfonamide and 1,4-benzodiazepine-2,5-diones, as well as tryptophan derivatives.	Chalcones	166-175	MDM2 proto-oncogene	Homo sapiens	59-63
15720190-10	2005	Small molecules that have been reported to disrupt the p53-MDM2 binding, thereby enhancing p53 activity to elicit anticancer effects include the following: synthetic chalcones, norbornane derivatives, cis-imidazoline derivatives (Nutlins), a pyrazolidinedione sulfonamide and 1,4-benzodiazepine-2,5-diones, as well as tryptophan derivatives.	Chalcones	166-175	tumor protein p53	Homo sapiens	91-94
15895683-0	2005	Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.	Chalcones	133-142	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-63
15895683-0	2005	Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.	Chalcones	133-142	butyrylcholinesterase	Homo sapiens	65-103
15895683-2	2005	It was observed that some of these compounds have the potential to inhibit acetylcholinesterase, whereas others show activity against butyrylcholinesterase, depending on the substitution pattern at the two aromatic rings of these chalcones.	Chalcones	230-239	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-95
15895683-2	2005	It was observed that some of these compounds have the potential to inhibit acetylcholinesterase, whereas others show activity against butyrylcholinesterase, depending on the substitution pattern at the two aromatic rings of these chalcones.	Chalcones	230-239	butyrylcholinesterase	Homo sapiens	134-155
11148027-5	2001	Here, we show by multidimensional NMR spectroscopy that chalcones (1,3-diphenyl-2-propen-1-ones) are MDM2 inhibitors that bind to a subsite of the p53 binding cleft of human MDM2.	Chalcones	56-65	tumor protein p53	Homo sapiens	147-150
11148027-5	2001	Here, we show by multidimensional NMR spectroscopy that chalcones (1,3-diphenyl-2-propen-1-ones) are MDM2 inhibitors that bind to a subsite of the p53 binding cleft of human MDM2.	Chalcones	56-65	MDM2 proto-oncogene	Homo sapiens	174-178
11205867-0	2001	Chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities.	Chalcones	0-9	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	49-84
11205867-1	2001	Chalcones were tested for estimating anti-aromatase, anti-3beta-hydroxysteroid dehydrogenase delta5/delta4 isomerase (3beta-HSD) and anti-17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities in human placental microsomes.	Chalcones	0-9	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	53-116
11205867-2	2001	In the present study, we have demonstrated for the first time that chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities: these enzymes being considered as important targets in the metabolic pathways of human mammary hormone-dependent cells.	Chalcones	67-76	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	116-151
11055382-9	2000	The level of expression of Bax in cells treated with either of these chalcones was markedly elevated and the level of Bcl-XL decreased slightly.	Chalcones	69-78	BCL2-associated X protein	Mus musculus	27-30
11055382-11	2000	From these results, it seems that the pathway by which the chalcones induce apoptosis may be independent of p53 and dependent on proteins of the Bcl-2 family.	Chalcones	59-68	transformation related protein 53, pseudogene	Mus musculus	108-111
11055382-11	2000	From these results, it seems that the pathway by which the chalcones induce apoptosis may be independent of p53 and dependent on proteins of the Bcl-2 family.	Chalcones	59-68	B cell leukemia/lymphoma 2	Mus musculus	145-150
9487544-6	1998	RESULTS: Some chalcones showed strong inhibitory effects on the release of beta-glucuronidase and histamine from rat peritoneal mast cells stimulated with compound 48/80.	Chalcones	14-23	glucuronidase, beta	Rattus norvegicus	75-93
10737704-0	2000	Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.	Chalcones	11-20	crystallin, zeta	Mus musculus	51-68
10814343-1	2000	[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors.	Chalcones	34-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	186-191
9767651-0	1998	Halogenated chalcones with high-affinity binding to P-glycoprotein: potential modulators of multidrug resistance.	Chalcones	12-21	ATP binding cassette subfamily B member 1	Homo sapiens	52-66
9767651-3	1998	In the present study, a series of halogenated chalcones was prepared to further explore the structural requirements for the P-gp modulation.	Chalcones	46-55	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
9767651-4	1998	Four halogenated chalcones have been synthesized and evaluated as potential modulators of P-gp-mediated multidrug resistance of cancer cells by in vitro assays using a purified recombinant domain of the transporter containing the modulator binding site.	Chalcones	17-26	ATP binding cassette subfamily B member 1	Homo sapiens	90-94
9871729-2	1998	In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide.	Chalcones	10-19	arachidonate 5-lipoxygenase	Homo sapiens	67-81
9487544-7	1998	Almost all chalcones and 4"-hydroxyflavanone exhibited potent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP).	Chalcones	11-20	glucuronidase, beta	Rattus norvegicus	99-117
9448101-8	1997	However, inhibitory activity against ornithine decarboxylase (ODC) was commonly observed in both naturally occurring and synthetic antitumorigenic chalcones.	Chalcones	147-156	ornithine decarboxylase, structural 1	Mus musculus	37-60
9448101-8	1997	However, inhibitory activity against ornithine decarboxylase (ODC) was commonly observed in both naturally occurring and synthetic antitumorigenic chalcones.	Chalcones	147-156	ornithine decarboxylase, structural 1	Mus musculus	62-65
9374426-5	1997	Analysis of structure-activity relationships showed certain chemical structures to be important for the inhibition of GSH-RD: (a) C-5 and C-7 hydroxylations in the A-ring, a carbonyl group at C-4, and the B-ring attached to C-2 in flavonoids; (b) C-2" and C-4" hydroxylations in chalcones; and (c) C-6 and C-7 hydroxylations in coumarins.	Chalcones	279-288	complement C7	Homo sapiens	138-141
9366096-2	1997	From DGAT inhibitory activity-guided fractionation, two chalcones were isolated.	Chalcones	56-65	diacylglycerol O-acyltransferase 1	Homo sapiens	5-9
34832930-1	2021	To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed.	Chalcones	93-103	monoamine oxidase B	Mus musculus	43-48
1772594-7	1991	A number of other naturally occurring plant phenolics including chalcones and gossypol also inhibit avian MLCK and wheat CDPK.	Chalcones	64-73	calcium-dependent protein kinase 19	Triticum aestivum	121-125
32920430-0	2020	Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors.	Chalcones	0-9	monoamine oxidase B	Homo sapiens	55-74
34762841-0	2022	Natural chalcones elicit formation of specialized pro-resolving mediators and related 15-lipoxygenase products in human macrophages.	Chalcones	8-17	arachidonate 15-lipoxygenase	Homo sapiens	86-101
34946631-4	2021	Among these bioactive compounds, flavonoids represent a huge natural class with different categories such as flavones, flavonols, isoflavones, flavan-3-ols, flavanones and chalcones that display antioxidant and tyrosinase inhibitor activities with a diversity of mechanistic approaches.	Chalcones	172-181	tyrosinase	Homo sapiens	211-221
33430657-0	2021	Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.	Chalcones	17-26	amine oxidase [flavin-containing] B	Chlorocebus sabaeus	42-61
33430657-0	2021	Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations.	Chalcones	17-26	acetylcholinesterase	Chlorocebus sabaeus	66-86
32890999-3	2020	In this work, we prepared a series of chalcones and 2"-aminochalcones, which were tested against AChE and BACE-1 enzymes and on the aggregation of Abeta.	Chalcones	38-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	97-101
32890999-3	2020	In this work, we prepared a series of chalcones and 2"-aminochalcones, which were tested against AChE and BACE-1 enzymes and on the aggregation of Abeta.	Chalcones	38-47	beta-secretase 1	Homo sapiens	106-112
32890999-3	2020	In this work, we prepared a series of chalcones and 2"-aminochalcones, which were tested against AChE and BACE-1 enzymes and on the aggregation of Abeta.	Chalcones	38-47	amyloid beta precursor protein	Homo sapiens	147-152
32890999-5	2020	We have found that the majority of chalcones having the amino group are able to inhibit BACE-1, which was not observed for chalcones without this group.	Chalcones	35-44	beta-secretase 1	Homo sapiens	88-94
32890999-5	2020	We have found that the majority of chalcones having the amino group are able to inhibit BACE-1, which was not observed for chalcones without this group.	Chalcones	123-132	beta-secretase 1	Homo sapiens	88-94
34309224-4	2021	Based on observations that chalcones can stimulate BMP4 signaling pathways, we hypothesized their utility in cardiac mesoderm induction.	Chalcones	27-36	bone morphogenetic protein 4	Homo sapiens	51-55
34832913-0	2021	Inhibition of XPO-1 Mediated Nuclear Export through the Michael-Acceptor Character of Chalcones.	Chalcones	86-95	exportin 1	Homo sapiens	14-19
33744807-0	2021	Chalcones and their B-aryl analogues as myeloperoxidase inhibitors: In silico, in vitro and ex vivo investigations.	Chalcones	0-9	myeloperoxidase	Homo sapiens	40-55
34496319-4	2021	Chalcones induced intrinsic and extrinsic apoptosis, resulting in activation of caspase-3 and DNA fragmentation.	Chalcones	0-9	caspase 3	Homo sapiens	80-89
34397324-0	2021	Development of 2D, 3D-QSAR and Pharmacophore Modeling of Chalcones for the Inhibition of Monoamine Oxidase B.	Chalcones	57-66	monoamine oxidase B	Homo sapiens	89-108
34397324-3	2021	METHODS: With the experimental results of about 70 chalcone derivatives, we further developed a pharmacophore modelling, and 2D and 3D- QSAR analyses of these reported chalcones for MAO-B inhibition.	Chalcones	168-177	monoamine oxidase B	Homo sapiens	182-187
34075985-3	2021	In this work, we report the design and synthesis of anthraquinone-based metal-organic cages (MOCs) for the (2 + 2) photocycloaddition of chalcones to generate syn-HH cyclobutanes.	Chalcones	137-146	synemin	Homo sapiens	159-162
34205272-0	2021	Chalcones as Promising Antitumor Agents by Targeting the p53 Pathway: An Overview and New Insights in Drug-Likeness.	Chalcones	0-9	transformation related protein 53	Mus musculus	57-60
34205272-4	2021	Chalcones are naturally occurring compounds widely described as potential antitumor agents through several mechanisms, including those involving the p53 pathway.	Chalcones	0-9	transformation related protein 53	Mus musculus	149-152
34205272-6	2021	In this work, a literature review of natural and synthetic chalcones and their analogues potentially interfering with p53 pathway is presented.	Chalcones	59-68	transformation related protein 53	Mus musculus	118-121
34205272-7	2021	Moreover, in silico studies of drug-likeness of chalcones recognized as p53-MDM2 interaction inhibitors were accomplished considering molecular descriptors, biophysiochemical properties, and pharmacokinetic parameters in comparison with those from p53-MDM2 in clinical trials.	Chalcones	48-57	transformation related protein 53	Mus musculus	72-75
34205272-7	2021	Moreover, in silico studies of drug-likeness of chalcones recognized as p53-MDM2 interaction inhibitors were accomplished considering molecular descriptors, biophysiochemical properties, and pharmacokinetic parameters in comparison with those from p53-MDM2 in clinical trials.	Chalcones	48-57	transformed mouse 3T3 cell double minute 2	Mus musculus	76-80
34205272-8	2021	With this review, we expect to guide the design of new and more effective chalcones targeting the p53 pathway.	Chalcones	74-83	transformation related protein 53	Mus musculus	98-101
34477522-8	2021	Chalcones, generally, are potential and more selective towards MAO-B inhibitions whereas pyrazolines derived from chalcones turned into selective towards MAO-A inhibitions due to maybe the presence of two nitrogen heteroatoms.	Chalcones	0-9	monoamine oxidase B	Homo sapiens	63-68
34477522-8	2021	Chalcones, generally, are potential and more selective towards MAO-B inhibitions whereas pyrazolines derived from chalcones turned into selective towards MAO-A inhibitions due to maybe the presence of two nitrogen heteroatoms.	Chalcones	114-123	monoamine oxidase A	Homo sapiens	154-159
35124513-4	2022	Molecular and ensemble docking predicted that these chalcones would establish multiple interactions with residues in the catalytic and allosteric sites of ZIKV NS2B-NS3 protease, and in the allosteric site of the NS5 RNA-dependent RNA-polymerase (RdRp).	Chalcones	52-61	KRAS proto-oncogene, GTPase	Homo sapiens	165-168
33877504-9	2021	Indeed, flavone, isoflavone aglycones, non-prenylated chalcones and glycycoumarin were found to be TRPM8 inhibitors.	Chalcones	54-63	transient receptor potential cation channel subfamily M member 8	Homo sapiens	99-104
34262643-0	2021	Promising Non-cytotoxic Monosubstituted Chalcones to Target Monoamine Oxidase-B.	Chalcones	40-49	monoamine oxidase B	Homo sapiens	60-79
35548879-0	2022	Synthesis and in vitro studies for structure-based design of novel chalcones as antitubercular agents targeting InhA.	Chalcones	67-76	NADH-dependent enoyl-[ACP] reductase	Mycobacterium tuberculosis H37Rv	112-116
35208952-0	2022	EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones.	Chalcones	89-98	epidermal growth factor receptor	Homo sapiens	0-4
35208952-0	2022	EGFR and COX-2 Dual Inhibitor: The Design, Synthesis, and Biological Evaluation of Novel Chalcones.	Chalcones	89-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	9-14
35208174-0	2022	Analogues of Natural Chalcones as Efficient Inhibitors of AKR1C3.	Chalcones	21-30	aldo-keto reductase family 1 member C3	Homo sapiens	58-64
35208174-3	2022	Based on the literature and preliminary results, we aimed to study and optimise the efficiency of a series of chalcones to inhibit androgen-converting AKR1C3, known to promote prostate cancer.	Chalcones	110-119	aldo-keto reductase family 1 member C3	Homo sapiens	151-157
35208174-12	2022	Favourable substitutions that enhanced AKR1C3 inhibition of chalcones were identified.	Chalcones	60-69	aldo-keto reductase family 1 member C3	Homo sapiens	39-45
33744807-1	2021	In the present study, a series of chalcones and their B-aryl analogues were prepared and evaluate as inhibitors of myeloperoxidase (MPO) chlorinating activity, using in vitro and ex vivo assays.	Chalcones	34-43	myeloperoxidase	Homo sapiens	115-130
33744807-1	2021	In the present study, a series of chalcones and their B-aryl analogues were prepared and evaluate as inhibitors of myeloperoxidase (MPO) chlorinating activity, using in vitro and ex vivo assays.	Chalcones	34-43	myeloperoxidase	Homo sapiens	132-135
33527835-3	2021	Microbial transformation of BCA (1) and BCB (2) with the endophytic fungus Aspergillus niger KCCM 60332 yielded 10 previously undescribed chalcones (1a-1e and 2a-2e).	Chalcones	138-147	B cell linker	Homo sapiens	28-31
33691555-0	2021	Activation of Nrf2 signaling pathway by natural and synthetic chalcones: a therapeutic road map for oxidative stress.	Chalcones	62-71	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
33691555-3	2021	This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to activate Nrf2 signaling pathway, expression of Nrf2-regulated antioxidant genes, induce cytoprotective proteins and upregulate multidrug resistance-associated proteins.	Chalcones	67-76	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
33691555-3	2021	This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to activate Nrf2 signaling pathway, expression of Nrf2-regulated antioxidant genes, induce cytoprotective proteins and upregulate multidrug resistance-associated proteins.	Chalcones	67-76	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
33691555-3	2021	This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to activate Nrf2 signaling pathway, expression of Nrf2-regulated antioxidant genes, induce cytoprotective proteins and upregulate multidrug resistance-associated proteins.	Chalcones	67-76	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
33691555-3	2021	This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to activate Nrf2 signaling pathway, expression of Nrf2-regulated antioxidant genes, induce cytoprotective proteins and upregulate multidrug resistance-associated proteins.	Chalcones	111-120	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
33691555-3	2021	This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to activate Nrf2 signaling pathway, expression of Nrf2-regulated antioxidant genes, induce cytoprotective proteins and upregulate multidrug resistance-associated proteins.	Chalcones	111-120	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
33691555-3	2021	This review will discuss the interactions of natural and synthetic chalcones with Nrf2 signaling.Areas covered:Chalcones are reportedly found to activate Nrf2 signaling pathway, expression of Nrf2-regulated antioxidant genes, induce cytoprotective proteins and upregulate multidrug resistance-associated proteins.	Chalcones	111-120	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
33795997-10	2021	Moreover, the test chalcones (3a, 3f & 3 g) antagonized the effect of 4-acetaminophenol and thus, raised the catalase (CAT) and superoxide dismutase (SOD) while decreased the malondialdehyde (MDA) in experimental animals.	Chalcones	19-28	catalase	Rattus norvegicus	109-117
33795997-10	2021	Moreover, the test chalcones (3a, 3f & 3 g) antagonized the effect of 4-acetaminophenol and thus, raised the catalase (CAT) and superoxide dismutase (SOD) while decreased the malondialdehyde (MDA) in experimental animals.	Chalcones	19-28	catalase	Rattus norvegicus	119-122
33743158-0	2021	Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders.	Chalcones	23-32	monoamine oxidase B	Homo sapiens	49-54
33743158-0	2021	Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders.	Chalcones	23-32	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
33743158-0	2021	Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders.	Chalcones	23-32	beta-secretase 1	Homo sapiens	66-72
33653970-7	2021	These results show for the first time that certain chalcones could interrupt the activation of the NLRP3 inflammasome in H. pylori-infected THP-1 cells.	Chalcones	51-60	NLR family pyrin domain containing 3	Homo sapiens	99-104
33244799-0	2021	Design, synthesis, biological evaluation, and docking studies of some novel chalcones as selective COX-2 inhibitors.	Chalcones	76-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	99-104
33244799-1	2021	A new series of chalcones (1-9) possessing an SO2 CH3 COX-2 pharmacophore at the para position of the C-1 phenyl ring was synthesized via the Claisen-Schmidt condensation reaction and examined for their inhibition potential against cyclooxygenase (COX) enzymes.	Chalcones	16-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-59
33571810-0	2021	Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors.	Chalcones	70-79	monoamine oxidase B	Homo sapiens	104-123
33571810-3	2021	In the current work, we focused our attention on the understanding of theoretical models that may predict the MAO-B activity and selectivity of new chalcones.	Chalcones	148-157	monoamine oxidase B	Homo sapiens	110-115
33263770-9	2021	Thus, this study identifies hydroxylated chalcones as AhR agonists with potential for these phytochemicals to impact AhR mediated colonic pathways.	Chalcones	41-50	aryl hydrocarbon receptor	Homo sapiens	54-57
33387581-3	2021	In this review, we discussed the antioxidant potential of chalcones and elucidated the mechanisms of pathways and proteins such as carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), aldose reductase, SLGT-2, and Nrf2 that are targeted by antidiabetic chalcones.	Chalcones	58-67	sucrase-isomaltase	Homo sapiens	181-198
33263770-9	2021	Thus, this study identifies hydroxylated chalcones as AhR agonists with potential for these phytochemicals to impact AhR mediated colonic pathways.	Chalcones	41-50	aryl hydrocarbon receptor	Homo sapiens	117-120
33476864-3	2021	Methoxylated phenyl-based chalcones 2a-l and coumarin-based chalcones 3a-f were synthesized and compared for their inhibition of COX-2 enzyme and nitric oxide production suppression.	Chalcones	60-69	cytochrome c oxidase II, mitochondrial	Mus musculus	129-134
33476864-4	2021	Methoxylated phenyl-based chalcones showed better inhibition to COX-2 enzyme and nitric oxide suppression than the coumarin-based chalcones.	Chalcones	26-35	cytochrome c oxidase II, mitochondrial	Mus musculus	64-69
33451160-4	2021	In the present study, we assessed several representatives of phytochemical categories consisting of alkaloids, chalcones and isothiocyanates for their inhibitory activity to nuclear localization of beta-catenin-an important event for Wnt/beta-catenin pathway activation, in lung cancer cell lines.	Chalcones	111-120	catenin beta 1	Homo sapiens	198-210
33451160-4	2021	In the present study, we assessed several representatives of phytochemical categories consisting of alkaloids, chalcones and isothiocyanates for their inhibitory activity to nuclear localization of beta-catenin-an important event for Wnt/beta-catenin pathway activation, in lung cancer cell lines.	Chalcones	111-120	catenin beta 1	Homo sapiens	238-250
33263770-6	2021	The activity of AhR-active chalcones was confirmed by determining their effects in AhR-deficient, Caco2 cells.	Chalcones	27-36	aryl hydrocarbon receptor	Homo sapiens	16-19
33263770-6	2021	The activity of AhR-active chalcones was confirmed by determining their effects in AhR-deficient, Caco2 cells.	Chalcones	27-36	aryl hydrocarbon receptor	Homo sapiens	83-86
33263770-8	2021	Simulation and modeling studies of hydroxylated chalcones confirmed their interactions with the AhR ligand binding domain and was consistent with their structure-dependent activity as AhR ligands.	Chalcones	48-57	aryl hydrocarbon receptor	Homo sapiens	96-99
33263770-8	2021	Simulation and modeling studies of hydroxylated chalcones confirmed their interactions with the AhR ligand binding domain and was consistent with their structure-dependent activity as AhR ligands.	Chalcones	48-57	aryl hydrocarbon receptor	Homo sapiens	184-187
33644592-0	2021	Bicyclic Chalcones as Mitotic Inhibitors for Overcoming Androgen Receptor-Independent and Multidrug-Resistant Prostate Cancer.	Chalcones	9-18	androgen receptor	Homo sapiens	56-73
33387885-6	2021	Therefore, it was observed that, regarding the interactions of chalcones with Main protease (Mpro), the chalcone N-(4"[(2E)-3-(4-flurophenyl)-1-(phenyl)prop-2-en-1-one]) acetamide (PAAPF) has the potential for coupling in the same region as the natural inhibitor FJC through strong hydrogen bonding.	Chalcones	63-72	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	93-97
33387581-3	2021	In this review, we discussed the antioxidant potential of chalcones and elucidated the mechanisms of pathways and proteins such as carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), aldose reductase, SLGT-2, and Nrf2 that are targeted by antidiabetic chalcones.	Chalcones	58-67	aldo-keto reductase family 1 member B	Homo sapiens	201-217
33387581-3	2021	In this review, we discussed the antioxidant potential of chalcones and elucidated the mechanisms of pathways and proteins such as carbohydrate digestive enzymes (alpha-amylase and alpha-glucosidase), aldose reductase, SLGT-2, and Nrf2 that are targeted by antidiabetic chalcones.	Chalcones	58-67	NFE2 like bZIP transcription factor 2	Homo sapiens	231-235
32663559-0	2020	Screening of plant derived chalcones on the inhibition of potato apyrase: Potential protein biotechnological applications in health.	Chalcones	27-36	apyrase	Solanum tuberosum	65-72
32924264-0	2020	Selected 1,3-benzodioxine-containing chalcones as multipotent monoamine oxidase and acetylcholinesterase inhibitors.	Chalcones	37-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-104
32924264-1	2020	Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors.	Chalcones	0-9	butyrylcholinesterase	Homo sapiens	96-110
32924264-1	2020	Chalcones are considered effective templates for the development of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors.	Chalcones	0-9	butyrylcholinesterase	Homo sapiens	112-115
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	CD8a molecule	Homo sapiens	97-100
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	membrane metalloendopeptidase	Homo sapiens	105-109
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	monoamine oxidase A	Homo sapiens	152-157
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	monoamine oxidase B	Homo sapiens	159-164
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-186
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	188-192
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	butyrylcholinesterase	Homo sapiens	199-220
32924264-2	2020	The present work describes the syntheses of selected 1,3-benzodioxine-containing chalcones (CD3, CD8 and CD10), and their inhibitory activities against MAO-A, MAO-B, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	Chalcones	81-90	butyrylcholinesterase	Homo sapiens	222-226
32663559-4	2020	In this study, we investigated the in vitro potential of synthetic chalcones on the inhibition of potato apyrase purified from Solanum tuberosum.	Chalcones	67-76	apyrase	Solanum tuberosum	105-112
32663559-6	2020	Five out of the eight chemically synthetized chalcones analyzed in this study showed significant inhibition of the apyrase activity.	Chalcones	45-54	apyrase	Solanum tuberosum	115-122
32663559-9	2020	Our results with the potato apyrase inhibition with the synthetic chalcones suggest that these compounds may use as potential lead candidates for the treatment of some diseases associated with nucleotides.	Chalcones	66-75	apyrase	Solanum tuberosum	28-35
32705910-0	2020	Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B.	Chalcones	66-75	monoamine oxidase B	Homo sapiens	124-143
32867308-0	2020	Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.	Chalcones	139-148	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-69
33212830-8	2020	The calculated binding free energies of the O-methylated flavonoids (1 and 4-6) and chalcones (2 and 3) to MAO-A matched closely with the trend in the experimental IC50"s.	Chalcones	84-93	monoamine oxidase A	Homo sapiens	107-112
32975953-0	2020	Natural and Semisynthetic Chalcones as Dual FLT3 and Microtubule Polymerization Inhibitors.	Chalcones	26-35	fms related receptor tyrosine kinase 3	Homo sapiens	44-48
32975953-4	2020	Herein the identification of a dual FLT3/microtubule polymerization inhibitor, chalcone 4 (2"-allyloxy-4,4"-dimethoxychalcone), is reported through screening of 15 related chalcones for differential antiproliferative activity in leukemia cell lines dependent on FLT3-ITD (MV-4-11) or BCR-ABL (K562) oncogenes and by subsequent screening for mitotic inducers in the HCT116 cell line.	Chalcones	172-181	fms related receptor tyrosine kinase 3	Homo sapiens	36-40
32975953-5	2020	Three natural chalcones (1-3) were found to be differentially more potent toward the MV-4-11 (FLT3-ITD) cell line compared to the K562 (BCR-ABL) cell line.	Chalcones	14-23	fms related receptor tyrosine kinase 3	Homo sapiens	94-98
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Chalcones	0-9	amyloid beta precursor protein	Homo sapiens	55-65
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Chalcones	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Chalcones	0-9	kelch like ECH associated protein 1	Homo sapiens	169-175
33223599-1	2021	Abstract: To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15-36 and 37-41) and structurally related compounds (42-47) are reported.	Chalcones	175-184	ferredoxin reductase	Rattus norvegicus	28-46
33223599-1	2021	Abstract: To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15-36 and 37-41) and structurally related compounds (42-47) are reported.	Chalcones	175-184	ferredoxin reductase	Rattus norvegicus	48-50
33182305-5	2020	Among the 20 fluorinated chalcones, compound A3/B3 bearing an indole ring attached to the olefinic carbon have been proved to possess the most antimicrobial activity compared to the standard drugs without showing cytotoxicity on human normal liver cell line (L02).	Chalcones	25-34	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	45-50
32939670-3	2020	The present study was based on the known abilities of chalcones to act as molecular scaffolds that selectively inhibit MAO-B with the added advantage of binding reversibly.	Chalcones	54-63	monoamine oxidase B	Mus musculus	119-124
32867308-0	2020	Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some N-Substituted-4-Phenothiazine-Chalcones.	Chalcones	139-148	beta-secretase 1	Homo sapiens	74-80
32867308-2	2020	Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition.	Chalcones	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82
32867308-2	2020	Chalcones are the flavonoid derivatives with diverse bioactivities, including AChE and BACE-1 inhibition.	Chalcones	0-9	beta-secretase 1	Homo sapiens	87-93
32867308-3	2020	In this study, a series of N-substituted-4-phenothiazine-chalcones was synthesized and tested for AChE and BACE-1 inhibitory activities.	Chalcones	57-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	98-102
32299731-4	2020	The present study expands on the discovery of dual MAO-B/COMT inhibitors by synthesising additional nitrocatechol derivatives of chalcones which include heterocyclic derivatives, and converting them to the corresponding pyrazoline derivatives.	Chalcones	129-138	monoamine oxidase B	Homo sapiens	51-56
32678233-0	2020	A small library of chalcones induce liver cancer cell death through Akt phosphorylation inhibition.	Chalcones	19-28	AKT serine/threonine kinase 1	Homo sapiens	68-71
32678233-10	2020	Hence the chalcones induced apoptotic cell death pathway through NF[Formula: see text]B-p65 inhibition.	Chalcones	10-19	RELA proto-oncogene, NF-kB subunit	Homo sapiens	88-91
32678233-13	2020	Therefore, our results indicated that these chalcones can be considered as candidates for liver cancer therapeutics particularly when PI3K/Akt pathway involved in tumor development.	Chalcones	44-53	AKT serine/threonine kinase 1	Homo sapiens	139-142
32510085-5	2020	These prenylated chalcones acted as the antagonists of the glucocorticoid receptor and inhibited the binding of dexamethasone to this receptor and its subsequent nuclear translocation.	Chalcones	17-26	nuclear receptor subfamily 3, group C, member 1	Mus musculus	59-82
32510085-6	2020	In addition, the chalcones suppressed the phosphorylation of p38 and FoxO3a as the upstream factors for ubiquitin ligases.	Chalcones	17-26	forkhead box O3	Mus musculus	69-75
32299731-1	2020	Literature reports that chalcones inhibit the monoamine oxidase (MAO) enzymes, mostly with specificity for the MAO-B isoform, while nitrocatechol compounds are established inhibitors of catechol-O-methyltransferase (COMT).	Chalcones	24-33	monoamine oxidase A	Rattus norvegicus	65-68
32299731-1	2020	Literature reports that chalcones inhibit the monoamine oxidase (MAO) enzymes, mostly with specificity for the MAO-B isoform, while nitrocatechol compounds are established inhibitors of catechol-O-methyltransferase (COMT).	Chalcones	24-33	monoamine oxidase B	Homo sapiens	111-116
32299731-4	2020	The present study expands on the discovery of dual MAO-B/COMT inhibitors by synthesising additional nitrocatechol derivatives of chalcones which include heterocyclic derivatives, and converting them to the corresponding pyrazoline derivatives.	Chalcones	129-138	catechol-O-methyltransferase	Homo sapiens	57-61
32299731-1	2020	Literature reports that chalcones inhibit the monoamine oxidase (MAO) enzymes, mostly with specificity for the MAO-B isoform, while nitrocatechol compounds are established inhibitors of catechol-O-methyltransferase (COMT).	Chalcones	24-33	catechol-O-methyltransferase	Homo sapiens	216-220
32299731-8	2020	The results indicated that the pyrazoline derivatives (IC50 = 0.048-0.21 microM) are more potent COMT inhibitors than the chalcones (IC50 = 0.14-0.29 microM).	Chalcones	122-131	catechol-O-methyltransferase	Rattus norvegicus	97-101
32044354-0	2020	Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor.	Chalcones	35-49	ATP binding cassette subfamily B member 1	Homo sapiens	66-71
32276831-0	2020	Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling.	Chalcones	0-9	KRAS proto-oncogene, GTPase	Homo sapiens	97-102
32276831-5	2020	Here, we discovered chalcones 1 and 8 exhibit anti-K-Ras activity, and show that the compounds mislocalize K-Ras from the PM and block oncogenic K-Ras signal output.	Chalcones	20-29	KRAS proto-oncogene, GTPase	Homo sapiens	51-56
32276831-5	2020	Here, we discovered chalcones 1 and 8 exhibit anti-K-Ras activity, and show that the compounds mislocalize K-Ras from the PM and block oncogenic K-Ras signal output.	Chalcones	20-29	KRAS proto-oncogene, GTPase	Homo sapiens	107-112
32276831-5	2020	Here, we discovered chalcones 1 and 8 exhibit anti-K-Ras activity, and show that the compounds mislocalize K-Ras from the PM and block oncogenic K-Ras signal output.	Chalcones	20-29	KRAS proto-oncogene, GTPase	Homo sapiens	107-112
32044354-0	2020	Biological evaluation of non-basic chalcone CYB-2 as a dual ABCG2/ABCB1 inhibitor.	Chalcones	35-49	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	60-65
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	43-52	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	58-63
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	43-52	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	156-161
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	43-52	ATP binding cassette subfamily B member 1	Homo sapiens	162-167
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	43-52	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	156-161
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	43-52	ATP binding cassette subfamily B member 1	Homo sapiens	241-246
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	118-132	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	58-63
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	118-132	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	156-161
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	118-132	ATP binding cassette subfamily B member 1	Homo sapiens	162-167
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	118-132	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	156-161
32044354-5	2020	The previous studies showed that non-basic chalcones were ABCG2-specific inhibitors; however, we found that non-basic chalcone CYB-2 can be developed as an ABCG2/ABCB1 dual inhibitor to overcome MDR in cancers that co-express both ABCG2 and ABCB1.	Chalcones	118-132	ATP binding cassette subfamily B member 1	Homo sapiens	241-246
31879284-6	2020	We also looked into potential mechanism of action for a chalcone that produced relatively large effects on lifespan and were able to implicate the activity of stress-response regulators NRF2/skn-1 and SESN/sesn-1 in its mechanism of action.	Chalcones	56-64	NFE2 like bZIP transcription factor 2	Homo sapiens	186-190
32451094-6	2020	Furthermore, docking simulations indicated that two chalcones (isobavachalcone and bavachalcone) could interact with the key residues located in the catalytic cavity of PL via hydrogen binding and hydrophobic interactions.	Chalcones	52-61	pancreatic lipase	Homo sapiens	169-171
32451094-7	2020	Collectively, these finding provided solid evidence to support that Fructus Psoraleae contained bioactive compounds with lipid-lowering effects via targeting PL, and also suggested that the chalcones in Fructus Psoraleae could be used as ideal leading compounds to develop novel PL inhibitors.	Chalcones	190-199	pancreatic lipase	Homo sapiens	158-160
32451094-7	2020	Collectively, these finding provided solid evidence to support that Fructus Psoraleae contained bioactive compounds with lipid-lowering effects via targeting PL, and also suggested that the chalcones in Fructus Psoraleae could be used as ideal leading compounds to develop novel PL inhibitors.	Chalcones	190-199	pancreatic lipase	Homo sapiens	279-281
32110945-4	2020	Among the chalcones, compound 28 showed potent antibacterial (MIC = 1 microg/mL) and antioxidant activities (IC50 = 5 +- 1 microg/mL).	Chalcones	10-19	growth differentiation factor 15	Homo sapiens	62-69
31707018-1	2020	Five chalcone-based molecules denominated by C-3 ((E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one), C-4 ((E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one), C-5 ((E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one), C-6 ((E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one) and C-7 ((E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one) were synthesized by Claisen-Schmidt reaction in solution of NaOH in water/ethanol 2:1.	Chalcones	5-13	complement C3	Homo sapiens	45-48
31707018-1	2020	Five chalcone-based molecules denominated by C-3 ((E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one), C-4 ((E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one), C-5 ((E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one), C-6 ((E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one) and C-7 ((E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one) were synthesized by Claisen-Schmidt reaction in solution of NaOH in water/ethanol 2:1.	Chalcones	5-13	complement C5	Homo sapiens	151-154
31707018-1	2020	Five chalcone-based molecules denominated by C-3 ((E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one), C-4 ((E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one), C-5 ((E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one), C-6 ((E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one) and C-7 ((E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one) were synthesized by Claisen-Schmidt reaction in solution of NaOH in water/ethanol 2:1.	Chalcones	5-13	complement C6	Homo sapiens	226-229
31707018-1	2020	Five chalcone-based molecules denominated by C-3 ((E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one), C-4 ((E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one), C-5 ((E)-1-(benzo[d][1,3]dioxol-5-yl)-3-(4-methoxyphenyl)prop-2-en-1-one), C-6 ((E)-3-(naphthalen-1-yl)-1-phenylprop-2-en-1-one) and C-7 ((E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one) were synthesized by Claisen-Schmidt reaction in solution of NaOH in water/ethanol 2:1.	Chalcones	5-13	complement C7	Homo sapiens	284-287
32111098-3	2020	However, the involvement of both the NO and the ERalpha pathways for the beneficial vascular effects of chalcones has never been demonstrated.	Chalcones	104-113	estrogen receptor 1 (alpha)	Mus musculus	48-55
32111098-7	2020	We were able to demonstrate that the vasorelaxant effect of two highly active chalcones was either ERalpha-dependent and NO-independent or ERalpha-independent and NO-dependent.	Chalcones	78-87	estrogen receptor 1 (alpha)	Mus musculus	99-106
31887452-0	2020	Structure based modification of chalcone analogue activates Nrf2 in the human retinal pigment epithelial cell line ARPE-19.	Chalcones	32-40	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
31887452-3	2020	In the present study, we designed and synthesized a novel chalcone analogue, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), as a Nrf2 activator.	Chalcones	58-66	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
32054115-7	2020	Furthermore, ectopic expression of AtPAP1 evoked expression of early and late biosynthetic genes of the general phenylpropanoid and flavonoid pathways that include phenylalanine ammonia-lyase (PAL), cinnamate-4-hydroxylase (C4H), 4-coumarate CoA ligase (4CL), chalcone isomerase (CHI), and quinate hydroxycinnamoyl transferase (HCT), which suggests these genes might be transcriptional targets of AtPAP1 in black nightshade.	Chalcones	260-268	phosphatidic acid phosphatase 1	Arabidopsis thaliana	35-41
31879284-6	2020	We also looked into potential mechanism of action for a chalcone that produced relatively large effects on lifespan and were able to implicate the activity of stress-response regulators NRF2/skn-1 and SESN/sesn-1 in its mechanism of action.	Chalcones	56-64	sestrin 1	Homo sapiens	206-212
32026770-0	2020	Novel Polymethoxylated Chalcones as potential compounds against KRAS-Mutant Colorectal Cancers.	Chalcones	6-32	KRAS proto-oncogene, GTPase	Homo sapiens	64-68
31654520-0	2020	Vasorelaxant Effect of Novel Nitric Oxide-Hydrogen Sulfide Donor Chalcone in isolated rat aorta: Involvement of cGMP mediated sGC and Potassium Channel Activation.	Chalcones	65-73	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	126-129
32831235-3	2020	Single crystals of (E)-1-(1H-pyrrol-2-yl)-3-(thiophen-2-yl)prop-2-en-1-one were grown, allowing structural comparisons between the heterocyclic chalcones and (2E)-1,3-diphenylprop-2-en-1-one, trivially known as trans-chalcone.	Chalcones	144-153	small nucleolar RNA, H/ACA box 73A	Homo sapiens	19-24
32064388-3	2020	The mechanism of binding of chalcone with bovine serum albumin (BSA) was determined by multispectroscopic techniques and computational methods.	Chalcones	28-36	albumin	Homo sapiens	49-62
32026770-3	2020	Therefore, we designed and synthesized novel chalcone analogs, small organic molecules, to investigate their effects on KRAS-mutant CRC cells.	Chalcones	45-53	KRAS proto-oncogene, GTPase	Homo sapiens	120-124
31878304-0	2019	Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Abeta Fibril Assembly.	Chalcones	10-19	amyloid beta precursor protein	Homo sapiens	71-76
31670201-0	2020	A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model.	Chalcones	8-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	31-35
31670201-5	2020	In this study, we synthesized novel chalcone derivatives and found a highly potent Nrf2 activator, compound 20a.	Chalcones	36-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
31810914-0	2019	New Chalcone Derivative Inhibits ABCB1 in Multidrug Resistant T-cell Lymphoma and Colon Adenocarcinoma Cells.	Chalcones	4-12	ATP binding cassette subfamily B member 1	Homo sapiens	33-38
31817828-0	2019	The Chalcone Lonchocarpin Inhibits Wnt/beta-Catenin Signaling and Suppresses Colorectal Cancer Proliferation.	Chalcones	4-12	catenin beta 1	Homo sapiens	39-51
31817828-3	2019	In this context, we identified the chalcone lonchocarpin isolated from Lonchocarpus sericeus as a Wnt/beta-catenin pathway inhibitor, both in vitro and in vivo.	Chalcones	35-56	catenin beta 1	Homo sapiens	102-114
31808389-0	2021	Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study.	Chalcones	32-40	butyrylcholinesterase	Homo sapiens	5-19
31808389-1	2021	BACKGROUND: Chalcones, originated from natural product, have been broadly studied their biological activity against various proteins which at the molecular level, are responsible for the progress of the diseases in cancer (e.g. kinases), inflammation (oxidoreductases), atherosclerosis (cathepsins receptor), and diabetes (e.g. alpha-glucosidase).	Chalcones	12-21	sucrase-isomaltase	Homo sapiens	328-345
31808389-2	2021	OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Chalcones	33-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143
31808389-2	2021	OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Chalcones	33-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-149
31808389-2	2021	OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Chalcones	33-41	butyrylcholinesterase	Homo sapiens	155-176
31808389-2	2021	OBJECTIVE: Here we synthesize 10 chalcone derivatives to be evaluated their in vitro enzymatic inhibition activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).	Chalcones	33-41	butyrylcholinesterase	Homo sapiens	178-182
31808389-5	2021	Molecular docking studies predicted that this activity might be due to the interaction of the chalcones with important amino acid residues in the binding site of AChE such as SER200 and in that of BChE such as TRP82, SER198, TRP430, TYR440, LEU286 and VAL288.	Chalcones	94-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	162-166
31808389-5	2021	Molecular docking studies predicted that this activity might be due to the interaction of the chalcones with important amino acid residues in the binding site of AChE such as SER200 and in that of BChE such as TRP82, SER198, TRP430, TYR440, LEU286 and VAL288.	Chalcones	94-103	butyrylcholinesterase	Homo sapiens	197-201
31808389-6	2021	CONCLUSION: Chalcone can be used as the scaffold for cholinesterase inhibitor, in particularly either fluorine or nitro group to be augmented at the para-position of Ring B, whereas the hydrophobic chain is necessary at the meta-position of Ring B.	Chalcones	12-20	butyrylcholinesterase	Homo sapiens	53-67
31810914-3	2019	The study aimed at evaluating the impact of a new chalcone derivative (1C) on multidrug resistant cell lines, focusing on P-glycoprotein (P-gp, ABCB1) inhibition, as well as 1C-doxorubicin interaction in vitro.	Chalcones	50-58	ATP binding cassette subfamily B member 1	Homo sapiens	122-136
29860891-0	2019	The behavior of some chalcones on acetylcholinesterase and carbonic anhydrase activity.	Chalcones	21-30	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-54
31117836-0	2019	Antiproliferative activity and p53 upregulation effects of chalcones on human breast cancer cells.	Chalcones	59-68	tumor protein p53	Homo sapiens	31-34
31827483-6	2019	Additionally, the low expression of the tea caffeine synthase gene (TCS) involved in caffeine biosynthesis and the chalcone synthase genes CHS1, CHS2, and CHS3, the chalcone isomerase gene CHI, the flavonoid 3",5"-hydroxylase genes F3"5"H1 and F3"5"H2, and the anthocyanidin reductase genes ANR1 and ANR2 involved in the flavonoid pathway is related to the reduction in alkaloid and catechin levels in "Xiaoxueya" albino leaves.	Chalcones	115-123	lysosomal trafficking regulator	Homo sapiens	139-143
31827483-6	2019	Additionally, the low expression of the tea caffeine synthase gene (TCS) involved in caffeine biosynthesis and the chalcone synthase genes CHS1, CHS2, and CHS3, the chalcone isomerase gene CHI, the flavonoid 3",5"-hydroxylase genes F3"5"H1 and F3"5"H2, and the anthocyanidin reductase genes ANR1 and ANR2 involved in the flavonoid pathway is related to the reduction in alkaloid and catechin levels in "Xiaoxueya" albino leaves.	Chalcones	165-173	lysosomal trafficking regulator	Homo sapiens	139-143
31606547-0	2019	Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors.	Chalcones	58-67	monoamine oxidase B	Rattus norvegicus	92-97
29860891-6	2019	We also investigated the inhibition of seven chalcones toward hCA I, hCA II, and AChE.	Chalcones	45-54	carbonic anhydrase 1	Homo sapiens	62-67
29860891-6	2019	We also investigated the inhibition of seven chalcones toward hCA I, hCA II, and AChE.	Chalcones	45-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
29860891-7	2019	The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE.	Chalcones	4-13	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	70-86
29860891-7	2019	The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE.	Chalcones	4-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96
29860891-7	2019	The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE.	Chalcones	4-13	carbonic anhydrase 1	Homo sapiens	70-75
29860891-7	2019	The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE.	Chalcones	4-13	carbonic anhydrase 2	Homo sapiens	80-86
29860891-7	2019	The chalcones were effective inhibitors of the cytosolic CA isoforms (hCA I and hCA II) and AChE with Ki values in the range of 1.83-7.05 muM for hCA I, 0.59-5.50 muM for hCA II, and 0.61-86.11 muM for AChE.	Chalcones	4-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	202-206
31338101-1	2019	Anthocyanins are distributed ubiquitously to terrestrial plants and chalcone isomerase (CHI) catalyzes the stereospecific isomerization of chalcones - a committed step in the anthocyanin biosynthesis pathway.	Chalcones	139-148	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	68-86
31325783-0	2019	Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance.	Chalcones	47-56	ATP binding cassette subfamily B member 1	Homo sapiens	73-87
31550148-1	2019	The luminescent chalcone gold(I) conjugates [Au(PPh3)(AN3E)]PF6(1) and [Au(SIMes)(AN3E)]PF6 (2) (AN3E = (E)-3-(9-anthracenyl)-1-(4-pyridyl)propenone; SIMes = N,N"-dimesitylimidazolidin-2-ylidene; Mes = 2,4,6-trimethylphenyl)) were prepared and characterized; complex 1 was also characterized by X-ray crystallography.	Chalcones	16-24	caveolin 1	Homo sapiens	48-52
31550148-1	2019	The luminescent chalcone gold(I) conjugates [Au(PPh3)(AN3E)]PF6(1) and [Au(SIMes)(AN3E)]PF6 (2) (AN3E = (E)-3-(9-anthracenyl)-1-(4-pyridyl)propenone; SIMes = N,N"-dimesitylimidazolidin-2-ylidene; Mes = 2,4,6-trimethylphenyl)) were prepared and characterized; complex 1 was also characterized by X-ray crystallography.	Chalcones	16-24	sperm associated antigen 17	Homo sapiens	60-63
31550148-1	2019	The luminescent chalcone gold(I) conjugates [Au(PPh3)(AN3E)]PF6(1) and [Au(SIMes)(AN3E)]PF6 (2) (AN3E = (E)-3-(9-anthracenyl)-1-(4-pyridyl)propenone; SIMes = N,N"-dimesitylimidazolidin-2-ylidene; Mes = 2,4,6-trimethylphenyl)) were prepared and characterized; complex 1 was also characterized by X-ray crystallography.	Chalcones	16-24	sperm associated antigen 17	Homo sapiens	88-91
31620227-0	2019	Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase.	Chalcones	0-17	arachidonate 5-lipoxygenase	Homo sapiens	87-101
31620227-6	2019	SAR indicated that the presence of methoxy/methyl either in the vicinity of chalcone or both thiazole and chalcone contributed to the synergistic inhibitory effect.	Chalcones	76-84	sarcosine dehydrogenase	Homo sapiens	0-3
31620227-6	2019	SAR indicated that the presence of methoxy/methyl either in the vicinity of chalcone or both thiazole and chalcone contributed to the synergistic inhibitory effect.	Chalcones	106-114	sarcosine dehydrogenase	Homo sapiens	0-3
31414099-3	2019	In the present work, a panel of chalcones bearing hydroxy, methoxy, methyl, nitro, chloro, fluoro and bromo substituents were evaluated against alpha-amylase and alpha-glucosidase activities, most of them for the first time.	Chalcones	32-41	sucrase-isomaltase	Homo sapiens	162-179
31414099-6	2019	Chalcones holding nitro groups and chloro substituents, together with a hydroxy group in the chalcone scaffold, showed strong inhibition of the alpha-glucosidase activity.	Chalcones	0-9	sucrase-isomaltase	Homo sapiens	144-161
31803395-3	2019	Among them, the chalcones 2a and 2b were the most COX-2 selective derivatives (S.I.	Chalcones	16-25	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	50-55
31446042-0	2019	Antibacterial, antibiofilm and molecular modeling study of some antitumor thiazole based chalcones as a new class of DHFR inhibitors.	Chalcones	89-98	dihydrofolate reductase	Escherichia coli	117-121
31654205-2	2019	Using an iterative electrostatic embedding approach via the Moller-Plesset perturbation (MP2) theory, the chalcone crystals were simulated and the polarization effects on the isolated molecules are investigated.	Chalcones	106-114	tryptase pseudogene 1	Homo sapiens	89-92
30663112-2	2019	Our results indicate that morpholine containing chalcones are highly selective MAO-B inhibitors having reversibility properties.	Chalcones	48-57	monoamine oxidase B	Homo sapiens	79-84
31673309-7	2019	Screening of the whole chalcone library set led to the discovery of over 30 compounds, within six cancerous cell lines, possessing single digit muM IC50 activity as sole agents.	Chalcones	23-31	latexin	Homo sapiens	144-147
30921740-0	2019	Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor kappab activities.	Chalcones	39-48	nitric oxide synthase 2	Homo sapiens	83-122
30921740-5	2019	This review focuses on the anti-inflammatory effects of chalcones, caused by their inhibitory action primarily against the activities and expressions of four key inflammatory mediators viz., cyclooxygenase, prostaglandin E2, inducible NO synthase, and nuclear factor kappaB.	Chalcones	56-65	nitric oxide synthase 2	Homo sapiens	207-246
31026506-5	2019	Naturally occurring chalcones (1,3-diaryl-2-propen-1-ones) have been reported as effective inhibitors of TRPV1.	Chalcones	20-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
31026506-7	2019	By taking advantage of the structural information available, here we discuss pharmacological properties of chalcones and their putative mechanism of binding to TRPV1 channels.	Chalcones	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
30935796-1	2019	As part of a programme to develop anticancer prodrugs which are activated by cytochrome P450 (CYP)1B1, a library of 4,6-diaryl-2-pyridones was synthesised in yields of 6-60% from the corresponding chalcones.	Chalcones	197-206	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	77-101
30482548-5	2019	Furthermore, it was found that these three chalcones induced the mitochondrial apoptotic pathway by regulating Bax and Bcl-2 transcripts and by increasing caspase 3/7 activation.	Chalcones	43-52	BCL2 associated X, apoptosis regulator	Homo sapiens	111-114
30897725-6	2019	Only three chalcones (1c, 2a and 3e) had an inhibitory activity against EGFR-TK with a relative inhibition percentage that was close to the approved drug, erlotinib.	Chalcones	11-20	epidermal growth factor receptor	Homo sapiens	72-76
30897725-8	2019	From the above information, as well as ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties, all three chalcones could serve as lead compounds for the development of EGFR-TK inhibitors.	Chalcones	131-140	epidermal growth factor receptor	Homo sapiens	194-198
30684867-0	2019	On the role of synthesized hydroxylated chalcones as dual functional amyloid-beta aggregation and ferroptosis inhibitors for potential treatment of Alzheimer"s disease.	Chalcones	40-49	amyloid beta precursor protein	Homo sapiens	69-81
30684867-2	2019	Herein, a series of hydroxylated chalcones were designed and synthesized as dual-functional inhibitors to inhibit amyloid-beta peptide (Abeta) aggregation as well as ferroptosis simultaneously.	Chalcones	33-42	amyloid beta precursor protein	Homo sapiens	136-141
30996810-0	2019	Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.	Chalcones	0-9	notch receptor 1	Homo sapiens	46-51
30996810-1	2019	Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors.	Chalcones	58-67	notch receptor 1	Homo sapiens	125-130
30482548-5	2019	Furthermore, it was found that these three chalcones induced the mitochondrial apoptotic pathway by regulating Bax and Bcl-2 transcripts and by increasing caspase 3/7 activation.	Chalcones	43-52	BCL2 apoptosis regulator	Homo sapiens	119-124
30482548-5	2019	Furthermore, it was found that these three chalcones induced the mitochondrial apoptotic pathway by regulating Bax and Bcl-2 transcripts and by increasing caspase 3/7 activation.	Chalcones	43-52	caspase 3	Homo sapiens	155-164
31550216-0	2019	Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer"s Disease.	Chalcones	36-45	monoamine oxidase B	Homo sapiens	100-119
31550216-0	2019	Ethyl Acetohydroxamate Incorporated Chalcones: Unveiling a Novel Class of Chalcones for Multitarget Monoamine Oxidase-B Inhibitors Against Alzheimer"s Disease.	Chalcones	74-83	monoamine oxidase B	Homo sapiens	100-119
31550216-1	2019	BACKGROUND: Chalcones are considered as the selective scaffold for the inhibition of MAO-B.	Chalcones	12-21	monoamine oxidase B	Homo sapiens	85-90
31550216-2	2019	OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD).	Chalcones	37-69	ribosomal protein L22	Homo sapiens	74-77
31187716-5	2019	Hence, the present review highlights the significance of chalcones towardtheir CNS activities (up to 2019), which include anti-depressant activity, anxiolytic activity, activitywith GABA receptors, acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibitions, activityas adenosine receptor antagonists anti-Alzheimer"s agents, beta-amyloid plaques imaging agents,monoamine oxidase inhibition.	Chalcones	57-66	butyrylcholinesterase	Homo sapiens	230-252
31187716-5	2019	Hence, the present review highlights the significance of chalcones towardtheir CNS activities (up to 2019), which include anti-depressant activity, anxiolytic activity, activitywith GABA receptors, acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibitions, activityas adenosine receptor antagonists anti-Alzheimer"s agents, beta-amyloid plaques imaging agents,monoamine oxidase inhibition.	Chalcones	57-66	butyrylcholinesterase	Homo sapiens	254-258
31550216-2	2019	OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD).	Chalcones	37-69	monoamine oxidase A	Homo sapiens	150-175
31550216-2	2019	OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD).	Chalcones	37-69	monoamine oxidase A	Homo sapiens	177-183
31550216-2	2019	OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD).	Chalcones	37-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	188-234
31550216-2	2019	OBJECTIVES: A previously synthesized ethyl acetohydroxamate-chalcones (L1-L22) were studied for their inhibitory activities against human recombinant monoamine oxidase A and B (hMAO-A and hMAO-B, respectively) and acetylcholinesterase (AChE) as multi-target directed ligands for the treatment of Alzheimer"s disease (AD).	Chalcones	37-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	236-240
31550216-8	2019	Among the substitutentin ring Aof ethyl acetohydroxamate-chalcones (L1-L9), F atom at pposition (L3) showed highest inhibitory effect against hMAO-B.	Chalcones	34-66	monoamine oxidase B	Homo sapiens	142-148
31550216-10	2019	Moerover, chalcones L3, L4, L9, L11, and L12 showed potential AChE inhibitory effect with IC50 values 0.67, 0.85, 0.39, 0.30, and 0.45 muM, respectively.	Chalcones	10-19	immunoglobulin kappa variable 1-6	Homo sapiens	32-35
31550216-10	2019	Moerover, chalcones L3, L4, L9, L11, and L12 showed potential AChE inhibitory effect with IC50 values 0.67, 0.85, 0.39, 0.30, and 0.45 muM, respectively.	Chalcones	10-19	LINE1 retrotransposable element 1	Homo sapiens	41-44
31550216-10	2019	Moerover, chalcones L3, L4, L9, L11, and L12 showed potential AChE inhibitory effect with IC50 values 0.67, 0.85, 0.39, 0.30, and 0.45 muM, respectively.	Chalcones	10-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
29934672-1	2018	Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors.	Chalcones	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
30567381-2	2018	Although moderate inhibitory effect was observed for the chalcones against AChE, derivatives 2h, 2j and 2n exhibited significant inhibitory effect against BChE and BACE-1.	Chalcones	57-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79
30567381-2	2018	Although moderate inhibitory effect was observed for the chalcones against AChE, derivatives 2h, 2j and 2n exhibited significant inhibitory effect against BChE and BACE-1.	Chalcones	57-66	butyrylcholinesterase	Homo sapiens	155-159
30567381-2	2018	Although moderate inhibitory effect was observed for the chalcones against AChE, derivatives 2h, 2j and 2n exhibited significant inhibitory effect against BChE and BACE-1.	Chalcones	57-66	beta-secretase 1	Homo sapiens	164-170
30281174-3	2018	We found that licochalcone A, a chalconoid isolated from the root of Glycyrrhiza inflate, was an effective inhibitor for P. acnes-induced NLRP3 inflammasome activation.	Chalcones	32-42	NLR family pyrin domain containing 3	Homo sapiens	138-143
29934672-1	2018	Chalcones containing tertiary amine side-chains have potent activity as acetylcholinesterase (AChE) inhibitors.	Chalcones	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98
29980517-0	2018	The Ashitaba (Angelica keiskei) Chalcones 4-hydroxyderricin and Xanthoangelol Suppress Melanomagenesis By Targeting BRAF and PI3K.	Chalcones	32-41	Braf transforming gene	Mus musculus	116-120
30237123-0	2018	Piperidinyl-embeded chalcones possessing anti PI3Kdelta inhibitory properties exhibit anti-atopic properties in preclinical models.	Chalcones	20-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	46-55
30235848-15	2018	These effects probably result from the induced increase of p53 protein expression by the two chalcones.	Chalcones	93-102	tumor protein p53	Homo sapiens	59-62
30235848-16	2018	In conclusion, chalcones D14 and D15 have potential anti-metastatic activity mediated by p53 that can be exploited for OS treatment.	Chalcones	15-24	tumor protein p53	Homo sapiens	89-92
30037040-0	2018	The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones.	Chalcones	59-68	kelch like ECH associated protein 1	Homo sapiens	4-9
30189396-1	2018	Several flavonoids and their biosynthetic precursor chalcones were designed and synthesized to improve the biological effects of the lead compound 2"-hydroxyflavonone against androgen receptor (AR)-dependent transcriptional stimulation.	Chalcones	52-61	androgen receptor	Homo sapiens	175-192
30189396-1	2018	Several flavonoids and their biosynthetic precursor chalcones were designed and synthesized to improve the biological effects of the lead compound 2"-hydroxyflavonone against androgen receptor (AR)-dependent transcriptional stimulation.	Chalcones	52-61	androgen receptor	Homo sapiens	194-196
30189396-2	2018	Newly synthesized chalcones 19 and 26 suppressed AR-dependent transcription as well as DHT-dependent growth stimulation at a low micromolar level.	Chalcones	18-27	androgen receptor	Homo sapiens	49-51
30104527-0	2018	Chalcones Repressed the AURKA and MDR Proteins Involved in Metastasis and Multiple Drug Resistance in Breast Cancer Cell Lines.	Chalcones	0-9	aurora kinase A	Homo sapiens	24-29
30011209-4	2018	We also investigated osteogenic differentiation of C2C12 cells by ALP staining, the early marker for osteogenesis, which demonstrated that the chalcones could not only induce activity of BMP-2 but also inhibit the activity of noggin, a BMP antagonist.	Chalcones	143-152	alopecia, recessive	Mus musculus	66-69
30011209-4	2018	We also investigated osteogenic differentiation of C2C12 cells by ALP staining, the early marker for osteogenesis, which demonstrated that the chalcones could not only induce activity of BMP-2 but also inhibit the activity of noggin, a BMP antagonist.	Chalcones	143-152	bone morphogenetic protein 2	Mus musculus	187-192
30011209-4	2018	We also investigated osteogenic differentiation of C2C12 cells by ALP staining, the early marker for osteogenesis, which demonstrated that the chalcones could not only induce activity of BMP-2 but also inhibit the activity of noggin, a BMP antagonist.	Chalcones	143-152	noggin	Mus musculus	226-232
30011209-4	2018	We also investigated osteogenic differentiation of C2C12 cells by ALP staining, the early marker for osteogenesis, which demonstrated that the chalcones could not only induce activity of BMP-2 but also inhibit the activity of noggin, a BMP antagonist.	Chalcones	143-152	bone morphogenetic protein 2	Mus musculus	187-190
30128080-0	2018	Tariquidar-Related Chalcones and Ketones as ABCG2 Modulators.	Chalcones	19-28	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-49
30037040-3	2018	Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2.	Chalcones	0-9	kelch like ECH associated protein 1	Homo sapiens	190-195
30037040-3	2018	Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2.	Chalcones	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	252-256
30037040-7	2018	In this review we summarize the current progress in the study of Keap1/Nrf2-ARE pathway activation by natural and synthetic chalcones and their potential pharmacological applications.	Chalcones	124-133	kelch like ECH associated protein 1	Homo sapiens	65-70
30037040-7	2018	In this review we summarize the current progress in the study of Keap1/Nrf2-ARE pathway activation by natural and synthetic chalcones and their potential pharmacological applications.	Chalcones	124-133	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
30037040-8	2018	Among the pharmacological activities highlighted, anti-inflammatory activity was more evident than others, suggesting a multi-target Michael acceptor mechanism for the chalcones involving key regulators of the Nrf2 and nuclear factor- kappaB (NF-kappaB) pathways.	Chalcones	168-177	NFE2 like bZIP transcription factor 2	Homo sapiens	210-214
30037040-8	2018	Among the pharmacological activities highlighted, anti-inflammatory activity was more evident than others, suggesting a multi-target Michael acceptor mechanism for the chalcones involving key regulators of the Nrf2 and nuclear factor- kappaB (NF-kappaB) pathways.	Chalcones	168-177	nuclear factor kappa B subunit 1	Homo sapiens	235-241
30037040-8	2018	Among the pharmacological activities highlighted, anti-inflammatory activity was more evident than others, suggesting a multi-target Michael acceptor mechanism for the chalcones involving key regulators of the Nrf2 and nuclear factor- kappaB (NF-kappaB) pathways.	Chalcones	168-177	nuclear factor kappa B subunit 1	Homo sapiens	243-252
30104527-3	2018	Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner.	Chalcones	79-88	aurora kinase A	Homo sapiens	102-107
30037040-0	2018	The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones.	Chalcones	59-68	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
31458944-0	2018	Synthesis of 1,2,4-Trisubstituted-(1H)-imidazoles through Cu(OTf)2-/I2-Catalyzed C-C Bond Cleavage of Chalcones and Benzylamines.	Chalcones	102-111	POU class 2 homeobox 2	Homo sapiens	58-66
30037040-3	2018	Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2.	Chalcones	0-9	kelch like ECH associated protein 1	Homo sapiens	29-64
31458944-1	2018	1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu(OTf)2- and I2-catalyzed unusual C-C bond cleavage of chalcones and benzylamines.	Chalcones	122-131	POU class 2 homeobox 2	Homo sapiens	66-74
30037040-3	2018	Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2.	Chalcones	0-9	kelch like ECH associated protein 1	Homo sapiens	66-71
30037040-3	2018	Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2.	Chalcones	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	73-116
30037040-3	2018	Chalcones could activate the Kelch-like ECH-associated protein 1 (Keap1)/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway through a Michael addition reaction with the cysteines of Keap1, which acts as a redox sensor and negative regulator of Nrf2.	Chalcones	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
30221226-0	2018	Chalcones and Five-Membered Heterocyclic Isosteres Bind to Alpha Synuclein Fibrils in Vitro.	Chalcones	0-9	synuclein alpha	Homo sapiens	59-74
30237673-0	2018	Binding property of HIV p24 and Reverse transcriptase by chalcones from Pongamia pinnata seeds.	Chalcones	57-66	transmembrane p24 trafficking protein 2	Homo sapiens	24-27
29473699-0	2018	Evaluation of chalcones as inhibitors of glutathione S-transferase.	Chalcones	14-23	glutathione S-transferase kappa 1	Homo sapiens	41-66
29630947-5	2018	Mechanistically, inhibition of cancer cell invasion and inflammation by the compounds were mediated through suppression of the nuclear factor-kappaB (NF-kappaB) signaling pathway, which corroborated with the reported mechanism of action of chalcones.	Chalcones	240-249	nuclear factor kappa B subunit 1	Homo sapiens	127-148
29630947-5	2018	Mechanistically, inhibition of cancer cell invasion and inflammation by the compounds were mediated through suppression of the nuclear factor-kappaB (NF-kappaB) signaling pathway, which corroborated with the reported mechanism of action of chalcones.	Chalcones	240-249	nuclear factor kappa B subunit 1	Homo sapiens	150-159
29175112-4	2018	Chalcones improve adipocytes function and adiponectin secretion.	Chalcones	0-9	adiponectin, C1Q and collagen domain containing	Homo sapiens	42-53
29518899-4	2018	Therefore, the nitrogen atom in this series of azachalcones must play a more crucial role than the corresponding C-2 hydroxyl group of chalcones in biological activity.	Chalcones	50-59	complement component 2 (within H-2S)	Mus musculus	113-116
30108910-7	2018	All the pyrone-based chalcones showed no recognizable level of cytotoxicity against normal human kidney cell line (HEK-293) up to 80 muM concentration and 11 exhibited an IC50 <= 100 muM (highest tested concentration).	Chalcones	21-30	latexin	Homo sapiens	186-189
28971779-6	2018	OBJECTIVE: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities.	Chalcones	160-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	88-93
28971779-6	2018	OBJECTIVE: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities.	Chalcones	160-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	236-241
28971779-6	2018	OBJECTIVE: Owing to high anticancer potential of ferrocene derivatives and considerable COX-2 inhibitory and cytotoxicity effects of our previously synthesized chalcones, we decided to incorporate the ferrocenyl moiety into appropriate COX-2 inhibitor chalcone based scaffold, to evaluate COX-2 inhibitory activity as well as anticancer activities.	Chalcones	160-169	prostaglandin-endoperoxide synthase 2	Homo sapiens	236-241
29332599-0	2018	The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells.	Chalcones	17-26	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	77-81
29332599-9	2018	CONCLUSION: Chalcones show promise as anticancer agents with evidence suggesting that CYP1 activation of these compounds may be involved.	Chalcones	12-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	86-90
29138024-3	2017	Herein, thirteen pyridine-4-yl series of chalcones were synthesized and screened for inhibition of CYP1 isoforms 1A1, 1B1 and 1A2 in Sacchrosomes  and live human HEK293 cells.	Chalcones	41-50	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	99-103
29138024-4	2017	The structure-activity relationship analysis indicated that chalcones bearing tri-alkoxy groups (8a and 8k) on non-heterocyclic ring displayed selective inhibition of CYP1A1 enzyme, with IC50 values of 58 and 65 nM, respectively.	Chalcones	60-69	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	167-173
29697034-10	2018	The chalcones are less potent as inhibitors of MAO with the most potent inhibitor possessing a Ki of 4.6 microM for the in vitro inhibition of human MAO-B.	Chalcones	4-13	monoamine oxidase B	Homo sapiens	149-154
29280968-6	2017	Furthermore, a molecular docking study was carried out to explain the observed effects and the binding modes of these chalcones with the EGFR TK and tubulin targets.	Chalcones	118-127	epidermal growth factor receptor	Homo sapiens	137-141
28743509-8	2017	Such activities were absent in 3-(4-methoxyphenyl)propiophenone (SSE14106H2) demonstrating the importance of conjugated ketone for antiproliferative and p53 stabilizing activity of the chalcones.	Chalcones	185-194	tumor protein p53	Homo sapiens	153-156
28577983-2	2017	Based on our previous report, the methoxy-substituted with fluorine containing chalcones are promising reversible MAO-B inhibitors, while in the present study, a series of methoxylated chalcones (C1-C9) bearing substitution on the para position of ring B was synthesized and evaluated for their human monoamine oxidase inhibitory activity.	Chalcones	79-88	monoamine oxidase B	Homo sapiens	114-119
28577983-2	2017	Based on our previous report, the methoxy-substituted with fluorine containing chalcones are promising reversible MAO-B inhibitors, while in the present study, a series of methoxylated chalcones (C1-C9) bearing substitution on the para position of ring B was synthesized and evaluated for their human monoamine oxidase inhibitory activity.	Chalcones	185-194	monoamine oxidase B	Homo sapiens	114-119
28835349-5	2017	The results indicated a number of chalcones were potent Nrf2 activators, including 11 (licochalcone A, 4.07-fold), 12 (licochalcone B, 5.17-fold), and 19 (echinatin, 4.09-fold).	Chalcones	34-43	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
29032339-1	2017	Major limitations of chalcones as clinical anticancer agents are water insolubility and poor bioavailability, which may be improved by a classic phosphate prodrug strategy that targets non-specific alkaline phosphatase (ALP) for releasing the parent drug in vivo.	Chalcones	21-30	alkaline phosphatase, placental	Homo sapiens	198-218
29032339-1	2017	Major limitations of chalcones as clinical anticancer agents are water insolubility and poor bioavailability, which may be improved by a classic phosphate prodrug strategy that targets non-specific alkaline phosphatase (ALP) for releasing the parent drug in vivo.	Chalcones	21-30	alkaline phosphatase, placental	Homo sapiens	220-223
28743509-10	2017	These chalcones can, therefore, act as fragment leads for further structure optimization to obtain more potent p53 stabilizing agents with enhanced anti-proliferative activities.	Chalcones	6-15	tumor protein p53	Homo sapiens	111-114
28711350-2	2017	In this letter, we report synthesis of twenty-three pyrrole based heterocyclic chalcones which were screened for inhibition of CYP1 isoforms.	Chalcones	79-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	127-131
28687725-2	2017	In the present study, we intended to explore the cholinesterase inhibitory activity of some novel synthesized chalcones, together with their effect on beta-amyloid anti-aggregation.	Chalcones	110-119	butyrylcholinesterase	Homo sapiens	49-63
28528971-1	2017	Chalcones, the biosynthetic precursors of flavonoids and isoflavonoids abundant in edible plants, possess a number of pharmacological properties, and there is growing evidence that chalcone derivatives inhibit TNF-alpha mediated insulin resistance.	Chalcones	0-9	tumor necrosis factor	Mus musculus	210-219
28235703-0	2017	Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.	Chalcones	40-49	nuclear receptor subfamily 1, group H, member 4	Mus musculus	99-102
28222316-0	2017	Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.	Chalcones	80-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	40-46
28222316-0	2017	Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines.	Chalcones	80-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	126-132
28222316-1	2017	The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones.	Chalcones	109-118	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	66-72
28442256-5	2017	We suggest that the chalcones used in this study inhibit mammalian target of rapamycin (mTOR) pathway by ablating phosphorylation of ribosomal protein 6 (rps6), and also the kinase necessary for phosphorylating rps6 in Huh7.5 cells (pS6K1).	Chalcones	20-29	mechanistic target of rapamycin kinase	Homo sapiens	57-86
28442256-5	2017	We suggest that the chalcones used in this study inhibit mammalian target of rapamycin (mTOR) pathway by ablating phosphorylation of ribosomal protein 6 (rps6), and also the kinase necessary for phosphorylating rps6 in Huh7.5 cells (pS6K1).	Chalcones	20-29	mechanistic target of rapamycin kinase	Homo sapiens	88-92
28442256-5	2017	We suggest that the chalcones used in this study inhibit mammalian target of rapamycin (mTOR) pathway by ablating phosphorylation of ribosomal protein 6 (rps6), and also the kinase necessary for phosphorylating rps6 in Huh7.5 cells (pS6K1).	Chalcones	20-29	ribosomal protein S6	Homo sapiens	154-158
28442256-5	2017	We suggest that the chalcones used in this study inhibit mammalian target of rapamycin (mTOR) pathway by ablating phosphorylation of ribosomal protein 6 (rps6), and also the kinase necessary for phosphorylating rps6 in Huh7.5 cells (pS6K1).	Chalcones	20-29	ribosomal protein S6	Homo sapiens	211-215
28442256-5	2017	We suggest that the chalcones used in this study inhibit mammalian target of rapamycin (mTOR) pathway by ablating phosphorylation of ribosomal protein 6 (rps6), and also the kinase necessary for phosphorylating rps6 in Huh7.5 cells (pS6K1).	Chalcones	20-29	MIR7-3 host gene	Homo sapiens	219-223
28242551-0	2017	Analogues of xanthones--Chalcones and bis-chalcones as alpha-glucosidase inhibitors and anti-diabetes candidates.	Chalcones	24-33	sucrase-isomaltase	Homo sapiens	55-72
28222316-1	2017	The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones.	Chalcones	109-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	77-83
28235703-2	2017	Starting from two previously identified chalcone-based FXR antagonists, we tried to increase the activity through the design and synthesis of a library containing chalcones, flavones and chromenes, based on substitution manipulation and conformation (ring closure) restriction strategy.	Chalcones	163-172	nuclear receptor subfamily 1, group H, member 4	Mus musculus	55-58
28235703-3	2017	Many chalcones and four chromenes were identified as microM potent FXR antagonists, among which chromene 11c significantly decreased the plasma and hepatic triglyceride level in KKay mice.	Chalcones	5-14	nuclear receptor subfamily 1, group H, member 4	Mus musculus	67-70
28271110-1	2017	The catalytic asymmetric bromoamination of chalcones with N-bromosuccinimide as both bromine and amide source was realized by using a chiral N,N"-dioxide-Sc(NTf2)3 complex as an efficient catalyst.	Chalcones	43-52	nuclear transport factor 2	Homo sapiens	157-161
28177228-2	2017	The 4,6-diamino-1,2-dihydro-1,3,5-triazine scaffold is well-established as a useful scaffold for DHFR inhibition, while chalcones have been reported to be inhibitors of TrxR.	Chalcones	120-129	peroxiredoxin 5	Homo sapiens	169-173
28392527-0	2017	Interactions of Three Chalcones with Human Serum Albumin Revealed by Spectroscopic Techniques.	Chalcones	22-31	albumin	Homo sapiens	49-56
26815590-12	2017	The kinetics of the examined chalcones are indicative of a distribution to the tissue compartment with the predominance of a rate constant from central to peripheral compartments (k12) over the rate constant from peripheral to central compartments (k21).	Chalcones	29-38	keratin 12	Rattus norvegicus	180-183
28392527-4	2017	The binding affinities of three chalcones with HSA at pH 7.4 were ranked in the order (the binding constants in the range 0.28 - 2.39 x 105 L mol-1), 2",4",4-triHC > 2",4"-diHC > 4-HC, indicating that the three chalcones displayed tight affinities for HSA and the hydroxyl group in chalcones played a key role in their binding affinities with HSA.	Chalcones	32-41	albumin	Homo sapiens	258-261
28392527-4	2017	The binding affinities of three chalcones with HSA at pH 7.4 were ranked in the order (the binding constants in the range 0.28 - 2.39 x 105 L mol-1), 2",4",4-triHC > 2",4"-diHC > 4-HC, indicating that the three chalcones displayed tight affinities for HSA and the hydroxyl group in chalcones played a key role in their binding affinities with HSA.	Chalcones	32-41	albumin	Homo sapiens	47-50
28392527-4	2017	The binding affinities of three chalcones with HSA at pH 7.4 were ranked in the order (the binding constants in the range 0.28 - 2.39 x 105 L mol-1), 2",4",4-triHC > 2",4"-diHC > 4-HC, indicating that the three chalcones displayed tight affinities for HSA and the hydroxyl group in chalcones played a key role in their binding affinities with HSA.	Chalcones	217-226	albumin	Homo sapiens	47-50
28392527-4	2017	The binding affinities of three chalcones with HSA at pH 7.4 were ranked in the order (the binding constants in the range 0.28 - 2.39 x 105 L mol-1), 2",4",4-triHC > 2",4"-diHC > 4-HC, indicating that the three chalcones displayed tight affinities for HSA and the hydroxyl group in chalcones played a key role in their binding affinities with HSA.	Chalcones	217-226	albumin	Homo sapiens	47-50
28392527-4	2017	The binding affinities of three chalcones with HSA at pH 7.4 were ranked in the order (the binding constants in the range 0.28 - 2.39 x 105 L mol-1), 2",4",4-triHC > 2",4"-diHC > 4-HC, indicating that the three chalcones displayed tight affinities for HSA and the hydroxyl group in chalcones played a key role in their binding affinities with HSA.	Chalcones	32-41	albumin	Homo sapiens	258-261
28392527-5	2017	The results of the UV absorption and the fluorescence enhancement elucidated that the chalcones may lead to micro-environmental and conformational changes of HSA.	Chalcones	86-95	albumin	Homo sapiens	158-161
28245770-4	2017	Chromones are structurally related to a series of coumarins and chalcones, which are well-known inhibitors of MAO-B.	Chalcones	64-73	monoamine oxidase B	Homo sapiens	110-115
28392527-6	2017	The binding site of the chalcone 2",4",4-triHC on the HSA was explored by the spectroscopic properties of the 2",4",4-triHC-HSA complex at pH 7.4 and 3.5, and the results demonstrated that 2",4",4-triHC bound within the hydrophobic pockets of subdomain IIA of HSA, namely site I, and the electrostatic force and ionic interactions played a crucial role in the binding interaction between chalcones and protein.	Chalcones	388-397	albumin	Homo sapiens	54-57
28392527-6	2017	The binding site of the chalcone 2",4",4-triHC on the HSA was explored by the spectroscopic properties of the 2",4",4-triHC-HSA complex at pH 7.4 and 3.5, and the results demonstrated that 2",4",4-triHC bound within the hydrophobic pockets of subdomain IIA of HSA, namely site I, and the electrostatic force and ionic interactions played a crucial role in the binding interaction between chalcones and protein.	Chalcones	388-397	albumin	Homo sapiens	124-127
28392527-6	2017	The binding site of the chalcone 2",4",4-triHC on the HSA was explored by the spectroscopic properties of the 2",4",4-triHC-HSA complex at pH 7.4 and 3.5, and the results demonstrated that 2",4",4-triHC bound within the hydrophobic pockets of subdomain IIA of HSA, namely site I, and the electrostatic force and ionic interactions played a crucial role in the binding interaction between chalcones and protein.	Chalcones	388-397	albumin	Homo sapiens	124-127
27903423-7	2017	In western blot assay, the two chalcones reduced the expression of cell death-related proteins such as Bcl-2 and cyclin D1 and promoted the cleavage of PARP.	Chalcones	31-40	B cell leukemia/lymphoma 2	Mus musculus	103-108
27903423-7	2017	In western blot assay, the two chalcones reduced the expression of cell death-related proteins such as Bcl-2 and cyclin D1 and promoted the cleavage of PARP.	Chalcones	31-40	cyclin D1	Mus musculus	113-122
27903423-7	2017	In western blot assay, the two chalcones reduced the expression of cell death-related proteins such as Bcl-2 and cyclin D1 and promoted the cleavage of PARP.	Chalcones	31-40	poly (ADP-ribose) polymerase family, member 1	Mus musculus	152-156
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Chalcones	79-88	proliferating cell nuclear antigen	Homo sapiens	101-107
27810244-0	2016	Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation.	Chalcones	16-25	KRAS proto-oncogene, GTPase	Homo sapiens	100-104
27341558-8	2016	Together with the previous finding that alpha-Br-TMC and alpha-CF3-TMC inhibit the response to inflammation by inducing Nrf2 and blocking NF-kappaB activities, our data suggest that synthetic chalcones might be useful as anti-inflammatory, anti-cancer and immunomodulatory agents in the treatment of human diseases.	Chalcones	192-201	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
27727127-3	2016	The pyrazolines inhibited ATP-binding cassette efflux transporters of types P-gp and BCRP while the chalcones inhibited selectively BCRP.	Chalcones	100-109	BCR pseudogene 1	Homo sapiens	132-136
28545385-0	2017	Effect on Acetylcholinesterase and Anti-oxidant Activity of Synthetic Chalcones having a Good Predicted Pharmacokinetic Profile.	Chalcones	70-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-30
28545385-2	2017	In this work, we investigated the effect of twenty-two synthesized chalcones on AChE activity.	Chalcones	67-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	80-84
28545385-3	2017	OBJECTIVE: This work is aimed to synthesize and evaluate the effect of chalcones on the AChE activity, as well as anti-oxidant activity and predict their pharmacokinetic profile.	Chalcones	71-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	88-92
28545385-4	2017	METHOD: Chalcones were synthesized through a Claisen-Schmidt condensation and their inhibitory effect on the AChE was evaluated by the Elmann"s colorimetric method.	Chalcones	8-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	109-113
27902880-1	2016	Numerous studies have shown that chalcones are promising scaffolds for the development of new monoamine oxidase-B (MAO-B) inhibitors.	Chalcones	33-42	monoamine oxidase B	Homo sapiens	94-113
27902880-1	2016	Numerous studies have shown that chalcones are promising scaffolds for the development of new monoamine oxidase-B (MAO-B) inhibitors.	Chalcones	33-42	monoamine oxidase B	Homo sapiens	115-120
27810244-2	2016	Treatment of human lung cancer cell line harboring KRAS mutation (A549) with the chalcones induced dose-dependent apoptosis.	Chalcones	81-90	KRAS proto-oncogene, GTPase	Homo sapiens	51-55
27735138-1	2016	Chalcones are easily synthesized natural precursors of secondary plant metabolites, and their derivatives show various biological activities including inhibition of ABC transporters.	Chalcones	0-9	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	165-168
27517610-4	2016	With this in mind, we studied the binding modes of 37 flavonoids (flavones and chalcones) inside the cyclin-dependent PK CDK1 using docking experiments.	Chalcones	79-88	cyclin dependent kinase 1	Homo sapiens	121-125
27402375-2	2016	In our previous study, we have shown that a series of methoxylated chalcones with F functional group exhibited high binding affinity toward human monoamine oxidase-B (hMAO-B).	Chalcones	67-76	monoamine oxidase B	Homo sapiens	146-165
27402375-2	2016	In our previous study, we have shown that a series of methoxylated chalcones with F functional group exhibited high binding affinity toward human monoamine oxidase-B (hMAO-B).	Chalcones	67-76	monoamine oxidase B	Homo sapiens	167-173
27100033-1	2016	During the last decade it has been found that chalcones and quinazolines are promising inhibitors of ABCG2.	Chalcones	46-55	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	101-106
27044026-2	2016	The inducible enzyme heme oxygenase-1 (HO-1) protects cells against inflammation and can be induced by electrophilic compounds like the chalcones (1,3-diphenylprop-2-enones) from the class of alpha,beta-unsaturated carbonyl compounds.	Chalcones	136-145	heme oxygenase 1	Homo sapiens	39-43
26994844-3	2016	In order to evaluate whether simultaneous inhibition of DHFR and TrxR by dihydrotriazines (DHFR-targeting) and chalcones (TrxR-targeting) may be beneficial, breast MCF-7 and colorectal HCT116 carcinoma cells were treated with combinations of selected dihydrotriazines and chalcones at a 1:1 M ratio.	Chalcones	111-120	peroxiredoxin 5	Homo sapiens	122-126
26660296-0	2016	Design and Discovery of Some Novel Chalcones as Antioxidant and Anti-Inflammatory Agents via Attenuating NF-kappaB.	Chalcones	35-44	nuclear factor kappa B subunit 1	Homo sapiens	105-114
26974383-0	2016	Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors.	Chalcones	30-39	monoamine oxidase B	Homo sapiens	60-79
26974383-1	2016	A novel series of substituted chalcones were designed and synthesized to be evaluated as selective human MAO-B inhibitors.	Chalcones	30-39	monoamine oxidase B	Homo sapiens	105-110
26907262-7	2016	Caspase-8 was not activated, but caspase-3 and -9 were both activated by chalcones in HepG2 cells.	Chalcones	73-82	caspase 3	Homo sapiens	33-49
26762836-6	2016	Since it has been proposed previously that XO inhibition and radical scavenging could be useful properties for reduction of ROS-levels in tissue, we determined the chalcones" effects to rescue neurons subjected to ROS-induced stress created by the addition of beta-amyloid peptide.	Chalcones	164-173	amyloid beta precursor protein	Homo sapiens	260-280
27071783-4	2016	Chalcones can be considered as novel candidates for the development of antihyperalgesic preparations based on TRPA1 desensitization.	Chalcones	0-9	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	110-115
26429556-5	2016	Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.	Chalcones	49-58	monoamine oxidase A	Homo sapiens	70-75
26429556-3	2016	The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.	Chalcones	100-109	monoamine oxidase A	Homo sapiens	118-123
26429556-4	2016	CONCLUSION: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A.	Chalcones	66-75	monoamine oxidase B	Homo sapiens	116-121
26649241-0	2015	Inhibition of plasminogen activator inhibitor-1 release from human endothelial cells by Angelica keiskei Koidzumi (Ashitaba) chalcones is structure-dependent.	Chalcones	125-134	serpin family E member 1	Homo sapiens	14-47
26475964-9	2015	Furthermore, a correlation between the distinct cytotoxicity of chalcones 1 and 2 and their ability to disrupt the p53-MDM2 interaction was established.	Chalcones	64-73	tumor protein p53	Homo sapiens	115-118
26475964-9	2015	Furthermore, a correlation between the distinct cytotoxicity of chalcones 1 and 2 and their ability to disrupt the p53-MDM2 interaction was established.	Chalcones	64-73	MDM2 proto-oncogene	Homo sapiens	119-123
26475964-10	2015	SIGNIFICANCE: This work shows that prenylation is a determinant factor for the enhancement of chalcones tumour cytotoxicity by improving their ability to disrupt the p53-MDM2 interaction.	Chalcones	94-103	tumor protein p53	Homo sapiens	166-169
26475964-10	2015	SIGNIFICANCE: This work shows that prenylation is a determinant factor for the enhancement of chalcones tumour cytotoxicity by improving their ability to disrupt the p53-MDM2 interaction.	Chalcones	94-103	MDM2 proto-oncogene	Homo sapiens	170-174
26432037-9	2015	We conclude that high potency chalcones such as 4h represent suitable leads for the development of MAO-B inhibitors for the treatment of Parkinson"s disease and possibly other neurodegenerative disorders.	Chalcones	30-39	monoamine oxidase B	Homo sapiens	99-104
26351039-0	2015	Synthesis, alpha-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones.	Chalcones	126-135	sucrase-isomaltase	Homo sapiens	11-28
26248214-0	2015	Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones.	Chalcones	123-132	butyrylcholinesterase	Homo sapiens	85-99
26248214-3	2015	This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Abeta species, and inhibit AChE/BChE activity.	Chalcones	84-93	amyloid beta precursor protein	Homo sapiens	194-199
26248214-3	2015	This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Abeta species, and inhibit AChE/BChE activity.	Chalcones	84-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	221-225
26248214-3	2015	This work presents the design, synthesis, and biochemical evaluation of a series of chalcones, and assesses the relationship between their structures and their ability to bind metal ions and/or Abeta species, and inhibit AChE/BChE activity.	Chalcones	84-93	butyrylcholinesterase	Homo sapiens	226-230
26248214-4	2015	Several chalcones were found to exhibit potent disaggregation of pre-formed N-biotinyl Abeta1-42 (bioAbeta42) aggregates in vitro in the absence and presence of Cu(2+)/Zn(2+), while others were effective at inhibiting the action of AChE.	Chalcones	8-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	232-236
26193682-0	2015	Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L. Cathepsin B [EC 3.4.22.1], cathepsin H [EC 3.4.22.16] and cathepsin L [EC 3.4.22.15] are the most versatile lysosomal cysteine proteases and are responsible for intracellular protein degradation.	Chalcones	0-9	cathepsin B	Homo sapiens	82-93
26141763-11	2015	Furthermore, xanthoangelol (5-50 muM) inhibited the phosphorylation of Stat 3 without affecting the expression of the Stat 3 protein in the differentiation process of M2 macrophages, which indicated that these chalcones inhibited the differentiation of M2 macrophages.	Chalcones	210-219	signal transducer and activator of transcription 3	Mus musculus	71-77
25688010-1	2015	Using whole-cell patch-clamp technique, we investigated influence of selected compounds from groups of prenylated chalcones and flavonoids: xanthohumol and isoxanthohumol on the activity of Kv1.3 channels in human leukemic Jurkat T cells.	Chalcones	114-123	potassium voltage-gated channel subfamily A member 3	Homo sapiens	190-195
25688010-9	2015	These results may confirm our earlier hypothesis that the presence of a prenyl group in a molecule is a factor that facilitates the inhibition of Kv1.3 channels by compounds from the groups of flavonoids and chalcones.	Chalcones	208-217	potassium voltage-gated channel subfamily A member 3	Homo sapiens	146-151
25466202-2	2015	Emerging evidence indicates that various natural and synthetic chalcones exhibit antimetastatic activity through the inhibition of nuclear factor-kappaB (NF-kappaB), although the precise mechanism by which this occurs is currently unclear.	Chalcones	63-72	nuclear factor kappa B subunit 1	Homo sapiens	131-152
25775405-5	2015	Both chalcones are able to affect the cell distribution of beta-catenin, and inhibit Wnt-specific reporter activity in HCT116 cells and in Xenopus embryos.	Chalcones	5-14	catenin beta 1	Homo sapiens	59-71
25775405-8	2015	Taken together, our results strongly support these chalcones as novel negative modulators of the Wnt/beta-catenin pathway and colon cancer cell growth in vitro.	Chalcones	51-60	catenin beta 1 L homeolog	Xenopus laevis	101-113
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	peroxisome proliferator activated receptor gamma	Homo sapiens	143-153
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	dipeptidyl peptidase 4	Homo sapiens	155-160
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	sucrase-isomaltase	Homo sapiens	162-179
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	181-186
25638569-3	2015	Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-gamma, DPP-4, alpha-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.	Chalcones	37-46	aldo-keto reductase family 1 member B	Homo sapiens	188-204
25466202-2	2015	Emerging evidence indicates that various natural and synthetic chalcones exhibit antimetastatic activity through the inhibition of nuclear factor-kappaB (NF-kappaB), although the precise mechanism by which this occurs is currently unclear.	Chalcones	63-72	nuclear factor kappa B subunit 1	Homo sapiens	154-163
24845100-0	2014	The chalcones cardamonin and flavokawain B inhibit the differentiation of preadipocytes to adipocytes by activating ERK.	Chalcones	4-13	mitogen-activated protein kinase 1	Mus musculus	116-119
24913985-0	2014	SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.	Chalcones	42-51	cathepsin B	Homo sapiens	127-138
24913985-0	2014	SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H.	Chalcones	42-51	cathepsin H	Homo sapiens	143-154
24583196-7	2014	Chalcones R7 and R13 induced an increase of pro-apoptotic proteins Bax, Bid and Bak (only chalcone R13), as well as a decrease in anti-apoptotic Bcl-2 expression.	Chalcones	0-9	BCL2-associated X protein	Mus musculus	67-70
24583196-7	2014	Chalcones R7 and R13 induced an increase of pro-apoptotic proteins Bax, Bid and Bak (only chalcone R13), as well as a decrease in anti-apoptotic Bcl-2 expression.	Chalcones	0-9	BH3 interacting domain death agonist	Mus musculus	72-75
24583196-7	2014	Chalcones R7 and R13 induced an increase of pro-apoptotic proteins Bax, Bid and Bak (only chalcone R13), as well as a decrease in anti-apoptotic Bcl-2 expression.	Chalcones	0-9	BCL2-antagonist/killer 1	Mus musculus	80-83
24583196-7	2014	Chalcones R7 and R13 induced an increase of pro-apoptotic proteins Bax, Bid and Bak (only chalcone R13), as well as a decrease in anti-apoptotic Bcl-2 expression.	Chalcones	0-9	B cell leukemia/lymphoma 2	Mus musculus	145-150
24583196-8	2014	These chalcones also induced an increase in Fas and a decrease in p21 and p53 expression.	Chalcones	6-15	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	66-69
24583196-8	2014	These chalcones also induced an increase in Fas and a decrease in p21 and p53 expression.	Chalcones	6-15	transformation related protein 53, pseudogene	Mus musculus	74-77
24583196-10	2014	All compounds induced an increase in cell calcium concentration and an increase in CHOP expression, which together with an increase in caspase-12 activity, suggest that chalcones could induce an endoplasmic reticulum (ER) stress.	Chalcones	169-178	DNA-damage inducible transcript 3	Mus musculus	83-87
24583196-10	2014	All compounds induced an increase in cell calcium concentration and an increase in CHOP expression, which together with an increase in caspase-12 activity, suggest that chalcones could induce an endoplasmic reticulum (ER) stress.	Chalcones	169-178	caspase 12	Mus musculus	135-145
25442306-2	2014	Among the synthesized chalcones, compound 6n was found to be the most potent and selective against A549 lung cancer cell line (IC50 = 0.8 muM).	Chalcones	22-31	latexin	Homo sapiens	138-141
24845100-8	2014	CONCLUSIONS: These results indicate that ERK activation and consequent downregulation of adipocyte-specific transcription factors are involved in the inhibitory effects of the chalcones cardamonin and flavokawain B on adipocyte differentiation.	Chalcones	176-185	mitogen-activated protein kinase 1	Mus musculus	41-44
25276196-2	2014	In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay.	Chalcones	47-56	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	123-128
25276196-2	2014	In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay.	Chalcones	47-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	136-141
25276196-2	2014	In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay.	Chalcones	47-56	chaperonin containing TCP1 subunit 4	Homo sapiens	283-299
25276196-2	2014	In this study, a group of recently synthesized chalcones, with the structure of 1,3-diarylprop-2-en-1-one having different COX-1 and/or COX-2 selectivities have been examined on human hepatocarcinoma (HepG2), lung carcinoma (A549), and breast adenocarcinoma (MCF-7) cell line, using Sulforhodamine B (SRB) assay.	Chalcones	47-56	chaperonin containing TCP1 subunit 4	Homo sapiens	301-304
24722377-0	2014	Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells.	Chalcones	0-9	serine/threonine kinase 11	Homo sapiens	67-71
24747187-0	2014	Synthesis, characterization, theoretical, anti-bacterial and molecular docking studies of quinoline based chalcones as a DNA gyrase inhibitor.	Chalcones	106-115	DNA topoisomerase II alpha	Homo sapiens	121-131
24722377-0	2014	Chalcones suppress fatty acid-induced lipid accumulation through a LKB1/AMPK signaling pathway in HepG2 cells.	Chalcones	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	72-76
24722377-7	2014	We also found that these chalcones increased the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which is involved in FA oxidation.	Chalcones	25-34	peroxisome proliferator activated receptor alpha	Homo sapiens	63-111
24722377-7	2014	We also found that these chalcones increased the expression of peroxisome proliferator-activated receptor alpha (PPARalpha), which is involved in FA oxidation.	Chalcones	25-34	peroxisome proliferator activated receptor alpha	Homo sapiens	113-122
24722377-8	2014	Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARalpha.	Chalcones	16-25	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	55-83
24722377-8	2014	Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARalpha.	Chalcones	16-25	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	85-89
24722377-8	2014	Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARalpha.	Chalcones	16-25	serine/threonine kinase 11	Homo sapiens	95-110
24722377-8	2014	Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARalpha.	Chalcones	16-25	serine/threonine kinase 11	Homo sapiens	112-116
24722377-8	2014	Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARalpha.	Chalcones	16-25	sterol regulatory element binding transcription factor 1	Homo sapiens	142-149
24722377-8	2014	Moreover, these chalcones increased phosphorylation of AMP-activated protein kinase (AMPK) and liver kinase B1 (LKB1), upstream regulators of SREBP-1 and PPARalpha.	Chalcones	16-25	peroxisome proliferator activated receptor alpha	Homo sapiens	154-163
23330659-0	2013	In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II.	Chalcones	35-44	carbonic anhydrase 1	Homo sapiens	60-87
24920885-0	2014	Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position.	Chalcones	24-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	55-87
24920885-0	2014	Quinoxaline-substituted chalcones as new inhibitors of breast cancer resistance protein ABCG2: polyspecificity at B-ring position.	Chalcones	24-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	88-93
24920885-1	2014	A series of chalcones substituted by a quinoxaline unit at the B-ring were synthesized and tested as inhibitors of breast cancer resistance protein-mediated mitoxantrone efflux.	Chalcones	12-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	115-147
24675137-0	2014	Chalcones with electron-withdrawing and electron-donating substituents: anticancer activity against TRAIL resistant cancer cells, structure-activity relationship analysis and regulation of apoptotic proteins.	Chalcones	0-9	TNF superfamily member 10	Homo sapiens	100-105
24628502-1	2014	The possible reaction mechanisms of stereoselective [4 + 2] cycloaddition of enals and chalcones catalyzed by N-heterocyclic carbene (NHC) have been investigated using density functional theory (DFT).	Chalcones	87-96	high mobility group nucleosomal binding domain 4	Homo sapiens	110-138
25756670-10	2014	In addition, in the case of chalcones, the results suggest that the affinity toward P-gp of such compounds is mainly governed by intermolecular dispersive interactions at the binding site.	Chalcones	28-37	phosphoglycolate phosphatase	Homo sapiens	84-88
24169316-6	2013	The chromenylchalcone scaffold, which is derived from natural products including isoflavonoids and chalcones, had not been previously reported as an MAO-B inhibitor.	Chalcones	99-108	monoamine oxidase B	Homo sapiens	149-154
24613626-2	2014	Despite a large number of structurally and functionally diverse compounds, also flavonoids and chalcones have been reported as inhibitors of P-gp.	Chalcones	95-104	ATP binding cassette subfamily B member 1	Homo sapiens	141-145
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	MDM2 proto-oncogene	Homo sapiens	66-70
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	tumor protein p53	Homo sapiens	71-74
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	signal transducer and activator of transcription 3	Homo sapiens	189-194
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	196-200
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	NFE2 like bZIP transcription factor 2	Homo sapiens	202-206
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	peroxisome proliferator activated receptor gamma	Homo sapiens	216-226
24467530-4	2014	These pathways and targets that are affected by chalcones include MDM2/p53, tubulin, proteasome, NF-kappa B, TRIAL/death receptors and mitochondria mediated apoptotic pathways, cell cycle, STAT3, AP-1, NRF2, AR, ER, PPAR-gamma and beta-catenin/Wnt.	Chalcones	48-57	catenin beta 1	Homo sapiens	231-243
24134853-8	2013	Both chalcones increased Bax/Bcl2 ratios and decreased Ki67 and CD71 antigen expressions.	Chalcones	5-14	BCL2 associated X, apoptosis regulator	Homo sapiens	25-28
24134853-8	2013	Both chalcones increased Bax/Bcl2 ratios and decreased Ki67 and CD71 antigen expressions.	Chalcones	5-14	BCL2 apoptosis regulator	Homo sapiens	29-33
24134853-8	2013	Both chalcones increased Bax/Bcl2 ratios and decreased Ki67 and CD71 antigen expressions.	Chalcones	5-14	transferrin receptor	Homo sapiens	64-68
23339572-4	2013	HO-1 expression is triggered by the Nrf2-Keap1 signalling pathway, initiated by the addition of chalcones to thiol groups of Keap1 via Michael-type reaction.	Chalcones	96-105	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
24243608-4	2013	In addition, it was also demonstrated that some of these chalcones are moderate inhibitors of cathepsin K and have no activity against cathepsin B.	Chalcones	57-66	cathepsin K	Homo sapiens	94-105
23877542-5	2013	We showed that synthetic chalcones induced an activation of caspase-9 but not caspase-8 in PC-3 cells.	Chalcones	25-34	caspase 9	Homo sapiens	60-69
23339572-4	2013	HO-1 expression is triggered by the Nrf2-Keap1 signalling pathway, initiated by the addition of chalcones to thiol groups of Keap1 via Michael-type reaction.	Chalcones	96-105	kelch like ECH associated protein 1	Homo sapiens	41-46
23339572-4	2013	HO-1 expression is triggered by the Nrf2-Keap1 signalling pathway, initiated by the addition of chalcones to thiol groups of Keap1 via Michael-type reaction.	Chalcones	96-105	kelch like ECH associated protein 1	Homo sapiens	125-130
23639652-0	2013	Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors.	Chalcones	10-19	yopH	Yersinia enterocolitica	79-83
23844408-3	2013	The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).	Chalcones	36-45	chaperonin containing TCP1 subunit 4	Homo sapiens	92-108
23844408-3	2013	The cytotoxicity bioassays of these chalcones and 5-deoxyflavonoids were screened using the sulforhodamine B (SRB) protein staining method, and the results showed that compounds 2, 4, 5, 6, 10, 15, and 19 exhibited moderate cytotoxicity against the cancer cell line of MDA-MB-231, U251, BGC-823, and B16 in comparison with control drugs (HCPT, Vincristine, and Taxol).	Chalcones	36-45	chaperonin containing TCP1 subunit 4	Homo sapiens	110-113
23608763-0	2013	Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.	Chalcones	0-9	cathepsin B	Homo sapiens	46-57
23360090-1	2013	New imines, derived from aromatic aldehyde, chalcones and 5-amino-1,3,4-thiadiazole-2-thiol exhibited promising anti-convulsant activity which is explained through chemo-biological interactions at receptor site producing the inhibition of human Carbonic Anhydrase-II enzyme (hCA-II) through the proposed pharmacophore model at molecular levels as basis for pharmacological activity.	Chalcones	44-53	carbonic anhydrase 2	Homo sapiens	245-266
23360090-1	2013	New imines, derived from aromatic aldehyde, chalcones and 5-amino-1,3,4-thiadiazole-2-thiol exhibited promising anti-convulsant activity which is explained through chemo-biological interactions at receptor site producing the inhibition of human Carbonic Anhydrase-II enzyme (hCA-II) through the proposed pharmacophore model at molecular levels as basis for pharmacological activity.	Chalcones	44-53	carbonic anhydrase 2	Homo sapiens	275-281
23368840-1	2013	A one-pot cascade transformation of chalcones into beta-imidoketones has been developed, in which NBS provides both electrophilic bromine and nucleophilic nitrogen sources, and DBU functions as a nucleophilic reagent to activate NBS to be a more electrophilic bromine species and to further remove the bromine of alpha-bromoketones.	Chalcones	36-45	nibrin	Homo sapiens	98-101
23330926-11	2013	4) For chalcones, the C-3"-, and C-8- positions undergo hydroxylation.	Chalcones	7-16	complement C3	Homo sapiens	22-25
23330926-11	2013	4) For chalcones, the C-3"-, and C-8- positions undergo hydroxylation.	Chalcones	7-16	homeobox C8	Homo sapiens	33-36
23330926-12	2013	The C-8- position is a very active site for metabolism of chalcones.	Chalcones	58-67	homeobox C8	Homo sapiens	4-7
23805528-1	2013	OBJECTIVE: To study the effect of chalcones extracted from Angelica Keiskei (AC) on the mRNA expression of phosphatidy I inositol 3-kinase (PI3K) and serine-threonine kinases (Akt) in hepatocytes of rats with diabetes.	Chalcones	34-43	AKT serine/threonine kinase 1	Rattus norvegicus	176-179
23368840-1	2013	A one-pot cascade transformation of chalcones into beta-imidoketones has been developed, in which NBS provides both electrophilic bromine and nucleophilic nitrogen sources, and DBU functions as a nucleophilic reagent to activate NBS to be a more electrophilic bromine species and to further remove the bromine of alpha-bromoketones.	Chalcones	36-45	nibrin	Homo sapiens	229-232
23368840-2	2013	The whole process involves tandem bromoamination and debromination, which represents a unique example of preparing beta-aminoketones by the reaction of chalcones with the NBS/DBU combination.	Chalcones	152-161	nibrin	Homo sapiens	171-174
23183544-0	2013	Effects of structural and electronic characteristics of chalcones on the activation of peroxisome proliferator-activated receptor gamma.	Chalcones	56-65	peroxisome proliferator activated receptor gamma	Homo sapiens	87-135
23183544-1	2013	Chalcones share some structural similarities with GW-1929, a highly-selective and potent agonist for peroxisome proliferator-activated receptor-gamma (PPARgamma).	Chalcones	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	101-149
23183544-1	2013	Chalcones share some structural similarities with GW-1929, a highly-selective and potent agonist for peroxisome proliferator-activated receptor-gamma (PPARgamma).	Chalcones	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	151-160
23183544-2	2013	In this study, we tested 53 structurally diverse chalcones to identify characteristics essential for PPARgamma activation in a GAL4-based transactivation assay.	Chalcones	49-58	peroxisome proliferator activated receptor gamma	Homo sapiens	101-110
23183544-4	2013	Our results indicate that chalcones with an electron rich group or sterically large groups such as naphthyl on the carbonyl side tend to activate PPARgamma.	Chalcones	26-35	peroxisome proliferator activated receptor gamma	Homo sapiens	146-155
23183544-5	2013	The absence of any strict structural or electronic requirements suggests that the flexibility of the PPARgamma ligand binding pocket may allow binding of diverse chalcones with some preference for a slightly larger electron-rich group on the carbonyl side.	Chalcones	162-171	peroxisome proliferator activated receptor gamma	Homo sapiens	101-110
23183544-6	2013	We predict that further structure-activity relationship studies on chalcones with naphthalene or electron-rich groups near the carbonyl moiety will lead to the development of more potent PPARgamma agonists.	Chalcones	67-76	peroxisome proliferator activated receptor gamma	Homo sapiens	187-196
22710558-0	2012	Natural chalcones as dual inhibitors of HDACs and NF-kappaB.	Chalcones	8-17	nuclear factor kappa B subunit 1	Homo sapiens	50-59
23203129-11	2012	Chalcones enhance TRAIL-induced apoptosis in HeLa cells through increased expression of  TRAIL-R2.	Chalcones	0-9	TNF superfamily member 10	Homo sapiens	18-23
23203129-11	2012	Chalcones enhance TRAIL-induced apoptosis in HeLa cells through increased expression of  TRAIL-R2.	Chalcones	0-9	TNF receptor superfamily member 10b	Homo sapiens	89-97
23203129-12	2012	Our study has indicated that chalcones augment the antitumor activity of TRAIL and confirm their cancer chemopreventive properties.	Chalcones	29-38	TNF superfamily member 10	Homo sapiens	73-78
23285667-2	2012	The chalcones B1-13 have been synthesized by the condensation of 2-[2-(2, 6-dichloro phenyl)amino]phenylmethyl-3-acetamido-6,8-dibromoquinazolin-4(3H)-one A with different substituted aromatic aldehydes.	Chalcones	4-13	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	14-19
22854194-2	2012	The chalcones and flavanones were screened against mycobacterial FAS-II pathway using a recombinant mycobacterial strain, against which the most potent compound showed ~88% inhibition in bacterial growth and substantially induction of reporter gene activity at 100 muM concentration.	Chalcones	4-13	latexin	Homo sapiens	265-268
23203129-0	2012	Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells.	Chalcones	37-46	TNF receptor superfamily member 10b	Homo sapiens	25-33
23203129-0	2012	Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells.	Chalcones	37-46	TNF superfamily member 10	Homo sapiens	25-30
23203129-5	2012	Chalcones can sensitize cancer cells to TRAIL-induced apoptosis.	Chalcones	0-9	TNF superfamily member 10	Homo sapiens	40-45
22710558-14	2012	The dual inhibitory potential of the selected chalcones on NF-kappaB and HDACs was             investigated for the first time.	Chalcones	46-55	nuclear factor kappa B subunit 1	Homo sapiens	59-68
22677029-0	2012	A SAR study on a series of synthetic lipophilic chalcones as inhibitor of transcription factor NF-kappaB.	Chalcones	48-57	sarcosinemia autosomal recessive	Mus musculus	2-5
22677029-0	2012	A SAR study on a series of synthetic lipophilic chalcones as inhibitor of transcription factor NF-kappaB.	Chalcones	48-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
22470321-3	2012	Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH(3)R in the same concentration range like the reference antagonist ciproxifan (hH(3)R pK(i) value of 7.2).	Chalcones	58-67	histamine receptor H3	Homo sapiens	90-96
22190402-0	2012	Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-alpha induced expression of ICAM-1: structure-activity analysis.	Chalcones	53-62	tumor necrosis factor	Homo sapiens	71-80
22190402-0	2012	Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-alpha induced expression of ICAM-1: structure-activity analysis.	Chalcones	53-62	intercellular adhesion molecule 1	Homo sapiens	103-109
22449016-0	2012	Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.	Chalcones	17-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	58-90
22470321-3	2012	Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH(3)R in the same concentration range like the reference antagonist ciproxifan (hH(3)R pK(i) value of 7.2).	Chalcones	58-67	histamine receptor H3	Homo sapiens	171-177
22410118-3	2012	Among the derivatives, 1,3-diphenylpropenone (DPhP) was most efficacious, and it significantly suppressed TNF-alpha-induced production of IL-8 which is a proinflammatory and proangiogenic cytokine.	Chalcones	23-44	tumor necrosis factor	Homo sapiens	106-115
22410118-3	2012	Among the derivatives, 1,3-diphenylpropenone (DPhP) was most efficacious, and it significantly suppressed TNF-alpha-induced production of IL-8 which is a proinflammatory and proangiogenic cytokine.	Chalcones	23-44	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
22410118-0	2012	1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression of NF-kappaB activation and IL-8 induction.	Chalcones	0-21	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
22410118-3	2012	Among the derivatives, 1,3-diphenylpropenone (DPhP) was most efficacious, and it significantly suppressed TNF-alpha-induced production of IL-8 which is a proinflammatory and proangiogenic cytokine.	Chalcones	46-50	tumor necrosis factor	Homo sapiens	106-115
22410118-3	2012	Among the derivatives, 1,3-diphenylpropenone (DPhP) was most efficacious, and it significantly suppressed TNF-alpha-induced production of IL-8 which is a proinflammatory and proangiogenic cytokine.	Chalcones	46-50	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
22410118-6	2012	In the colon tissue, DPhP inhibited TNBS-induced NF-kappaB nuclear translocation, IL-8 and TNF-alpha expressions, and abnormal angiogenesis.	Chalcones	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	82-86
22410118-6	2012	In the colon tissue, DPhP inhibited TNBS-induced NF-kappaB nuclear translocation, IL-8 and TNF-alpha expressions, and abnormal angiogenesis.	Chalcones	21-25	tumor necrosis factor	Homo sapiens	91-100
22410118-7	2012	In addition, DPhP also suppressed IL-8-induced angiogenesis, which was revealed by an in vivo assay using chick chorioallantoic membrane.	Chalcones	13-17	interleukin 8-like 2	Gallus gallus	34-38
22410118-8	2012	Furthermore, the level of IL-6, a pleiotropic cytokine which is implicated in the pathogenesis of IBD and colitis-associated cancer, was suppressed by DPhP in rat colon tissue and serum.	Chalcones	151-155	interleukin 6	Rattus norvegicus	26-30
22410118-9	2012	In conclusion, the results suggest that DPhP is a potential dual-acting IBD drug candidate targeting both inflammation and abnormal angiogenesis, possibly through the NF-kappaB and IL-8 signaling pathway.	Chalcones	40-44	C-X-C motif chemokine ligand 8	Homo sapiens	181-185
22112540-0	2012	Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein.	Chalcones	17-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	63-95
22200628-6	2012	The most effective compound DPhP, also known as chalcone, showed weak VEGF receptor tyrosine kinase activity compared with the specific inhibitor, SU4312 (3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one).	Chalcones	28-32	vascular endothelial growth factor A	Homo sapiens	70-74
22200628-7	2012	However, DPhP also inhibited several other receptor tyrosine kinases including Tie-2, epithermal growth factor (EGF) receptor, EphB2, fibroblast growth factor (FGF) receptor 3 and insulin-like growth factor-1 (IGF-1) receptor, as revealed by a receptor tyrosine kinase array assay.	Chalcones	9-13	TEK receptor tyrosine kinase	Homo sapiens	79-84
22200628-7	2012	However, DPhP also inhibited several other receptor tyrosine kinases including Tie-2, epithermal growth factor (EGF) receptor, EphB2, fibroblast growth factor (FGF) receptor 3 and insulin-like growth factor-1 (IGF-1) receptor, as revealed by a receptor tyrosine kinase array assay.	Chalcones	9-13	epidermal growth factor receptor	Homo sapiens	86-125
22200628-7	2012	However, DPhP also inhibited several other receptor tyrosine kinases including Tie-2, epithermal growth factor (EGF) receptor, EphB2, fibroblast growth factor (FGF) receptor 3 and insulin-like growth factor-1 (IGF-1) receptor, as revealed by a receptor tyrosine kinase array assay.	Chalcones	9-13	EPH receptor B2	Homo sapiens	127-132
22200628-7	2012	However, DPhP also inhibited several other receptor tyrosine kinases including Tie-2, epithermal growth factor (EGF) receptor, EphB2, fibroblast growth factor (FGF) receptor 3 and insulin-like growth factor-1 (IGF-1) receptor, as revealed by a receptor tyrosine kinase array assay.	Chalcones	9-13	fibroblast growth factor receptor 3	Homo sapiens	134-175
22200628-7	2012	However, DPhP also inhibited several other receptor tyrosine kinases including Tie-2, epithermal growth factor (EGF) receptor, EphB2, fibroblast growth factor (FGF) receptor 3 and insulin-like growth factor-1 (IGF-1) receptor, as revealed by a receptor tyrosine kinase array assay.	Chalcones	9-13	insulin like growth factor 1 receptor	Homo sapiens	180-225
22200628-10	2012	These results suggest that the simple flavonoid, DPhP (chalcone), has valuable potential as an antiangiogenic and anti-cancer agent, and its action is mediated through the inhibition of multi-target RTKs including VEGF receptor 2.	Chalcones	49-53	vascular endothelial growth factor A	Homo sapiens	214-218
22177409-3	2012	Chalcones were tested for their growth inhibitory activity in three human tumor cell lines (MCF-7, NCI-H460 and A375-C5) using the SRB assay.	Chalcones	0-9	chaperonin containing TCP1 subunit 4	Homo sapiens	131-134
22112540-4	2012	The aim of the current study was to investigate different multi-substituted chalcones for their BCRP inhibition.	Chalcones	76-85	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	96-100
22963624-2	2012	The aim of this study was to evaluate chalcones as inhibitors of the chlorinating activity of MPO using in vitro and ex vivo assays.	Chalcones	38-47	myeloperoxidase	Homo sapiens	94-97
23018855-7	2012	Compared to chalcone 1, chalcones 2 and 3, which possess 3"-substituted isoprenyl or bulky 2-benzoylbiphenyl, showed significantly decreased tyrosinase activity, while chalcone 4, possessing 3"-substituted 2-hydroxy-1-pentene group, showed slightly increased activity.The effects of chalcones 1-4 on melanin synthesis, without affecting cell growth, were assayed in melanin-producing B16 murine melanoma cells.	Chalcones	24-33	tyrosinase	Mus musculus	141-151
21988173-3	2011	QSAR study revealed that the presence of electron-withdrawing groups in B-ring and electron-donating groups in A-ring of chalcones was important for inhibition of LPS-induced IL-6 expression.	Chalcones	121-130	interleukin 6	Homo sapiens	175-179
21714592-5	2011	The classification in this review includes COX-2 inhibitors based on five- and six-membered heterocycles, benzoheterocycles (e.g., benzopyrans, benzopyranones, indoles and quinolines), quinones, chalcones, natural products and miscellaneous.	Chalcones	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48
21952533-0	2011	Binding of citrus flavanones and their glucuronides and chalcones to human serum albumin.	Chalcones	56-65	albumin	Homo sapiens	75-88
20938990-5	2011	Next, we investigated the effect of these chalcones on the translocation of GLUT4 and its underlying mechanisms.	Chalcones	42-51	solute carrier family 2 member 4	Rattus norvegicus	76-81
21184149-2	2011	METHODS: From a series of 21 chalcones, the effects of the three best inhibitors of PC-3 and LNCaP cell viability on growth, including cell cycle changes, adhesion, migration, and cell invasion, as well as their ability to inhibit angiogenesis, clonogenic activity, and matrix metalloproteinases MMP-2 and MMP-9, were tested.	Chalcones	29-38	chromobox 8	Homo sapiens	84-88
21547675-0	2011	Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-alpha-stimulated MG-63 cell.	Chalcones	0-9	interleukin 6	Homo sapiens	65-69
21547675-0	2011	Chalcones isolated from Angelica keiskei and their inhibition of IL-6 production in TNF-alpha-stimulated MG-63 cell.	Chalcones	0-9	tumor necrosis factor	Homo sapiens	84-93
21782455-0	2011	Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.	Chalcones	78-87	angiotensin I converting enzyme	Homo sapiens	105-134
21782455-0	2011	Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.	Chalcones	78-87	angiotensin I converting enzyme	Homo sapiens	136-139
21782455-4	2011	Screening all 36 new compounds using ACE inhibition assay, resulted chalcones with better ACE inhibitory activity compared to the respective pyrazole analogues.	Chalcones	68-77	angiotensin I converting enzyme	Homo sapiens	37-40
21782455-4	2011	Screening all 36 new compounds using ACE inhibition assay, resulted chalcones with better ACE inhibitory activity compared to the respective pyrazole analogues.	Chalcones	68-77	angiotensin I converting enzyme	Homo sapiens	90-93
21441032-2	2011	Mannich bases of heterocyclic chalcones inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-gamma stimulated RAW 264.7 macrophages.	Chalcones	30-39	interferon gamma	Homo sapiens	105-121
20938990-6	2011	The chalcones increased the GLUT4 level in the plasma membrane of L6 cells, but activated neither protein kinase C zeta/lambda, Akt, nor adenosine monophosphate-activated protein kinase, all of which regulate the GLUT4 translocation.	Chalcones	4-13	solute carrier family 2 member 4	Rattus norvegicus	28-33
20938990-6	2011	The chalcones increased the GLUT4 level in the plasma membrane of L6 cells, but activated neither protein kinase C zeta/lambda, Akt, nor adenosine monophosphate-activated protein kinase, all of which regulate the GLUT4 translocation.	Chalcones	4-13	solute carrier family 2 member 4	Rattus norvegicus	213-218
20005707-1	2010	A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase.	Chalcones	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-182
21112783-6	2011	This study reports the HIF-1 inhibitory activities of a panel of chalcones, identifies a few lead candidates of single-digit micromolar potency, and determines important structural modifications.	Chalcones	65-74	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-28
21728961-4	2011	Quantitative structure-activity relationships of the ability of flavones, chalcones, xanthones, acridones and various benzopyrane/benzofurane derivatives to inhibit ABCG2-mediated drug efflux have led to pharmacophores and molecular models allowing to optimize the available hit compounds and to design new-generation lead compounds.	Chalcones	74-83	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	165-170
20566231-1	2010	With the aim to further improve the vasorelaxant activities of chalcones, nine hybrid chalcone derivatives conjugated with nitric oxide (NO) donor or 1,4-dihydropyridyl (1,4-DHP) moiety were designed and synthesized based on molecular hybridization strategy.	Chalcones	63-72	dihydropyrimidinase	Homo sapiens	174-177
20221513-1	2010	The first direct organocatalytic asymmetric vinylogous Michael addition reactions of gamma-butenolides to chalcones have been developed by using chiral 1,2-diaminocyclohexane as a novel organocatalyst via a di-iminium transition state to provide syn-Michael products with good yields, high diastereoselectivities and enantioselectivities (up to 78% yield, >99 : 1 dr and 96% ee).	Chalcones	106-115	synemin	Homo sapiens	246-249
20578711-0	2010	Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.	Chalcones	55-64	cathepsin V	Homo sapiens	88-99
20681544-2	2010	Here we compared the effects of chalcones on the expression of the pi class of glutathione S-transferase (GSTP) in rat primary hepatocytes.	Chalcones	32-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	79-104
20681544-2	2010	Here we compared the effects of chalcones on the expression of the pi class of glutathione S-transferase (GSTP) in rat primary hepatocytes.	Chalcones	32-41	glutathione S-transferase pi 1	Rattus norvegicus	106-110
20667741-0	2010	Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.	Chalcones	59-68	arachidonate 5-lipoxygenase	Homo sapiens	72-77
20667741-5	2010	5-LOX in vitro inhibition assay showed higher potency of di-O-prenylated chalcones than their mono-O-prenylated chalcone analogs.	Chalcones	73-82	arachidonate 5-lipoxygenase	Homo sapiens	0-5
20714300-0	2010	Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells.	Chalcones	0-9	TNF superfamily member 10	Homo sapiens	39-44
20714300-3	2010	We examined the cytotoxic and apoptotic effect of chalcones and dihydrochalcones on TRAIL-mediated apoptosis in LNCaP prostate cancer cells.	Chalcones	50-59	TNF superfamily member 10	Homo sapiens	84-89
20167484-0	2010	The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.	Chalcones	77-86	angiotensin I converting enzyme	Homo sapiens	4-47
20167484-0	2010	The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.	Chalcones	77-86	angiotensin I converting enzyme	Homo sapiens	49-52
19735647-5	2010	hCNT3 was the only transporter that exhibited moderate sensitivity to the chalcones tested.	Chalcones	74-83	solute carrier family 28 member 3	Homo sapiens	0-5
20005707-5	2010	Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2.	Chalcones	12-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
20005707-5	2010	Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2.	Chalcones	12-21	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	199-204
20005707-5	2010	Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2.	Chalcones	12-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	220-225
20005707-1	2010	A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase.	Chalcones	38-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	184-189
20005707-1	2010	A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase.	Chalcones	38-47	glucuronidase beta	Homo sapiens	204-222
20005707-4	2010	Overall, the results of the studies reveal that the chalcones with N-methyl piperazine methyl and piperidine methyl substitution (4c, 3b, 4d, 6b) seems to be important for inhibition of beta-glucuronidase.	Chalcones	52-61	glucuronidase beta	Homo sapiens	186-204
19853459-3	2009	An extensive structure-relationship study was performed and revealed that several chalcones and aurones possess an appealing pharmacological profile combining high antioxidant and lipid peroxidation activity with potent soybean LOX inhibition.	Chalcones	82-91	seed linoleate 9S-lipoxygenase-3	Glycine max	228-231
20161998-0	2009	Chalcones enhance TRAIL-induced apoptosis in prostate cancer cells.	Chalcones	0-9	TNF superfamily member 10	Homo sapiens	18-23
20161998-6	2009	Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.	Chalcones	38-47	TNF superfamily member 10	Homo sapiens	131-136
20161998-6	2009	Our study showed that all five tested chalcones: chalcone, licochalcone-A, isobavachalcone, xanthohumol, butein markedly augmented TRAIL-mediated apoptosis and cytotoxicity in prostate cancer cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.	Chalcones	236-245	TNF superfamily member 10	Homo sapiens	131-136
19173220-4	2009	The results suggested the following structural requirements of chalcones (1 and 2) and homoisoflavones (3-9) for anti-allergic activity: (i) chalcone exhibited higher activity than homoisoflavone (ii) vicinal hydroxylation at B-ring of chalcone conferred higher activity than one hydroxylation; and (iii) for homoisoflavone, the hydroxyl groups at C-3 and C-4 positions decreased the activity.	Chalcones	63-72	complement C4A	Rattus norvegicus	356-359
19799548-0	2009	Kinetic and theoretical study of the chalcones as inhibitors of beta-lactamase enzyme.	Chalcones	37-46	beta-lactamase	Escherichia coli	64-78
19757822-1	2009	This paper describes the synthesis and biological evaluation of fluoro-pegylated (FPEG) chalcones for the imaging of beta-amyloid (Abeta) plaques in patients with Alzheimer"s disease (AD).	Chalcones	88-97	amyloid beta precursor protein	Homo sapiens	131-136
18243420-0	2008	Chemotherapy of leishmaniasis part-VIII: synthesis and bioevaluation of novel chalcones.	Chalcones	78-87	cytochrome c oxidase subunit 8A	Homo sapiens	35-39
19483325-6	2009	CH-3, CH-4, and CH-7 significantly activated caspase-3 at 12 h, subsequently induced apoptosis at 72 h. All chalcones inhibited concanavalin A-induced proliferation of PBMCs dose-dependently.	Chalcones	108-117	caspase 3	Homo sapiens	45-54
19378991-1	2009	A large series of substituted chalcones have been synthesized and tested in vitro for their ability to inhibit human monoamine oxidases A and B (hMAO-A and hMAO-B).	Chalcones	30-39	monoamine oxidase A	Homo sapiens	117-143
19378991-1	2009	A large series of substituted chalcones have been synthesized and tested in vitro for their ability to inhibit human monoamine oxidases A and B (hMAO-A and hMAO-B).	Chalcones	30-39	monoamine oxidase A	Homo sapiens	145-151
19378991-1	2009	A large series of substituted chalcones have been synthesized and tested in vitro for their ability to inhibit human monoamine oxidases A and B (hMAO-A and hMAO-B).	Chalcones	30-39	monoamine oxidase B	Homo sapiens	156-162
19237559-2	2009	A series of catalysts was screened for the enantioselective addition of FNSM to chalcones and the catalysts CN I, CD I, QN I-IV, and QD I were found to enable this reaction, successfully providing exclusive 1,4-addition products stereoselectively in high yields (conversion, diastereomeric ratio, and enantiomeric excess).	Chalcones	80-89	5'-nucleotidase, cytosolic IA	Homo sapiens	108-112
19355962-6	2009	The anti-inflammatory activity of chalcones has been correlated with the induction of heme oxygenase-1 while phlorotannins have been found to inhibit matrix metalloproteinase, which is implicated in arthritis, chronic inflammation, and wrinkle formation.	Chalcones	34-43	heme oxygenase 1	Homo sapiens	86-102
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	cyclin A2	Homo sapiens	92-100
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	cyclin dependent kinase 1	Homo sapiens	105-109
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	H3 histone pseudogene 16	Homo sapiens	158-161
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	interferon alpha inducible protein 27	Homo sapiens	166-169
19275612-3	2009	Immunoblot assay showed that chalcones significantly decreased the expression of cyclin Bl, cyclin A and Cdc2 protein, as well as increased the expression of p21 and p27 in a p53-independent manner, contributing to cell cycle arrest.	Chalcones	29-38	tumor protein p53	Homo sapiens	175-178
18610751-1	2008	The ability of 11 chalcones with 3,4,5-trimethoxy substitution on ring A to inhibit the transport activity of P-glycoprotein was studied.	Chalcones	18-27	ATP binding cassette subfamily B member 1	Homo sapiens	110-124
18598762-3	2008	At 5microM, chalcones with 2,4-dimethoxy groups or 2,4-dihydroxyl groups on ring A were found to increase mitoxantrone accumulation to a greater extent than an established BCRP inhibitor, fumitremorgin C. At the same time, these chalcones had negligible effect on calcein accumulation in P-glycoprotein overexpressing MDCKII cells, indicating their potential as selective BCRP inhibitors.	Chalcones	12-21	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	172-176
18598762-3	2008	At 5microM, chalcones with 2,4-dimethoxy groups or 2,4-dihydroxyl groups on ring A were found to increase mitoxantrone accumulation to a greater extent than an established BCRP inhibitor, fumitremorgin C. At the same time, these chalcones had negligible effect on calcein accumulation in P-glycoprotein overexpressing MDCKII cells, indicating their potential as selective BCRP inhibitors.	Chalcones	12-21	ATP binding cassette subfamily G member 2	Canis lupus familiaris	372-376
18598762-6	2008	A stimulatory effect was mostly observed with chalcones with 2,4-dimethoxy substitution on ring A which were earmarked as good BCRP inhibitors in the MX accumulation and cytotoxicity assays.	Chalcones	46-55	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	127-131
18598762-7	2008	These findings underscore the potential of methoxylated and hydroxylated chalcones as selective and potent inhibitors of BCRP whose mode of action may not involve the inhibition of ATPase activity.	Chalcones	73-82	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	121-125
18591798-3	2008	The in-vitro anti-inflammatory related activities of synthetic chalcones (SCs) were demonstrated by performing inhibition assays of trypsin, beta-glucuronidase and diene conjugates.	Chalcones	63-72	glucuronidase beta	Homo sapiens	141-159
18778079-1	2008	The cerium(IV) ammonium nitrate (CAN)-catalyzed sequential, one-pot reaction between alkylamines, beta-ketoesters, and chalcones afforded cis-4,6-disubstituted 2-alkylaminocyclohexene-1-carboxylic esters with complete diastereoselectivity.	Chalcones	119-128	suppressor of cytokine signaling 6	Homo sapiens	138-143
18602831-2	2008	We synthesized Mannich bases of heterocyclic chalcones (9-47) using a one-step Claisen-Schmidt condensation of heterocyclic aldehydes with Mannich bases of acetophenones, and tested the target compounds for cytotoxicity against three human cancer cell lines (prostate, PC-3; breast, MCF-7; nasopharynx, KB) and a multi-drug resistant subline (KB-VIN).	Chalcones	45-54	long intergenic non-protein coding RNA 1191	Homo sapiens	346-349
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Chalcones	29-38	vascular endothelial growth factor A	Homo sapiens	62-66
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Chalcones	29-38	epidermal growth factor receptor	Homo sapiens	102-106
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Chalcones	29-38	nuclear factor kappa B subunit 1	Homo sapiens	119-127
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Chalcones	29-38	AKT serine/threonine kinase 1	Homo sapiens	135-138
18387817-9	2008	Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFkappaB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.	Chalcones	29-38	mitogen-activated protein kinase 3	Homo sapiens	140-146
18341249-1	2008	Synthetic chalcones (SCs) having different side chains on the 1-(2-Hydroxy-3-(2-hydroxy-cyclohexyl)-4,6 dimethoxy-phenyl(-methanone structure were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity, reducing ability, OH radical scavenging activity, inhibition of polyphenol oxidase (PPO) and formation of diene conjugates.	Chalcones	10-19	protoporphyrinogen oxidase	Homo sapiens	332-350
18289849-0	2008	Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.	Chalcones	39-48	potassium voltage-gated channel subfamily A member 3	Homo sapiens	102-107
18341249-1	2008	Synthetic chalcones (SCs) having different side chains on the 1-(2-Hydroxy-3-(2-hydroxy-cyclohexyl)-4,6 dimethoxy-phenyl(-methanone structure were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity, reducing ability, OH radical scavenging activity, inhibition of polyphenol oxidase (PPO) and formation of diene conjugates.	Chalcones	10-19	protoporphyrinogen oxidase	Homo sapiens	352-355
18031621-0	2007	Structure-based drug design of a novel family of chalcones as PPARalpha agonists: virtual screening, synthesis, and biological activities in vitro.	Chalcones	49-58	peroxisome proliferator activated receptor alpha	Homo sapiens	62-71
17973529-1	2007	The tandem reaction of phenols and chalcones in refluxing TFA gave the flavylium species of 2-hydroxy-2-phenyl-2H-chromenes in moderate to good isolated yields.	Chalcones	35-44	coagulation factor III, tissue factor	Homo sapiens	58-61
17458979-3	2007	However, polyphenols, except for procyanidin, in AP (i.e., catechins, chalcones, and phenol carboxylic acids) showed weak inhibitory activities on pancreatic lipase.	Chalcones	70-79	pancreatic lipase	Homo sapiens	147-164
17064909-0	2007	Structural requirement of chalcones for the inhibitory activity of interleukin-5.	Chalcones	26-35	interleukin 5	Homo sapiens	67-80
17064909-4	2007	To identify structural requirements, 26 chalcones were prepared and their inhibitory activities were tested against IL-5.	Chalcones	40-49	interleukin 5	Homo sapiens	116-120
17964170-0	2008	Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein.	Chalcones	15-24	ATP binding cassette subfamily B member 1	Homo sapiens	52-66
17964170-0	2008	Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein.	Chalcones	15-24	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	71-103
17964170-1	2008	A library of chalcones with basic functionalities were screened for inhibition of P-glycoprotein (Pgp, ABCB1) by the calcein-AM accumulation assay on MDCKII/MDR1 cells.	Chalcones	13-22	PGP	Canis lupus familiaris	82-96
17964170-1	2008	A library of chalcones with basic functionalities were screened for inhibition of P-glycoprotein (Pgp, ABCB1) by the calcein-AM accumulation assay on MDCKII/MDR1 cells.	Chalcones	13-22	PGP	Canis lupus familiaris	98-101
17964170-1	2008	A library of chalcones with basic functionalities were screened for inhibition of P-glycoprotein (Pgp, ABCB1) by the calcein-AM accumulation assay on MDCKII/MDR1 cells.	Chalcones	13-22	ATP binding cassette subfamily B member 1	Canis lupus familiaris	103-108
17964170-7	2008	The basic chalcones were also better Pgp inhibitors than their non-basic counterparts which may in turn be better BCRP inhibitors.	Chalcones	10-19	ATP binding cassette subfamily B member 1	Homo sapiens	37-40
17964170-7	2008	The basic chalcones were also better Pgp inhibitors than their non-basic counterparts which may in turn be better BCRP inhibitors.	Chalcones	10-19	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	114-118
17666802-3	2007	In the present study, to find the optimal chemical structures and to elucidate their action mechanisms, 41 synthetic chalcones having the substituent(s) on A- and B-rings were prepared and their effects on iNOS-catalyzed NO production were evaluated using lipopolysaccharide (LPS)-treated RAW 264.7 cells.	Chalcones	117-126	nitric oxide synthase 2, inducible	Mus musculus	206-210