PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2607150-5	1989	Semiquantitative immunoblot analysis was used to estimate CaM present in various fractions during preparation of EGTA-washed lysed synaptosomal membranes from rat cerebral cortex.	Egtazic Acid	113-117	calmodulin 1	Rattus norvegicus	58-61
2511190-1	1989	alpha-Thrombin induces a dose-dependent rapid transient increase in platelet cytosolic Ca2+ levels, coming solely from intracellular stores, since EGTA has no effect.	Egtazic Acid	147-151	coagulation factor II, thrombin	Homo sapiens	6-14
2585081-6	1989	This effect was inhibited by chelating extracellular calcium [Ca++]e with ethyleneglycol-bis (beta-aminoethylether)-N,N"-tetra-acetic acid (EGTA), indicating that the HG-VPF-induced response resulted from the influx of extracellular calcium.	Egtazic Acid	140-144	vascular endothelial growth factor A	Homo sapiens	170-173
2629468-7	1989	In one case of GPS, which revealed one peak by thrombin and 2 peaks by A-23187 in the presence of 1 mM Ca++, 2 peaks were also noted by thrombin and the luminescence peak become lower, when Ca++ was chelated by EGTA, using the Aequorin method.	Egtazic Acid	211-215	coagulation factor II, thrombin	Homo sapiens	136-144
2511190-6	1989	Upon stimulation with 9 nM thrombin these replenished platelets exhibited no Ca2+ transient, and a slow gradual increase in [Ca2+]in from extracellular stores, a slow alkalinization and depolarization, and partial degranulation, all abolished by extracellular EGTA.	Egtazic Acid	260-264	coagulation factor II, thrombin	Homo sapiens	27-35
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	12-81	carbonic anhydrase 2	Rattus norvegicus	147-150
2512814-8	1989	Superfusion with a calcium-free medium containing ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid inhibited 89 +/- 3% of the ANG II- and 70 +/- 8% of the AVP-induced prostacyclin production, whereas nifedipine (10(-6) M) had no effect.	Egtazic Acid	50-119	angiotensinogen	Rattus norvegicus	147-153
2478302-7	1989	Both secretion of IFN and secretion of granules were absolutely dependent upon extracellular Ca2+: EGTA completely blocked both TcR- and PMA/A23187-induced secretion of IFN and exocytosis of granules.	Egtazic Acid	99-103	interferon alpha 1	Homo sapiens	18-21
2478302-7	1989	Both secretion of IFN and secretion of granules were absolutely dependent upon extracellular Ca2+: EGTA completely blocked both TcR- and PMA/A23187-induced secretion of IFN and exocytosis of granules.	Egtazic Acid	99-103	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	128-131
2478302-7	1989	Both secretion of IFN and secretion of granules were absolutely dependent upon extracellular Ca2+: EGTA completely blocked both TcR- and PMA/A23187-induced secretion of IFN and exocytosis of granules.	Egtazic Acid	99-103	interferon alpha 1	Homo sapiens	169-172
2621620-14	1989	IcK did not inactivate significantly over 6 s. It activated with a less negative threshold than IdK, usually near 0 mV when the pipette solution contained 0.8 mM-EGTA with no added calcium.	Egtazic Acid	162-166	serine/threonine-protein kinase ICK	Oryctolagus cuniculus	0-3
2571613-10	1989	Although neither increased extracellular calcium nor calcium ionophores had an effect, treatment of the cells with the calcium chelator [ethylenebis(oxyethylenenitrilo)]tetraacetic acid decreased p32/6.3 levels in a concentration-dependent manner, suggesting a role for calcium in the normal metabolism of the protein.	Egtazic Acid	137-185	complement component 1, q subcomponent binding protein	Mus musculus	196-203
2551911-11	1989	In these cells, addition of EGTA to the incubation medium prevents both the 45Ca influx and the increase in PA activity induced by bFGF, without affecting its mitogenic activity.	Egtazic Acid	28-32	fibroblast growth factor 2	Bos taurus	131-135
2512682-3	1989	EGTA exposure abolished aggregation to ADP, adrenaline and PAF.	Egtazic Acid	0-4	PCNA clamp associated factor	Homo sapiens	59-62
2558749-7	1989	Addition of exogenous calmodulin to membranes prepared in the presence of EGTA did not have any effect on the PTH-sensitive adenylate cyclase activity, suggesting that endogenous calmodulin was not effectively stripped from the membranes by EGTA treatment.	Egtazic Acid	74-78	calmodulin 1	Rattus norvegicus	22-32
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	12-81	carbonic anhydrase 2	Rattus norvegicus	147-150
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	12-81	carbonic anhydrase 2	Rattus norvegicus	147-150
2552070-7	1989	CGRP, and the enhancement by ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid of the ability of CGRP to antagonize morphine-induced antinociception.	Egtazic Acid	29-93	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	112-116
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	12-81	carbonic anhydrase 2	Rattus norvegicus	147-150
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	83-87	carbonic anhydrase 2	Rattus norvegicus	147-150
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	83-87	carbonic anhydrase 2	Rattus norvegicus	147-150
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	83-87	carbonic anhydrase 2	Rattus norvegicus	147-150
2478028-4	1989	Addition of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or Ca2+ channel blockers significantly reduced cytosolic [Ca2+] changes due to addition of ATP or KCl without depleting Ca2+ stores (shown by ionomycin treatment in a Ca2+-free medium), demonstrating that these responses require Ca2+ influx.	Egtazic Acid	83-87	carbonic anhydrase 2	Rattus norvegicus	147-150
2551183-4	1989	Adding EGTA to the first incubation medium abolishes the effect of carbachol on binding of 125I-VIP.	Egtazic Acid	7-11	VIP peptides	Cavia porcellus	96-99
2506676-12	1989	When cells were treated with H2O2 under conditions where intracellular and extracellular Ca+2 were chelated with BAPTA and EGTA, respectively, the response to Con A was restored.	Egtazic Acid	123-127	carbonic anhydrase 2	Mus musculus	89-93
2510359-3	1989	In the presence of EGTA a calcium mobilization from internal stores can be detected with thrombin and with ALB6, but neither with PL2-49 nor with VI-PL3, whereas platelets still change their shape and release ATP.	Egtazic Acid	19-23	coagulation factor II, thrombin	Homo sapiens	89-97
2792225-3	1989	EGTA blocked the EPO response, suggesting that Ca2+ influx may have followed EPO exposure in these cells.	Egtazic Acid	0-4	erythropoietin	Mus musculus	17-20
2792225-3	1989	EGTA blocked the EPO response, suggesting that Ca2+ influx may have followed EPO exposure in these cells.	Egtazic Acid	0-4	erythropoietin	Mus musculus	77-80
2481733-6	1989	Raising the Ca2(+)-buffering capacity of the intracellular solution with 1 mM-EGTA suppressed the appearance of the sustained oscillations.	Egtazic Acid	77-82	carbonic anhydrase 2	Homo sapiens	12-15
2625326-4	1989	Electrophoresis migration was distinctly different between the sample containing CaCl2 and the sample containing EGTA; pI = 4.35; the quantity of calmodulin required for half maximum activation of 2800 unit of PDE was 15ng.	Egtazic Acid	113-117	calmodulin 1	Homo sapiens	146-156
2474610-4	1989	IgA1 initiated partial or complete lysis (62 to 100%) of nine group C strains by using either normal, hypogammaglobulinemic, factor B-depleted, or properdin-deficient human serum as a C source, but IgA1 was unable to effect killing in serum chelated with 10 mM MgCl2 and 10 mM EGTA.	Egtazic Acid	277-281	immunoglobulin heavy constant alpha 1	Homo sapiens	0-4
2502176-4	1989	Because removal of Ca2+ ions from this protein may also lead to increased flexibility in the four Ca2+ binding regions, we have now characterized the sites of methylation that occur when calmodulin is incubated in buffers with or without the calcium chelator ethylene glycol bis(beta-aminoethyl ether)-N,N,-N",N"-tetraacetic acid (EGTA).	Egtazic Acid	259-329	calmodulin	Bos taurus	187-197
2547804-13	1989	S1,4-6 also binds two actin monomers in calcium and one in EGTA, has weak severing activity but does not nucleate polymerization.	Egtazic Acid	59-63	ribosomal protein S14	Homo sapiens	0-6
2506087-8	1989	In the presence of EGTA (no Ca2+), PGE2 stimulation of LHRH release was abolished and this effect of EGTA was totally reversed by the addition of Ca2+ 2 min after PGE2 exposure and partially reversed (40%) by the addition of Ca2+ 5 min after PGE2 exposure in the presence of EGTA.	Egtazic Acid	19-23	gonadotropin releasing hormone 1	Rattus norvegicus	55-59
2515819-4	1989	The susceptibility of these contractures to the depletion and replenishment of Ca2+ differed: the Cu2+-contracture increased proportionally with rising extracellular Ca2+ concentrations ranging from 2.5 to 12.5 mM and were abolished by 5 mM EGTA.	Egtazic Acid	241-245	immunoglobulin kappa variable 1-35	Mus musculus	98-101
2515819-7	1989	After removal of Ca2+ with 5 mM EGTA, followed by replacement with 2.5 mM Ca2+ for 1 min, the Cu2(+)-contracture was fully restored.	Egtazic Acid	32-36	immunoglobulin kappa variable 1-35	Mus musculus	94-97
2544610-5	1989	The increase in prostacyclin production caused by vasopressin and the augmentation by EGF were both abolished by TMB-8, an antagonist of Ca2+ mobilisation, by EGTA, a chelator of Ca2+ ions, or by incubating cultures in the absence of added Ca2+.	Egtazic Acid	159-163	epidermal growth factor	Homo sapiens	86-89
2668802-3	1989	Co-injections of NAALADase inhibitors, such as quisqualate (Quis), phosphate, dithiothreitol and EGTA were found to prolong the t1/2 of [3H]NAAG, whereas cobalt, a NAALADase activity stimulator, accelerated [3H]NAAG catabolism.	Egtazic Acid	97-101	folate hydrolase 1B (pseudogene)	Homo sapiens	17-26
2668802-3	1989	Co-injections of NAALADase inhibitors, such as quisqualate (Quis), phosphate, dithiothreitol and EGTA were found to prolong the t1/2 of [3H]NAAG, whereas cobalt, a NAALADase activity stimulator, accelerated [3H]NAAG catabolism.	Egtazic Acid	97-101	folate hydrolase 1B (pseudogene)	Homo sapiens	164-173
2547793-6	1989	Furthermore, in the PGE1-treated platelets, ABP was proteolyzed at a slower rate than in control platelets when they were lysed with Triton in the absence of EGTA.	Egtazic Acid	158-162	sex hormone binding globulin	Homo sapiens	44-47
2508056-2	1989	The total CaM measured following homogenization of arterial tissue with EGTA and EGTA/Triton X-100 was 2.58 mumol/kg wet tissue.	Egtazic Acid	72-76	calmodulin 1	Rattus norvegicus	10-13
2508056-2	1989	The total CaM measured following homogenization of arterial tissue with EGTA and EGTA/Triton X-100 was 2.58 mumol/kg wet tissue.	Egtazic Acid	81-85	calmodulin 1	Rattus norvegicus	10-13
2568579-6	1989	Removal of extracellular Ca2+ (with 1mM ethyleneglycol-bis-(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid) immediately after the termination of glutamate exposure and before the appearance of the early signs of neuronal death (post-glutamate period) dramatically reduced neuronal degeneration.	Egtazic Acid	40-109	carbonic anhydrase 2	Rattus norvegicus	25-28
2545192-2	1989	However, even in a Ca2+-free, EGTA-containing solution relatively high concentrations of ET1 induced a weak vasoconstriction, which was markedly but not completely inhibited by pretreatment with caffeine.	Egtazic Acid	30-34	endothelin 1	Homo sapiens	89-92
2502176-4	1989	Because removal of Ca2+ ions from this protein may also lead to increased flexibility in the four Ca2+ binding regions, we have now characterized the sites of methylation that occur when calmodulin is incubated in buffers with or without the calcium chelator ethylene glycol bis(beta-aminoethyl ether)-N,N,-N",N"-tetraacetic acid (EGTA).	Egtazic Acid	331-335	calmodulin	Bos taurus	187-197
2500967-2	1989	The fluorescence intensity of DNS-labeled CaBP was much higher in the presence of excess EGTA than in its Ca2+-bound state.	Egtazic Acid	89-93	S100 calcium binding protein G	Homo sapiens	42-46
2651093-9	1989	K+-stimulated LHRH release from ME fragments from estrogen-treated rats was completely eliminated in Ca2+-free medium containing EGTA.	Egtazic Acid	129-133	gonadotropin releasing hormone 1	Rattus norvegicus	14-18
2500967-6	1989	Lyso-PC attenuated in a concentration-dependent manner the quenching of the fluorescence of the DNS-CaBP by high temperatures and increase of ionic strength in the presence of EGTA.	Egtazic Acid	176-180	S100 calcium binding protein G	Homo sapiens	100-104
2500967-7	1989	Lyso-PL"s generally protected the CaBP from digestion with proteases in the presence of EGTA.	Egtazic Acid	88-92	S100 calcium binding protein G	Homo sapiens	34-38
2500967-3	1989	In the absence of free Ca2+ (with 1 mM EGTA) the fluorescence of the labeled CaBP was greatly enhanced by addition of lysophosphatidylcholine (lyso-PC), lysophosphatidylserine (lyso-PS), or lysophosphatidylinositol (lyso-PI).	Egtazic Acid	39-43	S100 calcium binding protein G	Homo sapiens	77-81
2708448-6	1989	EGTA or CoCl2 only slightly diminished AII-stimulated increases in [Ca2+]i.	Egtazic Acid	0-4	angiotensinogen	Homo sapiens	39-42
2544968-2	1989	The peak concentration of cytosolic free calcium in neutrophils stimulated by FMLP (10(-7) M) after treatment with 4 mM EGTA was inhibited by TPTCl in a dose-dependent manner and completely blocked in the concentration range of 2.5 to 10 microM in the absence of extracellular calcium.	Egtazic Acid	120-124	formyl peptide receptor 1	Homo sapiens	78-82
2466408-3	1989	Substantial ANP secretion persisted in a nominally Ca2+-free medium containing 10 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) and was not diminished by 100 microM ryanodine.	Egtazic Acid	85-154	natriuretic peptide A	Rattus norvegicus	12-15
2538474-5	1989	At equilibrium, 30-40% of the bound 125I-calmodulin remains associated with the flagella after treatment with EGTA or trifluoperazine.	Egtazic Acid	110-114	calmodulin 1	Rattus norvegicus	41-51
2466408-3	1989	Substantial ANP secretion persisted in a nominally Ca2+-free medium containing 10 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) and was not diminished by 100 microM ryanodine.	Egtazic Acid	156-160	natriuretic peptide A	Rattus norvegicus	12-15
2466408-4	1989	In the presence of EGTA, 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) significantly increased ANP secretion; this increment was unaffected by 100 microM ryanodine.	Egtazic Acid	19-23	natriuretic peptide A	Rattus norvegicus	99-102
2470454-7	1989	The contractile activity provoked by SP and physalaemin was inhibited by nifedipine (a Ca2+-entry blocker) and was abolished in Ca2+-free EGTA solution.	Egtazic Acid	138-142	tachykinin 1	Mus musculus	37-39
2537817-4	1989	When the kinase was incubated in the presence of ATP, Ca2+, and CaM before the assay, the enzyme showed activity even in the presence of the Ca2+ chelator ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) and TFP.	Egtazic Acid	155-224	calmodulin	Saccharomyces cerevisiae S288C	64-67
2493484-3	1989	Infusion of calcitonin (0.5 U/h) or EGTA (90 mumol/h) with calcium-free solution increased PTH mRNA levels further (two- to sevenfold) above the levels present in animals infused with calcium-free solution alone.	Egtazic Acid	36-40	parathyroid hormone	Rattus norvegicus	91-94
2537817-4	1989	When the kinase was incubated in the presence of ATP, Ca2+, and CaM before the assay, the enzyme showed activity even in the presence of the Ca2+ chelator ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) and TFP.	Egtazic Acid	226-230	calmodulin	Saccharomyces cerevisiae S288C	64-67
2537817-6	1989	At the highest level of conversion, Ca2+- and CaM-independent kinase activity, which was measured in the presence of EGTA and TFP, was nearly equal to the total kinase activity, which was measured in the presence of Ca2+ and CaM.	Egtazic Acid	117-121	calmodulin	Saccharomyces cerevisiae S288C	46-49
2521636-9	1989	These Ca2+- and phospholipid-binding proteins were selectively extracted with [ethylene-bis(oxyethylene-nitrilo)]tetraacetic acid (EGTA) from cell membranes precipitated in the presence of Ca2+, and they displayed an inhibitory activity against pig pancreas phospholipase A2.	Egtazic Acid	79-129	phospholipase A2 group IB	Homo sapiens	258-274
2521636-9	1989	These Ca2+- and phospholipid-binding proteins were selectively extracted with [ethylene-bis(oxyethylene-nitrilo)]tetraacetic acid (EGTA) from cell membranes precipitated in the presence of Ca2+, and they displayed an inhibitory activity against pig pancreas phospholipase A2.	Egtazic Acid	131-135	phospholipase A2 group IB	Homo sapiens	258-274
2492420-7	1989	When CAM was added to the EGTA-treated membranes, Ca2+ transport activity was comparable to that obtained when CAM was added directly to control, untreated BLMV.	Egtazic Acid	26-30	calmodulin 1	Rattus norvegicus	5-8
2563920-5	1989	Moreover, EGTA and a direct (staurosporine) or a competitive (1-[5-isoquinolinylsulfonyl]-2-methyl piperazine) inhibitor of protein kinase C prevents T cell proliferation accomplished with crosslinked anti-TCR-1 and OKT11.	Egtazic Acid	10-14	sperm motility kinase 1	Mus musculus	206-211
2918023-7	1989	In reconstitution experiments, actin filaments incubated in EGTA with purified fimbrin and villin form smooth-sided bundles containing an apparently random number of filaments.	Egtazic Acid	60-64	plastin 1	Homo sapiens	79-86
2537401-5	1989	Addition of an increasing concentration of calcium chelator, ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid, to the medium inhibited a large fraction (approximately 75%) of PAF receptor-induced [Ca++]i mobilization thus suggesting the majority of [Ca++]i mobilization was originated from extracellular milieu and a small portion (approximately 25%) was originated from intracellular sources.	Egtazic Acid	61-125	PCNA clamp associated factor	Homo sapiens	191-194
2537401-5	1989	Addition of an increasing concentration of calcium chelator, ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid, to the medium inhibited a large fraction (approximately 75%) of PAF receptor-induced [Ca++]i mobilization thus suggesting the majority of [Ca++]i mobilization was originated from extracellular milieu and a small portion (approximately 25%) was originated from intracellular sources.	Egtazic Acid	61-125	carbonic anhydrase 1	Homo sapiens	213-219
2537401-5	1989	Addition of an increasing concentration of calcium chelator, ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid, to the medium inhibited a large fraction (approximately 75%) of PAF receptor-induced [Ca++]i mobilization thus suggesting the majority of [Ca++]i mobilization was originated from extracellular milieu and a small portion (approximately 25%) was originated from intracellular sources.	Egtazic Acid	61-125	carbonic anhydrase 1	Homo sapiens	266-272
2536067-5	1989	The role of extracellular Ca2+ in Fc gamma R(CD16)-dependent induction of lymphokine gene expression has been tested by evaluating production, mRNA accumulation and transcription of IFN-gamma and TNF in NK cells stimulated with Fc gamma R(CD16) ligands and/or rIL-2 in the presence of EGTA.	Egtazic Acid	285-289	Fc gamma receptor IIIa	Homo sapiens	34-49
2535781-3	1989	The increase in ACE was inhibited by 0.2 mM EGTA, 50 microM verapamil and 50 microM nifedipine, and was not associated with changes in cellular cAMP.	Egtazic Acid	44-48	angiotensin I converting enzyme	Bos taurus	16-19
2563262-9	1989	The ATPase is unlike any known mammalian E1E2-type ATPase in that it is not inhibited by ouabain or [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) and it is not activated by Na+, K+, or Ca2+.	Egtazic Acid	101-149	dynein axonemal heavy chain 8	Homo sapiens	4-10
2563262-9	1989	The ATPase is unlike any known mammalian E1E2-type ATPase in that it is not inhibited by ouabain or [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) and it is not activated by Na+, K+, or Ca2+.	Egtazic Acid	101-149	dynein axonemal heavy chain 8	Homo sapiens	51-57
2563262-9	1989	The ATPase is unlike any known mammalian E1E2-type ATPase in that it is not inhibited by ouabain or [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) and it is not activated by Na+, K+, or Ca2+.	Egtazic Acid	151-155	dynein axonemal heavy chain 8	Homo sapiens	4-10
2909247-6	1989	The binding of S100 beta was inhibited by EGTA, but was little affected by trifluoperazine and excess unlabelled S100 beta, whereas that of troponin C was inhibited by trifluoperazine and excess unlabelled troponin C, but was little affected by EGTA.	Egtazic Acid	42-46	S100 calcium binding protein B	Rattus norvegicus	15-24
2563262-9	1989	The ATPase is unlike any known mammalian E1E2-type ATPase in that it is not inhibited by ouabain or [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) and it is not activated by Na+, K+, or Ca2+.	Egtazic Acid	151-155	dynein axonemal heavy chain 8	Homo sapiens	51-57
2909247-6	1989	The binding of S100 beta was inhibited by EGTA, but was little affected by trifluoperazine and excess unlabelled S100 beta, whereas that of troponin C was inhibited by trifluoperazine and excess unlabelled troponin C, but was little affected by EGTA.	Egtazic Acid	245-249	S100 calcium binding protein B	Rattus norvegicus	15-24
2505486-4	1989	Addition of EGTA (0.1 to 1 mM) to the Ca2+-free solution caused a considerable depolarization of the membrane and appearance of fast fluctuations of the membrane potential, grouped in periodically appearing spindles.	Egtazic Acid	12-16	carbonic anhydrase 2	Homo sapiens	38-41
2909247-9	1989	The binding of the calbindins was increased by EGTA and was little affected by trifluoperazine and excess unlabelled calbindin.	Egtazic Acid	47-51	calbindin 1	Rattus norvegicus	19-28
2505486-10	1989	These potentials, appearing in Ca2+-free EGTA-containing solution, probably cause the release of Ca2+ from the intracellular stores in amounts sufficient for the realization of the electromechanical coupling.	Egtazic Acid	41-45	carbonic anhydrase 2	Homo sapiens	97-100
2505486-10	1989	These potentials, appearing in Ca2+-free EGTA-containing solution, probably cause the release of Ca2+ from the intracellular stores in amounts sufficient for the realization of the electromechanical coupling.	Egtazic Acid	41-45	carbonic anhydrase 2	Homo sapiens	31-34
2536235-4	1989	However, a threefold stimulation of uptake by 30 microM calbindin-D9k was found when EGTA-free solutions were used, and changes in free Ca2+ activity or 45Ca2+ specific activity were avoided.	Egtazic Acid	85-89	S100 calcium binding protein G	Rattus norvegicus	56-69
2676645-7	1989	These activities of this toxin were inhibited by ethylenediaminetetraacetic acid (EDTA) and ethyleneglycol-bis-(beta-aminoethylether)N,N"-tetraacetic acid (EGTA), but not by cysteine or soybean trypsin inhibitor (SBTI).	Egtazic Acid	156-160	kunitz trypsin protease inhibitor	Glycine max	194-211
2535815-4	1989	Chelation of extracellular calcium by EGTA blocked the inhibition of PTH by maitotoxin.	Egtazic Acid	38-42	parathyroid hormone	Bos taurus	69-72
2503405-5	1989	Incubation of plasma membranes isolated from cultured human melanoma cells with [gamma-32P]ATP in the presence of Ca2+ and ethylene-bis-(oxyethylenenitrilo)-tetraacetic acid (EGTA) resulted in specific phosphorylation of serine and threonine residues on a 75kDa protein (pp75).	Egtazic Acid	123-173	RAB11 family interacting protein 5	Homo sapiens	271-275
2503405-9	1989	The phosphorylation of pp75 was directly dependent upon the presence of non-ionic detergents, and was influenced by length of incubation and concentration ratio of Ca2+ and EGTA.	Egtazic Acid	173-177	RAB11 family interacting protein 5	Homo sapiens	23-27
2504627-4	1989	The increased [Ca2+]i gradually returned to its resting level within 60 s. The addition of EGTA (0.5-10 mM) to medium induced a marked decrease in the amount of [Ca2+]i mobilized by IFN-beta and a partial decrease by IFN-gamma.	Egtazic Acid	91-95	interferon beta 1	Homo sapiens	182-190
2504627-4	1989	The increased [Ca2+]i gradually returned to its resting level within 60 s. The addition of EGTA (0.5-10 mM) to medium induced a marked decrease in the amount of [Ca2+]i mobilized by IFN-beta and a partial decrease by IFN-gamma.	Egtazic Acid	91-95	interferon gamma	Homo sapiens	217-226
2514212-4	1989	In these homogenates two calmodulin inhibitors, a protein kinase C inhibitor and a neutral thiol proteinase inhibitor, and EGTA were found to markedly reduce the rate of serotonin N-acetyltransferase deactivation.	Egtazic Acid	123-127	aralkylamine N-acetyltransferase	Gallus gallus	170-199
2740290-4	1989	CAM in soybean meal is first extracted with 80% ethanol in the presence of EGTA at room temperature and then chromatographed directly on a polymer 3520 column to yield pure CAM.	Egtazic Acid	75-79	calmodulin	Glycine max	0-3
2562430-3	1989	The Ca2+ chelator ethyleneglycoltetraacetic acid (EGTA) abolishes Ca2+ mobilization, suggesting that almost all Ca2+ mobilized by PAF derives from the external medium.	Egtazic Acid	18-48	PCNA clamp associated factor	Homo sapiens	130-133
2562430-3	1989	The Ca2+ chelator ethyleneglycoltetraacetic acid (EGTA) abolishes Ca2+ mobilization, suggesting that almost all Ca2+ mobilized by PAF derives from the external medium.	Egtazic Acid	50-54	PCNA clamp associated factor	Homo sapiens	130-133
2848828-4	1988	Both S6 kinase activities are cAMP- and Ca2+-independent, and have a requirement for [ethylenebis(oxyethylenenitrilo)]tetraacetic acid.	Egtazic Acid	85-134	ribosomal protein S6 kinase B1	Rattus norvegicus	5-14
3264302-21	1988	Addition of EGTA to the media blocked the potentiation of diOG induced EA 1 expression by these mAb.	Egtazic Acid	12-16	CD69 molecule	Homo sapiens	71-75
3143730-9	1988	Pretreatment of the cells with [ethylene-bis(oxyethylenenitrilo)]tetraacetic acid attenuated angiotensin II- and ionomycin-induced vimentin phosphorylation to the same extent.	Egtazic Acid	31-81	angiotensinogen	Rattus norvegicus	93-107
3143730-9	1988	Pretreatment of the cells with [ethylene-bis(oxyethylenenitrilo)]tetraacetic acid attenuated angiotensin II- and ionomycin-induced vimentin phosphorylation to the same extent.	Egtazic Acid	31-81	vimentin	Rattus norvegicus	131-139
2848809-7	1988	The EGF- and TGF beta-stimulated increases in Ca2+ influx could be blocked by cobalt, cadmium, and [ethylenebis(oxyethylenenitrilo)] tetraacetic acid, but not by specific Ca2+ channel blockers such as nifedipine or verapamil, suggesting that these growth factors do not act via L-type voltage-sensitive calcium channels.	Egtazic Acid	100-149	epidermal growth factor	Rattus norvegicus	4-7
2848809-7	1988	The EGF- and TGF beta-stimulated increases in Ca2+ influx could be blocked by cobalt, cadmium, and [ethylenebis(oxyethylenenitrilo)] tetraacetic acid, but not by specific Ca2+ channel blockers such as nifedipine or verapamil, suggesting that these growth factors do not act via L-type voltage-sensitive calcium channels.	Egtazic Acid	100-149	transforming growth factor, beta 1	Rattus norvegicus	13-21
3217236-3	1988	The phasic contractions induced by both low and high NA concentrations in Ca2+-free solution containing 2 mM EGTA were suppressed by 10 microM ryanodine.	Egtazic Acid	109-113	carbonic anhydrase 2	Oryctolagus cuniculus	74-77
2474070-5	1988	Acetylcholine (ACh, 0.05-0.5 microM) and cholecystokinin octapeptide (CCK-8, 10-50 pM) concomitantly induced transient increases in cell membrane current, capacitance and conductance only when cytosolic Ca2+ was weakly chelated by EGTA (70 microM).	Egtazic Acid	231-235	cholecystokinin	Rattus norvegicus	70-73
2474070-9	1988	The ACh- or CCK-induced responses (with or without GTP gamma S in the cytosol) were all abolished when a high dose of EGTA (1-2 mM) was injected into the acinar cells.	Egtazic Acid	118-122	cholecystokinin	Rattus norvegicus	12-15
2854113-2	1988	Anti-FT-1 induced a rapid and sustained increase in cytosolic free [Ca2+]i and this effect was completely blocked by EGTA and La3+.	Egtazic Acid	117-121	AKT interacting protein	Mus musculus	5-9
2903676-5	1988	EGTA at doses of 2 or 5 mM blocked the BBS-mediated release of both gastrin and SLI.	Egtazic Acid	0-4	gastrin	Rattus norvegicus	68-75
2461641-9	1988	Increases in [Ca2+]i using Ca2+ ionophore A23187 and intracellular injection of CaCl2 or inositol trisphosphate decreased the PTH depolarizing action, whereas intracellular injection of EGTA enhanced this effect.	Egtazic Acid	186-190	parathyroid hormone	Rattus norvegicus	126-129
2846549-4	1988	Ionomycin also transiently elevated pHi and 5-(N-ethyl-N-isopropyl) amiloride-sensitive 22Na+ influx, effects consistent with activation of the antiport; these effects were abolished in cells exposed to calmodulin antagonists or [ethylenebis(oxyethylenenitrilo)]tetraacetic acid.	Egtazic Acid	230-278	calmodulin 1	Rattus norvegicus	203-213
3139288-5	1988	In addition both pro-1 and pro-2 transfectants showed inhibition of phorbol ester induced transformation by antipromoters ganglioside GT1b, ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, and forskolin.	Egtazic Acid	140-209	proline dehydrogenase	Mus musculus	17-22
3147981-6	1988	EGTA, a Ca++ chelator, completely inhibited CD2- and CD3- mediated T-cell proliferation, indicating that calcium uptake is necessary during the T-cell proliferation.	Egtazic Acid	0-4	CD2 molecule	Homo sapiens	44-47
3147981-8	1988	In the CD2 pathway, EGTA-inhibited proliferation of T cells could be completely restored by addition of exogenous interleukin 2 as well as exogenous recombinant interleukin 1.	Egtazic Acid	20-24	CD2 molecule	Homo sapiens	7-10
3147981-8	1988	In the CD2 pathway, EGTA-inhibited proliferation of T cells could be completely restored by addition of exogenous interleukin 2 as well as exogenous recombinant interleukin 1.	Egtazic Acid	20-24	interleukin 2	Homo sapiens	114-127
3147981-8	1988	In the CD2 pathway, EGTA-inhibited proliferation of T cells could be completely restored by addition of exogenous interleukin 2 as well as exogenous recombinant interleukin 1.	Egtazic Acid	20-24	interleukin 1 alpha	Homo sapiens	161-174
3147981-9	1988	Our results indicate that EGTA inhibits the production of interleukin 1 but has no direct effect on either interleukin 2 production or on Tac antigen expression.	Egtazic Acid	26-30	interleukin 1 alpha	Homo sapiens	58-71
3263971-5	1988	Induction of competence to proliferate in response to either PDB or IL-2 was blocked by EGTA, suggesting that transmembrane Ca2+ flux was obligatory at this stage.	Egtazic Acid	88-92	interleukin 2	Homo sapiens	68-72
3139670-3	1988	However, the binding properties differed strikingly from TnC: unlike TnC, CaM binding required the continued presence of Ca2+ and the bound portion was completely released with EGTA in the physiological milieu.	Egtazic Acid	177-181	calmodulin	Oryctolagus cuniculus	74-77
3416815-4	1988	In addition, agents known to inhibit the binding of beta-MSH to its cellular receptor, such as EGTA, GTP, guanosine 5"-O-(3-thio)triphosphate, and a synthetic analog of the calmodulin-binding domain of myosin light chain kinase-M5, were all found to specifically inhibit the labeling of these two protein bands by the azido derivative of [125I]iodo-beta-MSH.	Egtazic Acid	95-99	proopiomelanocortin	Homo sapiens	52-60
2842423-7	1988	A PAF receptor antagonist, SRI 63-441, blocked the increased complement receptor expression in a dose-dependent manner with maximal inhibition of 80-95% at 5 x 10(-6) M. Extracellular calcium had no effect on CR1 expression but slightly enhanced and EGTA partially inhibited the PAF-induced increase in CR3 expression.	Egtazic Acid	250-254	PCNA clamp associated factor	Homo sapiens	2-5
2903676-6	1988	After removal of a low dose of EGTA from the perfusate, the release of both gastrin and SLI rebounded.	Egtazic Acid	31-35	gastrin	Rattus norvegicus	76-83
2903676-7	1988	On removal of a high dose of EGTA, however, SLI release remained depressed, but gastrin rebounded even more significantly.	Egtazic Acid	29-33	gastrin	Rattus norvegicus	80-87
3191528-7	1988	Further, lowering of the extracellular [Ca2+] to less than 1 microM with EGTA abolishes the response of Cai to ATP, though not the response to caffeine.	Egtazic Acid	73-77	carbonic anhydrase 1	Rattus norvegicus	104-107
2848547-6	1988	Phosphocalmodulin, which could be partially extracted from the membrane by EGTA, comigrated with bovine brain calmodulin in polyacrylamide gel electrophoresis.	Egtazic Acid	75-79	calmodulin	Bos taurus	7-17
2847870-5	1988	Basal and A23187-stimulated (100 nM) ODC activity were inhibited by EGTA and trifluoperazine.	Egtazic Acid	68-72	ornithine decarboxylase 1	Rattus norvegicus	37-40
2847870-8	1988	Addition of La3+, verapamil or EGTA, but not of trifluoperazine, significantly inhibited the forskolin-stimulated (10 microM) ODC activity.	Egtazic Acid	31-35	ornithine decarboxylase 1	Rattus norvegicus	126-129
2839618-1	1988	The concentration requirements of calmodulin in altering basal, GTP-, and dopamine-stimulated adenylate cyclase activities in an EGTA-washed particulate fraction from bovine striatum were examined.	Egtazic Acid	129-133	calmodulin	Bos taurus	34-44
2463067-9	1988	These effects could not be explained by a positive interaction of Ca2+ with the hormone-stimulated cAMP system as 2 mM EGTA strongly enhanced PTH-stimulated cAMP production but at the same time completely inhibited PTH-induced ODC activity.	Egtazic Acid	119-123	parathyroid hormone	Gallus gallus	142-145
2846108-8	1988	In the absence of calcium and in the presence of EGTA (1 mM), permeabilised 7315c cells secreted prolactin at a rate of 0.23 ng min-1 per 10(6) cells.	Egtazic Acid	49-53	CD59 molecule (CD59 blood group)	Homo sapiens	128-133
2846108-9	1988	When EGTA was replaced by 1.5 mM calcium, permeabilised cells secreted prolactin at a rate of 2.20 +/- 0.30 ng min-1 per 10(6) cells in the first 5 min of exposure.	Egtazic Acid	5-9	CD59 molecule (CD59 blood group)	Homo sapiens	111-116
2463067-9	1988	These effects could not be explained by a positive interaction of Ca2+ with the hormone-stimulated cAMP system as 2 mM EGTA strongly enhanced PTH-stimulated cAMP production but at the same time completely inhibited PTH-induced ODC activity.	Egtazic Acid	119-123	parathyroid hormone	Gallus gallus	215-218
2463067-9	1988	These effects could not be explained by a positive interaction of Ca2+ with the hormone-stimulated cAMP system as 2 mM EGTA strongly enhanced PTH-stimulated cAMP production but at the same time completely inhibited PTH-induced ODC activity.	Egtazic Acid	119-123	ornithine decarboxylase	Gallus gallus	227-230
3396855-5	1988	In the presence of the Ca antagonists D600 (10(-6) mol/l) and nifedipine (10(-7) mol/l) or in Ca-free medium containing EGTA the effect of bombesin on the frequency of the plateau action potentials and phasic contractions remained unchanged; however, spike potentials were not observed and no increase in the amplitude of phasic contractions occurred.	Egtazic Acid	120-124	gastrin releasing peptide	Homo sapiens	139-147
2898360-6	1988	The stimulation of SRIF release induced by 10(-10) M GRF was not inhibited by omission of extracellular calcium or when the remaining CA+2 was chelated with 10(-4) M EGTA.	Egtazic Acid	166-170	growth hormone releasing hormone	Rattus norvegicus	53-56
2838080-3	1988	In membranes from MNS rats which had been isolated in the presence of EGTA, the ATP-dependent Ca2+ transport showed a hyperbolic Ca2+ concentration dependence, a high Km (Ca2+) and a low Vmax; upon addition of exogenous calmodulin, the kinetics became sigmoidal, the Km (Ca2+) was decreased and the Vmax was increased.	Egtazic Acid	70-74	calmodulin 1	Rattus norvegicus	220-230
2838326-5	1988	In cells pretreated with EGTA, the sustained component of the Ca2+ response was not observed.	Egtazic Acid	25-29	carbonic anhydrase 2	Homo sapiens	62-65
2971350-6	1988	Extraction of endogenous calmodulin from the membranes by EGTA decreased the activity and Ca2+ affinity of the calcium pump; both activity and affinity were fully restored by adding back calmodulin or by limited proteolysis.	Egtazic Acid	58-62	calmodulin 1	Rattus norvegicus	25-35
2896201-7	1988	Gel exclusion chromatography of Pk1 adenylate cyclase gave apparent Stokes radii (RS) of 43.5 A (+/- 1.3) in the presence of 2 mM CaCl2 and 33.8 A (+/- 0.94) in the presence of 2 mM EGTA [( ethylenebis (oxyethylenenitrilo)]tetraacetic acid).	Egtazic Acid	182-186	pyruvate kinase liver and red blood cell	Mus musculus	32-35
2840435-6	1988	However, the effects of calcium channel blockers and EGTA on basal and PTH- and forskolin-induced ODC activity point to a specific role for calcium.	Egtazic Acid	53-57	ornithine decarboxylase 1	Rattus norvegicus	98-101
2840435-7	1988	Moreover, the effects of calcium channel blockers and EGTA on basal and PTH- and forskolin-induced cAMP production indicate that the involvement of calcium in the induction of ODC activity is primarily located at another site than the adenylate cyclase.	Egtazic Acid	54-58	ornithine decarboxylase 1	Rattus norvegicus	176-179
2896201-7	1988	Gel exclusion chromatography of Pk1 adenylate cyclase gave apparent Stokes radii (RS) of 43.5 A (+/- 1.3) in the presence of 2 mM CaCl2 and 33.8 A (+/- 0.94) in the presence of 2 mM EGTA [( ethylenebis (oxyethylenenitrilo)]tetraacetic acid).	Egtazic Acid	190-239	pyruvate kinase liver and red blood cell	Mus musculus	32-35
3291184-10	1988	In the presence of EGTA, only thrombin could induce ATP release from platelets.	Egtazic Acid	19-23	prothrombin	Oryctolagus cuniculus	30-38
2971400-2	1988	Treatment of membranes with 1 mM EGTA in the presence of 0.2 M NaCl causes the diminution of the calmodulin content down to 3% of the original level.	Egtazic Acid	33-37	calmodulin-3	Sus scrofa	97-107
2835170-7	1988	Removal of extracellular Ca2+ by addition of EGTA at the beginning of the culture greatly depressed LGL proliferation and IL-2 production, and blocked phenotypic changes, such as the expression of Tac antigen.	Egtazic Acid	45-49	interleukin 2	Homo sapiens	122-126
2835170-7	1988	Removal of extracellular Ca2+ by addition of EGTA at the beginning of the culture greatly depressed LGL proliferation and IL-2 production, and blocked phenotypic changes, such as the expression of Tac antigen.	Egtazic Acid	45-49	interleukin 2 receptor subunit alpha	Homo sapiens	197-208
2965699-10	1988	Troponin increases the affinity of unacetylated tropomyosin for actin (+Ca2+, Kapp = 6 X 10(6) M-1; +EGTA, Kapp = 2 X 10(7) M-1), but the affinity is still lower than that of muscle tropomyosin for actin in the presence of troponin (Kapp much greater than 10(8) M-1).	Egtazic Acid	101-105	actin, beta	Gallus gallus	64-69
2897969-4	1988	Ca2+/calmodulin stimulated adenylate cyclase activity in EGTA-washed plasma preparations from each region studied--from 1.3-fold (in striatum) to 3.4-fold (in cerebral cortex).	Egtazic Acid	57-61	calmodulin 1	Rattus norvegicus	5-15
2454126-4	1988	Most of the increases of tubule cell Ca2+ produced by hypoxia and ATP were accounted for by pools which could be rapidly removed by exposure of tubules to EGTA and the uncoupler carbonyl cyanide m-chlorophenyl hydrazone without concomitant use of digitonin, suggesting that the changes of Ca2+ predominantly reflect sequestration by mitochondria in severely damaged cells or mitochondria already released to the medium from them.	Egtazic Acid	155-159	carbonic anhydrase 2	Oryctolagus cuniculus	37-40
2454126-4	1988	Most of the increases of tubule cell Ca2+ produced by hypoxia and ATP were accounted for by pools which could be rapidly removed by exposure of tubules to EGTA and the uncoupler carbonyl cyanide m-chlorophenyl hydrazone without concomitant use of digitonin, suggesting that the changes of Ca2+ predominantly reflect sequestration by mitochondria in severely damaged cells or mitochondria already released to the medium from them.	Egtazic Acid	155-159	carbonic anhydrase 2	Oryctolagus cuniculus	289-292
2833275-9	1988	However, this effect appeared much more sensitive to sin 1 in the presence of external Ca2+ (25% at 10(-7) M sin 1 with external Ca2+ against 12% at the same sin 1 concentration with EGTA).	Egtazic Acid	183-187	MAPK associated protein 1	Homo sapiens	53-58
2897969-6	1988	In EGTA-washed membranes, receptor-mediated inhibition of adenylate cyclase was strictly dependent upon Ca2+/calmodulin stimulation in all regions, except striatum.	Egtazic Acid	3-7	calmodulin 1	Rattus norvegicus	109-119
2830313-13	1988	A less likely explanation involves enhancement of intracellular calcium stores in an ionomycin-resistant, EGTA-sensitive, TRH-mobilizable reservoir.	Egtazic Acid	106-110	thyrotropin releasing hormone	Rattus norvegicus	122-125
3386137-5	1988	Chelation of extracellular calcium with EGTA blocked the 1,25-(OH)2D3-induced increase in [Ca]i, suggesting that the increase was mainly from extracellular calcium.	Egtazic Acid	40-44	carbonic anhydrase 1	Bos taurus	91-95
2972172-3	1988	Blockade of calcium activity with 10 microM verapamil and 4 mM EGTA suppressed the frequency and amplitude of the spontaneous pulsatile i beta-endorphin release (n = 2).	Egtazic Acid	63-67	proopiomelanocortin	Homo sapiens	138-152
2447088-8	1988	The permeability responses to EGTA plus uncoupler again require accumulated Ca2+ specifically and are antagonized by inhibitors of phospholipase A2 and by ionophore A23187.	Egtazic Acid	30-34	phospholipase A2 group IB	Rattus norvegicus	131-147
3123488-8	1988	The production of [3H]inositol phosphates by VIP and muscarine occurred in calcium-free and EGTA medium.	Egtazic Acid	92-96	vasoactive intestinal peptide	Rattus norvegicus	45-48
2969420-5	1988	Likewise, autoxidation products of linoleic and arachidonic acids and lipoxygenase-generated products of linoleic acid induced a dose-dependent release of calcium from vesicles previously loaded with 45Ca, and release was further enhanced in the presence of 0.5 mM of EGTA.	Egtazic Acid	268-272	linoleate 9S-lipoxygenase-4	Glycine max	70-82
3367699-3	1988	This Cu2+-dependent inhibition of acid cholesterol ester hydrolase (CEH) activity was completely prevented by ethylenediamine tetraacetic acid (EDTA), EGTA and o-phenanthroline, a chelator with a stability constant for Cu2+, and also by sulfhydryl agents and cytoplasmic reducing agents such as cysteine, glutathione and mercaptoethanol.	Egtazic Acid	151-155	epoxide hydrolase 2	Rattus norvegicus	39-66
3367699-3	1988	This Cu2+-dependent inhibition of acid cholesterol ester hydrolase (CEH) activity was completely prevented by ethylenediamine tetraacetic acid (EDTA), EGTA and o-phenanthroline, a chelator with a stability constant for Cu2+, and also by sulfhydryl agents and cytoplasmic reducing agents such as cysteine, glutathione and mercaptoethanol.	Egtazic Acid	151-155	epoxide hydrolase 2	Rattus norvegicus	68-71
2449430-5	1988	Addition of EGTA to cultures treated with both PDGF and a Ca2+ ionophore did not inhibit c-myc induction but rather caused a superinduction of c-myc RNA accumulation.	Egtazic Acid	12-16	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	143-148
2963011-4	1988	As determined by 125I-calmodulin overlays, ion exchange chromatography, and actin-binding assays, a 90-kD digest fragment generated in EGTA remains associated with calmodulin.	Egtazic Acid	135-139	calmodulin 1	Homo sapiens	22-32
2963011-4	1988	As determined by 125I-calmodulin overlays, ion exchange chromatography, and actin-binding assays, a 90-kD digest fragment generated in EGTA remains associated with calmodulin.	Egtazic Acid	135-139	calmodulin 1	Homo sapiens	164-174
2963011-5	1988	The 90K-calmodulin complex binds actin in an ATP-reversible manner and decorates actin filaments with an arrow-head appearance similar to that found after incubation of F-actin with the parent complex; binding occurs in either calcium- or EGTA-containing buffers.	Egtazic Acid	239-243	calmodulin 1	Homo sapiens	8-18
2447244-4	1988	The effect of PLA2 was prevented by EGTA and two nonselective PLA2 inhibitors, mepacrine and bromophenacyl bromide.	Egtazic Acid	36-40	phospholipase A2 group IB	Rattus norvegicus	14-18
3142380-2	1988	When membranes were isolated in the presence of ethylene glycol (beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA), the amount of calmodulin associated with the plasma membranes was reduced by only 20%.	Egtazic Acid	116-120	calmodulin 1	Homo sapiens	137-147
3123070-2	1988	Chelation of extracellular calcium with EGTA resulted in a failure of PHA to induce a rise in intracytoplasmic calcium, resulting in the fresh T cells in an inhibition of IL-2 production, IL-2 receptor expression, and proliferation.	Egtazic Acid	40-44	interleukin 2 receptor subunit beta	Homo sapiens	188-201
3123070-3	1988	However, cultured T cells grown in recombinant IL-2 were able to re-express IL-2 receptors and proliferate in response to PHA stimulation in the presence of EGTA.	Egtazic Acid	157-161	interleukin 2	Homo sapiens	47-51
3440123-1	1987	The dissociation kinetics of complexes of bovine alpha-lactalbumin and cod parvalbumin with Ca(II) and Mg(II) ions induced by mixing of a Ca(II)- or MG(II)-loaded protein with a chelator of divalent cations (EDTA or EGTA) have been studied by means of the stopped-flow method with intrinsic protein fluorescence registration.	Egtazic Acid	216-220	carbonic anhydrase 2	Bos taurus	92-98
2898831-3	1988	Parathyroid glands were stimulated for parathyroid hormone secretion by decreasing the serum calcium concentration through intravenous infusion of EGTA.	Egtazic Acid	147-151	parathyroid hormone	Rattus norvegicus	39-58
2962537-1	1987	Using as a starting material either a detergent extract or a protein fraction eluted from membranes with ethylene glycol bis (beta-aminoethyl ether)-N,N"-tetraacetic acid, we have isolated from human placental membranes a major substrate for the epidermal growth factor (urogastrone) receptor kinase (EGF kinase).	Egtazic Acid	105-170	epidermal growth factor	Homo sapiens	246-299
3062832-3	1988	The in vitro release of LHRH from medial basal hypothalamic fragments induced by KCl depolarization (56 mM), but not the basal release, was blocked by omission of Ca++ and addition of 0.1 mM EGTA to the incubation medium and also by cobalt (1 mM).	Egtazic Acid	191-195	gonadotropin releasing hormone 1	Rattus norvegicus	24-28
3062832-5	1988	However, the stimulation of LHRH release by NPY (1 microM) still occurred in Ca++ free/EGTA medium.	Egtazic Acid	87-91	gonadotropin releasing hormone 1	Rattus norvegicus	28-32
3062832-5	1988	However, the stimulation of LHRH release by NPY (1 microM) still occurred in Ca++ free/EGTA medium.	Egtazic Acid	87-91	neuropeptide Y	Rattus norvegicus	44-47
3138899-7	1987	The increases in [Ca2+]i induced by both rGRF and NE were inhibited by pretreatment with EGTA or verapamil.	Egtazic Acid	89-93	growth hormone releasing hormone	Rattus norvegicus	41-45
2451738-4	1987	K+ removal from the external medium increased the release of [3H]NA, an action transiently inhibited by Ca2+-free (+1 mM-EGTA) solution, i.e. after Ca2+ removal transmitter release was first abolished and then started to increase again after a delay lasting about 90-120 min.	Egtazic Acid	121-125	carbonic anhydrase 2	Oryctolagus cuniculus	148-151
2824461-2	1987	The relative reactivities of calmodulin lysines were higher in the presence of Ca2+ than in the presence of EGTA, and the order was: Lys-75 greater than Lys-94 greater than Lys-148 greater than or equal to Lys-77 greater than Lys-13 greater than or equal to Lys-21 greater than Lys-30.	Egtazic Acid	108-112	calmodulin 1	Homo sapiens	29-39
2856406-6	1987	The depolarizing response to TRH was not diminished in oocytes incubated in a Ca2(+)-free medium, but was inhibited by microinjection of EGTA.	Egtazic Acid	137-141	thyrotropin releasing hormone	Rattus norvegicus	29-32
2961774-10	1987	Moreover, AMV-p35 extracted directly from microvilli in Triton/EGTA also behaves as a 35,000-dalton menomer.	Egtazic Acid	63-67	annexin A1	Rattus norvegicus	14-17
2446504-5	1987	The GRF (2 nM)-induced elevation of [Ca2+]i was abolished by removal of extracellular calcium (Ca2+ omitted, 2 mM EGTA).	Egtazic Acid	114-118	growth hormone releasing hormone	Rattus norvegicus	4-7
2446509-5	1987	Acini suspended in Ca2+ free buffer containing 0.1 or 0.2 mM ethylene glycol tetraacetic acid showed 0.21 and 0.10 pH unit alkalinization in response to caerulein (10(-10) M) and carbachol (10(-5) M) but no change in pHi after addition of bromo-A23187.	Egtazic Acid	61-93	glucose-6-phosphate isomerase 1	Mus musculus	115-117
2446509-5	1987	Acini suspended in Ca2+ free buffer containing 0.1 or 0.2 mM ethylene glycol tetraacetic acid showed 0.21 and 0.10 pH unit alkalinization in response to caerulein (10(-10) M) and carbachol (10(-5) M) but no change in pHi after addition of bromo-A23187.	Egtazic Acid	61-93	glucose-6-phosphate isomerase 1	Mus musculus	217-220
2958093-6	1987	Cyclic AMP-dependent phosphorylation of the 22-kDa polypeptide was inhibited by the protein kinase inhibitor and calmodulin-dependent phosphorylation was inhibited by chlorpromazine and EGTA.	Egtazic Acid	186-190	calmodulin 1	Homo sapiens	113-123
3118870-2	1987	The dependence of the enzyme activity on Ca++ and calmodulin in vitro, in control rats, is shown by its substantial lowering in the presence of EGTA and inhibition by trifluoperazine (TFP) (IC50 between 10-20 microM).	Egtazic Acid	144-148	calmodulin 1	Rattus norvegicus	50-60
3117977-4	1987	Fractionation of protein carboxylmethyl esters from GH3 cells by gel permeation FPLC, anion-exchange FPLC, and reverse-phase HPLC in the presence of calcium and in the presence of EGTA identified two proteins that are major substrates for protein carboxylmethyltransferase and indicated that one of these proteins is calmodulin.	Egtazic Acid	180-184	calmodulin 1	Rattus norvegicus	317-327
3454868-4	1987	Removal of endogenous calmodulin from the membrane by EGTA extraction resulted in a 2.5 fold increase in calmodulin dependent 32P incorporation into the two proteins in the presence of exogenous calmodulin.	Egtazic Acid	54-58	calmodulin	Oryctolagus cuniculus	22-32
3454868-4	1987	Removal of endogenous calmodulin from the membrane by EGTA extraction resulted in a 2.5 fold increase in calmodulin dependent 32P incorporation into the two proteins in the presence of exogenous calmodulin.	Egtazic Acid	54-58	calmodulin	Oryctolagus cuniculus	105-115
3454868-4	1987	Removal of endogenous calmodulin from the membrane by EGTA extraction resulted in a 2.5 fold increase in calmodulin dependent 32P incorporation into the two proteins in the presence of exogenous calmodulin.	Egtazic Acid	54-58	calmodulin	Oryctolagus cuniculus	105-115
2822412-1	1987	If confluent fibroblasts are infected with the swine alpha-herpes virus, pseudorabies virus, ribosomal protein S6 becomes phosphorylated after a lag of approximately 2 h. When cell-free extracts were prepared from such cells in the presence of glycerol 2-phosphate and EGTA, a ribosomal protein S6 kinase activity was found to appear at approximately the same time as the phosphorylation in vivo.	Egtazic Acid	269-273	ribosomal protein S6	Homo sapiens	93-113
2830423-0	1987	Inhibition of adenosine 3",5"-cyclic monophosphate phosphodiesterase by CD-349, a novel 1,4-dihydropyridine derivative: effect of EGTA on the inhibitory activity.	Egtazic Acid	130-134	frizzled class receptor 9	Homo sapiens	72-78
3308440-5	1987	PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect.	Egtazic Acid	121-125	phospholipase A2 group IB	Rattus norvegicus	0-4
3308440-5	1987	PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect.	Egtazic Acid	121-125	gonadotropin releasing hormone 1	Rattus norvegicus	13-17
3308440-5	1987	PLA2 induced LHRH release in a dose-related manner at amounts of 2, 10, and 50 U. Omission of Ca++ from the medium using EGTA eliminated the PLA2 effect.	Egtazic Acid	121-125	phospholipase A2 group IB	Rattus norvegicus	141-145
2830423-5	1987	In the coronary artery, the inhibition of cyclic AMP PDE by CD-349 was weakened in the presence of EGTA, while the inhibition of nicardipine and nifedipine were not affected.	Egtazic Acid	99-103	frizzled class receptor 9	Homo sapiens	60-66
2821911-5	1987	The enzyme activity was retained on a calmodulin-affinity column in the presence of Ca2+, and was eluted from the column by lowering the free Ca2+ concentration by adding ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid.	Egtazic Acid	171-235	calmodulin-3	Cavia porcellus	38-48
3477543-5	1987	The 1,25-(OH)2D3- and PTH-induced spikes were abolished by the prior addition of EGTA and Ca2+ entry blockers (verapamil, nifedipine, 1 microM) while the responses to 25-(OH)D3, 24,25-(OH)2D3, and PGE2 were unaffected.	Egtazic Acid	81-85	parathyroid hormone	Mus musculus	22-25
3477543-6	1987	Addition of 1,25-(OH)2D3 + EGTA or PTH + EGTA caused enhanced Ca efflux.	Egtazic Acid	41-45	parathyroid hormone	Mus musculus	35-38
3323675-6	1987	The importance of calcium to the metabolic effects of LIF was demonstrated by the abilities of the calmodulin inhibitor trifluoroperazine (51.5% inhibition) and the extracellular calcium chelator EGTA (50.5% inhibition) to suppress LIF-mediated degranulation.	Egtazic Acid	196-200	LIF interleukin 6 family cytokine	Homo sapiens	54-57
3323675-6	1987	The importance of calcium to the metabolic effects of LIF was demonstrated by the abilities of the calmodulin inhibitor trifluoroperazine (51.5% inhibition) and the extracellular calcium chelator EGTA (50.5% inhibition) to suppress LIF-mediated degranulation.	Egtazic Acid	196-200	LIF interleukin 6 family cytokine	Homo sapiens	232-235
3040735-2	1987	Gelsolin binds to phosphatidylinositol 4,5-bisphosphate (PIP2), with consequent inhibition of its filament severing activity and dissociation of EGTA-resistant complexes made with rabbit macrophage or human plasma gelsolin and rabbit muscle actin.	Egtazic Acid	145-149	gelsolin	Oryctolagus cuniculus	0-8
3040735-4	1987	Both phosphoinositides completely dissociate EGTA-insensitive rabbit macrophage cytoplasmic gelsolin-actin complexes and inhibit gelsolin"s severing activity.	Egtazic Acid	45-49	gelsolin	Oryctolagus cuniculus	92-100
3040735-8	1987	PIP2 in combination with EGTA inactivates gelsolin molecules that block the fast-growing end of actin filaments, thereby accelerating actin polymerization.	Egtazic Acid	25-29	gelsolin	Oryctolagus cuniculus	42-50
3122761-1	1987	Tritiated calmodulin (T-CM) was bound to the EGTA-treated particulate fraction of cardiac muscle in a calcium-dependent manner with half-maximal binding occurring between 0.8 to 1.2 microM calcium.	Egtazic Acid	45-49	calmodulin 1	Homo sapiens	10-20
3680020-4	1987	On the other hand, basal activity (the activity in the presence of ethylene bis(oxyethylenenitrilo)tetraacetic acid (EGTA) instead of Ca2+/calmodulin) of the bovine brain enzyme, calmodulin-independent cyclic nucleotide phosphodiesterase from bovine heart, and protein kinase C from rat brain were inhibited by K-259-2 to a lesser extent with IC50 values of 27.4, 40.7 and 45.8 microM, respectively.	Egtazic Acid	67-115	calmodulin	Bos taurus	179-189
3117053-2	1987	Ca2+ chelation with EGTA restored impermeability to sucrose, which became entrapped in the matrix space.	Egtazic Acid	20-24	carbonic anhydrase 2	Rattus norvegicus	0-3
3117053-3	1987	t-Butylhydroperoxide markedly promoted permeabilization in the presence of Ca2+ but not in its absence, and Ca2+-plus-t-butylhydroperoxide-induced permeabilization was reversed by EGTA.	Egtazic Acid	180-184	carbonic anhydrase 2	Rattus norvegicus	108-111
3680022-4	1987	On the other hand, basal activity (the activity in the presence of ethylene bis(oxyethylenenitrilo)tetraacetic acid (EGTA) instead of Ca2+/calmodulin) of the bovine brain enzyme, calmodulin-independent cyclic nucleotide phosphodiesterase from bovine heart, and protein kinase C from rat brain were inhibited by KS-619-1 to a lesser extent with IC50 values; 12.3, 25.9 and 151 microM, respectively.	Egtazic Acid	117-121	calmodulin	Bos taurus	179-189
3113921-3	1987	In the presence of a calcium-chelating agent (EGTA, 20 mM) or a calcium-channel blocker (D-600, 0.1 mM), the release of GnRH induced by a depolarization (veratridine, 50 microM) was markedly and reversibly decreased.	Egtazic Acid	46-50	gonadotropin releasing hormone 1	Rattus norvegicus	120-124
2958483-2	1987	Myosin filaments in muscle homogenates maintained in relaxing conditions (ATP, EGTA) are found to have nonphosphorylated regulatory light chains as shown by urea/glycerol gel electrophoresis and [32P]phosphate autoradiography.	Egtazic Acid	79-83	myosin heavy chain 14	Homo sapiens	0-6
2956989-2	1987	ATP-driven Ca2+ transport in basolateral plasma membrane vesicles was inhibited by Cd2+ with an I50 value of 1.6 nM free Cd2+ at 1 microM free Ca2+, using EGTA and HEEDTA to buffer Ca2+ and Cd2+ concentrations, respectively.	Egtazic Acid	155-159	Cd2 molecule	Rattus norvegicus	83-86
3040771-5	1987	The calcium-dependent actin filament-severing activity of platelet extracts, a function of free gelsolin, fell in concert with the formation of EGTA-stable actin/gelsolin complexes, and rose when the adsorption experiments indicated that free gelsolin was restored.	Egtazic Acid	144-148	gelsolin	Homo sapiens	162-170
3040771-5	1987	The calcium-dependent actin filament-severing activity of platelet extracts, a function of free gelsolin, fell in concert with the formation of EGTA-stable actin/gelsolin complexes, and rose when the adsorption experiments indicated that free gelsolin was restored.	Egtazic Acid	144-148	gelsolin	Homo sapiens	162-170
3680020-4	1987	On the other hand, basal activity (the activity in the presence of ethylene bis(oxyethylenenitrilo)tetraacetic acid (EGTA) instead of Ca2+/calmodulin) of the bovine brain enzyme, calmodulin-independent cyclic nucleotide phosphodiesterase from bovine heart, and protein kinase C from rat brain were inhibited by K-259-2 to a lesser extent with IC50 values of 27.4, 40.7 and 45.8 microM, respectively.	Egtazic Acid	117-121	calmodulin	Bos taurus	179-189
3680022-4	1987	On the other hand, basal activity (the activity in the presence of ethylene bis(oxyethylenenitrilo)tetraacetic acid (EGTA) instead of Ca2+/calmodulin) of the bovine brain enzyme, calmodulin-independent cyclic nucleotide phosphodiesterase from bovine heart, and protein kinase C from rat brain were inhibited by KS-619-1 to a lesser extent with IC50 values; 12.3, 25.9 and 151 microM, respectively.	Egtazic Acid	67-115	calmodulin	Bos taurus	179-189
3298545-2	1987	These CaMDP activities bind to immobilized calmodulin in the presence of Ca2+ and are eluted by EGTA.	Egtazic Acid	96-100	calmodulin 1	Rattus norvegicus	43-53
3298545-10	1987	This cross-reacting protein was found among cellular proteins eluted from immobilized calmodulin by EGTA.	Egtazic Acid	100-104	calmodulin 1	Rattus norvegicus	86-96
3597392-9	1987	Specific elution of CaM-binding proteins from the CaM-Sepharose column with EGTA yielded a CaM-depleted adenylate cyclase fraction that was stimulated 2-fold by the addition of exogenous CaM.	Egtazic Acid	76-80	calmodulin-2	Equus caballus	20-23
3301497-2	1987	AMV-p35 can be readily purified from ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid extracts of the microfilament cores by chromatography on an anion exchange column, to which it does not bind.	Egtazic Acid	37-106	interleukin 12A	Homo sapiens	4-7
3038090-7	1987	The amount of specifically bound [3H]NT was significantly reduced in the presence of mono and divalent cations, EDTA, EGTA and a peptidase inhibitor bacitracin, NT1-13 competed with [3H]NT for its binding site with an IC50 of 0.19 nM at high affinity site (0.2 nM concentration of [3H]NT) and 0.7 nM at low affinity site (4.0 nM concentration of [3H]NT).	Egtazic Acid	118-122	neurotensin	Rattus norvegicus	37-39
3038090-7	1987	The amount of specifically bound [3H]NT was significantly reduced in the presence of mono and divalent cations, EDTA, EGTA and a peptidase inhibitor bacitracin, NT1-13 competed with [3H]NT for its binding site with an IC50 of 0.19 nM at high affinity site (0.2 nM concentration of [3H]NT) and 0.7 nM at low affinity site (4.0 nM concentration of [3H]NT).	Egtazic Acid	118-122	neurotensin	Rattus norvegicus	161-163
3038090-7	1987	The amount of specifically bound [3H]NT was significantly reduced in the presence of mono and divalent cations, EDTA, EGTA and a peptidase inhibitor bacitracin, NT1-13 competed with [3H]NT for its binding site with an IC50 of 0.19 nM at high affinity site (0.2 nM concentration of [3H]NT) and 0.7 nM at low affinity site (4.0 nM concentration of [3H]NT).	Egtazic Acid	118-122	neurotensin	Rattus norvegicus	161-163
3038090-7	1987	The amount of specifically bound [3H]NT was significantly reduced in the presence of mono and divalent cations, EDTA, EGTA and a peptidase inhibitor bacitracin, NT1-13 competed with [3H]NT for its binding site with an IC50 of 0.19 nM at high affinity site (0.2 nM concentration of [3H]NT) and 0.7 nM at low affinity site (4.0 nM concentration of [3H]NT).	Egtazic Acid	118-122	neurotensin	Rattus norvegicus	161-163
3656194-14	1987	However, removal of calcium ions from, and inclusion of 1 mM-EGTA in, the perfusion medium completely inhibited the secretion evoked by VIP.	Egtazic Acid	61-65	vasoactive intestinal peptide	Rattus norvegicus	136-139
3110148-3	1987	Thrombin induced these effects in the absence of extracellular calcium (EGTA) or in the presence of either 8-bromo-cAMP or the calmodulin inhibitor W7.	Egtazic Acid	72-76	coagulation factor II, thrombin	Homo sapiens	0-8
3597392-9	1987	Specific elution of CaM-binding proteins from the CaM-Sepharose column with EGTA yielded a CaM-depleted adenylate cyclase fraction that was stimulated 2-fold by the addition of exogenous CaM.	Egtazic Acid	76-80	calmodulin-2	Equus caballus	50-53
3597392-9	1987	Specific elution of CaM-binding proteins from the CaM-Sepharose column with EGTA yielded a CaM-depleted adenylate cyclase fraction that was stimulated 2-fold by the addition of exogenous CaM.	Egtazic Acid	76-80	calmodulin-2	Equus caballus	50-53
3597392-9	1987	Specific elution of CaM-binding proteins from the CaM-Sepharose column with EGTA yielded a CaM-depleted adenylate cyclase fraction that was stimulated 2-fold by the addition of exogenous CaM.	Egtazic Acid	76-80	calmodulin-2	Equus caballus	50-53
2438339-6	1987	This was in marked contrast to the finding that BSF-1-stimulated B cell responses which were suppressed after 24 hr of culture in the presence of EGTA could be restored by the addition of calcium.	Egtazic Acid	146-150	interleukin 4	Homo sapiens	48-53
3034434-6	1987	The anti-L3T4-insensitive increase in [Ca2+]i induced by Con A was inhibited by EGTA, suggesting that this mitogen also stimulated an influx of Ca2+ via an additional transport mechanism distinct from that stimulated by antigen.	Egtazic Acid	80-84	CD4 antigen	Mus musculus	9-13
2439084-7	1987	Phosphoinositidation of MBP was also detected when [32P] phosphoinositides were incubated with myelin pretreated with Triton X-100 and EGTA.	Egtazic Acid	135-139	myelin basic protein	Homo sapiens	24-27
2822296-5	1987	Addition of the calcium chelator EGTA (4 nM) to the perifusion medium induced a significant (P less than 0.01) decrease in both ACTH release rate (from 102.0 +/- 8.5 to 52.0 +/- 9.9 pg/2 min) and ACTH pulse amplitude (from 57.7 +/- 2.8 to 31.3 +/- 4.6 pg) (n = 3).	Egtazic Acid	33-37	proopiomelanocortin	Homo sapiens	128-132
3109498-1	1987	The calmodulin content of renal brush-border membrane vesicles, prepared by Mg2+-precipitation in EGTA-containing solutions, amounts to 1.8 micrograms per mg protein.	Egtazic Acid	98-102	calmodulin 1	Homo sapiens	4-14
2438163-5	1987	The fraction of soluble protein retained on calmodulin-Sepharose 4B columns in the presence of Ca2+ and eluted by EGTA is 0.7%.	Egtazic Acid	114-118	calmodulin-1	Sus scrofa	44-54
3112250-5	1987	Stimulation by angiotensin II was compared with the classical effect of the lectin phytohemagglutinin, and it was seen that both actions are mediated by external calcium (as they are blocked by EGTA 2.5 mM) and that the stimuli follow different kinetics, reaching the steady state at 6 h with angiotensin II and later (18 h) when the lectin was used.	Egtazic Acid	194-198	angiotensinogen	Homo sapiens	15-29
3107572-3	1987	Moreover, the PTZ-stimulated synapsin I phosphorylation was reversed by addition of EGTA sufficient to chelate all external free Ca2+.	Egtazic Acid	84-88	synapsin I	Rattus norvegicus	29-39
2439377-4	1987	When 3 mM EGTA was present in the culture medium, the inhibitory effect of EGF was abolished but the stimulatory effect of FSH or dcAMP was magnified.	Egtazic Acid	10-14	epidermal growth factor like 1	Rattus norvegicus	75-78
2822296-5	1987	Addition of the calcium chelator EGTA (4 nM) to the perifusion medium induced a significant (P less than 0.01) decrease in both ACTH release rate (from 102.0 +/- 8.5 to 52.0 +/- 9.9 pg/2 min) and ACTH pulse amplitude (from 57.7 +/- 2.8 to 31.3 +/- 4.6 pg) (n = 3).	Egtazic Acid	33-37	proopiomelanocortin	Homo sapiens	196-200
3106489-7	1987	CD5-induced calcium mobilization was found to differ from CD3 stimulation in that EGTA entirely ablated the CD5 response, whereas the CD3 response was resistant to EGTA, indicating that the CD5-induced increased [Ca2+]i is derived primarily or entirely from extracellular calcium.	Egtazic Acid	82-86	CD5 molecule	Homo sapiens	0-3
2436894-8	1987	Basal (1 h) and CRF-stimulated (5 min) ACTH release were also inhibited in medium containing 1 mM EGTA and no Ca2+; however, percentages of CRF-bound cells were within the normal range.	Egtazic Acid	98-102	proopiomelanocortin	Homo sapiens	39-43
2436894-9	1987	Densitometric analysis of stains for ACTH showed an increase in the concentration of stain per cell after a 1-h exposure to the highest concentrations of the inhibitors or to no Ca2+ and 1 mM EGTA coupled with a significant (10%) decrease in corticotrope cell area.	Egtazic Acid	192-196	proopiomelanocortin	Homo sapiens	37-41
3569665-13	1987	Calmodulin injections did result in significant cases of maturation when oocytes were first pretreated (primed) with calcium-free (EGTA) OR-2 and then injected in regular OR-2 medium.	Egtazic Acid	131-135	calmodulin 1	Homo sapiens	0-10
3106489-7	1987	CD5-induced calcium mobilization was found to differ from CD3 stimulation in that EGTA entirely ablated the CD5 response, whereas the CD3 response was resistant to EGTA, indicating that the CD5-induced increased [Ca2+]i is derived primarily or entirely from extracellular calcium.	Egtazic Acid	82-86	CD5 molecule	Homo sapiens	108-111
3106489-7	1987	CD5-induced calcium mobilization was found to differ from CD3 stimulation in that EGTA entirely ablated the CD5 response, whereas the CD3 response was resistant to EGTA, indicating that the CD5-induced increased [Ca2+]i is derived primarily or entirely from extracellular calcium.	Egtazic Acid	82-86	CD5 molecule	Homo sapiens	108-111
3031213-6	1987	In a calcium-free buffer containing EGTA, the NGF-dependent increase in accumulation of [3H]IP was not seen, and the basal level of [3H]IP accumulation was lower than that observed in the presence of extracellular calcium.	Egtazic Acid	36-40	nerve growth factor	Rattus norvegicus	46-49
3028803-1	1987	Vasopressin and angiotensin II inhibited in a dose-dependent fashion the stimulation of ureagenesis induced by alpha 1-adrenergic activation in hepatocytes incubated in medium without calcium and containing 25 microM EGTA.	Egtazic Acid	217-221	arginine vasopressin	Homo sapiens	0-11
3030755-2	1987	In postribosomal extracts of these cells, prepared in the presence of glycerol 2-phosphate and EGTA, a ribosomal protein S6 kinase was detected.	Egtazic Acid	95-99	40S ribosomal protein S6	Mesocricetus auratus	103-123
2820385-15	1987	The Ca2+-calmodulin-sensitive phosphodiesterase from the DEAE-Sephacel column can be adsorbed to a calmodulin-Sepharose affinity column and eluted with EGTA.	Egtazic Acid	152-156	calmodulin 1	Homo sapiens	9-19
2820385-15	1987	The Ca2+-calmodulin-sensitive phosphodiesterase from the DEAE-Sephacel column can be adsorbed to a calmodulin-Sepharose affinity column and eluted with EGTA.	Egtazic Acid	152-156	calmodulin 1	Homo sapiens	99-109
3108130-7	1987	The cytosolic ATP citrate lyase activity increase with CT administration was completely blocked by treatment of cytosol with EGTA (10 microM).	Egtazic Acid	125-129	ATP citrate lyase	Rattus norvegicus	14-31
3108130-7	1987	The cytosolic ATP citrate lyase activity increase with CT administration was completely blocked by treatment of cytosol with EGTA (10 microM).	Egtazic Acid	125-129	calcitonin-related polypeptide alpha	Rattus norvegicus	55-57
3102484-4	1987	In order to examine whether the metal ion chelators EDTA or EGTA affect the cation binding equilbria by binding to bovine alpha-lactalbumin, calcium binding equilibria were carefully measured under highly stabilized pH and temperature conditions.	Egtazic Acid	60-64	lactalbumin alpha	Bos taurus	122-139
3102480-5	1987	EGF and bradykinin also produced a rapid, although transient, 3- and 5-fold increase, respectively, in cytosolic free Ca2+ after chelation of extracellular Ca2+ with 3 mM EGTA.	Egtazic Acid	171-175	epidermal growth factor	Homo sapiens	0-3
3028803-1	1987	Vasopressin and angiotensin II inhibited in a dose-dependent fashion the stimulation of ureagenesis induced by alpha 1-adrenergic activation in hepatocytes incubated in medium without calcium and containing 25 microM EGTA.	Egtazic Acid	217-221	angiotensinogen	Homo sapiens	16-30
3102480-5	1987	EGF and bradykinin also produced a rapid, although transient, 3- and 5-fold increase, respectively, in cytosolic free Ca2+ after chelation of extracellular Ca2+ with 3 mM EGTA.	Egtazic Acid	171-175	kininogen 1	Homo sapiens	8-18
3660070-5	1987	The adherence was greatly diminished by EGTA treated normal human serum (NHS) and was completely abolished when NHS was treated with either EDTA or heat-inactivation, suggesting that the process can be facilitated through complement activation via the alternative pathway.	Egtazic Acid	40-44	NHS actin remodeling regulator	Homo sapiens	73-76
3597341-2	1987	This protein was retained on an actin-DNase I affinity column only in the presence of Ca2+, and could be eluted from this column by EGTA.	Egtazic Acid	132-136	deoxyribonuclease 1	Bos taurus	38-45
3031646-10	1987	In the presence of 1 mM EGTA, gustin activated cAMP PDE 5- to 6-fold, but the activating ability was completely lost after gustin was heated at 100 degrees C for 5 min.	Egtazic Acid	24-28	carbonic anhydrase 6	Homo sapiens	30-36
3031646-11	1987	In contrast, calmodulin lost all activating ability in the presence of 1 mM EGTA, whereas heating calmodulin at 100 degrees C for 5 min did not affect its activation of cAMP PDEase.	Egtazic Acid	76-80	calmodulin 1	Homo sapiens	13-23
3308931-11	1987	The vesicular calmodulin was not eluted by washing with 5 mM-EGTA.	Egtazic Acid	61-65	calmodulin 1	Homo sapiens	14-24
3660070-5	1987	The adherence was greatly diminished by EGTA treated normal human serum (NHS) and was completely abolished when NHS was treated with either EDTA or heat-inactivation, suggesting that the process can be facilitated through complement activation via the alternative pathway.	Egtazic Acid	40-44	NHS actin remodeling regulator	Homo sapiens	112-115
2457798-7	1987	Cells were desensitized with GnRH in the presence of 3 mM EGTA.	Egtazic Acid	58-62	gonadotropin releasing hormone 1	Homo sapiens	29-33
3593228-7	1987	Calmodulin migrated more slowly in the presence of Sr2+ than it did in the presence of EGTA but faster than it did in the presence of Ca2+ on polyacrylamide-gel electrophoresis under non-denaturing conditions.	Egtazic Acid	87-91	calmodulin 1	Homo sapiens	0-10
3034280-3	1987	Further, the activity of the enzyme is stimulated over two fold by Ca++ and calmodulin and inhibited by EGTA, a Ca++ chelator and trifluoperazine, an anti-calmodulin compound.	Egtazic Acid	104-108	calmodulin 1	Rattus norvegicus	76-86
3034280-3	1987	Further, the activity of the enzyme is stimulated over two fold by Ca++ and calmodulin and inhibited by EGTA, a Ca++ chelator and trifluoperazine, an anti-calmodulin compound.	Egtazic Acid	104-108	calmodulin 1	Rattus norvegicus	155-165
3542505-5	1987	A rapid increase (first phase) in [Ca2+]i induced by GnRH was observed in Ca2+-free medium containing EGTA, but this rapid phase was terminated within 2 min.	Egtazic Acid	102-106	gonadotropin releasing hormone 1	Rattus norvegicus	53-57
3109377-5	1987	The effect of ionophore on the deacetylation of PAF-acether was parallel with the increase of [Ca2+]i and could be reversed by the addition of EGTA.	Egtazic Acid	143-147	carbonic anhydrase 2	Oryctolagus cuniculus	95-98
3025333-7	1987	Therefore, our results suggest that macrophages possess a mechanism, not directly involving Ca2+, for dissociating actin/gelsolin EGTA-resistant complexes.	Egtazic Acid	130-134	gelsolin	Homo sapiens	121-129
3101593-11	1987	In the course of this work, it was found that Lys 94 in apocalmodulin is specifically perturbed by the addition of EGTA, suggesting that the chelating agent may interact with calmodulin at or near the third Ca2+-binding domain.	Egtazic Acid	115-119	calmodulin 1	Homo sapiens	59-69
3023028-10	1987	While a significant degree of desensitization also occurred in the presence of 3 mM EGTA (conditions that totally inhibited GnRH-stimulated LH release), the loss of responsiveness was not as great as in the absence of EGTA, indicating that partial depletion of available LH may play a role in GnRH-stimulated gonadotrope desensitization.	Egtazic Acid	84-88	gonadotropin releasing hormone 1	Homo sapiens	124-128
3025333-2	1987	We have developed an immunoadsorption technique for quantitating EGTA-resistant gelsolin/actin complexes in macrophages extracted with Triton X-100.	Egtazic Acid	65-69	gelsolin	Homo sapiens	80-88
3113177-2	1987	Substances acting on the intracellular Ca2+ level of the Tetrahymena, such as TMB-8, EDTA, EGTA, NiCl2 and La(NO3)3, interfered with hormonal imprinting of the unicellular to different degrees, and some of them influenced hormone (insulin, TSH) binding also independently of imprinting.	Egtazic Acid	91-95	insulin	Homo sapiens	231-238
11539029-9	1987	Preloading of the root tips with 32P in the presence of EGTA and A-23187 followed by a ten minute calcium treatment, resulted in increased phosphorylation indicating the involvement of calcium, calcium and calmodulin-dependent kinases.	Egtazic Acid	56-60	calmodulin1	Zea mays	206-216
2822934-7	1987	Sixty to 90% of Cai could be removed by incubation of the cells with A23187 and EGTA.	Egtazic Acid	80-84	carbonic anhydrase 1	Homo sapiens	16-19
3025333-5	1987	On the other hand, exposure of suspended cells to the chemotactic oligopeptide, FMLP, or plating of the cells onto tissue culture dishes causes the EGTA-resistant complex to dissociate rapidly.	Egtazic Acid	148-152	formyl peptide receptor 1	Homo sapiens	80-84
3782465-6	1986	Further, AII and AVP caused cell contraction and membrane depolarization in Ca++-free medium containing 0.5 mM EGTA.	Egtazic Acid	111-115	angiotensinogen	Rattus norvegicus	9-12
3789156-9	1986	Treatment of cells with angiotensin II in ethyleneglycol-bis-(beta-aminoethylether)-N,N"-tetraacetic acid-supplemented Ca-deficient medium, or with the Ca channel blockers nifedipine or verapamil, did not eliminate the transient phase of cytosolic Ca metabolism.	Egtazic Acid	42-105	angiotensinogen	Homo sapiens	24-38
2429967-3	1986	When gel-filtered platelets are incubated with 0.25 mM EGTA at 37 degrees C for 30 min, and then supplemented for 30 min with 5 mM calcium, they lose their ability to bind GP IIb-IIIa complex-specific monoclonal antibody Fab fragments.	Egtazic Acid	55-59	integrin subunit alpha 2b	Homo sapiens	172-178
3023089-2	1986	Over 90% of the gelsolin bound to F-actin in 0.1 mM CaCl2 in experiments using 24 microM actin and 2-10 nM 125I-gelsolin, but only 40-50% bound in 1 mM EGTA.	Egtazic Acid	152-156	GSN	Sus scrofa	16-24
3023089-5	1986	F-actin prepared from G-actin in calcium or pretreated with calcium, binds 125I-gelsolin more completely in EGTA.	Egtazic Acid	108-112	GSN	Sus scrofa	80-88
3023089-8	1986	The gelsolin present in the EGTA supernatant is complexed to G-actin, predominantly as binary complexes.	Egtazic Acid	28-32	GSN	Sus scrofa	4-12
2429967-3	1986	When gel-filtered platelets are incubated with 0.25 mM EGTA at 37 degrees C for 30 min, and then supplemented for 30 min with 5 mM calcium, they lose their ability to bind GP IIb-IIIa complex-specific monoclonal antibody Fab fragments.	Egtazic Acid	55-59	FA complementation group B	Homo sapiens	221-224
2429967-6	1986	In immunofluorescence experiments, we have found that EGTA-incubated platelets contain a large sequestered internal pool of GP IIb-IIIa which upon thrombin stimulation is translocated to the platelet surface.	Egtazic Acid	54-58	integrin subunit alpha 2b	Homo sapiens	124-130
2429967-6	1986	In immunofluorescence experiments, we have found that EGTA-incubated platelets contain a large sequestered internal pool of GP IIb-IIIa which upon thrombin stimulation is translocated to the platelet surface.	Egtazic Acid	54-58	coagulation factor II, thrombin	Homo sapiens	147-155
3771533-2	1986	The mechanism of association of the human platelet membrane GPIIb-GPIIIa-Ca2+ complex was studied by treating solubilized membranes with various enzymes and cationic peptides and by studying the binding of 45Ca2+ and 125I-fibrinogen before and after dissociation with EGTA and association with Ca2+.	Egtazic Acid	268-272	integrin subunit alpha 2b	Homo sapiens	60-65
3021730-2	1986	A rabbit lung cyclic nucleotide phosphodiesterase (PDE) prepared by successive chromatography on DEAE-cellulose and G-200 Sephadex columns in the presence of EGTA was activated by Ca2+ and contained calmodulin (CaM), suggesting that the enzyme exists as a stable CaM X PDE complex (Sharma, R. K., and Wirch, E. (1979) Biochem.	Egtazic Acid	158-162	calmodulin	Oryctolagus cuniculus	199-209
3021730-2	1986	A rabbit lung cyclic nucleotide phosphodiesterase (PDE) prepared by successive chromatography on DEAE-cellulose and G-200 Sephadex columns in the presence of EGTA was activated by Ca2+ and contained calmodulin (CaM), suggesting that the enzyme exists as a stable CaM X PDE complex (Sharma, R. K., and Wirch, E. (1979) Biochem.	Egtazic Acid	158-162	calmodulin	Oryctolagus cuniculus	211-214
3021730-2	1986	A rabbit lung cyclic nucleotide phosphodiesterase (PDE) prepared by successive chromatography on DEAE-cellulose and G-200 Sephadex columns in the presence of EGTA was activated by Ca2+ and contained calmodulin (CaM), suggesting that the enzyme exists as a stable CaM X PDE complex (Sharma, R. K., and Wirch, E. (1979) Biochem.	Egtazic Acid	158-162	calmodulin	Oryctolagus cuniculus	263-266
3021730-14	1986	The purified enzyme could be reconstituted into a PDE X CaM complex upon incubation with CaM in the presence of either Ca2+ or EGTA.	Egtazic Acid	127-131	calmodulin	Bos taurus	56-59
3021730-14	1986	The purified enzyme could be reconstituted into a PDE X CaM complex upon incubation with CaM in the presence of either Ca2+ or EGTA.	Egtazic Acid	127-131	calmodulin	Bos taurus	89-92
3771533-2	1986	The mechanism of association of the human platelet membrane GPIIb-GPIIIa-Ca2+ complex was studied by treating solubilized membranes with various enzymes and cationic peptides and by studying the binding of 45Ca2+ and 125I-fibrinogen before and after dissociation with EGTA and association with Ca2+.	Egtazic Acid	268-272	integrin subunit beta 3	Homo sapiens	66-72
3771533-4	1986	The EGTA-dissociated complex was almost completely reassociated with neuraminidase or the cationic peptide, tetralysine.	Egtazic Acid	4-8	neuraminidase 1	Homo sapiens	69-82
3771533-7	1986	Neuraminidase treatment of washed intact platelets resulted in a cathodal shift of the membrane Triton X-100-extracted associated complex with no effect on its ability to dissociate in the presence of EGTA.	Egtazic Acid	201-205	neuraminidase 1	Homo sapiens	0-13
3771533-8	1986	Neuraminidase treatment of ADP-perturbed washed platelets also resulted in a cathodal shift of the associated complex; however, dissociation with EGTA was inhibited.	Egtazic Acid	146-150	neuraminidase 1	Homo sapiens	0-13
3021456-7	1986	The gelsolin-actin complex was found to bind fourfold faster to the barbed ends in the presence of Ca2+ (10 X 10(6) M-1 s-1) than in excess EGTA (2.5 X 10(6) M-1 s-1).	Egtazic Acid	140-144	gelsolin	Homo sapiens	4-12
3771533-12	1986	125I-fibrinogen bound to the associated complex (not the dissociated complex), to the Ca2+-reassociated complex, and to the neuraminidase-reassociated complex which had been dissociated with EGTA.	Egtazic Acid	191-195	fibrinogen beta chain	Homo sapiens	5-15
3095334-4	1986	Addition of Ca2+ to EGTA-treated cells results in the recovery of cell-cell junctions including the reorganization of adherens junction-specific cell adhesion molecule (A-CAM), vinculin, and actin (Volk, T., and B. Geiger, 1986, J.	Egtazic Acid	20-24	CXADR like membrane protein	Homo sapiens	169-174
3018031-6	1986	The addition of EGTA to the medium inhibited ACTH- and forskolin-stimulated DS, F, and cAMP secretion by 50% as well as (Bu)2cAMP-stimulated steroidogenesis.	Egtazic Acid	16-20	proopiomelanocortin	Homo sapiens	45-49
3095334-4	1986	Addition of Ca2+ to EGTA-treated cells results in the recovery of cell-cell junctions including the reorganization of adherens junction-specific cell adhesion molecule (A-CAM), vinculin, and actin (Volk, T., and B. Geiger, 1986, J.	Egtazic Acid	20-24	vinculin	Homo sapiens	177-185
3550047-7	1986	In zero Ca2+ buffers containing EGTA (5 mM), secretion of both active and inactive renin was increased but these changes were abolished by addition of ouabain (100 microM).	Egtazic Acid	32-36	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	83-88
3025253-3	1986	Fully dephosphorylated myosin is obtained by dialysis of muscle crude extract (0.06 M NaCl, 0.01 M Tris-HCl, pH 7.5, 50 microM EGTA); fully phosphorylated myosin is obtained by addition of Ca2+ (0.2 mM), Mg2+ (10 mM) and ATP (3 mM) and 5 min incubation at 28 degrees C. The following reaction characteristics were noted.	Egtazic Acid	127-131	myosin heavy chain 14	Homo sapiens	23-29
2874832-2	1986	The inhibitory action of calmodulin on the calcium-dependent enzyme reactions was analogous to the effects of EGTA and parvalbumin on these reactions.	Egtazic Acid	110-114	calmodulin 1	Homo sapiens	25-35
3091496-4	1986	The rate of decline in responsiveness to FMLP is greatly accelerated when neutrophils incubated in the presence of A23187 and Ca2+-free medium, while the rate of loss of responsiveness to FMLP is not affected by EGTA but the extent of loss is increased.	Egtazic Acid	212-216	formyl peptide receptor 1	Homo sapiens	41-45
3542105-6	1986	Ethylenediamine tetra-acetic acid (EDTA) and ethyleneglycol-bis-(beta-amino-ethyl ether) N,N"-tetra-acetic acid (EGTA) increased renin secretion to a similar degree in Ca2+- and Mg2+-free buffer.	Egtazic Acid	113-117	renin	Rattus norvegicus	129-134
3091496-4	1986	The rate of decline in responsiveness to FMLP is greatly accelerated when neutrophils incubated in the presence of A23187 and Ca2+-free medium, while the rate of loss of responsiveness to FMLP is not affected by EGTA but the extent of loss is increased.	Egtazic Acid	212-216	formyl peptide receptor 1	Homo sapiens	188-192
3015910-3	1986	ACTH action is greatly inhibited but not abolished by removal of extracellular calcium and is completely blocked in medium containing no added calcium and 1 mM EGTA.	Egtazic Acid	160-164	proopiomelanocortin	Homo sapiens	0-4
2874192-3	1986	The enhancement of isoproterenol-stimulated cAMP production by alpha-adrenergic and gamma-aminobutyric acid-B (GABAB) agonists was reduced by exposing the tissue to EGTA, a chelator of divalent cations, or quinacrine, a nonselective inhibitor of phospholipase A2.	Egtazic Acid	165-169	phospholipase A2 group IB	Rattus norvegicus	246-262
2943164-7	1986	Incubation of platelets with EGTA at 37 C abolished staining of plasma membrane and vacuolar but not alpha-granule GPIIb/IIIa.	Egtazic Acid	29-33	integrin subunit alpha 2b	Homo sapiens	115-120
2881817-2	1987	When testis tissue was homogenized in the presence of 2 mmol/l EDTA and EGTA, the majority (greater than 70%) of the PK-C activity was soluble, the rest was released from the particulate fraction by solubilization with 0.3% Triton X-100.	Egtazic Acid	72-76	protein kinase C, gamma	Rattus norvegicus	117-121
3733874-7	1986	In the presence of 5 mM EGTA, PAF raised [Ca2+]i by 25 nM.	Egtazic Acid	24-28	patchy fur	Mus musculus	30-33
3087980-0	1986	Innocuous character of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid and EDTA as metal-ion buffers in studying Ca2+ binding by alpha-lactalbumin.	Egtazic Acid	24-72	lactalbumin alpha	Homo sapiens	131-148
3087980-1	1986	The binding of EGTA and EDTA to alpha-lactalbumin, first demonstrated by Kronman and Bratcher (Kronman, M. J., and Bratcher, S. C. (1983) J. Biol.	Egtazic Acid	15-19	lactalbumin alpha	Homo sapiens	32-49
3015137-2	1986	Superoxide anion generation was provoked at TNF concentration of 1 X 10(-11) M and maximal generation was attained at TNF concentration of 1 X 10(-9) M. We also show that movements of intracellular calcium may mediate the TNF-stimulated superoxide anion generation because 8-(diethylamino) octyl 3,4,5-trimethoxybenzoate hydrochloride--but not extracellular EGTA--inhibited the generation of superoxide anion.	Egtazic Acid	358-362	tumor necrosis factor	Homo sapiens	118-121
3015137-2	1986	Superoxide anion generation was provoked at TNF concentration of 1 X 10(-11) M and maximal generation was attained at TNF concentration of 1 X 10(-9) M. We also show that movements of intracellular calcium may mediate the TNF-stimulated superoxide anion generation because 8-(diethylamino) octyl 3,4,5-trimethoxybenzoate hydrochloride--but not extracellular EGTA--inhibited the generation of superoxide anion.	Egtazic Acid	358-362	tumor necrosis factor	Homo sapiens	118-121
3755042-4	1986	In the absence of external Ca2+, with 1 mM EGTA, the measured delays were 300 +/- 20 msec for thrombin and 210 +/- 10 msec for ADP.	Egtazic Acid	43-47	coagulation factor II, thrombin	Homo sapiens	94-102
3087287-4	1986	Similarly, chelation of extracellular calcium by ethyleneglycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA) prevented ODC induction by TPA, which could be resumed upon calcium restoration in the medium.	Egtazic Acid	49-112	ornithine decarboxylase, structural 1	Mus musculus	130-133
3087287-4	1986	Similarly, chelation of extracellular calcium by ethyleneglycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA) prevented ODC induction by TPA, which could be resumed upon calcium restoration in the medium.	Egtazic Acid	114-118	ornithine decarboxylase, structural 1	Mus musculus	130-133
3087287-7	1986	Inhibition of the induction of ODC activity by EGTA was the result of the inhibition of the amount of active ODC protein and the level of ODC mRNA.	Egtazic Acid	47-51	ornithine decarboxylase, structural 1	Mus musculus	31-34
3087287-7	1986	Inhibition of the induction of ODC activity by EGTA was the result of the inhibition of the amount of active ODC protein and the level of ODC mRNA.	Egtazic Acid	47-51	ornithine decarboxylase, structural 1	Mus musculus	109-112
3087287-7	1986	Inhibition of the induction of ODC activity by EGTA was the result of the inhibition of the amount of active ODC protein and the level of ODC mRNA.	Egtazic Acid	47-51	ornithine decarboxylase, structural 1	Mus musculus	109-112
2938630-4	1986	The subsequent addition of EGTA and ADP induced triphasic EP dephosphorylation.	Egtazic Acid	27-31	prostaglandin E receptor 1	Homo sapiens	58-60
2422345-7	1986	The A23187-mediated decrease in ATP levels and the reduced [3H]AdoMet formation was antagonized by ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid and MnCl2.	Egtazic Acid	99-163	methionine adenosyltransferase 1A	Rattus norvegicus	63-69
3010732-6	1986	The calcium inhibitors, verapamil, EGTA, and CoCl2, markedly suppressed basal GH release and virtually completely blocked the GH response to TRH, suggesting calcium mediation.	Egtazic Acid	35-39	gonadotropin releasing hormone receptor	Rattus norvegicus	78-80
3010732-6	1986	The calcium inhibitors, verapamil, EGTA, and CoCl2, markedly suppressed basal GH release and virtually completely blocked the GH response to TRH, suggesting calcium mediation.	Egtazic Acid	35-39	gonadotropin releasing hormone receptor	Rattus norvegicus	126-128
3010732-6	1986	The calcium inhibitors, verapamil, EGTA, and CoCl2, markedly suppressed basal GH release and virtually completely blocked the GH response to TRH, suggesting calcium mediation.	Egtazic Acid	35-39	thyrotropin releasing hormone	Rattus norvegicus	141-144
3084500-1	1986	EGTA-induced depletion of Ca2+ ions from the culture medium of Madin-Darby bovine kidney epithelial cells results in rapid splitting of adherens-type junctions and the detachment of the vinculin- and actin-containing filament bundle from the cytoplasmic faces of the plasma membrane of the zonula adhaerens.	Egtazic Acid	0-4	vinculin	Bos taurus	186-194
2422345-3	1986	The calcium ionophore A23187 and ouabain decreased PCM activity and the decrease produced by A23187 was antagonized by ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid and MnCl2.	Egtazic Acid	119-183	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Rattus norvegicus	51-54
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	33-101	calmodulin 2	Mus musculus	189-199
2939833-3	1986	The release of ANF was increased by addition of 50 mM KCl and the release by 50 mM KCl was completely suppressed in the presence of 2 mM EGTA, a chelating agent of Ca2+.	Egtazic Acid	137-141	natriuretic peptide A	Rattus norvegicus	15-18
3085668-1	1986	Addition of NaF to washed platelets produces a dose-dependent and transient elevation of the intracellular free calcium concentration ([Ca++]i), thromboxane B2 (TxB2) generation and dense granule release, all of which are significantly inhibited when the extracellular calcium concentration ([Ca++]e) is reduced with EGTA.	Egtazic Acid	317-321	C-X-C motif chemokine ligand 8	Homo sapiens	12-15
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	33-101	calmodulin 2	Mus musculus	156-166
3022252-3	1986	EGTA at 3 mM decreased the amount of CRF stimulated ACTH release by 60% but did not alter the spontaneous release of ACTH.	Egtazic Acid	0-4	proopiomelanocortin	Homo sapiens	52-56
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	103-107	calmodulin 2	Mus musculus	156-166
3083690-6	1986	Preparation of membranes in 2 mM ethyleneglycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacet ic acid (EGTA) resulted not only in a significant decrease in calmodulin levels (0.5 microgram calmodulin/mg protein) but also in a loss of the ability of Ca2+ to stimulate the enzyme.	Egtazic Acid	103-107	calmodulin 2	Mus musculus	189-199
3083690-7	1986	Exogenous calmodulin restored the ability of Ca2+ to stimulate the adenylate cyclase activity associated with EGTA-treated membranes.	Egtazic Acid	110-114	calmodulin 2	Mus musculus	10-20
2420199-5	1986	The deletion of calcium and addition of EGTA into the incubation medium significantly attenuated the secretion of kallikrein and tonin induced by NE.	Egtazic Acid	40-44	kallikrein 1-related peptidase C2	Rattus norvegicus	129-134
2420827-7	1986	Both the CD2 and CD3 responses were diminished in magnitude and duration by EGTA.	Egtazic Acid	76-80	CD2 molecule	Homo sapiens	9-12
3011651-3	1986	This process in both NHS and EGTA-NHS was accompanied by the consumption of C2, C4, C3, and factor B but only by poor enhancement of C5 conversion.	Egtazic Acid	29-33	complement C3	Homo sapiens	84-100
3949008-4	1986	Both EGTA, which abolished the latter and creatine phosphate/creatine phosphokinase, the ADP scavenger, totally inhibited the aggregation but only partially reduced [14C]5HT secretion in response to thrombin plus OAG.	Egtazic Acid	5-9	coagulation factor II, thrombin	Homo sapiens	199-207
3081576-8	1986	[Cai2+] response to A23187 and thrombin was reduced by addition of EGTA to platelets loaded with either aequorin or quin2.	Egtazic Acid	67-71	coagulation factor II, thrombin	Homo sapiens	31-39
3511851-5	1986	The stimulated S6 kinase activity requires ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid to be present during the kinase assay for full expression.	Egtazic Acid	43-112	ribosomal protein S6 kinase B1	Rattus norvegicus	15-24
3080021-5	1986	Addition of calmodulin to transverse tubule vesicles--treated with high salt in the presence of EGTA to remove endogenous calmodulin--caused a marked stimulation of transport rates at low concentrations of calcium, and decreased from 1.0 to 0.3 microM the calcium concentration at which half-maximal rates of transport were obtained.	Egtazic Acid	96-100	calmodulin	Oryctolagus cuniculus	12-22
3079818-1	1986	The Ca2+ and calmodulin sensitivity of endogenous protein kinase activity in synaptosomal membrane fragments from rat brain was studied in medium containing Ca2+ plus EGTA using a modified computer programme to calculate free Ca2+ concentrations that took into account the effect of all competing cations and chelators.	Egtazic Acid	167-171	calmodulin 1	Rattus norvegicus	13-23
3080021-5	1986	Addition of calmodulin to transverse tubule vesicles--treated with high salt in the presence of EGTA to remove endogenous calmodulin--caused a marked stimulation of transport rates at low concentrations of calcium, and decreased from 1.0 to 0.3 microM the calcium concentration at which half-maximal rates of transport were obtained.	Egtazic Acid	96-100	calmodulin	Oryctolagus cuniculus	122-132
3011154-4	1986	This calmodulin stimulation of Ca2+ transport does not require pretreatment of the membranes by EGTA and is an intrinsic property of the plasma membranes.	Egtazic Acid	96-100	calmodulin-2	Canis lupus familiaris	5-15
3002792-3	1986	Complex formation has been studied by high-performance gel permeation chromatography; plasma gelsolin alone elutes at an Mr of about 77000 and a Stokes radius of 3.7 nm; complex formation occurs in the presence of Ca2+: by chromatography in the presence of EGTA, a binary complex is obtained with an Mr of 134000 and a Stokes radius of 4.7 nm; and by chromatography in the presence of Ca2+, a ternary complex is obtained with an Mr of 173000 and a Stokes radius of 5.2 nm.	Egtazic Acid	257-261	gelsolin	Homo sapiens	93-101
2416747-0	1986	Rapid and extensive release of Ca2+ from energized mitochondria induced by EGTA.	Egtazic Acid	75-79	carbonic anhydrase 2	Rattus norvegicus	31-34
2416747-3	1986	The size of the released fraction is an apparent function of the extramitochondrial Ca2+ concentration at the time of EGTA addition and can attain a maximal value of approximately 30 nmol/mg protein.	Egtazic Acid	118-122	carbonic anhydrase 2	Rattus norvegicus	84-87
3001099-13	1986	Elution with 4 mM EGTA released material that gel filtration showed to be the EGTA-stable 130,000-mol-wt gelsolin-actin complex, GA1Ca1.	Egtazic Acid	18-22	gelsolin	Homo sapiens	105-113
2933269-2	1986	Recent studies by Gerke & Weber [14] have shown that p36 can be isolated from intestine by selective extraction with the Ca2+-chelating agent EGTA.	Egtazic Acid	146-150	5'-nucleotidase, cytosolic IIIA	Homo sapiens	57-60
3081414-4	1986	The increased cytosolic ATP citrate lyase activity resulting from CT administration was prevented by treatment with 10 microM EGTA.	Egtazic Acid	126-130	ATP citrate lyase	Rattus norvegicus	24-41
3081414-4	1986	The increased cytosolic ATP citrate lyase activity resulting from CT administration was prevented by treatment with 10 microM EGTA.	Egtazic Acid	126-130	calcitonin-related polypeptide alpha	Rattus norvegicus	66-68
3001099-19	1986	Similarly, preformed brevin-actin-Ca2+ complex, equilibrated with EGTA, was retained by 4F8 IgA-Sepharose.	Egtazic Acid	66-70	gelsolin	Homo sapiens	21-27
3001099-13	1986	Elution with 4 mM EGTA released material that gel filtration showed to be the EGTA-stable 130,000-mol-wt gelsolin-actin complex, GA1Ca1.	Egtazic Acid	78-82	gelsolin	Homo sapiens	105-113
3001100-11	1986	Brevin binding occurs in either Ca2+ or EGTA, but is slightly more intense in EGTA suggesting some severing and filament removal may occur in Ca2+.	Egtazic Acid	40-44	gelsolin	Homo sapiens	0-6
3001100-11	1986	Brevin binding occurs in either Ca2+ or EGTA, but is slightly more intense in EGTA suggesting some severing and filament removal may occur in Ca2+.	Egtazic Acid	78-82	gelsolin	Homo sapiens	0-6
2952866-7	1986	Activation of isolated Ca2+-ATPase in the presence of 0.1 mM EGTA results in PCB- release into the medium and additional TPP+ binding to the enzyme.	Egtazic Acid	61-65	pyruvate carboxylase	Homo sapiens	77-80
3079907-7	1986	As with pp35, EGF(Uro)-stimulated phosphorylation of isolated rabbit liver beta-35 was observed in a reconstituted system using either EDTA/EGTA-washed placental membranes or solubilized EGF(Uro) receptor immobilized on concanavalin A-agarose.	Egtazic Acid	140-144	epidermal growth factor	Homo sapiens	14-22
4076176-7	1985	Limited tryptic and chymotryptic digestion of brevin distinguishes the Ca2+-induced conformation from the EGTA one.	Egtazic Acid	106-110	gelsolin	Bos taurus	46-52
3079907-5	1986	Either in its native or in its phosphorylated form, pp35 could be released from the membranes in the presence of calcium-chelating agents (EDTA/EGTA); and EGF(Uro)-stimulated phosphorylation was reconstituted by adding back EDTA/EGTA eluates to EDTA/EGTA-washed membranes in the presence of calcium.	Egtazic Acid	144-148	dihydrouridine synthase 4 like	Homo sapiens	52-56
3079907-5	1986	Either in its native or in its phosphorylated form, pp35 could be released from the membranes in the presence of calcium-chelating agents (EDTA/EGTA); and EGF(Uro)-stimulated phosphorylation was reconstituted by adding back EDTA/EGTA eluates to EDTA/EGTA-washed membranes in the presence of calcium.	Egtazic Acid	144-148	epidermal growth factor	Homo sapiens	155-163
3079907-5	1986	Either in its native or in its phosphorylated form, pp35 could be released from the membranes in the presence of calcium-chelating agents (EDTA/EGTA); and EGF(Uro)-stimulated phosphorylation was reconstituted by adding back EDTA/EGTA eluates to EDTA/EGTA-washed membranes in the presence of calcium.	Egtazic Acid	229-233	dihydrouridine synthase 4 like	Homo sapiens	52-56
3079907-5	1986	Either in its native or in its phosphorylated form, pp35 could be released from the membranes in the presence of calcium-chelating agents (EDTA/EGTA); and EGF(Uro)-stimulated phosphorylation was reconstituted by adding back EDTA/EGTA eluates to EDTA/EGTA-washed membranes in the presence of calcium.	Egtazic Acid	229-233	epidermal growth factor	Homo sapiens	155-163
3079907-5	1986	Either in its native or in its phosphorylated form, pp35 could be released from the membranes in the presence of calcium-chelating agents (EDTA/EGTA); and EGF(Uro)-stimulated phosphorylation was reconstituted by adding back EDTA/EGTA eluates to EDTA/EGTA-washed membranes in the presence of calcium.	Egtazic Acid	229-233	dihydrouridine synthase 4 like	Homo sapiens	52-56
3079907-5	1986	Either in its native or in its phosphorylated form, pp35 could be released from the membranes in the presence of calcium-chelating agents (EDTA/EGTA); and EGF(Uro)-stimulated phosphorylation was reconstituted by adding back EDTA/EGTA eluates to EDTA/EGTA-washed membranes in the presence of calcium.	Egtazic Acid	229-233	epidermal growth factor	Homo sapiens	155-163
2999102-2	1985	However, the 1:2 complex dissociated into a 1:1 gelsolin:actin complex and monomeric actin when excess EGTA was added.	Egtazic Acid	103-107	gelsolin	Homo sapiens	48-56
2999102-3	1985	Plasma gelsolin bound tightly to the barbed ends of actin filaments and also severed filaments in the presence of Ca2+ and bound weakly to the filament barbed end in the presence of EGTA.	Egtazic Acid	182-186	gelsolin	Homo sapiens	7-15
2934249-4	1985	The study of the interaction with F-actin indicates that the binding of 1 molecule of aa or cc alpha-actinin/9-11 actin monomers is sufficient to produce maximal gelation in the presence of EGTA.	Egtazic Acid	190-194	actinin alpha 1	Homo sapiens	95-108
2932440-4	1985	Vanadate protected the A and B fragments from further hydrolysis and preserved the ability of the cleaved Ca2+-ATPase to form crystals and to show the characteristic conformational changes in response to Ca2+ and EGTA that are observed with the intact enzyme.	Egtazic Acid	213-217	dynein axonemal heavy chain 8	Homo sapiens	111-117
2415168-5	1985	The VIP-induced release of alpha-amylase was reduced by 40% when cells were incubated in a Ca2+-free medium in the presence of ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA).	Egtazic Acid	127-191	vasoactive intestinal peptide	Rattus norvegicus	4-7
2415168-5	1985	The VIP-induced release of alpha-amylase was reduced by 40% when cells were incubated in a Ca2+-free medium in the presence of ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA).	Egtazic Acid	193-197	vasoactive intestinal peptide	Rattus norvegicus	4-7
2416314-3	1985	The two activities were separated by serial elutions with 50 microM Ca2+ (HuIFN-alpha) followed by 2 mM EGTA (calmodulin).	Egtazic Acid	104-108	calmodulin 1	Homo sapiens	110-120
2932157-3	1985	The effect of increased pH on the differences in the rate of ATP hydrolysis by actomyosin containing phosphorylated myosin as compared with that of the dephosphorylated one, observed in the presence of EGTA, is abolished by addition of Ca2+.	Egtazic Acid	202-206	myosin heavy chain 14	Homo sapiens	83-89
3932607-5	1985	Maximum light-evoked tension is reduced by exposure to Ca2+-free solutions containing EGTA and high K+ and is restored by incubation in solutions containing Ca2+.	Egtazic Acid	86-90	carbonic anhydrase 2	Homo sapiens	55-58
4060972-9	1985	Decreased rIGF-II release in the presence of EGTA and EDTA is not due to irreversible cell damage since the secretion of this SM was restored to normal during subsequent reincubation in MEM alone.	Egtazic Acid	45-49	insulin-like growth factor 2	Rattus norvegicus	10-17
3840495-6	1985	PTH + 1.00 micron/min EGTA lowered Ca++ more, and 1,25(OH)2D3 increased to 148 +/- 29 (P less than 0.01 vs. saline or PTH alone).	Egtazic Acid	22-26	parathyroid hormone	Rattus norvegicus	0-7
2995403-4	1985	Chromatography of actin and gelsolin mixtures in EGTA-containing solutions isolates a stable binary complex, GA1Ca1 (Kurth, M., and J. Bryan, 1984, J. Biol.	Egtazic Acid	49-53	gelsolin	Oryctolagus cuniculus	28-36
3840495-7	1985	PTH + 1.33 micron/min EGTA lowered Ca++ below values seen with saline or PTH alone, and 1,25(OH)2D3 rose to 267 +/- 46 (P less than 0.003 vs. all other groups).	Egtazic Acid	22-26	parathyroid hormone	Rattus norvegicus	0-7
2995403-18	1985	Occupancy of the EGTA-stable binding site yields a gelsolin-actin complex that can no longer sever filaments, but can cap filament ends.	Egtazic Acid	17-21	gelsolin	Oryctolagus cuniculus	51-59
3840495-8	1985	Thus, during PTH infusion lowering Ca++ with EGTA raised 1,25(OH)2D3 progressively.	Egtazic Acid	45-49	parathyroid hormone	Rattus norvegicus	13-16
2994486-3	1985	A model of contracted, irreversibly aggregated thrombin-activated human platelets relaxes when treated with ethyleneglycol-bis(beta-aminoethylether-N,N"-tetraacetic acid (EGTA) in the presence of Mg2+.	Egtazic Acid	108-169	coagulation factor II, thrombin	Homo sapiens	47-55
4030790-10	1985	N-Ethylmaleimide, ethylenediaminetetraacetic acid, AMP, pyrophosphate, spermine, spermidine, and high concentrations of potassium inhibited both P1 and eIF-2 alpha phosphorylation by the purified kinase, whereas ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid and phenanthroline did not significantly affect the phosphorylation of either protein P1 or eIF-2 alpha.	Egtazic Acid	212-281	eukaryotic translation initiation factor 2A	Mus musculus	152-163
4041827-9	1985	The excitatory effects of NT1-13 and NT8-13 were maintained in medium which effectively blocked synaptic transmission (0 mM Ca2+/12 mM Mg2+ 1 mM EGTA).	Egtazic Acid	145-149	3'-nucleotidase	Homo sapiens	26-32
2994486-3	1985	A model of contracted, irreversibly aggregated thrombin-activated human platelets relaxes when treated with ethyleneglycol-bis(beta-aminoethylether-N,N"-tetraacetic acid (EGTA) in the presence of Mg2+.	Egtazic Acid	171-175	coagulation factor II, thrombin	Homo sapiens	47-55
2992708-10	1985	Calcium redistributed soluble striatal calmodulin into the particulate fraction and EGTA shifted calmodulin from the particulate into the soluble fraction.	Egtazic Acid	84-88	calmodulin 2	Mus musculus	97-107
2994814-2	1985	This response was found in the apical and basal dendrites and, like the hyperpolarizing response of the dendrites to GABA, appeared to be Ca2+-dependent since it was blocked or reduced by intracellular injection of EGTA or extracellular application of cadmium.	Egtazic Acid	215-219	carbonic anhydrase 2	Rattus norvegicus	138-141
2412702-9	1985	The initial Ca2+ mobilizing effect of angiotensin II was also observed in a Ca2+-free media which contained EGTA, indicating that this effect is not triggered by increased Ca2+ influx.	Egtazic Acid	108-112	angiotensinogen	Rattus norvegicus	38-52
3927744-7	1985	Addition of 0.1 mM EGTA to Ca2+-free medium not only inhibited GnRH-induced release and glycosylation of LH but also uptake of precursors and glycosylation and translation of total protein.	Egtazic Acid	19-23	gonadotropin releasing hormone 1	Rattus norvegicus	63-67
2861080-4	1985	The stimulation of SRIF release induced by depolarizing agents was abolished or diminished by 1) omission of extracellular calcium, 2) chelation of extracellular calcium by EGTA, and 3) the calcium channel blocker verapamil, indicating calcium dependence of this process.	Egtazic Acid	173-177	somatostatin	Mus musculus	19-23
3935303-10	1985	Myelin basic protein, but not calcineurin, inhibited the EGTA-sensitive adenylate cyclase activity.	Egtazic Acid	57-61	myelin basic protein	Rattus norvegicus	0-20
2994715-5	1985	In this paper, the interactions with actin of the ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) stable 1:1 gelsolin-actin complexes are compared with those of free gelsolin.	Egtazic Acid	50-119	gelsolin	Homo sapiens	138-146
2994715-5	1985	In this paper, the interactions with actin of the ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) stable 1:1 gelsolin-actin complexes are compared with those of free gelsolin.	Egtazic Acid	121-125	gelsolin	Homo sapiens	138-146
2994715-5	1985	In this paper, the interactions with actin of the ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) stable 1:1 gelsolin-actin complexes are compared with those of free gelsolin.	Egtazic Acid	121-125	gelsolin	Homo sapiens	195-203
2994715-6	1985	The abilities of free or complexed gelsolin to sever actin filaments, nucleate filament assembly, bind to the fast growing (+) filament ends, and lower the filament size distribution in the presence of either Ca2+ or EGTA were examined.	Egtazic Acid	217-221	gelsolin	Homo sapiens	35-43
2994715-8	1985	The gelsolin-actin complexes, however, differ from free gelsolin in that they have a higher affinity for (+) filament ends in EGTA and they cannot sever filaments in calcium.	Egtazic Acid	126-130	gelsolin	Homo sapiens	4-12
2994715-8	1985	The gelsolin-actin complexes, however, differ from free gelsolin in that they have a higher affinity for (+) filament ends in EGTA and they cannot sever filaments in calcium.	Egtazic Acid	126-130	gelsolin	Homo sapiens	56-64
2861080-8	1985	The stimulation of SRIF release induced by A23187 was not inhibited by omission of extracellular calcium or by verapamil, but was inhibited by EGTA and trifluperazine.	Egtazic Acid	143-147	somatostatin	Mus musculus	19-23
3924120-5	1985	When microsomes were isolated in the presence of 5 mM EGTA, to remove endogenous calmodulin, the same enhancing effect of Ca2+ on the acetylation reaction was observed.	Egtazic Acid	54-58	calmodulin 1	Rattus norvegicus	81-91
2860207-4	1985	This effect disappeared when drugs (EGTA, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, Gallopamil) preventing Ca2+- and calmodulin-dependent processes were included in the incubating medium.	Egtazic Acid	36-40	carbonic anhydrase 2	Rattus norvegicus	117-137
3927934-0	1985	EGTA-extractable calmodulin in platelet membrane is lower in alcoholics than in controls.	Egtazic Acid	0-4	calmodulin 1	Homo sapiens	17-27
3925951-2	1985	When the cells were exposed to high extracellular K+ in Ca+-free media containing 2mM EGTA, there was a transient and dose-dependent elevation of cytosolic Ca2+ concentrations.	Egtazic Acid	86-90	carbonic anhydrase 2	Rattus norvegicus	156-159
3897255-2	1985	Calmodulin and its guanidinated, iodinated, and performic acid-oxidized derivatives can be isolated on alkylphenyl columns by using gradients of acetonitrile in 10 mM potassium phosphate, pH 6.0, 2 mM EGTA.	Egtazic Acid	201-205	calmodulin 1	Homo sapiens	0-10
3996585-2	1985	The 90-kDa protein existed in the form of a complex with actin on a DNase I column even in the presence of 5 mM EGTA, indicating that the 90-kDa protein binds tightly to actin in a Ca2+-insensitive manner.	Egtazic Acid	112-116	deoxyribonuclease 1	Bos taurus	68-75
2987120-4	1985	The IP3 formation was not stimulated by the calcium ionophore A23187 (5 microM), nor were angiotensin II-induced changes in IP3 formation inhibited by the removal of extracellular calcium with EGTA.	Egtazic Acid	193-197	angiotensinogen	Rattus norvegicus	90-104
3157691-4	1985	To determine the temporal relationship between cell fusion and the accumulation of ankyrin and alpha- and beta-spectrin, we treated presumptive myoblasts with 2 mM EGTA, which resulted in the complete inhibition of cell fusion.	Egtazic Acid	164-168	spectrin alpha, non-erythrocytic 1	Gallus gallus	95-119
3157691-7	1985	Upon release from the EGTA block, the cells fused rapidly (less than 11 h), and the accumulation of ankyrin and alpha- and beta-spectrin was reinitiated after a lag period of 3-5 h at a rate similar to that in control cells.	Egtazic Acid	22-26	spectrin alpha, non-erythrocytic 1	Gallus gallus	112-136
3157691-8	1985	The inhibition in the accumulation of newly synthesized ankyrin, alpha-spectrin, and beta-spectrin in EGTA-treated myoblasts was not characteristic of all structural proteins, since the accumulation of the muscle-specific intermediate filament protein desmin was the same in control and fusion-blocked cells.	Egtazic Acid	102-106	spectrin alpha, non-erythrocytic 1	Gallus gallus	65-79
3159962-5	1985	The SME fraction exhibited Ca2+-ATPase activity, using 200 nM free Ca2+, of 90 and 21 mU mg-1 protein, respectively, using CDTA and EGTA as buffering ligands.	Egtazic Acid	132-136	dynein axonemal heavy chain 8	Homo sapiens	32-38
2987237-5	1985	An ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid-sensitive, calmodulin-independent, p-nitrophenyl phosphatase does not bind to the affinity column and is resolved from calcineurin at this step.	Egtazic Acid	3-72	calmodulin 1	Homo sapiens	84-94
4027284-2	1985	It was shown that in membranes A placed into an incubation medium containing 0.1 mM EGTA (pH 7.4) the overall effect of exogenous calmodulin is due to the increase in the maximal activity of the enzyme, its affinity for Ca2+ being unaffected thereby.	Egtazic Acid	84-88	calmodulin 1	Homo sapiens	130-140
3922884-6	1985	When EGTA was added to chelate external calcium, the angiotensin II-induced increases in peak [Ca2+]i were attenuated and the plateau phase was abolished.	Egtazic Acid	5-9	angiotensinogen	Rattus norvegicus	53-67
2985726-2	1985	High K+ concentrations, hypothalamic extract, synthetic thyrotrophin-releasing hormone (TRH) and dibutyryl cyclic AMP (dbcAMP) all stimulated release of prolactin from control (non EGTA-treated) hemianterior pituitary glands.	Egtazic Acid	181-185	thyrotropin releasing hormone	Homo sapiens	88-91
2985726-2	1985	High K+ concentrations, hypothalamic extract, synthetic thyrotrophin-releasing hormone (TRH) and dibutyryl cyclic AMP (dbcAMP) all stimulated release of prolactin from control (non EGTA-treated) hemianterior pituitary glands.	Egtazic Acid	181-185	prolactin	Homo sapiens	153-162
2985726-4	1985	Reduction of Ca2+ availability with EGTA or verapamil reduced basal release of prolactin, prevented the prolactin-stimulating effects of high K+ concentrations and TRH, and markedly attenuated responses to hypothalamic extract and dbcAMP, EGTA being more effective than verapamil.	Egtazic Acid	36-40	prolactin	Homo sapiens	79-88
2985726-4	1985	Reduction of Ca2+ availability with EGTA or verapamil reduced basal release of prolactin, prevented the prolactin-stimulating effects of high K+ concentrations and TRH, and markedly attenuated responses to hypothalamic extract and dbcAMP, EGTA being more effective than verapamil.	Egtazic Acid	36-40	prolactin	Homo sapiens	104-113
2985726-4	1985	Reduction of Ca2+ availability with EGTA or verapamil reduced basal release of prolactin, prevented the prolactin-stimulating effects of high K+ concentrations and TRH, and markedly attenuated responses to hypothalamic extract and dbcAMP, EGTA being more effective than verapamil.	Egtazic Acid	36-40	thyrotropin releasing hormone	Homo sapiens	164-167
4011406-2	1985	Five minutes perfusion with Ca-free solution containing 1 mM EGTA, followed by 10 min of reperfusion in 1.8 mM Ca causes irreversible contracture, K loss, increase in Na and Ca and a massive release of myoglobin and other cellular material into the perfusate (the calcium paradox).	Egtazic Acid	61-65	myoglobin	Rattus norvegicus	202-211
3927934-7	1985	EGTA-extractable calmodulin in pre-disulfiram, post-disulfiram, and control subjects was 5.07 +/- 2.2 (SD), 5.19 +/- 1.7 (SD), and 10.5 +/- 6.7 (SD) ng calmodulin/mg whole platelet protein.	Egtazic Acid	0-4	calmodulin 1	Homo sapiens	17-27
3927934-7	1985	EGTA-extractable calmodulin in pre-disulfiram, post-disulfiram, and control subjects was 5.07 +/- 2.2 (SD), 5.19 +/- 1.7 (SD), and 10.5 +/- 6.7 (SD) ng calmodulin/mg whole platelet protein.	Egtazic Acid	0-4	calmodulin 1	Homo sapiens	152-162
3927934-8	1985	The EGTA-extractable calmodulin was significantly lower in alcoholics pre- or post-disulfiram than in controls (p less than 0.025).	Egtazic Acid	4-8	calmodulin 1	Homo sapiens	21-31
3856849-4	1985	Addition of EGTA to the reaction mixture also stimulated the rate of actin polymerization; however, the effect of calmodulin on actin polymerization is not due to Ca2+ chelation, as is presumed to be the case for EGTA.	Egtazic Acid	213-217	calmodulin 1	Homo sapiens	114-124
2983988-5	1985	This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+.	Egtazic Acid	89-93	calmodulin 2	Mus musculus	25-35
2983988-5	1985	This appeared to involve calmodulin because after extraction of calmodulin with EDTA and EGTA from sensitive membranes, they could not be made insensitive by the addition of tropomyosin and Ca2+.	Egtazic Acid	89-93	calmodulin 2	Mus musculus	64-74
3919035-3	1985	Brief treatment of cells at 24 hr of culture with the Ca2+ ionophore A23187 in combination with EGTA resulted in a larger release of Ca2+ from cells in mitogen-stimulated cultures than from cells in control cultures.	Egtazic Acid	96-100	carbonic anhydrase 2	Homo sapiens	133-136
3158825-6	1985	In platelet-rich plasma the potency and efficacy of AVP in causing a shape change were similar in the presence and absence of EGTA, whereas with EDTA in the medium AVP had no effect.	Egtazic Acid	126-130	arginine vasopressin	Homo sapiens	52-55
3918585-7	1985	In the presence of phenylephrine and if extracellular Mg2+ concentrations were lowered by omitting Mg2+ from the medium or by preperfusion with EGTA, exogenous Ca2+ was glycogenolytically effective and also produced a transient K+ uptake.	Egtazic Acid	144-148	carbonic anhydrase 2	Rattus norvegicus	160-163
3155739-12	1985	Treatment of vesicles with EGTA dissociated the GP IIb-IIIa complex.	Egtazic Acid	27-31	integrin subunit alpha 2b	Homo sapiens	48-54
2983716-2	1985	The concentration of calmodulin in this fraction is relatively high, about 1.6 micrograms/mg protein, and can not be decreased with EGTA.	Egtazic Acid	132-136	calmodulin 1	Rattus norvegicus	21-31
3918996-5	1985	The Ca2+ ionophore A23187 and the enzyme thrombin produced dose-related luminescent signals in both Ca2+-containing and EGTA-containing media.	Egtazic Acid	120-124	coagulation factor II, thrombin	Homo sapiens	41-49
3917939-3	1985	When liver mitochondria were prepared from rats treated with adrenaline, and then incubated in Na-free media containing EGTA, both PDH and OGDH activities were found to be enhanced.	Egtazic Acid	120-124	oxoglutarate dehydrogenase	Rattus norvegicus	139-143
3155695-4	1985	Synexin binding to either plasma membrane or granule membrane coated beads was saturable, was partially reversible by EGTA and was directly observed by SDS-polyacrylamide gel electrophoresis.	Egtazic Acid	118-122	annexin A7	Homo sapiens	0-7
2578390-5	1985	ADF is heat and trypsin-sensitive, inactivated by EGTA, not stained by HIO4/Schiff on sodium dodecyl sulfate/polyacrylamide gel electrophoresis (SDS/PAGE), and not retained on a concanavalin-A-Sepharose column.	Egtazic Acid	50-54	destrin, actin depolymerizing factor	Homo sapiens	0-3
6398218-1	1984	Calmodulin levels in normal human thyroids and Graves" disease thyroids were measured by specific radioimmunoassay in the presence of ethyleneglycol-bis-(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	134-203	calmodulin 1	Homo sapiens	0-10
3917614-7	1985	Injection of the Ca2+-chelator EGTA into the cell suppressed both TRH and Ca2+ ionophore-induced hyperpolarizations.	Egtazic Acid	31-35	thyrotropin releasing hormone	Rattus norvegicus	66-69
3883125-9	1985	The occurrence of these effects was prevented by EGTA or dibucaine, a potent inhibitor of phospholipase A2.	Egtazic Acid	49-53	phospholipase A2 group IB	Rattus norvegicus	90-106
6442108-3	1984	The reaction was found to be first order in EGTA and complex order in calcium, with an observed second-order rate constant (pH 7, T = 25 degrees C, ionic strength = 0.1 M) of about 1.5 X 10(6) M-1 s-1.	Egtazic Acid	44-48	tumor associated calcium signal transducer 2	Homo sapiens	193-200
6335396-6	1984	This process, normally counteracted by C1INH, worked more efficiently in EGTA-NHS than in NHS, indicating that the C1s-mediated reactions, initiated by presently unknown mechanisms, were less extensively regulated outside of the Ca2+-dependent C1 complex.	Egtazic Acid	73-77	plasma protease C1 inhibitor	Oryctolagus cuniculus	39-44
6497381-3	1984	The calmodulin-sensitive enzyme, approximately 10% of the recovered activity, bound to the affinity column and was eluted with buffer containing 2 mM EGTA.	Egtazic Acid	150-154	calmodulin 1	Rattus norvegicus	4-14
6477972-5	1984	By taking the effects of EGTA into consideration, the phosphorylation of Mr 64 000 and 21 000 proteins, of which the latter was identified as the light chain of myosin, seemed to be involved in the signal-transmission mechanism of the induction of the NADPH oxidase responsible for the "respiratory burst".	Egtazic Acid	25-29	myosin X	Sus scrofa	161-167
6436256-3	1984	Thyrotropin-releasing hormone (TRH) rapidly enhanced amino acid incorporation and prolactin production, with both effects being reserved by EGTA in excess of extracellular Ca2+ or prevented by cellular Ca2+ depletion.	Egtazic Acid	140-144	thyrotropin releasing hormone	Rattus norvegicus	0-29
6088691-5	1984	In this case, there was also more calmodulin bound to chromaffin granules when EGTA was omitted from the density gradient.	Egtazic Acid	79-83	calmodulin	Bos taurus	34-44
6437647-2	1984	Inhibition occurs in the presence of Hg2+ concentrations lower than the molarity of the tubulin, even in the presence of 0.5 mM ethylenebis(oxyethylenenitrilo)tetraacetic acid.	Egtazic Acid	128-175	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	37-40
6432060-2	1984	The increase of ornithine decarboxylase activity in serum-stimulated C6-2B cells was prevented by the calcium chelator EGTA, but EGTA had no effect upon RNA synthesis as judged by [3H]uridine incorporation into RNA.	Egtazic Acid	119-123	ornithine decarboxylase, structural 1	Mus musculus	16-39
6432060-4	1984	EGTA appeared to inhibit the synthesis of ornithine decarboxylase, because the half-life values of ornithine decarboxylase activity were similar (37-47 min) in the presence of EGTA or protein synthesis inhibitors such as cycloheximide or emetine.	Egtazic Acid	0-4	ornithine decarboxylase 1	Rattus norvegicus	42-65
6432060-4	1984	EGTA appeared to inhibit the synthesis of ornithine decarboxylase, because the half-life values of ornithine decarboxylase activity were similar (37-47 min) in the presence of EGTA or protein synthesis inhibitors such as cycloheximide or emetine.	Egtazic Acid	0-4	ornithine decarboxylase 1	Rattus norvegicus	99-122
6432060-4	1984	EGTA appeared to inhibit the synthesis of ornithine decarboxylase, because the half-life values of ornithine decarboxylase activity were similar (37-47 min) in the presence of EGTA or protein synthesis inhibitors such as cycloheximide or emetine.	Egtazic Acid	176-180	ornithine decarboxylase 1	Rattus norvegicus	42-65
6432060-5	1984	Also, calcium readdition rapidly reversed EGTA inhibition of ornithine decarboxylase activity by a mechanism which could be blocked by cycloheximide.	Egtazic Acid	42-46	ornithine decarboxylase 1	Rattus norvegicus	61-84
6432061-3	1984	The calcium chelator EGTA (pCa 6.4) inhibited basal and polyamine-stimulated antizyme activity, and this inhibition was prevented by concurrent incubation with calcium, but not with magnesium.	Egtazic Acid	21-25	ornithine decarboxylase antizyme 1	Mus musculus	77-85
6432061-4	1984	EGTA appeared to block antizyme synthesis, because the half-life values of antizyme activity in the presence of EGTA or cycloheximide were similar (121-143 min).	Egtazic Acid	0-4	ornithine decarboxylase antizyme 1	Mus musculus	23-31
6432061-4	1984	EGTA appeared to block antizyme synthesis, because the half-life values of antizyme activity in the presence of EGTA or cycloheximide were similar (121-143 min).	Egtazic Acid	0-4	ornithine decarboxylase antizyme 1	Mus musculus	75-83
6432061-4	1984	EGTA appeared to block antizyme synthesis, because the half-life values of antizyme activity in the presence of EGTA or cycloheximide were similar (121-143 min).	Egtazic Acid	112-116	ornithine decarboxylase antizyme 1	Mus musculus	75-83
6432061-5	1984	Also, calcium readdition rapidly reversed EGTA inhibition of antizyme activity by a mechanism which could be blocked by cycloheximide.	Egtazic Acid	42-46	ornithine decarboxylase antizyme 1	Mus musculus	61-69
6432061-6	1984	The ability of EGTA to inhibit spermidine-stimulated antizyme activity was not due to reduced spermidine uptake, because EGTA actually stimulated [3H]spermidine accumulation in the trichloroacetic acid-soluble fraction of C6-2B cells after 3 h.	Egtazic Acid	15-19	ornithine decarboxylase antizyme 1	Mus musculus	53-61
6437957-4	1984	The mitochondrial calcium depletion by 10 mM EGTA treatment produced a remarkable reduction in alanine aminotransferase activity increased by CT, although EGTA treatment did not alter basal enzyme activity.	Egtazic Acid	45-49	calcitonin-related polypeptide alpha	Rattus norvegicus	142-144
6206303-8	1984	The endogenous calmodulin present on the isolated lamellar bodies is not removed by treatment of the lamellar bodies with ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid.	Egtazic Acid	122-186	calmodulin 1	Rattus norvegicus	15-25
6327694-2	1984	Both newly formed and long-term culture-generated substratum adhesion sites, generated by EGTA-mediated detachment of Balb/c SVT2 cells, were extracted with an eta-octyl-beta-D-glucopyranoside buffer containing salt and several protease inhibitors under conditions which result in maximal solubilization of the sulfate-radiolabeled proteoglycans.	Egtazic Acid	90-94	endothelin receptor type A	Homo sapiens	105-108
6436084-2	1984	In the presence of either divalent cationic chelator (EGTA) or calcium channel blocker (verapamil, nifedipine), carbachol-stimulated gastrin release was inhibited completely to values that were not significantly different from non-stimulated control.	Egtazic Acid	54-58	gastrin	Rattus norvegicus	133-140
6436084-4	1984	Inhibition by EGTA and verapamil of carbachol-stimulated gastrin release during the initial 30 min of culture suggests, but does not prove, that these agents may also effect intracellular availability and movement of calcium.	Egtazic Acid	14-18	gastrin	Rattus norvegicus	57-64
6430234-5	1984	Stimulation of PMN in the presence of 0.01 M EDTA or EGTA decreased PAF synthesis and release by greater than 95%.	Egtazic Acid	53-57	PCNA clamp associated factor	Homo sapiens	68-71
6330172-10	1984	EGTA (10(-3) M) and LaCl3 (10(-3) M) inhibited the action of gastrin by 67 and 52%, respectively.	Egtazic Acid	0-4	gastrin	Cavia porcellus	61-68
6330059-7	1984	We have shown previously that the Mr = 130,000 species is an EGTA-stable binary complex of one actin and one gelsolin.	Egtazic Acid	61-65	actin	Oryctolagus cuniculus	95-100
6330059-7	1984	We have shown previously that the Mr = 130,000 species is an EGTA-stable binary complex of one actin and one gelsolin.	Egtazic Acid	61-65	gelsolin	Homo sapiens	109-117
6330059-10	1984	Sedimentation and gel filtration experiments using purified platelet gelsolin and rabbit skeletal muscle actin demonstrated that formation of the EGTA-stable binary complex required Ca2+.	Egtazic Acid	146-150	gelsolin	Oryctolagus cuniculus	69-77
6330059-10	1984	Sedimentation and gel filtration experiments using purified platelet gelsolin and rabbit skeletal muscle actin demonstrated that formation of the EGTA-stable binary complex required Ca2+.	Egtazic Acid	146-150	actin	Oryctolagus cuniculus	105-110
6330059-11	1984	At least one additional actin is bound to the binary complex in the presence of Ca2+, but is not sufficiently stable to be purified when EGTA is added.	Egtazic Acid	137-141	actin	Oryctolagus cuniculus	24-29
6330060-5	1984	Binding of monomeric NBD-actin to the binary complex results in a 2.5-fold increase in the emission at 530 nm in the presence of Ca2+ and a 2-fold increase in the presence of EGTA.	Egtazic Acid	175-179	actin	Oryctolagus cuniculus	25-30
6233277-5	1984	However, calmodulin-dependent reconstitution of Ca2+ uptake in EGTA-extracted sarcoplasmic reticulum vesicles was inhibited by 48/80.	Egtazic Acid	63-67	calmodulin 1	Homo sapiens	9-19
6433612-8	1984	Prl secretion by 235-1 cells is not affected by dopaminergic agonists and antagonists, TRH, or oestradiol-17 beta but is inhibited in the presence of EGTA or monensin, an ionophore that is believed to act at the level of the Golgi complex.	Egtazic Acid	150-154	prolactin	Rattus norvegicus	0-3
6204208-7	1984	In the presence of EGTA, gelsolin has no effect on the movement of membranous organelles, but in the presence of 10 microM Ca2+ it completely blocks transport of all membranous organelles.	Egtazic Acid	19-23	gelsolin	Homo sapiens	25-33
6734820-5	1984	The calmodulin bound could be eluted with EGTA.	Egtazic Acid	42-46	calmodulin 1	Homo sapiens	4-14
6733116-3	1984	Calmodulin and S-100 protein were eluted from the aminoocytl -agarose column with 1 mM EGTA in the presence of 0.15 M NaCl and the elution of troponin-C was Ca2+-independently carried out with 0.3 M NaCl.	Egtazic Acid	87-91	calmodulin 1	Homo sapiens	0-10
6425298-4	1984	The TRH-induced spike phase was attenuated but not abolished by prior addition of EGTA, while the plateau phase was eliminated by EGTA.	Egtazic Acid	82-86	thyrotropin releasing hormone	Rattus norvegicus	4-7
6733116-3	1984	Calmodulin and S-100 protein were eluted from the aminoocytl -agarose column with 1 mM EGTA in the presence of 0.15 M NaCl and the elution of troponin-C was Ca2+-independently carried out with 0.3 M NaCl.	Egtazic Acid	87-91	S100 calcium binding protein B	Homo sapiens	15-20
6425298-4	1984	The TRH-induced spike phase was attenuated but not abolished by prior addition of EGTA, while the plateau phase was eliminated by EGTA.	Egtazic Acid	130-134	thyrotropin releasing hormone	Rattus norvegicus	4-7
6423774-4	1984	The binding of CPZ to 3 microM S-100 is half-saturated by 0.18 microM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 microM CPZ in the presence of Mg2+ plus EGTA.	Egtazic Acid	160-164	S100 calcium binding protein A1	Homo sapiens	31-36
6424741-5	1984	Pretreatment of FVIII-vWF with the calcium chelator EGTA (10 mM) resulted in loss of the ability to facilitate platelet adherence, while the ristocetin cofactor activity remained intact.	Egtazic Acid	52-56	coagulation factor VIII	Homo sapiens	16-21
6424741-5	1984	Pretreatment of FVIII-vWF with the calcium chelator EGTA (10 mM) resulted in loss of the ability to facilitate platelet adherence, while the ristocetin cofactor activity remained intact.	Egtazic Acid	52-56	von Willebrand factor	Homo sapiens	22-25
6431312-0	1984	The synaptically evoked late hyperpolarisation in hippocampal CA1 pyramidal cells is resistant to intracellular EGTA.	Egtazic Acid	112-116	carbonic anhydrase 1	Homo sapiens	62-65
6231052-6	1984	Following extensive washings of these membranes with EGTA/EDTA solutions, the Ca2+ uptake activity demonstrated an affinity for calmodulin of 30 nM and an affinity for Ca2+ of 2 microM.	Egtazic Acid	53-57	calmodulin	Oryctolagus cuniculus	128-138
6325021-3	1984	In the presence of Ca2+, lymphocyte Cam stimulated activator-depleted dog brain phosphodiesterase; this effect was inhibited by trifluoperazine (TFP) or by EGTA.	Egtazic Acid	156-160	calmodulin 1	Homo sapiens	36-39
6325021-4	1984	By the RIA technique, the EGTA-soluble Cam content of resting lymphocytes constituted 0.58% of the total protein; the total Cam was comparable to the content of other major proteins in lymphocytes, such as actin, tubulin, and intermediate filament protein.	Egtazic Acid	26-30	calmodulin 1	Homo sapiens	39-42
6231922-7	1984	The several observations made indicate that the Ca2+-insensitive component of fusion is associated with degradation of ankyrin (band 2.1 protein) to band 2.3-2.6 proteins and to smaller polypeptides by a serine proteinase that is inhibited by Tos-Lys-CH2Cl, and that the component of fusion inhibited by EGTA and N-ethylmaleimide is associated with degradation of band 3 protein to band 4.5 protein by a Ca2+-activated cysteine proteinase.	Egtazic Acid	304-308	endogenous retrovirus group K member 10	Homo sapiens	211-221
6323689-6	1984	In vitro, pretreatment of striatal particulates with the Ca++-chelating agent ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (1.2 mM) to remove endogenous Ca++ and calmodulin or the addition of Ca++ and calmodulin to the striatal particulates did not affect the binding affinities of dopamine agonists and antagonists to the receptors.	Egtazic Acid	78-142	calmodulin 1	Rattus norvegicus	221-231
6321479-9	1984	The inhibition of calmodulin by ophiobolin A could not be reversed by dialysis, dilution, nor denaturation by urea in the presence of methanol followed by renaturation, and was much more pronounced in solutions containing Ca2+ than in those containing EGTA.	Egtazic Acid	252-256	calmodulin1	Zea mays	18-28
6323472-1	1984	Limited proteolysis of calmodulin with trypsin in the presence of ethylene glycol bis(beta-aminoethyl ether)-N, N,N",N"-tetracetic acid (EGTA) or Ca2+ was performed according to a modification of the method of Drabikowski et al.	Egtazic Acid	137-141	calmodulin 1	Homo sapiens	23-33
6321088-2	1984	In erythrocyte membranes subjected to calmodulin depletion by treatment with EGTA, both the affinity of the calcium pump for Ca2+ and its maximal activity were the same in normotensive and hypertensive patients.	Egtazic Acid	77-81	calmodulin 1	Homo sapiens	38-48
6321088-4	1984	The addition of calmodulin to erythrocyte membranes obtained without EGTA treatment resulted in a smaller increase of the maximal activity of the calcium pump only.	Egtazic Acid	69-73	calmodulin 1	Homo sapiens	16-26
6324862-1	1984	Cyclic nucleotide phosphodiesterase (0.07 nM) was activated by near stoichiometric concentrations of [3-(2-pyridyldithio)propionyl]calmodulin (PDP-CaM) after initial incubation of these proteins at 200-fold higher concentrations; activity in assays with EGTA was 80% of that in the presence of Ca2+.	Egtazic Acid	254-258	phosphodiesterase 3B	Homo sapiens	0-35
6230247-6	1984	Cell-CAM 105 and CDP-1 are present on the cell surface as separate components, as judged by the fact that both EGTA treatment and trypsin treatment of hepatocytes selectively make the cells insensitive to blocking of aggregation by antibodies against CDP-1 but not by antibodies against cell-CAM 105.	Egtazic Acid	111-115	CEA cell adhesion molecule 1	Rattus norvegicus	0-12
6230247-6	1984	Cell-CAM 105 and CDP-1 are present on the cell surface as separate components, as judged by the fact that both EGTA treatment and trypsin treatment of hepatocytes selectively make the cells insensitive to blocking of aggregation by antibodies against CDP-1 but not by antibodies against cell-CAM 105.	Egtazic Acid	111-115	cut-like homeobox 1	Rattus norvegicus	17-22
6441573-4	1984	A linear dependence of measured electrode potentials with Nernstian behaviour on the calculated pCa2+free in the Ca/EGTA solutions has been obtained with carefully equalized stock solutions.	Egtazic Acid	116-120	prostate cancer associated transcript 2	Homo sapiens	96-100
6201593-2	1984	The presence of Ca2+ in the electron-dense particles was indicated by their extraction with EGTA and by the use of energy-dispersive X-ray microanalysis.	Egtazic Acid	92-96	carbonic anhydrase 2	Homo sapiens	16-19
6712599-6	1984	Translated calmodulin was identified by its heat-stability, its co-migration with authentic anterior-pituitary calmodulin on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis, its acidic isoelectric point (4.15) on flat-bed isoelectric focusing, its Ca2+-dependent binding to fluphenazine-Sepharose 6B, and its co-elution from this gel with authentic unlabelled calmodulin with EGTA buffer.	Egtazic Acid	387-391	calmodulin-3	Sus scrofa	11-21
6319953-4	1984	With 1.0 mmol/L EGTA and no added calcium (free calcium less than 10(-8) mol/L), half-maximal inhibition of PTH release accumulation occurred at 10 to 15 mmol/L magnesium.	Egtazic Acid	16-20	parathyroid hormone	Bos taurus	108-111
6420403-2	1984	1) Calmodulin affinity chromatography: both MAP2 and tau proteins were bound to calmodulin affinity columns in the presence of calcium and released with ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA), whereas tubulin was not bound.	Egtazic Acid	153-222	calmodulin 1	Homo sapiens	3-13
6420403-2	1984	1) Calmodulin affinity chromatography: both MAP2 and tau proteins were bound to calmodulin affinity columns in the presence of calcium and released with ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA), whereas tubulin was not bound.	Egtazic Acid	153-222	microtubule associated protein 2	Homo sapiens	44-48
6420403-2	1984	1) Calmodulin affinity chromatography: both MAP2 and tau proteins were bound to calmodulin affinity columns in the presence of calcium and released with ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA), whereas tubulin was not bound.	Egtazic Acid	224-228	microtubule associated protein 2	Homo sapiens	44-48
6420403-5	1984	3</protein-id>) Equilibrium binding of 125I-calmodulin to MAP2 and tau using the Hummel-Dreyer technique on Sephadex G-100 columns: MAP2 and tau proteins bound 125I-calmodulin in a calcium-dependent manner and no binding occurred in the presence of EGTA.	Egtazic Acid	249-253	microtubule associated protein 2	Homo sapiens	132-136
6088131-3	1984	In Ca-free or Ca-depleted (+EGTA) buffers secretion of both active and inactive renin was increased.	Egtazic Acid	28-32	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	80-85
6418524-6	1984	Addition of 0.5 mM EGTA to the reaction mixture resulted in an approximate 30% increase in basal adenylate cyclase activity and a similar percentage increase in the activity measured in the presence of guanosine triphosphate or NaF, known activators of parathyroid adenylate cyclase.	Egtazic Acid	19-23	C-X-C motif chemokine ligand 8	Homo sapiens	228-231
6204810-2	1984	In the muscle depolarized by 540 mM KCl + 5 mM EGTA solution, 8-bromo-cyclic GMP could not relax Ca-contracture.	Egtazic Acid	47-51	5'-nucleotidase, cytosolic II	Homo sapiens	77-80
6201430-10	1984	Ruthenium red and EGTA protected mitochondria from the destructive Ca2+ release and induced an immediate, slow release of Ca2+ and phosphate.	Egtazic Acid	18-22	carbonic anhydrase 2	Rattus norvegicus	67-70
6201430-10	1984	Ruthenium red and EGTA protected mitochondria from the destructive Ca2+ release and induced an immediate, slow release of Ca2+ and phosphate.	Egtazic Acid	18-22	carbonic anhydrase 2	Rattus norvegicus	122-125
6317713-8	1984	Calmodulin at 0.5-10 micrograms/ml stimulated the Ca pumping activity of EGTA-washed podosomes.	Egtazic Acid	73-77	calmodulin-3	Cavia porcellus	0-10
6422452-2	1984	Intravenous injections of EGTA significantly depressed blood ionic calcium concentrations (hypocalcemia), and the recovery from this hypocalcemia was dependent upon the presence of parathyroid hormone (PTH).	Egtazic Acid	26-30	parathyroid hormone	Gallus gallus	181-200
6690450-6	1984	Subsequent depletion of Ca2+ either by addition of ethylene glycol bis (beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA) or by replacement of medium with Ca2+-free medium, resulted in obliteration of ODC activity 4 hours later.	Egtazic Acid	51-116	ornithine decarboxylase 1	Homo sapiens	203-206
6324962-6	1984	Further, the spontaneous feeding induced by CaM could be attenuated either by the central chelation of Ca++ ions by 1.0-1.5 mM EGTA or by 30 micrograms calcineurin, a specific CaM inhibitor, when either was given ICV.	Egtazic Acid	127-131	calmodulin 1	Homo sapiens	44-47
6429475-2	1984	EGTA infusions caused an elevation of plasma PTH within 10 min.	Egtazic Acid	0-4	parathyroid hormone	Bos taurus	45-48
6429475-7	1984	The plasma PTH response to EGTA-induced hypocalcemia was not significantly altered from that observed prior to the administration of 24,25(OH)2D3.	Egtazic Acid	27-31	parathyroid hormone	Bos taurus	11-14
6429475-11	1984	The PTH response to EGTA-induced hypocalcemia was significantly reduced in these animals.	Egtazic Acid	20-24	parathyroid hormone	Bos taurus	4-7
6427979-5	1984	In the presence of EGTA, the venom inhibitor still showed the same inhibitory activity on thrombin-, sodium arachidonate-, collagen- or ionophore A23187-induced platelet aggregations triggered by successive addition of Ca2+.	Egtazic Acid	19-23	prothrombin	Oryctolagus cuniculus	90-98
6197665-7	1983	The rate of inhibition was about 50% at an E-64-a concentration of 10(-5)M. This CANP degraded selectively basic protein in myelin proteins and the degradation was inhibited by E-64-a or EGTA.	Egtazic Acid	187-191	calpain 1	Homo sapiens	81-85
6194977-1	1983	The depletion of extracellular calcium ions by EGTA abolishes the PRL stimulation of [14C]acetate incorporation into lipids in mouse mammary gland explants.	Egtazic Acid	47-51	prolactin	Mus musculus	66-69
6139089-9	1983	Both calcium transport and the (Ca2+ + Mg2+)-ATPase were significantly stimulated by the calcium-dependent regulatory protein calmodulin, especially when endogenous activator was removed by treatment with the calcium chelator ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid.	Egtazic Acid	226-290	calmodulin 2	Mus musculus	126-136
6413196-8	1983	By contrast, the TRH-induced increase was not affected by incubating cells in medium with 3 mM EGTA, or high K+, or both; incubation of cells in medium with EGTA and high K+ abolishes the electrochemical driving force for Ca2+ influx.	Egtazic Acid	157-161	thyrotropin releasing hormone	Rattus norvegicus	17-20
6419742-3	1983	Similarly, the stimulation of 2DG uptake by a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was prevented by EGTA, whereas the epidermal growth factor (EGF)-stimulated 2DG uptake was not affected by EGTA alone, but in the presence of both EGTA and A23187 which effectively depleted cellular Ca2+ content, EGF could no longer stimulate 2DG uptake.	Egtazic Acid	211-215	epidermal growth factor	Mus musculus	164-167
6419742-3	1983	Similarly, the stimulation of 2DG uptake by a tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) was prevented by EGTA, whereas the epidermal growth factor (EGF)-stimulated 2DG uptake was not affected by EGTA alone, but in the presence of both EGTA and A23187 which effectively depleted cellular Ca2+ content, EGF could no longer stimulate 2DG uptake.	Egtazic Acid	211-215	epidermal growth factor	Mus musculus	164-167
6599504-2	1983	In the erythrocyte membranes subjected to calmodulin depletion by EGTA treatment both the affinity of the Ca-pump for Ca2+ and its maximal activity in primary hypertension did not differ from normotensive controls.	Egtazic Acid	66-70	calmodulin 1	Homo sapiens	42-52
6639960-7	1983	Inhibition of factor Xa-catalyzed cleavage of a synthetic peptide was blocked by ethyleneglycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) so the inhibition was apparently dependent on divalent cations.	Egtazic Acid	81-144	coagulation factor X	Homo sapiens	14-23
6639960-7	1983	Inhibition of factor Xa-catalyzed cleavage of a synthetic peptide was blocked by ethyleneglycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) so the inhibition was apparently dependent on divalent cations.	Egtazic Acid	146-150	coagulation factor X	Homo sapiens	14-23
6414842-3	1983	The S-100 effect is greatly enhanced in the presence of physiological concentrations of K+ and is completely reversed by EGTA.	Egtazic Acid	121-125	S100 calcium binding protein A1	Homo sapiens	4-9
6315001-4	1983	The proteinase is inhibited by EGTA but not by several proteinase inhibitors.	Egtazic Acid	31-35	endogenous retrovirus group K member 18	Homo sapiens	4-14
6632011-1	1983	In a study of 27 thermally burned patients (mean TBSA, 58%; range, 32-96%) serum fibronectin levels were decreased with parallel decreased oxygen consumption of stimulated peripheral blood phagocytes and decreased EGTA-blocked burn serum opsonizing activity which correlated with serum fibronectin changes postburn.	Egtazic Acid	214-218	fibronectin 1	Homo sapiens	81-92
6628546-4	1983	This neurotensin-induced release of DA was completely abolished in calcium-free medium containing EGTA 1 mM.	Egtazic Acid	98-102	neurotensin	Rattus norvegicus	5-16
6316579-1	1983	Human platelet activation (aggregation, [14C]-5HT release and TxB2 production) induced by the phospholipids, PAF and lysophosphatidic acid (LPA) was inhibited by EGTA, TMB-8 (an intracellular calcium antagonist) and by phenylalkylamine (Class II) but not 1,4-dihydropyridine (Class I) calcium channel blockers.	Egtazic Acid	162-166	PCNA clamp associated factor	Homo sapiens	109-112
6195677-5	1983	However, the calcium chelating agent, EGTA, given ICV in a dose of 4.0-8.0 micrograms blocked the thermolytic effect of NT on body temperature in a concentration-dependent manner.	Egtazic Acid	38-42	neurotensin	Rattus norvegicus	120-122
6625605-4	1983	Recovery of progesterone receptor binding was improved by prelabeling with [3H]R5020, by adding 1.5 mM ethylene glycol bis(beta-aminoethylether)N,N"-tetraacetic acid (EGTA) to all buffers, and at high tissue concentrations.	Egtazic Acid	103-165	progesterone receptor	Rattus norvegicus	12-33
6625605-4	1983	Recovery of progesterone receptor binding was improved by prelabeling with [3H]R5020, by adding 1.5 mM ethylene glycol bis(beta-aminoethylether)N,N"-tetraacetic acid (EGTA) to all buffers, and at high tissue concentrations.	Egtazic Acid	167-171	progesterone receptor	Rattus norvegicus	12-33
6313451-2	1983	At variance with this mechanism, potassium-evoked parathyroid hormone (PTH) release from perifused dispersed bovine parathyroid cells also occurred in calcium-free medium containing 1 mM EGTA.	Egtazic Acid	187-191	parathyroid hormone	Bos taurus	50-69
6640432-4	1983	Exclusion of CaCl2 from the medium (plus 0.1 mM EGTA) significantly reduced (p less than 0.025) PGE output in CS and SL cells (83 +/- 22 and 183 +/- 47, respectively) and PGF output in CS cells (70 +/- 17).	Egtazic Acid	48-52	placental growth factor	Homo sapiens	171-174
6631732-6	1983	In a Ca-free solution containing 1 mM-EGTA (Ca-free standard solution), 10(-6) M-BK caused a slight contraction even after high-K-induced contractions were completely blocked.	Egtazic Acid	38-42	kininogen 1	Bos taurus	81-83
6191780-6	1983	Addition of 200 nM calmodulin to membranes, in which endogenous calmodulin was decreased from 1.4 microgram/mg protein to 0.5 microgram/mg protein by washing with buffer containing EGTA and EDTA, resulted in a 3-4-fold increase of adenylate cyclase activity.	Egtazic Acid	181-185	calmodulin-3	Cavia porcellus	19-29
6313075-6	1983	During chromatography of phosphodiesterase on calmodulin-Sepharose the enzyme was eluted from the column both in the presence of EGTA and palmitic acid.	Egtazic Acid	129-133	calmodulin 1	Homo sapiens	46-56
6410926-9	1983	EGTA (1mM) prevented all of the insulin effects, whereas the calcium ionophore A-23187 (2 microM) augmented the hormone actions.	Egtazic Acid	0-4	insulin	Homo sapiens	32-39
6409584-5	1983	PTH increased within 2 h (P less than 0.05) and remained elevated (P less than 0.05) for up to 2 h after the end of the EGTA infusions, whereas Pin and Mg were not significantly changed.	Egtazic Acid	120-124	parathyroid hormone	Homo sapiens	0-3
6311250-1	1983	Calmodulin-dependent protein phosphatase, one of the major calmodulin-binding proteins in bovine brain, dephosphorylates casein with a specific activity of 15 nmol mg-1 min-1 at 30 degrees C. The stimulation of phosphatase activity by calmodulin is reversed by ethylene glycol bis (beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid or trifluoperazine, a calmodulin antagonist.	Egtazic Acid	261-331	calmodulin 1	Rattus norvegicus	0-10
6191780-6	1983	Addition of 200 nM calmodulin to membranes, in which endogenous calmodulin was decreased from 1.4 microgram/mg protein to 0.5 microgram/mg protein by washing with buffer containing EGTA and EDTA, resulted in a 3-4-fold increase of adenylate cyclase activity.	Egtazic Acid	181-185	calmodulin-3	Cavia porcellus	64-74
6225427-3	1983	When this calmodulin was partially removed by EGTA treatment (0.5 mM-EGTA), the uptake of 45Ca2+ by the microsomal vesicles was stimulated by added calmodulin and inhibited by trifluoperazine (TFP).	Egtazic Acid	46-50	calmodulin 1	Homo sapiens	10-20
6225427-3	1983	When this calmodulin was partially removed by EGTA treatment (0.5 mM-EGTA), the uptake of 45Ca2+ by the microsomal vesicles was stimulated by added calmodulin and inhibited by trifluoperazine (TFP).	Egtazic Acid	46-50	calmodulin 1	Homo sapiens	148-158
6225427-3	1983	When this calmodulin was partially removed by EGTA treatment (0.5 mM-EGTA), the uptake of 45Ca2+ by the microsomal vesicles was stimulated by added calmodulin and inhibited by trifluoperazine (TFP).	Egtazic Acid	69-73	calmodulin 1	Homo sapiens	10-20
6225427-3	1983	When this calmodulin was partially removed by EGTA treatment (0.5 mM-EGTA), the uptake of 45Ca2+ by the microsomal vesicles was stimulated by added calmodulin and inhibited by trifluoperazine (TFP).	Egtazic Acid	69-73	calmodulin 1	Homo sapiens	148-158
6404633-10	1983	The addition of EGTA in the membrane-washing solution results in decrease of the membrane-found pool calmodulin up to 0.01 mumol/l of cells (membranes B).	Egtazic Acid	16-20	calmodulin 1	Rattus norvegicus	101-111
6222912-7	1983	The EGTA-resistant substratum-attached material on PF4 was morphologically similar to that on FN, the latter of which was derived from both tight focal contacts and discrete specializations within certain close contacts.	Egtazic Acid	4-8	platelet factor 4	Homo sapiens	51-54
6222912-7	1983	The EGTA-resistant substratum-attached material on PF4 was morphologically similar to that on FN, the latter of which was derived from both tight focal contacts and discrete specializations within certain close contacts.	Egtazic Acid	4-8	fibronectin 1	Homo sapiens	94-96
6604155-9	1983	A Ca2+ transient could be evoked in Ca2+-free Ringer solution containing EGTA.	Egtazic Acid	73-77	carbonic anhydrase 2	Homo sapiens	2-5
6604155-9	1983	A Ca2+ transient could be evoked in Ca2+-free Ringer solution containing EGTA.	Egtazic Acid	73-77	carbonic anhydrase 2	Homo sapiens	36-39
6576338-3	1983	By glycerol gradient centrifugation, the native enzyme has a s20,w of 4.5 S in EGTA and 5 S in the presence of Ca2+-calmodulin.	Egtazic Acid	79-83	calmodulin 1	Homo sapiens	116-126
6310816-1	1983	Collagen gel retraction (CGR) and thrombin-induced fibrin clot retraction (FCR) could be abolished by EGTA and EDTA, trifluoperazine - a calmodulin inhibitor - and by NEM.	Egtazic Acid	102-106	coagulation factor II, thrombin	Homo sapiens	34-42
6406505-2	1983	The binding of EDTA and EGTA to bovine alpha-lactalbumin was shown to stabilize the native conformation relative to that characteristic of the metal-free protein (A conformer).	Egtazic Acid	24-28	lactalbumin alpha	Bos taurus	39-56
6404633-13	1983	The effect of EGTA treatment (membranes B) on the affinity of Ca-pump to Ca is abolished after addition of micromolar concentrations of calmodulin or millimolar concentration of EGTA in the incubation medium.	Egtazic Acid	14-18	calmodulin 1	Rattus norvegicus	136-146
6871664-8	1983	Drugs that increase cyclic nucleotide levels in cells (cholera toxin, RO 20-1724, monobutyryl cyclic AMP, monobutyryl cyclic GMP) block the NAT decrease by light, whereas high potassium or EGTA do not block this light-induced NAT inactivation.	Egtazic Acid	189-193	arylamine N-acetyltransferase, liver isozyme	Gallus gallus	140-143
6404633-14	1983	The increase of EGTA concentration in the incubation medium results in decrease of the affinity of Ca-pump to calmodulin.	Egtazic Acid	16-20	calmodulin 1	Rattus norvegicus	110-120
6404633-19	1983	(b) The tightly bound pool of calmodulin which is removed by EGTA treatment determines the affinity of Ca-pump to Ca.	Egtazic Acid	61-65	calmodulin 1	Rattus norvegicus	30-40
6303033-4	1983	On the other hand, the removal of calcium by 10 mM EGTA washing of the microsomes caused a marked reduction of glucose-6-phosphatase activity raised by CT administration.	Egtazic Acid	51-55	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	111-132
6403530-5	1983	With EGTA present to chelate any residual Ca2+, prolactin mRNA was not detectably increased by TRH, showing that TRH requires Ca2+ to stimulate prolactin mRNA.	Egtazic Acid	5-9	thyrotropin releasing hormone	Rattus norvegicus	113-116
6302705-6	1983	For PC12 cells, these responses to replacement of NGF could not be mimicked by addition of dibutyryl cAMP (less than or equal to 2 mM) or the Ca2+ ionophore A23187 (less than or equal to 5 microM) to NGF-deprived cultures nor inhibited by the presence of EGTA (less than or equal to 2 mM) or calcium antagonists in the culture medium.	Egtazic Acid	255-259	nerve growth factor	Rattus norvegicus	50-53
6131899-11	1983	Furthermore, the concentration of EGTA routinely employed to maintain free Ca2+ levels may itself obscure effects of calmodulin and other physiological agents on calcium-dependent activities.	Egtazic Acid	34-38	calmodulin 1	Homo sapiens	117-127
6303033-4	1983	On the other hand, the removal of calcium by 10 mM EGTA washing of the microsomes caused a marked reduction of glucose-6-phosphatase activity raised by CT administration.	Egtazic Acid	51-55	calcitonin-related polypeptide alpha	Rattus norvegicus	152-154
6312252-3	1983	Reductions in PTH secretion were found at all concentrations of Ca++ tested between 0.3 mM and 2.0 mM and in the presence of the divalent cation chelators EDTA and EGTA, indicating that extracellular Ca++ is not an absolute requirement for the inhibition.	Egtazic Acid	164-168	parathyroid hormone	Bos taurus	14-17
6573655-10	1983	Active L-CAM derivatives released by trypsin in the presence of EGTA were detected as a species of M(r) 40,000.	Egtazic Acid	64-68	cadherin 1	Gallus gallus	7-12
6297610-6	1983	This action of calmodulin did not require Ca2+ for activation of the enzyme; and activation occurred in the presence of EGTA.	Egtazic Acid	120-124	calmodulin 1	Homo sapiens	15-25
6401247-3	1983	The influence of verapamil, LaCl3, A23187, and EGTA on the release of gastrin by luminal calcium and ethyl alcohol was examined and the release of immunoreactive gastrin (IG) was measured in luminal perfusates.	Egtazic Acid	47-51	gastrin	Canis lupus familiaris	70-77
6181205-2	1982	Solubilization of myelin with 0.4% Triton X-100 plus 4 mM EGTA, with or without further fractionation, showed that Ca2+-dependent phosphorylation of MBP required phosphatidylserine, but not calmodulin.	Egtazic Acid	58-62	myelin basic protein	Rattus norvegicus	149-152
7162027-3	1982	Differences in the rates of calcium transport through EGTA-treated membranes were only detectable in the presence of exogenous calmodulin.	Egtazic Acid	54-58	calmodulin 1	Homo sapiens	127-137
20487936-2	1983	Brain is especially rich in calmodulin, containing about 400 mg (24 ?mol) of EGTA-extractable calmodulin per kg of brain.	Egtazic Acid	77-81	calmodulin 1	Homo sapiens	28-38
20487936-2	1983	Brain is especially rich in calmodulin, containing about 400 mg (24 ?mol) of EGTA-extractable calmodulin per kg of brain.	Egtazic Acid	77-81	calmodulin 1	Homo sapiens	94-104
6812433-5	1982	The decrease in fluorescence elicited by TRH was specific for Ca2+-CTC complexes because preincubation of the cells with 1 mM EGTA or 1 mM EDTA plus 2.05 mM Mg2+ abolished the response, whereas preincubation with 1 mM EDTA plus 2.05 mM Ca2+ permitted the usual TRH response.	Egtazic Acid	126-130	thyrotropin releasing hormone	Mus musculus	41-44
7138883-1	1982	Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively.	Egtazic Acid	62-66	plasminogen	Homo sapiens	0-7
7138883-1	1982	Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively.	Egtazic Acid	62-66	fibrinogen beta chain	Homo sapiens	21-31
7171560-5	1982	Additional calmodulin binding sites were not produced by further ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) treatment of membranes prepared in the presence of ethylenediaminetetraacetic acid (EDTA).	Egtazic Acid	136-140	calmodulin 1	Rattus norvegicus	11-21
6812433-5	1982	The decrease in fluorescence elicited by TRH was specific for Ca2+-CTC complexes because preincubation of the cells with 1 mM EGTA or 1 mM EDTA plus 2.05 mM Mg2+ abolished the response, whereas preincubation with 1 mM EDTA plus 2.05 mM Ca2+ permitted the usual TRH response.	Egtazic Acid	126-130	thyrotropin releasing hormone	Mus musculus	261-264
7138883-1	1982	Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively.	Egtazic Acid	139-143	plasminogen	Homo sapiens	0-7
6804463-2	1982	In the absence of MAPs, calmodulin enhances the rate and extent of polymerization of pure tubulin, probably by sequestering Ca2+ from tubulin since the effect is mimicked by ethylene glycol bis(beta-aminoethyl ether)N,N,N",N"-tetraacetic acid and parvalbumin.	Egtazic Acid	174-242	calmodulin	Bos taurus	24-34
7138883-1	1982	Plasmin digestion of fibrinogen in the presence of Ca2+ or of EGTA leads to the formation of two sets of fragments, designated Dcate and D EGTA, respectively.	Egtazic Acid	139-143	fibrinogen beta chain	Homo sapiens	21-31
7174634-1	1982	Although calmodulin is generally regarded as a soluble protein, a considerable amount of calmodulin activity was found to be associated with particulate fractions of mammalian tissues after an extensive washing of the particulate fraction with EGTA.	Egtazic Acid	244-248	calmodulin 1	Homo sapiens	89-99
7174634-2	1982	Identity of this particle-bound and EGTA-nonextractable form of calmodulin with soluble calmodulin was established recently (Sobue, K., Yamazaki, R., Yasuda, S., &amp; Kakiuchi, S. (1981) FEBS Lett.	Egtazic Acid	36-40	calmodulin 1	Homo sapiens	64-74
7174634-2	1982	Identity of this particle-bound and EGTA-nonextractable form of calmodulin with soluble calmodulin was established recently (Sobue, K., Yamazaki, R., Yasuda, S., &amp; Kakiuchi, S. (1981) FEBS Lett.	Egtazic Acid	36-40	calmodulin 1	Homo sapiens	88-98
7119792-7	1982	This dependence could only be demonstrated after successive washing of the membranes with EGTA buffers, a procedure designed to remove endogenous calmodulin.	Egtazic Acid	90-94	calmodulin	Bos taurus	146-156
6214277-5	1982	Calmodulin and phenothiazines have no effect on calcium accumulation in freshly prepared membranes, but small effects are inducible after a wash with a 5 mM EGTA.	Egtazic Acid	157-161	calmodulin 1	Rattus norvegicus	0-10
6807107-5	1982	Addition of 10(-4) M EGTA to media containing no added Ca2+ lowered basal incorporation, abolished CCK"s stimulatory effect and enhanced its inhibitory effect.	Egtazic Acid	21-25	cholecystokinin	Rattus norvegicus	99-102
7182181-4	1982	The removal of calcium by 1 mM EGTA treatment of the hepatic particulate glycogen caused a clear reduction in the increase in phosphorylase a activity produced by CT administration.	Egtazic Acid	31-35	calcitonin-related polypeptide alpha	Rattus norvegicus	163-165
7182181-5	1982	Meanwhile, the enzyme activity in 1 mM EGTA-treated particulate glycogen of the liver in both control and CT (80 MRC mU/100 g BW)-treated rats was significantly enhanced by the addition of calcium ion (10 microM).	Egtazic Acid	39-43	calcitonin-related polypeptide alpha	Rattus norvegicus	106-108
6179567-4	1982	Inhibition of AXT was achieved by incubating Triton X-100-treated nerves in CMFR + EGTA for 5 h, followed by an additional incubation for 12 h in CMFR or Ringer"s devoid of only Ca2+ (CFR).	Egtazic Acid	83-87	contactin 2	Homo sapiens	14-17
7202016-3	1982	The binding of calmodulin to fluphenazine, perphenazine and 7-aminotriflupromazine involved on the one hand non-specific electrostatic interactions which are abolished by increasing the eluent salt concentration, and on the other hand, Ca2+-dependent interactions which are reversed by EGTA addition.	Egtazic Acid	286-290	calmodulin 1	Homo sapiens	15-25
6122723-6	1982	A 30,000 Mr protein doublet purified from coated vesicles was completely eluted by EGTA from the calmodulin affinity column, confirming that this protein doublet represents one of the coated vesicle calmodulin binding sites.	Egtazic Acid	83-87	calmodulin 1	Homo sapiens	97-107
6282932-5	1982	The thrombin effects on binding of 125I-F. VIIIVWF was not observed when platelets were washed with EDTA-containing buffers; EDTA and EGTA both inhibited thrombin-induced binding.	Egtazic Acid	134-138	coagulation factor II, thrombin	Homo sapiens	4-12
6282932-5	1982	The thrombin effects on binding of 125I-F. VIIIVWF was not observed when platelets were washed with EDTA-containing buffers; EDTA and EGTA both inhibited thrombin-induced binding.	Egtazic Acid	134-138	coagulation factor II, thrombin	Homo sapiens	154-162
6122723-6	1982	A 30,000 Mr protein doublet purified from coated vesicles was completely eluted by EGTA from the calmodulin affinity column, confirming that this protein doublet represents one of the coated vesicle calmodulin binding sites.	Egtazic Acid	83-87	calmodulin 1	Homo sapiens	199-209
6281099-3	1982	Gradual lowering of the extracellular Ca2+ levels produced a concentration-dependent inhibition of the alpha-MSH response; complete inhibition was obtained in a Ca2+-free medium containing 10-4 M EGTA.	Egtazic Acid	196-200	proopiomelanocortin S homeolog	Xenopus laevis	103-112
6805332-8	1982	K"Ca was found to be 2.45 +/- 0.04 X 10(6) M-1 in 100 mM KCl, 10 mM N-2-hydroxyethylpiperazine-N"-2-ethanesulfonic acid, and 1 mM EGTA at pH 7.00 and 23 degrees C. Total [EGTA] varied with supplier but was always less than quoted.	Egtazic Acid	130-134	casein kappa	Homo sapiens	0-4
6805332-8	1982	K"Ca was found to be 2.45 +/- 0.04 X 10(6) M-1 in 100 mM KCl, 10 mM N-2-hydroxyethylpiperazine-N"-2-ethanesulfonic acid, and 1 mM EGTA at pH 7.00 and 23 degrees C. Total [EGTA] varied with supplier but was always less than quoted.	Egtazic Acid	171-175	casein kappa	Homo sapiens	0-4
6799504-3	1982	Phosphorylation was enhanced when purified sarcoplasmic reticulum vesicles were extracted with 1 mM ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid at pH 8.0 to remove endogenous calmodulin and lower the level of residual phosphorylation.	Egtazic Acid	100-169	calmodulin 1	Homo sapiens	201-211
6177320-5	1982	However, in the presence of EGTA, papaverine inhibition of cyclic GMP but not cyclic AMP phosphodiesterase was reduced significantly.	Egtazic Acid	28-32	5'-nucleotidase, cytosolic II	Homo sapiens	66-69
6177320-7	1982	With imidazolidinone analogues (Ro 7-2956 and Ro 20-1724), EGTA enhanced the inhibition of cyclic GMP phosphodiesterase without significantly altering the inhibition of cyclic AMP phosphodiesterase.	Egtazic Acid	59-63	5'-nucleotidase, cytosolic II	Homo sapiens	98-101
6177320-8	1982	Inhibition of cyclic AMP of cyclic GMP phosphodiesterase activity by 1-methyl-3-isobutylxanthine, quinidine, or compound SQ 20,009 was not affected appreciably by calcium or EGTA.	Egtazic Acid	174-178	5'-nucleotidase, cytosolic II	Homo sapiens	35-38
7096288-3	1982	Within the physiological pH range, the specific binding, defined as the amount of bound [3H]calmodulin which is displacable by the addition of an excess of unlabeled calmodulin, agreed well with the Ca2+-dependent binding defined as the difference between the total binding in the presence of Ca2+ and the binding obtained with EGTA in place of Ca2+.	Egtazic Acid	328-332	calmodulin 1	Homo sapiens	92-102
6803388-5	1982	Second, EDTA, EGTA, db-AMPc, p"-bromophenacylbromide and 874 CB, which, in spite of their structural diversity, are all PLA2 blockers, inhibited the release of both PAF-acether and of the lyso-compound.	Egtazic Acid	14-18	phospholipase A2	Oryctolagus cuniculus	120-124
6799504-11	1982	A functional role for the phosphorylation system is suggested by the observations that ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid extraction, which removes endogenous calmodulin and lowers endogenous phosphorylation levels, and high pH, which inhibits phosphorylation, lead to greatly diminished Ca2+ accumulation by sarcoplasmic reticulum vesicles.	Egtazic Acid	87-156	calmodulin 1	Homo sapiens	194-204
6272849-9	1981	When incubating the isolated epithelial cells in an EGTA-containing CA2+-free medium, bovine PTH lost its capacity to inhibit oKNa.	Egtazic Acid	52-56	parathyroid hormone	Bos taurus	93-96
7152549-1	1982	125I-labelled dinitrophenylated human serum albumin (DNP35HSA) was shown to form large aggregates after incubation either in normal human serum (NHS) containing ethylene diamine tetraacetate (EDTA), or in heat treated NHS, whereas much smaller aggregates were formed after incubation in NHS or NHS containing ethylene glycol tetraacetate (EGTA) and Mg2+.	Egtazic Acid	339-343	albumin	Homo sapiens	38-51
7085778-3	1982	The ligatin-hydrolase complexes subsequently can be dissociated with ethyleneglycol-bis(beta-amino-ethyl ether) N, N"-tetraacetic acid, resulting in a concurrent depolymerization of the ligatin filament.	Egtazic Acid	69-134	ligatin	Homo sapiens	4-11
7085778-3	1982	The ligatin-hydrolase complexes subsequently can be dissociated with ethyleneglycol-bis(beta-amino-ethyl ether) N, N"-tetraacetic acid, resulting in a concurrent depolymerization of the ligatin filament.	Egtazic Acid	69-134	ligatin	Homo sapiens	186-193
6805461-1	1981	Adenylate cyclase activity in the rat lung membranes washed with 150 microM-EGTA was stimulated by calmodulin in the presence of 100 microM-Ca2+.	Egtazic Acid	76-80	calmodulin 1	Rattus norvegicus	99-109
6275716-1	1981	Vasopressin (AVP stimulated immunoreactive E (iPGE) synthesis and the release of [3H]arachidonate (AA) from prelabeled slices of rat inner medulla (IM) in the presence but not in the absence of Ca2+ (plus 2 mM EGTA).	Egtazic Acid	210-214	arginine vasopressin	Rattus norvegicus	0-11
7060128-3	1982	This inhibitory effect of Fab is removed when anti-TC-F9 is absorbed with F9 cells treated with trypsin and calcium (TC-F9), but not when it is absorbed with F9 cells treated with trypsin and EGTA (TE-F9).	Egtazic Acid	192-196	FA complementation group B	Homo sapiens	26-29
6809899-5	1982	Cells grown in the presence of 1.85 mM-EGTA showed a two-to threefold increase in GM3 whereas other glycosphingolipids were only slightly affected.	Egtazic Acid	39-43	granulocyte macrophage antigen 3	Mus musculus	82-85
6809899-6	1982	When cells were grown in the presence of 1.45 mM-EGTA plus 0.4 mM-EDTA a similar increase in GM3 was observed but this change was now accompanied by decreases in GM2, GM1, GgOse3Cer.	Egtazic Acid	49-53	granulocyte macrophage antigen 3	Mus musculus	93-96
6809899-6	1982	When cells were grown in the presence of 1.45 mM-EGTA plus 0.4 mM-EDTA a similar increase in GM3 was observed but this change was now accompanied by decreases in GM2, GM1, GgOse3Cer.	Egtazic Acid	49-53	cytochrome b5 domain containing 2	Mus musculus	162-165
7054638-6	1982	This neurotensin-induced release of NA was completely abolished in calcium free medium containing EGTA 1 mM.	Egtazic Acid	98-102	neurotensin	Rattus norvegicus	5-16
6895374-6	1981	The fluorescence increase produced by calmodulin binding to myosin light chain kinase is completely reversed by ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid at a rate of approximately 2 s-1.	Egtazic Acid	112-181	calmodulin 1	Homo sapiens	38-48
6895374-6	1981	The fluorescence increase produced by calmodulin binding to myosin light chain kinase is completely reversed by ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid at a rate of approximately 2 s-1.	Egtazic Acid	112-181	myosin light chain kinase	Homo sapiens	60-85
6213404-5	1981	The removal of calcium by 10 mM EGTA washing of the mitochondria produced a remarkable reduction in pyruvate carboxylase activity increased by CT administration.	Egtazic Acid	32-36	pyruvate carboxylase	Rattus norvegicus	100-120
6213404-5	1981	The removal of calcium by 10 mM EGTA washing of the mitochondria produced a remarkable reduction in pyruvate carboxylase activity increased by CT administration.	Egtazic Acid	32-36	calcitonin-related polypeptide alpha	Rattus norvegicus	143-145
7338726-8	1981	Spermatozoa suspended in medium TNC lose motility rapidly on addition of EGTA in excess of the Ca+2 present.	Egtazic Acid	73-77	tenascin C	Mus musculus	32-35
6453867-12	1981	Both Ca transport and the Ca-ATPase activity of ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid-treated lymphocyte plasma membranes were stimulated 2-fold by a cytoplasmic component (calmodulin) that was purified 500-fold from lymphocyte cytoplasm.	Egtazic Acid	48-117	dynein axonemal heavy chain 8	Homo sapiens	29-35
7317523-5	1981	The external pathway of NADH oxidation in liver mitochondria is sensitive to the inhibitors of phospholipase A2 (nupercaine, EGTA) and the inhibitor of lipid peroxidation (ionole).	Egtazic Acid	125-129	phospholipase A2 group IB	Homo sapiens	95-111
6270154-4	1981	When calmodulin extensively dialyzed against EGTA, this stimulation is abolished.	Egtazic Acid	45-49	calmodulin 2	Mus musculus	5-15
6455157-3	1981	The effect of EGTA differed from that of calmodulin, as it increased Ca2+ affinity without increasing V. EGTA also increased the apparent Ca2+ affinity when calmodulin was present in the assay medium.	Egtazic Acid	14-18	calmodulin 1	Homo sapiens	157-167
6455157-3	1981	The effect of EGTA differed from that of calmodulin, as it increased Ca2+ affinity without increasing V. EGTA also increased the apparent Ca2+ affinity when calmodulin was present in the assay medium.	Egtazic Acid	105-109	calmodulin 1	Homo sapiens	157-167
6172119-4	1981	The addition of EGTA (1.27-2.0mm) to chelate residual extracellular Ca(2+) further decreased hormone-induced rises in ornithine decarboxylase activity.	Egtazic Acid	16-20	ornithine decarboxylase 1	Sus scrofa	118-141
7251661-8	1981	The calmodulin dependency of the reaction was further strengthened by the observed inhibition of the calmodulin-activatable phosphorylation, but not of the Mg(2+)-dependent activity, by the Ca(2+) chelator, EGTA, which also removes the calmodulin from the structure (26), and by the binding to calmodulin of the antipsychotic drug chlorpromazine in the presence of Ca(2+).	Egtazic Acid	207-211	calmodulin 1	Homo sapiens	4-14
6265467-6	1981	Binding of iodinated calmodulin to these proteins was blocked by EDTA, EGTA, chlorpromazine, and preincubation with unlabeled calmodulin.	Egtazic Acid	71-75	calmodulin 1	Homo sapiens	21-31
6455156-2	1981	Calmodulin enhanced 2.5-fold 45Ca accumulation by EGTA-treated microsomes incubated with 10 microM Ca2+ (in the absence of oxalate) by increasing markedly the apparent affinity of the transport system for Ca2+.	Egtazic Acid	50-54	calmodulin 1	Rattus norvegicus	0-10
7251661-8	1981	The calmodulin dependency of the reaction was further strengthened by the observed inhibition of the calmodulin-activatable phosphorylation, but not of the Mg(2+)-dependent activity, by the Ca(2+) chelator, EGTA, which also removes the calmodulin from the structure (26), and by the binding to calmodulin of the antipsychotic drug chlorpromazine in the presence of Ca(2+).	Egtazic Acid	207-211	calmodulin 1	Homo sapiens	101-111
7251661-8	1981	The calmodulin dependency of the reaction was further strengthened by the observed inhibition of the calmodulin-activatable phosphorylation, but not of the Mg(2+)-dependent activity, by the Ca(2+) chelator, EGTA, which also removes the calmodulin from the structure (26), and by the binding to calmodulin of the antipsychotic drug chlorpromazine in the presence of Ca(2+).	Egtazic Acid	207-211	calmodulin 1	Homo sapiens	101-111
7251661-8	1981	The calmodulin dependency of the reaction was further strengthened by the observed inhibition of the calmodulin-activatable phosphorylation, but not of the Mg(2+)-dependent activity, by the Ca(2+) chelator, EGTA, which also removes the calmodulin from the structure (26), and by the binding to calmodulin of the antipsychotic drug chlorpromazine in the presence of Ca(2+).	Egtazic Acid	207-211	calmodulin 1	Homo sapiens	101-111
6786106-2	1981	Explants exposed for 2 h to calcium-poor medium or medium containing either 2 mM EDTA or 2 mM EGTA released 160, 248, and 253% more hPL, respectively, than control explants.	Egtazic Acid	94-98	galectin 1	Homo sapiens	132-135
6895466-4	1981	In the presence of EGTA, troponin C was digested by thrombin to yield three peptides, TH1 (residues 1--120), TH3 (residues 1--100) and TH2 (residues 121--159).	Egtazic Acid	19-23	coagulation factor II, thrombin	Homo sapiens	52-60
6263103-2	1981	LH release during continuous stimulation with GnRH (10(-7) M) was inhibited by EGTA (1.5 or 5 mM given 1 h prior to GnRH) or by D-600 (methoxyverapamil, 1 mM, given concomitantly with GnRH).	Egtazic Acid	79-83	gonadotropin releasing hormone 1	Rattus norvegicus	46-50
6895466-4	1981	In the presence of EGTA, troponin C was digested by thrombin to yield three peptides, TH1 (residues 1--120), TH3 (residues 1--100) and TH2 (residues 121--159).	Egtazic Acid	19-23	negative elongation factor complex member C/D	Homo sapiens	86-89
6895466-6	1981	In the presence of EGTA calmodulin was digested by thrombin giving two peptides, TM1 (residues 1--106) and TM2 (residues 107--148).	Egtazic Acid	19-23	calmodulin 1	Homo sapiens	24-34
6895466-6	1981	In the presence of EGTA calmodulin was digested by thrombin giving two peptides, TM1 (residues 1--106) and TM2 (residues 107--148).	Egtazic Acid	19-23	coagulation factor II, thrombin	Homo sapiens	51-59
6788415-14	1981	Intracellular Ca2+ stores may be depleted by treatment with EGTA, or by repeated drug additions in the absence of extracellular calcium.	Egtazic Acid	60-64	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	14-17
7012126-10	1981	We conclude that under the influence of EGTA colicin M is removed from its site of action and becomes again accessible to trypsin at the cell surface.	Egtazic Acid	40-44	Colicin-M	Escherichia coli	45-54
6458279-9	1981	In the absence of Ca(2+)/EGTA buffer the biphasic Ca(2+)-binding affinity of myosin is twice as high at pH7.4 (site one: 1.2x10(6)m(-1) and site two: 0.4x10(6)m(-1)) as compared with values obtained at pH6.5 (site one: 0.64x10(6)m(-1) and site two: 0.2x10(6)m(-1)).	Egtazic Acid	25-29	myosin heavy chain 14	Homo sapiens	77-83
6162654-5	1981	As with 48/80, this response to somatostatin was inhibited by treating the mast cells with EDTA or EGTA or by exposing them briefly to A23187 in calcium-free media, all of which procedures seemingly deplete cellular calcium stores.	Egtazic Acid	99-103	somatostatin	Homo sapiens	32-44
6267261-2	1981	A vaseline-gap voltage-clamp technique was used to record slow Ca2+ and K+ currents from frog skeletal muscle fibres loaded with the Ca2+ chelator EGTA.	Egtazic Acid	147-151	carbonic anhydrase 2	Homo sapiens	133-136
6108962-9	1981	Much of this calmodulin could not be extracted even by washing with 1 mM EGTA and/or 0.1% (w/v) Triton X-100.	Egtazic Acid	73-77	calmodulin 1	Rattus norvegicus	13-23
7305948-2	1981	Mouse C1q, a subcomponent of the first component of complement, has been purified in a highly haemolytically active form by a combination of precipitation with EGTA, ion-exchange chromatography and gel filtration.	Egtazic Acid	160-164	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	6-9
7460825-6	1981	This protein, which can be released into the supernatant by the pretreatment of GH1 cells with EGTA, is an absolute requirement for chlorpromazine stimulation of adenylate cyclase activity in these cells.	Egtazic Acid	95-99	growth hormone 1	Rattus norvegicus	80-83
6260201-8	1981	From sucrose gradient studies we demonstrated that in the presence of Ca2+ the amount of calmodulin bound to phosphorylase kinase was enhanced, compared to the control in the presence of EGTA.	Egtazic Acid	187-191	calmodulin 2	Mus musculus	89-99
6272722-4	1981	On the other hand, removal of intracellular Ca2+ with the ionophore A23187 and EGTA increased the amount of phosphatidylinositol.	Egtazic Acid	79-83	carbonic anhydrase 2	Oryctolagus cuniculus	44-47
6786910-0	1981	Altered burst responses in hippocampal CA3 neurons injected with EGTA.	Egtazic Acid	65-69	carbonic anhydrase 3	Homo sapiens	39-42
6786910-1	1981	Intracellular injection of EGTA abolished the hyperpolarization seen after spontaneous and evoked bursts of action potentials in hippocampal CA3 neurons.	Egtazic Acid	27-31	carbonic anhydrase 3	Homo sapiens	141-144
6108784-10	1980	Arrhenius plots of ESR spectral parameters suggest a conformational transition in both membranous and solubilized ATPases at about 22 degrees C. The transition was also present in EGTA-, but not in heat-inactivated ATPase.	Egtazic Acid	180-184	dynein axonemal heavy chain 8	Homo sapiens	114-120
6804372-1	1981	The complement component Clq, prepared by euglobulin precipitation of serum to which EDTA or EGTA had been added, contained fibronectin (FN) as detected by radioimmunoassay and immunodiffusion methods.	Egtazic Acid	93-97	fibronectin 1	Homo sapiens	124-135
6254958-4	1980	The interaction between TNS and purified bovine brain calmodulin as demonstrated in the appearance of TNS fluorescence in the presence of 3 microM or more of calcium ion was not observed in the presence of 2 mM EGTA.	Egtazic Acid	211-215	calmodulin	Bos taurus	54-64
6780450-4	1981	For this purpose, increasing concentrations of Ca2+ chelators (EGTA and EDTA) were added to cultures in order to compare the effect of progressive extracellular Ca2+ (Ca2+EC) depletion on [3H]-Tdr incorporation by PHA-PBL.	Egtazic Acid	63-67	carbonic anhydrase 2	Homo sapiens	47-50
6780450-7	1981	They also required larger amounts of Ca2+ supplements to restore their normal response after total inhibition by EGTA.	Egtazic Acid	113-117	carbonic anhydrase 2	Homo sapiens	37-40
6778918-3	1981	Prior absorption of normal human serum (NHS) or C2-deficient human serum (C2D) with zymosan at 0 degrees C results in diminished consumption of C3 and factor B during subsequent incubation of the sera in Mg-EGTA buffer with zymosan at 37 degrees C for 30 min.	Egtazic Acid	207-211	complement C3	Homo sapiens	144-159
6108784-11	1980	Although SH reactivity of monomeric  ATPase was dramatically enhanced by EGTA inactivation, the results of ESR, circular dichroism and analytical ultracentrifugation experiments indicate limited conformational changes induced by EGTA treatment.	Egtazic Acid	73-77	dynein axonemal heavy chain 8	Homo sapiens	37-43
6108784-11	1980	Although SH reactivity of monomeric  ATPase was dramatically enhanced by EGTA inactivation, the results of ESR, circular dichroism and analytical ultracentrifugation experiments indicate limited conformational changes induced by EGTA treatment.	Egtazic Acid	229-233	dynein axonemal heavy chain 8	Homo sapiens	37-43
6970196-1	1980	Bovine complement subcomponent C1q was purified, in a highly hemolytically active form, by a combination of precipitation with EGTA, ion-exchange chromatography, and gel filtration.	Egtazic Acid	127-131	complement C1q A chain	Homo sapiens	31-34
6253285-10	1980	In the presence of EGTA, calmodulin-activated phosphodiesterase eluted at 0.13 M NaCl, while calmodulin eluted between 0.25-0.4 M NaCl.	Egtazic Acid	19-23	calmodulin	Bos taurus	25-35
6253285-10	1980	In the presence of EGTA, calmodulin-activated phosphodiesterase eluted at 0.13 M NaCl, while calmodulin eluted between 0.25-0.4 M NaCl.	Egtazic Acid	19-23	calmodulin	Bos taurus	93-103
6450771-4	1980	Both alkaline phosphatase and Ca2+ ATPase, when treated with EGTA, required Ca2+ for the restoration of activity.	Egtazic Acid	61-65	carbonic anhydrase 2	Homo sapiens	30-41
6773954-7	1980	Both procedures showed that calmodulin methyltransferase is inhibited by EGTA and stimulated by divalent cations, with manganese giving the highest activity.	Egtazic Acid	73-77	calmodulin 1	Rattus norvegicus	28-38
6777459-2	1980	Inward calcium currents were eliminated by using Co2+, Cd2+, or OCa2+ EGTA in the bathing solution.	Egtazic Acid	70-74	OCA2 melanosomal transmembrane protein	Homo sapiens	64-68
7452489-1	1980	A calmodulin-binding assay was established in rat striatal particulates which were depleted of endogenous calcium and calmodulin by ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) treatment.	Egtazic Acid	132-196	calmodulin 1	Rattus norvegicus	2-12
7452489-1	1980	A calmodulin-binding assay was established in rat striatal particulates which were depleted of endogenous calcium and calmodulin by ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) treatment.	Egtazic Acid	132-196	calmodulin 1	Rattus norvegicus	118-128
7452489-1	1980	A calmodulin-binding assay was established in rat striatal particulates which were depleted of endogenous calcium and calmodulin by ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) treatment.	Egtazic Acid	198-202	calmodulin 1	Rattus norvegicus	2-12
6251127-4	1980	Metrizamide caused enhanced conversion of C3 and factor B that was only partially inhibited by ethylene glycol tetracetic acid (EGTA) but completely inhibited by ethylenediaminetetraacetic acid (EDTA).	Egtazic Acid	128-132	complement C3	Homo sapiens	42-57
6105882-6	1980	The low level of (Ca2+ + Mg2+)-ATPase activity seen at high Ca2+ concentration can be augmented by lowering the Ca2+ concentration of EGTA in the assay medium.	Egtazic Acid	134-138	dynein axonemal heavy chain 8	Homo sapiens	31-37
6777224-3	1980	In calcium-depleted hepatocytes (cells washed and incubated with 1 mM EGTA), the effect of epinephrine on both enzyme activities was impaired, while the effects of vasopressin and A23187 were completely abolished.	Egtazic Acid	70-74	arginine vasopressin	Rattus norvegicus	164-175
6102386-3	1980	Calcium ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) buffers (pCa = 6.4) reduced basal ODCase activity and blocked the increase in activity by beta-adrenergic agonists, dibutyryl cyclic AMP, or serum.	Egtazic Acid	79-83	ornithine decarboxylase, structural 1	Mus musculus	119-125
6256485-3	1980	The 5"-nucleotidase in the homogenates and in isolated myelin had optimum activity at pH 7.5--9.0, was stimulated by Mg2+ and Mn2+, and was inhibited by Co2+, Zn2+, EDTA, and EGTA.	Egtazic Acid	175-179	5' nucleotidase, ecto	Rattus norvegicus	4-19
6250592-2	1980	(1) Various kinds of cell, such as Ehrlich ascites tumor cells, mouse melanoma cells (B16-CW1 cells) and human epidermoid carcinoma cells (KB cells), could fuse in Ca2+-free medium containing a cheletor, glycoletherdiaminetetraacetic acid, in the same way as in Ca2+-containing medium.	Egtazic Acid	204-238	Polykaryocytosis inducer	Homo sapiens	156-160
6102386-9	1980	The inhibition of ODCase activity by colchicine or EGTA was distinct from that seen with cycloheximide and could not be correlated to their effects on general protein synthesis.	Egtazic Acid	51-55	ornithine decarboxylase, structural 1	Mus musculus	18-24
6102386-10	1980	Colchicine or EGTA each caused identical rates of decline in ODCase activity with a half-time of 20-30 min after an initial lag period of about 60 min.	Egtazic Acid	14-18	ornithine decarboxylase, structural 1	Mus musculus	61-67
7415801-2	1980	Infusion of EGTA resulted in an increase of parathyroid hormone (PTH) and infusion of CaCl2, in a decrease of this hormone.	Egtazic Acid	12-16	parathyroid hormone	Canis lupus familiaris	44-63
7415801-2	1980	Infusion of EGTA resulted in an increase of parathyroid hormone (PTH) and infusion of CaCl2, in a decrease of this hormone.	Egtazic Acid	12-16	parathyroid hormone	Canis lupus familiaris	65-68
490364-8	1979	Adding 5 mM-EGTA to Ca-deprived medium stimulated a greater rate of renin release than that of Ca-deprived medium alone.	Egtazic Acid	12-16	renin	Rattus norvegicus	68-73
115902-4	1979	EGTA (3 mM) inhibited erythropoietin-induced erythroid colony formation.	Egtazic Acid	0-4	erythropoietin	Mus musculus	22-36
115902-7	1979	EGTA substantially inhibited erythropoietin-induced erythroid colony formation even when the marrow cells were exposed to the hormone for up to 2 h before addition of the chelator.	Egtazic Acid	0-4	erythropoietin	Mus musculus	29-43
158984-7	1979	Thus the EGTA-insensitive rise in tension during metabolic depletion is due to activation of Mg-ATPase and loss of Ca sensitivity at 37 degrees C, a temperature at which mammalian smooth muscles normally function.	Egtazic Acid	9-13	dynein axonemal heavy chain 8	Homo sapiens	96-102
464093-2	1979	Incubation in Ca2+-free Ringer (0.1 mM EGTA) abolished tone and contractions.	Egtazic Acid	39-43	carbonic anhydrase 2	Homo sapiens	14-17
109470-5	1979	Bovine parathyroid hormone stimulated the 1- and reduced the 24-hydroxylase in 6 h, but this only occurred in cultures either previously treated with 1,25(OH)2D3 and EGTA to lower Ca to 0.8 mM or in cultures grown in the presence of 25-hydroxyvitamin D3 (25(OH)D3).	Egtazic Acid	166-170	parathyroid hormone	Bos taurus	7-26
530525-3	1979	The A II-evoked release of [3H]-DA was prevented when slices were superfused with a calcium-free medium containing EGTA 5 .	Egtazic Acid	115-119	angiotensinogen	Rattus norvegicus	4-8
158984-2	1979	Chicken gizzard actomyosin shows a progressive loss of Ca sensitivity accompanied by activation of EGTA-Mg-ATPase at temperatures near 37 degrees C with decreasing ATP concentrations.	Egtazic Acid	99-103	dynein axonemal heavy chain 8	Homo sapiens	107-113
158984-4	1979	Activation of EGTA-Mg-ATPase at low ATP concentration is not due to a pseudo-ATPase, or due to denautration of the actomyosin at 37 degrees C. Magnesium concentrations above 1 mM are required for observing the enhanced EGTA-Mg-ATPase activity and the Ca sensitivity is very markedly influenced by the magnesium concentrations of medium at low ATP.	Egtazic Acid	14-18	dynein axonemal heavy chain 8	Homo sapiens	22-28
158984-4	1979	Activation of EGTA-Mg-ATPase at low ATP concentration is not due to a pseudo-ATPase, or due to denautration of the actomyosin at 37 degrees C. Magnesium concentrations above 1 mM are required for observing the enhanced EGTA-Mg-ATPase activity and the Ca sensitivity is very markedly influenced by the magnesium concentrations of medium at low ATP.	Egtazic Acid	219-223	dynein axonemal heavy chain 8	Homo sapiens	22-28
479482-7	1979	Activation of both properdin factor B and C3 was only partially inhibited by ethylene glycol tetraacetic acid, demonstrating that activation was occurring through both the classical and alternative pathways.	Egtazic Acid	77-109	complement factor B	Homo sapiens	19-44
638160-16	1978	But phospholipase A1 lost complete activity in presence of 0.5 mM ethyleneglycolbis-(beta-aminoethylether)-N,N"-tetraacetic acid (EGTA) at pH 6.0, whereas phospholipase A2 lost only 50%.	Egtazic Acid	130-134	phospholipase A2 group IB	Rattus norvegicus	155-171
119692-5	1979	The DA releasing effect of TRH was completely blocked by cholinergic blockers (scopolamine, hexamethonium and hemicholinium), Ca2+ chelator(EGTA), Ca2+ antagonist(CoCl2) and Ca2+ influx blocker(D-600) or by the removal of Ca2+ from the medium.	Egtazic Acid	140-144	thyrotropin releasing hormone	Rattus norvegicus	27-30
109057-6	1979	Alternative complement pathway consumption was demonstrated in only one of the septic burned patients, as evidenced by decreased factor B and C3b INA levels and decreased C3 and C5 conversion in sera treated with 10 mM ethylene glycol tetraacetic acid and 10 mM MgCl(2) (MgEGTA) and in untreated sera.	Egtazic Acid	219-251	complement C3	Homo sapiens	142-145
232524-3	1979	Trypsin or ethyleneglycoltetraacetic acid (EGTA) alone increases insulin binding twofold to threefold, but fails to further increase 125I-insulin binding in cells pretreated with dibucaine.	Egtazic Acid	11-41	insulin	Gallus gallus	65-72
232524-3	1979	Trypsin or ethyleneglycoltetraacetic acid (EGTA) alone increases insulin binding twofold to threefold, but fails to further increase 125I-insulin binding in cells pretreated with dibucaine.	Egtazic Acid	43-47	insulin	Gallus gallus	65-72
33047-5	1978	Addition of purified protein MAP2 after chelation of calcium by EGTA, immediately restores microtubule assembly.	Egtazic Acid	64-68	microtubule associated protein 2	Homo sapiens	29-33
204635-4	1978	In the presence of 0.1 mM EDTA or ethylene glycol bis(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA), it is eluted from the column immediately before a cyclic GMP-specific phosphodiesterase, but in the presence of 0.2 mM Ca2+, the elution follows that of the cyclic GMP-specific enzyme.	Egtazic Acid	34-97	5'-nucleotidase, cytosolic II	Homo sapiens	163-166
204635-4	1978	In the presence of 0.1 mM EDTA or ethylene glycol bis(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA), it is eluted from the column immediately before a cyclic GMP-specific phosphodiesterase, but in the presence of 0.2 mM Ca2+, the elution follows that of the cyclic GMP-specific enzyme.	Egtazic Acid	34-97	5'-nucleotidase, cytosolic II	Homo sapiens	270-273
457762-3	1979	Subsequent dialysis against EGTA followed by sieve chromatography results in purification of the 10,000-dalton ligatin monomer.	Egtazic Acid	28-32	eukaryotic translation initiation factor 2D	Gallus gallus	111-118
209016-12	1978	Ca-activated hydrolysis of ATP catalyzed by gizzard myosin B proceeded at a reduced rate after removal of Ca2+ (by adding EGTA), whereas that catalyzed by a combination of actin, gizzard myosin, and gizzard NTM proceeded at the same rate even after removal of Ca2+.	Egtazic Acid	122-126	myosin, heavy chain 15	Gallus gallus	52-58
233767-3	1978	Addition of 5 mM Ca2+ after shortening caused by 4 mM EGTA results in flagellar regeneration.	Egtazic Acid	54-58	carbonic anhydrase 2	Homo sapiens	17-20
233767-6	1978	A specific requirement for Ca2+ in flagellar regeneration could be demonstrated, however, because as little as 50 microM EGTA in the presence of 500 microM Mg2+ delayed regeneration and prevented full regeneration.	Egtazic Acid	121-125	carbonic anhydrase 2	Homo sapiens	27-30
204635-4	1978	In the presence of 0.1 mM EDTA or ethylene glycol bis(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA), it is eluted from the column immediately before a cyclic GMP-specific phosphodiesterase, but in the presence of 0.2 mM Ca2+, the elution follows that of the cyclic GMP-specific enzyme.	Egtazic Acid	99-103	5'-nucleotidase, cytosolic II	Homo sapiens	163-166
413096-4	1977	On the other hand, the vertical amplitude of the s infinity-curve on the current axis, proportional to gK2, was enlarged during CaCl2 injections and strongly diminished by K-EGTA injections.	Egtazic Acid	174-178	glycerol kinase 2	Ovis aries	103-106
204635-4	1978	In the presence of 0.1 mM EDTA or ethylene glycol bis(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA), it is eluted from the column immediately before a cyclic GMP-specific phosphodiesterase, but in the presence of 0.2 mM Ca2+, the elution follows that of the cyclic GMP-specific enzyme.	Egtazic Acid	99-103	5'-nucleotidase, cytosolic II	Homo sapiens	270-273
25957-4	1978	The concentration of free Ca2+ in the solutions was buffered with ethylene glycol-bis (beta-aminoethylether N,N"-tetraacetic acid (EGTA).	Egtazic Acid	66-129	carbonic anhydrase 2	Rattus norvegicus	26-29
25957-4	1978	The concentration of free Ca2+ in the solutions was buffered with ethylene glycol-bis (beta-aminoethylether N,N"-tetraacetic acid (EGTA).	Egtazic Acid	131-135	carbonic anhydrase 2	Rattus norvegicus	26-29
618908-5	1978	Specific binding reached saturation at congruent with5 ng TC II/ml (0.13 nM) and could be inhibited by ethylene glycol-bis (beta-aminoethyl ether) N,N,N",N"- tetraacetic acid.	Egtazic Acid	103-174	transcobalamin 2	Homo sapiens	58-63
146518-7	1978	From the effects of ethyleneglycol-bis-(beta-aminoethylether)-N,N"-tetraacetic acid (EGTA), CaCl2, chlorpromazine and ruthenium red it is concluded that the enzyme activity does not represent a separate entity but is part of the (Ca2+ + Mg2+)-ATPase system of the erythrocyte membrane.	Egtazic Acid	20-83	plasma membrane calcium-transporting ATPase 1	Oryctolagus cuniculus	230-249
146518-7	1978	From the effects of ethyleneglycol-bis-(beta-aminoethylether)-N,N"-tetraacetic acid (EGTA), CaCl2, chlorpromazine and ruthenium red it is concluded that the enzyme activity does not represent a separate entity but is part of the (Ca2+ + Mg2+)-ATPase system of the erythrocyte membrane.	Egtazic Acid	85-89	plasma membrane calcium-transporting ATPase 1	Oryctolagus cuniculus	230-249
410816-9	1977	Magnesium-ethylene glycol bis[beta-aminoethyl ether]N,N"-tetraacetic acid (Mg [2.5 mM]-EGTA [5.0 mM]) blocked the C5a-evoked potential changes, whereas colchine (10(- 6)M) and cytochalasin B (3.0 mug/ml did not.	Egtazic Acid	87-91	complement C5a receptor 1	Homo sapiens	114-117
181380-5	1976	Stimulation of calcium outflux or cellular cyclic GMP by CCK-OP or carbamylcholine did not require extracellular calcium since stimulation occurred in a calcium-free, ethylene glycol bis(beta, beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA)-containing solution.	Egtazic Acid	239-243	cholecystokinin	Cavia porcellus	57-60
142767-4	1977	In a superprecipitation test in the presence of EGTA, actomyosin reconstituted from dephosphorylated gizzard myosin did not superprecipitate, whereas actomyosin reconstituted from phosphorylated gizzard myosin showed superprecipitation activity which was inhibited by skeletal NTM and reactivated by Ca.	Egtazic Acid	48-52	myosin, heavy chain 15	Gallus gallus	58-64
402166-0	1977	The effects of EDTA and EGTA on renin secretion.	Egtazic Acid	24-28	renin	Rattus norvegicus	32-37
402166-5	1977	6 EGTA was less effective as a renin releaser than EDTA until magnesium was removed from the perfusate.	Egtazic Acid	2-6	renin	Rattus norvegicus	31-36
328014-10	1977	The release of insulin evoked by theophylline is abolished in calcium-depleted media containing EGTA.	Egtazic Acid	96-100	insulin	Homo sapiens	15-22
402382-4	1977	Addition of ethylene glycol bis (beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA), ethylenediamine tetraacetic acid (EDTA), or La2+ inhibited hCG release from the cells, but did not affect the amount of hCG in the cells.	Egtazic Acid	12-76	chorionic gonadotropin subunit beta 5	Homo sapiens	144-147
402382-6	1977	Inhibition of hCG secretion by EGTA was reversed upon removal of the EGTA from the culture fluid or by addition of equimolar Ca2+ to the fluid.	Egtazic Acid	31-35	chorionic gonadotropin subunit beta 5	Homo sapiens	14-17
402382-6	1977	Inhibition of hCG secretion by EGTA was reversed upon removal of the EGTA from the culture fluid or by addition of equimolar Ca2+ to the fluid.	Egtazic Acid	69-73	chorionic gonadotropin subunit beta 5	Homo sapiens	14-17
836870-3	1977	When calcium is sequestred by EGTA the degradation of TN-C is much faster.	Egtazic Acid	30-34	tenascin C	Homo sapiens	54-58
826360-2	1976	These serum factors were detected by lysis of gluthathione-sensitized human erythrocytes and by C3 and factor B conversion in the presence of EGTA (10 mM) and MgCl2 (0-3 mM), conditions which blocked activation of the classical pathway but permitted activation of the alternative pathway.	Egtazic Acid	142-146	complement C3	Homo sapiens	96-111
772186-8	1976	Platelets degramulated, but not aggregated, by exposure to TH in the presence of ethylene glycol bis(beta--aminoethyl ether)-N, N"-tetraacetic acid and plasmin were isolated by sepharose gel filtration.	Egtazic Acid	81-147	coagulation factor II, thrombin	Homo sapiens	59-61
1191690-3	1975	A fraction of Ca2+ of 50-60 nmol/mg protein, rapidly taken up by sarcoplasmic reticulum, exchanges with Mg2+ and K+ in the medium and is readily released by ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid, but it is not released by X-537A.	Egtazic Acid	157-221	carbonic anhydrase 2	Oryctolagus cuniculus	14-17
1177102-11	1975	With a strong buffering of the free [Ca2+] with 4-0 mM total EGTA, a smaller tonic tension was developed for a given pCa in the presence of a higher free [Mg2+].	Egtazic Acid	61-65	carbonic anhydrase 2	Rattus norvegicus	37-40
809571-6	1975	In the presence of a strong buffering of the free [Ca2+] with 4-0 mM total EGTA, a tonic tension was obtained that increased according to t sigmoid curve when the free ([Ca2+] was increased from 10(-6-75)M to 10(-5-0)M. This curve was not modified by the destruction of the sarcoplasmic reticulum (SR) by the detergent Brij 58.	Egtazic Acid	75-79	carbonic anhydrase 2	Rattus norvegicus	51-54
809571-6	1975	In the presence of a strong buffering of the free [Ca2+] with 4-0 mM total EGTA, a tonic tension was obtained that increased according to t sigmoid curve when the free ([Ca2+] was increased from 10(-6-75)M to 10(-5-0)M. This curve was not modified by the destruction of the sarcoplasmic reticulum (SR) by the detergent Brij 58.	Egtazic Acid	75-79	carbonic anhydrase 2	Rattus norvegicus	170-173
809571-9	1975	In the presence of a slight buffering of the free [Ca2+] with 0-050 mM total EGTA, cyclic contractions were observed that were attributed to cyclic releases and re-sequestrations of Ca2+ by the SR.	Egtazic Acid	77-81	carbonic anhydrase 2	Rattus norvegicus	51-54
1177102-2	1975	In the presence of a slight buffering of the free [Ca2+] with 0.050 mM total EGTA cyclic contractions were induced by a Ca2+-triggered release of Ca2+ on skinned (sarcolemma-free) segments of single cardiac cells from rat ventricle.	Egtazic Acid	77-81	carbonic anhydrase 2	Rattus norvegicus	51-54
4276179-8	1974	In 0.1 mM calcium salts the ATPase activity is approximately 60% of that in 1 mM EGTA.	Egtazic Acid	81-85	dynein axonemal heavy chain 8	Homo sapiens	28-34
1177102-2	1975	In the presence of a slight buffering of the free [Ca2+] with 0.050 mM total EGTA cyclic contractions were induced by a Ca2+-triggered release of Ca2+ on skinned (sarcolemma-free) segments of single cardiac cells from rat ventricle.	Egtazic Acid	77-81	carbonic anhydrase 2	Rattus norvegicus	120-123
1177102-2	1975	In the presence of a slight buffering of the free [Ca2+] with 0.050 mM total EGTA cyclic contractions were induced by a Ca2+-triggered release of Ca2+ on skinned (sarcolemma-free) segments of single cardiac cells from rat ventricle.	Egtazic Acid	77-81	carbonic anhydrase 2	Rattus norvegicus	120-123
24194400-5	1975	Studies utilizing preparations of C5, EDTA, magnesium-EGTA, CS-deficient serum, and serum heated for 20 min at 50 C demonstrate that generation of C5a results from activation of the complement system as well as from direct cleavage of C5.	Egtazic Acid	54-58	complement C5a receptor 1	Homo sapiens	147-150
240133-3	1975	The activation of tyrosine hydroxylase produced by calcium is reversed by addition of the calcium chelator, EGTA, while the activation produced by cAMP addition or by electrical stimulation of the locus coeruleus is unaffected by addition of EGTA to the assay medium.	Egtazic Acid	108-112	tyrosine hydroxylase	Rattus norvegicus	18-38
809571-9	1975	In the presence of a slight buffering of the free [Ca2+] with 0-050 mM total EGTA, cyclic contractions were observed that were attributed to cyclic releases and re-sequestrations of Ca2+ by the SR.	Egtazic Acid	77-81	carbonic anhydrase 2	Rattus norvegicus	182-185
240699-1	1975	This report describes a kinetic analysis of energy-linked Ca2+ transport in rat liver mitochondria, in which a ruthenium red/EGTA [ethanedioxy-bis(ethylamine)-tetraacetic acid] quenching technique has been used to measure rates of 45Ca2+ transport.	Egtazic Acid	125-129	carbonic anhydrase 2	Rattus norvegicus	58-61
33432416-7	2021	Ca and EGTA counteracted the inhibitory effect of Cd on the activity and gene expression of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) isoenzyme and modulated the activities of catalase (CAT) and ascorbate peroxidase (APX).	Egtazic Acid	7-11	L-ascorbate peroxidase, cytosolic	Cicer arietinum	214-217
33946319-6	2021	Experiments with Ca2+ buffering by EGTA or BAPTA suggest close local arrangement of functional CaCCs and TRPC1 channels.	Egtazic Acid	35-39	transient receptor potential cation channel subfamily C member 1	Homo sapiens	105-110
33519429-6	2020	Similarly, STAT1 phosphorylation could also be abolished by extracellular calcium chelating agent EGTA and intracellular calcium chelator BAPTA-AM.	Egtazic Acid	98-102	signal transducer and activator of transcription 1	Homo sapiens	11-16
33432416-7	2021	Ca and EGTA counteracted the inhibitory effect of Cd on the activity and gene expression of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) isoenzyme and modulated the activities of catalase (CAT) and ascorbate peroxidase (APX).	Egtazic Acid	7-11	catalase-4	Cicer arietinum	173-181
33432416-7	2021	Ca and EGTA counteracted the inhibitory effect of Cd on the activity and gene expression of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) isoenzyme and modulated the activities of catalase (CAT) and ascorbate peroxidase (APX).	Egtazic Acid	7-11	catalase-4	Cicer arietinum	183-186
33432416-7	2021	Ca and EGTA counteracted the inhibitory effect of Cd on the activity and gene expression of Cu/Zn-superoxide dismutase (Cu/Zn-SOD) isoenzyme and modulated the activities of catalase (CAT) and ascorbate peroxidase (APX).	Egtazic Acid	7-11	L-ascorbate peroxidase, cytosolic	Cicer arietinum	192-212
18631460-2	1969	Myosin filaments were also present when homogenates were diluted (1 : 9) with solutions containing additional Mg(++) and ATP provided naturally occurring traces of Ca(++) had not been chelated with EGTA.	Egtazic Acid	198-202	myosin, heavy chain 15	Gallus gallus	0-6
33176450-10	2021	Moreover, transfusion of EGTA-treated, cold-stored platelets, but not room temperature-stored platelets, into the mice deficient in glycoprotein Ibalpha significantly shortened tail-bleeding times and diminished blood loss.	Egtazic Acid	25-29	glycoprotein 1b, alpha polypeptide	Mus musculus	132-152
32188708-7	2020	Chelating Ca2+ using EGTA prevented synaptic inhibition by G85R-SOD1, confirming the role of aberrant Ca2+ in mediating G85R-SOD1 toxicity.	Egtazic Acid	21-25	superoxide dismutase 1	Homo sapiens	64-68
33306408-4	2021	Using EGTA enhanced glutathione reductase and glutathione S transferase activities in the liver and kidney.	Egtazic Acid	6-10	glutathione-disulfide reductase	Rattus norvegicus	20-41
33306408-4	2021	Using EGTA enhanced glutathione reductase and glutathione S transferase activities in the liver and kidney.	Egtazic Acid	6-10	hematopoietic prostaglandin D synthase	Rattus norvegicus	46-71
33281629-9	2020	The activation of the MAPK/NF-kappaB signaling was halted by NAC, EGTA, and HC030031.	Egtazic Acid	66-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
32905316-1	2020	Two kinds of tetravalent double-headed sialo-glycosides with short/long spacers between the Neu5Acalpha2,6Galbeta1,4GlcNAc unit and ethylene glycol tetraacetic acid (EGTA) scaffold were found to be capable of binding to virus-like particles of Merkel cell polyomavirus (MCPyV-LP).	Egtazic Acid	132-164	neu5acalpha2,6galbeta1	None	92-114
32188708-7	2020	Chelating Ca2+ using EGTA prevented synaptic inhibition by G85R-SOD1, confirming the role of aberrant Ca2+ in mediating G85R-SOD1 toxicity.	Egtazic Acid	21-25	superoxide dismutase 1	Homo sapiens	125-129
31035643-5	2019	The protease activity is partially inhibited by divalent cation chelators ethylenediaminetetraacetic acid (EDTA) and ethylene-bis(oxyethylenenitrilo)tetraacetic acid (EGTA), and human alpha-2-macroglobulin (A2M), a non-specific protease inhibitor.	Egtazic Acid	167-171	alpha-2-macroglobulin	Homo sapiens	184-205
31973054-12	2020	To account for this improvement, the density functional theory (DFT) was employed to calculate the EGTA-metal ion interaction energy, which was found to be -374.6 and -116.4 kJ/mol for Pb(II) and Cu(II), respectively, considering solvation effects.	Egtazic Acid	99-103	submaxillary gland androgen regulated protein 3B	Homo sapiens	185-202
31822471-13	2019	In contrast to the obvious dependence of membrane beta-catenin on CK stability, the detachment of beta-catenin from the plasma membrane via uncoupling of cadherins by Ca2+ chelator EGTA had no effect on the CK integrity.	Egtazic Acid	181-185	catenin beta 1	Xenopus tropicalis	98-110
31220451-9	2019	In mouse keratinocytes, alpha-MSH increased the production of TXA2, which was inhibited by adenylyl cyclase inhibitor SQ-22536 and Ca2+ chelator EGTA.	Egtazic Acid	145-149	STAM binding protein	Mus musculus	24-33
31075903-7	2019	Interestingly, expression levels of genes encoding Ca2+ transporters (ACA10, plasma membrane PIIB-type Ca2+-ATPase; and CAX3, vacuolar cation/proton exchanger) were upregulated by ethylene glycol tetraacetic acid (EGTA) and abscisic acid (ABA).	Egtazic Acid	180-212	autoinhibited Ca(2+)-ATPase 10	Arabidopsis thaliana	70-75
31075903-7	2019	Interestingly, expression levels of genes encoding Ca2+ transporters (ACA10, plasma membrane PIIB-type Ca2+-ATPase; and CAX3, vacuolar cation/proton exchanger) were upregulated by ethylene glycol tetraacetic acid (EGTA) and abscisic acid (ABA).	Egtazic Acid	180-212	cation exchanger 3	Arabidopsis thaliana	120-124
31075903-7	2019	Interestingly, expression levels of genes encoding Ca2+ transporters (ACA10, plasma membrane PIIB-type Ca2+-ATPase; and CAX3, vacuolar cation/proton exchanger) were upregulated by ethylene glycol tetraacetic acid (EGTA) and abscisic acid (ABA).	Egtazic Acid	214-218	autoinhibited Ca(2+)-ATPase 10	Arabidopsis thaliana	70-75
31075903-7	2019	Interestingly, expression levels of genes encoding Ca2+ transporters (ACA10, plasma membrane PIIB-type Ca2+-ATPase; and CAX3, vacuolar cation/proton exchanger) were upregulated by ethylene glycol tetraacetic acid (EGTA) and abscisic acid (ABA).	Egtazic Acid	214-218	cation exchanger 3	Arabidopsis thaliana	120-124
32110998-5	2020	The voltage-dependent component of ANO1 has outward rectifying and sustained characteristics and is clearly isolated by the inhibitory effect of Cl- reduction and T16Ainh-A01, a selective ANO1 inhibitor, in high EGTA, a Ca2+ chelator.	Egtazic Acid	212-216	anoctamin 1, calcium activated chloride channel	Mus musculus	35-39
31998078-5	2019	In addition, Bic could further increase the number of TH or BrdU-positive cells as well as the expression levels of aforementioned proteins except for TH/BrdU-double positive cells, while EGTA and Nifedipine could attenuate the expression levels of CaM, CaMKIIdelta3 and BDNF.	Egtazic Acid	188-192	MIR155 host gene	Homo sapiens	13-16
31998078-5	2019	In addition, Bic could further increase the number of TH or BrdU-positive cells as well as the expression levels of aforementioned proteins except for TH/BrdU-double positive cells, while EGTA and Nifedipine could attenuate the expression levels of CaM, CaMKIIdelta3 and BDNF.	Egtazic Acid	188-192	brain derived neurotrophic factor	Homo sapiens	271-275
31834925-6	2019	Serum stimulation induced rapid phosphorylation of LC20 at T18 and S19, MYPT1 at T696 and T853, and Par-4 at T163, peaking within 30-120 s. MLCK knockdown or inhibition, or Ca2+ chelation with EGTA, had no effect on serum-induced LC20 phosphorylation.	Egtazic Acid	193-197	myosin light chain kinase	Homo sapiens	140-144
31429706-4	2019	The treatment of seeds with calcium ions (Ca2+) enhanced the NO level in Arabidopsis seedlings under HS conditions, whereas treatment with EGTA (a Ca2+ chelator) reduced it, implicating that CNGC6 stimulates the accumulation of NO depending on an increase in cytosolic Ca2+ ([Ca2+]cyt).	Egtazic Acid	139-143	cyclic nucleotide-gated channel 6	Arabidopsis thaliana	191-196
30698189-0	2019	Methoxy-substituted tetrakisquinoline analogs of EGTA and BAPTA for fluorescence detection of Cd2+ .	Egtazic Acid	49-53	CD2 molecule	Homo sapiens	94-97
30635263-11	2019	Importantly, ethylene glycol tetraacetic acid (EGTA), which sequesters calcium and thus downregulates calmodulin and calcineurin, was a potent suppressor of vps13Delta.	Egtazic Acid	13-45	calmodulin	Saccharomyces cerevisiae S288C	102-112
30689641-7	2019	Mechanistically, we found that RPGRIP1L regulates the endocytosis of desmogleins such that RPGRIP1L-knockdown not only induced spontaneous desmoglein endocytosis, as determined by AK23 labeling and biotinylation assays, but also exacerbated EGTA- or pemphigus vulgaris IgG-induced desmoglein endocytosis.	Egtazic Acid	241-245	RPGRIP1 like	Homo sapiens	31-39
30689641-7	2019	Mechanistically, we found that RPGRIP1L regulates the endocytosis of desmogleins such that RPGRIP1L-knockdown not only induced spontaneous desmoglein endocytosis, as determined by AK23 labeling and biotinylation assays, but also exacerbated EGTA- or pemphigus vulgaris IgG-induced desmoglein endocytosis.	Egtazic Acid	241-245	RPGRIP1 like	Homo sapiens	91-99
30635263-11	2019	Importantly, ethylene glycol tetraacetic acid (EGTA), which sequesters calcium and thus downregulates calmodulin and calcineurin, was a potent suppressor of vps13Delta.	Egtazic Acid	47-51	calmodulin	Saccharomyces cerevisiae S288C	102-112
29574924-7	2018	Finally, we found Ca2+ chelator EGTA or BAPTA-AM significantly diminished the effects of si-TRPC1 and si-TRPC3 on the cell viability, cell cycle, and the protein expression of p-p38, p-JNK, cleaved caspase-3, and Bcl-2 in asthmatic mouse ASMCs.	Egtazic Acid	32-36	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	92-97
30244168-8	2019	Chelating intracellular free Ca2+ ([Ca2+]i) with BAPTA/AM or preventing [Ca2+]i elevation using EGTA or 2-APB profoundly blocked hsBAFF-induced activation of Akt/mTOR, phosphorylation of ULK1 and decrease of LC3-II, as well as increase of cell proliferation/viability.	Egtazic Acid	96-100	AKT serine/threonine kinase 1	Homo sapiens	158-161
30696338-6	2019	In addition, treatments of seedlings with Ca2+ chelator ethylene glycol-bis(2-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA) and Ca2+ channel blocker lanthanum chloride markedly inhibit changes of [Ca2+]cyt in cbl9 mutants, while the inhibition of calcium release by lithium chloride from intracellular pools demonstrated consistent suppression of [Ca2+]cyt in cbl9 mutants and WT plants.	Egtazic Acid	56-121	calcineurin B-like protein 9	Arabidopsis thaliana	214-218
30696338-6	2019	In addition, treatments of seedlings with Ca2+ chelator ethylene glycol-bis(2-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA) and Ca2+ channel blocker lanthanum chloride markedly inhibit changes of [Ca2+]cyt in cbl9 mutants, while the inhibition of calcium release by lithium chloride from intracellular pools demonstrated consistent suppression of [Ca2+]cyt in cbl9 mutants and WT plants.	Egtazic Acid	56-121	calcineurin B-like protein 9	Arabidopsis thaliana	365-369
30010769-11	2018	EDTA, EGTA and chlorpromazine all inhibited both the nuclear import and the nuclear export of VIP1-GFP, bZIP59-GFP and bZIP29-GFP.	Egtazic Acid	6-10	VIRE2-interacting protein 1	Arabidopsis thaliana	94-98
30010769-11	2018	EDTA, EGTA and chlorpromazine all inhibited both the nuclear import and the nuclear export of VIP1-GFP, bZIP59-GFP and bZIP29-GFP.	Egtazic Acid	6-10	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	119-125
30261424-7	2018	Addition of increasing concentrations of extracellular EGTA also gradually depleted the ER of Ca2+, and, as with the SERCA inhibitors, EGTA-induced activation of UPR and cell death required higher EGTA concentrations than those needed to strongly reduce ER Ca2+ levels.	Egtazic Acid	135-139	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	117-122
30261424-7	2018	Addition of increasing concentrations of extracellular EGTA also gradually depleted the ER of Ca2+, and, as with the SERCA inhibitors, EGTA-induced activation of UPR and cell death required higher EGTA concentrations than those needed to strongly reduce ER Ca2+ levels.	Egtazic Acid	135-139	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	117-122
30266318-6	2018	Ca2+ chelators, ethylene glycol tetraacetic acid and a CaMKII inhibitor, K252a, decreased CPT-induced Beclin-1 and Atg7, and downregulated AMPK phosphorylation, which suggested that CPT-induced Ca2+ release leads to the activation of autophagy through CaMKII-mediated AMPK phosphorylation.	Egtazic Acid	16-48	beclin 1	Homo sapiens	102-110
30266318-6	2018	Ca2+ chelators, ethylene glycol tetraacetic acid and a CaMKII inhibitor, K252a, decreased CPT-induced Beclin-1 and Atg7, and downregulated AMPK phosphorylation, which suggested that CPT-induced Ca2+ release leads to the activation of autophagy through CaMKII-mediated AMPK phosphorylation.	Egtazic Acid	16-48	autophagy related 7	Homo sapiens	115-119
30266318-6	2018	Ca2+ chelators, ethylene glycol tetraacetic acid and a CaMKII inhibitor, K252a, decreased CPT-induced Beclin-1 and Atg7, and downregulated AMPK phosphorylation, which suggested that CPT-induced Ca2+ release leads to the activation of autophagy through CaMKII-mediated AMPK phosphorylation.	Egtazic Acid	16-48	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	139-143
30233623-8	2018	Moreover, EGTA, BAPTA/AM, LaCl3, nifedipine, W-7, and TFP prevented the SNAP-induced upregulation of gene expression of CaM, CBL1, and CBL3, which is associated with calcium signaling pathway.	Egtazic Acid	10-14	calmodulin 1	Homo sapiens	120-123
30233623-8	2018	Moreover, EGTA, BAPTA/AM, LaCl3, nifedipine, W-7, and TFP prevented the SNAP-induced upregulation of gene expression of CaM, CBL1, and CBL3, which is associated with calcium signaling pathway.	Egtazic Acid	10-14	Cbl proto-oncogene C	Homo sapiens	135-139
30426809-5	2019	PCN treatment increased [Ca2+]i in NK92 cells more than twofold after 2 h stimulation, whereas the Ca2+-chelating agent ethylene glycol tetra-acetic acid (EGTA) inhibited apoptosis.	Egtazic Acid	155-159	carbonic anhydrase 2	Homo sapiens	99-102
30622531-12	2018	In adhesion assays using E-cadherin-positive HT-29 cells, DC binding was significantly improved by addition of Mn2+ and decreased in the presence of EGTA, consistent with the dependence of integrin-based interactions on divalent cations.	Egtazic Acid	149-153	cadherin 1	Homo sapiens	25-35
30322800-5	2018	EGTA, a Ca2+-chelating agent, also protected neurons from ouabain-induced injury.	Egtazic Acid	0-4	carbonic anhydrase 2	Rattus norvegicus	8-11
29558694-7	2018	Contraction-dependent calcium transients and activation of 5"-AMP activating protein kinase (AMPK) appears to be involved in this decrease, as the chelating Ca2+ by EGTA blocked contraction-dependent CCL5 reduction, whereas the pharmacological activation of AMPK significantly reduced it.	Egtazic Acid	165-169	chemokine (C-C motif) ligand 5	Mus musculus	200-204
29574924-7	2018	Finally, we found Ca2+ chelator EGTA or BAPTA-AM significantly diminished the effects of si-TRPC1 and si-TRPC3 on the cell viability, cell cycle, and the protein expression of p-p38, p-JNK, cleaved caspase-3, and Bcl-2 in asthmatic mouse ASMCs.	Egtazic Acid	32-36	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	105-110
29574924-7	2018	Finally, we found Ca2+ chelator EGTA or BAPTA-AM significantly diminished the effects of si-TRPC1 and si-TRPC3 on the cell viability, cell cycle, and the protein expression of p-p38, p-JNK, cleaved caspase-3, and Bcl-2 in asthmatic mouse ASMCs.	Egtazic Acid	32-36	B cell leukemia/lymphoma 2	Mus musculus	213-218
29348419-6	2018	Finally, we provide genetic evidence that Dysbindin levels regulate the access to EGTA-sensitive vesicles.	Egtazic Acid	82-86	Dysbindin	Drosophila melanogaster	42-51
29488255-6	2018	Importantly, the developed nanoprobe could successfully be applied for the detection of [Ca2+ ]i and pHi change in adenosine triphosphate (ATP) and ethylene glycol tetraacetic acid (EGTA) stimulation in living cells.	Egtazic Acid	148-180	glucose-6-phosphate isomerase	Homo sapiens	101-104
29488255-6	2018	Importantly, the developed nanoprobe could successfully be applied for the detection of [Ca2+ ]i and pHi change in adenosine triphosphate (ATP) and ethylene glycol tetraacetic acid (EGTA) stimulation in living cells.	Egtazic Acid	182-186	glucose-6-phosphate isomerase	Homo sapiens	101-104
29578584-3	2018	With the surface forces apparatus, we directly measure the binding energy of membrane-anchored Syt1 to an anionic membrane and find that Syt1 binds with ~6 kB T in EGTA, ~10 kB T in Mg2+ and ~18 kB T in Ca2+ .	Egtazic Acid	164-168	synaptotagmin 1	Homo sapiens	95-99
29578584-3	2018	With the surface forces apparatus, we directly measure the binding energy of membrane-anchored Syt1 to an anionic membrane and find that Syt1 binds with ~6 kB T in EGTA, ~10 kB T in Mg2+ and ~18 kB T in Ca2+ .	Egtazic Acid	164-168	synaptotagmin 1	Homo sapiens	137-141
28092099-10	2017	TFP and Ca2+ chelator, EGTA, impeded TRA-8-activated caspase-dependent apoptotic signaling, and TFP decreased TRA-8-induced cell cytotoxicity.	Egtazic Acid	23-27	T cell receptor alpha locus	Homo sapiens	37-40
29535810-10	2018	We also found that silibinin/TRAIL-induced apoptosis was accompanied with intracellular influx of Ca2+, which was stimulated by ER stress and the Ca2+ chelator, ethylene glycol tetraacetic acid (EGTA).	Egtazic Acid	161-193	TNF superfamily member 10	Homo sapiens	29-34
29535810-10	2018	We also found that silibinin/TRAIL-induced apoptosis was accompanied with intracellular influx of Ca2+, which was stimulated by ER stress and the Ca2+ chelator, ethylene glycol tetraacetic acid (EGTA).	Egtazic Acid	195-199	TNF superfamily member 10	Homo sapiens	29-34
28919907-7	2017	DR5-GFP and PIN2 were asymmetrically distributed in ATP-stimulated root tips, this effect was strongly suppressed by EGTA and diminished in Galpha null mutants.	Egtazic Acid	117-121	Auxin efflux carrier family protein	Arabidopsis thaliana	12-16
29170125-6	2018	RAW 264.7 cells internalized the SLP-8348 in a process that was mediated by carbohydrate-receptor interactions since it was inhibited by glucose, mannose or EGTA, a Ca+2 chelating agent.	Egtazic Acid	157-161	superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1	Mus musculus	33-36
29214024-9	2017	Measurements of released insulin in response to ultrasound stimulation showed complete inhibition of insulin secretion by chelating extracellular Ca2+ with 10 mM EGTA (p &lt; 0.01).	Egtazic Acid	162-166	insulin	Homo sapiens	25-32
29214024-9	2017	Measurements of released insulin in response to ultrasound stimulation showed complete inhibition of insulin secretion by chelating extracellular Ca2+ with 10 mM EGTA (p &lt; 0.01).	Egtazic Acid	162-166	insulin	Homo sapiens	101-108
28102910-7	2017	The salt-hypersensitive phenotype of AtPLC4 OE seedlings was partially rescued by EGTA.	Egtazic Acid	82-86	phosphatidylinositol-speciwc phospholipase C4	Arabidopsis thaliana	37-43
28555839-12	2017	It was abolished by EGTA, which preferentially blocked endocytosis of retrievable membrane pre-existing at the surface, and was impaired by oxidation of cholesterol and inhibition of neutral sphingomyelinase.	Egtazic Acid	20-24	sphingomyelin phosphodiesterase 2	Rattus norvegicus	183-207
28608248-13	2017	There was a significant increase in p-CaMKII and BDNF expression in the hippocampus when resveratrol were combined with Mk 801, nimodipine, ryanodine and EGTA.	Egtazic Acid	154-158	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	38-44
28608248-13	2017	There was a significant increase in p-CaMKII and BDNF expression in the hippocampus when resveratrol were combined with Mk 801, nimodipine, ryanodine and EGTA.	Egtazic Acid	154-158	brain derived neurotrophic factor	Mus musculus	49-53
28360106-11	2017	Quantitative assessment of TRPV1-lineage afferents in the epidermis of the hind paws of the reporter mice showed that EGTA and MDL28170 diminished capsaicin-induced ablation.	Egtazic Acid	118-122	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
28536368-5	2017	MEK-ERK signaling activity in RPE cells was strengthened by retinectomy, and nuclear translocation of beta-catenin in RPE cells was induced by attenuation of cell-cell contact, which was promoted by incision of the RPE or its treatment with ethylene glycol tetraacetic acid (EGTA).	Egtazic Acid	241-273	catenin beta 1	Homo sapiens	102-114
28536368-5	2017	MEK-ERK signaling activity in RPE cells was strengthened by retinectomy, and nuclear translocation of beta-catenin in RPE cells was induced by attenuation of cell-cell contact, which was promoted by incision of the RPE or its treatment with ethylene glycol tetraacetic acid (EGTA).	Egtazic Acid	275-279	catenin beta 1	Homo sapiens	102-114
28283478-5	2017	Furthermore, annexin A2 was detected in the conditioned media and an EGTA membrane wash of human lung fibroblast (LF) cultures.	Egtazic Acid	69-73	annexin A2	Homo sapiens	13-23
28193694-7	2017	Conversely, our results suggest that Cav1.3 long isoforms, which carry ~75% of the total IHC Ca2+ current with slow inactivation and confer high sensitivity to nifedipine and to internal EGTA, are essentially involved in recruiting SRP vesicles.	Egtazic Acid	187-191	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	37-43
28496415-9	2017	The intracellular Ca2+ responses to both CSE types were also totally prevented by NAC, AMTB (a TRPM8 antagonist), or EGTA (an extracellular Ca2+ chelator).	Egtazic Acid	117-121	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	41-44
28496415-10	2017	The activation of the MAPK/NF-kappaB signaling and induction of IL-8 to both CSE types were suppressed to similar levels by NAC, AMTB, or EGTA.	Egtazic Acid	138-142	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
28496415-10	2017	The activation of the MAPK/NF-kappaB signaling and induction of IL-8 to both CSE types were suppressed to similar levels by NAC, AMTB, or EGTA.	Egtazic Acid	138-142	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	77-80
26929012-5	2016	Using paired recordings in acute retina slices, we demonstrate that deletion of RIBEYE severely impaired fast and sustained neurotransmitter release at bipolar neuron/AII amacrine cell synapses and rendered spontaneous miniature release sensitive to the slow Ca(2+)-buffer EGTA, suggesting that synaptic ribbons mediate nano-domain coupling of Ca(2+) channels to synaptic vesicle exocytosis.	Egtazic Acid	273-277	C-terminal binding protein 2	Mus musculus	80-86
28030799-12	2017	There was a significant decrease in p-CaMKII and an increase in BDNF expression in the spinal cord when combined with MK 801, nimodipine, ryanodine and EGTA.	Egtazic Acid	152-156	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	38-44
28030799-12	2017	There was a significant decrease in p-CaMKII and an increase in BDNF expression in the spinal cord when combined with MK 801, nimodipine, ryanodine and EGTA.	Egtazic Acid	152-156	brain derived neurotrophic factor	Mus musculus	64-68
26277896-3	2017	We show that different doses of TLR agonists can trigger different levels of cytokine production, which can be potentiated by extracellular calcium but are impaired by the chelating reagent ethylene glycol tetraacetic acid (EGTA) or by knockdown of stromal interaction molecule 1 (STIM1).	Egtazic Acid	190-222	stromal interaction molecule 1	Homo sapiens	281-286
26277896-3	2017	We show that different doses of TLR agonists can trigger different levels of cytokine production, which can be potentiated by extracellular calcium but are impaired by the chelating reagent ethylene glycol tetraacetic acid (EGTA) or by knockdown of stromal interaction molecule 1 (STIM1).	Egtazic Acid	224-228	stromal interaction molecule 1	Homo sapiens	249-279
26277896-3	2017	We show that different doses of TLR agonists can trigger different levels of cytokine production, which can be potentiated by extracellular calcium but are impaired by the chelating reagent ethylene glycol tetraacetic acid (EGTA) or by knockdown of stromal interaction molecule 1 (STIM1).	Egtazic Acid	224-228	stromal interaction molecule 1	Homo sapiens	281-286
26277896-4	2017	Upon TLR engagement, GTP-bound Ras levels are increased and GTP-bound Rap1 is decreased, which can be reversed by EGTA-mediated removal of extracellular calcium.	Egtazic Acid	114-118	RAP1A, member of RAS oncogene family	Homo sapiens	70-74
26277896-5	2017	Furthermore, we demonstrate that Rap1 knockdown rescues the inhibitory effects of EGTA on the TLR-triggered innate response.	Egtazic Acid	82-86	RAP1A, member of RAS oncogene family	Homo sapiens	33-37
28002844-6	2016	ROCK inhibitor and caspase inhibitor effects on apoptosis were also evaluated in MCECs treated with ethylene glycol tetraacetic acid (EGTA) to induce MLC phosphorylation.	Egtazic Acid	100-132	modulator of VRAC current 1	Homo sapiens	150-153
28002844-6	2016	ROCK inhibitor and caspase inhibitor effects on apoptosis were also evaluated in MCECs treated with ethylene glycol tetraacetic acid (EGTA) to induce MLC phosphorylation.	Egtazic Acid	134-138	modulator of VRAC current 1	Homo sapiens	150-153
28002844-9	2016	EGTA-mediated phosphorylation of MLC was sufficient to induce the loss of cell contact with the substrate and subsequent apoptosis.	Egtazic Acid	0-4	modulator of VRAC current 1	Homo sapiens	33-36
27442785-6	2016	In addition, EGTA treatment reduced the DA-9801-induced phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2), the major mediators of neurite outgrowth.	Egtazic Acid	13-17	mitogen activated protein kinase 3	Rattus norvegicus	75-115
27442785-6	2016	In addition, EGTA treatment reduced the DA-9801-induced phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2), the major mediators of neurite outgrowth.	Egtazic Acid	13-17	mitogen activated protein kinase 3	Rattus norvegicus	117-123
26492131-7	2015	Finally, the addition of the calcium chelator EGTA prevented heat-induced AOX1 expression.	Egtazic Acid	46-50	uncharacterized protein	Chlamydomonas reinhardtii	74-78
26998625-8	2016	Attenuating intracellular calcium concentration with EGTA, heparin or procaine decreased POX-induced upregulation of calpain 1, calpain 2, caspase-12 and caspase-3, and reduced POX-induced cyt c release.	Egtazic Acid	53-57	calpain 1	Mus musculus	117-126
26998625-8	2016	Attenuating intracellular calcium concentration with EGTA, heparin or procaine decreased POX-induced upregulation of calpain 1, calpain 2, caspase-12 and caspase-3, and reduced POX-induced cyt c release.	Egtazic Acid	53-57	calpain 2	Mus musculus	128-137
26998625-8	2016	Attenuating intracellular calcium concentration with EGTA, heparin or procaine decreased POX-induced upregulation of calpain 1, calpain 2, caspase-12 and caspase-3, and reduced POX-induced cyt c release.	Egtazic Acid	53-57	caspase 12	Mus musculus	139-149
26998625-8	2016	Attenuating intracellular calcium concentration with EGTA, heparin or procaine decreased POX-induced upregulation of calpain 1, calpain 2, caspase-12 and caspase-3, and reduced POX-induced cyt c release.	Egtazic Acid	53-57	caspase 3	Mus musculus	154-163
26998625-9	2016	After pretreatment with EGTA or procaine, POX significantly promoted expression of Grp 78.	Egtazic Acid	24-28	heat shock protein 5	Mus musculus	83-89
26763850-3	2016	We found that Ang II acutely increased intracellular Ca2+ content, an effect that was inhibited by the extracellular Ca2+ chelator ethylene glycol tetraacetic acid (EGTA) and the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release inhibitor 2-aminoethoxydiphenyl borate (2-APB).	Egtazic Acid	131-163	angiotensinogen	Rattus norvegicus	14-20
26763850-3	2016	We found that Ang II acutely increased intracellular Ca2+ content, an effect that was inhibited by the extracellular Ca2+ chelator ethylene glycol tetraacetic acid (EGTA) and the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release inhibitor 2-aminoethoxydiphenyl borate (2-APB).	Egtazic Acid	131-163	carbonic anhydrase 2	Rattus norvegicus	53-56
26763850-3	2016	We found that Ang II acutely increased intracellular Ca2+ content, an effect that was inhibited by the extracellular Ca2+ chelator ethylene glycol tetraacetic acid (EGTA) and the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release inhibitor 2-aminoethoxydiphenyl borate (2-APB).	Egtazic Acid	131-163	carbonic anhydrase 2	Rattus norvegicus	117-120
26763850-3	2016	We found that Ang II acutely increased intracellular Ca2+ content, an effect that was inhibited by the extracellular Ca2+ chelator ethylene glycol tetraacetic acid (EGTA) and the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release inhibitor 2-aminoethoxydiphenyl borate (2-APB).	Egtazic Acid	131-163	carbonic anhydrase 2	Rattus norvegicus	117-120
26763850-3	2016	We found that Ang II acutely increased intracellular Ca2+ content, an effect that was inhibited by the extracellular Ca2+ chelator ethylene glycol tetraacetic acid (EGTA) and the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release inhibitor 2-aminoethoxydiphenyl borate (2-APB).	Egtazic Acid	165-169	angiotensinogen	Rattus norvegicus	14-20
26763850-3	2016	We found that Ang II acutely increased intracellular Ca2+ content, an effect that was inhibited by the extracellular Ca2+ chelator ethylene glycol tetraacetic acid (EGTA) and the inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release inhibitor 2-aminoethoxydiphenyl borate (2-APB).	Egtazic Acid	165-169	carbonic anhydrase 2	Rattus norvegicus	53-56
26763850-4	2016	Further study showed that EGTA almost completely blocked Ang II-induced lysosome fusion, the translocation of acid sphingomyelinase (ASMase) to LR clusters, ASMase activation and NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activation.	Egtazic Acid	26-30	angiotensinogen	Rattus norvegicus	57-63
26742036-6	2016	Besides, pretreatment with the Ca(2+) chelator (EGTA) and CaM antagonists (CPZ and TFP) suppressed NPPB-elevated cytosolic Ca(2+) fluorescence intensity and CaM concentration in tea roots, respectively.	Egtazic Acid	48-52	natriuretic peptide B	Homo sapiens	99-103
26742036-7	2016	Interestingly, NPPB-inhibited F accumulation was found to be significantly alleviated in tea plants pretreated with either Ca(2+) chelator (EGTA) or CaM antagonists (CPZ and TFP).	Egtazic Acid	140-144	natriuretic peptide B	Homo sapiens	15-19
25597298-8	2015	The EGTA effect in nominal zero Ca(2+) media was mimicked by two calmodulin antagonists, W7 and calmidazolium, and by the calcineurin inhibitor cyclosporine A.	Egtazic Acid	4-8	calmodulin 2	Mus musculus	65-75
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	103-107	complement C3	Homo sapiens	18-21
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	103-107	complement C5	Homo sapiens	26-29
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	127-131	complement C3	Homo sapiens	18-21
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	127-131	complement C5	Homo sapiens	26-29
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	127-131	complement C3	Homo sapiens	18-21
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	127-131	complement C5	Homo sapiens	26-29
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	127-131	complement C3	Homo sapiens	18-21
25963026-9	2015	The deposition of C3b and C5b-9 on NETs incubated with heat-inactivated normal human serum (Hi-NHS) or EGTA-treated Hi-NHS (Mg-EGTA-Hi-NHS) were significantly less than that on NETs incubated with NHS or EGTA-treated NHS (Mg-EGTA-NHS).	Egtazic Acid	127-131	complement C5	Homo sapiens	26-29
25398213-2	2015	Here, we characterised a novel calreticulin (CRT2) gene in the dinoflagellate Prorocentrum minimum, which codes for a calcium binding protein and examined its expression pattern following the addition of calcium and ethylene glycol-bis(2-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	216-281	calreticulin	Homo sapiens	31-43
26005911-9	2015	In HCT116 and HT-29 cells, the alphaLA-induced [Ca(2+)]i increase was partially inhibited by pretreatment with EGTA, phospholipase C inhibitor edelfosine, cADPR inhibitors 8-bro-cADPR or DAB, and abolished by pretreatment with Ca(2+)ATPase inhibitor thapsigargin, but was not affected by Gi/o protein inhibitor PTX or IP3R inhibitor 2-APB.	Egtazic Acid	111-115	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	318-322
25640842-1	2015	We have shown that Mg/EGTA (5 mM Mg(2+) and 1.5 mM EGTA) could effectively promote the adhesion of integrin alphaLbeta2 to its ligand ICAM-1 but could not promote that of the alphaMbeta2 to denatured BSA.	Egtazic Acid	22-26	intercellular adhesion molecule 1	Bos taurus	134-140
25640842-1	2015	We have shown that Mg/EGTA (5 mM Mg(2+) and 1.5 mM EGTA) could effectively promote the adhesion of integrin alphaLbeta2 to its ligand ICAM-1 but could not promote that of the alphaMbeta2 to denatured BSA.	Egtazic Acid	51-55	intercellular adhesion molecule 1	Bos taurus	134-140
26615639-10	2015	Obtained dependence of the number of CD4+CD69+ T cells from EGTA can be represented as a nonlinear curve with two distinct peaks.	Egtazic Acid	60-64	CD4 molecule	Homo sapiens	37-40
26615639-10	2015	Obtained dependence of the number of CD4+CD69+ T cells from EGTA can be represented as a nonlinear curve with two distinct peaks.	Egtazic Acid	60-64	CD69 molecule	Homo sapiens	41-45
26615639-16	2015	All dependences shape have similar curve describing the influence of [EGTA] values on activated CD4+CD69+ T cells.	Egtazic Acid	70-74	CD4 molecule	Homo sapiens	96-99
26615639-16	2015	All dependences shape have similar curve describing the influence of [EGTA] values on activated CD4+CD69+ T cells.	Egtazic Acid	70-74	CD69 molecule	Homo sapiens	100-104
25797048-5	2015	DiC8-PIP3 induced the phosphorylation of Akt-Ser(473) which was reduced by the Akt inhibitor IV, wortmannin and EGTA (suggesting a dependence on Ca(2+) entry).	Egtazic Acid	112-116	AKT serine/threonine kinase 1	Homo sapiens	41-44
25775468-8	2015	Conversely, upon incubation in Ca2+-free medium containing EGTA, the labeling intensity of Shank at the PSD decreased to ~70% of controls and the median distance of label from postsynaptic membrane decreased by 9 nm, indicating a preferential loss of Shank molecules in more distal parts of the PSD complex.	Egtazic Acid	59-63	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	91-96
25775468-8	2015	Conversely, upon incubation in Ca2+-free medium containing EGTA, the labeling intensity of Shank at the PSD decreased to ~70% of controls and the median distance of label from postsynaptic membrane decreased by 9 nm, indicating a preferential loss of Shank molecules in more distal parts of the PSD complex.	Egtazic Acid	59-63	SH3 and multiple ankyrin repeat domains 2	Homo sapiens	251-256
25398213-2	2015	Here, we characterised a novel calreticulin (CRT2) gene in the dinoflagellate Prorocentrum minimum, which codes for a calcium binding protein and examined its expression pattern following the addition of calcium and ethylene glycol-bis(2-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	283-287	calreticulin	Homo sapiens	31-43
25150084-8	2015	RESULTS: The Ca(2+) ionophore A23187 suppressed cytokine-stimulated NO production, whereas Ethylene glycol tetraacetic acid and nifedipine increased NO production, iNOS messenger RNA, and iNOS protein expression.	Egtazic Acid	91-123	nitric oxide synthase 2	Rattus norvegicus	164-168
25692602-0	2015	A novel explanation for observed CaMKII dynamics in dendritic spines with added EGTA or BAPTA.	Egtazic Acid	80-84	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	33-39
25692602-2	2015	Our model can also account for the greater-than-control CaMKII activation observed with added EGTA during depolarization.	Egtazic Acid	94-98	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	56-62
25692602-4	2015	After calibration against CaMKII activation data in the absence of chelators, CaMKII activation dynamics due to synaptic input via n-methyl-d-aspartate receptors are qualitatively accounted for in the presence of the chelators EGTA and BAPTA without additional adjustments to the model.	Egtazic Acid	227-231	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	78-84
25692602-5	2015	To account for CaMKII activation dynamics during spine depolarization with added EGTA or BAPTA, the model invokes the modulation of CaV2.3 (R-type) voltage-dependent calcium channel (VDCC) currents observed in the presence of EGTA or BAPTA.	Egtazic Acid	81-85	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	15-21
25692602-5	2015	To account for CaMKII activation dynamics during spine depolarization with added EGTA or BAPTA, the model invokes the modulation of CaV2.3 (R-type) voltage-dependent calcium channel (VDCC) currents observed in the presence of EGTA or BAPTA.	Egtazic Acid	81-85	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	132-138
25692602-5	2015	To account for CaMKII activation dynamics during spine depolarization with added EGTA or BAPTA, the model invokes the modulation of CaV2.3 (R-type) voltage-dependent calcium channel (VDCC) currents observed in the presence of EGTA or BAPTA.	Egtazic Acid	226-230	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	15-21
25692602-5	2015	To account for CaMKII activation dynamics during spine depolarization with added EGTA or BAPTA, the model invokes the modulation of CaV2.3 (R-type) voltage-dependent calcium channel (VDCC) currents observed in the presence of EGTA or BAPTA.	Egtazic Acid	226-230	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	132-138
25692602-6	2015	To our knowledge, this is a novel explanation for the increased CaMKII activation seen in dendritic spines with added EGTA, and suggests that differential modulation of VDCCs by EGTA and BAPTA offers an alternative or complementary explanation for other experimental results in which addition of EGTA or BAPTA produces different effects.	Egtazic Acid	118-122	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	64-70
25597800-1	2015	In this paper, a kind of gold nanoparticle (GNP)-based colorimetric assay has been developed for studying the reversible interaction of beta-amyloid peptide (Abeta) with Cu(2+) and Zn(2+), and quantitatively analyzing four inhibitors (i.e., EDTA, EGTA, histidine and clioquinol) of Cu(2+)/Zn(2+) induced Abeta assembly.	Egtazic Acid	247-251	amyloid beta precursor protein	Homo sapiens	136-156
25150084-8	2015	RESULTS: The Ca(2+) ionophore A23187 suppressed cytokine-stimulated NO production, whereas Ethylene glycol tetraacetic acid and nifedipine increased NO production, iNOS messenger RNA, and iNOS protein expression.	Egtazic Acid	91-123	nitric oxide synthase 2	Rattus norvegicus	188-192
25395303-7	2015	Proinflammatory agents (TNF-alpha, LPS), phosphatase inhibitor (okadaic acid), and G-protein activator (MST) modestly increased (fMLF)EC50, 2- to 4-fold, whereas PTX, Ca(2+) chelators (EGTA/BAPTA), H2O2, GM-CSF, ENA-78, IL-1RA, and LXA4 had no effect.	Egtazic Acid	185-189	tumor necrosis factor	Homo sapiens	24-33
24969778-6	2014	PECAM-1-mediated internalization of GPIbalpha was reduced in the presence of both EGTA and cytochalasin D or latrunculin, but not either individually, and was reduced in mice in which tyrosines 747 and 759 of the cytoplasmic tail of beta3 integrin were mutated to phenylalanine.	Egtazic Acid	82-86	platelet/endothelial cell adhesion molecule 1	Mus musculus	0-7
25323578-5	2014	In addition, VIIa-and PAR2-AP-induced ERK1/2 activation was inhibited by thapsigargin (TG)-induced depletion of intracellular Ca2+ stores and EGTA-mediated removal of extracellular Ca2+.	Egtazic Acid	142-146	F2R like trypsin receptor 1	Homo sapiens	22-26
25323578-5	2014	In addition, VIIa-and PAR2-AP-induced ERK1/2 activation was inhibited by thapsigargin (TG)-induced depletion of intracellular Ca2+ stores and EGTA-mediated removal of extracellular Ca2+.	Egtazic Acid	142-146	mitogen-activated protein kinase 3	Homo sapiens	38-44
25323578-6	2014	It was also identified that VIIa and PAR2-AP-induced proliferation and migration of SW620 cells was modulated by EGTA and TG.	Egtazic Acid	113-117	F2R like trypsin receptor 1	Homo sapiens	37-41
25355221-7	2014	However, a high concentration of EGTA led to a reduction in EPSCs that was significantly stronger in Munc13-3(-/-).	Egtazic Acid	33-37	unc-13 homolog C	Mus musculus	101-109
25361927-7	2014	BAPTA-AM and EGTA partially reduced the increases in the concentrations of MUC5AC and ATP in supernatant with mechanical ventilation.	Egtazic Acid	13-17	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	75-81
24969778-6	2014	PECAM-1-mediated internalization of GPIbalpha was reduced in the presence of both EGTA and cytochalasin D or latrunculin, but not either individually, and was reduced in mice in which tyrosines 747 and 759 of the cytoplasmic tail of beta3 integrin were mutated to phenylalanine.	Egtazic Acid	82-86	glycoprotein 1b, alpha polypeptide	Mus musculus	36-45
24969778-8	2014	PECAM-1-mediated internalization of GPIbalpha was reduced by inhibitors of dynamin (Dynasore) and glycogen synthase kinase-3 (CHIR99021), an effect that was enhanced in the presence of EGTA.	Egtazic Acid	185-189	platelet/endothelial cell adhesion molecule 1	Mus musculus	0-7
24969778-8	2014	PECAM-1-mediated internalization of GPIbalpha was reduced by inhibitors of dynamin (Dynasore) and glycogen synthase kinase-3 (CHIR99021), an effect that was enhanced in the presence of EGTA.	Egtazic Acid	185-189	glycoprotein 1b, alpha polypeptide	Mus musculus	36-45
24530450-8	2014	Both the pattern and density of label for Homer 1, the isoform that is ubiquitous in hippocampus, remained unchanged under high K(+) depolarization (90mM for 2-5min), N-methyl-d-asparic acid (NMDA) treatment (50muM for 2min), and calcium-free conditions (EGTA at 1mM for 2min).	Egtazic Acid	255-259	homer scaffolding protein 1	Mus musculus	42-49
24641282-7	2014	The enhancement was dependent upon Ca2+ influx and was abolished in the presence of EGTA, the Ca2+ channel inhibitor SKF96365, the transient receptor potential (TRP) channel blocker ruthenium red, and the TRPV1 antagonists capsazepine and AMG9810.	Egtazic Acid	84-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	205-210
24961950-5	2014	As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs.	Egtazic Acid	107-111	mitogen-activated protein kinase 8	Homo sapiens	178-181
24961950-5	2014	As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs.	Egtazic Acid	107-111	mitogen-activated protein kinase 14	Homo sapiens	186-189
24961950-5	2014	As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs.	Egtazic Acid	107-111	caspase 9	Homo sapiens	251-260
24961950-5	2014	As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs.	Egtazic Acid	107-111	caspase 3	Homo sapiens	266-275
24641279-8	2014	SKF 96365 arrested the glioblastoma cells in the S and G2 phases and activated p38-MAPK and JNK, which were all prevented by the Ca(2+) chelator BAPTA-AM or EGTA.	Egtazic Acid	157-161	mitogen-activated protein kinase 14	Homo sapiens	79-82
24641279-8	2014	SKF 96365 arrested the glioblastoma cells in the S and G2 phases and activated p38-MAPK and JNK, which were all prevented by the Ca(2+) chelator BAPTA-AM or EGTA.	Egtazic Acid	157-161	mitogen-activated protein kinase 8	Homo sapiens	92-95
24038189-5	2014	In the present study, VDR in the various cells from neonatal and adult mouse bone tissues was identified by a highly specific and sensitive immunohistochemistry method following bone decalcification with EGTA.	Egtazic Acid	204-208	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	22-25
24375019-4	2014	The effect of SIN-1 was completely occluded either in the presence of the calcium chelator EGTA or the non-selective calcium channel antagonist Cd(2+).	Egtazic Acid	91-95	MAPK associated protein 1	Homo sapiens	14-19
24398874-8	2014	Sperm motility and velocity were reduced in ASW or 5-HT containing EGTA or W-7, suggesting that extracellular Ca(2)(+) is required for Ca(2)(+)/calmodulin-dependent flagellar beating.	Egtazic Acid	67-71	calmodulin	Crassostrea gigas	144-154
23899746-9	2013	Chelation of extracellular Ca(2+) (EGTA; 1mM) or intracellular Ca(2+) (BAPTA; 5muM) significantly reduced secreted BDNF, as did the knockdown of SOCE proteins STIM1 and Orai1 or plasma membrane caveolin-1.	Egtazic Acid	35-39	brain derived neurotrophic factor	Homo sapiens	115-119
23782309-9	2014	It was also observed that the ability of BPA to enhance histamine and CysLT release was inhibited by blocking the extracellular signal-regulated kinase (ERK) pathway with U0126 or by chelating extracellular calcium (Ca(2+)) using EGTA.	Egtazic Acid	230-234	mitogen-activated protein kinase 1	Homo sapiens	153-156
23830920-4	2013	A Ca(2+) chelator, ethylene glycol tetraacetic acid (EGTA), reduced ATP-induced TNF-alpha release, suggesting that intracellular Ca(2+) is important in this response.	Egtazic Acid	19-51	tumor necrosis factor	Mus musculus	80-89
23830920-4	2013	A Ca(2+) chelator, ethylene glycol tetraacetic acid (EGTA), reduced ATP-induced TNF-alpha release, suggesting that intracellular Ca(2+) is important in this response.	Egtazic Acid	53-57	tumor necrosis factor	Mus musculus	80-89
24269630-5	2014	It appears that hsBAFF-mediated PP2A-Erk1/2 pathway and B-cell proliferation/viability was Ca(2+)-dependent, as pretreatment with BAPTA/AM, EGTA or 2-APB significantly attenuated these events.	Egtazic Acid	140-144	protein phosphatase 2 phosphatase activator	Homo sapiens	32-43
24218893-5	2013	RESULTS: The level of IL-2 in Jurkat T cells exposed to 100 microg/ml PM2.5 was significantly lower than parallel groups, but higher than PM2.5 + CSA group and PM2.5 + EGTA group (P &lt; 0.05).	Egtazic Acid	168-172	interleukin 2	Homo sapiens	22-26
24636300-10	2013	EGTA and 2-APB also increased the ethanol-treated cells" viability and reduced the ALT and AST leakage.	Egtazic Acid	0-4	solute carrier family 17 member 5	Homo sapiens	91-94
23981677-0	2013	Adsorption of Cd(II) and Pb(II) by a novel EGTA-modified chitosan material: kinetics and isotherms.	Egtazic Acid	43-47	submaxillary gland androgen regulated protein 3B	Homo sapiens	25-31
23981677-2	2013	The adsorption capability of EGTA-modified chitosan was investigated by the removal of Cd(II) and Pb(II) from aqueous solutions.	Egtazic Acid	29-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	98-104
23981677-7	2013	The kinetics of Cd(II) and Pb(II) on EGTA-chitosan complied with the pseudo-second-order model and the adsorption rate was also influenced by intra-particle diffusion.	Egtazic Acid	37-41	submaxillary gland androgen regulated protein 3B	Homo sapiens	27-33
23981677-9	2013	The extended form of the BiLangmuir model was tested for the modeling of two-component adsorption equilibrium of Cd(II) and Pb(II) on EGTA-chitosan.	Egtazic Acid	134-138	submaxillary gland androgen regulated protein 3B	Homo sapiens	124-130
23857079-5	2013	To clarify how MEKK1 becomes active in response to cold stress signaling, MEKK1 phosphorylation was monitored by an enzyme extracted from the seedlings grown under cold stress with or without EGTA.	Egtazic Acid	192-196	MAPK/ERK kinase kinase 1	Arabidopsis thaliana	15-20
23857079-5	2013	To clarify how MEKK1 becomes active in response to cold stress signaling, MEKK1 phosphorylation was monitored by an enzyme extracted from the seedlings grown under cold stress with or without EGTA.	Egtazic Acid	192-196	MAPK/ERK kinase kinase 1	Arabidopsis thaliana	74-79
23857079-7	2013	MKK2 was also phosphorylated by the same extract, but only when EGTA was absent.	Egtazic Acid	64-68	MAP kinase kinase 2	Arabidopsis thaliana	0-4
24006483-8	2013	Unexpectedly, Jurkat CD47 null cells exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+)/ethylene glycol tetraacetic acid treatment.	Egtazic Acid	136-168	CD47 molecule	Homo sapiens	21-25
24006483-8	2013	Unexpectedly, Jurkat CD47 null cells exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+)/ethylene glycol tetraacetic acid treatment.	Egtazic Acid	136-168	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	68-73
24006483-8	2013	Unexpectedly, Jurkat CD47 null cells exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+)/ethylene glycol tetraacetic acid treatment.	Egtazic Acid	136-168	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	78-83
23884142-11	2013	Reducing extracellular calcium with EGTA increased renin release (0.35 +- 0.08 mug AngI/ml/mg prot; P &lt; 0.01), and blocked renin inhibition by CHA (0.28 +- 0.06 mug AngI/ml/mg prot; P &lt; 0.	Egtazic Acid	36-40	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	83-87
23884142-11	2013	Reducing extracellular calcium with EGTA increased renin release (0.35 +- 0.08 mug AngI/ml/mg prot; P &lt; 0.01), and blocked renin inhibition by CHA (0.28 +- 0.06 mug AngI/ml/mg prot; P &lt; 0.	Egtazic Acid	36-40	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	168-172
24051401-4	2013	GA-induced GRP78 expression is significantly decreased in the presence of BAPTA/AM, EGTA and RR, suggesting that the calcium influx from the extracellular space and intracellular calcium store oscillations are contributed to by the calcium mobilization and GRP78 expression induced by GA.	Egtazic Acid	84-88	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	11-16
24039860-9	2013	We conclude that in vitro, Rap1A may be important for steady state barrier integrity, while Rap1B is involved more in dynamic junctional responses such as resistance to junctional disassembly induced by EGTA and reassembly of cell junctions following disruption.	Egtazic Acid	203-207	RAS related protein 1b	Mus musculus	92-97
23928916-8	2013	Combined with the effect of EGTA, these results suggest that the Ca (2+) domains of several KCa1.1-Cav3 complexes need to cooperate to generate sufficient [Ca (2+)]i, despite the physical association between KCa1.1 and Cav3 channels.	Egtazic Acid	28-32	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	92-98
23928916-8	2013	Combined with the effect of EGTA, these results suggest that the Ca (2+) domains of several KCa1.1-Cav3 complexes need to cooperate to generate sufficient [Ca (2+)]i, despite the physical association between KCa1.1 and Cav3 channels.	Egtazic Acid	28-32	caveolin 3	Homo sapiens	99-103
23943848-8	2013	The acs7-1 mutant exhibited less sensitivity to the inhibition of root gravitropism by treatment with the calcium chelator ethylene glycol tetraacetic acid (EGTA).	Egtazic Acid	123-155	1-amino-cyclopropane-1-carboxylate synthase 7	Arabidopsis thaliana	4-8
23943848-8	2013	The acs7-1 mutant exhibited less sensitivity to the inhibition of root gravitropism by treatment with the calcium chelator ethylene glycol tetraacetic acid (EGTA).	Egtazic Acid	157-161	1-amino-cyclopropane-1-carboxylate synthase 7	Arabidopsis thaliana	4-8
23661501-8	2013	Interestingly, the restriction of CRISP2 at the EqS was diminished when EGTA was present in the media, indicating that Ca(2+) is required for maintaining CRISP2 at the EqS.	Egtazic Acid	72-76	cysteine rich secretory protein 2	Homo sapiens	34-40
23870258-4	2013	Addition of either EGTA or BAPTA to the cis hemi-chamber, representing the cytoplasmic domain of the channel, and lowering Ca(2+) to ~0.6-0.8 nM, inhibited spontaneous PC2hst channel activity, with a time response dependent on the chelator tested.	Egtazic Acid	19-23	polycystin 2, transient receptor potential cation channel	Homo sapiens	168-171
23870258-5	2013	EGTA reduced PC2hst channel currents by 86%, with a t1/2 = 3.6 min, whereas BAPTA rapidly and completely (100%) eliminated channel activity with a t1/2 = 0.8 min.	Egtazic Acid	0-4	polycystin 2, transient receptor potential cation channel	Homo sapiens	13-16
23608524-5	2013	DAGK activity, measured in terms of phosphatidic acid formation from a) [(3)H]DAG and ATP in the presence of EGTA and R59022, a type I DAGK inhibitor, or b) [gamma-(32)P]ATP and 1-stearoyl, 2-arachidonoylglycerol (SAG), was found to be significantly higher in BBROS than in BDROS.	Egtazic Acid	109-113	diacylglycerol kinase, beta	Rattus norvegicus	0-4
23661501-8	2013	Interestingly, the restriction of CRISP2 at the EqS was diminished when EGTA was present in the media, indicating that Ca(2+) is required for maintaining CRISP2 at the EqS.	Egtazic Acid	72-76	cysteine rich secretory protein 2	Homo sapiens	154-160
23485152-4	2013	Hcy-induced COX-2 expression was attenuated not only by the calcium chelators, EGTA and BAPTA-AM, but also by an antioxidant, N-acetylcysteine.	Egtazic Acid	79-83	cytochrome c oxidase II, mitochondrial	Mus musculus	12-17
23675369-5	2013	Furthermore, addition of the calcium chelator, EGTA, or exposure of cells to the non-selective Ca(2+) channel blocker, NiCl2, significantly attenuated the PACAP-evoked [Ca(2+)]i increase.	Egtazic Acid	47-51	adenylate cyclase activating polypeptide 1	Rattus norvegicus	155-160
25310348-5	2013	Gyp-increased [Ca(2+)]i level was partly inhibited by removal of extracellular Ca(2+) by Ca(2+) chelator EGTA, store-operated Ca(2+) channel (SOC) inhibitor 2- aminoethoxydiphenyl borate (2-APB), and ER Ca(2+)-release-antagonist 3,4,5-trimethoxybenzoic acid 8-(diethylamino) octyl ester (TMB-8).	Egtazic Acid	105-109	glycophorin B (MNS blood group)	Homo sapiens	0-3
25310348-7	2013	EGTA, 2-APB, and TMB-8 also protected against Gyp-induced apoptosis in HepG2 cells.	Egtazic Acid	0-4	glycophorin B (MNS blood group)	Homo sapiens	46-49
23557796-5	2013	Sequentially, we observed that preventing [Ca(2+)]i elevation using EGTA or 2-APB dramatically inhibited hsBAFF activation of mTOR signaling, as well as cell growth and survival, suggesting that hsBAFF-induced extracellular Ca(2+) influx and ER Ca(2+) release elevates [Ca(2+)]i contributing to B lymphocyte proliferation and survival via activation of mTOR signaling.	Egtazic Acid	68-72	mechanistic target of rapamycin kinase	Homo sapiens	126-130
23557796-5	2013	Sequentially, we observed that preventing [Ca(2+)]i elevation using EGTA or 2-APB dramatically inhibited hsBAFF activation of mTOR signaling, as well as cell growth and survival, suggesting that hsBAFF-induced extracellular Ca(2+) influx and ER Ca(2+) release elevates [Ca(2+)]i contributing to B lymphocyte proliferation and survival via activation of mTOR signaling.	Egtazic Acid	68-72	mechanistic target of rapamycin kinase	Homo sapiens	353-357
22964480-2	2013	Treatment with the calcium chelator EGTA inhibited constitutive as well as HDAC-inhibitor induced MICA/B and ULBP2 cell surface expression on melanoma cells and Jurkat T-cells.	Egtazic Acid	36-40	histone deacetylase 9	Homo sapiens	75-79
23626738-4	2013	Cav3 calcium influx induced a 50 mV negative shift in KCa1.1 voltage for activation, an interaction that was blocked by Cav3 or KCa1.1 channel blockers, or high internal EGTA.	Egtazic Acid	170-174	caveolin 3	Homo sapiens	0-4
23626738-4	2013	Cav3 calcium influx induced a 50 mV negative shift in KCa1.1 voltage for activation, an interaction that was blocked by Cav3 or KCa1.1 channel blockers, or high internal EGTA.	Egtazic Acid	170-174	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	54-60
23232625-8	2013	At confluence, Spry2 expression correlates with intact cell-cell contacts, whereas disruption of cell-cell contacts by EGTA, TNFalpha and thrombin decreases Spry2 protein expression.	Egtazic Acid	119-123	sprouty RTK signaling antagonist 2	Mus musculus	157-162
23266505-9	2013	The upregulation of calpain, tBid and caspase-3 activity were further inhibited by treatment with EGTA in the presence of ALD.	Egtazic Acid	98-102	caspase 3	Rattus norvegicus	38-47
23266505-10	2013	Additionally, AIF levels in the cytosol decreased due to EGTA but not due to calpeptin.	Egtazic Acid	57-61	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	14-17
22964480-2	2013	Treatment with the calcium chelator EGTA inhibited constitutive as well as HDAC-inhibitor induced MICA/B and ULBP2 cell surface expression on melanoma cells and Jurkat T-cells.	Egtazic Acid	36-40	UL16 binding protein 2	Homo sapiens	109-114
23095108-9	2013	RESULTS: While KCl caused a significant increase in CGRP secretion that was significantly repressed by treatment with ethylene glycol tetraacetic acid (EGTA), onabotulinumtoxinA, and rizatriptan, the stimulatory effect of protons (pH 5.5) was not suppressed by EGTA, onabotulinumtoxinA, or rizatriptan.	Egtazic Acid	118-150	calcitonin related polypeptide alpha	Homo sapiens	52-56
23073616-4	2013	During both extracellular Ca(2+) depletion caused by EGTA treatment and Ca(2+) repletion after Ca(2+) starvation, the expression of tricellulin increased in whole lysates and in Triton-X-100-insoluble fractions without any change in its mRNA.	Egtazic Acid	53-57	MARVEL domain containing 2	Homo sapiens	132-143
23095108-9	2013	RESULTS: While KCl caused a significant increase in CGRP secretion that was significantly repressed by treatment with ethylene glycol tetraacetic acid (EGTA), onabotulinumtoxinA, and rizatriptan, the stimulatory effect of protons (pH 5.5) was not suppressed by EGTA, onabotulinumtoxinA, or rizatriptan.	Egtazic Acid	152-156	calcitonin related polypeptide alpha	Homo sapiens	52-56
23095108-9	2013	RESULTS: While KCl caused a significant increase in CGRP secretion that was significantly repressed by treatment with ethylene glycol tetraacetic acid (EGTA), onabotulinumtoxinA, and rizatriptan, the stimulatory effect of protons (pH 5.5) was not suppressed by EGTA, onabotulinumtoxinA, or rizatriptan.	Egtazic Acid	261-265	calcitonin related polypeptide alpha	Homo sapiens	52-56
23958191-9	2013	Maximal PMCA4 microsomal activity was achieved in the TR-FRET assay with 15ng/mul microsomal concentration, 30-minute pre-incubation with compounds at 37 C, and calcium buffering with 1mM EGTA providing 1muM free-calcium.	Egtazic Acid	188-192	ATPase plasma membrane Ca2+ transporting 4	Homo sapiens	8-13
23228260-9	2013	Calcium chloride addition without MTA presented a significant increase of mRNA levels of Runx2, osterix, and Sox9; ethylene glycol tetraacetic acid addition with MTA presented a significant increase of mRNA levels of MyoD and LPL.	Egtazic Acid	115-147	myogenic differentiation 1	Mus musculus	217-221
23228260-9	2013	Calcium chloride addition without MTA presented a significant increase of mRNA levels of Runx2, osterix, and Sox9; ethylene glycol tetraacetic acid addition with MTA presented a significant increase of mRNA levels of MyoD and LPL.	Egtazic Acid	115-147	lipoprotein lipase	Mus musculus	226-229
22913344-10	2013	S1P (5x10(-7)  M) also induced significant tonic contractions in the lymph vessels that had been superfused with high K(+)  Krebs-bicarbonate solution or Ca(2+) -free high K(+)  Krebs solution containing 1 mM EGTA.	Egtazic Acid	209-213	sphingosine-1-phosphate receptor 1	Mus musculus	0-3
22872152-5	2012	METHODS AND RESULTS: Cell swelling induced by hyposmotic bath solution stimulated Cl(-) currents in arterial myocytes that were blocked by TMEM16A channel inhibitory antibodies, RNAi-mediated selective TMEM16A channel knockdown, removal of extracellular calcium (Ca(2+)), replacement of intracellular EGTA with BAPTA, a fast Ca(2+) chelator, and Gd(3+) and SKF-96365, nonselective cation channel blockers.	Egtazic Acid	301-305	anoctamin 1	Homo sapiens	202-209
22966160-7	2012	Stimulation by PIP(2) injection was mimicked by injecting IP(3), but inhibited by either applying the phospholipase C (PLC) inhibitor U73112 or depleting ER Ca(2+) with prolonged thapsigargin/EGTA treatment.	Egtazic Acid	192-196	prolactin induced protein	Rattus norvegicus	15-18
22878643-8	2012	Western blot analysis showed that CI-IB-MECA induced the down-regulation of extracellular signal-regulated kinases (ERK) and Akt, which was prevented by EGTA, NAC, and the A3AR antagonist MRS1191.	Egtazic Acid	153-157	mitogen-activated protein kinase 1	Homo sapiens	76-114
22878643-8	2012	Western blot analysis showed that CI-IB-MECA induced the down-regulation of extracellular signal-regulated kinases (ERK) and Akt, which was prevented by EGTA, NAC, and the A3AR antagonist MRS1191.	Egtazic Acid	153-157	mitogen-activated protein kinase 1	Homo sapiens	116-119
22878643-8	2012	Western blot analysis showed that CI-IB-MECA induced the down-regulation of extracellular signal-regulated kinases (ERK) and Akt, which was prevented by EGTA, NAC, and the A3AR antagonist MRS1191.	Egtazic Acid	153-157	AKT serine/threonine kinase 1	Homo sapiens	125-128
22856685-6	2012	No binding is observed in buffer with 6 mM Mg(2+) and 1 mM EGTA that chelates Ca(2+), suggesting high specificity of the CaM-ribosome interaction dependent on the Ca(2+) induced conformational change of CaM.	Egtazic Acid	59-63	calmodulin 1	Homo sapiens	121-124
22778093-13	2012	IL-1beta processing was dependent upon Ca(2+) uptake from the extracellular medium and intracellular Ca(2+) oscillations, as determined by EGTA and BAPTA-AM [1,2-bis(2-aminophenoxy) ethane-N,N,N",N"-tetraacetic acid tetrakis (acetoxymethyl ester)] treatments.	Egtazic Acid	139-143	interleukin 1 beta	Bos taurus	0-8
22626861-9	2012	Depletion of Ca2+ by EGTA markedly inhibited this Ca2+ influx and attenuated RhoA activation as well.	Egtazic Acid	21-25	ras homolog family member A	Homo sapiens	77-81
22718768-3	2012	The fluorescently labeled TnC was sensitive to both Ca(2+) dissociation and cross-bridge detachment at low Ca(2+) (presence of EGTA), allowing for a direct comparison between the two proposed rates of myofilament inactivation.	Egtazic Acid	127-131	tenascin C	Homo sapiens	26-29
22516131-10	2012	It was concluded that biofilm-forming ability varies strikingly depending on strain background, and that ClfB is involved in biofilm formation in the presence EGTA and citrate.	Egtazic Acid	159-163	AT695_RS04065	Staphylococcus aureus	105-109
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	hepatocyte nuclear factor 4 alpha	Homo sapiens	113-120
22527639-6	2012	In cells with lower (0.5 mM) intracellular [EGTA] resting [Ca2+] went from 0.35 +/- 0.08 muM in Ca2+-free external solution to 0.42 +/- 0.12 muM upon reapplication of Ca2+(n = 9).	Egtazic Acid	44-48	latexin	Homo sapiens	89-92
22527639-6	2012	In cells with lower (0.5 mM) intracellular [EGTA] resting [Ca2+] went from 0.35 +/- 0.08 muM in Ca2+-free external solution to 0.42 +/- 0.12 muM upon reapplication of Ca2+(n = 9).	Egtazic Acid	44-48	latexin	Homo sapiens	141-144
22422398-6	2012	The Ca(2+)-induced decline in Cx43 G(j) was prevented by pretreatment with calmidazolium or reversed by the addition of 10 mM EGTA to Ca(2+)-free extracellular solution, if Ca(2+) chelation was commenced before complete uncoupling, after which g(j) was only 60% recoverable.	Egtazic Acid	126-130	gap junction protein, alpha 3	Mus musculus	30-34
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	catenin beta 1	Homo sapiens	192-204
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	lymphoid enhancer binding factor 1	Homo sapiens	209-213
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	catenin beta 1	Homo sapiens	265-277
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	429-432
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	Yes1 associated transcriptional regulator	Homo sapiens	436-439
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	458-461
22391957-4	2012	EMT with proliferation by EGTA+EGF+FGF-2 was accompanied by activation of canonical Wnt signaling (judged by the TCF/LEF promoter activity, increased nuclear levels of and interaction between beta-catenin and LEF1 proteins, and the replication by overexpression of beta-catenin), abolished by concomitant addition of XAV939, a Wnt inhibitor, but not associated with suppression of Hippo signaling (negative expression of nuclear TAZ or YAP and cytoplasmic p-TAZ or p-YAP).	Egtazic Acid	26-30	Yes1 associated transcriptional regulator	Homo sapiens	467-470
22391957-5	2012	The causative role of Wnt signaling on EMT with proliferation was confirmed by overexpression of stable S33Y beta-catenin with EGTA treatment.	Egtazic Acid	127-131	catenin beta 1	Homo sapiens	109-121
22391957-6	2012	In addition, contact inhibition disrupted by EGTA in the presence of TGF-beta1 also led to EMT, but suppressed proliferation and Wnt signaling.	Egtazic Acid	45-49	transforming growth factor beta 1	Homo sapiens	69-78
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	Egtazic Acid	75-79	cadherin 2	Mus musculus	45-55
22289891-7	2012	Endocytosis of ADAMTS13 was completely blocked by the addition of EGTA and mannan.	Egtazic Acid	66-70	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	15-23
21988161-6	2012	AM251 also increased the amplitude of eIPSCs and decreased the paired-pulse ratio (PPR) in VP neurones-effects that were completely blocked with even low (1 mm EGTA) internal calcium chelation.	Egtazic Acid	160-164	arginine vasopressin	Rattus norvegicus	91-93
22382681-5	2012	Doxorubicin-induced TG2 activity was suppressed by treatment with caffeine at the early phase, N-acetylcysteine at the mid-phase, and EGTA at the late phase.	Egtazic Acid	134-138	transglutaminase 2	Homo sapiens	20-23
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	Egtazic Acid	75-79	thymoma viral proto-oncogene 1	Mus musculus	161-164
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	Egtazic Acid	75-79	glycogen synthase kinase 3 beta	Mus musculus	169-173
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	Egtazic Acid	75-79	Sp7 transcription factor 7	Mus musculus	192-199
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	Egtazic Acid	75-79	osteomodulin	Mus musculus	201-213
21964322-7	2012	Treatment of confluent MC3T3E1 cells with an N-cadherin junction inhibitor-EGTA and a PI3K inhibitor LY294002 resulted in reduction of phosphorylation levels of AKT and GSK3 and expression of Osterix, Osteomodulin and Osteoglycin.	Egtazic Acid	75-79	osteoglycin	Mus musculus	218-229
23285183-7	2012	Further more, we document that nNOS denitrosylation could be suppressed by pretreatment of neurons with MK801, an antagonist of NMDAR, GSNO, EGTA, BAPTA, W-7, an inhibitor of calmodulin as well as TrxR1 antisense oligonucleotide (AS-ODN) respectively.	Egtazic Acid	141-145	nitric oxide synthase 1	Homo sapiens	31-35
22049022-5	2012	When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination.	Egtazic Acid	62-94	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	125-130
22049022-5	2012	When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination.	Egtazic Acid	62-94	hematopoietic prostaglandin D synthase	Homo sapiens	135-141
22049022-5	2012	When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination.	Egtazic Acid	96-100	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	125-130
22049022-5	2012	When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination.	Egtazic Acid	96-100	hematopoietic prostaglandin D synthase	Homo sapiens	135-141
22049022-5	2012	When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination.	Egtazic Acid	220-224	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	125-130
22049022-5	2012	When the entry of calcium ion into the cells was inhibited by ethylene glycol tetraacetic acid (EGTA), the ubiquitination of COX-1 and H-PGDS was clearly suppressed; and the addition of CaCl(2) to the medium cleared the EGTA-mediated suppression of the ubiquitination.	Egtazic Acid	220-224	hematopoietic prostaglandin D synthase	Homo sapiens	135-141
22008253-3	2012	SNARE complexes comprising syntaxin 1, 25-kDa synaptosomal-associated protein (SNAP-25), and synaptobrevin 2 were coprecipitated with synaptotagmin I in the presence of ethylene glycol tetraacetic acid.	Egtazic Acid	169-201	synaptosome associated protein 25	Homo sapiens	79-86
22008253-3	2012	SNARE complexes comprising syntaxin 1, 25-kDa synaptosomal-associated protein (SNAP-25), and synaptobrevin 2 were coprecipitated with synaptotagmin I in the presence of ethylene glycol tetraacetic acid.	Egtazic Acid	169-201	vesicle associated membrane protein 2	Homo sapiens	93-108
22008253-3	2012	SNARE complexes comprising syntaxin 1, 25-kDa synaptosomal-associated protein (SNAP-25), and synaptobrevin 2 were coprecipitated with synaptotagmin I in the presence of ethylene glycol tetraacetic acid.	Egtazic Acid	169-201	synaptotagmin 1	Homo sapiens	134-149
22040951-4	2011	Finally the quiescent state and drug resistance properties of KG1a cells were determined after inhibiting N-cadherin-mediated cell-cell interaction by EGTA treatment.	Egtazic Acid	151-155	cadherin 2	Homo sapiens	106-116
22094966-9	2012	Both SOD and catalase showed differing sensitivities to EGTA and calcium.	Egtazic Acid	56-60	catalase	Oryctolagus cuniculus	13-21
21613605-5	2011	BAPTA was much more effective than EGTA at suppressing bTREK-1 inhibition by ANG II.	Egtazic Acid	35-39	ANG	Bos taurus	77-80
21867690-4	2011	Among them, AnxA6 was found to be almost EGTA-non extractable from matrix vesicles.	Egtazic Acid	41-45	annexin A6	Homo sapiens	12-17
21766850-5	2011	After incubation in EGTA solution, the average height of the protein changed to 2.26 +- 0.21 nm, indicating the conformational change of CaM to Apo-CaM.	Egtazic Acid	20-24	calmodulin 1	Homo sapiens	137-140
21766850-5	2011	After incubation in EGTA solution, the average height of the protein changed to 2.26 +- 0.21 nm, indicating the conformational change of CaM to Apo-CaM.	Egtazic Acid	20-24	calmodulin 1	Homo sapiens	148-151
21925388-3	2011	When cells are grown at low density or cells are detached by trypsinization or EGTA treatment, mature miR-141 is downregulated while miR-200c from a common primary transcript (pri-miR-200c~141) remains unaffected.	Egtazic Acid	79-83	microRNA 141	Homo sapiens	102-109
21925388-3	2011	When cells are grown at low density or cells are detached by trypsinization or EGTA treatment, mature miR-141 is downregulated while miR-200c from a common primary transcript (pri-miR-200c~141) remains unaffected.	Egtazic Acid	79-83	microRNA 200c	Homo sapiens	133-141
21613605-6	2011	When intracellular Ca(2+) concentration ([Ca(2+)](i)) was buffered to 20 nM with either 11 mM BAPTA or EGTA, ANG II (10 nM) inhibited bTREK-1 by 12.0 +- 4.5% (n=11) and 59.3 +- 8.4% (n=4), respectively.	Egtazic Acid	103-107	ANG	Bos taurus	109-112
21443188-5	2011	Chelation of [Ca(2+)](ext) or [Ca(2+)](intra) by EGTA or BAPTA attenuated tBHQ-induced HO-1.	Egtazic Acid	49-53	heme oxygenase 1	Homo sapiens	87-91
21482126-10	2011	It has been established that SOS3 protein senses Ca(2+) though the binding is very weak; we show the down regulation of BjSOS3 mRNA in presence of calcium chelator - EGTA under the various stress conditions including ABA.	Egtazic Acid	166-170	Calcium-binding EF-hand family protein	Arabidopsis thaliana	29-33
21687429-7	2011	The ehaJ gene lies immediately adjacent to a gene encoding a putative glycosyltransferase (referred to as egtA).	Egtazic Acid	106-110	glycosyl transferase	Escherichia coli	70-89
21781004-6	2011	The component of intracellular Ca2+ overload after EGTA treatment was prevented by IL-6 chronic exposure.	Egtazic Acid	51-55	interleukin 6	Homo sapiens	83-87
21443188-8	2011	Additionally, EGTA and BAPTA treatments decreased basal nuclear phosphorylation of CREB and decreased tBHQ-induced Nrf2-CBP binding and Nrf2 binding to enhancer as well as polymerase II binding to the promoter of HO-1 gene.	Egtazic Acid	14-18	cAMP responsive element binding protein 1	Homo sapiens	83-87
21443188-8	2011	Additionally, EGTA and BAPTA treatments decreased basal nuclear phosphorylation of CREB and decreased tBHQ-induced Nrf2-CBP binding and Nrf2 binding to enhancer as well as polymerase II binding to the promoter of HO-1 gene.	Egtazic Acid	14-18	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
21443188-8	2011	Additionally, EGTA and BAPTA treatments decreased basal nuclear phosphorylation of CREB and decreased tBHQ-induced Nrf2-CBP binding and Nrf2 binding to enhancer as well as polymerase II binding to the promoter of HO-1 gene.	Egtazic Acid	14-18	CREB binding protein	Homo sapiens	120-123
21443188-8	2011	Additionally, EGTA and BAPTA treatments decreased basal nuclear phosphorylation of CREB and decreased tBHQ-induced Nrf2-CBP binding and Nrf2 binding to enhancer as well as polymerase II binding to the promoter of HO-1 gene.	Egtazic Acid	14-18	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
21443188-8	2011	Additionally, EGTA and BAPTA treatments decreased basal nuclear phosphorylation of CREB and decreased tBHQ-induced Nrf2-CBP binding and Nrf2 binding to enhancer as well as polymerase II binding to the promoter of HO-1 gene.	Egtazic Acid	14-18	heme oxygenase 1	Homo sapiens	213-217
21544200-6	2011	Pretreatment with the extracellular Ca2+ chelator EGTA also prevented Cd-induced [Ca2+](i) elevation, MAPK/mTOR activation, as well as cell death, suggesting that Cd-induced extracellular Ca2+ influx plays a critical role in contributing to neuronal apoptosis.	Egtazic Acid	50-54	mitogen-activated protein kinase 3	Homo sapiens	102-106
21371434-6	2011	Extracellular (EGTA) or intracellular (BAPTA/AM) Ca(2+) chelator prevented the stretch-induced activation of TAK1.	Egtazic Acid	15-19	mitogen-activated protein kinase kinase kinase 7	Mus musculus	109-113
21502139-6	2011	Elimination of extracellular ATP with Apyrase, chelation of extracellular calcium with EGTA, or inhibition of P2X7 with oxidized ATP, all individually blocked intracellular calcium increase and Thy-1-stimulated adhesion.	Egtazic Acid	87-91	Thy-1 cell surface antigen	Homo sapiens	194-199
21461940-3	2011	Our aim was to detect the active sites of Cd2+ in the mitochondrial membrane treatments with cyclosporin A (CsA) and EGTA on the mitochondrial permeability transition (MPT) induced by low and high concentrations of Cd2+.	Egtazic Acid	117-121	Cd2 molecule	Rattus norvegicus	42-45
21461940-3	2011	Our aim was to detect the active sites of Cd2+ in the mitochondrial membrane treatments with cyclosporin A (CsA) and EGTA on the mitochondrial permeability transition (MPT) induced by low and high concentrations of Cd2+.	Egtazic Acid	117-121	Cd2 molecule	Rattus norvegicus	215-218
21544200-6	2011	Pretreatment with the extracellular Ca2+ chelator EGTA also prevented Cd-induced [Ca2+](i) elevation, MAPK/mTOR activation, as well as cell death, suggesting that Cd-induced extracellular Ca2+ influx plays a critical role in contributing to neuronal apoptosis.	Egtazic Acid	50-54	mechanistic target of rapamycin kinase	Homo sapiens	107-111
21544200-9	2011	Pretreatment with BAPTA/AM, EGTA or TFP attenuated Cd-induced ROS and cleavage of caspase-3 in the neuronal cells.	Egtazic Acid	28-32	caspase 3	Homo sapiens	82-91
21051692-11	2011	Visible disease occurred and progressed only in aged, blotted, and EGTA-treated, SP-D knockout mice.	Egtazic Acid	67-71	surfactant associated protein D	Mus musculus	81-85
20947498-5	2010	Disrupting homotypic VE-cadherin interactions with EGTA, antibodies to the extracellular domain of VE-cadherin, or gene silencing all resulted in decreased Akt (but not Erk1/2) activation.	Egtazic Acid	51-55	cadherin 5	Homo sapiens	21-32
21292685-7	2011	In addition, omitting Ca(2+) from the external medium using ethylene glycol tetraacetic acid markedly inhibited this cell death, reducing the protein levels of CHOP and DR5.	Egtazic Acid	60-92	DNA damage inducible transcript 3	Homo sapiens	160-164
21292685-7	2011	In addition, omitting Ca(2+) from the external medium using ethylene glycol tetraacetic acid markedly inhibited this cell death, reducing the protein levels of CHOP and DR5.	Egtazic Acid	60-92	TNF receptor superfamily member 10b	Homo sapiens	169-172
21734444-0	2011	Prevention of amyloid-beta oligomer-induced neuronal death by EGTA, estradiol, and endocytosis inhibitor.	Egtazic Acid	62-66	amyloid beta precursor protein	Homo sapiens	14-26
21126059-7	2010	Moreover, AKHR-induced ERK1/2 phosphorylation was blocked by the calcium chelators EGTA and BAPTA-AM.	Egtazic Acid	83-87	mitogen-activated protein kinase 3	Homo sapiens	23-29
21145253-7	2011	Subsequently, we revealed that hsBAFF-stimulated CD4(+) T cell proliferation was markedly suppressed after pretreatment with EGTA, an extracellular Ca(2+) chelator, or with 2-APB, an inhibitor of Ca(2+) influx through CRAC channels, respectively, suggesting that extracellular Ca(2+) influx due to hsBAFF is closely associated with [Ca(2+)](i) elevation contributing to CD4(+) T cell proliferation.	Egtazic Acid	125-129	CD4 antigen	Mus musculus	49-52
21145253-7	2011	Subsequently, we revealed that hsBAFF-stimulated CD4(+) T cell proliferation was markedly suppressed after pretreatment with EGTA, an extracellular Ca(2+) chelator, or with 2-APB, an inhibitor of Ca(2+) influx through CRAC channels, respectively, suggesting that extracellular Ca(2+) influx due to hsBAFF is closely associated with [Ca(2+)](i) elevation contributing to CD4(+) T cell proliferation.	Egtazic Acid	125-129	CD4 molecule	Homo sapiens	370-373
21085670-9	2010	EGTA chelation of indigenous mucin crosslinkers (Ca(2+) ions) was unable to effectively disperse NP-induced aggregated mucins.	Egtazic Acid	0-4	LOC100508689	Homo sapiens	29-34
20816837-10	2010	Ca(2+)-chelation with BAPTA + EGTA reduced Shh expression.	Egtazic Acid	30-34	sonic hedgehog	Mus musculus	43-46
20800074-8	2010	The PK2-induced inhibition of I(GABA) was removed by intracellular dialysis of either GDP-beta-S (a non-hydrolyzable GDP analog), EGTA (a Ca2+ chelator) or GF109203X (a selective protein kinase C inhibitor), but not by H89 (a protein kinase A inhibitor).	Egtazic Acid	130-134	prokineticin 2	Rattus norvegicus	4-7
20941751-0	2010	An EF-hands protein, centrin-1, is an EGTA-sensitive SUMO-interacting protein in mouse testis.	Egtazic Acid	38-42	centrin 1	Mus musculus	21-30
20713550-4	2010	Thapsigargin-induced up-regulation of ATF3 expression in keratinocytes was attenuated by BAPTA-acetoxymethyl ester or by expression of the Ca(2+)-binding protein parvalbumin in the cytosol of HaCaT cells but not by a panel of pharmacological agents that chelate extracellular Ca(2+) (EGTA) or inhibit either ryanodine receptors (dantrolene) or voltage-gated Ca(2+) channels (nifedipine).	Egtazic Acid	284-288	activating transcription factor 3	Homo sapiens	38-42
20713550-4	2010	Thapsigargin-induced up-regulation of ATF3 expression in keratinocytes was attenuated by BAPTA-acetoxymethyl ester or by expression of the Ca(2+)-binding protein parvalbumin in the cytosol of HaCaT cells but not by a panel of pharmacological agents that chelate extracellular Ca(2+) (EGTA) or inhibit either ryanodine receptors (dantrolene) or voltage-gated Ca(2+) channels (nifedipine).	Egtazic Acid	284-288	parvalbumin	Homo sapiens	162-173
20941751-3	2010	In bead halo assays, the interaction between centrin-1 and SUMO-2/3 was reduced in the presence of EGTA and facilitated by the addition of CaCl2.	Egtazic Acid	99-103	centrin 1	Mus musculus	45-54
20941751-3	2010	In bead halo assays, the interaction between centrin-1 and SUMO-2/3 was reduced in the presence of EGTA and facilitated by the addition of CaCl2.	Egtazic Acid	99-103	small ubiquitin-like modifier 2	Mus musculus	59-65
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Egtazic Acid	35-39	centrin 1	Mus musculus	18-27
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Egtazic Acid	35-39	small ubiquitin-like modifier 2	Mus musculus	50-56
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Egtazic Acid	35-39	centrin 1	Mus musculus	136-145
20941751-5	2010	Identification of centrin-1 as the EGTA-sensitive SUMO-2/3-interacting protein indicates the possible role of calcium in modulating the centrin-1-SUMO-2/3 interaction and suggests the importance of this interaction in mouse testis.	Egtazic Acid	35-39	small ubiquitin-like modifier 2	Mus musculus	146-152
20454859-6	2010	Incubation with 1 mM EGTA to decrease extracellular [Ca(2+)] prevented cardiomyocyte apoptosis induced by hyperosmotic stress, while overexpression of an adenoviral dominant negative form of CREB abolished the cardioprotection provided by 1 mM EGTA.	Egtazic Acid	21-25	cAMP responsive element binding protein 1	Homo sapiens	191-195
20454859-6	2010	Incubation with 1 mM EGTA to decrease extracellular [Ca(2+)] prevented cardiomyocyte apoptosis induced by hyperosmotic stress, while overexpression of an adenoviral dominant negative form of CREB abolished the cardioprotection provided by 1 mM EGTA.	Egtazic Acid	244-248	cAMP responsive element binding protein 1	Homo sapiens	191-195
20452974-8	2010	Additionally, induction of Arc/Arg3.1 also involved the upstream release of intracellular calcium stores, an effect that could be blocked by thapsigargin but not by EGTA.	Egtazic Acid	165-169	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	27-37
20599720-7	2010	Experiments using BAPTA/AM and EGTA, and Ca2+ imaging suggested that the LPS-induced increase in [Ca2+]i involves both the TRPV2-mediated intracellular and extracellular Ca2+ mobilizations.	Egtazic Acid	31-35	transient receptor potential cation channel subfamily V member 2	Homo sapiens	123-128
20599720-8	2010	BAPTA/AM abolished LPS-induced TNFalpha and IL-6 production, while EGTA only partially suppressed LPS-induced IL-6 production, but not TNFalpha production.	Egtazic Acid	67-71	interleukin 6	Homo sapiens	110-114
20381461-10	2010	On the other hand, mechanical injury produced an [Ca(2+)](i) wave propagation that was partially inhibited by siRNA-CaSR, NPS2390 and the extracellular Ca(2+) chelator EGTA, which suggest a link of CaSR between cell-cell communication and wound repair in differentiated HBEC.	Egtazic Acid	168-172	calcium sensing receptor	Homo sapiens	198-202
21532911-6	2010	Chelation of intracellular calcium with BAPTA or extracellular calcium with EGTA completely abrogated neutrophil adhesion to ICAM-1.	Egtazic Acid	76-80	intercellular adhesion molecule 1	Homo sapiens	125-131
20450878-5	2010	Incubation of cells with 2-APB or in a nominally Ca(2+)-free medium plus EGTA showed that Akt phosphorylation by ATP depends on intracellular calcium release but is independent of calcium influx.	Egtazic Acid	73-77	AKT serine/threonine kinase 1	Homo sapiens	90-93
20602801-5	2010	RESULTS: The transient rise in intracellular Ca2+ induced by agonists for FPR1 or FPR2 in human neutrophils occurred also in the presence of a chelator of Ca2+ (EGTA).	Egtazic Acid	161-165	formyl peptide receptor 1	Homo sapiens	74-78
20602801-5	2010	RESULTS: The transient rise in intracellular Ca2+ induced by agonists for FPR1 or FPR2 in human neutrophils occurred also in the presence of a chelator of Ca2+ (EGTA).	Egtazic Acid	161-165	formyl peptide receptor 2	Homo sapiens	82-86
20630211-10	2010	We observed a decrease in milk casein, which was associated with a decrease in the mRNA level of kappa-casein in the lactose-infused glands, and a decrease in milk lactose, which was associated with a downregulation of alpha-lactalbumin transcripts in both the EGTA- and lactose-treated glands.	Egtazic Acid	261-265	alpha-lactalbumin	Capra hircus	219-236
20348036-9	2010	In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).	Egtazic Acid	102-167	formyl peptide receptor 1	Homo sapiens	53-57
20348036-9	2010	In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).	Egtazic Acid	102-167	integrin subunit alpha M	Homo sapiens	66-71
20348036-9	2010	In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).	Egtazic Acid	169-173	formyl peptide receptor 1	Homo sapiens	53-57
20348036-9	2010	In addition, ropivacaine more potently inhibited the fMLP-induced CD11b expression in the presence of ethylene glycol-bis(2-aminoethylether)-N,N,N ,N -tetraacetic acid (EGTA), a chelator of extracellular Ca(2+).	Egtazic Acid	169-173	integrin subunit alpha M	Homo sapiens	66-71
20079824-5	2010	Additionally, POX up-regulated caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibited POX-induced increase of caspase-12 expression.	Egtazic Acid	104-108	caspase 12	Mus musculus	31-41
20082607-4	2010	Pre-incubation of cells with either the calcium antagonist verapamil (10(-5) mol L(-1)) or the calcium chelator Egtazic (EGTA, 0.1 mmol L(-1)) significantly suppressed motilin (10(-6) mol L(-1)) induced [Ca(2+)](i) increase as indicated by fluorescent intensity.	Egtazic Acid	121-125	motilin	Rattus norvegicus	168-175
20079824-5	2010	Additionally, POX up-regulated caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibited POX-induced increase of caspase-12 expression.	Egtazic Acid	104-108	caspase 12	Mus musculus	178-188
20141114-4	2010	As an example, we show that calcium-dependent displacement of Mn(2+) ions bound to EGTA and BAPTA results in a T(1)-weighted MRI signal increase, whereas displacement from calmodulin results in a signal decrease.	Egtazic Acid	83-87	calmodulin 1	Homo sapiens	172-182
20010694-5	2010	The N-module can be dissociated with EGTA to form the half-loaded Munc13/Ca(2+)(2)-CaM complex.	Egtazic Acid	37-41	calmodulin 1	Homo sapiens	83-86
20215102-4	2010	Both extra- and intracellular calcium ion signalling were implicated in gonadotropin-induced ERK1/2 activation as treatment with either the calcium chelator EGTA or an inhibitor of intracellular calcium release, dantrolene, inhibited gonadotropin-induced ERK1/2 activation.	Egtazic Acid	157-161	mitogen-activated protein kinase 3	Homo sapiens	93-99
20215102-4	2010	Both extra- and intracellular calcium ion signalling were implicated in gonadotropin-induced ERK1/2 activation as treatment with either the calcium chelator EGTA or an inhibitor of intracellular calcium release, dantrolene, inhibited gonadotropin-induced ERK1/2 activation.	Egtazic Acid	157-161	mitogen-activated protein kinase 3	Homo sapiens	255-261
20035709-1	2010	The plasma membrane Ca2+ ATPase catalyzed the hydrolysis of ATP in the presence of millimolar concentrations of EGTA and no added Ca2+ at a rate near 1.5% of that attained at saturating concentrations of Ca2+.	Egtazic Acid	112-116	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	4-31
19688259-4	2010	EGTA increased GRP78 protein expression, suggesting that EGTA induces ER stress.	Egtazic Acid	0-4	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	15-20
19688259-4	2010	EGTA increased GRP78 protein expression, suggesting that EGTA induces ER stress.	Egtazic Acid	57-61	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	15-20
20010694-5	2010	The N-module can be dissociated with EGTA to form the half-loaded Munc13/Ca(2+)(2)-CaM complex.	Egtazic Acid	37-41	unc-13 homolog B	Homo sapiens	66-72
19857473-6	2010	By western blotting, proline-rich tyrosine kinase 2 (PYK2) was phosphorylated at Tyr-402 in response to CKLF1 and this phosphorylation was apparently suppressed by phospholipase C-gamma inhibitor U73122, but not extracellular Ca(2+) chelator EGTA.	Egtazic Acid	242-246	protein tyrosine kinase 2 beta	Homo sapiens	53-57
19857473-6	2010	By western blotting, proline-rich tyrosine kinase 2 (PYK2) was phosphorylated at Tyr-402 in response to CKLF1 and this phosphorylation was apparently suppressed by phospholipase C-gamma inhibitor U73122, but not extracellular Ca(2+) chelator EGTA.	Egtazic Acid	242-246	chemokine like factor	Homo sapiens	104-109
19931333-4	2010	To elucidate the mechanism of the cleavage of caspase-4 under ER stress, we used EGTA, a Ca(2+) chelator, because the cleavage caspase-12 has reported to be regulated by the calpain.	Egtazic Acid	81-85	caspase 4	Homo sapiens	46-55
20071512-6	2010	Cav1.3 channel deficiency decreased the number of normally firing MCCs (30%; 2.0 Hz), suggesting a critical role of these channels on firing, which derived from their slow inactivation rate, sizeable activation at subthreshold potentials, and close coupling to fast inactivating BK channels as determined by using EGTA and BAPTA Ca(2+) buffering.	Egtazic Acid	314-318	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	0-6
19931333-5	2010	As the results, EGTA inhibited the cleavage of caspase-4 in a concentration-dependent manner.	Egtazic Acid	16-20	caspase 4	Homo sapiens	47-56
20020783-7	2009	The reduction of Ca(2+) entry by EGTA, but not its release from intracellular stores by BAPTA-AM, reduced the expression of NOS-3 and enhanced cell death in control and GCDCA-treated cells.	Egtazic Acid	33-37	nitric oxide synthase 3	Homo sapiens	124-129
19815560-8	2009	The Ca(2+) entry activated TRPC5 channels under buffering of internal Ca(2+) with EGTA but not with BAPTA.	Egtazic Acid	82-86	transient receptor potential cation channel subfamily C member 5	Homo sapiens	27-32
19850941-8	2009	Results further show that CaMKII can be activated by Ang II or H(2)O(2), even in the presence of the Ca(2+) chelator BAPTA-AM, in myocytes and in EGTA-Ca(2+)-free solutions in the presence of the calmodulin inhibitor W-7 in in vitro experiments.	Egtazic Acid	146-150	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	26-32
19850941-8	2009	Results further show that CaMKII can be activated by Ang II or H(2)O(2), even in the presence of the Ca(2+) chelator BAPTA-AM, in myocytes and in EGTA-Ca(2+)-free solutions in the presence of the calmodulin inhibitor W-7 in in vitro experiments.	Egtazic Acid	146-150	angiotensinogen	Rattus norvegicus	53-59
19919129-4	2009	ELISA, RT-PCR and Western blot assays demonstrated significant increases in the production and mRNA expression of IFN-gamma and protein kinase C-alpha (PKC-alpha) activation in activated PBMCs, which were abolished by EGTA, nifedipine and GO6976.	Egtazic Acid	218-222	interferon gamma	Homo sapiens	114-123
19919129-4	2009	ELISA, RT-PCR and Western blot assays demonstrated significant increases in the production and mRNA expression of IFN-gamma and protein kinase C-alpha (PKC-alpha) activation in activated PBMCs, which were abolished by EGTA, nifedipine and GO6976.	Egtazic Acid	218-222	protein kinase C alpha	Homo sapiens	152-161
19576918-7	2009	Additionally, blocking calcium entry with EGTA resulted in suppression of PDGF-induced Erk activation.	Egtazic Acid	42-46	mitogen-activated protein kinase 1	Homo sapiens	87-90
19304945-7	2009	oxLDL-induced monocyte chemoattractant protein-1 production was inhibited by pretreatment with calcium chelator EGTA or intracellular calcium trapping compound BAPTA, indicating that calcium ions mediate the effect of oxLDL on monocyte chemoattractant protein-1 induction.	Egtazic Acid	112-116	chemokine (C-C motif) ligand 2	Mus musculus	14-48
19577623-5	2009	Both GA-induced NO production and eNOS activation were attenuated by pretreatment of the cells with EGTA, an extracellular Ca(2+) chelator, and BAPTA-AM, an intracellular Ca(2+) chelator, but not by LY 294002, a PI3-kinase/Akt inhibitor, suggesting involvement of Ca(2+).	Egtazic Acid	100-104	nitric oxide synthase 3	Homo sapiens	34-38
19577623-5	2009	Both GA-induced NO production and eNOS activation were attenuated by pretreatment of the cells with EGTA, an extracellular Ca(2+) chelator, and BAPTA-AM, an intracellular Ca(2+) chelator, but not by LY 294002, a PI3-kinase/Akt inhibitor, suggesting involvement of Ca(2+).	Egtazic Acid	100-104	AKT serine/threonine kinase 1	Homo sapiens	223-226
19767829-7	2009	We examined the finding that the D288C actin protein does not polymerize under oxidizing conditions and forms protein aggregates when magnesium and EGTA are present.	Egtazic Acid	148-152	actin	Saccharomyces cerevisiae S288C	39-44
19381068-5	2009	AngII-induced collagen gel contraction was significantly blocked by extracellular calcium depletion by EGTA or by nifedipine which is an L-type calcium channel blocker.	Egtazic Acid	103-107	angiotensinogen	Rattus norvegicus	0-5
19381068-6	2009	In addition, AngII-induced calcium mobilization was also blocked by nifedipine and EGTA, whereas intracellular calcium store-depletion by thapsigargin was not effective.	Egtazic Acid	83-87	angiotensinogen	Rattus norvegicus	13-18
19486902-10	2009	Furthermore, intracellular Ca(2+) chelation by BAPTA-AM, extracellular Ca(2+) chelation by EGTA or blockade of L-type Ca(2+) channel with verapamil inhibited angiotensin II-induced JNK activation.	Egtazic Acid	91-95	angiotensinogen	Homo sapiens	158-172
19005168-4	2009	EGF also activated PKC, a process that was inhibited by AG1478 (an EGFR tyrosine kinase inhibitor) and ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA; an intracellular Ca(2+) chelator).	Egtazic Acid	103-167	epidermal growth factor	Gallus gallus	0-3
19164358-9	2009	PAF-stimulated LTB(4) release was abrogated by ethylene glycol tetraacetic acid suggesting a role for extracellular Ca(2+).	Egtazic Acid	47-79	PCNA clamp associated factor	Homo sapiens	0-3
19380828-10	2009	HMGB1 secretion was also induced by the calcium ionophore A23187 and inhibited by the Ca(2+) chelators BAPTA-AM and EGTA.	Egtazic Acid	116-120	high mobility group box 1	Homo sapiens	0-5
19402748-3	2009	We used EGTA or neuroactive PCB 95 to stabilize the full closed or open states of RyR1.	Egtazic Acid	8-12	ryanodine receptor 1	Homo sapiens	82-86
19005168-4	2009	EGF also activated PKC, a process that was inhibited by AG1478 (an EGFR tyrosine kinase inhibitor) and ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA; an intracellular Ca(2+) chelator).	Egtazic Acid	169-173	epidermal growth factor	Gallus gallus	0-3
19005168-5	2009	In addition, the degradation of NFKBIA and NFKB1 (p65) translocation was observed after EGF treatment, which was significantly blocked by pretreatment with AG1478, EGTA, H(7), or SN50 (NFKB1-specific inhibitor).	Egtazic Acid	164-168	nuclear factor kappa B subunit 1	Gallus gallus	185-190
19005168-5	2009	In addition, the degradation of NFKBIA and NFKB1 (p65) translocation was observed after EGF treatment, which was significantly blocked by pretreatment with AG1478, EGTA, H(7), or SN50 (NFKB1-specific inhibitor).	Egtazic Acid	164-168	NFKB inhibitor alpha	Gallus gallus	32-38
19005168-6	2009	Furthermore, we found that EGF-induced cell proliferation was significantly attenuated by AG1478, EGTA, H(7), and SN50, respectively.	Egtazic Acid	98-102	epidermal growth factor	Gallus gallus	27-30
19005168-5	2009	In addition, the degradation of NFKBIA and NFKB1 (p65) translocation was observed after EGF treatment, which was significantly blocked by pretreatment with AG1478, EGTA, H(7), or SN50 (NFKB1-specific inhibitor).	Egtazic Acid	164-168	nuclear factor kappa B subunit 1	Gallus gallus	43-48
19005168-5	2009	In addition, the degradation of NFKBIA and NFKB1 (p65) translocation was observed after EGF treatment, which was significantly blocked by pretreatment with AG1478, EGTA, H(7), or SN50 (NFKB1-specific inhibitor).	Egtazic Acid	164-168	synaptotagmin 1	Gallus gallus	50-53
19005168-5	2009	In addition, the degradation of NFKBIA and NFKB1 (p65) translocation was observed after EGF treatment, which was significantly blocked by pretreatment with AG1478, EGTA, H(7), or SN50 (NFKB1-specific inhibitor).	Egtazic Acid	164-168	epidermal growth factor	Gallus gallus	88-91
18836176-8	2009	Memantine, EGTA, or autocamtide-2-related inhibitory peptide (AIP) inhibited NFkappaB activation in the retina.	Egtazic Acid	11-15	nuclear factor kappa B subunit 1	Homo sapiens	77-85
19171135-6	2009	Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine.	Egtazic Acid	64-68	endothelin 1	Homo sapiens	0-12
19171135-6	2009	Endothelin-1-induced IL-6 production was markedly attenuated by EGTA and various Ca(2+) channel inhibitors such as 3,5-bis(trifluoromethyl)-1H-pyrazole derivative (BTP-2), 1-[beta-[3-(4-methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole hydrochloride (SKF96365), and nifedipine.	Egtazic Acid	64-68	interleukin 6	Homo sapiens	21-25
19138665-6	2009	Also, alpha-iso-cubebene-induced CXCL8 production was almost completely inhibited by the calcium chelator, EGTA, thus highlighting the role of calcium signaling in the process.	Egtazic Acid	107-111	C-X-C motif chemokine ligand 8	Homo sapiens	33-38
19135027-8	2009	In contrast, the addition of CaCl(2), EGTA or AlF(4)(-) strikingly modified the ETF without any effect on the LTF.	Egtazic Acid	38-42	TEA domain transcription factor 2	Homo sapiens	80-83
19056336-4	2009	Enzyme function was confirmed by the ability of each Ca(2+)-ATPase to rescue K616 growth on EGTA-containing agar and directly via in vitro ATP hydrolysis.	Egtazic Acid	92-96	calcium-transporting ATPase, endoplasmic reticulum-type	Solanum lycopersicum	53-66
19059380-7	2009	Inhibition of cell-cell adhesion using EGTA decreased Akt phosphorylation, which was reversed by calcium restoration.	Egtazic Acid	39-43	AKT serine/threonine kinase 1	Homo sapiens	54-57
18695008-4	2008	Using recordings of single Cx46 hemichannels, we found both forms of gating persist in solutions containing no added Mg(2+) and EGTA to chelate Ca(2+).	Egtazic Acid	128-132	gap junction protein alpha 3	Homo sapiens	27-31
19219302-5	2009	Pool size and exocytosis efficiency in p5-7 calyces were depressed by 0.2 mM EGTA to a greater extent than with 0.05 mM BAPTA, even though BAPTA is a 100-fold faster Ca2+ buffer.	Egtazic Acid	77-81	protein disulfide isomerase family A, member 6	Rattus norvegicus	39-43
18949369-12	2008	Treatment of cells with both H-89 and EGTA completely blocked the GnRHA-induced expression of Nur77, indicating that both calcium and cAMP/PKA play an important role in regulation of Nur77 expression by GnRHA.	Egtazic Acid	38-42	nuclear receptor subfamily 4, group A, member 1	Mus musculus	94-99
18949369-12	2008	Treatment of cells with both H-89 and EGTA completely blocked the GnRHA-induced expression of Nur77, indicating that both calcium and cAMP/PKA play an important role in regulation of Nur77 expression by GnRHA.	Egtazic Acid	38-42	nuclear receptor subfamily 4, group A, member 1	Mus musculus	183-188
18729383-4	2008	Unlike Myo1c (0IQ), the basal ATPase activity of Myo1c (1IQ) was &gt;10-fold higher in Ca (2+) vs EGTA +/- exogenous calmodulin, showing that regulation is by Ca (2+) binding to calmodulin on the first IQ domain.	Egtazic Acid	98-102	myosin IC	Homo sapiens	49-54
18948217-5	2009	Upon thrombin stimulation of platelets a major pool of cPLA(2)alpha was associated with the plasma membrane in an EGTA-resistant manner.	Egtazic Acid	114-118	coagulation factor II, thrombin	Homo sapiens	5-13
18948217-5	2009	Upon thrombin stimulation of platelets a major pool of cPLA(2)alpha was associated with the plasma membrane in an EGTA-resistant manner.	Egtazic Acid	114-118	phospholipase A2 group IVA	Homo sapiens	55-67
18948217-6	2009	EGTA-resistant membrane binding was abolished upon de-polymerisation of actin filaments by DNase I and furthermore, cPLA(2)alpha co-immunoprecipitated with actin upon thrombin stimulation of platelets.	Egtazic Acid	0-4	phospholipase A2 group IVA	Homo sapiens	116-128
18948217-6	2009	EGTA-resistant membrane binding was abolished upon de-polymerisation of actin filaments by DNase I and furthermore, cPLA(2)alpha co-immunoprecipitated with actin upon thrombin stimulation of platelets.	Egtazic Acid	0-4	coagulation factor II, thrombin	Homo sapiens	167-175
18842955-9	2008	Substitution of EGTA for calcium prevented BDNF effects.	Egtazic Acid	16-20	brain derived neurotrophic factor	Homo sapiens	43-47
18782625-4	2008	Two pools of annexin A6 are present in the sarcolemma fraction, one dependent on calcium and one that resists extraction by the calcium chelator EGTA.	Egtazic Acid	145-149	annexin A6 tv1	Sus scrofa	13-23
18044716-10	2008	Upon lowering pH in the presence of EGTA recombinant AnxA6-2 became less hydrophobic than AnxA6-1 as revealed by the Triton X-114 partition.	Egtazic Acid	36-40	annexin A6	Mus musculus	53-58
18510435-7	2008	When human adipose tissue-secreted adiponectin was treated with EGTA, there was a decrease in the HMW isoform by 61% (+/- 1.89%) and a corresponding increase in low molecular weight (LMW) and middle molecular weight (MMW) isoforms, compared to untreated samples.	Egtazic Acid	64-68	adiponectin, C1Q and collagen domain containing	Homo sapiens	35-46
18457657-2	2008	This study showed that stimulation with anti-CD3 mAb, PMA plus ionomycin, or an antigen increased the levels of GRP78 mRNA in primary T cells, which was inhibited by Ca(2+) chelators EGTA and BAPTA-AM and by an inhibitor of calcineurin FK506.	Egtazic Acid	183-187	heat shock protein 5	Mus musculus	112-117
18395756-7	2008	Ca(2+)/CaM further stimulated phosphorylation of 63- and 53-kD proteins by L-T3, which were inhibited both by EGTA (Ca(2+)-chelator) or KN62 (Ca(2+)/CaM kinase-II [CaMK-II] inhibitor), suggesting the role of CaMK-II.	Egtazic Acid	110-114	calmodulin 1	Rattus norvegicus	7-10
18522900-7	2008	The neurotoxic effect of NMDA on P19-N neurons was directly correlated with increased CaII entry, since the addition of EGTA or BAPTA-AM, significantly suppressed the NMDA-induced decrease of phospho-Akt and subsequent neuronal death.	Egtazic Acid	120-124	carbonic anhydrase 2	Mus musculus	86-90
18522900-7	2008	The neurotoxic effect of NMDA on P19-N neurons was directly correlated with increased CaII entry, since the addition of EGTA or BAPTA-AM, significantly suppressed the NMDA-induced decrease of phospho-Akt and subsequent neuronal death.	Egtazic Acid	120-124	thymoma viral proto-oncogene 1	Mus musculus	200-203
18395756-7	2008	Ca(2+)/CaM further stimulated phosphorylation of 63- and 53-kD proteins by L-T3, which were inhibited both by EGTA (Ca(2+)-chelator) or KN62 (Ca(2+)/CaM kinase-II [CaMK-II] inhibitor), suggesting the role of CaMK-II.	Egtazic Acid	110-114	calmodulin 1	Rattus norvegicus	149-152
18056367-2	2007	Chelating calcium with BAPTA-AM or EGTA potently inhibited HDAC- and CMV-mediated MICA/B expression.	Egtazic Acid	35-39	histone deacetylase 9	Homo sapiens	59-63
17654480-8	2008	Fas-induced recruitment of CaM into the DISC was inhibited by the Ca(2+) chelator, EGTA, and the CaM antagonist, trifluoperazine (TFP).	Egtazic Acid	83-87	calmodulin 1	Homo sapiens	27-30
17977944-9	2008	Moreover, hydrostatic pressure significantly reduced the loss of VE-cadherin-mediated adhesion in response to EGTA, cytochalasin D, and TFP in MyEnd cells as determined by laser tweezer trapping using VE-cadherin-coated microbeads.	Egtazic Acid	110-114	cadherin 5	Mus musculus	65-76
18953416-3	2008	TRAF4 is connected to assembled TJs in confluent epithelial cells, but accumulates in the cytoplasm and/or nucleus when TJs are open in isolated cells or EGTA-treated confluent cells.	Egtazic Acid	154-158	TNF receptor associated factor 4	Homo sapiens	0-5
18155948-4	2008	Among a number of inhibitors tested, the most efficient were 1,10-phenanthroline having a K(i) value of 0.12 mM and cysteine with K(i) value of 0.31 mM, while EGTA stimulated LAP activity.	Egtazic Acid	159-163	leucine aminopeptidase 3	Homo sapiens	175-178
18008137-3	2008	The H2O2 was insufficient to produce significant changes in the absence of extracellular calcium but addition of Ca2+ to H2O2-treated cells suspended in a free Ca2+/EGTA buffer resulted in a great increase in [Ca2+]i reflecting influx of Ca2+ across the cell membrane.	Egtazic Acid	165-169	carbonic anhydrase 2	Homo sapiens	113-116
18056367-2	2007	Chelating calcium with BAPTA-AM or EGTA potently inhibited HDAC- and CMV-mediated MICA/B expression.	Egtazic Acid	35-39	MHC class I polypeptide-related sequence A	Homo sapiens	82-86
17804410-7	2007	The SOX9-dependent reporter activity due to TRPV4 activation was abrogated by both EGTA and a calmodulin inhibitor, suggesting that the Ca2+/calmodulin signal is essential in this process.	Egtazic Acid	83-87	SRY (sex determining region Y)-box 9	Mus musculus	4-8
17927688-6	2007	Indeed, the rapid degradation of connexin50 (but not PKC delta) induced by rottlerin and FCCP was blocked by EGTA.	Egtazic Acid	109-113	gap junction protein alpha 8	Homo sapiens	33-43
17804410-7	2007	The SOX9-dependent reporter activity due to TRPV4 activation was abrogated by both EGTA and a calmodulin inhibitor, suggesting that the Ca2+/calmodulin signal is essential in this process.	Egtazic Acid	83-87	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	44-49
17670896-3	2007	Ca(2+)-dependent, homophilic VE-cadherin binding of endothelial cells, derived from human umbilical veins and grown as monolayers, was disrupted with EGTA, an antibody to the extracellular domain of VE-cadherin, or gene silencing of VE-cadherin with small interfering RNA.	Egtazic Acid	150-154	cadherin 5	Homo sapiens	29-40
17684040-4	2007	We demonstrated that the absence of external Ca(2+) and the presence of EGTA reduced the intracellular alkalinization and ERK1/2 phosphorylation induced by PAF, apparently via SOCE influx inhibition.	Egtazic Acid	72-76	mitogen-activated protein kinase 3	Bos taurus	122-128
17684040-4	2007	We demonstrated that the absence of external Ca(2+) and the presence of EGTA reduced the intracellular alkalinization and ERK1/2 phosphorylation induced by PAF, apparently via SOCE influx inhibition.	Egtazic Acid	72-76	PCNA-associated factor	Bos taurus	156-159
17670896-3	2007	Ca(2+)-dependent, homophilic VE-cadherin binding of endothelial cells, derived from human umbilical veins and grown as monolayers, was disrupted with EGTA, an antibody to the extracellular domain of VE-cadherin, or gene silencing of VE-cadherin with small interfering RNA.	Egtazic Acid	150-154	cadherin 5	Homo sapiens	199-210
17670896-3	2007	Ca(2+)-dependent, homophilic VE-cadherin binding of endothelial cells, derived from human umbilical veins and grown as monolayers, was disrupted with EGTA, an antibody to the extracellular domain of VE-cadherin, or gene silencing of VE-cadherin with small interfering RNA.	Egtazic Acid	150-154	cadherin 5	Homo sapiens	199-210
17403136-4	2007	Evoked SOD1 release was correlated with depolarization-dependent calcium influx and was virtually abolished by removal of extracellular calcium with EGTA or by pre-incubation of GH(3) cells with Botulinum toxin A that cleaves the SNARE protein SNAP-25.	Egtazic Acid	149-153	superoxide dismutase 1	Rattus norvegicus	7-11
17628500-9	2007	Addition of 1 mM EGTA during the incubation with NA reduced the AVP increase by half, indicating that both nNOS and iNOS activities are involved in the regulation.	Egtazic Acid	17-21	nitric oxide synthase 1, neuronal	Mus musculus	107-111
17628500-9	2007	Addition of 1 mM EGTA during the incubation with NA reduced the AVP increase by half, indicating that both nNOS and iNOS activities are involved in the regulation.	Egtazic Acid	17-21	nitric oxide synthase 2, inducible	Mus musculus	116-120
17120084-5	2007	Moreover, hormone-dependent activation of JNK 1/2 was dependent on calcium, since pretreatment of cells with BAPTA-AM or EGTA blocked PTH effects.	Egtazic Acid	121-125	mitogen-activated protein kinase 8	Rattus norvegicus	42-45
17533428-7	2007	ET-1 (in quiescent cells), PDGF-BB (in activated cells) and ATP (in both cells) all induced transient increases in [Ca(2+)](i) in the absence of extracellular Ca(2+) (with EGTA), indicating the involvement of Ca(2+) release from intracellular Ca(2+) stores.	Egtazic Acid	172-176	endothelin 1	Rattus norvegicus	0-4
17276043-5	2007	In the presence of Ca(2+), CaM adopts a conformation that favors interaction between hydrophobic pockets in CaM and phenothiazine, while in the presence of a Ca(2+)-chelating agent such as EGTA, the interaction between CaM and phenothiazine is disrupted, thus allowing for removal of the CaM-fusion protein from the surface under mild conditions.	Egtazic Acid	189-193	calmodulin 1	Homo sapiens	27-30
17276043-5	2007	In the presence of Ca(2+), CaM adopts a conformation that favors interaction between hydrophobic pockets in CaM and phenothiazine, while in the presence of a Ca(2+)-chelating agent such as EGTA, the interaction between CaM and phenothiazine is disrupted, thus allowing for removal of the CaM-fusion protein from the surface under mild conditions.	Egtazic Acid	189-193	calmodulin 1	Homo sapiens	108-111
17276043-5	2007	In the presence of Ca(2+), CaM adopts a conformation that favors interaction between hydrophobic pockets in CaM and phenothiazine, while in the presence of a Ca(2+)-chelating agent such as EGTA, the interaction between CaM and phenothiazine is disrupted, thus allowing for removal of the CaM-fusion protein from the surface under mild conditions.	Egtazic Acid	189-193	calmodulin 1	Homo sapiens	108-111
17276043-5	2007	In the presence of Ca(2+), CaM adopts a conformation that favors interaction between hydrophobic pockets in CaM and phenothiazine, while in the presence of a Ca(2+)-chelating agent such as EGTA, the interaction between CaM and phenothiazine is disrupted, thus allowing for removal of the CaM-fusion protein from the surface under mild conditions.	Egtazic Acid	189-193	calmodulin 1	Homo sapiens	108-111
17395158-5	2007	Furthermore, binding of SHP2 with Annexin II was regulated somewhat by EGF treatment and the extracellular Ca2+ chelator, EGTA.	Egtazic Acid	122-126	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	24-28
17395158-5	2007	Furthermore, binding of SHP2 with Annexin II was regulated somewhat by EGF treatment and the extracellular Ca2+ chelator, EGTA.	Egtazic Acid	122-126	annexin A2	Homo sapiens	34-44
17303079-5	2007	The Ca2+-chelating reagent EGTA blocked the cofilin dephosphorylation induced by both capsaicin and ionomycin, suggesting that the dephosphorylation was mediated by Ca2+ influx.	Egtazic Acid	27-31	cofilin 1	Homo sapiens	44-51
17332266-5	2007	EGTA and ruthenium red inhibited cell surface TRPV1 activity, but they did not prevent ER stress gene responses or cytotoxicity.	Egtazic Acid	0-4	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
17120084-5	2007	Moreover, hormone-dependent activation of JNK 1/2 was dependent on calcium, since pretreatment of cells with BAPTA-AM or EGTA blocked PTH effects.	Egtazic Acid	121-125	parathyroid hormone	Rattus norvegicus	134-137
17409452-5	2007	This increased aggregation seems to be dependent on E-cadherin because it was completely abrogated in the presence of function-blocking E-cadherin antibody or EGTA, a calcium-chelating agent.	Egtazic Acid	159-163	cadherin 1	Homo sapiens	52-62
17359489-11	2007	CONCLUSIONS: The CaR activators R-568 and gentamycin, both significantly delayed the recovery of p-Ca(2+) from acute EGTA-induced hypocalcaemia in TPTX rats.	Egtazic Acid	117-121	calcium-sensing receptor	Rattus norvegicus	17-20
17327279-4	2007	Functionally, the loss of TIMP3 exerted cell-type-specific effects, with Timp3(-/-) MEFs being more sensitive and Timp3(-/-) MECs more resistant to EGTA-induced cell detachment than the wild type.	Egtazic Acid	148-152	tissue inhibitor of metalloproteinase 3	Mus musculus	26-31
17546201-5	2007	In resting conditions (in the presence of EGTA or with no ionophore) AnxA6 was localized uniformly in the cytosol, whereas it translocated to vesicular structures beneath the plasma membrane within 5 min following stimulation of Jurkat T cells and rise of intracellular [Ca(2+)] at pH 7.4.	Egtazic Acid	42-46	annexin A6	Homo sapiens	69-74
17332522-11	2007	Finally, EGTA or vanadate reduced quercetin and cAMP-increased in StAR mRNA expression in MA-10 cells, while ICI 182,780 had no effect.	Egtazic Acid	9-13	steroidogenic acute regulatory protein	Mus musculus	66-70
17355198-6	2007	For VE-cadherin, a Z" of 0.52 was obtained between serum-free medium, which increased VE-cadherin, and EGTA, which diminished VE-cadherin at the plasma membrane.	Egtazic Acid	103-107	cadherin 5	Homo sapiens	4-15
17332522-8	2007	We found that EGTA inhibited quercetin-plus cAMP-stimulated progesterone secretion and StAR promoter activity.	Egtazic Acid	14-18	steroidogenic acute regulatory protein	Mus musculus	87-91
17365862-2	2007	Addition of thrombin to platelets in the presence of extracellular EGTA caused a rapid and transient release of Ca2+ from intracellular stores and rendered platelets unresponsive to a second addition of the same agonist.	Egtazic Acid	67-71	coagulation factor II, thrombin	Homo sapiens	12-20
17310095-4	2007	Here, whole-cell currents of the TRPM7 channel heterologously expressed in HEK293T cells were found to be augmented not only by perfusion of bath solution but also by osmotic swelling even under the conditions where exocytotic events can hardly take place in the cytosol dialyzed with ATP-free, Ca(2+)-free and EGTA-containing pipette solution.	Egtazic Acid	311-315	transient receptor potential cation channel subfamily M member 7	Homo sapiens	33-38
16956967-3	2007	Thus lowering the levels of cellular calcium with the chelators EGTA and BAPTA AM results in a downregulation of TRPC1-TRPC4 gene and protein expression.	Egtazic Acid	64-68	short transient receptor potential channel 1	Cavia porcellus	113-118
16956967-3	2007	Thus lowering the levels of cellular calcium with the chelators EGTA and BAPTA AM results in a downregulation of TRPC1-TRPC4 gene and protein expression.	Egtazic Acid	64-68	short transient receptor potential channel 4	Cavia porcellus	119-124
16887864-7	2007	DOC-induced NF-kappaB activation was significantly (P &lt; 0.05) inhibited by pre-treatment of cells with CAPE, EGCG, TMS, DPI, NaN3, EGTA, Ouabain and RuR.	Egtazic Acid	134-138	nuclear factor kappa B subunit 1	Homo sapiens	12-21
16386257-5	2006	Preincubation with EGTA (10mM) released ANXII from the cell membrane and inhibited the E(2)-mediated MMP-9 activity as did incubation of macrophages with anti-annexin IgG.	Egtazic Acid	19-23	annexin A2	Homo sapiens	40-45
16962685-6	2007	Application of EDTA, NTA and DTPA, and to a lesser extent EGTA, significantly enhanced PrP(Sc) signals in immunoblots.	Egtazic Acid	58-62	prion protein	Homo sapiens	87-90
16973698-8	2006	For 2 ms depolarizations evoking maximal responses, the EAAT5-mediated current carried between 2 and 8 times more charge as an average inhibitory GABA or glycine postsynaptic current received spontaneously from amacrine cells, with 10 mm or 0.5 mm intracellular EGTA, respectively.	Egtazic Acid	262-266	solute carrier family 1 (glutamate transporter), member 7	Mus musculus	56-61
16386257-5	2006	Preincubation with EGTA (10mM) released ANXII from the cell membrane and inhibited the E(2)-mediated MMP-9 activity as did incubation of macrophages with anti-annexin IgG.	Egtazic Acid	19-23	matrix metallopeptidase 9	Homo sapiens	101-106
16873546-7	2006	In vitro degradation of reduced GhCesA1 ZnBD is inhibited by proteosome inhibitor MG132 and also by E64 and EGTA, suggesting that proteolysis is initiated by cysteine protease activity rather than the proteosome.	Egtazic Acid	108-112	cellulose synthase A catalytic subunit 8 [UDP-forming]-like	Gossypium hirsutum	32-39
17042919-14	2006	Injection of IP3 or CaCl2 increased the hSERT currents by approximately 65% (P &lt; 0.05; n = 10 each) and the effect of IP3 was abolished by preinjection of EGTA.	Egtazic Acid	158-162	solute carrier family 6 member 4	Homo sapiens	40-45
16707556-9	2006	Stimulation with DB also induced a marked increase in the release of cholecystokinin from STC-1 cells, an effect also abrogated by prior exposure to EGTA or L-type VSCC blockers.	Egtazic Acid	149-153	stanniocalcin 1	Mus musculus	90-95
16951552-5	2006	Unlike the situation in guinea pig gastric myocytes, desensitization was not affected by varying [EGTA]i. Pretreatment with the PLC inhibitor (U73122) blocked the activation of ICCh, and desensitization of ICCh was attenuated in PLC beta1 knock-out mice.	Egtazic Acid	98-102	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	128-131
16859717-10	2006	Moreover, both MK801 (10 microM), an antagonist of NMDA receptor, and EGTA (100 mM, but neither 50 nor 150 mM), an extracellular Ca2+ chelator, not only effectively inhibited the ERK5 activation but also markedly abolished CIP-induced survival of the CA1 neurons.	Egtazic Acid	70-74	carbonic anhydrase 2	Rattus norvegicus	129-132
16859717-10	2006	Moreover, both MK801 (10 microM), an antagonist of NMDA receptor, and EGTA (100 mM, but neither 50 nor 150 mM), an extracellular Ca2+ chelator, not only effectively inhibited the ERK5 activation but also markedly abolished CIP-induced survival of the CA1 neurons.	Egtazic Acid	70-74	mitogen-activated protein kinase 7	Rattus norvegicus	179-183
16859717-10	2006	Moreover, both MK801 (10 microM), an antagonist of NMDA receptor, and EGTA (100 mM, but neither 50 nor 150 mM), an extracellular Ca2+ chelator, not only effectively inhibited the ERK5 activation but also markedly abolished CIP-induced survival of the CA1 neurons.	Egtazic Acid	70-74	carbonic anhydrase 1	Rattus norvegicus	251-254
16893971-4	2006	Although upon uncaging NP-EGTA, which is a caged Ca(2+) compound, WT-PKCalpha displayed rapid membrane translocations within &lt;250 ms, PKCalpha constructs with C2 domains mutated in their Ca(2+)-binding region lacked any Ca(2+)-dependent translocation.	Egtazic Acid	26-30	protein kinase C alpha	Homo sapiens	69-77
16806956-8	2006	Using Fe(III)-immobilized metal chromatography to determine the apparent phosphorylation status of the enzyme in vivo, we showed that soluble SS was largely dephosphorylated in fruits fed EGTA or staurosporine, compared to fruits fed water or sucrose.	Egtazic Acid	188-192	sucrose synthase	Solanum lycopersicum	142-144
16785030-8	2006	Both of these increases, as well as Mrp2 internalization, were completely blocked by EGTA.	Egtazic Acid	85-89	ATP binding cassette subfamily C member 2	Rattus norvegicus	36-40
16338016-3	2006	The efficiency of viral transduction was improved through a temporal disruption of tight-junctions with EGTA allowing for the expression of human erythropoietin at levels of up to 2g/L in milk.	Egtazic Acid	104-108	erythropoietin	Homo sapiens	146-160
16501031-5	2006	Both EGTA and clodronate also prevented the bisphosphonate-induced inhibition of Rap1A prenylation, an effect that was reversed by addition of Ca2+.	Egtazic Acid	5-9	RAS-related protein 1a	Mus musculus	81-86
16707565-6	2006	Furthermore, the PTH 1-84 secretory response to EGTA-induced acute and severe hypocalcemia was significantly inhibited by PTH 7-84.	Egtazic Acid	48-52	parathyroid hormone	Rattus norvegicus	17-25
16707565-6	2006	Furthermore, the PTH 1-84 secretory response to EGTA-induced acute and severe hypocalcemia was significantly inhibited by PTH 7-84.	Egtazic Acid	48-52	parathyroid hormone	Rattus norvegicus	17-20
16630563-3	2006	Calcium chelators EGTA and BAPTA reduced [Ca2+]i levels and protected CEM-C7-14 cells from Dex-evoked E4BP4 upregulation as well as apoptosis.	Egtazic Acid	18-22	nuclear factor, interleukin 3 regulated	Homo sapiens	102-107
16794864-8	2006	Depletion of Ca2+ by simultaneous treatment of the cells with BAPTA/AM (Ca2+ mobilization blocker) and EGTA (Ca2+ influx blocker) almost completely blocked agonist-induced GAR-3 internalization.	Egtazic Acid	103-107	Muscarinic acetylcholine receptor gar-3	Caenorhabditis elegans	172-177
16823889-5	2006	A pmr1 null mutant strain of P. pastoris exhibited growth defects in media with the addition of EGTA, but with supplementation of Ca2+ to a calcium-deficient media reversed the growth defects of the mutant strain.	Egtazic Acid	96-100	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	2-6
16328454-10	2006	Also, buffering the intracellular calcium concentration with a high concentration of EGTA abolished the m1 receptor-induced inhibition of Kir2.1-Kir2.3, implicating a role for calcium in these responses.	Egtazic Acid	85-89	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	138-144
16328454-10	2006	Also, buffering the intracellular calcium concentration with a high concentration of EGTA abolished the m1 receptor-induced inhibition of Kir2.1-Kir2.3, implicating a role for calcium in these responses.	Egtazic Acid	85-89	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	145-151
16373333-3	2006	This confluence-dependent expression of HOXA1 was abrogated by incubation of cells with EGTA to produce loss of intercellular contact and rescued by extracellular addition of Ca2+.	Egtazic Acid	88-92	homeobox A1	Homo sapiens	40-45
16373336-4	2006	We found that inactivation of Ca(v)2.1 Ca2+ currents increased exponentially with current amplitude with low intracellular concentrations of the slow buffer EGTA (0.5 mm), but not with high concentrations of the fast Ca2+ buffer BAPTA (10 mm).	Egtazic Acid	157-161	immunoglobulin lambda variable 3-1	Homo sapiens	30-38
16485066-9	2006	EGTA at 2 mmol (ionized Ca2+ 0 mmol) reduced the DNA synthesis of IGF I and II to 29% and 26%, respectively (P &lt; 0.05).	Egtazic Acid	0-4	insulin like growth factor 1	Homo sapiens	66-71
16368433-4	2006	We treated Apc+/+ (WT) littermate small intestine with EGTA, an inhibitor of E-cadherin, and with LPA, an RhoA activator; both induced effects on adhesion and kinase activity that mimicked the Min/+ phenotype.	Egtazic Acid	55-59	cadherin 1	Mus musculus	77-87
16299551-7	2006	3.--Thrombin-induced GF contraction was inhibited by 5 mM EGTA (an extracellular calcium chelator) and verapamil (an L-type calcium channel blocker).	Egtazic Acid	58-62	coagulation factor II, thrombin	Homo sapiens	4-12
16297670-6	2006	AphA was inhibited by several chelating agents, including EDTA, EGTA, 1,10-phenanthroline and dipicolinic acid, with EDTA being apparently the most powerful inhibitor.	Egtazic Acid	64-68	acid phosphatase/phosphotransferase	Escherichia coli str. K-12 substr. MG1655	0-4
16169899-4	2006	SP-A binding was inhibited by EGTA, indicating calcium dependence.	Egtazic Acid	30-34	surfactant protein A1	Homo sapiens	0-4
16257974-8	2005	Disruption of cadherin ligation by EGTA or prevention of cadherin ligation by maintenance of cells at subconfluent density blocked activation of Mirk.	Egtazic Acid	35-39	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	145-149
16483831-6	2006	Ca(2+) chelation with EGTA, inhibition of the c-Src-tyrosine kinase family with PP1 or protein kinase A (PKA) with Rp-cAMP, attenuated hormone activation of p38 MAPK.	Egtazic Acid	22-26	mitogen activated protein kinase 14	Rattus norvegicus	157-160
16893669-8	2006	Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP.	Egtazic Acid	51-55	mitogen-activated protein kinase 3	Homo sapiens	129-136
16893669-8	2006	Ca(2+)-free extracellular medium (containing 0.5mM EGTA) and the use of gadolinium (5 microM), which suppressed MSACI, prevented ERK 1/2 and p38 phosphorylation by ATP.	Egtazic Acid	51-55	mitogen-activated protein kinase 1	Homo sapiens	141-144
17077182-8	2006	Also, the TaIAA1 transcript levels increase in the presence of a divalent cation, Ca(2+), and this effect is reversed by the calcium-chelating agent, EGTA.	Egtazic Acid	150-154	auxin-responsive protein IAA13	Triticum aestivum	10-16
16343928-3	2005	Increase of intracellular Ca(2+) resulted in inducing IL-8 gene expression and protein secretion, and addition of EGTA or BAPTA/AM before Ca(2+) stimulation inhibited the induction of IL-8 production.	Egtazic Acid	114-118	C-X-C motif chemokine ligand 8	Homo sapiens	184-188
15985269-9	2005	The involvement of Ca2+-mediated mechanisms in vimentin phosphorylation was evident when specific channel blockers (verapamil and nifedipine) or chelating agents (EGTA and BAPTA) were added during pre-incubation and incubation of the testes with T3.	Egtazic Acid	163-167	vimentin	Rattus norvegicus	47-55
16140375-6	2005	By contrast, EGTA, failed to inhibit PLC activity when pre-loaded with Ca2+, but like BAPTA, inhibited both basal and light-induced PLC activity when introduced without Ca2+.	Egtazic Acid	13-17	Phospholipase C at 21C	Drosophila melanogaster	132-135
16212941-7	2005	The activation of tTGase by AA or MTX was significantly inhibited by EGTA.	Egtazic Acid	69-73	transglutaminase 2	Homo sapiens	18-24
16212941-8	2005	Moreover, EGTA prevented the prolonged increase of intracellular Ca(2+) and tTGase activation by lysophosphatidic acid, but had no effect on the initial Ca(2+) increase.	Egtazic Acid	10-14	transglutaminase 2	Homo sapiens	76-82
16047385-5	2005	The CGRP release by CCL2 and CXCL1 was significantly inhibited by EGTA, omega-conotoxin GVIA (an N-type calcium channel blocker), thapsigargin, and ryanodine.	Egtazic Acid	66-70	calcitonin-related polypeptide alpha	Rattus norvegicus	4-8
16176935-4	2005	ELISA sandwich binding assays showed that FKBP12 binding was dependent on the free Ca2+ and was lower at 1-10 microM free Ca2+ compared with 1 mM EGTA and 1 mM Ca2+, and this effect was enhanced by the inclusion of 1 mM ATP.	Egtazic Acid	146-150	FKBP prolyl isomerase 1A	Homo sapiens	42-48
16047385-5	2005	The CGRP release by CCL2 and CXCL1 was significantly inhibited by EGTA, omega-conotoxin GVIA (an N-type calcium channel blocker), thapsigargin, and ryanodine.	Egtazic Acid	66-70	C-C motif chemokine ligand 2	Rattus norvegicus	20-24
16047385-5	2005	The CGRP release by CCL2 and CXCL1 was significantly inhibited by EGTA, omega-conotoxin GVIA (an N-type calcium channel blocker), thapsigargin, and ryanodine.	Egtazic Acid	66-70	C-X-C motif chemokine ligand 1	Rattus norvegicus	29-34
15958383-10	2005	Unlike ICAM-1 binding, which required only one activating agent, alpha(L) beta2/ICAM-3 binding required both Mg/EGTA and an activating mAb.	Egtazic Acid	112-116	intercellular adhesion molecule 3	Homo sapiens	80-86
16191197-6	2005	MRP8/14 demonstrated a calcium-dependent adherence to plasma membranes and primary granules and could be removed by washing with EGTA in a high ionic strength buffer.	Egtazic Acid	129-133	S100 calcium binding protein A8	Homo sapiens	0-4
16128741-8	2005	The aggregation was dependent on E-cadherin, because the spheroids dispersed into isolated cells on incubation with EGTA or anti-E-cadherin antibody following pipetting.	Egtazic Acid	116-120	cadherin 1	Homo sapiens	33-43
16030010-10	2005	Substituting EGTA for CaCl2 in the reaction mixture reduced the formation of some of the phospho-TPS peptides drastically, indicating that Ca2+-dependent kinases are active in the presence of Ca2+-independent SnRKs.	Egtazic Acid	13-17	trehalose-6-phosphate synthase	Arabidopsis thaliana	97-100
16051304-4	2005	Ligand binding to LSECtin was inhibited by EGTA but not by mannan, suggesting that LSECtin unlike DC-SIGN/R does not recognize high-mannose glycans on viral GPs.	Egtazic Acid	43-47	C-type lectin domain family 4 member G	Homo sapiens	18-25
16051304-4	2005	Ligand binding to LSECtin was inhibited by EGTA but not by mannan, suggesting that LSECtin unlike DC-SIGN/R does not recognize high-mannose glycans on viral GPs.	Egtazic Acid	43-47	C-type lectin domain family 4 member G	Homo sapiens	83-90
16007273-4	2005	In the present study, we analyzed the effects of the Ca2+ chelator EGTA (1.75 mM) on the expression and distribution of desmin in C2C12 myoblasts grown in culture.	Egtazic Acid	67-71	desmin	Mus musculus	120-126
16007273-7	2005	Control C2C12 cells showed a dense network of desmin from the perinuclear region to the cell periphery, whereas EGTA-treated cells showed desmin aggregates in the cytoplasm.	Egtazic Acid	112-116	desmin	Mus musculus	138-144
16007273-8	2005	RT-PCR analysis revealed a down-regulation of desmin expression in EGTA-treated C2C12 cells compared to untreated cells.	Egtazic Acid	67-71	desmin	Mus musculus	46-52
15817475-9	2005	More inhibition of the L,D-MDP-induced apoptotic DNA ladders and caspase-3 activity in RK(13) cells was obtained with EGTA pretreatment (83%) than just EGTA + L,D-MDP (47%).	Egtazic Acid	118-122	caspase-3	Oryctolagus cuniculus	65-74
15826946-8	2005	In the presence of EGTA/Mg(2+), relaxation times for residues in the C-domain of TnC are very similar to values in the presence of Ca(2+), whereas the N-domain becomes more flexible.	Egtazic Acid	19-23	tenascin C	Homo sapiens	81-84
15656791-9	2005	We found that &gt; or =10 mM EGTA increased [3H]dantrolene binding to RyR2 by approximately 2-fold.	Egtazic Acid	29-33	ryanodine receptor 2	Homo sapiens	70-74
16077198-7	2005	Although EDTA (2 mM) and to a lesser degree EGTA (5 mM) were individually cytotoxic, they exerted protective effect at 6 and partially at 12 hour of combined TNF-alpha and CHX treatment.	Egtazic Acid	44-48	tumor necrosis factor	Homo sapiens	158-167
15613495-4	2005	Although depletion of intra- or extracellular Ca(2+) pool using thapsigargin (TG) or EGTA, respectively, showed little effect, a TG-EGTA mixture significantly inhibited stretch-induced IKK activation and IL-6 secretion.	Egtazic Acid	132-136	interleukin 6	Homo sapiens	204-208
15728249-10	2005	We also show that Bet3 acts after COPII but before Rab1, alpha-SNAP and the EGTA-sensitive stage during ER-Golgi transport.	Egtazic Acid	76-80	trafficking protein particle complex subunit 3	Homo sapiens	18-22
15623527-11	2005	Consistent with this, OAG induced [Ca2+]i increase in the apical, but not basal, region of TRPC3-MDCK cells that was blocked by EGTA addition to the apical medium.	Egtazic Acid	128-132	transient receptor potential cation channel subfamily C member 3	Canis lupus familiaris	91-96
15790923-9	2005	The mRNA levels of VEGF increased by 6.3-fold on treatment with EGTA and by 4.7-fold in the low-calcium medium at 6 hours.	Egtazic Acid	64-68	vascular endothelial growth factor A	Homo sapiens	19-23
15840937-6	2005	Zea mays roots treated with CaCl(2), MgCl(2), PEG, EGTA, and ABA for 24 h, the ZmPP2C expression increased only by CaCl(2) treatment.	Egtazic Acid	51-55	Probable protein phosphatase 2C 10	Zea mays	79-85
15582581-5	2005	Over the same concentration range of the nucleotide that was effective for IL-6 synthesis, ATP caused an increase in the intracellular Ca(2+) concentration ([Ca(2+)](i)), which increase was inhibited by pretreatment with suramin, a P2Y receptor antagonist, or 2-aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-trisphosphate receptor blocker, but not by the extracellular Ca(2+)-chelating agent EGTA.	Egtazic Acid	400-404	interleukin 6	Homo sapiens	75-79
15670846-2	2005	Knock down of pmr-1 as well as overexpression of truncated Caenorhabditis elegans PMR1, which mimics dominant mutations observed in human Hailey-Hailey disease, renders the worm highly sensitive to EGTA and Mn2+.	Egtazic Acid	198-202	Calcium-transporting ATPase	Caenorhabditis elegans	14-19
15670846-2	2005	Knock down of pmr-1 as well as overexpression of truncated Caenorhabditis elegans PMR1, which mimics dominant mutations observed in human Hailey-Hailey disease, renders the worm highly sensitive to EGTA and Mn2+.	Egtazic Acid	198-202	Calcium-transporting ATPase	Caenorhabditis elegans	82-86
15702350-9	2005	Intracellular EGTA abolished the transient increase by ET-1 and partially inhibited the subsequent decrease in the currents.	Egtazic Acid	14-18	endothelin 1	Homo sapiens	55-59
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Egtazic Acid	106-110	calmodulin 2	Mus musculus	51-61
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Egtazic Acid	106-110	TNFAIP3 interacting protein 1	Mus musculus	169-172
15632291-6	2005	When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling.	Egtazic Acid	106-110	calmodulin 2	Mus musculus	177-187
15389553-7	2005	Although both SMF1- and SMF2-disrupted cells were very sensitive to EGTA, overexpression of BSD2 had little or no effect on sensitivity to EGTA.	Egtazic Acid	68-72	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	14-18
15389538-9	2005	However, when Ca2+ was depleted from cocultures using EGTA, a Ca2+ chelating agent, IQGAP1 lost its affinity for Cdc42 and became tightly associated with beta-catenin, destabilizing cadherin-mediated AJs between Sertoli and germ cells.	Egtazic Acid	54-58	IQ motif containing GTPase activating protein 1	Homo sapiens	84-90
15389553-7	2005	Although both SMF1- and SMF2-disrupted cells were very sensitive to EGTA, overexpression of BSD2 had little or no effect on sensitivity to EGTA.	Egtazic Acid	68-72	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	24-28
15389538-9	2005	However, when Ca2+ was depleted from cocultures using EGTA, a Ca2+ chelating agent, IQGAP1 lost its affinity for Cdc42 and became tightly associated with beta-catenin, destabilizing cadherin-mediated AJs between Sertoli and germ cells.	Egtazic Acid	54-58	cell division cycle 42	Homo sapiens	113-118
15389538-9	2005	However, when Ca2+ was depleted from cocultures using EGTA, a Ca2+ chelating agent, IQGAP1 lost its affinity for Cdc42 and became tightly associated with beta-catenin, destabilizing cadherin-mediated AJs between Sertoli and germ cells.	Egtazic Acid	54-58	catenin beta 1	Homo sapiens	154-166
15654884-7	2005	When Gd(3+) was applied at the trans side, EGTA was present at the cis side to prevent the binding of Gd(+3) to the cytoplasmic calcium binding regulatory sites of the RyR1 if Gd(3+) accidentally passed through the channel.	Egtazic Acid	43-47	ryanodine receptor 1	Oryctolagus cuniculus	168-172
15550032-7	2004	Furthermore, EGTA or calpeptin inhibited PECAM-1 cleavage.	Egtazic Acid	13-17	platelet and endothelial cell adhesion molecule 1	Homo sapiens	41-48
15896915-2	2005	We found that Pb2+ reduced the amplitudes of INa in a concentration-dependent manner, and the effect could be washed out by extracellular application of 3 mM EGTA.	Egtazic Acid	158-162	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	45-48
15530891-12	2004	The Ca2+ chelator ethylene glycol bis-(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA; 5 mM) added in standard artificial cerebrospinal fluid (ACSF) containing 0.1 mM caffeine fully blocked the oscillations.	Egtazic Acid	90-94	carbonic anhydrase 2	Rattus norvegicus	4-7
15319455-5	2004	On the other hand, cyclosporin A (a calcineurin-NFAT inhibitor) or EGTA (a calcium chelator) significantly blocked the depolarization-induced GHRH gene transcription.	Egtazic Acid	67-71	growth hormone releasing hormone	Rattus norvegicus	142-146
15254339-8	2004	The pretreatment of cells with BAPTA-AM and EGTA suppressed the cadmium-induced cell injury, including growth arrest, mitochondrial activity impairment, and necrosis, and it also recovered the cadmium-altered JNK and p38 MAPK activity.	Egtazic Acid	44-48	mitogen-activated protein kinase 8	Mus musculus	209-212
15368237-7	2004	Simulating the changes in calcium and phosphate concentration occasioned by the composites through exposing cells to EGTA and phosphate gives rise to the same effects of reducing proliferation, ALP activity, and mineralization.	Egtazic Acid	117-121	PDZ and LIM domain 3	Rattus norvegicus	194-197
15623158-8	2004	If [Ca2+]cyt increase is blocked with EGTA, exogenous CaM-induced stomatal closure is inhibited.	Egtazic Acid	38-42	calmodulin 1	Homo sapiens	54-57
15254339-8	2004	The pretreatment of cells with BAPTA-AM and EGTA suppressed the cadmium-induced cell injury, including growth arrest, mitochondrial activity impairment, and necrosis, and it also recovered the cadmium-altered JNK and p38 MAPK activity.	Egtazic Acid	44-48	mitogen-activated protein kinase 14	Mus musculus	217-220
15218074-3	2004	We tested the alternative hypothesis that PMA-induced mucin secretion is, in fact, a Ca2+-dependent process under the conditions of low bulk Ca2+, one that is permitted in the typical SLO-permeabilized cell model by the slow binding kinetics of EGTA.	Egtazic Acid	245-249	solute carrier family 13 member 2	Rattus norvegicus	54-59
15212760-4	2004	LPA but not S1P induces calcium flux response in Th1 and Th2 cells, which is due to the influx of extracellular calcium and is mediated by receptor activation, since EGTA and suramin (SUR) completely abrogate LPA-induced the release of calcium.	Egtazic Acid	166-170	negative elongation factor complex member C/D	Homo sapiens	49-52
15218074-2	2004	Previous studies demonstrated that mucin secretion from SLO-permeabilized, EGTA-buffered SPOC1 cells was stimulated by PMA at low Ca2+ levels (&lt; 0.1 microm), consistent with the notion that regulated exocytosis may occur by Ca2+-independent pathways.	Egtazic Acid	75-79	solute carrier family 13 member 2	Rattus norvegicus	35-40
15218074-4	2004	Both IP3 and elevated bulk Ca2+ activated mucin secretion in SPOC1 cells buffered by EGTA, suggesting that IP3 generates a local Ca2+ gradient in the vicinity of the secretory granules to the degree necessary to trigger exocytosis.	Egtazic Acid	85-89	solute carrier family 13 member 2	Rattus norvegicus	42-47
15166245-9	2004	HCV-pp transmission via L-SIGN or DC-SIGN is inhibited by characteristic inhibitors such as the calcium chelator EGTA and monoclonal antibodies directed against lectin carbohydrate recognition domains of both lectins.	Egtazic Acid	113-117	C-type lectin domain family 4 member M	Homo sapiens	24-30
15313016-3	2004	Chelation of calcium with EGTA after the onset of aggregation precluded subsequent destabilization of the aggregates in TRAP-stimulated platelets, whereas disaggregation was not observed in the platelets stimulated with thrombin.	Egtazic Acid	26-30	TRAP	Homo sapiens	120-124
15313016-7	2004	Two proteins of relative mobilities 67 and 75 kD were found to be significantly dephosphorylated on tyrosine in calcium-pretreated platelets as compared to the EGTA-treated platelets following continued stimulation with either TRAP or thrombin for 15 min.	Egtazic Acid	160-164	coagulation factor II, thrombin	Homo sapiens	235-243
15289936-8	2004	Salt and chelators of divalent cations such as EDTA and EGTA disrupted the TFF1- MUC5AC interaction and increased the degradation of MUC5AC, whereas calcium increased the amount of TFF1 bound to MUC5AC.	Egtazic Acid	56-60	trefoil factor 1	Homo sapiens	75-79
15289936-8	2004	Salt and chelators of divalent cations such as EDTA and EGTA disrupted the TFF1- MUC5AC interaction and increased the degradation of MUC5AC, whereas calcium increased the amount of TFF1 bound to MUC5AC.	Egtazic Acid	56-60	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	81-87
15289936-8	2004	Salt and chelators of divalent cations such as EDTA and EGTA disrupted the TFF1- MUC5AC interaction and increased the degradation of MUC5AC, whereas calcium increased the amount of TFF1 bound to MUC5AC.	Egtazic Acid	56-60	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	133-139
15289936-8	2004	Salt and chelators of divalent cations such as EDTA and EGTA disrupted the TFF1- MUC5AC interaction and increased the degradation of MUC5AC, whereas calcium increased the amount of TFF1 bound to MUC5AC.	Egtazic Acid	56-60	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	133-139
15350253-13	2004	Maintaining the superfused cells in medium containing 5 mM EGTA had no obvious effect on basal GnRH release but blocked the effect of db-cAMP to increase GnRH release.	Egtazic Acid	59-63	gonadotropin releasing hormone 1	Homo sapiens	154-158
15184369-3	2004	Whole cell recordings from non-transfected HEK cells and cells expressing human TRPV6 revealed the presence of a basal inward current in both types of cells when the internal solution contained 0.1 mm EGTA and 100 nm [Ca(2+)](i) or if the cytosolic Ca(2+) buffering remained undisturbed in perforated patch-clamp experiments.	Egtazic Acid	201-205	transient receptor potential cation channel subfamily V member 6	Homo sapiens	80-85
15184369-6	2004	In contrast, dialyzing 0.5 mm EGTA into TRPV6-expressing cells readily activated Ca(2+) inward currents, which were undetectable in non-transfected cells.	Egtazic Acid	30-34	transient receptor potential cation channel subfamily V member 6	Homo sapiens	40-45
32585778-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 muM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca2+-free/EGTA (1 mM) bath solution, than IDHPG, suggesting that these responses are, in the main part, mediated by distinct processes.	Egtazic Acid	239-243	carbonic anhydrase 2	Rattus norvegicus	18-21
15174074-6	2004	The subcellular localization of PMP22 in cultured brain endothelia was confirmed by internalization with ZO-1 after EGTA-induced disruption of cell junctions.	Egtazic Acid	116-120	peripheral myelin protein 22	Rattus norvegicus	32-37
15174074-6	2004	The subcellular localization of PMP22 in cultured brain endothelia was confirmed by internalization with ZO-1 after EGTA-induced disruption of cell junctions.	Egtazic Acid	116-120	tight junction protein 1	Rattus norvegicus	105-109
15139009-3	2004	Hypoosmolarity (2 h) increases total PTN by about 2-fold in 2 h. The hypoosmotic PTN is significantly inhibited by the NMDA receptor antagonist MK-801, the nitric oxide synthase (NOS) inhibitor L-NMMA, the extracellular Ca2+ chelator EGTA and the calmodulin antagonist W13, suggesting the involvement of NMDA receptor activation, influx of extracellular Ca2+ and Ca2+/calmodulin-dependent NO synthesis.	Egtazic Acid	234-238	pleiotrophin	Rattus norvegicus	81-84
15080792-6	2004	The binding of biotinylated CaM to ErbB2 depends strictly on the presence of Ca2+, since it was prevented by the presence of EGTA.	Egtazic Acid	125-129	calmodulin 3	Homo sapiens	28-31
15080792-6	2004	The binding of biotinylated CaM to ErbB2 depends strictly on the presence of Ca2+, since it was prevented by the presence of EGTA.	Egtazic Acid	125-129	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-40
15126055-7	2004	When extracellular Ca(2+) was buffered with EGTA, ACh mobilized intracellular calcium stores and the [Ca(2+)](i) increase was reduced by 2-aminoethoxydiphenyl borate but not by dantrolene, indicating the involvement of inositol triphosphate receptors (InsP(3)R).	Egtazic Acid	44-48	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	252-261
15142951-7	2004	Collagen or CRP-stimulated 12-H(P)ETE generation was inhibited by staurosporine, PP2, wortmannin, BAPTA/AM, EGTA, and L-655238, implicating src-tyrosine kinases, PI3-kinase, Ca2+ mobilization, and p12-LOX translocation.	Egtazic Acid	108-112	C-reactive protein	Homo sapiens	12-15
15111012-4	2004	The DHPG-induced [Ca2+]i rise was much more sensitive to manipulations of Ca2+ homeostasis, such as using the Ca2+ store depleting agent, cyclopiazonic acid (50-100 microM), the fast Ca2+ buffer, BAPTA (intracellular; 20-40 mM) and Ca(2+)-free/EGTA (1 mM) bath solution, than I(DHPG), suggesting that these responses are, in the main part, mediated by distinct processes.	Egtazic Acid	244-248	carbonic anhydrase 2	Rattus norvegicus	18-21
15129169-2	2004	Pretreatment with Ca2+ chelators (EGTA or BAPTA-AM) attenuated the butyrate-triggered accumulation of TH and ppEnk mRNA indicating that Ca2+ plays a role in butyrate-induced regulation of neuronal genes.	Egtazic Acid	34-38	carbonic anhydrase 2	Rattus norvegicus	18-21
15161963-6	2004	This process is blocked by EGTA treatment, implying that AnnAt1 functions in stress response are tightly associated with Ca2+.	Egtazic Acid	27-31	annexin 1	Arabidopsis thaliana	57-63
15129169-2	2004	Pretreatment with Ca2+ chelators (EGTA or BAPTA-AM) attenuated the butyrate-triggered accumulation of TH and ppEnk mRNA indicating that Ca2+ plays a role in butyrate-induced regulation of neuronal genes.	Egtazic Acid	34-38	carbonic anhydrase 2	Rattus norvegicus	136-139
14522820-9	2004	This conclusion was confirmed at the level of single RyRs in planar lipid bilayers: using flash photolysis of the calcium cage NP-EGTA to generate two sequential calcium stimuli, we showed that RyR activation in response to the second stimulus was four times higher than that in response to the first stimulus.	Egtazic Acid	130-134	ryanodine receptor 2	Rattus norvegicus	53-56
14755000-6	2004	In comparison to results we previously obtained with exogenous Ca(2+) buffers, PV closely mimicked the actions of the slow buffer EGTA, whereas CR showed important differences from the fast buffer BAPTA.	Egtazic Acid	130-134	parvalbumin S homeolog	Xenopus laevis	79-81
15020222-5	2004	(d) PDBu also induced rapid proteolysis of two endogenous substrates of calpains, i.e., tau and microtubule-associated protein-2 (MAP-2) and the proteolysis was blocked by EGTA and calpain inhibitors.	Egtazic Acid	172-176	microtubule associated protein 2	Homo sapiens	130-135
14657188-7	2004	Xenopus oocytes injected with SK2 in vitro transcribed RNA, under conditions where only outward K+ currents could be recorded, expressed an outward current that was sensitive to EGTA, dequalinium chloride, and apamin.	Egtazic Acid	178-182	sphingosine kinase 2	Homo sapiens	30-33
14676843-5	2004	Preincubation with EGTA suppressed p38 activation, while calcium ionophore induced p38 activity.	Egtazic Acid	19-23	mitogen-activated protein kinase 14	Homo sapiens	35-38
17903964-7	2004	Further experiments showed that inclusion of calcium chelator egtazic acid in measurement of mitochondrial respiration could completely restore the efficiency of mitochondrial respiration in injured brains of nontransgenic mice and Gpx1-/- mice, suggesting that the observed mitochondrial dysfunction is a direct result of increase in mitochondrion-associated calcium, which is secondary to the increased oxidative stress.	Egtazic Acid	62-74	glutathione peroxidase 1	Mus musculus	232-236
15094063-3	2004	TG-stimulated ERK1/ERK2 phosphorylation was also diminished in buffer containing EGTA, a calcium chelator, further suggesting the implication of calcium influx in MAPK activation in these cells.	Egtazic Acid	81-85	mitogen-activated protein kinase 3	Homo sapiens	14-18
15094063-3	2004	TG-stimulated ERK1/ERK2 phosphorylation was also diminished in buffer containing EGTA, a calcium chelator, further suggesting the implication of calcium influx in MAPK activation in these cells.	Egtazic Acid	81-85	mitogen-activated protein kinase 1	Homo sapiens	19-23
15025937-4	2004	BAPTA-AM and EGTA, chelators of intracellular and extracellular Ca(2+), respectively, inhibited H(2)O(2)-stimulated ERK1/2, p38 MAPK, and PKB phosphorylation.	Egtazic Acid	13-17	mitogen-activated protein kinase 3	Homo sapiens	116-122
15025937-4	2004	BAPTA-AM and EGTA, chelators of intracellular and extracellular Ca(2+), respectively, inhibited H(2)O(2)-stimulated ERK1/2, p38 MAPK, and PKB phosphorylation.	Egtazic Acid	13-17	mitogen-activated protein kinase 1	Homo sapiens	124-127
15025937-4	2004	BAPTA-AM and EGTA, chelators of intracellular and extracellular Ca(2+), respectively, inhibited H(2)O(2)-stimulated ERK1/2, p38 MAPK, and PKB phosphorylation.	Egtazic Acid	13-17	protein tyrosine kinase 2 beta	Homo sapiens	138-141
14981072-10	2004	In Ca2+-free (2 mmol/L EGTA) Hank"s solution, ET-1 caused 15% cell contraction, with no increase in [Ca2+]i, and translocation of epsilon-PKC that were inhibited by epsilon-PKC V1-2 inhibitory peptide.	Egtazic Acid	23-27	endothelin 1	Homo sapiens	46-50
14978732-3	2004	We report that: (1) removal of calcium from the culture medium of newly confluent Caco-2/15 cells (30 min, 4 mM EGTA) results in the disruption of both adherens and tight junctions and clearly decreases Akt phosphorylation while increasing MEK and ERK activities.	Egtazic Acid	112-116	AKT serine/threonine kinase 1	Homo sapiens	203-206
14724272-9	2004	With intracellular Ca2+ buffered by EGTA in the recording pipette, vitronectin-activated K+ current was abolished.	Egtazic Acid	36-40	vitronectin	Bos taurus	67-78
15104236-5	2004	Recruitment of both 5-LO and cPLA2 to the membranes was suppressed by EGTA.	Egtazic Acid	70-74	phospholipase A2 group IVA	Rattus norvegicus	29-34
14966371-0	2004	Thapsigargin and EGTA inhibit endothelin-1-induced glucose transport.	Egtazic Acid	17-21	endothelin 1	Homo sapiens	30-42
14966371-3	2004	Among a variety of Ca(2+)-related agents tested, EGTA and thapsigargin were found to suppress both the glucose uptake and intracellular Ca(2+) mobilization induced by ET-1, as determined by Fura-2 analysis.	Egtazic Acid	49-53	endothelin 1	Homo sapiens	167-171
14757168-10	2004	Concomitantly with MPT, gold(I) compounds determined the release of cytochrome c that, however, occurred also in the presence of cyclosporin A and, partially, of EGTA, indicating its independence of MPT.	Egtazic Acid	162-166	cytochrome c, somatic	Homo sapiens	68-80
14686920-7	2004	Treatment of A23187-stimulated cells with EGTA or BAPTA-AM demonstrated that a substantial pool of cPLA2-alpha remained associated with membrane fractions in a calcium-independent manner.	Egtazic Acid	42-46	phospholipase A2 group IVA	Homo sapiens	99-110
14719136-7	2004	Regucalcin (10(-9) and 10(-8) M) significantly inhibited protein phosphatase activity toward three phosphoaminoacids in the presence of ethylene glycol bis (2-aminoethlether) N,N,N",N"-tetraacetic acid (EGTA; 1 mM), without Ca2+ addition.	Egtazic Acid	203-207	regucalcin	Rattus norvegicus	0-10
14576159-7	2004	Alteration of cell polarity after cholesterol depletion or loosening of the cell-cell junctions after EGTA treatment rapidly impaired membrane targeting of PrPc.	Egtazic Acid	102-106	prion protein	Homo sapiens	156-160
12968021-5	2003	The current mediated by P2X7R was isolated by infusing the cells with high [EGTA].	Egtazic Acid	76-80	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	24-29
14723709-3	2004	The pmr1 knockout (Deltapmr1) cells exhibited hypersensitivity to EGTA.	Egtazic Acid	66-70	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	4-8
15262326-5	2004	The activity of CaMK IV in neuronal nuclei was determined by 33P-incorporation into syntide 2 in the presence or absence of either 1 mM EGTA or 0.8 mM CaCl2 and 1 mM calmodulin.	Egtazic Acid	136-140	calcium/calmodulin dependent protein kinase IV	Homo sapiens	16-23
14690445-2	2003	We report that uninfected Sf9 cells readily undergo apoptosis and show increased phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) in the presence of agents such as UVB light, etoposide, high concentrations of cycloheximide, and EGTA.	Egtazic Acid	262-266	eukaryotic translation initiation factor 2A	Homo sapiens	153-162
14522959-10	2003	Akt activation in mutant striatal cells is Ca(2+)-dependent, because treatment with EGTA reduces levels of Ser(P)473-Akt.	Egtazic Acid	84-88	thymoma viral proto-oncogene 1	Mus musculus	0-3
14522959-10	2003	Akt activation in mutant striatal cells is Ca(2+)-dependent, because treatment with EGTA reduces levels of Ser(P)473-Akt.	Egtazic Acid	84-88	thymoma viral proto-oncogene 1	Mus musculus	117-120
14709154-11	2004	Incubation in Ca2+-free buffer supplemented with 0.1 mM EGTA blocked the MIN6 cells" secretory response to 1 and 10 nM ACTH(1-24).	Egtazic Acid	56-60	pro-opiomelanocortin-alpha	Mus musculus	119-123
14561757-8	2003	Steady-state analysis indicated that the Delta45 supported NO synthesis in the absence of CaM at 60% of the rate in its presence, consistent with our prior result that CaM-bound Delta45 retained 60% of its activity in the presence of 10 mm EGTA.	Egtazic Acid	240-244	calmodulin 1	Homo sapiens	168-171
12882766-9	2003	Chelation of extracellular Ca2+ by EGTA had marginal effects on DPV-induced phosphorylation of Src and cortactin; actin stress fibers formation, however, affected EC barrier function.	Egtazic Acid	35-39	carbonic anhydrase 2	Bos taurus	27-30
14638856-6	2003	Low intensity photolysis of NP-EGTA produced a slow [Ca2+] ramp and revealed that translocation of hippocalcin-EYFP initiated at around 180 nM and was half maximal at 290 nM.	Egtazic Acid	31-35	hippocalcin	Homo sapiens	99-110
14534265-4	2003	The calcium chelator EGTA was used to lower [Ca2+]o in the hippocampus of urethane anesthetized rats.	Egtazic Acid	21-25	carbonic anhydrase 2	Rattus norvegicus	45-48
14665741-6	2003	In Western blot analysis with anti-phosphorylated MAPK antibodies, ET-1 (3 nM) enhanced activities of both ERK1/2 and p38 MAPK in aortic muscle strips, which were not attenuated by the treatment with 4 mM EGTA.	Egtazic Acid	205-209	endothelin 1	Rattus norvegicus	67-71
14665741-6	2003	In Western blot analysis with anti-phosphorylated MAPK antibodies, ET-1 (3 nM) enhanced activities of both ERK1/2 and p38 MAPK in aortic muscle strips, which were not attenuated by the treatment with 4 mM EGTA.	Egtazic Acid	205-209	mitogen activated protein kinase 3	Rattus norvegicus	107-113
12847111-7	2003	Moreover, LPA-induced increases in Ca2+ transients and/or iNOS expression in highly purified rat liver nuclei were prevented by pertussis toxin, phosphoinositide 3-kinase/Akt inhibitor wortmannin and Ca2+ chelator and channel blockers EGTA and SK&amp;F96365, respectively.	Egtazic Acid	235-239	nitric oxide synthase 2	Rattus norvegicus	58-62
14554103-2	2003	In particular, EGTA, ADP, and cyclosporin A (potent mitochondrial permeability transition antagonists) affected mainly Cd2+-induced changes in resting state respiration, eliminating its stimulation in KCl medium, while dithiothreitol (DTT, a dithiol reductant) produced its effect both on Cd2+ activation of the basal respiration and Cd2+ depression of uncoupler-stimulated respiration, evoking its restoration.	Egtazic Acid	15-19	Cd2 molecule	Rattus norvegicus	119-122
14554103-2	2003	In particular, EGTA, ADP, and cyclosporin A (potent mitochondrial permeability transition antagonists) affected mainly Cd2+-induced changes in resting state respiration, eliminating its stimulation in KCl medium, while dithiothreitol (DTT, a dithiol reductant) produced its effect both on Cd2+ activation of the basal respiration and Cd2+ depression of uncoupler-stimulated respiration, evoking its restoration.	Egtazic Acid	15-19	Cd2 molecule	Rattus norvegicus	289-292
14554103-2	2003	In particular, EGTA, ADP, and cyclosporin A (potent mitochondrial permeability transition antagonists) affected mainly Cd2+-induced changes in resting state respiration, eliminating its stimulation in KCl medium, while dithiothreitol (DTT, a dithiol reductant) produced its effect both on Cd2+ activation of the basal respiration and Cd2+ depression of uncoupler-stimulated respiration, evoking its restoration.	Egtazic Acid	15-19	Cd2 molecule	Rattus norvegicus	289-292
12759218-6	2003	The effect was also abrogated by chelating intracellular calcium with BAPTA-AM or TMB-8 by depleting intracellular calcium stores with a 30-min pretreatment with EGTA and by pretreatment with herbimycin A and PP1, two c-Src tyrosine kinase inhibitors.	Egtazic Acid	162-166	neuropeptide Y receptor Y4	Rattus norvegicus	209-212
12890758-6	2003	Consistent with an involvement of PLC-gamma1 in E-lam formation, intracellular free calcium (Ca2+) was elevated during the formation of E-lams and conversely, E-lam formation was blocked by intracellular Ca2+ chelation with BAPTA/AM, but not by extracellular reduction of Ca2+ by EGTA.	Egtazic Acid	280-284	phospholipase C gamma 1	Homo sapiens	34-44
12759218-6	2003	The effect was also abrogated by chelating intracellular calcium with BAPTA-AM or TMB-8 by depleting intracellular calcium stores with a 30-min pretreatment with EGTA and by pretreatment with herbimycin A and PP1, two c-Src tyrosine kinase inhibitors.	Egtazic Acid	162-166	C-terminal Src kinase	Rattus norvegicus	218-239
14586134-4	2003	In contrast, PMNs suspended in serum containing sufficient amounts of hemopexin to inhibit adhesion showed marked adherence, which was inhibited by EGTA.	Egtazic Acid	148-152	hemopexin	Homo sapiens	70-79
12911619-6	2003	Increased homer 1a mRNA levels were found in 2 sets of cultures: in those exposed to thapsigargin, a specific inhibitor of ER Ca2+-ATPase, after a transient depletion of ER calcium stores through exposure to calcium-free medium supplemented with EGTA, and in those exposed to a proteasome inhibitor known to induce ER dysfunction.	Egtazic Acid	246-250	homer scaffold protein 1	Homo sapiens	10-18
12886466-7	2003	Desmin intermediate filaments were detected by immunofluorescence microscopy in a fragmented network dispersed within the entire cytoplasm in EGTA-treated cells, whereas a dense network was seen in the whole cytoplasm of control cells.	Egtazic Acid	142-146	desmin	Mus musculus	0-6
12851718-6	2003	Regucalcin significantly reduced NO synthase activity in the presence of TFP (50 micro micro M) or EGTA (1 mM) which has a significant inhibitory effect on the enzyme activity.	Egtazic Acid	99-103	regucalcin	Rattus norvegicus	0-10
12818356-4	2003	It was also demonstrated that Ca(++) influx was an essential feature, as EGTA diminished or abolished CD69 increased expression.	Egtazic Acid	73-77	CD69 antigen	Mus musculus	102-106
21072610-4	2003	Addition of EGTA could disassociate the actin-gelsolin complexes, reducing the ratio to 1.2+-0.23, and the addition of PIP(2) could further reduce the ratio to 0.8+-0.1.	Egtazic Acid	12-16	gelsolin	Homo sapiens	46-54
12882793-10	2003	Compatible with its transport function, the EGTA- and ouabain-insensitive ATPase activity of purified RLIP76 was stimulated by DNP-SG and GS-HNE.	Egtazic Acid	44-48	ralA binding protein 1	Homo sapiens	102-108
12929934-10	2003	RESULTS AND CONCLUSIONS: PTH and PDBu effects were attenuated by EGTA, BAPTA, nifedipine, and dantrolene, whereas ionomycin or 2X calcium increased basal PLD activity.	Egtazic Acid	65-69	parathyroid hormone	Rattus norvegicus	25-28
12784084-6	2003	The contractile response to 10 nmol/l ET-1 in 2.5 mmol/l Ca(2+ )(1.2 +/- 0.2 g) was significantly inhibited either in Ca(2+)-free solution containing 100 micromol/l ethylene glycol bis-(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (0.6 +/- 0.1 g) or after depletion of intracellular Ca(2+) stores (0.62 +/- 0.05 g).	Egtazic Acid	165-235	endothelin 1	Rattus norvegicus	38-42
12858345-6	2003	The effect of regucalcin (10(-7) M) in decreasing NO synthase activity was also seen in the presence of TFP (50 microM) or EGTA (1 mM).	Egtazic Acid	123-127	regucalcin	Rattus norvegicus	14-24
12787396-6	2003	METHODS: PTH secretion was examined during ethyleneglycol tetraacetic acid (EGTA)-induced hypocalcemia both with and without PTHrP.	Egtazic Acid	43-74	parathyroid hormone	Rattus norvegicus	9-12
12787396-6	2003	METHODS: PTH secretion was examined during ethyleneglycol tetraacetic acid (EGTA)-induced hypocalcemia both with and without PTHrP.	Egtazic Acid	76-80	parathyroid hormone	Rattus norvegicus	9-12
12746290-4	2003	The stretch-induced phosphorylation of CAKbeta was inhibited completely by an intracellular Ca(2+) chelator [1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetrakis(acetoxymethyl ester)] and largely by gadolinium, but only partially by an extracellular Ca(2+) chelator (EGTA).	Egtazic Acid	280-284	protein tyrosine kinase 2 beta	Rattus norvegicus	39-46
12857801-4	2003	The expression of hsp26 and hsp70 genes was up-regulated by the addition of CaCl(2) and down-regulated by the calcium ion chelator EGTA, the calcium ion channel blockers LaCl(3) and verapamil, or the CaM antagonists N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide and chlorpromazine.	Egtazic Acid	131-135	heat shock 70 kDa protein 4	Triticum aestivum	28-33
12746290-7	2003	Stretch-induced phosphorylation of ERK1/2 was inhibited by EGTA and an inhibitor of the Src kinase family [4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine], but not by cytochalasin D, to disrupt actin polymerization.	Egtazic Acid	59-63	mitogen activated protein kinase 3	Rattus norvegicus	35-41
12686401-5	2003	The effect of regucalcin (10(-8) M) in decreasing brain cytosolic NO synthase activity was not seen in the presence of Nw-nitro-L-argine methyl ester (NAME) (10(-4) M), trifluoperazine (20 micro M) or EGTA (1 mM).	Egtazic Acid	201-205	regucalcin	Rattus norvegicus	14-24
12804137-5	2003	Increased levels of interleukin 8 (IL-8) were secreted from EGTA-pretreated cystic fibrosis HAE cells after apical application of Pseudomonas aeruginosa (10(8) CFU/ml), whereas IL-8 secretion from C10- and C12-pretreated cells was not different from controls.	Egtazic Acid	60-64	chromosome 12 open reading frame 57	Homo sapiens	197-200
12804137-7	2003	EGTA increased BALF cell counts, neutrophils, and murine (m) macrophage inflammatory protein 2, mKC, mIL-6, and mIL-1 beta levels.	Egtazic Acid	0-4	interleukin 6	Mus musculus	101-106
12804137-7	2003	EGTA increased BALF cell counts, neutrophils, and murine (m) macrophage inflammatory protein 2, mKC, mIL-6, and mIL-1 beta levels.	Egtazic Acid	0-4	interleukin 1 beta	Mus musculus	112-122
12684708-6	2003	Furthermore, monolayers pre-incubated with 43-kDa outer-membrane protein (OMP) or A. caviae strains pre-incubated with rabbit IgG anti-43-kDa OMP decreased adherence of some A. caviae strains to EGTA-treated polarised and differentiated Caco-2 cells, suggesting an interaction of 43-kDa OMP with basolateral cell receptors.	Egtazic Acid	195-199	olfactory marker protein	Homo sapiens	142-145
12871376-9	2003	To better identify a secondary contribution of beta2-integrins, P-selectin interactions were disrupted by briefly adding 5 mm EGTA to already-formed mixed cell aggregates.	Egtazic Acid	126-130	selectin, platelet	Mus musculus	64-74
12871376-11	2003	The combination of brief EGTA treatment and a monoclonal antibody to beta2-integrin lowered the percentage of PMN with attached platelets to 50 +/- 7% and reduced the number of platelets attached per positive PMN to 3.6 +/- 0.7 (P = 0.03 vs. brief EGTA treatment only).	Egtazic Acid	248-252	hemoglobin, beta adult minor chain	Mus musculus	69-74
12871376-13	2003	When the incubation was stopped with EGTA the Src inhibitors PP1 and PP2 reduced PMN-platelet adhesion, while the inactive analog PP3 was ineffective.	Egtazic Acid	37-41	protein phosphatase 1 catalytic subunit gamma	Mus musculus	61-64
12871376-13	2003	When the incubation was stopped with EGTA the Src inhibitors PP1 and PP2 reduced PMN-platelet adhesion, while the inactive analog PP3 was ineffective.	Egtazic Acid	37-41	neuropeptide Y receptor Y6	Mus musculus	69-72
12759889-4	2003	Insulin and ATP each induced a dose-dependent phosphorylation of p44/42 MAPK that was partially inhibited by EGTA.	Egtazic Acid	109-113	mitogen activated protein kinase 3	Rattus norvegicus	65-68
12732268-6	2003	Conversely, stretch-induced BNP gene expression is suppressed by EGTA, stretch-activated ion channel inhibitors, voltage-dependent calcium channel antagonists, and long-time exposure to thapsigargin.	Egtazic Acid	65-69	natriuretic peptide B	Homo sapiens	28-31
12684708-6	2003	Furthermore, monolayers pre-incubated with 43-kDa outer-membrane protein (OMP) or A. caviae strains pre-incubated with rabbit IgG anti-43-kDa OMP decreased adherence of some A. caviae strains to EGTA-treated polarised and differentiated Caco-2 cells, suggesting an interaction of 43-kDa OMP with basolateral cell receptors.	Egtazic Acid	195-199	olfactory marker protein	Homo sapiens	142-145
12691666-7	2003	The effects of different extracellular Ca2+ concentrations and of EGTA indicated that PPF in CB-containing terminals depended on Ca2+ influx rather than on the initial release probability.	Egtazic Acid	66-70	calbindin 1	Mus musculus	93-95
12721390-7	2003	Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure.	Egtazic Acid	78-82	interleukin 6	Homo sapiens	101-105
12647304-6	2003	The effect of regucalcin (0.25 microM) in decreasing NO synthase activity was seen in the presence of ethylene glycol bis-(2-aminoethylether) N,N,N",N"-tetraacetic acid (EGTA, 1 mM) or TFP (20 microM), indicating that regucalcin acts independent on Ca(2+)/calmodulin.	Egtazic Acid	102-168	regucalcin	Rattus norvegicus	14-24
12647304-6	2003	The effect of regucalcin (0.25 microM) in decreasing NO synthase activity was seen in the presence of ethylene glycol bis-(2-aminoethylether) N,N,N",N"-tetraacetic acid (EGTA, 1 mM) or TFP (20 microM), indicating that regucalcin acts independent on Ca(2+)/calmodulin.	Egtazic Acid	170-174	regucalcin	Rattus norvegicus	14-24
12679466-10	2003	Cells treated with either BAPTA-AM or EGTA had significantly reduced PGDH activity; and, at intermediate concentrations of chelator, exogenous CRH restored PGDH activity.	Egtazic Acid	38-42	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	69-73
12679466-10	2003	Cells treated with either BAPTA-AM or EGTA had significantly reduced PGDH activity; and, at intermediate concentrations of chelator, exogenous CRH restored PGDH activity.	Egtazic Acid	38-42	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	156-160
12660222-4	2003	The intracellular calcium chelator EGTA-acetoxymethylester reduced 5-LOX activity and apoptosis to 30-40% of controls, whereas the p38 mitogen-activated protein kinase inhibitor SB203580 was ineffective.	Egtazic Acid	35-39	arachidonate 5-lipoxygenase	Homo sapiens	67-72
12711813-4	2003	The 72 kDa protease activity was found to be inhibited by EGTA, 1 : 10-phenanthroline, a2-macroglobulin and tissue inhibitor of metalloprotease-2 (TIMP-2) indicating that the Ca2+-dependent 72 kDa protease is the MMP-2.	Egtazic Acid	58-62	TIMP metallopeptidase inhibitor 2	Bos taurus	147-153
12650981-4	2003	The release of [125I]BDNF was found to be dependent on the concentrations of both extracellular and intracellular calcium, since BDNF release was modulated by the addition of both EGTA and BAPTA-AM, agents chelating either external or internal Ca(2+), respectively.	Egtazic Acid	180-184	brain-derived neurotrophic factor	Rattus norvegicus	21-25
12650981-4	2003	The release of [125I]BDNF was found to be dependent on the concentrations of both extracellular and intracellular calcium, since BDNF release was modulated by the addition of both EGTA and BAPTA-AM, agents chelating either external or internal Ca(2+), respectively.	Egtazic Acid	180-184	brain-derived neurotrophic factor	Rattus norvegicus	129-133
12627981-8	2003	However, protein adsorption curves starting from an EGTA-containing solution with soluble annexin A2t always show two inflection points upon addition of Ca2+ ions.	Egtazic Acid	52-56	annexin A2	Homo sapiens	90-100
12799067-7	2003	Inhibition of the basolateral Ca(2+)-dependent K(+) channel-rSK4-with serosal clotrimazole or incubation with mucosal Ca(2+)-free (EGTA) buffer completely prevented precytolytic TDC-induced increase in I(SC).	Egtazic Acid	131-135	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	60-64
12711813-4	2003	The 72 kDa protease activity was found to be inhibited by EGTA, 1 : 10-phenanthroline, a2-macroglobulin and tissue inhibitor of metalloprotease-2 (TIMP-2) indicating that the Ca2+-dependent 72 kDa protease is the MMP-2.	Egtazic Acid	58-62	matrix metallopeptidase 2	Bos taurus	213-218
12711813-8	2003	Both basal and H2O2 stimulated MMP-2 activity and Ca2+ATPase activity were inhibited by the general inhibitors of matrix metalloproteases: EGTA, 1 : 10-phenanthroline, a2-macroglobulin and also by TIMP-2 (the specific inhibitor of MMP-2) indicating that H2O2 increased MMP-2 activity and that subsequently stimulated Ca2+ATPase activity in the plasma membrane.	Egtazic Acid	139-143	matrix metallopeptidase 2	Bos taurus	31-36
12711813-8	2003	Both basal and H2O2 stimulated MMP-2 activity and Ca2+ATPase activity were inhibited by the general inhibitors of matrix metalloproteases: EGTA, 1 : 10-phenanthroline, a2-macroglobulin and also by TIMP-2 (the specific inhibitor of MMP-2) indicating that H2O2 increased MMP-2 activity and that subsequently stimulated Ca2+ATPase activity in the plasma membrane.	Egtazic Acid	139-143	carbonic anhydrase 2	Bos taurus	50-60
12711813-8	2003	Both basal and H2O2 stimulated MMP-2 activity and Ca2+ATPase activity were inhibited by the general inhibitors of matrix metalloproteases: EGTA, 1 : 10-phenanthroline, a2-macroglobulin and also by TIMP-2 (the specific inhibitor of MMP-2) indicating that H2O2 increased MMP-2 activity and that subsequently stimulated Ca2+ATPase activity in the plasma membrane.	Egtazic Acid	139-143	TIMP metallopeptidase inhibitor 2	Bos taurus	197-203
12711813-8	2003	Both basal and H2O2 stimulated MMP-2 activity and Ca2+ATPase activity were inhibited by the general inhibitors of matrix metalloproteases: EGTA, 1 : 10-phenanthroline, a2-macroglobulin and also by TIMP-2 (the specific inhibitor of MMP-2) indicating that H2O2 increased MMP-2 activity and that subsequently stimulated Ca2+ATPase activity in the plasma membrane.	Egtazic Acid	139-143	matrix metallopeptidase 2	Bos taurus	231-236
12711813-8	2003	Both basal and H2O2 stimulated MMP-2 activity and Ca2+ATPase activity were inhibited by the general inhibitors of matrix metalloproteases: EGTA, 1 : 10-phenanthroline, a2-macroglobulin and also by TIMP-2 (the specific inhibitor of MMP-2) indicating that H2O2 increased MMP-2 activity and that subsequently stimulated Ca2+ATPase activity in the plasma membrane.	Egtazic Acid	139-143	matrix metallopeptidase 2	Bos taurus	231-236
12711813-8	2003	Both basal and H2O2 stimulated MMP-2 activity and Ca2+ATPase activity were inhibited by the general inhibitors of matrix metalloproteases: EGTA, 1 : 10-phenanthroline, a2-macroglobulin and also by TIMP-2 (the specific inhibitor of MMP-2) indicating that H2O2 increased MMP-2 activity and that subsequently stimulated Ca2+ATPase activity in the plasma membrane.	Egtazic Acid	139-143	carbonic anhydrase 2	Bos taurus	317-327
12620374-6	2003	This activity was slightly modified in the presence of the calcium chelator EGTA and was blocked by competitive and irreversible NOS inhibitors, as well as by selective blockers of iNOS.	Egtazic Acid	76-80	nitric oxide synthase 2, inducible	Mus musculus	181-185
12568801-6	2003	Although the optimal temperature of LAP activity was 40 degrees C, the enzyme was active over a broad temperature range from 2 to 60 degrees C. Among a number of inhibitors tested, heavy metals and 1,10-phenanthroline completely inhibited the enzyme, while methanol, ethanol and EGTA stimulated somewhat LAP activity.	Egtazic Acid	279-283	leucine aminopeptidase 3	Homo sapiens	36-39
12388289-8	2003	In Ca(2+)-free (2 mM EGTA) Hanks" solution, the ANG II- and caffeine (10 mM)-induced [Ca(2+)](i) transient and cell contraction were not different between normal pregnant and RUPP rats, suggesting no difference in Ca(2+) release from the intracellular stores.	Egtazic Acid	21-25	angiotensinogen	Rattus norvegicus	48-54
12414897-7	2002	This protease activity was dependent on the presence of IGF-II, and its metal ion dependence was demonstrated by inhibition of the protease by the metal chelators, EDTA and EGTA.	Egtazic Acid	173-177	insulin like growth factor 2	Homo sapiens	56-62
14580939-4	2003	EGTA and a specific inhibitor of sPLA2 activity, 12-epi-scalaradial, abolished the increase in neurotransmitter release, indicating that the effect of sPLA2 was dependent on calcium and sPLA2 enzymatic activity.	Egtazic Acid	0-4	phospholipase A2 group IIA	Rattus norvegicus	151-156
14580939-4	2003	EGTA and a specific inhibitor of sPLA2 activity, 12-epi-scalaradial, abolished the increase in neurotransmitter release, indicating that the effect of sPLA2 was dependent on calcium and sPLA2 enzymatic activity.	Egtazic Acid	0-4	phospholipase A2 group IIA	Rattus norvegicus	151-156
12486211-10	2002	In separate experiments, application with anti-cadherin-5 antibody or treatment with EGTA attenuated VE-cadherin expression and further enhanced wound closure compared with control shear and all static conditions.	Egtazic Acid	85-89	cadherin 5	Homo sapiens	101-112
12220617-5	2002	Both DNA synthesis and phosphorylation of MAPK in response to SP were attenuated by pretreatment with pertussis toxin, genistein, D609, U73122, staurosporine, removal of Ca(2+) by BAPTA/AM plus EGTA, PD98059, and SB202190.	Egtazic Acid	194-198	tachykinin precursor 1	Homo sapiens	62-64
12457870-7	2002	Both EGTA and actinomycin partially inhibited the thapsigargin-induced SERCA3 up-regulation.	Egtazic Acid	5-9	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	71-77
12372622-3	2002	The HeLa cells apoptosis induced by HAP proteins was not prevented by establishing the clamped cytosolic Ca(2+) condition, or by buffering of the extracellular Ca(2+) with EGTA, suggesting that the depletion of ER Ca(2+) stores rather than the elevation of cytosolic Ca(2+) or the extracellular Ca(2+) entry contributed to HAP-induced HeLa cells apoptosis.	Egtazic Acid	172-176	reticulon 3	Homo sapiens	36-39
12215383-2	2002	The assay is sensitive to inhibition by ethylene glycol bis-(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) (which allows alternative pathway activation), ethylene diamine tetraacetic acid (EDTA), mannose, N-acetylglucosamine and C1 esterase inhibitor (C1-INH), whereas it was not inhibited by galactose.	Egtazic Acid	112-116	serpin family G member 1	Homo sapiens	240-261
12215383-2	2002	The assay is sensitive to inhibition by ethylene glycol bis-(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) (which allows alternative pathway activation), ethylene diamine tetraacetic acid (EDTA), mannose, N-acetylglucosamine and C1 esterase inhibitor (C1-INH), whereas it was not inhibited by galactose.	Egtazic Acid	112-116	serpin family G member 1	Homo sapiens	263-269
12558054-7	2002	Cells incubated with VEGF in the presence of EGTA showed a marked decrease in arachidonate mobilization, whereas incubation with the calcium ionophore A23187 alone produced an increase in arachidonate, although to a lesser extent compared with the VEGF stimulation.	Egtazic Acid	45-49	vascular endothelial growth factor A	Homo sapiens	21-25
12558054-7	2002	Cells incubated with VEGF in the presence of EGTA showed a marked decrease in arachidonate mobilization, whereas incubation with the calcium ionophore A23187 alone produced an increase in arachidonate, although to a lesser extent compared with the VEGF stimulation.	Egtazic Acid	45-49	vascular endothelial growth factor A	Homo sapiens	248-252
12097138-5	2002	Inhibitory effects of EGTA on glucose-6-phosphatase activity previously reported in histone 2A-treated microsomes have been also found in alamethicin-permeabilized vesicles.	Egtazic Acid	22-26	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	30-51
12384539-8	2002	Treatment with concanamycin A or EGTA abrogated CD8+ NKT cytotoxicity indicating that perforin is a major pathway of tumor cell lysis.	Egtazic Acid	33-37	CD8a molecule	Homo sapiens	48-51
12084723-7	2002	NaCl-induced ENA1 expression was inhibited by EGTA, cch1Delta mutation, and FK506, indicating that the [Ca(2+)](cyt) transient activates calcineurin signaling to mediate ion homeostasis and salt tolerance.	Egtazic Acid	46-50	Na(+)/Li(+)-exporting P-type ATPase ENA1	Saccharomyces cerevisiae S288C	13-17
12239162-7	2002	Selective MEK1/2 inhibition by U-0126 and Ca(++) chelation with EGTA (ethyleneglycoltetraacetic acid) behaved similarly, whereas the PKC inhibitor GF109203-X totally prevented collagen-induced secretion and ERK2 activation.	Egtazic Acid	64-68	mitogen-activated protein kinase kinase 1	Homo sapiens	10-16
12239162-7	2002	Selective MEK1/2 inhibition by U-0126 and Ca(++) chelation with EGTA (ethyleneglycoltetraacetic acid) behaved similarly, whereas the PKC inhibitor GF109203-X totally prevented collagen-induced secretion and ERK2 activation.	Egtazic Acid	70-100	mitogen-activated protein kinase kinase 1	Homo sapiens	10-16
12138163-3	2002	The gating of TRPV6 channels is strongly dependent on the cytosolic free Ca(2+) concentration; lowering the intracellular free Ca(2+) concentration results in Ca(2+) influx, and current amplitude correlates with the intracellular EGTA or BAPTA concentration.	Egtazic Acid	230-234	transient receptor potential cation channel subfamily V member 6	Homo sapiens	14-19
12231642-12	2002	Ouabain-induced c-Fos expression was also insensitive to the presence of nicardipine and [Ca(2+)](o), as well as chelators of [Ca(2+)](o) (EGTA) and [Ca(2+)](i) (BAPTA).	Egtazic Acid	139-143	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
12205180-8	2002	High concentration of Ca2+ buffers (2-5 mM EGTA plus 1 mM fluo-3) completely abolished the I(Ca)-gated propagation wave and the slow delayed component of Ca2+ release, but had little or no effect on the rapid component of central release.	Egtazic Acid	43-47	carbonic anhydrase 2	Rattus norvegicus	22-25
12205180-8	2002	High concentration of Ca2+ buffers (2-5 mM EGTA plus 1 mM fluo-3) completely abolished the I(Ca)-gated propagation wave and the slow delayed component of Ca2+ release, but had little or no effect on the rapid component of central release.	Egtazic Acid	43-47	carbonic anhydrase 2	Rattus norvegicus	154-157
12486867-9	2002	After induction of a brief period of hypocalcaemia by infusion of EGTA a significant (P &lt; 0.01) and rapid recovery of plasma Ca2+ took place within 10 min and a further increase within the next 60 min (P &lt; 0.01), whether or not the rats were normal, TPTX, TX or were supplemented by CT during the experiments.	Egtazic Acid	66-70	calcitonin-related polypeptide alpha	Rattus norvegicus	289-291
12221118-8	2002	Plasma membrane allocation of inversin is dependent upon cell-cell contacts and was redistributed when cell adhesion was disrupted after incubation of the cell monolayer with low-calcium/EGTA medium.	Egtazic Acid	187-191	inversin	Mus musculus	30-38
12105215-6	2002	The SAP155 kinases in cell lysates were blocked by the Ca(2+) chelator EGTA and by the cyclin-dependent protein kinase inhibitor roscovitine.	Egtazic Acid	71-75	splicing factor 3b subunit 1	Homo sapiens	4-10
12236590-6	2002	The oxidant triggered protease activity and the Ca2+ATPase activity were found to be prevented by the antioxidant vitamin E, and also by the Ca2+ dependent matrix metalloprotease inhibitors: EGTA and TIMP-2.	Egtazic Acid	191-195	carbonic anhydrase 2	Bos taurus	48-58
12145335-5	2002	Hormonal activation of constructs containing p53 promoter inserts (-106 to -40) and the GAL4-p65 fusion proteins was inhibited by the intracellular Ca2+ ion chelator EGTA-AM and Ca2+/calmodulin-dependent protein kinase (CaMK) inhibitor KN-93.	Egtazic Acid	166-170	tumor protein p53	Homo sapiens	45-48
12145335-5	2002	Hormonal activation of constructs containing p53 promoter inserts (-106 to -40) and the GAL4-p65 fusion proteins was inhibited by the intracellular Ca2+ ion chelator EGTA-AM and Ca2+/calmodulin-dependent protein kinase (CaMK) inhibitor KN-93.	Egtazic Acid	166-170	galectin 4	Homo sapiens	88-92
12145335-5	2002	Hormonal activation of constructs containing p53 promoter inserts (-106 to -40) and the GAL4-p65 fusion proteins was inhibited by the intracellular Ca2+ ion chelator EGTA-AM and Ca2+/calmodulin-dependent protein kinase (CaMK) inhibitor KN-93.	Egtazic Acid	166-170	RELA proto-oncogene, NF-kB subunit	Homo sapiens	93-96
12027460-8	2002	Suggesting that low [Ca(2+)](i) suppression of hypertrophy was PTHrP-dependent in GPCs, (a) treatment with 4 mM EGTA increased PTHrP expression, (b) the EGTA effect was rescued by blocking PTHrP binding to its receptor with the competitive antagonist TIP(7-39), and (c) EGTA could mimic the PTHrP stimulation of AP-1 binding to DNA.	Egtazic Acid	153-157	parathyroid hormone like hormone	Homo sapiens	63-68
12102631-1	2002	Cytochrome c oxidase (COX) from R. sphaeroides contains one Ca(2+) ion per enzyme that is not removed by dialysis versus EGTA.	Egtazic Acid	121-125	cytochrome c oxidase subunit 7A1	Bos taurus	22-25
12027460-8	2002	Suggesting that low [Ca(2+)](i) suppression of hypertrophy was PTHrP-dependent in GPCs, (a) treatment with 4 mM EGTA increased PTHrP expression, (b) the EGTA effect was rescued by blocking PTHrP binding to its receptor with the competitive antagonist TIP(7-39), and (c) EGTA could mimic the PTHrP stimulation of AP-1 binding to DNA.	Egtazic Acid	112-116	parathyroid hormone like hormone	Homo sapiens	63-68
12049843-9	2002	The increase in [Ca(2+)](i) produced by PCBC (100 microM) was prevented by treatment with AOAA, and markedly reduced by a nominally calcium free medium or the addition of the calcium chelator EGTA.	Egtazic Acid	192-196	EPH receptor B2	Homo sapiens	40-44
12027460-8	2002	Suggesting that low [Ca(2+)](i) suppression of hypertrophy was PTHrP-dependent in GPCs, (a) treatment with 4 mM EGTA increased PTHrP expression, (b) the EGTA effect was rescued by blocking PTHrP binding to its receptor with the competitive antagonist TIP(7-39), and (c) EGTA could mimic the PTHrP stimulation of AP-1 binding to DNA.	Egtazic Acid	112-116	parathyroid hormone like hormone	Homo sapiens	127-132
12027460-8	2002	Suggesting that low [Ca(2+)](i) suppression of hypertrophy was PTHrP-dependent in GPCs, (a) treatment with 4 mM EGTA increased PTHrP expression, (b) the EGTA effect was rescued by blocking PTHrP binding to its receptor with the competitive antagonist TIP(7-39), and (c) EGTA could mimic the PTHrP stimulation of AP-1 binding to DNA.	Egtazic Acid	112-116	parathyroid hormone like hormone	Homo sapiens	127-132
12027460-8	2002	Suggesting that low [Ca(2+)](i) suppression of hypertrophy was PTHrP-dependent in GPCs, (a) treatment with 4 mM EGTA increased PTHrP expression, (b) the EGTA effect was rescued by blocking PTHrP binding to its receptor with the competitive antagonist TIP(7-39), and (c) EGTA could mimic the PTHrP stimulation of AP-1 binding to DNA.	Egtazic Acid	112-116	parathyroid hormone like hormone	Homo sapiens	127-132
12027460-8	2002	Suggesting that low [Ca(2+)](i) suppression of hypertrophy was PTHrP-dependent in GPCs, (a) treatment with 4 mM EGTA increased PTHrP expression, (b) the EGTA effect was rescued by blocking PTHrP binding to its receptor with the competitive antagonist TIP(7-39), and (c) EGTA could mimic the PTHrP stimulation of AP-1 binding to DNA.	Egtazic Acid	153-157	parathyroid hormone like hormone	Homo sapiens	63-68
11950929-5	2002	spf1-null mutants are modestly sensitive to EGTA.	Egtazic Acid	44-48	ion-transporting P-type ATPase SPF1	Saccharomyces cerevisiae S288C	0-4
11916969-3	2002	Rat and human SP-D bound the organism with high affinity in a reaction that required Ca(2+) and was inhibited by EGTA.	Egtazic Acid	113-117	surfactant protein D	Homo sapiens	14-18
11959652-5	2002	EGTA, N-acetyl-cysteine, and superoxide dismutase attenuated the hyperplastic response to substance P.	Egtazic Acid	0-4	tachykinin precursor 1	Homo sapiens	90-101
11976903-7	2002	Upon opening of the TJs under short-term treatment with EGTA (up to 20 min), the localization of ZO1-CGFP at the membrane persisted.	Egtazic Acid	56-60	tight junction protein 1	Canis lupus familiaris	97-100
11867690-5	2002	Furthermore, pretreatment of the cells with the Ca(2)(+) chelator EGTA, which depletes the intracellular Ca(2)(+), inhibited the effects of mAb KIM-127 on cell morphology and PYK2 activation.	Egtazic Acid	66-70	PTK2 protein tyrosine kinase 2 beta	Mus musculus	175-179
12102173-7	2002	Under both basal and ONOO- triggered conditions, the MMP-2 activity and the Ca2+ ATPase activity were also inhibited by EGTA, 1:10-phenanthroline, and TIMP-2.	Egtazic Acid	120-124	matrix metallopeptidase 2	Bos taurus	53-58
12102173-7	2002	Under both basal and ONOO- triggered conditions, the MMP-2 activity and the Ca2+ ATPase activity were also inhibited by EGTA, 1:10-phenanthroline, and TIMP-2.	Egtazic Acid	120-124	carbonic anhydrase 2	Bos taurus	76-87
12047811-9	2002	Pretreatment with EGTA (5 mM) and thapsigargin (10 microM) decreased the BFP-induced I(SC) by 10%.	Egtazic Acid	18-22	ring finger protein 112	Homo sapiens	73-76
11875099-8	2002	Experiments with EGTA or calcium channel antagonists indicated that calcium influx is important for the induction of both genes by GnRH.	Egtazic Acid	17-21	gonadotropin releasing hormone 1	Mus musculus	131-135
11952151-6	2002	Annexin V was found to be stable to intrinsic lung proteases in the presence of either Ca2+ or EGTA while annexin XI was found to be partially degraded by intrinsic lung proteases in the presence of EGTA.	Egtazic Acid	95-99	annexin A5	Homo sapiens	0-9
11833091-8	2002	When the extracellular Ca2+ was eliminated by 2 mmol x L(-1) EGTA and 5 micromol x L(-1) verapamil, the intracellular Ca2+ increases induced by KCl, ACh and CCK were 20+/-14%,82+/-21% and 104+/-23%, respectively.	Egtazic Acid	61-65	cholecystokinin	Oryctolagus cuniculus	157-160
11952151-6	2002	Annexin V was found to be stable to intrinsic lung proteases in the presence of either Ca2+ or EGTA while annexin XI was found to be partially degraded by intrinsic lung proteases in the presence of EGTA.	Egtazic Acid	199-203	annexin A11	Homo sapiens	106-116
11967991-3	2002	This decrease was also seen in the presence of Ca2+-chelator EGTA (0.4 mM), indicating that the effect of regucalcin is not related to nuclear Ca2+.	Egtazic Acid	61-65	regucalcin	Rattus norvegicus	106-116
11707462-5	2002	Sufficient CaM was retained after skinning (demembranation) of rat tail arterial smooth muscle in the presence of EGTA to support Ca(2+)-evoked contraction, as observed previously with other smooth muscle tissues.	Egtazic Acid	114-118	calmodulin 1	Rattus norvegicus	11-14
11779483-4	2002	The effects of BAPTA and EGTA indicate that vesicles comprising the RRP were docked at variable distances from Ca(2+) channels.	Egtazic Acid	25-29	rhomboid like 1	Homo sapiens	68-71
11914123-4	2002	RESULTS: Pretreatment of the cells with the Ca2+ chelators BAPTA-AM or EGTA, as well as the Ca2+ influx inhibitor gadolinium, resulted in a partial decrease of the ERK response.	Egtazic Acid	71-75	mitogen-activated protein kinase 1	Homo sapiens	164-167
11484192-3	2001	After 5 or 60 min of incubations in whole normal or EGTA sera, antibodies against complement factor 3 (C3) and complement factor 3d (C3d) deposited to the surface.	Egtazic Acid	52-56	complement C3	Homo sapiens	82-101
11761027-6	2001	The colonic mucin output induced by these two secretagogues was significantly inhibited by arterial administration of EGTA (2 mM), verapamil (100 microM) or nifedipine (50 microM).	Egtazic Acid	118-122	solute carrier family 13 member 2	Rattus norvegicus	12-17
11748634-4	2002	Following agrin"s activation of MuSK, we find that the downstream tyrosine phosphorylation of the AChR beta-subunit was inhibited by BAPTA but not by a slower acting chelator, EGTA.	Egtazic Acid	176-180	cholinergic receptor nicotinic beta 1 subunit	Homo sapiens	98-107
11748634-5	2002	Similarly, agrin-induced clustering of the AChR was blocked by BAPTA but not EGTA.	Egtazic Acid	77-81	agrin	Homo sapiens	11-16
11936841-4	2002	Regucalcin (0.1-0.5 microM) added in the reaction mixture in the presence of either EGTA (1 mM) or calcium chloride (50 microM) had a significant inhibitory effect on nuclear DNA synthesis activity.	Egtazic Acid	84-88	regucalcin	Rattus norvegicus	0-10
11936841-7	2002	The effect of anti-regucalcin monoclonal antibody in increasing DNA synthesis was enhanced in the presence of EGTA.	Egtazic Acid	110-114	regucalcin	Rattus norvegicus	19-29
11755212-2	2001	In this study we show that intracellular and extracellular Ca2+ chelation with BAPTA and EGTA, respectively, blocked hormone stimulation of c-Src activity/dephosphorylation, indicating that the calcium messenger system is an upstream activator of c-Src.	Egtazic Acid	89-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	140-145
11755212-2	2001	In this study we show that intracellular and extracellular Ca2+ chelation with BAPTA and EGTA, respectively, blocked hormone stimulation of c-Src activity/dephosphorylation, indicating that the calcium messenger system is an upstream activator of c-Src.	Egtazic Acid	89-93	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	247-252
11733938-4	2001	In a Ca2+-free medium (EGTA added), addition of 0.1 U/ml thrombin caused an elevation in [Ca2+]i. Preincubation with 100 microM 2-APB for 170s abolished the release of internal Ca2+.	Egtazic Acid	23-27	coagulation factor II, thrombin	Homo sapiens	57-65
11484192-3	2001	After 5 or 60 min of incubations in whole normal or EGTA sera, antibodies against complement factor 3 (C3) and complement factor 3d (C3d) deposited to the surface.	Egtazic Acid	52-56	complement C3	Homo sapiens	103-105
11484192-3	2001	After 5 or 60 min of incubations in whole normal or EGTA sera, antibodies against complement factor 3 (C3) and complement factor 3d (C3d) deposited to the surface.	Egtazic Acid	52-56	complement C3	Homo sapiens	111-130
11509543-8	2001	Treatment of VSMC with the intracellular Ca(2+) chelator EGTA-AM (50 micromol/l) significantly increased ERK phosphorylation induced by native and mildly modified LDL, whereas chelation of extracellular Ca(2+) by EGTA (3 mmol/l) significantly reduced LDL-induced ERK phosphorylation.	Egtazic Acid	57-61	Eph receptor B1	Rattus norvegicus	105-108
11600671-4	2001	The calcium waves persisted in fibres exposed to EGTA-containing solutions, during sustained depolarization of the membrane potential or following treatment with the dihydropyridine receptor (DHPR)-blocker nifedipine.	Egtazic Acid	49-53	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	166-190
11600671-4	2001	The calcium waves persisted in fibres exposed to EGTA-containing solutions, during sustained depolarization of the membrane potential or following treatment with the dihydropyridine receptor (DHPR)-blocker nifedipine.	Egtazic Acid	49-53	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	192-196
11588099-7	2001	Monovalent cation currents were measured by use of the whole cell patch clamp technique in cells dialysed with 10 mM BAPTA or 10 mM EGTA to prevent the fast Ca(2+) dependent inactivation of ECaC1.	Egtazic Acid	132-136	transient receptor potential cation channel subfamily V member 5	Homo sapiens	190-195
11530010-6	2001	TPA and calcium chelating agents (BAPTA-AM and EGTA) blocked Pyk2 phosphorylation and HB-EGF gene expression.	Egtazic Acid	47-51	protein tyrosine kinase 2 beta	Rattus norvegicus	61-65
11592793-9	2001	Co-incubation with the reducing agent dithiothreitol or calcium chelators (EDTA/EGTA) inhibited partially or completely menadione"s effects on MEK/ERK and Akt pathways, as well as menadione"s effects on PDGF-induced ERK and Akt activations.	Egtazic Acid	80-84	Eph receptor B1	Rattus norvegicus	147-150
11592793-9	2001	Co-incubation with the reducing agent dithiothreitol or calcium chelators (EDTA/EGTA) inhibited partially or completely menadione"s effects on MEK/ERK and Akt pathways, as well as menadione"s effects on PDGF-induced ERK and Akt activations.	Egtazic Acid	80-84	AKT serine/threonine kinase 1	Rattus norvegicus	155-158
11592793-9	2001	Co-incubation with the reducing agent dithiothreitol or calcium chelators (EDTA/EGTA) inhibited partially or completely menadione"s effects on MEK/ERK and Akt pathways, as well as menadione"s effects on PDGF-induced ERK and Akt activations.	Egtazic Acid	80-84	Eph receptor B1	Rattus norvegicus	216-219
11592793-9	2001	Co-incubation with the reducing agent dithiothreitol or calcium chelators (EDTA/EGTA) inhibited partially or completely menadione"s effects on MEK/ERK and Akt pathways, as well as menadione"s effects on PDGF-induced ERK and Akt activations.	Egtazic Acid	80-84	AKT serine/threonine kinase 1	Rattus norvegicus	224-227
11495722-5	2001	The phospholipase C (PLC) inhibitor, U73122, and EGTA reduced the phosphorylation of both ERK1/2 and MEK1/2 induced by H(2)O(2).	Egtazic Acid	49-53	mitogen-activated protein kinase 3	Homo sapiens	90-96
11495722-5	2001	The phospholipase C (PLC) inhibitor, U73122, and EGTA reduced the phosphorylation of both ERK1/2 and MEK1/2 induced by H(2)O(2).	Egtazic Acid	49-53	mitogen-activated protein kinase kinase 1	Homo sapiens	101-107
11509543-8	2001	Treatment of VSMC with the intracellular Ca(2+) chelator EGTA-AM (50 micromol/l) significantly increased ERK phosphorylation induced by native and mildly modified LDL, whereas chelation of extracellular Ca(2+) by EGTA (3 mmol/l) significantly reduced LDL-induced ERK phosphorylation.	Egtazic Acid	57-61	Eph receptor B1	Rattus norvegicus	263-266
11530010-6	2001	TPA and calcium chelating agents (BAPTA-AM and EGTA) blocked Pyk2 phosphorylation and HB-EGF gene expression.	Egtazic Acid	47-51	heparin-binding EGF-like growth factor	Rattus norvegicus	86-92
11382780-6	2001	Expression of TcSCA in yeast mutants deficient in the Golgi and vacuolar Ca(2+) pumps (pmr1 pmc1 cnb 1) restored growth on EGTA.	Egtazic Acid	123-127	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	87-102
11460265-8	2001	Chelation of extracellular Ca2+ by EGTA (6 mM) or blockage of Ca2+ channels with Ni2+ (2 mM) abrogated the stimulatory effect of TTN.	Egtazic Acid	35-39	titin	Rattus norvegicus	129-132
11443038-5	2001	PEG profiling revealed significant differences between the effects of EGTA and sodium caprate (C10).	Egtazic Acid	70-74	homeobox C10	Homo sapiens	95-98
11510494-7	2001	Also, the effect of regucalcin addition in increasing nuclear GTPase activity was seen in the presence of EGTA (0.1 mM), a chelator of Ca2+.	Egtazic Acid	106-110	regucalcin	Rattus norvegicus	20-30
11323436-7	2001	Antibodies against Ykt6 inhibit in vitro ER-Golgi transport of vesicular stomatitis virus envelope glycoprotein (VSVG) only when they are added before the EGTA-sensitive stage.	Egtazic Acid	155-159	YKT6 v-SNARE homolog	Homo sapiens	19-23
11328807-7	2001	EGTA completely inhibits gelsolin translocation into the cytoskeleton, and the small amount of gelsolin initially there becomes soluble.	Egtazic Acid	0-4	gelsolin	Mus musculus	25-33
11418685-4	2001	We further show that Syk activation by c48/80 is blocked by the protein kinase C inhibitor GF109203X, by the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, by EGTA, and by the selective src-like kinase inhibitor PP1.	Egtazic Acid	179-183	spleen associated tyrosine kinase	Rattus norvegicus	21-24
11445066-6	2001	The VLP without disulfide bonds could be disassembled into capsomeres by EGTA alone, but those with disulfide bonds could not be disassembled by EGTA.	Egtazic Acid	73-77	VHL like	Homo sapiens	4-7
11406493-5	2001	LPC-stimulated PYK2 phosphorylation was inhibited by calcium chelators, 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester, EGTA, protein kinase C (PKC) inhibitor, GF-109203X, or PKC depletion by phorbol esters.	Egtazic Acid	150-154	protein tyrosine kinase 2 beta	Bos taurus	15-19
11510791-0	2001	EGTA treatment of human airways in vitro unmasks M1/MUC5AC mucin in submucosal glands.	Egtazic Acid	0-4	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	52-58
11510791-0	2001	EGTA treatment of human airways in vitro unmasks M1/MUC5AC mucin in submucosal glands.	Egtazic Acid	0-4	LOC100508689	Homo sapiens	59-64
11510791-3	2001	The aim of this investigation was to examine the effects of the calcium chelator, ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA) on the detection of M1/MUC5AC mucin in isolated human bronchial preparations.	Egtazic Acid	82-150	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	181-187
11510791-3	2001	The aim of this investigation was to examine the effects of the calcium chelator, ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA) on the detection of M1/MUC5AC mucin in isolated human bronchial preparations.	Egtazic Acid	82-150	LOC100508689	Homo sapiens	188-193
11510791-3	2001	The aim of this investigation was to examine the effects of the calcium chelator, ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA) on the detection of M1/MUC5AC mucin in isolated human bronchial preparations.	Egtazic Acid	152-156	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	181-187
11510791-3	2001	The aim of this investigation was to examine the effects of the calcium chelator, ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA) on the detection of M1/MUC5AC mucin in isolated human bronchial preparations.	Egtazic Acid	152-156	LOC100508689	Homo sapiens	188-193
11510791-6	2001	The quantities of M1/MUC5AC mucin detected in either the bronchial fluids derived from EGTA (4 mM)-exposed intact and rubbed preparations or in bronchial fluids treated with EGTA (4 mM) were significantly increased by two-fold when compared with untreated control values (p&lt;0.001).	Egtazic Acid	87-91	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	21-27
11510791-6	2001	The quantities of M1/MUC5AC mucin detected in either the bronchial fluids derived from EGTA (4 mM)-exposed intact and rubbed preparations or in bronchial fluids treated with EGTA (4 mM) were significantly increased by two-fold when compared with untreated control values (p&lt;0.001).	Egtazic Acid	87-91	LOC100508689	Homo sapiens	28-33
11510791-6	2001	The quantities of M1/MUC5AC mucin detected in either the bronchial fluids derived from EGTA (4 mM)-exposed intact and rubbed preparations or in bronchial fluids treated with EGTA (4 mM) were significantly increased by two-fold when compared with untreated control values (p&lt;0.001).	Egtazic Acid	174-178	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	21-27
11510791-8	2001	These results provide evidence that ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (4 mM) facilitates the detection of M1/MUC5AC mucin by altering the physicochemical properties of respiratory mucin, thereby exposing epitopes with which anti-M1 monoclonal antibodies are reactive.	Egtazic Acid	36-104	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	144-150
11510791-8	2001	These results provide evidence that ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (4 mM) facilitates the detection of M1/MUC5AC mucin by altering the physicochemical properties of respiratory mucin, thereby exposing epitopes with which anti-M1 monoclonal antibodies are reactive.	Egtazic Acid	36-104	LOC100508689	Homo sapiens	151-156
11510791-8	2001	These results provide evidence that ethyleneglycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (4 mM) facilitates the detection of M1/MUC5AC mucin by altering the physicochemical properties of respiratory mucin, thereby exposing epitopes with which anti-M1 monoclonal antibodies are reactive.	Egtazic Acid	36-104	LOC100508689	Homo sapiens	215-220
11418685-4	2001	We further show that Syk activation by c48/80 is blocked by the protein kinase C inhibitor GF109203X, by the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002, by EGTA, and by the selective src-like kinase inhibitor PP1.	Egtazic Acid	179-183	neuropeptide Y receptor Y4	Rattus norvegicus	232-235
11294648-2	2001	The processing of gp160 in these cells, infected with recombinant vaccinia virus encoding the gp160 gene, was only partially affected by intracellular calcium depletion induced by the calcium ionophore A23187 and calcium chelator EGTA.	Egtazic Acid	230-234	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	18-23
11399940-5	2001	Bradykinin induced an increment of [Ca2+]i in a concentration-dependent manner and its 50% effective concentration was approximately 5 x 10(-11) M. A [Ca2+]i increment at 10(-8) M bradykinin was inhibited with the pretreatment of EGTA, an extracellular calcium chelator.	Egtazic Acid	230-234	kininogen 1	Bos taurus	0-10
11399940-5	2001	Bradykinin induced an increment of [Ca2+]i in a concentration-dependent manner and its 50% effective concentration was approximately 5 x 10(-11) M. A [Ca2+]i increment at 10(-8) M bradykinin was inhibited with the pretreatment of EGTA, an extracellular calcium chelator.	Egtazic Acid	230-234	kininogen 1	Bos taurus	180-190
11352768-12	2001	The importance of calcium in mediating radiation damage to growth plate chondrocytes was further demonstrated by the finding that the addition of 4.0 mM EGTA (a calcium chelator) to the cell cultures before irradiation prevented the decrease in PTHrP mRNA levels.	Egtazic Acid	153-157	parathyroid hormone like hormone	Homo sapiens	245-250
11350048-3	2001	The Ca2+-induced inhibition was reversible since chelation of endogenous Ca2+ with EGTA increased 11beta-HSD2 activity up to 200%.	Egtazic Acid	83-87	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	98-109
11432453-9	2001	Moreover, the depletion of Ca2+ by EGTA enhanced TG- and Br-A23187-induced apoptosis, and reduced the anti-apoptotic action of bcl-2, suggesting that cytosolic Ca2+ elevation may be required for optimal ER pool refilling.	Egtazic Acid	35-39	BCL2 apoptosis regulator	Homo sapiens	127-132
11257314-5	2001	Forskolin- and VIP-responsive cAMP was greater in the combination (0 mM CaCl(2) + 0.5 mM EGTA + 3 mM CoCl2) than in the Ca(2+)-free perfusion alone.	Egtazic Acid	89-93	vasoactive intestinal peptide	Rattus norvegicus	15-18
11379045-4	2001	NG-monomethyl-L-arginine (L-NMMA) and EGTA inhibited the cytokine effect on amylase secretion, involving the participation of a calcium-dependent isoform of nitric oxide synthase (NOS).	Egtazic Acid	38-42	nitric oxide synthase 1, neuronal	Mus musculus	157-178
11356574-4	2001	The expression of the pmrA cDNA partially restored the growth defect of Yarrowia lipolytica pmr1 null mutant on EGTA-containing medium.	Egtazic Acid	112-116	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	92-96
11351097-11	2001	Glutamine plus sucrose induction of GUS activity was inhibited by EGTA, okadaic acid, or K-252A.	Egtazic Acid	66-70	glucuronidase beta	Homo sapiens	36-39
11336199-8	2001	In the absence of extracellular Ca2+ (plus 10 micromol/L EGTA), exposure to ADP (10 micromol/L) produced transient increases in Ca(i) (Ca2+ release) that were decreased in cells from LPS-treated versus CON animals.	Egtazic Acid	57-61	protein disulfide isomerase associated 4	Mus musculus	128-133
11294648-2	2001	The processing of gp160 in these cells, infected with recombinant vaccinia virus encoding the gp160 gene, was only partially affected by intracellular calcium depletion induced by the calcium ionophore A23187 and calcium chelator EGTA.	Egtazic Acid	230-234	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	94-99
11247938-6	2001	In strained constructs, treatment with either Ga3+ or EGTA significantly reduced the number of positive Ca2+ responders compared with untreated controls.	Egtazic Acid	54-58	carbonic anhydrase 2	Bos taurus	104-107
11247763-6	2001	When WC was used in cells dialyzed with low Ca(2+) buffer capacity (EGTA 0.1 mM), ANG II was able to induce an increase in I(Ca) (-3.5 +/- 0.3 in control vs. -4.8 +/- 0.4 pA/pF in ANG II, n = 13, P &lt; 0.05).	Egtazic Acid	68-72	angiotensinogen	Homo sapiens	82-88
11259266-5	2001	Exposure to EGTA reduced MEK and Akt kinase activity, whereas E-cadherin antibody only attenuated Akt kinase activity.	Egtazic Acid	12-16	mitogen-activated protein kinase kinase 7	Homo sapiens	25-28
11259266-7	2001	Caspase-3 activity increased after serum depletion, or EGTA or E-cadherin antibody treatment.	Egtazic Acid	55-59	caspase 3	Homo sapiens	0-9
11279605-5	2001	AP-N, which has zinc in the active center, was also inhibited by the chelating agents, EDTA, o-phenanthroline and EGTA.	Egtazic Acid	114-118	alanyl aminopeptidase, membrane	Homo sapiens	0-4
11341962-3	2001	PIP(2), EDTA/EGTA, and ATP were found to enhance basal PLD activity in vitro.	Egtazic Acid	13-17	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-58
11291934-2	2001	In islets cultured in low concentrations of glucose, the secretion of IAPP in response to glucose was unaffected by brefeldin A (BFA) and completely blocked by ethyleneglycoltetraacetic acid.	Egtazic Acid	160-190	islet amyloid polypeptide	Homo sapiens	70-74
11181077-7	2001	Treatment with EGTA or BAPTA/AM markedly inhibited the Pin-induced apoptosis.	Egtazic Acid	15-19	dynein light chain LC8-type 1	Homo sapiens	55-58
11329279-11	2001	The Tms that bound to actin (dAc2--3, dAc2--4, and dAc3--5) all fully inhibited the actomyosin ATPase (+Tn) in EGTA.	Egtazic Acid	111-115	dachshund	Drosophila melanogaster	29-36
11329279-11	2001	The Tms that bound to actin (dAc2--3, dAc2--4, and dAc3--5) all fully inhibited the actomyosin ATPase (+Tn) in EGTA.	Egtazic Acid	111-115	Adenylate cyclase 3	Drosophila melanogaster	51-55
11342144-3	2001	However, annexin 2 was shown to be associated with chromaffin granules in the presence of EGTA.	Egtazic Acid	90-94	annexin A2	Homo sapiens	9-18
11157497-3	2001	Calcium-dependent binding of annexin II to RAW264.7 macrophages was shown using flow cytometry and Western blot analysis of EGTA eluates.	Egtazic Acid	124-128	annexin A2	Homo sapiens	29-39
11160856-4	2001	The maximal effect of YC-1 was more pronounced than that of the NO donor DEA/NO (approximately 20-fold increase in cGMP accumulation) and markedly diminished in the presence of L-N(G)-nitroarginine, EGTA, or oxyhemoglobin.	Egtazic Acid	199-203	RNA binding motif single stranded interacting protein 1	Homo sapiens	22-26
11036077-4	2001	Here we report that CD146 engagement by its specific monoclonal antibody in human umbilical vein endothelial cells induces a Ca(2+) influx that is sensitive to thapsigargin and EGTA treatment, indicating that CD146 engagement initiates a store-operated calcium mobilization.	Egtazic Acid	177-181	melanoma cell adhesion molecule	Homo sapiens	20-25
11145657-6	2001	The decrease in T cell adhesion and L-selectin expression seems to be dependent on intracellular calcium increase and tyrosine kinase activation, because these effects could be reversed by preincubating salicylate-treated T cells with EGTA, genistein, or tyrphostin.	Egtazic Acid	235-239	selectin L	Homo sapiens	36-46
11036077-4	2001	Here we report that CD146 engagement by its specific monoclonal antibody in human umbilical vein endothelial cells induces a Ca(2+) influx that is sensitive to thapsigargin and EGTA treatment, indicating that CD146 engagement initiates a store-operated calcium mobilization.	Egtazic Acid	177-181	melanoma cell adhesion molecule	Homo sapiens	209-214
12050821-0	2001	Effects of Cyclosporine A and Highly Expressed Bcl-2 on Apoptosis of HL-60 Cells Induced by EGTA.	Egtazic Acid	92-96	BCL2 apoptosis regulator	Homo sapiens	47-52
12050821-1	2001	Effects of mitochondrial permeability transition pore-specific inhibitor cyclosporine A (CsA) and highly expressed Bcl-2 on the apoptosis of HL-60 cells induced by EGTA were studied.	Egtazic Acid	164-168	BCL2 apoptosis regulator	Homo sapiens	115-120
12050821-2	2001	Detection of apoptotic peak by flow cytometry, fluorescent microscope observation of chromatin condensation with double staining of PI and Hoechst33342 and DNA ladder analysis all demonstrated that CsA obviously enhanced the apoptosis of HL-60 cells induced by EGTA, while highly expressed Bcl-2 completely blocked it.	Egtazic Acid	261-265	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	198-201
11118021-10	2000	The intracellular calcium chelator (EGTA/AM) further increased ERK activation by native and mildly modified LDL (P &lt; 0.05).	Egtazic Acid	36-40	Eph receptor B1	Rattus norvegicus	63-66
11123943-5	2000	Limited proteolysis of calcineurin in the presence of EGTA, shows that, when the low affinity sites of calcineurin B are not occupied, the calmodulin-binding domain is completely protected against proteolytic attack.	Egtazic Acid	54-58	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	103-116
11123943-5	2000	Limited proteolysis of calcineurin in the presence of EGTA, shows that, when the low affinity sites of calcineurin B are not occupied, the calmodulin-binding domain is completely protected against proteolytic attack.	Egtazic Acid	54-58	calmodulin 1	Homo sapiens	139-149
11121582-15	2000	However, CaM does inhibit CKII phosphorylation of recombinant apyrase and this inhibition can be blocked by 5 mM EGTA.	Egtazic Acid	113-117	calmodulin 1	Homo sapiens	9-12
11121582-15	2000	However, CaM does inhibit CKII phosphorylation of recombinant apyrase and this inhibition can be blocked by 5 mM EGTA.	Egtazic Acid	113-117	casein kinase 2 alpha 1	Homo sapiens	26-30
10995757-5	2000	The inhibition depends on the presence of calmodulin, occurs at basal cellular levels of Ca(2+), and is eliminated by EGTA.	Egtazic Acid	118-122	calmodulin 1	Homo sapiens	42-52
11104682-7	2000	Furthermore, mobilization of calcium by A23187 and thapsigargin blocked the TNFalpha-mediated induction of RGS16, which was reversed by EGTA and by the immunosuppressants FK506 and cyclosporin A, suggesting that the calcineurin/NF-AT (nuclear factor of activated T cells) pathway may repress the up-regulation process.	Egtazic Acid	136-140	tumor necrosis factor	Homo sapiens	76-84
11104682-7	2000	Furthermore, mobilization of calcium by A23187 and thapsigargin blocked the TNFalpha-mediated induction of RGS16, which was reversed by EGTA and by the immunosuppressants FK506 and cyclosporin A, suggesting that the calcineurin/NF-AT (nuclear factor of activated T cells) pathway may repress the up-regulation process.	Egtazic Acid	136-140	regulator of G protein signaling 16	Homo sapiens	107-112
11156388-8	2000	This hydrolysis is inhibited by EGTA, and the calpain inhibitor I, N-acetyl-leu-leu-norleucinal, but not by several caspases inhibitors, suggesting that BARD1 is hydrolyzed by the calcium-dependent cysteine proteases, calpains.	Egtazic Acid	32-36	BRCA1 associated RING domain 1	Homo sapiens	153-158
12578667-1	2000	The results showed that VP-16 could induced the apoptosis of HL-60 cells and transient increase of intracellular calcium concentration; EGTA [ethylene glycol-bis(2-aminoethyl)-N,N,N",N"-tetraacetic acid], that could combine the extracellular calcium, did not prevent the apoptosis of HL-60 cells.	Egtazic Acid	136-140	host cell factor C1	Homo sapiens	24-29
11062058-4	2000	Physical interactions between the RyR and calcineurin were found in the CSMF in the presence of added 100 microM Ca(2+); however, the interactions were interrupted in the presence of 20 mM EGTA, 1 microM rapamycin or 1 microM FK506, suggesting that the interaction is Ca(2+)-dependent, and is mediated by FKBP12.6.	Egtazic Acid	189-193	ryanodine receptor 2	Rattus norvegicus	34-37
11078432-4	2000	The sustained increase of cytosolic and nuclear Ca2+ by ET-1 in both EEC preparations was completely blocked by the calcium chelator ethylene glycol-bis (beta-aminoethylether)-N,N,N",N"-tetra-acetic acid (EGTA) but was insensitive to the L-type Ca2+ channel blocker, nifedipine.	Egtazic Acid	205-209	endothelin 1	Homo sapiens	56-60
11053220-6	2000	Histamine markedly enhanced the phosphorylation of ERK-1 and ERK-2 by a mechanism that was also enhanced by EGTA and significantly attenuated by procaterol and PD 098059.	Egtazic Acid	108-112	mitogen-activated protein kinase 3	Bos taurus	51-56
11053220-6	2000	Histamine markedly enhanced the phosphorylation of ERK-1 and ERK-2 by a mechanism that was also enhanced by EGTA and significantly attenuated by procaterol and PD 098059.	Egtazic Acid	108-112	mitogen-activated protein kinase 1	Bos taurus	61-66
11206712-1	2000	Avene spa water (ASW) inhibits the histamine release induced in mast cells by substance P; the inhibition is reversed by EDTA and by EGTA.	Egtazic Acid	133-137	surfactant protein A2	Homo sapiens	6-9
11041547-5	2000	When the cells were cultured without Ca2+ (no Ca2+ added, 1 mM EGTA), an oscillatory [Ca2+]i increase of amplitude and short duration (12-35 s) was produced by 11 mM glucose, and the oscillation was inhibited by ruthenium red.	Egtazic Acid	63-67	carbonic anhydrase 2	Homo sapiens	37-40
11033358-1	2000	Pretreatment of Arabidopsis thaliana suspension cells with impermeant calcium chelator EGTA inhibited the ABA-induced RAB18 gene expression.	Egtazic Acid	87-91	RAB GTPASE HOMOLOG B18	Arabidopsis thaliana	118-123
10996851-3	2000	Both ERK and cPLA(2) phosphorylation in response to thapsigargin were inhibited by PD 98059, a specific inhibitor of MAP kinase kinase of the ERK group (MEK), and EGTA.	Egtazic Acid	163-167	mitogen-activated protein kinase 1	Homo sapiens	5-8
11035961-5	2000	PDPc was eluted with 50 mM Tris buffer (pH 7.5) containing 5 mM MgCl(2), 0.5 mM dithiothreitol, and 1 mM EGTA.	Egtazic Acid	105-109	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	0-4
11027542-3	2000	In this study, we show that crosslinking FcalphaR triggers the release of Ca(2+) from an intracellular store that was unchanged by the addition of extracellular EGTA.	Egtazic Acid	161-165	Fc alpha receptor	Homo sapiens	41-49
10996851-3	2000	Both ERK and cPLA(2) phosphorylation in response to thapsigargin were inhibited by PD 98059, a specific inhibitor of MAP kinase kinase of the ERK group (MEK), and EGTA.	Egtazic Acid	163-167	phospholipase A2 group IVA	Homo sapiens	13-20
10919988-4	2000	With low ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and K(+) internal solutions, both ET-1 and histamine induced a sustained depolarization from approximately -40 to -20 mV.	Egtazic Acid	9-73	endothelin 1	Homo sapiens	115-119
10925306-7	2000	EGTA suppressed TGF-beta1- or H2O2-induced IL-6 expression, and ionomycin increased IL-6 expression, with simultaneously modulating AP-1 activity in the same pattern.	Egtazic Acid	0-4	transforming growth factor beta 1	Homo sapiens	16-25
10925306-7	2000	EGTA suppressed TGF-beta1- or H2O2-induced IL-6 expression, and ionomycin increased IL-6 expression, with simultaneously modulating AP-1 activity in the same pattern.	Egtazic Acid	0-4	interleukin 6	Homo sapiens	43-47
10925306-9	2000	In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in TGF-beta1-induced IL-6 expression.	Egtazic Acid	76-80	transforming growth factor beta 1	Homo sapiens	13-22
10925306-9	2000	In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in TGF-beta1-induced IL-6 expression.	Egtazic Acid	76-80	transforming growth factor beta 1	Homo sapiens	126-135
10925306-9	2000	In addition, TGF-beta1 or H2O2 increased MAPK activity which was reduced by EGTA and NAC, suggesting that MAPK is involved in TGF-beta1-induced IL-6 expression.	Egtazic Acid	76-80	interleukin 6	Homo sapiens	144-148
11020377-5	2000	Intracellular perfusion with a Ca2+ free solution containing 10 mM EGTA abolished most of the CCE responses of both non-injected and rTRP4-expressing oocytes.	Egtazic Acid	67-71	transient receptor potential cation channel, subfamily C, member 4	Rattus norvegicus	133-138
10919988-4	2000	With low ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and K(+) internal solutions, both ET-1 and histamine induced a sustained depolarization from approximately -40 to -20 mV.	Egtazic Acid	75-79	endothelin 1	Homo sapiens	115-119
10938296-4	2000	In whole-cell patch-clamp recordings from human embryonic kidney (HEK) 293 cells transiently transfected with recombinant NMDA receptors, we found that addition of calcium chelators such as EGTA shifted the glutamate dose-response curve to the right, from an EC(50) for NR1A/NR2A of 8 microM in 1.8 mM Ca(2+) to approximately 24 microM in a solution containing nominal 0 Ca(2+)/5 mM EGTA and further to approximately 80 microM in 20 mM EGTA.	Egtazic Acid	190-194	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	275-279
10913299-4	2000	PH1 was found to self-associate, and calmodulin or Ca(2+)-chelating agents such as ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) could effectively prevent this oligomerization.	Egtazic Acid	83-152	calmodulin 2	Mus musculus	37-47
10913299-6	2000	Since calmodulin inhibited syntrophin oligomerization in the presence or absence of Ca(2+), Ca(2+) binding to syntrophin is responsible for the inhibition by EGTA of syntrophin oligomerization.	Egtazic Acid	158-162	calmodulin 2	Mus musculus	6-16
10948078-2	2000	Bradykinin enhanced prostacyclin release from endothelial cells time-dependently, but pretreatment with EGTA H-7 or HOE 140 inhibited bradykinin-induced prostacyclin release.	Egtazic Acid	104-108	kininogen 1	Homo sapiens	134-144
10948078-9	2000	Pretreatment with EGTA had effects similar to pretreatment with cycloheximide in the case of cPLA(2) and PGHS-1 but did not affect PGHS-2.	Egtazic Acid	18-22	phospholipase A2 group IVA	Homo sapiens	93-100
10948078-9	2000	Pretreatment with EGTA had effects similar to pretreatment with cycloheximide in the case of cPLA(2) and PGHS-1 but did not affect PGHS-2.	Egtazic Acid	18-22	prostaglandin-endoperoxide synthase 1	Homo sapiens	105-111
10800947-8	2000	Glutamate-dependent iNOS expression was concentration-dependent and was blocked by EGTA and by the inhibitors of nuclear factor kappaB (NF-kappaB) activation pyrrolidine dithiocarbamate and MG132.	Egtazic Acid	83-87	nitric oxide synthase 2	Rattus norvegicus	20-24
10884560-4	2000	When the pipette solutions were filled with high EGTA (10 mM), the YC-1-induced stimulatory effect on I(K(Ca)) was abolished.	Egtazic Acid	49-53	glutathione S-transferase alpha 1	Rattus norvegicus	67-71
10783394-6	2000	TNF-mediated increases in K(+) and Cl(-) currents were each inhibited by intracellular Ca(2+) chelation (5 mm EGTA), ATP depletion (4 units/ml apyrase), and the protein kinase C (PKC) inhibitors chelerythrine (10 micrometer) or PKC 19-36 peptide (1 micrometer).	Egtazic Acid	110-114	tumor necrosis factor-like	Rattus norvegicus	0-3
10892870-16	2000	Western blot analysis of the cytoskeletal protein vimentin (56 kDa) revealed a distinct breakdown product of 48 kDa in ionomycin-treated lenses that was not present when Ca2+ was chelated with EGTA.	Egtazic Acid	193-197	vimentin	Homo sapiens	50-58
10886551-7	2000	PTH secretion from the remaining parathyroid gland was followed in response to EGTA-induced hypocalcemia.	Egtazic Acid	79-83	parathyroid hormone	Rattus norvegicus	0-3
10838184-9	2000	Contact with thrombin-treated ECV304 cells thus induced the exposure of PS on Jurkat cells and, as Jurkat cells were unable to adhere to thrombin-treated ECV304 cells in the presence of EGTA, the adhesion of the two cell types may involve a Ca(2+) bridge between PS on both cell surfaces.	Egtazic Acid	186-190	coagulation factor II, thrombin	Homo sapiens	13-21
11956559-11	2000	Furthermore, GABA markedly increased the HAM of P(4) on guinea pig spermatozoa, which was mediated obviously by the influx of extracellular Ca(2+) because the GABA-induced AR could be prevented by EGTA.	Egtazic Acid	197-201	solute carrier family 10 member 4	Homo sapiens	48-52
10818233-5	2000	We demonstrated the capacity of tagged CalB to bind Ca(2+) using the (45)Ca(2+) overlay assay and showed that its mobility on SDS-PAGE is dependent on Ca(2+)/EGTA pretreatment.	Egtazic Acid	158-162	calbindin 1	Homo sapiens	39-43
10804019-9	2000	The presence of EGTA in the culture media reduced slightly the VDR mRNA levels under basal condition but this was not modified in the presence of increasing levels of HCTZ.	Egtazic Acid	16-20	vitamin D receptor	Homo sapiens	63-66
10804019-12	2000	In contrast, HCTZ induced a dose-dependent increase in cFOS levels (p &lt; 0.002 by ANOVA), a situation prevented by incubation with EGTA.	Egtazic Acid	133-137	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-59
10875237-7	2000	In Ca2+-free/EGTA-supplemented medium, basal luciferase reporter-gene activity and endogenous P450(scc) messenger RNA accumulation in granulosa cells declined to 34 +/- 12% and 78 +/- 12%, respectively, of corresponding values in control (unstimulated Ca2+-containing) cultures.	Egtazic Acid	13-17	serpin family B member 3	Homo sapiens	94-103
10839987-4	2000	UV irradiation resulted in partial, EGTA-resistant cross-linking of annexin II to the polysomes.	Egtazic Acid	36-40	annexin A2	Homo sapiens	68-78
10749891-9	2000	Likewise, p27 in preadipocyte extracts is a substrate for purified calpain; this proteolytic action was inhibited by heat inactivation, EGTA, or ALLN.	Egtazic Acid	136-140	interferon alpha inducible protein 27	Homo sapiens	10-13
10844127-7	2000	In C6 cells expressing cloned human 5-HT(1B) receptors, zolmitriptan-induced increases in I(K) were prevented by the calcium chelator, EGTA (5 mM) when included in the patch pipette (maximum increase -3.3+/-4.2%, n=4, P=NS).	Egtazic Acid	135-139	5-hydroxytryptamine receptor 1B	Homo sapiens	36-43
10814513-6	2000	Third, the treatment with EGTA, a Ca(2+) chelator that is known to inhibit the fusion of C2C12 myoblasts, reversibly inhibited the up-regulation of SPARC gene expression.	Egtazic Acid	26-30	secreted acidic cysteine rich glycoprotein	Mus musculus	148-153
10804019-6	2000	Reducing extracellular Ca2+ concentration with 0.5 mM EDTA or 0.5 mM ethylene glycol-bis(beta-amino ethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) only partly prevented the inhibitory effect of the diuretic on OC secretion (maximal effect, -22.5+/-6.9%), suggesting that thiazide-dependent Ca2+ influx is not sufficient to elicit the inhibition of OC secretion.	Egtazic Acid	69-139	bone gamma-carboxyglutamate protein	Homo sapiens	210-212
10731718-4	2000	The addition of calmodulin or S100 to the mixture of calponin and desmin caused the removal of calponin from the desmin filaments and inhibited bundle formation in the presence of Ca(2+), but not in the presence of EGTA.	Egtazic Acid	215-219	desmin	Homo sapiens	66-72
10777622-4	2000	It contained an endogenously bound CaM, which was essential in folding and stabilizing this mutant enzyme, and retained 60% of L-citrulline formation in 5 mM EGTA.	Egtazic Acid	158-162	calmodulin 1	Homo sapiens	35-38
10753604-6	2000	Treatment of Ramos with EGTA and BAPTA to block changes in cytoplasmic Ca(2+) likewise prevented CD20-induced apoptosis.	Egtazic Acid	24-28	keratin 20	Homo sapiens	97-101
10725701-7	2000	Addition of EGTA/Mg2+ revealed that effectors from vvM2/IL-4-infected mice primarily lyse targets by a Ca2+-independent Fas/FasL pathway.	Egtazic Acid	12-16	interleukin 4	Mus musculus	51-60
10692402-6	2000	In addition, S1179D eNOS did show an increased resistance to inactivation by EGTA compared with wild type eNOS.	Egtazic Acid	77-81	nitric oxide synthase 3	Bos taurus	20-24
10634928-5	2000	External Ca(2+) chelation (EGTA 4 mM) or administration of Ca(2+) channel inhibitors gadolinium 50 microM or nickel 500 microM inhibited insulin-induced PI 3-kinase activation by 85, 50 and 50%, respectively, whereas 200 microM verapamil was without effect.	Egtazic Acid	27-31	WAP four-disulfide core domain 15B	Rattus norvegicus	153-157
10700554-8	2000	Both ERK1/2 diphosphorylation and the apoptotic-like cell death were largely prevented by MK-801, a specific NMDA receptor (a subtype receptor of glutamate) antagonist, or the elimination of extracellular Ca(2+) with EGTA.	Egtazic Acid	217-221	mitogen activated protein kinase 3	Rattus norvegicus	5-11
10679094-8	2000	The sustained calcium flux returned to baseline levels after addition of EGTA, suggesting that the expression of the CD45 S/A mutant may have prevented deactivation of plasma membrane calcium channels.	Egtazic Acid	73-77	protein tyrosine phosphatase receptor type C	Homo sapiens	117-121
10673387-7	2000	Pretreatment with EGTA to eliminate extracellular Ca(2+), or with APV, an NMDA receptor antagonist, to inhibit Ca(2+) influx through the NMDA receptor, attenuated the activation of ERK.	Egtazic Acid	18-22	Eph receptor B1	Rattus norvegicus	181-184
10617151-9	2000	Activators of PAR-2 caused a sharp peak in [Ca2+]i followed by a sustained plateau; [Ca2+]i returned to baseline levels upon treatment with ethylene-glycol tetraacetic acid (EGTA).	Egtazic Acid	140-172	F2R like trypsin receptor 1	Rattus norvegicus	14-19
10617151-9	2000	Activators of PAR-2 caused a sharp peak in [Ca2+]i followed by a sustained plateau; [Ca2+]i returned to baseline levels upon treatment with ethylene-glycol tetraacetic acid (EGTA).	Egtazic Acid	174-178	F2R like trypsin receptor 1	Rattus norvegicus	14-19
10556769-2	1999	GS4 stimulated insulin release from HIT-T15, MIN6 and RINm5F beta-cells and from islets in the absence of any other stimulus, and GS4-stimulated insulin secretion was inhibited in the presence of 1 mM EGTA.	Egtazic Acid	201-205	speedy/RINGO cell cycle regulator family member A	Rattus norvegicus	130-133
10617106-5	2000	Consistent with previous reports, glutamate, both acute and chronic, causes CGN death that is characterized by cell swelling, sensitivity to MK-801 and EGTA, and only small numbers of apoptotic nuclei.	Egtazic Acid	152-156	cingulin	Homo sapiens	76-79
10574989-9	1999	Consistent with this, we found that increased sensitivity of yeast to EGTA in the high Na(+) medium is due to inhibition of SMF1- and SMF2-mediated metal ion transport by uncoupled Na(+) pathway.	Egtazic Acid	70-74	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	124-128
10574989-9	1999	Consistent with this, we found that increased sensitivity of yeast to EGTA in the high Na(+) medium is due to inhibition of SMF1- and SMF2-mediated metal ion transport by uncoupled Na(+) pathway.	Egtazic Acid	70-74	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	134-138
10564655-5	1999	Furthermore, experiments with this mutant revealed that EGTA induced lateral Trp(156)/Val(157)-independent homodimerization of E-cadherin.	Egtazic Acid	56-60	cadherin 1	Homo sapiens	127-137
10548553-8	1999	However, results obtained with the reverse construct and other chimeras indicated that these regions are not solely responsible for the differences in EGTA- and pH-sensitivity of NRAMP1 and NRAMP2.	Egtazic Acid	151-155	solute carrier family 11 member 1	Homo sapiens	179-185
10548553-8	1999	However, results obtained with the reverse construct and other chimeras indicated that these regions are not solely responsible for the differences in EGTA- and pH-sensitivity of NRAMP1 and NRAMP2.	Egtazic Acid	151-155	solute carrier family 11 member 2	Homo sapiens	190-196
10600485-5	1999	Reduction of the extracellular Ca(2+) concentration by EGTA abolished the anti-apoptotic effect, suggesting that annexin V favors Ca(2+) influx and that Ca(2+) acts as an inhibitor rather than an activator of apoptosis in CEM T cells.	Egtazic Acid	55-59	annexin A5	Homo sapiens	113-122
10619653-5	1999	Depolarization by potassium or veratridine also induced GTPCH expression, which was abolished by EGTA.	Egtazic Acid	97-101	NGG1 interacting factor 3 like 1	Bos taurus	56-61
10479156-7	1999	In the presence of a nominal calcium buffer or EGTA, amphotericin B-induced IL-1beta expression is attenuated.	Egtazic Acid	47-51	interleukin 1 beta	Homo sapiens	76-84
10531365-7	1999	Cell fractionation studies showed that S100A6 was present in the microsomal fraction in the presence of Ca(2+) and was released from this fraction by the addition of EGTA/EDTA but not by Triton X-100.	Egtazic Acid	166-170	S100 calcium binding protein A6	Homo sapiens	39-45
10529472-5	1999	Activation of AP-1 by carbachol was dependent on calcium, as it was inhibited by treatment with the extracellular calcium chelator EGTA, the intracellular calcium chelator BAPTA-AM, and the calcium/calmodulin kinase II inhibitor KN62.	Egtazic Acid	131-135	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-18
10512759-8	1999	By contrast, calcium-reducing agents TMB-8 and EGTA together with A23187 inhibited the DIF-1-induced activation of Akt/PKB.	Egtazic Acid	47-51	AKT serine/threonine kinase 1	Homo sapiens	115-122
10561565-2	1999	Tightly bound annexin VI is virtually completely solubilized only after treatment with a buffer supplemented both with EGTA and detergent.	Egtazic Acid	119-123	annexin A6	Oryctolagus cuniculus	14-24
10582659-3	1999	The depletion of extracellular Ca2+ by EGTA reduced the PGD2-induced IL-6 synthesis.	Egtazic Acid	39-43	interleukin 6	Mus musculus	69-73
10412048-5	1999	The phosphorylation of p38 MAP kinase by bFGF was suppressed by TMB-8, an inhibitor of intracellular Ca(2+) mobilization, or the depletion of extracellular Ca(2+) with EGTA.	Egtazic Acid	168-172	mitogen-activated protein kinase 14	Mus musculus	23-26
10412048-5	1999	The phosphorylation of p38 MAP kinase by bFGF was suppressed by TMB-8, an inhibitor of intracellular Ca(2+) mobilization, or the depletion of extracellular Ca(2+) with EGTA.	Egtazic Acid	168-172	fibroblast growth factor 2	Mus musculus	41-45
10535262-5	1999	The induction of TNF alpha was not found in EDTA-added blood but was found in the EGTA-added them treated with CS, though different levels were showed.	Egtazic Acid	82-86	tumor necrosis factor	Homo sapiens	17-26
10455189-9	1999	Increasing cytosolic Ca(2+) with ionomycin stimulated HEF1 phosphorylation and preventing any calcitonin-induced change in cytosolic calcium by a combination of BAPTA and extracellular EGTA completely blocked the calcitonin-induced tyrosine phosphorylation of HEF1.	Egtazic Acid	185-189	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	260-264
10448007-6	1999	The cytotoxicity of the CB-derived CD4(+) CTL clones was inhibited by EGTA but not by anti-Fas ligand mAb, suggesting that this cytotoxicity was mediated by perforin/granzyme B.	Egtazic Acid	70-74	CD4 molecule	Homo sapiens	35-38
10438495-2	1999	We now report evidence that these biometals also mediate the deposition of Abeta amyloid in Alzheimer"s disease, since the solubilization of Abeta from post-mortem brain tissue was significantly increased by the presence of chelators, EGTA, N,N,N",N"-tetrakis(2-pyridyl-methyl) ethylene diamine, and bathocuproine.	Egtazic Acid	235-239	amyloid beta precursor protein	Homo sapiens	75-80
10438495-2	1999	We now report evidence that these biometals also mediate the deposition of Abeta amyloid in Alzheimer"s disease, since the solubilization of Abeta from post-mortem brain tissue was significantly increased by the presence of chelators, EGTA, N,N,N",N"-tetrakis(2-pyridyl-methyl) ethylene diamine, and bathocuproine.	Egtazic Acid	235-239	amyloid beta precursor protein	Homo sapiens	141-146
10406836-11	1999	The pressure-induced expression of c-fos was not inhibited by nitrendipine (10 micromol/L), a calcium-free Krebs" solution containing EGTA (1 to 2 mmol/L), calphostin C (0.1 micromol/L), or cytochalasin D (0.4 micromol/L) but was inhibited by genistein (30 micromol/L).	Egtazic Acid	134-138	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-40
10433854-9	1999	Furthermore, both, acidification of the reaction buffer (from pH 7.4 to 6.4) and the addition of a metal chelator, EGTA (2 mM) decreased ECE-1 activity by nearly 60%.	Egtazic Acid	115-119	endothelin converting enzyme 1	Homo sapiens	137-142
10425463-8	1999	PTH concentrations showed a similar rise during EGTA-induced hypocalcaemia in control and diabetic rats compared with saline-infused rats, whereas 1,25(OH)(2)D(3) concentrations were unchanged in both groups.	Egtazic Acid	48-52	parathyroid hormone	Rattus norvegicus	0-3
10381264-5	1999	This increase was clearly inhibited by the presence of EGTA (10(-3) M), A23187 (10(-6) M), trifluoperazine (10(-5) M), staurosporine (10(-7) M), or genistein (10(-5) M) with 6-h-culture, although the beta-actin mRNA expression was not altered by the reagents.	Egtazic Acid	55-59	actin, beta	Rattus norvegicus	200-210
10424425-4	1999	The apoptosis is rapid, Fas ligand independent and completely inhibited by the calcium chelator EGTA, suggesting a fractricidal ADCC reaction and implying that NK cells are not resistant to lysis when used as target cells.	Egtazic Acid	96-100	Fas ligand	Homo sapiens	24-34
10485320-3	1999	Liver cytosolic phosphatase activity with three phosphoaminoacids was significantly increased in the presence of anti-regucalcin antibody (100 and 200 ng/ml) in the enzyme reaction mixture with calcium chloride (0.1 mM) or EGTA (1.0 mM).	Egtazic Acid	223-227	regucalcin	Rattus norvegicus	118-128
10398759-4	1999	The association of CK II with the cardiac SR, even after EGTA extraction at alkaline pH, is demonstrated using antibodies against CK II.	Egtazic Acid	57-61	casein kinase 2 alpha 1	Homo sapiens	19-24
10362499-2	1999	The shifts in the mobility of p56(Lck) induced by ionomycin could be blocked by preincubation of the cells with EGTA, demonstrating the requirement for extracellular calcium in this response.	Egtazic Acid	112-116	cyclin dependent kinase like 2	Homo sapiens	30-33
10362499-2	1999	The shifts in the mobility of p56(Lck) induced by ionomycin could be blocked by preincubation of the cells with EGTA, demonstrating the requirement for extracellular calcium in this response.	Egtazic Acid	112-116	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	34-37
10336529-6	1999	Both intracellular Ca2+ chelation (using BAPTA/AM) and extracellular Ca2+ depletion (using EGTA) significantly inhibited PE-induced c-fos expression by alpha1A and alpha1B receptors.	Egtazic Acid	91-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-137
10320738-2	1999	Potassium fluoride (KF), 440 mM trimethylamine chloride and exclusion of bovine serum albumin (BSA) decreased the activity of the enzyme, while ethylene glycol-bis (beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) and the potassium salts of aspartate, gluconate, methylsulfate and monobasic phosphate increased its activity.	Egtazic Acid	216-220	albumin	Homo sapiens	80-93
10376803-8	1999	An EGTA-resistant membrane-bound annexin II was present in lung type II cells.	Egtazic Acid	3-7	annexin A2	Bos taurus	33-43
10347087-8	1999	Phosphorylation of STAT1 and STAT3 was strongly inhibited by HOE642 (Na+/H+ exchanger inhibitor) and BAPTA-AM (intracellular calcium chelator), but not by gadolinium (stretch-activated ion channel inhibitor), EGTA (extracellular Ca2+ chelator), or KN62 (Ca2+/calmodulin kinase II inhibitor).	Egtazic Acid	209-213	signal transducer and activator of transcription 1	Rattus norvegicus	19-24
10347087-8	1999	Phosphorylation of STAT1 and STAT3 was strongly inhibited by HOE642 (Na+/H+ exchanger inhibitor) and BAPTA-AM (intracellular calcium chelator), but not by gadolinium (stretch-activated ion channel inhibitor), EGTA (extracellular Ca2+ chelator), or KN62 (Ca2+/calmodulin kinase II inhibitor).	Egtazic Acid	209-213	signal transducer and activator of transcription 3	Rattus norvegicus	29-34
10215917-6	1999	Release of tPA induced by BDNF depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	109-177	plasminogen activator, tissue	Mus musculus	11-14
10215917-6	1999	Release of tPA induced by BDNF depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	109-177	brain derived neurotrophic factor	Mus musculus	26-30
10215917-6	1999	Release of tPA induced by BDNF depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	179-183	plasminogen activator, tissue	Mus musculus	11-14
10215917-6	1999	Release of tPA induced by BDNF depends on extracellular Ca2+ since it is markedly reduced in the presence of ethylene glycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	179-183	brain derived neurotrophic factor	Mus musculus	26-30
10217274-9	1999	On the other hand, treatment of neurons for 48 h with the intracellular Ca2+ chelator BAPTA-AM as well as partial chelation of extracellular Ca2+ with EGTA caused an up-regulation in NR1 and GBP expression.	Egtazic Acid	151-155	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	183-186
10217274-9	1999	On the other hand, treatment of neurons for 48 h with the intracellular Ca2+ chelator BAPTA-AM as well as partial chelation of extracellular Ca2+ with EGTA caused an up-regulation in NR1 and GBP expression.	Egtazic Acid	151-155	transmembrane protein 132A	Homo sapiens	191-194
10217261-5	1999	EGTA induced DNA laddering and an increase in caspase-3-like, but not calpain, activity.	Egtazic Acid	0-4	caspase 3	Homo sapiens	46-55
10217274-10	1999	The enhanced expression of NR1 in neurons treated for 48 h with either ethanol or EGTA was correlated with increases in the activity of NMDA receptors demonstrated as a doubling of the NMDA-stimulated rise in intracellular free Ca2+ concentration.	Egtazic Acid	82-86	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	27-30
10217261-10	1999	We conclude that the EGTA treatment lowered intracellular Ca2+ and elicited caspase-3-like protease activity, which led to apoptosis.	Egtazic Acid	21-25	caspase 3	Homo sapiens	76-85
10217274-11	1999	The effects of chronic administration of EGTA on both NR1 expression as well as NMDA receptor function were probably related to an acute inhibition by EGTA of NMDA-induced Ca2+ influx into neurons.	Egtazic Acid	41-45	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	54-57
10217274-11	1999	The effects of chronic administration of EGTA on both NR1 expression as well as NMDA receptor function were probably related to an acute inhibition by EGTA of NMDA-induced Ca2+ influx into neurons.	Egtazic Acid	151-155	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	54-57
10217266-2	1999	We used western blot analysis to demonstrate that the proapoptotic protein Bax translocated from the cytosolic to the mitochondrial fraction in SH-SY5Y human neuroblastoma cells undergoing staurosporine- or EGTA-mediated apoptosis.	Egtazic Acid	207-211	BCL2 associated X, apoptosis regulator	Homo sapiens	75-78
10098511-6	1999	In accordance, omission of Ca2+ from the extracellular medium by specific Ca2+ chelators, EDTA or EGTA (4 mmol/liter each), markedly diminished the hCG-stimulated P production.	Egtazic Acid	98-102	hypertrichosis 2 (generalised, congenital)	Homo sapiens	148-151
10217266-4	1999	In EGTA-treated cells, increased levels of mitochondrial Bax were seen at 4 h, consistent with a slower onset of apoptosis in EGTA versus staurosporine treatments.	Egtazic Acid	3-7	BCL2 associated X, apoptosis regulator	Homo sapiens	57-60
10098511-16	1999	Stimulation of hCG significantly elevated (2.1 +/- 0.3-fold) the SF-1 mRNA level, which was further augmented in the presence of Ca2+, whereas EGTA and verapamil completely abolished the increase caused by Ca2+.	Egtazic Acid	143-147	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18
10098511-16	1999	Stimulation of hCG significantly elevated (2.1 +/- 0.3-fold) the SF-1 mRNA level, which was further augmented in the presence of Ca2+, whereas EGTA and verapamil completely abolished the increase caused by Ca2+.	Egtazic Acid	143-147	splicing factor 1	Mus musculus	65-69
10452119-6	1999	When the [Ca2+]i store was depleted with ionomycin in the presence of egtazic acid (EGTA), the increase in pHi induced by thrombin was inhibited.	Egtazic Acid	70-82	glucose-6-phosphate isomerase	Oryctolagus cuniculus	107-110
10231343-9	1999	In both groups a rapid and similar increase in p-Ca2+ took place 10 min after discontinuing EGTA (P &lt; 0.	Egtazic Acid	92-96	carbonic anhydrase 2	Rattus norvegicus	49-52
10452119-6	1999	When the [Ca2+]i store was depleted with ionomycin in the presence of egtazic acid (EGTA), the increase in pHi induced by thrombin was inhibited.	Egtazic Acid	70-82	prothrombin	Oryctolagus cuniculus	122-130
10452119-6	1999	When the [Ca2+]i store was depleted with ionomycin in the presence of egtazic acid (EGTA), the increase in pHi induced by thrombin was inhibited.	Egtazic Acid	84-88	glucose-6-phosphate isomerase	Oryctolagus cuniculus	107-110
10452119-6	1999	When the [Ca2+]i store was depleted with ionomycin in the presence of egtazic acid (EGTA), the increase in pHi induced by thrombin was inhibited.	Egtazic Acid	84-88	prothrombin	Oryctolagus cuniculus	122-130
10217527-10	1999	Removal of Ca2+ by the addition of EGTA or application of Ca2+-channel blockers, verapamil, diltiazem, and Ni2+, inhibited the BK-induced IP accumulation and Ca2+ mobilization, indicating that Ca2+ influx was required for the BK-induced responses.	Egtazic Acid	35-39	kininogen 1	Canis lupus familiaris	127-129
10192172-6	1999	The effects of UTP were abolished in Ca2+-deficient buffer supplemented with EGTA.	Egtazic Acid	77-81	UTP4 small subunit processome component	Homo sapiens	15-18
10082949-7	1999	In the presence of Mg2+ and EGTA, the N-terminal, regulatory Ca2+-binding sites of TnC are unoccupied.	Egtazic Acid	28-32	tenascin C	Homo sapiens	83-86
9988766-7	1999	When EGTA was added shortly after [Ca2+]i increase, the cPLA2-GFP returned to the cytosol, without liberating AA.	Egtazic Acid	5-9	cytosolic phospholipase A2	Cricetulus griseus	56-61
10080140-11	1999	The increase in PLA2 activity was attenuated if cells were incubated in Ca2+-depleted medium containing EGTA (4 mM).	Egtazic Acid	104-108	phospholipase A2 group IB	Rattus norvegicus	16-20
10080143-4	1999	The increase of NO release as well as the reduced acid response were attenuated by pretreatment with L-NAME or coapplication of EGTA, and the latter inhibited the luminal increase of Ca2+.	Egtazic Acid	128-132	carbonic anhydrase 2	Rattus norvegicus	183-186
10193806-6	1999	Then by a brief infusion of EGTA plasma Ca2+ was reduced from 1.26+/-0.02 to 0.86+/-0.02 mmol/l, P&lt;0.001.	Egtazic Acid	28-32	carbonic anhydrase 2	Rattus norvegicus	40-43
10193806-7	1999	Despite there being no PTH in the circulation plasma Ca2+ increased significantly to 0.97+/-0.02 mmol/l already 10 min after discontinuation of the EGTA infusion, P&lt;0.04, and plasma Ca2+ was normalized within another 2 h. II.	Egtazic Acid	148-152	carbonic anhydrase 2	Rattus norvegicus	53-56
10193806-9	1999	Despite there being no PTH and no kidneys present plasma Ca2+ increased significantly already 10 min after discontinuation of EGTA to 0.96+/-0.02 mmol/l, P&lt;0.02.	Egtazic Acid	126-130	carbonic anhydrase 2	Rattus norvegicus	57-60
10193806-14	1999	Then plasma Ca2+ was further reduced to 0.79+/-0.03 mmol/l by EGTA.	Egtazic Acid	62-66	carbonic anhydrase 2	Rattus norvegicus	12-15
10193806-15	1999	Ten minutes after discontinuing EGTA plasma Ca2+ increased to 0.91+/-0.02 mmol/l, P&lt;0.03 and 60 min later plasma Ca2+ reached the level of the control PTX rats.	Egtazic Acid	32-36	carbonic anhydrase 2	Rattus norvegicus	44-47
10193806-16	1999	Normal rats with intact parathyroid glands had an exactly similar response of plasma Ca2+ to EGTA as that of 24 h PTX rats, but at significantly higher levels of plasma Ca2+ with a fall from 1.28+/-0.01 to 0.96+/-0.03 mmol/l and again a significant increase of plasma Ca2+ to 1.13+/-0.03 (P&lt;0.001) 10 min after discontinuation of EGTA.	Egtazic Acid	93-97	carbonic anhydrase 2	Rattus norvegicus	85-88
9950687-9	1999	Antibodies against Sec22b/ERS-24 inhibit ER-Golgi transport only when they are added before the EGTA-sensitive stage.	Egtazic Acid	96-100	SEC22 homolog B, vesicle trafficking protein	Homo sapiens	19-25
10048787-7	1999	The appearance of IFN-gamma-mediated Ca2+-signals in the presence of EGTA indicates that IFN-gamma stimulates Ca2+ release from intracellular stores.	Egtazic Acid	69-73	interferon gamma	Homo sapiens	18-27
10048787-7	1999	The appearance of IFN-gamma-mediated Ca2+-signals in the presence of EGTA indicates that IFN-gamma stimulates Ca2+ release from intracellular stores.	Egtazic Acid	69-73	interferon gamma	Homo sapiens	89-98
9925747-4	1999	The [Ca2+]i signal was required for the transcriptional activation of two immediate early genes (IEGs), c-fos and c-jun, since blocking Ca2+ influx with Gd3+ or EGTA reduced IEG transcription, while augmenting Ca2+ influx increased IEG transcription.	Egtazic Acid	161-165	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-109
9925747-4	1999	The [Ca2+]i signal was required for the transcriptional activation of two immediate early genes (IEGs), c-fos and c-jun, since blocking Ca2+ influx with Gd3+ or EGTA reduced IEG transcription, while augmenting Ca2+ influx increased IEG transcription.	Egtazic Acid	161-165	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	114-119
9950687-9	1999	Antibodies against Sec22b/ERS-24 inhibit ER-Golgi transport only when they are added before the EGTA-sensitive stage.	Egtazic Acid	96-100	SEC22 homolog B, vesicle trafficking protein	Homo sapiens	26-32
9990296-4	1999	MARCKS phosphorylation was inhibited by staurosporine, bis-indolylmaleimide (a PKC-specific inhibitor), Go6983 (inhibits all isoforms except PKC mu), and a peptide from the calmodulin-binding domain of MARCKS, but was unaffected by EGTA or Go6976 (inhibits cPKCs and PKC mu).	Egtazic Acid	232-236	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
9878749-10	1999	Exposure of cells to calcium-free medium supplemented with EGTA produced only a transient rise in MyD116 mRNA levels peaking after 6 h of recovery.	Egtazic Acid	59-63	protein phosphatase 1, regulatory subunit 15A	Rattus norvegicus	98-104
9886846-5	1999	In addition, GnRH-A-stimulated GnRHR-Luc activity was inhibited by preventing external Ca2+ influx with the external Ca2+ chelator EGTA or the Ca2+ ion channel antagonist, D600.	Egtazic Acid	131-135	gonadotropin releasing hormone 1	Mus musculus	13-17
9886938-3	1999	For the second method, addition of extracellular EGTA at a concentration shown to deplete intracellular Ca2+ pools also increased ERK activity.	Egtazic Acid	49-53	carbonic anhydrase 2	Rattus norvegicus	104-107
9886938-3	1999	For the second method, addition of extracellular EGTA at a concentration shown to deplete intracellular Ca2+ pools also increased ERK activity.	Egtazic Acid	49-53	Eph receptor B1	Rattus norvegicus	130-133
9886938-6	1999	Furthermore, depletion of intracellular Ca2+ with EGTA caused inactivation of protein phosphatase 2A and protein tyrosine phosphatases.	Egtazic Acid	50-54	carbonic anhydrase 2	Rattus norvegicus	40-43
9882439-6	1999	The enzymatic activity of purified GPI-PLD, which was depleted of divalent cations by pretreatment with EDTA, EGTA, or 1, 10-phenanthroline, could be completely restored with Zn2+ (and partially with Co2+), which indicates that Ca2+ can be removed from the protein without affecting its enzymatic activity.	Egtazic Acid	110-114	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	35-42
10191961-5	1999	Consistent with these findings, genistein (200 microM) or removal of extracellular Ca2+ (EGTA 1 mM), inhibited Ca(2+)-dependent agonist-induced beta-glucuronidase release by similar extents (about 50%).	Egtazic Acid	89-93	glucuronidase beta	Homo sapiens	144-162
9932728-6	1999	However, the thapsigargin- and cyclopiazonic acid-induced cPLA2 activation was completely inhibited by the tyrosine kinase inhibitor, erbstatin, and Ca2+ chelator, EGTA.	Egtazic Acid	164-168	phospholipase A2 group IVA	Homo sapiens	58-63
10072102-6	1999	The calcium-chelating agent EGTA inhibited the PACAP-induced loss of chloride, indicating the need for extracellular calcium ions.	Egtazic Acid	28-32	adenylate cyclase activating polypeptide 1	Homo sapiens	47-52
9886846-5	1999	In addition, GnRH-A-stimulated GnRHR-Luc activity was inhibited by preventing external Ca2+ influx with the external Ca2+ chelator EGTA or the Ca2+ ion channel antagonist, D600.	Egtazic Acid	131-135	gonadotropin releasing hormone receptor	Rattus norvegicus	31-36
10050072-11	1999	Removal of extracellular Ca2+ and addition of 0.1 or 2 mM EGTA completely inhibited ET-1-stimulated PLD activity.	Egtazic Acid	58-62	endothelin 1	Rattus norvegicus	84-88
10231391-6	1999	During native polyacrylamide gel electrophoresis, SCF migrated more rapidly in the presence of Ca2+ than in the presence of Mg2+ or EGTA.	Egtazic Acid	132-136	supercoiling factor	Drosophila melanogaster	50-53
9892847-11	1999	The calcium chelator EGTA, but not the calcium ionophore A23187, blocked the GH-releasing activity of thymulin in AP cells.	Egtazic Acid	21-25	gonadotropin releasing hormone receptor	Rattus norvegicus	77-79
10477087-4	1999	Ethyleneglycotetraacetic acid (EGTA) chelation of extracellular Ca2+ resulted in an approximately 70% attenuation of thrombin-stimulated increase in [Ca2+]cyt.	Egtazic Acid	31-35	coagulation factor II, thrombin	Homo sapiens	117-125
10458519-6	1999	Treatment with calcium-free Krebs + EGTA (2 x 10(-3) mol/l) + sodium nitroprusside (10(-5) mol/l) or calcium-free Krebs significantly decreased basal tone and abolished ANP-response.	Egtazic Acid	36-40	natriuretic peptide A	Rattus norvegicus	169-172
9922166-6	1998	Likewise, addition of EGTA to Ca2+-bound or Tb3+-bound MBP-C causes a decrease in intrinsic tryptophan fluorescence with biphasic kinetics consisting of a burst phase with a rate constant greater than 1 s(-1), followed by a slow phase with a single-exponential rate constant of 0.065 s(-1).	Egtazic Acid	22-26	mannose binding lectin 2	Rattus norvegicus	55-60
9922147-5	1998	For example, binding of either CaM or B12QCaM to the MLCK-I peptide is observed even in the presence of EGTA, whereas binding of CaM to the enzyme requires Ca2+.	Egtazic Acid	104-108	calmodulin 1	Homo sapiens	31-34
9882395-11	1998	Immunoreactive PTH concentrations in serum of rats administered EGTA were determined by SPA and by a commercially available PTH immunoassay.	Egtazic Acid	64-68	parathyroid hormone	Rattus norvegicus	15-18
9922147-5	1998	For example, binding of either CaM or B12QCaM to the MLCK-I peptide is observed even in the presence of EGTA, whereas binding of CaM to the enzyme requires Ca2+.	Egtazic Acid	104-108	myosin light chain kinase	Homo sapiens	53-59
9922147-5	1998	For example, binding of either CaM or B12QCaM to the MLCK-I peptide is observed even in the presence of EGTA, whereas binding of CaM to the enzyme requires Ca2+.	Egtazic Acid	104-108	calmodulin 1	Homo sapiens	42-45
9827702-3	1998	Nuclear protein kinase activity was significantly decreased in the presence of EGTA (1.0 mM), trifluoperazine (TFP; 20 microM), dibucaine (10(-4) M), or staurosporine (10(-7) M), indicating that Ca2+-dependent protein kinases are present in the nuclei.	Egtazic Acid	79-83	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	8-22
9827702-5	1998	Hepatectomy-increased nuclear protein kinase activity was significantly decreased in the presence of EGTA (1.0 mM), TFP (20 microM), or staurosporine (10(-7) M) in the enzyme reaction mixture.	Egtazic Acid	101-105	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	30-44
9882395-12	1998	There was a good correlation between the two assays with significant increases in serum immunoreactive PTH concentrations at 15 and 30 min after EGTA injection and a rapid decrease to baseline values by 60 min.	Egtazic Acid	145-149	parathyroid hormone	Homo sapiens	103-106
9826630-6	1998	The data suggest that binding of Ca2+ to the gelsolin-F-actin complex is the rate-limiting step for F-actin severing by gelsolin; this Ca2+ binding event is a committed step that results in a Ca2+ ion bound at a high-affinity, EGTA-resistant site.	Egtazic Acid	227-231	gelsolin	Homo sapiens	120-128
9875242-4	1998	Chelation of calcium by EGTA significantly and specifically inhibited the apoptosis potentiated by mitochondria as well as the increase of caspase-3-like activity.	Egtazic Acid	24-28	caspase-3-like	Rattus norvegicus	139-153
9892044-5	1998	RESULTS: We show that EGTA (5 mM) prevented TNF-alpha mRNA expression and TNF-alpha secretion in antigen-stimulated cells.	Egtazic Acid	22-26	tumor necrosis factor	Rattus norvegicus	44-53
9826630-6	1998	The data suggest that binding of Ca2+ to the gelsolin-F-actin complex is the rate-limiting step for F-actin severing by gelsolin; this Ca2+ binding event is a committed step that results in a Ca2+ ion bound at a high-affinity, EGTA-resistant site.	Egtazic Acid	227-231	gelsolin	Homo sapiens	45-53
9892044-5	1998	RESULTS: We show that EGTA (5 mM) prevented TNF-alpha mRNA expression and TNF-alpha secretion in antigen-stimulated cells.	Egtazic Acid	22-26	tumor necrosis factor	Rattus norvegicus	74-83
9879718-7	1998	In C6 cells expressing either cloned h 5-HT1B or h 5-HT1D receptors, sumatriptan-induced increases in IK were prevented by the calcium chelator EGTA (5 mM) when included in the patch pipette (maximum increase 0.57+/-0.6%, n=3, P=NS and -2.8+/-1.6%, n=5, P=NS, respectively).	Egtazic Acid	144-148	5-hydroxytryptamine receptor 1B	Homo sapiens	39-45
10221596-7	1998	Calcitonin levels decreased following EGTA-induced hypocalcemia and were undetectable after thyroparathyroidectomy.	Egtazic Acid	38-42	calcitonin-related polypeptide alpha	Rattus norvegicus	0-10
9811717-6	1998	However, treatment with hypotonic shock or EGTA transiently increased transepithelial permeability, enhancing gene transfer with the vector applied to the mucosal surfaces of KGF-stimulated epithelia.	Egtazic Acid	43-47	fibroblast growth factor 7	Homo sapiens	175-178
9879718-7	1998	In C6 cells expressing either cloned h 5-HT1B or h 5-HT1D receptors, sumatriptan-induced increases in IK were prevented by the calcium chelator EGTA (5 mM) when included in the patch pipette (maximum increase 0.57+/-0.6%, n=3, P=NS and -2.8+/-1.6%, n=5, P=NS, respectively).	Egtazic Acid	144-148	5-hydroxytryptamine receptor 1D	Homo sapiens	51-57
9863648-5	1998	However, in the presence of 5 mM EGTA or SKF 96365, an inhibitor of receptor mediated Ca2+ influx (1.0-3.0 x 10(-5) M) ET-1-induced Ca2+ increases were inhibited in normal, but not in PTX-treated cells.	Egtazic Acid	33-37	endothelin 1	Homo sapiens	119-123
9756500-3	1998	Contraction and Src kinase activity were inhibited in cells incubated in Ca2+-free medium containing 2 mM EGTA and in cells preincubated with herbimycin A, a Src kinase inhibitor.	Egtazic Acid	106-110	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	16-19
9780210-5	1998	Addition of EGTA before thapsigargin inhibited the induction of IL-8 production.	Egtazic Acid	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
9780210-6	1998	Experiments in which EGTA was added at various times after thapsigargin treatment indicated that a sustained Ca2+ influx was required for maximum IL-8 production.	Egtazic Acid	21-25	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
9826060-12	1998	Chelation of extracellular calcium with 3 mM EGTA inhibited the NKA-induced PGE2 release by 81% but was without effect on basal and NKA-stimulated IP3 production.	Egtazic Acid	45-49	tachykinin precursor 1	Homo sapiens	64-67
9777254-10	1998	SP-induced responses were also blocked by several signal transduction-related compounds, such as tetrodotoxin, EGTA, and U73122, a selective phospholipase C inhibitor.	Egtazic Acid	111-115	tachykinin 1	Mus musculus	0-2
9755245-5	1998	In HTC cells, the volume-dependent Cl- current response (-46 +/- 5 pA/pF) was inhibited by down-regulation of PKC (100 nmol/L phorbol 12-myristate 13-acetate for 18 hours [PMA]; -1.97 +/- 1.5 pA/pF), chelation of cytosolic Ca2+ (2 mmol/L EGTA; -5.3 +/- 4.0 pA/pF), depletion of cytosolic adenosine triphosphate (ATP) (3 U/mL apyrase; -12.58 +/- 1.	Egtazic Acid	238-242	protein kinase C, gamma	Rattus norvegicus	110-113
9765268-1	1998	On T cells the leukocyte integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) can be induced to bind its ligand intercellular adhesion molecule 1 (ICAM-1) (CD54) either by increasing the affinity of the receptor with Mg2+ and EGTA or by receptor clustering following activation with phorbol ester.	Egtazic Acid	243-247	integrin subunit alpha L	Homo sapiens	75-80
9765268-1	1998	On T cells the leukocyte integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) can be induced to bind its ligand intercellular adhesion molecule 1 (ICAM-1) (CD54) either by increasing the affinity of the receptor with Mg2+ and EGTA or by receptor clustering following activation with phorbol ester.	Egtazic Acid	243-247	integrin subunit alpha L	Homo sapiens	83-88
9765268-1	1998	On T cells the leukocyte integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) can be induced to bind its ligand intercellular adhesion molecule 1 (ICAM-1) (CD54) either by increasing the affinity of the receptor with Mg2+ and EGTA or by receptor clustering following activation with phorbol ester.	Egtazic Acid	243-247	integrin subunit beta 2	Homo sapiens	89-93
9765268-1	1998	On T cells the leukocyte integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) can be induced to bind its ligand intercellular adhesion molecule 1 (ICAM-1) (CD54) either by increasing the affinity of the receptor with Mg2+ and EGTA or by receptor clustering following activation with phorbol ester.	Egtazic Acid	243-247	intercellular adhesion molecule 1	Homo sapiens	129-162
9765268-1	1998	On T cells the leukocyte integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) can be induced to bind its ligand intercellular adhesion molecule 1 (ICAM-1) (CD54) either by increasing the affinity of the receptor with Mg2+ and EGTA or by receptor clustering following activation with phorbol ester.	Egtazic Acid	243-247	intercellular adhesion molecule 1	Homo sapiens	164-170
9765268-1	1998	On T cells the leukocyte integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18) can be induced to bind its ligand intercellular adhesion molecule 1 (ICAM-1) (CD54) either by increasing the affinity of the receptor with Mg2+ and EGTA or by receptor clustering following activation with phorbol ester.	Egtazic Acid	243-247	intercellular adhesion molecule 1	Homo sapiens	173-177
9751483-5	1998	To examine further the interactions, partially purified IDE-MCP complex was treated with EDTA or EGTA, and activity was measured in the absence and presence of various divalent cations (Ca2+, Mn2+, Co2+, and Zn2+) and insulin.	Egtazic Acid	97-101	insulin degrading enzyme	Homo sapiens	56-59
9751483-8	1998	EGTA treatment had a lesser effect on MCP activity, but abolished insulin inhibition of activity.	Egtazic Acid	0-4	insulin	Homo sapiens	66-73
9748529-7	1998	The second procedure, immersion of cells in calcium free medium supplemented with EGTA, caused only a transient increase in gadd153 mRNA levels, peaking at 6 h of recovery, indicating that a depletion of ER calcium stores in the absence of an increase in cytoplasmic calcium activity is sufficient to activate neuronal gadd153 expression.	Egtazic Acid	82-86	DNA-damage inducible transcript 3	Rattus norvegicus	124-131
9791894-4	1998	The cloned gene product exhibits 60.3% amino acid identity to the S. cerevisiae PMR1 gene product and complemented the growth defect of a S. cerevisiae pmr1 null mutant in the EGTA-containing medium.	Egtazic Acid	176-180	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	80-84
9791894-4	1998	The cloned gene product exhibits 60.3% amino acid identity to the S. cerevisiae PMR1 gene product and complemented the growth defect of a S. cerevisiae pmr1 null mutant in the EGTA-containing medium.	Egtazic Acid	176-180	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	152-156
9748529-7	1998	The second procedure, immersion of cells in calcium free medium supplemented with EGTA, caused only a transient increase in gadd153 mRNA levels, peaking at 6 h of recovery, indicating that a depletion of ER calcium stores in the absence of an increase in cytoplasmic calcium activity is sufficient to activate neuronal gadd153 expression.	Egtazic Acid	82-86	DNA-damage inducible transcript 3	Rattus norvegicus	319-326
9614208-4	1998	The action of TGF-beta2 could be abolished by cycloheximide or EGTA, suggesting the requirement of a newly synthesized protein and extracellular Ca2+.	Egtazic Acid	63-67	transforming growth factor, beta 2	Rattus norvegicus	14-23
9701561-0	1998	Alpha-SNAP but not gamma-SNAP is required for ER-Golgi transport after vesicle budding and the Rab1-requiring step but before the EGTA-sensitive step.	Egtazic Acid	130-134	NSF attachment protein alpha	Homo sapiens	0-10
9701561-10	1998	It has been shown previously that EGTA blocks ER-Golgi transport at a step after vesicle docking but before fusion and we show here that alpha-SNAP acts before the step that is blocked by EGTA.	Egtazic Acid	34-38	NSF attachment protein alpha	Homo sapiens	137-147
9701561-10	1998	It has been shown previously that EGTA blocks ER-Golgi transport at a step after vesicle docking but before fusion and we show here that alpha-SNAP acts before the step that is blocked by EGTA.	Egtazic Acid	188-192	NSF attachment protein alpha	Homo sapiens	137-147
9642151-6	1998	However, in EC preincubated for 24 hours in Ca2+-free medium, elevated baseline phosphorylation was minimally activated by EGTA (200 microM) such that cyclic strain stimulated ERK1/2 in the presence or absence of BHQ.	Egtazic Acid	123-127	mitogen-activated protein kinase 3	Bos taurus	176-182
9730877-12	1998	Release of NO*, which was measured by chemiluminescence analysis in parallel experiments, affected the gating behavior of KCa channels in the presence of SOD and ethyleneglycol-bis-(beta-aminoethyl ether)- N,N"-tetraacetic acid (EGTA) by reducing the mean closed times and increasing the number and duration of short open events.	Egtazic Acid	229-233	superoxide dismutase 1	Homo sapiens	154-157
9724531-5	1998	The binding of SP-A to vesicles and the aggregation of vesicles are rapid, and the aggregation is rapidly reversed by EGTA; i.e., both the forward and reverse aggregation reactions are complete in about 1 min.	Egtazic Acid	118-122	surfactant protein A1	Homo sapiens	15-19
9688645-10	1998	The L-type Ca2+ channel blocker diltiazem (10 microM) and the Ca2+ chelator EGTA (1 mM) significantly inhibited BB-stimulated secretin release by 64% and 59%, respectively, and inhibited PACAP-stimulated release by 75% and 55%, respectively.	Egtazic Acid	76-80	adenylate cyclase activating polypeptide 1	Rattus norvegicus	187-192
9658102-4	1998	A significant coenzyme activity was detected in the CaM bound to gp160 even in the presence of a Ca2+ chelater, EGTA.	Egtazic Acid	112-116	calmodulin 3	Homo sapiens	52-55
9658102-4	1998	A significant coenzyme activity was detected in the CaM bound to gp160 even in the presence of a Ca2+ chelater, EGTA.	Egtazic Acid	112-116	glutamyl aminopeptidase	Homo sapiens	65-70
9746221-7	1998	DNA fragmentation in the liver nuclei obtained from CCl4-administered rats was significantly decreased by the presence of EGTA (2 mM) in the reaction mixture, suggesting that the endogenous calcium activates nuclear DNA fragmentation.	Egtazic Acid	122-126	C-C motif chemokine ligand 4	Rattus norvegicus	52-56
9642151-5	1998	Chelation of normal extracellular Ca2+ (1.8 mM) medium with EGTA (3 mM) acutely stimulated baseline phosphorylation and activation of ERK1/2, thereby obscuring any strain-induced activation of ERK1/2.	Egtazic Acid	60-64	mitogen-activated protein kinase 3	Bos taurus	134-140
9642151-5	1998	Chelation of normal extracellular Ca2+ (1.8 mM) medium with EGTA (3 mM) acutely stimulated baseline phosphorylation and activation of ERK1/2, thereby obscuring any strain-induced activation of ERK1/2.	Egtazic Acid	60-64	mitogen-activated protein kinase 3	Bos taurus	193-199
9572479-8	1998	PGHS-2 mRNA and protein induction by 5-HT was also abolished by chelation of Ca2+ ions by EGTA, suggesting involvement of Ca2+-dependent enzymes.	Egtazic Acid	90-94	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	0-6
9572479-9	1998	In contrast, egr-1 mRNA expression was superinduced in the presence of EGTA.	Egtazic Acid	71-75	early growth response 1	Rattus norvegicus	13-18
9612371-11	1998	Two of the proteins dephosphorylated by treatment of cells with NO or EGTA were identified as the focal adhesion proteins, cortactin and paxillin.	Egtazic Acid	70-74	cortactin	Rattus norvegicus	123-132
9579793-4	1998	When recordings were made using EGTA-containing patch pipettes, nociceptin caused inhibition in all 30 supraoptic nucleus neurons tested, and burst-firing was not seen.	Egtazic Acid	32-36	prepronociceptin	Rattus norvegicus	64-74
9606972-2	1998	Here we report that both cobalt and the calcium chelator EGTA, inhibitors of calcium uptake, as well as cyclosporin A and FK-506, specific inhibitors of calcineurin function, abolished fibroblast growth factor (FGF)-induced expression of cyclins A and E, but not cyclin D1.	Egtazic Acid	57-61	cyclin A2	Homo sapiens	238-253
9606972-2	1998	Here we report that both cobalt and the calcium chelator EGTA, inhibitors of calcium uptake, as well as cyclosporin A and FK-506, specific inhibitors of calcineurin function, abolished fibroblast growth factor (FGF)-induced expression of cyclins A and E, but not cyclin D1.	Egtazic Acid	57-61	cyclin D1	Homo sapiens	263-272
9560440-5	1998	At a concentration of 20 microM OAG (1-oleoyl-2-acetyl-sn-glycerol), a PKC activator, inhibited ICCh at 0.5 mM [EGTA]i but far less at 2 mM [EGTA]i (18% and 81% of control, respectively).	Egtazic Acid	112-116	Prkca	Cavia porcellus	71-74
9525478-7	1998	Chelation of [Ca++]i with Quin-2 and EGTA reduced both basal (unstimulated) expression of the 15/7 epitope and basal adhesion of granulocytic HL60 cells to fibronectin.	Egtazic Acid	37-41	fibronectin 1	Homo sapiens	156-167
9574534-4	1998	The critical role of CD95/CD95-L interaction was supported by complete inhibition in the presence of the antagonist CD95 mAb ZB4 and by blocking CD95-L synthesis and surface expression by cycloheximide, cyclosporin A, EGTA, or cytochalasin B.	Egtazic Acid	218-222	Fas cell surface death receptor	Homo sapiens	21-25
9574534-4	1998	The critical role of CD95/CD95-L interaction was supported by complete inhibition in the presence of the antagonist CD95 mAb ZB4 and by blocking CD95-L synthesis and surface expression by cycloheximide, cyclosporin A, EGTA, or cytochalasin B.	Egtazic Acid	218-222	Fas ligand	Homo sapiens	26-32
9574534-4	1998	The critical role of CD95/CD95-L interaction was supported by complete inhibition in the presence of the antagonist CD95 mAb ZB4 and by blocking CD95-L synthesis and surface expression by cycloheximide, cyclosporin A, EGTA, or cytochalasin B.	Egtazic Acid	218-222	Fas cell surface death receptor	Homo sapiens	26-30
9574534-4	1998	The critical role of CD95/CD95-L interaction was supported by complete inhibition in the presence of the antagonist CD95 mAb ZB4 and by blocking CD95-L synthesis and surface expression by cycloheximide, cyclosporin A, EGTA, or cytochalasin B.	Egtazic Acid	218-222	Fas cell surface death receptor	Homo sapiens	26-30
9538253-4	1998	KCl-induced tyrosine phosphorylation of p130(cas) was not observed in EGTA-containing medium, suggesting that it was due to Ca2+ influx into the cells.	Egtazic Acid	70-74	RB transcriptional corepressor like 2	Rattus norvegicus	40-44
9518518-8	1998	The calcium specific chelator EGTA prevented IL-10 protein production induced by the electric pulse in a dose-dependent manner.	Egtazic Acid	30-34	interleukin 10	Homo sapiens	45-50
9556135-5	1998	The depletion of extracellular Ca2+ by EGTA reduced the PGE2-induced IL-6 secretion.	Egtazic Acid	39-43	interleukin 6	Mus musculus	69-73
9510205-3	1998	We report here that mannan-coated MBL-sensitized erythrocytes are lysed via the lectin pathway in human serum-Mg-EGTA.	Egtazic Acid	113-117	mannose binding lectin 2	Homo sapiens	34-37
9685212-4	1998	In the presence of EGTA or Ni2+, the stimulatory effect of TRH on [Ca2+]i and alpha-MSH secretion was totally suppressed.	Egtazic Acid	19-23	TRH	Canis lupus familiaris	59-62
9482252-4	1998	Addition of the calcium chelator, ethylene glycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) restored the normal level of NF-66 and partially that of the Hsc 70.	Egtazic Acid	34-103	internexin neuronal intermediate filament protein alpha	Homo sapiens	140-145
9488694-9	1998	Data derived from sequential incubations with combinations of suramin, EGTA, and PCV were consistent with the presence of two distinct pools of apoE on the HepG2 ECM, one releasable with suramin and EGTA and the other releasable with lipids.	Egtazic Acid	199-203	apolipoprotein E	Homo sapiens	144-148
9480878-0	1998	Maturation and secretion of rat hepatic lipase is inhibited by alpha1B-adrenergic stimulation through changes in Ca2+ homoeostasis: thapsigargin and EGTA both mimic the effect of adrenaline.	Egtazic Acid	149-153	lipase C, hepatic type	Rattus norvegicus	32-46
9473230-4	1998	The apoptotic effects of these MoAbs can be inhibited by chelation of extracellular or intracellular Ca2+ by EGTA or Bapta AM, indicating that anti-CD20-mediated apoptosis may be related to changes in Ca2+ concentration.	Egtazic Acid	109-113	keratin 20	Homo sapiens	148-152
9567200-6	1998	The spontaneous cleavage of DNA-containing fibres in step (4) of the above procedure can be blocked by the chelating agents EGTA and EDTA, by the caspase-2,3,7 inhibitor N-acetyl-Asp-Glu-Val-Asp-aldehyde, and by the caspase-1,4,5 inhibitors N-acetyl-Tyr-Val-Ala-Asp-aldehyde and N-acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone.	Egtazic Acid	124-128	caspase a	Danio rerio	216-225
9462701-4	1998	Intracellular pre-loading of the InsP3 receptor antagonist heparin or the Ca2+ chelator EGTA clearly prevented both inward and outward currents, indicating that activation of Ca2+-dependent Cl- and K+ currents underlies the inward and the outward currents.	Egtazic Acid	88-92	carbonic anhydrase 2	Rattus norvegicus	74-77
9462701-4	1998	Intracellular pre-loading of the InsP3 receptor antagonist heparin or the Ca2+ chelator EGTA clearly prevented both inward and outward currents, indicating that activation of Ca2+-dependent Cl- and K+ currents underlies the inward and the outward currents.	Egtazic Acid	88-92	carbonic anhydrase 2	Rattus norvegicus	175-178
9555982-5	1998	Store dependent Ca2+ influx, directly measured on readdition of calcium to Tg-treated cells incubated in EGTA buffer, was significantly enhanced in IFN-gamma-treated cells.	Egtazic Acid	105-109	interferon gamma	Homo sapiens	148-157
9488694-7	1998	EDTA or EGTA also displaced 35% of the apoE, suggesting a Ca2+-dependent association.	Egtazic Acid	8-12	apolipoprotein E	Homo sapiens	39-43
9464995-5	1998	The response to ATP was completely abolished by removal of extracellular Ca2+ with EGTA.	Egtazic Acid	83-87	carbonic anhydrase 2	Rattus norvegicus	73-76
9482252-4	1998	Addition of the calcium chelator, ethylene glycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) restored the normal level of NF-66 and partially that of the Hsc 70.	Egtazic Acid	34-103	heat shock protein family A (Hsp70) member 8	Homo sapiens	172-178
9482252-4	1998	Addition of the calcium chelator, ethylene glycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) restored the normal level of NF-66 and partially that of the Hsc 70.	Egtazic Acid	105-109	internexin neuronal intermediate filament protein alpha	Homo sapiens	140-145
9482252-4	1998	Addition of the calcium chelator, ethylene glycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA) restored the normal level of NF-66 and partially that of the Hsc 70.	Egtazic Acid	105-109	heat shock protein family A (Hsp70) member 8	Homo sapiens	172-178
9468542-6	1998	Depletion of intracellular calcium stores by EGTA pretreatment has no effect on growth factor-induced Akt activation but completely abolishes p70(S6k) stimulation.	Egtazic Acid	45-49	ubiquitin associated and SH3 domain containing B	Homo sapiens	142-145
11243144-3	1998	RESULTS: PTA1 McAb induced human platelet aggregation in vitro, which could be completely inhibited by EGTA and PGI2.	Egtazic Acid	103-107	CD226 molecule	Homo sapiens	9-13
10374640-6	1998	Depletion of intracellular Ca2+ store with ionomycin in the presence of EGTA, no increment in pHi was observed, the basal value of pHi was even more acidic, this response of pHi to thrombin was rehabilitated after refilling of intracellular Ca2+ store with extracellular Ca2+ 1 mmol.L-1.	Egtazic Acid	72-76	coagulation factor II, thrombin	Homo sapiens	181-189
9468542-6	1998	Depletion of intracellular calcium stores by EGTA pretreatment has no effect on growth factor-induced Akt activation but completely abolishes p70(S6k) stimulation.	Egtazic Acid	45-49	ribosomal protein S6 kinase B1	Homo sapiens	146-149
9463429-8	1998	When increases in intracellular Ca2+ were buffered by intracellular injection of ethylene glycol bis(beta-aminoethyl)ether-N,N,N",N"-tetraacetic acid, the sIPSP suppression seen after a single spontaneous or evoked burst discharge was abolished.	Egtazic Acid	81-149	carbonic anhydrase 2	Homo sapiens	32-35
9487547-6	1998	EGTA treatment resulted in an increased permeability (P = 18.69 +/- 1.09 x 10(-6) cm sec-1).	Egtazic Acid	0-4	secretory blood group 1, pseudogene	Homo sapiens	85-90
9426289-7	1998	Prior depletion of intracellular Ca2+ stores with thapsigargin, an inhibitor of Ca2+-ATPase of the endoplasmic reticulum, abolished the ET-1-induced Ca2+ transient, whereas removal of extracellular Ca2+ with EGTA eliminated the sustained rise.	Egtazic Acid	208-212	endothelin 1	Homo sapiens	136-140
9473603-3	1998	The increases in [Ca2+]i caused by the depolarizing agents almost completely disappeared in the absence of Ca2+ (0 mM Ca2+ with 1 mM EGTA).	Egtazic Acid	133-137	carbonic anhydrase 2	Rattus norvegicus	18-21
9781350-5	1998	Triton X-100 extracts of hepatocyte membrane ghosts were chromatographed on Lf-agarose, and a 45 kDa polypeptide (p45) was eluted by EGTA.	Egtazic Acid	133-137	caspase 1	Rattus norvegicus	114-117
9502114-3	1998	The VIP-induced c-fos expression was inhibited in the presence of EGTA, or the L-type Ca2+ channel blockers verapamil and nifedipine.	Egtazic Acid	66-70	vasoactive intestinal peptide	Rattus norvegicus	4-7
9502114-3	1998	The VIP-induced c-fos expression was inhibited in the presence of EGTA, or the L-type Ca2+ channel blockers verapamil and nifedipine.	Egtazic Acid	66-70	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
10076799-3	1998	CAM4, in contrast, interacts with CaM in a Ca(2+)-independent manner, interacting with both holoCaM and EGTA-treated CaM to a similar extent.	Egtazic Acid	104-108	calmodulin	Bos taurus	34-37
9487547-8	1998	This effect was prevented by EGTA treatment (P = 15.11 +/- 2.57 x 10(-6) cm sec-1).	Egtazic Acid	29-33	secretory blood group 1, pseudogene	Homo sapiens	76-81
9390185-5	1997	Notably, the differential accessibility of the nucleotide binding domain at acidic and basic pH cannot be rationalized in terms of the ATPase E1/E2 conformational equilibrium since a shift of the ATPase toward the E1 (plus Ca2+) or E2 (plus EGTA) did not affect the accessibility of fluorescein-labeled ATPase to the quencher.	Egtazic Acid	241-245	dynein axonemal heavy chain 8	Homo sapiens	196-202
9390185-5	1997	Notably, the differential accessibility of the nucleotide binding domain at acidic and basic pH cannot be rationalized in terms of the ATPase E1/E2 conformational equilibrium since a shift of the ATPase toward the E1 (plus Ca2+) or E2 (plus EGTA) did not affect the accessibility of fluorescein-labeled ATPase to the quencher.	Egtazic Acid	241-245	dynein axonemal heavy chain 8	Homo sapiens	196-202
9421231-11	1997	Reducing the extracellular calcium concentration with EGTA (microM range) totally inhibited the effect of Glipizide and Glybenclamide on osteocalcin secretion (p &lt; 0.005), which remained at the same levels as controls.	Egtazic Acid	54-58	bone gamma-carboxyglutamate protein	Homo sapiens	137-148
9812342-8	1997	Both EGTA and the protein kinase C inhibitor trifluoperazine, but not the calcium ionophre A23187, were able to reduce significantly the GH response of somatotrophs to histones.	Egtazic Acid	5-9	gonadotropin releasing hormone receptor	Rattus norvegicus	137-139
9382863-12	1997	Antibodies against rbet1 inhibit ER-Golgi transport only when they are added before the EGTA-sensitive stage.	Egtazic Acid	88-92	Bet1 golgi vesicular membrane trafficking protein	Rattus norvegicus	19-24
9382871-7	1997	Upon EGTA-mediated cell dissociation, p205 is internalized with E-cadherin and F-actin as a component of adherens junctions "rings."	Egtazic Acid	5-9	cadherin 1	Bos taurus	64-74
9473140-9	1997	Stimulation with VIP caused transient Ca2+ responses in Ca2+-free physiological saline containing 50 microM EGTA.	Egtazic Acid	108-112	vasoactive intestinal peptide	Bos taurus	17-20
9398641-5	1997	Chelation of extracellular calcium by EGTA, intracellular calcium by BAPTA, AM, and RMCE blockade by SKF 96365 all statistically inhibited the PAF induced increase in surface expression of CD11b (p &lt; 0.05); moreover, SKF 96365 inhibited to a greater extent than EGTA or BAPTA, AM treatment.	Egtazic Acid	38-42	integrin subunit alpha M	Homo sapiens	189-194
9398641-5	1997	Chelation of extracellular calcium by EGTA, intracellular calcium by BAPTA, AM, and RMCE blockade by SKF 96365 all statistically inhibited the PAF induced increase in surface expression of CD11b (p &lt; 0.05); moreover, SKF 96365 inhibited to a greater extent than EGTA or BAPTA, AM treatment.	Egtazic Acid	265-269	integrin subunit alpha M	Homo sapiens	189-194
9360964-7	1997	Nramp2, but not Nramp1, was found to complement hypersensitivity to EGTA of the smf1/smf2 mutant under oxidative stress conditions (methyl viologen).	Egtazic Acid	68-72	solute carrier family 11 member 2	Homo sapiens	0-6
9360964-7	1997	Nramp2, but not Nramp1, was found to complement hypersensitivity to EGTA of the smf1/smf2 mutant under oxidative stress conditions (methyl viologen).	Egtazic Acid	68-72	divalent metal ion transporter SMF1	Saccharomyces cerevisiae S288C	80-84
9360964-7	1997	Nramp2, but not Nramp1, was found to complement hypersensitivity to EGTA of the smf1/smf2 mutant under oxidative stress conditions (methyl viologen).	Egtazic Acid	68-72	divalent metal ion transporter SMF2	Saccharomyces cerevisiae S288C	85-89
9360964-10	1997	Since Mn2+ was the only divalent cation capable of completely suppressing both the EGTA and pH phenotypes, our results suggest that Nramp2 can transport Mn2+ in yeast.	Egtazic Acid	83-87	solute carrier family 11 member 2	Homo sapiens	132-138
9473140-3	1997	In Ca2+ imaging studies, VIP evoked Ca2+ transients in Ca2+-free medium containing 50 microM EGTA.	Egtazic Acid	93-97	vasoactive intestinal peptide	Bos taurus	25-28
9448942-5	1997	The agonist-induced responses were completely blocked by addition of EGTA to chelate external Ca2+ and by addition of the 5-HT3 receptor antagonist tropisetron or the L-type Ca2+ channel blocker nitrendipine.	Egtazic Acid	69-73	carbonic anhydrase 2	Mus musculus	94-97
9359490-4	1997	AK-T cell-mediated killing of P815 tumor cells pre-treated with 2 microg/ml cisplatin or 1 microg/ml etoposide was only partially inhibitable by the Ca2+ chelator EGTA, suggesting that the Ca2+-independent Fas (CD95)/Fas ligand cytolytic pathway of AK-T cells contributes to cytotoxicity.	Egtazic Acid	163-167	Fas (TNF receptor superfamily member 6)	Mus musculus	211-215
9349535-8	1997	Furthermore, chelation of calcium with EGTA or blockade of voltage-dependent calcium channels with nifedipine inhibited agonist-mediated down-regulation of CRF-R1 mRNA levels.	Egtazic Acid	39-43	corticotropin releasing hormone receptor 1	Mus musculus	156-162
9383042-6	1997	Removal of Ca2+ from the perfusion solution combined with the addition of the Ca2+ chelator EGTA (2 mM) completely but reversibly eliminated all oscillations suggesting the fluctuations were dependent on Ca2+ flux across the membrane.	Egtazic Acid	92-96	carbonic anhydrase 2	Homo sapiens	78-81
9383042-6	1997	Removal of Ca2+ from the perfusion solution combined with the addition of the Ca2+ chelator EGTA (2 mM) completely but reversibly eliminated all oscillations suggesting the fluctuations were dependent on Ca2+ flux across the membrane.	Egtazic Acid	92-96	carbonic anhydrase 2	Homo sapiens	78-81
9334390-7	1997	In support of this interpretation, Ca2+-free/EGTA medium induced a greater than 60-fold increase in DARPP-32 phosphorylation and abolished the ability of quinpirole to dephosphorylate DARPP-32.	Egtazic Acid	45-49	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	100-108
9334390-7	1997	In support of this interpretation, Ca2+-free/EGTA medium induced a greater than 60-fold increase in DARPP-32 phosphorylation and abolished the ability of quinpirole to dephosphorylate DARPP-32.	Egtazic Acid	45-49	protein phosphatase 1, regulatory inhibitor subunit 1B	Mus musculus	184-192
9413730-5	1997	Endothelin-1 produced an increase in tension of permeabilized neonatal portal vein in a calcium solution buffered with 10 mM EGTA.	Egtazic Acid	125-129	endothelin 1	Rattus norvegicus	0-12
9359416-6	1997	We show that RPE probably contains two types of PLA2 enzyme, as indicated by the results obtained with different PLA2-active fractions eluted from cation-exchange columns and treated with Ca2+/EGTA, dithiothreitol, p-bromophenacyl bromide or heat.	Egtazic Acid	193-197	LOC104974671	Bos taurus	48-52
9344851-5	1997	The AA activation of mGPDH was completely inhibited by 50 microM EGTA, but could be fully restored by the sequential addition of 100 microM Ca2+.	Egtazic Acid	65-69	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	21-26
9345295-5	1997	Depletion of allergenbound calcium by EGTA treatment lead to a substantial reduction of IgE-binding to Bet v 4, indicating that protein-bound calcium is necessary for the maintenance of IgE-epitopes.	Egtazic Acid	38-42	delta/notch like EGF repeat containing	Homo sapiens	103-106
9392525-7	1997	EGTA also appeared to affect the structure of recoverin independent of its chelation of calcium.	Egtazic Acid	0-4	recoverin	Homo sapiens	46-55
9326243-5	1997	Chelation of extracellular Ca2+ with EGTA partially prevents anti-CD77-induced apoptosis, indicating that this process is probably Ca2+ dependent.	Egtazic Acid	37-41	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	66-70
9399436-6	1997	Treatment of the plant with calcium and EGTA showed the involvement of calcium and, in particular, intracellular calcium in calmodulin gene expression and cellular response.	Egtazic Acid	40-44	calcium-binding protein CP1	Solanum lycopersicum	124-134
9496430-3	1997	This enzyme activity was only inhibited by divalent cation chelators such as EDTA, EGTA and o-phenanthroline (1 mM) and was insensitive to phosphoramidon and captopril (1 microM concentration), specific inhibitors of neutral endopeptidase (EC 3.4.24.11) and angiotensin-converting enzyme (EC 3.4.15.1), respectively.	Egtazic Acid	83-87	angiotensin I converting enzyme	Homo sapiens	258-287
9281306-4	1997	The depletion of extracellular Ca2+ by EGTA suppressed the thrombin-induced IL-6 synthesis.	Egtazic Acid	39-43	coagulation factor II	Mus musculus	59-67
9298970-4	1997	Scatchard analysis of [3H]ryanodine binding performed in the presence of 100 microM EGTA indicates that S100A1 increases the apparent affinity of the receptor for ryanodine (Kd = 191 vs 383 nM in the presence and in the absence of 100 nM S100A1, respectively).	Egtazic Acid	84-88	protein S100-A1	Oryctolagus cuniculus	104-110
9298970-12	1997	S100A1 binding domain 1 binds the ligand in the presence of 1 mM free [Ca2+] or 1 mM EGTA.	Egtazic Acid	85-89	protein S100-A1	Oryctolagus cuniculus	0-6
9335263-4	1997	Moreover, the ionophore-mediated increase in PHF-1 was blocked by EGTA, by the calpain inhibitor calpeptin and by the PKC inhibitor H7, while that evoked by betaA treatment was not inhibited by any of these treatments.	Egtazic Acid	66-70	PHD finger protein 1	Homo sapiens	45-50
9281306-4	1997	The depletion of extracellular Ca2+ by EGTA suppressed the thrombin-induced IL-6 synthesis.	Egtazic Acid	39-43	interleukin 6	Mus musculus	76-80
9292524-6	1997	The results showed that IL-3 was induced by calcium ionophore and that the IL-3 induced by Fc gammaRIII stimulation was blocked by EGTA or FK506, but not by staurosporine (protein kinase C [PKC] inhibitor), indicating the important role of calcium-calcineurin in this system.	Egtazic Acid	131-135	interleukin 3	Mus musculus	24-28
9292524-6	1997	The results showed that IL-3 was induced by calcium ionophore and that the IL-3 induced by Fc gammaRIII stimulation was blocked by EGTA or FK506, but not by staurosporine (protein kinase C [PKC] inhibitor), indicating the important role of calcium-calcineurin in this system.	Egtazic Acid	131-135	interleukin 3	Mus musculus	75-79
9292524-6	1997	The results showed that IL-3 was induced by calcium ionophore and that the IL-3 induced by Fc gammaRIII stimulation was blocked by EGTA or FK506, but not by staurosporine (protein kinase C [PKC] inhibitor), indicating the important role of calcium-calcineurin in this system.	Egtazic Acid	131-135	Fc receptor, IgG, low affinity III	Mus musculus	91-103
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Egtazic Acid	116-120	Fas (TNF receptor superfamily member 6)	Mus musculus	23-27
9325011-1	1997	The authors investigated the dependence on extracellular and intracellular free Ca2+ in the induction of apoptosis and secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) by tumour necrosis factor (TNF) in a rat/mouse T cell hybridoma PC60 R55/R75, using the Ca2+ chelators EGTA and BAPTA/AM, respectively.	Egtazic Acid	293-297	colony stimulating factor 2	Rattus norvegicus	182-188
9376229-3	1997	The depletion of extracellular Ca2+ by EGTA suppressed the bFGF-induced IL-6 synthesis.	Egtazic Acid	39-43	fibroblast growth factor 2	Mus musculus	59-63
9376229-3	1997	The depletion of extracellular Ca2+ by EGTA suppressed the bFGF-induced IL-6 synthesis.	Egtazic Acid	39-43	interleukin 6	Mus musculus	72-76
9387192-1	1997	Prolongation of action potentials upon the addition of various cAMP increasing agents under Ca2+ free-EGTA condition, which was previously suggested to be produced by persistent Na+ influx through Ca2+ channel due to lack of Ca(2+)-mediated inactivation, was examined in isolated myocardial preparations from neonatal and adult guinea-pigs.	Egtazic Acid	102-106	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	92-95
9387192-1	1997	Prolongation of action potentials upon the addition of various cAMP increasing agents under Ca2+ free-EGTA condition, which was previously suggested to be produced by persistent Na+ influx through Ca2+ channel due to lack of Ca(2+)-mediated inactivation, was examined in isolated myocardial preparations from neonatal and adult guinea-pigs.	Egtazic Acid	102-106	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	197-200
9316641-11	1997	All three prostate tumor cell lines were sensitive to killing by TIL and LAK and cell killing was primarily mediated through the Ca(2+)-dependent perforin pathway because it was blocked by the addition of EGTA/MgCl2.	Egtazic Acid	205-209	toll like receptor 1	Homo sapiens	65-68
9261131-5	1997	More directly, ionomycin activated the IRK1 expression in time- and dose-dependent manners, which was abolished by treatment with EGTA.	Egtazic Acid	130-134	potassium inwardly-rectifying channel, subfamily J, member 2	Mus musculus	39-43
9316641-11	1997	All three prostate tumor cell lines were sensitive to killing by TIL and LAK and cell killing was primarily mediated through the Ca(2+)-dependent perforin pathway because it was blocked by the addition of EGTA/MgCl2.	Egtazic Acid	205-209	alpha kinase 1	Homo sapiens	73-76
9316641-13	1997	However, in the presence of EGTA/MgCl2, the addition of CDDP or VP-16 significantly augmented killing of PC-3 and DU145, but not LnCAP, by TIL and LAK, and killing was blocked by neutralizing anti-Fas antibody.	Egtazic Acid	28-32	host cell factor C1	Homo sapiens	56-69
9316641-14	1997	These findings demonstrate that both TIL and LAK exhibit a Fas-L-mediated killing pathway that is revealed once the perforin pathway is blocked by the Ca2+ chelator EGTA/MgCl2.	Egtazic Acid	165-169	toll like receptor 1	Homo sapiens	37-40
9316641-14	1997	These findings demonstrate that both TIL and LAK exhibit a Fas-L-mediated killing pathway that is revealed once the perforin pathway is blocked by the Ca2+ chelator EGTA/MgCl2.	Egtazic Acid	165-169	alpha kinase 1	Homo sapiens	45-48
9316641-14	1997	These findings demonstrate that both TIL and LAK exhibit a Fas-L-mediated killing pathway that is revealed once the perforin pathway is blocked by the Ca2+ chelator EGTA/MgCl2.	Egtazic Acid	165-169	Fas ligand	Homo sapiens	59-64
9242678-9	1997	The calcium chelating agent EGTA inhibited ACTH-induced SAPK activity and the calcium ionophore A23187 induced SAPK activity 3-fold.	Egtazic Acid	28-32	proopiomelanocortin	Homo sapiens	43-47
9242678-9	1997	The calcium chelating agent EGTA inhibited ACTH-induced SAPK activity and the calcium ionophore A23187 induced SAPK activity 3-fold.	Egtazic Acid	28-32	mitogen-activated protein kinase 9	Homo sapiens	56-60
9238019-4	1997	Yeast mutants defective in a Golgi Ca2+ pump (pmr1) or both Golgi and vacuolar Ca2+ pumps (pmr1 pmc1 cnb1) were sensitive to growth on medium containing 10 mM EGTA or 3 mM Mn2+.	Egtazic Acid	159-163	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	91-105
9276479-2	1997	Apo-alpha-lactalbumin possesses a thermal transition with a midpoint about 25-30 degrees C under these conditions (pH 8.1, 10 mM borate, 1 mM EGTA), which is reflected in changes in both fluorescence emission maximum and quantum yield.	Egtazic Acid	142-146	lipoprotein(a)	Homo sapiens	0-9
9238019-5	1997	Expression of ECA1 restored growth of either mutant on EGTA.	Egtazic Acid	55-59	ER-type Ca2+-ATPase 1	Arabidopsis thaliana	14-18
9238019-4	1997	Yeast mutants defective in a Golgi Ca2+ pump (pmr1) or both Golgi and vacuolar Ca2+ pumps (pmr1 pmc1 cnb1) were sensitive to growth on medium containing 10 mM EGTA or 3 mM Mn2+.	Egtazic Acid	159-163	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	46-50
9235918-5	1997	In addition, the proteolysis of cortactin was abolished by treating platelets before but not after collagen stimulation with EGTA or calpeptin.	Egtazic Acid	125-129	cortactin	Homo sapiens	32-41
9267692-5	1997	Infusion of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid for 2 h reduced plasma Ca2+ by 0.36 mmol/L and produced a total plasma PTH response (area under the plasma PTH curve) similar to that with the 5 micrograms/kg rat PTH injection.	Egtazic Acid	12-81	parathyroid hormone	Rattus norvegicus	153-156
9267692-5	1997	Infusion of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid for 2 h reduced plasma Ca2+ by 0.36 mmol/L and produced a total plasma PTH response (area under the plasma PTH curve) similar to that with the 5 micrograms/kg rat PTH injection.	Egtazic Acid	12-81	parathyroid hormone	Rattus norvegicus	189-192
9267692-5	1997	Infusion of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid for 2 h reduced plasma Ca2+ by 0.36 mmol/L and produced a total plasma PTH response (area under the plasma PTH curve) similar to that with the 5 micrograms/kg rat PTH injection.	Egtazic Acid	12-81	parathyroid hormone	Rattus norvegicus	189-192
9218419-9	1997	The FcgammaRII-dependent intracellular Ca2+ rise in primed cells was unaffected by incubation in Ca2+-free medium, whereas the FcgammaRIIIb-dependent transient was significantly decreased when Ca2+ influx was prevented in Ca2+-free medium supplemented with EGTA.	Egtazic Acid	257-261	Fc gamma receptor IIIb	Homo sapiens	127-139
9258340-6	1997	Cytochalasin induced an increase in the rate of transcription of procollagen I (alpha 1), procollagen I (alpha 2), and fibronectin genes by 1.4, 1.5, and 1.9 fold respectively, while trypsinization or EGTA treatment had no or little effects on these gene.	Egtazic Acid	201-205	fibronectin 1	Homo sapiens	119-130
9278268-9	1997	The inhibitory effect of regucalcin was remarkable in the presence of EGTA (0.5 mM), and it was weakened by the addition of Ca2+ (5 microM).	Egtazic Acid	70-74	regucalcin	Rattus norvegicus	25-35
9184157-4	1997	The affinities of the cTnC for the truncated cTnI mutant were: (1) 1.5 x 10(6) M(-1) in EGTA, (2) 28.9 x 10(6) M(-1) in Mg2+, and (3) 87.5 x 10(6) M(-1) in Mg2+ + Ca2+.	Egtazic Acid	88-92	troponin C1, slow skeletal and cardiac type	Homo sapiens	22-26
9204883-6	1997	Third, when Triton X-100 extracts of hepatocyte membrane ghosts were chromatographed on Lf-agarose, a 45-kDa polypeptide (p45) was eluted by EGTA.	Egtazic Acid	141-145	caspase 1	Rattus norvegicus	122-125
9249252-11	1997	In Ca2+-free solution containing 2 mM EGTA, NA (10 microM) transiently increased [Ca2+]i and force.	Egtazic Acid	38-42	carbonic anhydrase 2	Oryctolagus cuniculus	82-85
9237533-4	1997	In 0 Ca medium (0 mM Ca2+ supplemented 1 mM EGTA, referred to as 0 Ca), pH(i) acid shift caused by NMDA (20 microM) declined by about 11%, whereas the initial alkaline shift almost completely disappeared.	Egtazic Acid	44-48	glucose-6-phosphate isomerase	Rattus norvegicus	72-77
9166427-7	1997	First, preventing extracellular calcium influxes, by performing the assays in EGTA, abrogated FcgammaR-mediated IL-12(p40) mRNA suppression.	Egtazic Acid	78-82	interleukin 12b	Mus musculus	118-121
9202183-3	1997	The effect of the calmodulin antagonists on the calcium burst observed upon cell activation was much more pronounced in the presence of extracellular free calcium than in EGTA-containing media; it was not inhibited by wortmannin or thapsigargin.	Egtazic Acid	171-175	calmodulin 1	Homo sapiens	18-28
10072922-4	1997	In the presence of egtazic acid 2 mmol.L-1, I-65 (10, 20, and 30 mumol.L-1), reduced the Ca2+ release induced by thrombin from 52 +/- 11 nmol.L-1 to 34 +/- 9, 19 +/- 6, and 11 +/- 5 nmol.L-1, respectively.	Egtazic Acid	19-31	prothrombin	Oryctolagus cuniculus	113-121
9223621-14	1997	If a ubiquitylation pulse of 30 min was followed in liver crude extracts by the addition of EGTA, which specifically inhibits ubiquityl-calmodulin synthesis, a half-life of calmodulin-conjugate decay of 15-20 min is observed.	Egtazic Acid	92-96	calmodulin	Oryctolagus cuniculus	136-146
9223621-14	1997	If a ubiquitylation pulse of 30 min was followed in liver crude extracts by the addition of EGTA, which specifically inhibits ubiquityl-calmodulin synthesis, a half-life of calmodulin-conjugate decay of 15-20 min is observed.	Egtazic Acid	92-96	calmodulin	Oryctolagus cuniculus	173-183
9184157-4	1997	The affinities of the cTnC for the truncated cTnI mutant were: (1) 1.5 x 10(6) M(-1) in EGTA, (2) 28.9 x 10(6) M(-1) in Mg2+, and (3) 87.5 x 10(6) M(-1) in Mg2+ + Ca2+.	Egtazic Acid	88-92	troponin I3, cardiac type	Homo sapiens	45-49
9214693-4	1997	The PLA2 is Ca2+ dependent and using EGTA-regulated buffers cytosolic or particulate fraction activity was similar at both 10 microm or 10 mm Ca2+ concentrations.	Egtazic Acid	37-41	phospholipase A2 group IB	Homo sapiens	4-8
9204002-4	1997	In general, these effects were significant at peptide concentrations between 10(-12) M and 10(-8) M with a maximal effect at 10(-10) M. In addition, gastrin peptides induced a significant increase in intracellular cAMP levels at 30, 60 and 120 s. Moreover, the inhibitory effect of gastrin-17 on the ingestion capacity of neutrophils (latex bead phagocytosis) was similar to that obtained with EGTA, a well-known extracellular calcium chelating compound.	Egtazic Acid	394-398	gastrin	Homo sapiens	149-156
9141619-3	1997	The increase in [Ca]i was completely blocked by 2 mM EGTA and partially (around 50%) blocked by 10 microM nicardipine, the extents of inhibition of calcium response correlating well with those of inhibition of cytotoxic activity.	Egtazic Acid	53-57	carbonic anhydrase 1	Homo sapiens	17-21
9218131-4	1997	A substantial amount of annexin II was associated with the membrane fraction even after extensive washing with EGTA buffer, indicating the presence of two pools of annexin II.	Egtazic Acid	111-115	annexin A2	Homo sapiens	24-34
9218131-5	1997	The EGTA-resistant membrane-bound annexin II could be partially extracted by 1% Triton X-100 or 60 mM n-octyl-beta-D-glucopyranoside, and completely by 30 mM CHAPS or 0.1% deoxycholate.	Egtazic Acid	4-8	annexin A2	Homo sapiens	34-44
9218131-6	1997	This fraction of annexin II was also extracted by 0.1 M Na2CO3, pH 11 and partitioned into the aqueous phase after being treated with Triton X-114, demonstrating that the EGTA-resistant annexin II is a peripheral membrane protein.	Egtazic Acid	171-175	annexin A2	Homo sapiens	17-27
9218131-6	1997	This fraction of annexin II was also extracted by 0.1 M Na2CO3, pH 11 and partitioned into the aqueous phase after being treated with Triton X-114, demonstrating that the EGTA-resistant annexin II is a peripheral membrane protein.	Egtazic Acid	171-175	annexin A2	Homo sapiens	186-196
9160823-6	1997	Furthermore, calcium-mobilizing agents such as thapsigargin and ionomycin were able to induce an activation of MAPK by a PKC-independent pathway that was totally abolished by preincubation of cells with EGTA.	Egtazic Acid	203-207	protein kinase C, gamma	Rattus norvegicus	121-124
9092683-8	1997	The finding that the thrombin-stimulated formation of IP3 was not dependent on Ca2+ in the medium (EGTA added) indicates that the transient SFLLRN-induced formation of IP3 is not due to failure to cause Ca2+ influx.	Egtazic Acid	99-103	coagulation factor II, thrombin	Homo sapiens	21-29
9057099-5	1997	1) IGF-1 and insulin but not IGF-2 involved a Ca2+ influx through voltage-gated calcium channels: pretreatment of the cells by EGTA and verapamil diminished the IGF-1 or insulin-induced [Ca2+]i but did not block the effect of IGF-2.	Egtazic Acid	127-131	insulin like growth factor 1	Homo sapiens	3-8
9105729-8	1997	Pretreatment of the cells with octanol to block gap junctions, or with EGTA or La3+ to inhibit Ca2+ influx, abolished the synchronization induced by bradykinin or thrombin.	Egtazic Acid	71-75	kininogen 1	Canis lupus familiaris	149-159
9063652-4	1997	The rise in GH release induced by NEAA (200 mumol/l) and GH-releasing hormone (GHRH, 10 nmol/l) was significantly reduced by the addition of EGTA (1.8 mmol/l) and nifedipine (1 mumol/l) to the medium, respectively.	Egtazic Acid	141-145	growth hormone	Capra hircus	12-14
9063652-4	1997	The rise in GH release induced by NEAA (200 mumol/l) and GH-releasing hormone (GHRH, 10 nmol/l) was significantly reduced by the addition of EGTA (1.8 mmol/l) and nifedipine (1 mumol/l) to the medium, respectively.	Egtazic Acid	141-145	somatoliberin	Capra hircus	57-77
9063652-4	1997	The rise in GH release induced by NEAA (200 mumol/l) and GH-releasing hormone (GHRH, 10 nmol/l) was significantly reduced by the addition of EGTA (1.8 mmol/l) and nifedipine (1 mumol/l) to the medium, respectively.	Egtazic Acid	141-145	somatoliberin	Capra hircus	79-83
9067893-8	1997	In contrast, ET-1-induced activation of JNK was significantly reduced by calcium chelation (with BAPTA/AM and EGTA).	Egtazic Acid	110-114	endothelin 1	Homo sapiens	13-17
9067893-8	1997	In contrast, ET-1-induced activation of JNK was significantly reduced by calcium chelation (with BAPTA/AM and EGTA).	Egtazic Acid	110-114	mitogen-activated protein kinase 8	Homo sapiens	40-43
9096366-6	1997	The calcium chelating agent EGTA also inhibits the IL-10 production induced by Nef, and this inhibition is reversed by the addition of calcium along with Nef.	Egtazic Acid	28-32	interleukin 10	Homo sapiens	51-56
9096366-6	1997	The calcium chelating agent EGTA also inhibits the IL-10 production induced by Nef, and this inhibition is reversed by the addition of calcium along with Nef.	Egtazic Acid	28-32	S100 calcium binding protein B	Homo sapiens	79-82
9096366-6	1997	The calcium chelating agent EGTA also inhibits the IL-10 production induced by Nef, and this inhibition is reversed by the addition of calcium along with Nef.	Egtazic Acid	28-32	S100 calcium binding protein B	Homo sapiens	154-157
9057099-5	1997	1) IGF-1 and insulin but not IGF-2 involved a Ca2+ influx through voltage-gated calcium channels: pretreatment of the cells by EGTA and verapamil diminished the IGF-1 or insulin-induced [Ca2+]i but did not block the effect of IGF-2.	Egtazic Acid	127-131	insulin	Homo sapiens	13-20
9057099-5	1997	1) IGF-1 and insulin but not IGF-2 involved a Ca2+ influx through voltage-gated calcium channels: pretreatment of the cells by EGTA and verapamil diminished the IGF-1 or insulin-induced [Ca2+]i but did not block the effect of IGF-2.	Egtazic Acid	127-131	insulin like growth factor 1	Homo sapiens	161-166
9057099-5	1997	1) IGF-1 and insulin but not IGF-2 involved a Ca2+ influx through voltage-gated calcium channels: pretreatment of the cells by EGTA and verapamil diminished the IGF-1 or insulin-induced [Ca2+]i but did not block the effect of IGF-2.	Egtazic Acid	127-131	insulin	Homo sapiens	170-177
9057099-5	1997	1) IGF-1 and insulin but not IGF-2 involved a Ca2+ influx through voltage-gated calcium channels: pretreatment of the cells by EGTA and verapamil diminished the IGF-1 or insulin-induced [Ca2+]i but did not block the effect of IGF-2.	Egtazic Acid	127-131	insulin like growth factor 2	Homo sapiens	226-231
9116917-4	1997	The Ang II-induced AA metabolite release was reduced by chelating extracellular Ca2+ with EGTA.	Egtazic Acid	90-94	angiotensinogen	Rattus norvegicus	4-10
9056482-9	1997	The calcium binding activities of both forms of calretinin were measured by equilibrium dialysis with 45Ca in Ca2+/EGTA buffers.	Egtazic Acid	115-119	calbindin 2	Gallus gallus	48-58
10453550-3	1997	When verapamil, EG-TA, dantrolene, and Fura-2/AM, were added to the medium, the 3H-leucine incorporations stimulated by Ang II were reduced by 17%, 19%, 22%, and 27%.	Egtazic Acid	16-21	angiotensinogen	Homo sapiens	120-126
9013972-4	1997	EDTA or EGTA and bestatin separately inhibited the receptor down-regulation by 98%, indicating the involvement of metalloprotease(s), more specifically an aminopeptidase in the process.	Egtazic Acid	8-12	carboxypeptidase Q	Homo sapiens	155-169
8999881-5	1997	The ability of calcium to activate p70(S6K) was confirmed by blocking the A23187-dependent activation through chelation of extracellular calcium with EGTA; the effect of thapsigargin was inhibited by the cell permeant chelator bis-(o-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetraacetoxymethyl ester (BAPTA-AM).	Egtazic Acid	150-154	annexin A6	Homo sapiens	35-38
9018111-6	1997	Chelation of extracellular Ca2+ by addition of EGTA inhibited the p53 degradation.	Egtazic Acid	47-51	tumor protein p53	Homo sapiens	66-69
8999881-5	1997	The ability of calcium to activate p70(S6K) was confirmed by blocking the A23187-dependent activation through chelation of extracellular calcium with EGTA; the effect of thapsigargin was inhibited by the cell permeant chelator bis-(o-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid tetraacetoxymethyl ester (BAPTA-AM).	Egtazic Acid	150-154	ribosomal protein S6 kinase B1	Homo sapiens	39-42
8900125-0	1996	Dissociation of the alphaIIbbeta3-integrin by EGTA stimulates the tyrosine kinase pp72(syk) without inducing platelet activation.	Egtazic Acid	46-50	spleen associated tyrosine kinase	Homo sapiens	87-90
8952695-4	1996	The prompt AII-induced [Ca2+]i spike was not affected by incubating HCEC in Ca(2+)-free medium containing 2 mM EGTA or by pretreating the cultures with the Ca2+ channel blockers, methoxyverapamil (D600; 50 microM), nickel (1 mM), or lanthanum (1 mM), suggesting that the activation of AII receptors on HCEC triggers the release of Ca2+ from intracellular stores.	Egtazic Acid	111-115	angiotensinogen	Homo sapiens	11-14
8910543-4	1996	These effects were blocked by EGTA or by protein kinase C inhibitors (RO31-8220; GF109203X) and mimicked by ionomycin or phorbol 12-myristate 13-acetate, in the case of pp125(FAK), or their combination in the case of PYK2/CAKbeta.	Egtazic Acid	30-34	protein tyrosine kinase 2	Rattus norvegicus	175-178
8910543-4	1996	These effects were blocked by EGTA or by protein kinase C inhibitors (RO31-8220; GF109203X) and mimicked by ionomycin or phorbol 12-myristate 13-acetate, in the case of pp125(FAK), or their combination in the case of PYK2/CAKbeta.	Egtazic Acid	30-34	protein tyrosine kinase 2 beta	Rattus norvegicus	217-221
8910543-4	1996	These effects were blocked by EGTA or by protein kinase C inhibitors (RO31-8220; GF109203X) and mimicked by ionomycin or phorbol 12-myristate 13-acetate, in the case of pp125(FAK), or their combination in the case of PYK2/CAKbeta.	Egtazic Acid	30-34	protein tyrosine kinase 2 beta	Rattus norvegicus	222-229
8915773-8	1996	The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event.	Egtazic Acid	94-98	C-X-C motif chemokine ligand 8	Homo sapiens	54-57
8915773-8	1996	The calcium ionophore A23187 reproduced the effect of NaF, and this effect was antagonized by EGTA, suggesting that PLD activation was, at least in part, a calcium-regulated event.	Egtazic Acid	94-98	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	116-119
8929549-8	1996	The binding of L-selectin to plasma GlyCAM-1 was completely eliminated with the presence of ethyleneglycol-bis(beta-aminoethylether)-N,N"-tetraacetic acid, showing the calcium dependency of this binding.	Egtazic Acid	92-154	selectin, lymphocyte	Mus musculus	15-25
8929549-8	1996	The binding of L-selectin to plasma GlyCAM-1 was completely eliminated with the presence of ethyleneglycol-bis(beta-aminoethylether)-N,N"-tetraacetic acid, showing the calcium dependency of this binding.	Egtazic Acid	92-154	glycosylation dependent cell adhesion molecule 1	Mus musculus	36-44
9043638-6	1997	A mixture of EDTA, EGTA and trypsin inhibitor also produced a decrease in AChE activity after 24 hours.	Egtazic Acid	19-23	acetylcholinesterase	Ovis aries	74-78
9227836-6	1997	This enhancement was suppressed by EGTA, DL-APV, CNQX, or KN-62, suggesting that the neuronal stimulation effect in CA1 area was mediating through NMDA receptors.	Egtazic Acid	35-39	carbonic anhydrase 1	Rattus norvegicus	116-119
9227836-8	1997	Nevertheless, the percentage of calcium-independent CaM-kinase II activity in the CA3 area was suppressed by EGTA, nitrendipine, KN-62, staurosporin, or H-89, indicating that the activity of CaM-kinase II in the CA3 area was independent of NMDA receptor activation.	Egtazic Acid	109-113	carbonic anhydrase 3	Rattus norvegicus	82-85
9007683-7	1997	A Ca(2+)-dependent inhibition of ICaL consequently to an elevation of the intracellular Ca2+ pool via IP3 might be excluded in the action of ET-1, because of the presence of EGTA in the intrapipette medium.	Egtazic Acid	174-178	endothelin 1	Rattus norvegicus	141-145
8971763-10	1997	The protective effect of erythropoietin was blocked by the simultaneous addition of EGTA.	Egtazic Acid	84-88	erythropoietin	Rattus norvegicus	25-39
9010769-3	1996	In concordance with this, production of TNF-alpha was inhibited by EGTA and/or TMB-8.	Egtazic Acid	67-71	tumor necrosis factor	Mus musculus	40-49
8912879-8	1996	Chelation of extracellular calcium with EGTA at the time of Con A addition resulted in a decrease in IL-2R expression, IL-2 production, and DNA synthesis, but not when CaCl2 equimolar to EGTA was present in the culture medium.	Egtazic Acid	40-44	interleukin 2 receptor subunit alpha	Homo sapiens	101-106
8912879-8	1996	Chelation of extracellular calcium with EGTA at the time of Con A addition resulted in a decrease in IL-2R expression, IL-2 production, and DNA synthesis, but not when CaCl2 equimolar to EGTA was present in the culture medium.	Egtazic Acid	40-44	interleukin 2	Homo sapiens	101-105
8895333-5	1996	Furthermore, reduction of intracellular calcium by addition of EGTA to medium containing A23187 leads to further inhibition of S14 transcription.	Egtazic Acid	63-67	thyroid hormone responsive	Homo sapiens	127-130
8903410-7	1996	Moreover, depletion of extracellular Ca2+ by omission of Ca2+ or by chelating residual Ca2+ with ethyleneglycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) abolished HGF-induced PLD activation.	Egtazic Acid	97-165	hepatocyte growth factor	Rattus norvegicus	183-186
8946653-11	1996	In rings from saline-treated conscious and anesthetized rats, cGMP accumulation was significantly reduced by EGTA and L-NAME, indicating calcium-dependent constitutive (cNOS) activity.	Egtazic Acid	109-113	nitric oxide synthase 3	Rattus norvegicus	137-167
8946653-11	1996	In rings from saline-treated conscious and anesthetized rats, cGMP accumulation was significantly reduced by EGTA and L-NAME, indicating calcium-dependent constitutive (cNOS) activity.	Egtazic Acid	109-113	nitric oxide synthase 3	Rattus norvegicus	169-173
8914579-9	1996	Serum activity in enhancing the liver uptake for PE- and aGM1-containing liposomes can be blocked by treatment of serum with EDTA, EGTA/Mg2+ and high temperature (56 degrees C), suggesting the involvement of complement system.	Egtazic Acid	131-135	phosphoglucomutase 3	Mus musculus	57-61
8900125-1	1996	Incubation of human platelets with EGTA under conditions that dissociate the alphaIIbbeta3-integrin stimulated tyrosine phosphorylation of pp72(syk) (6.8-fold) and of proteins of 62 (2.	Egtazic Acid	35-39	spleen associated tyrosine kinase	Homo sapiens	144-147
8900125-7	1996	Stimulation of tyrosine phosphorylation of pp72(syk), p62, p68, and p130 induced by EGTA was not observed in thrombasthenic platelets, which lack the alphaIIbbeta3-integrin.	Egtazic Acid	84-88	spleen associated tyrosine kinase	Homo sapiens	48-51
8900125-7	1996	Stimulation of tyrosine phosphorylation of pp72(syk), p62, p68, and p130 induced by EGTA was not observed in thrombasthenic platelets, which lack the alphaIIbbeta3-integrin.	Egtazic Acid	84-88	nucleoporin 62	Homo sapiens	54-57
8900125-7	1996	Stimulation of tyrosine phosphorylation of pp72(syk), p62, p68, and p130 induced by EGTA was not observed in thrombasthenic platelets, which lack the alphaIIbbeta3-integrin.	Egtazic Acid	84-88	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	59-62
8900125-7	1996	Stimulation of tyrosine phosphorylation of pp72(syk), p62, p68, and p130 induced by EGTA was not observed in thrombasthenic platelets, which lack the alphaIIbbeta3-integrin.	Egtazic Acid	84-88	nucleolar and coiled-body phosphoprotein 1	Homo sapiens	68-72
8831688-5	1996	When the cytotoxic assay was performed in the presence of EGTA, a Ca2+ chelator, which prevents cytotoxic granule exocytosis and perforin polymerization on target cell membranes, only the CD45- target cells were killed by the CTL clone.	Egtazic Acid	58-62	protein tyrosine phosphatase receptor type C	Homo sapiens	188-192
8894140-6	1996	The depletion of extracellular Ca2+ by EGTA markedly reduced the FCS-induced formation of choline.	Egtazic Acid	39-43	carbonic anhydrase 2	Mus musculus	31-34
8874220-5	1996	In addition, fluorescence measurements with Fura-2-labeled eosinophils in the presence of EGTA indicated Ca(2+)-mobilization from intracellular stores by Eotaxin.	Egtazic Acid	90-94	C-C motif chemokine ligand 11	Homo sapiens	154-161
8702954-11	1996	Exogenous 125I-annexin II bound to EGTA-washed endothelial cells with high affinity (Kd 49 nM) and in a calcium-dependent (I50 = 3 microM), phospholipid-sensitive manner.	Egtazic Acid	35-39	annexin A2	Homo sapiens	15-25
8844973-4	1996	In cells loaded with EGTA/AM or treated in low or no Ca2+ HBSS, c-fos induction was reduced similarly in both cell types.	Egtazic Acid	21-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-69
8883283-4	1996	Pretreatment of platelets with EGTA decreased the maximum PK33 activity induced by thrombin.	Egtazic Acid	31-35	coagulation factor II, thrombin	Homo sapiens	83-91
8702797-5	1996	Of these two chemokines, only Gro-alpha induced an influx of calcium in neutrophils as judged by the sensitivity of the mobilization of calcium to the extracellular calcium chelator EGTA and to the nonselective divalent cation channel inhibitor SK&amp;F 96365, as well as by manganese quenching experiments.	Egtazic Acid	182-186	C-X-C motif chemokine ligand 1	Homo sapiens	30-39
8853354-2	1996	The time course of I(tail) followed that of Cai transients I(tail) was suppressed by dialyzing cells with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, applying 5 mM caffeine, or substituting external Na+ with Li+, indicating that this current was mainly generated by INa/Ca.	Egtazic Acid	106-175	internexin neuronal intermediate filament protein alpha	Homo sapiens	293-296
8806458-8	1996	Although the dephosphorylation of cofilin was observed in cells treated with the calcium ionophore A23187, the phosphorylation level of cofilin was restored when the cells were further incubated in the presence of EGTA.	Egtazic Acid	214-218	cofilin 1	Homo sapiens	34-41
8806458-8	1996	Although the dephosphorylation of cofilin was observed in cells treated with the calcium ionophore A23187, the phosphorylation level of cofilin was restored when the cells were further incubated in the presence of EGTA.	Egtazic Acid	214-218	cofilin 1	Homo sapiens	136-143
8706879-3	1996	The effect of CaM was Ca2+ dependent and was not observed when the intracellular Ca2+ was buffered to 1 nM with EGTA.	Egtazic Acid	112-116	calmodulin	Bos taurus	14-17
8699245-6	1996	Intracellular dialysis with 1 mM or higher EGTA spares only the BK channels activated by the highest [Ca2+]i during influx, whereas dialysis with 1 mM or higher BAPTA blocks activation of all BK channels.	Egtazic Acid	43-47	carbonic anhydrase 2	Rattus norvegicus	102-105
8698514-6	1996	Depletion of intracellular Ca stores with thapsigargin, or extracellular Ca with EGTA, significantly inhibited the upregulation of the CD11b/CD18 integrin in response to fMLP but not LPS.	Egtazic Acid	81-85	integrin subunit alpha M	Homo sapiens	135-140
8698514-6	1996	Depletion of intracellular Ca stores with thapsigargin, or extracellular Ca with EGTA, significantly inhibited the upregulation of the CD11b/CD18 integrin in response to fMLP but not LPS.	Egtazic Acid	81-85	integrin subunit beta 2	Homo sapiens	141-145
8698514-6	1996	Depletion of intracellular Ca stores with thapsigargin, or extracellular Ca with EGTA, significantly inhibited the upregulation of the CD11b/CD18 integrin in response to fMLP but not LPS.	Egtazic Acid	81-85	formyl peptide receptor 1	Homo sapiens	170-174
8670800-6	1996	In WT and GAD plant extracts, GAD activity is inhibited by EGTA and by the CaM antagonist trifluoperazine, and is associated with a CaM-containing protein complex of approximately 500 kDa.	Egtazic Acid	59-63	glutamate decarboxylase	Nicotiana tabacum	10-13
8660407-3	1996	This Ca2+-induced affinity shift was insensitive to the calmodulin antagonist, mastoparan, was abolished irreversibly by a 2-min exposure to 3 mm Mg2+ + 2 mm EGTA (Mg + EGTA), and was not restored by the application of calmodulin (CAM).	Egtazic Acid	158-162	calmodulin 1	Homo sapiens	56-66
8660407-3	1996	This Ca2+-induced affinity shift was insensitive to the calmodulin antagonist, mastoparan, was abolished irreversibly by a 2-min exposure to 3 mm Mg2+ + 2 mm EGTA (Mg + EGTA), and was not restored by the application of calmodulin (CAM).	Egtazic Acid	169-173	calmodulin 1	Homo sapiens	219-229
8660407-3	1996	This Ca2+-induced affinity shift was insensitive to the calmodulin antagonist, mastoparan, was abolished irreversibly by a 2-min exposure to 3 mm Mg2+ + 2 mm EGTA (Mg + EGTA), and was not restored by the application of calmodulin (CAM).	Egtazic Acid	169-173	calmodulin 1	Homo sapiens	231-234
8670800-6	1996	In WT and GAD plant extracts, GAD activity is inhibited by EGTA and by the CaM antagonist trifluoperazine, and is associated with a CaM-containing protein complex of approximately 500 kDa.	Egtazic Acid	59-63	glutamate decarboxylase	Nicotiana tabacum	30-33
8647917-9	1996	The depletion of extracellular Ca2+ by EGTA exclusively reduced the thrombin-induced choline formation.	Egtazic Acid	39-43	coagulation factor II	Mus musculus	68-76
8819155-5	1996	Stopped-flow studies show that the EGTA-induced dissociation of WF10 from Ca4-CaM proceeds by a reversible relaxation mechanism from a kinetic intermediate state, also involving half-saturation of CaM, and the same mechanism is evident for the full target peptide.	Egtazic Acid	35-39	calmodulin 1	Homo sapiens	78-81
8819155-5	1996	Stopped-flow studies show that the EGTA-induced dissociation of WF10 from Ca4-CaM proceeds by a reversible relaxation mechanism from a kinetic intermediate state, also involving half-saturation of CaM, and the same mechanism is evident for the full target peptide.	Egtazic Acid	35-39	calmodulin 1	Homo sapiens	197-200
8799897-11	1996	The [Ca2+]i dependence of exo- and endocytosis was studied by photorelease of Ca2+ from the "caged" precursor Ca(2+)-nitrophenyl-EGTA (Ca(2+)-NP-EGTA).	Egtazic Acid	129-133	5'-3' exoribonuclease 1	Mus musculus	26-29
8662717-7	1996	The erythropoietin-induced down-regulation of c-myb mRNA levels could be demonstrated also in the presence of EGTA and was resistant to calmodulin antagonists and cyclosporin A.	Egtazic Acid	110-114	erythropoietin	Mus musculus	4-18
8662717-7	1996	The erythropoietin-induced down-regulation of c-myb mRNA levels could be demonstrated also in the presence of EGTA and was resistant to calmodulin antagonists and cyclosporin A.	Egtazic Acid	110-114	myeloblastosis oncogene	Mus musculus	46-51
8795086-4	1996	(2) Preventing influx of extracellular Ca2+ by incubation in Ca(2+)-free/0.1 mM EGTA solution inhibited the acetylcholine (10(-4) M)-induced contraction by 60 +/- 3% compared to only 46 +/- 5% (P &lt; 0.05) for CCK (10(-6) M)-induced contraction.	Egtazic Acid	80-84	cholecystokinin	Cavia porcellus	211-214
8771702-9	1996	PKC was extracted from the membrane with a buffer containing 2.5 mM EGTA and 2.5 mM EDTA, and purified by DE52 column chromatography.	Egtazic Acid	68-72	protein kinase C, gamma	Rattus norvegicus	0-3
8639635-2	1996	Several proteins were eluted from a recombinant annexin I column in the presence of 2 mM EGTA, including protein kinase C (PKC), members of the annexin family, and a 26 kDa protein that appeared as the most prominent band on SDS-PAGE.	Egtazic Acid	89-93	annexin A1	Bos taurus	48-57
8621897-4	1996	When up-regulation of Fas lytic function was induced by PMA and ionomycin, EGTA blocked both activation of lytic function and expression of Fas ligand detected by FACS analysis.	Egtazic Acid	75-79	acyl-CoA synthetase long-chain family member 1	Mus musculus	163-167
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Egtazic Acid	207-277	nitric oxide synthase 2	Homo sapiens	13-17
8645139-6	1996	The short C-terminal tryptic peptide of calmodulin obtained in the presence of EGTA (TR3E, residues 107-148) interacts with caldesmon and calponin with Kd values of 23.9 and 12.1 microM, whereas the large N-terminal peptide TR1E (residues 1-106) interacts with both caldesmon and calponin with a very low affinity (Kd 60 microM).	Egtazic Acid	79-83	calmodulin 1	Homo sapiens	40-50
8620557-5	1996	EGTA-MgCl2 inhibited bystander lysis and reduced the release of BLT esterase.	Egtazic Acid	0-4	granzyme A	Mus musculus	64-76
8815745-3	1996	Upon removal of Ca2+ with EGTA, the conformation of calmodulin changes, and the phenothiazine--CaM complex dissociates.	Egtazic Acid	26-30	calmodulin	Saccharomyces cerevisiae S288C	52-62
8815745-3	1996	Upon removal of Ca2+ with EGTA, the conformation of calmodulin changes, and the phenothiazine--CaM complex dissociates.	Egtazic Acid	26-30	calmodulin	Saccharomyces cerevisiae S288C	95-98
8815745-10	1996	Upon elution with an EGTA buffer, the ProtA--CaM fusion protein was purified, as confirmed by SDS-PAGE electrophoresis and Western blot analysis.	Egtazic Acid	21-25	calmodulin	Saccharomyces cerevisiae S288C	45-48
8736735-9	1996	The total adsorbed mass and particularly C3 antibody deposition were suppressed by using EGTA-Mg2+ serum.	Egtazic Acid	89-93	complement C3	Ovis aries	41-43
8928824-7	1996	In Ca(2+)-free external solutions (containing 0.4-1 mM EGTA), ANG II still produced oscillation in [Ca2+]i.	Egtazic Acid	55-59	angiotensinogen	Rattus norvegicus	62-68
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Egtazic Acid	207-277	interferon gamma	Homo sapiens	66-82
8928785-2	1996	Induction of iNOS transcription?by a combination of the cytokines interferon-gamma and IL-1 beta was inhibited by genistein, pyrrolidine dithiocarbamate, or dexamethasone and unaffected by pretreatment with ethylene glycol-bis(beta-aminoethyl ether)-N, N,N",N"-tetraacetic acid, basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), or the isoflavone daidzein.	Egtazic Acid	207-277	interleukin 1 beta	Homo sapiens	87-96
8845173-8	1996	PC attachment by SP-A was calcium- and mannose-dependent as SP-A-mediated attachment was significantly reduced in the presence of EGTA and mannose to 13.1 +/- 1.6% and 19.3 +/- 2.6%, respectively (P&lt;0.05).	Egtazic Acid	130-134	surfactant protein A1	Homo sapiens	17-21
8771559-11	1996	Removal of extracellular Ca2+ with EGTA enhanced the PACAP-induced increases in both cellular cAMP and mRNA levels of TH and DBH, suggesting that Ca2+ has an inhibitory effect on the induction of TH and DBH mRNAs.	Egtazic Acid	35-39	adenylate cyclase activating polypeptide 1	Homo sapiens	53-58
8771559-11	1996	Removal of extracellular Ca2+ with EGTA enhanced the PACAP-induced increases in both cellular cAMP and mRNA levels of TH and DBH, suggesting that Ca2+ has an inhibitory effect on the induction of TH and DBH mRNAs.	Egtazic Acid	35-39	dopamine beta-hydroxylase	Homo sapiens	125-128
8771559-11	1996	Removal of extracellular Ca2+ with EGTA enhanced the PACAP-induced increases in both cellular cAMP and mRNA levels of TH and DBH, suggesting that Ca2+ has an inhibitory effect on the induction of TH and DBH mRNAs.	Egtazic Acid	35-39	tyrosine hydroxylase	Homo sapiens	118-120
8771559-11	1996	Removal of extracellular Ca2+ with EGTA enhanced the PACAP-induced increases in both cellular cAMP and mRNA levels of TH and DBH, suggesting that Ca2+ has an inhibitory effect on the induction of TH and DBH mRNAs.	Egtazic Acid	35-39	dopamine beta-hydroxylase	Homo sapiens	203-206
8619616-4	1996	Following the Ca2+ buffer wash, the surfactant pellet is washed in buffer containing EGTA and Mg2+ which releases the bound SP-A in almost pure form.	Egtazic Acid	85-89	surfactant protein A1	Homo sapiens	124-128
8845173-8	1996	PC attachment by SP-A was calcium- and mannose-dependent as SP-A-mediated attachment was significantly reduced in the presence of EGTA and mannose to 13.1 +/- 1.6% and 19.3 +/- 2.6%, respectively (P&lt;0.05).	Egtazic Acid	130-134	surfactant protein A1	Homo sapiens	60-64
8721751-2	1996	In Arabidopsis, lanthanum or EGTA caused a partial inhibition of both cold shock [Ca2+]cyt elevation and cold-dependent kin1 gene expression.	Egtazic Acid	29-33	stress-responsive protein (KIN1) / stress-induced protein (KIN1)	Arabidopsis thaliana	120-124
8678916-7	1996	The depletion of extracellular Ca2+ by (ethylenebis(oxyethylenenitrilo)) tetraacetic acid (EGTA) significantly reduced the Ang II-induced formation of choline.	Egtazic Acid	39-89	angiotensinogen	Rattus norvegicus	123-129
8678916-7	1996	The depletion of extracellular Ca2+ by (ethylenebis(oxyethylenenitrilo)) tetraacetic acid (EGTA) significantly reduced the Ang II-induced formation of choline.	Egtazic Acid	91-95	angiotensinogen	Rattus norvegicus	123-129
8882626-15	1996	ET-1 (100 nM) induced a transient increase in [Ca2+]i in a Ca(2+)-free, 2 mM EGTA-containing physiological saline solution (Ca(2+)-free PSS), and a small sustained contraction which was significantly different from that induced by ET-1 (100 nM) in normal PSS.	Egtazic Acid	77-81	endothelin-1	Oryctolagus cuniculus	0-4
8821542-4	1996	COMT activity, evaluated by the ability to methylate adrenaline to metanephrine, was determined in liver and kidney homogenates prepared in 0.5 mM phosphate buffer (pH = 7.8) containing pargyline (0.1 mM), MgCl2 (0.1 mM), EGTA (1 mM) and S-adenosyl-L-methionine (0.1 mM).	Egtazic Acid	222-226	catechol-O-methyltransferase	Rattus norvegicus	0-4
8762014-3	1996	Further, the dependency of the IL-2 response on calcium (Ca2+) ions was analysed by the addition of the chelating agent EGTA.	Egtazic Acid	120-124	interleukin 2	Homo sapiens	31-35
8557113-5	1996	This translocation of Cap Z to the supernatant is also observed when resting platelets are lysed into buffer containing 50-100 microM GTP gamma S and 10 mM EGTA.	Egtazic Acid	156-160	capping actin protein of muscle Z-line subunit alpha 2	Homo sapiens	22-27
8720417-9	1996	AII- or serum-stimulated DNA synthesis was almost abolished by EGTA, whereas TMB-8, verapamil, and nifedipine had little or no effect.	Egtazic Acid	63-67	angiotensinogen	Rattus norvegicus	0-3
8730809-3	1996	This potentiation of the NMDAR1 current was not inhibited by the intracellular injection of EGTA.	Egtazic Acid	92-96	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	25-31
8720417-6	1996	Conversely, the AII response was inhibited by EGTA, a chelator of Ca2+ ions and by verapamil and nifedipine, two Ca2+ channel blockers or by incubation of the cells without exogenous Ca2+.	Egtazic Acid	46-50	angiotensinogen	Rattus norvegicus	16-19
8742363-3	1996	It was found that sequestering of calcium by EGTA abolished IFN-alpha induction by HSV-infected cells.	Egtazic Acid	45-49	interferon alpha 1	Homo sapiens	60-69
8848266-3	1996	This effect was blocked by removal of free Ca2+ (with EGTA) or by substitution of normal phospholipids with non-substrate lipids, indicating specificity of PLA2 activity.	Egtazic Acid	54-58	phospholipase A2 group IB	Homo sapiens	156-160
8573088-6	1996	Addition of EGTA to block bivalent cation influx inhibited the majority of ATP-stimulated PLD activity.	Egtazic Acid	12-16	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	90-93
8633785-9	1995	The ANN method was also used to resolve mixtures of Fe(III), Co(II), and Zn(II) by displacement from their EGTA complexes with 4-(2-pyridylazo)resorcinol (PAR) using a stopped-flow injection assembly including a diode array detector.	Egtazic Acid	107-111	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
8725007-5	1996	Incubation of hepatocytes in a Ca(2+)-free medium with or without ethylene glycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid blocked by 40% the fructose-induced activation of cholesterol esterase whereas the rise in AMP/ATP was unaffected.	Egtazic Acid	66-135	carboxyl ester lipase	Rattus norvegicus	186-206
8730988-6	1996	In contrast, ERG responses continued throughout EGTA treatment, although the size and shape of the response was altered.	Egtazic Acid	48-52	ETS transcription factor ERG	Homo sapiens	13-16
8554572-6	1995	The AVP-induced current was totally abolished when the intracellular EGTA concentration was increased from 0.05 mM to 10 mM or Ca2+ was removed from the extracellular perfusing solution.	Egtazic Acid	69-73	arginine vasopressin	Homo sapiens	4-7
8835317-10	1996	When [Ca++]i was decreased by treating the cells with 5 mM EGTA and 20 microM ionomycin, pHi decreased by 0.35 +/- 0.02 units.	Egtazic Acid	59-63	glucose-6-phosphate isomerase	Oryctolagus cuniculus	89-92
7495792-9	1995	EGTA also changed the native PAGE mobility of iNOS and increased the intensity of a band which comigrates with CaM.	Egtazic Acid	0-4	nitric oxide synthase 2, inducible	Mus musculus	46-50
7495792-9	1995	EGTA also changed the native PAGE mobility of iNOS and increased the intensity of a band which comigrates with CaM.	Egtazic Acid	0-4	calmodulin 2	Mus musculus	111-114
7595540-10	1995	ZnCl2, EDTA, EGTA, and the omission of Ca2+ inhibited the formation of pYE27 (preproTRH25-50), one of the proTRH N-terminal products, by 48, 82, 72, and 45%, respectively.	Egtazic Acid	13-17	thyrotropin releasing hormone	Rattus norvegicus	81-87
7543927-6	1995	The apparent increase in NAT stability caused by K+ was abolished by addition of EGTA or nifedipine and potentiated by Bay K 8644, indicating the involvement of Ca2+ influx through dihydropyridine-sensitive channels.	Egtazic Acid	81-85	arylamine N-acetyltransferase, liver isozyme	Gallus gallus	25-28
9026776-5	1995	Intracellular perfusion of the c-kit+ cells with ethylenebis (okonitrilo) tetraacetate (EGTA) as well as a nominally Ca(2+)-free external solution or low holding voltage (&lt; -60 mV) prevented the rhythmic current.	Egtazic Acid	88-92	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	31-36
7594501-8	1995	The binding of factor H could be inhibited under conditions that inactivate the classical complement pathway (EGTA and heat treatment), but not by factor B depletion of the serum, demonstrating that classical pathway activation was responsible for factor H binding.	Egtazic Acid	110-114	complement factor H	Homo sapiens	15-23
8576856-14	1995	The slow AHP was attenuated by Ca(2+)-free medium, apamin or the Ca2+ chelator EGTA, suggesting a role for the Ca(2+)-activated K+ conductance, IAHP.	Egtazic Acid	79-83	carbonic anhydrase 2	Rattus norvegicus	65-68
8711265-5	1995	These observations indicate that Ca2+ in the tubule lumen is important for the maintenance of normal proximal bicarbonate transport, but the low Ca2+ level necessary to impair this transport mechanism is achieved only in the presence of EGTA, a condition that simulates the absence of parathyroid hormone.	Egtazic Acid	237-241	parathyroid hormone	Rattus norvegicus	285-304
7487907-2	1995	Bradykinin-stimulated responses exhibited a requirement for extracellular Ca2+ influx, since they were inhibited in the presence of EGTA.	Egtazic Acid	132-136	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	74-77
8566177-2	1995	After a stabilization period, incubation for 5 min with acetylcholine, bradykinin, ADP and bovine thrombin resulted in a receptor-mediated increase in cyclic GMP which could be blocked by EGTA, N-omega-nitro-L-arginine methyl ester (L-NAME) and NG-monomethyl-L-arginine (L-NMMA).	Egtazic Acid	188-192	kininogen 1	Bos taurus	71-81
8566177-2	1995	After a stabilization period, incubation for 5 min with acetylcholine, bradykinin, ADP and bovine thrombin resulted in a receptor-mediated increase in cyclic GMP which could be blocked by EGTA, N-omega-nitro-L-arginine methyl ester (L-NAME) and NG-monomethyl-L-arginine (L-NMMA).	Egtazic Acid	188-192	coagulation factor II, thrombin	Bos taurus	98-106
7592592-6	1995	Simultaneous photolysis of caged ATP and NP-EGTA was followed by a td of 194 ms at 5 microM CaM and a rate of MLC20 phosphorylation intermediate between these parameters following photolysis of, respectively, NP-EGTA and caged ATP.	Egtazic Acid	44-48	myosin light chain 12B	Homo sapiens	110-115
7592592-6	1995	Simultaneous photolysis of caged ATP and NP-EGTA was followed by a td of 194 ms at 5 microM CaM and a rate of MLC20 phosphorylation intermediate between these parameters following photolysis of, respectively, NP-EGTA and caged ATP.	Egtazic Acid	212-216	myosin light chain 12B	Homo sapiens	110-115
8521832-4	1995	Both peptides bound calmodulin in the presence as well as in the absence of Ca2+ (i.e. in the presence of excess EGTA).	Egtazic Acid	113-117	calmodulin 1	Homo sapiens	20-30
7559616-5	1995	The stimulation of membrane PKCs activity and the prevention of MARCKS phosphorylation by ionomycin required external Ca2+ because they were both abolished by adding 5 mM EGTA to the culture medium.	Egtazic Acid	171-175	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	64-70
8588187-4	1995	The ET-1 induced increase in [Ca2+]i was suppressed by 1 mM EGTA, a calcium chelating agent in the medium.	Egtazic Acid	60-64	endothelin 1	Homo sapiens	4-8
7575534-2	1995	ICAM-1 expression was observed even in normal hepatocytes following liver perfusion with Hank"s balanced salt solution at a flow rate of 4.2 mL/g liver weight/min or with the same solution containing collagenase or EGTA at the physiological flow rate (1.4 mL/g liver weight/min).	Egtazic Acid	215-219	intercellular adhesion molecule 1	Rattus norvegicus	0-6
7669029-5	1995	The IIB vWF-evoked (3 micrograms/ml) cytosolic Ca2+ increase was negligibly affected by ADP scavengers or protein kinase C inhibitors; it was drastically reduced by EGTA, La3+, Ni2+ or acetylsalicylate and abolished by the phospholipase A2 inhibitors ONO-RS-082 or oleolyloxyethyl-phosphocholine.	Egtazic Acid	165-169	von Willebrand factor	Homo sapiens	8-11
7573430-6	1995	The STA2-induced formation of choline was significantly reduced by chelating extracellular Ca2+ with ethylene glycol-bis(beta-amino-ethyl ether)-N,N,N",N"-tetraacetic acid.	Egtazic Acid	101-171	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Mus musculus	4-8
8570574-5	1995	When Ca2+ channel blockers or EGTA (2 mM) were added to the culture medium, dPRL release and [3H] leucine incorporation into proteins decreased.	Egtazic Acid	30-34	Prl	Drosophila melanogaster	76-80
7646448-4	1995	The stimulation of glucose-6-phosphatase and mannose-6-phosphatase activities by histone II-A was found to be reversed by EGTA.	Egtazic Acid	122-126	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	19-40
7653517-4	1995	PA also caused a concentration-dependent increase in in vitro activity of myocytic PLC in the presence or absence of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	117-186	LOC100009319	Oryctolagus cuniculus	83-86
7629146-1	1995	Once two radioactive Ca2+ coming from the cytoplasm are bound to the transport sites of the nonphosphorylated ATPase, excess EGTA induces rapid dissociation of both ions, whereas excess nonradioactive Ca2+ only reaches one of the two bound Ca2+.	Egtazic Acid	125-129	dynein axonemal heavy chain 8	Homo sapiens	110-116
7653517-5	1995	PLC-delta 1, the predominant isozyme of PLC expressed in adult rabbit ventricular myocytes, bound to liposomes of PA with high affinity in the presence of EGTA.	Egtazic Acid	155-159	LOC100009319	Oryctolagus cuniculus	0-3
7541726-6	1995	Once activated, Th1 effectors express cytotoxic activity in the presence of EGTA+MgCl2, an experimental [Ca2+]ext-independent condition characteristic of FasL-mediated cytotoxicity.	Egtazic Acid	76-80	negative elongation factor complex member C/D, Th1l	Mus musculus	16-19
7653517-5	1995	PLC-delta 1, the predominant isozyme of PLC expressed in adult rabbit ventricular myocytes, bound to liposomes of PA with high affinity in the presence of EGTA.	Egtazic Acid	155-159	LOC100009319	Oryctolagus cuniculus	40-43
7593331-4	1995	We show here that cingulin is phosphorylated in vivo on serine, and its specific phosphorylation is not significantly changed by treatment of confluent MDCK monolayers with PMA, with the protein kinase inhibitor H-7, or with the calcium chelator EGTA.	Egtazic Acid	246-250	cingulin	Canis lupus familiaris	18-26
7624890-3	1995	Likewise, ethyleneglycol-bis (aminoethyl ether) tetraacetic acid (EGTA) attenuated quartz-, chrysotile- and fMLP-induced elevation of [Ca2+]i and ROM production.	Egtazic Acid	66-70	formyl peptide receptor 1	Homo sapiens	108-112
7608202-9	1995	Prevention of calcium influx with external EGTA also inhibited NFAT activation, indicating that release of calcium from internal stores was insufficient for sustained activation of mast cell NFAT.	Egtazic Acid	43-47	nuclear factor of activated T-cells 5	Rattus norvegicus	63-67
7614716-11	1995	Pretreatment with EGTA or the intracellular Ca2+ chelator BAPTA/AM strongly suppressed the strain-induced MCP-1 mRNA.	Egtazic Acid	18-22	C-C motif chemokine ligand 2	Homo sapiens	106-111
8537818-6	1995	The value of beta, the buffering power of myoplasm, was determined in fibers equilibrated with a combination of EGTA, phenol red, and fura-2; its mean value was 22 mM/pH unit.	Egtazic Acid	112-116	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	13-17
7541726-6	1995	Once activated, Th1 effectors express cytotoxic activity in the presence of EGTA+MgCl2, an experimental [Ca2+]ext-independent condition characteristic of FasL-mediated cytotoxicity.	Egtazic Acid	76-80	Fas ligand (TNF superfamily, member 6)	Mus musculus	154-158
7635261-6	1995	In Ca(2+)-free solution containing 0.2 mM EGTA, ET-1 elicited a transient increase in [Ca2+]i and tension.	Egtazic Acid	42-46	endothelin 1	Canis lupus familiaris	48-52
7628537-2	1995	In an attempt to provide evidence for the involvement of these proteins in differentiation, the effect of transforming growth factor beta 1 (TGF-beta) and EGTA on the expression and activity of (2"-5") oligoadenylate synthetase (2-5A synthetase) and double-stranded RNA activated protein kinase (PKR) during myogenesis of rat primary skeletal muscle cultures or the myogenic cell line L8 was studied.	Egtazic Acid	155-159	2'-5' oligoadenylate synthetase 1A	Rattus norvegicus	195-227
7602380-0	1995	Stimulation of plasma membrane Ca2+ pump by calbindin-D28k and calmodulin is additive in EGTA-free solutions.	Egtazic Acid	89-93	calbindin 1	Rattus norvegicus	44-53
7602380-0	1995	Stimulation of plasma membrane Ca2+ pump by calbindin-D28k and calmodulin is additive in EGTA-free solutions.	Egtazic Acid	89-93	calmodulin 1	Rattus norvegicus	63-73
7602380-2	1995	Previous studies have shown that in enterocytes this Ca(2+)-pumping ATPase could be stimulated by vitamin D-dependent Ca(2+)-binding protein, calbindin-D9k, in ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA)-free solutions.	Egtazic Acid	160-229	S100 calcium binding protein G	Rattus norvegicus	142-155
7602380-2	1995	Previous studies have shown that in enterocytes this Ca(2+)-pumping ATPase could be stimulated by vitamin D-dependent Ca(2+)-binding protein, calbindin-D9k, in ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA)-free solutions.	Egtazic Acid	231-235	S100 calcium binding protein G	Rattus norvegicus	142-155
7602380-6	1995	However, when EGTA-free solutions were used, calbindin D28k and parvalbumin significantly increased ATP-dependent Ca2+ uptake in erythrocyte as well as in enterocyte-derived membrane vesicles.	Egtazic Acid	14-18	calbindin 1	Rattus norvegicus	45-54
7602380-6	1995	However, when EGTA-free solutions were used, calbindin D28k and parvalbumin significantly increased ATP-dependent Ca2+ uptake in erythrocyte as well as in enterocyte-derived membrane vesicles.	Egtazic Acid	14-18	parvalbumin	Rattus norvegicus	64-75
7602380-7	1995	In contrast, calmodulin significantly increased active Ca2+ uptake in erythrocyte vesicles in the absence as well as in the presence of EGTA.	Egtazic Acid	136-140	calmodulin 1	Rattus norvegicus	13-23
7751651-10	1995	Removing extracellular Ca2+ with EGTA inhibited LPS induction of TYKi, whereas increasing intracellular calcium with the calcium ionophore A23187 had little effect on the levels of the TYKi transcript.	Egtazic Acid	33-37	toll-like receptor 4	Mus musculus	48-51
7598740-9	1995	The PKC activator phorbol 12-myristate 13-acetate (0.4 microM) stimulated ET-1 release 1.4-fold (P &lt; 0.01) and its effect was abolished by EGTA (5 mM).	Egtazic Acid	142-146	endothelin 1	Homo sapiens	74-78
7772046-5	1995	In separate experiments we demonstrate that a calcium ion concentration [Ca2+] of 0.8 microM is sufficient for maximum binding of the EGTA-resistant form to membranes.	Egtazic Acid	134-138	carbonic anhydrase 2	Homo sapiens	73-76
7772046-6	1995	In contrast a higher [Ca2+] was required to induce maximal binding of the annexin V which could be extracted with EGTA.	Egtazic Acid	114-118	carbonic anhydrase 2	Homo sapiens	22-25
7772046-6	1995	In contrast a higher [Ca2+] was required to induce maximal binding of the annexin V which could be extracted with EGTA.	Egtazic Acid	114-118	annexin A5	Homo sapiens	74-83
7772046-12	1995	This suggests that the EGTA-resistant form of annexin V is binding to a membrane component other than phosphatidylserine.	Egtazic Acid	23-27	annexin A5	Homo sapiens	46-55
7598716-3	1995	This effect on DBH was also observed with ionomycin, reversed by EGTA and unaffected by cycloheximide.	Egtazic Acid	65-69	dopamine beta-hydroxylase	Bos taurus	15-18
7797544-3	1995	We have used the frequency domain method of fluorescence resonance energy transfer to measure TnT-TnC and TnT-TnI distances and distance distributions, in the presence of Ca2+, Mg2+, or EGTA, in TnC.TnI.TnT complexes.	Egtazic Acid	186-190	tenascin C	Homo sapiens	195-198
7751651-10	1995	Removing extracellular Ca2+ with EGTA inhibited LPS induction of TYKi, whereas increasing intracellular calcium with the calcium ionophore A23187 had little effect on the levels of the TYKi transcript.	Egtazic Acid	33-37	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	Mus musculus	65-69
7782894-5	1995	Phospholipase A2 activity was assessed in lung, liver, kidney and heart cytosol and microsomes in the presence (5 mmol/L CaCl2) or absence (5 mmol/L EGTA) of calcium with dipalmitoylphosphatidylcholine at pH 6.5.	Egtazic Acid	149-153	phospholipase A2 group IB	Rattus norvegicus	0-16
7535782-10	1995	EGTA strongly inhibited the Et-1 gene expression.	Egtazic Acid	0-4	endothelin 1	Homo sapiens	28-32
8586621-5	1995	Both the inactivation of CaM-kinase IV by Ca2+/calmodulin and the restoration of its activity by Mg2+/EGTA were time- and temperature-dependent reactions.	Egtazic Acid	102-106	calcium/calmodulin dependent protein kinase IV	Homo sapiens	25-38
7713904-5	1995	Both in intact cells and in an acellular system, the increase of PtdSer synthesis induced by CaM antagonists was abolished in the presence of EGTA, indicating that the base exchange enzyme system responsible for PtdSer synthesis is regulated by CaM provided that Ca2+ is present.	Egtazic Acid	142-146	calmodulin 1	Homo sapiens	93-96
7617129-5	1995	Exposure of cultures to high K+ (56 mM) in the medium induced a ten-fold increase in basal CRH release which was completely abolished in a Ca(2+)-free medium containing 2 mM EGTA.	Egtazic Acid	174-178	corticotropin releasing hormone	Homo sapiens	91-94
7537700-2	1995	Addition of the extracellular Ca2+ chelator EGTA and the intracellular Ca2+ chelator BAPTA/AM 30 s after TRAP allowed platelet aggregation and the association of pp125FAK, pp60Src, CDC42Hs and Rap1B with the cytoskeleton, but prevented their dissociation from the cytoskeleton.	Egtazic Acid	44-48	protein tyrosine kinase 2	Homo sapiens	162-170
7537700-2	1995	Addition of the extracellular Ca2+ chelator EGTA and the intracellular Ca2+ chelator BAPTA/AM 30 s after TRAP allowed platelet aggregation and the association of pp125FAK, pp60Src, CDC42Hs and Rap1B with the cytoskeleton, but prevented their dissociation from the cytoskeleton.	Egtazic Acid	44-48	cell division cycle 42	Homo sapiens	181-188
7537700-2	1995	Addition of the extracellular Ca2+ chelator EGTA and the intracellular Ca2+ chelator BAPTA/AM 30 s after TRAP allowed platelet aggregation and the association of pp125FAK, pp60Src, CDC42Hs and Rap1B with the cytoskeleton, but prevented their dissociation from the cytoskeleton.	Egtazic Acid	44-48	RAP1B, member of RAS oncogene family	Homo sapiens	193-198
7718893-7	1995	Measurement of EGTA-resistant gelsolin/actin complexes in HL-60 cells shows that 95% to 100% of complexes exist in the TSF-actin pool only.	Egtazic Acid	15-19	gelsolin	Homo sapiens	30-38
7492943-7	1995	When the intact cells were treated with Ca(2+)-free, EGTA containing physiological saline solution, the membrane bound conventional PKC alpha (cPKC alpha) was greatly reduced and cytosolic cPKC alpha was only slightly increased.	Egtazic Acid	53-57	protein kinase C, alpha	Mus musculus	132-141
7537492-5	1995	On the other hand, the presence of EGTA or 100 microM quinacrine, an inhibitor of PLA2, during treatment of plasma membranes with PLA2 inhibited their fusogenic activity, suggesting the importance of activation of PLA2.	Egtazic Acid	35-39	phospholipase A2 group IB	Rattus norvegicus	82-86
7537492-5	1995	On the other hand, the presence of EGTA or 100 microM quinacrine, an inhibitor of PLA2, during treatment of plasma membranes with PLA2 inhibited their fusogenic activity, suggesting the importance of activation of PLA2.	Egtazic Acid	35-39	phospholipase A2 group IB	Rattus norvegicus	130-134
7537492-5	1995	On the other hand, the presence of EGTA or 100 microM quinacrine, an inhibitor of PLA2, during treatment of plasma membranes with PLA2 inhibited their fusogenic activity, suggesting the importance of activation of PLA2.	Egtazic Acid	35-39	phospholipase A2 group IB	Rattus norvegicus	130-134
7713926-11	1995	Inhibition by EGTA and activation by Ca2+ indicated PC1/3 and PC2 as Ca(2+)-dependent proteases.	Egtazic Acid	14-18	proprotein convertase subtilisin/kexin type 1	Bos taurus	52-57
7713904-5	1995	Both in intact cells and in an acellular system, the increase of PtdSer synthesis induced by CaM antagonists was abolished in the presence of EGTA, indicating that the base exchange enzyme system responsible for PtdSer synthesis is regulated by CaM provided that Ca2+ is present.	Egtazic Acid	142-146	calmodulin 1	Homo sapiens	245-248
7713926-11	1995	Inhibition by EGTA and activation by Ca2+ indicated PC1/3 and PC2 as Ca(2+)-dependent proteases.	Egtazic Acid	14-18	proprotein convertase subtilisin/kexin type 2	Bos taurus	62-65
7723744-4	1995	In contrast, chelation of extracellular Ca2+ by ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) reduced formation of inositol phosphates by G protein receptor (thrombin)- and tyrosine kinase (Fc receptor and peroxovanadate)-regulated pathways.	Egtazic Acid	48-117	coagulation factor II, thrombin	Homo sapiens	189-197
7723744-4	1995	In contrast, chelation of extracellular Ca2+ by ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) reduced formation of inositol phosphates by G protein receptor (thrombin)- and tyrosine kinase (Fc receptor and peroxovanadate)-regulated pathways.	Egtazic Acid	119-123	coagulation factor II, thrombin	Homo sapiens	189-197
7781712-4	1995	In Ca(2+)-free solution containing 0.2 mM EGTA, neuropeptide Y did not change [Ca2+]cyt and tension, whereas U46619 transiently increased both of them.	Egtazic Acid	42-46	neuropeptide Y	Canis lupus familiaris	48-62
7702635-4	1995	In both cases, the alteration of CaM content in SPM occurred in the EGTA-dissociable pool of CaM (77% of total membrane CaM); the EGTA-nondissociable pool (23% of total CaM) was not affected.	Egtazic Acid	68-72	calmodulin 1	Rattus norvegicus	33-36
7702635-4	1995	In both cases, the alteration of CaM content in SPM occurred in the EGTA-dissociable pool of CaM (77% of total membrane CaM); the EGTA-nondissociable pool (23% of total CaM) was not affected.	Egtazic Acid	68-72	calmodulin 1	Rattus norvegicus	93-96
7702635-4	1995	In both cases, the alteration of CaM content in SPM occurred in the EGTA-dissociable pool of CaM (77% of total membrane CaM); the EGTA-nondissociable pool (23% of total CaM) was not affected.	Egtazic Acid	68-72	calmodulin 1	Rattus norvegicus	93-96
7878063-5	1995	However, when external EGTA was used to blunt agonist-stimulated Ca2+ influx, 125I efflux was still increased in response to Ang II and ATP.	Egtazic Acid	23-27	angiotensinogen	Rattus norvegicus	125-131
7702635-4	1995	In both cases, the alteration of CaM content in SPM occurred in the EGTA-dissociable pool of CaM (77% of total membrane CaM); the EGTA-nondissociable pool (23% of total CaM) was not affected.	Egtazic Acid	68-72	calmodulin 1	Rattus norvegicus	93-96
7702635-4	1995	In both cases, the alteration of CaM content in SPM occurred in the EGTA-dissociable pool of CaM (77% of total membrane CaM); the EGTA-nondissociable pool (23% of total CaM) was not affected.	Egtazic Acid	130-134	calmodulin 1	Rattus norvegicus	33-36
7900771-3	1995	pHi was varied by using electrode solutions with pH at 6.8, 7.3, or 7.8, and Ca2+ activity was buffered at 100 nM with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid.	Egtazic Acid	119-188	glucose-6-phosphate isomerase	Rattus norvegicus	0-3
7772573-8	1995	Furthermore, the BK-induced [45Ca] uptake was inhibited by EGTA and PMA.	Egtazic Acid	59-63	kininogen 1	Homo sapiens	17-19
7738119-10	1995	Permeabilization of L6 cells with digitonin in the presence of 5 mM EGTA led to a release of annexin VII from the cells, which paralleled the loss of cytosolic lactate dehydrogenase (LDH) at low detergent concentrations (50 microM).	Egtazic Acid	68-72	annexin A7	Homo sapiens	93-104
7819250-6	1995	In EGTA, the polarization parameter (PEGTA) of sTnC4.W is greater than that of cardiac TnC, and the cardiac PEGTA value is closer to the activated PCa.	Egtazic Acid	3-7	tenascin C	Homo sapiens	48-51
7840141-6	1995	Experiments with ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid demonstrated that activation of Thap-sensitive PLA2 and 5-LO requires the influx of Ca2+.	Egtazic Acid	17-86	phospholipase A2 group IB	Homo sapiens	134-138
7585989-5	1995	This binding was Ca2+ dependent, but gelsolin was not removed after subsequent addition of EGTA.	Egtazic Acid	91-95	gelsolin	Gallus gallus	37-45
7606806-5	1995	Actin pools were measured by NBDphallacidin binding and by gel scans and expressed relative to basal; gelsolin-actin interactions were measured as change in the amount of EGTA-resistant gelsolin:actin (G:A) complexes and by immunoblot quantification of gelsolin in actin pools.	Egtazic Acid	171-175	gelsolin	Homo sapiens	102-110
7606806-5	1995	Actin pools were measured by NBDphallacidin binding and by gel scans and expressed relative to basal; gelsolin-actin interactions were measured as change in the amount of EGTA-resistant gelsolin:actin (G:A) complexes and by immunoblot quantification of gelsolin in actin pools.	Egtazic Acid	171-175	gelsolin	Homo sapiens	186-194
7606806-5	1995	Actin pools were measured by NBDphallacidin binding and by gel scans and expressed relative to basal; gelsolin-actin interactions were measured as change in the amount of EGTA-resistant gelsolin:actin (G:A) complexes and by immunoblot quantification of gelsolin in actin pools.	Egtazic Acid	171-175	gelsolin	Homo sapiens	186-194
7606806-6	1995	In basal PMNs, 33% of PMN gelsolin is bound in 1:1 EGTA-resistant G:A complexes and TSF and TIF retain 30% and 0% of PMN gelsolin, respectively.	Egtazic Acid	51-55	gelsolin	Homo sapiens	26-34
7606806-8	1995	At maximum change (60 seconds), total F-actin (TIF + TSF) and TSF decrease and TIF increases by 25%; gelsolin is bound to both TSF and TIF (35% of total gelsolin in each pool), and 1:1 EGTA-resistant G:A complexes increase from 33% to 70%.	Egtazic Acid	185-189	gelsolin	Homo sapiens	101-109
7758749-0	1995	EGTA-resistant binding of annexin V to platelet membranes can be induced by physiological calcium concentrations.	Egtazic Acid	0-4	annexin A5	Homo sapiens	26-35
7588373-3	1995	5 mM EGTA significantly reduced basal and stimulated 20-DHP secretion, although significant ACTH stimulation still remained.	Egtazic Acid	5-9	dihydropyrimidinase	Mus musculus	56-59
8588483-2	1995	In the absence of Ca2+ (addition of 1 mM EGTA) the Km of ICDH for DL-isocitrate was 143 microM, and in the presence of about 10 microM Ca2+ (EGTA-Ca2+ buffer) it was decreased to 55 microM.	Egtazic Acid	141-145	carbonic anhydrase 2	Oryctolagus cuniculus	135-138
8588483-2	1995	In the absence of Ca2+ (addition of 1 mM EGTA) the Km of ICDH for DL-isocitrate was 143 microM, and in the presence of about 10 microM Ca2+ (EGTA-Ca2+ buffer) it was decreased to 55 microM.	Egtazic Acid	141-145	carbonic anhydrase 2	Oryctolagus cuniculus	135-138
7829602-5	1995	TGF alpha induced an increase in the intracellular Ca2+ concentration in amnion cells, and this increase was significantly reduced when the cells were incubated with cobalt chloride (a Ca2+ channel blocker; 2.5 mmol/L) or EGTA (a Ca2+ chelator; 5 mmol/L).	Egtazic Acid	222-226	transforming growth factor alpha	Homo sapiens	0-9
7829602-6	1995	TGF alpha enhanced PGE2 production, and this increase was significantly inhibited when the cells were incubated with indomethacin (a cyclooxygenase inhibitor; 10 mumol/L), cobalt chloride (2.5 mmol/L), or EGTA (5 mmol/L).	Egtazic Acid	205-209	transforming growth factor alpha	Homo sapiens	0-9
7479295-6	1995	The stimulating effect of PTH (10(-8) M) on osteoclast-like cell formation was clearly weakened (about 50%) in the presence of EGTA (1.0 mM) or dibucaine (10(-5) M).	Egtazic Acid	127-131	parathyroid hormone	Mus musculus	26-29
7528243-5	1995	Quantitative analysis of TGF-beta 1 mRNA expression at 4 h after treatment with trypsin, EGTA, or cytochalasin C showed increases of 2.6-, 3.3-, and 2.6-fold, respectively.	Egtazic Acid	89-93	transforming growth factor beta 1	Homo sapiens	25-35
7533909-4	1994	Rapid and pronounced rundown of responses to GABA during whole-cell patch clamp recordings was overcome by the inclusion of EGTA in the pipette solution, indicating a possible role for calcium-dependent processes in the functional regulation of this GABA receptor.	Egtazic Acid	124-128	Resistant to dieldrin	Drosophila melanogaster	250-263
7803518-7	1994	In cells in which external calcium was reduced to less than 1 microM by the addition of EGTA, ET-1 signals were completely inhibited by 4-6 microM U-73122 and the IC50 was 0.8 microM.	Egtazic Acid	88-92	endothelin 1	Rattus norvegicus	94-98
8745062-8	1995	The stimulating effect of TGF-beta was markedly weakened by the presence of EGTA (0.5 mM), a chelator of Ca2+.	Egtazic Acid	76-80	transforming growth factor, beta 1	Mus musculus	26-34
7798265-10	1994	The Ca(2+)-dependent reassociation of p50 with the acrosomal apical segments was reversed by the addition of 2.0 mM EGTA, indicating that p50 binding is dependent on free Ca2+ concentrations.	Egtazic Acid	116-120	neuronal pentraxin-2	Cavia porcellus	38-41
7798265-10	1994	The Ca(2+)-dependent reassociation of p50 with the acrosomal apical segments was reversed by the addition of 2.0 mM EGTA, indicating that p50 binding is dependent on free Ca2+ concentrations.	Egtazic Acid	116-120	neuronal pentraxin-2	Cavia porcellus	138-141
7989321-7	1994	When the concentration of free Ca2+ ([Ca2+]i) was set to approximately 15 nM with 1.1 or 11 mM EGTA, a "slow"Ca2+ buffer, 10 nM C5a induced a large GkOR (11 nS at 1.1 mM EGTA versus 13.4 nS at 11 mM EGTA).	Egtazic Acid	95-99	hemolytic complement	Mus musculus	128-131
7989321-7	1994	When the concentration of free Ca2+ ([Ca2+]i) was set to approximately 15 nM with 1.1 or 11 mM EGTA, a "slow"Ca2+ buffer, 10 nM C5a induced a large GkOR (11 nS at 1.1 mM EGTA versus 13.4 nS at 11 mM EGTA).	Egtazic Acid	170-174	hemolytic complement	Mus musculus	128-131
7989321-7	1994	When the concentration of free Ca2+ ([Ca2+]i) was set to approximately 15 nM with 1.1 or 11 mM EGTA, a "slow"Ca2+ buffer, 10 nM C5a induced a large GkOR (11 nS at 1.1 mM EGTA versus 13.4 nS at 11 mM EGTA).	Egtazic Acid	170-174	hemolytic complement	Mus musculus	128-131
7705961-3	1994	Supernatants collected from macrophages treated with cisplatin and EGTA, nifedipine, TMB-8 or W-7 demonstrated decreased tumor necrosis factor (TNF) and interleukin-1 (IL-1) activity in comparison to supernatants collected from macrophages treated with cisplatin alone.	Egtazic Acid	67-71	tumor necrosis factor	Mus musculus	121-142
7946396-7	1994	Smooth muscle phosphatase activity was estimated by the rate of decline in peak light chain phosphorylation, while myosin light chain kinase was inhibited indirectly with trifluoperazine, with EGTA, or directly by a synthetic peptide inhibitor.	Egtazic Acid	193-197	myosin light chain kinase	Canis lupus familiaris	115-140
7750984-6	1994	Genistein, TMB-8 and EGTA completely inhibited LAK induction; however, the calcium channel blocker and chelator did not prevent the protein tyrosine phosphorylation.	Egtazic Acid	21-25	alpha kinase 1	Homo sapiens	47-50
7705961-3	1994	Supernatants collected from macrophages treated with cisplatin and EGTA, nifedipine, TMB-8 or W-7 demonstrated decreased tumor necrosis factor (TNF) and interleukin-1 (IL-1) activity in comparison to supernatants collected from macrophages treated with cisplatin alone.	Egtazic Acid	67-71	tumor necrosis factor	Mus musculus	144-147
7705961-3	1994	Supernatants collected from macrophages treated with cisplatin and EGTA, nifedipine, TMB-8 or W-7 demonstrated decreased tumor necrosis factor (TNF) and interleukin-1 (IL-1) activity in comparison to supernatants collected from macrophages treated with cisplatin alone.	Egtazic Acid	67-71	interleukin 1 complex	Mus musculus	153-172
7882138-3	1994	In addition, this cGMP generation was abrogated in the presence of either a Ca2+ chelator, EGTA, or a calcium/calmodulin inhibitor, W7, suggesting that IL-4 stimulates the constitutive NOS (cNOS).	Egtazic Acid	91-95	interleukin 4	Homo sapiens	152-156
7700024-8	1994	Inhibition of the intracellular release by preincubating vascular smooth muscle cells with thapsigargin (10(-5) M) also partially inhibited the effect of angiotensin II (Ang II) on [Ca++]n. However, combined EGTA and thapsigargin abolished both the rise in [Ca++]c and the surge in [Ca++]n. The protein kinase C inhibitors staurosporine (5 x 10(-8) M) and H7 (10(-7) M) had no effect on the Ang II-mediated increases in [Ca++]c and [Ca++]n. Our results demonstrate that the angiotensin II-induced increase in [Ca++]c is rapidly followed by a rise in [Ca++]n. This effect on [Ca++]n is not mediated by an angiotensin II-induced generation of IP3 or activation of protein kinases, but rather seems to depend on an increase in [Ca++]c.	Egtazic Acid	208-212	angiotensinogen	Rattus norvegicus	154-168
7700024-8	1994	Inhibition of the intracellular release by preincubating vascular smooth muscle cells with thapsigargin (10(-5) M) also partially inhibited the effect of angiotensin II (Ang II) on [Ca++]n. However, combined EGTA and thapsigargin abolished both the rise in [Ca++]c and the surge in [Ca++]n. The protein kinase C inhibitors staurosporine (5 x 10(-8) M) and H7 (10(-7) M) had no effect on the Ang II-mediated increases in [Ca++]c and [Ca++]n. Our results demonstrate that the angiotensin II-induced increase in [Ca++]c is rapidly followed by a rise in [Ca++]n. This effect on [Ca++]n is not mediated by an angiotensin II-induced generation of IP3 or activation of protein kinases, but rather seems to depend on an increase in [Ca++]c.	Egtazic Acid	208-212	angiotensinogen	Rattus norvegicus	170-176
7996447-6	1994	In the absence of external Ca++ (with 0.5 mM EGTA), ET-1 induced only a transient increase in [Ca++]i, which was inhibited by an inhibitor of Ca+(+)-ATPase in endoplasmic reticulum, 1 microM thapsigargin.	Egtazic Acid	45-49	endothelin-1	Oryctolagus cuniculus	52-56
7977830-4	1994	When patch pipettes contained 0.4-0.8 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, voltage-clamp steps over the range -20 to +50 mV activated an inward calcium current (ICa) and a Ca(2+)-activated chloride current [ICl(Ca)].	Egtazic Acid	41-110	calcium voltage-gated channel subunit alpha1 C	Canis lupus familiaris	198-201
7882138-3	1994	In addition, this cGMP generation was abrogated in the presence of either a Ca2+ chelator, EGTA, or a calcium/calmodulin inhibitor, W7, suggesting that IL-4 stimulates the constitutive NOS (cNOS).	Egtazic Acid	91-95	nitric oxide synthase 3	Homo sapiens	172-188
7882138-3	1994	In addition, this cGMP generation was abrogated in the presence of either a Ca2+ chelator, EGTA, or a calcium/calmodulin inhibitor, W7, suggesting that IL-4 stimulates the constitutive NOS (cNOS).	Egtazic Acid	91-95	nitric oxide synthase 3	Homo sapiens	190-194
7893968-5	1994	When extracellular calcium was chelated by EGTA, or when intracellular calpain was inhibited by the cell-permeable cysteine-protease inhibitor, E64d, the processing of 33 kDa IL-1 alpha was significantly blocked, the release of 33 kDa IL-1 alpha being unchanged.	Egtazic Acid	43-47	interleukin 1 alpha	Homo sapiens	175-185
7987541-7	1994	The EGTA extract contained a higher proportion of casein and lactoferrin, whereas transferrin was predominantly in the medium.	Egtazic Acid	4-8	lactotransferrin	Mus musculus	61-72
7870198-8	1994	Calcium supplementation to the cells during the treatment with EGTA restored the SP-potentiation of VP-16-induced differentiation.	Egtazic Acid	63-67	host cell factor C1	Homo sapiens	100-105
7521366-7	1994	Because the second peak of MBP kinase activity (like the first) was active in the absence of added calcium and in the presence of 2 mM EGTA, it appears to be a type II, calcium-independent isoform of PKC.	Egtazic Acid	135-139	myelin basic protein	Homo sapiens	27-30
7824068-6	1994	The dephosphorylation of tau induced by the proton-ionophores appeared to be calcium-dependent since the effect was blocked by EGTA.	Egtazic Acid	127-131	microtubule-associated protein tau	Rattus norvegicus	25-28
8063817-3	1994	EGTA, a specific chelator of calcium, was able to completely block calcium-induced p62 phosphorylation, even after using conditioned medium from calcium-treated keratinocytes.	Egtazic Acid	0-4	nucleoporin 62	Mus musculus	83-86
8049209-3	1994	The RYR fusion protein PC28 (residues 2937-3225) bound calmodulin in the presence of EGTA and Ca2+, while RYR fusion protein PC26 (residues 3546-3655) exhibited strong calmodulin binding at 10 microM Ca2+.	Egtazic Acid	85-89	ryanodine receptor 1	Homo sapiens	4-7
7884809-8	1994	However, when Ca2+ was removed from the efflux buffer and replaced with EGTA, peak thrombin-stimulated 125I efflux remained unchanged.	Egtazic Acid	72-76	coagulation factor II, thrombin	Homo sapiens	83-91
7999692-7	1994	The addition of a Ca2+ channel blocker (cobalt) or a Ca2+ chelator (EGTA) into the culture medium inhibited intracellular Ca2+ mobilisation and PGE2 production induced by EGF.	Egtazic Acid	68-72	epidermal growth factor	Homo sapiens	171-174
7999692-8	1994	The analysis of cell cycles showed that EGF induced the initiation of DNA synthesis and that the addition of cobalt or EGTA into the culture medium inhibited EGF-induced DNA synthesis.	Egtazic Acid	119-123	epidermal growth factor	Homo sapiens	158-161
7923609-5	1994	This shear stress-induced actin depolymerization was completely blocked by chelation of extracellular Ca2+ with EGTA and partially inhibited by intracellular Ca2+ chelation with the tetraacetoxymethyl ester of BAPTA (BAPTA/AM).	Egtazic Acid	112-116	carbonic anhydrase 2	Homo sapiens	102-105
7923609-8	1994	Moreover, shear stress-induced ET-1 gene expression was inhibited by EGTA, BAPTA/AM, and staurosporine to a degree similar to the inhibition of actin depolymerization.	Egtazic Acid	69-73	endothelin 1	Homo sapiens	31-35
7524475-5	1994	PTP in response to a threshold shear stress of 0.3 mN/cm2 (30 dyn/cm2) was enhanced in most cases by exogenous purified human vWF, and PTP in response to a pathological shear stress of 0.9 mN/cm2 (90 dyn/cm2) was inhibited in some cases by inhibiting vWF binding to GP Ib or GP IIb-IIIa, or by inhibiting Ca2+ responses with extracellular EGTA.	Egtazic Acid	339-343	protein tyrosine phosphatase receptor type U	Homo sapiens	0-3
7529007-3	1994	The bound CEA is eluted by ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N",-tetraacetic acid and monitored by radioactivity.	Egtazic Acid	27-97	CEA cell adhesion molecule 3	Homo sapiens	10-13
7519434-4	1994	iNOS activity, measured by conversion of [14C]arginine to [14C]citrulline in the presence of 1 mM EGTA, was higher than 100 pmol/min/mg protein in early passages of iNOS-transfected cells but decreased with cell subculturing.	Egtazic Acid	98-102	nitric oxide synthase 2	Homo sapiens	0-4
7518362-7	1994	Pretreatment with L-NMMA or EGTA significantly inhibited the IL-6-induced early elevation of cGMP.	Egtazic Acid	28-32	interleukin 6	Gallus gallus	61-65
7518362-10	1994	On the other hand, 24-hour exposure to IL-6 also increased the levels of cGMP (159.0 +/- 22.8% of the control value) regardless of pretreatment with EGTA.	Egtazic Acid	149-153	interleukin 6	Gallus gallus	39-43
27519868-7	1994	The EGTA extract contained a higher proportion of casein and lactoferrin, whereas transferrin was predominately in the medium.	Egtazic Acid	4-8	lactotransferrin	Mus musculus	61-72
7921598-20	1994	Contraction induced by ET-1 was virtually abolished in Ca2+-free medium containing 0.1 mM EGTA, indicating that this response was dependent upon the influx of extracellular Ca2 .Contraction was inhibited by about 50% in the presence of nicardipine (1 MicroM), indicating that a significant component of this response was mediated via the activation of L-type Ca2+ channels.6.	Egtazic Acid	90-94	endothelin 1	Homo sapiens	23-27
7983186-5	1994	The 105 kDa polypeptide, solubilized from liver homogenates with the addition of ATP, co-sediments with F-actin, co-purifies with calmodulin, and binds calmodulin in the presence of EGTA.	Egtazic Acid	182-186	calmodulin 1	Rattus norvegicus	152-162
8038217-4	1994	The effect of melittin and calcium ionophore A23187 on EGF-dependent protein tyrosine phosphorylation was abolished by treatment of cells with the calcium chelator EGTA.	Egtazic Acid	164-168	epidermal growth factor	Mus musculus	55-58
7981659-3	1994	Hydrophobic interactions of calretinin were partially Ca(2+)-dependent since 1/3 of bound protein was released from the resins by EGTA under varied conditions.	Egtazic Acid	130-134	calbindin 2	Rattus norvegicus	28-38
8027182-10	1994	Moreover, the two adhesion systems could be differentially modulated since short treatment with the Ca2+ chelator EGTA, disrupted the cadherin junctions leaving PECAM-1 apparently intact.	Egtazic Acid	114-118	platelet and endothelial cell adhesion molecule 1	Homo sapiens	161-168
8025959-4	1994	The phagocytosis of both nonstimulated and PAF-stimulated macrophages was suppressed in Ca(2+)-free ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid-containing solution, but the phagocytosis was enhanced by PAF even in this solution.	Egtazic Acid	100-164	patchy fur	Mus musculus	43-46
7798169-3	1994	The addition of S100 to the mixture of calponin and F-actin caused the removal of calponin from actin filaments in the presence of Ca2+ but not in the presence of EGTA or Zn2+.	Egtazic Acid	163-167	S100 calcium binding protein B	Homo sapiens	16-20
7973829-4	1994	To the contrast, decreased Ca2+ concentration in medium/EGTA/verapamil had inhibitory effect on progesterone production in the presence of hCG.	Egtazic Acid	56-60	hypertrichosis 2 (generalised, congenital)	Homo sapiens	139-142
7965011-10	1994	GCl(V) was blocked by bath application of 100 microM zinc (Zn2+), but not when 1-6 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) or bis-(o-aminophenoxy)-N,N,N",N"-tetraacetic acid (BAPTA) were present in the electrode solution.	Egtazic Acid	157-161	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	0-3
7515932-6	1994	Treatment of CD4 wild-type transfected cells with either anti-CD45 mAb, EGTA, or PMA rapidly restored the cells to basal levels of intracellular calcium.	Egtazic Acid	72-76	CD4 molecule	Homo sapiens	13-16
8031848-4	1994	Thrombin stimulation also induces the association of annexin V (11.0 +/- 4.6% of the total) with the membrane in a manner which requires prolonged treatment with EGTA for its release from the membrane.	Egtazic Acid	162-166	coagulation factor II, thrombin	Homo sapiens	0-8
8031848-4	1994	Thrombin stimulation also induces the association of annexin V (11.0 +/- 4.6% of the total) with the membrane in a manner which requires prolonged treatment with EGTA for its release from the membrane.	Egtazic Acid	162-166	annexin A5	Homo sapiens	53-62
8031850-6	1994	Basal or apical+basal EGTA addition induced substantial internalisation of uvomorulin with some cellular redistribution of the perijunctional actin ring and desmosomes and gaps in ZO-1 location between adjacent cells.	Egtazic Acid	22-26	cadherin 1	Canis lupus familiaris	75-85
8018695-6	1994	Endogenous calmodulin was somewhat resistant to removal and could be detected with immunoblotting after multiple washes of the membrane preparation with EDTA or EGTA.	Egtazic Acid	161-165	calmodulin-1	Salmo salar	11-21
8207426-2	1994	Chelation of extracellular Ca2+ with EGTA or inhibition of Ca2+ channels with Ni2+ showed that the plateau phase was dependent upon Ca2+ entry.	Egtazic Acid	37-41	carbonic anhydrase 2	Homo sapiens	27-30
8207426-3	1994	Furthermore, use of thapsigargin and EGTA to discharge and sequester Ca2+ from intracellular stores revealed that Ca2+ from this source was capable of supporting the peak phase of the InsP3 response.	Egtazic Acid	37-41	carbonic anhydrase 2	Homo sapiens	114-117
7816052-8	1994	The contraction to Ang II was abolished by EGTA but not by nitrendipine.	Egtazic Acid	43-47	angiogenin	Sus scrofa	19-22
8207206-8	1994	Removing extracellular Ca2+ with EGTA inhibited IRG2 induction; increasing intracellular calcium with the calcium ionophore A23187 led to enhanced levels of the IRG2 transcript.	Egtazic Acid	33-37	interferon-induced protein with tetratricopeptide repeats 3	Mus musculus	48-52
8204620-6	1994	Unlike calmodulin, calcineurin B interacts with calcineurin A in the presence of EGTA, and Ca2+ binding to calcineurin B stimulates native calcineurin up to only 10% of the maximum activity achieved with calmodulin.	Egtazic Acid	81-85	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	19-32
8188679-4	1994	MCP undergoes a Ca(2+)-induced conformational change as evidenced by different chymotryptic digest patterns in 0.2 mM CaCl2 compared with 2 mM EGTA.	Egtazic Acid	143-147	capping actin protein, gelsolin like	Homo sapiens	0-3
7816052-11	1994	CPA and thapsigargin induced contractions were abolished by exposure to EGTA for 1 h but short exposure of the cells to EGTA only modulated the CPA or thapsigargin induced increase in [Ca2+]i; Ang II induced increase in [Ca2+]i was not inhibited by 1 microM nitrendipine but was reduced significantly by a 30-60 sec exposure to EGTA.	Egtazic Acid	72-76	angiogenin	Sus scrofa	193-196
7816052-11	1994	CPA and thapsigargin induced contractions were abolished by exposure to EGTA for 1 h but short exposure of the cells to EGTA only modulated the CPA or thapsigargin induced increase in [Ca2+]i; Ang II induced increase in [Ca2+]i was not inhibited by 1 microM nitrendipine but was reduced significantly by a 30-60 sec exposure to EGTA.	Egtazic Acid	120-124	angiogenin	Sus scrofa	193-196
7816052-11	1994	CPA and thapsigargin induced contractions were abolished by exposure to EGTA for 1 h but short exposure of the cells to EGTA only modulated the CPA or thapsigargin induced increase in [Ca2+]i; Ang II induced increase in [Ca2+]i was not inhibited by 1 microM nitrendipine but was reduced significantly by a 30-60 sec exposure to EGTA.	Egtazic Acid	120-124	angiogenin	Sus scrofa	193-196
8180208-3	1994	Ca(2+)-calmodulin increases the rate of phosphorylation of dystrophin 12-fold relative to the EGTA control, while other protein kinase activators, cAMP and cGMP, have no effect.	Egtazic Acid	94-98	calmodulin 1	Homo sapiens	7-17
8180208-3	1994	Ca(2+)-calmodulin increases the rate of phosphorylation of dystrophin 12-fold relative to the EGTA control, while other protein kinase activators, cAMP and cGMP, have no effect.	Egtazic Acid	94-98	dystrophin	Homo sapiens	59-69
7515565-7	1994	Pretreatment of AG cells with barium (0.5 mM), tetraethylammonium (0.1 mM), charybdotoxin (100 nM), or ethylene glycol-bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (0.5 mM) blunted the ANP-induced decrease in [K+]i.	Egtazic Acid	103-171	natriuretic peptide A	Homo sapiens	193-196
8174638-2	1994	The results in this study suggest that beta 4 cleavage often occurs during or after cell lysis, where it was readily inhibitable by calcium chelators (EDTA, EGTA) and inhibitors of cysteine proteases (E64c, leupeptin).	Egtazic Acid	157-161	adaptor related protein complex 4 subunit beta 1	Homo sapiens	39-45
8163504-8	1994	The response is promoter-specific, dependent on Pit-1, and completely blocked by low concentrations of EGTA, consistent with a calcium-regulated pathway.	Egtazic Acid	103-107	POU class 1 homeobox 1	Rattus norvegicus	48-53
8161783-5	1994	The shear-dependent vWF change was not observed when purified vWF or normal plasma containing calcium chelator EGTA or EDTA was perfused.	Egtazic Acid	111-115	von Willebrand factor	Homo sapiens	20-23
8147852-2	1994	Increase of choline permeation by micromolar Ca2+, which refers to Ca2+ response, was lost when HSR vesicles were incubated overnight with EDTA or EGTA.	Egtazic Acid	147-151	HSR	Homo sapiens	96-99
8082657-5	1994	The gelsolin staining of myofibrils was EGTA-resistant; it persisted after glycerol extraction and extensive washing.	Egtazic Acid	40-44	gelsolin	Homo sapiens	4-12
8022100-7	1994	Glu at 10(-13) M led to a sustained rise in [Ca2+]i, which was completely blocked by external EGTA (5 mM, Ca-free solution).	Egtazic Acid	94-98	glucagon	Oryctolagus cuniculus	0-3
8157647-9	1994	Whereas Ca2+ generally stabilizes proteins to thermal denaturation, CPE was destabilized by Ca2+ and stabilized by low concentrations of EGTA.	Egtazic Acid	137-141	carboxypeptidase E	Homo sapiens	68-71
8058116-11	1994	In a nominally Ca2+ "free", EGTA-containing solution, a single supra-maximal concentration of Ang II (10(-6) mol/l) caused a transient contraction, also mediated by AT1-receptors.	Egtazic Acid	28-32	angiogenin	Rattus norvegicus	94-97
8058116-11	1994	In a nominally Ca2+ "free", EGTA-containing solution, a single supra-maximal concentration of Ang II (10(-6) mol/l) caused a transient contraction, also mediated by AT1-receptors.	Egtazic Acid	28-32	angiotensin II receptor, type 1a	Rattus norvegicus	165-168
8132611-5	1994	Treatment of F4-6 cells with EGTA led to a transient increase in c-myb mRNA with the same kinetics as the Ca2+ pump inhibitor-induced suppression, indicating that c-myb expression is bidirectionally regulated by changes in [Ca2+]i.	Egtazic Acid	29-33	MYB proto-oncogene, transcription factor	Homo sapiens	65-70
8130263-6	1994	However, the presence of EGTA completely abolished bradykinin stimulation and partially blocked the effect of interleukin 1 alpha (43% inhibition).	Egtazic Acid	25-29	kininogen 1	Homo sapiens	51-61
8130263-6	1994	However, the presence of EGTA completely abolished bradykinin stimulation and partially blocked the effect of interleukin 1 alpha (43% inhibition).	Egtazic Acid	25-29	interleukin 1 alpha	Homo sapiens	110-129
8130263-9	1994	These results suggest that following B2 receptor activation, cytosolic phospholipase A2 is stimulated by a rise in intracellular Ca2+ levels which are sensitive to the action of EGTA, whereas interleukin 1 alpha stimulation of cytosolic phospholipase A2 is mediated by a rise in intracellular Ca2+ from both EGTA-sensitive and resistant pools.	Egtazic Acid	178-182	phospholipase A2 group IB	Homo sapiens	71-87
8130263-9	1994	These results suggest that following B2 receptor activation, cytosolic phospholipase A2 is stimulated by a rise in intracellular Ca2+ levels which are sensitive to the action of EGTA, whereas interleukin 1 alpha stimulation of cytosolic phospholipase A2 is mediated by a rise in intracellular Ca2+ from both EGTA-sensitive and resistant pools.	Egtazic Acid	178-182	phospholipase A2 group IVA	Homo sapiens	61-87
8130263-9	1994	These results suggest that following B2 receptor activation, cytosolic phospholipase A2 is stimulated by a rise in intracellular Ca2+ levels which are sensitive to the action of EGTA, whereas interleukin 1 alpha stimulation of cytosolic phospholipase A2 is mediated by a rise in intracellular Ca2+ from both EGTA-sensitive and resistant pools.	Egtazic Acid	308-312	phospholipase A2 group IB	Homo sapiens	71-87
8130263-9	1994	These results suggest that following B2 receptor activation, cytosolic phospholipase A2 is stimulated by a rise in intracellular Ca2+ levels which are sensitive to the action of EGTA, whereas interleukin 1 alpha stimulation of cytosolic phospholipase A2 is mediated by a rise in intracellular Ca2+ from both EGTA-sensitive and resistant pools.	Egtazic Acid	308-312	interleukin 1 alpha	Homo sapiens	192-211
8130263-9	1994	These results suggest that following B2 receptor activation, cytosolic phospholipase A2 is stimulated by a rise in intracellular Ca2+ levels which are sensitive to the action of EGTA, whereas interleukin 1 alpha stimulation of cytosolic phospholipase A2 is mediated by a rise in intracellular Ca2+ from both EGTA-sensitive and resistant pools.	Egtazic Acid	308-312	phospholipase A2 group IVA	Homo sapiens	61-87
8132611-5	1994	Treatment of F4-6 cells with EGTA led to a transient increase in c-myb mRNA with the same kinetics as the Ca2+ pump inhibitor-induced suppression, indicating that c-myb expression is bidirectionally regulated by changes in [Ca2+]i.	Egtazic Acid	29-33	MYB proto-oncogene, transcription factor	Homo sapiens	163-168
8126008-5	1994	It was inhibited by [ethylenebis(oxyethylenenitrilo)]tetraacetic acid and beta-glycerophosphate at concentrations routinely used to stabilize p70S6K and p90rsk.	Egtazic Acid	20-69	ribosomal protein S6 kinase B1	Rattus norvegicus	142-148
8142372-1	1994	Occluded Ca2+ sites in the CrATP-ATPase complex are studied by first forming the complex in the presence of EGTA so that the sites can be occluded while vacant.	Egtazic Acid	108-112	dynein axonemal heavy chain 8	Homo sapiens	33-39
7510691-6	1994	In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).	Egtazic Acid	22-26	REL proto-oncogene, NF-kB subunit	Homo sapiens	199-204
7510691-6	1994	In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).	Egtazic Acid	22-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	206-209
7510691-6	1994	In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).	Egtazic Acid	22-26	nuclear factor kappa B subunit 1	Homo sapiens	211-214
7510691-6	1994	In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).	Egtazic Acid	22-26	DNA primase subunit 1	Homo sapiens	220-223
8117446-6	1994	Ca(2+)-free medium (2 mM EGTA) totally abolished the sustained response to PAF, but it only partially inhibited the transient response.	Egtazic Acid	25-29	PCNA-associated factor	Bos taurus	75-78
7906706-7	1994	Use of a quantitative DNA dot blot assay indicated that Thy-1-mediated thymocyte apoptosis was not blocked by RNA or protein synthesis inhibitors, EGTA, or by cyclosporin A, and differed, therefore, from "activation-driven cell death".	Egtazic Acid	147-151	thymus cell antigen 1, theta	Mus musculus	56-61
8109973-9	1994	Additionally, chelation of extracellular Ca2+ with EGTA minimized cell aggregation and also inhibited PAF receptor downregulation.	Egtazic Acid	51-55	PCNA clamp associated factor	Homo sapiens	102-105
8301352-9	1994	High concentrations of the calcium buffer EGTA in the presynaptic terminal slowed the buildup and decay of both [Ca2+]i and synaptic enhancement produced by stimulus trains.	Egtazic Acid	42-46	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	113-116
8294515-6	1994	Third, Myo2p coimmunoprecipitates with calmodulin in the presence of Ca2+ or EGTA.	Egtazic Acid	77-81	myosin 2	Saccharomyces cerevisiae S288C	7-12
8294515-6	1994	Third, Myo2p coimmunoprecipitates with calmodulin in the presence of Ca2+ or EGTA.	Egtazic Acid	77-81	calmodulin	Saccharomyces cerevisiae S288C	39-49
8286381-5	1994	The affinity and binding capacity of the channel protein in SR vesicles for the derivatized calmodulin (Rh-CaM) were determined by fluorescence anisotropy in the presence of (1) 1 mM EGTA, (2) 0.1 mM CaCl2, and (3) 0.1 mM CaCl2 plus 1 mM MgCl2.	Egtazic Acid	183-187	CaM5	Triticum aestivum	92-102
8286381-6	1994	In the presence of EGTA, Rh-CaM bound to the channel protein with a Kd of 8.6 +/- 0.8 nM and a Bmax of 229 +/- 7 pmol/mg, suggesting that calmodulin binds to the channel protein at [Ca2+] comparable to that in resting muscle.	Egtazic Acid	19-23	CaM5	Triticum aestivum	138-148
8135875-4	1994	Further, radioligand binding experiment, using a radiolabeled 1,5-benzothiazepine, showed that these compounds bound to Ca(2+)-calmodulin complex, but not to calmodulin in the presence of EGTA, suggesting that these 1,5-benzothiazepines are new calmodulin antagonists.	Egtazic Acid	188-192	calmodulin 1	Rattus norvegicus	127-137
8134615-4	1993	The CL production evoked by 6.5 nM of des(1-3)-IGF-I was inhibited significantly by both 0.25 and 1.0 nM of EGTA (Ca2+ chelator), or 10 microM nifedipine (Ca2+ channel inhibitor), pertussis toxin (0.05 and 1.0 micrograms/ml) or cholera toxin (5 micrograms/ml).	Egtazic Acid	108-112	insulin like growth factor 1	Homo sapiens	47-52
8275953-12	1994	Moreover, GnRH-induced release of FSH was suppressed to the same degree by 10(-10) M 3 alpha HP as by 10(-4) M EGTA.	Egtazic Acid	111-115	gonadotropin releasing hormone 1	Rattus norvegicus	10-14
8139399-4	1994	Cholesterol ester hydrolase was activated twofold by free calcium and Ca2+/calmodulin; this latter effect was blocked by the chelator ethylene-glycol-bis(beta-aminoethyl ether)N,N,N",N"-tetraacetic acid and the calmodulin antagonist trifluoperazine.	Egtazic Acid	134-202	calmodulin 1	Rattus norvegicus	75-85
7510323-4	1993	The mutation (fks1) also confers a slow growth phenotype which is partially suppressed by exogenously added Ca2+ and exacerbated by EGTA.	Egtazic Acid	132-136	1,3-beta-D-glucan synthase	Saccharomyces cerevisiae S288C	14-18
8241189-5	1993	Stopped-flow fluorescence kinetic analysis demonstrated that EGTA chelation of Ca2+ from CaM disrupted the MIANS.CaM-calponin complex at a rate of 1 s-1.	Egtazic Acid	61-65	calmodulin 1	Homo sapiens	113-116
8241189-5	1993	Stopped-flow fluorescence kinetic analysis demonstrated that EGTA chelation of Ca2+ from CaM disrupted the MIANS.CaM-calponin complex at a rate of 1 s-1.	Egtazic Acid	61-65	calmodulin 1	Homo sapiens	89-92
19912956-3	1993	KCl depolarization-induced release of NPY, but not basal release, was abolished by Ca(2+)-free/EGTA medium and was significantly reduced by cobalt.	Egtazic Acid	95-99	neuropeptide Y	Rattus norvegicus	38-41
8145166-19	1993	The first application of TRH to neurones perfused with Ca(2+)-free external solution containing 2 mM EGTA could induce ITRH but the TRH response diminished dramatically with successive applications.	Egtazic Acid	101-105	thyrotropin releasing hormone	Rattus norvegicus	25-28
8145166-19	1993	The first application of TRH to neurones perfused with Ca(2+)-free external solution containing 2 mM EGTA could induce ITRH but the TRH response diminished dramatically with successive applications.	Egtazic Acid	101-105	thyrotropin releasing hormone	Rattus norvegicus	120-123
8246968-6	1993	In vitro reconstitution experiments showed that c-Yes can be inactivated by preincubation with a Ca(2+)-supplemented cell extract and that this inhibition was reversed by the addition of EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid].	Egtazic Acid	187-191	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	48-53
8246968-6	1993	In vitro reconstitution experiments showed that c-Yes can be inactivated by preincubation with a Ca(2+)-supplemented cell extract and that this inhibition was reversed by the addition of EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid].	Egtazic Acid	193-262	YES proto-oncogene 1, Src family tyrosine kinase	Homo sapiens	48-53
8128438-5	1993	Stimulation of platelets with thrombin in the presence of EGTA resulted in a smaller luminescent signal than in the presence of Ca2+.	Egtazic Acid	58-62	coagulation factor II, thrombin	Homo sapiens	30-38
8224202-5	1993	The decrease in extracellular calcium by the addition of the calcium-chelating agent EGTA to the incubation medium caused an increase in PEPCK mRNA levels.	Egtazic Acid	85-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	137-142
7935356-1	1993	Agents, such as EGTA, thapsigargin, and ionophore A23187, that mobilize sequestered Ca2+ from the endoplasmic reticulum (ER) or dithiothreitol (DTT) that compromises the oxidizing environment of the organelle, disrupt early protein processing and inhibit translational initiation.	Egtazic Acid	16-20	carbonic anhydrase 2	Rattus norvegicus	84-87
7935356-6	1993	Alterations in eIF-2 alpha phosphorylation and translational activity in response to EGTA were reversed by addition of Ca2+ in excess of chelator while responses to DTT were reversible by washing.	Egtazic Acid	85-89	eukaryotic translation initiation factor 2A	Rattus norvegicus	15-26
7935356-6	1993	Alterations in eIF-2 alpha phosphorylation and translational activity in response to EGTA were reversed by addition of Ca2+ in excess of chelator while responses to DTT were reversible by washing.	Egtazic Acid	85-89	carbonic anhydrase 2	Rattus norvegicus	119-122
8408215-3	1993	We have recorded electron microscope images of negatively stained thin filaments containing caldesmon and tropomyosin which were isolated from chicken gizzard smooth muscle in EGTA.	Egtazic Acid	176-180	caldesmon 1	Gallus gallus	92-101
8134312-2	1993	The calcium chelator EGTA (2 mM) reduced the early peak and abolished the second phase of CCK release.	Egtazic Acid	21-25	cholecystokinin	Rattus norvegicus	90-93
8010076-1	1993	Membranes prepared from rabbit erythrocyte hemolyzed in isosmotic imidazole (151 mmol.L-1, pH 7.4) buffer showed an enhancement of calmodulin (CaM) activated Ca(2+)-ATPase activity compared with the membrane prepared in hypotonic imidazole (10 mmol.L-1, EGTA 1 mmol.L-1, pH 7.4) buffer.	Egtazic Acid	254-258	calmodulin	Oryctolagus cuniculus	131-141
8010076-1	1993	Membranes prepared from rabbit erythrocyte hemolyzed in isosmotic imidazole (151 mmol.L-1, pH 7.4) buffer showed an enhancement of calmodulin (CaM) activated Ca(2+)-ATPase activity compared with the membrane prepared in hypotonic imidazole (10 mmol.L-1, EGTA 1 mmol.L-1, pH 7.4) buffer.	Egtazic Acid	254-258	calmodulin	Oryctolagus cuniculus	143-146
8414495-9	1993	On the other hand, it was completely digested in the presence of EGTA, suggesting the possibility that the proto-Ret protein interacts with Ca2+ like cadherins.	Egtazic Acid	65-69	ret proto-oncogene	Mus musculus	113-116
8399354-7	1993	Thus, PDGF-induced PLA2 dependent AA release in Swiss 3T3 fibroblast is regulated by both PKC-dependent and -independent mechanisms, and is activated by high concentrations of free Ca2+ in the microenvironment beneath the plasma membrane during Ca2+ influx via plasma-membrane Ca2+ channels, despite buffering by EGTA of [Ca2+]i in the bulk cytoplasm of the cell.	Egtazic Acid	313-317	phospholipase A2 group IB	Homo sapiens	19-23
8229757-10	1993	Contraction induced by 10 nM PAF was inhibited when cells were incubated in Ca(++)-free medium with or without 2 mM EGTA or in a 1 mM Ca++ medium to which 100 nM nifedipine was added.	Egtazic Acid	116-120	PCNA clamp associated factor	Homo sapiens	29-32
8376387-7	1993	Recombinant SPC3 was inhibited most effectively by the thiol-reactive reagent p-hydroxymecuribenzoate and the heavy metal chelators EDTA and EGTA.	Egtazic Acid	141-145	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8232812-4	1993	In isolated middle cerebral arteries, ET-1 induced concentration-dependent contractions, which were equally inhibited in Ca(2+)-free medium (without or with ethylene glycol tetraacetic acid) and by the Ca2+ entry blocker nicardipine.	Egtazic Acid	157-189	endothelin-1	Capra hircus	38-42
8223566-7	1993	In marked contrast, EGTA completely blocked the Ca2+ response stimulated by C3a in neutrophils labeled with either Indo-1/AM or Fluo-3.	Egtazic Acid	20-24	complement C3	Homo sapiens	76-79
8379925-8	1993	Removal of extracellular Ca2+ with EGTA abolished the FMLP enhancement of uridine transport in a reversible manner, suggesting the involvement of Ca2+.	Egtazic Acid	35-39	formyl peptide receptor 1	Homo sapiens	54-58
8366076-14	1993	However, surprisingly, two of these short mutants filled each TnC slot under highly specific superloading conditions: one short molecule was taken up in EGTA solution, and the second molecule was captured and retained with Ca2+.	Egtazic Acid	153-157	tenascin	Oryctolagus cuniculus	62-65
7505065-4	1993	The following evidences point to a participation of CD41a in the adhesion of activated platelets to leukocytes: a) inhibition of adhesion by monoclonal antibodies (mab) raised toward CD41a, b) inhibition of adhesion by peptides such as RGDS and echistatin, c) inhibition of adhesion by dissociation of the CD41a complex with EGTA, and d) inhibition of rosette formation using platelets from a thrombasthenic patient which have almost no CD41a in the surface membrane but a normal expression of CD62.	Egtazic Acid	325-329	integrin subunit alpha 2b	Homo sapiens	52-56
8373359-8	1993	The effect of pancreastatin on [Ca2+]i was decreased by 50% when Ca2+ was omitted from the medium, and totally abolished when hepatocytes were depleted of internal Ca2+ stores by preincubation without Ca2+ and with 2 mM EGTA.	Egtazic Acid	220-224	chromogranin A	Sus scrofa	14-27
8103747-3	1993	This homologous C3 deposition was induced by serum containing Mg2+ and EGTA (Mg(2+)-EGTA serum) selectively on a P39 subline [P39(+)cells] having the capacity to form cell aggregates.	Egtazic Acid	71-75	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	113-116
8103747-3	1993	This homologous C3 deposition was induced by serum containing Mg2+ and EGTA (Mg(2+)-EGTA serum) selectively on a P39 subline [P39(+)cells] having the capacity to form cell aggregates.	Egtazic Acid	71-75	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	126-129
8103747-3	1993	This homologous C3 deposition was induced by serum containing Mg2+ and EGTA (Mg(2+)-EGTA serum) selectively on a P39 subline [P39(+)cells] having the capacity to form cell aggregates.	Egtazic Acid	84-88	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	113-116
8103747-3	1993	This homologous C3 deposition was induced by serum containing Mg2+ and EGTA (Mg(2+)-EGTA serum) selectively on a P39 subline [P39(+)cells] having the capacity to form cell aggregates.	Egtazic Acid	84-88	cyclin dependent kinase 5 regulatory subunit 2	Homo sapiens	126-129
8243798-12	1993	EGTA/albumin treatment, which enhanced activities at both P450scc and P45011 beta, presumably via increased NADPH, diminished this cross-competition.	Egtazic Acid	0-4	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	58-65
8255727-3	1993	CCh-evoked current oscillations were followed very closely by oscillations in intracellular free Ca2+ estimated from the Indo-1 signal, and were abolished by inclusion of EGTA in the pipette solution.	Egtazic Acid	171-175	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	97-100
8220891-7	1993	In the absence of extracellular calcium ions (with 0.1 mM EGTA), bradykinin (10 pM-10 microM) produced a uniform increase in [Ca2+]i from a basal level of 33 +/- 2 nM (n = 140) to approximately 180 nM in BTSM cells indicating an "all-or-nothing" release of intracellular calcium ions.	Egtazic Acid	58-62	kininogen 1	Bos taurus	65-75
8368264-6	1993	In the absence of extracellular Ca2+ (1 mM EGTA) ET-1 also elicited a Ca2+ peak, indicating participation of Ca2+ release from intracellular stores in the initial Ca2+ peak.	Egtazic Acid	43-47	endothelin 1	Mus musculus	49-53
8229086-4	1993	If Ca++ is removed from the culture medium through the addition of EGTA, expression of the nerve growth factor receptor and glial fibrillary acidic protein genes is inhibited but downregulation of the P(o) gene still occurs.	Egtazic Acid	67-71	nerve growth factor receptor	Rattus norvegicus	91-119
8394694-0	1993	Definition of the EGTA-independent interface involved in the serum gelsolin-actin complex.	Egtazic Acid	18-22	gelsolin	Homo sapiens	67-75
8394694-2	1993	In the presence of EGTA, the N-terminal domain of gelsolin is known to be involved.	Egtazic Acid	19-23	gelsolin	Homo sapiens	50-58
8229086-4	1993	If Ca++ is removed from the culture medium through the addition of EGTA, expression of the nerve growth factor receptor and glial fibrillary acidic protein genes is inhibited but downregulation of the P(o) gene still occurs.	Egtazic Acid	67-71	glial fibrillary acidic protein	Rattus norvegicus	124-155
8229086-5	1993	Explants cultured in medium containing EGTA are still capable of expressing nerve growth factor receptor if the medium is replaced by one containing Ca2+.	Egtazic Acid	39-43	nerve growth factor receptor	Rattus norvegicus	76-104
8333544-7	1993	In another series of experiments performed in the presence of ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid to deplete extracellular calcium, CCK-8 treatment still resulted in significant increases in cytosolic calcium; however, oscillations were abolished.	Egtazic Acid	62-131	cholecystokinin	Rattus norvegicus	166-169
8413932-13	1993	Corticotropin-releasing factor efflux produced by the second stimulation pulse was completely inhibited by perfusion with calcium-free medium containing calcium-chelating agent ethyleneglycol tetraacetic acid (10 mM).	Egtazic Acid	177-208	corticotropin releasing hormone	Rattus norvegicus	0-30
8234033-3	1993	Thyrotropin-releasing hormone markedly increased [3H]DA release and intracellular free calcium concentration ([Ca2+]i) in TIDA neurons, and its effect was abolished by treatment with EGTA (5 mM) or chlordiazepoxide, a specific TRH receptor antagonist (10 microM).	Egtazic Acid	183-187	thyrotropin releasing hormone	Rattus norvegicus	0-29
8234033-3	1993	Thyrotropin-releasing hormone markedly increased [3H]DA release and intracellular free calcium concentration ([Ca2+]i) in TIDA neurons, and its effect was abolished by treatment with EGTA (5 mM) or chlordiazepoxide, a specific TRH receptor antagonist (10 microM).	Egtazic Acid	183-187	thyrotropin releasing hormone	Rattus norvegicus	227-230
8101537-7	1993	Cholera toxin, CsA, or EGTA pretreatment also significantly inhibited their release of alpha-N-benzyloxycarbonyl-L-lysine-thiobenzylester-esterase activity suggesting that degranulation of CD4+ and CD8+ effectors may be a critical step in their redirected lysis of SRBC.	Egtazic Acid	23-27	CD4 molecule	Homo sapiens	189-192
8101537-7	1993	Cholera toxin, CsA, or EGTA pretreatment also significantly inhibited their release of alpha-N-benzyloxycarbonyl-L-lysine-thiobenzylester-esterase activity suggesting that degranulation of CD4+ and CD8+ effectors may be a critical step in their redirected lysis of SRBC.	Egtazic Acid	23-27	CD8a molecule	Homo sapiens	198-201
7686949-5	1993	Addition of the Ca2+ ionophore, ionomycin, increased CD20 phosphorylation both in activated B cells and in cells from the hairy cell line; addition of EGTA to either cell type decreased basal levels of CD20 phosphorylation.	Egtazic Acid	151-155	keratin 20	Homo sapiens	202-206
7685351-5	1993	In addition, among various phosphotyrosyl proteins isolated from EGTA extracts by adsorption onto an anti-phosphotyrosine antibody, annexin I was specifically recognized by Western blotting using a monoclonal anti-annexin I antibody, and displayed the same increase upon cell stimulation with angiotensin II.	Egtazic Acid	65-69	annexin A1	Rattus norvegicus	132-141
8390223-5	1993	Calmodulin stimulation was immediately reversed upon chelation of Ca2+ by ethylene glycol bis (beta-amino-ethyl ether) N,N"-tetraacetic acid consistent with a mechanism of activation involving a direct interaction of calmodulin with Ins(1,4,5)P3 3-kinase.	Egtazic Acid	74-140	calmodulin 1	Homo sapiens	0-10
8390223-5	1993	Calmodulin stimulation was immediately reversed upon chelation of Ca2+ by ethylene glycol bis (beta-amino-ethyl ether) N,N"-tetraacetic acid consistent with a mechanism of activation involving a direct interaction of calmodulin with Ins(1,4,5)P3 3-kinase.	Egtazic Acid	74-140	calmodulin 1	Homo sapiens	217-227
7684373-7	1993	The presence of EGTA had no effect on the Epo binding but completely inhibited the calcium increase, indicating that Epo stimulated the calcium influx from outside of the cells.	Egtazic Acid	16-20	erythropoietin	Rattus norvegicus	117-120
8595813-6	1993	The presence of EGTA or EDTA caused a 73% inhibition of PLA2 activity in ROS relative to the activity observed when no calcium was added.	Egtazic Acid	16-20	LOC104974671	Bos taurus	56-60
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Egtazic Acid	137-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	5-11
8500615-4	1993	Thus p59fyn could replace the calcium ionophore but not activation of protein kinase C. The activation by p59fyn plus PMA was blocked by EGTA and by the immunosuppressant drug cyclosporin A.	Egtazic Acid	137-141	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-112
8503851-3	1993	This release was reduced by chelation of intracellular Ca2+ with Quin-2 or by lowering the extracellular Ca2+ concentration in the medium with EGTA, presumably resulting in inhibition of phospholipase A2.	Egtazic Acid	143-147	phospholipase A2 group IB	Homo sapiens	187-203
8496152-2	1993	Treatment of the cells with 0.5-4 microM A23187 or 1-4 microM ionomycin induced a concentration-dependent decrease in c-myb mRNA; this decrease was abolished by EGTA.	Egtazic Acid	161-165	MYB proto-oncogene, transcription factor	Homo sapiens	118-123
8386174-5	1993	At pH below 6.0, gelsolin no longer requires Ca2+ for activity and severs actin filaments, binds two actin monomers, and nucleates filament formation in EGTA-containing solutions.	Egtazic Acid	153-157	gelsolin	Homo sapiens	17-25
8486928-3	1993	Most of these detected proteins are secreted in response to TCR-crosslinking (or to combined action of PMA and A231287), in an extracellular Ca(2+)-dependent manner and their appearance in supernatants was completely blocked by the addition of RNA synthesis or protein synthesis inhibitors or EGTA.	Egtazic Acid	293-297	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	60-63
8329674-6	1993	In low-Ca(2+)-EGTA media, there was an abrupt peak and rapid decline in SMC [Ca2+]i to 10(-8) M AII in AA and EA; the abrupt peaks were attenuated by the prior addition of dantrolene (5 x 10(-5) M) to the low-Ca(2+)-EGTA media.	Egtazic Acid	14-18	angiotensinogen	Rattus norvegicus	96-99
8473282-7	1993	The activation was sensitive to EGTA and cyclosporin A, indicating that p56lck functions at an early stage of the calcium-mediated pathway.	Egtazic Acid	32-36	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	72-78
8264711-3	1993	Addition of the Ca2+ chelator EGTA to the same medium buffered at pH 6.5 also induced sclerotic bodies, but in a more concentration-dependent fashion.	Egtazic Acid	30-34	carbonic anhydrase 2	Homo sapiens	16-19
8463316-6	1993	EGTA disrupts the CaM.MLCK, CaM.P-MLCK, and the CaM.CaD complexes at rates of 3.5 s-1, 6.5 s-1, and 13.5 s-1, respectively.	Egtazic Acid	0-4	CaM5	Triticum aestivum	18-21
8463316-6	1993	EGTA disrupts the CaM.MLCK, CaM.P-MLCK, and the CaM.CaD complexes at rates of 3.5 s-1, 6.5 s-1, and 13.5 s-1, respectively.	Egtazic Acid	0-4	CaM5	Triticum aestivum	28-31
8463316-6	1993	EGTA disrupts the CaM.MLCK, CaM.P-MLCK, and the CaM.CaD complexes at rates of 3.5 s-1, 6.5 s-1, and 13.5 s-1, respectively.	Egtazic Acid	0-4	CaM5	Triticum aestivum	28-31
8383691-5	1993	Extracellular Ca2+ chelation with 5 mM EGTA abolished the sustained increases in [Ca2+]i induced by either TRP-14 or alpha-thrombin.	Egtazic Acid	39-43	coagulation factor II, thrombin	Bos taurus	123-131
8388395-3	1993	In the presence of 1 mM Ca2+, thrombin- (0.1 U/ml) induced platelet aggregation and ATP release were inhibited by calyculin A, while this inhibitory effect was abolished in the absence of Ca2+ (EGTA 1 mM).	Egtazic Acid	194-198	coagulation factor II, thrombin	Homo sapiens	30-38
8454047-6	1993	Adding 1 mM EGTA to chelate extracellular Ca2+ inhibited [3H]PEt by approximately 31% and [14C]PEt by 17% after VP-stimulation.	Egtazic Acid	12-16	arginine vasopressin	Rattus norvegicus	112-114
7681399-4	1993	The effect of TNF was dose and time dependent, evident after 12 h and maximal at 48 h. The enhanced PAF-induced [Ca++]i rise was inhibited by the PAF receptor antagonist L-659,989 and EGTA, indicating receptor-dependent Ca++ influx.	Egtazic Acid	184-188	tumor necrosis factor	Homo sapiens	14-17
7681399-4	1993	The effect of TNF was dose and time dependent, evident after 12 h and maximal at 48 h. The enhanced PAF-induced [Ca++]i rise was inhibited by the PAF receptor antagonist L-659,989 and EGTA, indicating receptor-dependent Ca++ influx.	Egtazic Acid	184-188	PCNA clamp associated factor	Homo sapiens	100-103
7682220-8	1993	This stimulation is blocked by EGTA and the calmodulin antagonist W7, but not by protein kinase C inhibitors, suggesting the involvement of the calmodulin branch of the calcium messenger system.	Egtazic Acid	31-35	calmodulin 1	Rattus norvegicus	144-154
8468368-3	1993	Complete removal of extracellular Ca2+ using EGTA blocked DNA synthesis if Ca2+ was removed on the second day after EGF addition but not if Ca2+ was absent only on day 1.	Egtazic Acid	45-49	carbonic anhydrase 2	Rattus norvegicus	34-37
8468368-3	1993	Complete removal of extracellular Ca2+ using EGTA blocked DNA synthesis if Ca2+ was removed on the second day after EGF addition but not if Ca2+ was absent only on day 1.	Egtazic Acid	45-49	carbonic anhydrase 2	Rattus norvegicus	75-78
8468368-3	1993	Complete removal of extracellular Ca2+ using EGTA blocked DNA synthesis if Ca2+ was removed on the second day after EGF addition but not if Ca2+ was absent only on day 1.	Egtazic Acid	45-49	carbonic anhydrase 2	Rattus norvegicus	75-78
7679116-5	1993	We show that NF-ATp is dephosphorylated in cell lysates by a calcium-dependent process that is blocked by inclusion of EGTA or a specific peptide inhibitor of calcineurin in the cell lysis buffer.	Egtazic Acid	119-123	nuclear factor of activated T cells 1	Bos taurus	13-19
8387187-4	1993	Because PACAP-27 strongly elevated cytosolic calcium after the addition of 1 mM EGTA, PACAP released calcium from intracellular pools using NCI-N417 cells; similar results were obtained for SCLC cell line NCI-H345.	Egtazic Acid	80-84	adenylate cyclase activating polypeptide 1	Homo sapiens	8-13
8387187-4	1993	Because PACAP-27 strongly elevated cytosolic calcium after the addition of 1 mM EGTA, PACAP released calcium from intracellular pools using NCI-N417 cells; similar results were obtained for SCLC cell line NCI-H345.	Egtazic Acid	80-84	adenylate cyclase activating polypeptide 1	Homo sapiens	86-91
8483812-8	1993	The beneficial effects of PMSF and EGTA suggested that serine protease(s) and metalloproteases contribute to the observed anomalous pharmacological characteristics of AI and AIII, respectively.	Egtazic Acid	35-39	cell division cycle 34, ubiqiutin conjugating enzyme	Rattus norvegicus	55-70
7682535-11	1993	Cross-linking of CD5 or CD28 induces an early rise of cytoplasmic free calcium concentration ([Ca2+)]i) and both this rise and CD69 expression were inhibited by chelation of extracellular Ca2+ with ethyleneglycol-bis-(2-aminoethyl)-tetraacetate (EGTA).	Egtazic Acid	246-250	CD5 molecule	Homo sapiens	17-20
7682535-11	1993	Cross-linking of CD5 or CD28 induces an early rise of cytoplasmic free calcium concentration ([Ca2+)]i) and both this rise and CD69 expression were inhibited by chelation of extracellular Ca2+ with ethyleneglycol-bis-(2-aminoethyl)-tetraacetate (EGTA).	Egtazic Acid	246-250	CD28 molecule	Homo sapiens	24-28
7682535-11	1993	Cross-linking of CD5 or CD28 induces an early rise of cytoplasmic free calcium concentration ([Ca2+)]i) and both this rise and CD69 expression were inhibited by chelation of extracellular Ca2+ with ethyleneglycol-bis-(2-aminoethyl)-tetraacetate (EGTA).	Egtazic Acid	246-250	CD69 molecule	Homo sapiens	127-131
7678630-12	1993	Furthermore, stimulation with FMLP, in the presence of EGTA, depleted the calcium source responsible for the anti-IgE response.	Egtazic Acid	55-59	formyl peptide receptor 1	Homo sapiens	30-34
8478431-9	1993	This suggests that EGTA promotes phosphorylation of myosin by the activation of MLCK and not by inhibition of MLCP.	Egtazic Acid	19-23	myosin light chain kinase	Rattus norvegicus	80-84
8312569-6	1993	Pretreatment of cells with calcium-free medium, or with medium containing ethyleneglycol-bis-(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA) or verapamil, significantly blocked the reorganization of spectrin induced by Concanavalin A or the calcium ionophore A23187, and also prevented the release of IL-2 from these cells.	Egtazic Acid	74-137	interleukin 2	Mus musculus	305-309
8481099-5	1993	The accumulation of Cd2+ from the basolateral compartment occurred in two phases: a rapid, exponential phase that occurred in 1-2 h and coincided with a decrease in transepithelial resistance, and a slower, linear phase that continued for 6-8 h. The Cd2+ that accumulated during the rapid phase was easily removed by washing the cells in EGTA, indicating that most of it was bound to sites on the cell surface.	Egtazic Acid	338-342	CD2 molecule	Sus scrofa	20-23
8439991-6	1993	Secondly, in cells treated with 0.5 mM EGTA in Ca(2+)-free medium, the asparagine action on ODC induction was blocked but the inhibition could be reversed by the addition of Ca2+ to the medium.	Egtazic Acid	39-43	ornithine decarboxylase 1	Rattus norvegicus	92-95
8437103-4	1993	In contrast, the calcium-chelator, EGTA, and lanthanum, an inorganic compound that blocks voltage-sensitive calcium channels and Na(+)-Ca++ exchanger activity, enhanced anoxia-induced D-[3H]aspartate release.	Egtazic Acid	35-39	nascent polypeptide associated complex subunit alpha	Homo sapiens	129-137
8424767-12	1993	In fact, the inhibition of active Ca2+ uptake by excess EGTA, or lowering the P(i) concentration of the incubation system by dilution, caused the release of 45Ca2+ and [32P]P(i) from 45Ca2+ or [32P]P(i) pre-loaded brain microsomes.	Egtazic Acid	56-60	carbonic anhydrase 2	Rattus norvegicus	34-37
8428218-10	1993	Pretreatment with the 5-lipoxygenase inhibitor AA861 (20 microM) produced only a small (14 +/- 2%) inhibition of the [Ca2+]i response elicted by N6-cyclopentyladenosine (300 nM), in nominally Ca(2+)-free buffer containing 0.1 mM EGTA.	Egtazic Acid	229-233	polyunsaturated fatty acid 5-lipoxygenase	Mesocricetus auratus	22-36
8312569-6	1993	Pretreatment of cells with calcium-free medium, or with medium containing ethyleneglycol-bis-(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA) or verapamil, significantly blocked the reorganization of spectrin induced by Concanavalin A or the calcium ionophore A23187, and also prevented the release of IL-2 from these cells.	Egtazic Acid	139-143	interleukin 2	Mus musculus	305-309
1281157-7	1992	The purified calmodulin-independent isozyme was converted to a calmodulin-dependent isozyme by EDTA and EGTA.	Egtazic Acid	104-108	calmodulin 1	Rattus norvegicus	13-23
8101014-9	1993	When CK-BB is present in serum, the CK-B concentration is apparently lower using the Ektachem CK method than with use of the CK-MB slide, probably relating to the fact that chelator is omitted from the CK slide, while EGTA is supplied in the CK-MB slide.	Egtazic Acid	218-222	creatine kinase B	Homo sapiens	5-10
1471987-9	1992	However, EGTA also strongly decreased catalytic activity of cathepsin G, which is essential for platelet activation.	Egtazic Acid	9-13	cathepsin G	Homo sapiens	60-71
7678040-7	1993	The PLA2 effect was reversed by EGTA, the PLA2 inhibitor p-bromophenacyl bromide, and prolonged pretreatment with heat.	Egtazic Acid	32-36	phospholipase A2 group IB	Rattus norvegicus	4-8
21043888-7	1993	Our previous observations suggested that cathepsin G stimulates phospholipase C since the protease induces an elevation in [Ca(2+)]i in the presence of exogenous EGTA.	Egtazic Acid	162-166	cathepsin G	Homo sapiens	41-52
1472004-8	1992	Extracellular EGTA partially prevented this response, suggesting that activation of the C5a receptor promotes both the release of calcium from intracellular stores, and the influx of extracellular calcium.	Egtazic Acid	14-18	complement C5a receptor 1	Homo sapiens	88-100
1281157-7	1992	The purified calmodulin-independent isozyme was converted to a calmodulin-dependent isozyme by EDTA and EGTA.	Egtazic Acid	104-108	calmodulin 1	Rattus norvegicus	63-73
1336985-5	1992	In the absence of extracellular Ca2+, following chelation by EGTA, PAF was still able to induce a Ca2+ transient confirming the requirement of both intra and extracellular Ca2+ for PAF-induced platelet activation.	Egtazic Acid	61-65	PCNA clamp associated factor	Homo sapiens	67-70
1358975-12	1992	EGTA blocked the sustained component of the [Ca2+]i response to FMLP.	Egtazic Acid	0-4	formyl peptide receptor 1	Homo sapiens	64-68
1490588-6	1992	The vasorelaxant effect of ANP on AT II-induced contraction was significantly increased in Ca(2+)-free medium containing 3 mM ethylene glycol bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA-Ringer) or by pretreatment with the calcium antagonist, diltiazem (DIL).	Egtazic Acid	126-195	natriuretic peptide A	Homo sapiens	27-30
1490588-6	1992	The vasorelaxant effect of ANP on AT II-induced contraction was significantly increased in Ca(2+)-free medium containing 3 mM ethylene glycol bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA-Ringer) or by pretreatment with the calcium antagonist, diltiazem (DIL).	Egtazic Acid	126-195	angiotensinogen	Homo sapiens	34-39
1490588-6	1992	The vasorelaxant effect of ANP on AT II-induced contraction was significantly increased in Ca(2+)-free medium containing 3 mM ethylene glycol bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA-Ringer) or by pretreatment with the calcium antagonist, diltiazem (DIL).	Egtazic Acid	197-201	natriuretic peptide A	Homo sapiens	27-30
1490588-6	1992	The vasorelaxant effect of ANP on AT II-induced contraction was significantly increased in Ca(2+)-free medium containing 3 mM ethylene glycol bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA-Ringer) or by pretreatment with the calcium antagonist, diltiazem (DIL).	Egtazic Acid	197-201	angiotensinogen	Homo sapiens	34-39
1283697-2	1992	Unexpectedly, treatment of R(DAF+/CD59+) cells with Mg2(+)-EGTA-serum resulted in efficient C3 deposition, while treatment of R(DAF-/CD59-) cells did not.	Egtazic Acid	59-63	CD55 molecule (Cromer blood group)	Homo sapiens	29-32
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Egtazic Acid	76-80	interleukin 1 beta	Homo sapiens	116-134
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Egtazic Acid	76-80	phospholipase A2 group IB	Homo sapiens	254-270
1333514-9	1992	The intracellular Ca++ antagonist BAPTA and the extracellular Ca++ chelator EGTA produced significant inhibition of interleukin 1-beta-stimulated prostacyclin generation at 4 to 8 hours, suggesting either an indirect inhibitory effect of these agents on phospholipase A2 activity or that an increase in Ca++ may be a late event in the transduction scheme after interleukin 1 stimulation.	Egtazic Acid	76-80	interleukin 1 alpha	Homo sapiens	116-129
1335053-4	1992	A significant increase in [Ca++]i in response to 1 x 10(-7) M AVP was obtained with Ca(++)-free medium containing 1 x 10(-4) M ethylene glycol bis(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA) (52.3 to 98.3 nM).	Egtazic Acid	127-190	arginine vasopressin	Rattus norvegicus	62-65
1335053-4	1992	A significant increase in [Ca++]i in response to 1 x 10(-7) M AVP was obtained with Ca(++)-free medium containing 1 x 10(-4) M ethylene glycol bis(beta-aminoethyl ether)N,N"-tetraacetic acid (EGTA) (52.3 to 98.3 nM).	Egtazic Acid	192-196	arginine vasopressin	Rattus norvegicus	62-65
1335053-7	1992	Such an AVP-induced cAMP production was significantly reduced in cells exposed to Ca(++)-free medium containing 1 x 10(-4) M EGTA.	Egtazic Acid	125-129	arginine vasopressin	Rattus norvegicus	8-11
1337290-1	1992	In vitro Ca++ activates gelsolin to sever F-actin and form a gelsolin-actin (GA) complex at the+end of F-actin that is not dissociated by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) but is separated by EGTA+PIP/PIP2.	Egtazic Acid	209-213	gelsolin	Homo sapiens	24-32
1335053-8	1992	After exposure to Ca(++)-free medium containing a mixture of 1 x 10(-4) M EGTA and 1 x 10(-4) M TMB-8, the cAMP response to AVP was markedly reduced.	Egtazic Acid	74-78	arginine vasopressin	Rattus norvegicus	124-127
1337290-1	1992	In vitro Ca++ activates gelsolin to sever F-actin and form a gelsolin-actin (GA) complex at the+end of F-actin that is not dissociated by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) but is separated by EGTA+PIP/PIP2.	Egtazic Acid	209-213	gelsolin	Homo sapiens	61-69
1337290-1	1992	In vitro Ca++ activates gelsolin to sever F-actin and form a gelsolin-actin (GA) complex at the+end of F-actin that is not dissociated by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) but is separated by EGTA+PIP/PIP2.	Egtazic Acid	235-239	gelsolin	Homo sapiens	24-32
1337290-1	1992	In vitro Ca++ activates gelsolin to sever F-actin and form a gelsolin-actin (GA) complex at the+end of F-actin that is not dissociated by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) but is separated by EGTA+PIP/PIP2.	Egtazic Acid	235-239	gelsolin	Homo sapiens	61-69
1332779-6	1992	Platelet PA generation and PKC activation in response to AG-1 are inhibited by mAbs to platelet GpIIb-IIIa or by extracellular EGTA, but not by a mAb to platelet GpIb or by inhibiting platelet Na+/H+ exchange with 5-(N-ethyl-N-isopropyl)amiloride.	Egtazic Acid	127-131	NBPF member 10	Homo sapiens	57-61
1449538-2	1992	When the LMM-PLA2 and HMM-PLA2 enzymes were examined for hydrolysis against [3H]AA Escherichia coli in an ethyleneglycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA)-free buffer system, neither enzyme demonstrated activity below 10 microM free Ca2+.	Egtazic Acid	106-174	phospholipase A2 group IIA	Homo sapiens	13-17
1455400-5	1992	Purified fragment D1 of fibrinogen Osaka III also seemed to contain an apparently higher molecular weight fragment D1 gamma remnant on Laemmli gels, which was digested faster than the normal control by plasmin in the presence of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA).	Egtazic Acid	230-278	fibrinogen beta chain	Homo sapiens	24-34
1455400-5	1992	Purified fragment D1 of fibrinogen Osaka III also seemed to contain an apparently higher molecular weight fragment D1 gamma remnant on Laemmli gels, which was digested faster than the normal control by plasmin in the presence of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA).	Egtazic Acid	280-284	fibrinogen beta chain	Homo sapiens	24-34
1336123-6	1992	Insulin at a concentration of 40 to 80 microU/ml only produced a sustained increase of [Ca2+]i that was blocked by PN 200-110 or by lowering the extracellular Ca2+ concentration with EGTA.	Egtazic Acid	183-187	insulin	Homo sapiens	0-7
1449538-2	1992	When the LMM-PLA2 and HMM-PLA2 enzymes were examined for hydrolysis against [3H]AA Escherichia coli in an ethyleneglycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA)-free buffer system, neither enzyme demonstrated activity below 10 microM free Ca2+.	Egtazic Acid	106-174	phospholipase A2 group IIA	Homo sapiens	26-30
1449538-2	1992	When the LMM-PLA2 and HMM-PLA2 enzymes were examined for hydrolysis against [3H]AA Escherichia coli in an ethyleneglycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA)-free buffer system, neither enzyme demonstrated activity below 10 microM free Ca2+.	Egtazic Acid	176-180	phospholipase A2 group IIA	Homo sapiens	13-17
1449538-2	1992	When the LMM-PLA2 and HMM-PLA2 enzymes were examined for hydrolysis against [3H]AA Escherichia coli in an ethyleneglycol-bis(beta-aminoethyl ether) N,N,N",N"-tetraacetic acid (EGTA)-free buffer system, neither enzyme demonstrated activity below 10 microM free Ca2+.	Egtazic Acid	176-180	phospholipase A2 group IIA	Homo sapiens	26-30
1449538-6	1992	The presence of EGTA had a pronounced concentration-dependent effect on the activity of both the HMM- and LMM-PLA2 enzymes but only in the range of 0 to 100 microM free Ca2+.	Egtazic Acid	16-20	phospholipase A2 group IIA	Homo sapiens	110-114
1449538-7	1992	EGTA (EC50 approximately 200 microM) reduced the concentration of Ca2+ required by PLA2 to achieve 50% of maximal acylhydrolysis.	Egtazic Acid	0-4	phospholipase A2 group IIA	Homo sapiens	83-87
1449538-8	1992	In contrast, the Type I bovine pancreatic PLA2 required millimolar Ca2+ concentrations to elicit 50% of the maximal response in both EGTA-free or EGTA-containing systems, which is concordant with its extracellular role as a digestive enzyme.	Egtazic Acid	133-137	phospholipase A2 group IIA	Homo sapiens	42-46
1449538-8	1992	In contrast, the Type I bovine pancreatic PLA2 required millimolar Ca2+ concentrations to elicit 50% of the maximal response in both EGTA-free or EGTA-containing systems, which is concordant with its extracellular role as a digestive enzyme.	Egtazic Acid	146-150	phospholipase A2 group IIA	Homo sapiens	42-46
1458827-7	1992	The parasite calmodulin has properties characteristic of calmodulin isolated from other eukaryotes: an apparent molecular weight of 19 or 17 kDa in presence of EGTA or CaCl2, respectively, activation in a calcium dependent manner of bovine heart cyclic nucleotide phosphodiesterase, and its UV spectrum.	Egtazic Acid	160-164	calmodulin	Bos taurus	13-23
1458827-7	1992	The parasite calmodulin has properties characteristic of calmodulin isolated from other eukaryotes: an apparent molecular weight of 19 or 17 kDa in presence of EGTA or CaCl2, respectively, activation in a calcium dependent manner of bovine heart cyclic nucleotide phosphodiesterase, and its UV spectrum.	Egtazic Acid	160-164	calmodulin	Bos taurus	57-67
1328240-1	1992	The dephosphorylation of the mouse small heat shock protein hsp25 within an extract obtained from Ehrlich ascites tumor cells is inhibited by the calcium chelator EGTA and at concentrations of microcystin-LR which are characteristic for inhibition of calcium/calmodulin-dependent (2B type) protein phosphatases.	Egtazic Acid	163-167	heat shock protein 1	Mus musculus	60-65
1293036-2	1992	Depletion of calcium in the medium by addition of EGTA resulted in a drastic decrease in the levels of immunoreactive hCG in the medium with consequent of accumulation of hCG in the tissue.	Egtazic Acid	50-54	hypertrichosis 2 (generalised, congenital)	Homo sapiens	118-121
1293036-2	1992	Depletion of calcium in the medium by addition of EGTA resulted in a drastic decrease in the levels of immunoreactive hCG in the medium with consequent of accumulation of hCG in the tissue.	Egtazic Acid	50-54	hypertrichosis 2 (generalised, congenital)	Homo sapiens	171-174
1331121-11	1992	We have taken advantage of the different sensitivities of phospholipases A2 and C(s) to PMA, EGTA, and pertussis toxin to dissociate phospholipase A2 and C activities.	Egtazic Acid	93-97	phospholipase A2 group IB	Rattus norvegicus	133-149
1472975-14	1992	NT-induced inward currents were obtained with inclusion of 10 mM EGTA in the pipette solution and their reversal potential was around 0 mV.	Egtazic Acid	65-69	neurotensin	Gallus gallus	0-2
1330625-8	1992	On the other hand, nifedipine, Ca(2+)-free medium, EGTA and Ca(2+)-free medium/EGTA significantly reduced the bradykinin-induced contraction, indicating that part of the contractile response of basilar artery to bradykinin is dependent on extracellular Ca2+.	Egtazic Acid	51-55	kininogen 1	Canis lupus familiaris	110-120
1330625-8	1992	On the other hand, nifedipine, Ca(2+)-free medium, EGTA and Ca(2+)-free medium/EGTA significantly reduced the bradykinin-induced contraction, indicating that part of the contractile response of basilar artery to bradykinin is dependent on extracellular Ca2+.	Egtazic Acid	79-83	kininogen 1	Canis lupus familiaris	110-120
1400365-8	1992	Buffering intracellular and extracellular Ca2+ by combined treatment with BAPTA-AM (acetoxymethyl ester form of bis(aminophenoxy)ethane N,N"-tetraacetic acid) and EGTA prevented the induction of gadd153 mRNA by A23187.	Egtazic Acid	163-167	DNA damage inducible transcript 3	Homo sapiens	195-202
1326762-9	1992	Restoration of Ca2+/calmodulin to the PSD, but not of either Ca2+ or calmodulin alone, removed the effect of EGTA, indicating a strong complex formation between G(i) and Ca2+/calmodulin that decreased the ADP-ribosylation reaction.	Egtazic Acid	109-113	calmodulin 1	Homo sapiens	20-30
1400325-4	1992	Cytoskeletal association and platelet aggregation were inhibited by the peptide Arg-Gly-Asp-Ser (RGDS) (but not by Arg-Gly-Glu-Ser (RGES)), by 10E5 antibody against glycoprotein (Gp) IIb/IIIa, and by EGTA.	Egtazic Acid	200-204	ral guanine nucleotide dissociation stimulator	Homo sapiens	97-101
1417792-7	1992	PLD activity is dependent on Ca2+ influx, but is fully inhibited in cells depleted of Ca2+ with EGTA and Quin 2.	Egtazic Acid	96-100	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
1384908-4	1992	In the rat aorta, endothelin-1 (ET-1) developed a sustained tonic contraction dose-dependently in both normal Ca(2+)-containing Krebs and Ca(2+)-free Krebs containing 1 mM EGTA.	Egtazic Acid	172-176	endothelin 1	Rattus norvegicus	18-30
1384908-4	1992	In the rat aorta, endothelin-1 (ET-1) developed a sustained tonic contraction dose-dependently in both normal Ca(2+)-containing Krebs and Ca(2+)-free Krebs containing 1 mM EGTA.	Egtazic Acid	172-176	endothelin 1	Rattus norvegicus	32-36
1384908-5	1992	Calphostin C (10(-6) M), a selective protein kinase C inhibitor, antagonized the maximal tensions for cumulative addition of 10(-8) M ET-1 by 13.2% in Ca(2+)-containing medium and 25.8% in Ca(2+)-free Krebs containing 1 mM EGTA.	Egtazic Acid	223-227	endothelin 1	Rattus norvegicus	134-138
1384470-1	1992	FKBP59-HBI, a heat shock protein hsp90-binding immunophilin that was originally detected in heterooligomer forms of steroid receptors, is retained on Calmodulin (CAM)-Sepharose 4B in the presence of 2 mM Ca2+ and is eluted by EGTA, demonstrating a specific p59-CAM interaction.	Egtazic Acid	226-230	peptidyl-prolyl cis-trans isomerase FKBP4	Oryctolagus cuniculus	0-6
1384470-1	1992	FKBP59-HBI, a heat shock protein hsp90-binding immunophilin that was originally detected in heterooligomer forms of steroid receptors, is retained on Calmodulin (CAM)-Sepharose 4B in the presence of 2 mM Ca2+ and is eluted by EGTA, demonstrating a specific p59-CAM interaction.	Egtazic Acid	226-230	peptidyl-prolyl cis-trans isomerase FKBP4	Oryctolagus cuniculus	7-10
1445390-1	1992	The activity of ornithine decarboxylase (ODC) in H-35 hepatoma cells depleted of Ca2+ by washing with 2 mM EGTA increased 35-fold after incubating for 4 h in a simple salt-glucose solution containing 10 mM L-asparagine and only if Ca2+ was replenished.	Egtazic Acid	107-111	ornithine decarboxylase 1	Rattus norvegicus	16-39
1445390-1	1992	The activity of ornithine decarboxylase (ODC) in H-35 hepatoma cells depleted of Ca2+ by washing with 2 mM EGTA increased 35-fold after incubating for 4 h in a simple salt-glucose solution containing 10 mM L-asparagine and only if Ca2+ was replenished.	Egtazic Acid	107-111	ornithine decarboxylase 1	Rattus norvegicus	41-44
1333726-5	1992	When extracellular Ca2+ in the incubation medium was depleted, either by addition of EGTA or by omission of Ca2+ addition, BK still caused a significant stimulation of PGE2 formation.	Egtazic Acid	85-89	kininogen 1	Homo sapiens	123-125
1387136-9	1992	The observation that plasma membranes in cells expressing annexin V have the protein associated with them is in agreement with previous data on Ca(2+)-dependent binding of the protein to brain and heart membranes, and on existence of both EGTA- and Triton X-100-extractable and resistant fractions of annexin V in these membranes.	Egtazic Acid	239-243	annexin A5	Rattus norvegicus	58-67
1330154-14	1992	Preincubation of the cells with EGTA, verapamil, or the receptor-operated calcium channel antagonist, SK&amp;F 96365, reduced vasopressin-stimulated [3H]-PtdBuOH accumulation by approximately 30%, suggesting that influx of calcium has a significant role to play in the regulation of vasopressinstimulated PLD activity.	Egtazic Acid	32-36	arginine vasopressin	Homo sapiens	126-137
1330154-14	1992	Preincubation of the cells with EGTA, verapamil, or the receptor-operated calcium channel antagonist, SK&amp;F 96365, reduced vasopressin-stimulated [3H]-PtdBuOH accumulation by approximately 30%, suggesting that influx of calcium has a significant role to play in the regulation of vasopressinstimulated PLD activity.	Egtazic Acid	32-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	305-308
1324922-4	1992	In Ca(2+)-free EGTA buffer, thrombin induced a transient and relatively small increase in [Ca2+]i caused by Ca2+ release from internal stores.	Egtazic Acid	15-19	coagulation factor II, thrombin	Homo sapiens	28-36
1522120-5	1992	Further evidence implicating calcium in the signal transduction pathway is suggested by the finding that MAPTAM, a cell-permeant calcium chelator, in combination with the extracellular calcium chelator EGTA, can inhibit thrombin-stimulated secretion.	Egtazic Acid	202-206	coagulation factor II, thrombin	Homo sapiens	220-228
1522120-8	1992	These minimally permeabilized cells secrete vWF in response to exogenous calcium, and EGTA blocks thrombin-induced secretion.	Egtazic Acid	86-90	coagulation factor II, thrombin	Homo sapiens	98-106
1324075-3	1992	Elevation of intracellular Ca2+ resulted in activation of inward currents which were attenuated by increasing the Ca2+ buffering capacity of cells by raising the concentration of EGTA in the patch solution to 10 mM.	Egtazic Acid	179-183	carbonic anhydrase 2	Rattus norvegicus	27-30
1627556-4	1992	Chelation of Ca2+ by EGTA completely eliminated the chromogranin A-calmodulin interaction.	Egtazic Acid	21-25	chromogranin A	Bos taurus	52-66
1627556-4	1992	Chelation of Ca2+ by EGTA completely eliminated the chromogranin A-calmodulin interaction.	Egtazic Acid	21-25	calmodulin	Bos taurus	67-77
1322980-5	1992	c-fos mRNA induction by either receptor subtype is Ca2+ dependent, since chelation of Ca2+e with EGTA prevents c-fos mRNA induction by both NMDA and non-NMDA receptor agonists.	Egtazic Acid	97-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
1322980-5	1992	c-fos mRNA induction by either receptor subtype is Ca2+ dependent, since chelation of Ca2+e with EGTA prevents c-fos mRNA induction by both NMDA and non-NMDA receptor agonists.	Egtazic Acid	97-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
1322709-2	1992	PAF-mediated synthesis of prostaglandins was inhibited by the Ca2+ ion chelator (EGTA), the Ca2+ channel antagonist (nifedipine) and U66985, a structural analogue and antagonist of the biological effects of PAF in other cellular systems.	Egtazic Acid	81-85	PCNA clamp associated factor	Rattus norvegicus	0-3
1324075-3	1992	Elevation of intracellular Ca2+ resulted in activation of inward currents which were attenuated by increasing the Ca2+ buffering capacity of cells by raising the concentration of EGTA in the patch solution to 10 mM.	Egtazic Acid	179-183	carbonic anhydrase 2	Rattus norvegicus	114-117
1353854-7	1992	In the absence of Ca2+, an increase of NGF mRNA was still observed but in the presence of 1 mM ethylglycol-bis-(beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA), NGF mRNA production abolished.	Egtazic Acid	158-162	nerve growth factor	Homo sapiens	39-42
1611079-8	1992	EGTA chelation of extracellular Ca2+ completely inhibited vWF-mediated [Ca2+]i and aggregation responses to shear stress.	Egtazic Acid	0-4	von Willebrand factor	Homo sapiens	58-61
1509490-5	1992	Added phosphate ion at 5 mM and removal of membrane-bound Ca2+ by treatment with 10 mM EGTA make more binding sites of the same affinity available to both peptides, which are shown to bind in a competitive fashion to the same site.	Egtazic Acid	87-91	carbonic anhydrase 2	Mus musculus	58-61
1512072-6	1992	EGTA inhibited sIL-2R release in the same manner when used alone, and reversed the CsA- and prednisolone-induced enhancement of sIL-2R release by rIL-2 induced lymphoblasts, when used in combination with CsA or prednisolone.	Egtazic Acid	0-4	interleukin 2	Rattus norvegicus	146-151
1303144-7	1992	This speculation is further supported by the fact that the elevated [Ca2+]i induced by thrombin immediately decreased to the base line value when 3 mM EGTA was applied.	Egtazic Acid	151-155	prothrombin	Oryctolagus cuniculus	87-95
1618787-7	1992	cPKC alpha and nPKC zeta were predominantly localized in the cytosol when subcellular fractionation was carried out in the presence of [ethylenebis(oxyethylenenitrilo)]tetraacetic acid.	Egtazic Acid	136-184	protein kinase C, zeta	Rattus norvegicus	15-24
1397009-1	1992	In rat aorta, endothelin-1 (ET-1) induced a slowly developing and sustained contraction in Ca(2+)-containing normal Krebs, nominally Ca(2+)-free Krebs, and Ca(2+)-free Krebs containing EGTA with a decreasing level of contraction.	Egtazic Acid	185-189	endothelin 1	Rattus norvegicus	14-26
1397009-1	1992	In rat aorta, endothelin-1 (ET-1) induced a slowly developing and sustained contraction in Ca(2+)-containing normal Krebs, nominally Ca(2+)-free Krebs, and Ca(2+)-free Krebs containing EGTA with a decreasing level of contraction.	Egtazic Acid	185-189	endothelin 1	Rattus norvegicus	28-32
1397009-2	1992	When ET-1-precontracted tissues were washed with Ca(2+)-free Krebs +50 microM EGTA, the tissues spontaneously and slowly relaxed.	Egtazic Acid	78-82	endothelin 1	Rattus norvegicus	5-9
1581303-6	1992	Diisopropyl fluorophosphate, EDTA, and EGTA inhibited oviductin irreversibly; soybean trypsin inhibitor, aprotinin, guanidine hydrochloride (Ki = 7.5 mM), and p-amino-benzamidine (Ki = 4.1 microM) also inhibited, but iodoacetamide, E-64, pepstatin, or 1,10-phenanthroline did not.	Egtazic Acid	39-43	ovochymase 2 S homeolog	Xenopus laevis	54-63
1323562-4	1992	To obtain further information on the nucleotide binding properties of gelsolin, binding studies were done in the presence of EGTA with GTP, ADP, and GDP by equilibrium dialysis.	Egtazic Acid	125-129	gelsolin	Homo sapiens	70-78
1513338-5	1992	The pronounced effect of regucalcin on the proteinase activity was also seen in the presence of 1.0 mM EGTA with or without Ca2+ (5.0 microM).	Egtazic Acid	103-107	regucalcin	Rattus norvegicus	25-35
1590389-6	1992	Monitor peptide stimulated CCK release in a dose-dependent manner at concentrations from 3 x 10(-12) to 3 x 10(-8) M. The requirement for extracellular calcium in secretagogue-stimulated release of CCK was investigated using ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA), a calcium chelator, and MnCl2.	Egtazic Acid	225-294	cholecystokinin	Rattus norvegicus	198-201
1590389-6	1992	Monitor peptide stimulated CCK release in a dose-dependent manner at concentrations from 3 x 10(-12) to 3 x 10(-8) M. The requirement for extracellular calcium in secretagogue-stimulated release of CCK was investigated using ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA), a calcium chelator, and MnCl2.	Egtazic Acid	296-300	cholecystokinin	Rattus norvegicus	198-201
1590389-7	1992	A calcium-free environment supplemented with 2 mM EGTA completely inhibited CCK secretion in response to stimulatory doses of monitor peptide.	Egtazic Acid	50-54	cholecystokinin	Rattus norvegicus	76-79
1315244-5	1992	NaF-provoked gonadotrope desensitization to GnRH also occurred in the presence of 3 mM EGTA and in cells which had been depleted of protein kinase C. Desensitization to GnRH did not occur in response to pretreatment with (Bu)2cAMP (8 h, 1 mM).	Egtazic Acid	87-91	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1380386-12	1992	Incubation in "nominally" Ca(2+)-free medium attenuated the vasoconstrictor response to endothelin-1 but not to sarafotoxin S6b, which was inhibited after incubation in Ca(2+)-free medium to which EGTA (10(-4) M) had been added.	Egtazic Acid	197-201	endothelin-1	Capra hircus	88-100
1315244-5	1992	NaF-provoked gonadotrope desensitization to GnRH also occurred in the presence of 3 mM EGTA and in cells which had been depleted of protein kinase C. Desensitization to GnRH did not occur in response to pretreatment with (Bu)2cAMP (8 h, 1 mM).	Egtazic Acid	87-91	gonadotropin releasing hormone 1	Homo sapiens	44-48
1516274-14	1992	ET-1 responses were inhibited in Ca(2+)-free Krebs" solution (plus 1 mmol/L EGTA).	Egtazic Acid	76-80	endothelin 1	Rattus norvegicus	0-4
1348694-5	1992	Immunofluorescence studies showed that cross-linked annexin I and involucrin form an envelope-like structure in SqCC/Y1 cells during differentiation that cannot be extracted by EGTA and Triton X-100.	Egtazic Acid	177-181	involucrin	Homo sapiens	66-76
1314112-8	1992	Alpha-Thrombin-stimulated PEt formation was abolished (greater than 90% inhibition) with chelation of intracellular calcium (Ca2+i) by pretreatment with BAPTA-AM (25 mumol/L, 30 minutes) but only mildly attenuated (30% inhibition) by removal of extracellular calcium (Ca2+E) with EGTA (5 mmol/L).	Egtazic Acid	280-284	coagulation factor II, thrombin	Homo sapiens	6-14
1560018-4	1992	The myelin-associated PLP fatty acylesterase has no apparent requirements for divalent cations (Ca2+, Mg2+, Mn2+), and chelators such as EDTA, [ethylenebis(oxyethylenenitrilo)] tetraacetic acid, and 1,10-phenantroline have little or no effect on enzyme activity.	Egtazic Acid	144-193	proteolipid protein 1	Bos taurus	22-25
1569136-4	1992	Following ischemia, CA1 pyramidal neurons showed increased spontaneous firing that was highly voltage dependent and was blocked by intracellular injection of the Ca2+ chelator, EGTA.	Egtazic Acid	177-181	carbonic anhydrase 1	Homo sapiens	20-23
1569136-4	1992	Following ischemia, CA1 pyramidal neurons showed increased spontaneous firing that was highly voltage dependent and was blocked by intracellular injection of the Ca2+ chelator, EGTA.	Egtazic Acid	177-181	carbonic anhydrase 2	Homo sapiens	162-165
1333414-0	1992	The amino-terminal fragment of gelsolin is cross-linked to Cys-374 of actin in the EGTA-resistant actin-gelsolin complex.	Egtazic Acid	83-87	GSN	Sus scrofa	31-39
1333414-0	1992	The amino-terminal fragment of gelsolin is cross-linked to Cys-374 of actin in the EGTA-resistant actin-gelsolin complex.	Egtazic Acid	83-87	GSN	Sus scrofa	104-112
1333414-1	1992	It has been shown that the EGTA-resistant actin, one of the two actin molecules associated to gelsolin, can be predominantly cross-linked to gelsolin by benzophenone-4-maleimide (BPM), a photoaffinity-labeling reagent, which was conjugated to Cys-374 of actin prior to cross-linking (Doi, Y., Banba, M. and Vertut-Doi, A.	Egtazic Acid	27-31	GSN	Sus scrofa	94-102
1333414-1	1992	It has been shown that the EGTA-resistant actin, one of the two actin molecules associated to gelsolin, can be predominantly cross-linked to gelsolin by benzophenone-4-maleimide (BPM), a photoaffinity-labeling reagent, which was conjugated to Cys-374 of actin prior to cross-linking (Doi, Y., Banba, M. and Vertut-Doi, A.	Egtazic Acid	27-31	GSN	Sus scrofa	141-149
1333414-4	1992	The amino-terminal sequence of the 58-kDa complex was identical to that of gelsolin, confirming that the amino-terminal segment (residues 1-133) of pig plasma gelsolin lies closely to Cys-374 of actin in the EGTA-resistant complex.	Egtazic Acid	208-212	GSN	Sus scrofa	159-167
1515919-6	1992	Omission of Ca2+ from and addition of EGTA to the aCSF decreased the osmotically stimulated, but not the basal AVP release.	Egtazic Acid	38-42	arginine vasopressin	Rattus norvegicus	111-114
1612637-5	1992	Addition of tumor cells to LAK cells, generated in the presence of IL-2 alone or along with CP/FK-565 caused an instant rise in intracellular free calcium which was significantly decreased when an increase in intracellular free calcium was observed in calcium-free, EGTA-containing buffer.	Egtazic Acid	266-270	interleukin 2	Homo sapiens	67-71
1535196-2	1992	The binding of vasopressin was enhanced by Mg2+ and Co2+ and markedly decreased by EGTA.	Egtazic Acid	83-87	arginine vasopressin	Rattus norvegicus	15-26
1312103-3	1992	The cytosolic free Ca2+ concentration increase was inhibited by the PAF receptor antagonist L-659,989 (10 microM) and by EGTA (2 mM), indicating receptor-dependent Ca2+ influx.	Egtazic Acid	121-125	carbonic anhydrase 2	Homo sapiens	19-22
1312103-3	1992	The cytosolic free Ca2+ concentration increase was inhibited by the PAF receptor antagonist L-659,989 (10 microM) and by EGTA (2 mM), indicating receptor-dependent Ca2+ influx.	Egtazic Acid	121-125	carbonic anhydrase 2	Homo sapiens	164-167
1312103-5	1992	Consistent with these results, PAF (100 nM) stimulated release of arachidonic acid and thromboxane B2 only in LPS-treated cells, and this could be inhibited by L-659,989 (10 microM) and EGTA (2 mM).	Egtazic Acid	186-190	PCNA clamp associated factor	Homo sapiens	31-34
1381750-12	1992	Intra-arterial infusion of EGTA (2 mM) abolished the forskolin- and peptone-induced CCK secretion while luminal EGTA (2 mM) had no inhibitory effect.	Egtazic Acid	27-31	cholecystokinin	Rattus norvegicus	84-87
1304352-5	1992	In the presence of EGTA, yeast calmodulin is more susceptible to proteolysis and is preferentially cleaved at Lys-106.	Egtazic Acid	19-23	calmodulin	Saccharomyces cerevisiae S288C	31-41
1304352-8	1992	Furthermore, whereas wild-type calmodulin is cut at Lys-106 only in the presence of EGTA, this cleavage site is accessible in the mutants in the presence of Ca2+ as well.	Egtazic Acid	84-88	calmodulin	Saccharomyces cerevisiae S288C	31-41
1621245-5	1992	EGTA eluates from the affinity columns contained scinderin as demonstrated by mono and two-dimensional polyacrylamide gel electrophoresis and immunoblotting with scinderin antibodies.	Egtazic Acid	0-4	scinderin	Homo sapiens	49-58
1544231-6	1992	Furthermore, apoptosis could be induced in HL-60 cells under conditions of vastly reduced [Ca2+]i achieved by loading these cells with fura-2 in the presence of EGTA.	Egtazic Acid	161-165	carbonic anhydrase 2	Homo sapiens	91-94
1379205-5	1992	The contractions evoked by ET-1 were markedly reduced in Ca-free medium containing 1 mM EGTA and by the Ca channel antagonist, nifedipine (1 microM), but increased by the Ca channel agonist, BAY K 8644 (10 nM).	Egtazic Acid	88-92	endothelin 1	Bos taurus	27-31
1616824-7	1992	Moreover, the level of the PKC activity detected in the presence of EGTA was comparable to the level of kinase activity, measured in the presence of PS alone or associated with DAG or PMA.	Egtazic Acid	68-72	protein kinase C, gamma	Rattus norvegicus	27-30
1621245-5	1992	EGTA eluates from the affinity columns contained scinderin as demonstrated by mono and two-dimensional polyacrylamide gel electrophoresis and immunoblotting with scinderin antibodies.	Egtazic Acid	0-4	scinderin	Homo sapiens	162-171
1531187-2	1992	Bovine heart 67-kd protein (p67) was coisolated with calpactin I complex by cycles of Ca(2+)-dependent precipitation followed by solubilization with EGTA-containing buffer.	Egtazic Acid	149-153	guanylate binding protein 2	Rattus norvegicus	28-31
1351912-8	1992	When gamma-irradiated thymocytes were incubated with the Ca2+ chelator EGTA, DNA fragmentation was reduced significantly.	Egtazic Acid	71-75	carbonic anhydrase 2	Rattus norvegicus	57-60
1740241-9	1992	Chelation of extracellular ionized calcium by EGTA or of intracellular ionized calcium by Quin 2/AM resulted in a marked decrease of c-fos expression.	Egtazic Acid	46-50	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-138
1732416-6	1992	Fragmentin and cytolysin activity were completely inhibited by EGTA, indicating the process was Ca2+ dependent.	Egtazic Acid	63-67	perforin 1 (pore forming protein)	Mus musculus	15-24
1581032-7	1992	When the levels of extracellular Ca2+ were adjusted with 1 mM EGTA to maximum values ranging from 7.1 to 320 microM, cells displayed a rounded morphology in the presence of exogenous SPARC.	Egtazic Acid	62-66	secreted protein acidic and cysteine rich	Bos taurus	183-188
1310053-0	1992	Characterization of EGTA-washed synaptosomal membrane with emphasis on its calmodulin-binding proteins.	Egtazic Acid	20-24	calmodulin 1	Homo sapiens	75-85
1310053-2	1992	Endogenous calmodulin (CaM) in the EGTA-washed cerebral-cortical synaptosomal membrane (SM) preparation was estimated below 3 micrograms/ml protein by the semiquantitative immunoblot analysis (Natsukari, N., Ohta, H. and Fujita, M. (1989) J. Immunol.	Egtazic Acid	35-39	calmodulin 1	Homo sapiens	11-21
1310053-2	1992	Endogenous calmodulin (CaM) in the EGTA-washed cerebral-cortical synaptosomal membrane (SM) preparation was estimated below 3 micrograms/ml protein by the semiquantitative immunoblot analysis (Natsukari, N., Ohta, H. and Fujita, M. (1989) J. Immunol.	Egtazic Acid	35-39	calmodulin 1	Homo sapiens	23-26
1310053-4	1992	Membrane-bound CaM was immunoelectron-microscopically demonstrated in EGTA-washed, non-treated (control), and Ca(2+)-treated cerebral-cortical synaptosomal membranes (SM) as well as for the SM enriched with added CaM.	Egtazic Acid	70-74	calmodulin 1	Homo sapiens	15-18
1310053-14	1992	The present findings suggested that the EGTA-washed SM preparation made a useful system for studying the role of CaM in the brain SM.	Egtazic Acid	40-44	calmodulin 1	Homo sapiens	113-116
1636501-4	1992	The effect of PLA2 was prevented by incubation with EGTA (2 x 10(-3)) or bovine serum albumin (BSA; 1:1).	Egtazic Acid	52-56	phospholipase A2 group IB	Rattus norvegicus	14-18
1730760-4	1992	The appearance of dopamine-beta-hydroxylase on the oocyte surface was strongly Ca(2+)-dependent and was stimulated by coinjection of the chromaffin granule membranes with InsP3 or Ca2+/EGTA buffer (18 microM free Ca2+) or by incubation of the injected oocytes in medium containing the Ca2+ ionophore ionomycin.	Egtazic Acid	185-189	dopamine beta-hydroxylase	Bos taurus	18-43
1752461-4	1991	NaF stimulated adenylate cyclase activity was inhibited by 50% at 2.5 mmol/l EGTA.	Egtazic Acid	77-81	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
1661732-5	1991	Coverslips coated with gelsolin, a multi-domain, calcium-dependent capping and severing protein, bound rhodamine-phalloidin-saturated filaments along their length in the presence of EGTA.	Egtazic Acid	182-186	Gelsolin	Drosophila melanogaster	23-31
1744509-5	1991	Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the GPIIb-IIIa complex nor platelet fibrinogen was expressed on the surface of thrombin-activated platelets.	Egtazic Acid	192-196	fibrinogen beta chain	Homo sapiens	29-39
1744509-5	1991	Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the GPIIb-IIIa complex nor platelet fibrinogen was expressed on the surface of thrombin-activated platelets.	Egtazic Acid	192-196	fibrinogen beta chain	Homo sapiens	259-269
1744509-5	1991	Studies correlating platelet fibrinogen surface expression with the presence of the glycoprotein IIb-IIIa (GPIIb-IIIa) complex showed that in the presence of ethylene glycol tetraacetic acid (EGTA) at 37 degrees C, neither the GPIIb-IIIa complex nor platelet fibrinogen was expressed on the surface of thrombin-activated platelets.	Egtazic Acid	192-196	coagulation factor II, thrombin	Homo sapiens	302-310
1744509-6	1991	Similar experiments performed in the presence of EGTA and calcium showed proportional expression of the GPIIb-IIIa complex and platelet fibrinogen.	Egtazic Acid	49-53	fibrinogen beta chain	Homo sapiens	136-146
21431660-4	1992	The procedure has been developed to allow separation of calmodulin from other calcium-binding proteins, exploiting differences in affinity for calcium and in hydrophobicity, and hence elution time in EGTA (3,4).	Egtazic Acid	200-204	calmodulin 1	Homo sapiens	56-66
1630540-11	1992	In contrast, inactivation of the classical pathway (NHS-EGTA) decreased the early but not the late generation of Mac-1-mobilizating capacity.	Egtazic Acid	56-60	NHS actin remodeling regulator	Homo sapiens	52-55
1630540-11	1992	In contrast, inactivation of the classical pathway (NHS-EGTA) decreased the early but not the late generation of Mac-1-mobilizating capacity.	Egtazic Acid	56-60	integrin subunit alpha M	Homo sapiens	113-118
1744114-3	1991	EGTA inhibited the activation of phospholipase D (PLD) by 55% (n = 4).	Egtazic Acid	0-4	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-48
1744114-3	1991	EGTA inhibited the activation of phospholipase D (PLD) by 55% (n = 4).	Egtazic Acid	0-4	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	50-53
1822240-15	1991	The Man9-alpha-mannosidase required low levels of Ca2+, which could be removed by EGTA.	Egtazic Acid	82-86	alpha-mannosidase	Saccharomyces cerevisiae S288C	9-26
1833215-4	1991	Second, treatment of HUVE cell particulate fractions with EGTA and hydrophobic affinity chromatography in combination with conventional techniques provided extracts rich in p69 and purified p69.	Egtazic Acid	58-62	islet cell autoantigen 1	Homo sapiens	173-176
1833215-4	1991	Second, treatment of HUVE cell particulate fractions with EGTA and hydrophobic affinity chromatography in combination with conventional techniques provided extracts rich in p69 and purified p69.	Egtazic Acid	58-62	islet cell autoantigen 1	Homo sapiens	190-193
1655771-7	1991	Induction of IL-2/CAT activity by all stimuli in both cell lines was blocked by the presence of EGTA in the culture medium.	Egtazic Acid	96-100	interleukin 2	Homo sapiens	13-17
1659593-8	1991	Furthermore, when similar experiments were conducted in the presence of an extracellular calcium chelator, ethylene glycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid, there was partial suppression in both the cellular fluorescence and O2- generation to PAF; this suggests that full expression of EOS generation of O2- by PAF requires both intracellular mobilization and a transmembrane influx of Ca++.	Egtazic Acid	107-176	PCNA clamp associated factor	Homo sapiens	264-267
1659593-8	1991	Furthermore, when similar experiments were conducted in the presence of an extracellular calcium chelator, ethylene glycol-bis-(beta-aminoethylether)-N,N,N",N"-tetraacetic acid, there was partial suppression in both the cellular fluorescence and O2- generation to PAF; this suggests that full expression of EOS generation of O2- by PAF requires both intracellular mobilization and a transmembrane influx of Ca++.	Egtazic Acid	107-176	PCNA clamp associated factor	Homo sapiens	332-335
1658154-8	1991	In HDMEC incubated with 100 nM ET-1, inhibition of PGE2 release was unaffected by the dihydropyridine Ca++ channel antagonist nifedipine or the extracellular Ca++ chelator EGTA, whereas the intracellular Ca++ chelator TMB-8 partially blocked the action of ET-1.	Egtazic Acid	172-176	endothelin 1	Homo sapiens	31-35
1930148-6	1991	Chelation of the extracellular Ca2+ with EGTA prior to the addition of HDL3 did not prevent the HDL3-induced rise in [Ca2+]i, suggesting that the mobilized Ca2+ was derived mainly from intracellular stores.	Egtazic Acid	41-45	carbonic anhydrase 2	Homo sapiens	31-34
1655888-8	1991	Although transmembrane signaling by FMLP and Con A requires an increase in intracellular calcium for some polymorphonuclear leukocyte (PMN) functional responses, calcium depletion of PMN by incubation with 100 microM Quin 2 A/M and 5 mM EGTA did not prevent the stimulation of PIP kinase by FMLP or Con A.	Egtazic Acid	237-241	formyl peptide receptor 1	Homo sapiens	36-40
1917990-8	1991	On an alkaline/urea gel, calgizzarin migrated faster in the presence of EGTA than in the presence of CaCl2, thereby indicating a Ca(2+)-dependent conformational change in this protein.	Egtazic Acid	72-76	protein S100-A11	Oryctolagus cuniculus	25-36
1837758-5	1991	At high Ca2+ concentrations (greater than 1 mM) sperm calpactin II binds to actin filament and it is resolubilized by EGTA.	Egtazic Acid	118-122	annexin A1	Homo sapiens	54-66
1660513-4	1991	The eluted protein from a calmodulin-coupled Sepharose 4B column with EGTA was analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis which revealed a major protein band of Mr 50,000.	Egtazic Acid	70-74	calmodulin 1	Rattus norvegicus	26-36
1804554-2	1991	The beta-glucuronidase release induced by CuPh was inhibited by ethylene glycol bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	64-132	glucuronidase beta	Homo sapiens	4-22
1653231-4	1991	These channel activities were markedly reduced by exposure of membranes to EGTA at 37 degrees C. This reduction was specifically related to the dissociation of the GPIIb-IIIa complex since preincubation of the membranes with a monoclonal antibody to the GPIIb-IIIa complex (AP-2) could protect the channel activities from the effect of EGTA.	Egtazic Acid	75-79	transcription factor AP-2 alpha	Homo sapiens	274-278
1653231-6	1991	Furthermore, when platelets were stimulated by thrombin in the presence of EGTA, AP2, or the synthetic peptide RGDS, to prevent fibrinogen binding to the GPIIb-IIIa complex, open probabilities of the channel currents in these membrane vesicles were also decreased.	Egtazic Acid	75-79	coagulation factor II, thrombin	Homo sapiens	47-55
1653231-6	1991	Furthermore, when platelets were stimulated by thrombin in the presence of EGTA, AP2, or the synthetic peptide RGDS, to prevent fibrinogen binding to the GPIIb-IIIa complex, open probabilities of the channel currents in these membrane vesicles were also decreased.	Egtazic Acid	75-79	fibrinogen beta chain	Homo sapiens	128-138
1686201-15	1991	This effect may be due to Gd3+ entry into the nerve endings since it is not reversed upon removal of extracellular Gd3+ with chelators (1 mM EGTA or EDTA).	Egtazic Acid	141-145	GRDX	Homo sapiens	26-29
1834809-4	1991	Levels of phosphorylated GAP-43 in the intact IGCs are also modulated by calcium-stimulated dephosphorylation that could be inhibited by EGTA but not okadaic acid and that therefore resembled the calcineurin-stimulated dephosphorylation reported in vitro.	Egtazic Acid	137-141	growth associated protein 43	Homo sapiens	25-31
1716985-1	1991	Determinations of aqueous space volumes, swelling and Mg2+ release experiments demonstrate that EGTA plus uncoupler causes the permeability transition in Ca(2+)-loaded mitochondria.	Egtazic Acid	96-100	mucin 7, secreted	Homo sapiens	54-57
1804554-2	1991	The beta-glucuronidase release induced by CuPh was inhibited by ethylene glycol bis(beta-aminoethylether)-N,N,N",N"-tetraacetic acid (EGTA).	Egtazic Acid	134-138	glucuronidase beta	Homo sapiens	4-22
1892881-3	1991	This enhancement of the cytosolic 15-lipoxygenase activity, which was reversible by EGTA, was inhibited by phosphatidyl serine and phosphatidyl choline.	Egtazic Acid	84-88	arachidonate 15-lipoxygenase	Homo sapiens	34-49
1714830-4	1991	In the absence of PTH, renin release was inversely correlated with ionized calcium (Ca2+) concentration, with the highest release of renin noted with 1 mM EGTA and no added calcium.	Egtazic Acid	155-159	renin	Rattus norvegicus	23-28
1714830-4	1991	In the absence of PTH, renin release was inversely correlated with ionized calcium (Ca2+) concentration, with the highest release of renin noted with 1 mM EGTA and no added calcium.	Egtazic Acid	155-159	renin	Rattus norvegicus	133-138
1874183-5	1991	When added together at maximally effective concentrations, PTH and thrombin produced additive effects on Cai2+ in the presence and absence of EGTA.	Egtazic Acid	142-146	parathyroid hormone	Rattus norvegicus	59-62
1874183-5	1991	When added together at maximally effective concentrations, PTH and thrombin produced additive effects on Cai2+ in the presence and absence of EGTA.	Egtazic Acid	142-146	coagulation factor II	Rattus norvegicus	67-75
1663112-2	1991	Both Ca2+/calmodulin-dependent protein kinase activity and its substrate were present in a cytoskeletal fraction, obtained as a pellet after washing of the membrane fraction with 2 mM EGTA, 0.6 M NaCl, and 1% Triton X-100.	Egtazic Acid	184-188	calmodulin 1	Rattus norvegicus	10-20
1918577-6	1991	Decreasing extracellular calcium ion (Ca2+o) to less than 0.1 mumol/L with 2 mmol/L EGTA relaxed MA, but not LA.	Egtazic Acid	84-88	carbonic anhydrase 2	Canis lupus familiaris	38-41
1686932-3	1991	EGTA and LaCl3 decreased ANF-s-GC and calmodulin reversed this inhibition.	Egtazic Acid	0-4	natriuretic peptide A	Homo sapiens	25-28
1911840-1	1991	A proteinase specific for calmodulin has been identified in a crude rat kidney Triton-extracted or sonicated mitochondrial fraction and solubilized by EGTA extraction of these membranes.	Egtazic Acid	151-155	calmodulin 1	Rattus norvegicus	26-36
1911840-3	1991	This enzyme is active in the presence of EGTA, but not in the presence of calcium, and cleaves calmodulin into three major peptide fragments with Mr 6000, 9000 and 10,000.	Egtazic Acid	41-45	calmodulin 1	Rattus norvegicus	95-105
1911840-4	1991	N-methylated and non-methylated calmodulins were both cleaved by calmodulin proteinase and while troponin was a poor substrate, it was cleaved in the presence of either calcium or EGTA.	Egtazic Acid	180-184	calmodulin 1	Rattus norvegicus	32-42
1944612-8	1991	Treatment of the vascular tissues with EGTA (5 mM) or incubation in Ca(2+)-free media abolished the SCN(-)-induced contractile responses.	Egtazic Acid	39-43	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	100-103
1650153-6	1991	Inhibition of protein synthesis by cycloheximide blocked the PAF-enhanced NK cell activity after preincubation for 18 h. Extracellular Ca2+ was also needed for the action of PAF as suggested by the effects of Ca2+ chelation with ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and inhibition of Ca2+ entry into the cells with verapamil and diltiazem, all of which abrogated the action of PAF.	Egtazic Acid	229-293	PCNA clamp associated factor	Rattus norvegicus	61-64
1650153-6	1991	Inhibition of protein synthesis by cycloheximide blocked the PAF-enhanced NK cell activity after preincubation for 18 h. Extracellular Ca2+ was also needed for the action of PAF as suggested by the effects of Ca2+ chelation with ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and inhibition of Ca2+ entry into the cells with verapamil and diltiazem, all of which abrogated the action of PAF.	Egtazic Acid	229-293	PCNA clamp associated factor	Rattus norvegicus	174-177
1650153-6	1991	Inhibition of protein synthesis by cycloheximide blocked the PAF-enhanced NK cell activity after preincubation for 18 h. Extracellular Ca2+ was also needed for the action of PAF as suggested by the effects of Ca2+ chelation with ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and inhibition of Ca2+ entry into the cells with verapamil and diltiazem, all of which abrogated the action of PAF.	Egtazic Acid	229-293	PCNA clamp associated factor	Rattus norvegicus	174-177
1650153-6	1991	Inhibition of protein synthesis by cycloheximide blocked the PAF-enhanced NK cell activity after preincubation for 18 h. Extracellular Ca2+ was also needed for the action of PAF as suggested by the effects of Ca2+ chelation with ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and inhibition of Ca2+ entry into the cells with verapamil and diltiazem, all of which abrogated the action of PAF.	Egtazic Acid	295-299	PCNA clamp associated factor	Rattus norvegicus	61-64
1650153-6	1991	Inhibition of protein synthesis by cycloheximide blocked the PAF-enhanced NK cell activity after preincubation for 18 h. Extracellular Ca2+ was also needed for the action of PAF as suggested by the effects of Ca2+ chelation with ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and inhibition of Ca2+ entry into the cells with verapamil and diltiazem, all of which abrogated the action of PAF.	Egtazic Acid	295-299	PCNA clamp associated factor	Rattus norvegicus	174-177
1650153-6	1991	Inhibition of protein synthesis by cycloheximide blocked the PAF-enhanced NK cell activity after preincubation for 18 h. Extracellular Ca2+ was also needed for the action of PAF as suggested by the effects of Ca2+ chelation with ethyleneglycol-bis-(beta-aminoethyl ether)-N,N"-tetraacetic acid (EGTA) and inhibition of Ca2+ entry into the cells with verapamil and diltiazem, all of which abrogated the action of PAF.	Egtazic Acid	295-299	PCNA clamp associated factor	Rattus norvegicus	174-177
1650299-3	1991	In contrast, after the treatment with caffeine plus ryanodine (30 microM), which inactivates the caffeine-sensitive channel, and with 1 mM Ca2+ chelator (EGTA) instead of Ca2+ in the incubation medium to block the CA2+ entry from outside, angiotensin II (10 nM) induced the Ca2+i elevation (287 +/- 26%) in previously caffeine-nonresponsive cells, although caffeine-responsive cells retained quiescence (112 +/- 2%).	Egtazic Acid	154-158	angiotensinogen	Rattus norvegicus	239-253
1831222-10	1991	p68 was identified as a calcium-binding protein by its ability to be solubilized from B lymphocyte membranes by EGTA, a calcium-chelating agent, to bind specifically on phenothiazine-Sepharose in a calcium-dependent interaction, and to be recognized by specific antibodies directed against human p68, a calcium-binding protein of the annexin VI family.	Egtazic Acid	112-116	annexin A6	Homo sapiens	0-3
1831222-10	1991	p68 was identified as a calcium-binding protein by its ability to be solubilized from B lymphocyte membranes by EGTA, a calcium-chelating agent, to bind specifically on phenothiazine-Sepharose in a calcium-dependent interaction, and to be recognized by specific antibodies directed against human p68, a calcium-binding protein of the annexin VI family.	Egtazic Acid	112-116	annexin A6	Homo sapiens	296-299
1883854-7	1991	Cytosolic protein phosphorylation in the presence of EGTA resulted in phosphorylation of proteins of 68 kDa and 19 kDa which was increased by prolactin.	Egtazic Acid	53-57	prolactin	Homo sapiens	142-151
1864358-2	1991	When extracellular Ca2+ was chelated by EGTA, 50 microM sphingosine failed to increase [Ca2+]i, but 100 or 200 microM sphingosine induced a slight and transient increase in [Ca2+]i.	Egtazic Acid	40-44	carbonic anhydrase 2	Rattus norvegicus	19-22
1830305-5	1991	Formation of the thapsigargin-enzyme complex is also favored by Ca2+ chelation with EGTA, with consequent inhibition of the enzyme reactivity to Pi (i.e. reverse of the ATPase hydrolytic reaction).	Egtazic Acid	84-88	dynein axonemal heavy chain 8	Homo sapiens	169-175
1905229-2	1991	Concentrations of TRH greater than 10 nM caused a rapid but transient increase in [Ca2+]i, arising mainly from intracellular calcium stores, since it was unaffected by lowering extracellular calcium with EGTA or blocking calcium channels with Co2+.	Egtazic Acid	204-208	thyrotropin releasing hormone	Bos taurus	18-21
1844113-4	1991	When the EGTA was removed and a total concentration of calcium (100 uM) was kept constant in the incubation media, calmodulin stimulated the ATPase four fold over the non stimulated conditions in both studied groups.	Egtazic Acid	9-13	calmodulin 1	Homo sapiens	115-125
1646000-0	1991	Cysteine-374 of actin resides at the gelsolin contact site in the EGTA-resistant actin-gelsolin complex.	Egtazic Acid	66-70	GSN	Sus scrofa	37-45
1648924-4	1991	Four-hour preincubation in calcium-free medium or in complete medium containing 5 mM [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) protected against the cytotoxicity of VP-16.	Egtazic Acid	86-134	host cell factor C1	Homo sapiens	180-185
1648924-4	1991	Four-hour preincubation in calcium-free medium or in complete medium containing 5 mM [ethylenebis(oxyethylenenitrilo)]tetraacetic acid (EGTA) protected against the cytotoxicity of VP-16.	Egtazic Acid	136-140	host cell factor C1	Homo sapiens	180-185
1646000-0	1991	Cysteine-374 of actin resides at the gelsolin contact site in the EGTA-resistant actin-gelsolin complex.	Egtazic Acid	66-70	GSN	Sus scrofa	87-95
1646000-7	1991	The results show that Cys-374 at the C-terminal segment of actin in the EGTA-resistant AG complex is 9-10 A apart from gelsolin.	Egtazic Acid	72-76	GSN	Sus scrofa	119-127
1747420-2	1991	The ATP/ADP-antiporter inhibitor carboxyatractylate slowed down the respiration rate, increased delta psi and decreased the ionic conductivity of the inner mitochondrial membrane as measured by the rate of the delta psi decline after addition of cyanide (in the presence of oligomycin and EGTA).	Egtazic Acid	289-293	ATPase phospholipid transporting 8A2	Homo sapiens	4-22
1893172-5	1991	In the presence of 2mM EGTA, PAF raised Ca2+ to a lesser extent.	Egtazic Acid	23-27	patchy fur	Mus musculus	29-32
1715762-1	1991	T cell proliferation, in the presence of monocytes, triggered either by an anti-CD3 monoclonal antibody (mAb) or by a mitogenic pair of anti-CD2 mAbs was inhibited either by the calcium chelator EGTA or the calcium channel blocker nifedipin.	Egtazic Acid	195-199	CD2 molecule	Homo sapiens	141-144
1715762-4	1991	On the other hand, IL-1 production by LPS-stimulated monocytes was strongly decreased both by EGTA and nifedipin.	Egtazic Acid	94-98	interleukin 1 alpha	Homo sapiens	19-23
1715762-5	1991	Northern blot analysis showed that this inhibition paralleled a decrease of IL-1 alpha and beta messenger RNA (mRNA) expression only in the presence of EGTA but not in the presence of nifedipin.	Egtazic Acid	152-156	interleukin 1 alpha	Homo sapiens	76-86
1653849-15	1991	If a high concentration (18 mM) of the calcium chelator EGTA was included in the pipette solution, caffeine and 3Me-His2-TRH had markedly lower effects on the GABAA response than those observed at pCa 7, suggesting that the effect of both substances was mediated by an increase in [Ca2+]i.	Egtazic Acid	56-60	thyrotropin releasing hormone	Homo sapiens	121-124
1902789-4	1991	Consequently, the complexing of extracellular calcium by EGTA stops phospholipase A2 activity immediately, whereas added arachidonate can be still adequately metabolized by intracellular Ca2+ release triggered by fMLF or PAF.	Egtazic Acid	57-61	phospholipase A2 group IB	Homo sapiens	68-84
2029536-6	1991	The dissociation constants for calmodulin and CBP estimated by fluorescence titrations were 36.0 and 29.9 nM for CBPb in the presence of Ca2+ and EGTA, respectively.	Egtazic Acid	146-150	calmodulin 1	Homo sapiens	31-41
2029536-6	1991	The dissociation constants for calmodulin and CBP estimated by fluorescence titrations were 36.0 and 29.9 nM for CBPb in the presence of Ca2+ and EGTA, respectively.	Egtazic Acid	146-150	CREB binding protein	Homo sapiens	46-49
2022306-9	1991	DiC8-induced rise in [Ca2+]i still occurred in the presence of the Ca(2+)-channel blocker verapamil or when the extracellular Ca2+ had been reduced from 2.5 mM to 30 nM by EGTA.	Egtazic Acid	172-176	carbonic anhydrase 2	Mesocricetus auratus	22-25
1902789-7	1991	Ca2+ influx after PAF stimulation could be blocked after 2 min by EGTA, but a further increase in the formation of 5-lipoxygenase metabolites was observed.	Egtazic Acid	66-70	PCNA clamp associated factor	Homo sapiens	18-21
1902789-8	1991	In contrast ionomycin-elicited 5-lipoxygenase activity could be stopped at any time shortly after EGTA addition.	Egtazic Acid	98-102	arachidonate 5-lipoxygenase	Homo sapiens	31-45
1901060-9	1991	The calcium chelator EGTA significantly inhibited the PAF-produced phosphorylation of the pp41 protein.	Egtazic Acid	21-25	PCNA clamp associated factor	Homo sapiens	54-57
1826835-3	1991	In this study we show that tau in extracts of Alzheimer"s disease brain can be separated into two fractions based upon its solubility (100,000 g x 1 h supernatant) in non-denaturing conditions (100 mM-Mes, pH 6.5, 0.5 mM-MgCl2, 1 mM-EGTA and 1 M-NaCl).	Egtazic Acid	233-237	microtubule associated protein tau	Homo sapiens	27-30
1900528-8	1991	Additions of EGTA or verapamil had a small effect on the peak height of serotonin-induced [Ca++]i elevation, but the [Ca++]i level declined more quickly to the basal level in treated compared with control cells.	Egtazic Acid	13-17	carbonic anhydrase 1	Rattus norvegicus	91-97
1708823-7	1991	Exposure to 0.05 mM-Mg2+ at low [Ca2+] (2 mM-free EGTA, pCa greater than 8.7) also induced Ca2+ release and depleted the SR. 3.	Egtazic Acid	50-54	mucin 7, secreted	Homo sapiens	20-23
2017153-2	1991	Activation of a 65-pS channel was evident in excised inside-out patches with the internal side of the membrane exposed to Ca2+ (0.2 mM); cessation of channel activity was immediate upon perfusion with ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid-containing solution.	Egtazic Acid	201-270	carbonic anhydrase 2	Homo sapiens	122-125
1713165-4	1991	Ruthenium red, a blocker of mitochondrial Ca2+ reuptake, potently increased 3,4-DAP-evoked [3H]NA release in Ca(2+)-free EGTA-containing medium.	Egtazic Acid	121-125	death-associated protein	Rattus norvegicus	80-83
2000951-6	1991	Inhibitory effects of ANG II on proximal tubular transport were still observed in a Ca2(+)-free perfusate containing ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, indicating that these effects do not require influx of Ca2+ from extracellular medium.	Egtazic Acid	117-186	angiotensinogen	Rattus norvegicus	22-28
1364828-9	1991	In Ca-free solution containing 2 mM EGTA, VIP inhibited the phasic contraction induced by 100 microM CCh, but not that induced by 30 mM caffeine.	Egtazic Acid	36-40	vasoactive intestinal peptide	Rattus norvegicus	42-45
1742874-6	1991	We perfused the cells with 10 mM EGTA to block changes in intracellular Ca2+ concentration.	Egtazic Acid	33-37	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	72-75
1708823-14	1991	In the presence of 1 mM-EGTA to chelate most of the released Ca2+, depolarizations in 10 mM-Mg2+ did not noticeably deplete the SR of Ca2+, whereas a single depolarization in 1 mM-Mg2+ (and 1 mM-EGTA) resulted in marked depletion.	Egtazic Acid	195-199	mucin 7, secreted	Homo sapiens	92-95
1847585-8	1991	With both alpha-thrombin and ADP, chelation of external calcium by EGTA (2 mM) reduced calcium response of individual cells.	Egtazic Acid	67-71	WD and tetratricopeptide repeats 1	Homo sapiens	10-32
18965142-2	1991	The determination of Fe(III) and Co(II) based on displacement of Fe(III) and Co(II) from their EGTA complexes by PAR, was used as a model system.	Egtazic Acid	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-39
18965142-2	1991	The determination of Fe(III) and Co(II) based on displacement of Fe(III) and Co(II) from their EGTA complexes by PAR, was used as a model system.	Egtazic Acid	95-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-83
1899970-4	1991	An acutely induced, constant hypocalcemic stimulus [0.32 mM decrement in ionized Ca (Ca2+) for 2 h] was developed in catheterized conscious adult and aged rats by ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) infusion using the Ca clamp technique.	Egtazic Acid	163-232	carbonic anhydrase 2	Rattus norvegicus	85-88
1645451-8	1991	As with most secretagogues, VIP-induced secretion was inhibited in the presence of either EGTA or a voltage-sensitive Ca2+ channel antagonist, PN200-110.	Egtazic Acid	90-94	vasoactive intestinal polypeptide	Mus musculus	28-31
19215446-4	1991	The transient induced by TRH was found to have a dual origin, one due to Ca(2+) mobilization from intracellular stores which was maintained in presence of EGTA (3mM) and verapamil (10 muM) and a plateau phase due to Ca(2+) influx from the extracellular media.	Egtazic Acid	155-159	thyrotropin releasing hormone	Homo sapiens	25-28
1846511-8	1991	Inhibition of AhR transformation, but not ligand or DNA binding, by EDTA and EGTA suggests that a chelatable divalent cation(s) may play a critical role in the transformation process.	Egtazic Acid	77-81	aryl hydrocarbon receptor	Rattus norvegicus	14-17
1904293-4	1991	When endothelial cells were bathed in nominally calcium-free solution containing 0.5 mM EGTA, bradykinin induced only a transient elevation of [Ca2+]i: the magnitude of this was significantly smaller than that obtained in the presence of extracellular calcium and the sustained phase was abolished.	Egtazic Acid	88-92	kininogen 1	Bos taurus	94-104
1904293-12	1991	In the presence of 1 mM extracellular calcium, treatment with the calcium chelator EGTA (2 mM; 1 min) had no effect on resting [Ca2+]i but the magnitude of the bradykinin-induced initial transient elevation of [Ca2+]i was significantly reduced.	Egtazic Acid	83-87	kininogen 1	Bos taurus	160-170
1908695-4	1991	Conversely, elimination of Ca2+ from the culture medium by EGTA, Ca2+ chelate agent, strongly inhibited t-PA production induced by p.peptone.	Egtazic Acid	59-63	plasminogen activator, tissue type	Homo sapiens	104-108
1829655-7	1991	WT31-induced T cell activation was Ca(2+)-dependent because the addition of EGTA to the medium inhibited DNA synthesis and CD25 antigen expression.	Egtazic Acid	76-80	interleukin 2 receptor subunit alpha	Homo sapiens	123-127
2060032-2	1991	Preliminary experiments have confirmed that the addition of EGTA (5 x 10(-3); 10(-2) M) to BWW medium decreased the intracellular calcium concentration ((Ca++)i) of spermatozoa, as measured in cells loaded with a fluorescent Ca++ indicator, Quin-2.	Egtazic Acid	60-64	carbonic anhydrase 1	Homo sapiens	154-160
2015619-7	1991	Treatment of the vesicles with 1 mM EGTA to remove calmodulin significantly reduced calmodulin content to 19.7 +/- 1.35 ng/mg.	Egtazic Acid	36-40	calmodulin 1	Homo sapiens	51-61
2015619-7	1991	Treatment of the vesicles with 1 mM EGTA to remove calmodulin significantly reduced calmodulin content to 19.7 +/- 1.35 ng/mg.	Egtazic Acid	36-40	calmodulin 1	Homo sapiens	84-94
2174064-5	1990	EGTA inhibited the cytochalasin B/fMLP-induced increment in [Ca]i and O2- production by 75% and 50%, respectively, and completely ablated the response to cytochalasin B/Con A, suggesting a role for extracellular as well as intracellular calcium in the respiratory burst.	Egtazic Acid	0-4	formyl peptide receptor 1	Homo sapiens	34-38
2036297-3	1991	The response to FMLP was partially inhibited (about 50%) in the absence of extracellular Ca2 (EGTA added).	Egtazic Acid	94-98	formyl peptide receptor 1	Homo sapiens	16-20
1899461-5	1991	The sustained response to ATP was abolished by superfusion with the Ca2(+)-free solution (with 1 mM EGTA), while the transient peak response was uninfluenced.	Egtazic Acid	100-104	carbonic anhydrase 2	Homo sapiens	68-71
1849250-6	1991	An initial fast component of PDS afterhyperpolarizations, which peaked about 60 ms after PDS onset, was reduced by EGTA but not affected by 8-Br-cAMP suggesting that the fast Ca2(+)-activated K+ current also contributed to the PDS afterhyperpolarizations.	Egtazic Acid	115-119	carbonic anhydrase 2	Rattus norvegicus	175-178
2147196-1	1990	The glycosylation inhibiting factor (GIF) was detected in EGTA extracts of the OVA-specific Ts cell hybridoma, 231F1 cells and 71B4 cells, which constitutively secrete GIF.	Egtazic Acid	58-62	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	4-35
2147196-1	1990	The glycosylation inhibiting factor (GIF) was detected in EGTA extracts of the OVA-specific Ts cell hybridoma, 231F1 cells and 71B4 cells, which constitutively secrete GIF.	Egtazic Acid	58-62	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	37-40
2147196-1	1990	The glycosylation inhibiting factor (GIF) was detected in EGTA extracts of the OVA-specific Ts cell hybridoma, 231F1 cells and 71B4 cells, which constitutively secrete GIF.	Egtazic Acid	58-62	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	168-171
2147196-6	1990	When the hybridoma was stimulated with OVA-pulsed APC, EGTA extracts of the cells contained GIF having affinity for OVA.	Egtazic Acid	55-59	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	92-95
2147196-7	1990	The binding of the OVA-binding GIF in the EGTA extracts to OVA-Sepharose was inhibited by a synthetic peptide, which corresponds to amino acid residues 307-317 in the OVA molecule and represents the epitope recognized by TCR on the cells.	Egtazic Acid	42-46	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	31-34
2173703-1	1990	We have recently shown that the Ca.EGTA and Mg.EDTA complexes, but not free Ca2+ or Mg2+, inhibit the liver glucose-6-phosphatase (Mithieux, G., Vega, F. V., Beylot, M., and Riou, J. P. (1990) J. Biol.	Egtazic Acid	35-39	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	108-129
2123095-7	1990	Purified 23 kDa protein shows characteristics typical of a Ca2(+)-binding protein; there is a mobility shift on SDS/polyacrylamide gels in the presence of EGTA, and Western blotting, followed by the use of the 45Ca2+ overlay technique, confirms that the 23 kDa protein does bind Ca2+.	Egtazic Acid	155-159	sarcoplasmic calcium-binding protein	Drosophila melanogaster	59-81
1760888-5	1991	Perfusion with a calcium free solution containing EGTA and A23187 stimulated renin release in the DOCA-salt hypertensive and control rats.	Egtazic Acid	50-54	renin	Rattus norvegicus	77-82
1686607-5	1991	The EGTA eluate from the affinity chromatography displays TGase activity at ten times that of the initial hemolysate.	Egtazic Acid	4-8	transglutaminase 1	Homo sapiens	58-63
1906437-5	1991	Both the calcium chelator, EGTA, and the intracellular calcium antagonist, TMB-8, inhibited TNF production stimulated by all agents, indicating that TNF stimulation by all agents was calcium dependent.	Egtazic Acid	27-31	tumor necrosis factor	Mus musculus	92-95
1906437-5	1991	Both the calcium chelator, EGTA, and the intracellular calcium antagonist, TMB-8, inhibited TNF production stimulated by all agents, indicating that TNF stimulation by all agents was calcium dependent.	Egtazic Acid	27-31	tumor necrosis factor	Mus musculus	149-152
1725414-6	1991	cAMP accumulation, induced by 100 nM ET-1, was blocked by extracellular Ca2+ chelator EGTA, the intracellular Ca2+ chelator TMB-8, and dihydropyridine Ca(2+)-channel antagonist nifedipine (p less than 0.05), whereas ET-1 inhibition of PGE2 release was unaffected.	Egtazic Acid	86-90	endothelin 1	Homo sapiens	37-41
20504745-9	1991	In calcium free solution (2 mM EGTA), ET-2 increased the efflux of (45)Ca from cells loaded to isotopic equilibrium (3 h) with (45)Ca.	Egtazic Acid	31-35	endothelin 2	Mus musculus	38-42
2148529-3	1990	Homogenization and further processing of heart in the presence of EGTA resulted in the recovery of annexin V (CaBP33) in the cytosolic fraction and in an EGTA-resistant, Triton X-100-soluble fraction from cardiac membranes.	Egtazic Acid	66-70	annexin A5	Homo sapiens	99-108
2124486-2	1990	The pretreatment of cells with EGTA (100 microM) plus arachidonic acid (15 microM), a condition which decreased TRH-responsive intracellular Ca2+ pools, eliminated the activity of TRH on burst PRL secretion (2 min) but did not alter that on sustained PRL secretion (30 min).	Egtazic Acid	31-35	thyrotropin releasing hormone	Rattus norvegicus	112-115
2124486-2	1990	The pretreatment of cells with EGTA (100 microM) plus arachidonic acid (15 microM), a condition which decreased TRH-responsive intracellular Ca2+ pools, eliminated the activity of TRH on burst PRL secretion (2 min) but did not alter that on sustained PRL secretion (30 min).	Egtazic Acid	31-35	thyrotropin releasing hormone	Rattus norvegicus	180-183
2124486-3	1990	However, the treatment of cells with EGTA, arachidonic acid and H-7 (300 microM), a potent inhibitor of protein kinase C (PKC), almost completely suppressed the activity of TRH for sustained PRL secretion.	Egtazic Acid	37-41	protein kinase C, gamma	Rattus norvegicus	104-120
2124486-3	1990	However, the treatment of cells with EGTA, arachidonic acid and H-7 (300 microM), a potent inhibitor of protein kinase C (PKC), almost completely suppressed the activity of TRH for sustained PRL secretion.	Egtazic Acid	37-41	protein kinase C, gamma	Rattus norvegicus	122-125
2124486-3	1990	However, the treatment of cells with EGTA, arachidonic acid and H-7 (300 microM), a potent inhibitor of protein kinase C (PKC), almost completely suppressed the activity of TRH for sustained PRL secretion.	Egtazic Acid	37-41	thyrotropin releasing hormone	Rattus norvegicus	173-176
2260673-9	1990	A Ca2(+)-activated potassium [K(Ca)] current was activated by application of methacholine (100 microM), or A23187 (1 microM), under conditions of low Ca2+ buffering capacity in the internal solution [0.3 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA)].	Egtazic Acid	207-276	carbonic anhydrase 2	Canis lupus familiaris	2-5
2260673-9	1990	A Ca2(+)-activated potassium [K(Ca)] current was activated by application of methacholine (100 microM), or A23187 (1 microM), under conditions of low Ca2+ buffering capacity in the internal solution [0.3 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA)].	Egtazic Acid	278-282	carbonic anhydrase 2	Canis lupus familiaris	2-5
2258699-3	1990	Pretreatment of these cell lines with M177 and polyclonal anti-MCP, which inhibit cofactor activity almost completely, resulted in effective C3 deposition immediately following addition of these cells to Mg2+/EGTA/human sera.	Egtazic Acid	209-213	CD46 molecule	Homo sapiens	63-66
2122977-9	1990	Cells pretreated with dithiothreitol, an alternate inducer of GRP78, also became tolerant to translational inhibition by Ca2+ ionophore or EGTA.	Egtazic Acid	139-143	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	62-67
2122977-10	1990	Amino acid incorporation in nonsecreting NS-1-cloned myeloma cells, which constitutively express high levels of GRP78 and its mRNA, resisted inhibition by EGTA, ionophore, and dithiothreitol.	Egtazic Acid	155-159	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	112-117
2124805-3	1990	The single cell [Ca2+]i assay revealed that in the presence of nifedipine (1 microM) or EGTA (1 mM), the peak [Ca2+]i declined more rapidly to the resting level in VIC-stimulated NG108-15 cells, indicating that the receptor-mediated intracellular Ca2+ mobilization is followed by Ca2+ influx through the nifedipine-sensitive Ca2+ channel.	Egtazic Acid	88-92	endothelin 2	Mus musculus	164-167
1702040-8	1990	The ability of GM1 to enhance neuritogenesis was diminished by EGTA or Ruthenium red.	Egtazic Acid	63-67	coenzyme Q10A	Mus musculus	15-18
2174064-9	1990	Third, following neutrophil priming with dioctanoylglycerol (diC8), maximal O2- production occurred in response to 0.015 microM fMLP or Con A without a rise in [Ca]i, and diC8/fMLP-induced O2- production was not inhibited by EGTA.	Egtazic Acid	225-229	formyl peptide receptor 1	Homo sapiens	128-132
2173554-0	1990	On the use of EGTA to assess the effect of Ca2+ on liver microsomal glucose-6-phosphatase.	Egtazic Acid	14-18	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	68-89
1980647-12	1990	Quisqualate and glutamate, but not the other EAA agonists, also increased [Ca2+]i after chelation of extracellular calcium with EGTA.	Egtazic Acid	128-132	carbonic anhydrase 2	Gallus gallus	75-78
1698459-5	1990	Phosphorylation of the exogenous substrate myelin basic protein by DEAE-resolved ovarian kinase showed the variant effector dependence, maximal in the presence of EGTA, phosphatidylserine and 1,2-diolein.	Egtazic Acid	163-167	myelin basic protein	Homo sapiens	43-63
1696888-10	1990	EGTA (2.5 mM) reduced the basal Indo-1 ratios and attenuated, but did not abolish, the initial increase in response to LHRH, consistent with the initial extracellular Ca2+ influx-independent phase of the response to LHRH.	Egtazic Acid	0-4	gonadotropin releasing hormone 1	Rattus norvegicus	119-123
2123288-5	1990	Binding of calmodulin occurs in the presence of 1 mM Ca 2+ and it can be eluted from the column with 4 mM EGTA.	Egtazic Acid	106-110	calmodulin 1	Homo sapiens	11-21
1696888-10	1990	EGTA (2.5 mM) reduced the basal Indo-1 ratios and attenuated, but did not abolish, the initial increase in response to LHRH, consistent with the initial extracellular Ca2+ influx-independent phase of the response to LHRH.	Egtazic Acid	0-4	gonadotropin releasing hormone 1	Rattus norvegicus	216-220
1696888-12	1990	This effect of NPY was also blocked by EGTA.	Egtazic Acid	39-43	neuropeptide Y	Rattus norvegicus	15-18
2115065-5	1990	Addition of EGTA to the assay mixture reduced LPL activity by 34-60% and when present in the collection medium, EGTA led to a reduction in enzyme activity greater than 90%.	Egtazic Acid	12-16	lipoprotein lipase	Mus musculus	46-49
1696912-3	1990	EGTA reverses Ca2+ stimulation but takes several seconds to act, indicating slow release of Ca2+ from the activation site possibly on the matrix side of the inner mitochondrial membrane.	Egtazic Acid	0-4	carbonic anhydrase 2	Rattus norvegicus	14-17
1696912-3	1990	EGTA reverses Ca2+ stimulation but takes several seconds to act, indicating slow release of Ca2+ from the activation site possibly on the matrix side of the inner mitochondrial membrane.	Egtazic Acid	0-4	carbonic anhydrase 2	Rattus norvegicus	92-95
2124177-3	1990	The inhibitory effects of bFGF and EGF on Nsp100 phosphorylation were prevented by pretreatment of PC12h cells with the calcium chelator, EGTA.	Egtazic Acid	138-142	fibroblast growth factor 2	Rattus norvegicus	26-30
2124177-3	1990	The inhibitory effects of bFGF and EGF on Nsp100 phosphorylation were prevented by pretreatment of PC12h cells with the calcium chelator, EGTA.	Egtazic Acid	138-142	epidermal growth factor like 1	Rattus norvegicus	35-38
2174905-8	1990	On chelation of free Ca2+, both GA2 and GA3 dissociated to form the EGTA stable binary complex (GA) with an apparent molecular mass of 140 kDa and free actin.	Egtazic Acid	68-72	electron transfer flavoprotein subunit alpha	Homo sapiens	32-35
1369299-8	1990	HAF was stable from pH 6 to 8 at 37 degrees C and up to 40 degrees C at pH 8.0 and the aggregation activity of HAF was maximum around pH 8 at 30 degrees C. The activity was not influenced by some saccharides, but it was inhibited by EDTA and EGTA: moreover HAF activity was restored by the addition of calcium ions.	Egtazic Acid	242-246	coagulation factor XII	Rattus norvegicus	0-3
1369299-8	1990	HAF was stable from pH 6 to 8 at 37 degrees C and up to 40 degrees C at pH 8.0 and the aggregation activity of HAF was maximum around pH 8 at 30 degrees C. The activity was not influenced by some saccharides, but it was inhibited by EDTA and EGTA: moreover HAF activity was restored by the addition of calcium ions.	Egtazic Acid	242-246	coagulation factor XII	Rattus norvegicus	111-114
1369299-8	1990	HAF was stable from pH 6 to 8 at 37 degrees C and up to 40 degrees C at pH 8.0 and the aggregation activity of HAF was maximum around pH 8 at 30 degrees C. The activity was not influenced by some saccharides, but it was inhibited by EDTA and EGTA: moreover HAF activity was restored by the addition of calcium ions.	Egtazic Acid	242-246	coagulation factor XII	Rattus norvegicus	111-114
2115065-7	1990	LPL activity in the enzyme collection medium after its removal from cell monolayers was stable at least up to 4 h at 0 degrees C and at 23 degrees C. Activity was progressively lost with increased temperatures: up to 40% loss at 37 degrees C in 4 h. Addition of EGTA to the above medium led to an enhanced rate of irreversible enzyme inactivation: 76-86% loss of activity in 4 h at 37 degrees C. No inactivation was observed at 0 degrees C and at 23 degrees C in the presence of EGTA.	Egtazic Acid	262-266	lipoprotein lipase	Mus musculus	0-3
2115065-7	1990	LPL activity in the enzyme collection medium after its removal from cell monolayers was stable at least up to 4 h at 0 degrees C and at 23 degrees C. Activity was progressively lost with increased temperatures: up to 40% loss at 37 degrees C in 4 h. Addition of EGTA to the above medium led to an enhanced rate of irreversible enzyme inactivation: 76-86% loss of activity in 4 h at 37 degrees C. No inactivation was observed at 0 degrees C and at 23 degrees C in the presence of EGTA.	Egtazic Acid	479-483	lipoprotein lipase	Mus musculus	0-3
2177198-5	1990	On the other hand, dexamethasone and indomethacin inhibited and, EGTA and TMB-8, which reduce intracellular Ca++ Levels, blocked IFN gamma induced PGE2 production, which suggested that the activation of phospholipase A2 and cyclooxygenase in Kupffer cells requires the elevation of intracellular Ca++ levels.	Egtazic Acid	65-69	interferon gamma	Mus musculus	129-138
2174905-8	1990	On chelation of free Ca2+, both GA2 and GA3 dissociated to form the EGTA stable binary complex (GA) with an apparent molecular mass of 140 kDa and free actin.	Egtazic Acid	68-72	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	40-43
2177198-5	1990	On the other hand, dexamethasone and indomethacin inhibited and, EGTA and TMB-8, which reduce intracellular Ca++ Levels, blocked IFN gamma induced PGE2 production, which suggested that the activation of phospholipase A2 and cyclooxygenase in Kupffer cells requires the elevation of intracellular Ca++ levels.	Egtazic Acid	65-69	phospholipase A2, group IB, pancreas	Mus musculus	203-219
1973186-4	1990	Further, we have causally related these events to the qualitative upregulation of CD11b/CD18, as exemplified by its inducible binding of factor X. Micromolar concentrations of ADP or ATP produce dose-dependent increase in monocyte cytosolic free [Ca2+]i through mobilization from intracellular stores coupled with a sustained, EGTA-sensitive, influx of Ca2+ from the external compartment.	Egtazic Acid	327-331	integrin subunit alpha M	Homo sapiens	82-87
1973186-4	1990	Further, we have causally related these events to the qualitative upregulation of CD11b/CD18, as exemplified by its inducible binding of factor X. Micromolar concentrations of ADP or ATP produce dose-dependent increase in monocyte cytosolic free [Ca2+]i through mobilization from intracellular stores coupled with a sustained, EGTA-sensitive, influx of Ca2+ from the external compartment.	Egtazic Acid	327-331	integrin subunit beta 2	Homo sapiens	88-92
2162839-5	1990	In the presence of EGTA, CaMK-(290-309) was phosphorylated exclusively on threonine residues (Km = 13 microM; Vmax = 211 nmol/min/mg).	Egtazic Acid	19-23	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	25-29
2115174-3	1990	The proteolytic processing of pre-IL-1 alpha was completely inhibited by EGTA.	Egtazic Acid	73-77	interleukin 1 alpha	Homo sapiens	34-44
1976198-7	1990	The increase in TH mRNA was inhibited by the chelation of calcium with 3 mM EGTA.	Egtazic Acid	76-80	tyrosine hydroxylase	Rattus norvegicus	16-18
2169076-8	1990	In the absence of extracellular calcium (EGTA 1 mM), ATP release caused by thrombin was inhibited.	Egtazic Acid	41-45	prothrombin	Oryctolagus cuniculus	75-83
1974859-5	1990	MSH binding in both tissues was abolished by EGTA and was increased dose dependently with elevation of free Ca2+ ion concentration.	Egtazic Acid	45-49	proopiomelanocortin	Rattus norvegicus	0-3
2161855-3	1990	The rate of dissociation of EGTA resistant, 1:1 gelsolin-actin complexes is more rapid in cells exposed to 10(-7) M fmlp than in cells exposed to 10(-9) M fmlp, and the extent of dissociation 10 s after activation depends upon the fmlp concentration.	Egtazic Acid	28-32	gelsolin	Homo sapiens	48-56
2161855-4	1990	Furthermore, 300 s after fmlp activation when F-actin content is decreasing, gelsolin reassociates with actin as evidenced by an increase in the amount of EGTA resistant, 1:1 gelsolin-actin complex.	Egtazic Acid	155-159	gelsolin	Homo sapiens	77-85
2161855-4	1990	Furthermore, 300 s after fmlp activation when F-actin content is decreasing, gelsolin reassociates with actin as evidenced by an increase in the amount of EGTA resistant, 1:1 gelsolin-actin complex.	Egtazic Acid	155-159	gelsolin	Homo sapiens	175-183
2253588-5	1990	An AVP-induced increase in [Ca2+]i was still demonstrable in cells pretreated with Ca2(+)-free medium containing 1 x 10(-3) M EGTA, or a blocker of cellular Ca2+ uptake, 5 x 10(-5) M verapamil.	Egtazic Acid	126-130	arginine vasopressin	Rattus norvegicus	3-6
1972774-7	1990	When cyclic GMP formation induced by agonists was assayed after the cells were exposed to 3 mM ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) for 2 min, the formation of cyclic GMP was not inhibited significantly; however, it was completely abolished after 30-min exposure to EGTA.	Egtazic Acid	95-164	5'-nucleotidase, cytosolic II	Mus musculus	12-15
1972774-7	1990	When cyclic GMP formation induced by agonists was assayed after the cells were exposed to 3 mM ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) for 2 min, the formation of cyclic GMP was not inhibited significantly; however, it was completely abolished after 30-min exposure to EGTA.	Egtazic Acid	95-164	5'-nucleotidase, cytosolic II	Mus musculus	207-210
1972774-7	1990	When cyclic GMP formation induced by agonists was assayed after the cells were exposed to 3 mM ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) for 2 min, the formation of cyclic GMP was not inhibited significantly; however, it was completely abolished after 30-min exposure to EGTA.	Egtazic Acid	166-170	5'-nucleotidase, cytosolic II	Mus musculus	12-15
1972774-7	1990	When cyclic GMP formation induced by agonists was assayed after the cells were exposed to 3 mM ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid (EGTA) for 2 min, the formation of cyclic GMP was not inhibited significantly; however, it was completely abolished after 30-min exposure to EGTA.	Egtazic Acid	306-310	5'-nucleotidase, cytosolic II	Mus musculus	12-15
2108137-6	1990	When cells were homogenized at Ca2+ concentrations expected in stimulated cells (230-450 nM), 60-70% of the phospholipase A2 activity was lost from the soluble fraction and became associated with the particulate fraction in a manner that was partly reversible with EGTA.	Egtazic Acid	265-269	phospholipase A2 group IB	Homo sapiens	108-124
2139332-3	1990	When glomeruli were incubated in a calcium free medium containing 2 mM EGTA, ANP suppressed stimulated renin release significantly at 5 x 10(-8) and 5 x 10(-9) M by 25% (p = 0.0204, and p = 0.0101, respectively).	Egtazic Acid	71-75	natriuretic peptide A	Rattus norvegicus	77-80
2139332-3	1990	When glomeruli were incubated in a calcium free medium containing 2 mM EGTA, ANP suppressed stimulated renin release significantly at 5 x 10(-8) and 5 x 10(-9) M by 25% (p = 0.0204, and p = 0.0101, respectively).	Egtazic Acid	71-75	renin	Rattus norvegicus	103-108
2158996-9	1990	We show that the glucose-6-phosphatase activity is: 1) increased in the presence of CaCl2 at concentrations higher than 10(-4) M and unaffected in the presence of CaCl2 at lower concentrations; 2) decreased in the presence of Ca-EGTA buffers yielding free Ca2+ concentrations higher than 10(-8) M; 3) the latter effect is not depending on free Ca2+ or free EGTA concentrations, but on Ca.EGTA complex concentration.	Egtazic Acid	229-233	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	17-38
2158996-9	1990	We show that the glucose-6-phosphatase activity is: 1) increased in the presence of CaCl2 at concentrations higher than 10(-4) M and unaffected in the presence of CaCl2 at lower concentrations; 2) decreased in the presence of Ca-EGTA buffers yielding free Ca2+ concentrations higher than 10(-8) M; 3) the latter effect is not depending on free Ca2+ or free EGTA concentrations, but on Ca.EGTA complex concentration.	Egtazic Acid	357-361	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	17-38
2157216-5	1990	The Ca2+ rise in oocytes induced by substance K was due to internal Ca2+ mobilization and was independent of external Ca2+, since it occurred in Ca2(+)-free medium fortified with 2 mM EGTA.	Egtazic Acid	184-188	tachykinin precursor 1 S homeolog	Xenopus laevis	36-47
2338527-6	1990	The binding of 125I-labelled calmodulin to these membranes increased significantly when the endogenous calmodulin in the membranes was removed by EGTA.	Egtazic Acid	146-150	calmodulin-3	Cavia porcellus	29-39
2338527-6	1990	The binding of 125I-labelled calmodulin to these membranes increased significantly when the endogenous calmodulin in the membranes was removed by EGTA.	Egtazic Acid	146-150	calmodulin-3	Cavia porcellus	103-113
2343036-3	1990	The hCG and hPL secretions elicited by the addition of extracellular Ca2+ were larger when placental explants were preincubated in alpha-calcium (no added calcium + EGTA) than in normo-calcium (1.5 mM).	Egtazic Acid	165-169	chorionic gonadotropin subunit beta 5	Homo sapiens	4-7
2336197-2	1990	After withdrawal of extracellular Ca2+ and addition of 1 mM EGTA (ethyleneglycol-bis (beta-aminoethyl ether) N,N,N",N"-tetraacetic acid) a short light flash still caused an increase in [Ca]o as measured with Ca2(+)-sensitive microelectrodes.	Egtazic Acid	60-64	carbonic anhydrase 2	Homo sapiens	208-211
2336197-2	1990	After withdrawal of extracellular Ca2+ and addition of 1 mM EGTA (ethyleneglycol-bis (beta-aminoethyl ether) N,N,N",N"-tetraacetic acid) a short light flash still caused an increase in [Ca]o as measured with Ca2(+)-sensitive microelectrodes.	Egtazic Acid	66-135	carbonic anhydrase 2	Homo sapiens	208-211
2343036-3	1990	The hCG and hPL secretions elicited by the addition of extracellular Ca2+ were larger when placental explants were preincubated in alpha-calcium (no added calcium + EGTA) than in normo-calcium (1.5 mM).	Egtazic Acid	165-169	galectin 1	Homo sapiens	12-15
2108678-3	1990	The pretreatment with 3 mM EGTA for 1 min caused a significant reduction in [Ca2+]i levels both of the basal (p less than 0.05) and BK-stimulated initial peak (p less than 0.001).	Egtazic Acid	27-31	kininogen 1	Homo sapiens	132-134
2108678-4	1990	However, the BK-stimulated initial peak was retained in magnitude for at least 5 min under the treatment with EGTA.	Egtazic Acid	110-114	kininogen 1	Homo sapiens	13-15
2108678-6	1990	The BK-stimulated Ca2+ transient, once having been completely inhibited by ionomycin (10(-6) M) in the presence of EGTA, was rapidly (within 2 min) recovered to the untreated level by replacing it with fresh medium containing 1.5 mM Ca2+.	Egtazic Acid	115-119	kininogen 1	Homo sapiens	4-6
2200794-3	1990	Substratum prepared by removal of the intact monolayer with 20 mM EGTA in PBS (EGTA-derived substratum) contains fibronectin and heparan sulfate proteoglycan, but no type IV collagen.	Egtazic Acid	79-83	fibronectin 1	Homo sapiens	113-124
2108240-9	1990	In Ca-Mg-free medium, EGTA caused a slight decrease in [Ca++]i.	Egtazic Acid	22-26	carbonic anhydrase 1	Rattus norvegicus	56-62
2108240-10	1990	The EGTA-stimulated release of dopamine and noradrenaline was blocked by La which also significantly blocked the decrease in [Ca++]i observed after the addition of EGTA.	Egtazic Acid	4-8	carbonic anhydrase 1	Rattus norvegicus	126-132
2108240-10	1990	The EGTA-stimulated release of dopamine and noradrenaline was blocked by La which also significantly blocked the decrease in [Ca++]i observed after the addition of EGTA.	Egtazic Acid	164-168	carbonic anhydrase 1	Rattus norvegicus	126-132
2182533-3	1990	The extent of degranulation elicited with GM-CSF was reduced but not abolished when PMNs were incubated with EGTA in calcium-free medium.	Egtazic Acid	109-113	colony stimulating factor 2	Homo sapiens	42-48
2404452-3	1990	Depletion of intracellular Ca2+ with ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid reduced the effect of ATP by 50% and completely abolished the stimulatory effect of vasopressin on adipocyte pyruvate dehydrogenase but had no effect on the stimulation induced by insulin or adenosine.	Egtazic Acid	37-101	arginine vasopressin	Homo sapiens	186-197
2105083-6	1990	The conversion of calmodulin is dependent upon the absence of Ca2+ (the presence of 1 mM ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid).	Egtazic Acid	89-153	calmodulin 1	Homo sapiens	18-28
2404452-3	1990	Depletion of intracellular Ca2+ with ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid reduced the effect of ATP by 50% and completely abolished the stimulatory effect of vasopressin on adipocyte pyruvate dehydrogenase but had no effect on the stimulation induced by insulin or adenosine.	Egtazic Acid	37-101	insulin	Homo sapiens	282-289
2177621-5	1990	In order to test such a possibility we studied the vasopressin-induced Ins(1,4,5)P3 accumulation, where intracellular calcium mobilization is artificially suppressed by incubating the cells with EGTA in the presence of ionomycin.	Egtazic Acid	195-199	arginine vasopressin	Homo sapiens	51-62
2346501-4	1990	The actin fraction eluted from a DNase-I column by KCl-EGTA solution underwent polymerization and bundling in vitro.	Egtazic Acid	55-59	deoxyribonuclease 1	Rattus norvegicus	33-40
2081097-4	1990	Unlike TPA-stimulated PKC activity, the pp60v-src-induced increase in PKC was readily extracted from membranes by EGTA.	Egtazic Acid	114-118	proline rich transmembrane protein 2	Homo sapiens	70-73
1688413-4	1990	hGRF-(1-29) increased GH release and 45Ca2+ efflux also after 30 min preperifusion in a calcium-depleted medium with 0.1 mM EGTA added during the last 5 min of preperifusion.	Egtazic Acid	124-128	growth hormone releasing hormone	Homo sapiens	0-4
2152940-7	1990	Cellular calcium was crucial to the FMLP effect since enhancement was decreased in cells incubated with EGTA or Quin2.	Egtazic Acid	104-108	formyl peptide receptor 1	Homo sapiens	36-40
2107159-3	1990	Further studies with native proenzyme preparations showed that proacrosin activation at pH 7.1 or 8.0 was significantly accelerated in the presence of CaM and EGTA (t1/2 = 23 min vs. 55 min for EGTA alone at pH 7.1), but not in the presence of Ca2+ (t1/2 = 73 min).	Egtazic Acid	159-163	acrosin	Homo sapiens	63-73
2107159-3	1990	Further studies with native proenzyme preparations showed that proacrosin activation at pH 7.1 or 8.0 was significantly accelerated in the presence of CaM and EGTA (t1/2 = 23 min vs. 55 min for EGTA alone at pH 7.1), but not in the presence of Ca2+ (t1/2 = 73 min).	Egtazic Acid	194-198	acrosin	Homo sapiens	63-73
2107159-3	1990	Further studies with native proenzyme preparations showed that proacrosin activation at pH 7.1 or 8.0 was significantly accelerated in the presence of CaM and EGTA (t1/2 = 23 min vs. 55 min for EGTA alone at pH 7.1), but not in the presence of Ca2+ (t1/2 = 73 min).	Egtazic Acid	194-198	calmodulin 1	Homo sapiens	151-154
2107159-5	1990	Finally, the authors demonstrated that acrosin hydrolyzed CaM rapidly and extensively in the presence of EGTA.	Egtazic Acid	105-109	acrosin	Homo sapiens	39-46
2107159-5	1990	Finally, the authors demonstrated that acrosin hydrolyzed CaM rapidly and extensively in the presence of EGTA.	Egtazic Acid	105-109	calmodulin 1	Homo sapiens	58-61
2107159-2	1990	CaM binding evaluated by the [125I]-CaM overlay procedure was shown to occur preferentially with both proacrosin and acrosin in the presence of EGTA; in the presence of Ca2+, the interaction was less intense.	Egtazic Acid	144-148	calmodulin 1	Homo sapiens	0-3
2107159-2	1990	CaM binding evaluated by the [125I]-CaM overlay procedure was shown to occur preferentially with both proacrosin and acrosin in the presence of EGTA; in the presence of Ca2+, the interaction was less intense.	Egtazic Acid	144-148	calmodulin 1	Homo sapiens	36-39
2107159-2	1990	CaM binding evaluated by the [125I]-CaM overlay procedure was shown to occur preferentially with both proacrosin and acrosin in the presence of EGTA; in the presence of Ca2+, the interaction was less intense.	Egtazic Acid	144-148	acrosin	Homo sapiens	102-112
2107159-2	1990	CaM binding evaluated by the [125I]-CaM overlay procedure was shown to occur preferentially with both proacrosin and acrosin in the presence of EGTA; in the presence of Ca2+, the interaction was less intense.	Egtazic Acid	144-148	acrosin	Homo sapiens	105-112
34177455-9	2021	However, leptin-induced depolarization still occurred in the presence of either BAPTA or EGTA suggesting that the calcium entry necessary to self-activate the TRPC1/5 complex is not blocked by the presence of BAPTA in hypothalamic neurons.	Egtazic Acid	89-93	leptin	Mus musculus	9-15
11570812-9	2001	EGTA and TLCK could inhibit cytochrome c release from the mitochondria.	Egtazic Acid	0-4	cytochrome c, somatic	Homo sapiens	28-40
34696912-10	2022	Mammary PTHLH expression was increased in EL cows, with highest expression observed in EL EGTA-infused cows.	Egtazic Acid	90-94	parathyroid hormone like hormone	Bos taurus	8-13
34346292-8	2021	The effect of forskolin on c-Myc expression and the level of Ser25 phosphorylated AnxA2 was abolished in the presence of EGTA.	Egtazic Acid	121-125	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	27-32
34346292-8	2021	The effect of forskolin on c-Myc expression and the level of Ser25 phosphorylated AnxA2 was abolished in the presence of EGTA.	Egtazic Acid	121-125	annexin A2	Rattus norvegicus	82-87
2216899-5	1990	Growth of AGS cells, in the presence of 0.1 or 0.5 mM EGTA (resulting in the loss of the extracellular Ca2+) was similar to that observed in the absence of EGTA, indicating that AGS cells were relatively insensitive to loss of extracellular Ca2+.	Egtazic Acid	54-58	carbonic anhydrase 2	Homo sapiens	103-106
25848051-6	2015	Similarly, in mouse dorsal root ganglion neurons, capsaicin-activated inward currents were inhibited significantly by a specific ANO1 antagonist, T16Ainh-A01 (A01), in the presence of a high concentration of EGTA but not in the presence of BAPTA [1,2-bis(o-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid].	Egtazic Acid	208-212	anoctamin 1, calcium activated chloride channel	Mus musculus	129-133
34917046-7	2021	To verify the regulation role of Yvc1 in the calcium concentration, we found that the addition of CaCl2 led to the worse viability, while the growth state was relieved under the treatment of EGTA in the cnb1Delta/Delta strain.	Egtazic Acid	191-195	Yvc1p	Saccharomyces cerevisiae S288C	33-37
34617508-5	2021	Wild type rods filled with high (10 mM) or low (0.5 mM) concentrations of the Ca2+-buffer EGTA created a readily releasable pool (RRP) of 87 synaptic vesicles (SVs) that emptied as a single kinetic phase with a tau < 0.4 msec.	Egtazic Acid	90-94	microtubule associated protein tau	Homo sapiens	211-214
34617508-6	2021	The lower concentration of EGTA accelerated Cav channel opening and facilitated release kinetics.	Egtazic Acid	27-31	caveolin 2	Homo sapiens	44-47
34335670-4	2021	The treatment of Arabidopsis seeds with calcium ions (Ca2+) increased the H2O2 levels in the seedlings under HS treatment, whereas treatment with a Ca2+ chelator (EGTA) inhibited it, indicating that CNGC6 may stimulate the accumulation of H2O2 in a manner dependent on an increase in cytosolic Ca2+ ((Ca2+)cyt).	Egtazic Acid	163-167	cyclic nucleotide-gated channel 6	Arabidopsis thaliana	199-204
34177455-9	2021	However, leptin-induced depolarization still occurred in the presence of either BAPTA or EGTA suggesting that the calcium entry necessary to self-activate the TRPC1/5 complex is not blocked by the presence of BAPTA in hypothalamic neurons.	Egtazic Acid	89-93	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	159-164
35510301-12	2022	EGTA and PKCi reduced eATP-induced IDO and IFNgamma expressions by hPDLCs, confirming the role of calcium signaling.	Egtazic Acid	0-4	indoleamine 2,3-dioxygenase 1	Homo sapiens	35-38
35510301-12	2022	EGTA and PKCi reduced eATP-induced IDO and IFNgamma expressions by hPDLCs, confirming the role of calcium signaling.	Egtazic Acid	0-4	interferon gamma	Homo sapiens	43-51
35038920-13	2022	When tight junctions were interrupted by treatment with EGTA, cells became susceptible to infection, with nectin-4 serving as a receptor.	Egtazic Acid	56-60	nectin cell adhesion molecule 4	Canis lupus familiaris	106-114