PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 14741251-3 2004 The selectivity of BACE 1 inhibitors versus cathepsin D and renin was enhanced 120-fold by replacing the hydrophobic propyl group with a hydrophilic propionic acid group. propionic acid 149-163 beta-secretase 1 Homo sapiens 19-25 14741251-3 2004 The selectivity of BACE 1 inhibitors versus cathepsin D and renin was enhanced 120-fold by replacing the hydrophobic propyl group with a hydrophilic propionic acid group. propionic acid 149-163 cathepsin D Homo sapiens 44-55 14741251-3 2004 The selectivity of BACE 1 inhibitors versus cathepsin D and renin was enhanced 120-fold by replacing the hydrophobic propyl group with a hydrophilic propionic acid group. propionic acid 149-163 renin Homo sapiens 60-65 14552786-2 2003 Triaryl compounds bearing an ortho-substituted propionic acid moiety were identified as potent EP3 antagonists based on the SAR described herein. propionic acid 47-61 prostaglandin E receptor 3 Homo sapiens 95-98 11357398-1 2001 Natural chlorins containing a residue of the nonesterified propionic acid in the pyrrole ring D were oxidized with 2,3-dichloro-5,6-dicyanobenzoquinone at C18 to yield exocyclic delta-lactones. propionic acid 59-73 Bardet-Biedl syndrome 9 Homo sapiens 155-158 12527992-1 2003 We used the rats in which one olfactory nerve had been transected and observed the odor (Propionic acid) -induced c-Fos immunoreactivity in the bulb at different times (2, 4, 8 weeks) after nerve transection. propionic acid 89-103 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 114-119 12237228-6 2002 Thus, the presence of the metal and propionic acid groups, but not the vinyl moieties, of heme are important structural features in assembly of nNOS. propionic acid 36-50 nitric oxide synthase 1 Homo sapiens 144-148 11518226-0 2001 Effect of chromium picolinate and chromium propionate on glucose and insulin kinetics of growing barrows and on growth and carcass traits of growing-finishing barrows. propionic acid 34-53 insulin Sus scrofa 69-76 11405642-1 2001 Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis. propionic acid 0-14 peroxisome proliferator activated receptor gamma Mus musculus 106-115 11405642-1 2001 Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis. propionic acid 0-14 peroxisome proliferator activated receptor alpha Mus musculus 121-130 11405642-1 2001 Propionic acid derivative 8, which was designed and synthesized based on putative pharmacophores of known PPARgamma- and PPARalpha-selective compounds, exhibits potent dual PPARalpha/gamma agonist activity as demonstrated by in vitro binding and dose overlap in the newly introduced EOB mouse model for glucose lowering and lipid/cholesterol homeostasis. propionic acid 0-14 peroxisome proliferator activated receptor alpha Mus musculus 173-182 9671652-3 1998 Four independent mutant eag alleles exhibited reduced antennal sensitivity to a subset of nine odorants, all having short aliphatic side chains: ethyl butyrate (EB), propionic acid, 2-butanone, and ethyl acetate. propionic acid 166-180 ether a go-go Drosophila melanogaster 24-27 10893303-4 2000 Compounds containing a propionic acid moiety at the C-3" position of the tetrahydroindole ring represented the most potent indolin-2-ones to inactivate the VEGF, FGF, and PDGF receptor kinases. propionic acid 23-37 vascular endothelial growth factor A Homo sapiens 156-160 10602697-2 1999 Three classes of 3-substituted indolin-2-ones containing propionic acid functionality attached to the pyrrole ring at the C-3 position of the core have been identified as catalytic inhibitors of the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) RTKs. propionic acid 57-71 vascular endothelial growth factor A Homo sapiens 199-233 10602697-2 1999 Three classes of 3-substituted indolin-2-ones containing propionic acid functionality attached to the pyrrole ring at the C-3 position of the core have been identified as catalytic inhibitors of the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) RTKs. propionic acid 57-71 vascular endothelial growth factor A Homo sapiens 235-239 9929608-2 1998 Three independent mutant alleles of eag revealed reduced antennal responsiveness in adult flies to a subset of odorants, all having short aliphatic side chains: ethyl butyrate (EB), propionic acid, 2-butanone and ethyl acetate (manuscript submitted). propionic acid 182-196 ether a go-go Drosophila melanogaster 36-39 11511809-5 2000 Radio thin-layer chromatography analyses of propionic acid-released sialic acids showed that the incorporation of radioactivity correlated with the formation of a radiolabelled species that co-migrated with authentic Neu4,5Ac2. propionic acid 44-58 neuraminidase 4 Equus caballus 217-226 10409221-7 1999 Intracellular acidification caused by 20 mM propionic acid (0.18 pH units) potentiated the stretch-induced (intra-atrial pressure from 1 to 4 mmHg) ANP secretion, causing a twofold secretion compared with nonacidotic controls. propionic acid 44-58 natriuretic peptide A Rattus norvegicus 148-151 9563070-8 1998 AE2-transfected cells demonstrated significantly enhanced transport activity for nicotinic acid, propionic acid, butyric acid, and valproic acid as well as benzoic acid compared with mock-transfected cells. propionic acid 97-111 solute carrier family 4 member 2 Homo sapiens 0-3 9263742-3 1997 was administered over 2 h. NHE activity was measured by quantifying cytosolic pH (pHi) recovery following acidification of the cells with propionic acid and by pH clamping at various pHi values between 7.2 and 5.8 using nigericin. propionic acid 138-152 solute carrier family 9 member C1 Homo sapiens 27-30 9262162-1 1997 Prior 2-deoxyglucose and c-fos studies have demonstrated increased metabolic activity in a rostral dorsomedial area of the olfactory bulb in response to the vapor of propionic acid. propionic acid 166-180 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 25-30 9344549-1 1997 In the present study we demonstrate that propionic acid (PA), a metabolite that accumulates in large amounts in propionic acidemia, is able to decrease in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulin. propionic acid 41-55 neurofilament medium chain Rattus norvegicus 216-220 9344549-1 1997 In the present study we demonstrate that propionic acid (PA), a metabolite that accumulates in large amounts in propionic acidemia, is able to decrease in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulin. propionic acid 41-55 neurofilament light chain Rattus norvegicus 225-229 9344549-1 1997 In the present study we demonstrate that propionic acid (PA), a metabolite that accumulates in large amounts in propionic acidemia, is able to decrease in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulin. propionic acid 57-59 neurofilament medium chain Rattus norvegicus 216-220 9344549-1 1997 In the present study we demonstrate that propionic acid (PA), a metabolite that accumulates in large amounts in propionic acidemia, is able to decrease in vitro incorporation of [32P]ATP into neurofilament subunits (NF-M and NF-L) and alpha- and beta-tubulin. propionic acid 57-59 neurofilament light chain Rattus norvegicus 225-229 8880917-1 1996 Point mutations in the human gene encoding coenzyme B12 (adenosylcobalamin)-dependent methylmalonyl-CoA mutase give rise to an inherited disorder of propionic acid metabolism termed mut methylmalonic aciduria. propionic acid 149-163 methylmalonyl-CoA mutase Homo sapiens 86-110 23604654-1 1996 The effect of processing steps as well preservatives used in French bread making namely propionic acid and/or potassium sorbate (0.2%) on the destruction of aflatoxins B1 and G1 was studied.Mixing and baking processes showed marked destruction of aflatoxins B1 and G1; being 71.2% and 52.5% for aflatoxin B1 after mixing and baking steps, while reaching 73.9% and 54.5% for aflatoxin G1. propionic acid 88-102 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 168-177 23604654-2 1996 Fermentation step caused additional 15.3% and 15.0% destruction of aflatoxins B1 and G1.On the other hand, aflatoxin B1 destruction was 79.2% and 50.7% when propionic acid was used and 75.3 and 56.7% in the presence of potassium sorbate and after mixing and baking steps respectively.Concerning aflatoxins G1 it was found that mixing and baking steps showed destruction of 81.9% and 53.4% in the presence of propionic acid and 75.1 and 49.4% in the presence of potassium sorbate in this respective order.Generally, it can be concluded that using propionic acid as preservative appeared to be more effective on the destruction of aflatoxins B1 and G1 than potassium sorbate in French bread making. propionic acid 157-171 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 640-649 7631810-3 1995 The model was used to analyze the acid-base responses of rabbit alveolar M phi to a weak acid (propionic acid) under conditions that favored V-ATPase-mediated effects (presence of 1 mM amiloride and nominal absence of CO2). propionic acid 95-109 glucose-6-phosphate isomerase Oryctolagus cuniculus 75-78 8793085-6 1996 It is concluded that c-fos expression induced by a sustained stimulation with propionic acid vapours is not only determined by the olfactory peripheral input but also by afferents of central origin. propionic acid 78-92 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 21-26 8883028-3 1996 The initial rate of pHi recovery immediately after intracellular acidification with 100 mmol/l propionic acid, representing the maximum Na+/H+ exchange activity, was significantly higher in lymphocytes from patients with mild chronic renal failure (7.10 +/- 0.52 dpHi/s, mean +/- SEM) when compared with control subjects (5.42 +/- 0.47 dpHi/s; p < 0.05). propionic acid 95-109 glucose-6-phosphate isomerase Homo sapiens 20-23 7498454-6 1995 A propionic acid group of the inhibitor would clash with the thrombin specific "60-insertion loop", thus conferring selectivity against thrombin. propionic acid 2-16 coagulation factor II, thrombin Bos taurus 61-69 7498454-6 1995 A propionic acid group of the inhibitor would clash with the thrombin specific "60-insertion loop", thus conferring selectivity against thrombin. propionic acid 2-16 coagulation factor II, thrombin Bos taurus 136-144 7631810-5 1995 M phi exposure to propionic acid caused a rapid fall in pHi. propionic acid 18-32 glucose-6-phosphate isomerase Oryctolagus cuniculus 2-5 7631810-5 1995 M phi exposure to propionic acid caused a rapid fall in pHi. propionic acid 18-32 glucose-6-phosphate isomerase Oryctolagus cuniculus 56-59 7631810-7 1995 Mathematical analyses showed that pHi recovery was hindered by persistent influx of propionic acid driven, in turn, by transporter-mediated H+ extrusion and propionate efflux. propionic acid 84-98 glucose-6-phosphate isomerase Oryctolagus cuniculus 34-37 8227627-1 1993 Milk protein secretion is changed by increasing the proportion of energy, mainly as propionic acid, or the availability of AA. propionic acid 84-98 Weaning weight-maternal milk Bos taurus 0-4 8145075-7 1994 Microsomal hydroxymethylglutaryl-CoA (HMG-CoA) reductase activity was slightly depressed in rats fed the propionic acid-supplemented diet, whereas it was enhanced by the beta-cyclodextrin diet in parallel to the activity of cholesterol 7 alpha-hydroxylase. propionic acid 105-119 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 11-56 8145075-7 1994 Microsomal hydroxymethylglutaryl-CoA (HMG-CoA) reductase activity was slightly depressed in rats fed the propionic acid-supplemented diet, whereas it was enhanced by the beta-cyclodextrin diet in parallel to the activity of cholesterol 7 alpha-hydroxylase. propionic acid 105-119 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 224-255 8258824-9 1993 Ionophores such as nigericin, CCCP, or propionic acid also lowered the pHi but did not inhibit the oxidative burst, indicating that the pHi drop was not the cause for this inhibition. propionic acid 39-53 glucose-6-phosphate isomerase Homo sapiens 71-74 7698503-9 1995 Arginine, theophylline, and propionic acid increased insulin secretion from freshly isolated islets at 3.3 and 14 mmol/l glucose, but not at 25 mmol/l glucose. propionic acid 28-42 insulin Bos taurus 53-60 8392962-3 1993 Cell extract from propionic acid bacteria also possessed the antimutagenic activity, only partially depending on the SOD activity. propionic acid 18-32 superoxide dismutase 1 Homo sapiens 117-120 34958905-5 2022 VFA was composed mainly of acetic acid, but propionic acid increased at pH 9. propionic acid 44-58 phenylalanine hydroxylase Homo sapiens 72-74 8453036-1 1993 Using a selective monoclonal Fos antibody, we have studied the expression of the c-fos proto-oncogene in the olfactory bulb of awake rats stimulated with propionic acid vapours. propionic acid 154-168 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 81-86 1325517-6 1992 METHODS: Platelets were loaded with the intracellular pH (pHi) indicator 2"-7"-bis-carboxyethyl-5(6)-carboxyfluorescein (BCECF) and acidified by propionic acid. propionic acid 145-159 glucose-6-phosphate isomerase Homo sapiens 58-61 2175811-1 1990 The photoreactive analogue of vasopressin, [1-(3-mercapto)propionic acid, 8-(N6-4-azidophenyl-amidino)lysine] vasopressin (apa-LVP) could be used to elicit stimulation of cAMP production in LLC-PK renal epithelial cells, detectable up to 24 h after photoactivation by flash photolysis. propionic acid 57-72 vasopressin Sus scrofa 30-41 2175811-1 1990 The photoreactive analogue of vasopressin, [1-(3-mercapto)propionic acid, 8-(N6-4-azidophenyl-amidino)lysine] vasopressin (apa-LVP) could be used to elicit stimulation of cAMP production in LLC-PK renal epithelial cells, detectable up to 24 h after photoactivation by flash photolysis. propionic acid 57-72 vasopressin Sus scrofa 110-121 8468648-4 1993 Intraluminal instillation of a solution of casein (10 mg/mL) and calcium gluconate (50 mg/mL) in saline acidified to pH 4.0 with propionic acid resulted in a rapid and prolonged increase in serum I-FABP from a baseline of < or = 4.0 ng/mL to 171 +/- 40 ng/mL. propionic acid 129-143 fatty acid binding protein 2 Rattus norvegicus 196-202 8468648-5 1993 Instillation of the same electrolyte solution with either casein or propionic acid alone resulted in a less dramatic elevation of serum I-FABP to 19 +/- 4 ng/mL and 76 +/- 30 ng/mL, respectively. propionic acid 68-82 fatty acid binding protein 2 Rattus norvegicus 136-142 34926702-6 2021 An AR mouse model was developed to test the role of PA in stabilizing the IL-10 expression in B cells. propionic acid 52-54 interleukin 10 Mus musculus 74-79 34926702-8 2021 Serum PA levels were positively associated with peripheral CD5+ B cell frequency in AR patients; the CD5+ B cells were also IL-10+. propionic acid 6-8 CD5 molecule Homo sapiens 59-62 34926702-9 2021 The spontaneous IL-10 mRNA decay was observed in B cells, which was prevented by the presence of PA through activating GPR43. propionic acid 97-99 interleukin 10 Homo sapiens 16-21 34926702-9 2021 The spontaneous IL-10 mRNA decay was observed in B cells, which was prevented by the presence of PA through activating GPR43. propionic acid 97-99 free fatty acid receptor 2 Homo sapiens 119-124 34926702-10 2021 PA counteracted the effects of Tristetraprolin (TTP) on inducing IL-10 mRNA decay in B cells through the AKT/T-bet/granzyme B pathway. propionic acid 0-2 ZFP36 ring finger protein Homo sapiens 31-46 34926702-10 2021 PA counteracted the effects of Tristetraprolin (TTP) on inducing IL-10 mRNA decay in B cells through the AKT/T-bet/granzyme B pathway. propionic acid 0-2 interleukin 10 Homo sapiens 65-70 34926702-10 2021 PA counteracted the effects of Tristetraprolin (TTP) on inducing IL-10 mRNA decay in B cells through the AKT/T-bet/granzyme B pathway. propionic acid 0-2 AKT serine/threonine kinase 1 Homo sapiens 105-108 34926702-10 2021 PA counteracted the effects of Tristetraprolin (TTP) on inducing IL-10 mRNA decay in B cells through the AKT/T-bet/granzyme B pathway. propionic acid 0-2 T-box transcription factor 21 Homo sapiens 109-114 34926702-10 2021 PA counteracted the effects of Tristetraprolin (TTP) on inducing IL-10 mRNA decay in B cells through the AKT/T-bet/granzyme B pathway. propionic acid 0-2 granzyme B Homo sapiens 115-125 34926702-11 2021 Administration of Yupinfeng San, a Chinese traditional medical formula, or indole-3-PA, induced PA production by intestinal bacteria to stabilize the IL-10 expression in B cells, which promoted the allergen specific immunotherapy, and efficiently alleviated experimental AR. propionic acid 96-98 interleukin 10 Homo sapiens 150-155 34926702-13 2021 The serum lower PA levels are associated with the lower frequency of CD5+ B cells in AR patients. propionic acid 16-18 CD5 molecule Homo sapiens 69-72 35629867-4 2022 After the degassing treatment, the degradation of the HSC ink was suppressed, and the concentrations of acetic acid, propionic acid, and propyl propionate plummeted from 0.0898 wt.%, 0.00224 wt.%, and 0.00046 wt.% to 0.0025 wt.%, 0.0126 wt.%, and 0.0003 wt.%, respectively. propionic acid 117-131 fucosyltransferase 1 (H blood group) Homo sapiens 54-57 34642951-6 2021 Additionally, after fermentation for 48 hr, MOP-2 could significantly improve the production of short-chain fatty acids, especially n-butyric acid, acetic acid, propionic acid, and n-valeric acid. propionic acid 161-175 endothelial PAS domain protein 1 Homo sapiens 44-49 34835972-8 2021 Ganpu tea at the lowest concentrations showed positive effects on the concentrations of SCFAs such as acetic acid and propionic acid, whereas the concentration of butyric acid was decreased. propionic acid 118-132 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 6-9 34608511-10 2021 In Cr-supplemented bucks, there was a trend for higher ADF digestibility. propionic acid 3-5 destrin, actin depolymerizing factor Homo sapiens 55-58 34597388-5 2022 Further, PA increased regulatory T-cell numbers and interleukin (IL)-10 levels in the intestinal microenvironment, which in turn suppressed the expression of Niemann-Pick C1-like 1 (Npc1l1), a major intestinal cholesterol transporter. propionic acid 9-11 interleukin 10 Homo sapiens 52-71 34597388-5 2022 Further, PA increased regulatory T-cell numbers and interleukin (IL)-10 levels in the intestinal microenvironment, which in turn suppressed the expression of Niemann-Pick C1-like 1 (Npc1l1), a major intestinal cholesterol transporter. propionic acid 9-11 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 182-188 34597388-10 2022 CONCLUSION: Our findings reveal a novel immune-mediated pathway linking the gut microbiota-derived metabolite PA with intestinal Npc1l1 expression and cholesterol homeostasis. propionic acid 110-112 NPC1 like intracellular cholesterol transporter 1 Homo sapiens 129-135 34476820-5 2021 Besides, brain levels of anti-apoptotic Bcl-2 decreased, whereas pro-apoptotic Bax, antioxidant Nrf2, and HO-1 levels in brain increased compared with PPA (p < .05). propionic acid 151-154 BCL2, apoptosis regulator Rattus norvegicus 40-45 34476820-5 2021 Besides, brain levels of anti-apoptotic Bcl-2 decreased, whereas pro-apoptotic Bax, antioxidant Nrf2, and HO-1 levels in brain increased compared with PPA (p < .05). propionic acid 151-154 BCL2 associated X, apoptosis regulator Rattus norvegicus 79-82 34476820-5 2021 Besides, brain levels of anti-apoptotic Bcl-2 decreased, whereas pro-apoptotic Bax, antioxidant Nrf2, and HO-1 levels in brain increased compared with PPA (p < .05). propionic acid 151-154 NFE2 like bZIP transcription factor 2 Rattus norvegicus 96-100 34476820-5 2021 Besides, brain levels of anti-apoptotic Bcl-2 decreased, whereas pro-apoptotic Bax, antioxidant Nrf2, and HO-1 levels in brain increased compared with PPA (p < .05). propionic acid 151-154 heme oxygenase 1 Rattus norvegicus 106-110 34562183-11 2022 Interestingly, insulin therapy reduced MDA and IL-6 levels and increased GST, GSH, and vitamin C levels in brain homogenates of neonatal rats from mothers with T1D receiving insulin therapy compared to the PPA-treated group. propionic acid 206-209 interleukin 6 Rattus norvegicus 47-51 34062420-4 2021 In this study, the therapeutic efficacy of propionic acid- and butyric acid-based self-assembling nanoparticles (PNP/BNP) was evaluated in a mouse model of type 2 diabetes mellitus through ad libitum drinking. propionic acid 43-57 natriuretic peptide type B Mus musculus 117-120 34312159-2 2021 Our preclinical studies demonstrated exogenous PA increases glucagon, norepinephrine, and endogenous glucose production (EGP). propionic acid 47-49 glucagon Homo sapiens 60-68 34312159-6 2021 RESULTS: PA, as compared with placebo, significantly increased: (1) glucagon and norepinephrine during protocol 1; (2) glucagon, norepinephrine, and epinephrine under euglycemic conditions in protocol 2; and (3) norepinephrine, epinephrine, and EGP under hypoglycemic conditions in protocol 2. propionic acid 9-11 glucagon Homo sapiens 68-76 34312159-6 2021 RESULTS: PA, as compared with placebo, significantly increased: (1) glucagon and norepinephrine during protocol 1; (2) glucagon, norepinephrine, and epinephrine under euglycemic conditions in protocol 2; and (3) norepinephrine, epinephrine, and EGP under hypoglycemic conditions in protocol 2. propionic acid 9-11 glucagon Homo sapiens 119-127 34312159-7 2021 CONCLUSION: Oral consumption of PA leads to inappropriate activation of the insulin counterregulatory hormonal network. propionic acid 32-34 insulin Homo sapiens 76-83 34401092-6 2021 Dramatic increase of Na+ and K+ concentrations together with a decrease of GABA and IL-6 and an elevation of glutamate levels in PPA-treated rat"s pups confirmed the neurotoxicity effect of PPA. propionic acid 129-132 interleukin 6 Rattus norvegicus 84-88 34401092-6 2021 Dramatic increase of Na+ and K+ concentrations together with a decrease of GABA and IL-6 and an elevation of glutamate levels in PPA-treated rat"s pups confirmed the neurotoxicity effect of PPA. propionic acid 190-193 interleukin 6 Rattus norvegicus 84-88 35628613-7 2022 Additionally, catecholamine pretreatment blocked propionic acid/FFAR3 signaling via PKA-dependent activation of RGS4 in H9c2 cardiomyocytes. propionic acid 49-63 free fatty acid receptor 3 Mus musculus 64-69 35628613-7 2022 Additionally, catecholamine pretreatment blocked propionic acid/FFAR3 signaling via PKA-dependent activation of RGS4 in H9c2 cardiomyocytes. propionic acid 49-63 regulator of G-protein signaling 4 Mus musculus 112-116 34384873-8 2021 SYP levels were dramatically decreased in PPA-treated rats with simultaneous astrogliosis, suggesting reduced synaptic plasticity. propionic acid 42-45 synaptophysin Rattus norvegicus 0-3 34384873-9 2021 MT-III expression was deregulated in PPA-treated rats. propionic acid 37-40 metallothionein 3 Rattus norvegicus 0-6 34745222-6 2021 Additionally, Nsf loss led to a decrease in membrane SERT expression in the raphe and accumulation of glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors at the synaptic membrane surface in the hippocampal CA1 region. propionic acid 155-169 N-ethylmaleimide sensitive fusion protein Mus musculus 14-17 34252589-3 2021 In the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) glutamate receptor GluA2 subunit, A-I editing in the Q607R site leads to dramatic changes in function, making the receptor channel calcium-impermeable. propionic acid 50-64 glutamate ionotropic receptor AMPA type subunit 2 Rattus norvegicus 91-96 34531745-11 2021 More interestingly, the content level of SCFAs such as propionic acid and butyric acid was increased after ACE administration, which further mediates intestinal SDF-1/CXCR4 signalling pathway to repair the integrity of the intestinal barrier, decrease Cyclin D1 and C-myc expressions, eventually suppress the tumor the growth and metastasis of colon cancer. propionic acid 55-69 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus 107-110 34443546-6 2021 Moreover, PA inhibits NF-kappaB and AKT/mTOR signaling pathways and induces LC3B protein levels, resulting in autophagy. propionic acid 10-12 nuclear factor kappa B subunit 1 Homo sapiens 22-31 34443546-6 2021 Moreover, PA inhibits NF-kappaB and AKT/mTOR signaling pathways and induces LC3B protein levels, resulting in autophagy. propionic acid 10-12 AKT serine/threonine kinase 1 Homo sapiens 36-39 34443546-6 2021 Moreover, PA inhibits NF-kappaB and AKT/mTOR signaling pathways and induces LC3B protein levels, resulting in autophagy. propionic acid 10-12 mechanistic target of rapamycin kinase Homo sapiens 40-44 34443546-6 2021 Moreover, PA inhibits NF-kappaB and AKT/mTOR signaling pathways and induces LC3B protein levels, resulting in autophagy. propionic acid 10-12 microtubule associated protein 1 light chain 3 beta Homo sapiens 76-80 35112609-7 2021 Compared with OS0 lambs, supplemental PUFA in OS30 lambs tended to decrease total SCFA concentration with decreased acetic and increased propionic acid concentrations. propionic acid 137-151 PUFA Ovis aries 38-42 35572528-7 2022 The microbial gene functions related to PA biosynthesis were much higher in the fecal microbiome of the ID group compared to the CD. propionic acid 40-42 cathepsin D Mus musculus 129-131 35572528-10 2022 Furthermore, PA suppressed the secretion of inflammatory cytokines from peritoneal macrophages stimulated in vitro through TLR-4 with high-mobility group box 1 protein (HMGB-1), known to be released from apoptotic liver cells during the IR insult. propionic acid 13-15 toll-like receptor 4 Mus musculus 123-128 35572528-10 2022 Furthermore, PA suppressed the secretion of inflammatory cytokines from peritoneal macrophages stimulated in vitro through TLR-4 with high-mobility group box 1 protein (HMGB-1), known to be released from apoptotic liver cells during the IR insult. propionic acid 13-15 high mobility group box 1 Mus musculus 134-159 35572528-10 2022 Furthermore, PA suppressed the secretion of inflammatory cytokines from peritoneal macrophages stimulated in vitro through TLR-4 with high-mobility group box 1 protein (HMGB-1), known to be released from apoptotic liver cells during the IR insult. propionic acid 13-15 high mobility group box 1 Mus musculus 169-175 35453270-9 2022 Moreover, BGL elevated the abundance of Lactobacillus and the concentration of propanoic acid in colon in the ETEC-challenged pigs (p < 0.05). propionic acid 79-93 ETEC Sus scrofa 110-114 35390743-8 2022 In addition, short-chain fatty acids (SCFAs), including acetic acid, propionic acid and n-butyric acid, were significantly increased after LEP administration. propionic acid 69-83 leptin Mus musculus 139-142 35328722-6 2022 Four different FFAR types are known to date, with FFAR1 (formerly known as GPR40) and FFAR4 (formerly known as GPR120) mediating long- and medium-chain FFA actions, while FFAR3 (formerly GPR41) and FFAR2 (formerly GPR43) are essentially the SCFA receptors (SCFARs), responding to all SCFAs, including acetic acid, propionic acid, and butyric acid. propionic acid 314-328 free fatty acid receptor 1 Homo sapiens 50-55 35328722-6 2022 Four different FFAR types are known to date, with FFAR1 (formerly known as GPR40) and FFAR4 (formerly known as GPR120) mediating long- and medium-chain FFA actions, while FFAR3 (formerly GPR41) and FFAR2 (formerly GPR43) are essentially the SCFA receptors (SCFARs), responding to all SCFAs, including acetic acid, propionic acid, and butyric acid. propionic acid 314-328 free fatty acid receptor 4 Homo sapiens 86-91 35328722-6 2022 Four different FFAR types are known to date, with FFAR1 (formerly known as GPR40) and FFAR4 (formerly known as GPR120) mediating long- and medium-chain FFA actions, while FFAR3 (formerly GPR41) and FFAR2 (formerly GPR43) are essentially the SCFA receptors (SCFARs), responding to all SCFAs, including acetic acid, propionic acid, and butyric acid. propionic acid 314-328 free fatty acid receptor 4 Homo sapiens 111-117 35267913-6 2022 Both bean diets resulted in higher formation of all cecal SCFAs (higher proportion of propionic acid and lower proportion of acetic acid) and higher plasma trimethylamine N-oxide concentrations compared with the high fat diet. propionic acid 86-100 brain expressed, associated with Nedd4, 1 Mus musculus 5-9 35094316-10 2022 Moreover, Bifidobacteria treatment rescued the PPA-induced increase in IFN-gamma levels. propionic acid 47-50 interferon gamma Rattus norvegicus 71-80 35103058-10 2022 Interestingly, PA exerted a more pronounced lowering effect on ATF6, while combined treatment restored ATF6 to control. propionic acid 15-17 activating transcription factor 6 Rattus norvegicus 63-67 35103058-10 2022 Interestingly, PA exerted a more pronounced lowering effect on ATF6, while combined treatment restored ATF6 to control. propionic acid 15-17 activating transcription factor 6 Rattus norvegicus 103-107 35103058-13 2022 Despite PA treatment leading to a further 8.9-fold Iba1 elevation, PA+metformin caused the Iba1 decline vs. metformin and PA treatment. propionic acid 8-10 allograft inflammatory factor 1 Rattus norvegicus 51-55 35103058-13 2022 Despite PA treatment leading to a further 8.9-fold Iba1 elevation, PA+metformin caused the Iba1 decline vs. metformin and PA treatment. propionic acid 67-69 allograft inflammatory factor 1 Rattus norvegicus 51-55 35103058-13 2022 Despite PA treatment leading to a further 8.9-fold Iba1 elevation, PA+metformin caused the Iba1 decline vs. metformin and PA treatment. propionic acid 67-69 allograft inflammatory factor 1 Rattus norvegicus 91-95 35103058-14 2022 GFAP level did not change in T2DM but rose in metformin and PA groups vs. control. propionic acid 60-62 glial fibrillary acidic protein Rattus norvegicus 0-4 35103058-15 2022 PA+metformin administration diminished GFAP vs. PA. T2DM-induced changes were associated with dramatically decreased ZO-1 levels, while PA treatment increased it almost to control values. propionic acid 136-138 glial fibrillary acidic protein Rattus norvegicus 39-43 3304416-3 1987 Plasma insulin responses to propionic acid, glucose or casein were recorded. propionic acid 28-42 insulin Bos taurus 7-14 2472754-5 1989 To determine the usefulness of thin-layer chromatography in phosphoamino acid analysis, the propionic acid/ammonium hydroxide/isopropyl alcohol solution was used to characterize phosphorylated residues in a plasma membrane protein which is a substrate for the insulin receptor kinase, in insulin receptor phosphorylated histone H2B, and in an in vivo phosphorylated 90000-Da protein from IM9 cells. propionic acid 92-106 insulin receptor Homo sapiens 260-276 2472754-5 1989 To determine the usefulness of thin-layer chromatography in phosphoamino acid analysis, the propionic acid/ammonium hydroxide/isopropyl alcohol solution was used to characterize phosphorylated residues in a plasma membrane protein which is a substrate for the insulin receptor kinase, in insulin receptor phosphorylated histone H2B, and in an in vivo phosphorylated 90000-Da protein from IM9 cells. propionic acid 92-106 insulin receptor Homo sapiens 288-304 3345846-0 1988 Bisfunction of propionic acid on purified rat liver beta-ureidopropionase. propionic acid 15-29 beta-ureidopropionase 1 Rattus norvegicus 52-73 3345846-1 1988 Propionic acid and isobutyric acid, which are structural analogues of N-carbamoyl-beta-alanine and N-carbamoyl-beta-aminoisobutyric acid, respectively, acted as an allosteric activator as well as a competitive inhibitor of purified rat liver beta-ureidopropionase. propionic acid 0-14 beta-ureidopropionase 1 Rattus norvegicus 242-263 3304416-6 1987 When part of the propionic acid was infused into the rumen in a twice-daily 3 h dose and the remainder infused continuously with acetic and butyric acids and casein, there were large increases in the concentrations of propionic acid and insulin in the jugular blood. propionic acid 17-31 insulin Bos taurus 237-244 3304416-7 1987 When glucose, corresponding in energy to that supplied by the intermittent propionic acid infusions was similarly infused, the plasma levels of glucose and insulin were increased. propionic acid 75-89 insulin Bos taurus 156-163 3115599-1 1987 The addition of propionic acid to rabbit neutrophils causes cell acidification and increases the amount of actin associated with the cytoskeleton. propionic acid 16-30 actin Oryctolagus cuniculus 107-112 3115599-5 1987 Pretreatment of the cells with pertussis toxin inhibits the propionic acid-produced increase in cytoskeletal actin but not the decrease in intracellular pH. propionic acid 60-74 actin Oryctolagus cuniculus 109-114 7046164-7 1982 In addition to potent in vitro immunosuppressive properties, supplementation of drinking water with BA or PA resulted in prolongation of full-thickness skin grafts in DBA/2 (H-2d) to C57BL/6 (H-2b) donor-recipient combinations. propionic acid 106-108 DBA2 Homo sapiens 167-172 3511352-7 1986 The addition of 20 mmol/L propionic acid to 2.8 mmol/L glucose reduced pHi to 6.85 +/- .05, whereas 20 mmol/L NH4Cl increased pHi to 7.27 +/- .07. propionic acid 26-40 glucose-6-phosphate isomerase Rattus norvegicus 71-74 6747042-5 1984 Data support the glucogenic theory that propionic acid either directly or through gluconeogenesis stimulates insulin secretion, which in turn inhibits release of fatty acids from adipose tissue, resulting in milk fat depression. propionic acid 40-54 insulin Capra hircus 109-116 7046164-7 1982 In addition to potent in vitro immunosuppressive properties, supplementation of drinking water with BA or PA resulted in prolongation of full-thickness skin grafts in DBA/2 (H-2d) to C57BL/6 (H-2b) donor-recipient combinations. propionic acid 106-108 H2B clustered histone 21 Homo sapiens 192-196 318344-0 1978 A comparison of the malate dehydrogenase of the propionic acid bacteria with the mammalian soluble and mitochondrial isoenzymes. propionic acid 48-62 malic enzyme 1 Homo sapiens 20-40 656461-5 1978 This suggests that anhydride leghemoglobin has a conformation with a covalent attachment via propionic acid side chain to lysine-57 and the sixth coordination position of the heme iron occupied by the distal histidine at position 61. propionic acid 93-107 leghemoglobin A Glycine max 29-42 4306751-0 1969 The role of propionic acid as a precursor of methylmalonic acid in normal and vitamin B12-deficient man. propionic acid 12-26 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 86-89 5493858-4 1970 Propionic acid eluted 60-100% of the antibody adsorbed by Sepharose-myoglobin, and 60-90% of the eluted protein was precipitable antibody. propionic acid 0-14 myoglobin Physeter catodon 68-77 4462604-0 1974 The effect of dietary propionic acid on the requirement of chicks for vitamin B12. propionic acid 22-36 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 78-81 33906504-0 2021 Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism. propionic acid 142-156 smoothened, frizzled class receptor Rattus norvegicus 0-3 13512267-0 1958 [Effect of propionic acid on the activity of diluted catalase solutions]. propionic acid 11-25 catalase Homo sapiens 53-61 33961345-1 2021 The choice of TiO 2 crystal phase, i.e., anatase, rutile or brookite, greatly influences catalyst performance in the gas-phase ketonization of small volatile fatty acids, such as acetic acid and propionic acid. propionic acid 195-209 PAXIP1 associated glutamate rich protein 1 Homo sapiens 117-120 33243008-2 2021 The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected. propionic acid 57-71 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 82-87 33243008-2 2021 The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected. propionic acid 57-71 glutamate ionotropic receptor AMPA type subunit 1 Rattus norvegicus 97-124 33243008-2 2021 The levels of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) subunit glutamate receptor (GluR) 1 and GluR2/3 in CA1 region of melamine-treated rats, which were intragastric treated with 300 mg/kg/day for 4 weeks, were detected. propionic acid 57-71 carbonic anhydrase 1 Rattus norvegicus 140-143 33906504-0 2021 Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism. propionic acid 142-156 sonic hedgehog signaling molecule Rattus norvegicus 4-7 33121928-7 2021 The propionic acid-class NSAIDs were conjugated with CoA by recombinant human ACSL1. propionic acid 4-18 acyl-CoA synthetase long chain family member 1 Homo sapiens 78-83 33393951-8 2021 In mice, the KGM + F1-7 mixture reduced the tryptophan level and increased the levels of tryptamine, acetic acid, propionic acid, butyric acid and valeric acid. propionic acid 114-128 cytokine inducible SH2-containing protein Mus musculus 19-23 33121928-10 2021 In conclusion, we found that propionic acid-class NSAIDs could be conjugated to CoA by ACSL1 in the human liver to form CoA conjugates, which likely cause toxicity by protein adduct formation. propionic acid 29-43 acyl-CoA synthetase long chain family member 1 Homo sapiens 87-92 33596426-4 2021 MC-SST synaptic transmission undergoes long-term potentiation (LTP), requiring Gria2-lacking Ca2+-permeable anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (Ca2+AR). propionic acid 156-170 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 79-84 32810584-3 2020 Based on structural similarity, reactivity, physical-chemical properties, and expert judgment, propionic acid (CAS # 79-09-4) and isovaleric acid (CAS # 503-74-2) were identified as read-across analogs with sufficient data for toxicological evaluation. propionic acid 95-109 BCAR1 scaffold protein, Cas family member Homo sapiens 111-114 33279588-8 2021 Collectively, our findings reveal that juvenile social experience regulates prefrontal cortical OXTR expression through gut microbiota-produced PA and that is essential for normal social and emotional behaviors, thus providing a cellular and molecular context to understand the consequences of juvenile social deprivation. propionic acid 144-146 oxytocin receptor Mus musculus 96-100 32472357-2 2020 Ambrisentan is an oral, propanoic acid based-endothelin receptor antagonist (ERA), selective for the endothelin type-A receptor, which is approved for the treatment of PAH. propionic acid 24-38 estrogen receptor 1 Homo sapiens 39-75 32856645-9 2020 An increase in total short-chain fatty acids (SCFAs), propionic acid and butyric acid, was also observed by FOS supplementation. propionic acid 54-68 FBJ osteosarcoma oncogene Mus musculus 108-111 32997697-2 2020 GPR43 functioning involves the suppression of lipid accumulation and maintaining body energy homeostasis, and is activated by acetic acid or propionic acid. propionic acid 141-155 free fatty acid receptor 2 Homo sapiens 0-5 32487196-0 2020 Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux. propionic acid 0-14 mitogen-activated protein kinase 1 Homo sapiens 52-55 33041816-0 2020 Propionic Acid Targets the TLR4/NF-kappaB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies. propionic acid 0-14 toll-like receptor 4 Rattus norvegicus 27-31 33041816-5 2020 In vitro, we identified that PA treatment could strongly promote cell migration, inhibit activation of NLRP3 inflammasome and maintain intestinal barrier function in LPS-induced IEC-6 cells, indicating the protective effect on the intestinal barrier function of PA. propionic acid 29-31 NLR family, pyrin domain containing 3 Rattus norvegicus 103-108 33041816-6 2020 Further investigation of the mechanism involved revealed that PA could suppress the activation of TLR4/NF-kappaB pathway. propionic acid 62-64 toll-like receptor 4 Rattus norvegicus 98-102 32472598-0 2020 Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr-/- .Leiden mice. propionic acid 0-14 low density lipoprotein receptor Mus musculus 128-132 32414235-1 2020 We study the properties of acetic acid and propionic acid solutions at the surface of monocrystalline ice with surface-specific vibrational sum-frequency generation (VSFG) and heterodyne-detected vibrational sum-frequency generation spectroscopy (HD-VSFG). propionic acid 43-57 carboxylesterase 2 Homo sapiens 102-105 32487196-10 2020 Taken together, these results suggest a previously unknown link between PPA and autophagy in spine formation regulation in hippocampal neurons via MAPK/ERK signaling. propionic acid 72-75 mitogen-activated protein kinase 1 Homo sapiens 152-155 31683078-8 2020 On the other hand, propionic acid was the most abundant product at low temperatures and in the untreated anaerobic sludge (up to 60% in terms of COD). propionic acid 19-33 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 145-148 32481507-9 2020 Concerning protein expression propionic acid treatment increased STAT3 levels but did not lead to an increased phosphorylation indicative of pathway activation. propionic acid 30-44 signal transducer and activator of transcription 3 Homo sapiens 65-70 33312719-9 2020 While PPA induced significant increases in lipid peroxides and 5-lipoxygenase, together with significantly decreased glutathione, and cyclooxygenase 2, oral supplementation with Novavit ameliorated PPA-induced oxidative stress and impaired fatty acid metabolism. propionic acid 6-9 arachidonate 5-lipoxygenase Rattus norvegicus 63-77 31967697-7 2020 BDNF and CREB proteins are involved in both PRA neurotoxicity and treatment. propionic acid 44-47 brain-derived neurotrophic factor Rattus norvegicus 0-4 31967697-7 2020 BDNF and CREB proteins are involved in both PRA neurotoxicity and treatment. propionic acid 44-47 cAMP responsive element binding protein 1 Rattus norvegicus 9-13 32211767-0 2020 Chromium propionate increases insulin sensitivity in horses following oral and intravenous carbohydrate administration. propionic acid 0-19 INS Equus caballus 30-37 31267175-1 2019 In this work, a fed-batch approach was adopted to overcome propionic acid lipase inactivation effects in the benzyl propionate direct esterification mediated by lipases. propionic acid 59-73 PAN0_003d1715 Moesziomyces antarcticus 74-80 31512194-6 2019 We showed that the treatment of SAT with PA resulted in a significant downregulation of inflammatory parameters (e.g. TNF-alpha and IP-10) and macrophage markers (e.g. CD163 and MMP-9). propionic acid 41-43 tumor necrosis factor Homo sapiens 118-127 31512194-6 2019 We showed that the treatment of SAT with PA resulted in a significant downregulation of inflammatory parameters (e.g. TNF-alpha and IP-10) and macrophage markers (e.g. CD163 and MMP-9). propionic acid 41-43 C-X-C motif chemokine ligand 10 Homo sapiens 132-137 31512194-6 2019 We showed that the treatment of SAT with PA resulted in a significant downregulation of inflammatory parameters (e.g. TNF-alpha and IP-10) and macrophage markers (e.g. CD163 and MMP-9). propionic acid 41-43 CD163 molecule Homo sapiens 168-173 31512194-6 2019 We showed that the treatment of SAT with PA resulted in a significant downregulation of inflammatory parameters (e.g. TNF-alpha and IP-10) and macrophage markers (e.g. CD163 and MMP-9). propionic acid 41-43 matrix metallopeptidase 9 Homo sapiens 178-183 31512194-9 2019 PA significantly upregulated the expression of lipoprotein lipase (LPL), sterol regulatory-element-binding protein-1c (SREBP-1c) and glucose transporter 4 (GLUT-4), which are associated with lipogenesis and glucose uptake. propionic acid 0-2 lipoprotein lipase Homo sapiens 47-65 31512194-9 2019 PA significantly upregulated the expression of lipoprotein lipase (LPL), sterol regulatory-element-binding protein-1c (SREBP-1c) and glucose transporter 4 (GLUT-4), which are associated with lipogenesis and glucose uptake. propionic acid 0-2 lipoprotein lipase Homo sapiens 67-70 31512194-9 2019 PA significantly upregulated the expression of lipoprotein lipase (LPL), sterol regulatory-element-binding protein-1c (SREBP-1c) and glucose transporter 4 (GLUT-4), which are associated with lipogenesis and glucose uptake. propionic acid 0-2 sterol regulatory element binding transcription factor 1 Homo sapiens 73-117 31512194-9 2019 PA significantly upregulated the expression of lipoprotein lipase (LPL), sterol regulatory-element-binding protein-1c (SREBP-1c) and glucose transporter 4 (GLUT-4), which are associated with lipogenesis and glucose uptake. propionic acid 0-2 sterol regulatory element binding transcription factor 1 Homo sapiens 119-127 31512194-9 2019 PA significantly upregulated the expression of lipoprotein lipase (LPL), sterol regulatory-element-binding protein-1c (SREBP-1c) and glucose transporter 4 (GLUT-4), which are associated with lipogenesis and glucose uptake. propionic acid 0-2 solute carrier family 2 member 4 Homo sapiens 133-154 31512194-9 2019 PA significantly upregulated the expression of lipoprotein lipase (LPL), sterol regulatory-element-binding protein-1c (SREBP-1c) and glucose transporter 4 (GLUT-4), which are associated with lipogenesis and glucose uptake. propionic acid 0-2 solute carrier family 2 member 4 Homo sapiens 156-162 31733650-7 2019 The neurotoxic effects of PPA was clearly presented as much higher IL-6, as pro-inflammatory cytokine (P<0.05), concomitant with much lower IL-10, as anti-inflammatory cytokine(P<0.015) compared to controls. propionic acid 26-29 interleukin 6 Homo sapiens 67-71 31733650-7 2019 The neurotoxic effects of PPA was clearly presented as much higher IL-6, as pro-inflammatory cytokine (P<0.05), concomitant with much lower IL-10, as anti-inflammatory cytokine(P<0.015) compared to controls. propionic acid 26-29 interleukin 10 Homo sapiens 143-148 31733650-8 2019 Both bee pollen and propolis were effective in ameliorating the neurotoxic effects of PPA demonstrating non-significant changes of IL-6 and IL-10 when compared to control healthy hamsters. propionic acid 86-89 interleukin 6 Homo sapiens 131-135 31733650-8 2019 Both bee pollen and propolis were effective in ameliorating the neurotoxic effects of PPA demonstrating non-significant changes of IL-6 and IL-10 when compared to control healthy hamsters. propionic acid 86-89 interleukin 10 Homo sapiens 140-145 31526819-6 2019 The expression of the mitochondrial biogenesis-related proteins PGC-1alpha, TFAM, SIRT3, and COX4 was significantly increased after PPA treatment. propionic acid 132-135 PPARG coactivator 1 alpha Homo sapiens 64-74 31526819-6 2019 The expression of the mitochondrial biogenesis-related proteins PGC-1alpha, TFAM, SIRT3, and COX4 was significantly increased after PPA treatment. propionic acid 132-135 transcription factor A, mitochondrial Homo sapiens 76-80 31526819-6 2019 The expression of the mitochondrial biogenesis-related proteins PGC-1alpha, TFAM, SIRT3, and COX4 was significantly increased after PPA treatment. propionic acid 132-135 sirtuin 3 Homo sapiens 82-87 31526819-6 2019 The expression of the mitochondrial biogenesis-related proteins PGC-1alpha, TFAM, SIRT3, and COX4 was significantly increased after PPA treatment. propionic acid 132-135 cytochrome c oxidase subunit 4I1 Homo sapiens 93-97 31526819-7 2019 Transcriptome analysis revealed that mRNA expression in the notch signaling-related genes ASCL1 and LFNG changed after PPA treatment and the positive correlated protein expression changes were also observed. propionic acid 119-122 achaete-scute family bHLH transcription factor 1 Homo sapiens 90-95 31526819-7 2019 Transcriptome analysis revealed that mRNA expression in the notch signaling-related genes ASCL1 and LFNG changed after PPA treatment and the positive correlated protein expression changes were also observed. propionic acid 119-122 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Homo sapiens 100-104 31267175-6 2019 A novel qualitative protein content analysis by optical microscopy showed that the lipase was desorbed from the support after the esterification, and this behavior was strongly related to the presence of propionic acid in the reaction medium. propionic acid 204-218 PAN0_003d1715 Moesziomyces antarcticus 83-89 30521932-10 2019 In adulthood, the rats were again injected with PPA or the vehicle and tested on the light-dark and acoustic startle tasks on P74 and P77. propionic acid 48-51 spermatid perinuclear RNA binding protein Rattus norvegicus 126-129 31348919-0 2019 A selective peroxisome proliferator-activated receptor-gamma agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress. propionic acid 79-93 peroxisome proliferator-activated receptor gamma Rattus norvegicus 12-60 31348919-6 2019 This research evaluates the utility of selective agonist of PPAR-gamma, pioglitazone in postnatal propionic acid induced ASD related symptomatology in male Wistar rats. propionic acid 98-112 peroxisome proliferator-activated receptor gamma Rattus norvegicus 60-70 31348919-10 2019 Also, postnatal propionic acid-treated rats showed higher levels of oxidative stress (increased in thiobarbituric acid reactive species and decreased in reduced glutathione) as well as inflammation (increased in interleukin-6, tumor necrosis factor-alpha and decreased in interleukin-10) in the cerebellum, brainstem and prefrontal cortex. propionic acid 16-30 interleukin 6 Rattus norvegicus 212-254 31348919-10 2019 Also, postnatal propionic acid-treated rats showed higher levels of oxidative stress (increased in thiobarbituric acid reactive species and decreased in reduced glutathione) as well as inflammation (increased in interleukin-6, tumor necrosis factor-alpha and decreased in interleukin-10) in the cerebellum, brainstem and prefrontal cortex. propionic acid 16-30 interleukin 10 Rattus norvegicus 272-286 31217543-0 2019 Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder. propionic acid 0-14 phosphatase and tensin homolog Homo sapiens 76-80 31217543-0 2019 Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder. propionic acid 0-14 AKT serine/threonine kinase 1 Homo sapiens 81-84 31217543-8 2019 Following 2 mM PPA exposure, TNF-alpha transcription increased 4.98 fold and the cytokine increased 3.29 fold compared to control (P < 0.001). propionic acid 15-18 tumor necrosis factor Homo sapiens 29-38 31217543-10 2019 PTEN (Akt inhibitor) level decreased to (0.42 ug/ul +- 0.04 ug/ul) at 2 mM PPA compared to (0.83 ug/ul +- 0.09 ug/ul) in control (p < 0.001). propionic acid 75-78 phosphatase and tensin homolog Homo sapiens 0-4 31217543-10 2019 PTEN (Akt inhibitor) level decreased to (0.42 ug/ul +- 0.04 ug/ul) at 2 mM PPA compared to (0.83 ug/ul +- 0.09 ug/ul) in control (p < 0.001). propionic acid 75-78 AKT serine/threonine kinase 1 Homo sapiens 6-9 31044010-0 2019 Evolutionary engineering in Saccharomyces cerevisiae reveals a TRK1-dependent potassium influx mechanism for propionic acid tolerance. propionic acid 109-123 Trk1p Saccharomyces cerevisiae S288C 63-67 31044010-5 2019 Through whole genome sequencing and CRISPR-Cas9-mediated reverse engineering, unique mutations in TRK1, which encodes a high-affinity potassium transporter, were revealed as the cause of increased propionic acid tolerance. propionic acid 197-211 Trk1p Saccharomyces cerevisiae S288C 98-102 31044010-6 2019 Potassium supplementation growth assays showed that mutated TRK1 alleles and extracellular potassium supplementation not only conferred tolerance to PA stress but also to multiple organic acids. propionic acid 149-151 Trk1p Saccharomyces cerevisiae S288C 60-64 31019970-1 2019 This study aims to evaluate whether diets containing mixture of formic and propionic acid alone or supplemented with either capric acid or Bacillus Licheniformis can alleviate immune inflammatory response of piglets challenged with enterotoxigenic Escherichia coli (ETEC). propionic acid 75-89 ETEC Sus scrofa 266-270 30408471-8 2019 In adulthood, the rats were again injected with PPA or its vehicle on P74 and P77, and subsequently tested on the light-dark apparatus and acoustic startle task, respectively. propionic acid 48-51 spermatid perinuclear RNA binding protein Rattus norvegicus 70-73 30366038-1 2018 AIMS: The present study investigated the neuropharmacological role of PPAR-alpha modulator, fenofibrate in postnatal-propionic acid induced symptomatology related with autism spectrum disorders (ASD) in Wistar rats. propionic acid 117-131 peroxisome proliferator activated receptor alpha Rattus norvegicus 70-80 30881618-3 2019 In a nine-step synthesis starting from commercially available propionic acid 9 the thiophene derivative 7a was obtained as a bioisostere of the potent GluN2B ligands cis-3 and trans-3. propionic acid 62-76 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 151-157 30881618-3 2019 In a nine-step synthesis starting from commercially available propionic acid 9 the thiophene derivative 7a was obtained as a bioisostere of the potent GluN2B ligands cis-3 and trans-3. propionic acid 62-76 suppressor of cytokine signaling 3 Homo sapiens 166-171 30487423-4 2018 NQ-DCP was prepared by conjugating dicyanoisophorone fluoroprobe with hNQO1 activatable quinone propionic acid (QPA), which remain non-fluorescent until activation by tumor-specific hNQO1. propionic acid 96-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-75 30366038-11 2018 SIGNIFICANCE: A selective PPAR-alpha agonist, fenofibrate provides neurobehavioral and neurobiochemical benefits in postnatal-propionic acid induced autism-related phenotype in rats. propionic acid 126-140 peroxisome proliferator activated receptor alpha Rattus norvegicus 26-36 30487423-4 2018 NQ-DCP was prepared by conjugating dicyanoisophorone fluoroprobe with hNQO1 activatable quinone propionic acid (QPA), which remain non-fluorescent until activation by tumor-specific hNQO1. propionic acid 96-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 182-187 30284229-12 2018 The PPA-treated autistic model expressed significantly higher levels of lipid peroxides and 5-lipoxygenase (5-LOX) and significantly less glutathione (GSH), glutathione S-transferase (GST), and cyclooxygenase 2 (COX2) than the control group. propionic acid 4-7 arachidonate 5-lipoxygenase Rattus norvegicus 92-106 30284229-12 2018 The PPA-treated autistic model expressed significantly higher levels of lipid peroxides and 5-lipoxygenase (5-LOX) and significantly less glutathione (GSH), glutathione S-transferase (GST), and cyclooxygenase 2 (COX2) than the control group. propionic acid 4-7 arachidonate 5-lipoxygenase Rattus norvegicus 108-113 30284229-12 2018 The PPA-treated autistic model expressed significantly higher levels of lipid peroxides and 5-lipoxygenase (5-LOX) and significantly less glutathione (GSH), glutathione S-transferase (GST), and cyclooxygenase 2 (COX2) than the control group. propionic acid 4-7 hematopoietic prostaglandin D synthase Rattus norvegicus 157-182 30284229-12 2018 The PPA-treated autistic model expressed significantly higher levels of lipid peroxides and 5-lipoxygenase (5-LOX) and significantly less glutathione (GSH), glutathione S-transferase (GST), and cyclooxygenase 2 (COX2) than the control group. propionic acid 4-7 hematopoietic prostaglandin D synthase Rattus norvegicus 184-187 30284229-12 2018 The PPA-treated autistic model expressed significantly higher levels of lipid peroxides and 5-lipoxygenase (5-LOX) and significantly less glutathione (GSH), glutathione S-transferase (GST), and cyclooxygenase 2 (COX2) than the control group. propionic acid 4-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 194-210 30284229-12 2018 The PPA-treated autistic model expressed significantly higher levels of lipid peroxides and 5-lipoxygenase (5-LOX) and significantly less glutathione (GSH), glutathione S-transferase (GST), and cyclooxygenase 2 (COX2) than the control group. propionic acid 4-7 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 212-216 28321784-4 2017 Increasing the CG concentration repressed hydrogen production in favor of propionic acid, with a maximum yield of 6.19 mmol HPr g COD-1 at the CW/CG ratio of 5:3. propionic acid 74-88 haptoglobin-related protein Homo sapiens 124-127 30123322-11 2018 The analysis also suggests that a mutation in the cytochrome C biogenesis gene, coupled with ATP production through the Wood-Werkman cycle, may be responsible for the increased PA production. propionic acid 177-179 cytochrome c, somatic Homo sapiens 50-62 29431874-9 2018 Acetic acid, propionic acid, butyric acid and valeric acid significantly induced t-PA expression from two- to tenfolds. propionic acid 13-27 chromosome 20 open reading frame 181 Homo sapiens 81-85 29431874-10 2018 The strongest inducer of t-PA from NHBE cells was propionic acid; cells stimulated with propionic acid released t-PA into the supernatant in its active form. propionic acid 50-64 chromosome 20 open reading frame 181 Homo sapiens 25-29 29758151-12 2018 A number of discrete spectral changes were consistently observed with SnF2 dentifrice intervention, most notably including reductions in propionic acid and butyric acid, key short chain fatty acids associated with anaerobic metabolism in dental plaques. propionic acid 137-151 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 70-74 29167919-0 2018 Propionibacterium spp.-source of propionic acid, vitamin B12, and other metabolites important for the industry. propionic acid 33-47 histocompatibility minor 13 Homo sapiens 18-21 28946204-3 2017 The results demonstrated that the maximum organic loading rate (OLR) of the reactor was 2.5g propionic acid (HPr) L-1d-1 with approximately 1.20LL-1d-1 of volumetric methane production (VMP). propionic acid 93-107 haptoglobin-related protein Homo sapiens 109-112 29644593-1 2018 This study evaluated the propionic acid (HPr) production from crude glycerol (CG) (5000 mg L-1) in an anaerobic fluidized bed reactor (AFBR). propionic acid 25-39 haptoglobin-related protein Homo sapiens 41-44 30170600-0 2018 Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits. propionic acid 162-165 phospholipase A2 group IB Rattus norvegicus 106-122 30170600-11 2018 RESULTS: A significant decrease in phospholipid levels and a significant increase in cPLA2 were found in brain tissue of PPA-treated rats; however, both omega-3 and vitamin B12 were efficient in ameliorating the neurotoxic effect of PPA. propionic acid 121-124 phospholipase A2 group IVA Rattus norvegicus 85-90 29431874-10 2018 The strongest inducer of t-PA from NHBE cells was propionic acid; cells stimulated with propionic acid released t-PA into the supernatant in its active form. propionic acid 88-102 chromosome 20 open reading frame 181 Homo sapiens 25-29 29431874-10 2018 The strongest inducer of t-PA from NHBE cells was propionic acid; cells stimulated with propionic acid released t-PA into the supernatant in its active form. propionic acid 88-102 chromosome 20 open reading frame 181 Homo sapiens 112-116 29161570-3 2018 The results demonstrated that after long term of acclimation to low pH, the digester could produce methane from propionate at pH 4.8-5.5 with 0.3-0.4 L g-1 propionic acid (HPr) d-1 of the volatile solids (VS) methane production. propionic acid 156-170 haptoglobin-related protein Homo sapiens 172-175 28946479-1 2018 The present work highlights the effect of ultrasound on enzymatic synthesis of isobutyl propionate, a rum flavor by esterification of isobutanol and propionic acid in non-aqueous, solvent free system (SFS) using Fermase CALB 10000. propionic acid 149-163 calbindin 1 Homo sapiens 220-224 28321784-4 2017 Increasing the CG concentration repressed hydrogen production in favor of propionic acid, with a maximum yield of 6.19 mmol HPr g COD-1 at the CW/CG ratio of 5:3. propionic acid 74-88 component of oligomeric golgi complex 4 Homo sapiens 130-135 29079812-6 2017 Olfactory detection of propionic acid specifically is sufficient to trigger feeding behaviors, and this effect requires the correct activity of Or30a+ and Or94b+ olfactory sensory neurons. propionic acid 23-37 Odorant receptor 30a Drosophila melanogaster 144-149 29079812-6 2017 Olfactory detection of propionic acid specifically is sufficient to trigger feeding behaviors, and this effect requires the correct activity of Or30a+ and Or94b+ olfactory sensory neurons. propionic acid 23-37 Odorant receptor 94b Drosophila melanogaster 155-160 28977909-2 2017 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid (2-AAPA), an irreversible inhibitor of glutathione reductase (GR), is able to induce intracellular oxidative stress, and has shown anticancer activity in many cancer cell lines. propionic acid 95-111 glutathione-disulfide reductase Homo sapiens 151-172 29068997-2 2017 Cobalamin C (CblC) type is the most frequent inborn error of cobalamin metabolism; it can develop symptoms in childhood and often combine multisystem damage, which leads to methylmalonic acid, propionic acid, methyl citrate, and other metabolites abnormal accumulation, causing nerve, liver, kidney, bone marrow, and other organ damage. propionic acid 193-207 Cbl proto-oncogene C Homo sapiens 0-11 29068997-2 2017 Cobalamin C (CblC) type is the most frequent inborn error of cobalamin metabolism; it can develop symptoms in childhood and often combine multisystem damage, which leads to methylmalonic acid, propionic acid, methyl citrate, and other metabolites abnormal accumulation, causing nerve, liver, kidney, bone marrow, and other organ damage. propionic acid 193-207 Cbl proto-oncogene C Homo sapiens 13-17 28977909-2 2017 2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid (2-AAPA), an irreversible inhibitor of glutathione reductase (GR), is able to induce intracellular oxidative stress, and has shown anticancer activity in many cancer cell lines. propionic acid 95-111 glutathione-disulfide reductase Homo sapiens 174-176 28209214-15 2017 In summary, feeding a citrus pulp-based concentrate to lactating dairy cows consuming excessive energy did not improve insulin sensitivity, milk production and reproductive outcomes, whereas Cr-propionate supplementation only enhanced insulin sensitivity in cows receiving a corn-based concentrate during a GTT. propionic acid 191-204 insulin Bos taurus 235-242 28335773-5 2017 RESULTS: Our results suggested a higher concentration (23.5 +- 1.9 mmol/kg) of propionic acid compared to the physiological concentration (18.1 +- 0.9 mmol/kg) in colonic contents after oral administration increased the value of TER and the expression of ZO-1, Claudin-1, Claudin-8 and Occludin compared to the control group. propionic acid 79-93 tight junction protein 1 Rattus norvegicus 255-259 28335773-5 2017 RESULTS: Our results suggested a higher concentration (23.5 +- 1.9 mmol/kg) of propionic acid compared to the physiological concentration (18.1 +- 0.9 mmol/kg) in colonic contents after oral administration increased the value of TER and the expression of ZO-1, Claudin-1, Claudin-8 and Occludin compared to the control group. propionic acid 79-93 claudin 1 Rattus norvegicus 261-270 28335773-5 2017 RESULTS: Our results suggested a higher concentration (23.5 +- 1.9 mmol/kg) of propionic acid compared to the physiological concentration (18.1 +- 0.9 mmol/kg) in colonic contents after oral administration increased the value of TER and the expression of ZO-1, Claudin-1, Claudin-8 and Occludin compared to the control group. propionic acid 79-93 claudin 8 Rattus norvegicus 272-281 28335773-5 2017 RESULTS: Our results suggested a higher concentration (23.5 +- 1.9 mmol/kg) of propionic acid compared to the physiological concentration (18.1 +- 0.9 mmol/kg) in colonic contents after oral administration increased the value of TER and the expression of ZO-1, Claudin-1, Claudin-8 and Occludin compared to the control group. propionic acid 79-93 occludin Rattus norvegicus 286-294 28335773-6 2017 Furthermore, the expression levels of phosphorylated ERK1/2 and p38 MAPK were increased in propionic acid group. propionic acid 91-105 mitogen activated protein kinase 3 Rattus norvegicus 53-59 28335773-6 2017 Furthermore, the expression levels of phosphorylated ERK1/2 and p38 MAPK were increased in propionic acid group. propionic acid 91-105 mitogen activated protein kinase 14 Rattus norvegicus 64-67 28335773-7 2017 CONCLUSIONS: We concluded that continuous oral administration of propionic acid during lactation may increase its concentration in the proximal colon and promote epithelial barrier function of proximal colon by enhancing the expression of ZO-1, Claudin-8, Claudin-1 and Occludin via increases in the expression of ERK1/2 and p38 MAPK. propionic acid 65-79 tight junction protein 1 Rattus norvegicus 239-243 28335773-7 2017 CONCLUSIONS: We concluded that continuous oral administration of propionic acid during lactation may increase its concentration in the proximal colon and promote epithelial barrier function of proximal colon by enhancing the expression of ZO-1, Claudin-8, Claudin-1 and Occludin via increases in the expression of ERK1/2 and p38 MAPK. propionic acid 65-79 claudin 8 Rattus norvegicus 245-254 28335773-7 2017 CONCLUSIONS: We concluded that continuous oral administration of propionic acid during lactation may increase its concentration in the proximal colon and promote epithelial barrier function of proximal colon by enhancing the expression of ZO-1, Claudin-8, Claudin-1 and Occludin via increases in the expression of ERK1/2 and p38 MAPK. propionic acid 65-79 claudin 1 Rattus norvegicus 256-265 28335773-7 2017 CONCLUSIONS: We concluded that continuous oral administration of propionic acid during lactation may increase its concentration in the proximal colon and promote epithelial barrier function of proximal colon by enhancing the expression of ZO-1, Claudin-8, Claudin-1 and Occludin via increases in the expression of ERK1/2 and p38 MAPK. propionic acid 65-79 occludin Rattus norvegicus 270-278 28335773-7 2017 CONCLUSIONS: We concluded that continuous oral administration of propionic acid during lactation may increase its concentration in the proximal colon and promote epithelial barrier function of proximal colon by enhancing the expression of ZO-1, Claudin-8, Claudin-1 and Occludin via increases in the expression of ERK1/2 and p38 MAPK. propionic acid 65-79 mitogen activated protein kinase 3 Rattus norvegicus 314-320 28335773-7 2017 CONCLUSIONS: We concluded that continuous oral administration of propionic acid during lactation may increase its concentration in the proximal colon and promote epithelial barrier function of proximal colon by enhancing the expression of ZO-1, Claudin-8, Claudin-1 and Occludin via increases in the expression of ERK1/2 and p38 MAPK. propionic acid 65-79 mitogen activated protein kinase 14 Rattus norvegicus 325-328 28209214-11 2017 Serum insulin concentrations were less (P=0.04) in CRN supplemented with Cr-propionate compared with non-supplemented CRN (8.2 v. 13.5 microIU/ml, respectively; SEM=1.7), whereas Cr-propionate supplementation did not impact (P=0.70) serum insulin within PLP cows. propionic acid 73-86 insulin Bos taurus 6-13 28193246-3 2017 We have recently shown by patch clamping experiments and Western blots that acute and chronic effects of accumulating metabolites such as propionic acid, propionylcarnitine and methylcitrate on the KvLQT1/KCNE1 channel complex cause long QT syndrome in patients with propionic acidemia by inhibition of K+ flow via this channel. propionic acid 138-152 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 198-204 28003429-9 2017 These results suggested that ACSS3 is a liver mitochondrial matrix enzyme with high affinity to propionic acid, and its expression level is upregulated under ketogenic conditions. propionic acid 96-110 acyl-CoA synthetase short-chain family member 3 Rattus norvegicus 29-34 28193246-3 2017 We have recently shown by patch clamping experiments and Western blots that acute and chronic effects of accumulating metabolites such as propionic acid, propionylcarnitine and methylcitrate on the KvLQT1/KCNE1 channel complex cause long QT syndrome in patients with propionic acidemia by inhibition of K+ flow via this channel. propionic acid 138-152 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 205-210 27707757-7 2016 Moreover, three additional mitochondrial experiments showed mitochondrial membrane depolarization, calcium accumulation and cytochrome c release after cells were exposed to PPA, indicating that the PPA-induced apoptosis pathway is mediated by mitochondria. propionic acid 173-176 cytochrome c, somatic Homo sapiens 124-136 28161992-9 2017 The chemical analysis reveals ACE is full of triterpenes, the most abundant of which is Antcin K, followed by sulphurenic acid, eburicoic acid, antcin C, dehydrosulphurenic acid, antcin B, and propanoic acid. propionic acid 193-207 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus 30-33 27959364-1 2017 A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. propionic acid 14-28 2,4-dienoyl-CoA reductase 1 Homo sapiens 79-86 27959364-1 2017 A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. propionic acid 14-28 NAD(P)H quinone dehydrogenase 1 Homo sapiens 111-116 27880936-7 2016 Administration of proanthocyanidins increased the concentration of propionic acid and butyric acid in the ileum and colon, which may activate the expression of GPR41. propionic acid 67-81 free fatty acid receptor 3 Homo sapiens 160-165 27707757-7 2016 Moreover, three additional mitochondrial experiments showed mitochondrial membrane depolarization, calcium accumulation and cytochrome c release after cells were exposed to PPA, indicating that the PPA-induced apoptosis pathway is mediated by mitochondria. propionic acid 198-201 cytochrome c, somatic Homo sapiens 124-136 27107819-9 2016 RESULTS: The obtained data showed that the PA-treated groups demonstrated multiple signs of brain toxicity, as indicated by a depletion of serotonin (5HT), dopamine and nor-adrenaline, together withan increase in IFN-gamma and caspase 3. propionic acid 43-45 interferon gamma Rattus norvegicus 213-236 27942501-6 2016 Also glutamate, IL-6 levels were significantly (P<0.001) increased in PA treated group while non-significant increase was found in ampicillin treated group. propionic acid 73-75 interleukin 6 Rattus norvegicus 16-20 26854997-12 2016 Chronic exposure to 10 mM PA, in contrast, increased KCNQ1 5.4-fold (P < .001) owing to decreased protein degradation. propionic acid 26-28 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 53-58 27132595-1 2016 Methylmalonic acid (MMA) is a by-product of propionic acid metabolism through the vitamin B12 (cobalamin)-dependent enzyme methylmalonyl CoA mutase. propionic acid 44-58 methylmalonyl-CoA mutase Homo sapiens 123-147 26933236-0 2016 Chromium propionate in broilers: effect on insulin sensitivity. propionic acid 0-19 insulin Homo sapiens 43-50 26933236-1 2016 The objective of this study was to evaluate the effects of dietary chromium (Cr), as chromium propionate, on measures of insulin sensitivity. propionic acid 85-104 insulin Homo sapiens 121-128 26933236-13 2016 Results of this study indicate that Cr propionate supplementation of a control diet containing 0.43 to 0.45 mg Cr/kg enhanced insulin sensitivity. propionic acid 36-49 insulin Homo sapiens 126-133 25277114-1 2015 This paper reports on propionic acid (HPr) degradation in a laboratory scale two-phase anaerobic system, where HPr was accumulated in the acidogenic reactor and degraded in the methanogenic reactor. propionic acid 22-36 haptoglobin-related protein Homo sapiens 38-41 26492176-5 2016 The half-lives were in the order HAc<HBu<HPr showing a slower gas production from the C3 acid than from the C4 acid. propionic acid 92-99 haptoglobin-related protein Homo sapiens 47-50 26395755-7 2015 In differentiated myogenic-like C2C12 cells, propionic acid, but not acetic or n-butyric acids, directly enhanced UCP-1 expression by approximately 2-fold (P<0 01). propionic acid 45-59 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 114-119 26821575-12 2016 We experimentally validated that Oye2p from Saccharomyces cerevisiae can catalyze this reaction at a slow turnover rate (10(-3) s(-1) ), which was unknown to occur with this enzyme, and is an important finding for further propionic acid metabolic engineering. propionic acid 222-236 NADPH dehydrogenase Saccharomyces cerevisiae S288C 33-38 26395755-9 2015 It is suggested that propionic acid--a bacterial metabolite--acts as a mediator to induce UCP-1 expression in skeletal muscles. propionic acid 21-35 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 90-95 25277114-1 2015 This paper reports on propionic acid (HPr) degradation in a laboratory scale two-phase anaerobic system, where HPr was accumulated in the acidogenic reactor and degraded in the methanogenic reactor. propionic acid 22-36 haptoglobin-related protein Homo sapiens 111-114 25277114-5 2015 Results from pyrosequencing showed that the predominant propionic acid oxidizing bacteria (POB) in the methanogenic reactor were Smithella (2.68%) and Syntrophobacter (0.35%); while poor degradation of HPr in the acidogenic reactor may be associated with the low abundance of POB (0.02% Desulfacinum and 0.08% Desulfobulbus). propionic acid 56-70 haptoglobin-related protein Homo sapiens 202-205 25459845-7 2015 The calculated maintenance coefficient (mATP) increased 100%, which may explain the increase in the productivity of propionic acid in glycerol fermentation with CO2 supplement. propionic acid 116-130 solute carrier family 45, member 2 Mus musculus 40-44 26541062-10 2015 Propionic acid inhibited two out of two Penicillium spp. propionic acid 0-14 histocompatibility minor 13 Homo sapiens 52-55 26664955-5 2015 Enhancement of adenosine monophosphate-activated protein kinase and GLUT4 mRNA by CrPro treatment may enhance glucose uptake in IM adipocytes. propionic acid 82-87 solute carrier family 2 member 4 Bos taurus 68-73 26664955-6 2015 CrPro decreased GLUT4 protein levels in muscle cell cultures suggesting that those cells have increased efficiency of glucose uptake due to exposure to increased levels of CrPro. propionic acid 0-5 solute carrier family 2 member 4 Bos taurus 16-21 25965252-5 2015 For pH 4 and short retention time propionic acid was the major product instead of acetic acid. propionic acid 34-48 prolyl 4-hydroxylase, transmembrane Homo sapiens 4-8 25953702-7 2015 NSAIDs that are propionic acid (PA) derivatives and cause IDILI that is of less clinical concern also synergized with TNFalpha, but IFNgamma was without effect. propionic acid 16-30 tumor necrosis factor Homo sapiens 118-126 25953702-7 2015 NSAIDs that are propionic acid (PA) derivatives and cause IDILI that is of less clinical concern also synergized with TNFalpha, but IFNgamma was without effect. propionic acid 32-34 tumor necrosis factor Homo sapiens 118-126 25953702-9 2015 Treatment with a representative AA or PA derivative induced activation of the MAPKs c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38. propionic acid 38-40 mitogen-activated protein kinase 8 Homo sapiens 84-107 25953702-9 2015 Treatment with a representative AA or PA derivative induced activation of the MAPKs c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38. propionic acid 38-40 mitogen-activated protein kinase 8 Homo sapiens 109-112 25953702-9 2015 Treatment with a representative AA or PA derivative induced activation of the MAPKs c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38. propionic acid 38-40 mitogen-activated protein kinase 1 Homo sapiens 115-152 25953702-9 2015 Treatment with a representative AA or PA derivative induced activation of the MAPKs c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38. propionic acid 38-40 mitogen-activated protein kinase 1 Homo sapiens 154-157 25953702-9 2015 Treatment with a representative AA or PA derivative induced activation of the MAPKs c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38. propionic acid 38-40 mitogen-activated protein kinase 14 Homo sapiens 164-167 25953702-11 2015 In contrast, an ERK inhibitor potentiated cytotoxicity from cytokine interactions with PA derivatives. propionic acid 87-89 mitogen-activated protein kinase 1 Homo sapiens 16-19 26629488-9 2015 Biochemical analysis of liver homogenates from PA-treated rats showed an increase in oxidative stress markers like lipid peroxidation and lactate dehydrogenase, coupled with a decrease in glutathione, vitamin C and glutathione S- transferase. propionic acid 47-49 hematopoietic prostaglandin D synthase Rattus norvegicus 215-241 25475691-7 2015 The highest hop cone concentration significantly decreased acetic and butyric acid productions and total SCFA production after 24 h of incubation, but not propionic acid production, resulting in a decreased ratio between acetic acid and propionic acid. propionic acid 237-251 HOP homeobox Bos taurus 12-15 25790461-6 2015 Expression of the bovine FFAR1 receptor in Chinese hamster ovary (CHO)-K1 cells increased the levels of intracellular calcium induced by the LCFAs, oleic acid (OA) and linoleic acid (LA); no increase in calcium mobilization was observed in the presence of the short chain fatty acid propionic acid. propionic acid 283-297 free fatty acid receptor 1 Bos taurus 25-30 25461311-3 2015 Here, we utilized the helix12 (H12)-folding inhibition hypothesis, in combination with our previously determined X-ray crystal structure of PPARgamma agonist MEKT-21 (6) complexed with the PPARgamma ligand-binding domain, to design and develop a potent phenylalkynyl amide-type PPARgamma antagonist 9i, focusing initially on pinpoint structural modification of the propanoic acid moiety of 6. propionic acid 365-379 peroxisome proliferator activated receptor gamma Homo sapiens 140-149 25461311-3 2015 Here, we utilized the helix12 (H12)-folding inhibition hypothesis, in combination with our previously determined X-ray crystal structure of PPARgamma agonist MEKT-21 (6) complexed with the PPARgamma ligand-binding domain, to design and develop a potent phenylalkynyl amide-type PPARgamma antagonist 9i, focusing initially on pinpoint structural modification of the propanoic acid moiety of 6. propionic acid 365-379 peroxisome proliferator activated receptor gamma Homo sapiens 189-198 25461311-3 2015 Here, we utilized the helix12 (H12)-folding inhibition hypothesis, in combination with our previously determined X-ray crystal structure of PPARgamma agonist MEKT-21 (6) complexed with the PPARgamma ligand-binding domain, to design and develop a potent phenylalkynyl amide-type PPARgamma antagonist 9i, focusing initially on pinpoint structural modification of the propanoic acid moiety of 6. propionic acid 365-379 peroxisome proliferator activated receptor gamma Homo sapiens 189-198 26167409-3 2015 We show that both propionic acid and butyric acid inhibit isoproterenol- and adenosine deaminase-stimulated lipolysis as well as isoproterenol-stimulated lipolysis in the presence of a phosphodiesterase (PDE3) inhibitor. propionic acid 18-32 phosphodiesterase 4D, cAMP-specific-like 1 Rattus norvegicus 204-208 25234246-8 2014 In addition, Notch1cKOKln mice display reduced olfactory aversion to propionic acid as compared to wildtype controls. propionic acid 69-83 notch 1 Mus musculus 13-19 24798298-0 2014 The source of inoculum plays a defining role in the development of MEC microbial consortia fed with acetic and propionic acid mixtures. propionic acid 111-125 C-C motif chemokine ligand 28 Homo sapiens 67-70 25344727-12 2014 RESULTS: The obtained data showed that the PPA-treated group demonstrated higher plasma vitamin D levels compared to the control rats, together with multiple signs of brain toxicity, as indicated by a depletion of serotonin (5HT), an increase in IFN-gamma and inhibition of glutathione-s-transferase activity as three biomarkers of brain dysfunction. propionic acid 43-46 interferon gamma Rattus norvegicus 246-255 25344727-12 2014 RESULTS: The obtained data showed that the PPA-treated group demonstrated higher plasma vitamin D levels compared to the control rats, together with multiple signs of brain toxicity, as indicated by a depletion of serotonin (5HT), an increase in IFN-gamma and inhibition of glutathione-s-transferase activity as three biomarkers of brain dysfunction. propionic acid 43-46 hematopoietic prostaglandin D synthase Rattus norvegicus 274-299 28324386-2 2014 In this study, three compounds including propionic acid, lithium chloride and butyric acid were added to the medium which decreased acetate levels and enhanced recombinant protein production (alpha-synuclein). propionic acid 41-55 synuclein alpha Homo sapiens 192-207 25205257-1 2014 Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC). propionic acid 18-32 methylmalonyl-CoA mutase Homo sapiens 173-197 24748202-2 2014 Among the free fatty acid receptor (FFAR) family of G protein-coupled receptors, GPR41 is known to be the Galphai/o-coupled receptor for short-chain fatty acids (SCFAs) such as propionic acid (C3) and valeric acid (C5). propionic acid 177-191 free fatty acid receptor 3 Homo sapiens 81-86 24745737-8 2014 The use of 1 M propionic acid as elution agent provides higher than 40% recovery of high purity PSA. propionic acid 15-29 kallikrein related peptidase 3 Homo sapiens 96-99 25505590-7 2014 N-debutyl-dronedarone was less rapidly metabolized than dronedarone, the major metabolic pathway being catalyzed by MAO-A to form propanoic acid-dronedarone and phenol-dronedarone. propionic acid 130-144 monoamine oxidase A Homo sapiens 116-121 25505590-8 2014 Propanoic acid-dronedarone was metabolized at a similar rate to that of N-debutyl-dronedarone and was predominantly hydroxylated by CYP2C8 and CYP1A1. propionic acid 0-14 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 132-138 25505590-8 2014 Propanoic acid-dronedarone was metabolized at a similar rate to that of N-debutyl-dronedarone and was predominantly hydroxylated by CYP2C8 and CYP1A1. propionic acid 0-14 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24691985-2 2014 The ABC transporter Pdr12 is important for resistance to sorbic and propionic acid, but its role in tolerance to other weak organic acids with industrial relevance is not well established. propionic acid 68-82 ATP-binding cassette multidrug transporter PDR12 Saccharomyces cerevisiae S288C 20-25 24748202-7 2014 Both propionic acid and valeric acid increased insulin-stimulated glucose uptake in 3T3-L1 adipocyte, which did not occur in cells transfected with siRNA for GPR41 (siGPR41). propionic acid 5-19 insulin Homo sapiens 47-54 24305873-0 2014 Effects of excessive energy intake and supplementation with chromium propionate on insulin resistance parameters in nonlactating dairy cows. propionic acid 60-79 insulin Bos taurus 83-90 24305873-13 2014 In conclusion, chromium propionate supplementation prevented the increase in insulin resistance caused by excessive energy intake in nonlactating dairy cows. propionic acid 15-34 insulin Bos taurus 77-84 23645771-9 2013 Zaltoprofen is a propionic-acid derivative non-steroidal anti-inflammatory drug, and it is reported to act as a direct ligand for PPARgamma. propionic acid 17-31 peroxisome proliferator activated receptor gamma Homo sapiens 130-139 23814018-6 2013 However, the nuclear receptor peroxisome proliferator activated receptor alpha (PPARalpha), which regulates fatty acid oxidation, was also increased by DEX, and adipocyte-derived lipids, lipoproteins, and propionic acid protected CLL cells from DEX. propionic acid 205-219 peroxisome proliferator activated receptor alpha Homo sapiens 80-89 21913915-8 2012 RESULTS: Treatment of adipose tissue explants with propionic acid results in a significant down-regulation of several inflammatory cytokines and chemokines such as TNF-alpha and CCL5. propionic acid 51-65 tumor necrosis factor Homo sapiens 164-173 23373464-2 2013 The present work accounts for the acidity determination of HCOOH, CH3COOH, and CH3CH2COOH in the alkylimidazolium-based protic ionic liquids (PILs), incorporated with carboxylate anion, water, and in a binary mixture of PIL and water using the Hammett acidity function, H0. propionic acid 79-89 serpin family A member 2 (gene/pseudogene) Homo sapiens 142-145 23537042-9 2013 RESULTS: The obtained data showed that PPA caused multiple signs of brain toxicity as measured by depletion of serotonin (5HT), increase in IFN-gamma and inhibition of glutathione-s-transferase activity as three biomarkers of brain dysfunction. propionic acid 39-42 interferon gamma Rattus norvegicus 140-149 23787314-5 2013 Acetic acid was a predominant VFA in sewage, and the propionic acid (HPr) portion averaged 38.7% of total VFACOD. propionic acid 53-67 haptoglobin-related protein Homo sapiens 69-72 22531301-9 2012 Elevated IL-6, TNFalpha, IFNgamma and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. propionic acid 110-112 interleukin 6 Rattus norvegicus 9-13 22531301-9 2012 Elevated IL-6, TNFalpha, IFNgamma and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. propionic acid 110-112 tumor necrosis factor Rattus norvegicus 15-23 22531301-9 2012 Elevated IL-6, TNFalpha, IFNgamma and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. propionic acid 110-112 interleukin 18 Rattus norvegicus 25-33 22531301-9 2012 Elevated IL-6, TNFalpha, IFNgamma and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. propionic acid 110-112 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 38-59 22531301-9 2012 Elevated IL-6, TNFalpha, IFNgamma and heat shock protein 70 (HSP70) confirmed the neuroinflammatory effect of PA. propionic acid 110-112 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 61-66 22531301-10 2012 Moreover, elevation of caspase3 and DNA fragmentation proved the pro-apoptotic and neurotoxic effect of PA to rat pups CONCLUSION: By comparing the results obtained with those from animal models of autism or with clinical data on the biochemical profile of autistic patients, this study showed that the neurotoxicity of PA as an environmental factor could play a central role in the etiology of autistic biochemical features. propionic acid 104-106 caspase 3 Rattus norvegicus 23-31 21913915-8 2012 RESULTS: Treatment of adipose tissue explants with propionic acid results in a significant down-regulation of several inflammatory cytokines and chemokines such as TNF-alpha and CCL5. propionic acid 51-65 C-C motif chemokine ligand 5 Homo sapiens 178-182 21927746-1 2011 A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors. propionic acid 14-28 NAD(P)H quinone dehydrogenase 1 Homo sapiens 127-159 22459849-0 2012 Chromium propionate enhances insulin sensitivity in growing cattle. propionic acid 0-19 insulin Bos taurus 29-36 21927746-1 2011 A new quinone propionic acid-cloaked rhodamine fluorophore has its fluorescence revealed (de-cloaked) upon activation by human NAD(P)H:quinone oxidoreductase 1 (hNQO1), an upregulated enzyme in cancer cells and tumors. propionic acid 14-28 NAD(P)H quinone dehydrogenase 1 Homo sapiens 161-166 21570838-0 2011 Structure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. propionic acid 118-132 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 50-80 21484805-9 2011 The dEAAT2 mutant showed decreased avoidance behavior in the presence of high concentration of propionic acid compared with wild-type flies, but no modification of the avoidance response to benzaldehyde. propionic acid 95-109 Excitatory amino acid transporter 2 Drosophila melanogaster 4-10 21854591-11 2011 CONCLUSIONS: Omega-3 fatty acids showed a protective effects on PPA - induced changes in rats as there was a remarkable amelioration of most of the measured parameters (i.e. higher GABA, 5HT, DA, PE, PS and PC) and lower Il-6, TNF-alpha and caspase-3. propionic acid 64-67 tumor necrosis factor Rattus norvegicus 227-236 21854591-11 2011 CONCLUSIONS: Omega-3 fatty acids showed a protective effects on PPA - induced changes in rats as there was a remarkable amelioration of most of the measured parameters (i.e. higher GABA, 5HT, DA, PE, PS and PC) and lower Il-6, TNF-alpha and caspase-3. propionic acid 64-67 caspase 3 Rattus norvegicus 241-250 20691280-6 2010 The molecular mechanisms by which PA may exert this plethora of physiological effects are slowly being elucidated and include intestinal cyclooxygenase enzyme, the G-protein coupled receptors 41 and 43 and activation of the peroxisome proliferator-activated receptor gamma, in turn inhibiting the sentinel transcription factor NF-kappaB and thus increasing the threshold for inflammatory responses in general. propionic acid 34-36 peroxisome proliferator activated receptor gamma Homo sapiens 224-272 21167025-1 2010 BACKGROUND: SHANK3 is a protein in the core of the postsynaptic density (PSD) and has a critical role in recruiting many key functional elements to the PSD and to the synapse, including components of alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA), metabotropic glutamate (mGlu) and N-methyl-D-aspartic acid (NMDA) glutamate receptors, as well as cytoskeletal elements. propionic acid 244-258 SH3 and multiple ankyrin repeat domains 3 Mus musculus 12-18 20691280-6 2010 The molecular mechanisms by which PA may exert this plethora of physiological effects are slowly being elucidated and include intestinal cyclooxygenase enzyme, the G-protein coupled receptors 41 and 43 and activation of the peroxisome proliferator-activated receptor gamma, in turn inhibiting the sentinel transcription factor NF-kappaB and thus increasing the threshold for inflammatory responses in general. propionic acid 34-36 nuclear factor kappa B subunit 1 Homo sapiens 327-336 20435078-0 2010 Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro. propionic acid 39-53 negative elongation factor complex member C/D Homo sapiens 85-88 20435078-1 2010 Food preservatives sodium benzoate and propionic acid and colorant curcumin are demonstrated to suppress in a dose-dependent manner Th1-type immune response in human peripheral blood mononuclear cells (PBMC) in vitro. propionic acid 39-53 negative elongation factor complex member C/D Homo sapiens 132-135 20229566-1 2010 Herein, we examine the potential of a nitrile-containing propionic acid moiety as an electrophile for covalent attack by the active-site cysteine residue of caspase 1. propionic acid 57-71 caspase 1 Homo sapiens 157-166 20202839-1 2010 A new group of acetic acid (7a-c, R(1) = H), and propionic acid (7d-f, R(1) = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is attached via its C-3, C-4, and C-5 position was synthesized. propionic acid 49-63 complement C3 Homo sapiens 173-176 20353437-4 2010 As PA has been shown to be a ligand for G-protein coupled receptor (GPCR) 41 and 43, we investigated the role of GPCR"s in PA signalling. propionic acid 3-5 C-X-C motif chemokine receptor 6 Homo sapiens 40-66 20353437-4 2010 As PA has been shown to be a ligand for G-protein coupled receptor (GPCR) 41 and 43, we investigated the role of GPCR"s in PA signalling. propionic acid 3-5 C-X-C motif chemokine receptor 6 Homo sapiens 68-72 20202839-1 2010 A new group of acetic acid (7a-c, R(1) = H), and propionic acid (7d-f, R(1) = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is attached via its C-3, C-4, and C-5 position was synthesized. propionic acid 49-63 complement C4A (Rodgers blood group) Homo sapiens 178-181 20202839-1 2010 A new group of acetic acid (7a-c, R(1) = H), and propionic acid (7d-f, R(1) = Me), regioisomers wherein a N-difluoromethyl-1,2-dihydropyrid-2-one moiety is attached via its C-3, C-4, and C-5 position was synthesized. propionic acid 49-63 complement C5 Homo sapiens 187-190 20202839-3 2010 Attachment of the N-difluoromethyl-1,2-dihydropyrid-2-one ring system to an acetic acid, or propionic acid, moiety confers potent 5-LOX inhibitory activity, that is, absent in traditional arylacetic acid NSAIDs. propionic acid 92-106 lysyl oxidase Homo sapiens 132-135 20087867-7 2010 Finally, post-column infusion of propionic acid and acetic acid was evaluated for their potential to recover signal intensity for TFA and MSA counter-ions for LC-ESI-MS applications. propionic acid 33-47 coagulation factor III, tissue factor Homo sapiens 130-133 19553547-0 2009 Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells. propionic acid 0-14 killer cell lectin like receptor K1 Homo sapiens 54-59 19718436-5 2009 The rate of the indicated rise of [Na(+)](i) is greater for sperm alkalinized with NH(4)Cl than for sperm acidified with propionic acid, reflecting the alkaline-promoted signature property of CatSper currents. propionic acid 121-135 cation channel sperm associated 1 Homo sapiens 192-199 19773541-6 2009 Subsequent experiments identified that, in addition to SDCIT, the propionic acid metabolite of SCIT (SCIT PROP) was formed by CYP2C19 in vitro. propionic acid 66-80 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 126-133 19553547-1 2009 We found that propionic acid secreted from propionibacteria induces expression of the NKG2D ligands MICA/B on activated T lymphocytes and different cancer cells, without affecting MICA/B expression on resting peripheral blood cells. propionic acid 14-28 killer cell lectin like receptor K1 Homo sapiens 86-91 19553547-1 2009 We found that propionic acid secreted from propionibacteria induces expression of the NKG2D ligands MICA/B on activated T lymphocytes and different cancer cells, without affecting MICA/B expression on resting peripheral blood cells. propionic acid 14-28 MHC class I polypeptide-related sequence A Homo sapiens 100-104 19464879-1 2009 INTRODUCTION: XK469 is a novel topoisomerase II inhibitor structurally akin to several propionic acid derivatives, such as ibuprofen and diclofenac, which are metabolised by CYP2C9. propionic acid 87-101 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 174-180 19397999-3 2009 In this study, an increase in GSSG was effectively created using 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid (2-AAPA), an irreversible glutathione reductase (GR) inhibitor. propionic acid 166-181 glutathione-disulfide reductase Homo sapiens 208-229 19397999-3 2009 In this study, an increase in GSSG was effectively created using 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid (2-AAPA), an irreversible glutathione reductase (GR) inhibitor. propionic acid 166-181 glutathione-disulfide reductase Homo sapiens 231-233 19342228-1 2009 The maximum propionic acid (HPr) removal rate (R(HPr)) was investigated in two lab-scale Upflow Anaerobic Sludge Bed (UASB) reactors. propionic acid 12-26 haptoglobin-related protein Homo sapiens 28-31 19201188-0 2009 Study on solvent extraction of propionic acid from simulated discharged water in vitamin B12 production by anaerobic fermentation. propionic acid 31-45 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 89-92 19515396-1 2009 Full-scale anaerobic single-phase digesters can be confronted with process instabilities, which often result in the accumulation of propionic acid (HPr). propionic acid 132-146 haptoglobin-related protein Homo sapiens 148-151 19220866-0 2009 The RIM101 pathway has a role in Saccharomyces cerevisiae adaptive response and resistance to propionic acid and other weak acids. propionic acid 94-108 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 4-10 19220866-3 2009 The Rim101p-dependent alterations of the yeast transcriptome following exposure to propionic acid stress (at pH 4.0) include genes of the previously described Rim101p regulon but also new target genes, in particular KNH1, involved in cell wall beta-1,6-glucan synthesis and the uncharacterized ORF YIL029c, both required for maximal propionic acid resistance. propionic acid 83-97 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 4-11 19220866-3 2009 The Rim101p-dependent alterations of the yeast transcriptome following exposure to propionic acid stress (at pH 4.0) include genes of the previously described Rim101p regulon but also new target genes, in particular KNH1, involved in cell wall beta-1,6-glucan synthesis and the uncharacterized ORF YIL029c, both required for maximal propionic acid resistance. propionic acid 83-97 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 159-166 19220866-3 2009 The Rim101p-dependent alterations of the yeast transcriptome following exposure to propionic acid stress (at pH 4.0) include genes of the previously described Rim101p regulon but also new target genes, in particular KNH1, involved in cell wall beta-1,6-glucan synthesis and the uncharacterized ORF YIL029c, both required for maximal propionic acid resistance. propionic acid 333-347 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 4-11 19220866-5 2009 The analysis of the network of interactions established among all the identified propionic acid resistance determinants shows an enrichment of interactions around the RIM101 gene and highlights the role of proteins involved in Rim101p proteolytic processing. propionic acid 81-95 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 167-173 19220866-5 2009 The analysis of the network of interactions established among all the identified propionic acid resistance determinants shows an enrichment of interactions around the RIM101 gene and highlights the role of proteins involved in Rim101p proteolytic processing. propionic acid 81-95 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 227-234 19220866-6 2009 RIM101 expression is shown to be required to counteract propionic acid-induced cytosolic acidification and for proper vacuolar acidification and cell wall structure, these having positive implications for a robust adaptive response and resistance to stress promoted by this food preservative. propionic acid 56-70 alkaline-responsive transcriptional regulator RIM101 Saccharomyces cerevisiae S288C 0-6 18452327-3 2008 The nuC=O frequencies and their shifts upon OH deuteration were calculated for model complexes of acetic acid and propionic acid H bonded at different sites with various compounds. propionic acid 114-128 nucleobindin 1 Homo sapiens 4-7 17662338-3 2007 It was observed that with pH increasing from 6.4 to 8.0, the anaerobic propionic acid uptake rate by PAO linearly increased but that by GAO proportionally decreased. propionic acid 71-85 spermine oxidase Homo sapiens 101-104 17662338-4 2007 At pH 6.70 and pH 7.51, PAO and GAO exhibited the same acetic and propionic acid uptake rates, respectively. propionic acid 66-80 spermine oxidase Homo sapiens 24-27 17662338-5 2007 The acetic acid uptake rate by PAO was greater than that by GAO at pH>6.70, and the propionic acid uptake rate by PAO was higher than that by GAO at pH>7.51, which indicated that PAO would take predominance over GAO at pH>7.51. propionic acid 87-101 spermine oxidase Homo sapiens 117-120 17662338-5 2007 The acetic acid uptake rate by PAO was greater than that by GAO at pH>6.70, and the propionic acid uptake rate by PAO was higher than that by GAO at pH>7.51, which indicated that PAO would take predominance over GAO at pH>7.51. propionic acid 87-101 spermine oxidase Homo sapiens 117-120 17553913-6 2007 The estimated K(i) values for the inhibition of TPMT by ketoprofen (K(i) = 172 microM) and ibuprofen (K(i) = 1043 microM) indicated that the propionic acid derivatives were relatively weak inhibitors of TPMT. propionic acid 141-155 thiopurine S-methyltransferase Homo sapiens 48-52 17553913-6 2007 The estimated K(i) values for the inhibition of TPMT by ketoprofen (K(i) = 172 microM) and ibuprofen (K(i) = 1043 microM) indicated that the propionic acid derivatives were relatively weak inhibitors of TPMT. propionic acid 141-155 thiopurine S-methyltransferase Homo sapiens 203-207 17763989-1 2007 An immunohistochemical method was used to study the expression of transcription factor c-Fos in the mid part of the main olfactory bulbs in 18-day-old rats after training to seek their mothers using an olfactory orientation cue (propionic acid) in a Y-maze. propionic acid 229-243 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 87-92 17763989-3 2007 The propionic acid odor evoked an insignificant increase in c-Fos expression, predominantly in the granular layer of the dorsomedial area of the olfactory bulb. propionic acid 4-18 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 60-65 17599908-7 2007 Orysa;EL2 mRNA levels were induced by cold, drought, and propionic acid. propionic acid 57-71 epilepsy 2 Mus musculus 6-9 17147208-3 2006 Exposure to propionic acid produced a moderate activation of c-Fos expression, mainly in the granular layer of the dorsomedial part of the bulb. propionic acid 12-26 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 61-66 17603200-2 2007 In PPAR binding affinity assays, compound 4, which had an ethoxy group at the C-2 position of the propanoic acid of 1, showed selective binding affinity for PPARgamma. propionic acid 98-112 peroxisome proliferator activated receptor alpha Homo sapiens 3-7 17603200-2 2007 In PPAR binding affinity assays, compound 4, which had an ethoxy group at the C-2 position of the propanoic acid of 1, showed selective binding affinity for PPARgamma. propionic acid 98-112 peroxisome proliferator activated receptor gamma Homo sapiens 157-166 17603200-5 2007 The introduction of methyl (7) and ethyl (8) groups to the C-2 position of the propanoic acid of 6 further improved PPARalpha-binding potency. propionic acid 79-93 peroxisome proliferator activated receptor alpha Homo sapiens 116-125 16950524-7 2007 Neurohistological examinations of hippocampus and adjacent white matter (external capsule) of PPA treated rats revealed increased reactive astrogliosis (GFAP immunoreactivity) and activated microglia (CD68 immunoreactivity) suggestive of a neuroinflammatory process. propionic acid 94-97 glial fibrillary acidic protein Rattus norvegicus 153-157 16950524-7 2007 Neurohistological examinations of hippocampus and adjacent white matter (external capsule) of PPA treated rats revealed increased reactive astrogliosis (GFAP immunoreactivity) and activated microglia (CD68 immunoreactivity) suggestive of a neuroinflammatory process. propionic acid 94-97 Cd68 molecule Rattus norvegicus 201-205 17125264-4 2006 Optimization of the bridgehead substituent led to propionic acid 29 (BG9928), which retained high potency (hA1, Ki=7 nM) and selectivity for the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B receptor) with improved oral efficacy in the rat diuresis model (ED50=0.01 mg/kg) as well as high oral bioavailability in rat, dog, and cynomolgus monkey. propionic acid 50-64 BCL2 related protein A1 Homo sapiens 107-110 17125264-4 2006 Optimization of the bridgehead substituent led to propionic acid 29 (BG9928), which retained high potency (hA1, Ki=7 nM) and selectivity for the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B receptor) with improved oral efficacy in the rat diuresis model (ED50=0.01 mg/kg) as well as high oral bioavailability in rat, dog, and cynomolgus monkey. propionic acid 50-64 adenosine A1 receptor Rattus norvegicus 145-166 17125264-4 2006 Optimization of the bridgehead substituent led to propionic acid 29 (BG9928), which retained high potency (hA1, Ki=7 nM) and selectivity for the adenosine A1 receptor (915-fold versus adenosine A2A receptor; 12-fold versus adenosine A2B receptor) with improved oral efficacy in the rat diuresis model (ED50=0.01 mg/kg) as well as high oral bioavailability in rat, dog, and cynomolgus monkey. propionic acid 50-64 adenosine A2a receptor Rattus norvegicus 184-206 17638969-8 2007 Partial least squares models generated from FTIR/ATR spectra by direct measurement of cheeses gave standard errors of cross-validation of 9.7 mg/100 g of cheese for propionic acid, 9.3 mg/100 g of cheese for acetic acid, and 5.5 mg/100 g of cheese for butyric acid, and correlation coefficients >0.9. propionic acid 165-179 ATR serine/threonine kinase Homo sapiens 49-52 16968296-4 2006 METHODS AND RESULTS: Twenty-nine strains of lactic (LAB) and propionic acid bacteria (PAB) were tested for their ability to remove deoxynivalenol (DON) and fumonisins B1 and B2 (FB1, FB2) from an acid, pH 4, medium. propionic acid 61-75 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 167-176 16843692-4 2006 RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules. propionic acid 67-81 putative methylmalonyl-CoA mutase, mitochondrial Caenorhabditis elegans 25-31 16843692-4 2006 RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules. propionic acid 67-81 Corrinoid adenosyltransferase Caenorhabditis elegans 33-39 16843692-4 2006 RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules. propionic acid 67-81 Methylmalonic aciduria type A homolog, mitochondrial Caenorhabditis elegans 41-47 16843692-4 2006 RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules. propionic acid 67-81 putative methylmalonyl-CoA mutase, mitochondrial Caenorhabditis elegans 165-171 16843692-4 2006 RNA interference against mmcm-1, mmab-1, mmaa-1 in the presence of propionic acid revealed a chemical phenotype of increased methylmalonic acid; deletion mutants of mmcm-1, mmab-1 and mce-1 displayed reduced 1-[(14)C]-propionate incorporation into macromolecules. propionic acid 67-81 VOC domain-containing protein Caenorhabditis elegans 184-189 16206288-6 2006 In vitro treatment with butyrate or propionic acid, but not succinic acid, elicited a positive response in the p53-p53R2 system. propionic acid 36-50 tumor protein p53 Homo sapiens 111-114 16464585-3 2006 Structure-activity relationship study indicated that C3 side chain of Orn as compared to C4 side chain of Lys at P1" position was better suited to inhibit ACE, with propionic acid (C3) derived heterocyclics and unnatural amino acids. propionic acid 165-179 angiotensin I converting enzyme Homo sapiens 155-158 16621530-3 2006 The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARalpha-binding potency. propionic acid 71-85 peroxisome proliferator activated receptor alpha Homo sapiens 113-122 16206288-6 2006 In vitro treatment with butyrate or propionic acid, but not succinic acid, elicited a positive response in the p53-p53R2 system. propionic acid 36-50 ribonucleotide reductase regulatory TP53 inducible subunit M2B Homo sapiens 115-120 16773470-5 2006 We also noticed that after 72 h treatment with 5 mM PA cells showed retracted cytoplasm with bipolar processes containing packed GFAP filaments and disorganized actin stress fibers, as revealed by immunocytochemistry. propionic acid 52-54 glial fibrillary acidic protein Rattus norvegicus 129-133 16773470-7 2006 In conclusion, our results indicate that PA lead to cytoskeletal reorganization and to increased in vitro phosphorylation of Triton-insoluble GFAP and vimentin. propionic acid 41-43 glial fibrillary acidic protein Rattus norvegicus 142-146 16773470-7 2006 In conclusion, our results indicate that PA lead to cytoskeletal reorganization and to increased in vitro phosphorylation of Triton-insoluble GFAP and vimentin. propionic acid 41-43 vimentin Rattus norvegicus 151-159 16391084-4 2006 The aatA mutation with an insertion of the neomycin resistance gene within the aatA coding region showed reduced resistance to acetic acid, formic acid, propionic acid, and lactic acid, whereas the aatA mutation exerted no effects on resistance to various drugs, growth at low pH (adjusted with HCl), assimilation of acetic acid, or resistance to citric acid. propionic acid 153-167 AatA, outermembrane protein Escherichia coli 4-8 16391084-4 2006 The aatA mutation with an insertion of the neomycin resistance gene within the aatA coding region showed reduced resistance to acetic acid, formic acid, propionic acid, and lactic acid, whereas the aatA mutation exerted no effects on resistance to various drugs, growth at low pH (adjusted with HCl), assimilation of acetic acid, or resistance to citric acid. propionic acid 153-167 AatA, outermembrane protein Escherichia coli 79-83 16391084-4 2006 The aatA mutation with an insertion of the neomycin resistance gene within the aatA coding region showed reduced resistance to acetic acid, formic acid, propionic acid, and lactic acid, whereas the aatA mutation exerted no effects on resistance to various drugs, growth at low pH (adjusted with HCl), assimilation of acetic acid, or resistance to citric acid. propionic acid 153-167 AatA, outermembrane protein Escherichia coli 79-83 19804142-2 2005 Ambrisentan is an oral, once-daily, endothelin type-A receptor (ETA)-selective, propanoic acid class ERA under clinical investigation for the treatment of PAH. propionic acid 80-94 endothelin receptor type A Homo sapiens 36-62 15837331-1 2005 We have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2. propionic acid 53-67 glutamate metabotropic receptor 2 Rattus norvegicus 104-137 16841750-3 2006 According to the Monod type kinetics, the maximum uptake rates (km) of butyric acid (HBu), propionic acid (HPr) and acetic acid (HAc) are testified as 18, 14, 13 d(-1), and their half saturation concentrations (Ks) are 110, 120, 160 g COD/m3, respectively. propionic acid 91-105 haptoglobin-related protein Homo sapiens 107-110 15946960-11 2005 They hardly migrated at pHe 6.6 or 7.5, when NHE was inhibited, or when NHE activity was stimulated by loading cells with propionic acid. propionic acid 122-136 solute carrier family 9 member C1 Homo sapiens 72-75 19804142-2 2005 Ambrisentan is an oral, once-daily, endothelin type-A receptor (ETA)-selective, propanoic acid class ERA under clinical investigation for the treatment of PAH. propionic acid 80-94 endothelin receptor type A Homo sapiens 64-67