PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29749497-8	2018	Short interfering RNA-directed silencing of SMAD2 reversed the upregulated proliferation and migration and the expression level of type II collagen and aggrecan induced by the miR-486-5p inhibitor.	mir-486	176-183	SMAD family member 2	Homo sapiens	44-49
29316891-8	2018	Besides, the relationship between miR-486-5p and PTEN were determined by dual luciferase reporter gene assay.	mir-486	34-41	phosphatase and tensin homolog	Homo sapiens	49-53
29229876-7	2017	In short, these data show that miR-486-5p overexpression can inhibit TGF-beta2-induced proliferation, invasion and EMT in SRA01/04 cells by repressing Smad2/Smad3 signalling, implying that miR-486-5p may be an effective target to interfere in the progression of PCO.	mir-486	31-38	transforming growth factor beta 2	Homo sapiens	69-78
29229876-7	2017	In short, these data show that miR-486-5p overexpression can inhibit TGF-beta2-induced proliferation, invasion and EMT in SRA01/04 cells by repressing Smad2/Smad3 signalling, implying that miR-486-5p may be an effective target to interfere in the progression of PCO.	mir-486	31-38	SMAD family member 2	Homo sapiens	151-156
29229876-7	2017	In short, these data show that miR-486-5p overexpression can inhibit TGF-beta2-induced proliferation, invasion and EMT in SRA01/04 cells by repressing Smad2/Smad3 signalling, implying that miR-486-5p may be an effective target to interfere in the progression of PCO.	mir-486	31-38	SMAD family member 3	Homo sapiens	157-162
27650731-10	2016	Thus, delivery of ECFC exosomes reduces ischemic kidney injury via transfer of miR-486-5p targeting PTEN.	mir-486	79-86	phosphatase and tensin homolog	Homo sapiens	100-104
28881785-0	2017	MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma.	mir-486	0-7	NIMA related kinase 2	Homo sapiens	42-46
25857263-9	2015	Noteworthy, MAF overexpression was able to partially reverse the effects of miR-486-3p overexpression on erythroid versus megakaryocyte lineage choice.	mir-486	76-83	MAF bZIP transcription factor	Homo sapiens	12-15
26871282-7	2016	Ovarian cancer cells transfected with miR-486-5p mimics showed decreased OLFM4 mRNA expression, and ovarian cancer cells treated with E2 showed reduced cellular miR-486-5p levels.	mir-486	38-45	olfactomedin 4	Homo sapiens	73-78
25515961-2	2015	Using microarray-based miRNA profiling, we found that miRNA 486 (miR-486) is significantly upregulated in chronic myeloid leukemia (CML) compared with normal CD34(+) cells, particularly in the megakaryocyte-erythroid progenitor population.	mir-486	65-72	CD34 molecule	Homo sapiens	158-162
25104088-7	2014	Together, we conclude that miR-486-5p exerts its antiproliferative function by directly downregulating PIM-1 expression.	mir-486	27-34	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	103-108
25475121-7	2015	In addition, PIK3R1 knockdown mimicked the effects of miR-486-5p overexpression by inhibiting HCC growth, migration, and invasion.	mir-486	54-61	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	13-19
23474761-11	2014	Reduced expression of ARHGAP5 considerably inhibited lung cancer cell migration and invasion, resembling that of miR-486-5p overexpression.	mir-486	113-120	Rho GTPase activating protein 5	Mus musculus	22-29
23474761-12	2014	miR-486-5p may act as a tumor-suppressor contributing to the progression and metastasis of NSCLC by targeting ARHGAP5.	mir-486	0-7	Rho GTPase activating protein 5	Mus musculus	110-117
34080770-7	2021	Meanwhile, we demonstrated that miR-486-3p regulates NaF-induced upregulation of CyclinD1 by directly targeting its 3"-untranslated region (3"-UTR).	mir-486	32-39	C-X-C motif chemokine ligand 8	Homo sapiens	53-56
34080770-7	2021	Meanwhile, we demonstrated that miR-486-3p regulates NaF-induced upregulation of CyclinD1 by directly targeting its 3"-untranslated region (3"-UTR).	mir-486	32-39	cyclin D1	Homo sapiens	81-89
34118593-14	2021	CONCLUSION: This study demonstrated that miR-486-3p targets CTNNBIP1, thus activating the Wnt/beta-catenin signaling pathway to promote osteogenesis of BMSCs.	mir-486	41-48	catenin beta interacting protein 1	Mus musculus	60-68
34118593-14	2021	CONCLUSION: This study demonstrated that miR-486-3p targets CTNNBIP1, thus activating the Wnt/beta-catenin signaling pathway to promote osteogenesis of BMSCs.	mir-486	41-48	catenin beta 1	Homo sapiens	94-106
33660813-0	2021	Long noncoding RNA XIST enhances cerebral ischemia-reperfusion injury by regulating miR-486-5p and GAB2.	mir-486	84-91	X inactive specific transcript	Homo sapiens	19-23
35484551-11	2022	The expression of Snail, which induces EMT, was shown to be restrained by miR-486-3p.	mir-486	74-81	snail family zinc finger 1	Mus musculus	18-23
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	mir-486	66-73	insulin like growth factor 1	Homo sapiens	0-28
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	mir-486	66-73	insulin like growth factor 1	Homo sapiens	30-34
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	mir-486	133-140	insulin like growth factor 1	Homo sapiens	0-28
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	mir-486	133-140	insulin like growth factor 1	Homo sapiens	30-34
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	mir-486	133-140	insulin like growth factor 1	Homo sapiens	82-86
33977502-11	2021	In summary, H/R-treated HPVEC-derived exosomally expressing miR-486-5p inhibitor significantly inhibited the proliferation, migration and invasion of trophoblast cells via downregulation of IGF1.	mir-486	60-67	insulin like growth factor 1	Homo sapiens	190-194
33660813-14	2021	CONCLUSIONS: Our results indicated that XIST promoted cerebral I/R injury via modulating miR-486-5p and GAB2.	mir-486	89-96	X inactive specific transcript	Homo sapiens	40-44
32086739-7	2020	Moreover, overexpression of MGMT restored miR-486-3p-induced chemosensitivity to TMZ.	mir-486	42-49	O-6-methylguanine-DNA methyltransferase	Homo sapiens	28-32
32198055-0	2020	MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells.	mir-486	0-7	membrane associated guanylate kinase, WW and PDZ domain containing 1	Homo sapiens	20-25
32519472-7	2020	We demonstrated that KIAA1199 can function as a direct binding target for miR-486-5p and that miR-486-5p overexpression can attenuate proliferation and migration of NSCLC cells via regulating the EGFR signaling pathways.	mir-486	74-81	cell migration inducing protein, hyaluronan binding	Mus musculus	21-29
32198055-0	2020	MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells.	mir-486	0-7	RAP1A, member of RAS oncogene family	Homo sapiens	26-30
32198055-0	2020	MiR-486-5p-directed MAGI1/Rap1/RASSF5 signaling pathway contributes to hydroquinone-induced inhibition of erythroid differentiation in K562 cells.	mir-486	0-7	Ras association domain family member 5	Homo sapiens	31-37
31528235-3	2019	MiR-486-5p is a microRNA that known to function as a tumor suppressor, and bioinformatics analysis predicts that Dock-1 has a binding site of miR-486-5p.	mir-486	142-149	dedicator of cytokinesis 1	Mus musculus	113-119
31501407-12	2019	CONCLUSIONS The miR-486-5p/KIAA1199/EMT axis might play a critical role in PTC invasion and metastasis and offers a potential therapeutic strategy for PTC.	mir-486	16-23	cell migration inducing hyaluronidase 1	Homo sapiens	27-35
31528235-7	2019	Dock1 overexpression reversed the effect caused by the overexpression of miR-486-5p.	mir-486	73-80	dedicator of cytokinesis 1	Mus musculus	0-5
30844685-11	2019	In addition, BMSC-exo repressed the expression of PTEN in H9C2 cells via miR-486-5p, and subsequently activated the PI3K/AKT pathway in vitro.	mir-486	73-80	phosphatase and tensin homolog	Rattus norvegicus	50-54