PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21086175-0 2011 Apicidin suppresses transcription of 17beta-hydroxysteroid dehydrogenase type 1 in endometrial adenocarcinoma cells. apicidin 0-8 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 37-79 22027828-4 2011 When endothelial cells were treated with the HDAC3 inhibitor, apicidin, or shRNA-HDAC3 knockdown, IFN-gamma-induced galectin-9 expression was abolished. apicidin 62-70 interferon gamma Homo sapiens 98-107 22027828-4 2011 When endothelial cells were treated with the HDAC3 inhibitor, apicidin, or shRNA-HDAC3 knockdown, IFN-gamma-induced galectin-9 expression was abolished. apicidin 62-70 galectin 9 Homo sapiens 116-126 22903717-8 2012 Interestingly, the acetylation of a subset of the mitotic proteins can be further enhanced by treatment with apicidin, a small molecule inhibitor with specificity for HDAC3, suggesting that their acetylation may be regulated by HDAC3 in mitosis. apicidin 109-117 histone deacetylase 3 Homo sapiens 167-172 22903717-8 2012 Interestingly, the acetylation of a subset of the mitotic proteins can be further enhanced by treatment with apicidin, a small molecule inhibitor with specificity for HDAC3, suggesting that their acetylation may be regulated by HDAC3 in mitosis. apicidin 109-117 histone deacetylase 3 Homo sapiens 228-233 22903717-9 2012 In this chapter, we describe the various techniques using NudC as an example of an acetylated protein that is sensitive to apicidin treatment in mitosis. apicidin 123-131 nuclear distribution C, dynein complex regulator Homo sapiens 58-62 20537879-5 2011 Apicidin sensitised towards CD95 also in the intact organ, i.e. in the isolated perfused mouse liver. apicidin 0-8 Fas (TNF receptor superfamily member 6) Mus musculus 28-32 21086175-3 2011 ER(+) ISH, but not ER(-)02 ISH, cells were significantly susceptible to apicidin induced death, and we further used ER(-)ISH cells to study the effect of apicidin on cellular levels of HSD17B1 transcript and protein. apicidin 154-162 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 185-192 21086175-6 2011 However, chromatin immunoprecipitation analysis revealed that apicidin significantly decreased occupation of the first exon of the HSD17B1 gene by Polymerase II. apicidin 62-70 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 131-138 21455583-5 2011 In addition, apicidin, a histone deacetylase inhibitor, was shown to attenuate the invasion, migration and MMP-9 expression in MDA-MB-231 cells. apicidin 13-21 matrix metallopeptidase 9 Homo sapiens 107-112 20888352-4 2011 VPA, SB, TSA, MS-275, and apicidin also upregulated levels of the neuroprotective heat shock protein 70 (HSP70) in rat astrocytes. apicidin 26-34 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 82-103 20888352-4 2011 VPA, SB, TSA, MS-275, and apicidin also upregulated levels of the neuroprotective heat shock protein 70 (HSP70) in rat astrocytes. apicidin 26-34 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 105-110 20580868-3 2010 Non-toxic and functional doses of all HDACi but apicidin, similarly sensitized different leukemic T cell lines to TRAIL-induced apoptosis, while they showed no effect on the resistance of normal T lymphocytes. apicidin 48-56 TNF superfamily member 10 Homo sapiens 114-119 20812760-9 2010 We further showed that acetylation of APC1 and NudC was enhanced by apicidin treatment, suggesting that their acetylation was regulated by histone deacetylase. apicidin 68-76 solute carrier family 25 member 24 Homo sapiens 38-42 20812760-9 2010 We further showed that acetylation of APC1 and NudC was enhanced by apicidin treatment, suggesting that their acetylation was regulated by histone deacetylase. apicidin 68-76 nuclear distribution C, dynein complex regulator Homo sapiens 47-51 20527723-0 2010 Apicidin upregulates PHD2 prolyl hydroxylase gene expression in cervical cancer cells. apicidin 0-8 egl-9 family hypoxia inducible factor 1 Homo sapiens 21-25 20470885-7 2010 Analysis of TGF-beta-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs. apicidin 158-166 transforming growth factor, beta 1 Mus musculus 12-20 20470885-7 2010 Analysis of TGF-beta-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs. apicidin 158-166 a disintegrin and metallopeptidase domain 12 (meltrin alpha) Mus musculus 29-35 20470885-7 2010 Analysis of TGF-beta-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs. apicidin 158-166 mitogen-activated protein kinase 1 Mus musculus 62-65 20527723-2 2010 We used HeLa, CaSki, C33A, and SiHa cervical cancer cells to show the effect of apicidin on cellular levels of PHD2 enzyme. apicidin 80-88 egl-9 family hypoxia inducible factor 1 Homo sapiens 111-115 20527723-3 2010 Using reverse transcription, real-time quantitative PCR, and western blot analysis, we established that apicidin upregulates PHD2 transcript and protein levels in HeLa, CaSki, and C33A, but not in SiHa cervical cancer cells. apicidin 104-112 egl-9 family hypoxia inducible factor 1 Homo sapiens 125-129 20527723-4 2010 Bisulfite sequencing showed that the increase in PHD2 expression was accompanied by demethylation ofCpG islands located in the first exon of the PHD2 gene.As decreased PHD2 expression supports tumor progression, our findings may validate the usefulness of apicidin as an anticancer drug. apicidin 256-264 egl-9 family hypoxia inducible factor 1 Homo sapiens 49-53 20527723-4 2010 Bisulfite sequencing showed that the increase in PHD2 expression was accompanied by demethylation ofCpG islands located in the first exon of the PHD2 gene.As decreased PHD2 expression supports tumor progression, our findings may validate the usefulness of apicidin as an anticancer drug. apicidin 256-264 egl-9 family hypoxia inducible factor 1 Homo sapiens 145-149 20527723-4 2010 Bisulfite sequencing showed that the increase in PHD2 expression was accompanied by demethylation ofCpG islands located in the first exon of the PHD2 gene.As decreased PHD2 expression supports tumor progression, our findings may validate the usefulness of apicidin as an anticancer drug. apicidin 256-264 egl-9 family hypoxia inducible factor 1 Homo sapiens 145-149 20181093-10 2010 Similar effects were seen with a structurally dissimilar HDAC inhibitor apicidin. apicidin 72-80 histone deacetylase 9 Homo sapiens 57-61 19268463-0 2009 Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells. apicidin 17-25 TNF superfamily member 10 Homo sapiens 36-41 19765194-5 2009 Other HDAC inhibitors--sodium butyrate, trichostatin A, and Class I HDAC-specific inhibitors MS-275 and apicidin, --all mimicked the ability of VPA to induce HSP70. apicidin 104-112 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 158-163 18993024-0 2009 Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells. apicidin 0-8 phospholipase C gamma 1 Homo sapiens 19-42 18993024-2 2009 We used Hut-78 T lymphoma cells to demonstrate the effect of apicidin on cellular levels of the PLCgamma1 molecule. apicidin 61-69 phospholipase C gamma 1 Homo sapiens 96-105 18993024-5 2009 Moreover, we determined that apicidin reduces the half-life of PLCgamma1 mRNAs from approximately 2 to 4h. apicidin 29-37 phospholipase C gamma 1 Homo sapiens 63-72 18993024-6 2009 Since PLCgamma1 is considered a key molecule in signal transduction in T cells, apicidin may be useful in the treatment of some autoimmune diseases in which autoreactive T cells occur. apicidin 80-88 phospholipase C gamma 1 Homo sapiens 6-15 19567677-4 2009 Down-regulation of the gene by either small interfering RNAs targeting Nanog or histone deacetylase inhibitor apicidin causes reversion of expression pattern of embryonic stem cell signature including Oct4, Sox2, and their target genes, leading to cell cycle arrest, inhibition of colony formation in soft agar, and induction of differentiation into all three germ layers. apicidin 110-118 POU class 5 homeobox 1 Homo sapiens 201-205 19567677-4 2009 Down-regulation of the gene by either small interfering RNAs targeting Nanog or histone deacetylase inhibitor apicidin causes reversion of expression pattern of embryonic stem cell signature including Oct4, Sox2, and their target genes, leading to cell cycle arrest, inhibition of colony formation in soft agar, and induction of differentiation into all three germ layers. apicidin 110-118 SRY-box transcription factor 2 Homo sapiens 207-211 19956841-0 2010 Anti-tumor effect of apicidin on Ishikawa human endometrial cancer cells both in vitro and in vivo by blocking histone deacetylase 3 and 4. apicidin 21-29 histone deacetylase 3 Homo sapiens 111-138 19956841-7 2010 Apicidin suppressed the tumor growth of transplanted Ishikawa cells, the expression of proliferative cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) in tumor xenograft model, respectively. apicidin 0-8 proliferating cell nuclear antigen Homo sapiens 123-127 19956841-7 2010 Apicidin suppressed the tumor growth of transplanted Ishikawa cells, the expression of proliferative cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) in tumor xenograft model, respectively. apicidin 0-8 vascular endothelial growth factor A Homo sapiens 133-167 19956841-7 2010 Apicidin suppressed the tumor growth of transplanted Ishikawa cells, the expression of proliferative cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) in tumor xenograft model, respectively. apicidin 0-8 vascular endothelial growth factor A Homo sapiens 169-173 19956841-8 2010 The inhibitory effect of apicidin on tumor growth was mediated in part through the down-regulation of HDAC3 and HDAC4. apicidin 25-33 histone deacetylase 3 Homo sapiens 102-107 19956841-8 2010 The inhibitory effect of apicidin on tumor growth was mediated in part through the down-regulation of HDAC3 and HDAC4. apicidin 25-33 histone deacetylase 4 Homo sapiens 112-117 19956841-9 2010 We suggest that apicidin is an effective anti-tumor agent on human endometrial cancer cells, and acts by regulating cell proliferation and apoptosis through the down-regulation of HDAC3 and HDAC4. apicidin 16-24 histone deacetylase 3 Homo sapiens 180-185 19956841-9 2010 We suggest that apicidin is an effective anti-tumor agent on human endometrial cancer cells, and acts by regulating cell proliferation and apoptosis through the down-regulation of HDAC3 and HDAC4. apicidin 16-24 histone deacetylase 4 Homo sapiens 190-195 19567677-6 2009 Interestingly, embryonic carcinoma cells (NCCIT, NTERA2, and P19) exhibit a higher sensitivity to apicidin in down-regulation of Nanog compared with embryonic stem cells. apicidin 98-106 cyclin dependent kinase inhibitor 2D Homo sapiens 61-64 19567677-6 2009 Interestingly, embryonic carcinoma cells (NCCIT, NTERA2, and P19) exhibit a higher sensitivity to apicidin in down-regulation of Nanog compared with embryonic stem cells. apicidin 98-106 Nanog homeobox Homo sapiens 129-134 19268463-6 2009 Treatment with apicidin resulted in down-regulation of Bcr-Abl and inhibition of its downstream target, PI3K/AKT-NF-kappaB pathway. apicidin 15-23 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 55-62 19268463-7 2009 In addition, apicidin decreased the level of NF-kappaB-dependent Bcl-x(L), leading to caspase activation and Bid cleavage. apicidin 13-21 BCL2 like 1 Homo sapiens 65-73 19268463-8 2009 These results suggest that apicidin may sensitize K562 cells to TRAIL-induced apoptosis through caspase-dependent mitochondrial pathway by regulating expression of Bcr-Abl and its related anti-apoptotic proteins. apicidin 27-35 TNF superfamily member 10 Homo sapiens 64-69 19268463-8 2009 These results suggest that apicidin may sensitize K562 cells to TRAIL-induced apoptosis through caspase-dependent mitochondrial pathway by regulating expression of Bcr-Abl and its related anti-apoptotic proteins. apicidin 27-35 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 164-171 19268463-9 2009 Therefore, the present study suggests that combination of apicidin and TRAIL may be an effective strategy for treating TRAIL-resistant Bcr-Abl expressing CML cells. apicidin 58-66 TNF superfamily member 10 Homo sapiens 119-124 19268463-9 2009 Therefore, the present study suggests that combination of apicidin and TRAIL may be an effective strategy for treating TRAIL-resistant Bcr-Abl expressing CML cells. apicidin 58-66 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 135-142 19268463-0 2009 Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells. apicidin 17-25 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 71-78 19268463-3 2009 In this study, we investigated whether apicidin, a novel histone deacetylase inhibitor, could overcome the TRAIL resistance in CML-derived K562 cells. apicidin 39-47 TNF superfamily member 10 Homo sapiens 107-112 19268463-4 2009 Compared to treatment with apicidin or TRAIL alone, cotreatment with apicidin and TRAIL-induced apoptosis synergistically in K562 cells. apicidin 27-35 TNF superfamily member 10 Homo sapiens 82-87 19268463-4 2009 Compared to treatment with apicidin or TRAIL alone, cotreatment with apicidin and TRAIL-induced apoptosis synergistically in K562 cells. apicidin 69-77 TNF superfamily member 10 Homo sapiens 39-44 19070610-9 2009 These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells. apicidin 122-130 poly(ADP-ribose) polymerase 1 Homo sapiens 32-58 19376607-0 2009 Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo. apicidin 19-27 sulfatase 1 Homo sapiens 47-58 19376607-4 2009 METHODS: We evaluated the effects of apicidin alone or combined with doxorubicin on apoptosis, caspase activity, and phosphorylation of Erk and Akt in SULF1-transfected Huh7 and Hep3B cells in vitro and in vivo. apicidin 37-45 mitogen-activated protein kinase 1 Homo sapiens 136-139 19376607-4 2009 METHODS: We evaluated the effects of apicidin alone or combined with doxorubicin on apoptosis, caspase activity, and phosphorylation of Erk and Akt in SULF1-transfected Huh7 and Hep3B cells in vitro and in vivo. apicidin 37-45 sulfatase 1 Homo sapiens 151-156 19376607-4 2009 METHODS: We evaluated the effects of apicidin alone or combined with doxorubicin on apoptosis, caspase activity, and phosphorylation of Erk and Akt in SULF1-transfected Huh7 and Hep3B cells in vitro and in vivo. apicidin 37-45 MIR7-3 host gene Homo sapiens 169-173 19376607-7 2009 Apicidin also decreased phosphorylation of both Erk and Akt. apicidin 0-8 mitogen-activated protein kinase 1 Homo sapiens 48-51 19376607-7 2009 Apicidin also decreased phosphorylation of both Erk and Akt. apicidin 0-8 AKT serine/threonine kinase 1 Homo sapiens 56-59 19376607-8 2009 Expression of constitutively-active Mek1 and Akt significantly decreased apicidin-induced apoptosis. apicidin 73-81 mitogen-activated protein kinase kinase 1 Homo sapiens 36-40 19376607-8 2009 Expression of constitutively-active Mek1 and Akt significantly decreased apicidin-induced apoptosis. apicidin 73-81 AKT serine/threonine kinase 1 Homo sapiens 45-48 19376607-9 2009 The combination of doxorubicin with apicidin significantly increased the anti-tumor effect in the SULF1-expressing Huh7 and Hep3B cells as compared to either apicidin or doxorubicin alone, both in vitro and in vivo. apicidin 36-44 sulfatase 1 Homo sapiens 98-103 19376607-9 2009 The combination of doxorubicin with apicidin significantly increased the anti-tumor effect in the SULF1-expressing Huh7 and Hep3B cells as compared to either apicidin or doxorubicin alone, both in vitro and in vivo. apicidin 36-44 MIR7-3 host gene Homo sapiens 115-119 19070610-9 2009 These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells. apicidin 122-130 poly(ADP-ribose) polymerase 1 Homo sapiens 60-64 19070610-9 2009 These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells. apicidin 122-130 poly(ADP-ribose) polymerase 1 Homo sapiens 101-105 19070610-9 2009 These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells. apicidin 122-130 poly(ADP-ribose) polymerase 1 Homo sapiens 101-105 19070610-9 2009 These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells. apicidin 122-130 caspase 3 Homo sapiens 172-181 19070610-9 2009 These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells. apicidin 205-213 poly(ADP-ribose) polymerase 1 Homo sapiens 60-64 19070610-10 2009 Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio. apicidin 0-8 caspase 3 Homo sapiens 35-44 19070610-10 2009 Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio. apicidin 0-8 cytochrome c, somatic Homo sapiens 104-116 19070610-10 2009 Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio. apicidin 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 141-144 19070610-10 2009 Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio. apicidin 0-8 BCL2 apoptosis regulator Homo sapiens 145-150 19407971-4 2009 Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. apicidin 154-162 transcription factor AP-2, alpha Mus musculus 68-71 19407971-4 2009 Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. apicidin 154-162 peroxisome proliferator activated receptor gamma Mus musculus 73-82 19407971-4 2009 Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. apicidin 154-162 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 94-104 19407971-4 2009 Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. apicidin 154-162 adducin 1 (alpha) Mus musculus 106-110 19407971-4 2009 Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. apicidin 154-162 sterol regulatory element binding transcription factor 1 Mus musculus 111-118 19407971-4 2009 Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized. apicidin 154-162 adiponectin, C1Q and collagen domain containing Mus musculus 124-135 19267380-1 2009 Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration. apicidin 47-55 histone deacetylase 9 Homo sapiens 92-111 19505402-0 2009 Apicidin, the histone deacetylase inhibitor, suppresses Th1 polarization of murine bone marrow-derived dendritic cells. apicidin 0-8 negative elongation factor complex member C/D, Th1l Mus musculus 56-59 19505402-4 2009 We observed that apicidin significantly attenuated surface molecule expression in LPS-stimulated DCs, suppressed production of interleukin (IL)-12 and proinflammatory cytokines (IL-6 and TNF-alpha) by DCs, and reduced IFN-gama production by T cells. apicidin 17-25 interleukin 6 Mus musculus 178-182 19505402-4 2009 We observed that apicidin significantly attenuated surface molecule expression in LPS-stimulated DCs, suppressed production of interleukin (IL)-12 and proinflammatory cytokines (IL-6 and TNF-alpha) by DCs, and reduced IFN-gama production by T cells. apicidin 17-25 tumor necrosis factor Mus musculus 187-196 19267380-1 2009 Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration. apicidin 47-55 histone deacetylase 9 Homo sapiens 113-117 19267380-3 2009 One analogue proved in some cases to be superior to apicidin as an HDAC inhibitor. apicidin 52-60 histone deacetylase 9 Homo sapiens 67-71 18313654-0 2008 Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. apicidin 43-51 estrogen receptor 1 Homo sapiens 55-72 18275843-0 2008 Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein. apicidin 30-38 histone deacetylase 9 Homo sapiens 0-19 18275843-0 2008 Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein. apicidin 30-38 ATP binding cassette subfamily B member 1 Homo sapiens 80-94 18275843-2 2008 In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression. apicidin 69-77 histone deacetylase 9 Homo sapiens 32-51 18275843-2 2008 In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression. apicidin 69-77 histone deacetylase 9 Homo sapiens 53-57 18275843-2 2008 In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression. apicidin 69-77 ATP binding cassette subfamily B member 1 Homo sapiens 151-155 18275843-3 2008 Furthermore, apicidin dramatically increases the release of a fluorescent P-gp substrate, rhodamine 123, from cells. apicidin 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 74-78 18275843-4 2008 In parallel, apicidin resistance to the apoptotic potential of paclitaxel is associated with induction of P-gp expression in HeLa cells, as evidenced by specific inhibition of P-gp function using either the pharmacological inhibitor verapamil or RNA silencing. apicidin 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 106-110 18275843-4 2008 In parallel, apicidin resistance to the apoptotic potential of paclitaxel is associated with induction of P-gp expression in HeLa cells, as evidenced by specific inhibition of P-gp function using either the pharmacological inhibitor verapamil or RNA silencing. apicidin 13-21 ATP binding cassette subfamily B member 1 Homo sapiens 176-180 18275843-5 2008 We also demonstrate the contribution of apicidin-induced functional P-gp expression to drug resistance using KB cells. apicidin 40-48 ATP binding cassette subfamily B member 1 Homo sapiens 68-72 18275843-7 2008 Although HDAC inhibitors are widely appreciated as a new class of anti-tumor agent, our findings clearly demonstrate that apicidin treatment may lead to P-gp-mediated resistance to other anti-tumor agents, suggesting a need for careful design of clinical applications using HDAC inhibitors. apicidin 122-130 ATP binding cassette subfamily B member 1 Homo sapiens 153-157 18275843-7 2008 Although HDAC inhibitors are widely appreciated as a new class of anti-tumor agent, our findings clearly demonstrate that apicidin treatment may lead to P-gp-mediated resistance to other anti-tumor agents, suggesting a need for careful design of clinical applications using HDAC inhibitors. apicidin 122-130 histone deacetylase 9 Homo sapiens 274-278 18313654-0 2008 Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. apicidin 43-51 estrogen receptor 1 Homo sapiens 74-76 18313654-5 2008 In MCF-7 cells, the expression of ERalpha and ERbeta was decreased in a dose-dependent manner after apicidin treatment. apicidin 100-108 estrogen receptor 1 Homo sapiens 34-41 18313654-5 2008 In MCF-7 cells, the expression of ERalpha and ERbeta was decreased in a dose-dependent manner after apicidin treatment. apicidin 100-108 estrogen receptor 2 Homo sapiens 46-52 18313654-7 2008 Apicidin (300 nM) significantly induced expression of p21Waf1 and p27Kip1. apicidin 0-8 cyclin dependent kinase inhibitor 1B Homo sapiens 66-73 18313654-12 2008 Additionally, apicidin significantly increased the bax/bcl-2 ratio in MCF-7 cells. apicidin 14-22 BCL2 associated X, apoptosis regulator Homo sapiens 51-54 18313654-12 2008 Additionally, apicidin significantly increased the bax/bcl-2 ratio in MCF-7 cells. apicidin 14-22 BCL2 apoptosis regulator Homo sapiens 55-60 18313654-13 2008 These results suggest that apicidin inhibits proliferation of ER-positive MCF-7 breast cancer cells by altering the expression of cell cycle regulator proteins and inducing apoptotic cell death. apicidin 27-35 estrogen receptor 1 Homo sapiens 62-64 18313654-14 2008 These distinctive cell-specific effects of apicidin on the modulation of cell cycle arrest and apoptosis may be associated with ERalpha-mediated transcriptional regulation. apicidin 43-51 estrogen receptor 1 Homo sapiens 128-135 17929017-3 2008 In this study, we selected three structurally different histone deacetylase (HDAC) inhibitors, apicidin, MS275, and sodium butyrate that activate p38, to probe the signal pathway from activin A to p38 in chronic myeloid leukemia (CML)-derived K562 cells. apicidin 95-103 mitogen-activated protein kinase 14 Homo sapiens 146-149 17828306-2 2008 Here, we report that DNMT1 abnormally expressed in HeLa cells is downregulated by a histone deacetylase (HDAC) inhibitor apicidin, which is correlated with induction of repressive histone modifications on the promoter site. apicidin 121-129 DNA methyltransferase 1 Homo sapiens 21-26 18288380-7 2008 Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines. apicidin 0-8 cyclin dependent kinase 2 Homo sapiens 51-55 18288380-7 2008 Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines. apicidin 0-8 cyclin D1 Homo sapiens 83-92 18288380-7 2008 Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 186-190 18288380-7 2008 Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines. apicidin 0-8 cyclin dependent kinase inhibitor 1B Homo sapiens 195-202 18288380-9 2008 Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of p53 and the downstream activation of ERK in MCF10A-ras cells. apicidin 51-59 tumor protein p53 Homo sapiens 89-92 18288380-9 2008 Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of p53 and the downstream activation of ERK in MCF10A-ras cells. apicidin 51-59 mitogen-activated protein kinase 1 Homo sapiens 126-129 18288380-11 2008 In addition, apicidin significantly increased the levels of ERK1/2 phosphorylation in MCF10A-ras cells. apicidin 13-21 mitogen-activated protein kinase 3 Homo sapiens 60-66 18288380-12 2008 Therefore, the apicidin-mediated ERK pathway appears to play an important role in modulating the pro-apoptotic pathway in MCF10A-ras cells. apicidin 15-23 mitogen-activated protein kinase 1 Homo sapiens 33-36 17828306-3 2008 Apicidin selectively represses the expression of DNMT1 among DNMTs in HeLa cells, independent of cell cycle arrest at G0/G1. apicidin 0-8 DNA methyltransferase 1 Homo sapiens 49-54 17828306-7 2008 The downregulation of DNMT1 expression seems to require de novo protein synthesis, because the apicidin effect is antagonized by cycloheximide treatment. apicidin 95-103 DNA methyltransferase 1 Homo sapiens 22-27 17868033-6 2008 MS-275 was HDAC1-selective, MGCD0103 was HDAC1- and HDAC2-selective, apicidin was HDAC2- and HDAC3-selective and valproic acid was a specific inhibitor of class I HDACs. apicidin 69-77 histone deacetylase 2 Homo sapiens 82-87 17910885-0 2007 Mechanisms of human gamma-globin transcriptional induction by apicidin involves p38 signaling to chromatin. apicidin 62-70 hemoglobin subunit gamma 1 Homo sapiens 20-32 17935135-12 2008 Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia. apicidin 7-15 von Hippel-Lindau tumor suppressor Homo sapiens 103-107 17935135-12 2008 Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia. apicidin 7-15 histone deacetylase 9 Homo sapiens 20-24 17935135-12 2008 Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia. apicidin 7-15 histone deacetylase 9 Homo sapiens 72-76 18504399-3 2008 The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA. apicidin 20-28 factor interacting with PAPOLA and CPSF1 Homo sapiens 168-174 18504399-3 2008 The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA. apicidin 20-28 factor interacting with PAPOLA and CPSF1 Homo sapiens 223-229 18504399-3 2008 The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA. apicidin 20-28 platelet derived growth factor receptor alpha Homo sapiens 230-236 18504399-4 2008 In this study, we analyzed the mechanism by which the protein level of FIP1L1-PDGFRalpha is decreased by apicidin and n-butyrate. apicidin 105-113 factor interacting with PAPOLA and CPSF1 Homo sapiens 71-77 18504399-8 2008 RESULTS: When apicidin- and n-butyrate-treated EoL-1 cells were incubated in the presence of actinomycin D, the decrease in the protein level of FIP1L1-PDGFRalpha was significantly enhanced when compared with controls. apicidin 14-22 factor interacting with PAPOLA and CPSF1 Homo sapiens 145-151 18504399-10 2008 Apicidin and n-butyrate induced the continuous phosphorylation of eIF-2alpha for up to 8 days. apicidin 0-8 eukaryotic translation initiation factor 2A Homo sapiens 66-76 17910885-0 2007 Mechanisms of human gamma-globin transcriptional induction by apicidin involves p38 signaling to chromatin. apicidin 62-70 mitogen-activated protein kinase 14 Homo sapiens 80-83 17910885-2 2007 The HDAC inhibitor apicidin was recently reported as a powerful inducer of HbF via a mechanism involving p38 signaling. apicidin 19-27 mitogen-activated protein kinase 14 Homo sapiens 105-108 17910885-4 2007 First, we compared histone 3 (H3) acetylation patterns of approximately 70kb beta-globin loci in K562 erythroid versus HeLa cells upon apicidin treatment by chromatin immunoprecipitation assays. apicidin 135-143 H3 clustered histone 14 Homo sapiens 19-32 17910885-4 2007 First, we compared histone 3 (H3) acetylation patterns of approximately 70kb beta-globin loci in K562 erythroid versus HeLa cells upon apicidin treatment by chromatin immunoprecipitation assays. apicidin 135-143 hemoglobin subunit beta Homo sapiens 77-88 17910885-6 2007 Inhibition of p38 signaling blocks the effects of apicidin-induced gamma-globin expression and H3 acetylation. apicidin 50-58 mitogen-activated protein kinase 14 Homo sapiens 14-17 17910885-6 2007 Inhibition of p38 signaling blocks the effects of apicidin-induced gamma-globin expression and H3 acetylation. apicidin 50-58 hemoglobin subunit gamma 1 Homo sapiens 67-79 17910885-7 2007 In parallel, we assessed the recruitment of transcriptional complex to beta-globin locus following apicidin treatment. apicidin 99-107 hemoglobin subunit beta Homo sapiens 71-82 17910885-10 2007 Collectively, our results provide a molecular basis to elucidate the underlying mechanisms involving p38 signaling pathway in the inducement of gamma-globin transcriptional expression by apicidin. apicidin 187-195 mitogen-activated protein kinase 14 Homo sapiens 101-104 17910885-10 2007 Collectively, our results provide a molecular basis to elucidate the underlying mechanisms involving p38 signaling pathway in the inducement of gamma-globin transcriptional expression by apicidin. apicidin 187-195 hemoglobin subunit gamma 1 Homo sapiens 144-156 17675290-3 2007 We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin. apicidin 39-47 coagulation factor III, tissue factor Homo sapiens 126-128 17407153-4 2007 In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells. apicidin 33-41 histone deacetylase 9 Homo sapiens 18-22 17407153-4 2007 In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells. apicidin 33-41 cyclin D3 Homo sapiens 182-191 17407153-4 2007 In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells. apicidin 33-41 histone deacetylase 9 Homo sapiens 207-211 17407153-5 2007 We found that apicidin increases the transcriptional activity of cyclin D3 gene, which results in accumulation of cyclin D3 mRNA and protein. apicidin 14-22 cyclin D3 Homo sapiens 65-74 17407153-5 2007 We found that apicidin increases the transcriptional activity of cyclin D3 gene, which results in accumulation of cyclin D3 mRNA and protein. apicidin 14-22 cyclin D3 Homo sapiens 114-123 17407153-6 2007 Apicidin-induced cyclin D3 expression is mediated by Sp1 sites within the cyclin D3 promoter. apicidin 0-8 cyclin D3 Homo sapiens 17-26 17407153-6 2007 Apicidin-induced cyclin D3 expression is mediated by Sp1 sites within the cyclin D3 promoter. apicidin 0-8 cyclin D3 Homo sapiens 74-83 17407153-7 2007 Apicidin-mediated cyclin D3 expression is attenuated by rottlerin, a specific protein kinase C-delta (PKC-delta) inhibitor, but not mitogen-activated protein kinases (MAPKs) inhibitors. apicidin 0-8 cyclin D3 Homo sapiens 18-27 17407153-8 2007 Furthermore, suppression of PKC-delta expression by transfection with its siRNA prominently attenuated apicidin-induced cyclin D3 expression. apicidin 103-111 cyclin D3 Homo sapiens 120-129 17407153-9 2007 These results indicate that the cyclin D3 induction caused by apicidin was associated with PKC-delta signaling pathway not MAPKs signaling pathways. apicidin 62-70 cyclin D3 Homo sapiens 32-41 17407153-10 2007 Taken together, these results suggest that the activation of cyclin D3 transcription by HDAC inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of PKC-delta. apicidin 103-111 cyclin D3 Homo sapiens 61-70 17407153-10 2007 Taken together, these results suggest that the activation of cyclin D3 transcription by HDAC inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of PKC-delta. apicidin 103-111 histone deacetylase 9 Homo sapiens 88-92 17257588-0 2007 PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. apicidin 81-89 protein kinase C epsilon Homo sapiens 0-10 17257588-0 2007 PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. apicidin 81-89 gelsolin Homo sapiens 28-36 17257588-2 2007 In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells. apicidin 148-156 protein kinase C epsilon Homo sapiens 46-49 17257588-2 2007 In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells. apicidin 148-156 gelsolin Homo sapiens 102-110 17257588-3 2007 Apicidin induces gelsolin mRNA independently of the de novo protein synthesis. apicidin 0-8 gelsolin Homo sapiens 17-25 17257588-5 2007 Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process. apicidin 133-141 protein kinase C epsilon Homo sapiens 27-37 17257588-5 2007 Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process. apicidin 133-141 gelsolin Homo sapiens 121-129 17257588-6 2007 In parallel, apicidin induction of gelsolin is antagonized by the inhibition of Sp1 using dominant-negative Sp1 or specific Sp1 inhibitor mithramycin, and inhibition of PKC leads to suppression of Sp1 promoter activity. apicidin 13-21 gelsolin Homo sapiens 35-43 17257588-7 2007 Our results provide mechanistic insights into molecular mechanisms of gelsolin induction by apicidin. apicidin 92-100 gelsolin Homo sapiens 70-78 17541273-7 2007 RESULTS: Treatment of EoL-1 cells with apicidin at 100 nM or n-butyrate at 500 microM decreased the levels of FIP1L1-PDGFRalpha protein and phosphorylated-Stat5, while that with trichostatin A at 30 nM did not. apicidin 39-47 factor interacting with PAPOLA and CPSF1 Homo sapiens 110-116 17258775-4 2007 It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils. apicidin 25-33 platelet derived growth factor receptor alpha Homo sapiens 188-194 17258775-4 2007 It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils. apicidin 25-33 integrin subunit beta 7 Homo sapiens 270-284 17258775-4 2007 It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils. apicidin 25-33 C-C motif chemokine receptor 1 Homo sapiens 286-290 17258775-4 2007 It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils. apicidin 25-33 C-C motif chemokine receptor 3 Homo sapiens 296-300 17273746-3 2007 Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1alpha protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines. apicidin 48-56 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-100 17273746-3 2007 Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1alpha protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines. apicidin 48-56 hypoxia inducible factor 1 subunit alpha Homo sapiens 90-95 17541273-8 2007 CONCLUSIONS: The decrease in the level of FIP1L1-PDGFRalpha protein caused by apicidin and n-butyrate might be one of the mechanisms by which EoL-1 cells are induced to differentiate into eosinophils by these HDAC inhibitors. apicidin 78-86 factor interacting with PAPOLA and CPSF1 Homo sapiens 42-48 16628233-2 2006 Here, we demonstrate a new mechanism for activation of nuclear factor-kappaB (NF-kappaB) by HDAC inhibitor apicidin and the role of NF-kappaB signaling pathway for mediating differential cellular responses, especially, apoptosis. apicidin 107-115 histone deacetylase 9 Homo sapiens 92-96 16628233-3 2006 Treatment of HeLa cells with apicidin increases transcriptional activity of NF-kappaB and its target gene IL-8 and cIAP-1 induction, which involves the activation of IKK-IkappaBalpha signaling pathway through Sp1-dependent de novo protein synthesis. apicidin 29-37 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 16628233-3 2006 Treatment of HeLa cells with apicidin increases transcriptional activity of NF-kappaB and its target gene IL-8 and cIAP-1 induction, which involves the activation of IKK-IkappaBalpha signaling pathway through Sp1-dependent de novo protein synthesis. apicidin 29-37 baculoviral IAP repeat containing 2 Homo sapiens 115-121 16628233-4 2006 In parallel, apicidin treatment leads to histone hyperacetylation in the IL-8 promoter region independent of NF-kappaB signaling pathway, which is not sufficient for full transcription of IL-8 gene. apicidin 13-21 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 16516150-0 2006 Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. apicidin 30-38 histone deacetylase 9 Homo sapiens 0-19 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 histone deacetylase 9 Homo sapiens 28-32 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 histone deacetylase 9 Homo sapiens 59-63 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 carbonyl reductase 1 Homo sapiens 161-198 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 carbonyl reductase 1 Homo sapiens 200-207 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 222-238 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 prostaglandin-endoperoxide synthase 2 Homo sapiens 240-245 16762634-13 2006 The interaction between SULF1 and apicidin was confirmed in vivo in Huh7 and Hep3B xenografts. apicidin 34-42 sulfatase 1 Homo sapiens 24-29 16762634-13 2006 The interaction between SULF1 and apicidin was confirmed in vivo in Huh7 and Hep3B xenografts. apicidin 34-42 MIR7-3 host gene Homo sapiens 68-72 16870149-0 2006 Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin. apicidin 103-111 histone deacetylase 1 Homo sapiens 15-20 16870149-0 2006 Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin. apicidin 103-111 nuclear factor kappa B subunit 1 Homo sapiens 60-69 16870149-3 2006 In this study, we investigate a possible signaling pathway required for NF-kappaB activation in response to the HDAC inhibitor apicidin. apicidin 127-135 nuclear factor kappa B subunit 1 Homo sapiens 72-81 16870149-4 2006 Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha. apicidin 29-37 nuclear factor kappa B subunit 1 Homo sapiens 90-99 16870149-4 2006 Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha. apicidin 29-37 C-X-C motif chemokine ligand 8 Homo sapiens 140-144 16870149-4 2006 Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha. apicidin 29-37 tumor necrosis factor Homo sapiens 149-158 16870149-5 2006 TNF-alpha expression by apicidin is induced at earlier time points than NF-kappaB activation or IL-8 expression. apicidin 24-32 tumor necrosis factor Homo sapiens 0-9 16870149-8 2006 Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity. apicidin 13-21 nuclear factor kappa B subunit 1 Homo sapiens 36-45 16870149-8 2006 Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity. apicidin 13-21 histone deacetylase 1 Homo sapiens 67-72 16870149-8 2006 Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity. apicidin 13-21 histone deacetylase 1 Homo sapiens 140-145 16870149-8 2006 Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity. apicidin 13-21 nuclear factor kappa B subunit 1 Homo sapiens 192-201 16870149-9 2006 Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin. apicidin 76-84 nuclear factor kappa B subunit 1 Homo sapiens 53-62 16870149-9 2006 Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin. apicidin 76-84 histone deacetylase 1 Homo sapiens 135-140 16870149-9 2006 Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin. apicidin 218-226 nuclear factor kappa B subunit 1 Homo sapiens 53-62 16762634-10 2006 (3) SULF1 enhanced the induction of apoptosis by the HDAC inhibitors apicidin and scriptaid. apicidin 69-77 sulfatase 1 Mus musculus 4-9 16762634-10 2006 (3) SULF1 enhanced the induction of apoptosis by the HDAC inhibitors apicidin and scriptaid. apicidin 69-77 histone deacetylase 9 Homo sapiens 53-57 16762634-12 2006 We also demonstrate that knockdown of SULF1 with shRNA constructs up-regulates phosphorylation of AKT and Erk and attenuates apicidin-induced apoptosis. apicidin 125-133 sulfatase 1 Homo sapiens 38-43 16516150-1 2006 We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. apicidin 52-60 histone deacetylase 9 Homo sapiens 15-34 16516150-1 2006 We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. apicidin 52-60 histone deacetylase 9 Homo sapiens 36-40 16516150-4 2006 Our results demonstrate that regulation of histone modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent. apicidin 85-93 histone deacetylase 9 Homo sapiens 70-74 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 37-45 ATP binding cassette subfamily C member 1 Homo sapiens 158-199 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 37-45 ATP binding cassette subfamily B member 1 Homo sapiens 132-146 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 37-45 ATP binding cassette subfamily B member 1 Homo sapiens 148-152 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 37-45 ATP binding cassette subfamily C member 1 Homo sapiens 201-205 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 37-45 ATP binding cassette subfamily B member 1 Homo sapiens 216-220 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 37-45 ATP binding cassette subfamily C member 1 Homo sapiens 225-229 16049968-5 2006 Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin. apicidin 297-305 ATP binding cassette subfamily C member 1 Homo sapiens 201-205 16049968-6 2006 A P-gp inhibitor (verapamil) and an MRP1 inhibitor (MK571) could independently reverse the resistance to FK228 and apicidin in the drug-resistant clones. apicidin 115-123 ATP binding cassette subfamily B member 1 Homo sapiens 2-6 16049968-6 2006 A P-gp inhibitor (verapamil) and an MRP1 inhibitor (MK571) could independently reverse the resistance to FK228 and apicidin in the drug-resistant clones. apicidin 115-123 ATP binding cassette subfamily C member 1 Homo sapiens 36-40 15710351-4 2005 Histone deacetylase inhibitors trichostatin A (TSA) and apicidin reduced the inhibitory effect of dexamethasone and RU24858 on TTP expression, but the glucocorticoids did not alter TTP mRNA half-life. apicidin 56-64 ZFP36 ring finger protein Homo sapiens 127-130 15710351-4 2005 Histone deacetylase inhibitors trichostatin A (TSA) and apicidin reduced the inhibitory effect of dexamethasone and RU24858 on TTP expression, but the glucocorticoids did not alter TTP mRNA half-life. apicidin 56-64 ZFP36 ring finger protein Homo sapiens 181-184 15210580-5 2004 Other markers for differentiation into eosinophils such as changes in intracellular structure, and expressions of integrin beta7 and major basic protein, and the inhibition of cell proliferation were also induced by apicidin and n-butyrate but not by TSA. apicidin 216-224 integrin subunit beta 7 Homo sapiens 114-128 14687026-0 2004 Apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells by enhancing the activation of mitochondria-dependent caspase cascades. apicidin 0-8 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 55-62 14687026-2 2004 We examined whether apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells. apicidin 20-28 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 75-82 14687026-5 2004 Imatinib/apicidin co-treatment for 48 h resulted in a near complete loss of the full-length XIAP (X-linked inhibitor of apoptosis) protein, with a corresponding increase in the 29-kDa XIAP cleavage product. apicidin 9-17 X-linked inhibitor of apoptosis Homo sapiens 92-96 14687026-5 2004 Imatinib/apicidin co-treatment for 48 h resulted in a near complete loss of the full-length XIAP (X-linked inhibitor of apoptosis) protein, with a corresponding increase in the 29-kDa XIAP cleavage product. apicidin 9-17 X-linked inhibitor of apoptosis Homo sapiens 98-129 14687026-5 2004 Imatinib/apicidin co-treatment for 48 h resulted in a near complete loss of the full-length XIAP (X-linked inhibitor of apoptosis) protein, with a corresponding increase in the 29-kDa XIAP cleavage product. apicidin 9-17 X-linked inhibitor of apoptosis Homo sapiens 184-188 14687026-7 2004 Imatinib/apicidin co-treatment for 48 h produced a prominent decrease in Bcr-Abl protein levels in a caspase-dependent manner. apicidin 9-17 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 73-80 14687026-8 2004 In summary, these data indicate that apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive leukaemia cells through the enhanced activation of the mitochondria-dependent caspase cascades, accompanied by caspase-dependent downregulation of Bcr-Abl and XIAP. apicidin 37-45 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 92-99 14687026-8 2004 In summary, these data indicate that apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive leukaemia cells through the enhanced activation of the mitochondria-dependent caspase cascades, accompanied by caspase-dependent downregulation of Bcr-Abl and XIAP. apicidin 37-45 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 256-263 14687026-8 2004 In summary, these data indicate that apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive leukaemia cells through the enhanced activation of the mitochondria-dependent caspase cascades, accompanied by caspase-dependent downregulation of Bcr-Abl and XIAP. apicidin 37-45 X-linked inhibitor of apoptosis Homo sapiens 268-272 14687026-9 2004 These findings generate a rationale for further investigation of apicidin and imatinib as a potential therapeutic strategy in Bcr-Abl-positive leukaemias. apicidin 65-73 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 126-133 12955081-4 2003 In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin. apicidin 112-120 cyclin dependent kinase inhibitor 1A Homo sapiens 85-88 14581377-0 2003 Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells. apicidin 26-34 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 140-147 14581377-2 2003 The aim of this study was to examine the potential of apicidin to induce apoptosis in human Bcr-Abl-positive leukemia cells and to assess the mechanism of apicidin-induced apoptosis. apicidin 54-62 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 92-99 14581377-8 2003 The disruption of the mitochondrial membrane potential, cytochrome c release into the cytosol, and the mitochondrial Bax translocation were notably demonstrated after the apicidin treatment. apicidin 171-179 cytochrome c, somatic Homo sapiens 56-68 14581377-8 2003 The disruption of the mitochondrial membrane potential, cytochrome c release into the cytosol, and the mitochondrial Bax translocation were notably demonstrated after the apicidin treatment. apicidin 171-179 BCL2 associated X, apoptosis regulator Homo sapiens 117-120 14581377-9 2003 Apicidin induced the proteolytic cleavage of procaspase-9, -3, -8, and poly(ADP-ribose) polymerase. apicidin 0-8 poly(ADP-ribose) polymerase 1 Homo sapiens 45-98 14581377-10 2003 Pretreatment of the K562 cells with the caspase-3 inhibitor, DEVD-CHO, completely inhibited the apicidin-induced apoptosis, suggesting that apicidin-induced apoptosis was caspase-dependent. apicidin 96-104 caspase 3 Homo sapiens 40-49 14581377-10 2003 Pretreatment of the K562 cells with the caspase-3 inhibitor, DEVD-CHO, completely inhibited the apicidin-induced apoptosis, suggesting that apicidin-induced apoptosis was caspase-dependent. apicidin 140-148 caspase 3 Homo sapiens 40-49 14581377-12 2003 Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase. apicidin 78-86 caspase 9 Homo sapiens 35-44 14581377-12 2003 Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase. apicidin 78-86 caspase 3 Homo sapiens 108-124 14581377-12 2003 Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase. apicidin 78-86 poly(ADP-ribose) polymerase 1 Homo sapiens 130-157 14581377-13 2003 The p210 Bcr-Abl protein levels were notably decreased after the apicidin treatment, with near complete loss after 48 h. Reverse transcription-PCR assay demonstrated that the Bcr-Abl mRNA level was also remarkably decreased in a time-dependent manner. apicidin 65-73 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 9-16 14581377-13 2003 The p210 Bcr-Abl protein levels were notably decreased after the apicidin treatment, with near complete loss after 48 h. Reverse transcription-PCR assay demonstrated that the Bcr-Abl mRNA level was also remarkably decreased in a time-dependent manner. apicidin 65-73 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 175-182 14581377-14 2003 CONCLUSIONS: These results indicate that apicidin effectively induces the apoptosis of Bcr-Abl-positive leukemia cells through the activation of the mitochondrial pathway-dependent caspase cascades. apicidin 41-49 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 87-94 14581377-15 2003 The down-regulation of Bcr-Abl mRNA might also be one of the mechanisms implicated in the apicidin-mediated apoptosis in the K562 cells. apicidin 90-98 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 23-30 14581377-16 2003 This study provides the rationale to additionally investigate apicidin as a potential therapeutic agent for the drug-resistant Bcr-Abl-positive leukemia cells. apicidin 62-70 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 127-134 12955081-0 2003 Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway. apicidin 80-88 cyclin dependent kinase inhibitor 1A Homo sapiens 14-17 12955081-0 2003 Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway. apicidin 80-88 cyclin dependent kinase inhibitor 1A Homo sapiens 18-22 12955081-0 2003 Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway. apicidin 80-88 cyclin dependent kinase inhibitor 1A Homo sapiens 23-27 12955081-0 2003 Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway. apicidin 80-88 protein kinase C epsilon Homo sapiens 110-121 12955081-1 2003 We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC). apicidin 108-116 cyclin dependent kinase inhibitor 1A Homo sapiens 46-49 12955081-1 2003 We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC). apicidin 108-116 cyclin dependent kinase inhibitor 1A Homo sapiens 50-54 12955081-1 2003 We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC). apicidin 108-116 cyclin dependent kinase inhibitor 1A Homo sapiens 55-59 12955081-1 2003 We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC). apicidin 108-116 protein kinase C epsilon Homo sapiens 211-214 12955081-4 2003 In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin. apicidin 112-120 cyclin dependent kinase inhibitor 1A Homo sapiens 89-93 12955081-4 2003 In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin. apicidin 112-120 cyclin dependent kinase inhibitor 1A Homo sapiens 94-98 12955081-4 2003 In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin. apicidin 112-120 cyclin dependent kinase inhibitor 1A Homo sapiens 85-98 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 66-74 protein kinase C epsilon Homo sapiens 39-50 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 66-74 protein kinase C epsilon Homo sapiens 179-190 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 66-74 cyclin dependent kinase inhibitor 1A Homo sapiens 198-201 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 66-74 cyclin dependent kinase inhibitor 1A Homo sapiens 202-206 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 66-74 cyclin dependent kinase inhibitor 1A Homo sapiens 207-211 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 236-244 protein kinase C epsilon Homo sapiens 39-50 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 236-244 cyclin dependent kinase inhibitor 1A Homo sapiens 198-201 12955081-5 2003 Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin. apicidin 236-244 cyclin dependent kinase inhibitor 1A Homo sapiens 202-206 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 42-50 cyclin dependent kinase inhibitor 1A Homo sapiens 13-16 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 42-50 cyclin dependent kinase inhibitor 1A Homo sapiens 17-21 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 42-50 cyclin dependent kinase inhibitor 1A Homo sapiens 22-26 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 cyclin dependent kinase inhibitor 1A Homo sapiens 162-165 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 cyclin dependent kinase inhibitor 1A Homo sapiens 166-170 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 cyclin dependent kinase inhibitor 1A Homo sapiens 171-175 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 protein kinase C epsilon Homo sapiens 243-246 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 cyclin dependent kinase inhibitor 1A Homo sapiens 162-165 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 cyclin dependent kinase inhibitor 1A Homo sapiens 166-170 12955081-6 2003 However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin. apicidin 117-125 cyclin dependent kinase inhibitor 1A Homo sapiens 171-175 12955081-7 2003 Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin. apicidin 153-161 protein kinase C epsilon Homo sapiens 59-70 12955081-7 2003 Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin. apicidin 153-161 cyclin dependent kinase inhibitor 1A Homo sapiens 135-138 12955081-7 2003 Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin. apicidin 153-161 cyclin dependent kinase inhibitor 1A Homo sapiens 139-143 12955081-7 2003 Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin. apicidin 153-161 cyclin dependent kinase inhibitor 1A Homo sapiens 144-148 12490313-4 2003 Apicidin (10-100 nM) increased the cells having nitroblue tetrazolium-reducing activity and expressing CD11b but not CD14 and CD15. apicidin 0-8 integrin subunit alpha M Homo sapiens 103-108 14523559-11 2003 Chemically different types of HDAC inhibitors, such as TSA, apicidin, SAHA, M344 and n-butyrate induced remarkably similar responses in SIRT1-7 mRNA expression patterns. apicidin 60-68 sirtuin 1 Mus musculus 136-141 12393499-5 2003 Furthermore, analysis of different mitogen-activated protein (MAP) kinase signaling pathways revealed that p38 signaling was activated following apicidin treatment of cells and that inhibition of this pathway abolished the HbF-inducing effect of apicidin. apicidin 145-153 mitogen-activated protein kinase 14 Homo sapiens 107-110 12393499-5 2003 Furthermore, analysis of different mitogen-activated protein (MAP) kinase signaling pathways revealed that p38 signaling was activated following apicidin treatment of cells and that inhibition of this pathway abolished the HbF-inducing effect of apicidin. apicidin 246-254 mitogen-activated protein kinase 14 Homo sapiens 107-110 12393499-6 2003 Additionally, activation of the Agamma-globin promoter by apicidin could be inhibited by p38 inhibitor SB203580. apicidin 58-66 mitogen-activated protein kinase 14 Homo sapiens 89-92 12490313-5 2003 The expression of CD11b by apicidin was long lasting, while that by trichostatin A was transient. apicidin 27-35 integrin subunit alpha M Homo sapiens 18-23 12678732-4 2002 In the class of HDAC inhibitors, now included a short-chain fatty acids, such as 4-phenylbutyrate and valporic acid, hydroxamic acids, such as suberoylanilide hydroxamic acid (SAHA), pyroxamide, trichostatin A, oxamflatin and CHAPSs, cyclic tetrapeptides, such as trapoxin, apicidin and depsipeptide-also known as FK-228 or FR 901228, and benzamides, such as MS-275. apicidin 274-282 histone deacetylase 9 Homo sapiens 16-20 11698395-7 2002 The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis. apicidin 168-176 caspase 3 Homo sapiens 62-71 11698395-7 2002 The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis. apicidin 168-176 caspase 3 Homo sapiens 116-128 11698395-0 2002 Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. apicidin 0-8 Fas ligand Homo sapiens 69-79 11698395-8 2002 Consistent with these results, apicidin transiently increased the expressions of both Fas and Fas ligand. apicidin 31-39 Fas ligand Homo sapiens 94-104 11698395-1 2002 We previously reported that apicidin arrested human cancer cell growth through selective induction of p21(WAF1/Cip1). apicidin 28-36 cyclin dependent kinase inhibitor 1A Homo sapiens 102-105 11698395-1 2002 We previously reported that apicidin arrested human cancer cell growth through selective induction of p21(WAF1/Cip1). apicidin 28-36 cyclin dependent kinase inhibitor 1A Homo sapiens 106-110 11698395-9 2002 Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation. apicidin 144-152 Fas ligand Homo sapiens 69-79 11698395-1 2002 We previously reported that apicidin arrested human cancer cell growth through selective induction of p21(WAF1/Cip1). apicidin 28-36 cyclin dependent kinase inhibitor 1A Homo sapiens 111-115 11698395-9 2002 Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation. apicidin 144-152 BCL2 associated X, apoptosis regulator Homo sapiens 178-181 11698395-4 2002 In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 13-21 caspase 3 Homo sapiens 36-48 11698395-9 2002 Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation. apicidin 144-152 cytochrome c, somatic Homo sapiens 183-195 11698395-4 2002 In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 13-21 poly(ADP-ribose) polymerase 1 Homo sapiens 134-161 11698395-4 2002 In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 13-21 cyclin dependent kinase inhibitor 1A Homo sapiens 166-179 11698395-9 2002 Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation. apicidin 144-152 caspase 3 Homo sapiens 217-229 11698395-5 2002 Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 93-101 caspase 3 Homo sapiens 44-53 11698395-10 2002 Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3. apicidin 41-49 Fas ligand Homo sapiens 108-118 11698395-5 2002 Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 93-101 caspase 3 Homo sapiens 124-133 11698395-5 2002 Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 93-101 poly(ADP-ribose) polymerase 1 Homo sapiens 171-198 11698395-10 2002 Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3. apicidin 41-49 cytochrome c, somatic Homo sapiens 148-160 11698395-5 2002 Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1). apicidin 93-101 cyclin dependent kinase inhibitor 1A Homo sapiens 203-216 11698395-10 2002 Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3. apicidin 41-49 caspase 9 Homo sapiens 227-236 11698395-7 2002 The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis. apicidin 75-83 caspase 3 Homo sapiens 62-71 11698395-7 2002 The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis. apicidin 75-83 caspase 3 Homo sapiens 116-128 11698395-10 2002 Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3. apicidin 41-49 caspase 3 Homo sapiens 241-250 32971072-13 2020 In addition to Quisinostat, selective class I HDACs inhibitors, Apicidin and Entinostat, HDAC3 specific inhibitor RGFP966, as well as HDAC1 and HDAC3 siRNA prevent CaMKII overexpression induced cardiac myocyte hypertrophy. apicidin 64-72 calcium/calmodulin-dependent protein kinase II, beta Mus musculus 164-170 11551946-0 2001 Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1). apicidin 94-102 cyclin dependent kinase inhibitor 1A Homo sapiens 14-17 11551946-0 2001 Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1). apicidin 94-102 cyclin dependent kinase inhibitor 1A Homo sapiens 18-22 11551946-0 2001 Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1). apicidin 94-102 cyclin dependent kinase inhibitor 1A Homo sapiens 23-27 11551946-1 2001 In this study, we determined the molecular mechanisms by which apicidin induced the p21(WAF1/Cip1) gene expression in HeLa cells. apicidin 63-71 cyclin dependent kinase inhibitor 1A Homo sapiens 84-87 11551946-1 2001 In this study, we determined the molecular mechanisms by which apicidin induced the p21(WAF1/Cip1) gene expression in HeLa cells. apicidin 63-71 cyclin dependent kinase inhibitor 1A Homo sapiens 88-92 11551946-1 2001 In this study, we determined the molecular mechanisms by which apicidin induced the p21(WAF1/Cip1) gene expression in HeLa cells. apicidin 63-71 cyclin dependent kinase inhibitor 1A Homo sapiens 93-97 11551946-2 2001 Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 17-20 11551946-2 2001 Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 21-25 11551946-2 2001 Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 26-30 11551946-2 2001 Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 100-103 11551946-2 2001 Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 104-108 11551946-2 2001 Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 109-113 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 77-85 cyclin dependent kinase inhibitor 1A Homo sapiens 50-53 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 77-85 cyclin dependent kinase inhibitor 1A Homo sapiens 54-58 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 77-85 cyclin dependent kinase inhibitor 1A Homo sapiens 59-63 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 77-85 protein kinase C epsilon Homo sapiens 134-144 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 cyclin dependent kinase inhibitor 1A Homo sapiens 50-53 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 cyclin dependent kinase inhibitor 1A Homo sapiens 54-58 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 cyclin dependent kinase inhibitor 1A Homo sapiens 59-63 11085529-0 2000 Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 106-110 11085529-0 2000 Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. apicidin 0-8 gelsolin Homo sapiens 115-123 11085529-5 2000 In addition, apicidin induced selective changes in the expression of p21WAF1/Cip1 and gelsolin, which control the cell cycle and cell morphology, respectively. apicidin 13-21 cyclin dependent kinase inhibitor 1A Homo sapiens 77-81 11085529-5 2000 In addition, apicidin induced selective changes in the expression of p21WAF1/Cip1 and gelsolin, which control the cell cycle and cell morphology, respectively. apicidin 13-21 gelsolin Homo sapiens 86-94 11085529-7 2000 The effects of apicidin on cell morphology, expression of gelsolin, and HDAC1 activity in vivo and in vitro appeared to be irreversible, because withdrawal of apicidin did not reverse those effects, whereas the induction of p21WAF1/Cip1 by apicidin was reversible. apicidin 15-23 gelsolin Homo sapiens 58-66 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 protein kinase C epsilon Homo sapiens 134-144 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 protein kinase C epsilon Homo sapiens 134-137 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 cyclin dependent kinase inhibitor 1A Homo sapiens 310-313 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 cyclin dependent kinase inhibitor 1A Homo sapiens 314-318 11551946-4 2001 Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin. apicidin 87-95 cyclin dependent kinase inhibitor 1A Homo sapiens 319-323 11237739-0 2001 Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor. apicidin 48-56 cyclin dependent kinase inhibitor 1A Homo sapiens 30-43 11237739-2 2001 In this study, we show apicidin induces transcriptional activation of p21(WAF1/CIP1) (p21) in human prostate carcinoma cells. apicidin 23-31 cyclin dependent kinase inhibitor 1A Homo sapiens 70-83 11237739-2 2001 In this study, we show apicidin induces transcriptional activation of p21(WAF1/CIP1) (p21) in human prostate carcinoma cells. apicidin 23-31 cyclin dependent kinase inhibitor 1A Homo sapiens 70-73 11237739-3 2001 Apicidin induces expression of p21 protein and mRNA and activation of p21 promoter-luciferase reporter constructs. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 31-34 11237739-3 2001 Apicidin induces expression of p21 protein and mRNA and activation of p21 promoter-luciferase reporter constructs. apicidin 0-8 cyclin dependent kinase inhibitor 1A Homo sapiens 70-73 11237739-5 2001 Chromatin immunoprecipitation shows p21 promoter DNA is associated with hyperacetylated histones H3 and H4 after treatment with apicidin. apicidin 128-136 cyclin dependent kinase inhibitor 1A Homo sapiens 36-39 11237739-6 2001 Therefore, the data here demonstrate that apicidin activates p21 transcription associated with the acetylation of histones H3 and H4. apicidin 42-50 cyclin dependent kinase inhibitor 1A Homo sapiens 61-64 11085529-7 2000 The effects of apicidin on cell morphology, expression of gelsolin, and HDAC1 activity in vivo and in vitro appeared to be irreversible, because withdrawal of apicidin did not reverse those effects, whereas the induction of p21WAF1/Cip1 by apicidin was reversible. apicidin 15-23 histone deacetylase 1 Homo sapiens 72-77 11085529-7 2000 The effects of apicidin on cell morphology, expression of gelsolin, and HDAC1 activity in vivo and in vitro appeared to be irreversible, because withdrawal of apicidin did not reverse those effects, whereas the induction of p21WAF1/Cip1 by apicidin was reversible. apicidin 15-23 cyclin dependent kinase inhibitor 1A Homo sapiens 232-236 10893438-0 2000 Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype. apicidin 0-8 histone deacetylase 9 Homo sapiens 26-45 10893438-2 2000 In the present study, we have examined the anti-invasive effect of apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amin o-8-oxodecanoyl)], a fungal metabolite that was identified as an antiprotozoal agent known to inhibit parasite histone deacetylase (HDAC). apicidin 67-75 histone deacetylase 9 Homo sapiens 258-277 10893438-2 2000 In the present study, we have examined the anti-invasive effect of apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amin o-8-oxodecanoyl)], a fungal metabolite that was identified as an antiprotozoal agent known to inhibit parasite histone deacetylase (HDAC). apicidin 67-75 histone deacetylase 9 Homo sapiens 279-283 10893438-3 2000 We show that apicidin significantly inhibits H-ras-induced invasive phenotype of MCF10A human breast epithelial cells in parallel with a specific downregulation of matrix metalloproteinase (MMP)-2, but not MMP-9. apicidin 13-21 matrix metallopeptidase 2 Homo sapiens 164-196 10893438-4 2000 We also show that apicidin induces a morphological reversal and growth inhibition of H-ras MCF10A cells similar to that induced by other HDAC inhibitors. apicidin 18-26 histone deacetylase 9 Homo sapiens 137-141 33459431-0 2021 Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway. apicidin 59-67 calmodulin 1 Homo sapiens 0-10 33459431-0 2021 Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway. apicidin 59-67 mitogen-activated protein kinase 3 Homo sapiens 114-120 33459431-0 2021 Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway. apicidin 59-67 cAMP responsive element binding protein 1 Homo sapiens 121-125 33459431-0 2021 Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway. apicidin 59-67 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 126-131 33459431-5 2021 Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells. apicidin 107-115 calmodulin 1 Homo sapiens 24-27 33459431-5 2021 Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells. apicidin 107-115 cAMP responsive element binding protein 1 Homo sapiens 78-82 33459431-5 2021 Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells. apicidin 107-115 mitogen-activated protein kinase 3 Homo sapiens 86-92 33459431-5 2021 Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells. apicidin 107-115 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 98-103 33459431-7 2021 Our finding emphasizes an essential role of CaM/CaMKs in augmentation of the survival capability of apicidin-persistent liver cancer cells and suggests that CaM inhibition significantly attenuates CaM-induced tumor growth and abrogates antiapoptotic function and also offers a promising therapeutic target for cancer treatment. apicidin 100-108 calmodulin 1 Homo sapiens 44-47 33459431-7 2021 Our finding emphasizes an essential role of CaM/CaMKs in augmentation of the survival capability of apicidin-persistent liver cancer cells and suggests that CaM inhibition significantly attenuates CaM-induced tumor growth and abrogates antiapoptotic function and also offers a promising therapeutic target for cancer treatment. apicidin 100-108 calmodulin 1 Homo sapiens 48-51 33459431-7 2021 Our finding emphasizes an essential role of CaM/CaMKs in augmentation of the survival capability of apicidin-persistent liver cancer cells and suggests that CaM inhibition significantly attenuates CaM-induced tumor growth and abrogates antiapoptotic function and also offers a promising therapeutic target for cancer treatment. apicidin 100-108 calmodulin 1 Homo sapiens 48-51 31624245-6 2019 By systematically screening the compound perturbagens, the gene expression levels of MTHFD2 and PAICS were specifically suppressed by anisomycin and apicidin across cell lines, and our co-treatment results also displayed synergistic inhibition of MNA neuroblastoma cell proliferation. apicidin 149-157 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Homo sapiens 85-91 32998768-6 2020 RESULTS: HDAC inhibitors including suberoylanilide hydroxamic acid (SAHA), trichostatin, and apicidin, induce expression of PLD2 in a transcriptional level. apicidin 93-101 phospholipase D2 Homo sapiens 124-128 32107550-4 2020 Either genetic loss-of-function of HDAC3 or nanomolar concentrations of HDAC inhibitor apicidin lead to downregulation of Notch target genes accompanied by a local reduction of histone acetylation. apicidin 87-95 notch receptor 1 Homo sapiens 122-127 31673102-6 2019 RESULTS: We observed IL-8 release from cancer cells in response to histone deacetylase inhibitor, apicidin (Api), and non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase, thapsigargin (TG). apicidin 98-106 chemokine (C-X-C motif) ligand 15 Mus musculus 21-25 31673102-6 2019 RESULTS: We observed IL-8 release from cancer cells in response to histone deacetylase inhibitor, apicidin (Api), and non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase, thapsigargin (TG). apicidin 108-111 chemokine (C-X-C motif) ligand 15 Mus musculus 21-25 31673102-9 2019 Increased apoptosis was associated with decreased IL-8 expression in response to combined treatment of TG and Api. apicidin 110-113 chemokine (C-X-C motif) ligand 15 Mus musculus 50-54 31673102-10 2019 TG and Api combination induced caspase-8 and caspase-9 dependent apoptosis. apicidin 7-10 caspase 8 Mus musculus 31-40 31673102-10 2019 TG and Api combination induced caspase-8 and caspase-9 dependent apoptosis. apicidin 7-10 caspase 9 Mus musculus 45-54 31624245-6 2019 By systematically screening the compound perturbagens, the gene expression levels of MTHFD2 and PAICS were specifically suppressed by anisomycin and apicidin across cell lines, and our co-treatment results also displayed synergistic inhibition of MNA neuroblastoma cell proliferation. apicidin 149-157 phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase Homo sapiens 96-101 30897286-3 2019 In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg), on Mdr1 and Bcrp transporter expression in brain regions of adult male mice injected intraperitoneally daily for 7 days. apicidin 111-119 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 134-138 30963442-5 2019 Of the HDAC inhibitors profiled, valproic acid (VPA), apicidin, and suberoylanilide hydroxamic acid (SAHA) increased MDR1 mRNA and protein levels by 30-200%, which corresponded with reduced intracellular accumulation of the MDR1 substrate rhodamine 123. apicidin 54-62 ATP binding cassette subfamily B member 1 Homo sapiens 117-121 30963442-5 2019 Of the HDAC inhibitors profiled, valproic acid (VPA), apicidin, and suberoylanilide hydroxamic acid (SAHA) increased MDR1 mRNA and protein levels by 30-200%, which corresponded with reduced intracellular accumulation of the MDR1 substrate rhodamine 123. apicidin 54-62 ATP binding cassette subfamily B member 1 Homo sapiens 224-228 30897286-3 2019 In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg), on Mdr1 and Bcrp transporter expression in brain regions of adult male mice injected intraperitoneally daily for 7 days. apicidin 111-119 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 143-147 28951421-3 2017 We found that, in Jurkat T cells and in in vitro-differentiated Th17 cells, treatment with 2 HDAC inhibitors, butyrate and apicidin, led to the induction of the RORgammaT gene, which was associated with an increase in histone H4 acetylation near the RORgammaT proximal promoter. apicidin 123-131 histone deacetylase 9 Homo sapiens 93-97 30390184-0 2019 Correction to: Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cgamma1- and Ca2+-dependent pathway in mouse Neuro-2a neuroblastoma cells. apicidin 15-23 T cell receptor gamma, constant 1 Mus musculus 131-138 29749437-5 2018 Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis. apicidin 14-22 histone deacetylase 9 Homo sapiens 26-45 29749437-5 2018 Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis. apicidin 14-22 histone deacetylase 9 Homo sapiens 47-51 29749437-5 2018 Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis. apicidin 14-22 interleukin 7 receptor Homo sapiens 108-112 29749437-5 2018 Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis. apicidin 14-22 interleukin 7 receptor Homo sapiens 224-228 29749437-6 2018 Of note, apicidin induced the acetylation of Forkhead box-containing protein, O subfamily 1, which acts as a repressor at the IL7R promoter, accompanied with depleted active histone modifications based on chromatin immunoprecipitation assay. apicidin 9-17 interleukin 7 receptor Homo sapiens 126-130 30405794-0 2018 HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. apicidin 15-23 histone deacetylase 9 Homo sapiens 0-4 30405794-0 2018 HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. apicidin 15-23 histone deacetylase 8 Mus musculus 119-124 30405794-1 2018 Apicidin, a cyclic peptide histone deacetylase (HDAC) inhibitor, has been demonstrated to exhibit antitumor activity in a number of human cancer types. apicidin 0-8 histone deacetylase 9 Homo sapiens 27-46 30405794-1 2018 Apicidin, a cyclic peptide histone deacetylase (HDAC) inhibitor, has been demonstrated to exhibit antitumor activity in a number of human cancer types. apicidin 0-8 histone deacetylase 9 Homo sapiens 48-52 30405794-5 2018 Apicidin-induced cell growth inhibition and selectively reduced HDAC8 expression in AT-84 cells. apicidin 0-8 histone deacetylase 8 Mus musculus 64-69 30405794-9 2018 Overexpression of HDAC8 was observed in the nucleus and cytoplasm in tumor tissues and apicidin significantly inhibited the level of HDAC8 expression, compared with the vehicle group. apicidin 87-95 histone deacetylase 8 Mus musculus 18-23 30405794-9 2018 Overexpression of HDAC8 was observed in the nucleus and cytoplasm in tumor tissues and apicidin significantly inhibited the level of HDAC8 expression, compared with the vehicle group. apicidin 87-95 histone deacetylase 8 Mus musculus 133-138 30405794-10 2018 These results indicated that apicidin inhibited cell proliferation through HDAC8 inhibition in murine OSCC cells in vitro and in vivo. apicidin 29-37 histone deacetylase 8 Mus musculus 75-80 28796285-5 2017 In our study, we have identified that selective HDAC inhibition with inhibitors apicidin, MS-275 or MI-192, or specific knockdown of HDAC1 or 2 using siRNA, suppresses the expression of cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in BV-2 murine microglia activated with lipopolysaccharide (LPS). apicidin 80-88 interleukin 6 Mus musculus 196-209 28174211-6 2017 TSA, MGCD0103, and the cyclic peptide class I HDAC inhibitor, apicidin, exhibited a common ability to enhance histone acetylation, and all potently blocked cardiac fibroblast cell cycle progression. apicidin 62-70 histone deacetylase 9 Homo sapiens 46-50 28498815-4 2017 Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI). apicidin 22-30 GATA binding protein 4 Mus musculus 131-136 28498815-4 2017 Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI). apicidin 22-30 NK2 homeobox 5 Mus musculus 138-144 28498815-4 2017 Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI). apicidin 22-30 troponin I, cardiac 3 Mus musculus 150-168 28498815-4 2017 Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI). apicidin 22-30 troponin I, cardiac 3 Mus musculus 170-174 28498815-6 2017 Furthermore apicidin treatment or YAP knockdown downregulated miR-130a expression followed by induction of cardiac markers in MSC. apicidin 12-20 microRNA 130a Mus musculus 62-70 28498815-9 2017 Our results suggest that suppression of YAP/miR-130a shifts MSC cell fate toward cardiac lineage and identify apicidin as a potential pharmacological target for therapeutic development. apicidin 110-118 yes-associated protein 1 Mus musculus 40-43 28498815-9 2017 Our results suggest that suppression of YAP/miR-130a shifts MSC cell fate toward cardiac lineage and identify apicidin as a potential pharmacological target for therapeutic development. apicidin 110-118 microRNA 130a Mus musculus 44-52 28003340-0 2017 Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms. apicidin 30-38 ADAM metallopeptidase domain 10 Homo sapiens 83-89 28003340-0 2017 Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms. apicidin 30-38 upstream transcription factor 1 Homo sapiens 119-123 28003340-3 2017 By using high-throughput screening that targeted ADAM10, we determined that apicidin-an inhibitor of HDACs (histone deacetylases)-significantly increased mRNA and protein levels of ADAM10 in SH-SY5Y cells. apicidin 76-84 ADAM metallopeptidase domain 10 Homo sapiens 49-55 28003340-3 2017 By using high-throughput screening that targeted ADAM10, we determined that apicidin-an inhibitor of HDACs (histone deacetylases)-significantly increased mRNA and protein levels of ADAM10 in SH-SY5Y cells. apicidin 76-84 ADAM metallopeptidase domain 10 Homo sapiens 181-187 28003340-7 2017 We further found that apicidin did not affect the phosphorylation of ERK or USF1; however, ERK inhibitor U0126 blocked the effect of apicidin on ADAM10. apicidin 133-141 mitogen-activated protein kinase 1 Homo sapiens 91-94 28003340-7 2017 We further found that apicidin did not affect the phosphorylation of ERK or USF1; however, ERK inhibitor U0126 blocked the effect of apicidin on ADAM10. apicidin 133-141 ADAM metallopeptidase domain 10 Homo sapiens 145-151 28003340-8 2017 Finally, apicidin increased the level of alpha-site C-terminal fragment from APP and reduced the production of beta-amyloid peptide 1-42. apicidin 9-17 amyloid beta precursor protein Homo sapiens 111-136 28003340-9 2017 Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role. apicidin 103-111 ADAM metallopeptidase domain 10 Homo sapiens 47-53 28003340-9 2017 Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role. apicidin 103-111 histone deacetylase 2 Homo sapiens 85-92 28003340-9 2017 Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role. apicidin 103-111 upstream transcription factor 1 Homo sapiens 116-120 28003340-9 2017 Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role. apicidin 103-111 mitogen-activated protein kinase 1 Homo sapiens 151-154 28003340-11 2017 Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms. apicidin 30-38 ADAM metallopeptidase domain 10 Homo sapiens 83-89 28003340-11 2017 Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms. apicidin 30-38 upstream transcription factor 1 Homo sapiens 119-123 28178760-2 2017 We found that HDAC7 expression was selectively reduced by HDAC inhibitor apicidin in salivary mucoepidermoid carcinoma (MEC) cells. apicidin 73-81 histone deacetylase 7 Homo sapiens 14-19 27106131-3 2016 Here we report the histone deacetylase inhibitor apicidin (APC) or ER stressor thapsigargin (TG) potentiate paclitaxel (TXL)-induced apoptosis in PCa cells and limit accumulation of cancer stem cells. apicidin 49-57 thioredoxin like 1 Homo sapiens 120-123 28425856-2 2017 Apicidin has also been reported to induce apotosis via Fas/Fas ligand. apicidin 0-8 Fas ligand Homo sapiens 59-69 28425856-10 2017 Furthermore, apicidin suppressed proliferation and invasion, and induced apoptosis via mitochondrial pathway in GLC-82 cells, including loss of DeltaPsim, release of cytochrome c from mitochondria, activation of caspase-9 and -3, and cleavage of poly-ADP-ribose polymerase. apicidin 13-21 cytochrome c, somatic Homo sapiens 166-178 28425856-10 2017 Furthermore, apicidin suppressed proliferation and invasion, and induced apoptosis via mitochondrial pathway in GLC-82 cells, including loss of DeltaPsim, release of cytochrome c from mitochondria, activation of caspase-9 and -3, and cleavage of poly-ADP-ribose polymerase. apicidin 13-21 caspase 9 Homo sapiens 212-228 28425856-10 2017 Furthermore, apicidin suppressed proliferation and invasion, and induced apoptosis via mitochondrial pathway in GLC-82 cells, including loss of DeltaPsim, release of cytochrome c from mitochondria, activation of caspase-9 and -3, and cleavage of poly-ADP-ribose polymerase. apicidin 13-21 poly(ADP-ribose) polymerase 1 Homo sapiens 246-272 25233056-5 2015 Induction of histone acetylation in VM-derived NPCs by either knockdown of HDAC7 or treatment with the HDAC inhibitor apicidin upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions, leading to the expression of DA neuron developmental genes and enhanced differentiation of DA neurons. apicidin 118-126 forkhead box A2 Homo sapiens 139-144 25921925-7 2015 Moreover, inhibition of HDACs with apicidin decreases neonatal hypoxia-induced global DNA methylation levels in lungs and specific cytosine methylation levels around the pulmonary IGF-1 promoter region. apicidin 35-43 insulin-like growth factor 1 Mus musculus 180-185 25921925-8 2015 Finally, HDAC inhibition with apicidin reduces chronic hypoxia-induced activation of IGF-1/pAKT signaling in lungs and attenuates right ventricular hypertrophy and pulmonary vascular remodeling. apicidin 30-38 insulin-like growth factor 1 Mus musculus 85-90 25647264-10 2015 These results suggested that apicidin is an attractive chemotherapeutic agent against salivary MEC and may be a good candidate for targeting IGF-1R for cancer therapies. apicidin 29-37 insulin like growth factor 1 receptor Homo sapiens 141-147 25647264-0 2015 Apicidin inhibits cell growth by downregulating IGF-1R in salivary mucoepidermoid carcinoma cells. apicidin 0-8 insulin like growth factor 1 receptor Homo sapiens 48-54 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 mitogen-activated protein kinase 1 Homo sapiens 60-97 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 mitogen-activated protein kinase 1 Homo sapiens 99-102 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 AKT serine/threonine kinase 1 Homo sapiens 108-111 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 mechanistic target of rapamycin kinase Homo sapiens 112-116 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 mitogen-activated protein kinase 8 Homo sapiens 145-170 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 mitogen-activated protein kinase 8 Homo sapiens 172-175 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 AKT serine/threonine kinase 1 Homo sapiens 242-245 25647264-8 2015 Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling. apicidin 0-8 mechanistic target of rapamycin kinase Homo sapiens 246-250 25619426-8 2015 Apicidin, a Hdac2- and 3-specific inhibitor, reduced the cellular toxicity, which suggests that the toxicity of phytanic acid depends on activation of the Hdac2 and 3 subtypes. apicidin 0-8 histone deacetylase 2 Mus musculus 12-17 25619426-8 2015 Apicidin, a Hdac2- and 3-specific inhibitor, reduced the cellular toxicity, which suggests that the toxicity of phytanic acid depends on activation of the Hdac2 and 3 subtypes. apicidin 0-8 histone deacetylase 2 Mus musculus 155-166 23990456-0 2014 Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation. apicidin 0-8 insulin like growth factor 1 receptor Homo sapiens 102-108 25316709-8 2015 We also found that global hyperacetylation generated by the nonspecific histone deacetylase HDAC inhibitor Apicidin induces monocyte differentiation. apicidin 107-115 histone deacetylase 9 Homo sapiens 92-96 24644298-8 2014 Although the passive diffusion potential of apicidin was high (98.01%) by the IAM assay, the in situ permeability was significantly enhanced by the presence of the P-glycoprotein (P-gp) inhibitor elacrider. apicidin 44-52 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 180-184 24644298-9 2014 These data suggest that the low bioavailability of apicidin was mainly attributed to the P-gp efflux consistent with the limited FX measured in vivo experiment. apicidin 51-59 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 89-93 25275019-0 2014 Apicidin sensitizes pancreatic cancer cells to gemcitabine by epigenetically regulating MUC4 expression. apicidin 0-8 mucin 4, cell surface associated Homo sapiens 88-92 25275019-7 2014 CONCLUSION: Apicidin appears to be a novel anti-proliferative agent against pancreatic cancer cells that may reverse chemoresistance by epigenetically regulating MUC4 expression. apicidin 12-20 mucin 4, cell surface associated Homo sapiens 162-166 23990456-0 2014 Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation. apicidin 0-8 AKT serine/threonine kinase 1 Homo sapiens 114-117 22926926-0 2012 Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cgamma1- and Ca(2+)-dependent pathway in mouse Neuro-2a neuroblastoma cells. apicidin 0-8 phospholipase C, gamma 1 Mus musculus 102-123 23340162-5 2013 trichostatin A, sodium butyrate, APHA compound 8 and apicidin, were tested in the human lymphoblastoid TK6 cell line-hosted GADD45a-GFP assay, which has high sensitivity and specificity in the detection of genotoxic carcinogens and in vivo genotoxicants. apicidin 53-61 growth arrest and DNA damage inducible alpha Homo sapiens 124-131 22818786-1 2012 The effect of inhibitors of histone deacetylase (HDAC) on Apicomplexa has been previously reported with the discovery of apicidin, a cyclic tetrapeptide having broad-spectrum antiparasitic activity. apicidin 121-129 histone deacetylase 9 Homo sapiens 49-53 22818786-10 2012 The lower IC(50) values of apicidin against apicomplexan parasites than those of mammalian cells point to HDAC as an excellent drug target. apicidin 27-35 histone deacetylase 9 Homo sapiens 106-110 24495179-0 2013 Activation of snail and EMT-like signaling via the IKKalphabeta/NF-kappaB pathway in Apicidin-resistant HA22T hepatocellular carcinoma cells. apicidin 85-93 snail family transcriptional repressor 1 Homo sapiens 14-19 24495179-3 2013 Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells. apicidin 0-8 catenin beta 1 Homo sapiens 75-87 24495179-3 2013 Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells. apicidin 0-8 matrix metallopeptidase 2 Homo sapiens 110-115 24495179-3 2013 Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells. apicidin 0-8 insulin like growth factor 1 receptor Homo sapiens 135-141 24495179-3 2013 Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells. apicidin 0-8 AKT serine/threonine kinase 1 Homo sapiens 147-150 23403953-6 2013 ID2 knockdown cells were more susceptible to histone deacethylase (HDAC) inhibitors including sodium butyrate (NaB), sodium 4-phenyl-butyrate, tricostatin A, suberoylanilide hydroxamic acid, MS-275, apicidin and HC-toxin. apicidin 199-207 inhibitor of DNA binding 2 Homo sapiens 0-3 24317053-0 2013 Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect. apicidin 0-8 catenin beta 1 Homo sapiens 83-95 24317053-0 2013 Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect. apicidin 0-8 matrix metallopeptidase 2 Homo sapiens 118-123 24317053-0 2013 Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect. apicidin 0-8 insulin like growth factor 1 receptor Homo sapiens 143-149 24317053-0 2013 Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect. apicidin 0-8 AKT serine/threonine kinase 1 Homo sapiens 155-158 24317053-4 2013 Thus, Wnt/beta-catenin pathway over-activation might be involved in metastatic enhancement of apicidin-resistant HA22T cell metastasis. apicidin 94-102 catenin beta 1 Homo sapiens 10-22 24317053-5 2013 Apicidin-resistant (AR) HA22T cells showed higher beta-catenin nuclear accumulation and significantly decreased GSK-3-beta protein level, in relation to parental cells. apicidin 0-8 catenin beta 1 Homo sapiens 50-62 24317053-5 2013 Apicidin-resistant (AR) HA22T cells showed higher beta-catenin nuclear accumulation and significantly decreased GSK-3-beta protein level, in relation to parental cells. apicidin 0-8 glycogen synthase kinase 3 beta Homo sapiens 112-122 22781396-0 2012 Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing. apicidin 31-39 histone deacetylase 4 Homo sapiens 99-120 22781396-4 2012 Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. apicidin 0-8 histone deacetylase 4 Homo sapiens 49-54 22781396-4 2012 Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. apicidin 0-8 reversion inducing cysteine rich protein with kazal motifs Homo sapiens 86-90 22781396-4 2012 Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. apicidin 0-8 histone deacetylase 4 Homo sapiens 118-123 22781396-5 2012 In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. apicidin 21-29 histone deacetylase 4 Homo sapiens 100-105 22781396-5 2012 In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. apicidin 21-29 matrix metallopeptidase 2 Homo sapiens 110-115 22781396-6 2012 Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4. apicidin 0-8 matrix metallopeptidase 2 Homo sapiens 136-141 22781396-6 2012 Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4. apicidin 0-8 histone deacetylase 4 Homo sapiens 179-184 22926926-3 2012 Apicidin induced apoptotic cell death and activation of caspase-12, -9, and -3. apicidin 0-8 caspase 12 Mus musculus 56-78 22926926-4 2012 Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha. apicidin 0-8 DNA-damage inducible transcript 3 Mus musculus 96-145 22926926-4 2012 Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha. apicidin 0-8 DNA-damage inducible transcript 3 Mus musculus 147-151 22926926-4 2012 Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha. apicidin 0-8 activating transcription factor 6 Mus musculus 166-204 22926926-5 2012 Inhibition of ER stress by CHOP knockdown or using the ER stress inhibitors, salubrinal and 4-phenylbutyric acid, reduced apicidin-induced cell death. apicidin 122-130 DNA-damage inducible transcript 3 Mus musculus 27-31 22926926-10 2012 Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress. apicidin 15-23 T cell receptor gamma, constant 1 Mus musculus 65-72 22926926-10 2012 Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress. apicidin 15-23 phospholipase C, gamma 1 Mus musculus 74-83 22926926-10 2012 Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress. apicidin 15-23 epidermal growth factor receptor Mus musculus 89-121 22926926-10 2012 Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress. apicidin 15-23 epidermal growth factor receptor Mus musculus 123-127 22926926-10 2012 Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress. apicidin 15-23 phospholipase C, gamma 1 Mus musculus 148-157 22926926-10 2012 Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress. apicidin 15-23 epidermal growth factor receptor Mus musculus 162-166 22926926-11 2012 Finally, apicidin-induced histone H3 hyperacetylation and reduction of histone deacetylase 2 mRNA expression were not affected by either a PLCgamma1 inhibitor, U73122, or the antioxidant, N-acetyl cysteine. apicidin 9-17 histone deacetylase 2 Mus musculus 71-92 22926926-11 2012 Finally, apicidin-induced histone H3 hyperacetylation and reduction of histone deacetylase 2 mRNA expression were not affected by either a PLCgamma1 inhibitor, U73122, or the antioxidant, N-acetyl cysteine. apicidin 9-17 phospholipase C, gamma 1 Mus musculus 139-148 22926926-12 2012 Taken together, the results suggest that apicidin induces apoptosis by ER stress and mitochondrial dysfunction via PLCgamma1 activation, Ca(2+) release, and reactive oxygen species accumulation in Neuro-2a neuroblastoma cells. apicidin 41-49 phospholipase C, gamma 1 Mus musculus 115-124 23019417-0 2012 Apicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast cancer cells. apicidin 0-8 CCCTC-binding factor like Homo sapiens 52-57 23019417-0 2012 Apicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast cancer cells. apicidin 0-8 high mobility group box 1 Homo sapiens 73-78 23019417-5 2012 In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation. apicidin 13-21 BCL2 associated X, apoptosis regulator Homo sapiens 114-117 23019417-5 2012 In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation. apicidin 13-21 BCL2 apoptosis regulator Homo sapiens 118-123 23019417-5 2012 In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation. apicidin 13-21 caspase 8 Homo sapiens 134-143