PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33459431-0	2021	Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway.	apicidin	59-67	calmodulin 1	Homo sapiens	0-10
33459431-0	2021	Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway.	apicidin	59-67	mitogen-activated protein kinase 3	Homo sapiens	114-120
33459431-0	2021	Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway.	apicidin	59-67	cAMP responsive element binding protein 1	Homo sapiens	121-125
33459431-0	2021	Calmodulin/CaMKII-gamma mediates prosurvival capability in apicidin-persistent hepatocellular carcinoma cells via ERK1/2/CREB/c-fos signaling pathway.	apicidin	59-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	126-131
33459431-5	2021	Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells.	apicidin	107-115	calmodulin 1	Homo sapiens	24-27
33459431-5	2021	Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells.	apicidin	107-115	cAMP responsive element binding protein 1	Homo sapiens	78-82
33459431-5	2021	Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells.	apicidin	107-115	mitogen-activated protein kinase 3	Homo sapiens	86-92
33459431-5	2021	Furthermore, a specific CaM inhibitor trifluoperazine reduced the levels of p-CREB, p-ERK1/2, and c-fos in apicidin-persistent HA22T cells than in parental HA22T cells.	apicidin	107-115	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-103
33459431-7	2021	Our finding emphasizes an essential role of CaM/CaMKs in augmentation of the survival capability of apicidin-persistent liver cancer cells and suggests that CaM inhibition significantly attenuates CaM-induced tumor growth and abrogates antiapoptotic function and also offers a promising therapeutic target for cancer treatment.	apicidin	100-108	calmodulin 1	Homo sapiens	44-47
33459431-7	2021	Our finding emphasizes an essential role of CaM/CaMKs in augmentation of the survival capability of apicidin-persistent liver cancer cells and suggests that CaM inhibition significantly attenuates CaM-induced tumor growth and abrogates antiapoptotic function and also offers a promising therapeutic target for cancer treatment.	apicidin	100-108	calmodulin 1	Homo sapiens	48-51
33459431-7	2021	Our finding emphasizes an essential role of CaM/CaMKs in augmentation of the survival capability of apicidin-persistent liver cancer cells and suggests that CaM inhibition significantly attenuates CaM-induced tumor growth and abrogates antiapoptotic function and also offers a promising therapeutic target for cancer treatment.	apicidin	100-108	calmodulin 1	Homo sapiens	48-51
30963442-5	2019	Of the HDAC inhibitors profiled, valproic acid (VPA), apicidin, and suberoylanilide hydroxamic acid (SAHA) increased MDR1 mRNA and protein levels by 30-200%, which corresponded with reduced intracellular accumulation of the MDR1 substrate rhodamine 123.	apicidin	54-62	ATP binding cassette subfamily B member 1	Homo sapiens	117-121
31673102-6	2019	RESULTS: We observed IL-8 release from cancer cells in response to histone deacetylase inhibitor, apicidin (Api), and non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase, thapsigargin (TG).	apicidin	98-106	chemokine (C-X-C motif) ligand 15	Mus musculus	21-25
31673102-6	2019	RESULTS: We observed IL-8 release from cancer cells in response to histone deacetylase inhibitor, apicidin (Api), and non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase, thapsigargin (TG).	apicidin	108-111	chemokine (C-X-C motif) ligand 15	Mus musculus	21-25
31673102-9	2019	Increased apoptosis was associated with decreased IL-8 expression in response to combined treatment of TG and Api.	apicidin	110-113	chemokine (C-X-C motif) ligand 15	Mus musculus	50-54
31673102-10	2019	TG and Api combination induced caspase-8 and caspase-9 dependent apoptosis.	apicidin	7-10	caspase 8	Mus musculus	31-40
31673102-10	2019	TG and Api combination induced caspase-8 and caspase-9 dependent apoptosis.	apicidin	7-10	caspase 9	Mus musculus	45-54
32971072-13	2020	In addition to Quisinostat, selective class I HDACs inhibitors, Apicidin and Entinostat, HDAC3 specific inhibitor RGFP966, as well as HDAC1 and HDAC3 siRNA prevent CaMKII overexpression induced cardiac myocyte hypertrophy.	apicidin	64-72	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	164-170
32998768-6	2020	RESULTS: HDAC inhibitors including suberoylanilide hydroxamic acid (SAHA), trichostatin, and apicidin, induce expression of PLD2 in a transcriptional level.	apicidin	93-101	phospholipase D2	Homo sapiens	124-128
32107550-4	2020	Either genetic loss-of-function of HDAC3 or nanomolar concentrations of HDAC inhibitor apicidin lead to downregulation of Notch target genes accompanied by a local reduction of histone acetylation.	apicidin	87-95	notch receptor 1	Homo sapiens	122-127
31624245-6	2019	By systematically screening the compound perturbagens, the gene expression levels of MTHFD2 and PAICS were specifically suppressed by anisomycin and apicidin across cell lines, and our co-treatment results also displayed synergistic inhibition of MNA neuroblastoma cell proliferation.	apicidin	149-157	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	Homo sapiens	85-91
31624245-6	2019	By systematically screening the compound perturbagens, the gene expression levels of MTHFD2 and PAICS were specifically suppressed by anisomycin and apicidin across cell lines, and our co-treatment results also displayed synergistic inhibition of MNA neuroblastoma cell proliferation.	apicidin	149-157	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Homo sapiens	96-101
30963442-5	2019	Of the HDAC inhibitors profiled, valproic acid (VPA), apicidin, and suberoylanilide hydroxamic acid (SAHA) increased MDR1 mRNA and protein levels by 30-200%, which corresponded with reduced intracellular accumulation of the MDR1 substrate rhodamine 123.	apicidin	54-62	ATP binding cassette subfamily B member 1	Homo sapiens	224-228
30897286-3	2019	In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg), on Mdr1 and Bcrp transporter expression in brain regions of adult male mice injected intraperitoneally daily for 7 days.	apicidin	111-119	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	134-138
30897286-3	2019	In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg), on Mdr1 and Bcrp transporter expression in brain regions of adult male mice injected intraperitoneally daily for 7 days.	apicidin	111-119	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	143-147
30390184-0	2019	Correction to: Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cgamma1- and Ca2+-dependent pathway in mouse Neuro-2a neuroblastoma cells.	apicidin	15-23	T cell receptor gamma, constant 1	Mus musculus	131-138
29749437-5	2018	Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis.	apicidin	14-22	histone deacetylase 9	Homo sapiens	26-45
30405794-0	2018	HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression.	apicidin	15-23	histone deacetylase 9	Homo sapiens	0-4
30405794-0	2018	HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression.	apicidin	15-23	histone deacetylase 8	Mus musculus	119-124
30405794-1	2018	Apicidin, a cyclic peptide histone deacetylase (HDAC) inhibitor, has been demonstrated to exhibit antitumor activity in a number of human cancer types.	apicidin	0-8	histone deacetylase 9	Homo sapiens	27-46
30405794-1	2018	Apicidin, a cyclic peptide histone deacetylase (HDAC) inhibitor, has been demonstrated to exhibit antitumor activity in a number of human cancer types.	apicidin	0-8	histone deacetylase 9	Homo sapiens	48-52
30405794-5	2018	Apicidin-induced cell growth inhibition and selectively reduced HDAC8 expression in AT-84 cells.	apicidin	0-8	histone deacetylase 8	Mus musculus	64-69
30405794-9	2018	Overexpression of HDAC8 was observed in the nucleus and cytoplasm in tumor tissues and apicidin significantly inhibited the level of HDAC8 expression, compared with the vehicle group.	apicidin	87-95	histone deacetylase 8	Mus musculus	18-23
30405794-9	2018	Overexpression of HDAC8 was observed in the nucleus and cytoplasm in tumor tissues and apicidin significantly inhibited the level of HDAC8 expression, compared with the vehicle group.	apicidin	87-95	histone deacetylase 8	Mus musculus	133-138
30405794-10	2018	These results indicated that apicidin inhibited cell proliferation through HDAC8 inhibition in murine OSCC cells in vitro and in vivo.	apicidin	29-37	histone deacetylase 8	Mus musculus	75-80
29749437-5	2018	Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis.	apicidin	14-22	histone deacetylase 9	Homo sapiens	47-51
29749437-5	2018	Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis.	apicidin	14-22	interleukin 7 receptor	Homo sapiens	108-112
29749437-5	2018	Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis.	apicidin	14-22	interleukin 7 receptor	Homo sapiens	224-228
29749437-6	2018	Of note, apicidin induced the acetylation of Forkhead box-containing protein, O subfamily 1, which acts as a repressor at the IL7R promoter, accompanied with depleted active histone modifications based on chromatin immunoprecipitation assay.	apicidin	9-17	interleukin 7 receptor	Homo sapiens	126-130
28178760-2	2017	We found that HDAC7 expression was selectively reduced by HDAC inhibitor apicidin in salivary mucoepidermoid carcinoma (MEC) cells.	apicidin	73-81	histone deacetylase 7	Homo sapiens	14-19
28003340-0	2017	Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms.	apicidin	30-38	ADAM metallopeptidase domain 10	Homo sapiens	83-89
28003340-0	2017	Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms.	apicidin	30-38	upstream transcription factor 1	Homo sapiens	119-123
28003340-3	2017	By using high-throughput screening that targeted ADAM10, we determined that apicidin-an inhibitor of HDACs (histone deacetylases)-significantly increased mRNA and protein levels of ADAM10 in SH-SY5Y cells.	apicidin	76-84	ADAM metallopeptidase domain 10	Homo sapiens	49-55
28003340-3	2017	By using high-throughput screening that targeted ADAM10, we determined that apicidin-an inhibitor of HDACs (histone deacetylases)-significantly increased mRNA and protein levels of ADAM10 in SH-SY5Y cells.	apicidin	76-84	ADAM metallopeptidase domain 10	Homo sapiens	181-187
28003340-7	2017	We further found that apicidin did not affect the phosphorylation of ERK or USF1; however, ERK inhibitor U0126 blocked the effect of apicidin on ADAM10.	apicidin	133-141	mitogen-activated protein kinase 1	Homo sapiens	91-94
28003340-7	2017	We further found that apicidin did not affect the phosphorylation of ERK or USF1; however, ERK inhibitor U0126 blocked the effect of apicidin on ADAM10.	apicidin	133-141	ADAM metallopeptidase domain 10	Homo sapiens	145-151
28003340-8	2017	Finally, apicidin increased the level of alpha-site C-terminal fragment from APP and reduced the production of beta-amyloid peptide 1-42.	apicidin	9-17	amyloid beta precursor protein	Homo sapiens	111-136
28003340-9	2017	Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role.	apicidin	103-111	ADAM metallopeptidase domain 10	Homo sapiens	47-53
28003340-9	2017	Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role.	apicidin	103-111	histone deacetylase 2	Homo sapiens	85-92
28003340-9	2017	Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role.	apicidin	103-111	upstream transcription factor 1	Homo sapiens	116-120
28003340-9	2017	Collectively, our study provides evidence that ADAM10 expression can be regulated by HDAC2/3 inhibitor apicidin via USF1-dependent mechanisms in which ERK signaling plays an important role.	apicidin	103-111	mitogen-activated protein kinase 1	Homo sapiens	151-154
28003340-11	2017	Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms.	apicidin	30-38	ADAM metallopeptidase domain 10	Homo sapiens	83-89
28003340-11	2017	Histone deacetylase inhibitor apicidin increases expression of the alpha-secretase ADAM10 through transcription factor USF1-mediated mechanisms.	apicidin	30-38	upstream transcription factor 1	Homo sapiens	119-123
28951421-3	2017	We found that, in Jurkat T cells and in in vitro-differentiated Th17 cells, treatment with 2 HDAC inhibitors, butyrate and apicidin, led to the induction of the RORgammaT gene, which was associated with an increase in histone H4 acetylation near the RORgammaT proximal promoter.	apicidin	123-131	histone deacetylase 9	Homo sapiens	93-97
28796285-5	2017	In our study, we have identified that selective HDAC inhibition with inhibitors apicidin, MS-275 or MI-192, or specific knockdown of HDAC1 or 2 using siRNA, suppresses the expression of cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) in BV-2 murine microglia activated with lipopolysaccharide (LPS).	apicidin	80-88	interleukin 6	Mus musculus	196-209
28498815-4	2017	Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI).	apicidin	22-30	GATA binding protein 4	Mus musculus	131-136
28498815-4	2017	Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI).	apicidin	22-30	NK2 homeobox 5	Mus musculus	138-144
28498815-4	2017	Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI).	apicidin	22-30	troponin I, cardiac 3	Mus musculus	150-168
28498815-4	2017	Treatment of MSC with apicidin, a histone deacetylase inhibitor, dramatically increased the expressions of cardiac markers such as GATA4, Nkx2.5, and cardiac troponin I (cTnI).	apicidin	22-30	troponin I, cardiac 3	Mus musculus	170-174
28498815-6	2017	Furthermore apicidin treatment or YAP knockdown downregulated miR-130a expression followed by induction of cardiac markers in MSC.	apicidin	12-20	microRNA 130a	Mus musculus	62-70
28498815-9	2017	Our results suggest that suppression of YAP/miR-130a shifts MSC cell fate toward cardiac lineage and identify apicidin as a potential pharmacological target for therapeutic development.	apicidin	110-118	yes-associated protein 1	Mus musculus	40-43
28498815-9	2017	Our results suggest that suppression of YAP/miR-130a shifts MSC cell fate toward cardiac lineage and identify apicidin as a potential pharmacological target for therapeutic development.	apicidin	110-118	microRNA 130a	Mus musculus	44-52
28174211-6	2017	TSA, MGCD0103, and the cyclic peptide class I HDAC inhibitor, apicidin, exhibited a common ability to enhance histone acetylation, and all potently blocked cardiac fibroblast cell cycle progression.	apicidin	62-70	histone deacetylase 9	Homo sapiens	46-50
28425856-2	2017	Apicidin has also been reported to induce apotosis via Fas/Fas ligand.	apicidin	0-8	Fas ligand	Homo sapiens	59-69
28425856-10	2017	Furthermore, apicidin suppressed proliferation and invasion, and induced apoptosis via mitochondrial pathway in GLC-82 cells, including loss of DeltaPsim, release of cytochrome c from mitochondria, activation of caspase-9 and -3, and cleavage of poly-ADP-ribose polymerase.	apicidin	13-21	cytochrome c, somatic	Homo sapiens	166-178
28425856-10	2017	Furthermore, apicidin suppressed proliferation and invasion, and induced apoptosis via mitochondrial pathway in GLC-82 cells, including loss of DeltaPsim, release of cytochrome c from mitochondria, activation of caspase-9 and -3, and cleavage of poly-ADP-ribose polymerase.	apicidin	13-21	caspase 9	Homo sapiens	212-228
28425856-10	2017	Furthermore, apicidin suppressed proliferation and invasion, and induced apoptosis via mitochondrial pathway in GLC-82 cells, including loss of DeltaPsim, release of cytochrome c from mitochondria, activation of caspase-9 and -3, and cleavage of poly-ADP-ribose polymerase.	apicidin	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	246-272
27106131-3	2016	Here we report the histone deacetylase inhibitor apicidin (APC) or ER stressor thapsigargin (TG) potentiate paclitaxel (TXL)-induced apoptosis in PCa cells and limit accumulation of cancer stem cells.	apicidin	49-57	thioredoxin like 1	Homo sapiens	120-123
25921925-7	2015	Moreover, inhibition of HDACs with apicidin decreases neonatal hypoxia-induced global DNA methylation levels in lungs and specific cytosine methylation levels around the pulmonary IGF-1 promoter region.	apicidin	35-43	insulin-like growth factor 1	Mus musculus	180-185
25921925-8	2015	Finally, HDAC inhibition with apicidin reduces chronic hypoxia-induced activation of IGF-1/pAKT signaling in lungs and attenuates right ventricular hypertrophy and pulmonary vascular remodeling.	apicidin	30-38	insulin-like growth factor 1	Mus musculus	85-90
25316709-8	2015	We also found that global hyperacetylation generated by the nonspecific histone deacetylase HDAC inhibitor Apicidin induces monocyte differentiation.	apicidin	107-115	histone deacetylase 9	Homo sapiens	92-96
25647264-0	2015	Apicidin inhibits cell growth by downregulating IGF-1R in salivary mucoepidermoid carcinoma cells.	apicidin	0-8	insulin like growth factor 1 receptor	Homo sapiens	48-54
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	mitogen-activated protein kinase 1	Homo sapiens	60-97
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	mitogen-activated protein kinase 1	Homo sapiens	99-102
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	AKT serine/threonine kinase 1	Homo sapiens	108-111
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	112-116
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	mitogen-activated protein kinase 8	Homo sapiens	145-170
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	mitogen-activated protein kinase 8	Homo sapiens	172-175
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	AKT serine/threonine kinase 1	Homo sapiens	242-245
25647264-8	2015	Apicidin also induced apoptosis through the inactivation of extracellular signal-regulated kinase (ERK) and AKT/mTOR signaling and activation of c-Jun NH2-terminal kinase (JNK), whereas apicidin promoted autophagy through inactivation of the AKT/mTOR signaling.	apicidin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	246-250
25619426-8	2015	Apicidin, a Hdac2- and 3-specific inhibitor, reduced the cellular toxicity, which suggests that the toxicity of phytanic acid depends on activation of the Hdac2 and 3 subtypes.	apicidin	0-8	histone deacetylase 2	Mus musculus	12-17
25619426-8	2015	Apicidin, a Hdac2- and 3-specific inhibitor, reduced the cellular toxicity, which suggests that the toxicity of phytanic acid depends on activation of the Hdac2 and 3 subtypes.	apicidin	0-8	histone deacetylase 2	Mus musculus	155-166
25233056-5	2015	Induction of histone acetylation in VM-derived NPCs by either knockdown of HDAC7 or treatment with the HDAC inhibitor apicidin upregulates Foxa2 expression via hyperacetylation of H3 and a decrease in H3K27 trimethylation on the promoter regions, leading to the expression of DA neuron developmental genes and enhanced differentiation of DA neurons.	apicidin	118-126	forkhead box A2	Homo sapiens	139-144
25647264-10	2015	These results suggested that apicidin is an attractive chemotherapeutic agent against salivary MEC and may be a good candidate for targeting IGF-1R for cancer therapies.	apicidin	29-37	insulin like growth factor 1 receptor	Homo sapiens	141-147
23990456-0	2014	Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation.	apicidin	0-8	insulin like growth factor 1 receptor	Homo sapiens	102-108
25275019-0	2014	Apicidin sensitizes pancreatic cancer cells to gemcitabine by epigenetically regulating MUC4 expression.	apicidin	0-8	mucin 4, cell surface associated	Homo sapiens	88-92
25275019-7	2014	CONCLUSION: Apicidin appears to be a novel anti-proliferative agent against pancreatic cancer cells that may reverse chemoresistance by epigenetically regulating MUC4 expression.	apicidin	12-20	mucin 4, cell surface associated	Homo sapiens	162-166
24644298-8	2014	Although the passive diffusion potential of apicidin was high (98.01%) by the IAM assay, the in situ permeability was significantly enhanced by the presence of the P-glycoprotein (P-gp) inhibitor elacrider.	apicidin	44-52	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	180-184
24644298-9	2014	These data suggest that the low bioavailability of apicidin was mainly attributed to the P-gp efflux consistent with the limited FX measured in vivo experiment.	apicidin	51-59	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	89-93
23990456-0	2014	Apicidin-resistant HA22T hepatocellular carcinoma cells massively promote pro-survival capability via IGF-IR/PI3K/Akt signaling pathway activation.	apicidin	0-8	AKT serine/threonine kinase 1	Homo sapiens	114-117
22926926-0	2012	Apicidin induces endoplasmic reticulum stress- and mitochondrial dysfunction-associated apoptosis via phospholipase Cgamma1- and Ca(2+)-dependent pathway in mouse Neuro-2a neuroblastoma cells.	apicidin	0-8	phospholipase C, gamma 1	Mus musculus	102-123
24495179-0	2013	Activation of snail and EMT-like signaling via the IKKalphabeta/NF-kappaB pathway in Apicidin-resistant HA22T hepatocellular carcinoma cells.	apicidin	85-93	snail family transcriptional repressor 1	Homo sapiens	14-19
24495179-3	2013	Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells.	apicidin	0-8	catenin beta 1	Homo sapiens	75-87
24495179-3	2013	Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells.	apicidin	0-8	matrix metallopeptidase 2	Homo sapiens	110-115
24495179-3	2013	Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells.	apicidin	0-8	insulin like growth factor 1 receptor	Homo sapiens	135-141
24495179-3	2013	Apicidin-resistant (Apicidin- R) HA22T cells are known to activate the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway to enhance metastatic effects of cancer cells.	apicidin	0-8	AKT serine/threonine kinase 1	Homo sapiens	147-150
23340162-5	2013	trichostatin A, sodium butyrate, APHA compound 8 and apicidin, were tested in the human lymphoblastoid TK6 cell line-hosted GADD45a-GFP assay, which has high sensitivity and specificity in the detection of genotoxic carcinogens and in vivo genotoxicants.	apicidin	53-61	growth arrest and DNA damage inducible alpha	Homo sapiens	124-131
24317053-0	2013	Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect.	apicidin	0-8	catenin beta 1	Homo sapiens	83-95
24317053-0	2013	Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect.	apicidin	0-8	matrix metallopeptidase 2	Homo sapiens	118-123
24317053-0	2013	Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect.	apicidin	0-8	insulin like growth factor 1 receptor	Homo sapiens	143-149
24317053-0	2013	Apicidin-resistant HA22T hepatocellular carcinoma cells strongly activated the Wnt/beta-catenin signaling pathway and MMP-2 expression via the IGF-IR/PI3K/Akt signaling pathway enhancing cell metastatic effect.	apicidin	0-8	AKT serine/threonine kinase 1	Homo sapiens	155-158
24317053-4	2013	Thus, Wnt/beta-catenin pathway over-activation might be involved in metastatic enhancement of apicidin-resistant HA22T cell metastasis.	apicidin	94-102	catenin beta 1	Homo sapiens	10-22
24317053-5	2013	Apicidin-resistant (AR) HA22T cells showed higher beta-catenin nuclear accumulation and significantly decreased GSK-3-beta protein level, in relation to parental cells.	apicidin	0-8	catenin beta 1	Homo sapiens	50-62
24317053-5	2013	Apicidin-resistant (AR) HA22T cells showed higher beta-catenin nuclear accumulation and significantly decreased GSK-3-beta protein level, in relation to parental cells.	apicidin	0-8	glycogen synthase kinase 3 beta	Homo sapiens	112-122
22818786-1	2012	The effect of inhibitors of histone deacetylase (HDAC) on Apicomplexa has been previously reported with the discovery of apicidin, a cyclic tetrapeptide having broad-spectrum antiparasitic activity.	apicidin	121-129	histone deacetylase 9	Homo sapiens	49-53
22818786-10	2012	The lower IC(50) values of apicidin against apicomplexan parasites than those of mammalian cells point to HDAC as an excellent drug target.	apicidin	27-35	histone deacetylase 9	Homo sapiens	106-110
23403953-6	2013	ID2 knockdown cells were more susceptible to histone deacethylase (HDAC) inhibitors including sodium butyrate (NaB), sodium 4-phenyl-butyrate, tricostatin A, suberoylanilide hydroxamic acid, MS-275, apicidin and HC-toxin.	apicidin	199-207	inhibitor of DNA binding 2	Homo sapiens	0-3
22781396-0	2012	Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing.	apicidin	31-39	histone deacetylase 4	Homo sapiens	99-120
22781396-4	2012	Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4.	apicidin	0-8	histone deacetylase 4	Homo sapiens	49-54
22781396-4	2012	Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4.	apicidin	0-8	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	86-90
22781396-4	2012	Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4.	apicidin	0-8	histone deacetylase 4	Homo sapiens	118-123
22781396-5	2012	In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2.	apicidin	21-29	histone deacetylase 4	Homo sapiens	100-105
22781396-5	2012	In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2.	apicidin	21-29	matrix metallopeptidase 2	Homo sapiens	110-115
22781396-6	2012	Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4.	apicidin	0-8	matrix metallopeptidase 2	Homo sapiens	136-141
22781396-6	2012	Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4.	apicidin	0-8	histone deacetylase 4	Homo sapiens	179-184
22926926-3	2012	Apicidin induced apoptotic cell death and activation of caspase-12, -9, and -3.	apicidin	0-8	caspase 12	Mus musculus	56-78
22926926-4	2012	Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha.	apicidin	0-8	DNA-damage inducible transcript 3	Mus musculus	96-145
22926926-4	2012	Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha.	apicidin	0-8	DNA-damage inducible transcript 3	Mus musculus	147-151
22926926-4	2012	Apicidin induced expression of endoplasmic reticulum (ER) stress-associated proteins, including CCAAT/enhancer binding protein homologous protein (CHOP), cleavage of activating transcription factor 6alpha, and phosphorylation of eukaryotic initiation factor 2alpha.	apicidin	0-8	activating transcription factor 6	Mus musculus	166-204
22926926-5	2012	Inhibition of ER stress by CHOP knockdown or using the ER stress inhibitors, salubrinal and 4-phenylbutyric acid, reduced apicidin-induced cell death.	apicidin	122-130	DNA-damage inducible transcript 3	Mus musculus	27-31
22926926-10	2012	Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress.	apicidin	15-23	T cell receptor gamma, constant 1	Mus musculus	65-72
22926926-10	2012	Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress.	apicidin	15-23	phospholipase C, gamma 1	Mus musculus	74-83
22926926-10	2012	Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress.	apicidin	15-23	epidermal growth factor receptor	Mus musculus	89-121
22926926-10	2012	Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress.	apicidin	15-23	epidermal growth factor receptor	Mus musculus	123-127
22926926-10	2012	Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress.	apicidin	15-23	phospholipase C, gamma 1	Mus musculus	148-157
22926926-10	2012	Interestingly, apicidin induced phosphorylation of phospholipase Cgamma1 (PLCgamma1) and epidermal growth factor receptor (EGFR), and inhibition of PLCgamma1 and EGFR reduced cell death and ER stress.	apicidin	15-23	epidermal growth factor receptor	Mus musculus	162-166
22926926-11	2012	Finally, apicidin-induced histone H3 hyperacetylation and reduction of histone deacetylase 2 mRNA expression were not affected by either a PLCgamma1 inhibitor, U73122, or the antioxidant, N-acetyl cysteine.	apicidin	9-17	histone deacetylase 2	Mus musculus	71-92
22926926-11	2012	Finally, apicidin-induced histone H3 hyperacetylation and reduction of histone deacetylase 2 mRNA expression were not affected by either a PLCgamma1 inhibitor, U73122, or the antioxidant, N-acetyl cysteine.	apicidin	9-17	phospholipase C, gamma 1	Mus musculus	139-148
22926926-12	2012	Taken together, the results suggest that apicidin induces apoptosis by ER stress and mitochondrial dysfunction via PLCgamma1 activation, Ca(2+) release, and reactive oxygen species accumulation in Neuro-2a neuroblastoma cells.	apicidin	41-49	phospholipase C, gamma 1	Mus musculus	115-124
22903717-8	2012	Interestingly, the acetylation of a subset of the mitotic proteins can be further enhanced by treatment with apicidin, a small molecule inhibitor with specificity for HDAC3, suggesting that their acetylation may be regulated by HDAC3 in mitosis.	apicidin	109-117	histone deacetylase 3	Homo sapiens	167-172
23019417-0	2012	Apicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast cancer cells.	apicidin	0-8	CCCTC-binding factor like	Homo sapiens	52-57
23019417-0	2012	Apicidin and docetaxel combination treatment drives CTCFL expression and HMGB1 release acting as potential antitumor immune response inducers in metastatic breast cancer cells.	apicidin	0-8	high mobility group box 1	Homo sapiens	73-78
23019417-5	2012	In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation.	apicidin	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	114-117
23019417-5	2012	In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation.	apicidin	13-21	BCL2 apoptosis regulator	Homo sapiens	118-123
23019417-5	2012	In addition, apicidin and docetaxel co-treatment specifically stimulates apoptosis, characterized by an increased Bax/Bcl-2 ratio and caspase-8 activation.	apicidin	13-21	caspase 8	Homo sapiens	134-143
22903717-8	2012	Interestingly, the acetylation of a subset of the mitotic proteins can be further enhanced by treatment with apicidin, a small molecule inhibitor with specificity for HDAC3, suggesting that their acetylation may be regulated by HDAC3 in mitosis.	apicidin	109-117	histone deacetylase 3	Homo sapiens	228-233
22903717-9	2012	In this chapter, we describe the various techniques using NudC as an example of an acetylated protein that is sensitive to apicidin treatment in mitosis.	apicidin	123-131	nuclear distribution C, dynein complex regulator	Homo sapiens	58-62
20537879-5	2011	Apicidin sensitised towards CD95 also in the intact organ, i.e. in the isolated perfused mouse liver.	apicidin	0-8	Fas (TNF receptor superfamily member 6)	Mus musculus	28-32
22027828-4	2011	When endothelial cells were treated with the HDAC3 inhibitor, apicidin, or shRNA-HDAC3 knockdown, IFN-gamma-induced galectin-9 expression was abolished.	apicidin	62-70	interferon gamma	Homo sapiens	98-107
22027828-4	2011	When endothelial cells were treated with the HDAC3 inhibitor, apicidin, or shRNA-HDAC3 knockdown, IFN-gamma-induced galectin-9 expression was abolished.	apicidin	62-70	galectin 9	Homo sapiens	116-126
21455583-5	2011	In addition, apicidin, a histone deacetylase inhibitor, was shown to attenuate the invasion, migration and MMP-9 expression in MDA-MB-231 cells.	apicidin	13-21	matrix metallopeptidase 9	Homo sapiens	107-112
21086175-0	2011	Apicidin suppresses transcription of 17beta-hydroxysteroid dehydrogenase type 1 in endometrial adenocarcinoma cells.	apicidin	0-8	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	37-79
21086175-3	2011	ER(+) ISH, but not ER(-)02 ISH, cells were significantly susceptible to apicidin induced death, and we further used ER(-)ISH cells to study the effect of apicidin on cellular levels of HSD17B1 transcript and protein.	apicidin	154-162	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	185-192
21086175-6	2011	However, chromatin immunoprecipitation analysis revealed that apicidin significantly decreased occupation of the first exon of the HSD17B1 gene by Polymerase II.	apicidin	62-70	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	131-138
20888352-4	2011	VPA, SB, TSA, MS-275, and apicidin also upregulated levels of the neuroprotective heat shock protein 70 (HSP70) in rat astrocytes.	apicidin	26-34	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	82-103
20888352-4	2011	VPA, SB, TSA, MS-275, and apicidin also upregulated levels of the neuroprotective heat shock protein 70 (HSP70) in rat astrocytes.	apicidin	26-34	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	105-110
20181093-10	2010	Similar effects were seen with a structurally dissimilar HDAC inhibitor apicidin.	apicidin	72-80	histone deacetylase 9	Homo sapiens	57-61
20580868-3	2010	Non-toxic and functional doses of all HDACi but apicidin, similarly sensitized different leukemic T cell lines to TRAIL-induced apoptosis, while they showed no effect on the resistance of normal T lymphocytes.	apicidin	48-56	TNF superfamily member 10	Homo sapiens	114-119
20812760-9	2010	We further showed that acetylation of APC1 and NudC was enhanced by apicidin treatment, suggesting that their acetylation was regulated by histone deacetylase.	apicidin	68-76	solute carrier family 25 member 24	Homo sapiens	38-42
20812760-9	2010	We further showed that acetylation of APC1 and NudC was enhanced by apicidin treatment, suggesting that their acetylation was regulated by histone deacetylase.	apicidin	68-76	nuclear distribution C, dynein complex regulator	Homo sapiens	47-51
20470885-7	2010	Analysis of TGF-beta-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs.	apicidin	158-166	transforming growth factor, beta 1	Mus musculus	12-20
20470885-7	2010	Analysis of TGF-beta-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs.	apicidin	158-166	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	Mus musculus	29-35
20470885-7	2010	Analysis of TGF-beta-induced Adam12 and Timp-1 expression and ERK/PI3K signalling in the presence of semi-selective HDAC inhibitors valproic acid, MS-275 and apicidin implicated a role for class I HDACs.	apicidin	158-166	mitogen-activated protein kinase 1	Mus musculus	62-65
20527723-0	2010	Apicidin upregulates PHD2 prolyl hydroxylase gene expression in cervical cancer cells.	apicidin	0-8	egl-9 family hypoxia inducible factor 1	Homo sapiens	21-25
20527723-2	2010	We used HeLa, CaSki, C33A, and SiHa cervical cancer cells to show the effect of apicidin on cellular levels of PHD2 enzyme.	apicidin	80-88	egl-9 family hypoxia inducible factor 1	Homo sapiens	111-115
20527723-3	2010	Using reverse transcription, real-time quantitative PCR, and western blot analysis, we established that apicidin upregulates PHD2 transcript and protein levels in HeLa, CaSki, and C33A, but not in SiHa cervical cancer cells.	apicidin	104-112	egl-9 family hypoxia inducible factor 1	Homo sapiens	125-129
20527723-4	2010	Bisulfite sequencing showed that the increase in PHD2 expression was accompanied by demethylation ofCpG islands located in the first exon of the PHD2 gene.As decreased PHD2 expression supports tumor progression, our findings may validate the usefulness of apicidin as an anticancer drug.	apicidin	256-264	egl-9 family hypoxia inducible factor 1	Homo sapiens	49-53
20527723-4	2010	Bisulfite sequencing showed that the increase in PHD2 expression was accompanied by demethylation ofCpG islands located in the first exon of the PHD2 gene.As decreased PHD2 expression supports tumor progression, our findings may validate the usefulness of apicidin as an anticancer drug.	apicidin	256-264	egl-9 family hypoxia inducible factor 1	Homo sapiens	145-149
20527723-4	2010	Bisulfite sequencing showed that the increase in PHD2 expression was accompanied by demethylation ofCpG islands located in the first exon of the PHD2 gene.As decreased PHD2 expression supports tumor progression, our findings may validate the usefulness of apicidin as an anticancer drug.	apicidin	256-264	egl-9 family hypoxia inducible factor 1	Homo sapiens	145-149
19567677-4	2009	Down-regulation of the gene by either small interfering RNAs targeting Nanog or histone deacetylase inhibitor apicidin causes reversion of expression pattern of embryonic stem cell signature including Oct4, Sox2, and their target genes, leading to cell cycle arrest, inhibition of colony formation in soft agar, and induction of differentiation into all three germ layers.	apicidin	110-118	POU class 5 homeobox 1	Homo sapiens	201-205
19765194-5	2009	Other HDAC inhibitors--sodium butyrate, trichostatin A, and Class I HDAC-specific inhibitors MS-275 and apicidin, --all mimicked the ability of VPA to induce HSP70.	apicidin	104-112	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	158-163
18993024-0	2009	Apicidin decreases phospholipase C gamma-1 transcript and protein in Hut-78 T lymphoma cells.	apicidin	0-8	phospholipase C gamma 1	Homo sapiens	19-42
18993024-2	2009	We used Hut-78 T lymphoma cells to demonstrate the effect of apicidin on cellular levels of the PLCgamma1 molecule.	apicidin	61-69	phospholipase C gamma 1	Homo sapiens	96-105
18993024-5	2009	Moreover, we determined that apicidin reduces the half-life of PLCgamma1 mRNAs from approximately 2 to 4h.	apicidin	29-37	phospholipase C gamma 1	Homo sapiens	63-72
18993024-6	2009	Since PLCgamma1 is considered a key molecule in signal transduction in T cells, apicidin may be useful in the treatment of some autoimmune diseases in which autoreactive T cells occur.	apicidin	80-88	phospholipase C gamma 1	Homo sapiens	6-15
19567677-6	2009	Interestingly, embryonic carcinoma cells (NCCIT, NTERA2, and P19) exhibit a higher sensitivity to apicidin in down-regulation of Nanog compared with embryonic stem cells.	apicidin	98-106	cyclin dependent kinase inhibitor 2D	Homo sapiens	61-64
19567677-6	2009	Interestingly, embryonic carcinoma cells (NCCIT, NTERA2, and P19) exhibit a higher sensitivity to apicidin in down-regulation of Nanog compared with embryonic stem cells.	apicidin	98-106	Nanog homeobox	Homo sapiens	129-134
19956841-0	2010	Anti-tumor effect of apicidin on Ishikawa human endometrial cancer cells both in vitro and in vivo by blocking histone deacetylase 3 and 4.	apicidin	21-29	histone deacetylase 3	Homo sapiens	111-138
19956841-7	2010	Apicidin suppressed the tumor growth of transplanted Ishikawa cells, the expression of proliferative cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) in tumor xenograft model, respectively.	apicidin	0-8	proliferating cell nuclear antigen	Homo sapiens	123-127
19956841-7	2010	Apicidin suppressed the tumor growth of transplanted Ishikawa cells, the expression of proliferative cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) in tumor xenograft model, respectively.	apicidin	0-8	vascular endothelial growth factor A	Homo sapiens	133-167
19956841-7	2010	Apicidin suppressed the tumor growth of transplanted Ishikawa cells, the expression of proliferative cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF) in tumor xenograft model, respectively.	apicidin	0-8	vascular endothelial growth factor A	Homo sapiens	169-173
19956841-8	2010	The inhibitory effect of apicidin on tumor growth was mediated in part through the down-regulation of HDAC3 and HDAC4.	apicidin	25-33	histone deacetylase 3	Homo sapiens	102-107
19956841-8	2010	The inhibitory effect of apicidin on tumor growth was mediated in part through the down-regulation of HDAC3 and HDAC4.	apicidin	25-33	histone deacetylase 4	Homo sapiens	112-117
19956841-9	2010	We suggest that apicidin is an effective anti-tumor agent on human endometrial cancer cells, and acts by regulating cell proliferation and apoptosis through the down-regulation of HDAC3 and HDAC4.	apicidin	16-24	histone deacetylase 3	Homo sapiens	180-185
19956841-9	2010	We suggest that apicidin is an effective anti-tumor agent on human endometrial cancer cells, and acts by regulating cell proliferation and apoptosis through the down-regulation of HDAC3 and HDAC4.	apicidin	16-24	histone deacetylase 4	Homo sapiens	190-195
19567677-4	2009	Down-regulation of the gene by either small interfering RNAs targeting Nanog or histone deacetylase inhibitor apicidin causes reversion of expression pattern of embryonic stem cell signature including Oct4, Sox2, and their target genes, leading to cell cycle arrest, inhibition of colony formation in soft agar, and induction of differentiation into all three germ layers.	apicidin	110-118	SRY-box transcription factor 2	Homo sapiens	207-211
19407971-4	2009	Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized.	apicidin	154-162	transcription factor AP-2, alpha	Mus musculus	68-71
19268463-0	2009	Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells.	apicidin	17-25	TNF superfamily member 10	Homo sapiens	36-41
19268463-0	2009	Cotreatment with apicidin overcomes TRAIL resistance via inhibition of Bcr-Abl signaling pathway in K562 leukemia cells.	apicidin	17-25	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	71-78
19268463-3	2009	In this study, we investigated whether apicidin, a novel histone deacetylase inhibitor, could overcome the TRAIL resistance in CML-derived K562 cells.	apicidin	39-47	TNF superfamily member 10	Homo sapiens	107-112
19268463-4	2009	Compared to treatment with apicidin or TRAIL alone, cotreatment with apicidin and TRAIL-induced apoptosis synergistically in K562 cells.	apicidin	27-35	TNF superfamily member 10	Homo sapiens	82-87
19268463-4	2009	Compared to treatment with apicidin or TRAIL alone, cotreatment with apicidin and TRAIL-induced apoptosis synergistically in K562 cells.	apicidin	69-77	TNF superfamily member 10	Homo sapiens	39-44
19268463-6	2009	Treatment with apicidin resulted in down-regulation of Bcr-Abl and inhibition of its downstream target, PI3K/AKT-NF-kappaB pathway.	apicidin	15-23	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-62
19268463-7	2009	In addition, apicidin decreased the level of NF-kappaB-dependent Bcl-x(L), leading to caspase activation and Bid cleavage.	apicidin	13-21	BCL2 like 1	Homo sapiens	65-73
19268463-8	2009	These results suggest that apicidin may sensitize K562 cells to TRAIL-induced apoptosis through caspase-dependent mitochondrial pathway by regulating expression of Bcr-Abl and its related anti-apoptotic proteins.	apicidin	27-35	TNF superfamily member 10	Homo sapiens	64-69
19268463-8	2009	These results suggest that apicidin may sensitize K562 cells to TRAIL-induced apoptosis through caspase-dependent mitochondrial pathway by regulating expression of Bcr-Abl and its related anti-apoptotic proteins.	apicidin	27-35	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	164-171
19268463-9	2009	Therefore, the present study suggests that combination of apicidin and TRAIL may be an effective strategy for treating TRAIL-resistant Bcr-Abl expressing CML cells.	apicidin	58-66	TNF superfamily member 10	Homo sapiens	119-124
19268463-9	2009	Therefore, the present study suggests that combination of apicidin and TRAIL may be an effective strategy for treating TRAIL-resistant Bcr-Abl expressing CML cells.	apicidin	58-66	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	135-142
19376607-0	2009	Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo.	apicidin	19-27	sulfatase 1	Homo sapiens	47-58
19376607-4	2009	METHODS: We evaluated the effects of apicidin alone or combined with doxorubicin on apoptosis, caspase activity, and phosphorylation of Erk and Akt in SULF1-transfected Huh7 and Hep3B cells in vitro and in vivo.	apicidin	37-45	mitogen-activated protein kinase 1	Homo sapiens	136-139
19376607-4	2009	METHODS: We evaluated the effects of apicidin alone or combined with doxorubicin on apoptosis, caspase activity, and phosphorylation of Erk and Akt in SULF1-transfected Huh7 and Hep3B cells in vitro and in vivo.	apicidin	37-45	sulfatase 1	Homo sapiens	151-156
19376607-4	2009	METHODS: We evaluated the effects of apicidin alone or combined with doxorubicin on apoptosis, caspase activity, and phosphorylation of Erk and Akt in SULF1-transfected Huh7 and Hep3B cells in vitro and in vivo.	apicidin	37-45	MIR7-3 host gene	Homo sapiens	169-173
19376607-7	2009	Apicidin also decreased phosphorylation of both Erk and Akt.	apicidin	0-8	mitogen-activated protein kinase 1	Homo sapiens	48-51
19376607-7	2009	Apicidin also decreased phosphorylation of both Erk and Akt.	apicidin	0-8	AKT serine/threonine kinase 1	Homo sapiens	56-59
19376607-8	2009	Expression of constitutively-active Mek1 and Akt significantly decreased apicidin-induced apoptosis.	apicidin	73-81	mitogen-activated protein kinase kinase 1	Homo sapiens	36-40
19376607-8	2009	Expression of constitutively-active Mek1 and Akt significantly decreased apicidin-induced apoptosis.	apicidin	73-81	AKT serine/threonine kinase 1	Homo sapiens	45-48
19376607-9	2009	The combination of doxorubicin with apicidin significantly increased the anti-tumor effect in the SULF1-expressing Huh7 and Hep3B cells as compared to either apicidin or doxorubicin alone, both in vitro and in vivo.	apicidin	36-44	sulfatase 1	Homo sapiens	98-103
19376607-9	2009	The combination of doxorubicin with apicidin significantly increased the anti-tumor effect in the SULF1-expressing Huh7 and Hep3B cells as compared to either apicidin or doxorubicin alone, both in vitro and in vivo.	apicidin	36-44	MIR7-3 host gene	Homo sapiens	115-119
19070610-9	2009	These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells.	apicidin	122-130	poly(ADP-ribose) polymerase 1	Homo sapiens	32-58
19070610-9	2009	These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells.	apicidin	122-130	poly(ADP-ribose) polymerase 1	Homo sapiens	60-64
19070610-9	2009	These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells.	apicidin	122-130	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105
19070610-9	2009	These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells.	apicidin	122-130	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105
19070610-9	2009	These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells.	apicidin	122-130	caspase 3	Homo sapiens	172-181
19070610-9	2009	These results were confirmed by poly-ADP ribose polymerase (PARP), an 85-kDa fragment resulting from PARP cleavage, where apicidin increased the level of PARP cleavage and caspase-3 activity in 1.0 microM apicidin-treated cells.	apicidin	205-213	poly(ADP-ribose) polymerase 1	Homo sapiens	60-64
19070610-10	2009	Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio.	apicidin	0-8	caspase 3	Homo sapiens	35-44
19070610-10	2009	Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio.	apicidin	0-8	cytochrome c, somatic	Homo sapiens	104-116
19070610-10	2009	Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio.	apicidin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144
19070610-10	2009	Apicidin-induced apoptosis through caspase-3 activation was confirmed by the increase in the release of cytochrome c and the decrease in the Bax/Bcl-2 ratio.	apicidin	0-8	BCL2 apoptosis regulator	Homo sapiens	145-150
19407971-4	2009	Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized.	apicidin	154-162	peroxisome proliferator activated receptor gamma	Mus musculus	73-82
19407971-4	2009	Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized.	apicidin	154-162	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	94-104
19407971-4	2009	Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized.	apicidin	154-162	adducin 1 (alpha)	Mus musculus	106-110
19407971-4	2009	Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized.	apicidin	154-162	sterol regulatory element binding transcription factor 1	Mus musculus	111-118
19407971-4	2009	Accordingly, the expression of adipogenic marker genes such as FAS, aP2, PPARgamma, resistin, C/EBPalpha, ADD1/SREBP1c, and adiponectin were inhibited by apicidin treatment but not NaB, indicating that the adipocyte differentiation process could be differentially regulated depending on the type of HDAC inhibitor utilized.	apicidin	154-162	adiponectin, C1Q and collagen domain containing	Mus musculus	124-135
19505402-0	2009	Apicidin, the histone deacetylase inhibitor, suppresses Th1 polarization of murine bone marrow-derived dendritic cells.	apicidin	0-8	negative elongation factor complex member C/D, Th1l	Mus musculus	56-59
19505402-4	2009	We observed that apicidin significantly attenuated surface molecule expression in LPS-stimulated DCs, suppressed production of interleukin (IL)-12 and proinflammatory cytokines (IL-6 and TNF-alpha) by DCs, and reduced IFN-gama production by T cells.	apicidin	17-25	interleukin 6	Mus musculus	178-182
19505402-4	2009	We observed that apicidin significantly attenuated surface molecule expression in LPS-stimulated DCs, suppressed production of interleukin (IL)-12 and proinflammatory cytokines (IL-6 and TNF-alpha) by DCs, and reduced IFN-gama production by T cells.	apicidin	17-25	tumor necrosis factor	Mus musculus	187-196
17828306-2	2008	Here, we report that DNMT1 abnormally expressed in HeLa cells is downregulated by a histone deacetylase (HDAC) inhibitor apicidin, which is correlated with induction of repressive histone modifications on the promoter site.	apicidin	121-129	DNA methyltransferase 1	Homo sapiens	21-26
19267380-1	2009	Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration.	apicidin	47-55	histone deacetylase 9	Homo sapiens	92-111
19267380-1	2009	Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration.	apicidin	47-55	histone deacetylase 9	Homo sapiens	113-117
19267380-3	2009	One analogue proved in some cases to be superior to apicidin as an HDAC inhibitor.	apicidin	52-60	histone deacetylase 9	Homo sapiens	67-71
18275843-0	2008	Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein.	apicidin	30-38	histone deacetylase 9	Homo sapiens	0-19
18275843-0	2008	Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein.	apicidin	30-38	ATP binding cassette subfamily B member 1	Homo sapiens	80-94
18275843-2	2008	In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression.	apicidin	69-77	histone deacetylase 9	Homo sapiens	32-51
18275843-2	2008	In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression.	apicidin	69-77	histone deacetylase 9	Homo sapiens	53-57
18275843-2	2008	In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression.	apicidin	69-77	ATP binding cassette subfamily B member 1	Homo sapiens	151-155
18275843-3	2008	Furthermore, apicidin dramatically increases the release of a fluorescent P-gp substrate, rhodamine 123, from cells.	apicidin	13-21	ATP binding cassette subfamily B member 1	Homo sapiens	74-78
18275843-4	2008	In parallel, apicidin resistance to the apoptotic potential of paclitaxel is associated with induction of P-gp expression in HeLa cells, as evidenced by specific inhibition of P-gp function using either the pharmacological inhibitor verapamil or RNA silencing.	apicidin	13-21	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
18275843-4	2008	In parallel, apicidin resistance to the apoptotic potential of paclitaxel is associated with induction of P-gp expression in HeLa cells, as evidenced by specific inhibition of P-gp function using either the pharmacological inhibitor verapamil or RNA silencing.	apicidin	13-21	ATP binding cassette subfamily B member 1	Homo sapiens	176-180
18275843-5	2008	We also demonstrate the contribution of apicidin-induced functional P-gp expression to drug resistance using KB cells.	apicidin	40-48	ATP binding cassette subfamily B member 1	Homo sapiens	68-72
18275843-7	2008	Although HDAC inhibitors are widely appreciated as a new class of anti-tumor agent, our findings clearly demonstrate that apicidin treatment may lead to P-gp-mediated resistance to other anti-tumor agents, suggesting a need for careful design of clinical applications using HDAC inhibitors.	apicidin	122-130	ATP binding cassette subfamily B member 1	Homo sapiens	153-157
18275843-7	2008	Although HDAC inhibitors are widely appreciated as a new class of anti-tumor agent, our findings clearly demonstrate that apicidin treatment may lead to P-gp-mediated resistance to other anti-tumor agents, suggesting a need for careful design of clinical applications using HDAC inhibitors.	apicidin	122-130	histone deacetylase 9	Homo sapiens	274-278
18313654-0	2008	Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells.	apicidin	43-51	estrogen receptor 1	Homo sapiens	55-72
18313654-0	2008	Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells.	apicidin	43-51	estrogen receptor 1	Homo sapiens	74-76
18313654-5	2008	In MCF-7 cells, the expression of ERalpha and ERbeta was decreased in a dose-dependent manner after apicidin treatment.	apicidin	100-108	estrogen receptor 1	Homo sapiens	34-41
18313654-5	2008	In MCF-7 cells, the expression of ERalpha and ERbeta was decreased in a dose-dependent manner after apicidin treatment.	apicidin	100-108	estrogen receptor 2	Homo sapiens	46-52
18313654-7	2008	Apicidin (300 nM) significantly induced expression of p21Waf1 and p27Kip1.	apicidin	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	66-73
18313654-12	2008	Additionally, apicidin significantly increased the bax/bcl-2 ratio in MCF-7 cells.	apicidin	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54
18313654-12	2008	Additionally, apicidin significantly increased the bax/bcl-2 ratio in MCF-7 cells.	apicidin	14-22	BCL2 apoptosis regulator	Homo sapiens	55-60
18313654-13	2008	These results suggest that apicidin inhibits proliferation of ER-positive MCF-7 breast cancer cells by altering the expression of cell cycle regulator proteins and inducing apoptotic cell death.	apicidin	27-35	estrogen receptor 1	Homo sapiens	62-64
18313654-14	2008	These distinctive cell-specific effects of apicidin on the modulation of cell cycle arrest and apoptosis may be associated with ERalpha-mediated transcriptional regulation.	apicidin	43-51	estrogen receptor 1	Homo sapiens	128-135
17929017-3	2008	In this study, we selected three structurally different histone deacetylase (HDAC) inhibitors, apicidin, MS275, and sodium butyrate that activate p38, to probe the signal pathway from activin A to p38 in chronic myeloid leukemia (CML)-derived K562 cells.	apicidin	95-103	mitogen-activated protein kinase 14	Homo sapiens	146-149
18288380-7	2008	Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines.	apicidin	0-8	cyclin dependent kinase 2	Homo sapiens	51-55
18288380-7	2008	Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines.	apicidin	0-8	cyclin D1	Homo sapiens	83-92
18288380-7	2008	Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	186-190
18288380-7	2008	Apicidin attenuated the expression of cyclin E and CDK2 in MCF10A cells, decreased cyclin D1 and cyclin E levels in MCF10A-ras cells, and increased the levels of CDK inhibitors, p21WAF1/Cip1 and p27Kip1, in both cell lines.	apicidin	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	195-202
18288380-9	2008	Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of p53 and the downstream activation of ERK in MCF10A-ras cells.	apicidin	51-59	tumor protein p53	Homo sapiens	89-92
18288380-9	2008	Studies on the regulation of apoptosis showed that apicidin induces the up-regulation of p53 and the downstream activation of ERK in MCF10A-ras cells.	apicidin	51-59	mitogen-activated protein kinase 1	Homo sapiens	126-129
18288380-11	2008	In addition, apicidin significantly increased the levels of ERK1/2 phosphorylation in MCF10A-ras cells.	apicidin	13-21	mitogen-activated protein kinase 3	Homo sapiens	60-66
18288380-12	2008	Therefore, the apicidin-mediated ERK pathway appears to play an important role in modulating the pro-apoptotic pathway in MCF10A-ras cells.	apicidin	15-23	mitogen-activated protein kinase 1	Homo sapiens	33-36
17828306-3	2008	Apicidin selectively represses the expression of DNMT1 among DNMTs in HeLa cells, independent of cell cycle arrest at G0/G1.	apicidin	0-8	DNA methyltransferase 1	Homo sapiens	49-54
17828306-7	2008	The downregulation of DNMT1 expression seems to require de novo protein synthesis, because the apicidin effect is antagonized by cycloheximide treatment.	apicidin	95-103	DNA methyltransferase 1	Homo sapiens	22-27
17935135-12	2008	Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia.	apicidin	7-15	von Hippel-Lindau tumor suppressor	Homo sapiens	103-107
17868033-6	2008	MS-275 was HDAC1-selective, MGCD0103 was HDAC1- and HDAC2-selective, apicidin was HDAC2- and HDAC3-selective and valproic acid was a specific inhibitor of class I HDACs.	apicidin	69-77	histone deacetylase 2	Homo sapiens	82-87
18504399-3	2008	The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA.	apicidin	20-28	factor interacting with PAPOLA and CPSF1	Homo sapiens	168-174
17935135-12	2008	Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia.	apicidin	7-15	histone deacetylase 9	Homo sapiens	20-24
17935135-12	2008	Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia.	apicidin	7-15	histone deacetylase 9	Homo sapiens	72-76
18504399-3	2008	The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA.	apicidin	20-28	factor interacting with PAPOLA and CPSF1	Homo sapiens	223-229
18504399-3	2008	The HDAC inhibitors apicidin and n-butyrate suppress the proliferation of EoL-1 cells and induce differentiation into eosinophils by a decrease in the protein level of FIP1L1-PDGFRalpha without affecting the mRNA level for FIP1L1-PDGFRA.	apicidin	20-28	platelet derived growth factor receptor alpha	Homo sapiens	230-236
18504399-4	2008	In this study, we analyzed the mechanism by which the protein level of FIP1L1-PDGFRalpha is decreased by apicidin and n-butyrate.	apicidin	105-113	factor interacting with PAPOLA and CPSF1	Homo sapiens	71-77
18504399-8	2008	RESULTS: When apicidin- and n-butyrate-treated EoL-1 cells were incubated in the presence of actinomycin D, the decrease in the protein level of FIP1L1-PDGFRalpha was significantly enhanced when compared with controls.	apicidin	14-22	factor interacting with PAPOLA and CPSF1	Homo sapiens	145-151
18504399-10	2008	Apicidin and n-butyrate induced the continuous phosphorylation of eIF-2alpha for up to 8 days.	apicidin	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	66-76
17257588-0	2007	PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.	apicidin	81-89	protein kinase C epsilon	Homo sapiens	0-10
17910885-0	2007	Mechanisms of human gamma-globin transcriptional induction by apicidin involves p38 signaling to chromatin.	apicidin	62-70	hemoglobin subunit gamma 1	Homo sapiens	20-32
17910885-0	2007	Mechanisms of human gamma-globin transcriptional induction by apicidin involves p38 signaling to chromatin.	apicidin	62-70	mitogen-activated protein kinase 14	Homo sapiens	80-83
17910885-2	2007	The HDAC inhibitor apicidin was recently reported as a powerful inducer of HbF via a mechanism involving p38 signaling.	apicidin	19-27	mitogen-activated protein kinase 14	Homo sapiens	105-108
17910885-4	2007	First, we compared histone 3 (H3) acetylation patterns of approximately 70kb beta-globin loci in K562 erythroid versus HeLa cells upon apicidin treatment by chromatin immunoprecipitation assays.	apicidin	135-143	H3 clustered histone 14	Homo sapiens	19-32
17910885-4	2007	First, we compared histone 3 (H3) acetylation patterns of approximately 70kb beta-globin loci in K562 erythroid versus HeLa cells upon apicidin treatment by chromatin immunoprecipitation assays.	apicidin	135-143	hemoglobin subunit beta	Homo sapiens	77-88
17910885-6	2007	Inhibition of p38 signaling blocks the effects of apicidin-induced gamma-globin expression and H3 acetylation.	apicidin	50-58	mitogen-activated protein kinase 14	Homo sapiens	14-17
17910885-6	2007	Inhibition of p38 signaling blocks the effects of apicidin-induced gamma-globin expression and H3 acetylation.	apicidin	50-58	hemoglobin subunit gamma 1	Homo sapiens	67-79
17910885-7	2007	In parallel, we assessed the recruitment of transcriptional complex to beta-globin locus following apicidin treatment.	apicidin	99-107	hemoglobin subunit beta	Homo sapiens	71-82
17910885-10	2007	Collectively, our results provide a molecular basis to elucidate the underlying mechanisms involving p38 signaling pathway in the inducement of gamma-globin transcriptional expression by apicidin.	apicidin	187-195	mitogen-activated protein kinase 14	Homo sapiens	101-104
17910885-10	2007	Collectively, our results provide a molecular basis to elucidate the underlying mechanisms involving p38 signaling pathway in the inducement of gamma-globin transcriptional expression by apicidin.	apicidin	187-195	hemoglobin subunit gamma 1	Homo sapiens	144-156
17675290-3	2007	We find that TSA and four other HDACi (apicidin, MS-275, sodium butyrate, and valproic acid) all inhibit by approximately 90% TF activity and protein level induction in human umbilical vein endothelial cells stimulated by the physiologic agonists tumor necrosis factor (TNF)-alpha, interleukin-1beta, lipopolysaccharide, and HOSCN without affecting expression of the NF-kappaB-regulated adhesion molecules ICAM-1 and E-selectin.	apicidin	39-47	coagulation factor III, tissue factor	Homo sapiens	126-128
17407153-4	2007	In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells.	apicidin	33-41	histone deacetylase 9	Homo sapiens	18-22
17407153-4	2007	In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells.	apicidin	33-41	cyclin D3	Homo sapiens	182-191
17407153-4	2007	In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells.	apicidin	33-41	histone deacetylase 9	Homo sapiens	207-211
17407153-5	2007	We found that apicidin increases the transcriptional activity of cyclin D3 gene, which results in accumulation of cyclin D3 mRNA and protein.	apicidin	14-22	cyclin D3	Homo sapiens	65-74
17407153-5	2007	We found that apicidin increases the transcriptional activity of cyclin D3 gene, which results in accumulation of cyclin D3 mRNA and protein.	apicidin	14-22	cyclin D3	Homo sapiens	114-123
17407153-6	2007	Apicidin-induced cyclin D3 expression is mediated by Sp1 sites within the cyclin D3 promoter.	apicidin	0-8	cyclin D3	Homo sapiens	17-26
17407153-6	2007	Apicidin-induced cyclin D3 expression is mediated by Sp1 sites within the cyclin D3 promoter.	apicidin	0-8	cyclin D3	Homo sapiens	74-83
17407153-7	2007	Apicidin-mediated cyclin D3 expression is attenuated by rottlerin, a specific protein kinase C-delta (PKC-delta) inhibitor, but not mitogen-activated protein kinases (MAPKs) inhibitors.	apicidin	0-8	cyclin D3	Homo sapiens	18-27
17407153-8	2007	Furthermore, suppression of PKC-delta expression by transfection with its siRNA prominently attenuated apicidin-induced cyclin D3 expression.	apicidin	103-111	cyclin D3	Homo sapiens	120-129
17407153-9	2007	These results indicate that the cyclin D3 induction caused by apicidin was associated with PKC-delta signaling pathway not MAPKs signaling pathways.	apicidin	62-70	cyclin D3	Homo sapiens	32-41
17407153-10	2007	Taken together, these results suggest that the activation of cyclin D3 transcription by HDAC inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of PKC-delta.	apicidin	103-111	cyclin D3	Homo sapiens	61-70
17407153-10	2007	Taken together, these results suggest that the activation of cyclin D3 transcription by HDAC inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of PKC-delta.	apicidin	103-111	histone deacetylase 9	Homo sapiens	88-92
17257588-0	2007	PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.	apicidin	81-89	gelsolin	Homo sapiens	28-36
17257588-2	2007	In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells.	apicidin	148-156	protein kinase C epsilon	Homo sapiens	46-49
17257588-2	2007	In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells.	apicidin	148-156	gelsolin	Homo sapiens	102-110
17257588-3	2007	Apicidin induces gelsolin mRNA independently of the de novo protein synthesis.	apicidin	0-8	gelsolin	Homo sapiens	17-25
17257588-5	2007	Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process.	apicidin	133-141	protein kinase C epsilon	Homo sapiens	27-37
17257588-5	2007	Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process.	apicidin	133-141	gelsolin	Homo sapiens	121-129
17257588-6	2007	In parallel, apicidin induction of gelsolin is antagonized by the inhibition of Sp1 using dominant-negative Sp1 or specific Sp1 inhibitor mithramycin, and inhibition of PKC leads to suppression of Sp1 promoter activity.	apicidin	13-21	gelsolin	Homo sapiens	35-43
17257588-7	2007	Our results provide mechanistic insights into molecular mechanisms of gelsolin induction by apicidin.	apicidin	92-100	gelsolin	Homo sapiens	70-78
17541273-7	2007	RESULTS: Treatment of EoL-1 cells with apicidin at 100 nM or n-butyrate at 500 microM decreased the levels of FIP1L1-PDGFRalpha protein and phosphorylated-Stat5, while that with trichostatin A at 30 nM did not.	apicidin	39-47	factor interacting with PAPOLA and CPSF1	Homo sapiens	110-116
17258775-4	2007	It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils.	apicidin	25-33	platelet derived growth factor receptor alpha	Homo sapiens	188-194
17258775-4	2007	It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils.	apicidin	25-33	integrin subunit beta 7	Homo sapiens	270-284
17258775-4	2007	It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils.	apicidin	25-33	C-C motif chemokine receptor 1	Homo sapiens	286-290
17258775-4	2007	It was demonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited the proliferation of EoL-1 cells without attenuating the level of FIP1L1-PDGFRA mRNA, and induced the expression of markers for mature eosinophils such as integrin beta7, CCR1, and CCR3 on EoL-1 cells, while trichostatin A evoked a transient acetylation of histones and induced no differentiation into eosinophils.	apicidin	25-33	C-C motif chemokine receptor 3	Homo sapiens	296-300
17273746-3	2007	Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1alpha protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines.	apicidin	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
17273746-3	2007	Here, we observed that several HDACIs (TSA, SB, Apicidin, and VPA) dramatically decreased HIF-1alpha protein level and transcriptional activity of HIF-1 in human and mouse tumor cell lines.	apicidin	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-95
17541273-8	2007	CONCLUSIONS: The decrease in the level of FIP1L1-PDGFRalpha protein caused by apicidin and n-butyrate might be one of the mechanisms by which EoL-1 cells are induced to differentiate into eosinophils by these HDAC inhibitors.	apicidin	78-86	factor interacting with PAPOLA and CPSF1	Homo sapiens	42-48
16628233-2	2006	Here, we demonstrate a new mechanism for activation of nuclear factor-kappaB (NF-kappaB) by HDAC inhibitor apicidin and the role of NF-kappaB signaling pathway for mediating differential cellular responses, especially, apoptosis.	apicidin	107-115	histone deacetylase 9	Homo sapiens	92-96
16628233-3	2006	Treatment of HeLa cells with apicidin increases transcriptional activity of NF-kappaB and its target gene IL-8 and cIAP-1 induction, which involves the activation of IKK-IkappaBalpha signaling pathway through Sp1-dependent de novo protein synthesis.	apicidin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
16628233-3	2006	Treatment of HeLa cells with apicidin increases transcriptional activity of NF-kappaB and its target gene IL-8 and cIAP-1 induction, which involves the activation of IKK-IkappaBalpha signaling pathway through Sp1-dependent de novo protein synthesis.	apicidin	29-37	baculoviral IAP repeat containing 2	Homo sapiens	115-121
16628233-4	2006	In parallel, apicidin treatment leads to histone hyperacetylation in the IL-8 promoter region independent of NF-kappaB signaling pathway, which is not sufficient for full transcription of IL-8 gene.	apicidin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
16762634-13	2006	The interaction between SULF1 and apicidin was confirmed in vivo in Huh7 and Hep3B xenografts.	apicidin	34-42	sulfatase 1	Homo sapiens	24-29
16844092-2	2006	To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells.	apicidin	111-119	histone deacetylase 9	Homo sapiens	28-32
16844092-2	2006	To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells.	apicidin	111-119	histone deacetylase 9	Homo sapiens	59-63
16844092-2	2006	To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells.	apicidin	111-119	carbonyl reductase 1	Homo sapiens	161-198
16844092-2	2006	To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells.	apicidin	111-119	carbonyl reductase 1	Homo sapiens	200-207
16844092-2	2006	To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells.	apicidin	111-119	prostaglandin-endoperoxide synthase 2	Homo sapiens	222-238
16844092-2	2006	To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells.	apicidin	111-119	prostaglandin-endoperoxide synthase 2	Homo sapiens	240-245
16870149-0	2006	Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.	apicidin	103-111	histone deacetylase 1	Homo sapiens	15-20
16870149-0	2006	Involvement of HDAC1 and the PI3K/PKC signaling pathways in NF-kappaB activation by the HDAC inhibitor apicidin.	apicidin	103-111	nuclear factor kappa B subunit 1	Homo sapiens	60-69
16870149-3	2006	In this study, we investigate a possible signaling pathway required for NF-kappaB activation in response to the HDAC inhibitor apicidin.	apicidin	127-135	nuclear factor kappa B subunit 1	Homo sapiens	72-81
16870149-4	2006	Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha.	apicidin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	90-99
16870149-4	2006	Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha.	apicidin	29-37	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
16870149-4	2006	Treatment of HeLa cells with apicidin leads to an increase in transcriptional activity of NF-kappaB and the expression of its target genes, IL-8 and TNF-alpha.	apicidin	29-37	tumor necrosis factor	Homo sapiens	149-158
16870149-5	2006	TNF-alpha expression by apicidin is induced at earlier time points than NF-kappaB activation or IL-8 expression.	apicidin	24-32	tumor necrosis factor	Homo sapiens	0-9
16870149-8	2006	Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity.	apicidin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	36-45
16870149-8	2006	Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity.	apicidin	13-21	histone deacetylase 1	Homo sapiens	67-72
16870149-8	2006	Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity.	apicidin	13-21	histone deacetylase 1	Homo sapiens	140-145
16870149-8	2006	Furthermore, apicidin activation of NF-kappaB seems to result from HDAC1 inhibition, as evidenced by the observation that overexpression of HDAC1, but not HDAC2, 3 or 4, dramatically inhibits NF-kappaB reporter gene activity.	apicidin	13-21	nuclear factor kappa B subunit 1	Homo sapiens	192-201
16870149-9	2006	Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin.	apicidin	76-84	nuclear factor kappa B subunit 1	Homo sapiens	53-62
16870149-9	2006	Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin.	apicidin	76-84	histone deacetylase 1	Homo sapiens	135-140
16870149-9	2006	Collectively, our results suggest that activation of NF-kappaB signaling by apicidin requires both the PI3K/PKC signaling pathways and HDAC1, and functions as a critical modulator in determining the cellular effect of apicidin.	apicidin	218-226	nuclear factor kappa B subunit 1	Homo sapiens	53-62
16762634-10	2006	(3) SULF1 enhanced the induction of apoptosis by the HDAC inhibitors apicidin and scriptaid.	apicidin	69-77	sulfatase 1	Mus musculus	4-9
16762634-10	2006	(3) SULF1 enhanced the induction of apoptosis by the HDAC inhibitors apicidin and scriptaid.	apicidin	69-77	histone deacetylase 9	Homo sapiens	53-57
16762634-12	2006	We also demonstrate that knockdown of SULF1 with shRNA constructs up-regulates phosphorylation of AKT and Erk and attenuates apicidin-induced apoptosis.	apicidin	125-133	sulfatase 1	Homo sapiens	38-43
16762634-13	2006	The interaction between SULF1 and apicidin was confirmed in vivo in Huh7 and Hep3B xenografts.	apicidin	34-42	MIR7-3 host gene	Homo sapiens	68-72
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	37-45	ATP binding cassette subfamily C member 1	Homo sapiens	158-199
16516150-0	2006	Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.	apicidin	30-38	histone deacetylase 9	Homo sapiens	0-19
16516150-1	2006	We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner.	apicidin	52-60	histone deacetylase 9	Homo sapiens	15-34
16516150-1	2006	We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner.	apicidin	52-60	histone deacetylase 9	Homo sapiens	36-40
16516150-4	2006	Our results demonstrate that regulation of histone modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent.	apicidin	85-93	histone deacetylase 9	Homo sapiens	70-74
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	37-45	ATP binding cassette subfamily B member 1	Homo sapiens	132-146
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	37-45	ATP binding cassette subfamily B member 1	Homo sapiens	148-152
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	37-45	ATP binding cassette subfamily C member 1	Homo sapiens	201-205
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	37-45	ATP binding cassette subfamily B member 1	Homo sapiens	216-220
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	37-45	ATP binding cassette subfamily C member 1	Homo sapiens	225-229
16049968-5	2006	Here, we demonstrated that FK228 and apicidin exhibited strong resistance in doxorubicin-resistant clones of OS and EFTs expressing P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) and that P-gp and MRP1 might play a crucial role in the resistance mechanism to FK228 and apicidin.	apicidin	297-305	ATP binding cassette subfamily C member 1	Homo sapiens	201-205
16049968-6	2006	A P-gp inhibitor (verapamil) and an MRP1 inhibitor (MK571) could independently reverse the resistance to FK228 and apicidin in the drug-resistant clones.	apicidin	115-123	ATP binding cassette subfamily B member 1	Homo sapiens	2-6
16049968-6	2006	A P-gp inhibitor (verapamil) and an MRP1 inhibitor (MK571) could independently reverse the resistance to FK228 and apicidin in the drug-resistant clones.	apicidin	115-123	ATP binding cassette subfamily C member 1	Homo sapiens	36-40
15210580-5	2004	Other markers for differentiation into eosinophils such as changes in intracellular structure, and expressions of integrin beta7 and major basic protein, and the inhibition of cell proliferation were also induced by apicidin and n-butyrate but not by TSA.	apicidin	216-224	integrin subunit beta 7	Homo sapiens	114-128
15710351-4	2005	Histone deacetylase inhibitors trichostatin A (TSA) and apicidin reduced the inhibitory effect of dexamethasone and RU24858 on TTP expression, but the glucocorticoids did not alter TTP mRNA half-life.	apicidin	56-64	ZFP36 ring finger protein	Homo sapiens	127-130
15710351-4	2005	Histone deacetylase inhibitors trichostatin A (TSA) and apicidin reduced the inhibitory effect of dexamethasone and RU24858 on TTP expression, but the glucocorticoids did not alter TTP mRNA half-life.	apicidin	56-64	ZFP36 ring finger protein	Homo sapiens	181-184
14581377-0	2003	Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells.	apicidin	26-34	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	140-147
14687026-0	2004	Apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells by enhancing the activation of mitochondria-dependent caspase cascades.	apicidin	0-8	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	55-62
14687026-2	2004	We examined whether apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive human leukaemia cells.	apicidin	20-28	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	75-82
14687026-5	2004	Imatinib/apicidin co-treatment for 48 h resulted in a near complete loss of the full-length XIAP (X-linked inhibitor of apoptosis) protein, with a corresponding increase in the 29-kDa XIAP cleavage product.	apicidin	9-17	X-linked inhibitor of apoptosis	Homo sapiens	92-96
14687026-5	2004	Imatinib/apicidin co-treatment for 48 h resulted in a near complete loss of the full-length XIAP (X-linked inhibitor of apoptosis) protein, with a corresponding increase in the 29-kDa XIAP cleavage product.	apicidin	9-17	X-linked inhibitor of apoptosis	Homo sapiens	98-129
14687026-5	2004	Imatinib/apicidin co-treatment for 48 h resulted in a near complete loss of the full-length XIAP (X-linked inhibitor of apoptosis) protein, with a corresponding increase in the 29-kDa XIAP cleavage product.	apicidin	9-17	X-linked inhibitor of apoptosis	Homo sapiens	184-188
14687026-7	2004	Imatinib/apicidin co-treatment for 48 h produced a prominent decrease in Bcr-Abl protein levels in a caspase-dependent manner.	apicidin	9-17	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	73-80
14687026-8	2004	In summary, these data indicate that apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive leukaemia cells through the enhanced activation of the mitochondria-dependent caspase cascades, accompanied by caspase-dependent downregulation of Bcr-Abl and XIAP.	apicidin	37-45	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	92-99
14687026-8	2004	In summary, these data indicate that apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive leukaemia cells through the enhanced activation of the mitochondria-dependent caspase cascades, accompanied by caspase-dependent downregulation of Bcr-Abl and XIAP.	apicidin	37-45	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	256-263
14687026-8	2004	In summary, these data indicate that apicidin potentiates the imatinib-induced apoptosis of Bcr-Abl-positive leukaemia cells through the enhanced activation of the mitochondria-dependent caspase cascades, accompanied by caspase-dependent downregulation of Bcr-Abl and XIAP.	apicidin	37-45	X-linked inhibitor of apoptosis	Homo sapiens	268-272
14687026-9	2004	These findings generate a rationale for further investigation of apicidin and imatinib as a potential therapeutic strategy in Bcr-Abl-positive leukaemias.	apicidin	65-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	126-133
14581377-2	2003	The aim of this study was to examine the potential of apicidin to induce apoptosis in human Bcr-Abl-positive leukemia cells and to assess the mechanism of apicidin-induced apoptosis.	apicidin	54-62	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	92-99
14581377-8	2003	The disruption of the mitochondrial membrane potential, cytochrome c release into the cytosol, and the mitochondrial Bax translocation were notably demonstrated after the apicidin treatment.	apicidin	171-179	cytochrome c, somatic	Homo sapiens	56-68
14581377-8	2003	The disruption of the mitochondrial membrane potential, cytochrome c release into the cytosol, and the mitochondrial Bax translocation were notably demonstrated after the apicidin treatment.	apicidin	171-179	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
14581377-9	2003	Apicidin induced the proteolytic cleavage of procaspase-9, -3, -8, and poly(ADP-ribose) polymerase.	apicidin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	45-98
14581377-10	2003	Pretreatment of the K562 cells with the caspase-3 inhibitor, DEVD-CHO, completely inhibited the apicidin-induced apoptosis, suggesting that apicidin-induced apoptosis was caspase-dependent.	apicidin	96-104	caspase 3	Homo sapiens	40-49
14581377-10	2003	Pretreatment of the K562 cells with the caspase-3 inhibitor, DEVD-CHO, completely inhibited the apicidin-induced apoptosis, suggesting that apicidin-induced apoptosis was caspase-dependent.	apicidin	140-148	caspase 3	Homo sapiens	40-49
14581377-12	2003	Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase.	apicidin	78-86	caspase 9	Homo sapiens	35-44
14581377-12	2003	Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase.	apicidin	78-86	caspase 3	Homo sapiens	108-124
14581377-12	2003	Pretreatment of the cells with the caspase-9 inhibitor LEHD-fmk abrogated the apicidin- induced cleavage of procaspase-3, -8, and poly(ADP-ribose) polymerase.	apicidin	78-86	poly(ADP-ribose) polymerase 1	Homo sapiens	130-157
14581377-13	2003	The p210 Bcr-Abl protein levels were notably decreased after the apicidin treatment, with near complete loss after 48 h. Reverse transcription-PCR assay demonstrated that the Bcr-Abl mRNA level was also remarkably decreased in a time-dependent manner.	apicidin	65-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	9-16
14581377-13	2003	The p210 Bcr-Abl protein levels were notably decreased after the apicidin treatment, with near complete loss after 48 h. Reverse transcription-PCR assay demonstrated that the Bcr-Abl mRNA level was also remarkably decreased in a time-dependent manner.	apicidin	65-73	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	175-182
14581377-14	2003	CONCLUSIONS: These results indicate that apicidin effectively induces the apoptosis of Bcr-Abl-positive leukemia cells through the activation of the mitochondrial pathway-dependent caspase cascades.	apicidin	41-49	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-94
14581377-15	2003	The down-regulation of Bcr-Abl mRNA might also be one of the mechanisms implicated in the apicidin-mediated apoptosis in the K562 cells.	apicidin	90-98	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	23-30
14581377-16	2003	This study provides the rationale to additionally investigate apicidin as a potential therapeutic agent for the drug-resistant Bcr-Abl-positive leukemia cells.	apicidin	62-70	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	127-134
12955081-4	2003	In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin.	apicidin	112-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-88
12955081-4	2003	In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin.	apicidin	112-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-93
12955081-0	2003	Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.	apicidin	80-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	14-17
12955081-4	2003	In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin.	apicidin	112-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-98
12955081-0	2003	Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.	apicidin	80-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-22
12955081-0	2003	Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.	apicidin	80-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-27
12955081-0	2003	Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.	apicidin	80-88	protein kinase C epsilon	Homo sapiens	110-121
12955081-1	2003	We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC).	apicidin	108-116	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-49
12955081-1	2003	We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC).	apicidin	108-116	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-54
12955081-1	2003	We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC).	apicidin	108-116	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-59
12955081-1	2003	We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC).	apicidin	108-116	protein kinase C epsilon	Homo sapiens	211-214
12955081-4	2003	In addition to PKC epsilon, PI 3-kinase appeared to participate in the activation of p21(WAF1/Cip1) promoter by apicidin, since inactivation of PI 3-kinase either by transient expression of dominant-negative mutant of PI 3-kinase or its specific inhibitors, LY294002 and wortmannin, attenuated the activation of p21(WAF1/Cip1) promoter and p21(WAF1/Cip1) protein expression by apicidin.	apicidin	112-120	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-98
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	protein kinase C epsilon	Homo sapiens	39-50
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	protein kinase C epsilon	Homo sapiens	179-190
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	198-201
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	202-206
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	cyclin dependent kinase inhibitor 1A	Homo sapiens	207-211
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	236-244	protein kinase C epsilon	Homo sapiens	39-50
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	236-244	cyclin dependent kinase inhibitor 1A	Homo sapiens	198-201
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	236-244	cyclin dependent kinase inhibitor 1A	Homo sapiens	202-206
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	42-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	13-16
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	42-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-21
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	42-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	22-26
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-165
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	166-170
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	171-175
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	protein kinase C epsilon	Homo sapiens	243-246
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-165
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	166-170
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	cyclin dependent kinase inhibitor 1A	Homo sapiens	171-175
12955081-7	2003	Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin.	apicidin	153-161	protein kinase C epsilon	Homo sapiens	59-70
12955081-7	2003	Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin.	apicidin	153-161	cyclin dependent kinase inhibitor 1A	Homo sapiens	135-138
12955081-7	2003	Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin.	apicidin	153-161	cyclin dependent kinase inhibitor 1A	Homo sapiens	139-143
12955081-7	2003	Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin.	apicidin	153-161	cyclin dependent kinase inhibitor 1A	Homo sapiens	144-148
14523559-11	2003	Chemically different types of HDAC inhibitors, such as TSA, apicidin, SAHA, M344 and n-butyrate induced remarkably similar responses in SIRT1-7 mRNA expression patterns.	apicidin	60-68	sirtuin 1	Mus musculus	136-141
12490313-4	2003	Apicidin (10-100 nM) increased the cells having nitroblue tetrazolium-reducing activity and expressing CD11b but not CD14 and CD15.	apicidin	0-8	integrin subunit alpha M	Homo sapiens	103-108
12393499-5	2003	Furthermore, analysis of different mitogen-activated protein (MAP) kinase signaling pathways revealed that p38 signaling was activated following apicidin treatment of cells and that inhibition of this pathway abolished the HbF-inducing effect of apicidin.	apicidin	145-153	mitogen-activated protein kinase 14	Homo sapiens	107-110
12393499-5	2003	Furthermore, analysis of different mitogen-activated protein (MAP) kinase signaling pathways revealed that p38 signaling was activated following apicidin treatment of cells and that inhibition of this pathway abolished the HbF-inducing effect of apicidin.	apicidin	246-254	mitogen-activated protein kinase 14	Homo sapiens	107-110
12393499-6	2003	Additionally, activation of the Agamma-globin promoter by apicidin could be inhibited by p38 inhibitor SB203580.	apicidin	58-66	mitogen-activated protein kinase 14	Homo sapiens	89-92
12490313-5	2003	The expression of CD11b by apicidin was long lasting, while that by trichostatin A was transient.	apicidin	27-35	integrin subunit alpha M	Homo sapiens	18-23
11698395-0	2002	Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells.	apicidin	0-8	Fas ligand	Homo sapiens	69-79
12678732-4	2002	In the class of HDAC inhibitors, now included a short-chain fatty acids, such as 4-phenylbutyrate and valporic acid, hydroxamic acids, such as suberoylanilide hydroxamic acid (SAHA), pyroxamide, trichostatin A, oxamflatin and CHAPSs, cyclic tetrapeptides, such as trapoxin, apicidin and depsipeptide-also known as FK-228 or FR 901228, and benzamides, such as MS-275.	apicidin	274-282	histone deacetylase 9	Homo sapiens	16-20
11698395-1	2002	We previously reported that apicidin arrested human cancer cell growth through selective induction of p21(WAF1/Cip1).	apicidin	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	102-105
11698395-7	2002	The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis.	apicidin	168-176	caspase 3	Homo sapiens	62-71
11698395-1	2002	We previously reported that apicidin arrested human cancer cell growth through selective induction of p21(WAF1/Cip1).	apicidin	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	106-110
11698395-7	2002	The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis.	apicidin	168-176	caspase 3	Homo sapiens	116-128
11698395-1	2002	We previously reported that apicidin arrested human cancer cell growth through selective induction of p21(WAF1/Cip1).	apicidin	28-36	cyclin dependent kinase inhibitor 1A	Homo sapiens	111-115
11698395-8	2002	Consistent with these results, apicidin transiently increased the expressions of both Fas and Fas ligand.	apicidin	31-39	Fas ligand	Homo sapiens	94-104
11698395-4	2002	In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	13-21	caspase 3	Homo sapiens	36-48
11698395-9	2002	Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation.	apicidin	144-152	Fas ligand	Homo sapiens	69-79
11698395-4	2002	In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	134-161
11698395-9	2002	Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation.	apicidin	144-152	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
11698395-9	2002	Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation.	apicidin	144-152	cytochrome c, somatic	Homo sapiens	183-195
11698395-9	2002	Preincubation with NOK-1 monoclonal antibody, which prevents the Fas-Fas ligand interaction and is inhibitory to Fas signaling, interfered with apicidin-induced translocation of Bax, cytochrome c release, cleavage of procaspase-3, and DNA fragmentation.	apicidin	144-152	caspase 3	Homo sapiens	217-229
11698395-10	2002	Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3.	apicidin	41-49	Fas ligand	Homo sapiens	108-118
11698395-10	2002	Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3.	apicidin	41-49	cytochrome c, somatic	Homo sapiens	148-160
11698395-10	2002	Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3.	apicidin	41-49	caspase 9	Homo sapiens	227-236
11698395-10	2002	Taken together, the results suggest that apicidin might induce apoptosis through selective induction of Fas/Fas ligand, resulting in the release of cytochrome c from the mitochondria to the cytosol and subsequent activation of caspase-9 and caspase-3.	apicidin	41-49	caspase 3	Homo sapiens	241-250
11698395-4	2002	In addition, apicidin converted the procaspase-3 form to catalytically active effector protease, resulting in subsequent cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	166-179
11698395-5	2002	Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	93-101	caspase 3	Homo sapiens	44-53
11698395-5	2002	Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	93-101	caspase 3	Homo sapiens	124-133
11698395-5	2002	Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	93-101	poly(ADP-ribose) polymerase 1	Homo sapiens	171-198
11698395-5	2002	Incubation of HL60 cells with z-DEVD-fmk, a caspase-3 inhibitor, almost completely abrogated apicidin-induced activation of caspase-3, DNA fragmentation, and cleavages of poly(ADP-ribose) polymerase and p21(WAF1/Cip1).	apicidin	93-101	cyclin dependent kinase inhibitor 1A	Homo sapiens	203-216
11698395-7	2002	The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis.	apicidin	75-83	caspase 3	Homo sapiens	62-71
11698395-7	2002	The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis.	apicidin	75-83	caspase 3	Homo sapiens	116-128
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	protein kinase C epsilon	Homo sapiens	134-144
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	protein kinase C epsilon	Homo sapiens	134-137
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	310-313
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	314-318
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	319-323
11085529-0	2000	Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	106-110
11085529-0	2000	Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.	apicidin	0-8	gelsolin	Homo sapiens	115-123
11085529-5	2000	In addition, apicidin induced selective changes in the expression of p21WAF1/Cip1 and gelsolin, which control the cell cycle and cell morphology, respectively.	apicidin	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	77-81
11085529-5	2000	In addition, apicidin induced selective changes in the expression of p21WAF1/Cip1 and gelsolin, which control the cell cycle and cell morphology, respectively.	apicidin	13-21	gelsolin	Homo sapiens	86-94
11085529-7	2000	The effects of apicidin on cell morphology, expression of gelsolin, and HDAC1 activity in vivo and in vitro appeared to be irreversible, because withdrawal of apicidin did not reverse those effects, whereas the induction of p21WAF1/Cip1 by apicidin was reversible.	apicidin	15-23	gelsolin	Homo sapiens	58-66
10893438-0	2000	Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype.	apicidin	0-8	histone deacetylase 9	Homo sapiens	26-45
10893438-2	2000	In the present study, we have examined the anti-invasive effect of apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amin o-8-oxodecanoyl)], a fungal metabolite that was identified as an antiprotozoal agent known to inhibit parasite histone deacetylase (HDAC).	apicidin	67-75	histone deacetylase 9	Homo sapiens	258-277
10893438-2	2000	In the present study, we have examined the anti-invasive effect of apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amin o-8-oxodecanoyl)], a fungal metabolite that was identified as an antiprotozoal agent known to inhibit parasite histone deacetylase (HDAC).	apicidin	67-75	histone deacetylase 9	Homo sapiens	279-283
10893438-3	2000	We show that apicidin significantly inhibits H-ras-induced invasive phenotype of MCF10A human breast epithelial cells in parallel with a specific downregulation of matrix metalloproteinase (MMP)-2, but not MMP-9.	apicidin	13-21	matrix metallopeptidase 2	Homo sapiens	164-196
10893438-4	2000	We also show that apicidin induces a morphological reversal and growth inhibition of H-ras MCF10A cells similar to that induced by other HDAC inhibitors.	apicidin	18-26	histone deacetylase 9	Homo sapiens	137-141
11551946-0	2001	Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1).	apicidin	94-102	cyclin dependent kinase inhibitor 1A	Homo sapiens	14-17
11551946-0	2001	Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1).	apicidin	94-102	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-22
11551946-0	2001	Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. We previously reported that apicidin, a novel histone deacetylase inhibitor, inhibited the proliferation of tumor cells via induction of p21(WAF1/Cip1).	apicidin	94-102	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-27
11551946-1	2001	In this study, we determined the molecular mechanisms by which apicidin induced the p21(WAF1/Cip1) gene expression in HeLa cells.	apicidin	63-71	cyclin dependent kinase inhibitor 1A	Homo sapiens	84-87
11551946-1	2001	In this study, we determined the molecular mechanisms by which apicidin induced the p21(WAF1/Cip1) gene expression in HeLa cells.	apicidin	63-71	cyclin dependent kinase inhibitor 1A	Homo sapiens	88-92
11551946-1	2001	In this study, we determined the molecular mechanisms by which apicidin induced the p21(WAF1/Cip1) gene expression in HeLa cells.	apicidin	63-71	cyclin dependent kinase inhibitor 1A	Homo sapiens	93-97
11551946-2	2001	Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	17-20
11551946-2	2001	Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	21-25
11551946-2	2001	Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-30
11551946-2	2001	Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-103
11551946-2	2001	Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	104-108
11551946-2	2001	Apicidin induced p21(WAF1/Cip1) mRNA independent of the de novo protein synthesis and activated the p21(WAF1/Cip1) promoter through Sp1-3 site located at -82 and -77 relative to the transcription start site.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	109-113
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	77-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-53
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	77-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	54-58
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	77-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-63
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	77-85	protein kinase C epsilon	Homo sapiens	134-144
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	50-53
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	54-58
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	59-63
11237739-0	2001	Transcriptional activation of p21(WAF1/CIP1) by apicidin, a novel histone deacetylase inhibitor.	apicidin	48-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-43
11237739-2	2001	In this study, we show apicidin induces transcriptional activation of p21(WAF1/CIP1) (p21) in human prostate carcinoma cells.	apicidin	23-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-83
11237739-2	2001	In this study, we show apicidin induces transcriptional activation of p21(WAF1/CIP1) (p21) in human prostate carcinoma cells.	apicidin	23-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-73
11237739-3	2001	Apicidin induces expression of p21 protein and mRNA and activation of p21 promoter-luciferase reporter constructs.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	31-34
11237739-3	2001	Apicidin induces expression of p21 protein and mRNA and activation of p21 promoter-luciferase reporter constructs.	apicidin	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-73
11237739-5	2001	Chromatin immunoprecipitation shows p21 promoter DNA is associated with hyperacetylated histones H3 and H4 after treatment with apicidin.	apicidin	128-136	cyclin dependent kinase inhibitor 1A	Homo sapiens	36-39
11237739-6	2001	Therefore, the data here demonstrate that apicidin activates p21 transcription associated with the acetylation of histones H3 and H4.	apicidin	42-50	cyclin dependent kinase inhibitor 1A	Homo sapiens	61-64
11085529-7	2000	The effects of apicidin on cell morphology, expression of gelsolin, and HDAC1 activity in vivo and in vitro appeared to be irreversible, because withdrawal of apicidin did not reverse those effects, whereas the induction of p21WAF1/Cip1 by apicidin was reversible.	apicidin	15-23	histone deacetylase 1	Homo sapiens	72-77
11085529-7	2000	The effects of apicidin on cell morphology, expression of gelsolin, and HDAC1 activity in vivo and in vitro appeared to be irreversible, because withdrawal of apicidin did not reverse those effects, whereas the induction of p21WAF1/Cip1 by apicidin was reversible.	apicidin	15-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	232-236