PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29553092-5	2018	Among 50 natural compounds, aculeatiside A, naringin, and onionin A significantly induced the CD169-positive phenotype in human monocyte-derived macrophages.	naringin	44-52	sialic acid binding Ig like lectin 1	Homo sapiens	94-99
30884485-0	2018	Naringin (4",5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates beta-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1.	naringin	0-8	pancreatic and duodenal homeobox 1	Rattus norvegicus	130-135
30884485-0	2018	Naringin (4",5,7-Trihydroxyflavanone 7-Rhamnoglucoside) Attenuates beta-Cell Dysfunction in Diabetic Rats through Upregulation of PDX-1.	naringin	10-54	pancreatic and duodenal homeobox 1	Rattus norvegicus	130-135
30884485-8	2018	Naringin-treated diabetic rats showed significantly increased mRNA expression of Pdx-1 and Insulin genes, increased expression of transcription factor PDX-1, and higher serum insulin levels than the diabetic control animals.	naringin	0-8	pancreatic and duodenal homeobox 1	Rattus norvegicus	81-86
30884485-8	2018	Naringin-treated diabetic rats showed significantly increased mRNA expression of Pdx-1 and Insulin genes, increased expression of transcription factor PDX-1, and higher serum insulin levels than the diabetic control animals.	naringin	0-8	pancreatic and duodenal homeobox 1	Rattus norvegicus	151-156
30884485-10	2018	CONCLUSIONS: Naringin was found to be an effective antidiabetic agent which increased Insulin gene expression and insulin secretion by upregulating the PDX-1 gene and protein expression.	naringin	13-21	pancreatic and duodenal homeobox 1	Rattus norvegicus	152-157
31067533-9	2018	Naringin-treated diabetic rats showed a significant increase in mRNA and protein expression of FoxM1 compared to the diabetic control rats, indicating regeneration of cells.	naringin	0-8	forkhead box M1	Rattus norvegicus	95-100
29553092-7	2018	Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1beta, IL12, and CD169 in regional lymph nodes in mice.	naringin	45-53	interleukin 1 beta	Mus musculus	82-90
29553092-7	2018	Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1beta, IL12, and CD169 in regional lymph nodes in mice.	naringin	45-53	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	102-107
29553092-8	2018	These findings suggest aculeatiside A and naringin may enhance anti-tumor immune responses by inducing CD169-positive macrophages in lymph nodes.	naringin	42-50	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	103-108
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	187-199
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	sucrase-isomaltase	Homo sapiens	202-219
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	255-259
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	acetylcholinesterase (Cartwright blood group)	Homo sapiens	233-253
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	butyrylcholinesterase	Homo sapiens	266-287
28902458-3	2017	In this study, chrysin, carvacrol, hesperidin, zingerone, and naringin as natural phenols showed excellent inhibitory effects against human (h) carbonic anhydrase (CA) isoforms I and II (hCA I and II), alpha-glucosidase (alpha-Gly), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE).	naringin	62-70	butyrylcholinesterase	Homo sapiens	289-293
28395989-0	2017	Naringin ameliorates diabetic nephropathy by inhibiting NADPH oxidase 4.	naringin	0-8	NADPH oxidase 4	Rattus norvegicus	56-71
27937032-2	2017	Naringin (Nar) is a bioflavonoid that has antioxidant activity and suppresses MMP-9 expression.	naringin	0-8	matrix metallopeptidase 9	Rattus norvegicus	78-83
27937032-2	2017	Naringin (Nar) is a bioflavonoid that has antioxidant activity and suppresses MMP-9 expression.	naringin	0-3	matrix metallopeptidase 9	Rattus norvegicus	78-83
28832643-0	2017	Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia.	naringin	10-18	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
28832643-0	2017	Effect of naringin on gp120-induced injury mediated by P2X7 receptors in rat primary cultured microglia.	naringin	10-18	purinergic receptor P2X 7	Homo sapiens	55-59
28789364-0	2017	Effects of naringin on the expression of miR-19b and cell apoptosis in human hepatocellular carcinoma.	naringin	11-19	microRNA 19b-1	Homo sapiens	41-48
28789364-1	2017	The effects of naringin on the expression of miR-19b and cell apoptosis were investigated in the human hepatocellular carcinoma cell line HepG2.	naringin	15-23	microRNA 19b-1	Homo sapiens	45-52
28789364-9	2017	In conclusion, naringin can upregulate the expression of miR-19b mRNA and induce HepG2 cell apoptosis.	naringin	15-23	microRNA 19b-1	Homo sapiens	57-64
28554841-8	2017	In addition, the extracellular regulated protein kinases (ERK) 1/2 was found to be activated by naringin, and the ERK1/2 specific inhibitor significantly inhibited naringin-induced osteogenic differentiation in PDLSC-Bmi1.	naringin	96-104	mitogen-activated protein kinase 3	Homo sapiens	17-66
29023372-10	2017	Glycosyl flavonoids, isoquercetin and rutin as well as naringin showed selective cytotoxicity to BRCA2-deficient cells; hesperidin did not.	naringin	55-63	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	97-102
29212216-3	2017	Naringin accelerates angiogenesis by activating the expression of vascular endothelial growth factor (VEGF).	naringin	0-8	vascular endothelial growth factor A	Rattus norvegicus	66-100
29212216-3	2017	Naringin accelerates angiogenesis by activating the expression of vascular endothelial growth factor (VEGF).	naringin	0-8	vascular endothelial growth factor A	Rattus norvegicus	102-106
28759757-8	2017	In conclusion, the navel orange peel hydroethanolic extract, naringin and naringenin have potent anti-diabetic effects in NA/STZ-induced type 2 diabetic rats via their insulinotropic effects and insulin improving action which in turn may be mediated through enhancing insulin receptor, GLUT4 and adiponectin expression in adipose tissue.	naringin	61-69	insulin receptor	Rattus norvegicus	268-284
28759757-8	2017	In conclusion, the navel orange peel hydroethanolic extract, naringin and naringenin have potent anti-diabetic effects in NA/STZ-induced type 2 diabetic rats via their insulinotropic effects and insulin improving action which in turn may be mediated through enhancing insulin receptor, GLUT4 and adiponectin expression in adipose tissue.	naringin	61-69	solute carrier family 2 member 4	Rattus norvegicus	286-291
28759757-8	2017	In conclusion, the navel orange peel hydroethanolic extract, naringin and naringenin have potent anti-diabetic effects in NA/STZ-induced type 2 diabetic rats via their insulinotropic effects and insulin improving action which in turn may be mediated through enhancing insulin receptor, GLUT4 and adiponectin expression in adipose tissue.	naringin	61-69	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	296-307
28846920-6	2017	Increased CA1 neuronal density in the hippocampus and increased cell density in the frontal and temporal regions indicate the potential of naringin to act against PTZ-induced kindling, memory impairment, oxidative stress, neurochemical changes, and histological aberrations.	naringin	139-147	carbonic anhydrase 1	Homo sapiens	10-13
28852447-10	2017	In addition, the enhanced nuclear translocation of NF-kappaB p65 in diabetic rat retina and HG-induced rMC1 cells was suppressed by naringin.	naringin	132-140	synaptotagmin 1	Rattus norvegicus	61-64
28395989-5	2017	More importantly, naringin inhibited NOX4 expression at mRNA and protein levels in STZ-induced DN rats and HG-induced podocytes.	naringin	18-26	NADPH oxidase 4	Rattus norvegicus	37-41
28395989-7	2017	Take together, this study demonstrated that naringin ameliorates diabetic nephropathy by inhibiting NOX4, contributing to a better understanding of the progression of DN.	naringin	44-52	NADPH oxidase 4	Rattus norvegicus	100-104
27833010-0	2017	Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.	naringin	0-8	vascular endothelial growth factor A	Rattus norvegicus	89-93
28804610-0	2017	Naringin enhances osteogenic differentiation through the activation of ERK signaling in human bone marrow mesenchymal stem cells.	naringin	0-8	mitogen-activated protein kinase 1	Homo sapiens	71-74
28804610-3	2017	The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation.	naringin	41-49	mitogen-activated protein kinase 1	Homo sapiens	163-166
28804610-8	2017	In addition, we found that the enhancing effect of naringin on osteogenic differentiation was related to the activation of phosphor-ERK, with an increase in duration of activity from 30 min to 120 min.	naringin	51-59	mitogen-activated protein kinase 1	Homo sapiens	132-135
27687505-10	2017	The deactivation of HSCs caused by naringin was not because of the autophagic activation but mTOR inhibition, which was supported by the following evidence: first, naringin induced autophagic activation, but when autophagy was blocked by 3-MA, deactivation of HSCs was not attenuated or reversed.	naringin	35-43	mechanistic target of rapamycin kinase	Homo sapiens	93-97
27687505-11	2017	Second, naringin inhibited mTOR pathway, meanwhile when mTOR was activated by IGF-1, deactivation of HSCs was reversed.	naringin	8-16	mechanistic target of rapamycin kinase	Homo sapiens	27-31
27687505-11	2017	Second, naringin inhibited mTOR pathway, meanwhile when mTOR was activated by IGF-1, deactivation of HSCs was reversed.	naringin	8-16	mechanistic target of rapamycin kinase	Homo sapiens	56-60
27833010-0	2017	Naringin promotes fracture healing through stimulation of angiogenesis by regulating the VEGF/VEGFR-2 signaling pathway in osteoporotic rats.	naringin	0-8	kinase insert domain receptor	Rattus norvegicus	94-101
27771282-5	2017	Western blotting and qPCR identified two inducers of BCRP (quercetin and naringin) and two down-regulators (17-beta-estradiol and curcumin) with associated changes in BCRP efflux transport function further confirmed in both cell lines.	naringin	73-81	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	53-57
27771282-5	2017	Western blotting and qPCR identified two inducers of BCRP (quercetin and naringin) and two down-regulators (17-beta-estradiol and curcumin) with associated changes in BCRP efflux transport function further confirmed in both cell lines.	naringin	73-81	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	167-171
27771282-7	2017	These findings establish the regulatory role AhR of in controlling BCRP expression at the BBB and confirm quercetin, naringin, 17-beta-estradiol, and curcumin as novel inducers and down-regulators of BCRP gene, protein expression and functional transporter activity and hence potential novel target sites and candidates for enhancing CNS drug delivery.	naringin	117-125	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	200-204
27904711-2	2016	In this study, we explored whether naringin could promote osteogenic differentiation of BMSCs by upregulating Foxc2 expression via the Indian hedgehog (IHH) signaling pathway.	naringin	35-43	forkhead box C2	Homo sapiens	110-115
27125297-0	2017	Naringin suppresses the development of glioblastoma by inhibiting FAK activity.	naringin	0-8	protein tyrosine kinase 2	Homo sapiens	66-69
27125297-5	2017	Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway.	naringin	26-34	protein tyrosine kinase 2	Homo sapiens	80-83
27125297-5	2017	Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway.	naringin	26-34	cyclin D1	Homo sapiens	84-93
27125297-5	2017	Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway.	naringin	26-34	protein tyrosine kinase 2	Homo sapiens	146-149
27125297-5	2017	Our study showed out that naringin can inhibit cell proliferation by inhibiting FAK/cyclin D1 pathway, promote cell apoptosis through influencing FAK/bads pathway, at the same time, it can also inhibit cell invasion and metastasis by inhibiting the FAK/mmps pathway.	naringin	26-34	protein tyrosine kinase 2	Homo sapiens	146-149
27496642-5	2016	Treatment with either naringin or glibenclamide significantly reduced lipid peroxidation, Superoxide Dismutase (SOD) activities and also increased glutathione (GSH) and ATP levels in the cells that were treated with PIs.	naringin	22-30	superoxide dismutase 1	Homo sapiens	90-110
27496642-5	2016	Treatment with either naringin or glibenclamide significantly reduced lipid peroxidation, Superoxide Dismutase (SOD) activities and also increased glutathione (GSH) and ATP levels in the cells that were treated with PIs.	naringin	22-30	superoxide dismutase 1	Homo sapiens	112-115
27496642-6	2016	Furthermore, naringin or glibenclamide significantly reduced caspase-3 and caspase-9 activities in cells that were treated with PIs.	naringin	13-21	caspase 3	Homo sapiens	61-70
27496642-6	2016	Furthermore, naringin or glibenclamide significantly reduced caspase-3 and caspase-9 activities in cells that were treated with PIs.	naringin	13-21	caspase 9	Homo sapiens	75-84
28668949-13	2017	NGN administration also attenuated the nitro-OS and restored tumor necrosis factor-alpha and endogenous antioxidant levels.	naringin	0-3	tumor necrosis factor	Rattus norvegicus	61-88
27760293-11	2016	Molecular simulation results suggest that naringin could reduce the dissociation of SOD1 dimers through direct interaction with the dimer interface.	naringin	42-50	superoxide dismutase 1	Homo sapiens	84-88
27836465-8	2016	In addition, naringin supplementation reverted back the pathological changes of liver, brain and kidney tissues, the expressions of Glutamine synthetase (GS), Na+/K+-ATPase, neuronal nitric oxide (nNOS) and soluble guanylate cyclase (sGC) in hyperammonemic rats.	naringin	13-21	glutamate-ammonia ligase	Rattus norvegicus	132-152
27836465-8	2016	In addition, naringin supplementation reverted back the pathological changes of liver, brain and kidney tissues, the expressions of Glutamine synthetase (GS), Na+/K+-ATPase, neuronal nitric oxide (nNOS) and soluble guanylate cyclase (sGC) in hyperammonemic rats.	naringin	13-21	nitric oxide synthase 1	Rattus norvegicus	197-201
27836465-8	2016	In addition, naringin supplementation reverted back the pathological changes of liver, brain and kidney tissues, the expressions of Glutamine synthetase (GS), Na+/K+-ATPase, neuronal nitric oxide (nNOS) and soluble guanylate cyclase (sGC) in hyperammonemic rats.	naringin	13-21	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	207-232
27836465-8	2016	In addition, naringin supplementation reverted back the pathological changes of liver, brain and kidney tissues, the expressions of Glutamine synthetase (GS), Na+/K+-ATPase, neuronal nitric oxide (nNOS) and soluble guanylate cyclase (sGC) in hyperammonemic rats.	naringin	13-21	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	234-237
27716530-5	2016	Furthermore, Naringin inhibited LPS-induced increase of TNF-alpha, IL-1beta and IL-6 activities to alleviate inflammatory response in heart.	naringin	13-21	tumor necrosis factor	Mus musculus	56-65
27716530-5	2016	Furthermore, Naringin inhibited LPS-induced increase of TNF-alpha, IL-1beta and IL-6 activities to alleviate inflammatory response in heart.	naringin	13-21	interleukin 1 beta	Mus musculus	67-75
27716530-5	2016	Furthermore, Naringin inhibited LPS-induced increase of TNF-alpha, IL-1beta and IL-6 activities to alleviate inflammatory response in heart.	naringin	13-21	interleukin 6	Mus musculus	80-84
27616636-9	2016	Naringin showed significantly greater percentage occupation of GPIIb/IIIa receptors than did naringenin (14.82+-0.81% vs. 3.90+-0.55%), and esculetin returned significantly higher values than fraxetin and coumarin (12.47+-0.97 vs. 7.53+-0.49 and 7.90+-0.69 respectively).	naringin	0-8	integrin subunit alpha 2b	Homo sapiens	63-68
27904711-2	2016	In this study, we explored whether naringin could promote osteogenic differentiation of BMSCs by upregulating Foxc2 expression via the Indian hedgehog (IHH) signaling pathway.	naringin	35-43	Indian hedgehog signaling molecule	Homo sapiens	152-155
27404051-4	2016	In addition, we reported that naringin, a bioflavonoid in citrus fruits, could exert beneficial effects, such as antiautophagic stress and antineuroinflammation, in the KA mouse model of epilepsy, even though it was unclear whether naringin might also attenuate the seizure-induced morphological changes of GCD in the DG.	naringin	30-38	Fanconi anemia, complementation group L	Mus musculus	307-310
27716835-2	2016	In the present study, we investigated naringin"s mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-alpha and high-mobility group box 1 expression in macrophages, and on death in a cecal ligation and puncture induced mouse model of sepsis.	naringin	38-46	high mobility group box 1	Mus musculus	157-182
27208552-13	2016	Naringin treatment resulted in significant inhibition of TNF-alpha, but elevated protein expressions of BMP-2, collagen II, and aggrecan.	naringin	0-8	tumor necrosis factor	Homo sapiens	57-66
27208552-13	2016	Naringin treatment resulted in significant inhibition of TNF-alpha, but elevated protein expressions of BMP-2, collagen II, and aggrecan.	naringin	0-8	bone morphogenetic protein 2	Homo sapiens	104-109
27208552-15	2016	CONCLUSION: Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-alpha and MMP3.	naringin	12-20	bone morphogenetic protein 2	Homo sapiens	190-195
27208552-15	2016	CONCLUSION: Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-alpha and MMP3.	naringin	12-20	SRY-box transcription factor 6	Homo sapiens	201-205
27208552-15	2016	CONCLUSION: Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-alpha and MMP3.	naringin	12-20	tumor necrosis factor	Homo sapiens	241-250
27208552-15	2016	CONCLUSION: Naringin effectively promotes the proliferation of degenerative human NP cells and improves the recuperation of the cells from degeneration by increasing expression of aggrecan, BMP-2, and Sox6 while inhibiting the expression of TNF-alpha and MMP3.	naringin	12-20	matrix metallopeptidase 3	Homo sapiens	255-259
27446336-9	2016	In conclusion, the present results indicated that the protective effects of naringin against AS are exerted via the induction of ossification, suppression of inflammation and oxidative stress and the downregulation of JAK2/STAT3 in mice.	naringin	76-84	Janus kinase 2	Mus musculus	218-222
27446336-9	2016	In conclusion, the present results indicated that the protective effects of naringin against AS are exerted via the induction of ossification, suppression of inflammation and oxidative stress and the downregulation of JAK2/STAT3 in mice.	naringin	76-84	signal transducer and activator of transcription 3	Mus musculus	223-228
26702935-13	2016	CONCLUSION: Naringin prevented intestinal tumorigenesis likely through a collection of activities including anti-proliferation, induction of apoptosis, modulation of GSK-3beta and APC/beta-catenin pathways and anti-inflammation.	naringin	12-20	glycogen synthase kinase 3 beta	Mus musculus	166-175
27105818-0	2016	NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.	naringin	26-34	neuraminidase 3	Homo sapiens	0-4
27105818-0	2016	NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.	naringin	26-34	epidermal growth factor receptor	Homo sapiens	83-87
27105818-8	2016	Furthermore, naringin inhibited NEU3 sialidase, a GM3 degrading glycosidase.	naringin	13-21	neuraminidase 3	Homo sapiens	32-36
27105818-10	2016	Naringin-treated cancer cells showed suppressed EGFR and ERK phosphorylation levels.	naringin	0-8	epidermal growth factor receptor	Homo sapiens	48-52
27105818-12	2016	NEU3 inhibitory effect of naringin induced GM3 accumulation in HeLa and A549 cells, leading the attenuation of EGFR/ERK signaling accompanied with a decrease in cell growth.	naringin	26-34	meltrin	Drosophila melanogaster	0-4
27105818-12	2016	NEU3 inhibitory effect of naringin induced GM3 accumulation in HeLa and A549 cells, leading the attenuation of EGFR/ERK signaling accompanied with a decrease in cell growth.	naringin	26-34	epidermal growth factor receptor	Homo sapiens	111-115
27050864-11	2016	Moreover, altered mRNA expression of hepatic farnesoid X receptor and renal injury molecule-1 (KIM-1) were significantly restored (p < 0.05) by naringin treatment.	naringin	147-155	hepatitis A virus cellular receptor 1	Rattus norvegicus	95-100
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	naringin	132-140	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-42
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	naringin	132-140	heme oxygenase 1	Rattus norvegicus	44-48
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	naringin	132-140	SMAD family member 3	Rattus norvegicus	50-56
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	naringin	132-140	transforming growth factor, beta 1	Rattus norvegicus	62-70
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	naringin	62-70	transforming growth factor, beta 1	Rattus norvegicus	133-141
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	naringin	62-70	SMAD family member 3	Rattus norvegicus	142-148
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	naringin	62-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	153-158
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	naringin	62-70	heme oxygenase 1	Rattus norvegicus	159-163
27040812-5	2016	To clarify whether naringin treatment reduces GCD, we evaluated the effects of intraperitoneal injection of naringin on GCD and activation of mammalian target of rapamycin complex 1 (mTORC1), an important regulator of GCD, following intrahippocampal injection of KA.	naringin	19-27	CREB regulated transcription coactivator 1	Mus musculus	183-189
27040812-7	2016	These results suggest that naringin treatment may help prevent epilepsy-induced hippocampal injury by inhibiting mTORC1 activation and thereby reducing GCD in the hippocampus in vivo.	naringin	27-35	CREB regulated transcription coactivator 1	Mus musculus	113-119
27040812-7	2016	These results suggest that naringin treatment may help prevent epilepsy-induced hippocampal injury by inhibiting mTORC1 activation and thereby reducing GCD in the hippocampus in vivo.	naringin	27-35	Fanconi anemia, complementation group L	Mus musculus	152-155
27107807-0	2016	In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish.	naringin	66-74	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-113
27154619-0	2016	Effects of naringin on learning and memory dysfunction induced by gp120 in rats.	naringin	11-19	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	66-71
26108947-5	2016	The compounds were ranked based on Glide extra precision docking score and five hits (curcumin, quercetin, morin, naringin and silibinin) were selected on the basis of their interaction with active site amino acid residues of GLO-I.	naringin	114-122	glyoxalase I	Homo sapiens	226-231
26702935-13	2016	CONCLUSION: Naringin prevented intestinal tumorigenesis likely through a collection of activities including anti-proliferation, induction of apoptosis, modulation of GSK-3beta and APC/beta-catenin pathways and anti-inflammation.	naringin	12-20	catenin (cadherin associated protein), beta 1	Mus musculus	184-196
26908354-4	2016	The expressions of interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interleukin-8 (IL-8) and cyclooxygenase-2 (COX-2) in HaCaT cells pretreated with naringin were decreased compared with the only UVB group.	naringin	152-160	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
27323041-0	2016	Protective effects of naringin against gp120-induced injury mediated by P2X7 receptors in BV2 microglial cells.	naringin	22-30	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	72-76
26908354-7	2016	In vivo, topical treatments with naringin prevented the increase of epidermal thickness, IL-6 production, cell apoptosis and the overexpression of COX-2 in BALB/c mice skin irradiated with UVB.	naringin	33-41	interleukin 6	Mus musculus	89-93
26908354-7	2016	In vivo, topical treatments with naringin prevented the increase of epidermal thickness, IL-6 production, cell apoptosis and the overexpression of COX-2 in BALB/c mice skin irradiated with UVB.	naringin	33-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
26908354-9	2016	CONCLUSION: Naringin can effectively protect against UVB-induced keratinocyte apoptosis and skin damage by inhibiting ROS production, COX-2 overexpression and strong inflammation reactions.	naringin	12-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	134-139
27109829-2	2016	The present study explores whether naringin can prevent disuse osteoporosis induced by unilateral sciatic neurectomy (USN) and whether the Semaphorin 3A-induced Wnt/beta-catenin signalling pathway is involved in the osteoprotection of naringin.	naringin	235-243	semaphorin 3A	Rattus norvegicus	139-152
27279986-11	2016	Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-alpha, IL-1beta, and IL-6 compared with the STZ group in the hippocampus.	naringin	10-18	tumor necrosis factor	Rattus norvegicus	100-109
27279986-11	2016	Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-alpha, IL-1beta, and IL-6 compared with the STZ group in the hippocampus.	naringin	10-18	interleukin 1 beta	Rattus norvegicus	111-119
27279986-11	2016	Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF-alpha, IL-1beta, and IL-6 compared with the STZ group in the hippocampus.	naringin	10-18	interleukin 6	Rattus norvegicus	125-129
26967518-2	2016	The effects of naringin on hyperglycemia-induced myocardial fibrotic changes and its putative effects on PKC-beta and p38 protein expression in type 1 rat model of diabetes are hereby investigated.	naringin	15-23	mitogen activated protein kinase 14	Rattus norvegicus	118-121
26967518-9	2016	CONCLUSIONS: Naringin"s amelioration of myocardial fibrosis by modulating p38 and PKC-beta protein expression possibly through its known antioxidant actions and may therefore be useful in retarding the progression of fibrosis in a diabetic heart.	naringin	13-21	mitogen activated protein kinase 14	Rattus norvegicus	74-77
26967518-9	2016	CONCLUSIONS: Naringin"s amelioration of myocardial fibrosis by modulating p38 and PKC-beta protein expression possibly through its known antioxidant actions and may therefore be useful in retarding the progression of fibrosis in a diabetic heart.	naringin	13-21	protein kinase C, beta	Rattus norvegicus	82-90
26474590-0	2016	Naringin inhibits the invasion and migration of human glioblastoma cell via downregulation of MMP-2 and MMP-9 expression and inactivation of p38 signaling pathway.	naringin	0-8	matrix metallopeptidase 2	Homo sapiens	94-99
26474590-0	2016	Naringin inhibits the invasion and migration of human glioblastoma cell via downregulation of MMP-2 and MMP-9 expression and inactivation of p38 signaling pathway.	naringin	0-8	matrix metallopeptidase 9	Homo sapiens	104-109
26474590-0	2016	Naringin inhibits the invasion and migration of human glioblastoma cell via downregulation of MMP-2 and MMP-9 expression and inactivation of p38 signaling pathway.	naringin	0-8	mitogen-activated protein kinase 14	Homo sapiens	141-144
26474590-11	2016	These data suggest that naringin may have therapeutic potential for controlling invasiveness of malignant gliomas by inhibiting of p38 signal transduction pathways.	naringin	24-32	mitogen-activated protein kinase 14	Homo sapiens	131-134
26476533-6	2016	In summary, we demonstrated that naringin inhibits the malignant phenotype of A375 cells by suppressing c-Src and its downstream signaling pathway.	naringin	33-41	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-109
26476533-7	2016	More importantly, we provide the novel mechanism that, as a natural inhibitor of c-Src, naringin could be an effective candidate for the treatment of melanoma.	naringin	88-96	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-86
26861272-0	2016	The Anti-Atherosclerotic Effect of Naringin Is Associated with Reduced Expressions of Cell Adhesion Molecules and Chemokines through NF-kappaB Pathway.	naringin	35-43	nuclear factor kappa B subunit 1	Homo sapiens	133-142
26920847-10	2016	Flow cytometry studies demonstrated that naringin substantially inhibited Th2 cells and enhanced Th1 cells.	naringin	41-49	heart and neural crest derivatives expressed 2	Mus musculus	74-77
26920847-10	2016	Flow cytometry studies demonstrated that naringin substantially inhibited Th2 cells and enhanced Th1 cells.	naringin	41-49	negative elongation factor complex member C/D, Th1l	Mus musculus	97-100
26861272-2	2016	The aim of this study is to investigate the impact of naringin on the TNF-alpha-induced expressions of cell adhesion molecules, chemokines and NF-kappaB signaling pathway in human umbilical vein endothelial cells (HUVECs).	naringin	54-62	tumor necrosis factor	Homo sapiens	70-79
27004375-5	2016	The effects of naringin were achieved via modulating NF-kappaB and ERK signaling pathways.	naringin	15-23	mitogen-activated protein kinase 1	Homo sapiens	67-70
26861272-2	2016	The aim of this study is to investigate the impact of naringin on the TNF-alpha-induced expressions of cell adhesion molecules, chemokines and NF-kappaB signaling pathway in human umbilical vein endothelial cells (HUVECs).	naringin	54-62	nuclear factor kappa B subunit 1	Homo sapiens	143-152
26861272-6	2016	Naringin significantly inhibited TNF-alpha-induced nuclear translocation of NF-kappaB, which resulted from the inhibited phosphorylation of IKKalpha/beta, IkappaB-alpha and NF-kappaB.	naringin	0-8	tumor necrosis factor	Homo sapiens	33-42
26861272-6	2016	Naringin significantly inhibited TNF-alpha-induced nuclear translocation of NF-kappaB, which resulted from the inhibited phosphorylation of IKKalpha/beta, IkappaB-alpha and NF-kappaB.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	76-85
26861272-6	2016	Naringin significantly inhibited TNF-alpha-induced nuclear translocation of NF-kappaB, which resulted from the inhibited phosphorylation of IKKalpha/beta, IkappaB-alpha and NF-kappaB.	naringin	0-8	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	140-153
26861272-6	2016	Naringin significantly inhibited TNF-alpha-induced nuclear translocation of NF-kappaB, which resulted from the inhibited phosphorylation of IKKalpha/beta, IkappaB-alpha and NF-kappaB.	naringin	0-8	NFKB inhibitor alpha	Homo sapiens	155-168
26861272-6	2016	Naringin significantly inhibited TNF-alpha-induced nuclear translocation of NF-kappaB, which resulted from the inhibited phosphorylation of IKKalpha/beta, IkappaB-alpha and NF-kappaB.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	173-182
26861272-7	2016	Altogether, we proposed that naringin modulated TNF-alpha-induced expressions of cell adhesion molecules and chemokines through the inhibition of TNF-alpha-induced activation of IKK/NF-kappaB signaling pathway to exert the anti-atherosclerotic effect.	naringin	29-37	tumor necrosis factor	Homo sapiens	48-57
26861272-7	2016	Altogether, we proposed that naringin modulated TNF-alpha-induced expressions of cell adhesion molecules and chemokines through the inhibition of TNF-alpha-induced activation of IKK/NF-kappaB signaling pathway to exert the anti-atherosclerotic effect.	naringin	29-37	tumor necrosis factor	Homo sapiens	146-155
26861272-7	2016	Altogether, we proposed that naringin modulated TNF-alpha-induced expressions of cell adhesion molecules and chemokines through the inhibition of TNF-alpha-induced activation of IKK/NF-kappaB signaling pathway to exert the anti-atherosclerotic effect.	naringin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	182-191
26421421-0	2016	Naringin Mitigates Cardiac Hypertrophy by Reducing Oxidative Stress and Inactivating c-Jun Nuclear Kinase-1 Protein in Type I Diabetes.	naringin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	85-105
26421421-8	2016	Naringin treatment of diabetic rats significantly reversed oxidative stress, lipid peroxidation, proteins oxidation, CH indices, and JNK protein activation compared with untreated diabetic animals.	naringin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	133-136
26721195-0	2016	Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma.	naringin	0-8	matrix metallopeptidase 2	Homo sapiens	85-90
26721195-0	2016	Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma.	naringin	0-8	matrix metallopeptidase 9	Homo sapiens	95-100
26721195-0	2016	Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma.	naringin	0-8	mitogen-activated protein kinase 1	Homo sapiens	128-131
26721195-0	2016	Naringin suppresses cell metastasis and the expression of matrix metalloproteinases (MMP-2 and MMP-9) via the inhibition of ERK-P38-JNK signaling pathway in human glioblastoma.	naringin	0-8	mitogen-activated protein kinase 8	Homo sapiens	132-135
26721195-6	2016	Furthermore, naringin was able to reduce the protein phosphorylation of extracellular signal-regulated kinase ERK, p38 mitogen-activated protein kinase and c-Jun N-terminal kinase by western blotting.	naringin	13-21	mitogen-activated protein kinase 1	Homo sapiens	110-113
26721195-6	2016	Furthermore, naringin was able to reduce the protein phosphorylation of extracellular signal-regulated kinase ERK, p38 mitogen-activated protein kinase and c-Jun N-terminal kinase by western blotting.	naringin	13-21	mitogen-activated protein kinase 1	Homo sapiens	115-118
26721195-7	2016	Collectively, our data showed that naringin attenuated the MAPK signaling pathways including ERK, JNK and p38 and resulted in the downregulation of the expression and enzymatic activities of MMP-2, MMP-9, contributing to the inhibition of metastasis in U87 cells.	naringin	35-43	mitogen-activated protein kinase 1	Homo sapiens	59-63
26721195-7	2016	Collectively, our data showed that naringin attenuated the MAPK signaling pathways including ERK, JNK and p38 and resulted in the downregulation of the expression and enzymatic activities of MMP-2, MMP-9, contributing to the inhibition of metastasis in U87 cells.	naringin	35-43	mitogen-activated protein kinase 1	Homo sapiens	93-96
26721195-7	2016	Collectively, our data showed that naringin attenuated the MAPK signaling pathways including ERK, JNK and p38 and resulted in the downregulation of the expression and enzymatic activities of MMP-2, MMP-9, contributing to the inhibition of metastasis in U87 cells.	naringin	35-43	mitogen-activated protein kinase 8	Homo sapiens	98-101
26721195-7	2016	Collectively, our data showed that naringin attenuated the MAPK signaling pathways including ERK, JNK and p38 and resulted in the downregulation of the expression and enzymatic activities of MMP-2, MMP-9, contributing to the inhibition of metastasis in U87 cells.	naringin	35-43	mitogen-activated protein kinase 1	Homo sapiens	106-109
26721195-7	2016	Collectively, our data showed that naringin attenuated the MAPK signaling pathways including ERK, JNK and p38 and resulted in the downregulation of the expression and enzymatic activities of MMP-2, MMP-9, contributing to the inhibition of metastasis in U87 cells.	naringin	35-43	matrix metallopeptidase 2	Homo sapiens	191-196
26721195-7	2016	Collectively, our data showed that naringin attenuated the MAPK signaling pathways including ERK, JNK and p38 and resulted in the downregulation of the expression and enzymatic activities of MMP-2, MMP-9, contributing to the inhibition of metastasis in U87 cells.	naringin	35-43	matrix metallopeptidase 9	Homo sapiens	198-203
26612654-8	2016	Adminstration of naringin at different doses (25, 50 and 100 mg/kg) was able to protect against the deterioration in kidney function, abrogate the decline in antioxidant enzyme activities and suppressed the increase in TBARS, nitrite and TNF-alpha concentrations.	naringin	17-25	tumor necrosis factor	Rattus norvegicus	238-247
26612654-9	2016	Moreover, naringin inhibited NF-kappaB and iNOS pathways, caspase-3 and p53 activation and improved the histological changes induced by cisplatin.	naringin	10-18	nitric oxide synthase 2	Rattus norvegicus	43-47
26612654-9	2016	Moreover, naringin inhibited NF-kappaB and iNOS pathways, caspase-3 and p53 activation and improved the histological changes induced by cisplatin.	naringin	10-18	caspase 3	Rattus norvegicus	58-67
26612654-9	2016	Moreover, naringin inhibited NF-kappaB and iNOS pathways, caspase-3 and p53 activation and improved the histological changes induced by cisplatin.	naringin	10-18	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	72-75
26433966-10	2016	Finally, naringin and narirutin from naringenin-7-O-glucoside were produced using the engineered fission yeast expressing the AtRHM2 and the Cm1,2RhaT or the Cs1,6RhaT genes as a whole-cell-biocatalyst.	naringin	9-17	NAD-dependent epimerase/dehydratase family protein	Arabidopsis thaliana	126-132
27509965-10	2016	In conclusion, naringin induces human hepatocellular carcinoma HepG2 cell apoptosis via mitochondriamediated activation of caspase9 and caspase8mediated proteolysis of Bid.	naringin	15-23	caspase 9	Homo sapiens	123-131
27509965-10	2016	In conclusion, naringin induces human hepatocellular carcinoma HepG2 cell apoptosis via mitochondriamediated activation of caspase9 and caspase8mediated proteolysis of Bid.	naringin	15-23	caspase 8	Homo sapiens	136-144
27509965-10	2016	In conclusion, naringin induces human hepatocellular carcinoma HepG2 cell apoptosis via mitochondriamediated activation of caspase9 and caspase8mediated proteolysis of Bid.	naringin	15-23	BH3 interacting domain death agonist	Homo sapiens	168-171
26884798-9	2016	In the current study, we found that naringin could synergistically enhance the action of 1alpha,25-dihydroxyvitamin D3 in promoting the secretion of osteoprotegerin by osteoblasts in vitro.	naringin	36-44	TNF receptor superfamily member 11b	Homo sapiens	149-164
26977316-9	2016	Naringin at a dose of 80 mg/kg body weight significantly decreased TNF-alpha and IL-1beta activity, hydroxyproline content, and MDA level (p < 0.01) and increased GPx and SOD activities (p < 0.05).	naringin	0-8	tumor necrosis factor	Rattus norvegicus	67-76
26977316-9	2016	Naringin at a dose of 80 mg/kg body weight significantly decreased TNF-alpha and IL-1beta activity, hydroxyproline content, and MDA level (p < 0.01) and increased GPx and SOD activities (p < 0.05).	naringin	0-8	interleukin 1 beta	Rattus norvegicus	81-89
26482937-8	2015	Also, in the presence of Wnt inhibitor DKK-1, naringin is no longer effective in stimulating ALP activity, increasing calcium content and mRNA expression levels of RUNX2 and OSX in H2O2-exposed hADMSCs.	naringin	46-54	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	39-44
27069482-6	2016	We found that naringin dose-dependently increased ALP activity and Alizarin red S staining, and treatment at the optimal concentration (50 mug/mL) increased mRNA levels of osteogenic genes and Notch1 expression, while decreasing PPARgamma2 mRNA levels.	naringin	14-22	notch receptor 1	Rattus norvegicus	193-199
26541456-5	2015	In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/beta-catenin signaling pathways.	naringin	15-23	periostin	Rattus norvegicus	114-123
26541456-5	2015	In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/beta-catenin signaling pathways.	naringin	15-23	catenin beta 1	Rattus norvegicus	199-211
26482937-8	2015	Also, in the presence of Wnt inhibitor DKK-1, naringin is no longer effective in stimulating ALP activity, increasing calcium content and mRNA expression levels of RUNX2 and OSX in H2O2-exposed hADMSCs.	naringin	46-54	RUNX family transcription factor 2	Homo sapiens	164-169
26482937-8	2015	Also, in the presence of Wnt inhibitor DKK-1, naringin is no longer effective in stimulating ALP activity, increasing calcium content and mRNA expression levels of RUNX2 and OSX in H2O2-exposed hADMSCs.	naringin	46-54	Sp7 transcription factor	Homo sapiens	174-177
26032685-8	2015	Our findings provide a molecular basis by which naringin restores the TNF-alpha-induced damage in MSCs and provide novel insights into the application of naringin in the MSC-based treatments for inflammation-induced bone injury.	naringin	48-56	tumor necrosis factor	Homo sapiens	70-79
25939427-8	2015	Moreover, naringin significantly enhanced insulin signaling pathway as indicated by a 34.5% increase in the expression levels of IRS-1, a 47.8% decrease in the p-IRS-1, a 1.43-fold increase in the p-Akt, and a 1.89-fold increase in the p-GSK-3beta in the hippocampus of the HFDN mice versus HFD mice.	naringin	10-18	insulin receptor substrate 1	Mus musculus	129-134
25939427-8	2015	Moreover, naringin significantly enhanced insulin signaling pathway as indicated by a 34.5% increase in the expression levels of IRS-1, a 47.8% decrease in the p-IRS-1, a 1.43-fold increase in the p-Akt, and a 1.89-fold increase in the p-GSK-3beta in the hippocampus of the HFDN mice versus HFD mice.	naringin	10-18	insulin receptor substrate 1	Mus musculus	162-167
25939427-8	2015	Moreover, naringin significantly enhanced insulin signaling pathway as indicated by a 34.5% increase in the expression levels of IRS-1, a 47.8% decrease in the p-IRS-1, a 1.43-fold increase in the p-Akt, and a 1.89-fold increase in the p-GSK-3beta in the hippocampus of the HFDN mice versus HFD mice.	naringin	10-18	glycogen synthase kinase 3 beta	Mus musculus	238-247
26201693-0	2015	Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	81-84
26201693-0	2015	Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	85-89
26280522-0	2015	Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells.	naringin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	122-126
26280522-10	2015	Further, naringin enhances the nuclear translocation of Nrf2 and induces the NAD(P)H: quinone oxidoreductase-1 and Heme oxygenase-1 expressions through the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.	naringin	9-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	56-60
26280522-10	2015	Further, naringin enhances the nuclear translocation of Nrf2 and induces the NAD(P)H: quinone oxidoreductase-1 and Heme oxygenase-1 expressions through the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.	naringin	9-17	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	77-131
26280522-10	2015	Further, naringin enhances the nuclear translocation of Nrf2 and induces the NAD(P)H: quinone oxidoreductase-1 and Heme oxygenase-1 expressions through the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.	naringin	9-17	AKT serine/threonine kinase 1	Rattus norvegicus	193-196
26280522-11	2015	Taken together, the above findings suggest that naringin augments cellular antioxidant defense capacity and reduces the 3-NP-induced neurotoxicity in PC12 cells through the PI-3K/Akt-dependent Nrf2 activation in PC12 cells.	naringin	48-56	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
26280522-11	2015	Taken together, the above findings suggest that naringin augments cellular antioxidant defense capacity and reduces the 3-NP-induced neurotoxicity in PC12 cells through the PI-3K/Akt-dependent Nrf2 activation in PC12 cells.	naringin	48-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	193-197
26300349-10	2015	In addition, naringin activated the protein expression of PPARgamma, and administration of the PPARgamma inhibitor decreased the protein expression of PPARgamma, and attenuated the effects of naringin on cognitive deficit.	naringin	13-21	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	58-67
26300349-12	2015	These results suggested that naringin ameliorated cognitive deficits via oxidative stress, proinflammatory factors and the PPARgamma signaling pathway in the type 2 diabetic rat model.	naringin	29-37	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	123-132
26120027-0	2015	Protective role of naringin against cisplatin induced oxidative stress, inflammatory response and apoptosis in rat striatum via suppressing ROS-mediated NF-kappaB and P53 signaling pathways.	naringin	19-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	167-170
26120027-10	2015	Naringin (25, 50 and 100mg/kg) administration was able to protect against deterioration in striatum tissue, abrogate the change in antioxidant enzyme activities and suppressed the increase in MDA, PCO, NO and TNF-alpha concentrations.	naringin	0-8	tumor necrosis factor	Rattus norvegicus	209-218
26126997-2	2015	Previous studies have demonstrated that naringin improves the activity levels of osteocalcin (OC) and alkaline phosphatase (ALP) in MC3T3-E1 osteoblast precursor cells.	naringin	40-48	bone gamma-carboxyglutamate protein 2	Mus musculus	81-92
26126997-2	2015	Previous studies have demonstrated that naringin improves the activity levels of osteocalcin (OC) and alkaline phosphatase (ALP) in MC3T3-E1 osteoblast precursor cells.	naringin	40-48	bone gamma-carboxyglutamate protein 2	Mus musculus	94-96
26126997-9	2015	To our knowledge, this is the first study to report naringin-induced osteogenesis via upregulation of the expression levels of miR-20a, and downregulation of the expression levels of PPARgamma.	naringin	52-60	microRNA 20a	Mus musculus	127-134
26126997-9	2015	To our knowledge, this is the first study to report naringin-induced osteogenesis via upregulation of the expression levels of miR-20a, and downregulation of the expression levels of PPARgamma.	naringin	52-60	peroxisome proliferator activated receptor gamma	Mus musculus	183-192
26147673-6	2015	Addition of Naringin (100 muM) showed approximately 40% reduction in protein glycation in vitro.	naringin	12-20	latexin	Homo sapiens	26-29
25896911-0	2015	Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and iNOS Signaling Pathways in Hippocampus of Aged Rats.	naringin	0-8	acetylcholinesterase	Rattus norvegicus	115-119
25117567-0	2015	Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-kappab, STAT3 and pro-inflammatory mediators and enhancement of IkappaBalpha and anti-inflammatory cytokines.	naringin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
25773745-12	2015	Therefore, Nar provided cardioprotection by inducing the phosphorylation of ERK1/2, PKCdelta, and AKT, which subsequently activated Nrf2 and its downstream genes.	naringin	11-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	132-136
25812588-0	2015	Naringin inhibits gamma radiation-induced oxidative DNA damage and inflammation, by modulating p53 and NF-kappaB signaling pathways in murine splenocytes.	naringin	0-8	transformation related protein 53, pseudogene	Mus musculus	95-98
25812588-0	2015	Naringin inhibits gamma radiation-induced oxidative DNA damage and inflammation, by modulating p53 and NF-kappaB signaling pathways in murine splenocytes.	naringin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
25812588-8	2015	The results also demonstrated that NG blocked the IR-induced p38 function and reversed IR-mediated differential stress response through inhibition of the NF-kappaB pathway.	naringin	35-37	mitogen-activated protein kinase 14	Mus musculus	61-64
25812588-8	2015	The results also demonstrated that NG blocked the IR-induced p38 function and reversed IR-mediated differential stress response through inhibition of the NF-kappaB pathway.	naringin	35-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	154-163
25812588-10	2015	However, NG pretreatment reversed the inflammatory development through downregulation of NF-kappaB, and regulated the expression of CRP, MCP-1, and iNOS2.	naringin	9-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
25812588-10	2015	However, NG pretreatment reversed the inflammatory development through downregulation of NF-kappaB, and regulated the expression of CRP, MCP-1, and iNOS2.	naringin	9-11	C-reactive protein, pentraxin-related	Mus musculus	132-135
25812588-10	2015	However, NG pretreatment reversed the inflammatory development through downregulation of NF-kappaB, and regulated the expression of CRP, MCP-1, and iNOS2.	naringin	9-11	mast cell protease 1	Mus musculus	137-142
25117567-9	2015	Western blot analyses revealed increased protein expression of NF-kappaB, STAT3 and COX-2 and decreased IkappaBalpha in response to Cg treatment, which were reversed by the treatment with naringin.	naringin	188-196	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
25117567-9	2015	Western blot analyses revealed increased protein expression of NF-kappaB, STAT3 and COX-2 and decreased IkappaBalpha in response to Cg treatment, which were reversed by the treatment with naringin.	naringin	188-196	signal transducer and activator of transcription 3	Mus musculus	74-79
25117567-9	2015	Western blot analyses revealed increased protein expression of NF-kappaB, STAT3 and COX-2 and decreased IkappaBalpha in response to Cg treatment, which were reversed by the treatment with naringin.	naringin	188-196	cytochrome c oxidase II, mitochondrial	Mus musculus	84-89
25117567-0	2015	Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-kappab, STAT3 and pro-inflammatory mediators and enhancement of IkappaBalpha and anti-inflammatory cytokines.	naringin	0-8	signal transducer and activator of transcription 3	Mus musculus	116-121
25117567-9	2015	Western blot analyses revealed increased protein expression of NF-kappaB, STAT3 and COX-2 and decreased IkappaBalpha in response to Cg treatment, which were reversed by the treatment with naringin.	naringin	188-196	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	104-116
25117567-0	2015	Naringin attenuates the development of carrageenan-induced acute lung inflammation through inhibition of NF-kappab, STAT3 and pro-inflammatory mediators and enhancement of IkappaBalpha and anti-inflammatory cytokines.	naringin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	172-184
25499067-8	2015	The more robust recruitment of 53BP1 was correlated with lower DNA and chromosomal damage after naringin and hesperidin treatment compared with diosmin treatment.	naringin	96-104	tumor protein p53 binding protein 1	Homo sapiens	31-36
25767683-6	2015	The phosphorylation of PLCgamma and Akt was significantly inhibited by YE, heperidin and naringin.	naringin	89-97	AKT serine/threonine kinase 1	Homo sapiens	36-39
25767683-8	2015	The results from this study suggest that YE, hesperidin and naringin can inhibit human platelet aggregation, at least partly through the inhibition of PLCgamma and Akt, leading to a decrease in TXB2 formation and granule secretion.	naringin	60-68	AKT serine/threonine kinase 1	Homo sapiens	164-167
25773745-0	2015	Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91
25773745-9	2015	Moreover, the presence of Nar alone in H9c2 cells increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, as well as consistently increased the protein levels of heme oxygenase (HO-1) and glutamate cysteine ligase (GCLC).	naringin	26-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
25773745-9	2015	Moreover, the presence of Nar alone in H9c2 cells increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, as well as consistently increased the protein levels of heme oxygenase (HO-1) and glutamate cysteine ligase (GCLC).	naringin	26-29	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	241-245
25773745-12	2015	Therefore, Nar provided cardioprotection by inducing the phosphorylation of ERK1/2, PKCdelta, and AKT, which subsequently activated Nrf2 and its downstream genes.	naringin	11-14	mitogen activated protein kinase 3	Rattus norvegicus	76-82
25773745-12	2015	Therefore, Nar provided cardioprotection by inducing the phosphorylation of ERK1/2, PKCdelta, and AKT, which subsequently activated Nrf2 and its downstream genes.	naringin	11-14	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
25818985-0	2015	Naringin attenuates the cytotoxicity of hepatotoxin microcystin-LR by the curious mechanisms to OATP1B1- and OATP1B3-expressing cells.	naringin	0-8	solute carrier organic anion transporter family member 1B3	Homo sapiens	109-116
25818985-7	2015	In addition, uptake of microcystin-LR into HEK293-OATP1B3 cells was inhibited by naringin.	naringin	81-89	solute carrier organic anion transporter family member 1B3	Homo sapiens	50-57
26038697-6	2015	Our in silico study suggests that not only small molecules such as adenosine derivatives but also bulky molecules like naringin can be a potent ADA1 inhibitor for the clinical usage.	naringin	119-127	transcriptional adaptor 1	Homo sapiens	144-148
25466967-11	2015	TC was taken up into HBU cells (Km = 18.5 +- 4.8 mumol/L; Vmax = 106 +- 11.3 pmol/mg min) by mechanisms that could be synergistically inhibited by naringin (IC50 = 10.8 (8.4; 13.8) mumol/L) and verapamil (IC50 = 4.6 (2.8; 7.5) mumol/L), inhibitors of OATP1A2 and OCT1, respectively.	naringin	147-155	solute carrier organic anion transporter family member 1A2	Homo sapiens	251-258
25466967-11	2015	TC was taken up into HBU cells (Km = 18.5 +- 4.8 mumol/L; Vmax = 106 +- 11.3 pmol/mg min) by mechanisms that could be synergistically inhibited by naringin (IC50 = 10.8 (8.4; 13.8) mumol/L) and verapamil (IC50 = 4.6 (2.8; 7.5) mumol/L), inhibitors of OATP1A2 and OCT1, respectively.	naringin	147-155	solute carrier family 22 member 1	Homo sapiens	263-267
26159568-4	2015	RESULTS: Naringin promoted the mRNA and protein expressions of beta-catenin, and improved Ser552 phosphorylation on beta-catenin in UMR-106 cells, which leads to the activation of lymphoid enhancer factor (LEF)/ T-cell factor (TCF) transcription factors.	naringin	9-17	catenin beta 1	Rattus norvegicus	63-75
26159568-4	2015	RESULTS: Naringin promoted the mRNA and protein expressions of beta-catenin, and improved Ser552 phosphorylation on beta-catenin in UMR-106 cells, which leads to the activation of lymphoid enhancer factor (LEF)/ T-cell factor (TCF) transcription factors.	naringin	9-17	catenin beta 1	Rattus norvegicus	116-128
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	68-96
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	98-102
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	catenin beta 1	Rattus norvegicus	166-178
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	catenin beta 1	Rattus norvegicus	226-238
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	154-162	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	262-266
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	207-215	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	207-215	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	68-96
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	207-215	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	98-102
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	207-215	catenin beta 1	Rattus norvegicus	166-178
26159568-5	2015	The recruitments of protein kinase B (Akt) inhibitor (Akti-1/2) and AMP-activated protein kinase (AMPK) inhibitor (Dorsomorphin) reduced the influence of naringin on beta-catenin phosphorylation, suggesting naringin activates beta-catenin via regulating Akt and AMPK.	naringin	207-215	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
26080564-7	2015	RESULT: Naringin could inhibit osteoclast differentiation, bone absorption function and proliferation activity of osteoclasts, significantly down-regulate RANK, TRAP, MMP-9 and NFATc1 mRNA expressions in the osteoclast differentiation process, and up-regulate the C-fos mRNA expression.	naringin	8-16	matrix metallopeptidase 9	Mus musculus	167-172
26124853-6	2015	Moreover, naringin treatment protected hippocampal CA1 neurons in the KA-treated hippocampus, ameliorated KA-induced autophagic stress, confirmed by the expression of microtubule-associated protein light chain 3 (LC3), and attenuated an increase in tumor necrosis factor-alpha (TNFalpha) in activated microglia.	naringin	10-18	carbonic anhydrase 1	Mus musculus	51-54
26124853-6	2015	Moreover, naringin treatment protected hippocampal CA1 neurons in the KA-treated hippocampus, ameliorated KA-induced autophagic stress, confirmed by the expression of microtubule-associated protein light chain 3 (LC3), and attenuated an increase in tumor necrosis factor-alpha (TNFalpha) in activated microglia.	naringin	10-18	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	213-216
26124853-6	2015	Moreover, naringin treatment protected hippocampal CA1 neurons in the KA-treated hippocampus, ameliorated KA-induced autophagic stress, confirmed by the expression of microtubule-associated protein light chain 3 (LC3), and attenuated an increase in tumor necrosis factor-alpha (TNFalpha) in activated microglia.	naringin	10-18	tumor necrosis factor	Mus musculus	249-276
26124853-6	2015	Moreover, naringin treatment protected hippocampal CA1 neurons in the KA-treated hippocampus, ameliorated KA-induced autophagic stress, confirmed by the expression of microtubule-associated protein light chain 3 (LC3), and attenuated an increase in tumor necrosis factor-alpha (TNFalpha) in activated microglia.	naringin	10-18	tumor necrosis factor	Mus musculus	278-286
26337322-11	2015	In conclusion, naringin treatment ameliorates arsenic-induced renal and hepatic damage in rats due its antioxidant and anti-inflammatory properties via down-regulation of elevated oxido-nitrosative stress, KIM-1, Caspase-3, TGF-beta, and TNF-alpha levels.	naringin	15-23	hepatitis A virus cellular receptor 1	Rattus norvegicus	206-211
26337322-11	2015	In conclusion, naringin treatment ameliorates arsenic-induced renal and hepatic damage in rats due its antioxidant and anti-inflammatory properties via down-regulation of elevated oxido-nitrosative stress, KIM-1, Caspase-3, TGF-beta, and TNF-alpha levels.	naringin	15-23	caspase 3	Rattus norvegicus	213-222
26337322-11	2015	In conclusion, naringin treatment ameliorates arsenic-induced renal and hepatic damage in rats due its antioxidant and anti-inflammatory properties via down-regulation of elevated oxido-nitrosative stress, KIM-1, Caspase-3, TGF-beta, and TNF-alpha levels.	naringin	15-23	transforming growth factor, beta 1	Rattus norvegicus	224-232
26337322-11	2015	In conclusion, naringin treatment ameliorates arsenic-induced renal and hepatic damage in rats due its antioxidant and anti-inflammatory properties via down-regulation of elevated oxido-nitrosative stress, KIM-1, Caspase-3, TGF-beta, and TNF-alpha levels.	naringin	15-23	tumor necrosis factor	Rattus norvegicus	238-247
26080564-7	2015	RESULT: Naringin could inhibit osteoclast differentiation, bone absorption function and proliferation activity of osteoclasts, significantly down-regulate RANK, TRAP, MMP-9 and NFATc1 mRNA expressions in the osteoclast differentiation process, and up-regulate the C-fos mRNA expression.	naringin	8-16	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	177-183
26080564-7	2015	RESULT: Naringin could inhibit osteoclast differentiation, bone absorption function and proliferation activity of osteoclasts, significantly down-regulate RANK, TRAP, MMP-9 and NFATc1 mRNA expressions in the osteoclast differentiation process, and up-regulate the C-fos mRNA expression.	naringin	8-16	FBJ osteosarcoma oncogene	Mus musculus	264-269
25632752-7	2014	The effect of naringin on the expression of IL-1beta-induced collagen II in CDs was detected by immunohistochemical method.	naringin	14-22	interleukin-1 beta	Oryctolagus cuniculus	44-52
25632752-8	2014	The effect of naringin on caveolin-1, p-p38, and p-ATF-2 protein in IL-1beta-induced CDs was detected by Western blot.	naringin	14-22	caveolin-1	Oryctolagus cuniculus	26-36
25632752-8	2014	The effect of naringin on caveolin-1, p-p38, and p-ATF-2 protein in IL-1beta-induced CDs was detected by Western blot.	naringin	14-22	cyclic AMP-dependent transcription factor ATF-2	Oryctolagus cuniculus	51-56
25632752-8	2014	The effect of naringin on caveolin-1, p-p38, and p-ATF-2 protein in IL-1beta-induced CDs was detected by Western blot.	naringin	14-22	interleukin-1 beta	Oryctolagus cuniculus	68-76
25752139-12	2014	Study on biotransforming kinetics showed that all the four isolated bacterial strains were able to convert naringin (0.2 mmol/L) to naringenin within 12 h. The maximal concentration of the substrate naringin that strain AUH-JLD3, strain AUH-JLD7, strain AUH-JLD104 and strain AUH-JLD109 could biotransform efficiently were 0.	naringin	107-115	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	220-223
25752139-12	2014	Study on biotransforming kinetics showed that all the four isolated bacterial strains were able to convert naringin (0.2 mmol/L) to naringenin within 12 h. The maximal concentration of the substrate naringin that strain AUH-JLD3, strain AUH-JLD7, strain AUH-JLD104 and strain AUH-JLD109 could biotransform efficiently were 0.	naringin	107-115	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	237-240
25752139-12	2014	Study on biotransforming kinetics showed that all the four isolated bacterial strains were able to convert naringin (0.2 mmol/L) to naringenin within 12 h. The maximal concentration of the substrate naringin that strain AUH-JLD3, strain AUH-JLD7, strain AUH-JLD104 and strain AUH-JLD109 could biotransform efficiently were 0.	naringin	107-115	AU RNA binding methylglutaconyl-CoA hydratase	Homo sapiens	237-240
25288222-3	2014	Hence, naringin, a bioflavonoid isolated from citrus fruits and recently identified as a natural ligand of PPAR-gamma, has begun to be evaluated for treatment of alcoholism.	naringin	7-15	peroxisome proliferator activated receptor gamma	Mus musculus	107-117
25632752-9	2014	The effect of naringin on mRNA expression of IL-1beta and TNF-alpha in IL-1beta-induced CDs was detected by RT-PCR.	naringin	14-22	interleukin-1 beta	Oryctolagus cuniculus	45-53
25632752-9	2014	The effect of naringin on mRNA expression of IL-1beta and TNF-alpha in IL-1beta-induced CDs was detected by RT-PCR.	naringin	14-22	tumor necrosis factor	Oryctolagus cuniculus	58-67
25632752-9	2014	The effect of naringin on mRNA expression of IL-1beta and TNF-alpha in IL-1beta-induced CDs was detected by RT-PCR.	naringin	14-22	interleukin-1 beta	Oryctolagus cuniculus	71-79
25632752-11	2014	Naringin could promote the proliferation of CDs, and inhibit the effect of IL-1beta on collagen II in CDs.	naringin	0-8	interleukin-1 beta	Oryctolagus cuniculus	75-83
25632752-12	2014	Compared with the model group, naringin could reduce the expression of caveolin-1, p-p38, p-ATF-2, IL-1beta, and TNF-alpha in IL-1beta induced CDs (P < 0.05), which was approximate to the level of the normal group.	naringin	31-39	caveolin-1	Oryctolagus cuniculus	71-81
25632752-12	2014	Compared with the model group, naringin could reduce the expression of caveolin-1, p-p38, p-ATF-2, IL-1beta, and TNF-alpha in IL-1beta induced CDs (P < 0.05), which was approximate to the level of the normal group.	naringin	31-39	cyclic AMP-dependent transcription factor ATF-2	Oryctolagus cuniculus	92-97
25632752-12	2014	Compared with the model group, naringin could reduce the expression of caveolin-1, p-p38, p-ATF-2, IL-1beta, and TNF-alpha in IL-1beta induced CDs (P < 0.05), which was approximate to the level of the normal group.	naringin	31-39	interleukin-1 beta	Oryctolagus cuniculus	99-107
25632752-12	2014	Compared with the model group, naringin could reduce the expression of caveolin-1, p-p38, p-ATF-2, IL-1beta, and TNF-alpha in IL-1beta induced CDs (P < 0.05), which was approximate to the level of the normal group.	naringin	31-39	tumor necrosis factor	Oryctolagus cuniculus	113-122
25632752-12	2014	Compared with the model group, naringin could reduce the expression of caveolin-1, p-p38, p-ATF-2, IL-1beta, and TNF-alpha in IL-1beta induced CDs (P < 0.05), which was approximate to the level of the normal group.	naringin	31-39	interleukin-1 beta	Oryctolagus cuniculus	126-134
25632752-13	2014	CONCLUSIONS: Naringin could not only promote the proliferation of CDs, but also protect IL-1beta-induced CDs.	naringin	13-21	interleukin-1 beta	Oryctolagus cuniculus	88-96
25174821-0	2014	Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF-kappaB/COX-2-caspase-1 pathway in HeLa cervical cancer cells.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	97-106
25593395-6	2014	In the present study, the binding potential of four flavanone glycosides such as naringin, hesperidin, poncirin and sakuranin against acetylcholinesterase was analysed by using the method of molecular modeling and docking.	naringin	81-89	acetylcholinesterase (Cartwright blood group)	Homo sapiens	134-154
25174821-0	2014	Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF-kappaB/COX-2-caspase-1 pathway in HeLa cervical cancer cells.	naringin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	107-112
24975661-8	2014	Therefore, naringin inhibits migration and invasion of human chondrosarcoma via down-regulation of VCAM-1 by increasing miR-126.	naringin	11-19	vascular cell adhesion molecule 1	Homo sapiens	99-105
24975661-8	2014	Therefore, naringin inhibits migration and invasion of human chondrosarcoma via down-regulation of VCAM-1 by increasing miR-126.	naringin	11-19	microRNA 126	Homo sapiens	120-127
24751467-3	2014	Ferulic acid, hydroxysafflor yellow A (HSYA), and naringin were confirmed to be the bioactive compounds in Huoxue capsule that specifically bound to the beta2-AR.	naringin	50-58	adrenoceptor beta 2	Homo sapiens	153-161
24947867-7	2014	The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A, and quinidine, respectively.	naringin	101-109	solute carrier organic anion transporter family member 1A2	Homo sapiens	4-11
24947867-7	2014	The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A, and quinidine, respectively.	naringin	101-109	solute carrier organic anion transporter family member 2B1	Homo sapiens	14-21
24947867-7	2014	The OATP1A2-, OATP2B1-, and OCT1-mediated quercetin uptake was inhibited by known inhibitors such as naringin, cyclosporin A, and quinidine, respectively.	naringin	101-109	solute carrier family 22 member 1	Homo sapiens	28-32
25120631-5	2014	The levels of P-selectin and platelet factor 4 (PF4) also decreased following treatment with naringin compared with those of the model group.	naringin	93-101	P-selectin	Oryctolagus cuniculus	14-24
24880026-0	2014	Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats.	naringin	0-8	myotrophin	Rattus norvegicus	129-142
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	myotrophin	Rattus norvegicus	110-123
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	transforming growth factor, beta 1	Rattus norvegicus	132-140
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	vascular endothelial growth factor C	Rattus norvegicus	145-151
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	angiogenin	Rattus norvegicus	154-159
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	tumor necrosis factor	Rattus norvegicus	226-235
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	interleukin 1 beta	Rattus norvegicus	237-245
24880026-9	2014	Naringin treatment at 40 and 80 mg/kg resulted in significant (P<0.05) up-regulation of mRNA expression of growth factor (IFG-1, TGF-beta and VEGF-c), Ang-1 and collagen-1 whereas mRNA expression of inflammatory mediators (TNF-alpha, IL-1beta and IL-6) was down-regulated.	naringin	0-8	interleukin 6	Rattus norvegicus	250-254
24751467-6	2014	beta2-AR affinity chromatography was valuable in focusing attention on the further investigation of ferulic acid, HSYA, and naringin as beta2-AR agonists.	naringin	124-132	adrenoceptor beta 2	Homo sapiens	0-8
24751467-6	2014	beta2-AR affinity chromatography was valuable in focusing attention on the further investigation of ferulic acid, HSYA, and naringin as beta2-AR agonists.	naringin	124-132	adrenoceptor beta 2	Homo sapiens	136-144
24998504-1	2014	Our previous study has demonstrated that naringin attenuates EGF-induced MUC5AC hypersecretion in A549 cells by suppressing the cooperative activities of MAPKs/AP-1 and IKKs/IkappaB/NF-kappaB signaling pathways.	naringin	41-49	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	73-79
24998504-5	2014	Moreover, the MUC5AC content in BALF and goblet-cells in large airways of LPS-induced ALI mice were significantly attenuated by dexamethasone (5 mg/kg), ambroxol (25 mg/kg), and naringin (15, 60 mg/kg).	naringin	178-186	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	14-20
24399619-0	2014	Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells.	naringin	109-117	leptin	Rattus norvegicus	18-24
24797334-0	2014	Naringin protects the nigrostriatal dopaminergic projection through induction of GDNF in a neurotoxin model of Parkinson"s disease.	naringin	0-8	glial cell derived neurotrophic factor	Rattus norvegicus	81-85
24797334-3	2014	To ascertain whether naringin-induced GDNF contributes to neuroprotection, we further investigated the effects of intranigral injection of neutralizing antibodies against GDNF in the MPP(+) rat model of PD.	naringin	21-29	glial cell derived neurotrophic factor	Rattus norvegicus	38-42
24797334-4	2014	Our observations demonstrate that naringin could increase the level of GDNF in DA neurons, contributing to neuroprotection in the MPP(+) rat model of PD, with activation of mammalian target of rapamycin complex 1.	naringin	34-42	glial cell derived neurotrophic factor	Rattus norvegicus	71-75
24797334-5	2014	Moreover, naringin could attenuate the level of tumor necrosis factor-alpha in microglia increased by MPP(+)-induced neurotoxicity in the substantia nigra.	naringin	10-18	tumor necrosis factor	Rattus norvegicus	48-75
24797334-6	2014	These results indicate that naringin could impart to DA neurons the important ability to produce GDNF as a therapeutic agent against PD with anti-inflammatory effects, suggesting that naringin is a beneficial natural product for the prevention of DA degeneration in the adult brain.	naringin	28-36	glial cell derived neurotrophic factor	Homo sapiens	97-101
24797334-6	2014	These results indicate that naringin could impart to DA neurons the important ability to produce GDNF as a therapeutic agent against PD with anti-inflammatory effects, suggesting that naringin is a beneficial natural product for the prevention of DA degeneration in the adult brain.	naringin	184-192	glial cell derived neurotrophic factor	Homo sapiens	97-101
25067902-15	2014	The significant results (p < 0.05) were obtained for freeze dried solid dispersions in the presence of P-gp inhibitor than without naringin (15 mg/kg) with an absorption enhancement of 8-fold.	naringin	134-142	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	106-110
25102867-4	2014	The effect of Naringin on BMSCs was evaluated respectively by CCK-8 method and measuring the activity of alkaline phosphatase (ALP).	naringin	14-22	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	105-125
25102867-4	2014	The effect of Naringin on BMSCs was evaluated respectively by CCK-8 method and measuring the activity of alkaline phosphatase (ALP).	naringin	14-22	alkaline phosphatase, biomineralization associated	Canis lupus familiaris	127-130
24637089-8	2014	In addition, naringin treatment significantly decreased the amount of cleaved caspase 3, Bax, and p53 protein expression and increased the Bcl-2 protein expression.	naringin	13-21	caspase 3	Rattus norvegicus	78-87
24637089-8	2014	In addition, naringin treatment significantly decreased the amount of cleaved caspase 3, Bax, and p53 protein expression and increased the Bcl-2 protein expression.	naringin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	89-92
24637089-8	2014	In addition, naringin treatment significantly decreased the amount of cleaved caspase 3, Bax, and p53 protein expression and increased the Bcl-2 protein expression.	naringin	13-21	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	98-101
24637089-8	2014	In addition, naringin treatment significantly decreased the amount of cleaved caspase 3, Bax, and p53 protein expression and increased the Bcl-2 protein expression.	naringin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	139-144
24741397-4	2014	In the current study, we investigated the question of whether naringenin and naringin could stimulate CCK secretion and then examined the mechanisms involved in CCK release.	naringin	77-85	cholecystokinin	Homo sapiens	102-105
24118820-7	2014	These injuries were significantly attenuated by the pre-treatment of cells with either naringin or SB203580 (a selective inhibitor of p38 MAPK) or U0126 (a selective inhibitor of extracellular signal regulated kinase 1/2, ERK1/2) or SP600125 (a selective inhibitor of c-jun N-termanal kinase, JNK) before exposure to HG, respectively.	naringin	87-95	mitogen activated protein kinase 14	Rattus norvegicus	134-137
24399619-0	2014	Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2 cardiac cells.	naringin	109-117	mitogen activated protein kinase 14	Rattus norvegicus	51-54
24399619-2	2014	In this study, we demonstrate that naringin, a citrus flavonone, protects cardiomyoblasts (H9c2 cells) against high glucose (HG)-induced apoptosis by modulating the activation of the p38 MAPK pathway.	naringin	35-43	mitogen activated protein kinase 14	Rattus norvegicus	183-186
24399619-3	2014	We investigated the hypothesis that naringin prevents HG-induced injury by inhibiting the leptin-induced activation of the p38 MAPK pathway in H9c2 cells.	naringin	36-44	leptin	Rattus norvegicus	90-96
24399619-3	2014	We investigated the hypothesis that naringin prevents HG-induced injury by inhibiting the leptin-induced activation of the p38 MAPK pathway in H9c2 cells.	naringin	36-44	mitogen activated protein kinase 14	Rattus norvegicus	123-126
24479689-6	2014	Moreover, an integrated in silico approach for the prediction of Phase I metabolism of the flavonoids quercetin, rutin, naringenin and naringin, which provided useful information about the most likely metabolites of these flavonoids and their interactions with amino acid residues of CYP2C9, is described.	naringin	135-143	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	284-290
24118820-7	2014	These injuries were significantly attenuated by the pre-treatment of cells with either naringin or SB203580 (a selective inhibitor of p38 MAPK) or U0126 (a selective inhibitor of extracellular signal regulated kinase 1/2, ERK1/2) or SP600125 (a selective inhibitor of c-jun N-termanal kinase, JNK) before exposure to HG, respectively.	naringin	87-95	mitogen-activated protein kinase 8	Rattus norvegicus	293-296
24118820-10	2014	In conclusion, our findings provide new evidence for the first time that naringin protects against HG-induced injuries by inhibiting the activation of MAPK (p38 MAPK, ERK1/2 and JNK) and oxidative stress in H9c2 cells.	naringin	73-81	mitogen activated protein kinase 14	Rattus norvegicus	157-160
24118820-10	2014	In conclusion, our findings provide new evidence for the first time that naringin protects against HG-induced injuries by inhibiting the activation of MAPK (p38 MAPK, ERK1/2 and JNK) and oxidative stress in H9c2 cells.	naringin	73-81	mitogen activated protein kinase 3	Rattus norvegicus	167-173
24118820-10	2014	In conclusion, our findings provide new evidence for the first time that naringin protects against HG-induced injuries by inhibiting the activation of MAPK (p38 MAPK, ERK1/2 and JNK) and oxidative stress in H9c2 cells.	naringin	73-81	mitogen-activated protein kinase 8	Rattus norvegicus	178-181
24683411-6	2014	There was a significant (P < 0.05) and dose dependant inhibition of macroscopical score, ulcer area along with colonic MDA, MPO activity by the 7 days of pretreatment of naringin (40 and 80 mg/kg).	naringin	173-181	myeloperoxidase	Rattus norvegicus	127-130
24683411-9	2014	The findings of the present investigation propose that naringin has an anti-inflammatory, anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA, MPO, NO and XO, thus reducing DNA damage.	naringin	55-63	myeloperoxidase	Rattus norvegicus	241-244
25391245-0	2014	Naringin inhibits TNF-alpha induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-kappa B and PI3K/Akt pathways.	naringin	0-8	tumor necrosis factor	Homo sapiens	18-27
25391245-0	2014	Naringin inhibits TNF-alpha induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-kappa B and PI3K/Akt pathways.	naringin	0-8	NADPH oxidase 4	Homo sapiens	93-97
25500624-10	2014	Furthermore, naringin completely restored cognitive function in MHE/DA (10 microg)-treated models by activating the JAK2/STAT3 axis, paralleling the upregulation of ChAT and sensitization of M1 mAChR.	naringin	13-21	Janus kinase 2	Rattus norvegicus	116-120
25500624-10	2014	Furthermore, naringin completely restored cognitive function in MHE/DA (10 microg)-treated models by activating the JAK2/STAT3 axis, paralleling the upregulation of ChAT and sensitization of M1 mAChR.	naringin	13-21	signal transducer and activator of transcription 3	Rattus norvegicus	121-126
25391245-0	2014	Naringin inhibits TNF-alpha induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-kappa B and PI3K/Akt pathways.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	118-121
25391245-3	2014	The aim of this trial was to determine the anti-oxidative and anti-inflammatory effects of naringin and uncover the mechanisms in Tumor Necrosis Factor-alpha (TNF-alpha) induced Human Umbilical Vein Endothelial Cells (HUVECs).	naringin	91-99	tumor necrosis factor	Homo sapiens	159-168
25391245-8	2014	Naringin inhibited TNF-alpha induced mRNA and protein over-expressions of ICAM-1 and VCAM-1.	naringin	0-8	tumor necrosis factor	Homo sapiens	19-28
23510099-7	2013	Chronic administration of naringin significantly improved cognitive performance and attenuated mitochondria oxidative damage, acetyl cholinesterase activity, and aluminum concentration in aluminum-treated rats as compared to control rats.	naringin	26-34	butyrylcholinesterase	Rattus norvegicus	133-147
25391245-8	2014	Naringin inhibited TNF-alpha induced mRNA and protein over-expressions of ICAM-1 and VCAM-1.	naringin	0-8	intercellular adhesion molecule 1	Homo sapiens	74-80
25391245-8	2014	Naringin inhibited TNF-alpha induced mRNA and protein over-expressions of ICAM-1 and VCAM-1.	naringin	0-8	vascular cell adhesion molecule 1	Homo sapiens	85-91
25391245-10	2014	These results indicated the preventive effects of naringin on HUVECs injury caused by oxidative stress and inflammation response and the effects might be obtained via inhibition of Nox4 and NF-kappaB pathways as well as activation of PI3K/Akt pathway.	naringin	50-58	NADPH oxidase 4	Homo sapiens	181-185
25391245-10	2014	These results indicated the preventive effects of naringin on HUVECs injury caused by oxidative stress and inflammation response and the effects might be obtained via inhibition of Nox4 and NF-kappaB pathways as well as activation of PI3K/Akt pathway.	naringin	50-58	AKT serine/threonine kinase 1	Homo sapiens	239-242
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	heat shock protein family B (small) member 1	Rattus norvegicus	208-213
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	215-220
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	catenin beta 1	Rattus norvegicus	222-234
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	AKT serine/threonine kinase 1	Rattus norvegicus	264-267
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	AKT serine/threonine kinase 1	Rattus norvegicus	268-271
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	Eph receptor B1	Rattus norvegicus	279-282
24324809-7	2013	This amelioration of post-IR-associated cardiac injury by naringin was accompanied by increased nitric oxide (NO) bioavailability, decreased NO inactivation to nitrotyrosine, amplified protein expressions of Hsp27, Hsp70, beta-catenin and increased p-eNOS/eNOS, p-Akt/Akt, and p-ERK/ERK ratio.	naringin	58-66	Eph receptor B1	Rattus norvegicus	283-286
24324809-11	2013	Thus, naringin restored IR injury by preserving myocardial structural integrity and regulating Hsp27, Hsp70, p-eNOS/p-Akt/p-ERK signaling and inflammatory response.	naringin	6-14	heat shock protein family B (small) member 1	Rattus norvegicus	95-100
24324809-11	2013	Thus, naringin restored IR injury by preserving myocardial structural integrity and regulating Hsp27, Hsp70, p-eNOS/p-Akt/p-ERK signaling and inflammatory response.	naringin	6-14	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	102-107
24324809-11	2013	Thus, naringin restored IR injury by preserving myocardial structural integrity and regulating Hsp27, Hsp70, p-eNOS/p-Akt/p-ERK signaling and inflammatory response.	naringin	6-14	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
24324809-11	2013	Thus, naringin restored IR injury by preserving myocardial structural integrity and regulating Hsp27, Hsp70, p-eNOS/p-Akt/p-ERK signaling and inflammatory response.	naringin	6-14	Eph receptor B1	Rattus norvegicus	124-127
23172577-1	2013	The aim of this study was to assess the effect of the flavonoid naringin on the growth of the spheno-occipital synchondrosis by quantifying the levels of expression of Sox9 and PTHrP in an in vitro mouse model.	naringin	64-72	SRY (sex determining region Y)-box 9	Mus musculus	168-172
23172577-1	2013	The aim of this study was to assess the effect of the flavonoid naringin on the growth of the spheno-occipital synchondrosis by quantifying the levels of expression of Sox9 and PTHrP in an in vitro mouse model.	naringin	64-72	parathyroid hormone-like peptide	Mus musculus	177-182
23172577-7	2013	In conclusion, naringin enhances the growth of the spheno-occipital synchondrosis through over expression of Sox9.	naringin	15-23	SRY (sex determining region Y)-box 9	Mus musculus	109-113
23794501-3	2013	Eight major flavonoids (naringin, naringenin, hesperidin, hesperetin, phloridzin, phloretin, quercetin, and kaempferol) contained in the juices inhibited OATP2B1-mediated estrone-3-sulfate uptake with IC50 values of 4.63, 49.2, 1.92, 67.6, 23.2, 1.31, 9.47, and 21.3 muM, respectively.	naringin	24-32	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	154-161
23794501-7	2013	In conclusion, our results indicate that naringin and hesperidin are the major OATP2B1 inhibitors in GFJ and OJ, respectively, whereas a combination of multiple components appears to be responsible for OATP2B1 inhibition by AJ.	naringin	41-49	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	79-86
25391245-0	2014	Naringin inhibits TNF-alpha induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-kappa B and PI3K/Akt pathways.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	98-108
23478434-5	2013	After 16 weeks of treatment, we observed that treatment with naringin (100 mg/kg body weight/day) enhanced the autophosphorylation of CaMKII, increased the phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptor at a CaMKII-dependent site and improved long-term learning and memory ability.	naringin	61-69	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	134-140
23603004-8	2013	Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-alpha, TGF-beta1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1.	naringin	20-28	tumor necrosis factor	Mus musculus	99-108
23603004-8	2013	Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-alpha, TGF-beta1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1.	naringin	20-28	transforming growth factor, beta 1	Mus musculus	110-119
23603004-8	2013	Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-alpha, TGF-beta1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1.	naringin	20-28	matrix metallopeptidase 9	Mus musculus	121-126
23603004-8	2013	Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-alpha, TGF-beta1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1.	naringin	20-28	tissue inhibitor of metalloproteinase 1	Mus musculus	131-137
23732220-4	2013	The effect of NAR on apoptosis was assessed by Annexin V and propidium iodide staining, and by determining the levels of active caspase-3, -8 and -9.	naringin	14-17	annexin A5	Rattus norvegicus	47-56
23694763-8	2013	Correspondingly, the antitumor potential of naringin was also observed in naringin-treated MDA-MB-231 xenograft mice, while immunohistochemical analysis of tumors from naringin-treated mice showed higher expression of p21 and lower expression of survivin and active beta-catenin.	naringin	44-52	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	218-221
23694763-8	2013	Correspondingly, the antitumor potential of naringin was also observed in naringin-treated MDA-MB-231 xenograft mice, while immunohistochemical analysis of tumors from naringin-treated mice showed higher expression of p21 and lower expression of survivin and active beta-catenin.	naringin	44-52	baculoviral IAP repeat-containing 5	Mus musculus	246-254
23694763-8	2013	Correspondingly, the antitumor potential of naringin was also observed in naringin-treated MDA-MB-231 xenograft mice, while immunohistochemical analysis of tumors from naringin-treated mice showed higher expression of p21 and lower expression of survivin and active beta-catenin.	naringin	44-52	catenin (cadherin associated protein), beta 1	Mus musculus	266-278
23694763-9	2013	Taken together, these results indicate that naringin could inhibit growth potential of TNBC cells by modulating beta-catenin pathway, which suggests naringin might be used as a potential supplement for the prevention and treatment of breast cancer.	naringin	44-52	catenin beta 1	Homo sapiens	112-124
23694763-9	2013	Taken together, these results indicate that naringin could inhibit growth potential of TNBC cells by modulating beta-catenin pathway, which suggests naringin might be used as a potential supplement for the prevention and treatment of breast cancer.	naringin	149-157	catenin beta 1	Homo sapiens	112-124
23567315-0	2013	In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.	naringin	109-117	cytochrome b5 type A	Homo sapiens	121-134
23462015-7	2013	The activities of antioxidant enzymes increased in the livers of the HFHC diet-fed MCP-3 mice, whereas supplementation with antioxidants, naringin and hesperidin, reversed the activities of the hepatic antioxidant enzymes in HFHC diet-fed MCP-3 mice, indicating that there might be more oxidative damage to the tissues in the HFHC diet-fed MCP-3 mice leading to progression towards atherosclerosis and hepatic steatosis.	naringin	138-146	chemokine (C-C motif) ligand 7	Mus musculus	239-244
23462015-7	2013	The activities of antioxidant enzymes increased in the livers of the HFHC diet-fed MCP-3 mice, whereas supplementation with antioxidants, naringin and hesperidin, reversed the activities of the hepatic antioxidant enzymes in HFHC diet-fed MCP-3 mice, indicating that there might be more oxidative damage to the tissues in the HFHC diet-fed MCP-3 mice leading to progression towards atherosclerosis and hepatic steatosis.	naringin	138-146	chemokine (C-C motif) ligand 7	Mus musculus	239-244
23478434-5	2013	After 16 weeks of treatment, we observed that treatment with naringin (100 mg/kg body weight/day) enhanced the autophosphorylation of CaMKII, increased the phosphorylation of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic (AMPA) receptor at a CaMKII-dependent site and improved long-term learning and memory ability.	naringin	61-69	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	252-258
22847135-8	2013	In addition, administration of naringin increased the expression of caspases, p53 and Bax, Fas death receptor and its adaptor protein FADD.	naringin	31-39	tumor protein p53	Homo sapiens	78-81
23717961-4	2013	Both compound 1 and its derivatives--naringin could improve glucose consumption in IR HepG2 cells and enhance GLUT4 translocation in skeletal muscle cell L6myc in a dose-dependent manner, indicating that these two compouds showed potential anti-diabetic activities in vitro.	naringin	37-45	solute carrier family 2 member 4	Homo sapiens	110-115
22847135-8	2013	In addition, administration of naringin increased the expression of caspases, p53 and Bax, Fas death receptor and its adaptor protein FADD.	naringin	31-39	BCL2 associated X, apoptosis regulator	Homo sapiens	86-89
22847135-8	2013	In addition, administration of naringin increased the expression of caspases, p53 and Bax, Fas death receptor and its adaptor protein FADD.	naringin	31-39	Fas associated via death domain	Homo sapiens	134-138
22766066-1	2012	Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-kappaB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways.	naringin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	136-145
23132664-3	2013	Eight major flavonoids (naringin, naringenin, hesperidin, hesperetin, phloridzin, phloretin, quercetin, and kaempferol) contained in the juices inhibited OATP2B1-mediated estrone-3-sulfate uptake with IC(50) values of 4.63, 49.2, 1.92, 67.6, 23.2, 1.31, 9.47, and 21.3 microM, respectively.	naringin	24-32	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	154-161
23132664-7	2013	In conclusion, our results indicate that naringin and hesperidin are the major OATP2B1 inhibitors in GFJ and OJ, respectively, whereas a combination of multiple components appears to be responsible for OATP2B1 inhibition by AJ.	naringin	41-49	solute carrier organic anion transporter family member 2B1 L homeolog	Xenopus laevis	79-86
24080610-2	2013	Recently, it was reported that naringin, a flavonoid constituent of the PF extract, causes the activation of ghrelin receptor in vitro.	naringin	31-39	growth hormone secretagogue receptor	Rattus norvegicus	109-125
24080610-7	2013	Surprisingly, pharmacokinetic analysis revealed that naringin has low bioavailability (11%), implying that the prokinetic effect of naringin was largely due to the local activation of ghrelin receptor in the intestine rather than a systemic effect after absorption.	naringin	53-61	growth hormone secretagogue receptor	Rattus norvegicus	184-200
24080610-7	2013	Surprisingly, pharmacokinetic analysis revealed that naringin has low bioavailability (11%), implying that the prokinetic effect of naringin was largely due to the local activation of ghrelin receptor in the intestine rather than a systemic effect after absorption.	naringin	132-140	growth hormone secretagogue receptor	Rattus norvegicus	184-200
22965302-8	2012	Naringin also attenuated MAPK activation by inhibiting the phosphorylation             of ERK1/2, JNK and p38 MAPK.	naringin	0-8	mitogen-activated protein kinase 1	Mus musculus	25-29
22965302-8	2012	Naringin also attenuated MAPK activation by inhibiting the phosphorylation             of ERK1/2, JNK and p38 MAPK.	naringin	0-8	mitogen-activated protein kinase 3	Mus musculus	90-96
22965302-8	2012	Naringin also attenuated MAPK activation by inhibiting the phosphorylation             of ERK1/2, JNK and p38 MAPK.	naringin	0-8	mitogen-activated protein kinase 8	Mus musculus	98-101
22965302-8	2012	Naringin also attenuated MAPK activation by inhibiting the phosphorylation             of ERK1/2, JNK and p38 MAPK.	naringin	0-8	mitogen-activated protein kinase 14	Mus musculus	106-114
22965302-9	2012	Taken together, these demonstrate that naringin reduces             IL-8, MCP-1 and MIP-1alpha secretion and mRNA expression, possibly by blocking the             activation of the NF-kappaB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.	naringin	39-47	chemokine (C-X-C motif) ligand 15	Mus musculus	68-72
22965302-9	2012	Taken together, these demonstrate that naringin reduces             IL-8, MCP-1 and MIP-1alpha secretion and mRNA expression, possibly by blocking the             activation of the NF-kappaB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.	naringin	39-47	chemokine (C-C motif) ligand 2	Mus musculus	74-79
22965302-9	2012	Taken together, these demonstrate that naringin reduces             IL-8, MCP-1 and MIP-1alpha secretion and mRNA expression, possibly by blocking the             activation of the NF-kappaB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.	naringin	39-47	mitogen-activated protein kinase 1	Mus musculus	195-199
22985397-5	2012	Moreover, naringin of 20, 40, and 80 mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-alpha and interleukin-8 (IL-8).	naringin	10-18	myeloperoxidase	Rattus norvegicus	110-125
22985397-5	2012	Moreover, naringin of 20, 40, and 80 mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-alpha and interleukin-8 (IL-8).	naringin	10-18	matrix metallopeptidase 9	Rattus norvegicus	130-156
22985397-5	2012	Moreover, naringin of 20, 40, and 80 mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-alpha and interleukin-8 (IL-8).	naringin	10-18	tumor necrosis factor	Rattus norvegicus	224-251
22821418-10	2012	7-Nitroindazole [a neuronal nitric oxide synthase (NOS) inhibitor] and aminoguanidine (an inducible NOS inhibitor) significantly enhanced memory improving activity and brain nitrite decreasing effect of naringin in unstressed and stressed mice respectively.	naringin	203-211	nitric oxide synthase 1, neuronal	Mus musculus	19-49
22821418-12	2012	Thus, naringin showed memory enhancing activity in unstressed mice probably by decreasing brain AChE activity and by inhibition of neuronal NOS.	naringin	6-14	acetylcholinesterase	Mus musculus	96-100
22766066-1	2012	Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-kappaB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways.	naringin	28-36	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	69-75
22766066-1	2012	Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-kappaB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways.	naringin	28-36	nuclear factor kappa B subunit 1	Homo sapiens	112-134
22871521-0	2012	Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-173
22871521-9	2012	Naringin induces NAD(P)H:quinone oxidoreductase-1, heme oxygenase-1, glutathione S-transferase P1 and gamma-glutamylcysteine ligase mRNA expressions through the activation of Nrf2 and decreased the expressions of pro-inflammatory mediators like tumour necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase.	naringin	0-8	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	17-49
22871521-9	2012	Naringin induces NAD(P)H:quinone oxidoreductase-1, heme oxygenase-1, glutathione S-transferase P1 and gamma-glutamylcysteine ligase mRNA expressions through the activation of Nrf2 and decreased the expressions of pro-inflammatory mediators like tumour necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase.	naringin	0-8	heme oxygenase 1	Rattus norvegicus	51-67
22871521-9	2012	Naringin induces NAD(P)H:quinone oxidoreductase-1, heme oxygenase-1, glutathione S-transferase P1 and gamma-glutamylcysteine ligase mRNA expressions through the activation of Nrf2 and decreased the expressions of pro-inflammatory mediators like tumour necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179
22871521-9	2012	Naringin induces NAD(P)H:quinone oxidoreductase-1, heme oxygenase-1, glutathione S-transferase P1 and gamma-glutamylcysteine ligase mRNA expressions through the activation of Nrf2 and decreased the expressions of pro-inflammatory mediators like tumour necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase.	naringin	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	275-291
22871521-9	2012	Naringin induces NAD(P)H:quinone oxidoreductase-1, heme oxygenase-1, glutathione S-transferase P1 and gamma-glutamylcysteine ligase mRNA expressions through the activation of Nrf2 and decreased the expressions of pro-inflammatory mediators like tumour necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase.	naringin	0-8	nitric oxide synthase 2	Rattus norvegicus	296-327
22871521-10	2012	These results indicate that naringin might be beneficial in mitigating 3-NP-induced neurodegeneration through the enhancement of phase II and antioxidant gene expressions via Nrf2 activation; thereby modulating the oxidative stress and inflammatory responses.	naringin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179
22766066-1	2012	Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-kappaB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways.	naringin	28-36	AKT serine/threonine kinase 1	Homo sapiens	161-164
22766066-1	2012	Naringenin, the aglycone of naringin, has been reported to attenuate MUC5AC secretion by inhibiting activity of nuclear factor kappa B (NF-kappaB) via EGFR-PI3K-Akt/ERK MAPKinase signaling pathways.	naringin	28-36	mitogen-activated protein kinase 1	Homo sapiens	165-168
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	epidermal growth factor	Homo sapiens	77-80
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	113-119
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	epidermal growth factor	Homo sapiens	193-196
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	mitogen-activated protein kinase 1	Homo sapiens	207-210
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	mitogen-activated protein kinase 3	Homo sapiens	245-249
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	mitogen-activated protein kinase 3	Homo sapiens	291-297
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	mitogen-activated protein kinase 8	Homo sapiens	304-327
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	mitogen-activated protein kinase 8	Homo sapiens	329-332
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	nuclear factor kappa B subunit 1	Homo sapiens	354-363
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	RELA proto-oncogene, NF-kB subunit	Homo sapiens	364-367
22766066-4	2012	The results showed that naringin of 100 muM not only significantly decreased EGF-induced overexpressions of both MUC5AC mucin and mRNA in A549 cells, but also suppressed the phosphorylation of EGF receptor, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and c-Jun N-terminal kinase (JNK), as well as nucleus NF-kappaB p65 and AP-1.	naringin	24-32	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	372-376
22453521-0	2012	Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury.	naringin	0-8	brain-derived neurotrophic factor	Rattus norvegicus	62-66
22453521-0	2012	Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury.	naringin	0-8	vascular endothelial growth factor A	Rattus norvegicus	71-75
22453521-10	2012	In addition, naringin treatment significantly increased in Bcl-2:Bax ratio, reduced the enzyme activity of caspase-3 and decreased the number of apoptotic cells after SCI.	naringin	13-21	BCL2, apoptosis regulator	Rattus norvegicus	59-64
22453521-10	2012	In addition, naringin treatment significantly increased in Bcl-2:Bax ratio, reduced the enzyme activity of caspase-3 and decreased the number of apoptotic cells after SCI.	naringin	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	65-68
22453521-10	2012	In addition, naringin treatment significantly increased in Bcl-2:Bax ratio, reduced the enzyme activity of caspase-3 and decreased the number of apoptotic cells after SCI.	naringin	13-21	caspase 3	Rattus norvegicus	107-116
22453521-11	2012	These findings suggest that naringin treatment starting 1 day after SCI can significantly improve locomotor recovery, and this neuroprotective effect may be related to the upregulation of BDNF and VEGF and the inhibition of neural apoptosis.	naringin	28-36	brain-derived neurotrophic factor	Rattus norvegicus	188-192
22453521-11	2012	These findings suggest that naringin treatment starting 1 day after SCI can significantly improve locomotor recovery, and this neuroprotective effect may be related to the upregulation of BDNF and VEGF and the inhibition of neural apoptosis.	naringin	28-36	vascular endothelial growth factor A	Rattus norvegicus	197-201
21964193-9	2011	Naringin and naringenin exhibited higher binding capacity to estrogen receptor beta (ERbeta) than estrogen receptor alpha (ERalpha) in yeast two-hybrid experiments and nuclear receptor cofactor assays (RCAS) experiment.	naringin	0-8	estrogen receptor 2	Homo sapiens	61-83
22420660-9	2012	The greatest results were obtained for solid dispersions in the presence of P-gp inhibitors at their highest concentrations, with an absorption improvement of 3.41- and 3.91-fold for naringin (15mg/kg) and quinidine (200microm), respectively.	naringin	183-191	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	76-80
22854627-8	2012	Naringin, however, significantly blunted the effect of glucose depletion and oxidative stress on Fluo-3 fluorescence, erythrocyte forward scatter or annexin-V-binding.	naringin	0-8	annexin A5	Homo sapiens	149-158
22005257-3	2011	Naringin also inhibited platelet aggregation induced by collagen, AA, or thrombin, but not aggregation induced by ADP.	naringin	0-8	coagulation factor II	Rattus norvegicus	73-81
22410395-3	2012	Therefore, in the present work we tried to explore a naturally occurring compound naringin for its potential DPP-IV inhibition and antidiabetic potential.	naringin	82-90	dipeptidylpeptidase 4	Rattus norvegicus	109-115
22741174-1	2012	Naringin, a bioflavonoid, has been reported to have potent neuro-protective effects, but its preventive effects on amyloid-beta (Abeta) induced, Alzheimer"s disease (AD) related, cognitive impairment, and the underlying mechanisms of these effects have not been well characterised.	naringin	0-8	amyloid beta (A4) precursor protein	Mus musculus	129-134
22741174-4	2012	Furthermore, GSK-3beta phosphorylation significantly increased in the naringin-treated (100 mg/kg/day) group.	naringin	70-78	glycogen synthase kinase 3 alpha	Mus musculus	13-22
22741174-5	2012	These findings suggest that a reduction in plaque burden and an increase in glucose uptake through the inhibition of GSK-3beta activity may be one of the mechanisms by which naringin improves cognitive functioning in the APPswe/ PSDeltaE9 transgenic mouse model of Alzheimer"s disease.	naringin	174-182	glycogen synthase kinase 3 alpha	Mus musculus	117-126
22213297-0	2012	Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor alpha levels in rats with Walker 256 carcinosarcoma.	naringin	0-8	interleukin 6	Rattus norvegicus	43-56
22213297-0	2012	Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor alpha levels in rats with Walker 256 carcinosarcoma.	naringin	0-8	tumor necrosis factor	Rattus norvegicus	61-88
22213297-9	2012	Inhibition of tumor growth, survival increase and the reduction of TNF-alpha and IL-6 levels in rats bearing W256 treated with naringin strongly suggest that this compound has potential as an anticarcinogenic drug.	naringin	127-135	tumor necrosis factor	Rattus norvegicus	67-76
22213297-9	2012	Inhibition of tumor growth, survival increase and the reduction of TNF-alpha and IL-6 levels in rats bearing W256 treated with naringin strongly suggest that this compound has potential as an anticarcinogenic drug.	naringin	127-135	interleukin 6	Rattus norvegicus	81-85
22074828-3	2011	We aimed to investigate the different effects of three representative flavonoids-hesperidin, naringin, and resveratrol-on intracellular adhesion molecule-1 (ICAM-1) induction in human umbilical vein endothelial cells (HUVECs) by using high-glucose (HG) concentrations and the possible underlying molecular mechanisms.	naringin	93-101	intercellular adhesion molecule 1	Homo sapiens	157-163
22074828-10	2011	This study demonstrated that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells.	naringin	41-49	intercellular adhesion molecule 1	Homo sapiens	90-96
22074828-10	2011	This study demonstrated that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells.	naringin	41-49	mitogen-activated protein kinase 1	Homo sapiens	116-119
22074828-10	2011	This study demonstrated that hesperidin, naringin, and resveratrol reduced the HG-induced ICAM-1 expression via the p38 MAPK signaling pathway, contributing to the inhibition of monocyte adhesion to endothelial cells.	naringin	41-49	mitogen-activated protein kinase 1	Homo sapiens	120-124
21736771-7	2011	Moreover, naringin robustly increased PPARgamma expression in liver and kidney; phosphorylated tyrosine insulin receptor substrate 1 in liver; and stress proteins heat shock protein (HSP)-27 and HSP-72 in pancreas, liver and kidney.	naringin	10-18	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	38-47
21736771-7	2011	Moreover, naringin robustly increased PPARgamma expression in liver and kidney; phosphorylated tyrosine insulin receptor substrate 1 in liver; and stress proteins heat shock protein (HSP)-27 and HSP-72 in pancreas, liver and kidney.	naringin	10-18	insulin receptor substrate 1	Rattus norvegicus	104-132
21736771-7	2011	Moreover, naringin robustly increased PPARgamma expression in liver and kidney; phosphorylated tyrosine insulin receptor substrate 1 in liver; and stress proteins heat shock protein (HSP)-27 and HSP-72 in pancreas, liver and kidney.	naringin	10-18	heat shock protein family B (small) member 1	Rattus norvegicus	163-190
21736771-7	2011	Moreover, naringin robustly increased PPARgamma expression in liver and kidney; phosphorylated tyrosine insulin receptor substrate 1 in liver; and stress proteins heat shock protein (HSP)-27 and HSP-72 in pancreas, liver and kidney.	naringin	10-18	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	195-201
21736771-10	2011	Thus, this seminal study provides cogent evidence that naringin ameliorates IR, dyslipidaemia, beta-cell dysfunction, hepatic steatosis and kidney damage in type 2 diabetic rats by partly regulating oxidative stress, inflammation and dysregulated adipocytokines production through up-regulation of PPARgamma, HSP-27 and HSP-72.	naringin	55-63	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	298-307
21736771-10	2011	Thus, this seminal study provides cogent evidence that naringin ameliorates IR, dyslipidaemia, beta-cell dysfunction, hepatic steatosis and kidney damage in type 2 diabetic rats by partly regulating oxidative stress, inflammation and dysregulated adipocytokines production through up-regulation of PPARgamma, HSP-27 and HSP-72.	naringin	55-63	heat shock protein family B (small) member 1	Rattus norvegicus	309-315
21736771-10	2011	Thus, this seminal study provides cogent evidence that naringin ameliorates IR, dyslipidaemia, beta-cell dysfunction, hepatic steatosis and kidney damage in type 2 diabetic rats by partly regulating oxidative stress, inflammation and dysregulated adipocytokines production through up-regulation of PPARgamma, HSP-27 and HSP-72.	naringin	55-63	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	320-326
21945202-12	2011	Further, naringin antagonized 3-NP-induced decrease in Bcl-2 mRNA expression.	naringin	9-17	BCL2, apoptosis regulator	Rattus norvegicus	55-60
21964193-9	2011	Naringin and naringenin exhibited higher binding capacity to estrogen receptor beta (ERbeta) than estrogen receptor alpha (ERalpha) in yeast two-hybrid experiments and nuclear receptor cofactor assays (RCAS) experiment.	naringin	0-8	estrogen receptor 2	Homo sapiens	85-91
21640201-7	2011	Furthermore, naringin inhibited myeloperoxidase (MPO: a marker enzyme of neutrophil granule) and inducible nitric oxide synthase (iNOS) activities in lung tissue and alleviated LPS-induced tumor neurosis factor-alpha (TNF-alpha) secretion in BALF in a dose-dependent manner.	naringin	13-21	myeloperoxidase	Mus musculus	49-52
21640201-7	2011	Furthermore, naringin inhibited myeloperoxidase (MPO: a marker enzyme of neutrophil granule) and inducible nitric oxide synthase (iNOS) activities in lung tissue and alleviated LPS-induced tumor neurosis factor-alpha (TNF-alpha) secretion in BALF in a dose-dependent manner.	naringin	13-21	nitric oxide synthase 2, inducible	Mus musculus	97-128
21640201-7	2011	Furthermore, naringin inhibited myeloperoxidase (MPO: a marker enzyme of neutrophil granule) and inducible nitric oxide synthase (iNOS) activities in lung tissue and alleviated LPS-induced tumor neurosis factor-alpha (TNF-alpha) secretion in BALF in a dose-dependent manner.	naringin	13-21	nitric oxide synthase 2, inducible	Mus musculus	130-134
21640201-7	2011	Furthermore, naringin inhibited myeloperoxidase (MPO: a marker enzyme of neutrophil granule) and inducible nitric oxide synthase (iNOS) activities in lung tissue and alleviated LPS-induced tumor neurosis factor-alpha (TNF-alpha) secretion in BALF in a dose-dependent manner.	naringin	13-21	tumor necrosis factor	Mus musculus	218-227
21640201-9	2011	Taken together, these results suggest that naringin shows anti-inflammatory effects through inhibiting lung edema, MPO and iNOS activities, TNF-alpha secretion and pulmonary neutrophil infiltration by blockade of NF-kappaB in LPS-induced ALI.	naringin	43-51	myeloperoxidase	Mus musculus	115-118
21640201-9	2011	Taken together, these results suggest that naringin shows anti-inflammatory effects through inhibiting lung edema, MPO and iNOS activities, TNF-alpha secretion and pulmonary neutrophil infiltration by blockade of NF-kappaB in LPS-induced ALI.	naringin	43-51	nitric oxide synthase 2, inducible	Mus musculus	123-127
21640201-9	2011	Taken together, these results suggest that naringin shows anti-inflammatory effects through inhibiting lung edema, MPO and iNOS activities, TNF-alpha secretion and pulmonary neutrophil infiltration by blockade of NF-kappaB in LPS-induced ALI.	naringin	43-51	tumor necrosis factor	Mus musculus	140-149
21640201-9	2011	Taken together, these results suggest that naringin shows anti-inflammatory effects through inhibiting lung edema, MPO and iNOS activities, TNF-alpha secretion and pulmonary neutrophil infiltration by blockade of NF-kappaB in LPS-induced ALI.	naringin	43-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	213-222
21633340-3	2011	Naringin, an OATP1A2 inhibitor, decreased the transport of imatinib in OATP1A2-transfected HEK293 cells, the human intestinal cell line Caco-2, and K562 CML cells.	naringin	0-8	solute carrier organic anion transporter family member 1A2	Homo sapiens	13-20
21835177-0	2011	Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kappaB and ERK activation.	naringin	0-8	TNF superfamily member 11	Rattus norvegicus	80-85
21835177-0	2011	Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kappaB and ERK activation.	naringin	0-8	Eph receptor B1	Rattus norvegicus	108-111
21835177-6	2011	In addition, naringin inhibited RANKL-induced phosphorylation of ERK.	naringin	13-21	TNF superfamily member 11	Rattus norvegicus	32-37
21835177-6	2011	In addition, naringin inhibited RANKL-induced phosphorylation of ERK.	naringin	13-21	Eph receptor B1	Rattus norvegicus	65-68
21500970-13	2011	However, RANTES expression detected in supernatant stimulated with TNF-alpha/IFN-gamma reduced 15 and 16%, respectively, when cultured with 0.25, 0.5 mmol/L naringin.	naringin	157-165	C-C motif chemokine ligand 5	Homo sapiens	9-15
21500970-13	2011	However, RANTES expression detected in supernatant stimulated with TNF-alpha/IFN-gamma reduced 15 and 16%, respectively, when cultured with 0.25, 0.5 mmol/L naringin.	naringin	157-165	tumor necrosis factor	Homo sapiens	67-76
21500970-13	2011	However, RANTES expression detected in supernatant stimulated with TNF-alpha/IFN-gamma reduced 15 and 16%, respectively, when cultured with 0.25, 0.5 mmol/L naringin.	naringin	157-165	interferon gamma	Homo sapiens	77-86
24250392-6	2011	In the treatment groups, both Rutin and Naringin in combination with insulin treatment in diabetic rats produced protection from diabetes and improved all the sperm parameters, decreased the MDA levels and increased the SOD and catalase levels.	naringin	40-48	catalase	Rattus norvegicus	228-236
21633340-3	2011	Naringin, an OATP1A2 inhibitor, decreased the transport of imatinib in OATP1A2-transfected HEK293 cells, the human intestinal cell line Caco-2, and K562 CML cells.	naringin	0-8	solute carrier organic anion transporter family member 1A2	Homo sapiens	71-78
20691757-4	2010	The results showed that naringin and nobiletin inhibited the decrease of cell viability (MTT reduction), prevented membrane damage (LDH release), scavenged ROS formation, reduced caspase-3 activity, and attenuated the decrease of mitochondrial membrane potential (MMP), respectively, in H(2)O(2)-induced PC12 cells.	naringin	24-32	caspase 3	Rattus norvegicus	179-188
21372385-8	2011	In addition, naringin dose-dependently attenuated the KA-induced increase in the TNF-alpha levels of brain.	naringin	13-21	tumor necrosis factor	Rattus norvegicus	81-90
21206133-3	2011	Naringin inhibited Oatp1a5- and Mdr1a-mediated transport of pitavastatin with IC(50) values of 18.5 and 541 microM, respectively.	naringin	0-8	ATP binding cassette subfamily B member 1A	Rattus norvegicus	32-37
20660284-1	2010	The citrus flavonoids hesperidin and naringin have been suggested to lower blood total (TC) and LDL-cholesterol (LDL-C) both in animal models and humans.	naringin	37-45	component of oligomeric golgi complex 2	Homo sapiens	96-111
20686826-6	2010	Naringin, a potent inhibitor of Oatps and Mdr1, decreased the Oatp1a5-mediated uptake of pravastatin with IC (50) value of 30.4 muM.	naringin	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	42-46
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	naringin	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75
21535545-6	2010	Otherwise, all tested flavonoids possessed the inhibitory activity to COX-2 reaction, and especially luteolin, kaempferol, hesperetin, and naringin showed relatively the potent inhibition on COX-2 reaction.	naringin	139-147	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	191-196
20660284-1	2010	The citrus flavonoids hesperidin and naringin have been suggested to lower blood total (TC) and LDL-cholesterol (LDL-C) both in animal models and humans.	naringin	37-45	component of oligomeric golgi complex 2	Homo sapiens	113-118
20673063-8	2010	Chronic treatment with naringin caused significant improvement in the cognitive performance and attenuated oxidative damage, as evidenced by lowering of malondialdehyde level and nitrite concentration and restoration of superoxide dismutase, catalase, glutathione S-transferase, and reduced glutathione levels, and acetylcholinesterase activity compared to control.	naringin	23-31	catalase	Rattus norvegicus	242-250
20673063-8	2010	Chronic treatment with naringin caused significant improvement in the cognitive performance and attenuated oxidative damage, as evidenced by lowering of malondialdehyde level and nitrite concentration and restoration of superoxide dismutase, catalase, glutathione S-transferase, and reduced glutathione levels, and acetylcholinesterase activity compared to control.	naringin	23-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	252-277
20673063-8	2010	Chronic treatment with naringin caused significant improvement in the cognitive performance and attenuated oxidative damage, as evidenced by lowering of malondialdehyde level and nitrite concentration and restoration of superoxide dismutase, catalase, glutathione S-transferase, and reduced glutathione levels, and acetylcholinesterase activity compared to control.	naringin	23-31	acetylcholinesterase	Rattus norvegicus	315-335
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	solute carrier organic anion transporter family member 1A2	Homo sapiens	72-110
20159712-8	2010	Naringin also suppressed high glucose-induced increment of NF-kappaB expression in the cell nuclei of HUVECs.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	59-68
20159712-9	2010	CONCLUSION: Naringin can suppress high glucose-induced vascular inflammation possibly by inhibiting ROS production and NF-kappaB activation in HUVECs.	naringin	12-20	nuclear factor kappa B subunit 1	Homo sapiens	119-128
19810018-3	2009	Naringin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of MMP-9, under 10-25 microM concentration conditions in vascular smooth muscle cells (VSMC).	naringin	0-8	tumor necrosis factor	Homo sapiens	19-46
19810018-3	2009	Naringin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of MMP-9, under 10-25 microM concentration conditions in vascular smooth muscle cells (VSMC).	naringin	0-8	tumor necrosis factor	Homo sapiens	48-57
19810018-3	2009	Naringin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced expression of MMP-9, under 10-25 microM concentration conditions in vascular smooth muscle cells (VSMC).	naringin	0-8	matrix metallopeptidase 9	Homo sapiens	81-86
19810018-5	2009	Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8).	naringin	13-21	tumor necrosis factor	Homo sapiens	33-42
19810018-5	2009	Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8).	naringin	13-21	interleukin 6	Homo sapiens	63-83
19810018-5	2009	Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8).	naringin	13-21	interleukin 6	Homo sapiens	85-89
19810018-5	2009	Furthermore, naringin suppressed TNF-alpha-mediated release of interleukin-6 and -8 (IL-6 and IL-8).	naringin	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	94-98
19810018-6	2009	However, naringin (10-25 microM) treatment of VSMC in the presence of TNF-alpha did not affect cell growth and apoptosis.	naringin	9-17	tumor necrosis factor	Homo sapiens	70-79
20684240-3	2010	Glycosylated flavonoids: rutin, naringin, baikalin and methylhesperidin were shown to inhibit furin at pH 7.2 reversibly and competitively with Ki- 80-200 microM.	naringin	32-40	furin, paired basic amino acid cleaving enzyme	Homo sapiens	94-99
19779132-6	2010	The present study indicated that the species difference in the effect of GFJ on intestinal absorption of talinolol between humans and rats may be due to differences in the affinity of naringin for OATP/Oatp and MDR1/Mdr1 transporters between the two species.	naringin	184-192	solute carrier organic anion transporter family member 1A2	Homo sapiens	197-201
19779132-6	2010	The present study indicated that the species difference in the effect of GFJ on intestinal absorption of talinolol between humans and rats may be due to differences in the affinity of naringin for OATP/Oatp and MDR1/Mdr1 transporters between the two species.	naringin	184-192	solute carrier organic anion transporter family member 1A2	Homo sapiens	202-206
19779132-6	2010	The present study indicated that the species difference in the effect of GFJ on intestinal absorption of talinolol between humans and rats may be due to differences in the affinity of naringin for OATP/Oatp and MDR1/Mdr1 transporters between the two species.	naringin	184-192	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	211-215
19779132-6	2010	The present study indicated that the species difference in the effect of GFJ on intestinal absorption of talinolol between humans and rats may be due to differences in the affinity of naringin for OATP/Oatp and MDR1/Mdr1 transporters between the two species.	naringin	184-192	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	216-220
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	solute carrier organic anion transporter family member 1A2	Homo sapiens	112-116
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	phosphoglycolate phosphatase	Homo sapiens	123-127
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	solute carrier organic anion transporter family member 1A2	Homo sapiens	326-330
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	solute carrier organic anion transporter family member 1A2	Homo sapiens	331-335
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	phosphoglycolate phosphatase	Homo sapiens	340-344
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	ATP binding cassette subfamily B member 1	Homo sapiens	369-373
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	190-198	ATP binding cassette subfamily B member 1	Homo sapiens	374-378
19779132-2	2010	Because our recent study indicated that the inhibitory effect of GFJ on organic anion-transporting polypeptide (Oatp)- and P-gp-mediated talinolol absorption depends on the concentration of naringin in ingested GFJ, the apparent inconsistent findings may be explained by the species difference in the affinity of naringin for OATP/Oatp and P-gp multidrug resistance 1 (MDR1/Mdr1) between humans and rats.	naringin	313-321	solute carrier organic anion transporter family member 1A2	Homo sapiens	112-116
19779132-4	2010	Because the naringin concentration in commercially prepared GFJ was found to be approximately 1200 microM, these results suggested that GFJ would reduce the intestinal absorption of talinolol through inhibition of OATP1A2-mediated talinolol uptake in humans, whereas an increase of talinolol absorption is mainly through inhibition of Mdr1a-mediated efflux in rats.	naringin	12-20	solute carrier organic anion transporter family member 1A2	Homo sapiens	214-221
19577560-7	2009	Naringin (50 mg/kg and 100 mg/kg) treatment significantly attenuated oxidative damage as indicated by reduced lipid peroxidation, nitrite concentration, restored reduced glutathione and catalase activity and mitochondrial enzyme activities in cortex, striatum, cerebellum as compared to control (ischemia reperfusion) animals.	naringin	0-8	catalase	Rattus norvegicus	186-194
18951945-4	2008	In addition, among the pathways examined, blockade of ERK function inhibited naringin-dependent p21WAF1 expression, reversed naringin-mediated inhibition of cell proliferation and decreased cell cycle proteins.	naringin	77-85	mitogen-activated protein kinase 1	Homo sapiens	54-57
19885011-4	2009	Naringin also blocked rotenone-induced phosphorylation of Jun NH2-terminal protein kinase (JNK) and P38, and prevented changes in B-cell CLL/lymphoma 2 (BCL2) and BCL2-associated X protein (BAX) expression levels.	naringin	0-8	mitogen-activated protein kinase 14	Homo sapiens	100-103
19885011-4	2009	Naringin also blocked rotenone-induced phosphorylation of Jun NH2-terminal protein kinase (JNK) and P38, and prevented changes in B-cell CLL/lymphoma 2 (BCL2) and BCL2-associated X protein (BAX) expression levels.	naringin	0-8	BCL2 apoptosis regulator	Homo sapiens	130-151
19885011-4	2009	Naringin also blocked rotenone-induced phosphorylation of Jun NH2-terminal protein kinase (JNK) and P38, and prevented changes in B-cell CLL/lymphoma 2 (BCL2) and BCL2-associated X protein (BAX) expression levels.	naringin	0-8	BCL2 apoptosis regulator	Homo sapiens	153-157
19885011-4	2009	Naringin also blocked rotenone-induced phosphorylation of Jun NH2-terminal protein kinase (JNK) and P38, and prevented changes in B-cell CLL/lymphoma 2 (BCL2) and BCL2-associated X protein (BAX) expression levels.	naringin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	163-188
19885011-4	2009	Naringin also blocked rotenone-induced phosphorylation of Jun NH2-terminal protein kinase (JNK) and P38, and prevented changes in B-cell CLL/lymphoma 2 (BCL2) and BCL2-associated X protein (BAX) expression levels.	naringin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	190-193
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	caspase 3	Homo sapiens	53-62
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	caspase 9	Homo sapiens	80-89
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	91-119
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	121-125
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	caspase 3	Homo sapiens	132-141
19323275-3	2009	In the present study, naringin (the predominant flavonone found in grapefruit and other related citrus species) was tested for its potential ability to modulate the expression of P-gp in a short-term animal bioassay, in comparison with verapamil (a calcium channel blocker and positive MDR reversal agent).	naringin	22-30	ATP binding cassette subfamily B member 1	Homo sapiens	179-183
19002566-9	2009	The reported IC (50) value of naringin for P-gp-mediated transport of talinolol is approximately 2,000 microM.	naringin	30-38	phosphoglycolate phosphatase	Rattus norvegicus	43-47
18951945-2	2008	However, the exact molecular mechanisms underlying the roles of integrated cell cycle regulation and MAPK signaling pathways in the regulation of naringin-induced inhibition of cell proliferation in vascular smooth muscle cells (VSMCs) remain to be identified.	naringin	146-154	mitogen-activated protein kinase 1	Homo sapiens	101-105
18951945-6	2008	Transfection of cells with dominant negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression.	naringin	101-109	zinc fingers and homeoboxes 2	Homo sapiens	62-65
18951945-6	2008	Transfection of cells with dominant negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression.	naringin	101-109	zinc fingers and homeoboxes 2	Homo sapiens	67-75
18951945-6	2008	Transfection of cells with dominant negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression.	naringin	101-109	mitogen-activated protein kinase 1	Homo sapiens	118-121
18296682-4	2008	In addition, naringin treatment strongly induced p21WAF1 expression, independent of the p53 pathway, and downregulated expression of cyclins and cyclin dependent kinases (CDKs).	naringin	13-21	tumor protein p53	Homo sapiens	88-91
18951945-7	2008	Finally, naringin-induced reduction in cell proliferation and cell cycle protein was abolished in the presence of RasN17 and RafS621A mutant genes.	naringin	9-17	zinc fingers and homeoboxes 2	Homo sapiens	125-133
18495116-0	2008	Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts.	naringin	0-8	bone morphogenetic protein 2	Homo sapiens	17-45
18495116-0	2008	Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	67-70
18495116-0	2008	Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts.	naringin	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	72-77
18495116-0	2008	Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts.	naringin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	78-83
18495116-0	2008	Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts.	naringin	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-92
18495116-4	2008	In this study, naringin a polymethoxylated flavonoid, was shown to enhance alkaline phosphatase activity, osteocalcin level, osteopontin synthesis and cell proliferation in primary cultured osteoblasts.	naringin	15-23	bone gamma-carboxyglutamate protein	Homo sapiens	106-117
18495116-4	2008	In this study, naringin a polymethoxylated flavonoid, was shown to enhance alkaline phosphatase activity, osteocalcin level, osteopontin synthesis and cell proliferation in primary cultured osteoblasts.	naringin	15-23	secreted phosphoprotein 1	Homo sapiens	125-136
18495116-6	2008	In addition, naringin also prevented the decreasing of BMP-2 and bone loss inducing by ovariectomy in vivo.	naringin	13-21	bone morphogenetic protein 2	Homo sapiens	55-60
18803250-2	2008	Three citrus flavonoids - naringin, naringenin and hesperidin - have been examined for their ability to activate caspase-3, a marker of apoptosis execution, in human polymorphonuclear neutrophils in vitro, stimulated and non-stimulated with phorbol 12-myristate 13-acetate.	naringin	26-34	caspase 3	Homo sapiens	113-122
18296682-9	2008	Transfection of cells with dominant-negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression.	naringin	101-109	mitogen-activated protein kinase 1	Homo sapiens	118-121
18296682-4	2008	In addition, naringin treatment strongly induced p21WAF1 expression, independent of the p53 pathway, and downregulated expression of cyclins and cyclin dependent kinases (CDKs).	naringin	13-21	cyclin dependent kinase 2	Homo sapiens	171-175
18296682-5	2008	Moreover, treatment with naringin induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase.	naringin	25-33	mitogen-activated protein kinase 1	Homo sapiens	61-98
18296682-5	2008	Moreover, treatment with naringin induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase.	naringin	25-33	mitogen-activated protein kinase 1	Homo sapiens	100-103
18296682-5	2008	Moreover, treatment with naringin induced phosphorylation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase and c-Jun N-terminal kinase.	naringin	25-33	mitogen-activated protein kinase 14	Homo sapiens	106-109
18296682-7	2008	Consistently, blockade of ERK function reversed naringin-mediated inhibition of cell proliferation and decreased cell-cycle proteins.	naringin	48-56	mitogen-activated protein kinase 1	Homo sapiens	26-29
18296682-9	2008	Transfection of cells with dominant-negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression.	naringin	101-109	zinc fingers and homeoboxes 2	Homo sapiens	62-65
18296682-9	2008	Transfection of cells with dominant-negative Ras (RasN17) and Raf (RafS621A) mutant genes suppressed naringin-induced ERK activity and p21WAF1 expression.	naringin	101-109	zinc fingers and homeoboxes 2	Homo sapiens	67-75
18296682-10	2008	Finally, the naringin-induced reduction in cell proliferation and cell-cycle proteins also was abolished in the presence of RasN17 and RafS621A mutant genes.	naringin	13-21	zinc fingers and homeoboxes 2	Homo sapiens	135-143
18296682-11	2008	These data demonstrate that the Ras/Raf/ERK pathway participates in p21WAF1 induction, subsequently leading to a decrease in the levels of cyclin D1/CDK4 and cyclin E-CDK2 complexes and naringin-dependent inhibition of cell growth.	naringin	186-194	zinc fingers and homeoboxes 2	Homo sapiens	36-39
18296682-11	2008	These data demonstrate that the Ras/Raf/ERK pathway participates in p21WAF1 induction, subsequently leading to a decrease in the levels of cyclin D1/CDK4 and cyclin E-CDK2 complexes and naringin-dependent inhibition of cell growth.	naringin	186-194	mitogen-activated protein kinase 1	Homo sapiens	40-43
17188415-5	2007	Pretreatment with naringin (10, 20 or 40mg/kg) daily for a period of 56 days positively altered the levels of cTnT, intensity of the bands of the LDH1 and LDH2-isoenzyme and the activities of cardiac marker enzymes, ECG-patterns and lysosomal hydrolases in ISO-induced rats.	naringin	18-26	troponin T2, cardiac type	Rattus norvegicus	110-114
18451520-7	2008	Extracts having relatively strong inhibitory effects for CYP3A4 tended to contain higher amounts of naringin, bergamottin and 6",7"-dihydroxybergamottin.	naringin	100-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	57-63
17532169-1	2008	Flavanone glycosides, such as naringin and neohesperidin, are distributed in some Citrus species and have a chiral center in the C-2 position of the flavanone moiety.	naringin	30-38	complement C2	Homo sapiens	129-132
17846099-2	2008	RBP elicited broadly tuned inhibition of various bitter substances including quinine-HCl, naringin, theobromine, caffeine, glycyl-L-phenylalanine (Gly-Phe), and denatonium benzoate, whereas several other proteins, such as ovalbumin (OVA) and beta-lactoglobulin, were ineffective in reducing bitterness of these same compounds.	naringin	90-98	riboflavin binding protein	Gallus gallus	0-3
17876860-5	2007	The grapefruit constituent, quercetin, completely inhibited SULT1A1, while quercetin and naringin both partially inhibited SULT1A3.	naringin	89-97	sulfotransferase family 1A member 3	Homo sapiens	123-130
17188415-5	2007	Pretreatment with naringin (10, 20 or 40mg/kg) daily for a period of 56 days positively altered the levels of cTnT, intensity of the bands of the LDH1 and LDH2-isoenzyme and the activities of cardiac marker enzymes, ECG-patterns and lysosomal hydrolases in ISO-induced rats.	naringin	18-26	lactate dehydrogenase A	Rattus norvegicus	146-150
17188415-5	2007	Pretreatment with naringin (10, 20 or 40mg/kg) daily for a period of 56 days positively altered the levels of cTnT, intensity of the bands of the LDH1 and LDH2-isoenzyme and the activities of cardiac marker enzymes, ECG-patterns and lysosomal hydrolases in ISO-induced rats.	naringin	18-26	lactate dehydrogenase B	Rattus norvegicus	155-159
15380892-8	2004	CONCLUSION: It would appear that both naringin and lovastatin contributed to hypocholesterolemic action via down-regulated ACAT activity and higher excretion of fecal sterols in response to high-cholesterol feeding.	naringin	38-46	sterol O-acyltransferase 1	Oryctolagus cuniculus	123-127
17009338-1	2006	It was reported that paclitaxel is an inhibitor of hepatic P-glycoprotein (P-gp) and hepatic microsomal cytochrome P450 (CYP) 3A1/2, and that naringin is an inhibitor of biliary P-gp and CYP3A1/2 in rats.	naringin	142-150	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	59-73
17009338-1	2006	It was reported that paclitaxel is an inhibitor of hepatic P-glycoprotein (P-gp) and hepatic microsomal cytochrome P450 (CYP) 3A1/2, and that naringin is an inhibitor of biliary P-gp and CYP3A1/2 in rats.	naringin	142-150	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	178-182
17009338-1	2006	It was reported that paclitaxel is an inhibitor of hepatic P-glycoprotein (P-gp) and hepatic microsomal cytochrome P450 (CYP) 3A1/2, and that naringin is an inhibitor of biliary P-gp and CYP3A1/2 in rats.	naringin	142-150	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	187-193
17009338-5	2006	The significantly greater AUC could be due mainly to an inhibition of metabolism of paclitaxel via CYP3A1/2 by oral naringin.	naringin	116-124	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	99-105
17009338-6	2006	The inhibition of hepatic P-gp by oral naringin could also contribute to the significantly greater AUC of intravenous paclitaxel by oral naringin.	naringin	39-47	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	26-30
17009338-6	2006	The inhibition of hepatic P-gp by oral naringin could also contribute to the significantly greater AUC of intravenous paclitaxel by oral naringin.	naringin	137-145	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	26-30
15618000-1	2005	Epidemiological studies suggest that food rich in quercetin and naringin may protect against certain types of lung cancer, and that genotype dependent inhibition of cytochrome P450 1A1 (CYP1A1)-mediated bioactivation of procarcinogens could be the underlying mechanism.	naringin	64-72	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	186-192
15936352-6	2005	naringin inhibited the radiation-induced elevation in the lipid peroxidation as well as depletion of glutathione, glutathione peroxidase, superoxide dismutase and catalase in liver and small intestine.	naringin	0-8	catalase	Mus musculus	163-171
15911222-6	2005	However, the investigated flavonoids did show potency to inhibit OCT-mediated transport (IC50-values: quercetin<kaempferol<<naringenin<isoquercitrin<spiraeoside<<rutin<hesperetin<naringin).	naringin	206-214	plexin A2	Homo sapiens	65-68
15342961-3	2004	The flavonoid naringin prevented the effects of AICAR, okadaic acid, and microcystin on AMPK activation as well as on S6K tail phosphorylation, suggesting AMPK as a mediator of the latter.	naringin	14-22	ribosomal protein S6 kinase B1	Homo sapiens	118-121
11707699-0	2001	Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits.	naringin	0-8	ICAM-1	Oryctolagus cuniculus	62-95
15231453-7	2004	Specifically, naringin and hesperidin induced the greatest migratory response in IMCE cells at 1 microM (P < 0.01) and induced migration greater than untreated control cells (P < 0.05) but equal to HGF-treated cells.	naringin	14-22	hepatocyte growth factor	Mus musculus	204-207
12405759-0	2002	Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator.	naringin	17-25	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	125-139
12405759-5	2002	The blood-brain barrier penetration of naringin may be enhanced by P-glycoprotein inhibitor; however, the pathway of hepatobiliary excretion of naringin may not be related to the P-glycoprotein.	naringin	39-47	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	67-81
12095991-6	2002	Okadaic acid induced a naringin-sensitive phosphorylation of AMP-activated protein kinase (AMPK), the stress-activated protein kinases SEK1 and JNK, and S6 kinase.	naringin	23-31	mitogen activated protein kinase kinase 4	Rattus norvegicus	135-139
12095991-6	2002	Okadaic acid induced a naringin-sensitive phosphorylation of AMP-activated protein kinase (AMPK), the stress-activated protein kinases SEK1 and JNK, and S6 kinase.	naringin	23-31	mitogen-activated protein kinase 8	Rattus norvegicus	144-147
12095991-6	2002	Okadaic acid induced a naringin-sensitive phosphorylation of AMP-activated protein kinase (AMPK), the stress-activated protein kinases SEK1 and JNK, and S6 kinase.	naringin	23-31	ribosomal protein S6 kinase B1	Rattus norvegicus	153-162
11814474-4	2002	Probucol and naringin supplementation led to an increase in the hepatic superoxide dismutase (SOD) and catalase (CAT) activities, and a decrease in the hepatic mitochondrial hydrogen peroxide (H(2)O(2)) content compared to the HC-control group.	naringin	13-21	catalase	Oryctolagus cuniculus	103-111
11814474-4	2002	Probucol and naringin supplementation led to an increase in the hepatic superoxide dismutase (SOD) and catalase (CAT) activities, and a decrease in the hepatic mitochondrial hydrogen peroxide (H(2)O(2)) content compared to the HC-control group.	naringin	13-21	catalase	Oryctolagus cuniculus	113-116
11814474-8	2002	CONCLUSIONS: The probucol supplement was very potent in the antioxidative defense system, whereas naringin exhibited a comparable antioxidant capacity based on increasing the gene expressions in the antioxidant enzymes, while also increasing the hepatic SOD and CAT activities, sparing plasma vitamin E, and decreasing the hepatic mitochondrial H(2)O(2) content.	naringin	98-106	catalase	Oryctolagus cuniculus	262-265
11720089-5	2001	The naringin supplementation significantly increased the activities of both hepatic SOD and catalase by 33% and 20%, respectively, whereas the lovastatin supplementation only increased the catalase activity by 23% compared to control group.	naringin	4-12	catalase	Oryctolagus cuniculus	92-100
11720089-11	2001	Accordingly, these results would appear to indicate that naringin, a citrus bioflavonoid, plays an important role in regulating antioxidative capacities by increasing the SOD and catalase activities, up-regulating the gene expressions of SOD, catalase, and GSH-Px, and protecting the plasma vitamin E.	naringin	57-65	catalase	Oryctolagus cuniculus	179-187
11720089-11	2001	Accordingly, these results would appear to indicate that naringin, a citrus bioflavonoid, plays an important role in regulating antioxidative capacities by increasing the SOD and catalase activities, up-regulating the gene expressions of SOD, catalase, and GSH-Px, and protecting the plasma vitamin E.	naringin	57-65	catalase	Oryctolagus cuniculus	243-251
14765287-6	2004	In addition, naringin markedly suppressed TNF-alpha and normalized the activated states of blood coagulation factors such as prothrombin time, fibrinogen concentration and platelet numbers caused by infection.	naringin	13-21	tumor necrosis factor	Mus musculus	42-51
12967034-0	2003	Naringin and naringenin inhibit nitrite-induced methemoglobin formation.	naringin	0-8	hemoglobin subunit gamma 2	Homo sapiens	48-61
12967034-1	2003	Naringin and naringenin protect hemoglobin from nitrite-induced oxidation to methemoglobin.	naringin	0-8	hemoglobin subunit gamma 2	Homo sapiens	77-90
12576520-5	2003	However, the preincubation of H2O2-treated EC with the flavonoids hesperedin, naringin, and quercetin strongly inhibited AT activity and activated TAL by 290%, 340%, and 250%, respectively.	naringin	78-86	transaldolase 1	Homo sapiens	147-150
11707699-9	2001	Naringin treatment inhibited hypercholesterolemia-induced intercellular adhesion molecule-1 (ICAM-1) expression on endothelial cells.	naringin	0-8	ICAM-1	Oryctolagus cuniculus	58-91
11707699-9	2001	Naringin treatment inhibited hypercholesterolemia-induced intercellular adhesion molecule-1 (ICAM-1) expression on endothelial cells.	naringin	0-8	ICAM-1	Oryctolagus cuniculus	93-99
11707699-11	2001	Naringin significantly reduced fatty streak formation and neointimal macrophage infiltration and also inhibited the expression of ICAM-1 in endothelial cells, suggesting that suppression of ICAM-1 contributed to the antiatherogenic effect.	naringin	0-8	ICAM-1	Oryctolagus cuniculus	130-136
11707699-11	2001	Naringin significantly reduced fatty streak formation and neointimal macrophage infiltration and also inhibited the expression of ICAM-1 in endothelial cells, suggesting that suppression of ICAM-1 contributed to the antiatherogenic effect.	naringin	0-8	ICAM-1	Oryctolagus cuniculus	190-196
11506811-4	2001	It has been suggested that the effect may be related to the inhibition of the human enzyme Cytochrome P450 (CYP) 3A4 by Nar, an enzyme with a high aminoacid sequence homology with the Cyp3a in mouse.	naringin	120-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-116
11737987-5	2001	RESULTS: The results showed that the inhibition of quinine 3-hydroxylation (CYP3A4 activity) by bergapten (67%), and quercetin (55%) was greater than naringenin (39%) and naringin (6%), at the same inhibitor concentration of 100 M. The results also demonstrated that the furan ring in the furanocoumarins enhanced the inhibitory effect on CYP3A4 activity.	naringin	171-179	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	76-82
11506811-4	2001	It has been suggested that the effect may be related to the inhibition of the human enzyme Cytochrome P450 (CYP) 3A4 by Nar, an enzyme with a high aminoacid sequence homology with the Cyp3a in mouse.	naringin	120-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	184-189
10193661-1	1999	Suppressive effects of naringin on lipopolysaccharide-induced tumor necrosis factor (TNF) release followed by liver injury were investigated.	naringin	23-31	tumor necrosis factor	Mus musculus	62-83
11396955-0	2001	Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.	naringin	46-54	sterol O-acyltransferase 1	Oryctolagus cuniculus	95-99
11396955-0	2001	Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.	naringin	46-54	vascular cell adhesion protein 1	Oryctolagus cuniculus	111-117
11396955-0	2001	Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits.	naringin	46-54	C-C motif chemokine 2	Oryctolagus cuniculus	122-127
11396955-5	2001	Hepatic acyl-CoA:cholesterol acyltransferase (ACAT) activity was slightly low in naringin (5.0%)- and naringenin (15.0%)-fed rabbits, compared to control group.	naringin	81-89	sterol O-acyltransferase 1	Oryctolagus cuniculus	8-44
11396955-5	2001	Hepatic acyl-CoA:cholesterol acyltransferase (ACAT) activity was slightly low in naringin (5.0%)- and naringenin (15.0%)-fed rabbits, compared to control group.	naringin	81-89	sterol O-acyltransferase 1	Oryctolagus cuniculus	46-50
11396955-8	2001	These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.	naringin	81-89	vascular cell adhesion protein 1	Oryctolagus cuniculus	188-194
11396955-8	2001	These results suggest that the anti-atherogenic effect of the citrus flavonoids, naringin and naringenin, is involved with a decreased hepatic ACAT activity and with the downregulation of VCAM-1 and MCP-1 gene expression.	naringin	81-89	C-C motif chemokine 2	Oryctolagus cuniculus	199-204
10193661-9	1999	These results indicate that action of naringin is mediated through suppression of lipopolysaccharide-induced TNF production.	naringin	38-46	tumor necrosis factor	Mus musculus	109-112
8523269-4	1995	Some selected flavonoids such as naringin, apiin, poncirin and rutin were shown to amplify TNF release from murine macrophages in vivo in response to OK-432 as a second stimulus.	naringin	33-41	tumor necrosis factor	Mus musculus	91-94
9821810-9	1998	The present study demonstrated the existence of inhibitory components in GFJ for the P-gp function in Caco-2 cells, which are distinct from known components such as naringin or naringenin.	naringin	165-173	phosphoglycolate phosphatase	Homo sapiens	85-89
8924586-5	1996	Other flavonoids inhibited TPO by different mechanisms, such as myricetin and naringin, showed noncompetitive inhibition of tyrosine iodination with respect to iodine ion and linear mixed-type inhibition with respect to hydrogen peroxide.	naringin	78-86	thyroid peroxidase	Homo sapiens	27-30
9480906-5	1998	or with a flavonoid, naringin, were completely or partly protective respectively against the OA-mediated suppression of CYP2B10 mRNA.	naringin	21-29	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	120-127
9875509-2	1998	Rutin, hesperidin, naringin and poncirin were transformed to their aglycones by the bacteria producing alpha-rhamnosidase and beta-glucosidase or endo-beta-glucosidase, and baicalin, puerarin and daidzin were transformed to their aglycones by the bacteria producing beta-glucuronidase, C-glycosidase and beta-glycosidase, respectively.	naringin	19-27	glucuronidase beta	Homo sapiens	266-284
33807218-10	2021	In the breast muscle, both hesperidin and naringin increased fatty acid synthase (FASN) expression and hesperidin increased the expression of adiponectin.	naringin	42-50	fatty acid synthase	Gallus gallus	61-80
33807218-10	2021	In the breast muscle, both hesperidin and naringin increased fatty acid synthase (FASN) expression and hesperidin increased the expression of adiponectin.	naringin	42-50	fatty acid synthase	Gallus gallus	82-86
33034258-0	2022	In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer.	naringin	22-30	phosphatase and tensin homolog	Homo sapiens	41-71
33972147-0	2022	NF-kappaB and COX-2 repression with topical application of hesperidin and naringin hydrogels augments repair and regeneration of deep dermal wounds.	naringin	74-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
33972147-0	2022	NF-kappaB and COX-2 repression with topical application of hesperidin and naringin hydrogels augments repair and regeneration of deep dermal wounds.	naringin	74-82	cytochrome c oxidase II, mitochondrial	Mus musculus	14-19
33972147-10	2022	The hesperidin/naringin hydrogel suppressed NF-kappaB and COX-2 expression on days 6 and 12.	naringin	15-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
33972147-10	2022	The hesperidin/naringin hydrogel suppressed NF-kappaB and COX-2 expression on days 6 and 12.	naringin	15-23	cytochrome c oxidase II, mitochondrial	Mus musculus	58-63
33034258-0	2022	In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer.	naringin	22-30	phosphatase and tensin homolog	Homo sapiens	73-77
34780892-3	2021	Ram1 is a less acidic- and heat-active enzyme than Ram2 and exhibited a high activity towards pNP-alpha-L-rhamnopyranoside, but it was unable to hydrolyze neither rutinose, naringin or rutin.	naringin	173-181	alpha-L-rhamnosidase	Lactobacillus plantarum WCFS1	51-55
34525226-0	2022	Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signaling.	naringin	0-8	Janus kinase 2	Rattus norvegicus	85-89
34525226-0	2022	Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signaling.	naringin	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	90-95
34525226-11	2022	We found that naringin suppressed the activation of the JAK2/STAT3 pathway.	naringin	14-22	Janus kinase 2	Rattus norvegicus	56-60
34525226-11	2022	We found that naringin suppressed the activation of the JAK2/STAT3 pathway.	naringin	14-22	signal transducer and activator of transcription 3	Rattus norvegicus	61-66
34525226-14	2022	Collectively, naringin promotes BMSC osteogenic differentiation to ameliorate osteoporosis development by targeting JAK2/STAT3 signaling.	naringin	14-22	Janus kinase 2	Rattus norvegicus	116-120
34525226-14	2022	Collectively, naringin promotes BMSC osteogenic differentiation to ameliorate osteoporosis development by targeting JAK2/STAT3 signaling.	naringin	14-22	signal transducer and activator of transcription 3	Rattus norvegicus	121-126
34601070-7	2021	RESULTS: The lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75microM and 100 microM), quercetin (75 and 100 microM) and glycyrrhizic acid (50 microM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 microM), sinomenine (50, 75, and 100 microM), quercetin (75 and 100 microM) and naringin (50 microM).	naringin	376-384	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	30-36
34890288-2	2022	NAR blocked the enhancement in the number of osteoclasts and adipocytes and the decrease in the number of osteocytes and osteocalcin (+) cells caused by FRD.	naringin	0-3	bone gamma-carboxyglutamate protein	Homo sapiens	121-132
34265522-4	2021	From the nine compounds tested, naringin, paeoniflorin, beta-ecdysterone, 18beta-glycyrrhizic acid, amygdalin, albiflorin, and saikosaponin A downregulated FMO3 activity and reduced TMAO biosynthesis.	naringin	32-40	flavin containing dimethylaniline monoxygenase 3	Homo sapiens	156-160
34723490-7	2021	Pretreatment with methylpiperidinopyrazole (MPP), a specific inhibitor of ERalpha, attenuated naringin-induced augmentations in ERalpha transactivation activity, ALP gene expression, and cell mineralization.	naringin	94-102	estrogen receptor 1	Homo sapiens	74-81
34906296-0	2021	(Naringin inhibits the proliferation and invasion of Eca109 esophageal cancer cells and promotes its apoptosis by blocking JAK/STAT signal pathway).	naringin	1-9	signal transducer and activator of transcription 3	Homo sapiens	127-131
34723490-0	2021	Naringin Improves Osteoblast Mineralization and Bone Healing and Strength through Regulating Estrogen Receptor Alpha-Dependent Alkaline Phosphatase Gene Expression.	naringin	0-8	estrogen receptor 1 (alpha)	Mus musculus	93-116
34723490-7	2021	Pretreatment with methylpiperidinopyrazole (MPP), a specific inhibitor of ERalpha, attenuated naringin-induced augmentations in ERalpha transactivation activity, ALP gene expression, and cell mineralization.	naringin	94-102	estrogen receptor 1	Homo sapiens	128-135
34723490-5	2021	In parallel, exposure to naringin enhanced translocation of estrogen receptor alpha (ERalpha) to nuclei and its transactivation activity.	naringin	25-33	estrogen receptor 1 (alpha)	Mus musculus	60-83
34723490-7	2021	Pretreatment with methylpiperidinopyrazole (MPP), a specific inhibitor of ERalpha, attenuated naringin-induced augmentations in ERalpha transactivation activity, ALP gene expression, and cell mineralization.	naringin	94-102	alkaline phosphatase, placental	Homo sapiens	162-165
34723490-5	2021	In parallel, exposure to naringin enhanced translocation of estrogen receptor alpha (ERalpha) to nuclei and its transactivation activity.	naringin	25-33	estrogen receptor 1	Homo sapiens	85-92
34723490-11	2021	Therefore, naringin could improve osteoblast mineralization and bone healing via regulating ERalpha-dependent ALP gene expression.	naringin	11-19	estrogen receptor 1 (alpha)	Mus musculus	92-99
34723490-6	2021	Sequentially, naringin induced alkaline phosphatase (ALP) mRNA and protein expression and its enzyme activity.	naringin	14-22	alkaline phosphatase, placental	Homo sapiens	53-56
34723490-11	2021	Therefore, naringin could improve osteoblast mineralization and bone healing via regulating ERalpha-dependent ALP gene expression.	naringin	11-19	alkaline phosphatase, placental	Homo sapiens	110-113
34854271-0	2021	The effects of naringenin and naringin on the glucose uptake and AMPK phosphorylation in high glucose treated HepG2 cells.	naringin	30-38	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	65-69
34728718-11	2021	MD simulation validated the stability of four chemicals at the MAPK6 binding pockets, including Assafoetidinol A (ASA), Naringin (NAR), Rutin (RUT), and Tomatine (TOM).	naringin	120-128	mitogen-activated protein kinase 6	Homo sapiens	63-68
34728718-11	2021	MD simulation validated the stability of four chemicals at the MAPK6 binding pockets, including Assafoetidinol A (ASA), Naringin (NAR), Rutin (RUT), and Tomatine (TOM).	naringin	130-133	mitogen-activated protein kinase 6	Homo sapiens	63-68
34536756-5	2021	When compared to the MTX-treated rats, MTX+NG significantly reduced the levels of urea, creatinine, MDA, NO, TNFalpha, IL-6, and caspase-3 activity.	naringin	43-45	tumor necrosis factor	Rattus norvegicus	109-117
34536756-5	2021	When compared to the MTX-treated rats, MTX+NG significantly reduced the levels of urea, creatinine, MDA, NO, TNFalpha, IL-6, and caspase-3 activity.	naringin	43-45	interleukin 6	Rattus norvegicus	119-123
34536756-5	2021	When compared to the MTX-treated rats, MTX+NG significantly reduced the levels of urea, creatinine, MDA, NO, TNFalpha, IL-6, and caspase-3 activity.	naringin	43-45	caspase 3	Rattus norvegicus	129-138
34854271-3	2021	OBJECTIVE: This study examined the relationship between glucose uptake and AMP-activated protein kinase (AMPK) phosphorylation by naringenin and naringin in high glucose-treated HepG2 cells.	naringin	145-153	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	75-103
34854271-3	2021	OBJECTIVE: This study examined the relationship between glucose uptake and AMP-activated protein kinase (AMPK) phosphorylation by naringenin and naringin in high glucose-treated HepG2 cells.	naringin	145-153	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	105-109
34854271-9	2021	Molecular docking analysis showed that both naringenin and naringin bind to the gamma-subunit of AMPK with high binding affinities.	naringin	59-67	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	97-101
34854271-11	2021	Therefore, both naringenin and naringin could be positive modulators of AMPK activation, which enhance glucose uptake regardless of insulin stimulation in high glucose-treated HepG2 cells.	naringin	31-39	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	72-76
34854271-12	2021	CONCLUSIONS: The increased phosphorylation of AMPK at Thr172 by naringenin and naringin might enhance glucose uptake regardless of insulin stimulation in high glucose treated HepG2 cells.	naringin	79-87	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	46-50
34490484-0	2021	Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro-death autophagy.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	76-79
34490484-10	2021	Further mechanistic studies demonstrated that Nar blocked the PI3K/AKT pathway, activated cell autophagy and stimulated the expression of apoptosis-associated protein cleaved caspase 3 and Bax, but decreased the expression of Bcl-2.	naringin	46-49	AKT serine/threonine kinase 1	Homo sapiens	67-70
34586803-5	2021	Moreover, naringin increased the concentration of serum adiponectin and activated the expression of AdipoR1, APPL1, AMPK, and PGC-1alpha.	naringin	10-18	adiponectin receptor 1	Mus musculus	100-107
34490484-10	2021	Further mechanistic studies demonstrated that Nar blocked the PI3K/AKT pathway, activated cell autophagy and stimulated the expression of apoptosis-associated protein cleaved caspase 3 and Bax, but decreased the expression of Bcl-2.	naringin	46-49	BCL2 associated X, apoptosis regulator	Homo sapiens	189-192
34490484-10	2021	Further mechanistic studies demonstrated that Nar blocked the PI3K/AKT pathway, activated cell autophagy and stimulated the expression of apoptosis-associated protein cleaved caspase 3 and Bax, but decreased the expression of Bcl-2.	naringin	46-49	BCL2 apoptosis regulator	Homo sapiens	226-231
34586803-5	2021	Moreover, naringin increased the concentration of serum adiponectin and activated the expression of AdipoR1, APPL1, AMPK, and PGC-1alpha.	naringin	10-18	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	Mus musculus	109-114
34586803-5	2021	Moreover, naringin increased the concentration of serum adiponectin and activated the expression of AdipoR1, APPL1, AMPK, and PGC-1alpha.	naringin	10-18	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	126-136
34586803-6	2021	Furthermore, by the in vitro experiment and AdipoR1 knockdown, we found that inhibition of the AdipoR1 signaling pathway significantly reduced the effect of naringin on slow-twitch fiber-/fast-twitch fiber-related gene and protein expression.	naringin	157-165	adiponectin receptor 1	Mus musculus	44-51
34586803-6	2021	Furthermore, by the in vitro experiment and AdipoR1 knockdown, we found that inhibition of the AdipoR1 signaling pathway significantly reduced the effect of naringin on slow-twitch fiber-/fast-twitch fiber-related gene and protein expression.	naringin	157-165	adiponectin receptor 1	Mus musculus	95-102
34586803-7	2021	In conclusion, our results indicated that naringin could induce skeletal muscle fiber transition from fast twitch to slow twitch via the AdipoR1 signaling pathway.	naringin	42-50	adiponectin receptor 1	Mus musculus	137-144
34504431-8	2021	The naringin-induced alleviation of colitis was significantly inhibited by the PPAR-gamma inhibitor BADGE.	naringin	4-12	peroxisome proliferator activated receptor gamma	Homo sapiens	79-89
34738432-7	2021	The results showed that narirutin, naringin, naringenin, poncirin, oxypeucedanin, and eriodictyol-7-O-glucoside had significant correlations with and contributed to the expression of AQP2 in kidney, AQP3 in colon, and AQP5 in submandibular gland, which were the main dryness components in Aurantii Fructus.	naringin	35-43	aquaporin 2	Rattus norvegicus	183-187
34586803-3	2021	Here, we discovered that oral administration of naringin increased the low-speed running time, four-limb hanging time, body oxygen consumption in mice, enhanced aerobic enzyme activity, MyHC I expression, and slow-twitch fiber percentage in mice skeletal muscle.	naringin	48-56	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	186-192
34586803-4	2021	By contrast, naringin decreased alpha-GPDH enzyme activity, MyHC IIb expression, and fast-twitch fiber percentage.	naringin	13-21	myosin, heavy polypeptide 4, skeletal muscle	Mus musculus	60-68
34586803-5	2021	Moreover, naringin increased the concentration of serum adiponectin and activated the expression of AdipoR1, APPL1, AMPK, and PGC-1alpha.	naringin	10-18	adiponectin, C1Q and collagen domain containing	Mus musculus	56-67
34504431-10	2021	Naringin suppressed LPS-induced high expression of NF-kappaB-p65, which was inhibited by small interfering RNA targeting PPAR-gamma.	naringin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	121-131
34504431-11	2021	Our study clarifies detailed mechanisms underlying naringin-induced therapeutic effects on mice colitis, and PPAR-gamma was found to be the main target of naringin by functional experiments both in vivo and in vitro.	naringin	155-163	peroxisome proliferator activated receptor gamma	Mus musculus	109-119
34497520-7	2021	In addition, naringin reduced calpain activity, decreased cardiac injury, increased cell viability, and restored the protein expression of Kir6.2, SUR1, and SUR2 subunits of the KATP channels.	naringin	13-21	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	139-145
34335261-9	2021	In particular, in HUVECs, Naringin significantly suppressed the mesenchymal marker expression induced by TGFbeta1 treatment, enhanced the endothelial marker expression, and inhibited the activation of ERK and NF-kappaB signaling pathways.	naringin	26-34	transforming growth factor beta 1	Homo sapiens	105-113
34497520-7	2021	In addition, naringin reduced calpain activity, decreased cardiac injury, increased cell viability, and restored the protein expression of Kir6.2, SUR1, and SUR2 subunits of the KATP channels.	naringin	13-21	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	147-151
34497520-7	2021	In addition, naringin reduced calpain activity, decreased cardiac injury, increased cell viability, and restored the protein expression of Kir6.2, SUR1, and SUR2 subunits of the KATP channels.	naringin	13-21	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	Mus musculus	157-161
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	PDZ and LIM domain 3	Rattus norvegicus	142-145
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	gamma-glutamyltransferase 1	Rattus norvegicus	147-150
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	tumor necrosis factor	Rattus norvegicus	169-178
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	interleukin 17A	Rattus norvegicus	184-189
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	243-246
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	caspase 3	Rattus norvegicus	251-260
34131434-0	2021	Naringin attenuates rat myocardial ischemia/reperfusion injury via PI3K/Akt pathway-mediated inhibition of apoptosis, oxidative stress and autophagy.	naringin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
34131434-10	2021	However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin-1, along with the LC3BII/LC3BI ratio.	naringin	61-64	AKT serine/threonine kinase 1	Rattus norvegicus	14-17
34131434-10	2021	However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin-1, along with the LC3BII/LC3BI ratio.	naringin	61-64	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
34131434-10	2021	However, PI3K/Akt inhibitor (LY294002) partially reduced the NRG induced phosphorylation of Akt and the reduction in beclin-1, along with the LC3BII/LC3BI ratio.	naringin	61-64	beclin 1	Rattus norvegicus	117-125
34284270-0	2021	Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1alpha signaling pathway in mice and C2C12 myotubes.	naringin	0-8	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	68-78
34284270-7	2021	In conclusion, naringin promotes the transformation of skeletal muscle fibers from type II to type I through AMPK/PGC-1alpha signaling pathway, which not only enriches the nutritional and physiological functions of naringin, but also provides a theoretical basis for the regulation of muscle fiber type transformation by nutritional approaches.	naringin	15-23	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	114-124
34589273-0	2021	Naringin improves sepsis-induced intestinal injury by modulating macrophage polarization via PPARgamma/miR-21 axis.	naringin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	93-102
34589273-0	2021	Naringin improves sepsis-induced intestinal injury by modulating macrophage polarization via PPARgamma/miR-21 axis.	naringin	0-8	microRNA 21a	Mus musculus	103-109
34589273-9	2021	Mechanistically, PPARgamma inhibition attenuated the promotion of M2 polarization caused by naringin, and the naringin/PPARgamma regulatory work was compromised by miR-21 inhibition.	naringin	92-100	peroxisome proliferator activated receptor gamma	Mus musculus	17-26
34589273-10	2021	The present study suggested that naringin promoted M2 polarization via the PPARgamma/miR-21 axis, thus relieving sepsis-induced intestinal injury.	naringin	33-41	peroxisome proliferator activated receptor gamma	Mus musculus	75-84
34589273-10	2021	The present study suggested that naringin promoted M2 polarization via the PPARgamma/miR-21 axis, thus relieving sepsis-induced intestinal injury.	naringin	33-41	microRNA 21a	Mus musculus	85-91
34335261-9	2021	In particular, in HUVECs, Naringin significantly suppressed the mesenchymal marker expression induced by TGFbeta1 treatment, enhanced the endothelial marker expression, and inhibited the activation of ERK and NF-kappaB signaling pathways.	naringin	26-34	mitogen-activated protein kinase 1	Homo sapiens	201-204
34335261-10	2021	To conclude, this study provided novel evidence suggesting the beneficial effects of Naringin in PAH through the inhibition of the ERK and NF-kappaB signaling pathways and the EndMT progression in pulmonary arteries.	naringin	85-93	mitogen-activated protein kinase 1	Homo sapiens	131-134
34306372-0	2021	Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway.	naringin	22-30	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
34276359-11	2021	In addition, Abeta plaque numbers in CA1, CA3, and DG areas of the hippocampus decreased significantly following treatment with 30 or 60 mg/kg/day naringin.	naringin	147-155	carbonic anhydrase 1	Mus musculus	37-40
34276359-11	2021	In addition, Abeta plaque numbers in CA1, CA3, and DG areas of the hippocampus decreased significantly following treatment with 30 or 60 mg/kg/day naringin.	naringin	147-155	carbonic anhydrase 3	Mus musculus	42-45
34313040-8	2021	RESULTS: Naringenin and naringin inhibited both lipid accumulation and TG content, increased phosphorylation levels of both AMPK and ACC and decreased the expression level of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) in 3T3-L1 adipocytes.	naringin	24-32	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	175-215
34313040-8	2021	RESULTS: Naringenin and naringin inhibited both lipid accumulation and TG content, increased phosphorylation levels of both AMPK and ACC and decreased the expression level of 3-hydroxy-3-methylglutaryl CoA reductase (HMGCR) in 3T3-L1 adipocytes.	naringin	24-32	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	217-222
34306372-10	2021	Compared with the model group, the expression of PI3K/AKT/mTOR pathway related phosphorylated proteins, the proliferation and differentiation abilities of osteoblasts, the expression of autophagosome and autophagy related factors were all increased in the Naringin group, but contrary results were found in the LY294002 group (all P<0.05).	naringin	256-264	AKT serine/threonine kinase 1	Rattus norvegicus	54-57
34306372-10	2021	Compared with the model group, the expression of PI3K/AKT/mTOR pathway related phosphorylated proteins, the proliferation and differentiation abilities of osteoblasts, the expression of autophagosome and autophagy related factors were all increased in the Naringin group, but contrary results were found in the LY294002 group (all P<0.05).	naringin	256-264	mechanistic target of rapamycin kinase	Rattus norvegicus	58-62
34306372-13	2021	CONCLUSION: Naringin exerts protective effects in GIOP by the PI3K/AKT/mTOR pathway, which may be related to autophagy induction and enhanced proliferation of osteoblasts.	naringin	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
34306372-13	2021	CONCLUSION: Naringin exerts protective effects in GIOP by the PI3K/AKT/mTOR pathway, which may be related to autophagy induction and enhanced proliferation of osteoblasts.	naringin	12-20	mechanistic target of rapamycin kinase	Rattus norvegicus	71-75
34306372-0	2021	Protective effects of naringin on glucocorticoid-induced osteoporosis through regulating the PI3K/Akt/mTOR signaling pathway.	naringin	22-30	mechanistic target of rapamycin kinase	Rattus norvegicus	102-106
34306372-1	2021	OBJECTIVE: To investigate the protective effects of Naringin on glucocorticoid-induced osteoporosis (GIOP) through the PI3K/AKT/mTOR signaling pathway in vivo and in vitro.	naringin	52-60	AKT serine/threonine kinase 1	Rattus norvegicus	124-127
34306372-1	2021	OBJECTIVE: To investigate the protective effects of Naringin on glucocorticoid-induced osteoporosis (GIOP) through the PI3K/AKT/mTOR signaling pathway in vivo and in vitro.	naringin	52-60	mechanistic target of rapamycin kinase	Rattus norvegicus	128-132
34522243-12	2021	Results: NRG significantly attenuated HG-induced increases in leptin and Ob-R expression.	naringin	9-12	leptin	Rattus norvegicus	62-68
34522243-0	2021	Naringin attenuates high glucose-induced injuries and inflammation by modulating the leptin-JAK2/STAT3 pathway in H9c2 cardiac cells.	naringin	0-8	leptin	Rattus norvegicus	85-91
34522243-0	2021	Naringin attenuates high glucose-induced injuries and inflammation by modulating the leptin-JAK2/STAT3 pathway in H9c2 cardiac cells.	naringin	0-8	Janus kinase 2	Rattus norvegicus	92-96
34522243-0	2021	Naringin attenuates high glucose-induced injuries and inflammation by modulating the leptin-JAK2/STAT3 pathway in H9c2 cardiac cells.	naringin	0-8	signal transducer and activator of transcription 3	Rattus norvegicus	97-102
34522243-12	2021	Results: NRG significantly attenuated HG-induced increases in leptin and Ob-R expression.	naringin	9-12	leptin receptor	Rattus norvegicus	73-77
35179299-0	2022	Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.	naringin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
35189328-3	2022	In recent years, multiple studies using various in vitro and rodent models have revealed new mechanisms underlying the hypolipidemic effects of naringin and naringenin, including regulation of lipid digestion, reverse cholesterol transport, and LDL receptor expression.	naringin	144-152	low density lipoprotein receptor	Homo sapiens	245-257
35179299-0	2022	Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.	naringin	0-8	ChaC, cation transport regulator 2	Mus musculus	84-89
35179299-8	2022	Notably, CHAC2 knockdown inhibited Nrf2 activation and naringin-mediated antioxidant, antiinflammatory, and antiapoptotic effects in APAP-induced liver injury.	naringin	55-63	ChaC, cation transport regulator 2	Mus musculus	9-14
35179299-9	2022	Likewise, si-Nrf2 blocked the protective effect of naringin against APAP-induced liver injury.	naringin	51-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
35179299-10	2022	Collectively, our results indicate that naringin may be a potent CHAC2 activator, alleviating APAP-induced hepatitis via CHAC2-mediated activation of the Nrf2 pathway.	naringin	40-48	ChaC, cation transport regulator 2	Mus musculus	65-70
35179299-10	2022	Collectively, our results indicate that naringin may be a potent CHAC2 activator, alleviating APAP-induced hepatitis via CHAC2-mediated activation of the Nrf2 pathway.	naringin	40-48	ChaC, cation transport regulator 2	Mus musculus	121-126
35179299-10	2022	Collectively, our results indicate that naringin may be a potent CHAC2 activator, alleviating APAP-induced hepatitis via CHAC2-mediated activation of the Nrf2 pathway.	naringin	40-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
35583493-10	2022	Similarly, Naringin-treated samples could decrease TGF-beta levels.	naringin	11-19	transforming growth factor alpha	Mus musculus	51-59
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	glycogen synthase kinase 3 alpha	Homo sapiens	94-102
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	Janus kinase 2	Homo sapiens	184-188
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	signal transducer and activator of transcription 3	Homo sapiens	189-194
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	notch receptor 1	Homo sapiens	281-287
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	mitogen-activated protein kinase 14	Homo sapiens	335-343
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	caspase 3	Homo sapiens	348-357
35529937-0	2022	Naringin Alleviates H2O2-Inhibited Osteogenic Differentiation of Human Adipose-Derived Stromal Cells via Wnt/beta-Catenin Signaling.	naringin	0-8	catenin beta 1	Homo sapiens	109-121
35529937-4	2022	In addition, we also observed that the impaired extracellular matrix mineralization and ALP activity in H2O2-stimulated ADSCs-OD were notably rescued by NAR pretreatment.	naringin	153-156	ATHS	Homo sapiens	88-91
35529937-5	2022	Moreover, the effects of H2O2 exposure on Wnt/beta-catenin signaling in ADSCs-OD were largely reversed by NAR pretreatment.	naringin	106-109	catenin beta 1	Homo sapiens	46-58
35181124-0	2022	Retraction notice to "Protective effect of naringin on small intestine injury in NSAIDs related enteropathy by regulating ghrelin/GHS-R signaling pathway" (Life Sci.	naringin	43-51	growth hormone secretagogue receptor	Homo sapiens	130-135
35416858-0	2022	Naringin attenuates acute myocardial ischemia-reperfusion injury via miR- 126/GSK-3beta/beta-catenin signaling pathway.	naringin	0-8	microRNA 126	Homo sapiens	69-77
35478969-0	2022	Naringin Mediates Adult Hippocampal Neurogenesis for Antidepression via Activating CREB Signaling.	naringin	0-8	cAMP responsive element binding protein 1	Mus musculus	83-87
35478969-2	2022	In this study, we tested the hypothesis that naringin, a natural medicinal compound, could promote adult hippocampal neurogenesis and improve depression-like behaviors via regulating the BDNF/TrkB/CREB signaling pathway.	naringin	45-53	brain derived neurotrophic factor	Mus musculus	187-191
35478969-2	2022	In this study, we tested the hypothesis that naringin, a natural medicinal compound, could promote adult hippocampal neurogenesis and improve depression-like behaviors via regulating the BDNF/TrkB/CREB signaling pathway.	naringin	45-53	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	192-196
35478969-2	2022	In this study, we tested the hypothesis that naringin, a natural medicinal compound, could promote adult hippocampal neurogenesis and improve depression-like behaviors via regulating the BDNF/TrkB/CREB signaling pathway.	naringin	45-53	cAMP responsive element binding protein 1	Mus musculus	197-201
35478969-8	2022	Meanwhile, naringin treatment increased phosphorylation of cAMP response element binding protein (CREB) but had no effect on the expression of brain-derived neurotrophic factor and phosphorylation of TrkB in the hippocampus of CORT-induced depressive mice.	naringin	11-19	cAMP responsive element binding protein 1	Mus musculus	59-96
35478969-8	2022	Meanwhile, naringin treatment increased phosphorylation of cAMP response element binding protein (CREB) but had no effect on the expression of brain-derived neurotrophic factor and phosphorylation of TrkB in the hippocampus of CORT-induced depressive mice.	naringin	11-19	cAMP responsive element binding protein 1	Mus musculus	98-102
35478969-9	2022	Co-treatment of CREB inhibitor 666-15, rather than TrkB inhibitor Cyc-B, abolished the neurogenesis-promoting and antidepressant effects of naringin.	naringin	140-148	cAMP responsive element binding protein 1	Mus musculus	16-20
35478969-10	2022	Taken together, naringin has antidepressant and anxiolytic effects, and the underlying mechanisms could be attributed to enhance hippocampal neurogenesis via activating CREB signaling.	naringin	16-24	cAMP responsive element binding protein 1	Mus musculus	169-173
35268078-11	2022	Such protection can be explained by the anti-oxidative capacity of CPE, likely due to its bioactives, including naringin (7.74 mg/g CPE).	naringin	112-120	carboxypeptidase E	Mus musculus	67-70
35268078-11	2022	Such protection can be explained by the anti-oxidative capacity of CPE, likely due to its bioactives, including naringin (7.74 mg/g CPE).	naringin	112-120	carboxypeptidase E	Mus musculus	132-135
35068607-3	2022	The aim of this study was to examine the molecular recognition site for naringin and naringenin on the HMGR and TOPOII enzymes of eleven Candida species and one phytopathogen, U. maydis, and evaluate yeast susceptibility to these flavonoids.	naringin	72-80	high mobility group AT-hook 1	Homo sapiens	103-107
35068607-11	2022	Based on the present findings, naringin and naringenin could possibly be effective for treating diseases caused by pathogenic yeasts of the Candida species and U. maydis, presumably by inhibition of their HMGR and TOPOII enzymes.	naringin	31-39	high mobility group AT-hook 1	Homo sapiens	205-209
35496302-0	2022	Naringin Interferes Doxorubicin-Induced Myocardial Injury by Promoting the Expression of ECHS1.	naringin	0-8	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	Mus musculus	89-94
35496302-9	2022	Inhibition of ECHS1 could interfere the effect of Naringin on DOX-induced myocardial injury.	naringin	50-58	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	Mus musculus	14-19
34978114-9	2022	Meantime, the results of competition experiment suggested that liquiritin apioside share different binding sites with naringin and 5-fluorouridine, which are significant for the structure stability of SOD1.	naringin	118-126	superoxide dismutase 1	Homo sapiens	201-205
35268795-5	2022	Increased levels of MMP-2, 9, 14, TIMP-2, VEGF-A, and VEGF-R1 were induced by naringin in the HaCaT cells.	naringin	78-86	matrix metallopeptidase 2	Homo sapiens	20-32
35268795-5	2022	Increased levels of MMP-2, 9, 14, TIMP-2, VEGF-A, and VEGF-R1 were induced by naringin in the HaCaT cells.	naringin	78-86	TIMP metallopeptidase inhibitor 2	Homo sapiens	34-40
35268795-5	2022	Increased levels of MMP-2, 9, 14, TIMP-2, VEGF-A, and VEGF-R1 were induced by naringin in the HaCaT cells.	naringin	78-86	vascular endothelial growth factor A	Homo sapiens	42-46
35268795-5	2022	Increased levels of MMP-2, 9, 14, TIMP-2, VEGF-A, and VEGF-R1 were induced by naringin in the HaCaT cells.	naringin	78-86	fms related receptor tyrosine kinase 1	Homo sapiens	54-61
35268795-7	2022	In line with this, VEGF-R3 levels, but not VEGF-R1 and 2 levels, increased soon after stimulation; although the increase subsided after 36 h. Additionally, naringin cream upregulated wound healing in vitro.	naringin	156-164	fms related receptor tyrosine kinase 4	Homo sapiens	19-26
35265264-0	2022	Naringin protects human nucleus pulposus cells against TNF-alpha-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation.	naringin	0-8	tumor necrosis factor	Homo sapiens	55-64
35265264-0	2022	Naringin protects human nucleus pulposus cells against TNF-alpha-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation.	naringin	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	171-175
35265264-0	2022	Naringin protects human nucleus pulposus cells against TNF-alpha-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation.	naringin	0-8	sirtuin 1	Homo sapiens	176-181
35265264-4	2022	The results showed that significantly increased autophagic flux was observed in NP cells treated with naringin, with pronounced decreases in the inflammatory response and oxidative stress, which rescued the disturbed cellular homeostasis induced by TNF-alpha activation.	naringin	102-110	tumor necrosis factor	Homo sapiens	249-258
35265264-7	2022	Either AMPK inhibition by BML-275 or SIRT1 silencing partially counteracted naringin-induced autophagic flux enhancement.	naringin	76-84	sirtuin 1	Homo sapiens	37-42
35265264-8	2022	These findings indicate that naringin boosts autophagic flux through SIRT1 upregulation via AMPK activation, thus protecting NP cells against inflammatory response, oxidative stress, and impaired cellular homeostasis.	naringin	29-37	sirtuin 1	Homo sapiens	69-74
35265264-8	2022	These findings indicate that naringin boosts autophagic flux through SIRT1 upregulation via AMPK activation, thus protecting NP cells against inflammatory response, oxidative stress, and impaired cellular homeostasis.	naringin	29-37	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	92-96
35416858-0	2022	Naringin attenuates acute myocardial ischemia-reperfusion injury via miR- 126/GSK-3beta/beta-catenin signaling pathway.	naringin	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	78-87
35416858-0	2022	Naringin attenuates acute myocardial ischemia-reperfusion injury via miR- 126/GSK-3beta/beta-catenin signaling pathway.	naringin	0-8	catenin beta 1	Homo sapiens	88-100
35416858-12	2022	Also, it was found that miR-126 can bind GSK-3beta and downregulate its expression, suggesting that naringin could decrease GSK-3beta activity.	naringin	100-108	microRNA 126	Homo sapiens	24-31
35416858-12	2022	Also, it was found that miR-126 can bind GSK-3beta and downregulate its expression, suggesting that naringin could decrease GSK-3beta activity.	naringin	100-108	glycogen synthase kinase 3 alpha	Homo sapiens	41-50
35416858-12	2022	Also, it was found that miR-126 can bind GSK-3beta and downregulate its expression, suggesting that naringin could decrease GSK-3beta activity.	naringin	100-108	glycogen synthase kinase 3 alpha	Homo sapiens	124-133
35416858-13	2022	Next, we discovered that naringin increased beta-catenin activity in cardiomyocytes treated with OGD/R by inhibiting GSK-3beta expression.	naringin	25-33	catenin beta 1	Homo sapiens	44-56
35416858-13	2022	Next, we discovered that naringin increased beta-catenin activity in cardiomyocytes treated with OGD/R by inhibiting GSK-3beta expression.	naringin	25-33	glycogen synthase kinase 3 alpha	Homo sapiens	117-126
35416858-15	2022	CONCLUSIONS: Naringin preconditioning can reduce myocardial I/R injury via regulating miR-126/GSK-3beta/beta-catenin signaling pathway, and this chemical can be used to treat acute myocardial infarction.	naringin	13-21	microRNA 126	Homo sapiens	86-93
35416858-15	2022	CONCLUSIONS: Naringin preconditioning can reduce myocardial I/R injury via regulating miR-126/GSK-3beta/beta-catenin signaling pathway, and this chemical can be used to treat acute myocardial infarction.	naringin	13-21	glycogen synthase kinase 3 alpha	Homo sapiens	94-103
35416858-15	2022	CONCLUSIONS: Naringin preconditioning can reduce myocardial I/R injury via regulating miR-126/GSK-3beta/beta-catenin signaling pathway, and this chemical can be used to treat acute myocardial infarction.	naringin	13-21	catenin beta 1	Homo sapiens	104-116
35128266-11	2022	Among the dereplicated compounds, hesperidin, naringin, and rutin have been established as promising inducer compounds for the chemopreventive marker NQO1.	naringin	46-54	NAD(P)H dehydrogenase, quinone 1	Mus musculus	150-154
35157175-9	2022	The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines (COX-2, iNOS, IL-1beta and IL-6) induced by LPS in Raw macrophage cell line, and may restrain cytokine through inhibiting HMGB1 expression in a mouse model.	naringin	63-71	cytochrome c oxidase II, mitochondrial	Mus musculus	135-140
35157175-9	2022	The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines (COX-2, iNOS, IL-1beta and IL-6) induced by LPS in Raw macrophage cell line, and may restrain cytokine through inhibiting HMGB1 expression in a mouse model.	naringin	63-71	nitric oxide synthase 2, inducible	Mus musculus	142-146
35157175-9	2022	The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines (COX-2, iNOS, IL-1beta and IL-6) induced by LPS in Raw macrophage cell line, and may restrain cytokine through inhibiting HMGB1 expression in a mouse model.	naringin	63-71	interleukin 1 alpha	Mus musculus	148-156
35157175-9	2022	The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines (COX-2, iNOS, IL-1beta and IL-6) induced by LPS in Raw macrophage cell line, and may restrain cytokine through inhibiting HMGB1 expression in a mouse model.	naringin	63-71	interleukin 6	Mus musculus	161-165
35157175-9	2022	The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines (COX-2, iNOS, IL-1beta and IL-6) induced by LPS in Raw macrophage cell line, and may restrain cytokine through inhibiting HMGB1 expression in a mouse model.	naringin	63-71	high mobility group box 1	Mus musculus	256-261
35591936-1	2022	Objective: Based on the expression changes in the TGF-beta/ALK5/Smad2/3 signal transduction pathway, the repair of cartilage injury in the rabbit knee joint was investigated and evaluated by oral administration of naringin in combination with acellular dermal matrix implantation.	naringin	214-222	protransforming growth factor alpha	Oryctolagus cuniculus	50-58
34643308-6	2022	In SKOV3 cells treated with naringin, the expression of TRIM39, which binds P21 and inhibits P21 degradation, was significantly elevated.	naringin	28-36	tripartite motif containing 39	Homo sapiens	56-62
34643308-11	2022	When naringin, a PTEN agonist, was added to SKOV3 cells in which TRIM39 protein was interfered with, the expression of P21 was significantly lower than that in the control group, and the number of senescent ovarian cancer cells was significantly diminished.	naringin	5-13	phosphatase and tensin homolog	Homo sapiens	17-21
34643308-11	2022	When naringin, a PTEN agonist, was added to SKOV3 cells in which TRIM39 protein was interfered with, the expression of P21 was significantly lower than that in the control group, and the number of senescent ovarian cancer cells was significantly diminished.	naringin	5-13	tripartite motif containing 39	Homo sapiens	65-71
35591936-1	2022	Objective: Based on the expression changes in the TGF-beta/ALK5/Smad2/3 signal transduction pathway, the repair of cartilage injury in the rabbit knee joint was investigated and evaluated by oral administration of naringin in combination with acellular dermal matrix implantation.	naringin	214-222	mothers against decapentaplegic homolog 2	Oryctolagus cuniculus	64-71
35591936-11	2022	Conclusions: Oral administration of naringin, the active ingredient of Rhizoma Drynariae, combined with acellular dermal matrix can achieve better repair effects in both joint structure repair and cartilage quality repair at the defect site when repairing cartilage defects in rabbit knees, and the generation of this effect may be caused by the activation of the TGF-beta/ALK5/Smad2/3 signal transduction pathway by naringin, resulting in the increased expression of TGF-beta2, TGF-beta3, and Sox-9 in cartilage defects.	naringin	36-44	protransforming growth factor alpha	Oryctolagus cuniculus	364-372
35591936-11	2022	Conclusions: Oral administration of naringin, the active ingredient of Rhizoma Drynariae, combined with acellular dermal matrix can achieve better repair effects in both joint structure repair and cartilage quality repair at the defect site when repairing cartilage defects in rabbit knees, and the generation of this effect may be caused by the activation of the TGF-beta/ALK5/Smad2/3 signal transduction pathway by naringin, resulting in the increased expression of TGF-beta2, TGF-beta3, and Sox-9 in cartilage defects.	naringin	36-44	mothers against decapentaplegic homolog 2	Oryctolagus cuniculus	378-385
35591936-11	2022	Conclusions: Oral administration of naringin, the active ingredient of Rhizoma Drynariae, combined with acellular dermal matrix can achieve better repair effects in both joint structure repair and cartilage quality repair at the defect site when repairing cartilage defects in rabbit knees, and the generation of this effect may be caused by the activation of the TGF-beta/ALK5/Smad2/3 signal transduction pathway by naringin, resulting in the increased expression of TGF-beta2, TGF-beta3, and Sox-9 in cartilage defects.	naringin	36-44	LOW QUALITY PROTEIN: transcription factor SOX-9	Oryctolagus cuniculus	494-499
34054546-13	2021	In vitro studies revealed that naringin exposure was found to promote apoptosis of RA-FLS, increased the activation of caspase-3, and increased the ratio of Bax/Bcl-2 in a dose-dependent manner.	naringin	31-39	caspase 3	Homo sapiens	119-128
33907819-0	2021	Naringin protects H9C2 cardiomyocytes from chemical hypoxia-induced injury by promoting the autophagic flux via the activation of the HIF-1alpha/BNIP3 signaling pathway.	naringin	0-8	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	134-144
33907819-0	2021	Naringin protects H9C2 cardiomyocytes from chemical hypoxia-induced injury by promoting the autophagic flux via the activation of the HIF-1alpha/BNIP3 signaling pathway.	naringin	0-8	BCL2 interacting protein 3	Rattus norvegicus	145-150
33907819-4	2021	The role of autophagy and the hypoxia-inducible factor-1alpha (HIF-1alpha)/Bcl-2/BCL2 interacting protein 3 (BNIP3) signaling pathway in the protective effects of naringin were also assessed.	naringin	163-171	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	63-73
33907819-4	2021	The role of autophagy and the hypoxia-inducible factor-1alpha (HIF-1alpha)/Bcl-2/BCL2 interacting protein 3 (BNIP3) signaling pathway in the protective effects of naringin were also assessed.	naringin	163-171	BCL2, apoptosis regulator	Rattus norvegicus	75-80
33907819-4	2021	The role of autophagy and the hypoxia-inducible factor-1alpha (HIF-1alpha)/Bcl-2/BCL2 interacting protein 3 (BNIP3) signaling pathway in the protective effects of naringin were also assessed.	naringin	163-171	BCL2 interacting protein 3	Rattus norvegicus	109-114
33907819-5	2021	The results revealed that naringin pre-treatment significantly attenuated the CoCl2-induced cytotoxicity and apoptosis, and also decreased caspase-3 activity, which had been increased by CoCl2.	naringin	26-34	caspase 3	Rattus norvegicus	139-148
33907819-10	2021	Furthermore, naringin pre-treatment exacerbated Beclin 1 expression and the increased IL3B-II/IL3B-I ratio, and reduced p62 expression in CoCl2-treated H9C2 cells.	naringin	13-21	beclin 1	Rattus norvegicus	48-56
33907819-10	2021	Furthermore, naringin pre-treatment exacerbated Beclin 1 expression and the increased IL3B-II/IL3B-I ratio, and reduced p62 expression in CoCl2-treated H9C2 cells.	naringin	13-21	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	120-123
33907819-12	2021	Moreover, naringin treatment resulted in upregulated expression levels of HIF-1alpha and BNIP3 in the CoCl2-treated H9C2 cells.	naringin	10-18	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	74-84
33907819-12	2021	Moreover, naringin treatment resulted in upregulated expression levels of HIF-1alpha and BNIP3 in the CoCl2-treated H9C2 cells.	naringin	10-18	BCL2 interacting protein 3	Rattus norvegicus	89-94
33992719-9	2021	Pretreatment with naringin significantly (p < 0.05) abolish CYCP-induced changes in the activities of serum and hepatic ALT, AST, GGT, ALP, and LDH.	naringin	18-26	gamma-glutamyltransferase 1	Rattus norvegicus	130-133
33992719-9	2021	Pretreatment with naringin significantly (p < 0.05) abolish CYCP-induced changes in the activities of serum and hepatic ALT, AST, GGT, ALP, and LDH.	naringin	18-26	PDZ and LIM domain 3	Rattus norvegicus	135-138
34054546-13	2021	In vitro studies revealed that naringin exposure was found to promote apoptosis of RA-FLS, increased the activation of caspase-3, and increased the ratio of Bax/Bcl-2 in a dose-dependent manner.	naringin	31-39	BCL2 associated X, apoptosis regulator	Homo sapiens	157-160
34054546-13	2021	In vitro studies revealed that naringin exposure was found to promote apoptosis of RA-FLS, increased the activation of caspase-3, and increased the ratio of Bax/Bcl-2 in a dose-dependent manner.	naringin	31-39	BCL2 apoptosis regulator	Homo sapiens	161-166
34054546-14	2021	Furthermore, treatment of naringin attenuated the production of inflammatory cytokines and matrix metalloproteinases (MMPs) in TNF-alpha-induced RA-FLS.	naringin	26-34	matrix metallopeptidase 9	Homo sapiens	118-122
34054546-14	2021	Furthermore, treatment of naringin attenuated the production of inflammatory cytokines and matrix metalloproteinases (MMPs) in TNF-alpha-induced RA-FLS.	naringin	26-34	tumor necrosis factor	Homo sapiens	127-136
34054546-15	2021	Moreover, treatment of naringin inhibited the phosphorylation of Akt and ERK in RA-FLS.	naringin	23-31	AKT serine/threonine kinase 1	Homo sapiens	65-68
34054546-15	2021	Moreover, treatment of naringin inhibited the phosphorylation of Akt and ERK in RA-FLS.	naringin	23-31	mitogen-activated protein kinase 1	Homo sapiens	73-76
34054546-17	2021	Naringin inhibits inflammation and MMPs production and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways.	naringin	0-8	matrix metallopeptidase 9	Homo sapiens	35-39
34054546-17	2021	Naringin inhibits inflammation and MMPs production and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	93-96
34054546-17	2021	Naringin inhibits inflammation and MMPs production and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways.	naringin	0-8	mitogen-activated protein kinase 1	Homo sapiens	101-105
34054546-17	2021	Naringin inhibits inflammation and MMPs production and promotes apoptosis in RA-FLS via PI3K/Akt and MAPK/ERK signaling pathways.	naringin	0-8	mitogen-activated protein kinase 1	Homo sapiens	106-109
34046215-7	2021	Reduction of TNF-alpha, IL-8 as well as MDA content and elevation of IL-10 as well as SOD activity were confirmed to be caused by Nar treatment in a concentration-dependent manner.	naringin	130-133	tumor necrosis factor	Rattus norvegicus	13-22
34046215-7	2021	Reduction of TNF-alpha, IL-8 as well as MDA content and elevation of IL-10 as well as SOD activity were confirmed to be caused by Nar treatment in a concentration-dependent manner.	naringin	130-133	interleukin 10	Rattus norvegicus	69-74
33890787-4	2021	Oral naringin mainly existed in the intestine due to the high water solubility of 7-O-nohesperidoside and alleviated atherosclerosis mainly by enhancing bile acid synthesis in the gut microbiota-FXR/FGF15-CYP7A1 pathway.	naringin	5-13	nuclear receptor subfamily 1, group H, member 4	Mus musculus	195-198
33890787-4	2021	Oral naringin mainly existed in the intestine due to the high water solubility of 7-O-nohesperidoside and alleviated atherosclerosis mainly by enhancing bile acid synthesis in the gut microbiota-FXR/FGF15-CYP7A1 pathway.	naringin	5-13	fibroblast growth factor 15	Mus musculus	199-204
33890787-4	2021	Oral naringin mainly existed in the intestine due to the high water solubility of 7-O-nohesperidoside and alleviated atherosclerosis mainly by enhancing bile acid synthesis in the gut microbiota-FXR/FGF15-CYP7A1 pathway.	naringin	5-13	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	205-211
33760152-10	2021	Naringin can also affect the expression of phosphorylated-P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway.	naringin	113-121	mitogen-activated protein kinase 14	Mus musculus	58-61
33760152-10	2021	Naringin can also affect the expression of phosphorylated-P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway.	naringin	113-121	mitogen-activated protein kinase 14	Mus musculus	62-65
33907819-13	2021	The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury.	naringin	164-172	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	22-32
33907819-13	2021	The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury.	naringin	164-172	BCL2 interacting protein 3	Rattus norvegicus	33-38
33907819-13	2021	The inhibition of the HIF-1alpha/BNIP3 signaling pathway using 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (an inhibitor of HIF-1alpha) prevented the effects of naringin on the autophagic flux and reversed its protective effects against CoCl2-induced injury.	naringin	164-172	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	127-137
33907819-14	2021	Taken together, these results suggest that naringin protects the H9C2 cells against CoCl2-induced injury by enhancing the autophagic flux via the activation of the HIF-1alpha/BNIP3 signaling pathway.	naringin	43-51	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	164-174
33907819-14	2021	Taken together, these results suggest that naringin protects the H9C2 cells against CoCl2-induced injury by enhancing the autophagic flux via the activation of the HIF-1alpha/BNIP3 signaling pathway.	naringin	43-51	BCL2 interacting protein 3	Rattus norvegicus	175-180
33760152-10	2021	Naringin can also affect the expression of phosphorylated-P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway.	naringin	113-121	mitogen-activated protein kinase 14	Mus musculus	143-151
33784419-9	2021	Neohesperidin, naringin and meranzin showed inhibitory effect on acetylcholinesterase that regulates gastrointestinal motility in vitro and in silico, suggesting that these three components may be determined as the active biomarkers of Fructus Aurantii.	naringin	15-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85
33601237-8	2021	Furthermore, the naringin-promoted proliferation of the 16HBE14o- cells was associated with enhanced cell cycle progression, mRNA expression of cyclin E, and evoked calcium signaling/ERK signaling, which were all attenuated by inhibition of the TAS2R signaling pathways with specific blockers.	naringin	17-25	mitogen-activated protein kinase 1	Homo sapiens	183-186
32767187-15	2021	Our study suggests that naringin attenuated SDS-induced behavioral endophenotypes of neuropsychiatric disease through increased GAD67 synthesis, inhibition of AChE activity, oxidative, nitrergic stress, and neuroinflammatory processes in stress-sensitive brain regions.	naringin	24-32	acetylcholinesterase	Mus musculus	159-163
33760152-10	2021	Naringin can also affect the expression of phosphorylated-P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway.	naringin	0-8	mitogen-activated protein kinase 14	Mus musculus	58-61
33760152-10	2021	Naringin can also affect the expression of phosphorylated-P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway.	naringin	0-8	mitogen-activated protein kinase 14	Mus musculus	62-65
33760152-10	2021	Naringin can also affect the expression of phosphorylated-P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway.	naringin	0-8	mitogen-activated protein kinase 14	Mus musculus	143-151
32767187-13	2021	Naringin increased the levels of GAD67 and decreased AChE activities in the striatum, prefrontal cortex, and hippocampus.	naringin	0-8	acetylcholinesterase	Mus musculus	53-57
32767187-14	2021	Furthermore, naringin reduced pro-inflammatory cytokines (TNF-alpha, IL-6), malondialdehyde, nitrite concentrations, and increased glutathione levels in a region-dependent manner.	naringin	13-21	tumor necrosis factor	Mus musculus	58-67
33534126-6	2021	Naringin treatment for 14 days attenuated Abeta-induced cognitive impairments of the animals in Morris water maze (MWM) and Y-maze tests.	naringin	0-8	amyloid beta precursor protein	Rattus norvegicus	42-47
32767187-14	2021	Furthermore, naringin reduced pro-inflammatory cytokines (TNF-alpha, IL-6), malondialdehyde, nitrite concentrations, and increased glutathione levels in a region-dependent manner.	naringin	13-21	interleukin 6	Mus musculus	69-73
33618628-3	2021	After the initial virtual screening of a number of bioactive flavonoids, the binding affinity of three compounds - Naringin, Naringenin and Amentoflavone - at the active site of Mpro was investigated through MD Simulations, MM-PBSA and DFT Binding Energy calculations.	naringin	115-123	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	178-182
33618628-4	2021	From the MD trajectory analysis, Amentoflavone and Naringin showed consistent protein-ligand interactions with the aminoacid residues of the active site domains of Mpro.	naringin	51-59	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	164-168
33534126-7	2021	Further, naringin ameliorated the Abeta-induced cholinergic dysfunction in terms of decrease in the activity of choline acetyl transferase (ChAT) and level of acetylcholine (ACh) and increase in the activity of acetylcholine esterase (AChE) in rat hippocampus, prefrontal cortex, and amygdala.	naringin	9-17	amyloid beta precursor protein	Rattus norvegicus	34-39
33534126-7	2021	Further, naringin ameliorated the Abeta-induced cholinergic dysfunction in terms of decrease in the activity of choline acetyl transferase (ChAT) and level of acetylcholine (ACh) and increase in the activity of acetylcholine esterase (AChE) in rat hippocampus, prefrontal cortex, and amygdala.	naringin	9-17	choline O-acetyltransferase	Rattus norvegicus	112-138
33534126-7	2021	Further, naringin ameliorated the Abeta-induced cholinergic dysfunction in terms of decrease in the activity of choline acetyl transferase (ChAT) and level of acetylcholine (ACh) and increase in the activity of acetylcholine esterase (AChE) in rat hippocampus, prefrontal cortex, and amygdala.	naringin	9-17	choline O-acetyltransferase	Rattus norvegicus	140-144
33534126-8	2021	Furthermore, naringin attenuated Abeta-induced decrease in mitochondrial function, integrity, and bioenergetics in all the brain regions.	naringin	13-21	amyloid beta precursor protein	Rattus norvegicus	33-38
33534126-9	2021	Naringin also attenuated Abeta-induced increase in mitochondrial and cytosolic calcium level in all the brain regions.	naringin	0-8	amyloid beta precursor protein	Rattus norvegicus	25-30
33534126-10	2021	Moreover, naringin reversed Abeta-induced increase in apoptosis and level of mitochondrial calcium uniporter and decrease in the level of hemeoxygenase-1 in all the brain regions.	naringin	10-18	amyloid beta precursor protein	Rattus norvegicus	28-33
33534126-10	2021	Moreover, naringin reversed Abeta-induced increase in apoptosis and level of mitochondrial calcium uniporter and decrease in the level of hemeoxygenase-1 in all the brain regions.	naringin	10-18	heme oxygenase 1	Rattus norvegicus	138-153
33534126-11	2021	On the contrary, A779 significantly abolished the therapeutic potential of naringin on Abeta-induced alteration in behavioral, biochemical, and molecular observations in these experimental animals.	naringin	75-83	amyloid beta precursor protein	Rattus norvegicus	87-92
32979141-0	2021	Naringin Combined with NF-kappaB Inhibition and Endoplasmic Reticulum Stress Induces Apoptotic Cell Death via Oxidative Stress and the PERK/eIF2alpha/ATF4/CHOP Axis in HT29 Colon Cancer Cells.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	23-32
32979141-0	2021	Naringin Combined with NF-kappaB Inhibition and Endoplasmic Reticulum Stress Induces Apoptotic Cell Death via Oxidative Stress and the PERK/eIF2alpha/ATF4/CHOP Axis in HT29 Colon Cancer Cells.	naringin	0-8	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	135-139
32979141-0	2021	Naringin Combined with NF-kappaB Inhibition and Endoplasmic Reticulum Stress Induces Apoptotic Cell Death via Oxidative Stress and the PERK/eIF2alpha/ATF4/CHOP Axis in HT29 Colon Cancer Cells.	naringin	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	140-149
32979141-0	2021	Naringin Combined with NF-kappaB Inhibition and Endoplasmic Reticulum Stress Induces Apoptotic Cell Death via Oxidative Stress and the PERK/eIF2alpha/ATF4/CHOP Axis in HT29 Colon Cancer Cells.	naringin	0-8	activating transcription factor 4	Homo sapiens	150-154
32979141-0	2021	Naringin Combined with NF-kappaB Inhibition and Endoplasmic Reticulum Stress Induces Apoptotic Cell Death via Oxidative Stress and the PERK/eIF2alpha/ATF4/CHOP Axis in HT29 Colon Cancer Cells.	naringin	0-8	DNA damage inducible transcript 3	Homo sapiens	155-159
32979141-3	2021	Naringin combined with tunicamycin and BAY 11-7082 suppressed the proliferation of HT29 cells in a dose-dependent manner and induced particularly apoptotic death without significantly affecting healthy VSMCs according to Annexin V/PI staining and AO/EB staining analyses.	naringin	0-8	annexin A5	Homo sapiens	221-230
32979141-7	2021	In conclusion, this study found that naringin combined with tunicamycin+BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells via oxidative stress and the PERK/eIF2alpha/ATF4/CHOP pathway, suggesting that naringin combined with tunicamycin plus BAY 11-7082 could be a new combination therapy strategy for effective colon cancer treatment with minimal side effects on healthy cells.	naringin	37-45	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	181-185
32979141-7	2021	In conclusion, this study found that naringin combined with tunicamycin+BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells via oxidative stress and the PERK/eIF2alpha/ATF4/CHOP pathway, suggesting that naringin combined with tunicamycin plus BAY 11-7082 could be a new combination therapy strategy for effective colon cancer treatment with minimal side effects on healthy cells.	naringin	37-45	eukaryotic translation initiation factor 2A	Homo sapiens	186-195
32979141-7	2021	In conclusion, this study found that naringin combined with tunicamycin+BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells via oxidative stress and the PERK/eIF2alpha/ATF4/CHOP pathway, suggesting that naringin combined with tunicamycin plus BAY 11-7082 could be a new combination therapy strategy for effective colon cancer treatment with minimal side effects on healthy cells.	naringin	37-45	activating transcription factor 4	Homo sapiens	196-200
32979141-7	2021	In conclusion, this study found that naringin combined with tunicamycin+BAY 11-7082 efficiently induced apoptotic cell death in HT29 colon cancer cells via oxidative stress and the PERK/eIF2alpha/ATF4/CHOP pathway, suggesting that naringin combined with tunicamycin plus BAY 11-7082 could be a new combination therapy strategy for effective colon cancer treatment with minimal side effects on healthy cells.	naringin	37-45	DNA damage inducible transcript 3	Homo sapiens	201-205
33333047-0	2021	Protective effect of naringin on small intestine injury in NSAIDs related enteropathy by regulating ghrelin/GHS-R signaling pathway.	naringin	21-29	ghrelin and obestatin prepropeptide	Rattus norvegicus	100-107
33333047-0	2021	Protective effect of naringin on small intestine injury in NSAIDs related enteropathy by regulating ghrelin/GHS-R signaling pathway.	naringin	21-29	growth hormone secretagogue receptor	Homo sapiens	108-113
33333047-3	2021	METHODS: Naringin was used as the intervention method, observed the damage of small intestinal mucosa and detected the expression of ghrelin, GHS-R, leptin and TNF-alpha by electron microscopy, HE staining and immunohistochemistry.	naringin	9-17	ghrelin and obestatin prepropeptide	Rattus norvegicus	133-140
33333047-3	2021	METHODS: Naringin was used as the intervention method, observed the damage of small intestinal mucosa and detected the expression of ghrelin, GHS-R, leptin and TNF-alpha by electron microscopy, HE staining and immunohistochemistry.	naringin	9-17	tumor necrosis factor	Homo sapiens	160-169
32557145-8	2021	Naringin could alleviate OGD/R-induced injury via promoting the proliferation, and repressing the apoptosis of PC12 cells through regulating the expression of NFKB1 and apoptosis-associated proteins and ROS level.	naringin	0-8	nuclear factor kappa B subunit 1	Rattus norvegicus	159-164
28745128-8	2021	Additionally, the efflux of paeoniflorin and naringin were apparently reduced in the presence of P-gp inhibitor verapamil.	naringin	45-53	PGP	Canis lupus familiaris	97-101
33365066-7	2021	In addition, naringin administration reduced the expression of alpha-SMA, COL1A1, COL3A1, IL-1beta, IL-6 and TNF-alpha in the kidneys of rats following UUO.	naringin	13-21	collagen type I alpha 1 chain	Rattus norvegicus	74-80
33365066-7	2021	In addition, naringin administration reduced the expression of alpha-SMA, COL1A1, COL3A1, IL-1beta, IL-6 and TNF-alpha in the kidneys of rats following UUO.	naringin	13-21	collagen type III alpha 1 chain	Rattus norvegicus	82-88
33365066-7	2021	In addition, naringin administration reduced the expression of alpha-SMA, COL1A1, COL3A1, IL-1beta, IL-6 and TNF-alpha in the kidneys of rats following UUO.	naringin	13-21	interleukin 1 alpha	Rattus norvegicus	90-98
33365066-7	2021	In addition, naringin administration reduced the expression of alpha-SMA, COL1A1, COL3A1, IL-1beta, IL-6 and TNF-alpha in the kidneys of rats following UUO.	naringin	13-21	interleukin 6	Rattus norvegicus	100-104
33365066-7	2021	In addition, naringin administration reduced the expression of alpha-SMA, COL1A1, COL3A1, IL-1beta, IL-6 and TNF-alpha in the kidneys of rats following UUO.	naringin	13-21	tumor necrosis factor	Rattus norvegicus	109-118
33365066-9	2021	In conclusion, naringin could antagonize renal interstitial fibrosis by regulating the TGF-beta/Smad pathway and the expression of inflammatory factors.	naringin	15-23	transforming growth factor alpha	Rattus norvegicus	87-95
33365066-9	2021	In conclusion, naringin could antagonize renal interstitial fibrosis by regulating the TGF-beta/Smad pathway and the expression of inflammatory factors.	naringin	15-23	SMAD family member 4	Rattus norvegicus	96-100
33445988-7	2021	Naringin also increased superoxide dismutase expression and decreased malondialdehyde, creatine kinase, lactate dehydrogenase, and cleaved caspase-3 expression in rats with SIMD.	naringin	0-8	caspase 3	Rattus norvegicus	139-148
33445988-10	2021	Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.	naringin	0-8	Kelch-like ECH-associated protein 1	Rattus norvegicus	123-128
33445988-10	2021	Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133
33445988-10	2021	Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.	naringin	0-8	heme oxygenase 1	Rattus norvegicus	134-138
32557145-10	2021	Moreover, the depletion of NFKB1 enhanced the influences of naringin on cell proliferation and apoptosis as well as the expression of apoptosis-related proteins and ROS level.	naringin	60-68	nuclear factor kappa B subunit 1	Rattus norvegicus	27-32
32557145-11	2021	Western blotting indicated that both naringin treatment and depletion of NFKB1 could increase the expression of HIF-1alpha, p-AKT, and p-mTOR compared with OGD/R group.	naringin	37-45	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	112-122
32557145-11	2021	Western blotting indicated that both naringin treatment and depletion of NFKB1 could increase the expression of HIF-1alpha, p-AKT, and p-mTOR compared with OGD/R group.	naringin	37-45	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
32557145-11	2021	Western blotting indicated that both naringin treatment and depletion of NFKB1 could increase the expression of HIF-1alpha, p-AKT, and p-mTOR compared with OGD/R group.	naringin	37-45	mechanistic target of rapamycin kinase	Rattus norvegicus	137-141
32557145-14	2021	In conclusion, naringin could prevent the OGD/R-induced injury in PC12 cells in vitro by targeting NFKB1 and regulating HIF-1alpha/AKT/mTOR-signaling pathway, which might provide novel ideas for the therapy of cerebral ischemia-reperfusion (I/R) injury.	naringin	15-23	nuclear factor kappa B subunit 1	Rattus norvegicus	99-104
32557145-14	2021	In conclusion, naringin could prevent the OGD/R-induced injury in PC12 cells in vitro by targeting NFKB1 and regulating HIF-1alpha/AKT/mTOR-signaling pathway, which might provide novel ideas for the therapy of cerebral ischemia-reperfusion (I/R) injury.	naringin	15-23	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	120-130
32557145-14	2021	In conclusion, naringin could prevent the OGD/R-induced injury in PC12 cells in vitro by targeting NFKB1 and regulating HIF-1alpha/AKT/mTOR-signaling pathway, which might provide novel ideas for the therapy of cerebral ischemia-reperfusion (I/R) injury.	naringin	15-23	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
32557145-14	2021	In conclusion, naringin could prevent the OGD/R-induced injury in PC12 cells in vitro by targeting NFKB1 and regulating HIF-1alpha/AKT/mTOR-signaling pathway, which might provide novel ideas for the therapy of cerebral ischemia-reperfusion (I/R) injury.	naringin	15-23	mechanistic target of rapamycin kinase	Rattus norvegicus	135-139
33302980-5	2020	In this study, the naringin-induced OPG/RANKL effects and its underlying mechanism were studied in fibroblasts from periprosthetic membrane.	naringin	19-27	TNF receptor superfamily member 11b	Homo sapiens	36-39
33424398-7	2021	The flavonoid naringin showed the least binding energy of -9.8 Kcal/mol with the spike protein which was compared with the standard drug, dexamethasone which is being repurposed to treat critically ill patients.	naringin	14-22	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	81-86
33302980-5	2020	In this study, the naringin-induced OPG/RANKL effects and its underlying mechanism were studied in fibroblasts from periprosthetic membrane.	naringin	19-27	TNF superfamily member 11	Homo sapiens	40-45
33302980-9	2020	RESULTS: The mRNA and protein levels of OPG were enhanced by naringin in a dose-dependent manner compared to that of the non-treated control.	naringin	61-69	TNF receptor superfamily member 11b	Homo sapiens	40-43
33302980-11	2020	Importantly, DKK-1 attenuated OPG expression in fibroblasts under naringin treatment.	naringin	66-74	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	13-18
33302980-11	2020	Importantly, DKK-1 attenuated OPG expression in fibroblasts under naringin treatment.	naringin	66-74	TNF receptor superfamily member 11b	Homo sapiens	30-33
33302980-12	2020	Moreover, naringin stimulated the gene expression of beta-catenin and cyclin D1 in fibroblasts, and the effect could be inhibited by DKK-1.	naringin	10-18	catenin beta 1	Homo sapiens	53-65
33302980-12	2020	Moreover, naringin stimulated the gene expression of beta-catenin and cyclin D1 in fibroblasts, and the effect could be inhibited by DKK-1.	naringin	10-18	cyclin D1	Homo sapiens	70-79
33302980-12	2020	Moreover, naringin stimulated the gene expression of beta-catenin and cyclin D1 in fibroblasts, and the effect could be inhibited by DKK-1.	naringin	10-18	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	133-138
33210911-6	2020	Other flavanone derivatives from grapefruit juice also inhibited OATP1A2/OATP2B1-mediated transport (order of inhibitory potency: naringenin > narirutin > naringin).	naringin	155-163	solute carrier organic anion transporter family member 1A2	Homo sapiens	65-72
33343723-3	2020	Administration of naringin increases in vitro expression of bone morphogenetic proteins (BMPs) and activation of the Wnt/beta-catenin and extracellular signal-related kinase (Erk) pathways, thereby promoting osteoblastic proliferation and differentiation from stem cell precursors for bone formation.	naringin	18-26	catenin beta 1	Homo sapiens	121-133
33343723-3	2020	Administration of naringin increases in vitro expression of bone morphogenetic proteins (BMPs) and activation of the Wnt/beta-catenin and extracellular signal-related kinase (Erk) pathways, thereby promoting osteoblastic proliferation and differentiation from stem cell precursors for bone formation.	naringin	18-26	mitogen-activated protein kinase 1	Homo sapiens	138-173
33343723-3	2020	Administration of naringin increases in vitro expression of bone morphogenetic proteins (BMPs) and activation of the Wnt/beta-catenin and extracellular signal-related kinase (Erk) pathways, thereby promoting osteoblastic proliferation and differentiation from stem cell precursors for bone formation.	naringin	18-26	mitogen-activated protein kinase 1	Homo sapiens	175-178
33343723-4	2020	Naringin also inhibits osteoclastogenesis by both modifying RANK/RANKL interactions and inducing apoptosis in osteoclasts in vitro.	naringin	0-8	TNF superfamily member 11	Homo sapiens	65-70
33343723-5	2020	In addition, naringin acts on the estrogen receptor in bone to mimic the native bone-preserving effects of estrogen, with few systemic side effects on other estrogen-sensitive tissues.	naringin	13-21	estrogen receptor 1	Homo sapiens	34-51
33210911-6	2020	Other flavanone derivatives from grapefruit juice also inhibited OATP1A2/OATP2B1-mediated transport (order of inhibitory potency: naringenin > narirutin > naringin).	naringin	155-163	solute carrier organic anion transporter family member 2B1	Homo sapiens	73-80
32736047-10	2020	TF and naringin demonstrated a certain inhibitory effect on alpha-glucosidase and a weaker inhibitory effect on alpha-amylase.	naringin	7-15	sucrase isomaltase (alpha-glucosidase)	Mus musculus	60-77
33281780-0	2020	Naringin Attenuates High Fat Diet Induced Non-alcoholic Fatty Liver Disease and Gut Bacterial Dysbiosis in Mice.	naringin	0-8	CD36 molecule	Mus musculus	25-28
33107729-9	2020	In addition, naringin facilitated reverse cholesterol transport by downregulating PCSK9/IDOL.	naringin	13-21	proprotein convertase subtilisin/kexin type 9	Mus musculus	82-87
33107729-9	2020	In addition, naringin facilitated reverse cholesterol transport by downregulating PCSK9/IDOL.	naringin	13-21	myosin regulatory light chain interacting protein	Mus musculus	88-92
33302980-13	2020	CONCLUSION: The results indicated that naringin enhanced OPG expression through Wnt/beta-catenin signaling pathway in fibroblasts from periprosthetic membrane, which may be useful to inhibit periprosthetic osteolysis during aseptic loosening after total joint arthroplasty.	naringin	39-47	TNF receptor superfamily member 11b	Homo sapiens	57-60
33302980-13	2020	CONCLUSION: The results indicated that naringin enhanced OPG expression through Wnt/beta-catenin signaling pathway in fibroblasts from periprosthetic membrane, which may be useful to inhibit periprosthetic osteolysis during aseptic loosening after total joint arthroplasty.	naringin	39-47	catenin beta 1	Homo sapiens	84-96
32952649-11	2020	One potential mechanism of naringin action may be through activation and continuous regulation of the TGF-beta superfamily signaling pathway, which can promote BMSCs to differentiate into chondrocytes.	naringin	27-35	protransforming growth factor alpha	Oryctolagus cuniculus	102-110
31294637-0	2020	Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.	naringin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
33086930-2	2020	Our previous studies showed that the traditional Chinese medicine naringin significantly inhibited the proliferation of platinum-resistant ovarian cancer cells in vitro, and that the mechanism may be related to the NF-kappaB pathway.	naringin	66-74	nuclear factor kappa B subunit 1	Homo sapiens	215-224
33192517-3	2020	Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes.	naringin	54-62	caspase 3	Homo sapiens	155-171
33107729-0	2020	Naringin Alleviates Atherosclerosis in ApoE-/- Mice by Regulating Cholesterol Metabolism Involved in Gut Microbiota Remodeling.	naringin	0-8	apolipoprotein E	Mus musculus	39-43
33107729-4	2020	Naringin significantly alleviated atherosclerosis and lowered the serum and liver cholesterol levels by 24.04 and 28.37% in ApoE-/- mice fed with a high-fat diet.	naringin	0-8	apolipoprotein E	Mus musculus	124-128
33107729-8	2020	Naringin modulated the abundances of bile salt hydrolase- and 7alpha-dehydroxylase-producing bacteria, promoting bile acid synthesis from cholesterol by upregulating CYP7A1 via suppression of the FXR/FGF15 pathway.	naringin	0-8	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	166-172
33107729-8	2020	Naringin modulated the abundances of bile salt hydrolase- and 7alpha-dehydroxylase-producing bacteria, promoting bile acid synthesis from cholesterol by upregulating CYP7A1 via suppression of the FXR/FGF15 pathway.	naringin	0-8	nuclear receptor subfamily 1, group H, member 4	Mus musculus	196-199
33107729-8	2020	Naringin modulated the abundances of bile salt hydrolase- and 7alpha-dehydroxylase-producing bacteria, promoting bile acid synthesis from cholesterol by upregulating CYP7A1 via suppression of the FXR/FGF15 pathway.	naringin	0-8	fibroblast growth factor 15	Mus musculus	200-205
33142463-5	2020	Besides, the expression level of IL-1beta mRNA showed significant increase during dihydromyricetin, chlorogenic acid, naringin, imiquimod, thymopentin, beta-D-Glucan, astragalus polysacharin, astragalus saponin I, astragalus flavone, curcumin, CpG-DNA-2, and LPS treatment.	naringin	118-126	interleukin 1 alpha	Homo sapiens	33-41
32464207-0	2020	In-silico and biophysical investigation of biomolecular interaction between naringin and nsP2 of the chikungunya virus.	naringin	76-84	BCAR3 adaptor protein, NSP family member	Homo sapiens	89-93
32464207-6	2020	Using a combination of receptor-based docking and MD simulations, we identified a flavanone glycoside- naringin, which binds to nsP2 protease at nM affinity.	naringin	103-111	BCAR3 adaptor protein, NSP family member	Homo sapiens	128-132
32464207-7	2020	The biomolecular interaction between naringin and nsP2 was established through SPR.	naringin	37-45	BCAR3 adaptor protein, NSP family member	Homo sapiens	50-54
32464207-7	2020	The biomolecular interaction between naringin and nsP2 was established through SPR.	naringin	37-45	sepiapterin reductase	Homo sapiens	79-82
32464207-8	2020	As discerned through FTIR and intrinsic fluorescence studies, upon binding with naringin, a global structural change in nsP2 occurs.	naringin	80-88	ftir	None	21-25
32464207-8	2020	As discerned through FTIR and intrinsic fluorescence studies, upon binding with naringin, a global structural change in nsP2 occurs.	naringin	80-88	BCAR3 adaptor protein, NSP family member	Homo sapiens	120-124
32464207-9	2020	This structural modulation in nsP2 due to binding of naringin is likely to interfere with the normal functioning of this enzyme during the viral life cycle.	naringin	53-61	BCAR3 adaptor protein, NSP family member	Homo sapiens	30-34
33086930-7	2020	CONCLUSIONS: Non-cytotoxic naringin reduced the expression of beta-catenin, c-Myc, and cyclin D1 in SKOV3/CDDP cells and partially reversed cisplatin resistance in SKOV3/CDDP CN 20 cells.	naringin	27-35	catenin beta 1	Homo sapiens	62-74
33086930-7	2020	CONCLUSIONS: Non-cytotoxic naringin reduced the expression of beta-catenin, c-Myc, and cyclin D1 in SKOV3/CDDP cells and partially reversed cisplatin resistance in SKOV3/CDDP CN 20 cells.	naringin	27-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	76-81
33086930-7	2020	CONCLUSIONS: Non-cytotoxic naringin reduced the expression of beta-catenin, c-Myc, and cyclin D1 in SKOV3/CDDP cells and partially reversed cisplatin resistance in SKOV3/CDDP CN 20 cells.	naringin	27-35	cyclin D1	Homo sapiens	87-96
32741259-8	2020	Based on better dock score, binding-free energy and binding interactions compared to the control molecules, six molecules (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) were found to be promising against the TMPRSS2.	naringin	162-170	transmembrane serine protease 2	Homo sapiens	234-241
32702445-0	2020	Naringin ameliorates type 2 diabetes mellitus-induced steatohepatitis by inhibiting RAGE/NF-kappaB mediated mitochondrial apoptosis.	naringin	0-8	advanced glycosylation end product-specific receptor	Rattus norvegicus	84-88
32702445-3	2020	Consequently, we aimed to decipher the effect of naringin on RAGE/NF-kappaB mediated mitochondrial apoptosis in type 2 diabetes mellitus (T2DM)-induced steatohepatitis.	naringin	49-57	advanced glycosylation end product-specific receptor	Rattus norvegicus	61-65
32901506-4	2020	Results: Knockdown of miR-96-5p in the presence of naringin was shown to reduce the expression of Foxo1 and contents of superoxide dismutase, catalase and glutathione peroxidase, yet increase lipocalin-2 expression as well as hydroxyproline and malondialdehyde contents.	naringin	51-59	microRNA 96	Mus musculus	22-28
32901506-4	2020	Results: Knockdown of miR-96-5p in the presence of naringin was shown to reduce the expression of Foxo1 and contents of superoxide dismutase, catalase and glutathione peroxidase, yet increase lipocalin-2 expression as well as hydroxyproline and malondialdehyde contents.	naringin	51-59	forkhead box O1	Mus musculus	98-103
32901506-4	2020	Results: Knockdown of miR-96-5p in the presence of naringin was shown to reduce the expression of Foxo1 and contents of superoxide dismutase, catalase and glutathione peroxidase, yet increase lipocalin-2 expression as well as hydroxyproline and malondialdehyde contents.	naringin	51-59	catalase	Mus musculus	142-150
32901506-4	2020	Results: Knockdown of miR-96-5p in the presence of naringin was shown to reduce the expression of Foxo1 and contents of superoxide dismutase, catalase and glutathione peroxidase, yet increase lipocalin-2 expression as well as hydroxyproline and malondialdehyde contents.	naringin	51-59	lipocalin 2	Mus musculus	192-203
32428650-10	2020	Also, penile expression of antigen presenting cells, CD43 transcript, caspace-9 and tumor suppressor P53 proteins were repressed on treatment with NRG.	naringin	147-150	sialophorin	Rattus norvegicus	53-57
32428650-10	2020	Also, penile expression of antigen presenting cells, CD43 transcript, caspace-9 and tumor suppressor P53 proteins were repressed on treatment with NRG.	naringin	147-150	tumor protein p53	Rattus norvegicus	84-104
32728717-0	2020	Correction: Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway.	naringin	12-20	Yes1 associated transcriptional regulator	Homo sapiens	104-107
32172062-10	2020	Naringin prevented hypertension and ocular dysfunction by depleting the activities of angiotensin-converting enzymes, arginase, aldose-reductase and phosphodiesterase-51 (PDE-51) with corresponding down-regulation of inflammatory markers including TNF-alpha and IL-B.	naringin	0-8	tumor necrosis factor	Rattus norvegicus	248-257
32428650-8	2020	NRG prevented hypertension and erectile dysfunction by inhibiting the activities of angiotensin-converting enzymes, arginase, and phosphodiesterase-51 (PDE-51) with corresponding down-regulation of inflammatory markers including TNF-alpha and IL-B.	naringin	0-3	tumor necrosis factor	Rattus norvegicus	229-238
32428650-9	2020	Additionally, hypertensive erectile dysfunction was remarkably prevented by NRG as manifested by the declined activities of AChE, MAO-A and enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA) with resultant increase in NO level.	naringin	76-79	acetylcholinesterase	Rattus norvegicus	124-128
32428650-9	2020	Additionally, hypertensive erectile dysfunction was remarkably prevented by NRG as manifested by the declined activities of AChE, MAO-A and enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA) with resultant increase in NO level.	naringin	76-79	monoamine oxidase A	Rattus norvegicus	130-135
32832002-0	2020	A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16.	naringin	19-27	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	136-142
32832002-8	2020	Naringin treatment prolonged the lifespan of long-lived glp-1 mutants, which have decreased reproductive stem cells.	naringin	0-8	glp-1/Notch intracellular domain	Caenorhabditis elegans	56-61
32832002-10	2020	Moreover, naringin could increase the mRNA expression of genes regulated by daf-16 and itself.	naringin	10-18	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	76-82
32751373-4	2020	In this work, we have used mass-spectrometry-based lipidomics to characterize the changes in the phospholipidome of proinflammatory human-macrophage-like cells (THP-1-derived and LPS+IFN-gamma-stimulated) incubated with non-cytotoxic concentrations of three flavonoids: quercetin, naringin and naringenin.	naringin	281-289	GLI family zinc finger 2	Homo sapiens	161-166
32458964-5	2020	Nar also reduced MTX-induced oxidative stress by significantly reducing liver malondialdehyde and nitric oxide content and increasing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione.	naringin	0-3	catalase	Homo sapiens	156-164
32458964-5	2020	Nar also reduced MTX-induced oxidative stress by significantly reducing liver malondialdehyde and nitric oxide content and increasing superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione.	naringin	0-3	glutathione-disulfide reductase	Homo sapiens	190-211
32458964-6	2020	In addition, Nar significantly counteracted MTX-induced increases in hepatic interleukin-6 and tumor necrosis factor-alpha.	naringin	13-16	interleukin 6	Homo sapiens	77-90
32458964-6	2020	In addition, Nar significantly counteracted MTX-induced increases in hepatic interleukin-6 and tumor necrosis factor-alpha.	naringin	13-16	tumor necrosis factor	Homo sapiens	95-122
32458964-8	2020	In contrast, in vitro MTX and/or Nar treatment of HepG2 cells for 48 h exhibited a cytotoxic effect and induced apoptosis in a dose-dependent manner mediated by a significant increase in the Bax/Bcl-2 protein expression ratio.	naringin	33-36	BCL2 associated X, apoptosis regulator	Homo sapiens	191-194
32458964-8	2020	In contrast, in vitro MTX and/or Nar treatment of HepG2 cells for 48 h exhibited a cytotoxic effect and induced apoptosis in a dose-dependent manner mediated by a significant increase in the Bax/Bcl-2 protein expression ratio.	naringin	33-36	BCL2 apoptosis regulator	Homo sapiens	195-200
32458964-9	2020	Noticeably, Nar potentiated the MTX effect on the Bax/Bcl-2 ratio.	naringin	12-15	BCL2 associated X, apoptosis regulator	Homo sapiens	50-53
32458964-9	2020	Noticeably, Nar potentiated the MTX effect on the Bax/Bcl-2 ratio.	naringin	12-15	BCL2 apoptosis regulator	Homo sapiens	54-59
32458964-11	2020	Also, our data introduce MTX and Nar as promising antiproliferative agents with a distinctive mode of action, inducing apoptosis in HepG2 tumor cells through activation of Bax and downregulation of Bcl-2 protein expression.	naringin	33-36	BCL2 associated X, apoptosis regulator	Homo sapiens	172-175
32458964-11	2020	Also, our data introduce MTX and Nar as promising antiproliferative agents with a distinctive mode of action, inducing apoptosis in HepG2 tumor cells through activation of Bax and downregulation of Bcl-2 protein expression.	naringin	33-36	BCL2 apoptosis regulator	Homo sapiens	198-203
32500755-0	2021	Naringin inhibits titanium particles-induced up-regulation of TNF-alpha and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane.	naringin	0-8	tumor necrosis factor	Homo sapiens	62-71
32500755-0	2021	Naringin inhibits titanium particles-induced up-regulation of TNF-alpha and IL-6 via the p38 MAPK pathway in fibroblasts from hip periprosthetic membrane.	naringin	0-8	interleukin 6	Homo sapiens	76-80
32500755-9	2021	RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6.	naringin	9-17	tumor necrosis factor	Homo sapiens	85-94
32500755-9	2021	RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6.	naringin	9-17	interleukin 6	Homo sapiens	99-103
32500755-9	2021	RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6.	naringin	9-17	tumor necrosis factor	Homo sapiens	224-233
32500755-9	2021	RESULTS: Naringin or SB203580 pretreatment significantly suppressed the secretion of TNF-alpha and IL-6 induced by titanium particles in fibroblasts, while inhibition of ERK or JNK pathways showed no effect on production of TNF-alpha and IL-6.	naringin	9-17	interleukin 6	Homo sapiens	238-242
32500755-10	2021	Moreover, naringin inhibited Ti particle-induced phosphorylation of p38 and p65.	naringin	10-18	mitogen-activated protein kinase 14	Homo sapiens	68-71
32500755-10	2021	Moreover, naringin inhibited Ti particle-induced phosphorylation of p38 and p65.	naringin	10-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	76-79
32500755-11	2021	CONCLUSIONS: These results indicated that naringin could inhibit Ti particle-induced inflammation in fibroblasts by inhibiting p38 MAPK/NF-kappaB p65 activity and might be a potential drug for the treatment of inflammatory periprosthetic osteolysis after arthroplasty.	naringin	42-50	RELA proto-oncogene, NF-kB subunit	Homo sapiens	146-149
32513069-0	2020	Naringin reduces body weight, plasma lipids and increases adiponectin levels in patients with dyslipidemia.	naringin	0-8	adiponectin, C1Q and collagen domain containing	Homo sapiens	58-69
32513069-2	2020	For this reason, we believe it would be interesting to study the effects of Naringin administration on body weight, BMI, lipid profile and adiponectin levels in patients with dyslipidemia, especially considering that dyslipidemias along with obesity and subsequent cardiometabolic complications are some of the most important public health issues plaguing our society today.	naringin	76-84	adiponectin, C1Q and collagen domain containing	Homo sapiens	139-150
32343512-0	2020	Naringin induces endoplasmic reticulum stress-mediated apoptosis, inhibits beta-catenin pathway and arrests cell cycle in cervical cancer cells.	naringin	0-8	catenin beta 1	Homo sapiens	75-87
32346444-0	2020	Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	71-74
32346444-0	2020	Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	75-79
32346444-2	2020	Naringin has an inhibitory effect on the PI3k/AKT/mTOR signaling pathway in various tumor cell types and the effect of naringin is closely related to the occurrence and proliferation of tumor cells.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	46-49
32346444-2	2020	Naringin has an inhibitory effect on the PI3k/AKT/mTOR signaling pathway in various tumor cell types and the effect of naringin is closely related to the occurrence and proliferation of tumor cells.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	50-54
32346444-3	2020	The aim of this present study was to investigate whether naringin could inhibit the proliferation of CRC cells by inhibiting the PI3K/AKT/mTOR signaling pathway.	naringin	57-65	AKT serine/threonine kinase 1	Homo sapiens	134-137
32346444-3	2020	The aim of this present study was to investigate whether naringin could inhibit the proliferation of CRC cells by inhibiting the PI3K/AKT/mTOR signaling pathway.	naringin	57-65	mechanistic target of rapamycin kinase	Homo sapiens	138-142
32346444-6	2020	The degree of apoptosis and the expression of apoptosis-related proteins (Bcl-2 and Bax) in CRC cells stimulated by naringin was detected using flow cytometry and western blot assays, respectively.	naringin	116-124	BCL2 apoptosis regulator	Homo sapiens	74-79
32346444-6	2020	The degree of apoptosis and the expression of apoptosis-related proteins (Bcl-2 and Bax) in CRC cells stimulated by naringin was detected using flow cytometry and western blot assays, respectively.	naringin	116-124	BCL2 associated X, apoptosis regulator	Homo sapiens	84-87
32346444-7	2020	The expression levels of PI3K/AKT/mTOR-related proteins [PI3K, AKT, mTOR, phosphorylated (p)-PI3K, p-AKT and p-mTOR] after naringin stimulation in CRC cells were detected using western blot assays.	naringin	123-131	AKT serine/threonine kinase 1	Homo sapiens	30-33
32346444-7	2020	The expression levels of PI3K/AKT/mTOR-related proteins [PI3K, AKT, mTOR, phosphorylated (p)-PI3K, p-AKT and p-mTOR] after naringin stimulation in CRC cells were detected using western blot assays.	naringin	123-131	mechanistic target of rapamycin kinase	Homo sapiens	34-38
32346444-9	2020	Naringin promoted the apoptosis of CRC cells and inhibited the activation of the PI3K/AKT/mTOR signaling pathway in a dose-dependent manner.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	86-89
31916219-13	2020	These observations indicate that naringin may exert neuroprotective activity against rotenone-induced toxicity in the animals possibly through Nrf2-mediated pathway.	naringin	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
32346444-9	2020	Naringin promoted the apoptosis of CRC cells and inhibited the activation of the PI3K/AKT/mTOR signaling pathway in a dose-dependent manner.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	90-94
32346444-10	2020	The results demonstrated that naringin may be a promising therapeutic agent for the treatment of CRC, which may inhibit the proliferation of CRC cells and induce apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway.	naringin	30-38	AKT serine/threonine kinase 1	Homo sapiens	195-198
32346444-10	2020	The results demonstrated that naringin may be a promising therapeutic agent for the treatment of CRC, which may inhibit the proliferation of CRC cells and induce apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway.	naringin	30-38	mechanistic target of rapamycin kinase	Homo sapiens	199-203
32151688-0	2020	Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3beta and Wnt/beta-catenin signaling pathways.	naringin	47-55	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
32151688-0	2020	Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3beta and Wnt/beta-catenin signaling pathways.	naringin	47-55	glycogen synthase kinase 3 alpha	Rattus norvegicus	118-127
32151688-0	2020	Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3beta and Wnt/beta-catenin signaling pathways.	naringin	47-55	Wnt family member 2	Rattus norvegicus	132-135
32151688-0	2020	Potential therapeutic antipsychotic effects of Naringin against ketamine-induced deficits in rats: Involvement of Akt/GSK-3beta and Wnt/beta-catenin signaling pathways.	naringin	47-55	catenin beta 1	Rattus norvegicus	136-148
32045600-0	2020	Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	45-48
32045600-0	2020	Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	49-53
32045600-5	2020	Moreover, Nar increases the phosphorylation levels of phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt) and mammalian rapamycin target protein (mTOR).	naringin	10-13	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	54-83
32045600-5	2020	Moreover, Nar increases the phosphorylation levels of phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt) and mammalian rapamycin target protein (mTOR).	naringin	10-13	protein tyrosine kinase 2 beta	Homo sapiens	92-108
32045600-5	2020	Moreover, Nar increases the phosphorylation levels of phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt) and mammalian rapamycin target protein (mTOR).	naringin	10-13	AKT serine/threonine kinase 1	Homo sapiens	110-113
32045600-5	2020	Moreover, Nar increases the phosphorylation levels of phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt) and mammalian rapamycin target protein (mTOR).	naringin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	155-159
32343512-4	2020	Annexin V FITC and immunoblotting analysis reveal significant apoptosis induction in cells exposed to higher doses naringin.	naringin	115-123	annexin A5	Homo sapiens	0-9
32343512-6	2020	Naringin increases the protein expression of ER stress sensors, phosphorylates eIF2alpha by and activates apoptosis-associated protein CHOP and other associated proapoptotic proteins (PARP1 and caspase-3).	naringin	0-8	eukaryotic translation initiation factor 2A	Homo sapiens	79-88
32343512-6	2020	Naringin increases the protein expression of ER stress sensors, phosphorylates eIF2alpha by and activates apoptosis-associated protein CHOP and other associated proapoptotic proteins (PARP1 and caspase-3).	naringin	0-8	DNA damage inducible transcript 3	Homo sapiens	135-139
32343512-6	2020	Naringin increases the protein expression of ER stress sensors, phosphorylates eIF2alpha by and activates apoptosis-associated protein CHOP and other associated proapoptotic proteins (PARP1 and caspase-3).	naringin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	184-189
32343512-6	2020	Naringin increases the protein expression of ER stress sensors, phosphorylates eIF2alpha by and activates apoptosis-associated protein CHOP and other associated proapoptotic proteins (PARP1 and caspase-3).	naringin	0-8	caspase 3	Homo sapiens	194-203
32343512-8	2020	Additionally, the naringin abrogates the beta-catenin pathway by decreasing the protein expression as well as phosphorylation of beta-catenin (Ser576) and GSK-3beta (Ser9) and simultaneously triggers cell cycle arrest at a G0/G1 phase by increasing the expression of cell cycle checkpoint proteins p21/cip and p27/kip.	naringin	18-26	catenin beta 1	Homo sapiens	41-53
32343512-8	2020	Additionally, the naringin abrogates the beta-catenin pathway by decreasing the protein expression as well as phosphorylation of beta-catenin (Ser576) and GSK-3beta (Ser9) and simultaneously triggers cell cycle arrest at a G0/G1 phase by increasing the expression of cell cycle checkpoint proteins p21/cip and p27/kip.	naringin	18-26	catenin beta 1	Homo sapiens	129-141
32343512-8	2020	Additionally, the naringin abrogates the beta-catenin pathway by decreasing the protein expression as well as phosphorylation of beta-catenin (Ser576) and GSK-3beta (Ser9) and simultaneously triggers cell cycle arrest at a G0/G1 phase by increasing the expression of cell cycle checkpoint proteins p21/cip and p27/kip.	naringin	18-26	glycogen synthase kinase 3 alpha	Homo sapiens	155-164
32343512-8	2020	Additionally, the naringin abrogates the beta-catenin pathway by decreasing the protein expression as well as phosphorylation of beta-catenin (Ser576) and GSK-3beta (Ser9) and simultaneously triggers cell cycle arrest at a G0/G1 phase by increasing the expression of cell cycle checkpoint proteins p21/cip and p27/kip.	naringin	18-26	H3 histone pseudogene 16	Homo sapiens	298-301
32343512-8	2020	Additionally, the naringin abrogates the beta-catenin pathway by decreasing the protein expression as well as phosphorylation of beta-catenin (Ser576) and GSK-3beta (Ser9) and simultaneously triggers cell cycle arrest at a G0/G1 phase by increasing the expression of cell cycle checkpoint proteins p21/cip and p27/kip.	naringin	18-26	dynactin subunit 6	Homo sapiens	310-313
32343512-9	2020	Naringin induces ER stress-mediated apoptosis and simultaneously abrogates Wnt/beta-catenin signaling which eventually triggers the arrest of the cell cycle at a G0/G1 phase in CC cells.	naringin	0-8	catenin beta 1	Homo sapiens	79-91
31960246-8	2020	Moreover, naringin treatment restored the development of damaged tibia bone via downregulating Ihh and upregulating PTHrP mRNA and protein expressions.	naringin	10-18	indian hedgehog	Gallus gallus	95-98
31960246-8	2020	Moreover, naringin treatment restored the development of damaged tibia bone via downregulating Ihh and upregulating PTHrP mRNA and protein expressions.	naringin	10-18	parathyroid hormone like hormone	Gallus gallus	116-121
31850758-0	2020	Protective Effect of Naringin on In Vitro Gut-Vascular Barrier Disruption of Intestinal Microvascular Endothelial Cells Induced by TNF-alpha.	naringin	21-29	tumor necrosis factor	Rattus norvegicus	131-140
32103758-0	2020	Naringin provides neuroprotection in CCL2-induced cognition impairment by attenuating neuronal apoptosis in the hippocampus.	naringin	0-8	C-C motif chemokine ligand 2	Rattus norvegicus	37-41
32103758-3	2020	Thus, this study aimed to explore the neuroprotection afforded by naringin in CCL2-induced cognitive impairment in rats.	naringin	66-74	C-C motif chemokine ligand 2	Rattus norvegicus	78-82
32103758-9	2020	RESULTS: In the MWM, the average escape latency and average swimming distance were significantly reduced and the crossing times were increased in the naringin-treated groups, compared with the CCL2 group.	naringin	150-158	C-C motif chemokine ligand 2	Rattus norvegicus	193-197
32103758-10	2020	The NORT results revealed that, compared with the CCL2 rats, the discrimination index in the naringin-treated rats increased significantly.	naringin	93-101	C-C motif chemokine ligand 2	Rattus norvegicus	50-54
32103758-14	2020	In the naringin-treated groups, the relative mRNA expression levels of caspase-8, caspase-3, and Bax were decreased, whereas that of Bcl-2 was increased.	naringin	7-15	caspase 8	Rattus norvegicus	71-80
32103758-14	2020	In the naringin-treated groups, the relative mRNA expression levels of caspase-8, caspase-3, and Bax were decreased, whereas that of Bcl-2 was increased.	naringin	7-15	caspase 3	Rattus norvegicus	82-91
32103758-14	2020	In the naringin-treated groups, the relative mRNA expression levels of caspase-8, caspase-3, and Bax were decreased, whereas that of Bcl-2 was increased.	naringin	7-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	97-100
32103758-14	2020	In the naringin-treated groups, the relative mRNA expression levels of caspase-8, caspase-3, and Bax were decreased, whereas that of Bcl-2 was increased.	naringin	7-15	BCL2, apoptosis regulator	Rattus norvegicus	133-138
32026367-7	2020	Pretreatment of isolated heart mitochondria with naringin decreased mitochondrial oxidative damage through decreasing lipid peroxidation, returned mitochondrial complex II changes, decreasing MMP collapse and ROS production, and restoration of GSH level and CAT activity.	naringin	49-57	catalase	Rattus norvegicus	258-261
31999045-4	2020	neoeriocitrin, isonaringin, naringin, hesperidin, neohesperidin, and limonin, were identified as potent acetylcholinesterase inhibitors.	naringin	18-26	acetylcholinesterase	Rattus norvegicus	104-124
32091090-6	2020	Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs.	naringin	14-22	cadherin 5	Homo sapiens	76-87
32091090-6	2020	Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs.	naringin	14-22	interleukin 1 alpha	Homo sapiens	172-180
32091090-6	2020	Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs.	naringin	14-22	interleukin 6	Homo sapiens	182-186
32091090-6	2020	Additionally, naringin restored endothelial barrier integrity by preventing VE-cadherin disassembly and F-actin remodeling, and downregulated pro-inflammatory factors like IL-1beta, IL-6, and IL-18, in the HUVECs.	naringin	14-22	interleukin 18	Homo sapiens	192-197
32091090-7	2020	We also demonstrated that naringin treatment restored ox-LDL-induced YAP (yes-associated protein) downregulation, given the YAP-shRNA attenuated cytoprotective effect of naringin on ox-LDL-induced endothelial cell injury and apoptosis.	naringin	26-34	Yes1 associated transcriptional regulator	Homo sapiens	69-72
32091090-7	2020	We also demonstrated that naringin treatment restored ox-LDL-induced YAP (yes-associated protein) downregulation, given the YAP-shRNA attenuated cytoprotective effect of naringin on ox-LDL-induced endothelial cell injury and apoptosis.	naringin	26-34	Yes1 associated transcriptional regulator	Homo sapiens	74-96
31759198-7	2020	In addition, naringin also attenuates the pro-inflammatory cytokines like TNF-alpha, AChE, Amyloid deposition and Mn concentration.	naringin	13-21	tumor necrosis factor	Rattus norvegicus	74-83
31759198-7	2020	In addition, naringin also attenuates the pro-inflammatory cytokines like TNF-alpha, AChE, Amyloid deposition and Mn concentration.	naringin	13-21	acetylcholinesterase	Rattus norvegicus	85-89
31850758-3	2020	This study aimed to investigate the distinguishing and selectively protective effects of naringin on tumor necrosis factor (TNF)-alpha-induced gut-vascular barrier disruption and elucidate the potential mechanism.	naringin	89-97	tumor necrosis factor	Rattus norvegicus	101-134
31850758-5	2020	Evans blue-albumin efflux assay showed that naringin (50 muM) evidently protected the integrity of RIMVEC monolayer barriers against TNF-alpha-induced disruption.	naringin	44-52	tumor necrosis factor	Rattus norvegicus	133-142
31850758-7	2020	Additionally, naringin protected RIMVECs from TNF-alpha-induced apoptosis and cell migration suppression (41.1 +- 2.2 vs 51.1 +- 3.5%; 61.0 +- 5.1 vs 72.2 +- 6.2%).	naringin	14-22	tumor necrosis factor	Rattus norvegicus	46-55
32329644-5	2020	Rapamycin pre-treatment with Naringin showed significant decrease in mTOR phosphorylation and increase in LC3B activation in AGS cells.	naringin	29-37	mechanistic target of rapamycin kinase	Homo sapiens	69-73
31901198-12	2020	And naringin treatment reduced apoptosis of nerve cells in rat hippocampus and the secretion of inflammatory factor such as TNF-alpha and IL-6.	naringin	4-12	tumor necrosis factor	Rattus norvegicus	124-133
31901198-12	2020	And naringin treatment reduced apoptosis of nerve cells in rat hippocampus and the secretion of inflammatory factor such as TNF-alpha and IL-6.	naringin	4-12	interleukin 6	Rattus norvegicus	138-142
31901198-14	2020	Finally, we found that naringin promoted the expression of p-AKT protein in a concentration-dependent manner and activated the PI3K/AKT pathway in OGD induced neurons.	naringin	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
31901198-14	2020	Finally, we found that naringin promoted the expression of p-AKT protein in a concentration-dependent manner and activated the PI3K/AKT pathway in OGD induced neurons.	naringin	23-31	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
32329644-5	2020	Rapamycin pre-treatment with Naringin showed significant decrease in mTOR phosphorylation and increase in LC3B activation in AGS cells.	naringin	29-37	microtubule associated protein 1 light chain 3 beta	Homo sapiens	106-110
32329644-6	2020	Decrease in mTOR phosphorylation is associated with lysosomal function activation was observed by time-dependent treatment of Naringin.	naringin	126-134	mechanistic target of rapamycin kinase	Homo sapiens	12-16
32329644-8	2020	Naringin treated AGS cells showed up-regulating BH3 domain Bad, down-regulating Bcl-xL, and Bad phosphorylation and significant mitochondrial fluorescence intensity expression.	naringin	0-8	BCL2 like 1	Homo sapiens	80-86
32329644-10	2020	Activation of ERK1/2-p38 MAPKs and production of intracellular ROS has been observed over Naringin treatment.	naringin	90-98	mitogen-activated protein kinase 3	Homo sapiens	14-20
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	interleukin 1 beta	Homo sapiens	26-43
32749127-0	2020	Naringin, a Natural Flavonoid, Modulates UVB Radiation-Induced DNA Damage and Photoaging by Modulating NER Repair and MMPS Expression in Mouse Embryonic Fibroblast Cells.	naringin	0-8	matrix metallopeptidase 13	Mus musculus	118-122
32749127-1	2020	We have proven that naringin, a phytonutrient, diminishes oxidative damage and inflammatory responses by modulating PPAR-gamma expressions in ultraviolet-B radiation (UVB)-induced NIH-3T3 cells.	naringin	20-28	peroxisome proliferator activated receptor gamma	Mus musculus	116-126
32749127-3	2020	We show that Naringin pretreatment significantly reduces UVB-induced alkaline DNA damage and potentially modulates NER gene (XPC, TFIIH, XPE, ERCC1, and GAPDH) expression, thereby augmenting DNA repair.	naringin	13-21	xeroderma pigmentosum, complementation group C	Mus musculus	125-128
32749127-3	2020	We show that Naringin pretreatment significantly reduces UVB-induced alkaline DNA damage and potentially modulates NER gene (XPC, TFIIH, XPE, ERCC1, and GAPDH) expression, thereby augmenting DNA repair.	naringin	13-21	general transcription factor IIH, polypeptide 3	Mus musculus	130-135
32749127-3	2020	We show that Naringin pretreatment significantly reduces UVB-induced alkaline DNA damage and potentially modulates NER gene (XPC, TFIIH, XPE, ERCC1, and GAPDH) expression, thereby augmenting DNA repair.	naringin	13-21	excision repair cross-complementing rodent repair deficiency, complementation group 1	Mus musculus	142-147
32749127-3	2020	We show that Naringin pretreatment significantly reduces UVB-induced alkaline DNA damage and potentially modulates NER gene (XPC, TFIIH, XPE, ERCC1, and GAPDH) expression, thereby augmenting DNA repair.	naringin	13-21	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	153-158
32749127-4	2020	We determined experimentally that naringin pretreatment prevents UVB-induced nuclear fragmentation in NIH-3T3 cells, as well as altering UVB-induced apoptotic marker (Bax, BCl-2, Caspase-9, and Caspase-3) expression in them.	naringin	34-42	BCL2-associated X protein	Mus musculus	167-170
32749127-4	2020	We determined experimentally that naringin pretreatment prevents UVB-induced nuclear fragmentation in NIH-3T3 cells, as well as altering UVB-induced apoptotic marker (Bax, BCl-2, Caspase-9, and Caspase-3) expression in them.	naringin	34-42	B cell leukemia/lymphoma 2	Mus musculus	172-177
32749127-4	2020	We determined experimentally that naringin pretreatment prevents UVB-induced nuclear fragmentation in NIH-3T3 cells, as well as altering UVB-induced apoptotic marker (Bax, BCl-2, Caspase-9, and Caspase-3) expression in them.	naringin	34-42	caspase 9	Mus musculus	179-188
32749127-4	2020	We determined experimentally that naringin pretreatment prevents UVB-induced nuclear fragmentation in NIH-3T3 cells, as well as altering UVB-induced apoptotic marker (Bax, BCl-2, Caspase-9, and Caspase-3) expression in them.	naringin	34-42	caspase 3	Mus musculus	194-203
32749127-5	2020	In addition, naringin pretreatment inhibits UVB-stimulated matrix metalloproteinase (MMP-2, MMP-9 and MMP-13) expression in these 3T3 cells.	naringin	13-21	matrix metallopeptidase 2	Mus musculus	85-90
32749127-5	2020	In addition, naringin pretreatment inhibits UVB-stimulated matrix metalloproteinase (MMP-2, MMP-9 and MMP-13) expression in these 3T3 cells.	naringin	13-21	matrix metallopeptidase 9	Mus musculus	92-97
32749127-5	2020	In addition, naringin pretreatment inhibits UVB-stimulated matrix metalloproteinase (MMP-2, MMP-9 and MMP-13) expression in these 3T3 cells.	naringin	13-21	matrix metallopeptidase 13	Mus musculus	102-108
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	interleukin 1 alpha	Homo sapiens	45-53
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	124-146
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	nuclear factor kappa B subunit 1	Homo sapiens	148-157
31927560-0	2019	Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression.	naringin	0-8	tumor protein p53	Homo sapiens	171-174
31927560-8	2019	We found that naringin could significantly reduce the expressions of matrix metalloproteinases (MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5) and inflammatory genes in IL-1ss-stimulated human NP cells, while collagen II and aggrecan were increased at mRNA and protein level.	naringin	14-22	matrix metallopeptidase 3	Homo sapiens	96-101
31927560-8	2019	We found that naringin could significantly reduce the expressions of matrix metalloproteinases (MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5) and inflammatory genes in IL-1ss-stimulated human NP cells, while collagen II and aggrecan were increased at mRNA and protein level.	naringin	14-22	matrix metallopeptidase 13	Homo sapiens	103-109
31927560-8	2019	We found that naringin could significantly reduce the expressions of matrix metalloproteinases (MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5) and inflammatory genes in IL-1ss-stimulated human NP cells, while collagen II and aggrecan were increased at mRNA and protein level.	naringin	14-22	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	111-119
31927560-8	2019	We found that naringin could significantly reduce the expressions of matrix metalloproteinases (MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5) and inflammatory genes in IL-1ss-stimulated human NP cells, while collagen II and aggrecan were increased at mRNA and protein level.	naringin	14-22	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	125-133
31727500-0	2019	Naringin inhibits thyroid cancer cell proliferation and induces cell apoptosis through repressing PI3K/AKT pathway.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	103-106
32329644-3	2020	Growth inhibition of AGS cells showed downregulation of PI3K/Akt/mTOR signaling by Naringin treatment.	naringin	83-91	AKT serine/threonine kinase 1	Homo sapiens	61-64
32329644-3	2020	Growth inhibition of AGS cells showed downregulation of PI3K/Akt/mTOR signaling by Naringin treatment.	naringin	83-91	mechanistic target of rapamycin kinase	Homo sapiens	65-69
31727500-7	2019	Results indicated that naringin dose- and time-dependently inhibited TPC-1 and SW1736 cell proliferation, and naringin dose-dependently induced TPC-1 and SW1736 cell apoptosis.	naringin	23-31	two pore segment channel 1	Homo sapiens	69-74
31727500-7	2019	Results indicated that naringin dose- and time-dependently inhibited TPC-1 and SW1736 cell proliferation, and naringin dose-dependently induced TPC-1 and SW1736 cell apoptosis.	naringin	110-118	two pore segment channel 1	Homo sapiens	144-149
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	caspase 3	Homo sapiens	80-88
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	caspase 3	Homo sapiens	98-106
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	BCL2 associated X, apoptosis regulator	Homo sapiens	111-114
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	cyclin D1	Homo sapiens	146-155
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	157-162
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	BCL2 apoptosis regulator	Homo sapiens	178-183
31604166-0	2019	Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation.	naringin	22-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-143
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	two pore segment channel 1	Homo sapiens	187-192
31604166-2	2019	The aim of the current study was to examine the effects of naringin (NAR), trimetazidine (TMZ), or their combination on the Nrf-2 expression in the kidney tissue, and myocardial injury in the renal IR injury in rats.	naringin	59-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-129
31727500-9	2019	Moreover, we found that naringin dose-dependently suppressed PI3K/AKT pathway activation in TC cells.	naringin	24-32	AKT serine/threonine kinase 1	Homo sapiens	66-69
31604166-2	2019	The aim of the current study was to examine the effects of naringin (NAR), trimetazidine (TMZ), or their combination on the Nrf-2 expression in the kidney tissue, and myocardial injury in the renal IR injury in rats.	naringin	69-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-129
31727500-10	2019	In conclusion, the data of this study suggested that naringin presented anti-tumor effects in TC cells through inhibiting TC cell proliferation and inducing cell apoptosis via regulating the expression of cell proliferation and apoptosis related genes and PI3K/AKT pathway activation.	naringin	53-61	AKT serine/threonine kinase 1	Homo sapiens	261-264
31604166-8	2019	CONCLUSION: NAR, TMZ, or their combination could attenuate the Nrf-2 expression in the kidney tissue, following the renal IR injury through inhibition of lipid peroxidase, and enhancement of antioxidant activity.	naringin	12-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-68
31694638-11	2019	When testing the interactions of these compounds with the viral envelope protein in silico by docking, only naringin and hesperidin had better scores than the theoretical threshold of - 7.0 kcal/mol (- 8.0 kcal/mol and - 8.2 kcal/mol, respectively).	naringin	108-116	endogenous retrovirus group K member 6, envelope	Homo sapiens	64-80
31781614-0	2019	Naringin Reverses High-Cholesterol Diet-Induced Vascular Dysfunction and Oxidative Stress in Rats via Regulating LOX-1 and NADPH Oxidase Subunit Expression.	naringin	0-8	oxidized low density lipoprotein receptor 1	Rattus norvegicus	113-118
31781614-10	2019	Furthermore, naringin treatment decreased LOX-1, NADPH oxidase subunits (p47phox, Nox2, and Nox4), and iNOS as well as oxidative damage markers (3-nitrotyrosine (3-NT) and 4-hydroxynonenal (4-HNE)) expression in aortic tissues from hypercholesterolaemic rats.	naringin	13-21	oxidized low density lipoprotein receptor 1	Rattus norvegicus	42-47
31781614-10	2019	Furthermore, naringin treatment decreased LOX-1, NADPH oxidase subunits (p47phox, Nox2, and Nox4), and iNOS as well as oxidative damage markers (3-nitrotyrosine (3-NT) and 4-hydroxynonenal (4-HNE)) expression in aortic tissues from hypercholesterolaemic rats.	naringin	13-21	neutrophil cytosolic factor 1	Rattus norvegicus	73-80
31781614-10	2019	Furthermore, naringin treatment decreased LOX-1, NADPH oxidase subunits (p47phox, Nox2, and Nox4), and iNOS as well as oxidative damage markers (3-nitrotyrosine (3-NT) and 4-hydroxynonenal (4-HNE)) expression in aortic tissues from hypercholesterolaemic rats.	naringin	13-21	cytochrome b-245 beta chain	Rattus norvegicus	82-86
31781614-10	2019	Furthermore, naringin treatment decreased LOX-1, NADPH oxidase subunits (p47phox, Nox2, and Nox4), and iNOS as well as oxidative damage markers (3-nitrotyrosine (3-NT) and 4-hydroxynonenal (4-HNE)) expression in aortic tissues from hypercholesterolaemic rats.	naringin	13-21	NADPH oxidase 4	Rattus norvegicus	92-96
31781614-10	2019	Furthermore, naringin treatment decreased LOX-1, NADPH oxidase subunits (p47phox, Nox2, and Nox4), and iNOS as well as oxidative damage markers (3-nitrotyrosine (3-NT) and 4-hydroxynonenal (4-HNE)) expression in aortic tissues from hypercholesterolaemic rats.	naringin	13-21	nitric oxide synthase 2	Rattus norvegicus	103-107
31781614-11	2019	These results demonstrate that naringin treatment improves endothelium dysfunction in hypercholesterolaemic rats, at least partially by decreasing oxidative stress via downregulation of LOX-1 and NADPH oxidase.	naringin	31-39	oxidized low density lipoprotein receptor 1	Rattus norvegicus	186-191
31299593-10	2019	The hub-bottleneck genes of the protein networks including PTGS2, CALM2, NOS2, SLC6A3 and MAOB, MAOA, CREB1 could become potential drug targets and Paeoniflorin, Naringin, Glycyrrhizic acid may be candidate agents.	naringin	162-170	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	59-64
31376623-0	2019	Naringin mitigates myocardial strain and the inflammatory response in sepsis-induced myocardial dysfunction through regulation of PI3K/AKT/NF-kappaB pathway.	naringin	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	135-138
31376623-8	2019	Moreover, Nar significantly decreased the levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) and myocardial enzymes (CK, LDH, and AST) induced by LPS and attenuated the inflammation response.	naringin	10-13	tumor necrosis factor	Rattus norvegicus	80-89
31376623-8	2019	Moreover, Nar significantly decreased the levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) and myocardial enzymes (CK, LDH, and AST) induced by LPS and attenuated the inflammation response.	naringin	10-13	interleukin 1 alpha	Rattus norvegicus	91-99
31376623-8	2019	Moreover, Nar significantly decreased the levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) and myocardial enzymes (CK, LDH, and AST) induced by LPS and attenuated the inflammation response.	naringin	10-13	interleukin 6	Rattus norvegicus	105-109
31376623-9	2019	Finally, Nar also inhibited NF-kappaB nuclear translocation and the activity of iNOS in H9c2 cardiomyocytes by activating PI3K/AKT signaling pathway.	naringin	9-12	nitric oxide synthase 2	Rattus norvegicus	80-84
31376623-9	2019	Finally, Nar also inhibited NF-kappaB nuclear translocation and the activity of iNOS in H9c2 cardiomyocytes by activating PI3K/AKT signaling pathway.	naringin	9-12	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
31299593-10	2019	The hub-bottleneck genes of the protein networks including PTGS2, CALM2, NOS2, SLC6A3 and MAOB, MAOA, CREB1 could become potential drug targets and Paeoniflorin, Naringin, Glycyrrhizic acid may be candidate agents.	naringin	162-170	calmodulin 2	Rattus norvegicus	66-71
31299593-10	2019	The hub-bottleneck genes of the protein networks including PTGS2, CALM2, NOS2, SLC6A3 and MAOB, MAOA, CREB1 could become potential drug targets and Paeoniflorin, Naringin, Glycyrrhizic acid may be candidate agents.	naringin	162-170	nitric oxide synthase 2	Rattus norvegicus	73-77
31299593-10	2019	The hub-bottleneck genes of the protein networks including PTGS2, CALM2, NOS2, SLC6A3 and MAOB, MAOA, CREB1 could become potential drug targets and Paeoniflorin, Naringin, Glycyrrhizic acid may be candidate agents.	naringin	162-170	monoamine oxidase B	Rattus norvegicus	90-94
31299593-10	2019	The hub-bottleneck genes of the protein networks including PTGS2, CALM2, NOS2, SLC6A3 and MAOB, MAOA, CREB1 could become potential drug targets and Paeoniflorin, Naringin, Glycyrrhizic acid may be candidate agents.	naringin	162-170	monoamine oxidase A	Rattus norvegicus	96-100
32215265-7	2019	Also, the co-administration of NG (160 mg/kg) antagonized the effect of BPA on SDL and TL, attenuated oxidative damage by lowering malondialdehyde and nitrite concentrations and restored superoxide dismutase, catalase, and glutathione S-transferase activities.	naringin	31-33	catalase	Rattus norvegicus	209-217
31292874-4	2019	In the present study, the aim was to investigate the effect of NG against CYP-induced liver, brain, kidney, heart, and testis toxicities on some metabolic enzyme activities such as AChE, BChE, CA, alpha-Gly, and AR.	naringin	63-65	acetylcholinesterase	Rattus norvegicus	181-185
31292874-4	2019	In the present study, the aim was to investigate the effect of NG against CYP-induced liver, brain, kidney, heart, and testis toxicities on some metabolic enzyme activities such as AChE, BChE, CA, alpha-Gly, and AR.	naringin	63-65	butyrylcholinesterase	Rattus norvegicus	187-191
31292874-4	2019	In the present study, the aim was to investigate the effect of NG against CYP-induced liver, brain, kidney, heart, and testis toxicities on some metabolic enzyme activities such as AChE, BChE, CA, alpha-Gly, and AR.	naringin	63-65	aldo-keto reductase family 1 member B1	Rattus norvegicus	212-214
31259654-0	2019	Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation.	naringin	0-8	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	64-68
31259654-5	2019	In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction.	naringin	40-48	neurogenin 3	Rattus norvegicus	96-101
30543828-0	2019	Molecular binding response of naringin and naringenin to H46R mutant SOD1 protein in combating protein aggregation using density functional theory and discrete molecular dynamics.	naringin	30-38	superoxide dismutase 1	Homo sapiens	69-73
30543828-6	2019	Further, we described the interaction of two naturally occurring polyphenol compounds, naringin and naringenin with mutant SOD1 that is regarded to hinder the protein aggregation.	naringin	87-95	superoxide dismutase 1	Homo sapiens	123-127
30543828-7	2019	Subsequently, the use of quantum chemical and molecular mechanics calculations speculated that naringin had a strong binding affinity with mutant SOD1 and impeded the formation of toxic aggregates than that of naringenin.	naringin	95-103	superoxide dismutase 1	Homo sapiens	146-150
31304904-7	2019	In the cells pretreated with naringin, LPS stimulated the activation of microglia to produce IL-1beta and TNF-alpha in a dose-dependent manner.	naringin	29-37	interleukin 1 alpha	Mus musculus	93-101
31304904-7	2019	In the cells pretreated with naringin, LPS stimulated the activation of microglia to produce IL-1beta and TNF-alpha in a dose-dependent manner.	naringin	29-37	tumor necrosis factor	Mus musculus	106-115
31304904-8	2019	Naringin inhibited LPS-induced release of IL-1beta, to a certain extent.	naringin	0-8	interleukin 1 alpha	Mus musculus	42-50
31304904-11	2019	Naringin pretreatment of cells significantly inhibited the activation of p65/NF-kappaB in a concentration-dependent manner.	naringin	0-8	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	73-76
31304904-11	2019	Naringin pretreatment of cells significantly inhibited the activation of p65/NF-kappaB in a concentration-dependent manner.	naringin	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
31304904-12	2019	In BV2 microglia, naringin inhibits LPO-induced production of NO and inflammatory factors, through a mechanism involving inhibition of activation of the p65/NF-kappaB signaling pathway.	naringin	18-26	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	153-156
31304904-12	2019	In BV2 microglia, naringin inhibits LPO-induced production of NO and inflammatory factors, through a mechanism involving inhibition of activation of the p65/NF-kappaB signaling pathway.	naringin	18-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
31092862-4	2019	During the molecular modelling studies of some naturally occurring flavonoids such as quercetin, luteolin, myricetin, kaempferol, naringin, hesperidin, galangin, baicalein and epicatechin with human ERalpha (3ERT and 1GWR), we observed that most of the ligands bound to the active site pocket of both 3ERT and 1GWR.	naringin	130-138	estrogen receptor 1	Homo sapiens	199-206
30878453-11	2019	RESULTS: The results of in vitro study showed that Akt activated by naringin promoted osteogenesis and osteocyte proliferation; in addition, osteocyte apoptosis and osteoclastogenesis was inhibited by Akt activation and Bad suppression.	naringin	68-76	AKT serine/threonine kinase 1	Rattus norvegicus	51-54
30878453-11	2019	RESULTS: The results of in vitro study showed that Akt activated by naringin promoted osteogenesis and osteocyte proliferation; in addition, osteocyte apoptosis and osteoclastogenesis was inhibited by Akt activation and Bad suppression.	naringin	68-76	AKT serine/threonine kinase 1	Rattus norvegicus	201-204
30878453-13	2019	CONCLUSIONS: Therefore, we concluded that naringin is an effective compound for promoting bone repair and preventing bone loss in rats with GIONFH through Akt/Bad signal cascades.	naringin	42-50	AKT serine/threonine kinase 1	Rattus norvegicus	155-158
31049130-11	2019	The treatments of APAP-administered rats with the peel extract, naringin, and naringenin produced a significant decrease in the elevated serum AST, ALT, ALP, LDH, and GGT activities as well as total bilirubin and TNF-alpha levels while they induced a significant increase in the lowered serum albumin and IL-4 levels.	naringin	64-72	PDZ and LIM domain 3	Rattus norvegicus	153-156
31049130-11	2019	The treatments of APAP-administered rats with the peel extract, naringin, and naringenin produced a significant decrease in the elevated serum AST, ALT, ALP, LDH, and GGT activities as well as total bilirubin and TNF-alpha levels while they induced a significant increase in the lowered serum albumin and IL-4 levels.	naringin	64-72	tumor necrosis factor	Rattus norvegicus	213-222
31049130-11	2019	The treatments of APAP-administered rats with the peel extract, naringin, and naringenin produced a significant decrease in the elevated serum AST, ALT, ALP, LDH, and GGT activities as well as total bilirubin and TNF-alpha levels while they induced a significant increase in the lowered serum albumin and IL-4 levels.	naringin	64-72	interleukin 4	Rattus norvegicus	305-309
30399589-11	2019	However, naringin significantly decreased malondialdehyde and nitrite contents, and reduced brain acetylcholinesterase activity in mice brains in a significant manner relative to controls.	naringin	9-17	acetylcholinesterase	Mus musculus	98-118
30512238-0	2019	Naringin prevents ultraviolet-B radiation-induced oxidative damage and inflammation through activation of peroxisome proliferator-activated receptor gamma in mouse embryonic fibroblast (NIH-3T3) cells.	naringin	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	106-154
30512238-4	2019	Furthermore, naringin prevents UVB-induced mitogen-activated protein kinase families and nuclear factor-kappaB (NF-kappaB)-mediated activation of inflammatory factors, that is TNF-alpha, IL-6, IL-10, and COX-2 in NIH-3T3 cells.	naringin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-110
30512238-4	2019	Furthermore, naringin prevents UVB-induced mitogen-activated protein kinase families and nuclear factor-kappaB (NF-kappaB)-mediated activation of inflammatory factors, that is TNF-alpha, IL-6, IL-10, and COX-2 in NIH-3T3 cells.	naringin	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
30512238-4	2019	Furthermore, naringin prevents UVB-induced mitogen-activated protein kinase families and nuclear factor-kappaB (NF-kappaB)-mediated activation of inflammatory factors, that is TNF-alpha, IL-6, IL-10, and COX-2 in NIH-3T3 cells.	naringin	13-21	tumor necrosis factor	Mus musculus	176-185
30512238-4	2019	Furthermore, naringin prevents UVB-induced mitogen-activated protein kinase families and nuclear factor-kappaB (NF-kappaB)-mediated activation of inflammatory factors, that is TNF-alpha, IL-6, IL-10, and COX-2 in NIH-3T3 cells.	naringin	13-21	interleukin 6	Mus musculus	187-191
30512238-4	2019	Furthermore, naringin prevents UVB-induced mitogen-activated protein kinase families and nuclear factor-kappaB (NF-kappaB)-mediated activation of inflammatory factors, that is TNF-alpha, IL-6, IL-10, and COX-2 in NIH-3T3 cells.	naringin	13-21	interleukin 10	Mus musculus	193-198
30512238-4	2019	Furthermore, naringin prevents UVB-induced mitogen-activated protein kinase families and nuclear factor-kappaB (NF-kappaB)-mediated activation of inflammatory factors, that is TNF-alpha, IL-6, IL-10, and COX-2 in NIH-3T3 cells.	naringin	13-21	cytochrome c oxidase II, mitochondrial	Mus musculus	204-209
30512238-7	2019	Thus, naringin prevents UVB-mediated inflammation and oxidative damage in NIH-3T3 cells probably over controlling NF-kappaB expression and activation of PPARgamma.	naringin	6-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
30512238-7	2019	Thus, naringin prevents UVB-mediated inflammation and oxidative damage in NIH-3T3 cells probably over controlling NF-kappaB expression and activation of PPARgamma.	naringin	6-14	peroxisome proliferator activated receptor gamma	Mus musculus	153-162
30827104-4	2019	However, the addition of naringenin (Nar, 25 muM) and naringin (Nar-G, 25 muM) standards significantly reduced the incorporation efficiency of Bc by 23.8 and 26.4%, respectively ( p &lt; 0.05).	naringin	54-62	latexin	Homo sapiens	74-77
30877721-7	2019	Overall, our findings suggest an enhanced protective capacity of naringin pegylated nanoparticles against Abeta amyloid linked oxidative stress mediated neurodegeneration in primary rat neuronal and glial hippocampal cultures for a certain incubation period.	naringin	65-73	amyloid beta precursor protein	Rattus norvegicus	106-111
30505814-6	2018	The combination of naringin and paclitaxel treatments synergistically increased the cytotoxic effects of paclitaxel in androgen-independent DU145 and PC3 cells, as well as in androgen-sensitive LNCaP cells.	naringin	19-27	proprotein convertase subtilisin/kexin type 1	Homo sapiens	150-153
30580326-3	2018	Here, we show that naringin inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1), a transcriptional repressor of epithelial differentiation involved in tumor metastasis.	naringin	19-27	zinc finger E-box binding homeobox 1	Homo sapiens	128-164
30580326-3	2018	Here, we show that naringin inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1), a transcriptional repressor of epithelial differentiation involved in tumor metastasis.	naringin	19-27	zinc finger E-box binding homeobox 1	Homo sapiens	166-170
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	cyclin D1	Homo sapiens	58-67
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	matrix metallopeptidase 2	Homo sapiens	69-73
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	BCL2 apoptosis regulator	Homo sapiens	79-84
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	zinc finger E-box binding homeobox 1	Homo sapiens	121-125
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	cyclin D1	Homo sapiens	205-214
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	matrix metallopeptidase 2	Homo sapiens	216-220
30580326-5	2018	The effects of naringin, which included downregulation of Cyclin D1, MMP2, and bcl-2, where reproduced by siRNA-mediated Zeb1 silencing, whereas Zeb1 overexpression increased proliferation, migration, and Cyclin D1, MMP2, and bcl-2 levels.	naringin	15-23	BCL2 apoptosis regulator	Homo sapiens	226-231
30316072-0	2018	Naringin protects against perfluorooctane sulfonate-induced liver injury by modulating NRF2 and NF-kappaB in mice.	naringin	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
30316072-7	2018	In addition, Nar enhanced anti-apoptotic Bcl-2 expression, decreased pro-apoptotic Bax expression and inhibited caspase-3 activation in liver tissue in mice exposed to PFOS.	naringin	13-16	B cell leukemia/lymphoma 2	Mus musculus	41-46
30316072-7	2018	In addition, Nar enhanced anti-apoptotic Bcl-2 expression, decreased pro-apoptotic Bax expression and inhibited caspase-3 activation in liver tissue in mice exposed to PFOS.	naringin	13-16	BCL2-associated X protein	Mus musculus	83-86
30316072-7	2018	In addition, Nar enhanced anti-apoptotic Bcl-2 expression, decreased pro-apoptotic Bax expression and inhibited caspase-3 activation in liver tissue in mice exposed to PFOS.	naringin	13-16	caspase 3	Mus musculus	112-121
30100482-8	2018	The alpha-l-rhamnosidase could hydrolyze quercitrin, naringin and neohesperidin, hesperidin and rutin rhamnose-containing glycosides but could not hydrolyze ginsenoside Rg2 or saiko-saponin C.	naringin	53-61	CC77DRAFT_584500	Alternaria alternata	4-24
30501090-5	2018	Naringenin, a parent structure of naringin with the excellent binding score of -9.3 kcal/mol, was completely in conjunction with the active site of D2R, indicating that it is critical for the treatment of gastrointestinal dysfunction.	naringin	34-42	dopamine receptor D2	Homo sapiens	148-151
30284462-7	2018	Our results showed that naringin could reduce the incidence of oxidative stress-induced apoptosis in nucleus pulposus cells and promoted the expression of autophagy markers LC3-II/I and beclin-1.	naringin	24-32	beclin 1	Rattus norvegicus	186-194
30021366-0	2018	Naringin suppresses the growth and motility of hypertrophic scar fibroblasts by inhibiting the kinase activity of Akt.	naringin	0-8	AKT serine/threonine kinase 1	Homo sapiens	114-117
30197681-6	2018	Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels.	naringin	68-76	microRNA 126	Homo sapiens	15-22
30197681-6	2018	Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels.	naringin	106-114	microRNA 126	Homo sapiens	15-22
30197681-6	2018	Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels.	naringin	106-114	AKT serine/threonine kinase 1	Homo sapiens	162-165
30197681-6	2018	Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels.	naringin	106-114	mechanistic target of rapamycin kinase	Homo sapiens	166-170
30197681-6	2018	Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels.	naringin	106-114	vascular cell adhesion molecule 1	Homo sapiens	187-193
30197681-8	2018	In summary, naringin exhibits its anti-cancer effect by suppressing cell growth of small cell lung cancer cells through miR-126/VCAM-1 signaling pathway.	naringin	12-20	microRNA 126	Homo sapiens	120-127
30197681-8	2018	In summary, naringin exhibits its anti-cancer effect by suppressing cell growth of small cell lung cancer cells through miR-126/VCAM-1 signaling pathway.	naringin	12-20	vascular cell adhesion molecule 1	Homo sapiens	128-134
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	156-162
29957300-7	2018	Naringin provided protection against the environmental toxicant, acrolein, in mice lung via modulating MAPK, p53, and NF-kappaB signaling pathways and our data may provide significant implications considering the prevalence of acrolein.	naringin	0-8	transformation related protein 53, pseudogene	Mus musculus	109-112
30092639-5	2018	Moreover, naringin treatment significantly decreased plasma 8-isoprostane (an indicator of the oxidative stress) level, fat weight, liver weight, hepatic total cholesterol concentration, hepatic triglyceride concentration, plasma leptin level, plasma insulin content, plasma low-density lipoprotein cholesterol level, and plasma PCSK9 production concomitantly with down-regulated expression of SREBP-2, PCSK9, and SREBP-1, and up-regulated expression of p-AMPKalpha and LDLR.	naringin	10-18	leptin	Mus musculus	230-236
30092639-5	2018	Moreover, naringin treatment significantly decreased plasma 8-isoprostane (an indicator of the oxidative stress) level, fat weight, liver weight, hepatic total cholesterol concentration, hepatic triglyceride concentration, plasma leptin level, plasma insulin content, plasma low-density lipoprotein cholesterol level, and plasma PCSK9 production concomitantly with down-regulated expression of SREBP-2, PCSK9, and SREBP-1, and up-regulated expression of p-AMPKalpha and LDLR.	naringin	10-18	proprotein convertase subtilisin/kexin type 9	Mus musculus	329-334
30092639-5	2018	Moreover, naringin treatment significantly decreased plasma 8-isoprostane (an indicator of the oxidative stress) level, fat weight, liver weight, hepatic total cholesterol concentration, hepatic triglyceride concentration, plasma leptin level, plasma insulin content, plasma low-density lipoprotein cholesterol level, and plasma PCSK9 production concomitantly with down-regulated expression of SREBP-2, PCSK9, and SREBP-1, and up-regulated expression of p-AMPKalpha and LDLR.	naringin	10-18	sterol regulatory element binding factor 2	Mus musculus	394-401
30092639-5	2018	Moreover, naringin treatment significantly decreased plasma 8-isoprostane (an indicator of the oxidative stress) level, fat weight, liver weight, hepatic total cholesterol concentration, hepatic triglyceride concentration, plasma leptin level, plasma insulin content, plasma low-density lipoprotein cholesterol level, and plasma PCSK9 production concomitantly with down-regulated expression of SREBP-2, PCSK9, and SREBP-1, and up-regulated expression of p-AMPKalpha and LDLR.	naringin	10-18	proprotein convertase subtilisin/kexin type 9	Mus musculus	403-408
30092639-5	2018	Moreover, naringin treatment significantly decreased plasma 8-isoprostane (an indicator of the oxidative stress) level, fat weight, liver weight, hepatic total cholesterol concentration, hepatic triglyceride concentration, plasma leptin level, plasma insulin content, plasma low-density lipoprotein cholesterol level, and plasma PCSK9 production concomitantly with down-regulated expression of SREBP-2, PCSK9, and SREBP-1, and up-regulated expression of p-AMPKalpha and LDLR.	naringin	10-18	sterol regulatory element binding transcription factor 1	Mus musculus	414-421
30092639-5	2018	Moreover, naringin treatment significantly decreased plasma 8-isoprostane (an indicator of the oxidative stress) level, fat weight, liver weight, hepatic total cholesterol concentration, hepatic triglyceride concentration, plasma leptin level, plasma insulin content, plasma low-density lipoprotein cholesterol level, and plasma PCSK9 production concomitantly with down-regulated expression of SREBP-2, PCSK9, and SREBP-1, and up-regulated expression of p-AMPKalpha and LDLR.	naringin	10-18	low density lipoprotein receptor	Mus musculus	470-474
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	colony stimulating factor 1 (macrophage)	Mus musculus	157-162
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	interleukin 6	Mus musculus	170-174
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	tumor necrosis factor	Mus musculus	179-188
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	interleukin 6	Mus musculus	207-211
29580144-5	2018	Naringin attenuated the severity of colitis and colorectal adenomas through inhibiting myeloid-derived suppressor cells (MDSCs), pro-inflammatory mediators GM-CSF/M-CSF, IL-6 and TNF-alpha and the NF-kappaB/IL-6/STAT3 cascades in colorectal tissues.	naringin	0-8	signal transducer and activator of transcription 3	Mus musculus	212-217
29443426-0	2018	Comprehensive investigation into the interconversion of C-2 diastereomers of naringin.	naringin	77-85	complement C2	Homo sapiens	56-59
29635128-11	2018	Furthermore, naringin improved impaired intestinal permeability and inhibited the release of TNF-alpha and IL-6, while increased IL-10 level in CLP mice and lipopolysaccharide (LPS)-stimulated MODE-K cells in a dose-dependent manner.	naringin	13-21	tumor necrosis factor	Mus musculus	93-102
29635128-11	2018	Furthermore, naringin improved impaired intestinal permeability and inhibited the release of TNF-alpha and IL-6, while increased IL-10 level in CLP mice and lipopolysaccharide (LPS)-stimulated MODE-K cells in a dose-dependent manner.	naringin	13-21	interleukin 6	Mus musculus	107-111
29635128-11	2018	Furthermore, naringin improved impaired intestinal permeability and inhibited the release of TNF-alpha and IL-6, while increased IL-10 level in CLP mice and lipopolysaccharide (LPS)-stimulated MODE-K cells in a dose-dependent manner.	naringin	13-21	interleukin 10	Mus musculus	129-134
29928387-13	2018	Additionally, naringin reduced the expression of B-cell lymphoma (Bcl)-2, Bcl-extra large (Bcl-xL), cyclin D1, c-Myc and survivin, while it increased the expression of caspase-3 and caspase-7.	naringin	14-22	B cell leukemia/lymphoma 2	Mus musculus	49-72
29928387-13	2018	Additionally, naringin reduced the expression of B-cell lymphoma (Bcl)-2, Bcl-extra large (Bcl-xL), cyclin D1, c-Myc and survivin, while it increased the expression of caspase-3 and caspase-7.	naringin	14-22	BCL2-like 1	Mus musculus	91-97
29928387-13	2018	Additionally, naringin reduced the expression of B-cell lymphoma (Bcl)-2, Bcl-extra large (Bcl-xL), cyclin D1, c-Myc and survivin, while it increased the expression of caspase-3 and caspase-7.	naringin	14-22	cyclin D1	Mus musculus	100-109
29928387-13	2018	Additionally, naringin reduced the expression of B-cell lymphoma (Bcl)-2, Bcl-extra large (Bcl-xL), cyclin D1, c-Myc and survivin, while it increased the expression of caspase-3 and caspase-7.	naringin	14-22	baculoviral IAP repeat-containing 5	Mus musculus	121-129
29928387-13	2018	Additionally, naringin reduced the expression of B-cell lymphoma (Bcl)-2, Bcl-extra large (Bcl-xL), cyclin D1, c-Myc and survivin, while it increased the expression of caspase-3 and caspase-7.	naringin	14-22	caspase 3	Mus musculus	168-177
29928387-13	2018	Additionally, naringin reduced the expression of B-cell lymphoma (Bcl)-2, Bcl-extra large (Bcl-xL), cyclin D1, c-Myc and survivin, while it increased the expression of caspase-3 and caspase-7.	naringin	14-22	caspase 7	Mus musculus	182-191
29930336-7	2018	We found that naringin suppressed mitochondrial ROS production and mitochondrial dysfunction in cardiomyocytes exposed to fructose and consequently reduced cardiomyocyte hypertrophy by regulating AMPK-mTOR signaling axis.	naringin	14-22	mechanistic target of rapamycin kinase	Mus musculus	201-205
29635128-13	2018	CONCLUSION: Naringin improved sepsis-induced intestinal injury via RhoA/ROCK/NF-kappaB/MLCK/MLC signaling pathway in vivo and in vitro.	naringin	12-20	ras homolog family member A	Mus musculus	67-71
29635128-13	2018	CONCLUSION: Naringin improved sepsis-induced intestinal injury via RhoA/ROCK/NF-kappaB/MLCK/MLC signaling pathway in vivo and in vitro.	naringin	12-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-86
29635128-13	2018	CONCLUSION: Naringin improved sepsis-induced intestinal injury via RhoA/ROCK/NF-kappaB/MLCK/MLC signaling pathway in vivo and in vitro.	naringin	12-20	myosin light chain kinase 3	Mus musculus	87-91
29456667-8	2018	Treatment with naringin was able to significantly ameliorate the NF-kappaB-induced overexpression of P-gp (P&lt;0.05).	naringin	15-23	nuclear factor kappa B subunit 1	Homo sapiens	65-74
29257271-0	2018	Naringin protects against steroid-induced avascular necrosis of the femoral head through upregulation of PPARgamma and activation of the Notch signaling pathway.	naringin	0-8	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	105-114
29257271-3	2018	Treatment with naringin markedly protected against the steroid-induced decrease in serum osteocalcin levels, and the rate of osteonecrosis in a model of SANFH.	naringin	15-23	osteocalcin	Oryctolagus cuniculus	89-100
29257271-5	2018	It was observed that naringin markedly inhibited caspase-3 activity, increased runt-related transcription factor 2 and transcription factor sp7 mRNA expression, promoted alkaline phosphatase activity and upregulated collagen I, peroxisome proliferator-activated receptor (PPAR) gamma2, neurogenic locus notch homolog protein (Notch), beta-catenin and phosphorylated-Rac-alpha serine/threonine protein kinase protein expression in the SANFH rabbit.	naringin	21-29	transcription factor Sp7	Oryctolagus cuniculus	140-143
29257271-5	2018	It was observed that naringin markedly inhibited caspase-3 activity, increased runt-related transcription factor 2 and transcription factor sp7 mRNA expression, promoted alkaline phosphatase activity and upregulated collagen I, peroxisome proliferator-activated receptor (PPAR) gamma2, neurogenic locus notch homolog protein (Notch), beta-catenin and phosphorylated-Rac-alpha serine/threonine protein kinase protein expression in the SANFH rabbit.	naringin	21-29	LOC100125986	Oryctolagus cuniculus	334-346
29456667-8	2018	Treatment with naringin was able to significantly ameliorate the NF-kappaB-induced overexpression of P-gp (P&lt;0.05).	naringin	15-23	ATP binding cassette subfamily B member 1	Homo sapiens	101-105