PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25873348-1	2015	The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells.	indole-3-carbaldehyde	56-73	aryl-hydrocarbon receptor	Mus musculus	102-127
26332658-1	2015	An exceptional probe comprising indole-3-carboxaldehyde fluorescein hydrazone (FI) performs multiple tasks, namely, disaggregating amyloid beta (Abeta) aggregates in different biomarker environments such as cerebrospinal fluid (CSF), Abeta1-40 fibrils, beta-amyloid lysozyme aggregates (LA), and U87 MG human astrocyte cells.	indole-3-carbaldehyde	32-55	small nucleolar RNA, C/D box 87	Homo sapiens	296-299
25873348-1	2015	The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells.	indole-3-carbaldehyde	56-73	aryl-hydrocarbon receptor	Mus musculus	129-132
25873348-1	2015	The tryptophan microbiota metabolites indole-3-acetate, indole-3-aldehyde, indole, and tryptamine are aryl hydrocarbon receptor (AhR) ligands, and in this study we investigated their AhR agonist and antagonist activities in nontransformed young adult mouse colonocyte (YAMC) cells.	indole-3-carbaldehyde	56-73	aryl-hydrocarbon receptor	Mus musculus	183-186
23973224-3	2013	Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.	indole-3-carbaldehyde	203-220	aryl hydrocarbon receptor	Homo sapiens	191-194
24703409-2	2014	This assay system comprises of indole-3-carboxaldehyde functionalized fluorescein hydrazone (FI) assay which displays a typically high absorption at 492 and 620 nm in the presence of Cu2+ and also shows FRET induced fluorescence turn-on exclusively with Cu2+.	indole-3-carbaldehyde	31-54	immunoglobulin kappa variable 1-35	Mus musculus	183-186
24703409-2	2014	This assay system comprises of indole-3-carboxaldehyde functionalized fluorescein hydrazone (FI) assay which displays a typically high absorption at 492 and 620 nm in the presence of Cu2+ and also shows FRET induced fluorescence turn-on exclusively with Cu2+.	indole-3-carbaldehyde	31-54	immunoglobulin kappa variable 1-35	Mus musculus	254-257
23973224-3	2013	Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.	indole-3-carbaldehyde	203-220	aryl hydrocarbon receptor	Homo sapiens	164-189
23973224-3	2013	Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.	indole-3-carbaldehyde	203-220	aryl hydrocarbon receptor	Homo sapiens	241-244
23973224-3	2013	Switching from sugar to Trp as an energy source (e.g., under conditions of unrestricted Trp availability), highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.	indole-3-carbaldehyde	203-220	interleukin 22	Homo sapiens	255-259
9489015-3	1998	One of them (AO1) had a higher substrate preference for indole-3-aldehyde.	indole-3-carbaldehyde	56-73	amine oxidase 1	Arabidopsis thaliana	13-16
21631432-4	2011	Uniquely, when overexpressed in bacteria, family members GSTF2 and GSTF3 bound a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde.	indole-3-carbaldehyde	161-178	glutathione S-transferase PHI 2	Arabidopsis thaliana	57-62
21631432-4	2011	Uniquely, when overexpressed in bacteria, family members GSTF2 and GSTF3 bound a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde.	indole-3-carbaldehyde	161-178	glutathione S-transferase F3	Arabidopsis thaliana	67-72
16079130-8	2005	Several dietary plant micronutrients that inhibit carcinogenesis, including indole-3-carbinol, indole-3-carboxaldehyde, ferulic acid, vanillic acid, and epigallocatechin-3-gallate, were effective inhibitors of the activity of catalase oxidase.	indole-3-carbaldehyde	95-118	catalase	Bos taurus	226-234
34202407-3	2021	Here, we assess whether indole-3-aldehyde (3-IAld), a ligand of the aryl hydrocarbon receptor (AhR), may encompass such an activity.	indole-3-carbaldehyde	24-41	aryl-hydrocarbon receptor	Mus musculus	68-93
34906172-11	2021	Treatment with recombinant IL22 or indole-3-carboxaldehyde (I3A) prevented PM associated lung injury.	indole-3-carbaldehyde	60-63	interleukin 22	Mus musculus	27-31
34391857-1	2021	A tryptophan metabolite of microbial origin, indole-3-carboxaldehyde (3-IAld), has been recently identified as a Janus molecule that, acting at the host-pathogen interface and activating the aryl hydrocarbon receptor, can result as a potential candidate to treat infections as well as diseases with an inflammatory and/or immune component.	indole-3-carbaldehyde	45-68	aryl hydrocarbon receptor	Homo sapiens	191-216
34202407-3	2021	Here, we assess whether indole-3-aldehyde (3-IAld), a ligand of the aryl hydrocarbon receptor (AhR), may encompass such an activity.	indole-3-carbaldehyde	24-41	aryl-hydrocarbon receptor	Mus musculus	95-98
33865951-0	2021	Enteric formulated indole-3-carboxaldehyde targets the aryl hydrocarbon receptor for protection in a murine model of metabolic syndrome.	indole-3-carbaldehyde	19-42	aryl-hydrocarbon receptor	Mus musculus	55-80
35236743-6	2022	METHODS: To this purpose, we have tested indole-3-carboxaldehyde (3-IAld), a microbial tryptophan catabolite known to contribute to epithelial barrier function and immune homeostasis in the gut via the aryl hydrocarbon receptor (AhR), in different murine models of ICI-induced colitis.	indole-3-carbaldehyde	41-64	aryl-hydrocarbon receptor	Mus musculus	202-227
35236743-6	2022	METHODS: To this purpose, we have tested indole-3-carboxaldehyde (3-IAld), a microbial tryptophan catabolite known to contribute to epithelial barrier function and immune homeostasis in the gut via the aryl hydrocarbon receptor (AhR), in different murine models of ICI-induced colitis.	indole-3-carbaldehyde	41-64	aryl-hydrocarbon receptor	Mus musculus	229-232
33865951-2	2021	We have recently discovered a tryptophan metabolite of microbial origin, indole-3-carboxaldehyde (3-IAld), able to regulate intestinal mucosal homeostasis by acting as a ligand of AhR.	indole-3-carbaldehyde	73-96	aryl-hydrocarbon receptor	Mus musculus	180-183
33755912-0	2021	Indole-3-carboxaldehyde regulates RSV-induced inflammatory response in RAW264.7 cells by moderate inhibition of the TLR7 signaling pathway.	indole-3-carbaldehyde	0-23	toll-like receptor 7	Mus musculus	116-120
33755912-7	2021	Our results demonstrated that RSV-induced IFN-alpha excessive secretion was moderately inhibited by indole-3-carboxaldehyde through downregulation of mRNA expression in a dose-dependent manner, in comparison, the inhibitory effects of ribavirin were too strong.	indole-3-carbaldehyde	100-123	interferon alpha	Mus musculus	42-51
33755912-8	2021	Furthermore, we revealed that indole-3-carboxaldehyde suppressed transcription of IFN-alpha by inhibiting RSV-induced TLR7 expression in RAW264.7 cells.	indole-3-carbaldehyde	30-53	interferon alpha	Mus musculus	82-91
33755912-8	2021	Furthermore, we revealed that indole-3-carboxaldehyde suppressed transcription of IFN-alpha by inhibiting RSV-induced TLR7 expression in RAW264.7 cells.	indole-3-carbaldehyde	30-53	toll-like receptor 7	Mus musculus	118-122
33755912-9	2021	Additionally, indole-3-carboxaldehyde inhibited RSV-induced NF-kappaB signalling activation in a TLR7-MyD88-dependent manner.	indole-3-carbaldehyde	14-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-69
33755912-9	2021	Additionally, indole-3-carboxaldehyde inhibited RSV-induced NF-kappaB signalling activation in a TLR7-MyD88-dependent manner.	indole-3-carbaldehyde	14-37	toll-like receptor 7	Mus musculus	97-101
33755912-9	2021	Additionally, indole-3-carboxaldehyde inhibited RSV-induced NF-kappaB signalling activation in a TLR7-MyD88-dependent manner.	indole-3-carbaldehyde	14-37	myeloid differentiation primary response gene 88	Mus musculus	102-107
33755912-10	2021	Together, our findings suggest that indole-3-carboxaldehyde inhibited RSV-induced inflammatory injury by moderate regulation of TLR7 signaling pathway and did not significantly affect the viral clearance competence of the innate immune system.	indole-3-carbaldehyde	36-59	toll-like receptor 7	Mus musculus	128-132
32286421-6	2020	Further, methionine, isoleucine, tryptophan, xanthurenic acid, and indole-3-carboxaldehyde were negatively associated with C-reactive protein (CRP), but 5-hydroxyindole-3-acetic acid was positively associated with CRP.	indole-3-carbaldehyde	67-90	C-reactive protein	Homo sapiens	123-141
33082071-5	2020	METHODS: LCs derived from CD34+ hematopoietic stem cells in the cord blood were treated with a microbial metabolite of tryptophan, indole-3-aldehyde (IAId).	indole-3-carbaldehyde	131-148	CD34 molecule	Homo sapiens	26-30
32866000-4	2020	In this study, we constructed an IL4I1-overexpressed 293T cell line, and found that IL4I1 can catalyze Trp to produce indole-3-acetic acid (IAA) and indole-3-carboxaldehyde (IAld).	indole-3-carbaldehyde	149-172	interleukin 4 induced 1	Homo sapiens	33-38
32866000-4	2020	In this study, we constructed an IL4I1-overexpressed 293T cell line, and found that IL4I1 can catalyze Trp to produce indole-3-acetic acid (IAA) and indole-3-carboxaldehyde (IAld).	indole-3-carbaldehyde	149-172	interleukin 4 induced 1	Homo sapiens	84-89
32866000-4	2020	In this study, we constructed an IL4I1-overexpressed 293T cell line, and found that IL4I1 can catalyze Trp to produce indole-3-acetic acid (IAA) and indole-3-carboxaldehyde (IAld).	indole-3-carbaldehyde	174-178	interleukin 4 induced 1	Homo sapiens	33-38
32866000-4	2020	In this study, we constructed an IL4I1-overexpressed 293T cell line, and found that IL4I1 can catalyze Trp to produce indole-3-acetic acid (IAA) and indole-3-carboxaldehyde (IAld).	indole-3-carbaldehyde	174-178	interleukin 4 induced 1	Homo sapiens	84-89
33454521-3	2021	One such metabolite, indole-3-aldehyde (3-IAld), is produced by the gut microbiota and was originally identified for its ability to promote epithelial barrier functions by working as an agonist of the Aryl hydrocarbon Receptor.	indole-3-carbaldehyde	21-38	aryl hydrocarbon receptor	Homo sapiens	201-226
32232974-14	2020	Indole-3-carboxaldehyde is an agonist for the aryl hydrocarbon receptor and regulates the mucosal reactivity and inflammation.	indole-3-carbaldehyde	0-23	aryl hydrocarbon receptor	Homo sapiens	46-71
32286421-6	2020	Further, methionine, isoleucine, tryptophan, xanthurenic acid, and indole-3-carboxaldehyde were negatively associated with C-reactive protein (CRP), but 5-hydroxyindole-3-acetic acid was positively associated with CRP.	indole-3-carbaldehyde	67-90	C-reactive protein	Homo sapiens	143-146
32286421-8	2020	Long-term overweight from childhood into late adolescence is associated with decreased urinary levels of gut bacteria-derived indole-3-acetic acid, and several urinary amino acids, including gut bacteria-derived indole-3-carboxaldehyde are associated with elevated CRP later on in life.	indole-3-carbaldehyde	212-235	C-reactive protein	Homo sapiens	265-268
31681274-0	2019	Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk.	indole-3-carbaldehyde	45-62	interleukin 22	Homo sapiens	110-115
31681274-0	2019	Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk.	indole-3-carbaldehyde	45-62	interleukin 18	Homo sapiens	116-121
31681274-9	2019	Administration of the microbial metabolite indole-3-aldehyde, known to stimulate the production of IL-22 via the aryl hydrocarbon receptor (AhR), promoted IL-18 expression and protection against Candida infection.	indole-3-carbaldehyde	43-60	interleukin 22	Homo sapiens	99-104
31681274-9	2019	Administration of the microbial metabolite indole-3-aldehyde, known to stimulate the production of IL-22 via the aryl hydrocarbon receptor (AhR), promoted IL-18 expression and protection against Candida infection.	indole-3-carbaldehyde	43-60	aryl hydrocarbon receptor	Homo sapiens	140-143
31681274-9	2019	Administration of the microbial metabolite indole-3-aldehyde, known to stimulate the production of IL-22 via the aryl hydrocarbon receptor (AhR), promoted IL-18 expression and protection against Candida infection.	indole-3-carbaldehyde	43-60	interleukin 18	Homo sapiens	155-160
29670460-5	2018	A microbial trp metabolic pathway leading to the production of indole-3-aldehyde (3-IAld) by lactobacilli provided epithelial protection while inducing antifungal resistance via the AhR/IL-22 axis.	indole-3-carbaldehyde	63-80	aryl hydrocarbon receptor	Homo sapiens	182-185
30777439-2	2019	Resident microbiota are capable of influencing AHR-dependent signaling pathways via production of an array of bioactive molecules that act as AHR agonists, such as indole or indole-3-aldehyde.	indole-3-carbaldehyde	174-191	aryl hydrocarbon receptor	Homo sapiens	47-50
30777439-2	2019	Resident microbiota are capable of influencing AHR-dependent signaling pathways via production of an array of bioactive molecules that act as AHR agonists, such as indole or indole-3-aldehyde.	indole-3-carbaldehyde	174-191	aryl hydrocarbon receptor	Homo sapiens	142-145
30257880-6	2018	Transcriptional profiling and gene ontology analysis indicated that ICA administration upregulated genes associated with the type I interferon (IFN1) response, which has been shown to protect against radiation-induced intestinal damage and reduce subsequent GVHD pathology.	indole-3-carbaldehyde	68-71	IFN1@	Homo sapiens	144-148
30257880-7	2018	Accordingly, protective effects of ICA following radiation exposure were abrogated in mice lacking IFN1 signaling.	indole-3-carbaldehyde	35-38	IFN1@	Homo sapiens	99-103
29670460-5	2018	A microbial trp metabolic pathway leading to the production of indole-3-aldehyde (3-IAld) by lactobacilli provided epithelial protection while inducing antifungal resistance via the AhR/IL-22 axis.	indole-3-carbaldehyde	63-80	interleukin 22	Homo sapiens	186-191
28174680-5	2017	Complexes of the AtGSTF2 dimer were obtained with indole-3-aldehyde, camalexin, the flavonoid quercetrin and its non-rhamnosylated analogue quercetin, at resolutions of 2.00, 2.77, 2.25 and 2.38 A respectively.	indole-3-carbaldehyde	50-67	glutathione S-transferase PHI 2	Arabidopsis thaliana	17-24
28719347-0	2017	Regulatory effects of the novel synthesized Indole-3-carbaldehyde on expression of cell cycle genes: A study on Cyclin D and P21 expression by acute promylocytic leukemia cell line (NB4) This article has been withdrawn.	indole-3-carbaldehyde	44-65	proliferating cell nuclear antigen	Homo sapiens	112-118
28719347-0	2017	Regulatory effects of the novel synthesized Indole-3-carbaldehyde on expression of cell cycle genes: A study on Cyclin D and P21 expression by acute promylocytic leukemia cell line (NB4) This article has been withdrawn.	indole-3-carbaldehyde	44-65	H3 histone pseudogene 16	Homo sapiens	125-128