PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33039967-0	2020	Alpinetin prevents inflammatory responses in OVA-induced allergic asthma through modulating PI3K/AKT/NF-kappaB and HO-1 signaling pathways in mice.	alpinetin	0-9	thymoma viral proto-oncogene 1	Mus musculus	97-100
33743314-0	2021	Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-kappaB/MAPK signaling pathways.	alpinetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	89-98
33743314-11	2021	In vitro, we also observed that alpinetin inhibited the inflammatory response, apoptosis, and activation of the NF-kappaB/MAPK pathways in hepatocytes after H/R treatment.	alpinetin	32-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-121
33743314-13	2021	The protective effects of alpinetin on hepatic I/R injury may be due to its ability to inhibit the NF-kappaB/MAPK signaling pathways.	alpinetin	26-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
33039967-0	2020	Alpinetin prevents inflammatory responses in OVA-induced allergic asthma through modulating PI3K/AKT/NF-kappaB and HO-1 signaling pathways in mice.	alpinetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
33039967-0	2020	Alpinetin prevents inflammatory responses in OVA-induced allergic asthma through modulating PI3K/AKT/NF-kappaB and HO-1 signaling pathways in mice.	alpinetin	0-9	heme oxygenase 1	Mus musculus	115-119
33862553-0	2021	Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.	alpinetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
33862553-0	2021	Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon tetrachloride-induced liver fibrosis.	alpinetin	0-9	NLR family, pyrin domain containing 3	Mus musculus	130-135
33862553-5	2021	Alpinetin ameliorated the CCl4-induced liver injury and fibrosis in mice, as shown by decreased collagen deposition and the decreased expression of liver fibrosis marker proteins.	alpinetin	0-9	chemokine (C-C motif) ligand 4	Mus musculus	26-30
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	chemokine (C-C motif) ligand 4	Mus musculus	41-45
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	NLR family, pyrin domain containing 3	Mus musculus	68-73
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	steroid sulfatase	Mus musculus	75-78
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	caspase 1	Mus musculus	88-97
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	interleukin 1 alpha	Mus musculus	117-125
33862553-8	2021	Mechanistically, alpinetin inhibited the CCl4-induced expression of NLRP3, ASC, cleaved caspase-1, mature (cleaved-) IL-1beta, and IL-18 in livers of mice.	alpinetin	17-26	interleukin 18	Mus musculus	131-136
33862553-9	2021	Furthermore, alpinetin resulted in an increased in the nuclear expression and a decrease in the cytoplasmic expression of Nrf2, as well as increased protein expression of downstream target enzymes, GCLC, HO-1, NQO1, and GCLM, thus exerting the antioxidant effect.	alpinetin	13-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
33862553-9	2021	Furthermore, alpinetin resulted in an increased in the nuclear expression and a decrease in the cytoplasmic expression of Nrf2, as well as increased protein expression of downstream target enzymes, GCLC, HO-1, NQO1, and GCLM, thus exerting the antioxidant effect.	alpinetin	13-22	glutamate-cysteine ligase, catalytic subunit	Mus musculus	198-202
33862553-9	2021	Furthermore, alpinetin resulted in an increased in the nuclear expression and a decrease in the cytoplasmic expression of Nrf2, as well as increased protein expression of downstream target enzymes, GCLC, HO-1, NQO1, and GCLM, thus exerting the antioxidant effect.	alpinetin	13-22	heme oxygenase 1	Mus musculus	204-208
33862553-9	2021	Furthermore, alpinetin resulted in an increased in the nuclear expression and a decrease in the cytoplasmic expression of Nrf2, as well as increased protein expression of downstream target enzymes, GCLC, HO-1, NQO1, and GCLM, thus exerting the antioxidant effect.	alpinetin	13-22	NAD(P)H dehydrogenase, quinone 1	Mus musculus	210-214
33862553-9	2021	Furthermore, alpinetin resulted in an increased in the nuclear expression and a decrease in the cytoplasmic expression of Nrf2, as well as increased protein expression of downstream target enzymes, GCLC, HO-1, NQO1, and GCLM, thus exerting the antioxidant effect.	alpinetin	13-22	glutamate-cysteine ligase, modifier subunit	Mus musculus	220-224
33862553-10	2021	Overall, these findings suggested that the anti-fibrotic effect of alpinetin can be attributed to the inhibition of NLRP3-mediated anti-inflammatory activities and Nrf2-mediated anti-oxidative activities, in addition to the decrement of hepatic angiogenesis.	alpinetin	67-76	NLR family, pyrin domain containing 3	Mus musculus	116-121
33862553-10	2021	Overall, these findings suggested that the anti-fibrotic effect of alpinetin can be attributed to the inhibition of NLRP3-mediated anti-inflammatory activities and Nrf2-mediated anti-oxidative activities, in addition to the decrement of hepatic angiogenesis.	alpinetin	67-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	164-168
33039967-9	2020	Alpinetin also decreased the OVA-induced levels of IL-4, IL-5, IL-13 and IgE.	alpinetin	0-9	interleukin 4	Mus musculus	51-55
33039967-9	2020	Alpinetin also decreased the OVA-induced levels of IL-4, IL-5, IL-13 and IgE.	alpinetin	0-9	interleukin 5	Mus musculus	57-61
33039967-9	2020	Alpinetin also decreased the OVA-induced levels of IL-4, IL-5, IL-13 and IgE.	alpinetin	0-9	interleukin 13	Mus musculus	63-68
32474881-0	2020	Alpinetin Protects Chondrocytes and Exhibits Anti-Inflammatory Effects via the NF-kappaB/ERK Pathway for Alleviating Osteoarthritis.	alpinetin	0-9	Eph receptor B1	Rattus norvegicus	89-92
33039967-10	2020	Furthermore, alpinetin inhibited OVA-induced phosphorylation of p65, IkappaB, PI3K and AKT, and the activity of HO-1 in vivo.	alpinetin	13-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	64-67
33039967-10	2020	Furthermore, alpinetin inhibited OVA-induced phosphorylation of p65, IkappaB, PI3K and AKT, and the activity of HO-1 in vivo.	alpinetin	13-22	thymoma viral proto-oncogene 1	Mus musculus	87-90
33039967-10	2020	Furthermore, alpinetin inhibited OVA-induced phosphorylation of p65, IkappaB, PI3K and AKT, and the activity of HO-1 in vivo.	alpinetin	13-22	heme oxygenase 1	Mus musculus	112-116
33039967-12	2020	In conclusion, above results indicate that alpinetin exhibites a potent anti-inflammatory activity in allergic asthma through modulating PI3K/AKT/NF-kappaB and HO-1 signaling pathways, which would be used as a promising therapy agent for allergic asthma.	alpinetin	43-52	thymoma viral proto-oncogene 1	Mus musculus	142-145
33039967-12	2020	In conclusion, above results indicate that alpinetin exhibites a potent anti-inflammatory activity in allergic asthma through modulating PI3K/AKT/NF-kappaB and HO-1 signaling pathways, which would be used as a promising therapy agent for allergic asthma.	alpinetin	43-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155
33039967-12	2020	In conclusion, above results indicate that alpinetin exhibites a potent anti-inflammatory activity in allergic asthma through modulating PI3K/AKT/NF-kappaB and HO-1 signaling pathways, which would be used as a promising therapy agent for allergic asthma.	alpinetin	43-52	heme oxygenase 1	Mus musculus	160-164
33312544-7	2020	Additionally, protective affection of Alpinetin downregulated the IL-6 and upregulated the IL-10 (p < .01).	alpinetin	38-47	interleukin 6	Rattus norvegicus	66-70
33312544-7	2020	Additionally, protective affection of Alpinetin downregulated the IL-6 and upregulated the IL-10 (p < .01).	alpinetin	38-47	interleukin 10	Rattus norvegicus	91-96
32474881-13	2020	Graphical Abstract Inhibitory effects of Alpinetin on TNF-alpha-induced NF-kappaB activation resulted in destruction of cartilage in rat OA chondrocytes in vitro.	alpinetin	41-50	tumor necrosis factor	Rattus norvegicus	54-63
32474881-17	2020	However, Alpinetin could inhibits the NF-kappaB signaling pathway in different ways: APT inhibits IkappaBalpha phosphorylation, preventing phosphorylated ubiquitination of IkappaBalpha further.	alpinetin	9-18	NFKB inhibitor alpha	Rattus norvegicus	98-110
32474881-17	2020	However, Alpinetin could inhibits the NF-kappaB signaling pathway in different ways: APT inhibits IkappaBalpha phosphorylation, preventing phosphorylated ubiquitination of IkappaBalpha further.	alpinetin	9-18	NFKB inhibitor alpha	Rattus norvegicus	172-184
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	210-216
32372959-0	2020	Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease.	alpinetin	21-30	nuclear receptor subfamily 1 group I member 2	Homo sapiens	14-17
32372959-2	2020	We previously reported the identification of alpinetin as a ligand of human pregnane X receptor (hPXR).	alpinetin	45-54	nuclear receptor subfamily 1 group I member 2	Homo sapiens	76-95
32372959-2	2020	We previously reported the identification of alpinetin as a ligand of human pregnane X receptor (hPXR).	alpinetin	45-54	nuclear receptor subfamily 1 group I member 2	Homo sapiens	97-101
32372959-3	2020	The current study investigated the role of alpinetin as a putative PXR activator in ameliorating chemically induced inflammatory bowel disease (IBD).	alpinetin	43-52	nuclear receptor subfamily 1 group I member 2	Homo sapiens	67-70
32372959-4	2020	We found that oral administration of alpinetin significantly alleviated the severity of dextran sulfate sodium (DSS)-induced colitis in mice by decreasing the inflammatory infiltration, the levels of the pro-inflammatory mediators, and the PXR target genes in the colon.	alpinetin	37-46	nuclear receptor subfamily 1, group I, member 2	Mus musculus	240-243
32372959-6	2020	Further, alpinetin significantly upregulated PXR target genes and inhibited TNF-alpha-induced NF-kappaB-luciferase activity in LS174T colorectal cells; however, this regulatory effects were lost when cellular PXR gene was knocked down.	alpinetin	9-18	nuclear receptor subfamily 1 group I member 2	Homo sapiens	45-48
32372959-6	2020	Further, alpinetin significantly upregulated PXR target genes and inhibited TNF-alpha-induced NF-kappaB-luciferase activity in LS174T colorectal cells; however, this regulatory effects were lost when cellular PXR gene was knocked down.	alpinetin	9-18	tumor necrosis factor	Homo sapiens	76-85
32372959-6	2020	Further, alpinetin significantly upregulated PXR target genes and inhibited TNF-alpha-induced NF-kappaB-luciferase activity in LS174T colorectal cells; however, this regulatory effects were lost when cellular PXR gene was knocked down.	alpinetin	9-18	nuclear factor kappa B subunit 1	Homo sapiens	94-103
32372959-6	2020	Further, alpinetin significantly upregulated PXR target genes and inhibited TNF-alpha-induced NF-kappaB-luciferase activity in LS174T colorectal cells; however, this regulatory effects were lost when cellular PXR gene was knocked down.	alpinetin	9-18	nuclear receptor subfamily 1 group I member 2	Homo sapiens	209-212
32372959-7	2020	In PXR transactivation assays, alpinetin increased both mouse and human PXR transactivation in a dose-dependent manner.	alpinetin	31-40	nuclear receptor subfamily 1, group I, member 2	Mus musculus	3-6
32372959-7	2020	In PXR transactivation assays, alpinetin increased both mouse and human PXR transactivation in a dose-dependent manner.	alpinetin	31-40	nuclear receptor subfamily 1 group I member 2	Homo sapiens	72-75
32372959-8	2020	Ligand occluding mutants, S247W/C284W and S247W/C284W/S208W, in hPXR-reporter assays, abrogated alpinetin-induced hPXR transactivation.	alpinetin	96-105	nuclear receptor subfamily 1 group I member 2	Homo sapiens	64-68
32372959-8	2020	Ligand occluding mutants, S247W/C284W and S247W/C284W/S208W, in hPXR-reporter assays, abrogated alpinetin-induced hPXR transactivation.	alpinetin	96-105	nuclear receptor subfamily 1 group I member 2	Homo sapiens	114-118
32372959-9	2020	Finally, alpinetin bound to the hPXR-ligand-binding domain (LBD) was confirmed by competitive ligand binding assay.	alpinetin	9-18	nuclear receptor subfamily 1 group I member 2	Homo sapiens	32-36
31724331-0	2020	Inhibitory effect of alpinetin on IL-6 expression by promoting cytosine methylation in CpG islands in the IL-6 promoter region.	alpinetin	21-30	interleukin 6	Mus musculus	34-38
31724331-0	2020	Inhibitory effect of alpinetin on IL-6 expression by promoting cytosine methylation in CpG islands in the IL-6 promoter region.	alpinetin	21-30	interleukin 6	Mus musculus	106-110
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	77-86	interleukin 6	Mus musculus	139-152
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	77-86	interleukin 6	Mus musculus	154-158
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	77-86	interleukin 6	Mus musculus	231-235
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	77-86	interleukin 6	Mus musculus	231-235
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	319-328	interleukin 6	Mus musculus	154-158
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	319-328	interleukin 6	Mus musculus	231-235
31724331-2	2020	In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin-6 (IL-6), we detected the dinucleotide methylation status of CpG islands in the IL-6 promoter region and IL-6 level after treatment of RAW246.7 murine macrophages with alpinetin.	alpinetin	319-328	interleukin 6	Mus musculus	231-235
31724331-7	2020	RESULTS: Alpinetin promoted dinucleotide methylation status of two CpG islands in the IL-6 promoter region stretching 500-2500 bp upstream of the transcriptional start site (TSS) (p &lt; .05).	alpinetin	9-18	interleukin 6	Mus musculus	86-90
31724331-10	2020	PPAR antagonist GW9662 and interference of DNMT3A could reverse both the alpinetin-induced methylation and inhibitory effects on IL-6 expression.	alpinetin	73-82	peroxisome proliferator activated receptor alpha	Mus musculus	0-4
31724331-10	2020	PPAR antagonist GW9662 and interference of DNMT3A could reverse both the alpinetin-induced methylation and inhibitory effects on IL-6 expression.	alpinetin	73-82	DNA methyltransferase 3A	Mus musculus	43-49
31724331-11	2020	CONCLUSION: Alpinetin could induce dinucleotide methylation status of CpG islands in the IL-6 promoter region by activating methyltransferase, thus inhibiting IL-6 expression in murine macrophages.	alpinetin	12-21	interleukin 6	Mus musculus	89-93
31724331-11	2020	CONCLUSION: Alpinetin could induce dinucleotide methylation status of CpG islands in the IL-6 promoter region by activating methyltransferase, thus inhibiting IL-6 expression in murine macrophages.	alpinetin	12-21	interleukin 6	Mus musculus	159-163
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	264-271
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	308-314
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	316-322
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	324-330
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 2 member B15	Homo sapiens	335-342
29436891-9	2019	Inhibition of BCRP by its specific inhibitor Ko143 significantly reduced excretion of alpinetin glucuronide, leading to a significant decrease in cellular glucuronidation of alpinetin.	alpinetin	86-95	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	14-18
29436891-10	2019	Our data suggest UGTs and BCRP as two important determinants of alpinetin pharmacokinetics.	alpinetin	64-73	beta-1,3-glucuronyltransferase 2	Homo sapiens	17-21
29436891-10	2019	Our data suggest UGTs and BCRP as two important determinants of alpinetin pharmacokinetics.	alpinetin	64-73	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	26-30
31676321-0	2019	Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway.	alpinetin	0-9	aryl hydrocarbon receptor	Homo sapiens	65-68
31676321-0	2019	Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway.	alpinetin	0-9	SUV39H1 histone lysine methyltransferase	Homo sapiens	69-76
31676321-0	2019	Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway.	alpinetin	0-9	TSC complex subunit 2	Homo sapiens	77-81
31676321-0	2019	Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway.	alpinetin	0-9	CREB regulated transcription coactivator 1	Mus musculus	82-88
31676321-3	2019	Here, we showed that alpinetin significantly improved transepithelial electrical resistance (TEER) in TNF-alpha-stimulated Caco-2 cells, which was mainly mediated by inhibiting the apoptosis.	alpinetin	21-30	tumor necrosis factor	Homo sapiens	102-111
31676321-4	2019	Mechanistic studies demonstrated that alpinetin markedly increased the production of autophagosomes, along with obvious regulation of LC3B-II, beclin-1, p62, Atg7 and Atg5 expressions.	alpinetin	38-47	beclin 1	Homo sapiens	143-151
31676321-4	2019	Mechanistic studies demonstrated that alpinetin markedly increased the production of autophagosomes, along with obvious regulation of LC3B-II, beclin-1, p62, Atg7 and Atg5 expressions.	alpinetin	38-47	nucleoporin 62	Homo sapiens	153-156
31676321-4	2019	Mechanistic studies demonstrated that alpinetin markedly increased the production of autophagosomes, along with obvious regulation of LC3B-II, beclin-1, p62, Atg7 and Atg5 expressions.	alpinetin	38-47	autophagy related 7	Homo sapiens	158-162
31676321-4	2019	Mechanistic studies demonstrated that alpinetin markedly increased the production of autophagosomes, along with obvious regulation of LC3B-II, beclin-1, p62, Atg7 and Atg5 expressions.	alpinetin	38-47	autophagy related 5	Homo sapiens	167-171
31676321-7	2019	Additionally, alpinetin activated aryl hydrocarbon receptor (AhR) and promoted co-localization of AhR with suv39h1 in the cytoplasm.	alpinetin	14-23	aryl hydrocarbon receptor	Homo sapiens	34-59
31676321-7	2019	Additionally, alpinetin activated aryl hydrocarbon receptor (AhR) and promoted co-localization of AhR with suv39h1 in the cytoplasm.	alpinetin	14-23	aryl hydrocarbon receptor	Homo sapiens	61-64
31676321-7	2019	Additionally, alpinetin activated aryl hydrocarbon receptor (AhR) and promoted co-localization of AhR with suv39h1 in the cytoplasm.	alpinetin	14-23	aryl hydrocarbon receptor	Homo sapiens	98-101
31676321-7	2019	Additionally, alpinetin activated aryl hydrocarbon receptor (AhR) and promoted co-localization of AhR with suv39h1 in the cytoplasm.	alpinetin	14-23	SUV39H1 histone lysine methyltransferase	Homo sapiens	107-114
31676321-8	2019	The relationship between alpinetin-regulated AhR/suv39h1/TSC2/mTORC1 signals, autophagy and apoptosis of Caco-2 and NCM460 cells was confirmed by using CH223191, siAhR, siTSC2 and chloroquine.	alpinetin	25-34	aryl hydrocarbon receptor	Homo sapiens	45-48
31676321-8	2019	The relationship between alpinetin-regulated AhR/suv39h1/TSC2/mTORC1 signals, autophagy and apoptosis of Caco-2 and NCM460 cells was confirmed by using CH223191, siAhR, siTSC2 and chloroquine.	alpinetin	25-34	SUV39H1 histone lysine methyltransferase	Homo sapiens	49-56
31676321-8	2019	The relationship between alpinetin-regulated AhR/suv39h1/TSC2/mTORC1 signals, autophagy and apoptosis of Caco-2 and NCM460 cells was confirmed by using CH223191, siAhR, siTSC2 and chloroquine.	alpinetin	25-34	TSC complex subunit 2	Homo sapiens	57-61
31676321-8	2019	The relationship between alpinetin-regulated AhR/suv39h1/TSC2/mTORC1 signals, autophagy and apoptosis of Caco-2 and NCM460 cells was confirmed by using CH223191, siAhR, siTSC2 and chloroquine.	alpinetin	25-34	CREB regulated transcription coactivator 1	Mus musculus	62-68
29436891-3	2019	Glucuronidation potential of alpinetin was evaluated using pooled human liver microsomes (pHLM), pooled human intestine microsomes (pHIM) and expressed UGT enzymes supplemented with the cofactor UDPGA.	alpinetin	29-38	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	152-155
29436891-4	2019	Activity correlation analyses with a bank of individual HLMs were performed to identify the main contributing UGT isozymes in hepatic glucuronidation of alpinetin.	alpinetin	153-162	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	110-113
29436891-5	2019	The effect of BCRP on alpinetin disposition was assessed using HeLa cells overexpressing UGT1A1 (HeLa1A1) cells.	alpinetin	22-31	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	14-18
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	115-121
29436891-8	2019	Glucuronidation of alpinetin was significantly correlated with glucuronidation of estradiol (an activity marker of UGT1A1), chenodeoxycholic acid (an activity marker of UGT1A3), propofol (an activity marker of UGT1A9) and 5-hydroxyrofecoxib (an activity marker of UGT2B15), confirming the important roles of UGT1A1, UGT1A3, UGT1A9 and UGT2B15 in alpinetin glucuronidation.	alpinetin	19-28	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	169-175
29382419-0	2017	[Alpinetin promotes the binding of PPAR and methyltransferase].	alpinetin	1-10	peroxisome proliferator activated receptor alpha	Mus musculus	35-39
30166541-0	2018	Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.	alpinetin	0-9	aryl-hydrocarbon receptor	Mus musculus	53-56
30166541-0	2018	Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.	alpinetin	0-9	microRNA 302a	Mus musculus	69-76
30166541-0	2018	Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.	alpinetin	0-9	DNA methyltransferase (cytosine-5) 1	Mus musculus	77-83
30166541-0	2018	Alpinetin exerts anti-colitis efficacy by activating AhR, regulating miR-302/DNMT-1/CREB signals, and therefore promoting Treg differentiation.	alpinetin	0-9	cAMP responsive element binding protein 1	Mus musculus	84-88
30166541-6	2018	Furthermore, alpinetin significantly promoted expression of miR-302 but not others, and restrained expression of DNMT-1 and methylation level of Foxp3 promoter region in CD4+ T cells and colons of colitis mice.	alpinetin	13-22	microRNA 302a	Mus musculus	60-67
30166541-6	2018	Furthermore, alpinetin significantly promoted expression of miR-302 but not others, and restrained expression of DNMT-1 and methylation level of Foxp3 promoter region in CD4+ T cells and colons of colitis mice.	alpinetin	13-22	DNA methyltransferase (cytosine-5) 1	Mus musculus	113-119
30166541-6	2018	Furthermore, alpinetin significantly promoted expression of miR-302 but not others, and restrained expression of DNMT-1 and methylation level of Foxp3 promoter region in CD4+ T cells and colons of colitis mice.	alpinetin	13-22	forkhead box P3	Mus musculus	145-150
30166541-6	2018	Furthermore, alpinetin significantly promoted expression of miR-302 but not others, and restrained expression of DNMT-1 and methylation level of Foxp3 promoter region in CD4+ T cells and colons of colitis mice.	alpinetin	13-22	CD4 antigen	Mus musculus	170-173
30414839-6	2019	Alpinetin also inhibited liver myeloperoxidase (MPO) activity and malondialdehyde (MDA) level.	alpinetin	0-9	myeloperoxidase	Mus musculus	31-46
30414839-6	2019	Alpinetin also inhibited liver myeloperoxidase (MPO) activity and malondialdehyde (MDA) level.	alpinetin	0-9	myeloperoxidase	Mus musculus	48-51
30414839-8	2019	Alpinetin also attenuated LPS/D-Gal-induced expression of phospho-NF-kappaB p65 and phospho-IkappaBalpha.	alpinetin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	92-104
30414839-9	2019	In addition, alpinetin was found to increase the expression of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	alpinetin	13-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
30414839-9	2019	In addition, alpinetin was found to increase the expression of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1).	alpinetin	13-22	heme oxygenase 1	Mus musculus	109-125
30414839-10	2019	In conclusion, these findings suggested that alpinetin inhibited liver injury through inhibiting NF-kappaB and activating the Nrf2 signaling pathway.	alpinetin	45-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	126-130
30132572-11	2018	Alpinetin also inhibited cell migration, through increased protein expression levels of TIMP-1 and TIMP-2, and decreased protein expression levels of MMP-2 and MMP-9.	alpinetin	0-9	TIMP metallopeptidase inhibitor 1	Homo sapiens	88-94
30132572-11	2018	Alpinetin also inhibited cell migration, through increased protein expression levels of TIMP-1 and TIMP-2, and decreased protein expression levels of MMP-2 and MMP-9.	alpinetin	0-9	TIMP metallopeptidase inhibitor 2	Homo sapiens	99-105
30132572-11	2018	Alpinetin also inhibited cell migration, through increased protein expression levels of TIMP-1 and TIMP-2, and decreased protein expression levels of MMP-2 and MMP-9.	alpinetin	0-9	matrix metallopeptidase 2	Homo sapiens	150-155
30132572-11	2018	Alpinetin also inhibited cell migration, through increased protein expression levels of TIMP-1 and TIMP-2, and decreased protein expression levels of MMP-2 and MMP-9.	alpinetin	0-9	matrix metallopeptidase 9	Homo sapiens	160-165
30132572-14	2018	Overall, these results indicated that alpinetin may have anticancer effects on human ovarian cancer by inhibiting the STAT3 signaling pathway.	alpinetin	38-47	signal transducer and activator of transcription 3	Homo sapiens	118-123
30048861-5	2018	According to the results, alpinetin protected mice against LPS-induced endometritis by attenuating uterine histological changes and myeloperoxidase (MPO) activity.	alpinetin	26-35	myeloperoxidase	Mus musculus	132-147
30048861-5	2018	According to the results, alpinetin protected mice against LPS-induced endometritis by attenuating uterine histological changes and myeloperoxidase (MPO) activity.	alpinetin	26-35	myeloperoxidase	Mus musculus	149-152
30048861-9	2018	Taken together, the results of this study showed that alpinetin had protective effects against LPS-induced endometritis in mice, and the beneficial effects were occurred through the activation of PPAR-gamma and inhibition of the TLR4 signaling pathway.	alpinetin	54-63	peroxisome proliferator activated receptor gamma	Mus musculus	196-206
30048861-9	2018	Taken together, the results of this study showed that alpinetin had protective effects against LPS-induced endometritis in mice, and the beneficial effects were occurred through the activation of PPAR-gamma and inhibition of the TLR4 signaling pathway.	alpinetin	54-63	toll-like receptor 4	Mus musculus	229-233
29333130-3	2017	Here, curcumin, flavokawain B, and alpinetin were docked against the crystal structure of R273H mutant p53 in silico.	alpinetin	35-44	tumor protein p53	Homo sapiens	103-106
29333130-4	2017	Consequently, all the compounds bind to the cavity of R273H mutant p53 with a dissociation constant estimated to have 36.57, 70.77, and 75.11 microM for curcumin, flavokawain B, and alpinetin, respectively.	alpinetin	182-191	tumor protein p53	Homo sapiens	67-70
29382419-1	2017	Objective To screen the nucleus located-methyltransferase in murine macrophages (RAW246.7 cells) after peroxisome proliferator-activated receptors (PPAR) is activated by alpinetin so as to prove the epigenetic modification effect of alpinetin.	alpinetin	170-179	peroxisome proliferator activated receptor alpha	Mus musculus	103-146
29382419-1	2017	Objective To screen the nucleus located-methyltransferase in murine macrophages (RAW246.7 cells) after peroxisome proliferator-activated receptors (PPAR) is activated by alpinetin so as to prove the epigenetic modification effect of alpinetin.	alpinetin	170-179	peroxisome proliferator activated receptor alpha	Mus musculus	148-152
29382419-8	2017	Furthermore, only by a high concentration of alpinetin (1 000 mug/mL), could the synthesis of TDG mRNA be promoted, yet the synthesis of DNMT3alpha and EZH2 were not influenced.	alpinetin	45-54	thymine DNA glycosylase	Mus musculus	94-97
29382419-9	2017	Conclusion Alpinetin, the PPAR activator, could promote the synthesis and interaction of specific methyltransferases with PPAR in the nucleus, which indicates that methylation modification on histone or cytosine may be the interpretation for the effect of gene expression regulation caused by alpinetin.	alpinetin	11-20	peroxisome proliferator activated receptor alpha	Mus musculus	26-30
29382419-9	2017	Conclusion Alpinetin, the PPAR activator, could promote the synthesis and interaction of specific methyltransferases with PPAR in the nucleus, which indicates that methylation modification on histone or cytosine may be the interpretation for the effect of gene expression regulation caused by alpinetin.	alpinetin	11-20	peroxisome proliferator activated receptor alpha	Mus musculus	122-126
28103302-0	2017	Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells.	alpinetin	34-43	uridine-cytidine kinase 2	Homo sapiens	111-115
27321991-7	2016	The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-alpha) and interleukin (IL-1beta) production in mice.	alpinetin	24-33	myeloperoxidase	Mus musculus	110-125
27321991-7	2016	The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-alpha) and interleukin (IL-1beta) production in mice.	alpinetin	24-33	myeloperoxidase	Mus musculus	127-130
27321991-7	2016	The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-alpha) and interleukin (IL-1beta) production in mice.	alpinetin	24-33	tumor necrosis factor	Mus musculus	164-185
27321991-7	2016	The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-alpha) and interleukin (IL-1beta) production in mice.	alpinetin	24-33	tumor necrosis factor	Mus musculus	187-196
27321991-7	2016	The results showed that alpinetin significantly attenuated diarrhea, colonic shortening, histological injury, myeloperoxidase (MPO) activity and the expressions of tumor necrosis factor (TNF-alpha) and interleukin (IL-1beta) production in mice.	alpinetin	24-33	interleukin 1 beta	Mus musculus	215-223
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	tumor necrosis factor	Mus musculus	51-60
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	interleukin 1 beta	Mus musculus	65-73
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	NLR family, pyrin domain containing 3	Mus musculus	186-213
27321991-8	2016	In vitro, alpinetin markedly inhibited LPS-induced TNF-alpha and IL-1beta production, as well as Toll-like receptor 4 (TLR4) mediated nuclear transcription factor-kappaB (NF-kappaB) and NOD-like receptor protein 3 (NLRP3) inflammasome activation.	alpinetin	10-19	NLR family, pyrin domain containing 3	Mus musculus	215-220
26604699-4	2015	RESULTS: This study showed that the alpinetin inhibited the cell proliferation, enhanced the apoptosis, and inhibited the PI3K/Akt signaling in lung cancer cells.	alpinetin	36-45	AKT serine/threonine kinase 1	Homo sapiens	127-130
26604699-6	2015	Taken together, this study demonstrated that alpinetin significantly suppressed the development of human lung cancer possibly by influencing mitochondria and the PI3K/Akt signaling pathway and sensitized drug-resistant lung cancer cells.	alpinetin	45-54	AKT serine/threonine kinase 1	Homo sapiens	167-170
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	213-222	peroxisome proliferator activated receptor gamma	Homo sapiens	44-54
25496323-2	2015	Here, we investigated the effect of alpinetin on cholesterol efflux and lipid accumulation in oxidized low-density lipoprotein (ox-LDL)-treated THP-1 macrophages and human peripheral blood monocyte-derived macrophages (HMDMs).	alpinetin	36-45	GLI family zinc finger 2	Homo sapiens	144-149
25496323-3	2015	After exposing THP-1 macrophages to alpinetin, cholesterol efflux was determined by liquid scintillator.	alpinetin	36-45	GLI family zinc finger 2	Homo sapiens	15-20
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	213-222	nuclear receptor subfamily 1 group H member 3	Homo sapiens	58-67
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	94-103	peroxisome proliferator activated receptor gamma	Homo sapiens	44-54
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	94-103	nuclear receptor subfamily 1 group H member 3	Homo sapiens	58-67
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	94-103	GLI family zinc finger 2	Homo sapiens	136-141
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	94-103	peroxisome proliferator activated receptor gamma	Homo sapiens	185-195
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	94-103	nuclear receptor subfamily 1 group H member 3	Homo sapiens	200-209
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	213-222	GLI family zinc finger 2	Homo sapiens	136-141
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	213-222	peroxisome proliferator activated receptor gamma	Homo sapiens	185-195
25496323-6	2015	Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux.	alpinetin	213-222	nuclear receptor subfamily 1 group H member 3	Homo sapiens	200-209
25496323-7	2015	Alpinetin inhibited ox-LDL-induced lipid accumulation and enhanced the expression of ABCA1 and ABCG1 mRNA and protein, which was reversed by specific knockdown of PPAR-gamma or LXR-alpha.	alpinetin	0-9	ATP binding cassette subfamily A member 1	Homo sapiens	85-90
25496323-7	2015	Alpinetin inhibited ox-LDL-induced lipid accumulation and enhanced the expression of ABCA1 and ABCG1 mRNA and protein, which was reversed by specific knockdown of PPAR-gamma or LXR-alpha.	alpinetin	0-9	ATP binding cassette subfamily G member 1	Homo sapiens	95-100
25496323-7	2015	Alpinetin inhibited ox-LDL-induced lipid accumulation and enhanced the expression of ABCA1 and ABCG1 mRNA and protein, which was reversed by specific knockdown of PPAR-gamma or LXR-alpha.	alpinetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	163-173
25496323-7	2015	Alpinetin inhibited ox-LDL-induced lipid accumulation and enhanced the expression of ABCA1 and ABCG1 mRNA and protein, which was reversed by specific knockdown of PPAR-gamma or LXR-alpha.	alpinetin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	177-186
25496323-8	2015	Taken together, our results reveal that alpinetin exhibits positive effects on cholesterol efflux and inhibits ox-LDL-induced lipid accumulation, which might be through PPAR-gamma/LXR-alpha/ABCA1/ABCG1 pathway.	alpinetin	40-49	peroxisome proliferator activated receptor gamma	Homo sapiens	169-179
25496323-8	2015	Taken together, our results reveal that alpinetin exhibits positive effects on cholesterol efflux and inhibits ox-LDL-induced lipid accumulation, which might be through PPAR-gamma/LXR-alpha/ABCA1/ABCG1 pathway.	alpinetin	40-49	nuclear receptor subfamily 1 group H member 3	Homo sapiens	180-189
25496323-8	2015	Taken together, our results reveal that alpinetin exhibits positive effects on cholesterol efflux and inhibits ox-LDL-induced lipid accumulation, which might be through PPAR-gamma/LXR-alpha/ABCA1/ABCG1 pathway.	alpinetin	40-49	ATP binding cassette subfamily A member 1	Homo sapiens	190-195
25496323-8	2015	Taken together, our results reveal that alpinetin exhibits positive effects on cholesterol efflux and inhibits ox-LDL-induced lipid accumulation, which might be through PPAR-gamma/LXR-alpha/ABCA1/ABCG1 pathway.	alpinetin	40-49	ATP binding cassette subfamily G member 1	Homo sapiens	196-201
26321118-5	2015	Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production in kidney tissues.	alpinetin	0-9	tumor necrosis factor	Mus musculus	74-83
26321118-5	2015	Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production in kidney tissues.	alpinetin	0-9	interleukin 6	Mus musculus	85-89
26321118-5	2015	Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-alpha, IL-6 and IL-1beta production in kidney tissues.	alpinetin	0-9	interleukin 1 beta	Mus musculus	94-102
26321118-7	2015	In addition, alpinetin was found to up-regulate the expression of Nrf2 and HO-1 in a dose-dependent manner.	alpinetin	13-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
26321118-7	2015	In addition, alpinetin was found to up-regulate the expression of Nrf2 and HO-1 in a dose-dependent manner.	alpinetin	13-22	heme oxygenase 1	Mus musculus	75-79
26321118-8	2015	In conclusion, alpinetin protected LPS-induced kidney injury through activating Nrf2 and inhibiting TLR4 expression.	alpinetin	15-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	80-84
26321118-8	2015	In conclusion, alpinetin protected LPS-induced kidney injury through activating Nrf2 and inhibiting TLR4 expression.	alpinetin	15-24	toll-like receptor 4	Mus musculus	100-104
24964870-3	2014	The data showed that alpinetin markedly suppressed ConA-induced murine splenocyte proliferation, Th1/Th2 cytokines production, CD4(+) T-cell populations and ratio of CD4(+)/CD8(+).	alpinetin	21-30	negative elongation factor complex member C/D, Th1l	Mus musculus	97-100
24964870-3	2014	The data showed that alpinetin markedly suppressed ConA-induced murine splenocyte proliferation, Th1/Th2 cytokines production, CD4(+) T-cell populations and ratio of CD4(+)/CD8(+).	alpinetin	21-30	heart and neural crest derivatives expressed 2	Mus musculus	101-104
24964870-3	2014	The data showed that alpinetin markedly suppressed ConA-induced murine splenocyte proliferation, Th1/Th2 cytokines production, CD4(+) T-cell populations and ratio of CD4(+)/CD8(+).	alpinetin	21-30	CD4 antigen	Mus musculus	127-130
24964870-3	2014	The data showed that alpinetin markedly suppressed ConA-induced murine splenocyte proliferation, Th1/Th2 cytokines production, CD4(+) T-cell populations and ratio of CD4(+)/CD8(+).	alpinetin	21-30	CD4 antigen	Mus musculus	166-169
24964870-7	2014	The data revealed that alpinetin could shock the activation of NF-kappaB, NFAT2 signal transduction pathways.	alpinetin	23-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
24964870-7	2014	The data revealed that alpinetin could shock the activation of NF-kappaB, NFAT2 signal transduction pathways.	alpinetin	23-32	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	74-79
24104193-0	2013	Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-gamma in THP-1-derived macrophages.	alpinetin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	76-86
24348774-10	2014	In addition, it was shown that alpinetin was able to maintain the stability of the mitochondrial membrane potential, lower the level of intracytoplasmic cytochrome c and reduce Bax displacement from the cytoplasm to the mitochondria.	alpinetin	31-40	BCL2 associated X, apoptosis regulator	Rattus norvegicus	177-180
24348774-11	2014	It was concluded that alpinetin was able to activate delta receptors to induce the endogenous protection of myocardial cells via the PKC/ERK signaling pathway.	alpinetin	22-31	Eph receptor B1	Rattus norvegicus	137-140
24104193-0	2013	Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-gamma in THP-1-derived macrophages.	alpinetin	0-9	GLI family zinc finger 2	Homo sapiens	90-95
24104193-7	2013	The results showed that alpinetin inhibited TNF-alpha, IL-6 and IL-1beta expression in LPS-stimulated human THP-1 macrophages in a dose-dependent manner.	alpinetin	24-33	tumor necrosis factor	Homo sapiens	44-53
24104193-7	2013	The results showed that alpinetin inhibited TNF-alpha, IL-6 and IL-1beta expression in LPS-stimulated human THP-1 macrophages in a dose-dependent manner.	alpinetin	24-33	interleukin 6	Homo sapiens	55-59
24104193-7	2013	The results showed that alpinetin inhibited TNF-alpha, IL-6 and IL-1beta expression in LPS-stimulated human THP-1 macrophages in a dose-dependent manner.	alpinetin	24-33	interleukin 1 beta	Homo sapiens	64-72
24104193-7	2013	The results showed that alpinetin inhibited TNF-alpha, IL-6 and IL-1beta expression in LPS-stimulated human THP-1 macrophages in a dose-dependent manner.	alpinetin	24-33	GLI family zinc finger 2	Homo sapiens	108-113
24104193-8	2013	Western blot analysis showed that alpinetin suppressed LPS-induced NF-kappaB activation, IkappaBalpha degradation, phosphorylation of ERK, JNK and P38.	alpinetin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	67-76
24104193-8	2013	Western blot analysis showed that alpinetin suppressed LPS-induced NF-kappaB activation, IkappaBalpha degradation, phosphorylation of ERK, JNK and P38.	alpinetin	34-43	NFKB inhibitor alpha	Homo sapiens	89-101
24104193-8	2013	Western blot analysis showed that alpinetin suppressed LPS-induced NF-kappaB activation, IkappaBalpha degradation, phosphorylation of ERK, JNK and P38.	alpinetin	34-43	mitogen-activated protein kinase 1	Homo sapiens	134-137
24104193-8	2013	Western blot analysis showed that alpinetin suppressed LPS-induced NF-kappaB activation, IkappaBalpha degradation, phosphorylation of ERK, JNK and P38.	alpinetin	34-43	mitogen-activated protein kinase 8	Homo sapiens	139-142
24104193-8	2013	Western blot analysis showed that alpinetin suppressed LPS-induced NF-kappaB activation, IkappaBalpha degradation, phosphorylation of ERK, JNK and P38.	alpinetin	34-43	mitogen-activated protein kinase 1	Homo sapiens	147-150
24104193-10	2013	We also found that alpinetin could activate PPAR-gamma and the anti-inflammatory effects of alpinetin can be reversed by GW9662, a specific antagonist for PPAR-gamma.	alpinetin	19-28	peroxisome proliferator activated receptor gamma	Homo sapiens	44-54
24104193-10	2013	We also found that alpinetin could activate PPAR-gamma and the anti-inflammatory effects of alpinetin can be reversed by GW9662, a specific antagonist for PPAR-gamma.	alpinetin	19-28	peroxisome proliferator activated receptor gamma	Homo sapiens	155-165
24104193-10	2013	We also found that alpinetin could activate PPAR-gamma and the anti-inflammatory effects of alpinetin can be reversed by GW9662, a specific antagonist for PPAR-gamma.	alpinetin	92-101	peroxisome proliferator activated receptor gamma	Homo sapiens	155-165
24104193-11	2013	These results suggest that alpinetin activates PPAR-gamma, thereby attenuating TLR4 expression and TLR4 mediated NF-kappaB and MAPK activation and the release of pro-inflammatory cytokines.	alpinetin	27-36	peroxisome proliferator activated receptor gamma	Homo sapiens	47-57
24104193-11	2013	These results suggest that alpinetin activates PPAR-gamma, thereby attenuating TLR4 expression and TLR4 mediated NF-kappaB and MAPK activation and the release of pro-inflammatory cytokines.	alpinetin	27-36	toll like receptor 4	Homo sapiens	79-83
24104193-11	2013	These results suggest that alpinetin activates PPAR-gamma, thereby attenuating TLR4 expression and TLR4 mediated NF-kappaB and MAPK activation and the release of pro-inflammatory cytokines.	alpinetin	27-36	toll like receptor 4	Homo sapiens	99-103
24104193-11	2013	These results suggest that alpinetin activates PPAR-gamma, thereby attenuating TLR4 expression and TLR4 mediated NF-kappaB and MAPK activation and the release of pro-inflammatory cytokines.	alpinetin	27-36	nuclear factor kappa B subunit 1	Homo sapiens	113-122
24104193-11	2013	These results suggest that alpinetin activates PPAR-gamma, thereby attenuating TLR4 expression and TLR4 mediated NF-kappaB and MAPK activation and the release of pro-inflammatory cytokines.	alpinetin	27-36	mitogen-activated protein kinase 1	Homo sapiens	127-131
23254270-5	2013	The aim of the current study was to investigate             the roles of Bax and the mitochondrial pathway during alpinetin-induced gastric             cancer cell apoptosis and the effects of alpinetin on the cell cycle.	alpinetin	114-123	BCL2 associated X, apoptosis regulator	Homo sapiens	73-76
23669335-6	2013	In vitro, we also observed that alpinetin inhibited the expression of TLR4 and the production of TNF-alpha, IL-1beta and IL-6 in LPS-stimulated primary mouse mammary epithelial cells.	alpinetin	32-41	toll-like receptor 4	Mus musculus	70-74
23669335-6	2013	In vitro, we also observed that alpinetin inhibited the expression of TLR4 and the production of TNF-alpha, IL-1beta and IL-6 in LPS-stimulated primary mouse mammary epithelial cells.	alpinetin	32-41	tumor necrosis factor	Mus musculus	97-106
23669335-6	2013	In vitro, we also observed that alpinetin inhibited the expression of TLR4 and the production of TNF-alpha, IL-1beta and IL-6 in LPS-stimulated primary mouse mammary epithelial cells.	alpinetin	32-41	interleukin 1 beta	Mus musculus	108-116
23669335-6	2013	In vitro, we also observed that alpinetin inhibited the expression of TLR4 and the production of TNF-alpha, IL-1beta and IL-6 in LPS-stimulated primary mouse mammary epithelial cells.	alpinetin	32-41	interleukin 6	Mus musculus	121-125
23669335-8	2013	In conclusion, our results suggest that the anti-inflammatory effects of alpinetin against LPS-induced mastitis may be due to its ability to inhibit TLR4-mediated NF-kappaB signaling pathways.	alpinetin	73-82	toll-like receptor 4	Mus musculus	149-153
23254270-8	2013	During the early stages of apoptosis, alpinetin may alter             mitochondrial membrane potential leading to release of cytochrome c from mitochondria,             activation of caspase family members and ultimately apoptosis of human gastric             cancer cells.	alpinetin	38-47	cytochrome c, somatic	Homo sapiens	125-137
22246103-8	2012	Furthermore, alpinetin             treatment led to the release of cytochrome c and activation of caspases-3, -8             and -9 proteins.	alpinetin	13-22	cytochrome c, somatic	Homo sapiens	67-79
22246103-8	2012	Furthermore, alpinetin             treatment led to the release of cytochrome c and activation of caspases-3, -8             and -9 proteins.	alpinetin	13-22	caspase 3	Homo sapiens	98-131
22246103-9	2012	Taken together, our studies indicate that alpinetin inhibited             the proliferation of pancreatic cancer cells possibly through the regulation of             the Bcl-2 family and XIAP expression, release of cytochrome c and the activation             of caspases.	alpinetin	42-51	BCL2 apoptosis regulator	Homo sapiens	170-175
22246103-9	2012	Taken together, our studies indicate that alpinetin inhibited             the proliferation of pancreatic cancer cells possibly through the regulation of             the Bcl-2 family and XIAP expression, release of cytochrome c and the activation             of caspases.	alpinetin	42-51	X-linked inhibitor of apoptosis	Homo sapiens	187-191
22246103-9	2012	Taken together, our studies indicate that alpinetin inhibited             the proliferation of pancreatic cancer cells possibly through the regulation of             the Bcl-2 family and XIAP expression, release of cytochrome c and the activation             of caspases.	alpinetin	42-51	cytochrome c, somatic	Homo sapiens	215-227
22246103-9	2012	Taken together, our studies indicate that alpinetin inhibited             the proliferation of pancreatic cancer cells possibly through the regulation of             the Bcl-2 family and XIAP expression, release of cytochrome c and the activation             of caspases.	alpinetin	42-51	caspase 8	Homo sapiens	262-270
22159816-0	2012	Alpinetin suppresses proliferation of human hepatoma cells by the activation             of MKK7 and elevates sensitization to cis-diammined dichloridoplatium.	alpinetin	0-9	mitogen-activated protein kinase kinase 7	Homo sapiens	92-96
22159816-8	2012	The results showed that alpinetin suppressed HepG2 cell proliferation and arrested cells in the G0/G1 phase by up-regulating the expression levels of p-MKK7.	alpinetin	24-33	mitogen-activated protein kinase kinase 7	Homo sapiens	152-156
18619327-1	2008	The interaction between alpinetin and human serum albumin (HSA) was studied by fluorescence and UV/Vis absorption spectroscopy.	alpinetin	24-33	albumin	Homo sapiens	44-57
20427226-0	2010	Interaction of alpinetin with bovine serum albumin: Probing of the mechanism and binding site by spectroscopic methods.	alpinetin	15-24	albumin	Homo sapiens	37-50
20427226-1	2010	The binding interaction between alpinetin and bovine serum albumin (BSA) in physiological buffer solution (pH 7.4) was investigated by fluorescence, UV-vis spectroscopy and Fourier transform infrared (FT-IR) spectroscopy.	alpinetin	32-41	albumin	Homo sapiens	53-66
22178196-4	2012	The results showed that alpinetin markedly inhibited the LPS- induced TNF-alpha, IL-6 and IL-1beta production both in vitro and vivo.	alpinetin	24-33	tumor necrosis factor	Mus musculus	70-79
22178196-4	2012	The results showed that alpinetin markedly inhibited the LPS- induced TNF-alpha, IL-6 and IL-1beta production both in vitro and vivo.	alpinetin	24-33	interleukin 6	Mus musculus	81-85
22178196-4	2012	The results showed that alpinetin markedly inhibited the LPS- induced TNF-alpha, IL-6 and IL-1beta production both in vitro and vivo.	alpinetin	24-33	interleukin 1 beta	Mus musculus	90-98
35332570-0	2022	Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3beta/Fyn-dependent Nrf2 activation.	alpinetin	0-9	glycogen synthase kinase 3 alpha	Mus musculus	114-122
34093209-0	2021	Preclinical Investigation of Alpinetin in the Treatment of Cancer-Induced Cachexia via Activating PPARgamma.	alpinetin	29-38	peroxisome proliferator activated receptor gamma	Homo sapiens	98-107
15008454-5	2004	It was also found that alpinetin (10(-7)-10(-9) mol L(-1)) could significantly inhibit the production of NO in cultured VSMC induced by TNFalpha (200 U ml(-1)).	alpinetin	23-32	tumor necrosis factor	Rattus norvegicus	136-144
35332570-0	2022	Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3beta/Fyn-dependent Nrf2 activation.	alpinetin	0-9	Fyn proto-oncogene	Mus musculus	123-126
35332570-0	2022	Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3beta/Fyn-dependent Nrf2 activation.	alpinetin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
35332570-6	2022	Alpinetin inhibited macrophage adhesion and migration, and the expression of chemokines and adhesion molecules, such as MCP-1, VCAM-1, and ICAM-1.	alpinetin	0-9	mast cell protease 1	Mus musculus	120-125
35332570-6	2022	Alpinetin inhibited macrophage adhesion and migration, and the expression of chemokines and adhesion molecules, such as MCP-1, VCAM-1, and ICAM-1.	alpinetin	0-9	vascular cell adhesion molecule 1	Mus musculus	127-133
35332570-6	2022	Alpinetin inhibited macrophage adhesion and migration, and the expression of chemokines and adhesion molecules, such as MCP-1, VCAM-1, and ICAM-1.	alpinetin	0-9	intercellular adhesion molecule 1	Mus musculus	139-145
35332570-8	2022	Data further showed that alpinetin reduced reactive oxygen species generation and promoted thiol-dependent glutathione and thioredoxin antioxidant systems in macrophages.	alpinetin	25-34	thioredoxin 1	Mus musculus	123-134
35332570-11	2022	Finally, inhibition of Nrf2 in HFD-apoE-/- mice blockaded the effect of alpinetin, which increased aortic macrophage recruitment and aggravated atherosclerosis concurrently with elevating the expression of MCP-1, VCAM-1, and ICAM-1.	alpinetin	72-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
35332570-11	2022	Finally, inhibition of Nrf2 in HFD-apoE-/- mice blockaded the effect of alpinetin, which increased aortic macrophage recruitment and aggravated atherosclerosis concurrently with elevating the expression of MCP-1, VCAM-1, and ICAM-1.	alpinetin	72-81	apolipoprotein E	Mus musculus	35-39
35332570-11	2022	Finally, inhibition of Nrf2 in HFD-apoE-/- mice blockaded the effect of alpinetin, which increased aortic macrophage recruitment and aggravated atherosclerosis concurrently with elevating the expression of MCP-1, VCAM-1, and ICAM-1.	alpinetin	72-81	mast cell protease 1	Mus musculus	206-211
35332570-11	2022	Finally, inhibition of Nrf2 in HFD-apoE-/- mice blockaded the effect of alpinetin, which increased aortic macrophage recruitment and aggravated atherosclerosis concurrently with elevating the expression of MCP-1, VCAM-1, and ICAM-1.	alpinetin	72-81	vascular cell adhesion molecule 1	Mus musculus	213-219
35332570-11	2022	Finally, inhibition of Nrf2 in HFD-apoE-/- mice blockaded the effect of alpinetin, which increased aortic macrophage recruitment and aggravated atherosclerosis concurrently with elevating the expression of MCP-1, VCAM-1, and ICAM-1.	alpinetin	72-81	intercellular adhesion molecule 1	Mus musculus	225-231
35332570-12	2022	Altogether, these findings indicated that alpinetin improved Nrf2-mediated redox homeostasis, which consequently inhibited macrophage infiltration and atherosclerosis, suggesting a useful compound for treating atherosclerosis.	alpinetin	42-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65