PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22393123-10	2012	This study identifies ginkgolide A and ginkgolide B as naturally occurring agonists of hPXR and provides mechanistic insight into the structure-activity relationship in ligand activation of hPXR.	ginkgolide A	22-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	87-91
22393123-5	2012	Concentration-response experiments showed that ginkgolide A and ginkgolide B activated hPXR and rat PXR to a greater extent than ginkgolide C, whereas ginkgolide J had no effect.	ginkgolide A	47-59	nuclear receptor subfamily 1 group I member 2	Homo sapiens	87-91
22393123-5	2012	Concentration-response experiments showed that ginkgolide A and ginkgolide B activated hPXR and rat PXR to a greater extent than ginkgolide C, whereas ginkgolide J had no effect.	ginkgolide A	47-59	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	88-91
22393123-10	2012	This study identifies ginkgolide A and ginkgolide B as naturally occurring agonists of hPXR and provides mechanistic insight into the structure-activity relationship in ligand activation of hPXR.	ginkgolide A	22-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	190-194
22393123-6	2012	As determined by a time-resolved fluorescence resonance energy transfer competitive binding assay, ginkgolide A and ginkgolide B, but not ginkgolide C or ginkgolide J, were shown to bind to the ligand-binding domain of hPXR, consistent with molecular docking data.	ginkgolide A	99-111	nuclear receptor subfamily 1 group I member 2	Homo sapiens	219-223
19218343-7	2009	Additionally, the antioxidants ginsenoside Rb1 and ginkgolide A effectively reversed HAART drug-induced vasomotor dysfunction and eNOS down-regulation.	ginkgolide A	51-63	nitric oxide synthase 3	Homo sapiens	130-134
20739453-4	2010	Likewise, in cultured human hepatocytes, only ginkgolide A contributed to the increase in hPXR target gene expression (CYP3A4 mRNA and CYP3A-mediated testosterone 6beta-hydroxylation).	ginkgolide A	46-58	nuclear receptor subfamily 1 group I member 2	Homo sapiens	90-94
20739453-4	2010	Likewise, in cultured human hepatocytes, only ginkgolide A contributed to the increase in hPXR target gene expression (CYP3A4 mRNA and CYP3A-mediated testosterone 6beta-hydroxylation).	ginkgolide A	46-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	119-125
21571322-12	2011	CONCLUSIONS: GA-GNP reduce vascular SMC proliferation and migration in vitro through reduced activation of ERK1/2.	ginkgolide A	13-15	mitogen-activated protein kinase 3	Mus musculus	107-113
21494357-9	2011	In MAP2, only the co-treatment of ginkgolide A and aspirin showed increasing effect.	ginkgolide A	34-46	microtubule associated protein 2	Homo sapiens	3-7
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	ginkgolide A	133-145	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	ginkgolide A	133-145	ATP binding cassette subfamily C member 2	Homo sapiens	116-120
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	ginkgolide A	147-149	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-88
19034627-4	2009	RESULTS: In human primary hepatocytes, real-time PCR analysis showed induction of CYP2B6, CYP3A4, UGT1A1, MDR1, and MRP2 by EGb 761, ginkgolide A (GA) and ginkgolide B (GB), but not by bilobalide (BB) or the flavonoids (quercetin, kaempferol and tamarixetin) of GBE.	ginkgolide A	147-149	ATP binding cassette subfamily B member 1	Homo sapiens	106-110
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	ginkgolide A	50-52	nuclear receptor subfamily 1 group I member 2	Homo sapiens	85-88
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	ginkgolide A	50-52	nuclear receptor subfamily 1 group I member 3	Homo sapiens	129-132
19034627-5	2009	Cell-based reporter assays in HepG2 revealed that GA and GB are potent activators of PXR; quercetin and kaempferol activate PXR, CAR, and AhR, whereas BB exerts no effects on these xenobiotic receptors.	ginkgolide A	50-52	aryl hydrocarbon receptor	Homo sapiens	138-141
17045319-6	2006	At the level present in a modulating concentration (50 mug/ml) of the extract, ginkgolide A (0.55 mug/ml), which increased CYP3A23 mRNA levels and CYP3A-mediated enzyme activity, accounted for part but not all of the potentiating effect of the extract on acetaminophen toxicity.	ginkgolide A	79-91	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	123-128
17167099-4	2006	We report that EGb 761 and one of its components, ginkgolide A, alleviates Abeta-induced pathological behaviors, including paralysis, and reduces chemotaxis behavior and 5-HT hypersensitivity in a transgenic C. elegans.	ginkgolide A	50-62	amyloid beta precursor protein	Homo sapiens	75-80
17167099-7	2006	These findings suggest that (1) EGb 761 suppresses Abeta-related pathological behaviors, (2) the protection against Abeta toxicity by EGb 761 is mediated primarily by modulating Abeta oligomeric species, and (3) ginkgolide A has therapeutic potential for prevention and treatment of AD.	ginkgolide A	212-224	amyloid beta precursor protein	Homo sapiens	116-121
17581220-2	2007	The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes.	ginkgolide A	59-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	103-108
17581220-11	2007	Ginkgolide A and ginkgolide B can induce CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes at higher doses.	ginkgolide A	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-46
17045319-7	2006	This occurred as a result of CYP3A induction by ginkgolide A because triacetyloleandomycin (TAO), a specific inhibitor of CYP3A catalytic activity, completely blocked the effect of ginkgolide A.	ginkgolide A	48-60	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	29-34
17045319-7	2006	This occurred as a result of CYP3A induction by ginkgolide A because triacetyloleandomycin (TAO), a specific inhibitor of CYP3A catalytic activity, completely blocked the effect of ginkgolide A.	ginkgolide A	48-60	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	122-127
17045319-7	2006	This occurred as a result of CYP3A induction by ginkgolide A because triacetyloleandomycin (TAO), a specific inhibitor of CYP3A catalytic activity, completely blocked the effect of ginkgolide A.	ginkgolide A	181-193	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	29-34
17045319-7	2006	This occurred as a result of CYP3A induction by ginkgolide A because triacetyloleandomycin (TAO), a specific inhibitor of CYP3A catalytic activity, completely blocked the effect of ginkgolide A.	ginkgolide A	181-193	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	122-127
8940403-5	1996	In vivo treatment of rats with EGb, and its bioactive components ginkgolide A and B, specifically reduces the ligand binding capacity, protein, and messenger RNA expression of the adrenocortical mitochondrial peripheral-type benzodiazepine receptor (PBR), a key element in the regulation of cholesterol transport, resulting in decreased corticosteroid synthesis.	ginkgolide A	65-77	translocator protein	Rattus norvegicus	209-248
11226385-8	2001	Taken together, these results suggest that ginkgolide A, ginkgolide B, and bilobalide may contribute to the selective inhibitory effect of EGb on iNOS expression without affecting eNOS-mediated NO production.	ginkgolide A	43-55	nitric oxide synthase 2	Homo sapiens	146-150
23531136-11	2000	Ginkgolide A and B inhibited IL-1, TNF-a and nitric oxide production in rat microglia and prevented the chronic inflammatory process in neurodegenerative diseases.	ginkgolide A	0-12	tumor necrosis factor	Rattus norvegicus	35-40
16259949-2	2005	Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay revealed that blastocysts treated with 5 or 10muM ginkgolide A or ginkgolide B showed increased apoptosis versus untreated controls.	ginkgolide A	126-138	deoxynucleotidyltransferase, terminal	Mus musculus	0-37
12619887-10	2003	EGb and its terpenoids (ginkgolide A, ginkgolide B and bilobalide) could antagonize the homocysteine effect on iNOS expression in macrophages via their antioxidant effect resulting in attenuation of NF-kappaB activation.	ginkgolide A	24-36	nitric oxide synthase 2	Homo sapiens	111-115
12619887-10	2003	EGb and its terpenoids (ginkgolide A, ginkgolide B and bilobalide) could antagonize the homocysteine effect on iNOS expression in macrophages via their antioxidant effect resulting in attenuation of NF-kappaB activation.	ginkgolide A	24-36	nuclear factor kappa B subunit 1	Homo sapiens	199-208
11226385-5	2001	Ginkgolide A, ginkgolide B, or bilobalide (0.25 to 1.0 microg/mL) caused a 30-65% reduction in the levels of NO metabolites released by THP-1 macrophages after 4 hr of incubation, with a corresponding decrease in iNOS activity.	ginkgolide A	0-12	GLI family zinc finger 2	Homo sapiens	136-141
11226385-5	2001	Ginkgolide A, ginkgolide B, or bilobalide (0.25 to 1.0 microg/mL) caused a 30-65% reduction in the levels of NO metabolites released by THP-1 macrophages after 4 hr of incubation, with a corresponding decrease in iNOS activity.	ginkgolide A	0-12	nitric oxide synthase 2	Homo sapiens	213-217
11226385-6	2001	Western immunoblotting analysis coupled with a nuclease protection assay and reverse transcription-polymerase chain reaction revealed a concomitant reduction in the levels of iNOS protein mass and mRNA in ginkgolide A-, ginkgolide B-, or bilobalide-treated macrophages.	ginkgolide A	205-217	nitric oxide synthase 2	Homo sapiens	175-179
8940403-5	1996	In vivo treatment of rats with EGb, and its bioactive components ginkgolide A and B, specifically reduces the ligand binding capacity, protein, and messenger RNA expression of the adrenocortical mitochondrial peripheral-type benzodiazepine receptor (PBR), a key element in the regulation of cholesterol transport, resulting in decreased corticosteroid synthesis.	ginkgolide A	65-77	translocator protein	Rattus norvegicus	250-253
35367419-2	2022	This study aims to explore whether ginkgolide A (GA) could improve cardiac dysfunction of MI mice, and whether it could alleviate cardiac remodeling via binding to matrix metalloproteinase-9 (MMP9) to attenuate inflammation.	ginkgolide A	35-47	matrix metallopeptidase 9	Mus musculus	164-190
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	natriuretic peptide type A	Mus musculus	106-109
35367419-2	2022	This study aims to explore whether ginkgolide A (GA) could improve cardiac dysfunction of MI mice, and whether it could alleviate cardiac remodeling via binding to matrix metalloproteinase-9 (MMP9) to attenuate inflammation.	ginkgolide A	35-47	matrix metallopeptidase 9	Mus musculus	192-196
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	fibronectin 1	Mus musculus	60-71
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	natriuretic peptide type B	Mus musculus	111-114
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	119-127
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	matrix metallopeptidase 9	Mus musculus	154-158
32682918-0	2020	Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis.	ginkgolide A	0-12	nuclear receptor subfamily 1, group I, member 2	Mus musculus	67-70
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	interleukin 1 alpha	Mus musculus	203-211
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	interleukin 6	Mus musculus	213-217
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	tumor necrosis factor	Mus musculus	222-231
35367419-8	2022	The regulatory role of GA in downregulating Col I, Col III, fibronectin in NRCFs, and enhancing levels of ANP, BNP and beta-MHC in NRCMs were reversed by MMP9 overexpression, so as the downregulation of IL-1beta, IL-6 and TNF-alpha in Ang II-induced NRCFs and NRCMs.	ginkgolide A	23-25	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	235-241
35367419-9	2022	GA could alleviate cardiac dysfunction and remodeling via binding to MMP9 to attenuate inflammation.	ginkgolide A	0-2	matrix metallopeptidase 9	Mus musculus	69-73
33677255-0	2021	Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target.	ginkgolide A	0-12	microRNA 25	Mus musculus	73-84
33677255-0	2021	Ginkgolide A attenuates sepsis-associated kidney damage via upregulating microRNA-25 with NADPH oxidase 4 as the target.	ginkgolide A	0-12	NADPH oxidase 4	Mus musculus	90-105
33677255-1	2021	The aim of the present study was to explore the effects of Ginkgolide A (GA) on renal function of mice with sepsis and whether GA could attenuate sepsis-associated inflammation and apoptosis in kidney via upregulating microRNA (miR)-25 with NADPH oxidase 4 (Nox4) as the target.	ginkgolide A	127-129	microRNA 25	Mus musculus	218-235
33677255-1	2021	The aim of the present study was to explore the effects of Ginkgolide A (GA) on renal function of mice with sepsis and whether GA could attenuate sepsis-associated inflammation and apoptosis in kidney via upregulating microRNA (miR)-25 with NADPH oxidase 4 (Nox4) as the target.	ginkgolide A	127-129	NADPH oxidase 4	Mus musculus	241-256
33677255-1	2021	The aim of the present study was to explore the effects of Ginkgolide A (GA) on renal function of mice with sepsis and whether GA could attenuate sepsis-associated inflammation and apoptosis in kidney via upregulating microRNA (miR)-25 with NADPH oxidase 4 (Nox4) as the target.	ginkgolide A	127-129	NADPH oxidase 4	Mus musculus	258-262
33677255-3	2021	GA significantly inhibited the increases of creatinine (Cr), blood urea nitrogen (BUN) and cystatin C (CysC) in the serum of LPS-treated mice.	ginkgolide A	0-2	cystatin C	Mus musculus	91-101
33677255-3	2021	GA significantly inhibited the increases of creatinine (Cr), blood urea nitrogen (BUN) and cystatin C (CysC) in the serum of LPS-treated mice.	ginkgolide A	0-2	cystatin C	Mus musculus	103-107
33677255-4	2021	The increases of inflammatory factors including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in the kidneys of LPS-treated mice or NRK-52E cells were inhibited by GA administration.	ginkgolide A	185-187	tumor necrosis factor	Mus musculus	48-81
33677255-4	2021	The increases of inflammatory factors including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in the kidneys of LPS-treated mice or NRK-52E cells were inhibited by GA administration.	ginkgolide A	185-187	interleukin 1 alpha	Mus musculus	83-105
33677255-4	2021	The increases of inflammatory factors including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in the kidneys of LPS-treated mice or NRK-52E cells were inhibited by GA administration.	ginkgolide A	185-187	interleukin 6	Mus musculus	110-114
33677255-5	2021	The changes of cleaved-caspase 3, cleaved-caspase 8, Bax, Bcl2 in mouse kidney and NRK-52E cells treated by LPS were reversed by GA administration.	ginkgolide A	129-131	caspase 8	Mus musculus	42-51
33677255-5	2021	The changes of cleaved-caspase 3, cleaved-caspase 8, Bax, Bcl2 in mouse kidney and NRK-52E cells treated by LPS were reversed by GA administration.	ginkgolide A	129-131	BCL2-associated X protein	Mus musculus	53-56
33677255-5	2021	The changes of cleaved-caspase 3, cleaved-caspase 8, Bax, Bcl2 in mouse kidney and NRK-52E cells treated by LPS were reversed by GA administration.	ginkgolide A	129-131	B cell leukemia/lymphoma 2	Mus musculus	58-62
33677255-6	2021	The sepsis-induced decrease of miR-25 was enhanced by GA treatment.	ginkgolide A	54-56	microRNA 25	Rattus norvegicus	31-37
33677255-10	2021	These results indicated that GA could improve sepsis-induced renal damage by attenuating renal inflammation and apoptosis via upregulating miR-25 with Nox4 as the target.	ginkgolide A	29-31	microRNA 25	Rattus norvegicus	139-145
33677255-10	2021	These results indicated that GA could improve sepsis-induced renal damage by attenuating renal inflammation and apoptosis via upregulating miR-25 with Nox4 as the target.	ginkgolide A	29-31	NADPH oxidase 4	Rattus norvegicus	151-155
32682918-3	2020	We previously showed that Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ).	ginkgolide A	26-38	nuclear receptor subfamily 1, group I, member 2	Mus musculus	55-58
32682918-3	2020	We previously showed that Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ).	ginkgolide A	40-42	nuclear receptor subfamily 1, group I, member 2	Mus musculus	55-58
32682918-4	2020	Here, we aimed to investigate the effect of GA in activating PXR and associated antimicrobial peptides (AMPs) in regulating BT in experimental cirrhosis.	ginkgolide A	44-46	nuclear receptor subfamily 1, group I, member 2	Mus musculus	61-64
32682918-8	2020	RESULTS: GA treatment to cirrhotic mice significantly increased the expression of small intestinal PXR and Regenerating family member 3 alpha (Reg3A), which were otherwise reduced in CCl4 cirrhotic mice.	ginkgolide A	9-11	regenerating islet-derived 3 alpha	Mus musculus	143-148
32682918-12	2020	CONCLUSION: The study showed for the first time that, GA treatment to cirrhotic rodents attenuates BT, by improving PXR and Reg3A expression.	ginkgolide A	54-56	nuclear receptor subfamily 1, group I, member 2	Mus musculus	116-119
32682918-12	2020	CONCLUSION: The study showed for the first time that, GA treatment to cirrhotic rodents attenuates BT, by improving PXR and Reg3A expression.	ginkgolide A	54-56	regenerating islet-derived 3 alpha	Mus musculus	124-129
31697926-0	2020	Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis.	ginkgolide A	53-63	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-19
31697926-4	2020	Ginkgolide A (GA), a terpene trilactone from Ginkgo Biloba extract, is a natural ligand of rodent and human PXR.	ginkgolide A	0-12	nuclear receptor subfamily 1 group I member 2	Homo sapiens	108-111
31697926-4	2020	Ginkgolide A (GA), a terpene trilactone from Ginkgo Biloba extract, is a natural ligand of rodent and human PXR.	ginkgolide A	14-16	nuclear receptor subfamily 1 group I member 2	Homo sapiens	108-111
31697926-5	2020	This study aims to investigate the effect of GA in activating PXR and improving associated tight junction integrity and reducing bacterial translocation in gut-liver axis of CCl4 induced cirrhosis model.	ginkgolide A	45-47	nuclear receptor subfamily 1, group I, member 2	Mus musculus	62-65
31697926-5	2020	This study aims to investigate the effect of GA in activating PXR and improving associated tight junction integrity and reducing bacterial translocation in gut-liver axis of CCl4 induced cirrhosis model.	ginkgolide A	45-47	chemokine (C-C motif) ligand 4	Mus musculus	174-178
31697926-10	2020	Treatment with GA to cirrhotic mice significantly (p < 0.05) induced the expression of both hepatic and small intestinal PXR, CYP3A, ZO-1 and Occludin.	ginkgolide A	15-17	nuclear receptor subfamily 1, group I, member 2	Mus musculus	124-127
31697926-10	2020	Treatment with GA to cirrhotic mice significantly (p < 0.05) induced the expression of both hepatic and small intestinal PXR, CYP3A, ZO-1 and Occludin.	ginkgolide A	15-17	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	129-134
31697926-10	2020	Treatment with GA to cirrhotic mice significantly (p < 0.05) induced the expression of both hepatic and small intestinal PXR, CYP3A, ZO-1 and Occludin.	ginkgolide A	15-17	tight junction protein 1	Mus musculus	136-153
31697926-11	2020	Furthermore, increased (p < 0.01) hepatic and small intestinal NFkappaB was observed in CCl4 induced cirrhotic mice that was significantly (p < 0.05) lowered following GA treatment.	ginkgolide A	174-176	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-74
31697926-11	2020	Furthermore, increased (p < 0.01) hepatic and small intestinal NFkappaB was observed in CCl4 induced cirrhotic mice that was significantly (p < 0.05) lowered following GA treatment.	ginkgolide A	174-176	chemokine (C-C motif) ligand 4	Mus musculus	91-95
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	toll-like receptor 4	Mus musculus	19-23
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	myeloid differentiation primary response gene 88	Mus musculus	24-29
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	30-38
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	tumor necrosis factor	Mus musculus	90-99
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	interleukin 6	Mus musculus	101-104
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	interferon gamma	Mus musculus	109-118
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	chemokine (C-C motif) ligand 4	Mus musculus	136-140
31697926-13	2020	Furthermore, significantly increased plasma levels of bacterial translocation markers LBP and procalcitonin were found in CCl4 mice, which were reduced significantly (p < 0.05 & p < 0.0001) after GA treatment.	ginkgolide A	206-208	lipopolysaccharide binding protein	Mus musculus	86-89
31697926-13	2020	Furthermore, significantly increased plasma levels of bacterial translocation markers LBP and procalcitonin were found in CCl4 mice, which were reduced significantly (p < 0.05 & p < 0.0001) after GA treatment.	ginkgolide A	206-208	chemokine (C-C motif) ligand 4	Mus musculus	122-126
31697926-14	2020	CONCLUSION: In conclusion, our data supports the hypothesis that, GA treatment to CCl4 induced cirrhotic mice, activated hepatic and small intestinal PXR and diminished inflammation, thereby improving tight junction integrity and attenuating bacterial translocation.	ginkgolide A	66-68	chemokine (C-C motif) ligand 4	Mus musculus	82-86
31697926-14	2020	CONCLUSION: In conclusion, our data supports the hypothesis that, GA treatment to CCl4 induced cirrhotic mice, activated hepatic and small intestinal PXR and diminished inflammation, thereby improving tight junction integrity and attenuating bacterial translocation.	ginkgolide A	66-68	nuclear receptor subfamily 1, group I, member 2	Mus musculus	150-153
25681539-0	2015	Ginkgolide A reduces inflammatory response in high-glucose-stimulated human umbilical vein endothelial cells through STAT3-mediated pathway.	ginkgolide A	0-12	signal transducer and activator of transcription 3	Homo sapiens	117-122
26759700-0	2016	PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice.	ginkgolide A	54-66	nuclear receptor subfamily 1, group I, member 2	Mus musculus	0-3
26759700-3	2016	Ginkgolide A, one main component of Ginkgo biloba extracts (GBE), activated PXR and enhanced PXR expression level, displayed both significant therapeutic effect and preventive effect against CCl4-induced mouse hepatitis.	ginkgolide A	0-12	nuclear receptor subfamily 1, group I, member 2	Mus musculus	76-79
26759700-3	2016	Ginkgolide A, one main component of Ginkgo biloba extracts (GBE), activated PXR and enhanced PXR expression level, displayed both significant therapeutic effect and preventive effect against CCl4-induced mouse hepatitis.	ginkgolide A	0-12	nuclear receptor subfamily 1, group I, member 2	Mus musculus	93-96
26759700-3	2016	Ginkgolide A, one main component of Ginkgo biloba extracts (GBE), activated PXR and enhanced PXR expression level, displayed both significant therapeutic effect and preventive effect against CCl4-induced mouse hepatitis.	ginkgolide A	0-12	chemokine (C-C motif) ligand 4	Mus musculus	191-195
26759700-4	2016	siRNA-mediated decrease of PXR expression significantly reduced the efficacy of Ginkgolide A in treating CCl4-induced inflammation in mice.	ginkgolide A	80-92	nuclear receptor subfamily 1, group I, member 2	Mus musculus	27-30
26759700-4	2016	siRNA-mediated decrease of PXR expression significantly reduced the efficacy of Ginkgolide A in treating CCl4-induced inflammation in mice.	ginkgolide A	80-92	chemokine (C-C motif) ligand 4	Mus musculus	105-109
26759700-7	2016	Inhibition of NF-kappaB activity by NF-kappaB-specific suppressor IkappaBalpha is one of the potential mechanisms of Ginkgolide A against CCl4-induced liver inflammation.	ginkgolide A	117-129	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	66-78
26759700-7	2016	Inhibition of NF-kappaB activity by NF-kappaB-specific suppressor IkappaBalpha is one of the potential mechanisms of Ginkgolide A against CCl4-induced liver inflammation.	ginkgolide A	117-129	chemokine (C-C motif) ligand 4	Mus musculus	138-142
30541279-3	2019	Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid beta (Abeta)-induced abnormal depolarization in mouse primary cortical neurons.	ginkgolide A	28-40	amyloid beta (A4) precursor protein	Mus musculus	130-135
30541279-3	2019	Using a screening platform, ginkgolide A (GA), a pure compound extracted from Ginkgo biloba, was found to attenuate amyloid beta (Abeta)-induced abnormal depolarization in mouse primary cortical neurons.	ginkgolide A	42-44	amyloid beta (A4) precursor protein	Mus musculus	130-135
30541279-5	2019	Furthermore, the Abeta-induced increase in c-Jun N-terminal kinase phosphorylation in neurons was prevented by GA.	ginkgolide A	111-113	amyloid beta (A4) precursor protein	Mus musculus	17-22
28394269-5	2017	We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro.	ginkgolide A	15-17	prostaglandin-endoperoxide synthase 2	Mus musculus	79-95
28394269-5	2017	We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro.	ginkgolide A	15-17	prostaglandin-endoperoxide synthase 2	Mus musculus	97-102
28394269-5	2017	We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro.	ginkgolide A	15-17	tumor necrosis factor	Mus musculus	158-191
28394269-5	2017	We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro.	ginkgolide A	15-17	interleukin 6	Mus musculus	193-211
28394269-5	2017	We showed that GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-1beta) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro.	ginkgolide A	15-17	interleukin 1 beta	Mus musculus	216-224
28394269-7	2017	Consistently, GA was also shown to inhibit the LPS-stimulated release of TNF-alpha and IL-6 in mice.	ginkgolide A	14-16	tumor necrosis factor	Mus musculus	73-82
28394269-7	2017	Consistently, GA was also shown to inhibit the LPS-stimulated release of TNF-alpha and IL-6 in mice.	ginkgolide A	14-16	interleukin 6	Mus musculus	87-91
29441927-0	2016	Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-kappaB signaling through PI3K/Akt pathway.	ginkgolide A	0-12	toll like receptor 4	Homo sapiens	136-140
29441927-0	2016	Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-kappaB signaling through PI3K/Akt pathway.	ginkgolide A	0-12	nuclear factor kappa B subunit 1	Homo sapiens	141-150
29441927-0	2016	Ginkgolide A inhibits lipopolysaccharide-induced inflammatory response in human coronary artery endothelial cells via downregulation of TLR4-NF-kappaB signaling through PI3K/Akt pathway.	ginkgolide A	0-12	AKT serine/threonine kinase 1	Homo sapiens	174-177
29441927-8	2016	GA and CLI-095 abolished the LPS-induced inflammatory mediator release and NF-kappaB signaling activation, and GA reduced the TLR4 mRNA expression without affecting cell viability.	ginkgolide A	0-2	nuclear factor kappa B subunit 1	Homo sapiens	75-84
29441927-9	2016	However, PI3K/Akt blocking abolished the effects of GA on HCAECs.	ginkgolide A	52-54	AKT serine/threonine kinase 1	Homo sapiens	14-17
29441927-10	2016	We conclude that GA could attenuate the LPS-induced inflammatory response in HCAECs and the anti-inflammatory activity might be associated with the inhibition of TLR4-NF-kappaB signaling through PI3K/AKT pathway.	ginkgolide A	17-19	toll like receptor 4	Homo sapiens	162-166
29441927-10	2016	We conclude that GA could attenuate the LPS-induced inflammatory response in HCAECs and the anti-inflammatory activity might be associated with the inhibition of TLR4-NF-kappaB signaling through PI3K/AKT pathway.	ginkgolide A	17-19	nuclear factor kappa B subunit 1	Homo sapiens	167-176
29441927-10	2016	We conclude that GA could attenuate the LPS-induced inflammatory response in HCAECs and the anti-inflammatory activity might be associated with the inhibition of TLR4-NF-kappaB signaling through PI3K/AKT pathway.	ginkgolide A	17-19	AKT serine/threonine kinase 1	Homo sapiens	200-203
25681539-5	2015	The endothelial production of high-glucose-induced interleukin (IL)-4, IL-6, IL-13 and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly inhibited by the pretreatment with GA at concentrations of 10, 15 and 20muM based on enzyme-linked immunosorbent assay (ELISA), western blot or/and RT-PCR experiments.	ginkgolide A	217-219	interleukin 6	Homo sapiens	71-75
25681539-5	2015	The endothelial production of high-glucose-induced interleukin (IL)-4, IL-6, IL-13 and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly inhibited by the pretreatment with GA at concentrations of 10, 15 and 20muM based on enzyme-linked immunosorbent assay (ELISA), western blot or/and RT-PCR experiments.	ginkgolide A	217-219	interleukin 13	Homo sapiens	77-82
25681539-5	2015	The endothelial production of high-glucose-induced interleukin (IL)-4, IL-6, IL-13 and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly inhibited by the pretreatment with GA at concentrations of 10, 15 and 20muM based on enzyme-linked immunosorbent assay (ELISA), western blot or/and RT-PCR experiments.	ginkgolide A	217-219	signal transducer and activator of transcription 3	Homo sapiens	87-137
25681539-5	2015	The endothelial production of high-glucose-induced interleukin (IL)-4, IL-6, IL-13 and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly inhibited by the pretreatment with GA at concentrations of 10, 15 and 20muM based on enzyme-linked immunosorbent assay (ELISA), western blot or/and RT-PCR experiments.	ginkgolide A	217-219	signal transducer and activator of transcription 3	Homo sapiens	139-145
24327346-0	2014	Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats.	ginkgolide A	61-74	mitogen-activated protein kinase 8	Rattus norvegicus	169-192
24386395-9	2013	The natural antioxidant Ginkgolide A effectively inhibited resistin-induced increase in permeability and the increase in superoxide anion production in HCAECs.	ginkgolide A	24-36	resistin	Homo sapiens	59-67