PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24051386-2	2013	The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele.	thcy	133-137	methylenetetrahydrofolate reductase	Homo sapiens	147-152
22676332-1	2013	We examined the relationship between the 677C >T polymorphism in the MTHFR gene and tHcy in normotensive (NT) and hypertensive (HT) subjects and the influence of sex and age in a cross-sectional study.	thcy	87-91	methylenetetrahydrofolate reductase	Homo sapiens	72-77
22676332-4	2013	We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.	thcy	69-73	methylenetetrahydrofolate reductase	Homo sapiens	46-51
23181804-9	2013	The concentration of tHcy and BNP in patients with RRF was decreased in comparison with those without RRF.	thcy	21-25	mitochondrial ribosome recycling factor	Homo sapiens	51-54
24167429-7	2013	Multiple regression analysis has shown that tHcy level in CT and TT genotypes of MTHFR (C677T) was statistically higher in comparison with CC genotype of MTHFR (C677T) in both, the control group and the DVT patients.	thcy	44-48	methylenetetrahydrofolate reductase	Homo sapiens	81-86
24167429-7	2013	Multiple regression analysis has shown that tHcy level in CT and TT genotypes of MTHFR (C677T) was statistically higher in comparison with CC genotype of MTHFR (C677T) in both, the control group and the DVT patients.	thcy	44-48	methylenetetrahydrofolate reductase	Homo sapiens	154-159
24455405-7	2013	This study is the first to explore the relationship between KIF6 719Arg carrier status with tHcy and CRP levels.	thcy	92-96	kinesin family member 6	Homo sapiens	60-64
21358708-2	2012	The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase gene (MTHFR) increases basal tHcy, but its contribution to cognitive impairment has not been established.	thcy	100-104	methylenetetrahydrofolate reductase	Homo sapiens	35-70
22782530-1	2012	The methylenetetrahydrofolate reductase (MTHFR) 677 C T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease.	thcy	121-125	methylenetetrahydrofolate reductase	Homo sapiens	4-39
22782530-1	2012	The methylenetetrahydrofolate reductase (MTHFR) 677 C T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease.	thcy	121-125	methylenetetrahydrofolate reductase	Homo sapiens	41-46
22770603-6	2012	Men with the MTHFR TT homozygosity had significantly higher tHcy concentration than those with the CC genotype (mean difference of 1.38 mumol/l, 95% CI 0.77-1.99).	thcy	60-64	methylenetetrahydrofolate reductase	Homo sapiens	13-18
22897803-3	2012	The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.	thcy	183-187	methylenetetrahydrofolate reductase	Homo sapiens	63-98
22897803-3	2012	The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular filtration rate (eGFR) in Chinese.	thcy	183-187	methylenetetrahydrofolate reductase	Homo sapiens	100-105
22425007-3	2012	The present study aimed to assess the role of antiepileptic drugs (AEDs) and C677T methylenetetrahydrofolate (MTHFR) polymorphisms on tHcy in pediatric patients with epilepsy treated for at least 6 months with various treatment regimens protocols including the newer AEDs.	thcy	134-138	methylenetetrahydrofolate reductase	Homo sapiens	110-115
22084937-1	2012	In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome.	thcy	281-285	methylenetetrahydrofolate reductase	Homo sapiens	61-96
22084937-1	2012	In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome.	thcy	281-285	methylenetetrahydrofolate reductase	Homo sapiens	98-103
22084937-6	2012	The MTHFR 677 TT genotype has decreasing effect in B12 vitamin and increasing effect in tHcy.	thcy	88-92	methylenetetrahydrofolate reductase	Homo sapiens	4-9
21358708-2	2012	The C677T polymorphism of the 5,10 methylenetetrahydrofolate reductase gene (MTHFR) increases basal tHcy, but its contribution to cognitive impairment has not been established.	thcy	100-104	methylenetetrahydrofolate reductase	Homo sapiens	77-82
21358708-3	2012	We designed this study to determine if tHcy is causally related to cognitive impairment in later life by investigating its association with high tHcy and the MTHFR-C677T polymorphism.	thcy	39-43	methylenetetrahydrofolate reductase	Homo sapiens	158-163
22652373-4	2012	We hypothesized that the NOS3 synthase 4a4b VNTR polymorphism is a determinant of tHcy concentrations and tested this in 310 patients with MI and 250 controls.	thcy	82-86	nitric oxide synthase 3	Homo sapiens	25-29
22652373-8	2012	In patients with MI, plasma tHcy concentrations were significantly different among the NOS3 genotypes (13.5+-4.5, 18.5+-3.9, and 20.4+-2.1 mumol/L for 4b4b, 4a4b, and 4a4a genotypes, respectively; P<.001).	thcy	28-32	nitric oxide synthase 3	Homo sapiens	87-91
22507617-2	2012	The gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) is reported to be a genetic factor for influencing tHcy.	thcy	120-124	methylenetetrahydrofolate reductase	Homo sapiens	25-60
25101809-10	2012	Child"s 2y tHcy concentration was high (11.4 +- 3.6 mum) and predicted by lower pregnancy vitamin B12 (std beta -0.206, R 2 4.1%), lack of vitamin supplementation (std beta -0.256, R 2 5.6%) in pregnancy and whether currently breastfed (std beta 0.268, R 2 8.4%).	thcy	11-15	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	98-101
22507617-2	2012	The gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) is reported to be a genetic factor for influencing tHcy.	thcy	120-124	methylenetetrahydrofolate reductase	Homo sapiens	62-67
22507617-8	2012	Therefore, MTHFR genotypes were proven to be a significant determinant for folate and tHcy concentrations.	thcy	86-90	methylenetetrahydrofolate reductase	Homo sapiens	11-16
21669453-4	2011	RESULTS: Baseline; tHcy was highest in MTHFR++ carriers (p < 0,05); 8-iso-PGF(2alpha) and 11-dehydro-TXB(2) levels were independent of sex, MTHFR++ and/or CBSins + (p > 0.05).	thcy	19-23	methylenetetrahydrofolate reductase	Homo sapiens	39-44
20676649-7	2012	Levels of tHcy were inversely related to BMD at the lumbar spine, at the total hip and plasma vitamin B12 and positively related to age and creatinine.	thcy	10-14	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	102-105
21746742-2	2012	The C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) increases tHcy and provides a means of studying the association between tHcy and dementia while not being as susceptible to the common biases and confounding of observational studies.	thcy	94-98	methylenetetrahydrofolate reductase	Homo sapiens	77-82
21746742-2	2012	The C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) increases tHcy and provides a means of studying the association between tHcy and dementia while not being as susceptible to the common biases and confounding of observational studies.	thcy	156-160	methylenetetrahydrofolate reductase	Homo sapiens	77-82
21669453-4	2011	RESULTS: Baseline; tHcy was highest in MTHFR++ carriers (p < 0,05); 8-iso-PGF(2alpha) and 11-dehydro-TXB(2) levels were independent of sex, MTHFR++ and/or CBSins + (p > 0.05).	thcy	19-23	methylenetetrahydrofolate reductase	Homo sapiens	143-148
21669453-6	2011	Mean PML tHcy was maximal in MTHFR++ carriers (p = 0.000).	thcy	9-13	methylenetetrahydrofolate reductase	Homo sapiens	29-34
22419201-2	2011	OBJECTIVE: To explore the gender differences in tHcy in relation to determinants of one-carbon metabolism in Indian people with low B12 and adequate folate.	thcy	48-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	132-135
22419201-10	2011	Women with a tHcy of 9.3 microM had the same B12 concentration (129 pmol/L) as men with a tHcy of 15 microM; and for a tHcy of 10.0 micromol/L women had the same RCF concentration (533 nmol/L) as men with a tHcy of 15 micromol/L.	thcy	13-17	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	45-48
21367581-1	2011	OBJECTIVE: The aim was to investigate whether pregnancy-induced changes in total homocysteine (tHcy) are associated with folate and vitamin B12 nutritional status, genetic C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) enzyme, and gestation outcome at a time when folic acid supplementation started to be recommended in the Spanish health system.	thcy	95-99	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	140-143
21838883-5	2011	RESULTS: Plasma tHcy but not tCys correlated negatively with ApoA-I (r = -0.153, P < 0.001) and with HDL cholesterol (r = -0.148, P < 0.001), and correlated positively with the risk of CAD (OR: 1.61; 95% confidence interval; 1.26 to 2.05).	thcy	16-20	apolipoprotein A1	Homo sapiens	61-67
21838883-6	2011	Combination of high tHcy and high tCys levels was associated with decreased ApoA-I and HDL cholesterol levels, and with increased risk of CAD (OR: 1.696, 95% CI (1.301-2.211)).	thcy	20-24	apolipoprotein A1	Homo sapiens	76-82
21250986-2	2011	We tested the hypothesis that elevated tHcy levels are correlated with hippocampus volume and insulin resistance in nondementia patients with type 2 diabetes.	thcy	39-43	insulin	Homo sapiens	94-101
21567442-11	2011	CONCLUSION: This work implicates up-regulation of PC synthesis by the PEMT pathway as a source of elevated plasma and bile tHcy during cholesterol cholelithogenesis.	thcy	123-127	phosphatidylethanolamine N-methyltransferase	Mus musculus	70-74
21250986-8	2011	CONCLUSIONS: Our results indicate that the elevated levels of tHcy in Japanese nondementia patients with type 2 diabetes are characterised by hippocampal atrophy and insulin resistance and that the Z-score and HOMA index may be the primary factors that influence tHcy levels.	thcy	62-66	insulin	Homo sapiens	166-173
21575532-14	2011	However, in a significant proportion of patients tHcy and Lp(a) levels were reduced to control levels (tHcy: p < 0.001, Lp(a): p < 0.01).	thcy	103-107	lipoprotein(a)	Homo sapiens	58-63
21575532-16	2011	Since both tHcy and Lp(a) levels responded in a similar fashion, a common point of the metabolic and pathogenetic pathways of tHcy and Lp(a) may be influenced by the vitamins supplementation.	thcy	126-130	lipoprotein(a)	Homo sapiens	20-25
20808328-8	2010	Among individuals with vitamin B(12) concentrations in the lower half of the distribution, tHcy concentrations were higher in TCN2 776GG homozygotes than in individuals with the other genotypes (P(unadjusted)=0.015; P(adjusted)=0.06).	thcy	91-95	transcobalamin 2	Homo sapiens	126-130
19854035-6	2011	In the high-tHcy group, tHcy level was also positively correlated with IL-1beta, TNF-alpha, oxLDL, and blood pressure; and negatively correlated with LDL particle size.	thcy	12-16	interleukin 1 beta	Homo sapiens	71-79
19854035-6	2011	In the high-tHcy group, tHcy level was also positively correlated with IL-1beta, TNF-alpha, oxLDL, and blood pressure; and negatively correlated with LDL particle size.	thcy	12-16	tumor necrosis factor	Homo sapiens	81-90
19854035-6	2011	In the high-tHcy group, tHcy level was also positively correlated with IL-1beta, TNF-alpha, oxLDL, and blood pressure; and negatively correlated with LDL particle size.	thcy	24-28	interleukin 1 beta	Homo sapiens	71-79
19854035-6	2011	In the high-tHcy group, tHcy level was also positively correlated with IL-1beta, TNF-alpha, oxLDL, and blood pressure; and negatively correlated with LDL particle size.	thcy	24-28	tumor necrosis factor	Homo sapiens	81-90
20808328-10	2010	Furthermore, vitamin B(12) status influences the relationship between TCN2 776C>G genotype and tHcy concentrations.	thcy	98-102	transcobalamin 2	Homo sapiens	70-74
20808328-11	2010	Thus, the TCN2 776C>G polymorphism may contribute to the risk of pathologies associated with a low B(12), and high tHcy phenotype.	thcy	118-122	transcobalamin 2	Homo sapiens	10-14
19764044-2	2009	MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status.	thcy	117-121	methylenetetrahydrofolate reductase	Meleagris gallopavo	0-5
20530057-1	2010	Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration.	thcy	214-218	methylenetetrahydrofolate reductase	Homo sapiens	88-123
20530057-1	2010	Coronary artery diseases (CAD) are influenced by multiple genes of modest effect as the methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, related to MTHFR activity and total plasma homocysteine (tHcy) concentration.	thcy	214-218	methylenetetrahydrofolate reductase	Homo sapiens	125-130
20097536-1	2010	OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	thcy	249-253	methylenetetrahydrofolate reductase	Homo sapiens	151-186
20097536-1	2010	OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	thcy	249-253	methylenetetrahydrofolate reductase	Homo sapiens	188-193
20097536-14	2010	Also, consumption of folate-fortified foods modulates the association of the MTHFR 677C>T polymorphism with tHcy, suggesting that habitual consumption of folate-fortified foods is a practical approach in providing consistent protection to those children who may benefit the most, i.e., carriers of the TT genotype.	thcy	111-115	methylenetetrahydrofolate reductase	Homo sapiens	77-82
20544798-8	2010	RESULTS: In African American women, tHcy concentrations were associated (p < 0.05) with total RBC folate, RBC 5-MTHF, B(12), and polymorphisms in methionine synthase (MTR) and thymidylate synthase (TYMS).	thcy	36-40	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	149-168
20544798-8	2010	RESULTS: In African American women, tHcy concentrations were associated (p < 0.05) with total RBC folate, RBC 5-MTHF, B(12), and polymorphisms in methionine synthase (MTR) and thymidylate synthase (TYMS).	thcy	36-40	thymidylate synthetase	Homo sapiens	179-199
20544798-8	2010	RESULTS: In African American women, tHcy concentrations were associated (p < 0.05) with total RBC folate, RBC 5-MTHF, B(12), and polymorphisms in methionine synthase (MTR) and thymidylate synthase (TYMS).	thcy	36-40	thymidylate synthetase	Homo sapiens	201-205
20670473-3	2010	C677T polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have impacts on tHcy level; it is suspected to influence cognitive function, but only few investigations have assessed its effects on non-dementia adults and the results have been controversial.	thcy	97-101	methylenetetrahydrofolate reductase	Homo sapiens	27-67
20670473-3	2010	C677T polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have impacts on tHcy level; it is suspected to influence cognitive function, but only few investigations have assessed its effects on non-dementia adults and the results have been controversial.	thcy	97-101	methylenetetrahydrofolate reductase	Homo sapiens	69-74
20670473-9	2010	Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function.	thcy	146-150	methylenetetrahydrofolate reductase	Homo sapiens	31-36
20670473-9	2010	Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function.	thcy	276-280	methylenetetrahydrofolate reductase	Homo sapiens	31-36
19909787-3	2010	The contemporary occurrence of C677T polymorphism in homozygosity, leading to a temperature-labile variant of the MTHFR enzyme, induces an even more marked increase in tHcy.	thcy	168-172	methylenetetrahydrofolate reductase	Homo sapiens	114-119
20092401-7	2010	In a multiple regression model, the plasma CF6 level was weakly correlated to the total Hcy (tHcy) level.	thcy	93-97	ATP synthase peripheral stalk subunit F6	Homo sapiens	43-46
20092401-9	2010	In Group 2, however, they were both decreased, and there was a weak positive correlation between the decreases in plasma levels of CF6 and tHcy.	thcy	139-143	ATP synthase peripheral stalk subunit F6	Homo sapiens	131-134
20798494-8	2010	The tHcy levels were significantly and inversely correlated with folate levels in the TNF-alpha-308GG and TNF-alpha-238GG genotypes in the ischemic stroke, SBI, and control groups (p< 0.05).	thcy	4-8	tumor necrosis factor	Homo sapiens	86-95
20798494-8	2010	The tHcy levels were significantly and inversely correlated with folate levels in the TNF-alpha-308GG and TNF-alpha-238GG genotypes in the ischemic stroke, SBI, and control groups (p< 0.05).	thcy	4-8	tumor necrosis factor	Homo sapiens	106-115
20798494-9	2010	CONCLUSIONS: Our results suggest that the TNF-alpha-308G A polymorphism is responsible for susceptibility to ischemic stroke and is associated with high tHcy levels in Koreans.	thcy	153-157	tumor necrosis factor	Homo sapiens	42-51
20113291-1	2010	The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen.	thcy	191-195	methylenetetrahydrofolate reductase	Homo sapiens	21-63
20113291-1	2010	The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen.	thcy	191-195	methylenetetrahydrofolate reductase	Homo sapiens	65-70
20036517-5	2010	Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity.	thcy	34-38	cystathionine beta-synthase	Mus musculus	8-11
20580582-3	2010	PURPOSE: The purpose of this research was to investigate the relationship between TS polymorphisms and total plasma homocysteine (tHcy) levels.	thcy	130-134	thymidylate synthetase	Homo sapiens	82-84
20580582-8	2010	The combined effect of the TS polymorphisms was also found to be associated with tHcy concentration (p=0.05).	thcy	81-85	thymidylate synthetase	Homo sapiens	27-29
20580582-10	2010	CONCLUSIONS: The findings of this research provide evidence of an association between TS polymorphisms and tHcy concentrations.	thcy	107-111	thymidylate synthetase	Homo sapiens	86-88
20544798-9	2010	In Caucasian women, tHcy concentrations were not associated with total folate levels, but were associated (p < 0.05) with RBC THF, ratios of RBC 5-MTHF:THF, and polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) and MTR.	thcy	20-24	methylenetetrahydrofolate reductase	Homo sapiens	181-221
20544798-9	2010	In Caucasian women, tHcy concentrations were not associated with total folate levels, but were associated (p < 0.05) with RBC THF, ratios of RBC 5-MTHF:THF, and polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) and MTR.	thcy	20-24	methylenetetrahydrofolate reductase	Homo sapiens	223-228
19943806-4	2010	In the present study, we investigated the association between plasma tHcy and apoE status.	thcy	69-73	apolipoprotein E	Homo sapiens	78-82
19943806-6	2010	RESULTS: Plasma tHcy concentrations were increased (p<0.01) in carriers of APOE4 (13.6 micromol/L; 9.2-21.7 micromol/L) compared to non-carriers (12.4 micromol/L; 8.3-19.9 micromol/L).	thcy	16-20	apolipoprotein E	Homo sapiens	78-83
19943806-10	2010	Furthermore, the association between plasma tHcy and the presence of APOE4 might be attributed to an increased proportion of vascular disease in APOE4 carriers.	thcy	44-48	apolipoprotein E	Homo sapiens	69-74
19943806-10	2010	Furthermore, the association between plasma tHcy and the presence of APOE4 might be attributed to an increased proportion of vascular disease in APOE4 carriers.	thcy	44-48	apolipoprotein E	Homo sapiens	145-150
19764044-2	2009	MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect folate and total homocysteine (tHcy) status.	thcy	117-121	methylenetetrahydrofolate reductase	Meleagris gallopavo	33-38
19764044-5	2009	The MTHFR 677C->T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits.	thcy	80-84	methylenetetrahydrofolate reductase	Meleagris gallopavo	4-9
19764044-6	2009	In homozygote subjects for MTHFR 677C->T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype; all subjects had lower serum folate and 54% of the subjects had higher tHcy concentrations than the cutoff values of <or=10 nmol/L and >or=12 micromol/L, respectively.	thcy	225-229	methylenetetrahydrofolate reductase	Meleagris gallopavo	27-32
19764044-9	2009	These data show that the rate of MTHFR 677C->T and 1298A->C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations.	thcy	119-123	methylenetetrahydrofolate reductase	Meleagris gallopavo	33-38
19936026-15	2009	CONCLUSION: The TT and AC genotypes of MTHFR C677T and A1298C polymorphisms and the combined genotype TTAC were associated with PCAG in Punjabi subjects of Pakistani origin and correlated with the high serum tHcy levels seen in these patients.	thcy	208-212	methylenetetrahydrofolate reductase	Homo sapiens	39-44
19846961-8	2009	CONCLUSION: The MTHFR polymorphisms do not significantly contribute to tHcy (total Hcy) levels in cancer patients, and cancer-related inflammation may be associated with elevated tHcy levels, possibly involving a TNF-alpha mediated pathway.	thcy	179-183	tumor necrosis factor	Homo sapiens	213-222
19282159-7	2009	Compared to the control group, COPD was associated with higher tHcy concentrations also after adjusting for smoking, heart failure, renal function and C-reactive protein with logistic regression analysis (OR 1.36, 95% CI 1.06-1.72, p=0.01).	thcy	63-67	C-reactive protein	Homo sapiens	151-169
19219535-1	2009	BACKGROUND: The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD).	thcy	209-213	methylenetetrahydrofolate reductase	Homo sapiens	104-138
19428278-8	2009	Among healthy Czech controls, 9.3% were homozygous for CTH c.1208G>T (p.Ser403Ile), previously found homozygously in 7.5% of Canadians for whom plasma total homocysteine (tHcy) had been measured.	thcy	174-178	V-set and immunoglobulin domain containing 2	Homo sapiens	55-58
19428278-10	2009	Three of the four individuals homozygous or compound heterozygous for inactivating CTH mutations had mild plasma tHcy elevations, perhaps indicating a cause-and-effect relationship.	thcy	113-117	V-set and immunoglobulin domain containing 2	Homo sapiens	83-86
19394322-4	2009	RESULTS: MTHFR 677T, MTRR 66A, GCPII 1561T, male gender, alcohol intake, smoking, diabetes, creatinine and hypertension were found to influence tHcy.	thcy	144-148	methylenetetrahydrofolate reductase	Homo sapiens	9-14
19394322-4	2009	RESULTS: MTHFR 677T, MTRR 66A, GCPII 1561T, male gender, alcohol intake, smoking, diabetes, creatinine and hypertension were found to influence tHcy.	thcy	144-148	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	21-25
19394322-4	2009	RESULTS: MTHFR 677T, MTRR 66A, GCPII 1561T, male gender, alcohol intake, smoking, diabetes, creatinine and hypertension were found to influence tHcy.	thcy	144-148	folate hydrolase 1	Homo sapiens	31-36
23105845-2	2009	Plasma total homocysteine (tHcy) is also influenced by genetic factors such as polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene.	thcy	27-31	methylenetetrahydrofolate reductase	Homo sapiens	100-135
23105845-2	2009	Plasma total homocysteine (tHcy) is also influenced by genetic factors such as polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene.	thcy	27-31	methylenetetrahydrofolate reductase	Homo sapiens	137-142
19372453-7	2009	The magnitude of tHcy reduction by B-vitamin treatment was consistent across ethnic groups (Chinese -3.8+/-4.5, Malay -4.9+/-4.2, and Indian -3.3+/-3.6 micromol/L) despite ethnic differences in MTHFR genotype and baseline folic acid (FA) and vitamin B(12) (vitB(12)) concentrations.	thcy	17-21	methylenetetrahydrofolate reductase	Homo sapiens	194-199
19219535-1	2009	BACKGROUND: The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD).	thcy	209-213	paraoxonase 1	Homo sapiens	151-164
19219535-1	2009	BACKGROUND: The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD).	thcy	209-213	paraoxonase 1	Homo sapiens	166-170
19219535-7	2009	PON1 55 and 192 genetic variants were significantly associated with PON1 activity, triglyceride, total cholesterol, tHcy and, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol in patients, respectively.	thcy	116-120	paraoxonase 1	Homo sapiens	0-4
19654594-4	2009	In addition, the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is an important determinant of elevated tHcy.	thcy	120-124	methylenetetrahydrofolate reductase	Homo sapiens	17-52
19654594-4	2009	In addition, the methylenetetrahydrofolate reductase (MTHFR) C677T gene variant is an important determinant of elevated tHcy.	thcy	120-124	methylenetetrahydrofolate reductase	Homo sapiens	54-59
19654594-5	2009	The main objective of the study was to examine the effect of changes in biological risk factors and lifestyle on tHcy in relation to MTHFR C677T genotype.	thcy	113-117	methylenetetrahydrofolate reductase	Homo sapiens	133-138
19285843-5	2009	Spearman rank correlation was used to analyse the relationship between the degree of methylation in ER-alpha gene and the level of tHcy.	thcy	131-135	estrogen receptor 1	Homo sapiens	100-108
19285843-10	2009	The spearman rank correlation analysis explored an obvious correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r=0.809, p<0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	139-143	estrogen receptor 1	Homo sapiens	108-116
19285843-10	2009	The spearman rank correlation analysis explored an obvious correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r=0.809, p<0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	273-277	estrogen receptor 1	Homo sapiens	108-116
19285843-13	2009	CONCLUSION: Hypermethylation of CpG islands in ER-alpha gene promoter region was found in much higher frequency in atherosclerosis patients, which is positively correlated with the increased level of plasma tHcy and the severity of atherosclerotic lesion, and the in vitro experimental results further extended above clinical data that HHcy can lead to the hypermethylation of ER-alpha gene, and hence to promote the occurrence and development of As.	thcy	207-211	estrogen receptor 1	Homo sapiens	47-55
19269283-2	2009	OBJECTIVES: We evaluated the relationship of tHcy and HTase with paraoxonase 1 (PON1) gene polymorphism according to CAD severity.	thcy	45-49	paraoxonase 1	Homo sapiens	65-78
19269283-2	2009	OBJECTIVES: We evaluated the relationship of tHcy and HTase with paraoxonase 1 (PON1) gene polymorphism according to CAD severity.	thcy	45-49	paraoxonase 1	Homo sapiens	80-84
19219535-1	2009	BACKGROUND: The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD).	thcy	209-213	methylenetetrahydrofolate reductase	Homo sapiens	140-145
19125845-7	2009	RESULTS: Patients exhibited significantly higher tHcy and lower folate levels than controls; hyper-tHcy was significantly associated with the variables group (patients vs. controls), MTHFR genotype, and their interaction terms.	thcy	99-103	methylenetetrahydrofolate reductase	Homo sapiens	183-188
18987302-1	2009	Untreated cystathionine beta-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy>200 microM), with thrombosis as the major cause of morbidity.	thcy	131-135	cystathionine beta-synthase	Homo sapiens	10-37
19153374-2	2009	Serum total homocysteine (tHcy) is a risk factor for small vessel disease and cognitive impairment and correlates with plasma Abeta levels.	thcy	26-30	amyloid beta precursor protein	Homo sapiens	126-131
19065546-12	2009	Vitamin B12 levels were significantly inversely associated with tHcy (r = - 0.263, p = 0.015) and marginally associated with PWV(r = - 0.212, p = 0.052).	thcy	64-68	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
19065546-15	2009	Additionally, vitamin B12 is significantly associated with tHcy concentrations and is identified as a marginally independent correlate of PWV in diabetic patients in the absence of folate deficiency.	thcy	59-63	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	22-25
19211833-1	2009	We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype.	thcy	220-224	methylenetetrahydrofolate reductase	Homo sapiens	242-277
19211833-1	2009	We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype.	thcy	220-224	methylenetetrahydrofolate reductase	Homo sapiens	279-284
19211833-9	2009	However, when creatinine was not in the model, the phosphatidylethanolamine N-methyltransferase 5465G-->A variant predicted lower tHcy (P < 0.001); an effect confined to the MTHFR 677TT genotype.	thcy	133-137	methylenetetrahydrofolate reductase	Homo sapiens	180-185
19211833-10	2009	Thus, in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma tHcy.	thcy	135-139	methylenetetrahydrofolate reductase	Homo sapiens	97-102
19797897-6	2009	People with high tHcy (the 3rd tertile) had more than twice as high a risk of developing AD than those with low tHcy, even after adjusting for age, sex, education, ApoE status, MMSE score and laboratory parameters.	thcy	17-21	apolipoprotein E	Homo sapiens	164-168
19454176-7	2009	Preeclamptic women bearing the mutated PON 192 RR and wild-type PON1 55 LL genotypes had higher tHcy levels than those of the healthy pregnants with the corresponding genotypes, supporting the possibility that the hyperhomocysteinaemia seen in preeclamptic women is associated with the PON genotypes.	thcy	96-100	paraoxonase 1	Homo sapiens	39-42
19454176-7	2009	Preeclamptic women bearing the mutated PON 192 RR and wild-type PON1 55 LL genotypes had higher tHcy levels than those of the healthy pregnants with the corresponding genotypes, supporting the possibility that the hyperhomocysteinaemia seen in preeclamptic women is associated with the PON genotypes.	thcy	96-100	paraoxonase 1	Homo sapiens	64-68
19454176-7	2009	Preeclamptic women bearing the mutated PON 192 RR and wild-type PON1 55 LL genotypes had higher tHcy levels than those of the healthy pregnants with the corresponding genotypes, supporting the possibility that the hyperhomocysteinaemia seen in preeclamptic women is associated with the PON genotypes.	thcy	96-100	paraoxonase 1	Homo sapiens	64-67
19056652-2	2009	Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene.	thcy	51-55	methylenetetrahydrofolate reductase	Homo sapiens	127-162
19056652-2	2009	Major factors affecting plasma total homocysteine (tHcy) concentrations include folate concentrations and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene.	thcy	51-55	methylenetetrahydrofolate reductase	Homo sapiens	164-169
19056652-5	2009	MTHFR 677TT homozygotes had higher (P < 0.01) tHcy concentrations both before and after fortification compared with MTHFR 677CC homozygotes.	thcy	49-53	methylenetetrahydrofolate reductase	Homo sapiens	0-5
18823966-5	2008	RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG.	thcy	18-22	methylenetetrahydrofolate reductase	Homo sapiens	52-57
18823966-5	2008	RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG.	thcy	18-22	folate hydrolase 1	Homo sapiens	68-73
18823966-5	2008	RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG.	thcy	18-22	methylenetetrahydrofolate reductase	Homo sapiens	121-126
18823966-5	2008	RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG.	thcy	18-22	folate hydrolase 1	Homo sapiens	133-138
18823966-5	2008	RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG.	thcy	18-22	methylenetetrahydrofolate reductase	Homo sapiens	121-126
18823966-5	2008	RESULTS: Maternal tHcy was affected individually by MTHFR C677T and GCPII C1561T polymorphisms and by combined genotypes MTHFR 677TT/GCPII 1561CC and MTHFR 677TT/RFC1 80AG.	thcy	18-22	replication factor C subunit 1	Homo sapiens	162-166
18823966-7	2008	Neonatal tHcy was predicted directly by maternal tHcy and inversely by maternal SF, neonatal Cbl and neonatal RFC1 80G allele (AG+GG genotypes).	thcy	9-13	replication factor C subunit 1	Homo sapiens	110-114
18823966-10	2008	CONCLUSIONS: Maternal tHcy was affected by MTHFR C677T, RFC1 A80G and GCPII C1561T polymorphisms.	thcy	22-26	methylenetetrahydrofolate reductase	Homo sapiens	43-48
18823966-10	2008	CONCLUSIONS: Maternal tHcy was affected by MTHFR C677T, RFC1 A80G and GCPII C1561T polymorphisms.	thcy	22-26	replication factor C subunit 1	Homo sapiens	56-60
18823966-10	2008	CONCLUSIONS: Maternal tHcy was affected by MTHFR C677T, RFC1 A80G and GCPII C1561T polymorphisms.	thcy	22-26	folate hydrolase 1	Homo sapiens	70-75
18823966-12	2008	Neonatal RFC1 A80G polymorphism influenced tHcy in neonates.	thcy	43-47	replication factor C subunit 1	Homo sapiens	9-13
18981340-9	2008	The tHcy was 0.19 mg/L higher among participants with the MTHFR C677T TT genotype compared with the CC genotype.	thcy	4-8	methylenetetrahydrofolate reductase	Homo sapiens	58-63
18981340-11	2008	CONCLUSIONS: The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%.	thcy	68-72	methylenetetrahydrofolate reductase	Homo sapiens	52-57
18981340-11	2008	CONCLUSIONS: The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%.	thcy	127-131	methylenetetrahydrofolate reductase	Homo sapiens	52-57
18981340-11	2008	CONCLUSIONS: The triangular association between the MTHFR genotype, tHcy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHcy by 0.19 mg/L could reduce the odds of depression by about 20%.	thcy	127-131	methylenetetrahydrofolate reductase	Homo sapiens	52-57
18620331-10	2008	CONCLUSION: MTHFR TT and MS GG genotypes increase tHcy concentration and coronary stenosis risk, especially with low folatemia.	thcy	50-54	methylenetetrahydrofolate reductase	Homo sapiens	12-17
18790817-3	2008	To assess the effect on tHcy according to methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype.	thcy	24-28	methylenetetrahydrofolate reductase	Homo sapiens	42-77
18790817-3	2008	To assess the effect on tHcy according to methylenetetrahydrofolate reductase (MTHFR) 677C>T genotype.	thcy	24-28	methylenetetrahydrofolate reductase	Homo sapiens	79-84
18236055-7	2008	In GDM women serum tHcy correlated with vitamin B(12) (r= -0.47, P<0.01) and folates (r= -0.51, P<0.001); in CG women with HOMA-IR, a marker of insulin resistance (r= -0.49, P<0.05).	thcy	19-23	insulin	Homo sapiens	150-157
18236055-10	2008	The results suggest the importance of the B-group vitamins in regulation of serum tHcy levels in women with insulin resistance/gestational diabetes, what might be relevant in protection against pregnancy complications associated with elevated tHcy in GDM women.	thcy	82-86	insulin	Homo sapiens	108-115
18855261-1	2008	UNLABELLED: The substitution of cytosine (C) by thymine (T) at nucleotide 677 of the methylenetetrahydrofolate reductase (MTHFR) gene, which converts an alanine to a valine residue, is a frequent polymorphism with reduced specific activity, associated with moderate increase in plasma homocysteine levels (tHcy) and risk of vascular diseases.	thcy	306-310	methylenetetrahydrofolate reductase	Homo sapiens	85-120
18855261-1	2008	UNLABELLED: The substitution of cytosine (C) by thymine (T) at nucleotide 677 of the methylenetetrahydrofolate reductase (MTHFR) gene, which converts an alanine to a valine residue, is a frequent polymorphism with reduced specific activity, associated with moderate increase in plasma homocysteine levels (tHcy) and risk of vascular diseases.	thcy	306-310	methylenetetrahydrofolate reductase	Homo sapiens	122-127
18189241-2	2008	We investigated whether functional polymorphisms in catechol-O-methyltransferase (COMT) influence tHcy, since COMT activity produces S-adenosylhomocysteine (SAH), a homocysteine precursor.	thcy	98-102	catechol-O-methyltransferase	Homo sapiens	52-80
18189241-2	2008	We investigated whether functional polymorphisms in catechol-O-methyltransferase (COMT) influence tHcy, since COMT activity produces S-adenosylhomocysteine (SAH), a homocysteine precursor.	thcy	98-102	catechol-O-methyltransferase	Homo sapiens	82-86
18189241-3	2008	We hypothesized that high activity COMT variants would be associated with high tHcy, since they presumably result in increased formation of SAH.	thcy	79-83	catechol-O-methyltransferase	Homo sapiens	35-39
18189241-5	2008	As predicted, COMT Val(158) carriers had significantly higher tHcy than Met(158) homozygotes.	thcy	62-66	catechol-O-methyltransferase	Homo sapiens	14-18
18189241-7	2008	In addition, individuals homozygous for the COMT G(-287) allele tended to have lower tHcy levels.	thcy	85-89	catechol-O-methyltransferase	Homo sapiens	44-48
18189241-8	2008	High activity variants of COMT interact with the low activity variant of MTHFR to increase tHcy levels.	thcy	91-95	catechol-O-methyltransferase	Homo sapiens	26-30
18189241-8	2008	High activity variants of COMT interact with the low activity variant of MTHFR to increase tHcy levels.	thcy	91-95	methylenetetrahydrofolate reductase	Homo sapiens	73-78
18070950-9	2008	Higher tHcy and lower folate concentrations correlated with impaired Delta RI(ALB) and increased CIMT.	thcy	7-11	albumin	Homo sapiens	69-82
18070950-9	2008	Higher tHcy and lower folate concentrations correlated with impaired Delta RI(ALB) and increased CIMT.	thcy	7-11	CIMT	Homo sapiens	97-101
18683819-6	2008	The effect of folate, PLP and vitamin B-12 concentrations on plasma tHcy correlated with Se concentration at baseline.	thcy	68-72	pyridoxal phosphatase	Homo sapiens	22-25
18189241-9	2008	The effect on tHcy may contribute to the reported associations of COMT genotype with psychiatric and neurobiological phenotypes.	thcy	14-18	catechol-O-methyltransferase	Homo sapiens	66-70
18558298-10	2008	In addition, tHcy level was positively correlated with albumin and creatinine, and was negatively correlated with C-reactive protein, MIS, and comorbidity.	thcy	13-17	C-reactive protein	Homo sapiens	114-132
18093792-8	2008	In the group of hypertensive patients, a strong positive correlation between tHcy and TNF-alpha was observed (r=0.48; p<0.001).	thcy	77-81	tumor necrosis factor	Homo sapiens	86-95
18093792-10	2008	In multivariate regression analysis tHcy, but not lipids, was an independent predictor of TNF-alpha.	thcy	36-40	tumor necrosis factor	Homo sapiens	90-99
18093792-11	2008	In conclusion, our findings show that plasma tHcy is a determinant of TNF-alpha in hypertension and that obesity or a history of vascular events aggravates inflammation in patients with hypertension.	thcy	45-49	tumor necrosis factor	Homo sapiens	70-79
17522601-5	2008	RESULTS: Serum folate, MTHFR 677T allele and MTR 2756AA genotypes were the predictors of tHcy levels in pregnant women.	thcy	89-93	methylenetetrahydrofolate reductase	Homo sapiens	23-28
17522601-11	2008	CONCLUSIONS: Serum folate and MTHFR C677T and MTR A2576G gene polymorphisms were the determinants for tHcy levels.	thcy	102-106	methylenetetrahydrofolate reductase	Homo sapiens	30-35
17522601-12	2008	The interaction between low levels of serum Cbl and MTHFR (C677T or A1298C) or MTRR A66G gene polymorphisms was associated with increased tHcy.	thcy	138-142	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	79-83
18774994-8	2008	The MTRR 66GG and MTHFR 1298 CC genotypes may confer protection against early nephropathy, possibly because they are associated with lower tHcy.	thcy	139-143	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	4-8
18774994-8	2008	The MTRR 66GG and MTHFR 1298 CC genotypes may confer protection against early nephropathy, possibly because they are associated with lower tHcy.	thcy	139-143	methylenetetrahydrofolate reductase	Homo sapiens	18-23
18646531-1	2008	OBJECTIVE: To investigate the methylation status in promoter region of ER-alpha gene and the relationship beteen the degree of methylation in ER-alpha gene and the level of total plasma homocysteine(tHcy) in atherosclerosis patients.	thcy	199-203	estrogen receptor 1	Homo sapiens	71-79
19326344-8	2008	Homocysteine (tHcy) was significantly negatively associated with serum folate, serum vitamin B12, and fruit and vegetable intake, and also depended on the MTHFR 677C>T genotype.	thcy	14-18	methylenetetrahydrofolate reductase	Homo sapiens	155-160
18513846-7	2008	Genotypes of c.1298A>C and c.677C>T were correlated with tHcy, folate and B12.	thcy	63-67	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	80-83
18356552-3	2008	The strong linear relationship between tHcy and cystatin C was not altered by long-term B-vitamin treatment.	thcy	39-43	cystatin C	Homo sapiens	48-58
18356552-6	2008	CONCLUSIONS: Adjusting for renal function eliminates the relationship between tHcy and CIMT and FMD, supporting the hypothesis that elevated tHcy is a marker for renal impairment rather than an independent cardiovascular risk factor.	thcy	78-82	CIMT	Homo sapiens	87-91
18356552-6	2008	CONCLUSIONS: Adjusting for renal function eliminates the relationship between tHcy and CIMT and FMD, supporting the hypothesis that elevated tHcy is a marker for renal impairment rather than an independent cardiovascular risk factor.	thcy	141-145	CIMT	Homo sapiens	87-91
18838525-10	2008	On the contrary, oxLDL was the main predictor of ET-1 (p = 0.008), suggesting that tHcy may increase ET-1 by enhancing the production of oxLDL.	thcy	83-87	endothelin 1	Homo sapiens	49-53
18838525-10	2008	On the contrary, oxLDL was the main predictor of ET-1 (p = 0.008), suggesting that tHcy may increase ET-1 by enhancing the production of oxLDL.	thcy	83-87	endothelin 1	Homo sapiens	101-105
18591889-10	2008	Our data show that menopause has a strong influence on tHcy concentration even in Type 2 diabetic women and demonstrate, for the first time, that it may modulate the association between tHcy and the common MTHFR polymorphism both in diabetic and non-diabetic women.	thcy	55-59	methylenetetrahydrofolate reductase	Homo sapiens	206-211
18591889-10	2008	Our data show that menopause has a strong influence on tHcy concentration even in Type 2 diabetic women and demonstrate, for the first time, that it may modulate the association between tHcy and the common MTHFR polymorphism both in diabetic and non-diabetic women.	thcy	186-190	methylenetetrahydrofolate reductase	Homo sapiens	206-211
18412997-5	2008	The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy.	thcy	42-46	methylenetetrahydrofolate reductase	Homo sapiens	104-139
18412997-5	2008	The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy.	thcy	42-46	methylenetetrahydrofolate reductase	Homo sapiens	141-146
18412997-5	2008	The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy.	thcy	171-175	methylenetetrahydrofolate reductase	Homo sapiens	104-139
18412997-5	2008	The most important genetic determinant of tHcy in the general population is the common C677T variant in methylenetetrahydrofolate reductase (MTHFR) that results in higher tHcy.	thcy	171-175	methylenetetrahydrofolate reductase	Homo sapiens	141-146
18646531-9	2008	The spearman rank correlation analysis explored an obviously correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r = 0.809, P < 0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	279-283	estrogen receptor 1	Homo sapiens	110-118
18646531-10	2008	CONCLUSION: Hyermethylation of CpG islands in ER-alpha gene promoter region was found in high frequency in atherosclerosis patients, which is positive correlated with the increased level of plasma tHcy and the severity of atherosclerotic lesion.	thcy	197-201	estrogen receptor 1	Homo sapiens	46-54
18646531-1	2008	OBJECTIVE: To investigate the methylation status in promoter region of ER-alpha gene and the relationship beteen the degree of methylation in ER-alpha gene and the level of total plasma homocysteine(tHcy) in atherosclerosis patients.	thcy	199-203	estrogen receptor 1	Homo sapiens	142-150
18646531-5	2008	Using spearman rank correlation to analyse the relatinship between the degree of methylation in ER-alpha gene and the level of tHcy.	thcy	127-131	estrogen receptor 1	Homo sapiens	96-104
18646531-9	2008	The spearman rank correlation analysis explored an obviously correlation between the degree of methylation in ER-alpha gene and the level of tHcy (r = 0.809, P < 0.05), and the severity of atherosclerotic lesion was also heightened along with the increment of plasma level of tHcy.	thcy	141-145	estrogen receptor 1	Homo sapiens	110-118
18325185-10	2008	SOD and GPx activities were negatively correlated with tHcy concentration (P < 0.05, P < 0.001, respectively).	thcy	55-59	superoxide dismutase 1	Homo sapiens	0-3
17433477-8	2008	When circulating tHcy levels were treated as a continuous variable, they were significantly associated with late cardiovascular death (p<0.001 for both cohorts) by univariate Cox regression analysis, but not by multivariate Cox regression analysis (p=0.8, and p=1 for STEMI and NSTE-ACS cohorts, respectively).	thcy	17-21	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	286-289
18194083-8	2008	In univariate analysis, plasma tHcy level correlated significantly with serum vitamin B12 level, serum folic acid level, WHR, estimated creatinine clearance, aspirin use and fibrate use.	thcy	31-35	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	86-89
18800176-6	2008	Plasma concentration of tHcy in CC and CT genotypes of MTHFR C677T was significantly increased in patients with OAD and in patients with DVT.	thcy	24-28	methylenetetrahydrofolate reductase	Homo sapiens	55-60
18800176-7	2008	Plasma concentration of tHcy in AC genotype of MTHFR A1298C was increased in patients with OAD and in patients with DVT.	thcy	24-28	methylenetetrahydrofolate reductase	Homo sapiens	47-52
18800176-11	2008	We conclude that MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with OAD and DVT.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	17-22
18800176-11	2008	We conclude that MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with OAD and DVT.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	33-38
17822659-13	2007	Our finding supports an important role of the MTHFR gene in CAD and provides evidence of polygenic regulation of tHcy.	thcy	113-117	methylenetetrahydrofolate reductase	Homo sapiens	46-51
18844488-3	2008	Functional genetic variants of the MS may alter tHcy as well as folate levels which are independent risk factors for CAD.	thcy	48-52	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	35-37
18844488-4	2008	The influence of a common genetic polymorphism 2756A>G of the MS gene (MTR) on plasma tHcy, folate and vitamin B(12) levels and its relation to the risk of myocardial infarction (MI) in a Tunisian case-control study was investigated.	thcy	89-93	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	65-67
18064318-4	2007	We hypothesized that COMT dysfunction by virtue of functional genetic polymorphisms may affect plasma total homocysteine (tHcy).	thcy	122-126	catechol-O-methyltransferase	Homo sapiens	21-25
18064318-5	2007	Our primary objective was to study the association between common COMT polymorphisms and tHcy.	thcy	89-93	catechol-O-methyltransferase	Homo sapiens	66-70
18064318-13	2007	We show that the COMT rs4680 variant modulates tHcy, and might be associated with venous thrombosis risk as well.	thcy	47-51	catechol-O-methyltransferase	Homo sapiens	17-21
17822368-3	2007	Glutathione peroxidase-1 (GPx-1), a selenocysteine-containing antioxidant enzyme, may be a key target of Hcy"s deleterious actions, and several experimental and clinical studies have demonstrated a complex relationship between plasma total homocysteine (tHcy), GPx-1, and endothelial dysfunction.	thcy	254-258	glutathione peroxidase 1	Homo sapiens	0-24
17822368-3	2007	Glutathione peroxidase-1 (GPx-1), a selenocysteine-containing antioxidant enzyme, may be a key target of Hcy"s deleterious actions, and several experimental and clinical studies have demonstrated a complex relationship between plasma total homocysteine (tHcy), GPx-1, and endothelial dysfunction.	thcy	254-258	glutathione peroxidase 1	Homo sapiens	26-32
17822368-3	2007	Glutathione peroxidase-1 (GPx-1), a selenocysteine-containing antioxidant enzyme, may be a key target of Hcy"s deleterious actions, and several experimental and clinical studies have demonstrated a complex relationship between plasma total homocysteine (tHcy), GPx-1, and endothelial dysfunction.	thcy	254-258	glutathione peroxidase 1	Homo sapiens	26-31
19996639-5	2008	We have also investigated the relationship between tHcy levels and the presence of MTHFR C677T gene polymorphism.	thcy	51-55	methylenetetrahydrofolate reductase	Homo sapiens	83-88
19996639-12	2008	CONCLUSIONS: Type 2 diabetics who are homozygous or heterozygous for the MTHFR C677T gene polymorphism showed normal tHcy levels.	thcy	117-121	methylenetetrahydrofolate reductase	Homo sapiens	73-78
17597801-2	2007	The aim of this study is to investigate the association of plasma tHcy with functional and structural changes in the large arteries by measuring aortic pulse-wave velocity (PWV) and carotid artery intima-media thickness (CIMT).	thcy	66-70	CIMT	Homo sapiens	221-225
17597801-9	2007	Furthermore, in the univariate model, CIMT increased significantly with increasing tHcy concentration; CIMT increased by 0.19 mm (95% CI 0.11; 0.26) per unit increase log tHcy.	thcy	83-87	CIMT	Homo sapiens	38-42
17597801-9	2007	Furthermore, in the univariate model, CIMT increased significantly with increasing tHcy concentration; CIMT increased by 0.19 mm (95% CI 0.11; 0.26) per unit increase log tHcy.	thcy	83-87	CIMT	Homo sapiens	103-107
17597801-9	2007	Furthermore, in the univariate model, CIMT increased significantly with increasing tHcy concentration; CIMT increased by 0.19 mm (95% CI 0.11; 0.26) per unit increase log tHcy.	thcy	171-175	CIMT	Homo sapiens	38-42
17597801-9	2007	Furthermore, in the univariate model, CIMT increased significantly with increasing tHcy concentration; CIMT increased by 0.19 mm (95% CI 0.11; 0.26) per unit increase log tHcy.	thcy	171-175	CIMT	Homo sapiens	103-107
17561949-1	2007	The influence of antiepileptic drugs (AEDs) and/or common polymorphisms (677C --> T, 1298A --> C) of the methylene-tetrahydrofolate-reductase (MTHFR) gene on the recurrence time of hyper-total-homocysteinemia (tHcy > 13 micromol/L) was investigated in 59 hyper-homocysteinemic patients (34M/25F, 20-49 years).	thcy	216-220	methylenetetrahydrofolate reductase	Homo sapiens	111-147
17561949-3	2007	Four MTHFR polymorphism groups were identified with the following tHcy (micromol/L) and folate (nmol/L) levels (mean +/- SD): (a) MTHFR677TT/1298AA, 24 patients, 36.0 +/- 4.8, 4.1 +/- 0.7; (b) MTHFR677CT/1298AC 27.1 +/- 2.7, 5.3 +/- 1.0 (n = 15); (c) MTHFR677CT/1298AA 16.6 +/- 3.6, 6.8 +/- 1.0 (n = 11), all taking enzyme-inducing AEDs; and (d) MTHFR677TT/1298AA 24.5 +/- 3.2, 5.6 +/- 1.1 (n = 9), treated with new AEDs.	thcy	66-70	methylenetetrahydrofolate reductase	Homo sapiens	5-10
17618615-3	2007	OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications.	thcy	49-53	methylenetetrahydrofolate reductase	Homo sapiens	65-100
17884450-2	2007	We tested the hypothesis that tHcy correlates with aortic stiffness and insulin resistance in type 2 diabetic patients.	thcy	30-34	insulin	Homo sapiens	72-79
17884450-10	2007	In conclusion, our results indicate that the elevated level of tHcy in Japanese patients with type 2 diabetes mellitus is characterized by increased aortic stiffness and insulin resistance, and that the BaPWV and the HOMA index are independent predictors of tHcy.	thcy	63-67	insulin	Homo sapiens	170-177
17618615-3	2007	OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications.	thcy	49-53	methylenetetrahydrofolate reductase	Homo sapiens	102-107
17618615-6	2007	Homozygosity for the T allele of MTHFR was more frequent in diabetics than in healthy subjects (12.8% vs. 7.2%) and it was associated with higher tHcy levels.	thcy	146-150	methylenetetrahydrofolate reductase	Homo sapiens	33-38
17761368-9	2007	tHcy showed significant correlations with hs-CRP (rs = 0.35; P = 0.003) and low-density lipoprotein-cholesterol (LDL-C; rs = 0.49; P = 0.005).	thcy	0-4	C-reactive protein	Homo sapiens	45-48
17436311-7	2007	We confirmed the strong associations of MTHFR c.665C>T with tHcy and folate, but also observed significant (P<0.01) changes in metabolite concentrations according to other gene polymorphisms.	thcy	63-67	methylenetetrahydrofolate reductase	Homo sapiens	40-45
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	59-62
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	59-62
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	59-62
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17761368-12	2007	These data support 4 main conclusions: (1) Elevation of hs-CRP and tHcy are common in CVD; (2) the significant relationship between tHcy and hs-CRP suggests that the association of tHcy with CVD risk may be dependent on inflammation-related mechanisms; (3) increased hs-CRP and tHcy show that patients with CVD may be at greater risk of subsequent coronary heart disease; and (4) admission hs-CRP could be used as an indicator of prognosis.	thcy	132-136	C-reactive protein	Homo sapiens	144-147
17537983-5	2007	The higher renal CBS activity in males (22.7 +/- 3.1 mmol cystathionine.h(-1).kg kidney(-1)) vs. females (8.4 +/- 3.4 mmol cystathionine.h(-1).kg kidney(-1), P < or = 10(-6)) in C57Bl/6J mice was associated with lower plasma tHcy levels in males vs. females, and this difference was exacerbated in Cbs+/- mice (7.7 +/- 1.9 micromol/l in males vs. 13.8 +/- 6.4 micromol/l in females, P = 0.005).	thcy	228-232	cystathionine beta-synthase	Mus musculus	17-20
17612379-12	2007	Either plasma folate or vitamin B12 were shown as strong predictors of tHcy.	thcy	71-75	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	32-35
17537983-4	2007	Renal function is known to be an important determinant of tHcy, and, in this study, we demonstrate that renal CBS expression and activity in mice diminished approximately twofold after castration, whereas ovariectomization was without effect.	thcy	58-62	cystathionine beta-synthase	Mus musculus	110-113
17384003-12	2007	Lowering tHcy and SAH might protect the brain by preventing P-tau accumulation.	thcy	9-13	microtubule associated protein tau	Homo sapiens	62-65
17436239-5	2007	The MTHFR 677C-->T polymorphism, folate, riboflavin, cobalamin, and vitamin B6 were independent predictors of tHcy in multivariate models (P<.001), and genotype effects were strongest when B vitamins were low (P<or=.006).	thcy	113-117	methylenetetrahydrofolate reductase	Homo sapiens	4-9
17436239-6	2007	Conversely, the MTHFR polymorphism influenced B vitamin effects, which were strongest in the TT group, in which the estimated tHcy difference between subjects with vitamin concentrations in the lowest compared with the highest quartile was 5.4 micromol/liter for folate, 4.1 micromol/liter for riboflavin, 3.2 micromol/liter for cobalamin, and 2.1 micromol/liter for vitamin B6.	thcy	126-130	methylenetetrahydrofolate reductase	Homo sapiens	16-21
17295607-13	2007	The association between tHcy and risk of hip fracture was only slightly weakened by adjustments for plasma levels of vitamin B12 and folate.	thcy	24-28	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	125-128
17684227-2	2007	Previous studies provided conflicting results on the effect of the GCPII 1561C-->T polymorphism on folate and total homocysteine (tHcy) concentrations.	thcy	133-137	folate hydrolase 1	Homo sapiens	67-72
17684227-3	2007	OBJECTIVE: We aimed to determine the potential effects of 2 polymorphisms of GCPII on plasma folate and tHcy concentrations, cognition, anxiety, and depression in a large aging cohort of Norwegians enrolled in the Hordaland Homocysteine Study.	thcy	104-108	folate hydrolase 1	Homo sapiens	77-82
17611986-1	2007	OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.	thcy	323-327	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	77-106
17611986-1	2007	OBJECTIVE: To investigate the distribution of the A2756G polymorphism of the methionine synthase reductase (MTR) gene in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX) compared with a healthy control group; and to examine the relationships among the A2756G polymorphism, plasma total homocysteine (tHcy), serum folate and vitamin B12 levels, disease activity, and MTX toxicity in patients with RA.	thcy	323-327	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	108-111
17334642-3	2007	The MTHFR 677C>T polymorphism was associated with increased tHcy concentrations in both the children and the adolescents (P<0.001 for both age groups) in both genders.	thcy	63-67	methylenetetrahydrofolate reductase	Homo sapiens	4-9
17438114-8	2007	CONCLUSIONS: The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis.	thcy	75-79	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-50
17438114-8	2007	CONCLUSIONS: The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis.	thcy	243-247	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	45-50
17461517-9	2007	CONCLUSION: The results of the present study demonstrate that the MTR 2756A > G and MTHFR 677C > T polymorphisms interact with elevated total homocysteine (tHcy) levels, leading to an increased risk of ischemic stroke.	thcy	162-166	methylenetetrahydrofolate reductase	Homo sapiens	87-92
17334642-4	2007	The effect of MTHFR 1298A>C was studied separately in subjects with the 677CC and 677CT genotypes, and the 1298C allele was found to be associated with higher tHcy levels both when children were stratified according to 677C>T genotypes, and when using haplotype analyses and diplotype reconstructions.	thcy	162-166	methylenetetrahydrofolate reductase	Homo sapiens	14-19
17334642-8	2007	The major genetic impact on tHcy concentrations is attributable to the MTHFR 677C>T polymorphism.	thcy	28-32	methylenetetrahydrofolate reductase	Homo sapiens	71-76
18097138-7	2007	tHcy correlated positively with cystatin C, but negatively with vitamin B(12) and folic acid.	thcy	0-4	cystatin C	Homo sapiens	32-42
17264883-9	2007	CONCLUSIONS: This prospective cohort study suggests that the functional COMT Val158Met polymorphism is associated with increased risk of acute coronary events and it may interact with high serum tHcy levels.	thcy	195-199	catechol-O-methyltransferase	Homo sapiens	72-76
18097138-9	2007	In multivariate analysis, folic acid and cystatin C remained significant predictors of tHcy (adjusted R(2) = 60.6%).	thcy	87-91	cystatin C	Homo sapiens	41-51
18097138-12	2007	Cystatin C and folic acid explain most of the tHcy variance.	thcy	46-50	cystatin C	Homo sapiens	0-10
17215186-8	2007	Vitamin B12 supplementation increased plasma vitamin B12 concentration (125 to 215 pmol/L, p <0.05) and reduced tHcy concentration (18.0 to 13.0 micromol/L, p <0.05) within first 2 weeks, both of which remained stable for the next 4 weeks.	thcy	115-119	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
17215186-12	2007	High-dose per oral vitamin B12 supplementation significantly reduced plasma tHcy within 2 weeks but did not achieve normal plasma tHcy concentration even after 6 weeks.	thcy	76-80	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	27-30
16896659-7	2007	The fasting plasma insulin concentrations (p<0.0001) and the homeostasis model assessment (HOMA) index values (p<0.0001) were higher in the high tHcy group than in the normal tHcy group.	thcy	151-155	insulin	Homo sapiens	19-26
16896659-9	2007	CONCLUSION: Our results demonstrate that high levels of tHcy are associated with depressed cardiovascular autonomic function and insulin resistance in patients with type 2 diabetes mellitus.	thcy	56-60	insulin	Homo sapiens	129-136
17342693-2	2007	The aims of the present study were to explore the effect of alternate vitamin supplementation with folic acid or vitamin B 12 on tHcy concentrations in haemodialysis (HD) patients, and to compare changes in tHcy concentrations with MTHFR genotype.	thcy	207-211	methylenetetrahydrofolate reductase	Homo sapiens	232-237
17222169-8	2007	Cystatin C was correlated with tHcy (r = 0.45, P < 0.001) and with MMA (r =0.28, P < 0.001), independently of vitamin B(12)- and folate status.	thcy	31-35	cystatin C	Homo sapiens	0-10
17222169-9	2007	According to multiple regression, independent predictors for tHcy were plasma folate (15%), cystatin C (11%) and vitamin B(12) (4%), and for MMA, cystatin C (8%) and vitamin B(12) (2%).	thcy	61-65	cystatin C	Homo sapiens	92-102
17222169-11	2007	Nomograms for evaluation of tHcy and MMA in relation to both cystatin C and serum creatinine are presented.	thcy	28-32	cystatin C	Homo sapiens	61-71
16908053-8	2007	A suppression effect may explain the non-significant total MTHFR-IHD relation (OR=1.275, 95% CI: 1.02 to 1.71 for the indirect MTHFR-tHcy-IHD path; OR=0.52, 95% CI: 0.17 to 1.64 for the direct MTHFR-IHD path).	thcy	133-137	methylenetetrahydrofolate reductase	Homo sapiens	127-132
17497026-15	2007	Our data suggest that HHcy is strongly and independently associated to CAD risk increase; and MTHFR C677T polymorphism and smoking habits were the main predictors of tHcy levels.	thcy	166-170	methylenetetrahydrofolate reductase	Homo sapiens	94-99
16908053-8	2007	A suppression effect may explain the non-significant total MTHFR-IHD relation (OR=1.275, 95% CI: 1.02 to 1.71 for the indirect MTHFR-tHcy-IHD path; OR=0.52, 95% CI: 0.17 to 1.64 for the direct MTHFR-IHD path).	thcy	133-137	methylenetetrahydrofolate reductase	Homo sapiens	127-132
17111197-10	2006	Patients with MTHFR C677T and MTHFR A1298C gene mutations had a similar mean tHcy levels with controls.	thcy	77-81	methylenetetrahydrofolate reductase	Homo sapiens	14-19
17158432-5	2006	OBJECTIVE: We investigated in an elderly population whether 1) APOE4 is associated with hyperhomocysteinemia [plasma total homocysteine (tHcy) > 15 micromol/L], 2) hyperhomocysteinemia affects the association between APOE4 and high CRP (serum CRP > 3 mg/L), and 3) B vitamin status affects these associations.	thcy	137-141	apolipoprotein E	Homo sapiens	63-68
17111197-10	2006	Patients with MTHFR C677T and MTHFR A1298C gene mutations had a similar mean tHcy levels with controls.	thcy	77-81	methylenetetrahydrofolate reductase	Homo sapiens	30-35
16533539-5	2006	However, DS patients with the MTHFR TT genotype showed an increased of plasma homocysteine (tHcy).	thcy	92-96	methylenetetrahydrofolate reductase	Homo sapiens	30-35
17065574-4	2006	THcy was higher but within normal ranges in MTHFR 677TT homozygotes (10.6%) and carriers of the MTHFR 1793A allele (8%).	thcy	0-4	methylenetetrahydrofolate reductase	Homo sapiens	44-49
17065574-4	2006	THcy was higher but within normal ranges in MTHFR 677TT homozygotes (10.6%) and carriers of the MTHFR 1793A allele (8%).	thcy	0-4	methylenetetrahydrofolate reductase	Homo sapiens	96-101
16524711-5	2006	Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR 677 TT genotype relative to the CC genotype.	thcy	83-87	methylenetetrahydrofolate reductase	Homo sapiens	126-131
16968465-7	2006	Folate and vitamin B12 concentrations, estimated glomerular filtration rate (GFR), MTHFR 677C > T polymorphism were the major determinants of tHcy in this population.	thcy	145-149	methylenetetrahydrofolate reductase	Homo sapiens	83-88
16959233-4	2006	tHcy level increased with age, was significantly higher in men than in women, and exhibited inverse correlations with folate and vitamin B12.	thcy	0-4	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	137-140
16791140-2	2006	Recently, we described the association of a 31 bp variable number of tandem repeats (VNTR) in the cystathionine beta-synthase (CBS) gene with both CBS enzyme activity and tHcy concentrations.	thcy	171-175	cystathionine beta-synthase	Homo sapiens	98-125
16690175-9	2006	Age, BMI, waist circumference (WC), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were positively correlated with tHcy, whereas serum folate and vitamin B12 were negatively correlated.	thcy	133-137	D-box binding PAR bZIP transcription factor	Homo sapiens	96-99
16690175-14	2006	Children with tHcy levels above the upper reference limits (>10 micromol/L) were found to be correlated with BMI, WC, SBP, serum folate and vitamin B12 levels.	thcy	14-18	selenium binding protein 1	Homo sapiens	121-124
16690175-14	2006	Children with tHcy levels above the upper reference limits (>10 micromol/L) were found to be correlated with BMI, WC, SBP, serum folate and vitamin B12 levels.	thcy	14-18	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	151-154
16791140-2	2006	Recently, we described the association of a 31 bp variable number of tandem repeats (VNTR) in the cystathionine beta-synthase (CBS) gene with both CBS enzyme activity and tHcy concentrations.	thcy	171-175	cystathionine beta-synthase	Homo sapiens	127-130
16706975-3	2006	Extensive candidate gene studies have identified several genetic variants, including the MTHFR 677C>T, that influence tHcy levels, but so far only part of the genetic variation in tHcy can be explained.	thcy	121-125	methylenetetrahydrofolate reductase	Homo sapiens	89-94
16868263-3	2006	Employing a cross-sectional design and multiple regression analyses, fasting concentrations of tHcy and its vitamin cofactors (folate, B6, and B12) were related to multiple domains of cognitive performance.	thcy	95-99	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	135-146
16917147-5	2006	In light of these data and the growing parallel interest in plasma tHcy as an emerging vascular risk factor there was considerable hope that vitamin therapy with folate, B12 and B6, shown to lower plasma tHcy levels, could significantly reduce the risk of stroke and dementia permitting healthy brain aging.	thcy	67-71	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	170-180
16917147-5	2006	In light of these data and the growing parallel interest in plasma tHcy as an emerging vascular risk factor there was considerable hope that vitamin therapy with folate, B12 and B6, shown to lower plasma tHcy levels, could significantly reduce the risk of stroke and dementia permitting healthy brain aging.	thcy	204-208	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	170-180
16401615-5	2006	Plasma tHcy levels were positively correlated with disease duration and C-reactive protein CRP levels and negatively correlated with disease onset age.	thcy	7-11	C-reactive protein	Homo sapiens	91-94
16574890-5	2006	In a regression model, including age and fibrinogen, plasma tHcy was an independent predictor of clot permeation and fibrinolysis time in healthy subjects (R2=0.88, P<0.0001 and R2=0.54, P<0.0001, respectively).	thcy	60-64	fibrinogen beta chain	Homo sapiens	41-51
16574890-6	2006	In CAD patients, tHcy and fibrinogen were stronger predictors of the permeation coefficient (R2=0.84; P<0.0001) than was fibrinogen alone (R2=0.66; P<0.0001), whereas tHcy was the only predictor of lysis time (R2=0.69; P<0.0001).	thcy	173-177	fibrinogen beta chain	Homo sapiens	26-36
16758261-9	2006	CONCLUSION: Our prospective trial shows, that COMT inhibition with tolcapone lowers tHcy synthesis.	thcy	84-88	catechol-O-methyltransferase	Homo sapiens	46-50
16702348-5	2006	Increasing age, male sex, smoking, coffee consumption, high blood pressure, unfavorable lipid profile, high creatinine, and the MTHFR 677C > T polymorphism are among the factors associated with increased tHcy levels; physical activity, moderate alcohol consumption, and a good folate or vitamin B-12 status are associated with lower tHcy levels.	thcy	207-211	methylenetetrahydrofolate reductase	Homo sapiens	128-133
16704755-11	2006	Patients with the MTHFR TT genotype had higher plasma tHcy, serum creatinine, cholesterol and triglyceride concentrations than patients with the MTHFR CC genotype.	thcy	54-58	methylenetetrahydrofolate reductase	Homo sapiens	18-23
16453352-6	2006	The beta(nuc) value and steric factors dictate a regime whereby, at physiological pH values (pH 7.4), maximal reactivity of tHcy is exhibited with primary amine groups with a pK(a) value of 7.7; this allows the reactivity of various protein amino groups towards N-homocysteinylation to be predicted.	thcy	124-128	nucleobindin 1	Homo sapiens	9-12
16297937-7	2006	In conclusion, our study shows that in children with autism there are higher levels of tHcy, which is negatively correlated with GPx activity, low PON1 arylesterase activity and suboptimal levels of vitamin B(12).	thcy	87-91	paraoxonase 1	Homo sapiens	147-151
16340945-2	2006	OBJECTIVE: To examine the effects of changes in various lifestyle habits and lifestyle related biological CVD risk markers on changes in tHcy in relation to MTHFR(C677T) genotype.	thcy	137-141	methylenetetrahydrofolate reductase	Homo sapiens	157-162
16340945-8	2006	However, the MTHFR TT genotype was associated with a significant decrease in tHcy compared with the CC/CT genotype in which an increase was observed.	thcy	77-81	methylenetetrahydrofolate reductase	Homo sapiens	13-18
16681562-16	2006	Genotypic characteristics suggest that C(677)T MTHFR mutation confers a higher risk for stroke to both homozygous and heterozygous T allele carriers that cannot be ascribed solely to raised tHcy and/or lower folate status in CT subjects, nor to phenotypic expression of conventional risk factors for stroke.	thcy	190-194	methylenetetrahydrofolate reductase	Homo sapiens	47-52
16543681-12	2006	In conclusion, tHcy was increased in hypothyroidism, and this increase was more strongly associated with changes in serum folate than in serum creatinine and CysC, suggesting an altered folate status.	thcy	15-19	cystatin C	Homo sapiens	158-162
16522921-5	2006	RESULTS: Subjects with the MTHFR 677TT genotype had higher serum tHcy concentrations than did those with the MTHFR 677CC genotype (P < 0.001), and this effect was greater in subjects with low serum folate status (P for interaction = 0.026).	thcy	65-69	methylenetetrahydrofolate reductase	Homo sapiens	27-32
16522921-8	2006	An interaction (P = 0.05) was observed between the MTHFR 677TT and RFC1 80GG genotypes, whereby persons with this genotype combination had a mean (+/-SEM) serum tHcy concentration (18.5 +/- 1.2 micromol/L) that was 5.1 micromol/L greater than the mean value of 13.4 +/- 0.2 micromol/L for the whole population.	thcy	161-165	methylenetetrahydrofolate reductase	Homo sapiens	51-56
16522921-10	2006	An interaction between the MTHFR 677TT and RFC1 80GG genotypes was observed whereby persons with this combination had higher serum tHcy.	thcy	131-135	methylenetetrahydrofolate reductase	Homo sapiens	27-32
16391331-1	2006	BACKGROUND: Treatment with folic acid and vitamin B12 appears to be effective in lowering total plasma homocysteine (tHcy) concentrations, but whether vitamin B12 alone lowers tHcy in patients with normal vitamin B12 status is unknown.	thcy	117-121	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	50-53
16373648-7	2006	Baseline vitamin B12, serum folate, and tHcy were significantly associated with changes in plasma tHcy at follow-up (r=0.252, r=0.522, and r=-0.903, respectively; P=0.003, <0.001, and <0.001, respectively) in the vitamin group.	thcy	98-102	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	17-20
16373648-8	2006	CONCLUSIONS: The tHcy-lowering effect of B vitamins was maximal in those who had low B12 or high tHcy levels.	thcy	17-21	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	85-88
16397167-10	2006	MTHFR C677T genotype was an independent determinant of tHcy levels at baseline (P=0.005), but A1298C was not (P=0.08).	thcy	55-59	methylenetetrahydrofolate reductase	Homo sapiens	0-5
16397167-14	2006	MTHFR C677T but not A1298C is independently associated with tHcy levels at baseline, and neither impacts the tHcy-lowering effect of vitamins used in this study.	thcy	60-64	methylenetetrahydrofolate reductase	Homo sapiens	0-5
16234842-1	2006	OBJECTIVE: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	thcy	205-209	methylenetetrahydrofolate reductase	Homo sapiens	111-146
16234842-1	2006	OBJECTIVE: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.	thcy	205-209	methylenetetrahydrofolate reductase	Homo sapiens	148-153
16234842-12	2006	CONCLUSIONS: Under conditions of lower folate status (as estimated by either plasma concentration or reported dietary consumption), gender modifies the association of the MTHFR(C677T) polymorphism with tHcy concentrations in healthy children.	thcy	202-206	methylenetetrahydrofolate reductase	Homo sapiens	171-176
16391331-2	2006	The aims of the present study were to explore the effect of individual supplementation with folic acid or vitamin B12 on tHcy concentrations in hemodialysis (HD) patients and to compare changes in tHcy concentrations with MTHFR genotype.	thcy	121-125	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	114-117
16391331-11	2006	CONCLUSION: The alternating vitamin treatment demonstrated for the first time the importance of folate therapy and the secondary contribution of vitamin B12 in lowering tHcy in HD patients.	thcy	169-173	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	153-156
16297587-4	2006	However, in the baseline dementia-free cohort considered as a whole, independently of other confounders, IL-1beta-511 T/T homozygotes had lower plasma tHcy than both heterozygotes (P=0.036) and wild-types (P=0.004).	thcy	151-155	interleukin 1 alpha	Homo sapiens	105-113
16681435-12	2006	CONCLUSIONS: The significant percentage of elevated tHcy levels observed in healthy preschool cases and the negative tHcy correlation with PON1 activity are reported for the first time.	thcy	117-121	paraoxonase 1	Homo sapiens	139-143
16681435-11	2006	On the contrary, a weak negative relationship between tHcy concentration and PON1 activity was detected, with Pearson"s correlation coefficient of r=-0.27.	thcy	54-58	paraoxonase 1	Homo sapiens	77-81
16681435-12	2006	CONCLUSIONS: The significant percentage of elevated tHcy levels observed in healthy preschool cases and the negative tHcy correlation with PON1 activity are reported for the first time.	thcy	52-56	paraoxonase 1	Homo sapiens	139-143
16391477-7	2006	The significant association between plasma tHcy concentration and vascular disease remained after correction for age and for cystatin C differences between the groups of patients without and with vascular disease.	thcy	43-47	cystatin C	Homo sapiens	125-135
16297587-6	2006	The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD.	thcy	51-55	interleukin 1 alpha	Homo sapiens	64-72
17117898-1	2006	BACKGROUND: The nitric oxide synthase (NOS3) G894T gene polymorphism seems as a genetic determinant of total homocysteine (tHcy) concentrations through an effect on folate catabolism.	thcy	123-127	nitric oxide synthase 3	Homo sapiens	39-43
17117898-9	2006	CONCLUSION: Our results showed a modulating effect of the NOS3 4a/b gene variant on tHcy concentrations that is at least partially provoked by discrete blood pressure increments.	thcy	84-88	nitric oxide synthase 3	Homo sapiens	58-62
16777759-5	2006	tHcy correlated significantly with serum folate, serum vitamin B12, serum creatinine and congestive heart failure, but not with red blood cell folate, cerebrovascular disease, coronary heart disease or cognitive impairment.	thcy	0-4	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	63-66
16275827-2	2005	tHcy may potentiate neurotoxic and vasculopathic processes, including amyloid beta protein (Abeta) metabolism, implicated in neurodegenerative diseases.	thcy	0-4	amyloid beta precursor protein	Homo sapiens	92-97
16259797-2	2005	MTHFR C(677)T increases tHcy in association with low folate.	thcy	24-28	methylenetetrahydrofolate reductase	Homo sapiens	0-5
16624085-1	2006	OBJECTIVE: To study the relationship between metabolic control and the plasma total homocysteine (tHcy) in type 2 diabetes treated with insulin.	thcy	98-102	insulin	Homo sapiens	136-143
16624085-10	2006	CONCLUSIONS: After insulin treatment, the plasma tHcy decreases when the metabolic control is improved significantly.	thcy	49-53	insulin	Homo sapiens	19-26
16303969-1	2005	PURPOSE: The aim of this case-control study was to investigate the relationship between homocysteine (tHcy), 5,10 methylene tetrahydrofolate reductase (MTHFR) C677T genotype, folate and vitamin B12 status, and retinal vein occlusion (RVO).	thcy	102-106	methylenetetrahydrofolate reductase	Homo sapiens	152-157
16316363-2	2005	The methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, an important determinant of plasma tHcy concentrations, could therefore constitute an important prognostic marker.	thcy	107-111	methylenetetrahydrofolate reductase	Homo sapiens	4-39
16316363-2	2005	The methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, an important determinant of plasma tHcy concentrations, could therefore constitute an important prognostic marker.	thcy	107-111	methylenetetrahydrofolate reductase	Homo sapiens	41-46
16275827-8	2005	tHcy levels positively correlated with plasma Abeta levels even after adjustments for age and creatinine (p < 0.0001).	thcy	0-4	amyloid beta precursor protein	Homo sapiens	46-51
16275827-10	2005	The positive association between tHcy and plasma Abeta levels raises the possibility that these circulating factors could interact to affect AD risk and cognition in PD.	thcy	33-37	amyloid beta precursor protein	Homo sapiens	49-54
15972722-1	2005	Cystathionine beta-synthase (CBS) deficiency is a recessive genetic disorder in humans characterized by elevated levels of total plasma homocysteine (tHcy) and frequent thrombosis in humans.	thcy	150-154	cystathionine beta-synthase	Homo sapiens	0-27
16314912-7	2005	Total homocysteine and Lp(a) levels were found to be higher in the metabolic syndrome group than in the control group (tHcy: 24.2 vs 13.4 micromol/l, P &lt; 0.01 and Lp(a): 34.9 vs 15.8 mg/dl, P &lt; 0.01).	thcy	119-123	lipoprotein(a)	Homo sapiens	23-28
16190942-7	2005	In contrast, polymorphisms in the methylene tetrahydrofolate reductase gene (MTHFR 677 C--&gt;T, 1298 A--&gt;C, 1793 G--&gt;A) had no significant impact on tHcy.	thcy	156-160	methylenetetrahydrofolate reductase	Homo sapiens	77-82
16076517-4	2005	Homozygosity for MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (P&lt;0.01), which was mainly driven by the male group.	thcy	56-60	methylenetetrahydrofolate reductase	Homo sapiens	17-22
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	thcy	257-261	methylenetetrahydrofolate reductase	Homo sapiens	85-120
16178442-9	2005	During supplementation of folate, normalization of Thcy levels was accompanied by a marked reduction of MCP-1 expression in aortic endothelium and by a significant decrease of MCP-1 released from PBMC stimulated by oxidized low density lipoprotein (P &lt; 0.05, P &lt; 0.01).	thcy	51-55	C-C motif chemokine ligand 2	Rattus norvegicus	104-109
15057566-5	2005	C-reactive protein levels also correlated significantly in a negative manner with vitamin B12 and folate but positively with tHcy.	thcy	125-129	C-reactive protein	Homo sapiens	0-18
16002814-2	2005	Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C--&gt;T and 1298A--&gt;C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene.	thcy	257-261	methylenetetrahydrofolate reductase	Homo sapiens	122-127
16002814-10	2005	CONCLUSIONS: Moderate alcohol intake and low MTHFR activity have adverse effects on tHcy, but those effects may be overcome by sufficient folate intake.	thcy	84-88	methylenetetrahydrofolate reductase	Homo sapiens	45-50
16006259-9	2005	RESULTS: Plasma Iso-P, serum amyloid A (S-AA), and plasma intercellular adhesion molecule-1 (ICAM-1) concentrations were higher in patients with high plasma tHcy levels than in patients with low to normal tHcy levels.	thcy	157-161	intercellular adhesion molecule 1	Homo sapiens	58-91
15779086-3	2005	We found that the catechol-O-methyltransferase (COMT) substrate 3,4-dihydroxybenzoic acid (DHB) increased export of tHcy in astrocytes, but not in neurons.	thcy	116-120	catechol-O-methyltransferase	Homo sapiens	18-46
15779086-3	2005	We found that the catechol-O-methyltransferase (COMT) substrate 3,4-dihydroxybenzoic acid (DHB) increased export of tHcy in astrocytes, but not in neurons.	thcy	116-120	catechol-O-methyltransferase	Homo sapiens	48-52
15779086-5	2005	tHcy export from astrocytes was also induced by the COMT substrates levodopa (L-DOPA), dopamine and quercetin, and it was blocked by the COMT inhibitors tropolone and entacapone.	thcy	0-4	catechol-O-methyltransferase	Homo sapiens	52-56
15779086-5	2005	tHcy export from astrocytes was also induced by the COMT substrates levodopa (L-DOPA), dopamine and quercetin, and it was blocked by the COMT inhibitors tropolone and entacapone.	thcy	0-4	catechol-O-methyltransferase	Homo sapiens	137-141
15779086-6	2005	This export was associated with increased synthesis of tHcy because both intracellular and extracellular tHcy concentrations rose during COMT activation.	thcy	55-59	catechol-O-methyltransferase	Homo sapiens	137-141
15779086-7	2005	Incubation in cyst(e)ine-deficient medium inhibited the tHcy export response to COMT activation.	thcy	56-60	catechol-O-methyltransferase	Homo sapiens	80-84
15918903-3	2005	This may be due to effects of insulin and/or glucose and/or metabolic control on the metabolism or plasma levels of tHcy.	thcy	116-120	insulin	Homo sapiens	30-37
15883436-1	2005	BACKGROUND: Vitamin status, methylenentetrahydrofolate reductase (MTHFR) genotype, age, sex, and lifestyle factors are all predictors of total homocysteine (tHcy) concentrations in adults.	thcy	157-161	methylenetetrahydrofolate reductase	Homo sapiens	66-71
15883436-14	2005	The MTHFR 677C--&gt;T polymorphism played a minor role in determining tHcy concentrations in children.	thcy	70-74	methylenetetrahydrofolate reductase	Homo sapiens	4-9
16119521-8	2005	In both groups, plasma tHcy was positively related to serum leptin, but serum apolipoprotein B (apo B) levels were positively related to plasma tHcy levels only in obese patients.	thcy	23-27	leptin	Homo sapiens	60-66
16119521-8	2005	In both groups, plasma tHcy was positively related to serum leptin, but serum apolipoprotein B (apo B) levels were positively related to plasma tHcy levels only in obese patients.	thcy	144-148	apolipoprotein B	Homo sapiens	78-94
16119521-9	2005	CONCLUSIONS: Our study demonstrates for the first time that leptin and apo B are main correlates of tHcy in obese children and adolescents and suggests that hyperleptinemia and increased apo B may contribute to impairment of tHcy metabolism in childhood obesity.	thcy	100-104	leptin	Homo sapiens	60-66
15785306-1	2005	BACKGROUND: Variation of plasma total homocysteine (tHcy) levels among individuals is modified by 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and selected atherosclerotic risk factors.	thcy	52-56	methylenetetrahydrofolate reductase	Homo sapiens	98-138
15871860-4	2005	The C677T MTHFR gene polymorphism was determined by analysis of HinfI restriction fragment length polymorphism tHcy levels were significantly lower in diabetic patients compared with control subjects (7.7 +/- 2.2 vs. 11.8 +/- 4.5 micromol/l, P &lt; 0.0001).	thcy	111-115	methylenetetrahydrofolate reductase	Homo sapiens	10-15
15871860-8	2005	On multiple regression, tHcy levels were associated with sex (P &lt; 0.03) and glucose levels (P &lt; 0.04) in diabetic patients, and with uric acid (P &lt; 0.002) and MTHFR genotype (P &lt; 0.03) in control subjects.	thcy	24-28	methylenetetrahydrofolate reductase	Homo sapiens	168-173
15735067-8	2005	An interaction between the MTHFR genotype and plasma folate on tHcy was detected (P = 0.047).	thcy	63-67	methylenetetrahydrofolate reductase	Homo sapiens	27-32
15735067-11	2005	The results also show that, similar to adults, plasma folate concentration is important in determining the contribution of the MTHFR C677T mutation to tHcy concentrations in children.	thcy	151-155	methylenetetrahydrofolate reductase	Homo sapiens	127-132
15927937-9	2005	We conclude that maternal vitamin B12 deficiency reflected in plasma tHcy concentration contributes to small size of Indian babies.	thcy	69-73	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
16036726-8	2005	This first report of apoE4, plasma tHcy, MTL thickness, and AD from Sri Lanka shows that high plasma tHcy, the presence of apoE4 allele, and MTL atrophy are associated with AD.	thcy	101-105	sorcin	Homo sapiens	68-71
15785306-1	2005	BACKGROUND: Variation of plasma total homocysteine (tHcy) levels among individuals is modified by 5,10-methylenetetrahydrofolate reductase (MTHFR) genotypes and selected atherosclerotic risk factors.	thcy	52-56	methylenetetrahydrofolate reductase	Homo sapiens	140-145
16006259-9	2005	RESULTS: Plasma Iso-P, serum amyloid A (S-AA), and plasma intercellular adhesion molecule-1 (ICAM-1) concentrations were higher in patients with high plasma tHcy levels than in patients with low to normal tHcy levels.	thcy	157-161	intercellular adhesion molecule 1	Homo sapiens	93-99
16006259-15	2005	Levels of plasma ICAM-1 and S-AA were increased in patients with high plasma tHcy, suggesting an association between homocysteinemia and low-grade inflammation.	thcy	77-81	intercellular adhesion molecule 1	Homo sapiens	17-23
15585767-11	2004	The difference in tHcy according to MTHFR genotype was not significant.	thcy	18-22	methylenetetrahydrofolate reductase	Homo sapiens	36-41
15319318-1	2004	BACKGROUND: Newborn screening for total homocysteine (tHcy) in blood may identify babies with vitamin B12 (B12) deficiency or homocystinuria, but data on the causes of increased tHcy in screening samples are sparse.	thcy	54-58	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	102-105
15447919-1	2004	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C--&gt;T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy).	thcy	220-224	methylenetetrahydrofolate reductase	Homo sapiens	21-56
15447919-1	2004	BACKGROUND: The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C--&gt;T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy).	thcy	220-224	methylenetetrahydrofolate reductase	Homo sapiens	63-68
15447919-3	2004	OBJECTIVE: The aim of the study was to investigate the phenotypic expression of the MTHFR 677C--&gt;T polymorphism in terms of plasma tHcy concentrations in patients with thyroid dysfunction.	thcy	134-138	methylenetetrahydrofolate reductase	Homo sapiens	84-89
15369747-6	2004	In diabetic patients, plasma tHcy correlated positively with urinary albumin, fibrinogen, IL-6 and plasmin-alpha2-antiplasmin complex (PAP), while plasma tHcy correlated negatively with creatinine clearance (Ccr) and protein C activity.	thcy	29-33	fibrinogen beta chain	Homo sapiens	78-88
15369747-6	2004	In diabetic patients, plasma tHcy correlated positively with urinary albumin, fibrinogen, IL-6 and plasmin-alpha2-antiplasmin complex (PAP), while plasma tHcy correlated negatively with creatinine clearance (Ccr) and protein C activity.	thcy	29-33	interleukin 6	Homo sapiens	90-94
15369747-7	2004	After adjustment for Ccr, IL-6 and protein C activity were significantly associated with plasma tHcy.	thcy	96-100	interleukin 6	Homo sapiens	26-30
15319318-1	2004	BACKGROUND: Newborn screening for total homocysteine (tHcy) in blood may identify babies with vitamin B12 (B12) deficiency or homocystinuria, but data on the causes of increased tHcy in screening samples are sparse.	thcy	54-58	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
15319318-5	2004	B12 status, as determined by serum concentrations of B12, tHcy, and MMA, was moderately better in boys than in girls.	thcy	58-62	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	0-3
15319318-6	2004	tHcy concentrations between 10 and 20 micromol/L were often associated with low B12, whereas tHcy &gt; 20 micromol/L (n = 43) was nearly always explained by increased methionine.	thcy	0-4	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	80-83
15332218-4	2004	RESULTS: Ninety-three patients (37%) with signs of inflammation (CRP &gt; or = 1 mg/dL) had significantly lower levels of tHcy, tCys, and serum Alb than 157 noninflamed patients.	thcy	122-126	C-reactive protein	Homo sapiens	65-68
15466944-9	2004	Increased plasma THCy level was found in 10 children and adolescents from 12 cases homozygous for the C677T polymorphism of the MTHFR gene.	thcy	17-21	methylenetetrahydrofolate reductase	Homo sapiens	128-133
15332218-5	2004	tHcy and tCys levels correlated positively with serum Alb levels and negatively with CRP levels (rho = -0.24; P &lt; 0.0001; rho = -0.15; P &lt; 0.05, respectively) and other inflammation markers.	thcy	0-4	albumin	Homo sapiens	54-57
15332218-5	2004	tHcy and tCys levels correlated positively with serum Alb levels and negatively with CRP levels (rho = -0.24; P &lt; 0.0001; rho = -0.15; P &lt; 0.05, respectively) and other inflammation markers.	thcy	0-4	C-reactive protein	Homo sapiens	85-88
15332218-8	2004	Multivariate analysis showed that serum Alb, CRP, plasma folate, and vitamin B12 levels were independently associated with tHcy levels after adjustment for other variables.	thcy	123-127	albumin	Homo sapiens	40-43
15332218-8	2004	Multivariate analysis showed that serum Alb, CRP, plasma folate, and vitamin B12 levels were independently associated with tHcy levels after adjustment for other variables.	thcy	123-127	C-reactive protein	Homo sapiens	45-48
15475827-5	2004	In conclusion, in POC there is a lack, in contrast to PLC, of a possibly autoregulatory, negative association of elevated tHcy levels to increased MCP-1 and RANTES levels.	thcy	122-126	C-C motif chemokine ligand 2	Homo sapiens	147-152
15475827-4	2004	In PLC, but not in POC, tHcy levels were negatively associated with both circulating MCP-1 (B = -1.68, P = 0.007) and RANTES (B = -1.16, P = 0.01) after adjusting for age, sex, BMI, as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels.	thcy	24-28	C-C motif chemokine ligand 2	Homo sapiens	85-90
15475827-5	2004	In conclusion, in POC there is a lack, in contrast to PLC, of a possibly autoregulatory, negative association of elevated tHcy levels to increased MCP-1 and RANTES levels.	thcy	122-126	C-C motif chemokine ligand 5	Homo sapiens	157-163
15151507-2	2004	While the thermolabile polymorphism in MTHFR encoding methylenetetrahydrofolate reductase is the best-studied genetic factor associated with variation in plasma tHCy, other candidate genes are being evaluated.	thcy	161-165	methylenetetrahydrofolate reductase	Homo sapiens	39-44
15475827-4	2004	In PLC, but not in POC, tHcy levels were negatively associated with both circulating MCP-1 (B = -1.68, P = 0.007) and RANTES (B = -1.16, P = 0.01) after adjusting for age, sex, BMI, as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels.	thcy	24-28	C-C motif chemokine ligand 5	Homo sapiens	118-124
15475827-4	2004	In PLC, but not in POC, tHcy levels were negatively associated with both circulating MCP-1 (B = -1.68, P = 0.007) and RANTES (B = -1.16, P = 0.01) after adjusting for age, sex, BMI, as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels.	thcy	24-28	insulin	Homo sapiens	204-211
15136061-5	2004	The MTHFR 677TT genotype was significantly associated with elevated tHcy concentrations in smokers (P = 0.001) but not in non-smokers (P = 0.36).	thcy	68-72	methylenetetrahydrofolate reductase	Homo sapiens	4-9
15136061-6	2004	Among smokers, the MTHFR 677TT genotype was significantly associated with high tHcy in heavy smokers (P = 0.003) but not light smokers (P = 0.09), in men (P = 0.003) but not women (P = 0.11), and in subjects from the lowest serum folate quartile (P = 0.49) but not from folate quartiles 2-4 (P = 0.49).	thcy	79-83	methylenetetrahydrofolate reductase	Homo sapiens	19-24
15200442-8	2004	CONCLUSION: Data from a group consisting of patients with CRF, patients undergoing maintenance hemodialysis treatment, and renal transplant recipients provide evidence that conventional risk factors such as the presence of diabetes, ESRD, as well as elevated levels of the considered risk factor CRP, seem to play a more important role for cardiovascular outcome in patients with chronic kidney disease than elevated levels of AGEs, tHcy, and related metabolites.	thcy	433-437	C-reactive protein	Homo sapiens	296-299
15151507-2	2004	While the thermolabile polymorphism in MTHFR encoding methylenetetrahydrofolate reductase is the best-studied genetic factor associated with variation in plasma tHCy, other candidate genes are being evaluated.	thcy	161-165	methylenetetrahydrofolate reductase	Homo sapiens	54-89
15151507-6	2004	CTH 1364T/T homozygotes had significantly higher mean plasma tHcy concentration than subjects with other genotypes, and the effect sizes of CTH and MTHFR genotypes were similar.	thcy	61-65	V-set and immunoglobulin domain containing 2	Homo sapiens	0-3
15151507-7	2004	The findings suggest that common variation in CTH may be a determinant of plasma tHcy concentrations.	thcy	81-85	V-set and immunoglobulin domain containing 2	Homo sapiens	46-49
15044114-3	2004	The tHcy value was significantly lower (p &lt; 0.001) in young women with CC or CT of MTHFR than with TT (10.9+/-4.7 micromol/L) (n =250).	thcy	4-8	methylenetetrahydrofolate reductase	Homo sapiens	86-91
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	thcy	149-153	cystathionine beta-synthase	Homo sapiens	19-46
15148140-10	2004	Daily levodopa/dopa decarboxylase inhibitor intake was significantly related to tHcy levels (R = 0.43; P =.02).	thcy	80-84	dopa decarboxylase	Homo sapiens	15-33
15099281-8	2004	CONCLUSION: The results of the present study demonstrate that the eNOS 894 G &gt; T variation interacts with elevated tHcy levels, leading to an increased risk of recurrent thrombotic events.	thcy	118-122	nitric oxide synthase 3	Homo sapiens	66-70
15036404-2	2004	However, the association between plasma tHcy and serum C-reactive protein (sCRP), taken as a marker of low-grade inflammation, is still uncertain.	thcy	40-44	C-reactive protein	Homo sapiens	55-73
15073633-1	2004	The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease.	thcy	146-150	methylenetetrahydrofolate reductase	Homo sapiens	30-65
15073633-1	2004	The C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease.	thcy	146-150	methylenetetrahydrofolate reductase	Homo sapiens	72-77
15036404-5	2004	A positive association between plasma tHcy and serum CRP, independent of several confounders (socio-demographic status, known tHcy and sCRP determinants, inflammation markers, traditional vascular risk factors), was found for CVD+/comorbidity+ (p=0.001; not affected by dementia type) and dementia (p=0.001; not affected by dementia type), but not for CVD+/comorbidity- and controls.	thcy	38-42	C-reactive protein	Homo sapiens	53-56
15036404-5	2004	A positive association between plasma tHcy and serum CRP, independent of several confounders (socio-demographic status, known tHcy and sCRP determinants, inflammation markers, traditional vascular risk factors), was found for CVD+/comorbidity+ (p=0.001; not affected by dementia type) and dementia (p=0.001; not affected by dementia type), but not for CVD+/comorbidity- and controls.	thcy	126-130	C-reactive protein	Homo sapiens	53-56
14747392-5	2004	tHcy had weak to moderate but statistically significant bivariate and multivariate correlations with some laboratory markers of nutrition (serum albumin, prealbumin, creatinine, and urea nitrogen) but no significant correlation with serum C-reactive protein or two proinflammatory cytokines (IL-6 and TNF-alpha).	thcy	0-4	albumin	Homo sapiens	145-152
15255449-1	2004	OBJECTIVES: The aim of this study was to investigate whether an increase in total homocysteine (tHcy) concentration with increasing age is due to diminishing serum concentrations of pyridoxal-5-phosphate (PLP), vitamin B-12, and folate.	thcy	96-100	pyridoxal phosphatase	Homo sapiens	205-208
15255449-7	2004	CONCLUSION: Higher tHcy concentrations in the elderly, in comparison to younger women, are due to lower serum concentrations of PLP, vitamin B-12, and folate, whereas within the age group of elderly subjects alone tHcy concentrations increase with age irrespective of serum vitamin concentrations.	thcy	19-23	pyridoxal phosphatase	Homo sapiens	128-131
15019536-7	2004	Subjects homozygous for the rare MTHFR T allele had 34% higher median tHcy concentrations than CC homozygotes or CT heterozygotes, but responses to gemfibrozil did not differ significantly among genotypes.	thcy	70-74	methylenetetrahydrofolate reductase	Homo sapiens	33-38
15040829-4	2004	Individuals homozygous (TT) for the MTHFR C677T polymorphism who have low plasma folate concentrations exhibit elevated plasma homocysteine (tHcy) concentrations that may compromise bone quality.	thcy	141-145	methylenetetrahydrofolate reductase	Homo sapiens	36-41
14747392-5	2004	tHcy had weak to moderate but statistically significant bivariate and multivariate correlations with some laboratory markers of nutrition (serum albumin, prealbumin, creatinine, and urea nitrogen) but no significant correlation with serum C-reactive protein or two proinflammatory cytokines (IL-6 and TNF-alpha).	thcy	0-4	interleukin 6	Homo sapiens	292-296
14747392-5	2004	tHcy had weak to moderate but statistically significant bivariate and multivariate correlations with some laboratory markers of nutrition (serum albumin, prealbumin, creatinine, and urea nitrogen) but no significant correlation with serum C-reactive protein or two proinflammatory cytokines (IL-6 and TNF-alpha).	thcy	0-4	tumor necrosis factor	Homo sapiens	301-310
14747392-9	2004	Relative risk of death for the lowest tHcy quartile, even after adjustment for case-mix and serum albumin, was 2.27 (95% confidence interval, 1.14 to 4.53; P = 0.02).	thcy	38-42	albumin	Homo sapiens	98-105
14758571-9	2004	A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase.	thcy	36-40	methylenetetrahydrofolate reductase	Homo sapiens	193-198
14742985-7	2004	RESULTS: Plasma PAI-1 Ag levels were the highest in patients with the 4G/4G genotype, and plasma tHcy levels were the highest in patients with TT genotypes of MTHFR C677T.	thcy	97-101	methylenetetrahydrofolate reductase	Homo sapiens	159-164
15002923-2	2004	C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy).	thcy	130-134	methylenetetrahydrofolate reductase	Homo sapiens	22-27
14758571-9	2004	A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase.	thcy	36-40	insulin	Homo sapiens	243-250
14758571-9	2004	A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase.	thcy	259-263	methylenetetrahydrofolate reductase	Homo sapiens	193-198
14758571-9	2004	A stepwise regression analysis with tHcy plasma level variations (event A = reduction; event B = increase) as the dependent variable showed that low serum folate and PLP levels and presence of MTHFR T allele were the variables associated with insulin-induced tHcy increase.	thcy	259-263	insulin	Homo sapiens	243-250
12897987-3	2003	We then examined the relationship between plasma levels of tHcy and TGF-beta1 in renal graft recipients.	thcy	59-63	transforming growth factor beta 1	Homo sapiens	68-77
15912197-3	2004	There was a significant elevation of plasma tHcy in the patients group and Gp2 compared to the young control group (Gp1).	thcy	44-48	GTP binding protein 1	Homo sapiens	116-119
12897987-5	2003	A 31% increase in tHcy was observed after exposure of huRPTECs to TGF-beta1 compared to medium alone.	thcy	18-22	transforming growth factor beta 1	Homo sapiens	66-75
14624417-10	2003	By multivariate analysis, total cholesterol, urinary albumin, Ccr, C-peptide, and tHcy retained significant influence on the plasma TM.	thcy	82-86	thrombomodulin	Homo sapiens	132-134
14624417-11	2003	Even in patients with normal renal function (Ccr &gt; or = 80 mL/min), plasma tHcy was correlated positively with plasma TM.	thcy	78-82	thrombomodulin	Homo sapiens	121-123
14624417-13	2003	Since plasma TM is independently associated with plasma tHcy, in diabetic patients with overt nephropathy, elevation of tHcy reflecting reduced clearance is a likely cause of endothelial dysfunction, resulting in the atherosclerosis underlying development of cardiovascular disease.	thcy	56-60	thrombomodulin	Homo sapiens	13-15
14624417-13	2003	Since plasma TM is independently associated with plasma tHcy, in diabetic patients with overt nephropathy, elevation of tHcy reflecting reduced clearance is a likely cause of endothelial dysfunction, resulting in the atherosclerosis underlying development of cardiovascular disease.	thcy	120-124	thrombomodulin	Homo sapiens	13-15
12930236-10	2003	A multivariate analysis revealed MTHFR polymorphism and HbA1c as strong determinants of changes in tHcy with time.	thcy	99-103	methylenetetrahydrofolate reductase	Homo sapiens	33-38
14608052-2	2003	However, little is known about the influence of subject characteristics, such as age and sex, on the relation between the C677T MTHFR polymorphism and fasting plasma total homocysteine (tHcy) concentrations.	thcy	186-190	methylenetetrahydrofolate reductase	Homo sapiens	128-133
14608052-10	2003	Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations.	thcy	100-104	methylenetetrahydrofolate reductase	Homo sapiens	68-73
12930236-11	2003	CONCLUSIONS: The findings suggest that in D2p tHcy decreases even with modest improvement of glycaemic control; moreover patients homozygous for the MTHFR C677T mutation show the largest changes in tHcy levels with concomitant changing of HbA1c.	thcy	198-202	methylenetetrahydrofolate reductase	Homo sapiens	149-154
12941729-9	2003	Plasma tHcy concentrations were significantly higher in patients with high IL-18 than in those with normal IL-18.	thcy	7-11	interleukin 18	Homo sapiens	75-80
12941729-9	2003	Plasma tHcy concentrations were significantly higher in patients with high IL-18 than in those with normal IL-18.	thcy	7-11	interleukin 18	Homo sapiens	107-112
12941729-10	2003	Univariate and multivariate analyses showed a strong independent association between tHcy and IL-18.	thcy	85-89	interleukin 18	Homo sapiens	94-99
12941729-13	2003	Plasma IL-18 is an independent determinant of plasma tHcy, which is linked independently with atherosclerotic carotid wall thickening.	thcy	53-57	interleukin 18	Homo sapiens	7-12
12911562-3	2003	Conflicting data exist with regard to the effect of a polymorphism in the gene coding for transcobalamin II, TCN2 776C&gt;G, on transcobalamin II levels in the general population, which in turn may affect holo-transcobalamin II, vitamin B12, as well as total homocysteine (tHcy) plasma levels.	thcy	273-277	transcobalamin 2	Homo sapiens	90-107
12911562-3	2003	Conflicting data exist with regard to the effect of a polymorphism in the gene coding for transcobalamin II, TCN2 776C&gt;G, on transcobalamin II levels in the general population, which in turn may affect holo-transcobalamin II, vitamin B12, as well as total homocysteine (tHcy) plasma levels.	thcy	273-277	transcobalamin 2	Homo sapiens	109-113
12911562-3	2003	Conflicting data exist with regard to the effect of a polymorphism in the gene coding for transcobalamin II, TCN2 776C&gt;G, on transcobalamin II levels in the general population, which in turn may affect holo-transcobalamin II, vitamin B12, as well as total homocysteine (tHcy) plasma levels.	thcy	273-277	transcobalamin 2	Homo sapiens	128-145
12911562-3	2003	Conflicting data exist with regard to the effect of a polymorphism in the gene coding for transcobalamin II, TCN2 776C&gt;G, on transcobalamin II levels in the general population, which in turn may affect holo-transcobalamin II, vitamin B12, as well as total homocysteine (tHcy) plasma levels.	thcy	273-277	transcobalamin 2	Homo sapiens	128-145
12911562-5	2003	METHODS: We examined the effect of TCN2 776C&gt;G on holo-transcobalamin II, vitamin B12, and tHcy plasma concentrations in 120 dialysis patients.	thcy	94-98	transcobalamin 2	Homo sapiens	35-39
12911562-6	2003	RESULTS: Holo-transcobalamin II levels were normal or supranormal in all patients and showed a linear association with albumin (r = 0.205, P = 0.025) and with vitamin B12 (r = 0.778, P = 0.001), but not with age, creatinine, body mass index, tHcy, ln-tHcy, vitamin B6, plasma folate, and red blood cell folate concentration.	thcy	242-246	transcobalamin 2	Homo sapiens	14-31
12911562-6	2003	RESULTS: Holo-transcobalamin II levels were normal or supranormal in all patients and showed a linear association with albumin (r = 0.205, P = 0.025) and with vitamin B12 (r = 0.778, P = 0.001), but not with age, creatinine, body mass index, tHcy, ln-tHcy, vitamin B6, plasma folate, and red blood cell folate concentration.	thcy	251-255	transcobalamin 2	Homo sapiens	14-31
12911562-9	2003	Independent predictors of ln-tHcy included creatinine, red blood cell folate, and the MTHFR 677TT genotype.	thcy	29-33	methylenetetrahydrofolate reductase	Homo sapiens	86-91
12911562-10	2003	There was also an effect of the TCN2 776CC genotype on ln-tHcy levels in this multivariate analysis, however, that deserves cautious interpretation because there was no effect of TCN2 genotypes by ANOVA and Scheffe test [median ln-tHcy concentrations according to TCN2 genotypes (micromol/L): CC, 3.22; CG, 3.30; GG, 3.23].	thcy	58-62	transcobalamin 2	Homo sapiens	32-36
12930236-11	2003	CONCLUSIONS: The findings suggest that in D2p tHcy decreases even with modest improvement of glycaemic control; moreover patients homozygous for the MTHFR C677T mutation show the largest changes in tHcy levels with concomitant changing of HbA1c.	thcy	46-50	methylenetetrahydrofolate reductase	Homo sapiens	149-154
12952548-6	2003	Log serum tHcy concentration showed borderline significant (p = 0.049) positive association with fasting serum insulin concentration independent of age and BMI, only in men aged 60-74.	thcy	10-14	insulin	Homo sapiens	111-118
12952548-8	2003	Further research is needed on the associations of serum tHcy concentration with insulin resistance and other components of the insulin resistance syndrome in persons of varying ethnicity.	thcy	56-60	insulin	Homo sapiens	80-87
12689917-9	2003	CONCLUSIONS: These data indicate that the NOS3 894TT genotype is a risk factor for elevated tHcy in healthy nonsmoking adults with low serum folate and supports the hypothesis that nitric oxide modulates homocysteine through an effect on folate catabolism.	thcy	92-96	nitric oxide synthase 3	Homo sapiens	42-46
14650352-7	2003	PA had a small but significant lowering effect on plasma tHcy adjusted for folate levels in subjects with the 677TT genotype of the MTHFR gene.	thcy	57-61	methylenetetrahydrofolate reductase	Homo sapiens	132-137
12854633-4	2003	There was an inverse correlation between tHcy levels and creatinine clearance in patients with PPH (P = 0.036).	thcy	41-45	enolase 1	Homo sapiens	95-98
14696755-11	2003	B12 treatment, had significantly lower tHcy (p &lt; 0.001) and FOL (p &lt; 0.05) serum levels, compared with those at the end of oral B12 treatment.	thcy	39-43	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	0-3
14696755-14	2003	There was a significant inverse correlation between tHcy and B12 (p &lt; 0.0001) at the end of the i.v.	thcy	52-56	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	61-64
14696755-18	2003	B12 treatment to reduce their elevated tHcy levels.	thcy	39-43	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	0-3
12689917-3	2003	Nitric oxide may also modulate plasma homocysteine (tHcy) concentrations, either by direct inhibition of methionine synthase or via an indirect effect on folate catabolism.	thcy	52-56	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	105-124
12689917-4	2003	METHODS AND RESULTS: The hypothesis that the endothelial nitric oxide synthase (NOS3) G894T polymorphism is a genetic determinant of tHcy concentrations was tested in 2 independent healthy adult populations.	thcy	133-137	nitric oxide synthase 3	Homo sapiens	45-78
12763276-8	2003	tHcy levels were negatively correlated with vitamin B(12) (r=-0.40, P=0.027) and positively correlated with PAI-1 and AuAb-oxLDL levels (r=0.46, P=0.011; r=0.39, P=0.035, respectively).	thcy	0-4	serpin family E member 1	Homo sapiens	108-113
12689917-4	2003	METHODS AND RESULTS: The hypothesis that the endothelial nitric oxide synthase (NOS3) G894T polymorphism is a genetic determinant of tHcy concentrations was tested in 2 independent healthy adult populations.	thcy	133-137	nitric oxide synthase 3	Homo sapiens	80-84
12689917-5	2003	In both populations, NOS3 genotype was significantly associated with tHcy concentrations in nonsmokers with low folate (P=0.03 for each).	thcy	69-73	nitric oxide synthase 3	Homo sapiens	21-25
12689917-7	2003	NOS3 genotype remained a significant determinant of tHcy concentrations after adjustment.	thcy	52-56	nitric oxide synthase 3	Homo sapiens	0-4
12797595-1	2003	The C677T transition of methylenetetrahydrofolate reductase (MTHFR) gene causes a moderate increase in total plasma homocysteine (tHcy).	thcy	130-134	methylenetetrahydrofolate reductase	Homo sapiens	24-59
12687650-3	2003	Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population.	thcy	142-146	methylenetetrahydrofolate reductase	Homo sapiens	46-81
12687650-3	2003	Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population.	thcy	142-146	methylenetetrahydrofolate reductase	Homo sapiens	83-88
12687650-3	2003	Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population.	thcy	205-209	methylenetetrahydrofolate reductase	Homo sapiens	46-81
12687650-3	2003	Like age and sex, the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR(C677T)) is an important nonmodifiable determinant of tHcy, which may be considered when describing normal ranges of tHcy in the general population.	thcy	205-209	methylenetetrahydrofolate reductase	Homo sapiens	83-88
12687650-4	2003	We investigated the simultaneous effect of sex, age, and MTHFR(C677T) genotype on the distribution of tHcy in a cross-sectional study design.	thcy	102-106	methylenetetrahydrofolate reductase	Homo sapiens	57-62
12687650-13	2003	The MTHFR(C677T) polymorphism explained 6% of the phenotypic variation in tHcy.	thcy	74-78	methylenetetrahydrofolate reductase	Homo sapiens	4-9
12687650-14	2003	In conclusion, we found that tHcy is associated with sex, age, and MTHFR genotype.	thcy	29-33	methylenetetrahydrofolate reductase	Homo sapiens	67-72
12753319-1	2003	BACKGROUND: The effect of the glutamate carboxypeptidase II GCP2 1561C&gt;T and the reduced folate carrier 1 RFC1 80G&gt;A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown.	thcy	171-175	replication factor C subunit 1	Homo sapiens	109-113
12707400-1	2003	This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G&gt;A) and the glutamate carboxypeptidase 2 (GCP2 1561C&gt;T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients.	thcy	216-220	folate hydrolase 1	Homo sapiens	141-169
12707400-1	2003	This study was designed to examine the effect of two single nucleotide polymorphisms in the reduced folate carrier 1 (RFC1 80G&gt;A) and the glutamate carboxypeptidase 2 (GCP2 1561C&gt;T) gene on total homocysteine (tHcy) plasma level and folate status in 120 chronic dialysis patients.	thcy	216-220	folate hydrolase 1	Homo sapiens	171-175
12707400-6	2003	A linear multivariate regression analysis showed that red blood cell folate (P &lt; 0.001), creatinine (P &lt; 0.001), and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677T allele (P = 0.013) are independent predictors of tHcy plasma level explaining 49% of the variance of tHcy plasma concentration.	thcy	230-234	methylenetetrahydrofolate reductase	Homo sapiens	127-167
12707400-6	2003	A linear multivariate regression analysis showed that red blood cell folate (P &lt; 0.001), creatinine (P &lt; 0.001), and the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677T allele (P = 0.013) are independent predictors of tHcy plasma level explaining 49% of the variance of tHcy plasma concentration.	thcy	282-286	methylenetetrahydrofolate reductase	Homo sapiens	127-167
12797595-1	2003	The C677T transition of methylenetetrahydrofolate reductase (MTHFR) gene causes a moderate increase in total plasma homocysteine (tHcy).	thcy	130-134	methylenetetrahydrofolate reductase	Homo sapiens	61-66
12618274-1	2003	OBJECTIVE: To determine whether plasma homocysteine (tHcy) levels were related to insulin resistance and obesity in subjects without diabetes or vascular disease.	thcy	53-57	insulin	Homo sapiens	82-89
12785413-7	2003	CONCLUSIONS: The higher serum tHcy concentrations observed in Hispanics compared to NHWs can be explained by lower levels of serum folate and vitamin B12.	thcy	30-34	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	150-153
12694331-4	2003	The most consistent effect on tHcy plasma concentrations is observed for 677C&gt;T of MTHFR, whereas GCP2, RFC1, and TCN2 polymorphisms show no major effect on tHcy concentrations.	thcy	30-34	methylenetetrahydrofolate reductase	Homo sapiens	86-91
12642343-3	2003	Serum folate, red cell folate, vitamin B(12), and tHcy concentrations were significantly influenced by MTHFR 677C&gt;T genotypes.	thcy	50-54	methylenetetrahydrofolate reductase	Homo sapiens	103-108
12642343-4	2003	A particularly strong interaction was observed between the MTHFR 677TT genotype and serum folate, which led to a high tHcy phenotype that was more pronounced in males.	thcy	118-122	methylenetetrahydrofolate reductase	Homo sapiens	59-64
12651974-3	2003	A common 677C--&gt;T mutation in the MTHFR gene results in decreased enzymic activity, and contributes to increased plasma tHcy, in association with low plasma folate.	thcy	123-127	methylenetetrahydrofolate reductase	Homo sapiens	37-42
12651974-4	2003	A recently described 1298A--&gt;C mutation in the MTHFR gene clearly reduces MTHFR activity (although to a lesser extent than the 677C--&gt;T) but its effect on plasma tHcy levels is not yet clear.	thcy	168-172	methylenetetrahydrofolate reductase	Homo sapiens	50-55
12651974-15	2003	Both MTHFR mutations showed effects on plasma tHcy levels.	thcy	46-50	methylenetetrahydrofolate reductase	Homo sapiens	5-10
12618274-5	2003	There was a significant relationship between plasma tHcy and S(I) (r=0.53, P=0.006), demonstrating that the more insulin sensitive subjects had higher levels of tHcy.	thcy	52-56	insulin	Homo sapiens	113-120
12618274-5	2003	There was a significant relationship between plasma tHcy and S(I) (r=0.53, P=0.006), demonstrating that the more insulin sensitive subjects had higher levels of tHcy.	thcy	161-165	insulin	Homo sapiens	113-120
12618274-6	2003	On log transformation of the plasma insulin values, log insulin correlated negatively with plasma tHcy (r=-0.47; P=0.02).	thcy	98-102	insulin	Homo sapiens	36-43
12618274-6	2003	On log transformation of the plasma insulin values, log insulin correlated negatively with plasma tHcy (r=-0.47; P=0.02).	thcy	98-102	insulin	Homo sapiens	56-63
12618274-11	2003	CONCLUSIONS: We conclude that in vitamin replete lean and obese individuals, insulin sensitivity correlates significantly with plasma tHcy.	thcy	134-138	insulin	Homo sapiens	77-84
12801809-8	2003	Third, the C667T transition of the methylenetetrahydrofolate reductase causes a moderate increase in tHcy but no or only minor increased CVD risk.	thcy	101-105	methylenetetrahydrofolate reductase	Homo sapiens	35-70
12603495-9	2003	The relative risk for death of all causes increased 1.43 (95% CI, 1.08-1.88) per tHcy quartile (P for trend = 0.01), and was only modestly reduced after adjustment for age, ejection fraction, total cholesterol, C-reactive protein, fibrinogen, smoking and hypertension to 1.37 (95% CI, 1.04-1.80) (P for trend = 0.03).	thcy	81-85	C-reactive protein	Homo sapiens	211-229
12603495-9	2003	The relative risk for death of all causes increased 1.43 (95% CI, 1.08-1.88) per tHcy quartile (P for trend = 0.01), and was only modestly reduced after adjustment for age, ejection fraction, total cholesterol, C-reactive protein, fibrinogen, smoking and hypertension to 1.37 (95% CI, 1.04-1.80) (P for trend = 0.03).	thcy	81-85	fibrinogen beta chain	Homo sapiens	231-241
12644913-2	2003	The combined effects of renal failure, folate and vitamin B(12) levels, and a common mutation (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene that leads to total plasma homocysteine (tHcy) elevation in CRF children were investigated.	thcy	199-203	methylenetetrahydrofolate reductase	Homo sapiens	109-144
12644913-2	2003	The combined effects of renal failure, folate and vitamin B(12) levels, and a common mutation (C677T) in the methylenetetrahydrofolate reductase (MTHFR) gene that leads to total plasma homocysteine (tHcy) elevation in CRF children were investigated.	thcy	199-203	methylenetetrahydrofolate reductase	Homo sapiens	146-151
24122328-13	2003	No correlation was found between tHcy concentration and the number of vascular access thrombotic events; homozygotes for MTHFR had higher tHcy but no more vascular access thrombotic events.	thcy	138-142	methylenetetrahydrofolate reductase	Homo sapiens	121-126
12560354-3	2003	Individuals with the MTHFR 677C--&gt;T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	21-26
12560354-10	2003	CONCLUSIONS: Folate and riboflavin interact to lower plasma tHcy, possibly by maximizing the catalytic activity of MTHFR.	thcy	60-64	methylenetetrahydrofolate reductase	Homo sapiens	115-120
12601627-11	2003	Further supplementation with 1 mg vitamin B(12) resulted in greater tHcy reduction among subjects with the MTHFR 677 T/T genotype (P&lt;.01, T/T v C/C or C/T) while lowering MMA equally in all MTHFR genotypes.	thcy	68-72	methylenetetrahydrofolate reductase	Homo sapiens	107-112
12604408-4	2003	DESIGN AND METHODS: We evaluated whether fasting tHcy levels were useful to predict PML and deltaPML tHcy with acceptable sensitivity and specificity in 381 patients with venous and arterial thrombosis through the generation of receiver operating characteristic curves.	thcy	49-53	PML nuclear body scaffold	Homo sapiens	84-87
12604408-5	2003	RESULTS: Both PML and deltaPML tHcy correlated with fasting tHcy values.	thcy	60-64	PML nuclear body scaffold	Homo sapiens	14-17
12604408-6	2003	The cut-off of fasting tHcy value yielding a 100% sensitivity in predicting normal PML and deltaPML tHcy was 6.5 and 5.0 micromol/L in females, and 7.1 and 7.2 micromol/L in males.	thcy	23-27	PML nuclear body scaffold	Homo sapiens	83-86
12604408-7	2003	Fasting tHcy values yielding a 95% specificity in predicting a positive PML and tHcy result ranged from 12.5 to 13.1 micromol/L in males and from 10.4 to 10.5 micromol/L in females.	thcy	8-12	PML nuclear body scaffold	Homo sapiens	72-75
12548301-8	2003	Homozygote frequency for MTHFR genotype TT was 5.0% and their plasma tHcy was 14.8 micro mol/l compared to the mean of the other subjects, 10.5 micro mol/l, P&lt;0.05.	thcy	69-73	methylenetetrahydrofolate reductase	Homo sapiens	25-30
12514270-3	2003	Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels.	thcy	202-206	folate hydrolase 1	Homo sapiens	38-67
12514270-3	2003	Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels.	thcy	202-206	folate hydrolase 1	Homo sapiens	69-74
12514270-3	2003	Recently, a H475Y polymorphism in the glutamate carboxypeptidase II (GCPII) gene, encoding the FGCP enzyme, was reported to be associated with decreased plasma folate and increased plasma homocysteine (tHcy) levels.	thcy	202-206	folate hydrolase 1	Homo sapiens	95-99
14698652-4	2003	tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels &gt; 30 micromol/l had the MTHFR C677T homozygous substitution.	thcy	75-79	methylenetetrahydrofolate reductase	Homo sapiens	114-119
14698652-5	2003	Elevated tHcy levels (p &lt; 0.05) were identified in smokers and coffee drinkers, with the degree of elevation dependent on MTHFR C677T genotype.	thcy	9-13	methylenetetrahydrofolate reductase	Homo sapiens	125-130
14698652-4	2003	tHcy levels were a function of MTHFR C677T genotype, and all patients with tHcy levels &gt; 30 micromol/l had the MTHFR C677T homozygous substitution.	thcy	0-4	methylenetetrahydrofolate reductase	Homo sapiens	31-36
12473014-7	2002	tHcy was negatively associated with total CAMCOG score independent of years of education, serum folate, vitamin B12, and cystatin C levels.	thcy	0-4	cystatin C	Homo sapiens	121-131
12486492-7	2002	After controlling for age and sex, multiple regression analyses showed significant associations of plasma tHcy concentration with glycated hemoglobin (p&lt;0.05), plasma concentrations of creatinine (p&lt;0.001) and apolipoprotein-B (p&lt;0.05), but not with smoking, neuropathy or retinopathy.	thcy	106-110	apolipoprotein B	Homo sapiens	216-232
12450894-9	2002	In women, tHcy was positively related to age (P = 0.001), apolipoprotein B (P &lt; 0.01), serum triacylglycerol (P &lt; 0.01), fasting glucose (P = 0.02), and coffee and alcohol consumption (both P &lt; 0.01) and inversely related to RBCF (P = 0.11) and plasma vitamin B-12 (P = 0.08) and vitamin B-6 (P = 0.01) intakes.	thcy	10-14	apolipoprotein B	Homo sapiens	58-74
12187113-6	2002	We observed a significant relationship between MTHFR genotypes and total plasma homocysteine (tHcy), as well as folate concentration.	thcy	94-98	methylenetetrahydrofolate reductase	Homo sapiens	47-52
12407634-8	2002	RESULTS: Plasma tHcy and sulfate concentrations in the groups with mRF and sRF were greater than in the HC group.	thcy	16-20	myelin regulatory factor	Mus musculus	67-70
12407634-8	2002	RESULTS: Plasma tHcy and sulfate concentrations in the groups with mRF and sRF were greater than in the HC group.	thcy	16-20	serum response factor	Homo sapiens	75-78
12161055-8	2002	Partial correlation analyses of CRP and IL6 with other variables showed significant correlation of CRP with tHcy, and SA in patients with CHD only.	thcy	108-112	interleukin 6	Homo sapiens	40-43
12161055-8	2002	Partial correlation analyses of CRP and IL6 with other variables showed significant correlation of CRP with tHcy, and SA in patients with CHD only.	thcy	108-112	C-reactive protein	Homo sapiens	99-102
12325051-9	2002	The distribution of the two common polymorphisms of the methylenetetrahydrofolate reductase gene (C677T and A1298C) was similar in patients with elevated and normal plasma tHcy.	thcy	172-176	methylenetetrahydrofolate reductase	Homo sapiens	56-91
12370840-2	2002	The aim of this study was to determine whether there is a correlation between increased total homocysteine (tHCY) and high Lp(a) concentrations, and whether increased concentrations of tHCY affect the concentration of unbound serum apolipoprotein(a) [Apo(a)].	thcy	185-189	lipoprotein(a)	Homo sapiens	232-249
12198008-11	2002	CONCLUSIONS: This study refutes the previous explanations for the reduction in plasma tHcy known to occur in pregnancy, namely, folic acid supplementation, hemodilution, and a decrease in serum albumin.	thcy	86-90	albumin	Homo sapiens	194-201
12200798-10	2002	Malnutrition and hypoalbuminemia were associated with low plasma sAA levels (tHcy, Met, and Tau); tCys was related to s-albumin level, but not SGNA score.	thcy	77-81	serum amyloid A1 cluster	Homo sapiens	65-68
12200798-14	2002	Malnutrition, hypoalbuminemia, and DM in patients with CRF influence sAA levels, mainly plasma tHcy, which should be considered when evaluating hyperhomocysteinemia as a cardiovascular risk factor.	thcy	95-99	serum amyloid A1 cluster	Homo sapiens	69-72
12217808-7	2002	PML-tHCy was similar in men and women.	thcy	4-8	PML nuclear body scaffold	Homo sapiens	0-3
12217808-8	2002	PML-tHCy was negatively correlated with folate in both sexes, and with vitamin B12 and age in women only.	thcy	4-8	PML nuclear body scaffold	Homo sapiens	0-3
12217808-9	2002	Folate accounted for 20% of the variance of PML-tHCy in men, while in women vitamin B12 and PLP explained 40% and 20% of variance of PML-tHCy, respectively.	thcy	48-52	PML nuclear body scaffold	Homo sapiens	44-47
12217808-9	2002	Folate accounted for 20% of the variance of PML-tHCy in men, while in women vitamin B12 and PLP explained 40% and 20% of variance of PML-tHCy, respectively.	thcy	137-141	proteolipid protein 1	Homo sapiens	92-95
12217808-9	2002	Folate accounted for 20% of the variance of PML-tHCy in men, while in women vitamin B12 and PLP explained 40% and 20% of variance of PML-tHCy, respectively.	thcy	137-141	PML nuclear body scaffold	Homo sapiens	133-136
12451194-10	2002	More research is needed to determine factors that aid in selecting patients for tHcy testing and improving diagnostic yield.	thcy	80-84	activation induced cytidine deaminase	Homo sapiens	50-53
12370840-8	2002	Backward multiple linear regression analysis, however, revealed that only post-load tHCY was independently and significantly influenced by Lp(a).	thcy	84-88	lipoprotein(a)	Homo sapiens	139-144
12370840-9	2002	Furthermore, Lp(a) correlated significantly with post-load tHCY, but not with fasting tHCY.	thcy	59-63	lipoprotein(a)	Homo sapiens	13-18
12370840-10	2002	Subdividing the subjects according to the Lp(a) concentration showed a significantly higher median concentration of tHCY after methionine load in subjects with Lp(a) over 50 mg/dL compared to subjects with Lp(a) under 50 mg/dL (P =.009).	thcy	116-120	lipoprotein(a)	Homo sapiens	42-47
12370840-10	2002	Subdividing the subjects according to the Lp(a) concentration showed a significantly higher median concentration of tHCY after methionine load in subjects with Lp(a) over 50 mg/dL compared to subjects with Lp(a) under 50 mg/dL (P =.009).	thcy	116-120	lipoprotein(a)	Homo sapiens	160-165
12370840-10	2002	Subdividing the subjects according to the Lp(a) concentration showed a significantly higher median concentration of tHCY after methionine load in subjects with Lp(a) over 50 mg/dL compared to subjects with Lp(a) under 50 mg/dL (P =.009).	thcy	116-120	lipoprotein(a)	Homo sapiens	160-165
12198008-9	2002	Mean reductions from preconception concentrations at 8, 20, and 32 wk of pregnancy were significantly greater (P &lt; 0.001) for tHcy (-11.5%, -25.5%, and -24.5%, respectively) than for hematocrit (-1.9%, -4.2%, and -4.3%, respectively) or serum albumin (-1.1%, -9.8%, and -13.4%, respectively).	thcy	129-133	albumin	Homo sapiens	246-253
12198222-3	2002	The data dealing with the possible regulation of the tHcy metabolism by insulin and nutritional status is conflicting in non-transplant populations.	thcy	53-57	insulin	Homo sapiens	72-79
12198222-9	2002	There was a positive relationship between tHcy and LDL-cholesterol (r=0.34, P=0.03) and a significant negative correlation between tHcy and insulin (r=-0.38, P=0.01).	thcy	131-135	insulin	Homo sapiens	140-147
12198222-10	2002	Fasting tHcy concentrations were significantly higher in the lower quartile of insulin concentration than in the upper quartile (27.7+/-12.7 vs 15.9+/-9.5, P=0.01).	thcy	8-12	insulin	Homo sapiens	79-86
12198222-11	2002	In multivariate analysis, tHcy was associated with serum creatinine (P=0.001), insulin (P=0.02) and folate concentration (P=0.03).	thcy	26-30	insulin	Homo sapiens	79-86
12198222-12	2002	Patients with the highest IGF-1 concentration had lower tHcy than patients with the lowest IGF-1 concentration (16.8+/-5.7 vs 23.3+/-11 micro mol/l, P=0.01).	thcy	56-60	insulin like growth factor 1	Homo sapiens	26-31
12198222-13	2002	CONCLUSION: We observed an inverse relationship between insulin and tHcy in chronic, stable RTR.	thcy	68-72	insulin	Homo sapiens	56-63
12489820-3	2002	However, not much information is available describing plasma tHcy levels and their relationship to plasma folate and vitamin B12 status in Koreans.	thcy	61-65	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	125-128
12145019-2	2002	A reduction in MTHFR activity, as occurs in the homozygous state for the 677C--&gt;T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy).	thcy	201-205	methylenetetrahydrofolate reductase	Homo sapiens	15-20
12145019-10	2002	CONCLUSIONS: The high tHcy concentration typically associated with homozygosity for the 677C--&gt;T variant of MTHFR occurs only with poor riboflavin status.	thcy	22-26	methylenetetrahydrofolate reductase	Homo sapiens	111-116
12135600-11	2002	In summary, fenofibrate increases serum tHcy in rodents in a PPARalpha-dependent manner.	thcy	40-44	peroxisome proliferator activated receptor alpha	Rattus norvegicus	61-70
12489820-13	2002	Plasma tHcy levels were related with inversely plasma concentrations of folate (r = -0.37249, p &lt; 0.001) as well as vitamin B12 (r = -0.22560, p &lt; 0.01) in both sexes.	thcy	7-11	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	127-130
12489820-16	2002	And improving folate and vitamin B12 status may reduce plasma tHcy level, which may be more important in males.	thcy	62-66	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
12034688-13	2002	In addition, among patients with ocular BD, the mean tHcy levels were significantly increased and correlated with ET-1 and NO levels when compared with non-ocular disease and control subjects.	thcy	53-57	endothelin 1	Homo sapiens	114-118
12421498-1	2002	OBJECTIVE: To study the influence of mutation of 677 C to T in the methylenetetrahydrofolate reductase (MTHFR) gene on the plasma total homocysteine (tHcy) levels in hemodialysis patients.	thcy	150-154	methylenetetrahydrofolate reductase	Homo sapiens	67-102
12421498-1	2002	OBJECTIVE: To study the influence of mutation of 677 C to T in the methylenetetrahydrofolate reductase (MTHFR) gene on the plasma total homocysteine (tHcy) levels in hemodialysis patients.	thcy	150-154	methylenetetrahydrofolate reductase	Homo sapiens	104-109
12175091-11	2002	Positive correlations were noted between tHcy and Cys C levels in normoalbuminuric and microalbuminuric diabetics (r = 0.72, r = 0.64, respectively).	thcy	41-45	cystatin C	Homo sapiens	50-55
27264762-6	2002	Two hour postload tHCy, expressed both as absolute value (PML) and as the difference between 2 hour postload tHCy and FtHCy (delta tHCy) was negatively correlated with folate in both sexes, and with vitamin B12 and age in women only.	thcy	18-22	PML nuclear body scaffold	Homo sapiens	58-61
12195398-12	2002	dose of folinic acid and vitamin B12, show significantly lower plasma levels of tHcy than non-supplemented patients.	thcy	80-84	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	33-36
12042673-2	2002	In this study, we investigated whether a second common polymorphism of the gene, MTHFR 1298A&gt;C, is an independent risk factor for colorectal cancer and if it is associated with plasma folate and total homocysteine (tHcy) levels.	thcy	218-222	methylenetetrahydrofolate reductase	Homo sapiens	81-86
11961021-8	2002	Independent predictors of tHcy plasma levels were serum albumin, alpha-EGR, red blood cell folate, and certain MTHFR genotypes.	thcy	26-30	methylenetetrahydrofolate reductase	Homo sapiens	111-116
11961021-9	2002	A logistic regression analysis showed that the MTHFR genotype is a predictor for having a tHcy plasma concentration within the fourth quartile.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	47-52
11956665-9	2002	The sufficiently high dose of folate seems to be able to decrease plasma tHcy in all three individual MTHFR polymorphism groups, to almost the same post-treatment concentrations.	thcy	73-77	methylenetetrahydrofolate reductase	Homo sapiens	102-107
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	thcy	162-166	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	thcy	162-166	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	101-120
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	thcy	248-252	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	thcy	248-252	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	101-120
11943942-5	2002	Subjects with the MTHFR 677TT genotype showed higher levels of tHcy compared with the 677CC genotype in patients (P = 0.010) and in controls (P = 0.030).	thcy	63-67	methylenetetrahydrofolate reductase	Homo sapiens	18-23
11943942-7	2002	Although tHcy levels are significantly higher in those homozygous for the MTHFR C677T mutation, this genotype does not increase the thrombotic risk in our study population.	thcy	9-13	methylenetetrahydrofolate reductase	Homo sapiens	74-79
11872884-6	2002	Cases with tHcy concentration above the cutoff level of 12 micromol/L were significantly more represented in the group of patients with sCAD compared with control subjects (64% versus 13.9%; 95% CI, 2.25 to 44.23; P=0.003); a significant association between the MTHFR TT genotype and sCAD was also observed (36% versus 11.1%; 95% CI, 1.10 to 19.23; P=0.045).	thcy	11-15	methylenetetrahydrofolate reductase	Homo sapiens	262-267
12033523-3	2002	A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and selected life-style related factors.	thcy	158-162	methylenetetrahydrofolate reductase	Homo sapiens	182-222
12033523-3	2002	A cross-sectional study with a random sample of 455 Japanese rural residents aged 40-69 years was conducted in 2000 to investigate the associations of plasma tHcy concentration with 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and selected life-style related factors.	thcy	158-162	methylenetetrahydrofolate reductase	Homo sapiens	224-229
12033523-8	2002	A multivariate regression analysis revealed that serum folate, serum vitamin B12, and MTHFR genotype were independently associated with plasma tHcy.	thcy	143-147	methylenetetrahydrofolate reductase	Homo sapiens	86-91
12033523-9	2002	The inter-individual variance of plasma tHcy was more explained by serum folate and vitamin B12 than by MTHFR genotype.	thcy	40-44	methylenetetrahydrofolate reductase	Homo sapiens	104-109
11815318-2	2002	The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH(2)) (MTHFR) influences the tHcy concentration and the response to tHcy-lowering therapy.	thcy	112-116	methylenetetrahydrofolate reductase	Homo sapiens	90-95
11815318-2	2002	The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase (FADH(2)) (MTHFR) influences the tHcy concentration and the response to tHcy-lowering therapy.	thcy	151-155	methylenetetrahydrofolate reductase	Homo sapiens	90-95
11815318-7	2002	RESULTS: Changes in plasma tHcy concentration depended on the supplemented folate derivative and the MTHFR genotype.	thcy	27-31	methylenetetrahydrofolate reductase	Homo sapiens	101-106
11815318-12	2002	CONCLUSIONS: The response to tHcy-lowering therapy is influenced by MTHFR genotype.	thcy	29-33	methylenetetrahydrofolate reductase	Homo sapiens	68-73
11939486-4	2002	The patients with low-normal plasma tHcy concentration showed decreased concentrations of serum cystatin C and serum creatinine and increased concentrations of blood folate and serum cobalamin compared to the controls and to the patients with high plasma tHcy.	thcy	36-40	cystatin C	Homo sapiens	96-106
11939486-5	2002	There was a large overlap in cystatin C concentrations between patients with high and low-normal plasma tHcy.	thcy	104-108	cystatin C	Homo sapiens	29-39
11774112-2	2002	Vitamin B6 deficiency may result in high tHcy levels, especially after a methionine load (PML).	thcy	41-45	PML nuclear body scaffold	Homo sapiens	90-93
11774112-6	2002	We found vitamin B6 deficiency and high tHcy (fasting and PML) levels in all patients.	thcy	40-44	PML nuclear body scaffold	Homo sapiens	58-61
11774112-8	2002	Fasting and PML tHcy levels were partially resistant to vitamin B6 supplements, with different response patterns in HD patients and those with CRI.	thcy	16-20	PML nuclear body scaffold	Homo sapiens	12-15
11728978-9	2001	Analysis of the rate of decline in GFR and tertiles of tHcy and PAI-1 revealed that increasing levels of tHcy were correlated with a significantly faster decline in GFR (P = 0.025), whereas increasing levels of PAI-1 were not.	thcy	105-109	serpin family E member 1	Homo sapiens	64-69
12050947-6	2002	Stepwise multiple linear regression with MCV as dependent and GGT, B12, folate and tHcy as independent variables, respectively, revealed significant associations of MCV with GGT (B = 2.18, 95% CI 0.95-3.42, P = 0.001) and tHcy (B = 3.33, 95% CI 1.26-5.39, P = 0.002).	thcy	83-87	gamma-glutamyltransferase 1	Homo sapiens	174-177
12050947-6	2002	Stepwise multiple linear regression with MCV as dependent and GGT, B12, folate and tHcy as independent variables, respectively, revealed significant associations of MCV with GGT (B = 2.18, 95% CI 0.95-3.42, P = 0.001) and tHcy (B = 3.33, 95% CI 1.26-5.39, P = 0.002).	thcy	222-226	gamma-glutamyltransferase 1	Homo sapiens	174-177
12218258-6	2002	In the present study we investigated the association between plasma tHcy and C-reactive protein (CRP), a sensitive marker for inflammation, in psychogeriatric patients.	thcy	68-72	C-reactive protein	Homo sapiens	77-95
12218258-6	2002	In the present study we investigated the association between plasma tHcy and C-reactive protein (CRP), a sensitive marker for inflammation, in psychogeriatric patients.	thcy	68-72	C-reactive protein	Homo sapiens	97-100
12218258-10	2002	There was a significant correlation between plasma tHcy and serum CRP (rho = 0.19, p &lt; 0.05).	thcy	51-55	C-reactive protein	Homo sapiens	66-69
11705822-1	2001	BACKGROUND: Elevated plasma levels of total homocysteine (tHcy) before and after an oral methionine load (PML) are associated with an elevated risk of deep-vein thrombosis (DVT).	thcy	58-62	PML nuclear body scaffold	Homo sapiens	106-109
11705822-5	2001	The ORs for DVT associated with high (&gt;95th percentile) fasting levels and PML increases of tHcy were 2.1 (95% CI, 1.2 to 3.4) and 2.4 (95% CI, 1.5 to 3.9) after adjustment for established risk factors for DVT.	thcy	95-99	PML nuclear body scaffold	Homo sapiens	78-81
11705822-6	2001	Fasting plasma levels and PML increases in tHcy correlated negatively with vitamin levels.	thcy	43-47	PML nuclear body scaffold	Homo sapiens	26-29
11705822-9	2001	CONCLUSIONS: High fasting and PML tHcy and low vitamin B(6) plasma levels are associated with an elevated risk for DVT independently of established risk factors for DVT.	thcy	34-38	PML nuclear body scaffold	Homo sapiens	30-33
11583719-7	2001	Plasma tHcy and mtDNA content have an independent effect on each other and on insulin resistance (HOMA-insulin resistance (IR) score) respectively in multiple regression model.	thcy	7-11	insulin	Homo sapiens	78-85
11684547-1	2001	The prevalence of the methionine synthase (MTR) 2756A--&gt;G polymorphism among individuals with severely elevated total homocysteine (tHcy) plasma levels is unknown.	thcy	135-139	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	22-41
11684547-5	2001	Conversely, combined MTR and MTHFR genotypes (MTR 2756AG and 2756GG and MTHFR 677TT/1298AA and 677CT/1298AC) were found more often in the highest (n = 34) compared with the lowest plasma tHcy decile (n = 19; P = 0.0252; OR, 1.983; 95% CI, 1.079 to 3.643).	thcy	187-191	methylenetetrahydrofolate reductase	Homo sapiens	29-34
11684547-7	2001	In summary, our study shows that the 2756A--&gt;G transition of MTR in combination with MTHFR 677TT/1298AA and 677CT/1298AC can be associated with extremely high tHcy plasma levels.	thcy	162-166	methylenetetrahydrofolate reductase	Homo sapiens	88-93
11583719-8	2001	Plasma tHcy showed positive correlations with age (r=0.407), W/H ratio (r=0.370), total cholesterol (r=0.338), LDL-cholesterol (r=0.317) and insulin resistance (HOMA-IR score) (r=0.261); and a negative correlation with folate (r=-0.273).	thcy	7-11	insulin	Homo sapiens	141-148
11568092-10	2001	CONCLUSIONS: The agreement between the TCEP and TBP methods was considerably lower for the determination of tCys, tCys-Gly, and tGSH than for tHcy.	thcy	142-146	TATA-box binding protein	Homo sapiens	48-51
11584084-8	2001	The subjects carrying the G2756 allele of the MS gene (n = 15) had a more extensive reduction (P &lt; 0.05) of plasma tHcy during the high folate diet period than the subjects with the genotype A/A (n = 22).	thcy	118-122	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	46-48
11592443-7	2001	Hence, it seems likely that serum-albumin is a strong determinant of plasma tHcy in CRF patients and this may contribute to the lower tHcy levels in malnourished patients.	thcy	76-80	albumin	Homo sapiens	28-41
11592443-7	2001	Hence, it seems likely that serum-albumin is a strong determinant of plasma tHcy in CRF patients and this may contribute to the lower tHcy levels in malnourished patients.	thcy	134-138	albumin	Homo sapiens	28-41
11592445-6	2001	Folate, Cystatin C and creatinine were significantly correlated to tHcy, while no correlation was found between tHcy, albumin and C-reactive protein.	thcy	67-71	cystatin C	Homo sapiens	8-18
11431185-4	2001	Multiple stepwise regression analysis showed that the MTHFR 677C--&gt;T/1298A--&gt;C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B(12) plasma level were significant predictors of tHcy plasma levels.	thcy	225-229	methylenetetrahydrofolate reductase	Homo sapiens	54-59
11592445-8	2001	The MTHFR 677TT genotype was less frequent and was associated with a significantly higher tHcy level in patients.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	4-9
11592445-9	2001	Folate and residual glomerular filtration estimated by cystatin C and creatinine levels were two independent determinants of tHcy in ESRD patients.	thcy	125-129	cystatin C	Homo sapiens	55-65
11445284-3	2001	S-adenosylmethionine (SAM), which is synthesized from adenosine triphosphate and methionine (MET), serves as methyl donor for this O-metabolisation of levodopa with resulting conversion of SAM to total homocysteine (tHcy) via S-adenosylhomocysteine (SAH).	thcy	216-220	SAFB like transcription modulator	Homo sapiens	93-96
11472746-10	2001	This study provides the first evidence that the MTRR A66G polymorphism significantly influences the circulating tHcy concentration.	thcy	112-116	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	48-52
11431185-5	2001	Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes.	thcy	67-71	methylenetetrahydrofolate reductase	Homo sapiens	48-53
11431185-5	2001	Analysis of variance showed that this effect of MTHFR genotypes on tHcy level was caused by significantly greater tHcy levels in 677TT/1298AA hemodialysis and peritoneal dialysis patients versus other genotypes.	thcy	114-118	methylenetetrahydrofolate reductase	Homo sapiens	48-53
11431185-8	2001	This study shows that the MTHFR 677TT/1298AA genotype, but not the 677CT/1298AC genotype, is a significant predictor of tHcy plasma levels in dialysis patients.	thcy	120-124	methylenetetrahydrofolate reductase	Homo sapiens	26-31
11466665-6	2001	RESULTS: General linear regression model including age, gender, vitamin status, and measurements of renal function showed that cystatin C and folate were independent predictors of tHcy levels.	thcy	180-184	cystatin C	Homo sapiens	127-137
11464234-2	2001	Blood total homocysteine concentration (tHcy) is considered to be the product of an interaction between genetic and nutritional factors notably intake of folate, vitamin B12 and pyridoxine.	thcy	40-44	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	170-173
11466665-9	2001	CONCLUSION: Both cystatin C and folate status were major independent determinants of fasting tHcy levels in the subgroup of Korean RTR with normal SCr.	thcy	93-97	cystatin C	Homo sapiens	17-27
11398138-16	2001	The following contributions to the variation of tHcy were seen in a multivariate regression model: plasma cobalamin (11%), creatinine (11%), plasma folate (8%), fat-free mass (5%), estradiol (2%), MTHFR polymorphisms (2%), and plasma protein (1%).	thcy	48-52	methylenetetrahydrofolate reductase	Homo sapiens	197-202
11401933-10	2001	In a multiple logistic regression model adjusted for tHcy, the association of PLP with CRP remained highly significant (P=0.003).	thcy	53-57	C-reactive protein	Homo sapiens	87-90
11328204-7	2001	Fasting and 6 h-PML p-tHcy concentrations were significantly higher in the patients than in the controls (P=0.03 and P=0.0001, respectively).	thcy	22-26	PML nuclear body scaffold	Homo sapiens	16-19
11289481-6	2001	On simple regression analyses, log tHcy correlated with insulin sensitivity indexes (r = -0.319, P = 0.005) as well as creatinine clearance (r = 0.634, P &lt; 0.0001) in all patients with diabetes.	thcy	35-39	insulin	Homo sapiens	56-63
11273876-6	2001	Normalization of tHcy plasma levels was dependent on a lower baseline tHcy level (P: = 0.01976), younger age (P: = 0.00896), and MTHFR 677TT/1298AA or 677CT/1298AC genotypes (P: = 0.00208 and P: = 0.02320, respectively).	thcy	17-21	methylenetetrahydrofolate reductase	Homo sapiens	129-134
11334318-12	2001	The best fitted model equation was log tHcy = 108.53 + 0.1606 (duration of dialysis) -1.1053 (s-F) -0.7980 (age) 0.0215 (vitamin B12).	thcy	39-43	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	129-132
11334318-14	2001	Despite the large number of PD patients with normal serum vitamin B12 and folate status, the relation between tHcy and vitamin B12 or folate suggests that the supplementation of these vitamins could be useful irrespective of their serum levels, especially in younger patients or in those treated for a long period of time with peritoneal dialysis.	thcy	110-114	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	127-130
11330536-8	2001	Fasting tHcy levels correlated well with PAI-1 (r=0.65; P&lt;0.0001) but not with Cy levels (r=0.10; P=0.4).	thcy	8-12	serpin family E member 1	Homo sapiens	41-46
11330536-9	2001	The prevalence of the MTHFR 677TT genotype in renal transplant recipients was not significantly higher in patients than in controls (mutant allele frequency: 0.48 in patients and 0.47 in controls) and was associated with significantly higher fasting and postmethionine tHcy levels both in controls and patients.	thcy	269-273	methylenetetrahydrofolate reductase	Homo sapiens	22-27
11330536-11	2001	Patients with the MTHFR 677TT genotype had the major percentage of decrease of tHcy levels with respect to the other genotypes.	thcy	79-83	methylenetetrahydrofolate reductase	Homo sapiens	18-23
11289481-7	2001	Multiple regression analyses showed that insulin sensitivity indexes (beta = -0.245) as well as creatinine clearance were independent contributors to log tHcy in all patients with diabetes (R2 = 0.750, P &lt; 0.0001).	thcy	154-158	insulin	Homo sapiens	41-48
11289481-8	2001	For the 59 patients with diabetes with creatinine clearance &gt;60 ml/min, insulin sensitivity indexes were also shown to be a significant contributor to log tHcy (beta = -0.438, R2 = 0.561, P &lt; 0.001).	thcy	158-162	insulin	Homo sapiens	75-82
11289481-9	2001	CONCLUSION: Insulin resistance and renal function are independent determinants of tHcy levels in patients with type 2 diabetes.	thcy	82-86	insulin	Homo sapiens	12-19
11266032-1	2001	OBJECTIVE: The authors found considerably lower plasma total homocysteine (tHcy) concentrations in patients with end-stage renal disease (ESRD) on maintenance hemodialysis, who routinely received high-dose parenteral vitamin B12, than in comparable patients receiving much higher doses of folic acid but only replacement-dose oral vitamin B12.	thcy	75-79	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	225-228
11257268-2	2001	Functional genetic variants of the MS may alter total homocysteine (tHcy) as well as folate levels which are independent risk factors for vascular disease.	thcy	68-72	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	35-37
11257268-3	2001	The influence of a common genetic polymorphism (2756A--&gt;G, D919G) of the MS gene on plasma tHcy and folate levels and its relation to the risk of myocardial infarction (MI) in a prospective study of male physicians in the US was investigated.	thcy	94-98	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	76-78
11257268-8	2001	The MS polymorphism was associated with decreased tHcy (10.55, 9.87 and 9.57 nmol/ml for DD, DG and GG genotypes, respectively) and increased folate levels (3.95, 3.78, 7.31 ng/ml for DD, DG and GG genotypes, respectively) only among controls but not cases.	thcy	50-54	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	4-6
11257268-9	2001	It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies.	thcy	77-81	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	39-41
11464650-1	2001	UNLABELLED: Hyperhomocysteinemia is an independent risk factor for cardiovascular mortality in ESRD, but about 80% of total homocysteine (tHcy) is bound to albumin (alb).	thcy	138-142	albumin	Homo sapiens	156-159
11266032-11	2001	CONCLUSIONS: Three monthly vitamin B12 injections modestly but distinctly reduced tHcy concentrations in hemodialysis patients whose prior vitamin B12 status was normal.	thcy	82-86	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	35-38
11133719-2	2001	A thermolabile form of a pivotal enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase (MTHFR), has been associated with vascular occlusive disease and raised tHcy levels.	thcy	176-180	methylenetetrahydrofolate reductase	Homo sapiens	68-103
11169020-12	2001	The mean percentage (%) reductions (+/- 95% confidence interval) in tHcy were as follows: RTR 28.1% (16.2 to 40.0%); HD 12.1% (6.6 to 17.7%, P = 0.027 for comparison of between groups differences by analysis of covariance adjusted for baseline tHcy levels).	thcy	68-72	nuclear receptor subfamily 6 group A member 1	Homo sapiens	90-93
11169021-1	2001	BACKGROUND: The total homocysteine (tHcy) plasma level, which is partly determined by the MTHFR 677C--&gt;T genotype, may be associated with vascular disease.	thcy	36-40	methylenetetrahydrofolate reductase	Homo sapiens	90-95
11133719-2	2001	A thermolabile form of a pivotal enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase (MTHFR), has been associated with vascular occlusive disease and raised tHcy levels.	thcy	176-180	methylenetetrahydrofolate reductase	Homo sapiens	105-110
11427458-2	2001	Preliminary studies in a small number of these individuals have shown that serum creatinine and cystatin C, both markers of kidney function and glomerular filtration rate, are independent determinants of fasting tHcy concentrations; however, determinants of tHcy concentrations after a methionine load have not been studied.	thcy	212-216	cystatin C	Homo sapiens	96-106
11427458-6	2001	Unadjusted Pearson correlations showed that fasting plasma tHcy correlated with both cystatin C (r = 0.564; P &lt;0.001) and creatinine (r = 0.519; P &lt;0.001) and that increases in PML tHcy modestly correlated with cystatin (r = 0.205; P = 0.072), but not creatinine (r = 0.057; P = 0.624).	thcy	59-63	cystatin C	Homo sapiens	85-95
11427458-7	2001	General linear regression modeling with stepwise analysis of covariance showed that both cystatin C (partial R = 0.554; P &lt;0.001) and creatinine (partial R = 0.535; P &lt;0.001) were independent predictors of fasting tHcy, but of the two, only cystatin C (partial R = 0.242; P = 0.035) was an independent predictor of increased PML tHcy.	thcy	220-224	cystatin C	Homo sapiens	89-99
11427458-7	2001	General linear regression modeling with stepwise analysis of covariance showed that both cystatin C (partial R = 0.554; P &lt;0.001) and creatinine (partial R = 0.535; P &lt;0.001) were independent predictors of fasting tHcy, but of the two, only cystatin C (partial R = 0.242; P = 0.035) was an independent predictor of increased PML tHcy.	thcy	335-339	cystatin C	Homo sapiens	89-99
11427458-9	2001	Both creatinine and cystatin C are independent predictors of fasting tHcy in these individuals; however, only cystatin C is a determinant of tHcy concentration after a methionine load, probably because cystatin C is a more sensitive marker of glomerular filtration rate than serum creatinine.	thcy	141-145	cystatin C	Homo sapiens	110-120
11427458-9	2001	Both creatinine and cystatin C are independent predictors of fasting tHcy in these individuals; however, only cystatin C is a determinant of tHcy concentration after a methionine load, probably because cystatin C is a more sensitive marker of glomerular filtration rate than serum creatinine.	thcy	141-145	cystatin C	Homo sapiens	110-120
11057853-6	2000	When adjusted for determinants of hyperhomocysteinemia in the patient and the control populations (generalized linear model), fasting tHcy levels were significantly higher in subjects with association of the two gene abnormalities (24.2+/-3.8 micromol/L) than in subjects with the MTHFR 677TT mutation only (14.0+/-5.8 micromol/L, p = 0.004).	thcy	134-138	methylenetetrahydrofolate reductase	Homo sapiens	281-286
11149614-3	2000	We studied 1,055 individuals with respect to the effect of two silent polymorphisms, the 699C--&gt; T and the 1080C--&gt;T, of the cystathionine beta-synthase (CBS) gene on plasma tHcy levels.	thcy	180-184	cystathionine beta-synthase	Homo sapiens	160-163
11004224-5	2000	MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P &lt; 0.	thcy	73-77	methylenetetrahydrofolate reductase	Homo sapiens	0-5
11004224-5	2000	MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P &lt; 0.	thcy	73-77	methylenetetrahydrofolate reductase	Homo sapiens	109-114
11004224-5	2000	MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P &lt; 0.	thcy	86-90	methylenetetrahydrofolate reductase	Homo sapiens	0-5
11004224-5	2000	MTHFR genotype and all other variables were significant predictors of ln-tHcy (higher tHcy plasma levels for MTHFR 677TT/1298AA versus all other five genotype groups: P &lt; 0.	thcy	86-90	methylenetetrahydrofolate reductase	Homo sapiens	109-114
11186895-11	2000	The two other prevalent genotypes, 16/17 and 17/18, are associated with significantly decreased tHcy levels as compared to the 17/ 17 genotype, suggesting that the 16 and 18 repeats haplotype may be in linkage disequilibrium with regulatory elements which upregulate CBS gene transcription.	thcy	96-100	cystathionine beta-synthase	Homo sapiens	267-270
11177206-2	2000	The aim of the present study was to determine the impact of this MTHFR common mutation on plasma and erythrocyte folate (RCF) and plasma total homocysteine (tHcy) concentrations in healthy French adults.	thcy	157-161	methylenetetrahydrofolate reductase	Homo sapiens	65-70
11054348-2	2000	Considering that Cys is mainly synthesized from Hcy, a common C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene may affect the serum total Cys (tCys) concentration, as well as total Hcy (tHcy) concentration, through reduced remethylation of Hcy to methionine, even in hemodialysis patients.	thcy	208-212	methylenetetrahydrofolate reductase	Homo sapiens	84-119
11054348-2	2000	Considering that Cys is mainly synthesized from Hcy, a common C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene may affect the serum total Cys (tCys) concentration, as well as total Hcy (tHcy) concentration, through reduced remethylation of Hcy to methionine, even in hemodialysis patients.	thcy	208-212	methylenetetrahydrofolate reductase	Homo sapiens	121-126
11054348-5	2000	Slopes of regression lines relating tHcy and tCys concentrations differed between the MTHFR genotypes, and the relationship was strengthened with a decreasing number of T alleles.	thcy	36-40	methylenetetrahydrofolate reductase	Homo sapiens	86-91
11092508-1	2000	Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --&gt; T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease.	thcy	179-183	methylenetetrahydrofolate reductase	Homo sapiens	39-74
11092508-1	2000	Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --&gt; T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease.	thcy	179-183	methylenetetrahydrofolate reductase	Homo sapiens	76-81
11092508-8	2000	These data suggest that older women who are homozygous for the MTHFR 677C --&gt; T mutation may be at risk for greater elevations in plasma tHcy in response to moderately low folate intake as compared with individuals with the normal or heterozygous genotypes.	thcy	140-144	methylenetetrahydrofolate reductase	Homo sapiens	63-68
11004224-9	2000	In a prespecified subgroup analysis (n = 496), the MTHFR genotype also influenced tHcy levels and compound heterozygous patients had significantly lower folate levels as compared with MTHFR 677CC/1298AA and 677CC/1298CC.	thcy	82-86	methylenetetrahydrofolate reductase	Homo sapiens	51-56
11004224-10	2000	This study shows that the MTHFR 677TT/1298AA and 677CT/1298AC genotypes are significant predictors of tHcy and folate plasma levels.	thcy	102-106	methylenetetrahydrofolate reductase	Homo sapiens	26-31
10780318-7	2000	tHcy was negatively correlated to folate and vitamin B12 levels, with better correlation found in subjects with the 677TT mutation (r = -0.42 and -0.25) than with the 677CC or CT MTHFR genotype (r = 0).37 and -0.11).	thcy	0-4	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	53-56
10982535-12	2000	Homozygosity for the MTHFR variant was weakly predictive of tHCY levels but not mortality.	thcy	60-64	methylenetetrahydrofolate reductase	Homo sapiens	21-26
10982535-13	2000	CONCLUSIONS: In patients with angiographically defined CAD, tHCY is a significant predictor of mortality, independent of traditional risk factors, CRP, and MTHFR genotype.	thcy	60-64	C-reactive protein	Homo sapiens	147-150
10998075-2	2000	The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade inflammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively.	thcy	53-57	vascular cell adhesion molecule 1	Homo sapiens	248-281
10998075-2	2000	The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade inflammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively.	thcy	53-57	C-reactive protein	Homo sapiens	296-314
10998075-2	2000	The aim of this study was firstly to examine whether tHcy is associated with endothelial dysfunction, increased adherence of leukocytes, and/or chronic low-grade inflammation, as estimated from plasma levels of von Willebrand factor (vWf), soluble vascular cell adhesion molecule 1 (sVCAM-1) and C-reactive protein (CRP), respectively.	thcy	53-57	C-reactive protein	Homo sapiens	316-319
10998075-5	2000	Linear regression analyses were used to study whether tHcy was associated with vWf, sVCAM-1 and CRP, and whether the presence of diabetes modified these associations.	thcy	54-58	von Willebrand factor	Homo sapiens	79-82
10998075-6	2000	RESULTS: After adjustment for confounders, tHcy was significantly but weakly associated with vWf (beta = 0.15, P = 0.05) and sVCAM-1 (beta = 0.082, P = 0.04).	thcy	43-47	von Willebrand factor	Homo sapiens	93-96
10998075-9	2000	CONCLUSIONS: This study provides evidence that tHcy is, at most, weakly associated with endothelial dysfunction as estimated from plasma vWf, and with leukocyte adhesion as estimated from plasma sVCAM-1.	thcy	47-51	von Willebrand factor	Homo sapiens	137-140
10794752-7	2000	Plasma tHcy correlated with severity of dementia (r = 0.36; P &lt;0.01), the Katz ADL index (r = 0.29; P &lt;0.05), the Berger scale (r = 0.29; P &lt;0.05), and the score of symptoms (r = 0.39; P &lt;0.001) in the psychogeriatric population.	thcy	7-11	sarcoglycan alpha	Homo sapiens	82-85
10770516-5	2000	RESULTS: The patients on AEDs inducing the cytochrome P450 (carbamazepine, phenytoin, phenobarbital, primidone), had higher fasting and 6h-PML plasma tHcy concentrations than the controls (P = 0.01 and P&lt;0.001).	thcy	150-154	PML nuclear body scaffold	Homo sapiens	139-142
10770516-7	2000	CONCLUSIONS: Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs.	thcy	69-73	PML nuclear body scaffold	Homo sapiens	65-68
10760109-7	2000	The tHcy levels were positively correlated with SAlb, Met, tCys, and SCr.	thcy	4-8	albumin	Homo sapiens	48-52
10919921-8	2000	4) The C677T transition of the methylenetetrahydrofolate reductase gene causes a moderate increase in tHcy but no or only minor increased CVD risk.	thcy	102-106	methylenetetrahydrofolate reductase	Homo sapiens	31-66
10926884-9	2000	The riboflavin-tHcy relationship was modified by genotype (P = 0.004) and was essentially confined to subjects with the C677T transition of the MTHFR gene.	thcy	15-19	methylenetetrahydrofolate reductase	Homo sapiens	144-149
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	thcy	203-207	cystathionine beta-synthase	Homo sapiens	57-84
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	thcy	203-207	cystathionine beta-synthase	Homo sapiens	86-89
10780318-10	2000	A 4-week administration of 5-methyltetrahydrofolate (15 mg/day) markedly lowered plasma tHcy in 24 patients with MTHFR 677TT genotype, but the response to treatment correlated with vitamin B,2 levels (p = 0.023).	thcy	88-92	methylenetetrahydrofolate reductase	Homo sapiens	113-118
10780318-7	2000	tHcy was negatively correlated to folate and vitamin B12 levels, with better correlation found in subjects with the 677TT mutation (r = -0.42 and -0.25) than with the 677CC or CT MTHFR genotype (r = 0).37 and -0.11).	thcy	0-4	methylenetetrahydrofolate reductase	Homo sapiens	179-184
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	thcy	55-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	103-106
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	thcy	55-59	methylenetetrahydrofolate reductase	Homo sapiens	119-124
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	thcy	55-59	methylenetetrahydrofolate reductase	Homo sapiens	173-178
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	thcy	55-59	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	248-251
10780318-9	2000	In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p &lt; or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p &lt; or =0.028).	thcy	55-59	methylenetetrahydrofolate reductase	Homo sapiens	173-178
10653487-8	2000	Moreover, a significant correlation was demonstrated between plasma GSHPx activity, plasma glutathione peroxidase protein and plasma tHcy.	thcy	133-137	glutathione peroxidase 3	Homo sapiens	84-113
10669648-1	2000	A biochemical link between homocysteine (tHcy) and lipoprotein(a) [Lp(a)] related to fibrin binding has been proposed.	thcy	41-45	lipoprotein(a)	Homo sapiens	51-65
10669648-1	2000	A biochemical link between homocysteine (tHcy) and lipoprotein(a) [Lp(a)] related to fibrin binding has been proposed.	thcy	41-45	lipoprotein(a)	Homo sapiens	67-72
10653487-7	2000	The activity of erythrocyte superoxide dismutase (SOD) and plasma glutathione peroxidase (GSHPx) was elevated in samples with plasma tHcy &gt; 20 microM.	thcy	133-137	glutathione peroxidase 3	Homo sapiens	59-88
11112046-9	2000	Finally, we found a significant correlation between tHcy and PAI-1 plasma levels (r = 0.76; P &lt; 0.000001).	thcy	52-56	serpin family E member 1	Homo sapiens	61-66
10692093-9	2000	RESULTS: The results demonstrated a significant negative correlation between plasma tHcy levels and insulin levels at the second visit.	thcy	84-88	insulin	Homo sapiens	100-107
10692093-13	2000	However, negative association between insulin levels and tHcy concentrations was found.	thcy	57-61	insulin	Homo sapiens	38-45
10901625-3	2000	Fasting tHcy (IGT, 13.1 +/- 4.6; T2D, 12.8 +/- 4.0; NGT, 10.7 +/- 4.4 micromol/L) and PML-tHcy (IGT, 46.5 +/-17.39; T2D, 41.1 +/- 6.8; NGT, 38.0 +/- 9.7 micromol/L) showed no differences between the groups.	thcy	90-94	PML nuclear body scaffold	Homo sapiens	86-89
10901625-4	2000	Fasting tHcy and PML-tHcy correlated with fasting proinsulin (r = 0.395, p &lt; 0.05; r = 0.386, p&lt; 0.05) and creatinine (r = 0.489, p &lt; 0.01; r = 0.339, p &lt; 0.05), resp.	thcy	8-12	insulin	Homo sapiens	50-60
10901625-4	2000	Fasting tHcy and PML-tHcy correlated with fasting proinsulin (r = 0.395, p &lt; 0.05; r = 0.386, p&lt; 0.05) and creatinine (r = 0.489, p &lt; 0.01; r = 0.339, p &lt; 0.05), resp.	thcy	21-25	PML nuclear body scaffold	Homo sapiens	17-20
10901625-4	2000	Fasting tHcy and PML-tHcy correlated with fasting proinsulin (r = 0.395, p &lt; 0.05; r = 0.386, p&lt; 0.05) and creatinine (r = 0.489, p &lt; 0.01; r = 0.339, p &lt; 0.05), resp.	thcy	21-25	insulin	Homo sapiens	50-60
11860891-10	2000	CONCLUSIONS: Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR.	thcy	32-36	methylenetetrahydrofolate reductase	Homo sapiens	123-128
11860891-11	2000	Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR.	thcy	81-85	methylenetetrahydrofolate reductase	Homo sapiens	102-107
11860891-7	2000	Mean plasma tHcy for thermolabile homozygous mutation of MTHFR was significantly higher than that for either heterozygous mutation or wild homozygous mutation (P &lt; 0.001).	thcy	12-16	methylenetetrahydrofolate reductase	Homo sapiens	57-62
10430785-8	1999	After adjustment for possible confounders, a 1 micromol/L increase in tHcy was associated with an increase in ET of 0.08 ng/L (P = 0.045) and an increase in vWF of 4.2% (P = 0.05).	thcy	70-74	von Willebrand factor	Homo sapiens	157-160
11860891-9	2000	Plasma tHcy was slightly greater in those with lower serum folate than in those with higher one, and correlated inversely with activity of MTHFR.	thcy	7-11	methylenetetrahydrofolate reductase	Homo sapiens	139-144
11860891-10	2000	CONCLUSIONS: Increase in plasma tHcy correlates with homozygous mutation of thermolabile MTHFR and decrease in activity of MTHFR.	thcy	32-36	methylenetetrahydrofolate reductase	Homo sapiens	89-94
10563175-3	1999	A frequent mutation (C677T) in the gene coding for the enzyme methyltetrahydrofolate reductase (MTHFR) is often associated with elevated values of tHcy.	thcy	147-151	methylenetetrahydrofolate reductase	Homo sapiens	62-94
10563175-3	1999	A frequent mutation (C677T) in the gene coding for the enzyme methyltetrahydrofolate reductase (MTHFR) is often associated with elevated values of tHcy.	thcy	147-151	methylenetetrahydrofolate reductase	Homo sapiens	96-101
10318658-3	1999	We also examined whether vitamin cofactors and the C677T genetic mutation of the methylenetetrahydrofolate reductase (MTHFR) enzyme were major contributors to elevated plasma tHcy and carotid vascular disease.	thcy	175-179	methylenetetrahydrofolate reductase	Homo sapiens	118-123
10459572-4	1999	The homozygosity for the 677 C --&gt; T mutation of MTHFR was associated with elevated tHcy and low folate levels.	thcy	87-91	methylenetetrahydrofolate reductase	Homo sapiens	52-57
10444346-4	1999	In the current investigation, we studied 741 individuals with respect to the effect of the 68-bp insertion of the CBS gene on fasting and PML tHcy, and also determined the level of pyridoxal-5"-phosphate (vitamin B(6)), a cofactor of the CBS enzyme.	thcy	142-146	cystathionine beta-synthase	Homo sapiens	114-117
10397696-4	1999	Therefore, we evaluated plasma total homocysteine (tHcy), folate, and vitamin B12 levels and established, by polymerase chain reaction, the presence of the C677T mutation (A223V) in the methylenetetrahydrofolate reductase (MTHFR) gene in 220 cases with VTE without well-established prothrombotic defects.	thcy	51-55	methylenetetrahydrofolate reductase	Homo sapiens	186-221
10318658-8	1999	Serum and dietary folate levels and the C677T mutation in MTHFR were independent determinants of tHcy (all P=0.0001).	thcy	97-101	methylenetetrahydrofolate reductase	Homo sapiens	58-63
10229730-3	1999	The main objectives of this study of young ischemic stroke patients were (1) to examine fasting and post-methionine load levels of tHcy, (2) to ascertain the genotype frequency of the C677CT mutation in the methylenetetrahydrofolate reductase gene (TT genotype), and (3) to study the possible interaction between plasma tHcy levels and fibrinolytic factors.	thcy	320-324	methylenetetrahydrofolate reductase	Homo sapiens	207-242
10323785-4	1999	We focused on tHcy levels in relation to levels of vitamin B12, B6 and folate and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.	thcy	14-18	methylenetetrahydrofolate reductase	Homo sapiens	86-121
10323785-4	1999	We focused on tHcy levels in relation to levels of vitamin B12, B6 and folate and the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.	thcy	14-18	methylenetetrahydrofolate reductase	Homo sapiens	123-128
10323785-5	1999	Multivariate linear analyses adjusted for the presence of vascular disease showed that fasting tHcy was significantly related to folate and vitamin B12, and the presence of the MTHFR TT genotype and the T allele, and to age, smoking habits, and serum levels of creatinine.	thcy	95-99	methylenetetrahydrofolate reductase	Homo sapiens	177-182
10323785-6	1999	Both post-methionine and delta tHcy levels were related to serum folate levels, and the presence of the MTHFR TT genotype and the T allele, and to postmenopausal status, and body mass index.	thcy	31-35	methylenetetrahydrofolate reductase	Homo sapiens	104-109
10323785-11	1999	We also found evidence, in patients with premature vascular disease but not in their healthy siblings, for a factor that increases tHcy levels but weakens the normal inverse relation between folate and tHcy and amplifies the effect of the MTHFR genotype.	thcy	131-135	methylenetetrahydrofolate reductase	Homo sapiens	239-244
10337865-7	1999	The extent of the plasma tHcy reduction tended to be influenced by the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR).	thcy	25-29	methylenetetrahydrofolate reductase	Homo sapiens	93-128
10337865-7	1999	The extent of the plasma tHcy reduction tended to be influenced by the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR).	thcy	25-29	methylenetetrahydrofolate reductase	Homo sapiens	130-135
10052494-6	1999	RESULTS: tHcy (21.8+/-14.4 micromol/l) correlated significantly with Kt/V (r=0.32, P&lt;0.05), total Kt/V (r=0.29, P&lt;0.05), nPCR (r=0.30, P&lt;0.05) and serum concentrations of albumin (r=0.28, P&lt;0.05) and cobalamines (r=-0.27, P&lt;0.05).	thcy	9-13	nasopharyngeal carcinoma-related protein	Homo sapiens	127-131
9791839-1	1998	OBJECTIVES: To investigate the association of status of vitamins B6, B12 and folate with plasma fasting total homocysteine (tHcy) and with risk of coronary atherosclerosis; and to establish whether associations between vitamins and risk of coronary atherosclerosis are mediated by tHcy.	thcy	124-128	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	69-72
9823829-8	1998	The odds ratio of confirmed AD associated with a tHcy level in the top third (> or = 14 micromol/L) compared with the bottom third (< or = 11 micromol/L) of the control distribution was 4.5 (95% confidence interval, 2.2-9.2), after adjustment for age, sex, social class, cigarette smoking, and apolipoprotein E epsilon4.	thcy	49-53	apolipoprotein E	Homo sapiens	294-319
9791839-7	1998	RESULTS: Cases who were in the upper quartile of serum vitamin B12 and erythrocyte folate concentrations showed statistically significantly lower tHcy concentrations (-4.00 and -4.71 mumol/L, respectively) than those in the lowest quartile.	thcy	146-150	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	63-66
9791839-13	1998	Low vitamin B12 concentrations were associated with an increased risk of coronary atherosclerosis, partly independently of tHcy.	thcy	123-127	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	12-15
9361025-1	1997	Cystathionine beta-synthase (CBS) deficiency is an autosomal recessive disorder which results in extremely elevated levels of total plasma homocysteine (tHcy) and high risk of thromboembolic events.	thcy	153-157	cystathionine beta-synthase	Homo sapiens	0-27
9687553-11	1998	This effect was most distinct in women with the highest tHcy concentrations at baseline and in women homozygous for the 677 C--&gt;T mutation of the MTHFR-gene.	thcy	56-60	methylenetetrahydrofolate reductase	Homo sapiens	149-154
9596662-8	1998	A genotype/phenotype correlation study showed a marked effect of folate on the association between MTHFR genotypes and tHcy.	thcy	119-123	methylenetetrahydrofolate reductase	Homo sapiens	99-104
9550566-6	1998	Median tHcy concentrations were approximately 1 micromol/L higher in men than in women and in older (70 to 74 years) than in younger (65 to 69 years) individuals and higher in those with the TT and CT genotypes for the methylenetetrahydrofolate reductase polymorphism than in those with the CC genotype (10.7 and 10.6 vs 9.6 micromol/L).	thcy	7-11	methylenetetrahydrofolate reductase	Homo sapiens	219-254
9681281-1	1998	A polymorphism associated with a thermolabile variant (C677T) of the enzyme methylenetetrahydrofolate reductase has been associated with both elevated total homocysteine (tHcy) levels and risk for cardiovascular disease.	thcy	171-175	methylenetetrahydrofolate reductase	Homo sapiens	76-111
9323065-4	1997	We conducted a cross-sectional analysis of demographics, the diet, tHcy level, presence of the C677T mutation in the methylenetetrahydrofolate reductase gene (a common genetic cause of elevated tHcy) in children, and the prevalence of parental CVD.	thcy	194-198	methylenetetrahydrofolate reductase	Homo sapiens	117-152
9347290-6	1997	RESULTS: Significant cross-sectional relationships, both univariate and multivariate were found between tHcy and index concentrations of folate and vitamin B12 (P &lt; 0.0001), and between tHcy and plasma creatinine, urea, calcium, zinc, alpha 1-antichymotrypsin, lutein and cysteine (P = 0.013 to &lt; 0.0001).	thcy	104-108	serpin family A member 3	Homo sapiens	238-262
9323065-7	1997	tHcy was increased in children whose parent with FH had experienced CVD compared with children without parental CVD (median [interquartile range], 6.6 [5.3, 8.0] micromol/L versus 5.6 [4.7, 6.8] micromol/L; P=.01).	thcy	0-4	low density lipoprotein receptor	Homo sapiens	49-51
9323065-10	1997	CONCLUSIONS: These findings suggest that a moderately elevated tHcy level may partly account for the contribution of the family history to risk of CVD in FH.	thcy	63-67	low density lipoprotein receptor	Homo sapiens	154-156
9244205-8	1997	Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes.	thcy	107-111	methylenetetrahydrofolate reductase	Homo sapiens	54-59
9258413-6	1997	Basal tHcy was lower in those with high levels of serum folate, red cell folate and serum B12; they also showed a greater percentage rise with loading.	thcy	6-10	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	90-93
9264011-2	1997	Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR).	thcy	29-33	methylenetetrahydrofolate reductase	Homo sapiens	151-186
9264011-2	1997	Elevated total homocysteine (tHcy) plasma levels can results from defective remethylation of Hcy to methionine due to decreased activity of the enzyme methylenetetrahydrofolate reductase (MTHFR).	thcy	29-33	methylenetetrahydrofolate reductase	Homo sapiens	188-193
9264011-4	1997	We tested the hypothesis that elevation of tHcy plasma levels in hemodialysis patients is influenced by the 677 C to T mutation of the MTHFR gene and examined the relation of the genotype with tHcy, folate and vitamin B12 plasma levels in these patients.	thcy	43-47	methylenetetrahydrofolate reductase	Homo sapiens	135-140
9247365-1	1997	Homozygosity for a 677C--&gt;T mutation at the locus that codes for 5,10-methylenetetrahydrofolate reductase (MTHFR), a folate-dependent crucial enzyme in homocysteine metabolism, may render the enzyme thermolabile and less active and has been associated with increased levels of plasma total homocysteine (tHcy).	thcy	307-311	methylenetetrahydrofolate reductase	Homo sapiens	68-108
9244205-11	1997	Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population.	thcy	68-72	methylenetetrahydrofolate reductase	Homo sapiens	26-31
34496965-7	2021	At univariate analysis resistin levels were significantly associated with age, waist circumference, hypertension, tHcy, hsPCR, sVCAM, IL-6, HDL-cholesterol, triglycerides and creatinine levels, but only creatinine, triglycerides, hsCRP, IL-6 and sVCAM were independently associated to resistin levels at stepwise regression analysis.	thcy	114-118	resistin	Homo sapiens	23-31
9247365-1	1997	Homozygosity for a 677C--&gt;T mutation at the locus that codes for 5,10-methylenetetrahydrofolate reductase (MTHFR), a folate-dependent crucial enzyme in homocysteine metabolism, may render the enzyme thermolabile and less active and has been associated with increased levels of plasma total homocysteine (tHcy).	thcy	307-311	methylenetetrahydrofolate reductase	Homo sapiens	110-115
9247365-10	1997	Our study indicates that homozygosity for the 677C--&gt;T MTHFR mutation, especially in combination with low folate status, predisposes to high plasma levels of fasting tHcy.	thcy	169-173	methylenetetrahydrofolate reductase	Homo sapiens	58-63
8873653-4	1996	A point mutation (C677T) in the gene encoding methylenetetrahydrofolate reductase, an enzyme involved in homocysteine remethylation, has been reported to render the enzyme thermolabile and less active and has been associated with elevated tHcy in homozygous carriers (+/+ genotype) as well as with increased risk of premature cardiovascular disease.	thcy	239-243	methylenetetrahydrofolate reductase	Homo sapiens	46-81
34707639-0	2021	Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population.	thcy	157-161	methylenetetrahydrofolate reductase	Homo sapiens	77-82
34707639-4	2021	The ExWAS identified two loci, 1p36.22 (lead single-nucleotide polymorphism (SNP) rs1801133, MTHFR C677T) and 16q24.3 (rs1126464, DPEP1), showing exome-wide significant association with tHCY (p < 5E-7); and both loci have been previously associated with tHCY in non-East Asian populations.	thcy	186-190	methylenetetrahydrofolate reductase	Homo sapiens	93-98
34707639-4	2021	The ExWAS identified two loci, 1p36.22 (lead single-nucleotide polymorphism (SNP) rs1801133, MTHFR C677T) and 16q24.3 (rs1126464, DPEP1), showing exome-wide significant association with tHCY (p < 5E-7); and both loci have been previously associated with tHCY in non-East Asian populations.	thcy	186-190	dipeptidase 1	Homo sapiens	130-135
34528713-1	2021	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of sulfur metabolism characterized by elevated blood levels of total homocysteine (tHcy).	thcy	156-160	cystathionine beta-synthase	Mus musculus	0-27
34769882-6	2021	Cotinine, creatinine, methylmalonic acid, and the methylenetetrahydrofolate reductase genotype (MTHFR) T allele were positively associated with tHcy among the smokers, but not among the snus users.	thcy	144-148	probable methylenetetrahydrofolate reductase	Nicotiana tabacum	50-85
35351068-8	2022	ApoE rs429358 and rs7412 variants were observed to have the highest serum TC and TG level in the subjects with high serum tHcy level (p <  0.05).	thcy	122-126	apolipoprotein E	Homo sapiens	0-4
33949005-2	2021	Loss of CBS activity due to mutation results in CBS deficiency, an inborn error of metabolism characterized by extreme elevation of plasma total homocysteine (tHcy).	thcy	159-163	cystathionine beta-synthase	Mus musculus	8-11
33949005-4	2021	However, adult Cbs null mice that express a hypomorphic allele of human CBS as a transgene (Tg-I278T Cbs-/- ) show almost no neonatal lethality despite having serum tHcy levels similar to mice with no CBS activity.	thcy	165-169	cystathionine beta-synthase	Homo sapiens	72-75
35420248-10	2022	There was a statistically significant positive correlation between serum tHcy and D-dimer, ferritin, alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), and a highly significant positive correlation between tHcy and CO-RADS score, PICU admission, and the disease severity classification.	thcy	73-77	solute carrier family 17 member 5	Homo sapiens	153-156
35351068-10	2022	Independent of age, BMI, education levels, smoking and alcohol drinking, the worst cognitive ability were detected in the high serum tHcy level subjects with ApoE rs429358C/T and rs7412 C/T as compare with other groups, especially orientation function, memory and delayed recall ability and attention ability.	thcy	133-137	apolipoprotein E	Homo sapiens	158-162
33504456-10	2021	Strong positive correlations existed for HE4 with both tHcy and creatinine.	thcy	55-59	WAP four-disulfide core domain 2	Homo sapiens	41-44
33922851-6	2021	The PAI-1 675 4G/5G gene polymorphisms were significantly correlated with increased homocysteine level (tHcy) (p < 0.05), higher total cholesterol (TC) (p < 0.05), low- density lipoprotein cholesterol (LDLc) (p = 0.05) and high- sensitive C- reactive protein (hsCRP) (p < 0.05) in patients with CVST when compared with controls.	thcy	104-108	serpin family E member 1	Homo sapiens	4-9
32992197-10	2020	Higher plasma tHcy level was also associated with number of CMBs, TT MTHFR genotype, and lower MMSE scores.	thcy	14-18	methylenetetrahydrofolate reductase	Homo sapiens	69-74
33375456-12	2020	The MTHFR polymorphism was significantly correlated with higher total cholesterol (TC) (p = 0.023), low- density lipoprotein cholesterol (LDL) (p = 0.008), homocysteine level (tHcy) (p < 0.001).	thcy	176-180	methylenetetrahydrofolate reductase	Homo sapiens	4-9
32992197-12	2020	Lowering plasma tHcy could be helpful in cognitively impaired patients who have CMBs or the MTHFR TT genotype.	thcy	16-20	methylenetetrahydrofolate reductase	Homo sapiens	92-97
31084364-1	2019	Cystathionine beta-synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by extremely elevated total homocysteine (tHcy) in the blood.	thcy	143-147	cystathionine beta-synthase	Mus musculus	0-27
32629650-4	2020	Fasting c-peptide and creatinine were independently associated with tHcy levels in patients aged >=60 years, whereas insulin and creatinine were independently associated with tHcy levels in those aged >=75 years.tHcy concentrations were elevated in T2DM and can potentially serve as a risk factor for DKD, but it is not an ideal biomarker.	thcy	68-72	insulin	Homo sapiens	8-17
32629650-4	2020	Fasting c-peptide and creatinine were independently associated with tHcy levels in patients aged >=60 years, whereas insulin and creatinine were independently associated with tHcy levels in those aged >=75 years.tHcy concentrations were elevated in T2DM and can potentially serve as a risk factor for DKD, but it is not an ideal biomarker.	thcy	175-179	insulin	Homo sapiens	117-124
32629650-4	2020	Fasting c-peptide and creatinine were independently associated with tHcy levels in patients aged >=60 years, whereas insulin and creatinine were independently associated with tHcy levels in those aged >=75 years.tHcy concentrations were elevated in T2DM and can potentially serve as a risk factor for DKD, but it is not an ideal biomarker.	thcy	175-179	insulin	Homo sapiens	117-124
32299541-1	2020	Objective To investigate the association between total homocysteine (tHcy) level in plasma and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genetic polymorphisms in a Chinese Han nationality population with type 2 diabetes mellitus (T2DM) accompanied by dyslipidemia.	thcy	69-73	methylenetetrahydrofolate reductase	Homo sapiens	95-130
32299541-1	2020	Objective To investigate the association between total homocysteine (tHcy) level in plasma and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C genetic polymorphisms in a Chinese Han nationality population with type 2 diabetes mellitus (T2DM) accompanied by dyslipidemia.	thcy	69-73	methylenetetrahydrofolate reductase	Homo sapiens	132-137
32299541-8	2020	There was a significant correlation between tHcy level and MTHFR C677T gene polymorphism in T2DM patients (t=2.27, P=0.02).	thcy	44-48	methylenetetrahydrofolate reductase	Homo sapiens	59-64
32299541-10	2020	Conclusion MTHFR 677TT genotype might associate with higher tHcy level in T2DM patients with dyslipidemia.	thcy	60-64	methylenetetrahydrofolate reductase	Homo sapiens	11-16
32127061-6	2020	Medical history and lifestyle habits were recorded.Principal tHcy determinants differed between women (age, plasma folate, plasma cobalamin, cigarettes/day) and men (MTHFR 677TT genotype, plasma folate, plasma cobalamin and CT genotype).	thcy	61-65	methylenetetrahydrofolate reductase	Homo sapiens	166-171
32127061-7	2020	The MTHFR 677C>T polymorphism-tHcy association (beta standardised regression coefficients) was stronger in male smokers (0.52, P < 0.001) compared to nonsmokers (0.21, P = 0.001) and weaker in participants >50 (0.19, P = 0.007) compared to <=50 years (0.31, P < 0.001).	thcy	30-34	methylenetetrahydrofolate reductase	Homo sapiens	4-9
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	thcy	92-96	cystathionine beta-synthase	Mus musculus	22-25
31240737-5	2019	Zinc-treated Tg-R336C Cbs -/- mice have extreme elevation in both serum total homocysteine (tHcy) and liver tHcy compared with control transgenic mice.	thcy	108-112	cystathionine beta-synthase	Mus musculus	22-25
31044529-7	2020	However, blood tHcy concentrations differed in the PEMT genotype subgroups when choline and folate intakes were considered: respectively, 25% and 20% lower levels were observed in the C allele carriers who met their needs of choline or folate than in those who did not take enough these nutrients (P &lt; 0.05 for both associations).	thcy	15-19	phosphatidylethanolamine N-methyltransferase	Homo sapiens	51-55
31044529-8	2020	CONCLUSIONS: This study suggests that choline and folate intakes might interact with MTHFR, BHMT and PEMT polymorphisms to determine tHcy and GSH blood concentrations in healthy pregnant women.	thcy	133-137	methylenetetrahydrofolate reductase	Homo sapiens	85-90
31044529-8	2020	CONCLUSIONS: This study suggests that choline and folate intakes might interact with MTHFR, BHMT and PEMT polymorphisms to determine tHcy and GSH blood concentrations in healthy pregnant women.	thcy	133-137	betaine--homocysteine S-methyltransferase	Homo sapiens	92-96
31044529-8	2020	CONCLUSIONS: This study suggests that choline and folate intakes might interact with MTHFR, BHMT and PEMT polymorphisms to determine tHcy and GSH blood concentrations in healthy pregnant women.	thcy	133-137	phosphatidylethanolamine N-methyltransferase	Homo sapiens	101-105
30080444-2	2019	Previously, it has been shown that the common c.677C &gt; T polymorphism in MTHFR influences global DNA methylation status through a direct interaction with folate status and (indirectly) with total homocysteine (tHcy) levels.	thcy	213-217	methylenetetrahydrofolate reductase	Homo sapiens	76-81
31269488-4	2019	Compared with participants with severe damage (GCS &lt;9), those with mild damage (GCS &gt;=13) had significantly lower transformed tHcy levels (beta = -2.46; 95% CI -4.80 to -0.12).	thcy	132-136	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	145-154
31269488-5	2019	Consistently, a significantly lower transformed tHcy levels were found in participants with mild damage (GCS &gt;=13; beta = -1.37; 95% CI -2.66 to -0.08) compared with those with moderate to severe damage (GCS &lt;13).	thcy	48-52	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	118-127
30646578-4	2019	A common mutation (1364T/T) of the cystathionine-gamma-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD.	thcy	211-215	cystathionine gamma-lyase	Homo sapiens	35-60
30646578-4	2019	A common mutation (1364T/T) of the cystathionine-gamma-lyase (CTH) gene affects the enzyme that converts cystathionine to cysteine in the transsulfuration pathway causing plasma elevation of total homocysteine (tHcy) or hyperhomocysteinemia-a strong and independent risk factor for cognitive loss and AD.	thcy	211-215	cystathionine gamma-lyase	Homo sapiens	62-65
30401001-5	2018	The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status.	thcy	14-18	methylenetetrahydrofolate reductase	Homo sapiens	120-125
30958356-6	2019	RESULTS: We found significant interactions between omega3-FA supplementation and tHcy on cognition and clinical stage assessed by MMSE (p = 0.040), global CDR (p = 0.059), and CDRsob (p = 0.023), but not on ADAS-cog (p = 0.649).	thcy	81-85	alkylglycerone phosphate synthase	Homo sapiens	207-211
29306994-12	2018	Both maternal holoTC and tHcy may assist in predicting infantile cbl status.	thcy	25-29	Cbl proto-oncogene	Homo sapiens	65-68
30014716-7	2018	Plasma tHcy was higher among participants in the upper versus lower Vit-A tertile.	thcy	7-11	vitrin	Homo sapiens	68-71
30014716-10	2018	When we stratified the population according to Vit-A tertiles, plasma tHcy was associated with acute myocardial infarction only in the upper Vit-A tertile (hazard ratio per SD: 1.25, 95% confidence interval: 1.04-1.53, pinteraction = 0.03).	thcy	70-74	vitrin	Homo sapiens	47-50
30014716-10	2018	When we stratified the population according to Vit-A tertiles, plasma tHcy was associated with acute myocardial infarction only in the upper Vit-A tertile (hazard ratio per SD: 1.25, 95% confidence interval: 1.04-1.53, pinteraction = 0.03).	thcy	70-74	vitrin	Homo sapiens	141-144
30014716-11	2018	Conclusions The risk relationship between plasma tHcy and acute myocardial infarction was modified by serum concentrations of Vit-A in patients with suspected stable angina pectoris.	thcy	49-53	vitrin	Homo sapiens	126-129
29813097-1	2018	AIMS: To study how MTHFR 677C T genotype modulates the effect of supplementation with B-vitamins on total homocysteine (tHcy) and B-vitamin concentrations.	thcy	120-124	methylenetetrahydrofolate reductase	Homo sapiens	19-24
29306994-9	2018	In the correlational analysis between maternal and infantile markers associated with cbl status, the strongest correlation was observed between maternal holoTC and infantile tHcy (r = -0.49, p &lt; 0.001), followed by the correlation between maternal tHcy and infantile tHcy (r = 0.47, p &lt; 0.001).	thcy	174-178	Cbl proto-oncogene	Homo sapiens	85-88
28741220-9	2018	Patients with severe head injury, acute SDH, or diffuse higher radiological grades had greater levels of tHcy compared to others.	thcy	105-109	serine dehydratase	Homo sapiens	40-43
29722849-1	2018	Background: The single nucleotide polymorphism of the gene 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (or rs1801133) is the most established genetic factor that increases plasma total homocysteine (tHcy) and consequently results in hyperhomocysteinemia.	thcy	210-214	methylenetetrahydrofolate reductase	Homo sapiens	59-99
29722849-1	2018	Background: The single nucleotide polymorphism of the gene 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T (or rs1801133) is the most established genetic factor that increases plasma total homocysteine (tHcy) and consequently results in hyperhomocysteinemia.	thcy	210-214	methylenetetrahydrofolate reductase	Homo sapiens	101-106
29444504-12	2018	In addition, patients carrying the MTHFR rs915014 AG or GG genotypes were associated with accumulation of circulating tHcy volume and a poor atherosclerosis consequence.	thcy	118-122	methylenetetrahydrofolate reductase	Homo sapiens	35-40
29371246-5	2018	More importantly, tHcy lowering varied by MTHFR genotypes and serum folate levels.	thcy	18-22	methylenetetrahydrofolate reductase	Homo sapiens	42-47
28963520-8	2017	In addition, the total homocysteine (tHcy) levels in subjects with MTHFR 2572AA were elevated compared to tHcy levels in subjects with MTHFR 2572CC.	thcy	37-41	methylenetetrahydrofolate reductase	Homo sapiens	67-72
29030456-10	2017	The beneficial effect associated with greater tHcy reduction was observed across strata for age, sex, treatment group (with vs without folic acid), MTHFR C677T genotypes, baseline tHcy and serum folate levels, and blood pressure control.	thcy	46-50	methylenetetrahydrofolate reductase	Homo sapiens	148-153
27591199-11	2018	In contrast, plasma tHcy concentrations were lower in sepsis patients compared to healthy control participants (4 [2-6]) vs 7 [5-9] muM; P = .04).	thcy	20-24	latexin	Homo sapiens	132-135
28381531-4	2017	Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees.	thcy	238-242	methylenetetrahydrofolate reductase	Homo sapiens	151-191
28598562-5	2017	Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T.	thcy	28-32	methylenetetrahydrofolate reductase	Homo sapiens	102-142
28598562-5	2017	Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T.	thcy	28-32	methylenetetrahydrofolate reductase	Homo sapiens	144-149
28598562-10	2017	Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	55-60
28968204-2	2017	COMT might affect tHcy levels because as a by-product it converts SAM to S-adenosylhomocysteine (SAH), which is reversibly converted to homocysteine.	thcy	18-22	catechol-O-methyltransferase	Homo sapiens	0-4
28381531-4	2017	Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees.	thcy	238-242	methylenetetrahydrofolate reductase	Homo sapiens	193-198
28381531-4	2017	Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees.	thcy	307-311	methylenetetrahydrofolate reductase	Homo sapiens	151-191
28381531-4	2017	Improvements in overall performance ranged from 4-fold for Hcy:Cys to ~8-fold for Hcy:Cys:Cre and were particularly strong in subjects with the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677CC genotype.Conclusions: Ratios of tHcy to tCys and/or creatinine showed a severalfold improvement over tHcy alone as functional markers of B-vitamin status in Norwegian coronary angiography screenees.	thcy	307-311	methylenetetrahydrofolate reductase	Homo sapiens	193-198
27356547-10	2017	On multiple regression analysis, elevated maternal total homocysteine (tHcy) levels adjusted for treatment group, birthweight, parity, income and home environment at second trimester of pregnancy were significantly negatively associated with expressive language (beta = 3.13 points, P &lt; 0.001), and in third trimester of pregnancy with expressive language (beta = -2.29 points, P &lt; 0.001) and fine motor (beta = -1.41 points, P = 0.005) domains of BSID-III.	thcy	71-75	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	360-369
27356547-10	2017	On multiple regression analysis, elevated maternal total homocysteine (tHcy) levels adjusted for treatment group, birthweight, parity, income and home environment at second trimester of pregnancy were significantly negatively associated with expressive language (beta = 3.13 points, P &lt; 0.001), and in third trimester of pregnancy with expressive language (beta = -2.29 points, P &lt; 0.001) and fine motor (beta = -1.41 points, P = 0.005) domains of BSID-III.	thcy	71-75	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	411-420
29188889-1	2017	BACKGROUND: Vitamin B12 status is measured by four plasma/ serum biomarkers: total vitamin B12 (total B12), holotranscobalamin (holoTC), methylmalonic acid (MMA) and homocysteine (tHcy).	thcy	180-184	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	20-23
28094233-8	2017	Individuals with the MTHFR TT genotype had significantly higher serum tHcy concentrations than individuals with the CC and CT genotypes (p&lt;0.001).	thcy	70-74	methylenetetrahydrofolate reductase	Homo sapiens	21-26
28094233-11	2017	CONCLUSION: The MTHFR C677T polymorphism, folate deficiency, and B12 deficiency were significantly associated with elevated serum tHcy levels.	thcy	130-134	methylenetetrahydrofolate reductase	Homo sapiens	16-21
28094233-13	2017	Thus, folic acid and vitamin B12 supplementation could help prevent diseases associated with tHcy accumulation, especially in individuals with the MTHFR 677TT genotype.	thcy	93-97	methylenetetrahydrofolate reductase	Homo sapiens	147-152
28171870-10	2017	In addition, patients carrying the MTHFR rs868014 TC or CC genotypes were associated with accumulation of serum tHcy and a poor ischemic stroke outcome.	thcy	112-116	methylenetetrahydrofolate reductase	Homo sapiens	35-40
28225483-9	2017	Potential effect modification by the MTHFR genotype on the relationship between tHcy and all-cause mortality was tested.	thcy	80-84	methylenetetrahydrofolate reductase	Homo sapiens	37-42
28225483-16	2017	Whereas the MTHFR genotype alone had little effect on mortality, it significantly modified the tHcy-mortality association, which was much stronger in the CC/CT genotype than in the TT genotype (P for interaction &lt; 0.05).	thcy	95-99	methylenetetrahydrofolate reductase	Homo sapiens	12-17
28225483-17	2017	CONCLUSIONS: Among Chinese hypertensive patients without cardiovascular comorbidities, elevated tHcy was a significant risk marker for death from all causes, and the association was subject to effect modification by MTHFR genotypes.	thcy	96-100	methylenetetrahydrofolate reductase	Homo sapiens	216-221
29188889-11	2017	Spline regression showed that levels of MMA and tHcy started to rise when vitamin B12 levels fall below 330 pmol/L and with HoloTC levels below 100 pmol/L, with a sharp increase with levels of B12 and HoloTC below 220 and 50 pmol/L respectively.	thcy	48-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	193-196
29188889-13	2017	The observed inflections for total B12 and holoTC with MMA and tHcy could indicate cut-off levels for further testing for B12 deficiency and determining subclinical B12 deficiency.	thcy	63-67	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	122-125
29188889-2	2017	Associations of B12 intake with holoTC and tHcy and associations between all four biomarkers have not been extensively studied.	thcy	43-47	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	16-19
29188889-8	2017	We explored the dose-response association between B12 intake and biomarkers and the association of total B12 and holoTC with tHcy and MMA with restricted cubic spline plots.	thcy	125-129	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	105-108
29188889-9	2017	RESULTS: A doubling of B12 intake was associated with 9% higher total B12, 15% higher HoloTC, 9% lower MMA and 2% lower tHcy.	thcy	120-124	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	23-26
29188889-11	2017	Spline regression showed that levels of MMA and tHcy started to rise when vitamin B12 levels fall below 330 pmol/L and with HoloTC levels below 100 pmol/L, with a sharp increase with levels of B12 and HoloTC below 220 and 50 pmol/L respectively.	thcy	48-52	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	82-85
26559681-3	2016	The aim of our study was to explore the response of tHcy in hemodialysis (HD) patients to individual supplementation with folic acid (B9) and/or vitamin B12, based on carrier status for the (MTHFR) polymorphism.	thcy	52-56	methylenetetrahydrofolate reductase	Homo sapiens	191-196
26559681-16	2016	CONCLUSION: Supplementation with B vitamins correlated to the MTHFR genotypes has been shown to lower significantly tHcy in HD patients.	thcy	116-120	methylenetetrahydrofolate reductase	Homo sapiens	62-67
27183385-5	2016	Here, we have shown that administration of PEGylated CBS into the circulation of homocystinuria model mice alters the extra- and intracellular equilibrium of sulfur amino acids, resulting in a decrease of approximately 75% in plasma total homocysteine (tHcy) and normalization of cysteine concentrations.	thcy	253-257	cystathionine beta-synthase	Mus musculus	53-56
28806886-1	2016	The aim of the present study is to evaluate the effect of the rs6586282 polymorphism of the cystathionine-beta-synthase (CBS) gene, and of the intake of B vitamins on anthropometric parameters, tHcy levels, and lipoprotein levels in women over 60 years of age.	thcy	194-198	cystathionine beta-synthase	Homo sapiens	121-124
26567910-8	2016	After adjustment [age, sex, SBP, smoking (in pack years), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and weight], eGFR and tHcy were independently associated with TPA (P &lt; 0.01), but when both were added to the model, their significance was attenuated (P = 0.06 for eGFR, 0.03 for tHcy).	thcy	142-146	epidermal growth factor receptor	Homo sapiens	288-292
26567910-8	2016	After adjustment [age, sex, SBP, smoking (in pack years), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and weight], eGFR and tHcy were independently associated with TPA (P &lt; 0.01), but when both were added to the model, their significance was attenuated (P = 0.06 for eGFR, 0.03 for tHcy).	thcy	303-307	epidermal growth factor receptor	Homo sapiens	133-137
26567910-9	2016	Mediation analysis showed that tHcy seems to contribute to a significant mediation of the association of eGFR with TPA but not stenosis; after adjustment for the set of risk factors listed above, tHcy still demonstrated significant mediation on TPA (P = 0.03), but not on stenosis (P = 0.16).	thcy	31-35	epidermal growth factor receptor	Homo sapiens	105-109
26750749-4	2016	This study investigated the prevalence of CBS mutations and the common methylenetetrahydrofolate reductase (MTHFR) c.677C&gt;T polymorphism in patients with tHcy &gt;= 50 muM and the association with clinical manifestations.	thcy	157-161	cystathionine beta-synthase	Homo sapiens	42-45
27293558-9	2016	Subjects with the methylenetetrahydrofolate reductase mutations CT and TT had 11 % (P &lt; 0 05) higher baseline tHcy concentrations than those with the wild-type CC.	thcy	113-117	methylenetetrahydrofolate reductase	Homo sapiens	18-53
27079234-4	2016	Here, we find patients with cerebral infarction had a higher TM methylation level than controls (74.2% vs 47.5%, X(2) = 14.724, P = 0.00), which are positively correlated with plasma levels of tHcy (r = 0.701, P = 0.00) and negatively related to mRNA expression of TM (r = -0.711, P = 0.00).	thcy	193-197	thrombomodulin	Homo sapiens	61-63
27079234-4	2016	Here, we find patients with cerebral infarction had a higher TM methylation level than controls (74.2% vs 47.5%, X(2) = 14.724, P = 0.00), which are positively correlated with plasma levels of tHcy (r = 0.701, P = 0.00) and negatively related to mRNA expression of TM (r = -0.711, P = 0.00).	thcy	193-197	thrombomodulin	Homo sapiens	265-267
26774227-9	2016	MTHFR C677T TT was associated with higher tHcy but did not affect cognitive performance per se.	thcy	42-46	methylenetetrahydrofolate reductase	Homo sapiens	0-5
26750749-4	2016	This study investigated the prevalence of CBS mutations and the common methylenetetrahydrofolate reductase (MTHFR) c.677C&gt;T polymorphism in patients with tHcy &gt;= 50 muM and the association with clinical manifestations.	thcy	157-161	methylenetetrahydrofolate reductase	Homo sapiens	71-106
26750749-12	2016	When tHcy is between 50 and 100 muM genotyping for the MTHFR(3) c.677TT is relevant, and when tHcy &gt;100 muM CBS should be genotyped.	thcy	5-9	methylenetetrahydrofolate reductase	Homo sapiens	55-60
26599618-2	2016	Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine.	thcy	120-124	cystathionine beta-synthase	Mus musculus	17-20
27051654-5	2016	MTHFR C677T polymorphism was genotyped by the polymerase chain reaction technique combined with restriction enzyme fragment length polymorphism (PCR-RFLP) technique and plasma total homocysteine (tHcy) levels were determined by enzyme immunoassay method.	thcy	196-200	methylenetetrahydrofolate reductase	Homo sapiens	0-5
27051654-12	2016	Also, MTHFR C677T polymorphism is not a risk factor for PVT but is a contributing factor for elevated plasma tHcy levels.	thcy	109-113	methylenetetrahydrofolate reductase	Homo sapiens	6-11
26725074-8	2016	In a multiple linear regression analysis, tHcy was a significant independent determinant of sCr and cystatin C in men (beta = 0.206 and beta = 0.282, respectively) and women (beta = 0.247 and beta = 0.229, respectively).	thcy	42-46	cystatin C	Homo sapiens	100-110
26725074-9	2016	Highest tHcy levels were independently associated with increased cystatin C (&gt;s1.10 mg/L) with an odds ratio (OR) of 5.00 [95% confidence interval (CI) 2.81-8.09] and decreased eGFR (&lt;90 mL/min/1.73 m(2)) with an OR of 1.69 (95% CI 1.36-2.11) compared to tHcy levels in the 1st-3rd quartiles.	thcy	8-12	cystatin C	Homo sapiens	65-75
26725074-9	2016	Highest tHcy levels were independently associated with increased cystatin C (&gt;s1.10 mg/L) with an odds ratio (OR) of 5.00 [95% confidence interval (CI) 2.81-8.09] and decreased eGFR (&lt;90 mL/min/1.73 m(2)) with an OR of 1.69 (95% CI 1.36-2.11) compared to tHcy levels in the 1st-3rd quartiles.	thcy	261-265	cystatin C	Homo sapiens	65-75
26725074-10	2016	CONCLUSIONS: Higher levels of tHcy are independently associated with sCr and cystatin C elevation.	thcy	30-34	cystatin C	Homo sapiens	77-87
26599618-5	2016	Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine.	thcy	91-95	cystathionine beta-synthase	Mus musculus	9-12
26689687-13	2015	Our data indicated that variants in MTHFR gene might individually and jointly influence susceptibility to ARC by affecting MTHFR enzyme activity and tHcy levels.	thcy	149-153	methylenetetrahydrofolate reductase	Homo sapiens	36-41
26231230-1	2016	Cystathionine beta synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by elevated serum total homocysteine (tHcy).	thcy	139-143	cystathionine beta-synthase	Mus musculus	0-27
26231230-5	2016	Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels.	thcy	116-120	cystathionine beta-synthase	Mus musculus	9-12
25787778-5	2015	Levels of tHcy were positively related to PWV measured 4-5 years later for participants with early-stage CKD (estimated glomerular filtration rate &lt;60 ml min(-1) per 1.73 m(2)).	thcy	10-14	CD59 molecule (CD59 blood group)	Homo sapiens	157-163
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	thcy	81-85	cystathionine beta-synthase	Homo sapiens	97-124
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	thcy	81-85	cystathionine beta-synthase	Homo sapiens	126-129
25516282-6	2015	We evaluated if the CBS carriers tend to have higher fasting serum tHcy concentrations than non-carriers in presence of folate deficiency.	thcy	67-71	cystathionine beta-synthase	Homo sapiens	20-23
25516282-8	2015	RESULTS: The serum tHcy level of the Tao CBS carriers (17.9 +- 3.8 mumol/l) was significantly higher than in Tao non-carriers (15.7 +- 3.5 mumol/l; p &lt; 0.008) and Taiwanese controls (11.8 +- 2.9 mumol/l; p &lt; 0.001).	thcy	19-23	cystathionine beta-synthase	Homo sapiens	41-44
25516282-12	2015	CONCLUSIONS: CBS carriers tend to have a higher tHcy level in the presence of folate deficiency than non-carriers.	thcy	48-52	cystathionine beta-synthase	Homo sapiens	13-16
25516282-14	2015	Owing to a significantly elevated level of fasting tHcy without methionine loading, it is important to evaluate the risk of cardiovascular disease in CBS carriers with folate deficiency.	thcy	51-55	cystathionine beta-synthase	Homo sapiens	150-153
25095762-3	2015	Vitamin B12 and folic acid supplementation have been reported to lower homocysteine (tHcy) levels, but no data on plasma tHcy, cysteine (Cys), folate and vitamin B12 levels in T2D-CKD patients are reported.	thcy	85-89	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	8-11
26719836-2	2015	The aim of the present study was to investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with plasma total homocysteine (tHcy) levels and DVT risk in an Iranian population.	thcy	167-171	methylenetetrahydrofolate reductase	Homo sapiens	72-107
26719836-2	2015	The aim of the present study was to investigate the correlation between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with plasma total homocysteine (tHcy) levels and DVT risk in an Iranian population.	thcy	167-171	methylenetetrahydrofolate reductase	Homo sapiens	109-114
26719836-6	2015	Also, plasma tHcy levels were significantly higher in MTHFR 677TT genotypes compared to 677CC genotypes in both DVT patients (P=0.016) and controls (P=0.03).	thcy	13-17	methylenetetrahydrofolate reductase	Homo sapiens	54-59
26719836-11	2015	Also, MTHFR 677TT genotype is a determinant of elevated plasma tHcy levels.	thcy	63-67	methylenetetrahydrofolate reductase	Homo sapiens	6-11
25762406-9	2015	The cblC defect can be screened by measuring propionylcarnitine, propionylcarnitine-to-acetylcarnitine ratio combined with the second tier markers methylmalonic acid and tHcy.	thcy	170-174	Cbl proto-oncogene C	Homo sapiens	4-8
25401978-4	2014	RESULTS: In multiple linear regression analysis, baseline tHcy levels associated with age, BMI, SBP, DBP, LDL-C and Cr independently over 4.8-years follow-up; age, BMI, SBP, DBP and Cr were found to be associated with tHcy levels independently at the end of follow-up.	thcy	58-62	selenium binding protein 1	Homo sapiens	96-99
24732583-1	2015	The aim of this paper was to summarize the present evidence for an association between circulating total homocysteine (tHcy) levels and abdominal aortic aneurysm (AAA) presence, we performed a meta-analysis.	thcy	119-123	AAA1	Homo sapiens	163-166
24732583-4	2015	Eligible studies were case-control or population-screening studies reporting circulating tHcy levels in cases with AAA and subjects without AAA.	thcy	89-93	AAA1	Homo sapiens	115-118
24732583-8	2015	A pooled analysis demonstrated significantly greater circulating tHcy levels in the AAA than control group (SMD, 0.58; 95% CI, 0.36 to 0.79; P&lt;0.00001).	thcy	65-69	AAA1	Homo sapiens	84-87
24732583-10	2015	In conclusion, greater circulating tHcy levels are associated with AAA presence.	thcy	35-39	AAA1	Homo sapiens	67-70
25841618-8	2015	The risk of failure in tHcy level normalization was increased in patients with metabolic syndrome (hazard ratio [HR], 3.49; 95% confidence interval [CI], 1.46-8.36), higher baseline tHcy levels (HR, 1.045; 95% CI, 1.018-1.073), or methylenetetrahydrofolate reductase homozygous mutation (HR, 6.59; 95% CI, 2.64-16.4).	thcy	23-27	methylenetetrahydrofolate reductase	Homo sapiens	231-266
25401978-4	2014	RESULTS: In multiple linear regression analysis, baseline tHcy levels associated with age, BMI, SBP, DBP, LDL-C and Cr independently over 4.8-years follow-up; age, BMI, SBP, DBP and Cr were found to be associated with tHcy levels independently at the end of follow-up.	thcy	58-62	D-box binding PAR bZIP transcription factor	Homo sapiens	101-104
25401978-4	2014	RESULTS: In multiple linear regression analysis, baseline tHcy levels associated with age, BMI, SBP, DBP, LDL-C and Cr independently over 4.8-years follow-up; age, BMI, SBP, DBP and Cr were found to be associated with tHcy levels independently at the end of follow-up.	thcy	58-62	selenium binding protein 1	Homo sapiens	169-172
25401978-4	2014	RESULTS: In multiple linear regression analysis, baseline tHcy levels associated with age, BMI, SBP, DBP, LDL-C and Cr independently over 4.8-years follow-up; age, BMI, SBP, DBP and Cr were found to be associated with tHcy levels independently at the end of follow-up.	thcy	58-62	D-box binding PAR bZIP transcription factor	Homo sapiens	174-177
25322900-4	2014	MTHFR 677T allele carriers with middle or low tertile plasma folate (&lt;14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p &lt; 0.01).	thcy	103-107	methylenetetrahydrofolate reductase	Homo sapiens	0-5
25322900-6	2014	In the lowest cobalamin quartile (&lt;=273 pmol/L), riboflavin status modifies the relationship between the MTRR 66 A&gt;G polymorphism and tHcy (p for interaction: 0.034).	thcy	140-144	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	108-112
25322900-7	2014	tHcy was 6.6 % higher in MTRR 66G allele carriers compared to the 66AA genotype with marginally deficient or optimal riboflavin status, but there was no difference when riboflavin status was deficient (p for interaction: 0.059).	thcy	0-4	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	25-29
25322900-8	2014	tHcy was 13.7 % higher in MTRR 524T allele carriers compared to the 524CC genotype when cobalamin status was low (p &lt; 0.01), but no difference was observed when we stratified by riboflavin status.	thcy	0-4	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	26-30
25322900-9	2014	The effect of the MTHFR 677C&gt;T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A&gt;G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C&gt;T polymorphism on cobalamin status.	thcy	50-54	methylenetetrahydrofolate reductase	Homo sapiens	18-23
25322900-9	2014	The effect of the MTHFR 677C&gt;T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A&gt;G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C&gt;T polymorphism on cobalamin status.	thcy	50-54	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Homo sapiens	175-179
25176448-3	2014	The MTHFR 677T-allele was associated with increased tHcy concentrations only in males (P=0.005).	thcy	52-56	methylenetetrahydrofolate reductase	Serinus canaria	4-9
25176448-4	2014	The MTHFR 1298C-allele was found to be associated with higher tHcy levels but similarly, only in males (P=0.025).	thcy	62-66	methylenetetrahydrofolate reductase	Serinus canaria	4-9
25176448-5	2014	The MTHFR 1793A-allele was associated with decreased tHcy concentrations in the younger males (P=0.042).	thcy	53-57	methylenetetrahydrofolate reductase	Serinus canaria	4-9
25176448-6	2014	A haplotype-based approach was marginally superior in explaining the genetic interaction of the MTHFR polymorphisms on tHcy plasma levels (R2 0.352 vs. 0.342 for a simple genotype-based approach).	thcy	119-123	methylenetetrahydrofolate reductase	Serinus canaria	96-101
25176448-7	2014	A nutrigenetic interaction between the MTHFR 677C&gt;T genotype and S-cobalamin on tHcy levels was demonstrated in both genders.	thcy	83-87	methylenetetrahydrofolate reductase	Serinus canaria	39-44
24498831-2	2013	Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels.	thcy	298-302	methylenetetrahydrofolate reductase	Homo sapiens	82-122
24853127-4	2014	The aim of this study is to examine whether genetic variants in MTHFR gene are associated with the risk of ischemic stroke and fasting total serum homocysteine (tHcy) level.	thcy	161-165	methylenetetrahydrofolate reductase	Homo sapiens	64-69
24853127-8	2014	Besides, the MTHFR rs1801133 and rs9651118 were significantly associated with serum levels of tHcy in healthy controls (p&lt;0.0001 and p=0.02).	thcy	94-98	methylenetetrahydrofolate reductase	Homo sapiens	13-18
24853127-9	2014	These findings suggest that variants in the MTHFR gene may influence the risk of ischemic stroke and serum tHcy.	thcy	107-111	methylenetetrahydrofolate reductase	Homo sapiens	44-49
24712432-9	2014	CONCLUSIONS: Some athrogenic effects of leptin may be mediated by affecting tHcy and NO levels.	thcy	76-80	leptin	Homo sapiens	40-46
25165408-4	2014	The aim of this study is to examine whether polymorphisms in the MTHFR gene are associated with risk of type 2 diabetes mellitus (T2DM) and fasting total serum homocysteine (tHcy) levels.	thcy	174-178	methylenetetrahydrofolate reductase	Homo sapiens	65-70
25165408-8	2014	Besides, the MTHFR rs1801133 was significantly associated with serum levels of tHcy in healthy controls (P = 0.0002).	thcy	79-83	methylenetetrahydrofolate reductase	Homo sapiens	13-18
25165408-10	2014	These findings suggest that variants in the MTHFR gene may influence the risk of T2DM and tHcy levels.	thcy	90-94	methylenetetrahydrofolate reductase	Homo sapiens	44-49
24014284-3	2013	The methylene tetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism (rs1801133) is among the strongest genetic predictors of tHcy.	thcy	129-133	methylenetetrahydrofolate reductase	Ovis aries	4-40
24014284-3	2013	The methylene tetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism (rs1801133) is among the strongest genetic predictors of tHcy.	thcy	129-133	methylenetetrahydrofolate reductase	Ovis aries	42-47
24014284-11	2013	In SHEEP, the association between tHcy and MI was observed in MTHFR 677 C-homozygotes (OR=1.4, 95% CI 1.2 to 1.6, for a difference by 1 SD of log tHcy) and in heterozygotes (OR=1.3, 95% CI 1.1 to 1.6) but not in T-homozygotes, independent of smoking, physical activity and obesity.	thcy	34-38	methylenetetrahydrofolate reductase	Ovis aries	62-67
24014284-11	2013	In SHEEP, the association between tHcy and MI was observed in MTHFR 677 C-homozygotes (OR=1.4, 95% CI 1.2 to 1.6, for a difference by 1 SD of log tHcy) and in heterozygotes (OR=1.3, 95% CI 1.1 to 1.6) but not in T-homozygotes, independent of smoking, physical activity and obesity.	thcy	146-150	methylenetetrahydrofolate reductase	Ovis aries	62-67
24014284-13	2013	CONCLUSIONS: Two Swedish case-control studies showed that the association between elevated tHcy and CHD was confined to carriers of the MTHFR 677 C-allele, which could have implications for the efficiency of tHcy-lowering treatment.	thcy	91-95	methylenetetrahydrofolate reductase	Ovis aries	136-141
24014284-13	2013	CONCLUSIONS: Two Swedish case-control studies showed that the association between elevated tHcy and CHD was confined to carriers of the MTHFR 677 C-allele, which could have implications for the efficiency of tHcy-lowering treatment.	thcy	208-212	methylenetetrahydrofolate reductase	Ovis aries	136-141
24982225-3	2014	tHcy (mean+-SD) was 10.2+-3.4 muM and significantly correlated with age.	thcy	0-4	latexin	Homo sapiens	30-33
24472005-3	2014	Thus, polymorphisms of MTHFR could potentially contribute to the development of vitiligo by affecting MTHFR activity and tHcy levels.	thcy	121-125	methylenetetrahydrofolate reductase	Homo sapiens	23-28
24337902-1	2014	In hyperhomocysteinemic patients, after reaction with homocysteine-albumin mixed disulfides (HSS-ALB), mesna (MSH) forms the mixed disulfide with Hcy (HSSM) which can be removed by renal clearance, thus reducing the plasma concentration of total homocysteine (tHcy).	thcy	260-264	msh homeobox 2	Homo sapiens	110-113
24337902-5	2014	Since it was observed that the dimesna production could be detrimental for the in vivo optimization of HSSM formation, we assume that the best plasma tHcy lowering can be obtained at MSH doses producing the minimum dimesna concentration in each individual.	thcy	150-154	msh homeobox 2	Homo sapiens	183-186
24189943-4	2014	Cbs(-/-) mice fed the MRD had a 77% decrease in tHcy, 28% increase in weight, 130% increase in fat mass, 82% increase in Scd-1 expression, and 10.6% increase in bone density and entirely lacked the alopecia phenotype observed in age-matched Cbs(-/-) mice fed the RD.	thcy	48-52	cystathionine beta-synthase	Mus musculus	0-3
24183735-3	2013	The role of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene (MTHFR) on the increase of plasma tHcy in patients with epilepsy taking AEDs is still controversial.	thcy	121-125	methylenetetrahydrofolate reductase	Homo sapiens	46-81
24183735-3	2013	The role of C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase gene (MTHFR) on the increase of plasma tHcy in patients with epilepsy taking AEDs is still controversial.	thcy	121-125	methylenetetrahydrofolate reductase	Homo sapiens	88-93
24498831-2	2013	Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels.	thcy	298-302	methylenetetrahydrofolate reductase	Homo sapiens	124-129
24498831-6	2013	Moreover, as the multiple linear regression analysis indicated, smoking habit, folate levels and the MTHFR Val/Val genotype were the only major predictors of tHcy concentrations in the current investigation.	thcy	158-162	methylenetetrahydrofolate reductase	Homo sapiens	101-106
23643559-6	2013	The tHcy concentration was higher in MTHFR TT homozygote individuals than in wild-type CC individuals.	thcy	4-8	methylenetetrahydrofolate reductase	Homo sapiens	37-42
23697869-3	2013	We wanted to study if tHcy and its major determinants were correlated with Apo A1 levels in a large population without folate fortification.	thcy	22-26	apolipoprotein A1	Homo sapiens	75-81
23417011-7	2013	We suggest that T-DMRs participate in the regulation of expression of the FOLR1 and RFC1 genes, that the RFC1 80G &gt; A polymorphism exerts a gene-nutrition interaction on DNA methylation in the RFC1 gene, and that this interaction appears to be most prominent in NTD-affected births and in subjects with high tHcy concentrations.	thcy	311-315	folate receptor alpha	Homo sapiens	74-79
23417011-7	2013	We suggest that T-DMRs participate in the regulation of expression of the FOLR1 and RFC1 genes, that the RFC1 80G &gt; A polymorphism exerts a gene-nutrition interaction on DNA methylation in the RFC1 gene, and that this interaction appears to be most prominent in NTD-affected births and in subjects with high tHcy concentrations.	thcy	311-315	fuzzy planar cell polarity protein	Homo sapiens	265-268
23697869-10	2013	CONCLUSIONS: Analyzing over 1500 subjects we found an independent positive association between plasma folate (major dietary determinant of tHcy) and Apo A1 levels among those who later did not develop a first myocardial infarction.	thcy	139-143	apolipoprotein A1	Homo sapiens	149-155
23298782-7	2013	The present study confirmed that an inverse relationship exists between plasma tHcy and serum vitamin B12, from which it can be concluded that the usual dietary source of vitamin B12 is animal products and those who choose to omit or restrict these products are destined to become vitamin B12 deficient.	thcy	79-83	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	102-105