PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	pelargonidin	84-96	prostaglandin-endoperoxide synthase 1	Homo sapiens	113-118
34290971-16	2021	The protective effect of PG against Abeta may be due to its anti-apoptotic property.	pelargonidin	25-27	amyloid beta precursor protein	Rattus norvegicus	36-41
33552591-0	2021	Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway.	pelargonidin	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-108
33552591-0	2021	Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway.	pelargonidin	0-12	heme oxygenase 1	Rattus norvegicus	109-113
33552591-11	2021	Conclusions: Our data demonstrated that pelargonidin ameliorated neurological function deficits in MCAO rats, and its potential mechanism of action was associated with overexpression of the Nrf2/HO-1-signaling pathway.	pelargonidin	40-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	190-194
33552591-11	2021	Conclusions: Our data demonstrated that pelargonidin ameliorated neurological function deficits in MCAO rats, and its potential mechanism of action was associated with overexpression of the Nrf2/HO-1-signaling pathway.	pelargonidin	40-52	heme oxygenase 1	Rattus norvegicus	195-199
33039567-6	2021	Results of the mitotic-index observed from the PG-pre-treated-alloxan-administered (PG+ALX) mice group revealed a significant reduction in chromosomal-anomaly, DNA-damage, and an upregulation of the p53 and PARP protein expression when compared to the ALX-treated mice group.	pelargonidin	47-49	transformation related protein 53, pseudogene	Mus musculus	199-202
33039567-6	2021	Results of the mitotic-index observed from the PG-pre-treated-alloxan-administered (PG+ALX) mice group revealed a significant reduction in chromosomal-anomaly, DNA-damage, and an upregulation of the p53 and PARP protein expression when compared to the ALX-treated mice group.	pelargonidin	47-49	poly (ADP-ribose) polymerase family, member 1	Mus musculus	207-211
33872570-6	2021	The results of these studies demonstrated that pelargonidin activates the Aryl hydrocarbon Receptor (AHR) in vitro and reverses intestinal inflammation caused by chronic exposure to high fat diet or to the intestinal braking-barrier agent TNBS in a AhR-dependent manner.	pelargonidin	47-59	aryl hydrocarbon receptor	Homo sapiens	74-99
33872570-6	2021	The results of these studies demonstrated that pelargonidin activates the Aryl hydrocarbon Receptor (AHR) in vitro and reverses intestinal inflammation caused by chronic exposure to high fat diet or to the intestinal braking-barrier agent TNBS in a AhR-dependent manner.	pelargonidin	47-59	aryl hydrocarbon receptor	Homo sapiens	101-104
33872570-6	2021	The results of these studies demonstrated that pelargonidin activates the Aryl hydrocarbon Receptor (AHR) in vitro and reverses intestinal inflammation caused by chronic exposure to high fat diet or to the intestinal braking-barrier agent TNBS in a AhR-dependent manner.	pelargonidin	47-59	aryl hydrocarbon receptor	Homo sapiens	249-252
33872570-9	2021	Molecular docking studies suggested that pelargonidin binds a fatty acid binding pocket on the receptor binding domain of SARS-CoV-2 Spike protein.	pelargonidin	41-53	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	133-138
33872570-10	2021	In vitro studies demonstrated that pelargonidin significantly reduces the binding of SARS-CoV-2 Spike protein to ACE2 and reduces the SARS-CoV-2 replication in a concentration-dependent manner.	pelargonidin	35-47	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	96-101
33872570-10	2021	In vitro studies demonstrated that pelargonidin significantly reduces the binding of SARS-CoV-2 Spike protein to ACE2 and reduces the SARS-CoV-2 replication in a concentration-dependent manner.	pelargonidin	35-47	angiotensin converting enzyme 2	Homo sapiens	113-117
32648018-0	2020	Reply to: Pelargonidin and its glycosides as dietary chemopreventives attenuating inflammatory bowel disease symptoms through the aryl hydrocarbon receptor.	pelargonidin	10-22	aryl hydrocarbon receptor	Homo sapiens	130-155
32648020-0	2020	Pelargonidin and its glycosides as dietary chemopreventives attenuating inflammatory bowel disease symptoms through the aryl hydrocarbon receptor.	pelargonidin	0-12	aryl hydrocarbon receptor	Homo sapiens	120-145
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	pelargonidin	84-96	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	pelargonidin	98-100	prostaglandin-endoperoxide synthase 1	Homo sapiens	113-118
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	pelargonidin	98-100	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	120-125
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	pelargonidin	98-100	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	pelargonidin	98-100	tumor necrosis factor	Homo sapiens	175-178
32854331-10	2020	We retrieved the binding affinity of each ligand-target, and found that PG and COX-1 showed the strongest binding affinity among four binding results using a molecular docking method.	pelargonidin	72-74	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	79-84
32280641-3	2019	In this study, the possible protective effects of pelargonidin (a natural flavonoid) against amyloid beta (Abeta)-induced behavioral deficits was investigated in rats.	pelargonidin	50-62	amyloid beta precursor protein	Rattus norvegicus	107-112
32315651-0	2020	Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-gamma signaling pathway.	pelargonidin	0-12	peroxisome proliferator activated receptor gamma	Mus musculus	75-85
32315651-8	2020	Besides, the result of Luciferase Reporter Assay indicated that pelargonidin inhibited PPAR-gamma transcription activity.	pelargonidin	64-76	peroxisome proliferator activated receptor gamma	Mus musculus	87-97
32315651-9	2020	These results indicated that pelargonidin exerts anti-adipogenic activity in 3T3-L1 cells through inhibition of PPAR-gamma signaling pathway, and pelargonidin could be used as a potential anti-obesity agent.	pelargonidin	29-41	peroxisome proliferator activated receptor gamma	Mus musculus	112-122
32684465-7	2020	Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7).	pelargonidin	101-113	cytokine like 1	Homo sapiens	143-146
32684465-7	2020	Specifically, various stronger positive correlations were noted for anthocyanin composition and UFA (pelargonidin and petunidin with C14:1n-5, C17:1n-7, C18:2n-6, C20:2n-6, C20:3n-3, and C20:4n-6; and cyanidin and total anthocyanins with C14:1n-5, C16:1n-7, C17:1n-7).	pelargonidin	101-113	Bardet-Biedl syndrome 9	Homo sapiens	153-156
32280641-10	2019	Conclusion: The results of this study suggest that pelargonidin can improve Abeta-induced behavioral changes in rats.	pelargonidin	51-63	amyloid beta precursor protein	Rattus norvegicus	76-81
31181187-0	2019	Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.	pelargonidin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
31181187-7	2019	Importantly, pelargonidin decreased the DNA methylation in the Nrf2 promoter region of JB6 P+ cells and increased Nrf2 downstream target genes expression, such as NAD(P)H/quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), involved in cellular protection.	pelargonidin	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
31181187-7	2019	Importantly, pelargonidin decreased the DNA methylation in the Nrf2 promoter region of JB6 P+ cells and increased Nrf2 downstream target genes expression, such as NAD(P)H/quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), involved in cellular protection.	pelargonidin	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
31181187-7	2019	Importantly, pelargonidin decreased the DNA methylation in the Nrf2 promoter region of JB6 P+ cells and increased Nrf2 downstream target genes expression, such as NAD(P)H/quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), involved in cellular protection.	pelargonidin	13-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	163-195
31181187-7	2019	Importantly, pelargonidin decreased the DNA methylation in the Nrf2 promoter region of JB6 P+ cells and increased Nrf2 downstream target genes expression, such as NAD(P)H/quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), involved in cellular protection.	pelargonidin	13-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	197-201
31181187-7	2019	Importantly, pelargonidin decreased the DNA methylation in the Nrf2 promoter region of JB6 P+ cells and increased Nrf2 downstream target genes expression, such as NAD(P)H/quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1), involved in cellular protection.	pelargonidin	13-25	heme oxygenase 1	Homo sapiens	207-223
30003744-10	2018	The anticancer effects of pelargonidin were due to induction of autophagy as evidenced from the expression of LC3-I, LC-3II and Beclin-1.	pelargonidin	26-38	beclin 1	Homo sapiens	128-136
31394746-0	2019	The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.	pelargonidin	79-92	aryl-hydrocarbon receptor	Mus musculus	4-29
31394746-0	2019	The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.	pelargonidin	79-92	aryl-hydrocarbon receptor	Mus musculus	31-34
31394746-10	2019	Mt-P is a synthetic pelargonidin endowed with robust AhR agonist activity that exerts beneficial effects in murine models of inflammation and metabolic dysfunction.	pelargonidin	20-32	aryl-hydrocarbon receptor	Mus musculus	53-56
29230174-0	2017	Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells.	pelargonidin	0-12	kelch like ECH associated protein 1	Homo sapiens	23-28
29230174-0	2017	Pelargonidin Modulates Keap1/Nrf2 Pathway Gene Expression and Ameliorates Citrinin-Induced Oxidative Stress in HepG2 Cells.	pelargonidin	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
29230174-10	2017	These data demonstrate the protective effect of PC against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.	pelargonidin	48-50	kelch like ECH associated protein 1	Homo sapiens	173-178
29230174-10	2017	These data demonstrate the protective effect of PC against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.	pelargonidin	48-50	NFE2 like bZIP transcription factor 2	Homo sapiens	179-183
26842771-7	2016	Strawberry intake reduced the insulin demand to manage postmeal glucose in obese individuals with IR, which was related to plasma anthocyanin/pelargonidin concentrations.	pelargonidin	142-154	insulin	Homo sapiens	30-37
28950208-4	2017	Flowcytometry and immunoblot analysis confirmed that pelargonidin specifically inhibits the activation of CDK1 and blocks the G2-M transition of the cell cycle.	pelargonidin	53-65	cyclin dependent kinase 1	Homo sapiens	106-110
28950208-6	2017	Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin"s action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation.	pelargonidin	82-94	cyclin dependent kinase 1	Homo sapiens	129-133
28950208-6	2017	Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin"s action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation.	pelargonidin	82-94	cyclin dependent kinase 4	Homo sapiens	135-139
28950208-6	2017	Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin"s action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation.	pelargonidin	82-94	cyclin dependent kinase 6	Homo sapiens	145-149
28950208-6	2017	Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin"s action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation.	pelargonidin	82-94	DNA methyltransferase 1	Homo sapiens	193-198
28950208-6	2017	Hence, the aim of the present study was to investigate the molecular mechanism of pelargonidin"s action on cell cycle regulators CDK1, CDK4, and CDK6 as well as the substrate-binding domain of DNMT1 and DNMT3A, which regulate the epigenetic signals related to DNA methylation.	pelargonidin	82-94	DNA methyltransferase 3 alpha	Homo sapiens	203-209
28950208-7	2017	The results of docking analysis, binding free energy calculation, and molecular dynamics simulation correlated with the experimental results, and pelargonidin showed a specific interaction with CDK1.	pelargonidin	146-158	cyclin dependent kinase 1	Homo sapiens	194-198
28950208-8	2017	In this context, pelargonidin may also inhibit the recognition of DNA and catalytic binding by DNMT1 and DNMT3A.	pelargonidin	17-29	DNA methyltransferase 1	Homo sapiens	95-100
28950208-8	2017	In this context, pelargonidin may also inhibit the recognition of DNA and catalytic binding by DNMT1 and DNMT3A.	pelargonidin	17-29	DNA methyltransferase 3 alpha	Homo sapiens	105-111
27778275-0	2016	Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo.	pelargonidin	23-35	high mobility group box 1	Mus musculus	39-44
28060523-0	2017	Anti-inflammatory effects of pelargonidin on TGFBIp-induced responses.	pelargonidin	29-41	transforming growth factor beta induced	Homo sapiens	45-51
27309265-2	2016	Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects.	pelargonidin	0-12	estrogen receptor 1	Rattus norvegicus	53-70
26762345-5	2016	Pelargonidin, but not pelargonidin-3-glucoside, prolonged the aPTT and PT, and inhibited the activity and production of thrombin and FXa in human umbilical vein endothelial cells.	pelargonidin	0-12	coagulation factor II, thrombin	Homo sapiens	120-128
26762345-5	2016	Pelargonidin, but not pelargonidin-3-glucoside, prolonged the aPTT and PT, and inhibited the activity and production of thrombin and FXa in human umbilical vein endothelial cells.	pelargonidin	0-12	coagulation factor X	Homo sapiens	133-136
26762345-6	2016	Furthermore, pelargonidin inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation and elicited anticoagulant effects in mice.	pelargonidin	13-25	coagulation factor II	Mus musculus	36-44
26762345-7	2016	In addition, pelargonidin significantly reduced PAI-1 to t-PA ratio.	pelargonidin	13-25	serpin family E member 1	Homo sapiens	48-53
26762345-7	2016	In addition, pelargonidin significantly reduced PAI-1 to t-PA ratio.	pelargonidin	13-25	plasminogen activator, tissue type	Homo sapiens	57-61
27222063-0	2016	Suppressive Effects of Pelargonidin on Endothelial Protein C Receptor Shedding via the Inhibition of TACE Activity and MAP Kinases.	pelargonidin	23-35	protein C receptor	Homo sapiens	39-69
27222063-0	2016	Suppressive Effects of Pelargonidin on Endothelial Protein C Receptor Shedding via the Inhibition of TACE Activity and MAP Kinases.	pelargonidin	23-35	ADAM metallopeptidase domain 17	Homo sapiens	101-105
27222063-4	2016	However, little is known about the effects of pelargonidin on EPCR shedding.	pelargonidin	46-58	protein C receptor	Homo sapiens	62-66
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	tumor necrosis factor	Homo sapiens	70-73
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	interleukin 1 beta	Homo sapiens	96-104
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	protein C receptor	Homo sapiens	123-127
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	mitogen-activated protein kinase 1	Homo sapiens	224-227
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	mitogen-activated protein kinase 8	Homo sapiens	229-241
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	mitogen-activated protein kinase 8	Homo sapiens	243-246
27222063-6	2016	Data demonstrate that pelargonidin induced potent inhibition of PMA-, TNF-[Formula: see text]-, IL-1beta-, and CLP-induced EPCR shedding by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) such as p38, janus kinase (JNK), and extracellular signal-regulated kinase (ERK) 1/2.	pelargonidin	22-34	mitogen-activated protein kinase 3	Homo sapiens	253-300
27222063-7	2016	Pelargonidin also inhibited the expression and activity of PMA-induced TACE in endothelial cells.	pelargonidin	0-12	ADAM metallopeptidase domain 17	Homo sapiens	71-75
27222063-8	2016	These results demonstrate the potential of pelargonidin as an anti-EPCR shedding reagent against PMA- and CLP-mediated EPCR shedding.	pelargonidin	43-55	protein C receptor	Homo sapiens	67-71
27222063-8	2016	These results demonstrate the potential of pelargonidin as an anti-EPCR shedding reagent against PMA- and CLP-mediated EPCR shedding.	pelargonidin	43-55	protein C receptor	Homo sapiens	119-123
24582770-0	2014	Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase.	pelargonidin	0-12	protein tyrosine kinase 2	Homo sapiens	118-139
24582770-5	2014	Immunoblot analysis revealed that pelargonidin inhibited PDGF-BB-induced phosphorylation of focal adhesion kinase (FAK) as well as F-actin reduction, whereas Src, mitogen-activated protein kinases (MAPKs) and Akt phosphorylation status were not altered.	pelargonidin	34-46	protein tyrosine kinase 2	Homo sapiens	92-113
24582770-5	2014	Immunoblot analysis revealed that pelargonidin inhibited PDGF-BB-induced phosphorylation of focal adhesion kinase (FAK) as well as F-actin reduction, whereas Src, mitogen-activated protein kinases (MAPKs) and Akt phosphorylation status were not altered.	pelargonidin	34-46	protein tyrosine kinase 2	Homo sapiens	115-118
24582770-6	2014	We also observed that the anti-proliferative and migratory effects of both pelargonidin and P3G corresponded with the extent of FAK inhibition.	pelargonidin	75-87	protein tyrosine kinase 2	Homo sapiens	128-131
24582770-7	2014	Both in vitro and ex vivo pull-down assays revealed that pelargonidin binds directly with FAK in an adenosine triphosphate-competitive manner, suggesting that FAK could be a molecular target of pelargonidin.	pelargonidin	57-69	protein tyrosine kinase 2	Homo sapiens	90-93
24582770-7	2014	Both in vitro and ex vivo pull-down assays revealed that pelargonidin binds directly with FAK in an adenosine triphosphate-competitive manner, suggesting that FAK could be a molecular target of pelargonidin.	pelargonidin	57-69	protein tyrosine kinase 2	Homo sapiens	159-162
24582770-7	2014	Both in vitro and ex vivo pull-down assays revealed that pelargonidin binds directly with FAK in an adenosine triphosphate-competitive manner, suggesting that FAK could be a molecular target of pelargonidin.	pelargonidin	194-206	protein tyrosine kinase 2	Homo sapiens	90-93
24582770-7	2014	Both in vitro and ex vivo pull-down assays revealed that pelargonidin binds directly with FAK in an adenosine triphosphate-competitive manner, suggesting that FAK could be a molecular target of pelargonidin.	pelargonidin	194-206	protein tyrosine kinase 2	Homo sapiens	159-162
24582770-9	2014	Taken together, our results suggest that pelargonidin exhibits potential preventive effects toward atherosclerosis through the attenuation of HASMC proliferation and migration, as well as aortic sprouting via the direct inhibition of FAK activity.	pelargonidin	41-53	protein tyrosine kinase 2	Homo sapiens	234-237
23419638-7	2013	Overall, although most anthocyanidins had no effects on AhR-CYP1A1 signaling, pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and pelargonidin and delphinidin inhibit the CYP1A1 catalytic activity.	pelargonidin	163-175	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	204-210
23320385-3	2013	The aim of this study was to evaluate inhibitory effect of four anthocyanidins (delphinidin, cyanidin, malvidin and pelargonidin) on three families of important drug-metabolizing enzymes: carbonyl reductases (CBRs), glutathione S-transferases (GSTs) and UDP-glucuronosyltransferases (UGT).	pelargonidin	116-128	beta-1,3-glucuronyltransferase 2	Homo sapiens	254-282
23320385-3	2013	The aim of this study was to evaluate inhibitory effect of four anthocyanidins (delphinidin, cyanidin, malvidin and pelargonidin) on three families of important drug-metabolizing enzymes: carbonyl reductases (CBRs), glutathione S-transferases (GSTs) and UDP-glucuronosyltransferases (UGT).	pelargonidin	116-128	beta-1,3-glucuronyltransferase 2	Homo sapiens	284-287
23419638-0	2013	Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.	pelargonidin	0-12	aryl hydrocarbon receptor	Homo sapiens	27-30
23419638-0	2013	Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.	pelargonidin	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
22218934-7	2012	Delphinidin-3-glucoside, pelargonidin-3-glucoside, and gallic acid showed affinity for ERbeta and pelargonidin and peonidin-3-glucosides for ERalpha.	pelargonidin	25-37	estrogen receptor 2	Homo sapiens	87-93
23419638-1	2013	We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells.	pelargonidin	97-109	aryl hydrocarbon receptor	Homo sapiens	118-143
23419638-1	2013	We examined the effects of anthocyanidins (cyanidin, delphinidin, malvidin, peonidin, petunidin, pelargonidin) on the aryl hydrocarbon receptor (AhR)-CYP1A1 signaling pathway in human hepatocytes, hepatic HepG2 and intestinal LS174T cancer cells.	pelargonidin	97-109	aryl hydrocarbon receptor	Homo sapiens	145-148
23419638-2	2013	AhR-dependent reporter gene expression in transfected HepG2 cells was increased by pelargonidin in a concentration-dependent manner at 24h.	pelargonidin	83-95	aryl hydrocarbon receptor	Homo sapiens	0-3
23419638-5	2013	Ligand binding analysis demonstrated that pelargonidin was a weak ligand of AhR.	pelargonidin	42-54	aryl hydrocarbon receptor	Homo sapiens	76-79
23419638-6	2013	Enzyme kinetic analyses using human liver microsomes revealed inhibition of CYP1A1 activity by delphinidin (IC50 78 muM) and pelargonidin (IC50 33 muM).	pelargonidin	125-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	76-82
23419638-6	2013	Enzyme kinetic analyses using human liver microsomes revealed inhibition of CYP1A1 activity by delphinidin (IC50 78 muM) and pelargonidin (IC50 33 muM).	pelargonidin	125-137	latexin	Homo sapiens	147-150
23419638-7	2013	Overall, although most anthocyanidins had no effects on AhR-CYP1A1 signaling, pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and pelargonidin and delphinidin inhibit the CYP1A1 catalytic activity.	pelargonidin	78-90	aryl hydrocarbon receptor	Homo sapiens	120-123
23419638-7	2013	Overall, although most anthocyanidins had no effects on AhR-CYP1A1 signaling, pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and pelargonidin and delphinidin inhibit the CYP1A1 catalytic activity.	pelargonidin	78-90	aryl hydrocarbon receptor	Homo sapiens	120-123
22218934-7	2012	Delphinidin-3-glucoside, pelargonidin-3-glucoside, and gallic acid showed affinity for ERbeta and pelargonidin and peonidin-3-glucosides for ERalpha.	pelargonidin	25-37	estrogen receptor 1	Homo sapiens	141-148
21385724-1	2011	In maize, mutations in the pr1 locus lead to the accumulation of pelargonidin (red) rather than cyanidin (purple) pigments in aleurone cells where the anthocyanin biosynthetic pathway is active.	pelargonidin	65-77	pathogenesis related protein 4	Zea mays	27-30
11699869-0	2001	Effects of pelargonidine and a benzocaine analogue p-diethylaminoethyl benzoate on mitochondrial K(ATP) channel.	pelargonidin	11-24	ATPase phospholipid transporting 8A2	Homo sapiens	83-103
15588587-0	2004	Purification and cloning of a Chinese red radish peroxidase that metabolise pelargonidin and forms a gene family in Brassicaceae.	pelargonidin	76-88	peroxidase	Arabidopsis thaliana	49-59
11553733-5	2001	The expression of the maize A1 gene in the flavonoid 3" hydroxylase Arabidopsis tt7 mutant resulted in an increased accumulation of pelargonidin.	pelargonidin	132-144	Cytochrome P450 superfamily protein	Arabidopsis thaliana	80-83
11699869-4	2001	Pelargonidine extracted from Pelargonium flowers reduced the spontaneous activity of K(ATP) channels and attenuated DEB-induced channel activation.	pelargonidin	0-13	ATPase phospholipid transporting 8A2	Homo sapiens	87-90
20801663-6	2010	Furthermore, we determined a pharmacophore for delphinidin binding to the human GLO I by computational simulation analyses of the binding modes of delphinidin, cyanidin and pelargonidin to the enzyme hot spot.	pelargonidin	173-185	glyoxalase I	Homo sapiens	80-85
13679981-1	2003	We have recently identified an allele of dihydroflavonol 4-reductase ( dfr) that cosegregates with the ability of potato ( Solanum tuberosum L) to produce red pelargonidin-based anthocyanin pigments.	pelargonidin	159-171	dihydroflavonol 4-reductase	Solanum tuberosum	41-68
13679981-1	2003	We have recently identified an allele of dihydroflavonol 4-reductase ( dfr) that cosegregates with the ability of potato ( Solanum tuberosum L) to produce red pelargonidin-based anthocyanin pigments.	pelargonidin	159-171	dihydroflavonol 4-reductase	Solanum tuberosum	71-74
12590123-3	2003	Overexpression of a DNA encoding dihydroflavonol 4-reductase (DFR) in sense orientation resulted in an increase in tuber anthocyanins, a 4-fold increase in petunidin and pelargonidin derivatives.	pelargonidin	170-182	dihydroflavonol 4-reductase	Solanum tuberosum	33-60
12590123-3	2003	Overexpression of a DNA encoding dihydroflavonol 4-reductase (DFR) in sense orientation resulted in an increase in tuber anthocyanins, a 4-fold increase in petunidin and pelargonidin derivatives.	pelargonidin	170-182	dihydroflavonol 4-reductase	Solanum tuberosum	62-65