PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 27502608-6 2016 Mechanistically, GDF11 activates the TGF-beta/Smad2/3, AMPK/endothelial nitricoxide synthase (eNOS) while suppresses JNK and NF-kappaB pathways. gdf11 17-22 transforming growth factor, beta 1 Mus musculus 37-45 27502608-6 2016 Mechanistically, GDF11 activates the TGF-beta/Smad2/3, AMPK/endothelial nitricoxide synthase (eNOS) while suppresses JNK and NF-kappaB pathways. gdf11 17-22 SMAD family member 2 Mus musculus 46-53 27502608-6 2016 Mechanistically, GDF11 activates the TGF-beta/Smad2/3, AMPK/endothelial nitricoxide synthase (eNOS) while suppresses JNK and NF-kappaB pathways. gdf11 17-22 nitric oxide synthase 3, endothelial cell Mus musculus 60-92 27502608-6 2016 Mechanistically, GDF11 activates the TGF-beta/Smad2/3, AMPK/endothelial nitricoxide synthase (eNOS) while suppresses JNK and NF-kappaB pathways. gdf11 17-22 mitogen-activated protein kinase 8 Mus musculus 117-120 26489925-7 2016 GDF11 administration in mice rapidly activated SMAD2 and SMAD3 signaling in myocardium in vivo and decreased cardiac mass in both young (2-month-old) and old (22-month-old) mice in a dose-dependent manner after only 9 days. gdf11 0-5 SMAD family member 2 Mus musculus 47-52 26489925-7 2016 GDF11 administration in mice rapidly activated SMAD2 and SMAD3 signaling in myocardium in vivo and decreased cardiac mass in both young (2-month-old) and old (22-month-old) mice in a dose-dependent manner after only 9 days. gdf11 0-5 SMAD family member 3 Mus musculus 57-62 34676394-0 2022 DA-Raf and the MEK inhibitor trametinib reverse skeletal myocyte differentiation inhibition or muscle atrophy caused by myostatin and GDF11 through the non-Smad Ras-ERK pathway. gdf11 134-139 midkine Mus musculus 15-18 26226340-8 2015 A synthetic peptide corresponding to the inhibitory core (p29) ameliorates impaired myoblast differentiation induced by myostatin and GDF11, but not activin or TGF-beta1. gdf11 134-139 SYF2 homolog, RNA splicing factor (S. cerevisiae) Mus musculus 58-61 11203700-10 2001 Analysis of molecular markers of skeletal patterning revealed that GDF11 induced ectopic expression of Hoxd-11 and Hoxd-13, but not of Hoxa-11, Hoxa-13, or the Msx genes. gdf11 69-74 homeobox D11 Gallus gallus 105-112 11203700-10 2001 Analysis of molecular markers of skeletal patterning revealed that GDF11 induced ectopic expression of Hoxd-11 and Hoxd-13, but not of Hoxa-11, Hoxa-13, or the Msx genes. gdf11 69-74 homeobox D13 Gallus gallus 117-124 34676394-0 2022 DA-Raf and the MEK inhibitor trametinib reverse skeletal myocyte differentiation inhibition or muscle atrophy caused by myostatin and GDF11 through the non-Smad Ras-ERK pathway. gdf11 134-139 mitogen-activated protein kinase 1 Mus musculus 165-168 35461108-0 2022 GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFbetaR1/SMAD-2 pathway. gdf11 0-5 SMAD family member 2 Rattus norvegicus 124-130 31418854-0 2020 GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression. gdf11 0-5 hepcidin antimicrobial peptide Mus musculus 29-37 33684566-0 2021 GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling. gdf11 0-5 transforming growth factor beta receptor 1 Homo sapiens 73-77 33684566-7 2021 GDF11 treatment rapidly triggered ALK5-dependent SMAD2/3 nuclear translocation and elevated lipid droplets in HCC cells, but not in primary hepatocytes. gdf11 0-5 transforming growth factor beta receptor 1 Homo sapiens 34-38 33684566-7 2021 GDF11 treatment rapidly triggered ALK5-dependent SMAD2/3 nuclear translocation and elevated lipid droplets in HCC cells, but not in primary hepatocytes. gdf11 0-5 SMAD family member 2 Homo sapiens 49-56 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 yes-associated protein 1 Mus musculus 48-51 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 SMAD family member 2 Mus musculus 52-59 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 cellular communication network factor 2 Mus musculus 60-64 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 yes-associated protein 1 Mus musculus 155-158 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 yes-associated protein 1 Mus musculus 155-158 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 SMAD family member 2 Mus musculus 180-187 32560821-4 2020 Further study revealed that GDF11 activated the YAP-Smad2/3-CTGF fibrotic signaling pathway by reversing HG-induced upregulation of phosphorylated form of YAP (p-YAP), increases p-Smad2/3 levels, and restoring HG-induced repression of CTGF expression by GDF11. gdf11 28-33 cellular communication network factor 2 Mus musculus 235-239 33728018-7 2021 Our results showed that PPARalpha inhibited vascular endothelial cell senescence and apoptosis and promoted vascular endothelial cell proliferation and angiogenesis by increasing GDF11 production. gdf11 179-184 peroxisome proliferator activated receptor alpha Mus musculus 24-33 33077875-7 2020 Finally, we discuss the potential use of recombinant GDF11 as a therapeutic option for a wide range of medical conditions and the possible adverse effects of GDF11 inhibition mediated by MSTN inhibitors. gdf11 158-163 myostatin Mus musculus 187-191 31418854-0 2020 GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression. gdf11 0-5 hepcidin antimicrobial peptide Mus musculus 39-43 31418854-0 2020 GDF11 contributes to hepatic hepcidin (HAMP) inhibition through SMURF1-mediated BMP-SMAD signalling suppression. gdf11 0-5 SMAD specific E3 ubiquitin protein ligase 1 Mus musculus 64-70 31418854-8 2020 Exogeneous GDF11 administration results in HAMP suppression in vivo and in vitro. gdf11 11-16 hepcidin antimicrobial peptide Mus musculus 43-47 28450417-5 2017 Mechanistically, the GDF11-mediated protective effects could be attributed to the activation of transforming growth factor-beta/Smad2 and phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT-FoxO1 signaling. gdf11 21-26 SMAD family member 2 Mus musculus 128-133 29161592-3 2017 GDF11 promotes an epithelial, anti-invasive phenotype in 3D triple-negative cultures and intraductal xenografts by sustaining expression of E-cadherin and inhibitor of differentiation 2 (ID2). gdf11 0-5 cadherin 1 Homo sapiens 140-150 29161592-3 2017 GDF11 promotes an epithelial, anti-invasive phenotype in 3D triple-negative cultures and intraductal xenografts by sustaining expression of E-cadherin and inhibitor of differentiation 2 (ID2). gdf11 0-5 inhibitor of DNA binding 2 Homo sapiens 155-185 29161592-3 2017 GDF11 promotes an epithelial, anti-invasive phenotype in 3D triple-negative cultures and intraductal xenografts by sustaining expression of E-cadherin and inhibitor of differentiation 2 (ID2). gdf11 0-5 inhibitor of DNA binding 2 Homo sapiens 187-190 30900023-8 2019 Notably, pretreatment with the activin-binding protein, follistatin (FST), inhibited the cardioprotective effects of GDF11 by blocking its activation of Smad2/3 signaling and its inactivation of detrimental TGF-beta signaling. gdf11 117-122 follistatin Rattus norvegicus 56-67 30900023-8 2019 Notably, pretreatment with the activin-binding protein, follistatin (FST), inhibited the cardioprotective effects of GDF11 by blocking its activation of Smad2/3 signaling and its inactivation of detrimental TGF-beta signaling. gdf11 117-122 SMAD family member 2 Rattus norvegicus 153-160 30900023-8 2019 Notably, pretreatment with the activin-binding protein, follistatin (FST), inhibited the cardioprotective effects of GDF11 by blocking its activation of Smad2/3 signaling and its inactivation of detrimental TGF-beta signaling. gdf11 117-122 transforming growth factor, beta 1 Rattus norvegicus 207-215 30571461-8 2018 Treatment with GDF11 increased plasma concentrations of GDF11 and p-SMAD2 in the heart. gdf11 15-20 SMAD family member 2 Mus musculus 68-73 29731246-10 2018 GDF11 induced proliferation and activation of NRK49f renal fibroblasts and also promoted epithelial-to-mesenchymal transition of IMCD-3 tubular epithelial cells in a SMAD3-dependent manner. gdf11 0-5 SMAD family member 3 Mus musculus 166-171 29432795-10 2018 Our results strongly suggest that GDF11 improves neurofunctional recovery from cerebral I/R injury and that this effect is mediated partly through its proangiogenic effect in the peri-infarct cerebral cortex, which is associated with ALK5. gdf11 34-39 transforming growth factor, beta receptor 1 Rattus norvegicus 234-238 28450417-5 2017 Mechanistically, the GDF11-mediated protective effects could be attributed to the activation of transforming growth factor-beta/Smad2 and phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT-FoxO1 signaling. gdf11 21-26 thymoma viral proto-oncogene 1 Mus musculus 185-188 28450417-5 2017 Mechanistically, the GDF11-mediated protective effects could be attributed to the activation of transforming growth factor-beta/Smad2 and phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT-FoxO1 signaling. gdf11 21-26 forkhead box O1 Mus musculus 189-194