PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32422636-9 2020 In correlation analysis, there were inverse correlation between mean cTp-e interval and CD4 count and Tp-e/QTc ratios and CD4 count (r = - 0.407, p <0.001, r = - 0.416, p <0.001, respectively). qtc 107-110 CD4 molecule Homo sapiens 88-91 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 interleukin 6 Homo sapiens 68-81 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 interleukin 6 Homo sapiens 83-87 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 intercellular adhesion molecule 1 Homo sapiens 90-123 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 intercellular adhesion molecule 1 Homo sapiens 125-131 30366934-10 2019 Among the subgroup with inflammatory biomarker measurements, higher interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1) and B-cell activating factor levels were independently associated with longer QTc and their inclusion partially attenuated the HIV effect. qtc 211-214 TNF superfamily member 13b Homo sapiens 137-161 30047011-8 2019 Co-injection of WT KCNH2 cRNA shortened the QTc interval, however, that of the E637K did not. qtc 44-47 potassium voltage-gated channel, subfamily H (eag-related), member 2a Danio rerio 19-24 29887480-7 2018 The mean +- SE BAp was -1.4 +- 1.8 ms for QTc in all subjects, 8.3 +- 2.3 and -7.2 +- 2.5 ms respectively in controls and LQTS. qtc 42-45 prohibitin 2 Homo sapiens 15-18 30173151-2 2018 We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ). qtc 104-107 interleukin 6 Homo sapiens 133-146 30173151-7 2018 Baseline QTc was significantly and independently higher among those with anticyclic citrullinated peptide antibodies seropositivity, higher swollen joint counts, and higher levels of C-reactive protein (CRP) and matrix metalloproteinase 3. qtc 9-12 C-reactive protein Homo sapiens 203-206 30173151-8 2018 Each log unit decrease in CRP with treatment was associated with an average reduction in QTc of 2.9 ms (p = 0.002) after adjusting for age and baseline QTc. qtc 89-92 C-reactive protein Homo sapiens 26-29 30173151-8 2018 Each log unit decrease in CRP with treatment was associated with an average reduction in QTc of 2.9 ms (p = 0.002) after adjusting for age and baseline QTc. qtc 152-155 C-reactive protein Homo sapiens 26-29 30519263-8 2018 We found that QTC, especially when administered in high-dosages, had a significant inhibitory effect on bladder weight gain and overexpression of NGF, bFGF, and TGF-beta1 in rats with BPH. qtc 14-17 nerve growth factor Rattus norvegicus 146-149 30519263-8 2018 We found that QTC, especially when administered in high-dosages, had a significant inhibitory effect on bladder weight gain and overexpression of NGF, bFGF, and TGF-beta1 in rats with BPH. qtc 14-17 fibroblast growth factor 2 Rattus norvegicus 151-155 30519263-8 2018 We found that QTC, especially when administered in high-dosages, had a significant inhibitory effect on bladder weight gain and overexpression of NGF, bFGF, and TGF-beta1 in rats with BPH. qtc 14-17 transforming growth factor, beta 1 Rattus norvegicus 161-170 30519263-9 2018 In addition, QTC downregulated and upregulated protein and mRNA expression of Bcl-2 and Bax in the bladder after prostatic obstruction, respectively. qtc 13-16 BCL2, apoptosis regulator Rattus norvegicus 78-83 30519263-9 2018 In addition, QTC downregulated and upregulated protein and mRNA expression of Bcl-2 and Bax in the bladder after prostatic obstruction, respectively. qtc 13-16 BCL2 associated X, apoptosis regulator Rattus norvegicus 88-91 30519263-10 2018 Furthermore, QTC balanced the Bcl-2/Bax ratio. qtc 13-16 BCL2, apoptosis regulator Rattus norvegicus 30-35 30519263-10 2018 Furthermore, QTC balanced the Bcl-2/Bax ratio. qtc 13-16 BCL2 associated X, apoptosis regulator Rattus norvegicus 36-39 29622001-8 2018 LQT1 patients carrying the KCNQ1 D317N mutation were at higher risk (HR = 3.0-3.9, p < 0.001-0.03) compared to G589D, c.1129-2A > G and other KCNQ1 mutation carriers after adjusting for gender, QTc duration, and cardiac events before age 18. qtc 200-203 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-4 29429138-8 2018 Mixed general models showed a significant overall influence of SCN5A (H558R) on QTc duration but no significant interaction with antipsychotic treatment. qtc 80-83 sodium voltage-gated channel alpha subunit 5 Homo sapiens 63-68 29650123-8 2018 Intergenotype comparison showed that the risk for patients with LQT2 and LQT3 increased by 130% and 157% at any QTc duration versus patients with LQT1. qtc 112-115 potassium voltage-gated channel subfamily H member 2 Homo sapiens 64-68 29650123-8 2018 Intergenotype comparison showed that the risk for patients with LQT2 and LQT3 increased by 130% and 157% at any QTc duration versus patients with LQT1. qtc 112-115 sodium voltage-gated channel alpha subunit 5 Homo sapiens 73-77 29622001-8 2018 LQT1 patients carrying the KCNQ1 D317N mutation were at higher risk (HR = 3.0-3.9, p < 0.001-0.03) compared to G589D, c.1129-2A > G and other KCNQ1 mutation carriers after adjusting for gender, QTc duration, and cardiac events before age 18. qtc 200-203 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 27-32 28749187-1 2017 AIM: To investigate whether the differential methylation of KCNQ1OT1 was associated with the risk of symptomatic long QTc. qtc 118-121 KCNQ1 opposite strand/antisense transcript 1 Homo sapiens 60-68 29487470-7 2017 Mean QTc was significantly longer among patients with CD4 count <200 cells/mm3 than among those with >200 cells/mm3 0.445 +- 0.03secs vs 0.421 +- 0.03secs (P<0.001). qtc 5-8 CD4 molecule Homo sapiens 54-57 28912075-14 2018 The ratio of Tp-Te to QTc was also significantly increased after pulse steroid therapy (0,18+-0,03 vs 0,20+-0,03 p:0,009). qtc 22-25 transmembrane phosphatase with tensin homology Homo sapiens 13-18 28703863-5 2017 Sodium-glucose co-transporter-2 inhibitor treatment reversed QTc dispersion more in participants who had larger QTc dispersion before the treatment. qtc 61-64 solute carrier family 5 member 2 Homo sapiens 0-31 28703863-5 2017 Sodium-glucose co-transporter-2 inhibitor treatment reversed QTc dispersion more in participants who had larger QTc dispersion before the treatment. qtc 112-115 solute carrier family 5 member 2 Homo sapiens 0-31 27986658-7 2017 In vivo, isoproterenol infusion led to increased NADH in the heart along with QTc prolongation in wild-type mice; regardless of the approach, our data show that Kvbeta1.1 recognizes NADH changes and modulates Kv4.2 currents affecting AP and QTc durations. qtc 78-81 potassium voltage-gated channel, shaker-related subfamily, beta member 1 Mus musculus 161-170 28720088-1 2017 BACKGROUND: Sequence variants in the NOS1AP gene have repeatedly been reported to influence QTc, albeit with moderate effect sizes. qtc 92-95 nitric oxide synthase 1 adaptor protein Homo sapiens 37-43 28720088-3 2017 Here we assess three non-coding NOS1AP sequence variants, chosen for their previously reported strong association with QTc in normal and LQTS populations, for association with QTc in two Swedish LQT1 founder populations. qtc 119-122 nitric oxide synthase 1 adaptor protein Homo sapiens 32-38 28720088-3 2017 Here we assess three non-coding NOS1AP sequence variants, chosen for their previously reported strong association with QTc in normal and LQTS populations, for association with QTc in two Swedish LQT1 founder populations. qtc 176-179 nitric oxide synthase 1 adaptor protein Homo sapiens 32-38 28452189-6 2017 dAMPH elicited increased heart rate and corrected QT time (QTc) prolongation in both groups (all P < 0.001, QTc = 502 in one individual). qtc 59-62 Amphiphysin Drosophila melanogaster 0-5 27893184-15 2017 CACNA1C rs1006737 may modulate QTc in patients treated with psychotropic drugs. qtc 31-34 calcium voltage-gated channel subunit alpha1 C Homo sapiens 0-7 28024277-9 2017 CONCLUSIONS: Insulin-induced hypoglycaemia frequently causes abnormal QT prolongation and is associated with hypokalaemia and sympathoadrenal activation, thereby increasing the potential risk for ventricular arrhythmias, particularly in individuals with pre-existing high normal QTc. qtc 279-282 insulin Homo sapiens 13-20 28079193-7 2016 The QTc was 26 ms longer in SLE compared with RA (p=0.002) in the setting of a higher percentage of women, blacks, Hispanics and higher C reactive protein levels in the SLE group. qtc 4-7 C-reactive protein Homo sapiens 136-154 25922419-5 2015 After whole-exome sequencing and variant filtration, a homozygous p.D18fs*13 TRDN-encoded triadin frameshift mutation was discovered in a 10-year-old female patient with LQTS with a QTc of 500 milliseconds who experienced recurrent exertion-induced syncope/cardiac arrest beginning at 1 year of age. qtc 182-185 triadin Homo sapiens 77-81 27390944-11 2016 TS-associated mutations localize to specific areas of CACNA1C and are associated with a younger age at presentation, higher QTc, and 2:1 AV block than isolated LQTS-associated mutations. qtc 124-127 calcium voltage-gated channel subunit alpha1 C Homo sapiens 54-61 26887900-8 2016 Following LCSD, there was a 57 +- 35 ms decrease in QTc in LQT1 (P = .16) and 23 +- 21 ms decrease in QTc in LQT2 (P = .3). qtc 52-55 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 59-63 26887900-8 2016 Following LCSD, there was a 57 +- 35 ms decrease in QTc in LQT1 (P = .16) and 23 +- 21 ms decrease in QTc in LQT2 (P = .3). qtc 102-105 potassium voltage-gated channel subfamily H member 2 Homo sapiens 109-113 26645264-4 2016 Here, we aimed to research the relation between QTc, hepatic steatosis, and CIMT among obese children. qtc 48-51 CIMT Homo sapiens 76-80 26645264-14 2016 CONCLUSION: We demonstrated that obese children had higher CIMT and QTc values as well as more frequent hepatosteatosis, and that the presence of hepatosteatosis or increased CIMT had an association with prolonged QTc values in obese children. qtc 214-217 CIMT Homo sapiens 175-179 26645264-15 2016 Therefore, with the aim of detecting cardiovascular effects of obesity, it may be beneficial to perform the measurements of QTc in the presence of hepatosteatosis and/or increased CIMT among obese children. qtc 124-127 CIMT Homo sapiens 180-184 26858093-8 2016 The ability of a clinico-genetic model incorporating the two IL1B polymorphisms to classify patients at risk for developing prolonged postoperative QTc was superior to a clinical model alone, with a net reclassification improvement of 0.308 (P = 0.0003) and an integrated discrimination improvement of 0.02 (P = 0.000024). qtc 148-151 interleukin 1 beta Homo sapiens 61-65 26952045-7 2016 Kcne2 deletion, despite increasing normalized heart weight and prolonging baseline QTc by 70%, helped preserve post-infarct cardiac function (quantified by a Millar catheter), with parameters including left ventricular maximum pressure, max dP/dt (P < 0.01), contractility index, and pressure/time index (P < 0.05) all greater in Kcne2-/- compared with Kcne2+/+ mice. qtc 83-86 potassium voltage-gated channel, Isk-related subfamily, gene 2 Mus musculus 0-5 25922419-5 2015 After whole-exome sequencing and variant filtration, a homozygous p.D18fs*13 TRDN-encoded triadin frameshift mutation was discovered in a 10-year-old female patient with LQTS with a QTc of 500 milliseconds who experienced recurrent exertion-induced syncope/cardiac arrest beginning at 1 year of age. qtc 182-185 triadin Homo sapiens 90-97 25692020-10 2015 The results indicate that oxytocin has very low risk for eliciting QTc and APD prolongation directly, and infer that the QTc changes observed in vivo may be attributed to an indirect mechanism. qtc 67-70 oxytocin/neurophysin I prepropeptide Homo sapiens 26-34 25576780-11 2015 The second AED rescue occurred in a remotely symptomatic 14-year-old boy with high-risk LQT2 (QTc >550 ms) on a beta-blocker who previously declined a prophylactic ICD. qtc 94-97 potassium voltage-gated channel subfamily H member 2 Homo sapiens 88-92 25426817-5 2015 Fetal rhythm phenotype and postnatal QTc can predict postnatal rhythm and suggest genotype: bradycardic fetuses usually have KCNQ1 mutation, while those with TdP and/or a postnatal QTc more than 500 ms have SCN5A, KCNH2 or uncharacterized mutations. qtc 37-40 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 125-130 24388024-6 2014 Seventeen percent of patients given 5HT3R antagonists (n=242) and 22% of controls (n=220) had postoperative QTc exceeding 500 milliseconds. qtc 108-111 5-hydroxytryptamine receptor 3A Homo sapiens 36-41 24589909-8 2014 QTc was significantly longer in patients with ABCB1 3435CT+3435 TT than in those with 3435CC (P=0.006). qtc 0-3 ATP binding cassette subfamily B member 1 Homo sapiens 46-51 24059284-5 2014 PD patients with QTc dispersion longer than 65 ms had higher levels of serum ferritin (p = 0.038) and transferrin saturation (TSAT; p = 0.022) than the others. qtc 17-20 transferrin Homo sapiens 102-113 24388024-10 2014 The QTc was prolonged, but not significantly, in diabetic patients given 5HT3R antagonists (P=.16). qtc 4-7 5-hydroxytryptamine receptor 3A Homo sapiens 73-78 24097136-10 2014 Age (beta = 0.231, P < 0.001), gender (beta = 0.137, P = 0.008) and CRP (beta = 0.144, P = 0.006) associated independently with QTc in RA patients. qtc 131-134 C-reactive protein Homo sapiens 71-74 25525305-8 2014 The mean SAA concentration was significantly higher in patients treated with glucocorticoids, was inversely associated with QTc duration, and was markedly higher in patients with atherosclerotic plaques, emphasizing increased CV risk. qtc 124-127 serum amyloid A1 cluster Homo sapiens 9-12 23474828-8 2013 Both 5 and 10 mIU/kg/min insulin infusion prolonged significantly QTend, QTc, and Tpeak-Tend intervals. qtc 73-76 insulin Homo sapiens 25-32 23856471-6 2013 The KCNQ1 rs2074238 T-allele was significantly associated with a decreased risk of symptoms 0.34 (0.19-0.61; P<0.0002) and with shorter QTc (P<0.0001) in the combined discovery and replication cohorts. qtc 139-142 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 4-9 23094878-8 2012 This faster QT dynamic response of the QT-RR dynamic coupling remained in LQT-1 patients with QTc in a normal range (<430 ms). qtc 94-97 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 74-79 23153844-9 2012 CONCLUSIONS: These findings suggest that simulated repolarization can be used to predict clinical outcomes and to improve risk stratification in patients with LQT1, with a more pronounced effect among patients with a lower-range QTc, in whom a patient"s individual QTc may provide less incremental prognostic information. qtc 229-232 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 159-163 23153844-9 2012 CONCLUSIONS: These findings suggest that simulated repolarization can be used to predict clinical outcomes and to improve risk stratification in patients with LQT1, with a more pronounced effect among patients with a lower-range QTc, in whom a patient"s individual QTc may provide less incremental prognostic information. qtc 265-268 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 159-163 23668737-11 2013 Patients with a significant (>=10%) increase in BNP were more likely to have a significant (>=10%) increase in QTc and had a longer QTc at 3 months than those without. qtc 117-120 natriuretic peptide B Homo sapiens 51-54 23668737-13 2013 Among patients with an increase in BNP of >=10%, those with an increase in QTc of >=10% were several-fold more likely to experience SCD compared with those without, whereas there was no such association between the change in QTc and SCD among patients without an increase in BNP of >=10%. qtc 231-234 natriuretic peptide B Homo sapiens 35-38 21712262-5 2011 During the tachycardia phase following adenosine, QTc increased to 620 ms. Genetic analysis revealed a rare heterozygous polymorphism in KCNE1 predicting the substitution of asparagine for aspartic acid at position 85 of minK (D85N). qtc 50-53 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 137-142 21701401-5 2011 Stepwise linear regression selected fasting insulin as the strongest predictor for QTc, HOMA as the strongest predictor of average CIMT, and fasting glucose as the strongest predictor of total coronary lesion number and score. qtc 83-86 insulin Homo sapiens 44-51 21961484-6 2011 The relationships between the QTc interval and plasma exenatide, glucose, and insulin concentrations were also explored. qtc 30-33 insulin Homo sapiens 78-85 21798421-7 2011 The average QTc was 314 +- 23 ms. A mutation in genes related to SQTS was found in 23% of the probands; most of them had a gain of function mutation in HERG (SQTS1). qtc 12-15 potassium voltage-gated channel subfamily H member 2 Homo sapiens 152-156 21241800-3 2011 We identified a KCNQ1 missense mutation, KCNQ1 S277L, in a patient presenting with recurrent syncope triggered by emotional stress (QTc=528ms). qtc 132-135 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 16-21 20547773-6 2011 The results showed that drugs in group 1 induced greater inhibition of human ether-a-go-go-related gene (HERG) potassium current or the rapid component of the delayed rectifier potassium current (I(kr)), had lower half-maximal inhibitory concentration (IC50) values for inhibition of HERG/I(kr), and induced greater QTc increases in humans. qtc 316-319 potassium voltage-gated channel subfamily H member 2 Homo sapiens 105-109 21241800-3 2011 We identified a KCNQ1 missense mutation, KCNQ1 S277L, in a patient presenting with recurrent syncope triggered by emotional stress (QTc=528ms). qtc 132-135 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 41-46 19713541-8 2009 More patients with cTnI >or=0.3 ng/mL had prolonged QTc on early (63% versus 30%, P<0.0001) and late electrocardiography (24% versus 7%, P=0.024). qtc 55-58 troponin I3, cardiac type Homo sapiens 19-23 20226272-9 2010 LQT1 patients began the recovery period at a QTc of 492 +/- 11 ms, after which the QTc decreased by 33 +/- 11 ms during recovery. qtc 45-48 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 0-4 20435235-3 2010 OBJECTIVE: This study evaluated QTc-interval changes after administration of a single oral dose of flecainide, with and without paroxetine, in relation to CYP2D6 genetic polymorphism. qtc 32-35 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 155-161 19684871-3 2008 METHODS AND RESULTS: Mutational analysis of SNTA1 was performed on 39 LQTS patients (QTc> or =480 ms) with previously negative genetic screening for the known LQTS-causing genes. qtc 85-88 syntrophin alpha 1 Homo sapiens 44-49 18692916-1 2009 In a 34-year-old man showing short QT interval (QTc 329 ms), we identified a novel C-terminal KCNH2 mutation, R1135H. qtc 48-51 potassium voltage-gated channel subfamily H member 2 Homo sapiens 94-99 19281438-9 2009 QTc was significantly longer in patients with BGL > 8 mmol/L than in those with lower BGL (0.471 v 0.442 s, P < 0.001). qtc 0-3 LPS responsive beige-like anchor protein Homo sapiens 89-92 19281438-11 2009 CONCLUSIONS: There was a moderate, significant correlation between QTc and BGL. qtc 67-70 LPS responsive beige-like anchor protein Homo sapiens 75-78 19140916-7 2009 It was also higher in the non-LQT1 than in LQT1 patients (23.00 +/- 9.05 vs 8.74 +/- 1.56 ms; P < 0.001) and correlated positively with QTc in LQTS (r = 0.623, P < 0.002). qtc 139-142 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 43-47 19140916-12 2009 CONCLUSIONS: QTV is elevated in LQTS patients and is correlated with QTc in LQTS. qtc 69-72 QTV Homo sapiens 13-16 18808722-9 2008 KCNH2 SNP K897T was reported to exert a modifying effect on QTc, but it remains controversial whether it confers a risk or protective effect. qtc 60-63 potassium voltage-gated channel subfamily H member 2 Homo sapiens 0-5 19550362-4 2009 The purpose of this study is to evaluate QTc-DAT relation in healthy young adults. qtc 41-44 solute carrier family 6 member 3 Homo sapiens 45-48 19550362-12 2009 QTc-DAT and QTk-DAT relations were significant, r = -0.50, P = 0.004 and r = -0.59, P = 0.0002, respectively. qtc 0-3 solute carrier family 6 member 3 Homo sapiens 4-7 19550362-14 2009 CONCLUSION: This study suggests significant physiological QTc-DAT relation in young healthy adults. qtc 58-61 solute carrier family 6 member 3 Homo sapiens 62-65 19281438-6 2009 A moderate, positive correlation was found between QTc and BGL (Pearson"s correlation coefficient, r = 0.277, P < 0.001). qtc 51-54 LPS responsive beige-like anchor protein Homo sapiens 59-62 19281438-8 2009 In the cohort with QTc > 0.44 s, BGL was significantly higher, as were the need for inotropes, APACHE II scores and mortality. qtc 19-22 LPS responsive beige-like anchor protein Homo sapiens 36-39 19281438-9 2009 QTc was significantly longer in patients with BGL > 8 mmol/L than in those with lower BGL (0.471 v 0.442 s, P < 0.001). qtc 0-3 LPS responsive beige-like anchor protein Homo sapiens 46-49 19149796-7 2009 RESULTS: Within KCNQ1 there was weak evidence for association between the minor allele of IVS12 +14T>C and increased QTc (P = 0.02). qtc 120-123 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 16-21 17254595-3 2007 METHODS: This is and observational and prospective study in which we evaluated the prognostic implications of the QTc obtained at admission (AQTc) in the short- and long-term of the NST-ACS. qtc 114-117 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 186-189 18071169-3 2007 To compare the effects of 3 known hERG-associated channel blockers on the corrected QT (QTc), we conducted a randomized, controlled trial of opioid-addicted subjects. qtc 88-91 ETS transcription factor ERG Homo sapiens 34-38 17611010-5 2007 Statistically significant result for CYP1A2(*)1F was noted for all patients receiving chlorpromazine equivalent doses of above 300 mg and also for a further subgroup on antipsychotics known to be CYP1A2 substrates (p=0.007, mean QTc in ms for A/A: 395.5+/-15.1, A/C: 425.7+/-25.1, C/C: 427.3+/-20.7). qtc 229-232 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 37-43 16750469-22 2006 Prospective, large studies with a placebo and active control group are needed to evaluate the effect of beta2 agonists on QTc using formulas other than Bazett. qtc 122-125 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 104-109 16769256-2 2006 We report findings of a study of the relationship between QTc, increased QTc (> 440 ms) and angiotensin-converting enzyme (ACE) genotype in a multiethnic, population-based study completed in rural Hawaii. qtc 58-61 angiotensin I converting enzyme Homo sapiens 95-124 16769256-2 2006 We report findings of a study of the relationship between QTc, increased QTc (> 440 ms) and angiotensin-converting enzyme (ACE) genotype in a multiethnic, population-based study completed in rural Hawaii. qtc 58-61 angiotensin I converting enzyme Homo sapiens 126-129 16769256-2 2006 We report findings of a study of the relationship between QTc, increased QTc (> 440 ms) and angiotensin-converting enzyme (ACE) genotype in a multiethnic, population-based study completed in rural Hawaii. qtc 73-76 angiotensin I converting enzyme Homo sapiens 95-124 16769256-2 2006 We report findings of a study of the relationship between QTc, increased QTc (> 440 ms) and angiotensin-converting enzyme (ACE) genotype in a multiethnic, population-based study completed in rural Hawaii. qtc 73-76 angiotensin I converting enzyme Homo sapiens 126-129 16627447-6 2006 The predictive ability of QTc reflects an association between QTc and the following variables: BNP, left ventricular mass, and left ventricular ejection fraction (but not diastolic filling patterns). qtc 26-29 natriuretic peptide B Homo sapiens 95-98 16627447-6 2006 The predictive ability of QTc reflects an association between QTc and the following variables: BNP, left ventricular mass, and left ventricular ejection fraction (but not diastolic filling patterns). qtc 62-65 natriuretic peptide B Homo sapiens 95-98 16247790-6 2005 RESULTS: CHOP induced transient increases in the left ventricular end-diastolic diameter in an echocardiogram, the QTc interval and QTc dispersion in an electrocardiogram, and in the plasma brain and atrial natriuretic peptides. qtc 115-118 DNA damage inducible transcript 3 Homo sapiens 9-13 16247790-6 2005 RESULTS: CHOP induced transient increases in the left ventricular end-diastolic diameter in an echocardiogram, the QTc interval and QTc dispersion in an electrocardiogram, and in the plasma brain and atrial natriuretic peptides. qtc 132-135 DNA damage inducible transcript 3 Homo sapiens 9-13 16275192-5 2005 In contrast, QTc was significantly and consistently longer in subjects with LQT1 compared with controls during and after exercise (492 +/- 40 vs 407 +/- 14 ms, p <0.0001, at peak exercise; 498 +/- 30 vs 399 +/- 20 ms, p <0.0001, at 1 minute into recovery) or epinephrine (623 +/- 51 vs 499 +/- 51 ms, p <0.001, at peak epinephrine; 604 +/- 36 vs 507 +/- 54 ms, p <0.01, at 1 minute into recovery) but not in subjects with LQT2. qtc 13-16 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 76-80 16253912-8 2005 All genotype-negative LQTS cases hosting ANK2 variants had been diagnosed as "atypical" or "borderline" cases, most presenting with normal QTc, nonexertional syncope, U waves, and/or sinus bradycardia. qtc 139-142 ankyrin 2 Homo sapiens 41-45 16266404-11 2005 These results demonstrate that, in addition to polygenic background, dietary factors and other covariables, the KCNE1 G38S variant is involved in determining QTc levels in this population-based sample of families. qtc 158-161 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 112-117 15791034-16 2005 In normoglycemic female subjects, insulin resistance was an independent determinant of the prolongation of QTc. qtc 107-110 insulin Homo sapiens 34-41 16006297-4 2005 Analysis was performed to determine whether improvement in weight, in insulin resistance, or in FFAs has the greatest effect on reducing the QTc interval. qtc 141-144 insulin Homo sapiens 70-77 16006297-7 2005 QTc in the low-carbohydrate group correlated with improvement in insulin resistance, but this finding was not significant after correction for the greater weight loss. qtc 0-3 insulin Homo sapiens 65-72 15791034-3 2005 However, the relationship between insulin resistance and QTc is not clarified in non-diabetic healthy people. qtc 57-60 insulin Homo sapiens 34-41 16022964-10 2005 A QTc of > or =0.44 s at the lowest HR (sensitivity 100%; specificity 88.4%) and DeltaQT > or =60 ms (sensitivity 100%; specificity 82.6%) were good predictors for having LQT3. qtc 2-5 sodium voltage-gated channel alpha subunit 5 Homo sapiens 177-181 15791034-4 2005 The present study was performed to observe the association between QTc and insulin resistance in Korean non-diabetic subjects. qtc 67-70 insulin Homo sapiens 75-82 12715841-6 2003 In HC-D, the maximum QTc and the minimum QTc were greater than the control, which produced QTc dispersion similar to that in the control. qtc 21-24 DIH1 Homo sapiens 3-7 15334377-10 2004 The QTc also correlated positively with the systolic (SBP) and diastolic blood pressure (DBP) (r = 0.4371, P <.0001, r = 0.3632, P =.0014, respectively). qtc 4-7 selenium binding protein 1 Homo sapiens 54-57 15685300-4 2005 Changing from supine to standing alone caused a significant increase in QTc in the LQT2 group compared with in control subjects (change in QTc of 48+/-38 ms versus 21+/-29 ms, respectively, P=0.02). qtc 72-75 potassium voltage-gated channel subfamily H member 2 Homo sapiens 83-87 15384024-9 2004 Thirty-eight PD patients with QTc dispersion longer than 74 ms had lower blood pressure ( P = 0.01), fewer left ventricle masses ( P = 0.036), and lower serum albumin levels (P = 0.046) but higher levels of serum calcium (P = 0.038) and transferrin saturation (TSAT; P = 0.022) than the other patients. qtc 30-33 transferrin Homo sapiens 237-248 14506615-0 2003 C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. qtc 85-88 C-reactive protein Homo sapiens 0-18 12715841-6 2003 In HC-D, the maximum QTc and the minimum QTc were greater than the control, which produced QTc dispersion similar to that in the control. qtc 41-44 DIH1 Homo sapiens 3-7 12715841-6 2003 In HC-D, the maximum QTc and the minimum QTc were greater than the control, which produced QTc dispersion similar to that in the control. qtc 41-44 DIH1 Homo sapiens 3-7 8593946-4 1996 Because insulin is known to stimulate sympathetic activity, we studied the association of insulin level and glucose tolerance with QTc. qtc 131-134 insulin Homo sapiens 8-15 12004990-6 2002 However, 9 (47%) of 19 KVLQT1-genotyped LQT1 patients had a nondiagnostic resting QTc (<460 milliseconds), whereas 11 (41%) of 27 controls had a resting QTc higher than 440 milliseconds. qtc 82-85 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 23-29 12004990-6 2002 However, 9 (47%) of 19 KVLQT1-genotyped LQT1 patients had a nondiagnostic resting QTc (<460 milliseconds), whereas 11 (41%) of 27 controls had a resting QTc higher than 440 milliseconds. qtc 82-85 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 25-29 12004990-6 2002 However, 9 (47%) of 19 KVLQT1-genotyped LQT1 patients had a nondiagnostic resting QTc (<460 milliseconds), whereas 11 (41%) of 27 controls had a resting QTc higher than 440 milliseconds. qtc 156-159 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 23-29 12004990-6 2002 However, 9 (47%) of 19 KVLQT1-genotyped LQT1 patients had a nondiagnostic resting QTc (<460 milliseconds), whereas 11 (41%) of 27 controls had a resting QTc higher than 440 milliseconds. qtc 156-159 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 25-29 12004990-13 2002 Low-dose epinephrine infusion distinguishes controls from patients with concealed LQT1 manifesting an equivocal QTc at rest. qtc 112-115 potassium voltage-gated channel subfamily Q member 1 Homo sapiens 82-86 11551001-8 2001 Hypertension, serum cholesterol, obesity, heart rate, and fasting C-peptide and serum insulin levels were associated with prolonged QTc (all: P < or = 0.05). qtc 132-135 insulin Homo sapiens 86-93 8593946-0 1996 QTc duration is associated with levels of insulin and glucose intolerance. qtc 0-3 insulin Homo sapiens 42-49 12503836-3 2002 The present study aimed to evaluate the influence of dose and plasma concentration of thioridazine and CYP2D6 enzyme status on the QTc interval in psychiatric patients. qtc 131-134 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 103-109 11080065-11 2000 After adjustment for body size, resting QTc was directly related to fasting plasma insulin (partial r = 0.43, P = 0.01); furthermore, QTc was inversely related to serum potassium levels both in the fasting state (partial r = -0.16, P < 0. qtc 40-43 insulin Homo sapiens 83-90 10546040-0 1999 Fasting serum insulin concentrations are associated with QTc duration independent of serum leptin, percent body fat, and BMI. qtc 57-60 insulin Homo sapiens 14-21 10496453-2 1999 Both beta1-selective and nonselective beta-adrenergic blockade reduced QTc dispersion equally in patients with dilated cardiomyopathy. qtc 71-74 potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens 5-10 9428258-0 1997 Association of insulin with QTc dispersion. qtc 28-31 insulin Homo sapiens 15-22 8593946-4 1996 Because insulin is known to stimulate sympathetic activity, we studied the association of insulin level and glucose tolerance with QTc. qtc 131-134 insulin Homo sapiens 90-97 8593946-6 1996 QTc was significantly associated with fasting glucose, insulin, and C-peptide and glucose levels 60 and 120 min after an oral glucose load. qtc 0-3 insulin Homo sapiens 55-62 7715292-6 1995 QTc dispersion fell significantly from early to late ECGs in survivors (110.9 [48.5] to 76.5 [28.8] ms1/2), but not in patients who died during follow-up (108.0 [51.0] to 98.9 [43.1] ms1/2). qtc 0-3 MS Homo sapiens 183-188 7715292-6 1995 QTc dispersion fell significantly from early to late ECGs in survivors (110.9 [48.5] to 76.5 [28.8] ms1/2), but not in patients who died during follow-up (108.0 [51.0] to 98.9 [43.1] ms1/2). qtc 0-3 MS Homo sapiens 100-105 33181835-6 2021 Patients with SCD and either myocardial fibrosis or increased QTc displayed greater IL18 gene expression in peripheral blood mononuclear cells (PBMC), with QTc strongly correlated with plasma IL-18 levels. qtc 62-65 interleukin 18 Homo sapiens 84-88 33759309-10 2021 Utilizing linear regression, QTc has a positive correlation with Log-GDF-15 (r=0.216, p=1.0x10-6 ). qtc 29-32 growth differentiation factor 15 Homo sapiens 69-75 8306587-5 1993 QTc was greater than 0.440 s in 7.6% (95% CI 2.9-12.3) of control subjects, 25.6% (21.0-30.0) of diabetic patients, 30.8% (21.5-40.1) of DAN+, 23.9% (18.9-28.9) of DAN-. qtc 0-3 NBL1, DAN family BMP antagonist Homo sapiens 137-140 8306587-5 1993 QTc was greater than 0.440 s in 7.6% (95% CI 2.9-12.3) of control subjects, 25.6% (21.0-30.0) of diabetic patients, 30.8% (21.5-40.1) of DAN+, 23.9% (18.9-28.9) of DAN-. qtc 0-3 NBL1, DAN family BMP antagonist Homo sapiens 164-167 8306587-6 1993 QTc was greater than 0.460 s (mean + 2SD of QTc in control subjects) in 11.7% (8.5-14.9) of diabetic patients, 18.1% (10.3-25.9) of DAN+, 9.6% (6.2-13.0) of DAN-. qtc 0-3 NBL1, DAN family BMP antagonist Homo sapiens 132-135 8306587-6 1993 QTc was greater than 0.460 s (mean + 2SD of QTc in control subjects) in 11.7% (8.5-14.9) of diabetic patients, 18.1% (10.3-25.9) of DAN+, 9.6% (6.2-13.0) of DAN-. qtc 0-3 NBL1, DAN family BMP antagonist Homo sapiens 157-160 33929896-9 2021 In vivo FGFR4 blockade ameliorated the arrhythmogenic and QTc prolonging effects of FGF23. qtc 58-61 fibroblast growth factor receptor 4 Mus musculus 8-13 33929896-9 2021 In vivo FGFR4 blockade ameliorated the arrhythmogenic and QTc prolonging effects of FGF23. qtc 58-61 fibroblast growth factor 23 Mus musculus 84-89 33181835-6 2021 Patients with SCD and either myocardial fibrosis or increased QTc displayed greater IL18 gene expression in peripheral blood mononuclear cells (PBMC), with QTc strongly correlated with plasma IL-18 levels. qtc 62-65 interleukin 18 Homo sapiens 192-197 33064338-10 2021 In a univariate regression analysis, body mass index, smoking status, Tp-Te, and Tp-Te/QTc were significantly associated with the severity of AHI in OSA. qtc 87-90 transmembrane phosphatase with tensin homology Homo sapiens 81-86 33533258-8 2021 Subjects who were anti-Ro/SSA-positive showed an increased prevalence of QTc prolongation, in the presence of other concomitant risk factors (crude odds ratios [OR], 1.67 [1.26-2.21] for QTc >470/480 ms; 2.32 [1.54-3.49] for QTc >490 ms; 2.77 [1.66-4.60] for QTc >500 ms), independent of a connective tissue disease history. qtc 73-76 tripartite motif containing 21 Homo sapiens 23-29 33533258-8 2021 Subjects who were anti-Ro/SSA-positive showed an increased prevalence of QTc prolongation, in the presence of other concomitant risk factors (crude odds ratios [OR], 1.67 [1.26-2.21] for QTc >470/480 ms; 2.32 [1.54-3.49] for QTc >490 ms; 2.77 [1.66-4.60] for QTc >500 ms), independent of a connective tissue disease history. qtc 187-190 tripartite motif containing 21 Homo sapiens 23-29 33533258-10 2021 Nevertheless, stepwise-fully adjusted OR for the higher cutoffs remained significantly increased in anti-Ro/SSA-positive subjects, particularly for QTc >500 ms (2.27 [1.34-3.87]). qtc 148-151 tripartite motif containing 21 Homo sapiens 105-111 32530547-8 2021 Optimal QTc cut-off for prediction of CA/VA was >=480ms. qtc 8-11 carbonic anhydrase 5A Homo sapiens 38-43