PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33887199-0 2021 Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: the polyG diseases. polyglycine 50-61 gamma-glutamylcyclotransferase Homo sapiens 15-18 33887199-6 2021 These results suggest that translation of expanded GGC repeats into a novel and pathogenic polyglycine-containing protein underlies the presence of intranuclear inclusions and neurodegeneration in NIID. polyglycine 91-102 gamma-glutamylcyclotransferase Homo sapiens 51-54 33086983-4 2021 Methods and Results: We generated transgenic mice with expression of CaV1.2 alpha1C subunits with: 1) mutations ablating interaction between alpha1C and beta subunits; 2) flexibility-inducing polyglycine substitutions in the I-II loop (GGG-alpha1C); or 3) introduction of the alternatively spliced 25-amino acid exon 9* mimicking a splice variant of alpha1C up-regulated in the hypertrophied heart. polyglycine 192-203 B cell leukemia/lymphoma 2 related protein A1c Mus musculus 76-83 32101156-2 2020 Recently, it has been shown that CGG repeats trigger repeat associated non-AUG initiated translation (RAN) of a cryptic polyglycine-containing protein, FMRpolyG. polyglycine 120-131 RAN, member RAS oncogene family Homo sapiens 102-105 33693509-7 2021 Immunofluorescence on OPDM muscle samples and expressing mutant NOTCH2NLC with (GGC)69 repeat expansions in HEK293 cells indicated that mutant NOTCH2NLC-polyGlycine protein might be a major component of intranuclear inclusions, and contribute to toxicity in cultured cells. polyglycine 153-164 notch receptor 2 Homo sapiens 64-70 33693509-7 2021 Immunofluorescence on OPDM muscle samples and expressing mutant NOTCH2NLC with (GGC)69 repeat expansions in HEK293 cells indicated that mutant NOTCH2NLC-polyGlycine protein might be a major component of intranuclear inclusions, and contribute to toxicity in cultured cells. polyglycine 153-164 gamma-glutamylcyclotransferase Homo sapiens 80-83 33693509-7 2021 Immunofluorescence on OPDM muscle samples and expressing mutant NOTCH2NLC with (GGC)69 repeat expansions in HEK293 cells indicated that mutant NOTCH2NLC-polyGlycine protein might be a major component of intranuclear inclusions, and contribute to toxicity in cultured cells. polyglycine 153-164 notch receptor 2 Homo sapiens 143-149 30244968-5 2018 Gp38 contains rare polyglycine type II helices folded into a packed lattice, herein designated "PGII sandwich." polyglycine 19-30 hypothetical protein Salmonella phage vB_SenM-S16 0-4 30288524-1 2018 To improve gene transfection efficiency in vitro and in vivo, we first grafted polyglycine (PGly) onto branched polyethyleneimine (PEI) (molecular weight MW 25 kDa) to obtain a novel gene vector PGly-PEI (PPG), before complexing it with poly(ethylene glycol)-poly-l-glutamate (PEG-PLG) for adjusting the charge density of PEI. polyglycine 79-90 serglycin Homo sapiens 205-208 30288524-1 2018 To improve gene transfection efficiency in vitro and in vivo, we first grafted polyglycine (PGly) onto branched polyethyleneimine (PEI) (molecular weight MW 25 kDa) to obtain a novel gene vector PGly-PEI (PPG), before complexing it with poly(ethylene glycol)-poly-l-glutamate (PEG-PLG) for adjusting the charge density of PEI. polyglycine 79-90 plasminogen Homo sapiens 281-284 28948156-2 2017 Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. polyglycine 81-93 androgen receptor Homo sapiens 118-135 29971092-3 2018 Accumulation of toxic polyglycine (FMRpolyG), a by-product of the CGGexp repeat-associated non-ATG (RAN) translation, is considered to be one of the main factors triggering neurodegenerative processes in FXTAS patients. polyglycine 22-33 RAN, member RAS oncogene family Homo sapiens 100-103 28948156-2 2017 Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. polyglycine 95-101 androgen receptor Homo sapiens 118-135 26537920-0 2016 Presence of inclusions positive for polyglycine containing protein, FMRpolyG, indicates that repeat-associated non-AUG translation plays a role in fragile X-associated primary ovarian insufficiency. polyglycine 36-47 RAN, member RAS oncogene family Mus musculus 93-118 28722183-2 2017 Although polyproline or polyglycine type II helices (PPII or PGII ) are frequently found in proteins, they are not considered as equivalent secondary structure elements because they do not form a similar self-contained hydrogen-bonding network of the main chain atoms. polyglycine 24-35 decorin Homo sapiens 61-65 28762555-1 2017 The conformation of a family of alpha1 and alpha2 polyglycine-containing organo-polyoxometalates was determined through a mixed experimental/molecular dynamics approach. polyglycine 50-61 adrenoceptor alpha 1D Homo sapiens 32-49 28334513-3 2017 N-terminal transactivation domain of the encoded AR protein harbours two polymorphic stretches of identical amino acids, a polyglutamine tract (encoded by 8-37 CAG-repeats) and a polyglycine tract (encoded by 10-30 GGN-repeats). polyglycine 179-190 androgen receptor Homo sapiens 49-51 26537920-1 2016 STUDY QUESTION: Does repeat-associated non-AUG (RAN) translation play a role in fragile X-associated primary ovarian insufficiency (FXPOI), leading to the presence of polyglycine containing protein (FMRpolyG)-positive inclusions in ovarian tissue? polyglycine 167-178 RAN, member RAS oncogene family Mus musculus 21-46 26537920-1 2016 STUDY QUESTION: Does repeat-associated non-AUG (RAN) translation play a role in fragile X-associated primary ovarian insufficiency (FXPOI), leading to the presence of polyglycine containing protein (FMRpolyG)-positive inclusions in ovarian tissue? polyglycine 167-178 RAN, member RAS oncogene family Mus musculus 48-51 24991291-3 2014 The driving force of the supramer formation is hydrogen bonding, the polypeptide chain conformation is related to the folding of helical polyglycine II (PG II). polyglycine 137-151 decorin Homo sapiens 153-158 25954027-3 2015 However, recent studies demonstrate that the repeat also elicits production of a toxic polyglycine protein, FMRpolyG, via repeat-associated non-AUG (RAN)-initiated translation. polyglycine 87-98 Ran Drosophila melanogaster 149-152 25573245-1 2015 The rate constants for H-D exchange reactions of sodiated polyglycines (GnNa(+), n = 2-8) and polyalanines (AnNa(+), n = 2, 3 and 5) with ND3 have been measured in the cell of an FT-ICR mass spectrometer. polyglycine 58-70 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 138-141 25837709-7 2015 Plexin-B1 and -B3 TM helices are regular and tend to associate, whereas plexin-A1, -A2, -A3, -A4, -C1 and -D1 contain sequence elements, such as poly-Glycine or aromatic residues that distort helix conformation and association. polyglycine 145-157 plexin A1 Homo sapiens 72-109 21940984-1 2012 Androgen receptor (AR) CAG(n) (polyglutamine) and GGN(n) (polyglycine) repeat polymorphisms determine part of the androgenic effect and may influence adiposity. polyglycine 58-69 gametogenetin Homo sapiens 50-53 23664607-2 2013 (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles. polyglycine 197-208 RAN, member RAS oncogene family Homo sapiens 32-57 23664607-2 2013 (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles. polyglycine 197-208 RAN, member RAS oncogene family Homo sapiens 59-62 23664607-2 2013 (2013) reveal that noncanonical repeat associated non-AUG (RAN) translation occurs on nonexpanded (CGG)30-50 and premutation (CGG)59-160 repeats, associated with the FMR1 gene, suggesting that the polyglycine and polyalanine products might have natural and pathogenic roles. polyglycine 197-208 fragile X messenger ribonucleoprotein 1 Homo sapiens 166-170 23725463-2 2014 We investigated polyglutamine (CAG) and a polyglycine (GGC) tract in Italian men with defective spermatogenesis. polyglycine 42-53 gamma-glutamylcyclotransferase Homo sapiens 55-58 23836816-10 2013 We conclude that surface tethering of TbpB is required for optimal performance of the transferrin iron acquisition system, while the presence of the polyglycine stretch near the amino terminus of TbpB contributes significantly to transferrin iron transport function. polyglycine 149-160 transferrin Homo sapiens 230-241 23602499-3 2013 We explain this paradox by demonstrating that CGG repeats trigger repeat-associated non-AUG-initiated (RAN) translation of a cryptic polyglycine-containing protein, FMRpolyG. polyglycine 133-144 Ran Drosophila melanogaster 103-106 23039317-11 2012 The calculated conformational energies of these structures are unusually stable relative to all others, with energies significantly lower than the PGI/PGII conformations characteristic of polyglycine structures in solution and in the crystalline form, where intermolecular H-bonds play a role. polyglycine 188-199 progastricsin Homo sapiens 151-155 22101789-3 2012 The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. polyglycine 72-83 G1 to S phase transition 1 Homo sapiens 4-9 22101789-3 2012 The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. polyglycine 72-83 G1 to S phase transition 1 Homo sapiens 10-15 22101789-3 2012 The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. polyglycine 72-83 gamma-glutamylcyclotransferase Homo sapiens 48-51 19617210-1 2011 The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGN(n), polyglycine) or its transcriptional activity (CAG(n), polyglutamine). polyglycine 157-168 androgen receptor Homo sapiens 18-35 21074900-1 2012 Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). polyglycine 48-60 FUS RNA binding protein Homo sapiens 71-87 21074900-1 2012 Insertion and deletion variants (indels) within poly glycine tracts of fused in sarcoma (FUS) were initially reported as causative of disease in amyotrophic lateral sclerosis (ALS). polyglycine 48-60 FUS RNA binding protein Homo sapiens 89-92 21252283-1 2011 sFLT01 is a novel fusion protein that consists of the VEGF/PlGF (placental growth factor) binding domain of human VEGFR1/Flt-1 (hVEGFR1) fused to the Fc portion of human IgG(1) through a polyglycine linker. polyglycine 187-198 fms related receptor tyrosine kinase 1 Homo sapiens 114-120 21252283-1 2011 sFLT01 is a novel fusion protein that consists of the VEGF/PlGF (placental growth factor) binding domain of human VEGFR1/Flt-1 (hVEGFR1) fused to the Fc portion of human IgG(1) through a polyglycine linker. polyglycine 187-198 fms related receptor tyrosine kinase 1 Homo sapiens 121-126 21252283-1 2011 sFLT01 is a novel fusion protein that consists of the VEGF/PlGF (placental growth factor) binding domain of human VEGFR1/Flt-1 (hVEGFR1) fused to the Fc portion of human IgG(1) through a polyglycine linker. polyglycine 187-198 fms related receptor tyrosine kinase 1 Homo sapiens 128-135 19617210-1 2011 The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGN(n), polyglycine) or its transcriptional activity (CAG(n), polyglutamine). polyglycine 157-168 androgen receptor Homo sapiens 37-39 19963113-2 2009 GSPT1 contains a GGC(n) polymorphism in exon 1, encoding a polyglycine expansion in the N-terminal of the protein. polyglycine 59-70 G1 to S phase transition 1 Homo sapiens 0-5 20232451-7 2010 We further identified a novel in-frame insertion/deletion mutation in FUS exon 12 (p.S402_P411delinsGGGG) which is predicted to expand a conserved poly-glycine motif. polyglycine 147-159 FUS RNA binding protein Homo sapiens 70-73 19963113-2 2009 GSPT1 contains a GGC(n) polymorphism in exon 1, encoding a polyglycine expansion in the N-terminal of the protein. polyglycine 59-70 gamma-glutamylcyclotransferase Homo sapiens 17-20 19095061-1 2009 The exon 1 of the human androgen receptor (AR) gene contains two length polymorphisms of CAG (polyglutamine) and GGN (polyglycine). polyglycine 118-129 androgen receptor Homo sapiens 24-41 19383805-1 2009 OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene. polyglycine 75-86 androgen receptor Homo sapiens 21-38 19383805-1 2009 OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene. polyglycine 75-86 androgen receptor Homo sapiens 40-42 19383805-1 2009 OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene. polyglycine 75-86 gametogenetin Homo sapiens 164-167 19383805-1 2009 OBJECTIVE: The human androgen receptor (AR) contains a polyglutamine and a polyglycine stretch which are highly polymorphic and are coded respectively by a CAG and GGN repeat in exon 1 of the AR gene. polyglycine 75-86 androgen receptor Homo sapiens 192-194 19383805-10 2009 Although the present study thus adds credence to the view that the polyglycine tract in the AR can modulate AR action, this effect appears to be only small so that its clinical relevance remains questionable. polyglycine 67-78 androgen receptor Homo sapiens 92-94 19383805-10 2009 Although the present study thus adds credence to the view that the polyglycine tract in the AR can modulate AR action, this effect appears to be only small so that its clinical relevance remains questionable. polyglycine 67-78 androgen receptor Homo sapiens 108-110 19237593-4 2009 Here, we demonstrate that the IS6-alpha-interaction domain (AID) linker provides a rigid connection between the pore and Ca(V)beta/I-II loop complex by showing that IS6-AID linker polyglycine mutations accelerate Ca(V)1.2 (L-type) and Ca(V)2.1 (P/Q-type) VDI. polyglycine 180-191 carbonic anhydrase 5B Homo sapiens 121-130 19237593-4 2009 Here, we demonstrate that the IS6-alpha-interaction domain (AID) linker provides a rigid connection between the pore and Ca(V)beta/I-II loop complex by showing that IS6-AID linker polyglycine mutations accelerate Ca(V)1.2 (L-type) and Ca(V)2.1 (P/Q-type) VDI. polyglycine 180-191 immunoglobulin lambda variable 2-8 Homo sapiens 213-221 19237593-4 2009 Here, we demonstrate that the IS6-alpha-interaction domain (AID) linker provides a rigid connection between the pore and Ca(V)beta/I-II loop complex by showing that IS6-AID linker polyglycine mutations accelerate Ca(V)1.2 (L-type) and Ca(V)2.1 (P/Q-type) VDI. polyglycine 180-191 calcium voltage-gated channel subunit alpha1 A Homo sapiens 223-243 19261388-0 2009 The androgen receptor gene polyglycine repeat polymorphism is associated with memory performance in healthy Chinese individuals. polyglycine 27-38 androgen receptor Homo sapiens 4-21 19261388-5 2009 In the present study, we hypothesized that common variation in two functional polymorphisms in the androgen receptor gene, the polyglutamine (CAG) and/or polyglycine (GGN) repeats, would influence memory function in healthy subjects. polyglycine 154-165 androgen receptor Homo sapiens 99-116 19261388-5 2009 In the present study, we hypothesized that common variation in two functional polymorphisms in the androgen receptor gene, the polyglutamine (CAG) and/or polyglycine (GGN) repeats, would influence memory function in healthy subjects. polyglycine 154-165 gametogenetin Homo sapiens 167-170 18633446-3 2009 We have generated two novel chimeric VEGF-binding molecules, sFLT01 and sFLT02, which consist of the second immunoglobulin (IgG)-like domain of Flt-1 fused either to a human IgG1 Fc or solely to the CH3 domain of IgG1 Fc through a polyglycine linker 9Gly. polyglycine 231-242 vascular endothelial growth factor A Homo sapiens 37-41 18633446-3 2009 We have generated two novel chimeric VEGF-binding molecules, sFLT01 and sFLT02, which consist of the second immunoglobulin (IgG)-like domain of Flt-1 fused either to a human IgG1 Fc or solely to the CH3 domain of IgG1 Fc through a polyglycine linker 9Gly. polyglycine 231-242 fms related receptor tyrosine kinase 1 Homo sapiens 144-149 19095061-1 2009 The exon 1 of the human androgen receptor (AR) gene contains two length polymorphisms of CAG (polyglutamine) and GGN (polyglycine). polyglycine 118-129 androgen receptor Homo sapiens 43-45 19095061-1 2009 The exon 1 of the human androgen receptor (AR) gene contains two length polymorphisms of CAG (polyglutamine) and GGN (polyglycine). polyglycine 118-129 gametogenetin Homo sapiens 113-116 17728127-1 2007 The exon 1 of the human androgen receptor gene (AR) contains both CAG (polyglutamine) and GGN (polyglycine) repeat length polymorphisms. polyglycine 95-106 androgen receptor Homo sapiens 24-41 18638320-4 2008 Contrary to our expectations, echidna HOXA13 possesses a unique set of polyalanine tracts and an unprecedented polyglycine tract. polyglycine 111-122 homeobox A13 Homo sapiens 38-44 17728127-1 2007 The exon 1 of the human androgen receptor gene (AR) contains both CAG (polyglutamine) and GGN (polyglycine) repeat length polymorphisms. polyglycine 95-106 gametogenetin Homo sapiens 90-93 17583729-0 2007 Sequence composition effects on denatured state loop formation in iso-1-cytochrome c variants: polyalanine versus polyglycine inserts. polyglycine 114-125 eukaryotic translation initiation factor 1 Homo sapiens 66-71 17601880-1 2007 Genetic studies have reported association of a polyglycine-encoding GGN repeat in exon 1 of the androgen receptor (AR) gene with common human traits. polyglycine 47-58 androgen receptor Homo sapiens 96-113 17601880-1 2007 Genetic studies have reported association of a polyglycine-encoding GGN repeat in exon 1 of the androgen receptor (AR) gene with common human traits. polyglycine 47-58 androgen receptor Homo sapiens 115-117 17601880-1 2007 Genetic studies have reported association of a polyglycine-encoding GGN repeat in exon 1 of the androgen receptor (AR) gene with common human traits. polyglycine 47-58 gametogenetin Homo sapiens 68-71 17601880-2 2007 The polyglycine tract is located in the transactivating domain of the AR protein, suggesting an effect of repeat length on receptor function. polyglycine 4-15 androgen receptor Homo sapiens 70-72 15987717-0 2005 Polyglycine expansions in eRF3/GSPT1 are associated with gastric cancer susceptibility. polyglycine 0-11 G1 to S phase transition 1 Homo sapiens 31-36 16957138-0 2007 Association of long polyglycine tracts (GGN repeats) in exon 1 of the androgen receptor gene with cryptorchidism and penile hypospadias in Iranian patients. polyglycine 20-31 gametogenetin Homo sapiens 40-43 16957138-0 2007 Association of long polyglycine tracts (GGN repeats) in exon 1 of the androgen receptor gene with cryptorchidism and penile hypospadias in Iranian patients. polyglycine 20-31 androgen receptor Homo sapiens 70-87 17256155-4 2007 In one such replication study, it was claimed that the causative variant underlying the association was likely to be the polyglycine (GGN) repeat polymorphism, one of two apparently functional triplet repeat polymorphisms located in the exon 1 transactivating domain of the gene. polyglycine 121-132 gametogenetin Homo sapiens 134-137 17171659-2 2007 This sequence encodes polyalanine and polyglycine stretches within the N-terminal portion of MeCP2, and may confer novel functional properties to the protein. polyglycine 38-49 methyl-CpG binding protein 2 Homo sapiens 93-98 16187285-3 2006 The GGN repeat codifies for a polyglycine tract, and affects the amount of the AR protein transcribed. polyglycine 30-41 gametogenetin Homo sapiens 4-7 16187285-3 2006 The GGN repeat codifies for a polyglycine tract, and affects the amount of the AR protein transcribed. polyglycine 30-41 androgen receptor Homo sapiens 79-81 15987717-4 2005 The aim of this study was to evaluate eRF3/GSPT1 gene as a potential genetic susceptibility associated locus for gastric cancer, analysing a stable GGC expansion in exon 1 encoding a polyglycine tract in the N-terminal domain of the protein. polyglycine 183-194 G1 to S phase transition 1 Homo sapiens 43-48 15987717-4 2005 The aim of this study was to evaluate eRF3/GSPT1 gene as a potential genetic susceptibility associated locus for gastric cancer, analysing a stable GGC expansion in exon 1 encoding a polyglycine tract in the N-terminal domain of the protein. polyglycine 183-194 gamma-glutamylcyclotransferase Homo sapiens 148-151 15902657-4 2005 The investigation of a large number of genetic variants covering the AR locus suggests that a polyglycine-encoding GGN repeat in exon 1 is a plausible candidate for conferring the functional effect. polyglycine 94-105 gametogenetin Homo sapiens 115-118 14743468-1 2004 BACKGROUND: The amino-terminal transcriptional activation domain of the androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that encode polyglutamine (CAG)n and polyglycine (GGC)n tracts. polyglycine 192-203 androgen receptor Homo sapiens 72-89 15757859-2 2005 The androgen receptor has two polymorphic sites in exon 1, with different numbers of CAG and GGC repeats, resulting in variable lengths of polyglutamine and polyglycine stretches. polyglycine 157-168 androgen receptor Homo sapiens 4-21 15757859-2 2005 The androgen receptor has two polymorphic sites in exon 1, with different numbers of CAG and GGC repeats, resulting in variable lengths of polyglutamine and polyglycine stretches. polyglycine 157-168 gamma-glutamylcyclotransferase Homo sapiens 93-96 15044606-1 2004 The androgen receptor (AR) has two polymorphic sites in exon 1, characterized by different numbers of CAG and GGC repeats resulting in variable lengths of polyglutamine and polyglycine stretches. polyglycine 173-184 androgen receptor Homo sapiens 4-21 15044606-1 2004 The androgen receptor (AR) has two polymorphic sites in exon 1, characterized by different numbers of CAG and GGC repeats resulting in variable lengths of polyglutamine and polyglycine stretches. polyglycine 173-184 androgen receptor Homo sapiens 23-25 15044606-1 2004 The androgen receptor (AR) has two polymorphic sites in exon 1, characterized by different numbers of CAG and GGC repeats resulting in variable lengths of polyglutamine and polyglycine stretches. polyglycine 173-184 gamma-glutamylcyclotransferase Homo sapiens 110-113 14743468-1 2004 BACKGROUND: The amino-terminal transcriptional activation domain of the androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that encode polyglutamine (CAG)n and polyglycine (GGC)n tracts. polyglycine 192-203 androgen receptor Homo sapiens 91-93 14743468-1 2004 BACKGROUND: The amino-terminal transcriptional activation domain of the androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that encode polyglutamine (CAG)n and polyglycine (GGC)n tracts. polyglycine 192-203 gamma-glutamylcyclotransferase Homo sapiens 205-208 14652007-0 2003 The polyglycine and polyglutamine repeats in the androgen receptor gene in Japanese and Caucasian populations. polyglycine 4-15 androgen receptor Homo sapiens 49-66 14652007-1 2003 Human androgen receptor (AR) gene contains two polymorphic trinucleotide repeats of CAG and GGC, which code for polyglutamine and polyglycine tracts in the N-terminal domain in which the receptor activity resides. polyglycine 130-141 androgen receptor Homo sapiens 6-23 14652007-1 2003 Human androgen receptor (AR) gene contains two polymorphic trinucleotide repeats of CAG and GGC, which code for polyglutamine and polyglycine tracts in the N-terminal domain in which the receptor activity resides. polyglycine 130-141 androgen receptor Homo sapiens 25-27 14652007-1 2003 Human androgen receptor (AR) gene contains two polymorphic trinucleotide repeats of CAG and GGC, which code for polyglutamine and polyglycine tracts in the N-terminal domain in which the receptor activity resides. polyglycine 130-141 gamma-glutamylcyclotransferase Homo sapiens 92-95 10502720-1 1999 Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. polyglycine 187-198 androgen receptor Homo sapiens 103-120 11884127-1 2002 Bivalent peptidic thrombin inhibitors consisting of an N-terminal d-cyclohexylalanine-Pro-N(alpha)(Me)Arg active-site fragment, a flexible polyglycine linker, and a C-terminal hirugen-like segment directed towards the fibrinogen recognition exosite inhibit thrombin with K(i) values in the picomolar range, remaining stable in buffered solution at pH 7.8 for at least 15 hours. polyglycine 139-150 coagulation factor II, thrombin Homo sapiens 18-26 12045144-5 2002 According to the simulation results, a limited set of trinucleotides, that is, cgg, ccg, cag, and gaa repeats coding for polyalanine, polyglycine, polyproline, polyglutamine, and polylysine are prone to proliferation. polyglycine 134-145 alpha glucosidase Homo sapiens 98-101 11748846-0 2001 A survey of TWIST for mutations in craniosynostosis reveals a variable length polyglycine tract in asymptomatic individuals. polyglycine 78-89 twist family bHLH transcription factor 1 Homo sapiens 12-17 11016637-4 2000 Genomic DNA from 190 prostate cancer patients and 304 healthy controls was used for direct sequencing to evaluate the relationship of CAG and GGN (polyglycine) repeat length in the AR gene. polyglycine 147-158 androgen receptor Homo sapiens 181-183 11016637-7 2000 For the GGN tract (GGT3GGG1GGT2GGCn), based on the sequencing results from 481 samples, we are the first to show that although GGC regions in the polyglycine tract are highly variable, there are no mutations or polymorphisms in the GGT and GGG regions. polyglycine 146-157 gametogenetin Homo sapiens 8-11 10502720-1 1999 Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. polyglycine 187-198 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 122-125 10502720-1 1999 Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. polyglycine 187-198 gamma-glutamylcyclotransferase Homo sapiens 170-173 9730898-7 1998 We have attempted to define a minimal peptide on a polyglycine backbone that binds Qa-1b. polyglycine 51-62 histocompatibility 2, T region locus 23 Mus musculus 83-88 10341128-1 1999 Superslow backbone dynamics of the protein barstar and the polypeptide polyglycine was studied by means of a solid-state MAS 1D exchange NMR method (time-reverse ODESSA) that can detect reorientation of nuclei carrying anisotropic chemical shift tensors. polyglycine 71-82 MAS1 proto-oncogene, G protein-coupled receptor Homo sapiens 121-126 9610786-1 1998 The androgen receptor (AR) gene contains a polymorphic GGN microsatellite in exon 1, which encodes polyglycine in the amino terminus of the AR. polyglycine 99-110 androgen receptor Homo sapiens 4-21 9610786-1 1998 The androgen receptor (AR) gene contains a polymorphic GGN microsatellite in exon 1, which encodes polyglycine in the amino terminus of the AR. polyglycine 99-110 androgen receptor Homo sapiens 23-25 9610786-1 1998 The androgen receptor (AR) gene contains a polymorphic GGN microsatellite in exon 1, which encodes polyglycine in the amino terminus of the AR. polyglycine 99-110 gametogenetin Homo sapiens 55-58 9610786-1 1998 The androgen receptor (AR) gene contains a polymorphic GGN microsatellite in exon 1, which encodes polyglycine in the amino terminus of the AR. polyglycine 99-110 androgen receptor Homo sapiens 140-142 9619509-5 1998 In any case, these structures, e.g. beta-turns, polyglycine II and beta-conformations, are those previously suggested to participate to conformational equilibria of elastin. polyglycine 48-62 elastin Homo sapiens 165-172 2156268-5 1990 Both BAT2 and BAT3 are very rich in proline and include short tracts of polyproline, polyglycine, and charged amino acids. polyglycine 85-96 proline rich coiled-coil 2A Homo sapiens 5-9 1910688-11 1991 Recent experiments demonstrating that peptides with polyalanine, polyproline, or polyglycine bind well to MHC proteins have proven that the structural requirements for binding are quite minimal. polyglycine 81-92 major histocompatibility complex, class I, C Homo sapiens 106-109 9360540-1 1997 The X-linked androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that code for polyglutamine and polyglycine tracts in the N-terminal trans-activation domain of the AR protein. polyglycine 128-139 androgen receptor Homo sapiens 13-30 9360540-1 1997 The X-linked androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that code for polyglutamine and polyglycine tracts in the N-terminal trans-activation domain of the AR protein. polyglycine 128-139 androgen receptor Homo sapiens 32-34 9360540-1 1997 The X-linked androgen receptor (AR) gene contains two polymorphic trinucleotide repeat segments that code for polyglutamine and polyglycine tracts in the N-terminal trans-activation domain of the AR protein. polyglycine 128-139 androgen receptor Homo sapiens 196-198 8108136-1 1994 The NFKB-2 gene (previously LYT-10, NF-kappa Bp100 or NF-kappa Bp97) codes for a NF-kappa B/rel related protein which is highly homologous to NFKB-1 (previously NF-kappa Bp105) within its rel, poly-glycine and ankyrin domains. polyglycine 193-205 nuclear factor kappa B subunit 2 Homo sapiens 4-10 8108136-1 1994 The NFKB-2 gene (previously LYT-10, NF-kappa Bp100 or NF-kappa Bp97) codes for a NF-kappa B/rel related protein which is highly homologous to NFKB-1 (previously NF-kappa Bp105) within its rel, poly-glycine and ankyrin domains. polyglycine 193-205 nuclear factor kappa B subunit 2 Homo sapiens 28-34 8108136-1 1994 The NFKB-2 gene (previously LYT-10, NF-kappa Bp100 or NF-kappa Bp97) codes for a NF-kappa B/rel related protein which is highly homologous to NFKB-1 (previously NF-kappa Bp105) within its rel, poly-glycine and ankyrin domains. polyglycine 193-205 nuclear factor kappa B subunit 1 Homo sapiens 36-46 8108136-1 1994 The NFKB-2 gene (previously LYT-10, NF-kappa Bp100 or NF-kappa Bp97) codes for a NF-kappa B/rel related protein which is highly homologous to NFKB-1 (previously NF-kappa Bp105) within its rel, poly-glycine and ankyrin domains. polyglycine 193-205 nuclear factor kappa B subunit 1 Homo sapiens 142-148 8108136-1 1994 The NFKB-2 gene (previously LYT-10, NF-kappa Bp100 or NF-kappa Bp97) codes for a NF-kappa B/rel related protein which is highly homologous to NFKB-1 (previously NF-kappa Bp105) within its rel, poly-glycine and ankyrin domains. polyglycine 193-205 nuclear factor kappa B subunit 1 Homo sapiens 161-175 2156268-5 1990 Both BAT2 and BAT3 are very rich in proline and include short tracts of polyproline, polyglycine, and charged amino acids. polyglycine 85-96 BAG cochaperone 6 Homo sapiens 14-18 34646012-5 2021 Here we show that the cytokine-binding segments of human ALK and LTK comprise a novel architectural chimera of a permuted TNF-like module that braces a glycine-rich subdomain featuring a hexagonal lattice of long polyglycine type II helices. polyglycine 213-224 ALK receptor tyrosine kinase Homo sapiens 57-60 34694469-0 2021 Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases. polyglycine 67-78 notch receptor 2 Homo sapiens 33-39 34694469-0 2021 Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases. polyglycine 67-78 gamma-glutamylcyclotransferase Homo sapiens 43-46 34694469-0 2021 Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases. polyglycine 149-160 notch receptor 2 Homo sapiens 33-39 34694469-0 2021 Upstream open reading frame with NOTCH2NLC GGC expansion generates polyglycine aggregates and disrupts nucleocytoplasmic transport: implications for polyglycine diseases. polyglycine 149-160 gamma-glutamylcyclotransferase Homo sapiens 43-46 34819665-7 2021 We show that repetitive glycines in the GRD form rigid helices that separate the major ligand-binding site from a distal polyglycine extension loop (PXL) that mediates ALK dimerization. polyglycine 121-132 ALK receptor tyrosine kinase Homo sapiens 168-171 34646012-5 2021 Here we show that the cytokine-binding segments of human ALK and LTK comprise a novel architectural chimera of a permuted TNF-like module that braces a glycine-rich subdomain featuring a hexagonal lattice of long polyglycine type II helices. polyglycine 213-224 leukocyte receptor tyrosine kinase Homo sapiens 65-68 34081916-2 2021 (2021) show that a polyglycine-expanded protein, uN2CpolyG, is translated from an expansion of GGC repeats in the 5" UTR of the NOTCH2NLC (Notch homolog 2 N-terminal-like C) gene, defining a new pathological mechanism for neuronal intranuclear inclusion diseases (NIID). polyglycine 19-30 gamma-glutamylcyclotransferase Homo sapiens 95-98 34081916-2 2021 (2021) show that a polyglycine-expanded protein, uN2CpolyG, is translated from an expansion of GGC repeats in the 5" UTR of the NOTCH2NLC (Notch homolog 2 N-terminal-like C) gene, defining a new pathological mechanism for neuronal intranuclear inclusion diseases (NIID). polyglycine 19-30 notch receptor 2 Homo sapiens 128-134 35274390-3 2022 In NIID cases with an expansion of GGC repeats in the 5"-untranslated region (5"-UTR) of the Notch 2 N-terminal like C (NOTCH2NLC) gene, these repeats are located in an upstream open reading frame (uN2C) and result in the production of a polyglycine-containing protein called uN2CpolyG. polyglycine 238-249 notch receptor 2 Homo sapiens 120-129 2917688-4 1989 Androgen receptor cDNAs from different sources contained information for poly-glycine stretches of variable size (23 and 27 residues, respectively). polyglycine 73-85 androgen receptor Homo sapiens 0-17 35328005-3 2022 Repeat Associated Non-AUG (RAN)-translation dependent on the variable CGG-repeat length is thought to cause FXPOI, due to the production of a polyglycine-containing FMR1 protein, FMRpolyG. polyglycine 142-153 RAN, member RAS oncogene family Homo sapiens 27-30 35328005-3 2022 Repeat Associated Non-AUG (RAN)-translation dependent on the variable CGG-repeat length is thought to cause FXPOI, due to the production of a polyglycine-containing FMR1 protein, FMRpolyG. polyglycine 142-153 fragile X messenger ribonucleoprotein 1 Homo sapiens 165-169 3251571-0 1988 Conformational properties of a polyglycine chain with secondary and tertiary structures of lysozyme. polyglycine 31-42 lysozyme Homo sapiens 91-99 3293085-1 1988 Polyglycine, polyalanine, polyleucine, poly-alpha-glutamic acid, poly-gamma-glutamic acid and poly-alpha-lysine were complexed with insulin under non denaturating conditions. polyglycine 0-11 insulin Homo sapiens 132-139 3110602-3 1987 Novel structural features of the Dsrc28C protein include a basic pI and a polyglycine domain near the amino terminus. polyglycine 74-85 Btk family kinase at 29A Drosophila melanogaster 33-40