PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33993366-0	2022	Imaging features of gadoxetic acid-enhanced MR imaging for evaluation of tumor-infiltrating CD8 cells and PD-L1 expression in hepatocellular carcinoma.	gadolinium ethoxybenzyl DTPA	20-34	CD8a molecule	Homo sapiens	92-95
33993366-0	2022	Imaging features of gadoxetic acid-enhanced MR imaging for evaluation of tumor-infiltrating CD8 cells and PD-L1 expression in hepatocellular carcinoma.	gadolinium ethoxybenzyl DTPA	20-34	CD274 molecule	Homo sapiens	106-111
33993366-2	2022	We aimed to determine the ability of preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings to predict CD8 cell density and PD-L1 expression in HCC.	gadolinium ethoxybenzyl DTPA	50-64	CD8a molecule	Homo sapiens	127-130
33993366-2	2022	We aimed to determine the ability of preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings to predict CD8 cell density and PD-L1 expression in HCC.	gadolinium ethoxybenzyl DTPA	50-64	CD274 molecule	Homo sapiens	148-153
32556463-1	2020	OBJECTIVES: To reveal the utility of motion artifact reduction with convolutional neural network (MARC) in gadoxetate disodium-enhanced multi-arterial phase MRI of the liver.	gadolinium ethoxybenzyl DTPA	107-126	C-C motif chemokine ligand 7	Homo sapiens	98-102
33084108-0	2021	Unusual Distribution Kinetics of Gadoxetate in Healthy Human Subjects Genotyped for OATP1B1: Application of Population Analysis and a Minimal Physiological-Based Pharmacokinetic Model.	gadolinium ethoxybenzyl DTPA	33-43	solute carrier organic anion transporter family member 1B1	Homo sapiens	84-91
33084108-6	2021	In elucidating the impact of OATP1B1 genotype (*1a/*1a and *15/*15) on the pharmacokinetics of gadoxetate, we found that tissue uptake and back-transfer rates were significantly reduced, whereas the hepatic sinusoidal efflux rate was significantly increased in carriers of the *15/*15 haplotype compared with those of the *1a/*1a (wild type).	gadolinium ethoxybenzyl DTPA	95-105	solute carrier organic anion transporter family member 1B1	Homo sapiens	29-36
33707581-2	2021	Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers.	gadolinium ethoxybenzyl DTPA	0-19	solute carrier organic anion transporter family member 1B3	Homo sapiens	38-45
33707581-2	2021	Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers.	gadolinium ethoxybenzyl DTPA	0-19	solute carrier organic anion transporter family member 1B3	Homo sapiens	95-102
33603462-0	2021	OATP1B3 Expression in Hepatocellular Carcinoma Correlates with Intralesional Gd-EOB-DTPA Uptake and Signal Intensity on Gd-EOB-DTPA-Enhanced MRI.	gadolinium ethoxybenzyl DTPA	77-88	solute carrier organic anion transporter family member 1B3	Homo sapiens	0-7
33603462-1	2021	Background: To evaluate the predictive value of the OATP1B3 expression in hepatocellular carcinoma (HCC) for the gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) uptake and the signal intensity (SI) in the hepatobiliary (HB) phase.	gadolinium ethoxybenzyl DTPA	113-171	solute carrier organic anion transporter family member 1B3	Homo sapiens	52-59
33603462-1	2021	Background: To evaluate the predictive value of the OATP1B3 expression in hepatocellular carcinoma (HCC) for the gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) uptake and the signal intensity (SI) in the hepatobiliary (HB) phase.	gadolinium ethoxybenzyl DTPA	173-184	solute carrier organic anion transporter family member 1B3	Homo sapiens	52-59
33603462-9	2021	Conclusion: The OATP1B3 expression in HCC can predict the uptake of Gd-EOB-DTPA and the SI of the HB phase.	gadolinium ethoxybenzyl DTPA	68-79	solute carrier organic anion transporter family member 1B3	Homo sapiens	16-23
32836213-9	2020	CONCLUSION: LR-3 and LR-4 without APHE were often downgraded or remained stable in category on Gd-EOB-DTPA-enhanced MRI follow-up.	gadolinium ethoxybenzyl DTPA	95-106	LDL receptor related protein 5	Homo sapiens	12-16
33883364-1	2021	PURPOSE: To evaluate the utility of T2-enhanced spin-echo imaging using the time-reversed gradient echo sequence (T2FFE imaging) in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for differentiating hemangiomas from metastatic tumors.	gadolinium ethoxybenzyl DTPA	165-179	spindlin 1	Homo sapiens	48-52
32556463-11	2020	CONCLUSIONS: Motion artifacts and lesion conspicuity of gadoxetate disodium-enhanced arterial phase liver MRI were significantly improved by the MARC filter, especially in cases with substantial artifacts.	gadolinium ethoxybenzyl DTPA	56-66	C-C motif chemokine ligand 7	Homo sapiens	145-149
32556463-14	2020	MARC significantly improved MR image quality after gadoxetate disodium administration by reducing motion artifacts, especially in cases with severely degraded images.	gadolinium ethoxybenzyl DTPA	51-70	C-C motif chemokine ligand 7	Homo sapiens	0-4
32458127-6	2020	Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes.	gadolinium ethoxybenzyl DTPA	161-175	solute carrier organic anion transporter family member 1B3	Homo sapiens	52-101
32458127-6	2020	Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes.	gadolinium ethoxybenzyl DTPA	161-175	solute carrier organic anion transporter family member 1B1	Homo sapiens	106-117
32333148-1	2020	OBJECTIVES: To compare diagnostic performances of current guidelines for the diagnosis of HCC in LT candidates using gadoxetic acid-enhanced liver MRI (Gd-EOB-MRI).	gadolinium ethoxybenzyl DTPA	117-131	cell cycle regulator of NHEJ	Homo sapiens	152-162
32468212-1	2020	PURPOSE: To identify gadoxetate disodium-enhanced MRI features distinguishing hepatic IPT from CLM.	gadolinium ethoxybenzyl DTPA	21-40	tRNA isopentenyltransferase 1	Homo sapiens	86-89
33083276-0	2020	Gd-EOB-DTPA-MRI Could Predict WNT/beta-Catenin Mutation and Resistance to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma.	gadolinium ethoxybenzyl DTPA	0-11	catenin beta 1	Homo sapiens	34-46
32468212-7	2020	CONCLUSION: Central hypointensity with a relatively peripheral hyperintensity on HBP and SIRlesion/liver on HBP and DWI may be reliable gadoxetate disodium-enhanced MRI features for distinguishing IPT from CLM.	gadolinium ethoxybenzyl DTPA	136-146	tRNA isopentenyltransferase 1	Homo sapiens	197-200
32410411-11	2020	CONCLUSION: The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI.	gadolinium ethoxybenzyl DTPA	137-151	solute carrier organic anion transporter family member 1B3	Homo sapiens	33-40
32166493-14	2020	CONCLUSION: Noncontrast and abbreviated MRI using gadoxetic acid showed comparable diagnostic performance for detecting patients with HCCs in the early stage.	gadolinium ethoxybenzyl DTPA	50-64	holocytochrome c synthase	Homo sapiens	134-138
32166493-15	2020	KEY POINTS:   Diagnostic performance of noncontrast MRI and abbreviated MRI using gadoxetic acid for detecting HCCs is comparable in patients with HCCs in the early stage.	gadolinium ethoxybenzyl DTPA	82-96	holocytochrome c synthase	Homo sapiens	111-115
32033745-9	2020	CONCLUSION: A considerable proportion of HCCs could have been categorised as LR-M as they had a targetoid appearance on gadoxetic acid-enhanced MRI.	gadolinium ethoxybenzyl DTPA	120-134	holocytochrome c synthase	Homo sapiens	41-45
32064560-3	2020	Gadoxetic acid-enhanced MRI, an indirect molecular imaging method, reflects OATP1B3 expression in HCC.	gadolinium ethoxybenzyl DTPA	0-14	solute carrier organic anion transporter family member 1B3	Homo sapiens	76-83
32410411-11	2020	CONCLUSION: The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI.	gadolinium ethoxybenzyl DTPA	137-151	solute carrier organic anion transporter family member 1B3	Homo sapiens	106-113
31834849-5	2020	The tumor cells of some types of hepatocellular adenoma (eg, beta-catenin-activated type, inflammatory type) and hepatocellular carcinoma (eg, green hepatoma) can show uptake of gadoxetic acid.	gadolinium ethoxybenzyl DTPA	178-192	catenin beta 1	Homo sapiens	61-73
31939096-3	2020	The preoperative Gd-EOB-DTPA MRI showed a 2.7-cm HCC located in segment VIII.	gadolinium ethoxybenzyl DTPA	17-28	cytochrome c oxidase subunit 8A	Homo sapiens	72-76
31917760-1	2020	OBJECTIVES: The aim of this study was to develop a method to determine hepatic and renal clearance of the 2 diastereoisomers (Gd-A, Gd-B) of Gd-EOB-DTPA separately.	gadolinium ethoxybenzyl DTPA	141-152	guanine deaminase	Homo sapiens	126-130
32002645-0	2020	A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI.	gadolinium ethoxybenzyl DTPA	87-101	keratin 19	Homo sapiens	32-46
32002645-10	2020	CONCLUSIONS: The combined model based on a fusion radiomics signature derived from arterial and hepatobiliary phase images of gadoxetic acid-enhanced MRI can be a reliable biomarker for CK19 status of HCC.	gadolinium ethoxybenzyl DTPA	126-140	keratin 19	Homo sapiens	186-190
32002645-11	2020	KEY POINTS:   Arterial rim enhancement pattern and irregular tumor margin on hepatobiliary phase on gadoxetic acid-enhanced MRI can be useful for evaluating CK19 status of HCC.	gadolinium ethoxybenzyl DTPA	100-114	keratin 19	Homo sapiens	157-161
30487262-4	2019	OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA).	gadolinium ethoxybenzyl DTPA	135-154	solute carrier organic anion transporter family, member 1a1	Mus musculus	0-7
31210715-2	2019	Current state-of-the-art magnetic resonance imaging (MRI) using gadoxetic acid provides many imaging features that could potentially be used to classify single HCC as pT1 or pT2.	gadolinium ethoxybenzyl DTPA	64-78	zinc finger protein 77	Homo sapiens	167-170
31210715-3	2019	AIM: To determine which gadoxetic acid-enhanced MRI (EOB-MRI) findings predict pathologic stage T2 in patients with solitary HCC (cT1).	gadolinium ethoxybenzyl DTPA	24-38	cardiotrophin 1	Homo sapiens	130-133
30672844-5	2019	Oatp1a1 operates by transporting gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) into cells, and it concomitantly improves BLI substrate uptake.	gadolinium ethoxybenzyl DTPA	94-105	solute carrier organic anion transporter family, member 1a1	Mus musculus	0-7
30672844-8	2019	On MRI, post-Gd-EOB-DTPA T1-weighted images of Oatp1a1-expressing tumors exhibited significantly increased contrast-to-noise ratios compared with control tumors and precontrast images (P < 0.05).	gadolinium ethoxybenzyl DTPA	13-24	solute carrier organic anion transporter family, member 1a1	Mus musculus	47-54
30465867-9	2019	DCE-MRI with Gd-EOB-DTPA showed that Tmax and T1/2 were significantly longer in MC4R-KO mice fed an HFD compared with wild type (WT) mice (Tmax, WT, 3.9 +- 0.4 min; MC4R-KO, 7.4 +- 1.5 min; T1/2, WT, 23.7 +- 1.9 min; MC4R-KO, 62.5 +- 18.5 min).	gadolinium ethoxybenzyl DTPA	13-24	melanocortin 4 receptor	Mus musculus	80-84
30465867-12	2019	The liver kinetics of Gd-EOB-DTPA were significantly different in MC4R-KO mice fed an HFD from WT mice, and correlated with the histopathologic score.	gadolinium ethoxybenzyl DTPA	22-33	melanocortin 4 receptor	Mus musculus	66-70
31400382-6	2019	Additionally, PET imaging with the integrin alpha6 targeted 18F-RWY enabled to visualize small HCC lesions with diameters approximately 0.2 cm that was hard to be distinguished from surround hepatic vascular by enhanced MRI with Gd-EOB-DTPA.	gadolinium ethoxybenzyl DTPA	229-240	integrin alpha 6	Mus musculus	35-50
31179770-6	2021	The inhibitory activities of gadoteric acid, gadopentetic acid, gadoxetate disodium, and gadodiamide were investigated on PON1 activity of the enzyme.	gadolinium ethoxybenzyl DTPA	64-83	paraoxonase 1	Homo sapiens	122-126
31179770-10	2021	In addition, the molecular docking analyses of gadoxetate disodium and gadodiamide were carried out to understand the binding interactions on the active site of the PON1 enzyme.	gadolinium ethoxybenzyl DTPA	47-66	paraoxonase 1	Homo sapiens	165-169
30487262-4	2019	OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA).	gadolinium ethoxybenzyl DTPA	135-154	solute carrier organic anion transporter family, member 1b2	Mus musculus	12-19
30487262-4	2019	OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA).	gadolinium ethoxybenzyl DTPA	156-167	solute carrier organic anion transporter family, member 1a1	Mus musculus	0-7
30487262-4	2019	OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA).	gadolinium ethoxybenzyl DTPA	156-167	solute carrier organic anion transporter family, member 1b2	Mus musculus	12-19
29651770-10	2018	Thus, gadoxetate disodium inhibited the ATP-binding cassette sub-family C member 2 transporter.	gadolinium ethoxybenzyl DTPA	6-25	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	40-82
30218633-0	2019	OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.	gadolinium ethoxybenzyl DTPA	65-76	ATP binding cassette subfamily C member 3	Homo sapiens	14-18
30218633-11	2019	CONCLUSIONS: OATPB1/B3 and MRP3 IHC and signal intensity on HBP Gd-EOB-DTPA-enhanced MRI can help to stratify HCA according to their risk of malignant transformation.	gadolinium ethoxybenzyl DTPA	64-75	ATP binding cassette subfamily C member 3	Homo sapiens	27-31
29695578-0	2018	cDNA Microarray Analysis and Influx Transporter OATP1B1 in Liver Cells After Exposure to Gadoxetate Disodium, a Gadolinium-based Contrast Agent in MRI Liver Imaging.	gadolinium ethoxybenzyl DTPA	89-108	solute carrier organic anion transporter family member 1B1	Homo sapiens	48-55
29695578-9	2018	The SLCO1C1 (solute carrier organic anion transporter family member 1C1) mRNA expression was also increased by 2.62-fold (p-value=0.0006) in gadoxetate disodium-treated cells.	gadolinium ethoxybenzyl DTPA	141-160	solute carrier organic anion transporter family member 1C1	Homo sapiens	4-11
29695578-9	2018	The SLCO1C1 (solute carrier organic anion transporter family member 1C1) mRNA expression was also increased by 2.62-fold (p-value=0.0006) in gadoxetate disodium-treated cells.	gadolinium ethoxybenzyl DTPA	141-160	solute carrier organic anion transporter family member 1C1	Homo sapiens	13-71
29695578-10	2018	Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression.	gadolinium ethoxybenzyl DTPA	44-54	solute carrier organic anion transporter family member 1B1	Homo sapiens	77-118
29695578-10	2018	Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression.	gadolinium ethoxybenzyl DTPA	44-54	solute carrier organic anion transporter family member 1B1	Homo sapiens	120-127
29695578-10	2018	Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression.	gadolinium ethoxybenzyl DTPA	44-54	solute carrier organic anion transporter family member 1A2	Homo sapiens	120-124
29695578-10	2018	Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression.	gadolinium ethoxybenzyl DTPA	44-54	solute carrier organic anion transporter family member 1C1	Homo sapiens	186-193
29166246-12	2018	Conclusion At gadoxetic acid-enhanced and diffusion-weighted MR imaging, irregular margin, arterial phase rim enhancement, lower tumor-to-liver ADC ratio, and lower tumor-to-liver SI ratio at HBP imaging may be helpful to predict CK19-positive HCC with early recurrence (<2 years) after curative resection.	gadolinium ethoxybenzyl DTPA	14-28	keratin 19	Homo sapiens	230-234
29709031-0	2018	Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin.	gadolinium ethoxybenzyl DTPA	0-14	solute carrier organic anion transporter family member 1B1	Homo sapiens	169-217
29709031-0	2018	Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin.	gadolinium ethoxybenzyl DTPA	0-14	solute carrier organic anion transporter family member 1B3	Homo sapiens	222-229
29709031-2	2018	Gadoxetic acid is also transported by OATP1B1/1B3.	gadolinium ethoxybenzyl DTPA	0-14	solute carrier organic anion transporter family member 1B1	Homo sapiens	38-49
29166246-0	2018	Imaging Features of Gadoxetic Acid-enhanced and Diffusion-weighted MR Imaging for Identifying Cytokeratin 19-positive Hepatocellular Carcinoma: A Retrospective Observational Study.	gadolinium ethoxybenzyl DTPA	20-34	keratin 19	Homo sapiens	94-108
28488786-6	2018	RESULTS: Enhancement ratio on gadoxetic acid-enhanced MRI in HCC with beta-catenin/GS (+) HNF4alpha (+) was significantly higher than those of the other three groups (P < 0.001).	gadolinium ethoxybenzyl DTPA	30-44	catenin beta 1	Homo sapiens	70-82
28488786-6	2018	RESULTS: Enhancement ratio on gadoxetic acid-enhanced MRI in HCC with beta-catenin/GS (+) HNF4alpha (+) was significantly higher than those of the other three groups (P < 0.001).	gadolinium ethoxybenzyl DTPA	30-44	hepatocyte nuclear factor 4 alpha	Homo sapiens	90-99
28488786-0	2018	Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of beta-catenin and hepatocyte nuclear factor 4alpha in hepatocellular carcinoma.	gadolinium ethoxybenzyl DTPA	0-14	catenin beta 1	Homo sapiens	77-89
28488786-1	2018	AIM: The aim of this study is to clarify the correlation of the co-activation of beta-catenin and hepatocyte nuclear factor (HNF)4alpha with the findings of gadoxetic acid-enhanced magnetic resonance imaging (MRI), organic anion transporting polypeptide (OATP)1B3 expression, and histological findings in hepatocellular carcinoma (HCC).	gadolinium ethoxybenzyl DTPA	157-171	catenin beta 1	Homo sapiens	81-93
28488786-10	2018	CONCLUSION: Co-activation of beta-catenin and HNF4alpha would promote OATP1B3 expression, and consequently higher enhancement ratio on gadoxetic acid-enhanced MRI and higher differentiation grade in HCC.	gadolinium ethoxybenzyl DTPA	135-149	catenin beta 1	Homo sapiens	29-41
28488786-10	2018	CONCLUSION: Co-activation of beta-catenin and HNF4alpha would promote OATP1B3 expression, and consequently higher enhancement ratio on gadoxetic acid-enhanced MRI and higher differentiation grade in HCC.	gadolinium ethoxybenzyl DTPA	135-149	hepatocyte nuclear factor 4 alpha	Homo sapiens	46-55
29391764-1	2018	AIM: To optimize the hepatobiliary phase delay time (HBP-DT) of Gd-EOB-DTPA-enhanced magnetic resonance imaging (GED-MRI) for more efficient identification of hepatocellular carcinoma (HCC) occurring in different degrees of cirrhosis assessed by Child-Pugh (CP) score.	gadolinium ethoxybenzyl DTPA	64-75	heme binding protein 1	Homo sapiens	53-56
29254310-1	2017	The aim of this study was to investigate the value of Gd-EOB-DTPA-enhanced MRI on hepatobiliary phase (HBP) imaging and T1 mapping sequence in the differentiation of hepatocellular carcinoma (HCC).	gadolinium ethoxybenzyl DTPA	54-65	heme binding protein 1	Homo sapiens	103-106
28444420-6	2017	CONCLUSIONS: Fat-suppressed T2-weighted MR imaging with 3D-VISTA acquired after the hepatobiliary phase on Gd-EOB-DTPA-enhanced imaging may be a useful noninvasive method for evaluating the periportal lymphatic system and the degree of hepatic fibrosis.	gadolinium ethoxybenzyl DTPA	107-118	V-set immunoregulatory receptor	Homo sapiens	59-64
29254310-16	2017	T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC.	gadolinium ethoxybenzyl DTPA	38-49	CD5 molecule	Homo sapiens	0-2
29254310-16	2017	T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC.	gadolinium ethoxybenzyl DTPA	38-49	heme binding protein 1	Homo sapiens	31-34
29254310-16	2017	T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC.	gadolinium ethoxybenzyl DTPA	38-49	heme binding protein 1	Homo sapiens	97-100
29254310-16	2017	T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC.	gadolinium ethoxybenzyl DTPA	104-115	CD5 molecule	Homo sapiens	0-2
29254310-16	2017	T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC.	gadolinium ethoxybenzyl DTPA	104-115	heme binding protein 1	Homo sapiens	97-100
27195437-13	2016	PT activity of at least 86.9% could be used to shorten examination times at Gd-EOB-DTPA-enhanced MR imaging.	gadolinium ethoxybenzyl DTPA	76-87	coagulation factor II, thrombin	Homo sapiens	0-2
28609188-1	2017	OBJECTIVE: The purpose of this study is to evaluate the effect of subtraction images of gadoxetic acid-enhanced MRI on the image interpretation of focal hepatic lesions in patients at risk for hepatocellular carcinoma (HCC).	gadolinium ethoxybenzyl DTPA	88-102	HCC	Homo sapiens	219-222
28709718-10	2017	CONCLUSION: View-sharing mHAP was feasible without compromising image quality and contributed to the improvement in diagnostic confidence for hypervascular HCC in gadoxetic acid-enhance MR imaging.	gadolinium ethoxybenzyl DTPA	163-177	retinoic acid receptor, beta	Mus musculus	25-29
29050339-0	2017	Aberrant expression of OATP1B3 in colorectal cancer liver metastases and its clinical implication on gadoxetic acid-enhanced MRI.	gadolinium ethoxybenzyl DTPA	101-115	solute carrier organic anion transporter family member 1B3	Homo sapiens	23-30
27957635-7	2017	CONCLUSION: Although enhancement patterns of recurrent HCC in transplanted liver did not affect OS and TTR, these HCCs that arise after LT frequently revealed atypical enhancement on gadoxetic acid-enhanced MR imaging.	gadolinium ethoxybenzyl DTPA	183-197	holocytochrome c synthase	Homo sapiens	114-118
27957635-8	2017	KEY POINTS:   Recurrent HCCs after LT showed atypical enhancement on gadoxetic acid-enhanced MRI.	gadolinium ethoxybenzyl DTPA	69-83	holocytochrome c synthase	Homo sapiens	24-28
28624009-11	2017	CONCLUSION: T1 relaxation time at post-contrast of Gd-EOB-DTPA (T1hb) was strongly correlated with ICG clearance and moderately correlated HH15 with 99mTc-GSA.	gadolinium ethoxybenzyl DTPA	51-62	GNAS complex locus	Homo sapiens	155-158
27780379-2	2017	We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI).	gadolinium ethoxybenzyl DTPA	115-129	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	65-70
27780379-2	2017	We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI).	gadolinium ethoxybenzyl DTPA	115-129	ATP binding cassette subfamily C member 2	Rattus norvegicus	75-79
28266528-2	2017	Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function.	gadolinium ethoxybenzyl DTPA	135-146	solute carrier organic anion transporter family member 1B1	Homo sapiens	11-18
26187715-0	2015	Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome.	gadolinium ethoxybenzyl DTPA	20-31	solute carrier organic anion transporter family member 1B3	Homo sapiens	65-72
26693795-2	2016	Gadoxetate demonstrates unique pharmacokinetic and pharmacodynamic properties, because its uptake in hepatocytes occurs via the organic anion transporting polypeptide (OATP) transporter expressed at the sinusoidal membrane, and its biliary excretion via the multidrug resistance-associated proteins (MRPs) at the canalicular membrane.	gadolinium ethoxybenzyl DTPA	0-10	solute carrier organic anion transporter family member 1A2	Homo sapiens	128-166
26693795-2	2016	Gadoxetate demonstrates unique pharmacokinetic and pharmacodynamic properties, because its uptake in hepatocytes occurs via the organic anion transporting polypeptide (OATP) transporter expressed at the sinusoidal membrane, and its biliary excretion via the multidrug resistance-associated proteins (MRPs) at the canalicular membrane.	gadolinium ethoxybenzyl DTPA	0-10	solute carrier organic anion transporter family member 1A2	Homo sapiens	168-172
26205638-6	2016	RESULTS: Significant changes of T1 relaxation times between non-enhanced and gadoxetate disodium-enhanced MRI at HP1 and HP2 could be observed in all liver segments (p < 0.0001).	gadolinium ethoxybenzyl DTPA	77-96	chromobox 5	Homo sapiens	113-116
26130441-10	2016	CONCLUSIONS: The sensitivity for preoperative detection of HCCs was higher for gadoxetic acid-enhanced MRI than for multiphasic MDCT imaging.	gadolinium ethoxybenzyl DTPA	79-93	holocytochrome c synthase	Homo sapiens	59-63
25560223-2	2015	Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC.	gadolinium ethoxybenzyl DTPA	81-140	solute carrier organic anion transporter family member 1B3	Homo sapiens	0-37
25560223-2	2015	Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC.	gadolinium ethoxybenzyl DTPA	81-140	solute carrier organic anion transporter family member 1B3	Homo sapiens	39-46
25560223-2	2015	Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC.	gadolinium ethoxybenzyl DTPA	142-153	solute carrier organic anion transporter family member 1B3	Homo sapiens	0-37
25560223-2	2015	Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC.	gadolinium ethoxybenzyl DTPA	142-153	solute carrier organic anion transporter family member 1B3	Homo sapiens	39-46
25668519-11	2015	CONCLUSION: HCCs with beta-catenin mutation showed a higher grade of differentiation with frequent pseudoglandular patterns and bile production, and characteristic imaging findings included a high enhancement ratio at gadoxetic acid-enhanced MR imaging and a high apparent diffusion coefficient at diffusion-weighted imaging.	gadolinium ethoxybenzyl DTPA	218-232	holocytochrome c synthase	Homo sapiens	12-16
25820755-9	2015	CONCLUSIONS: A simultaneous PET/MRI using both (68)Ga-DOTA-TOC and gadoxetate disodium was successful in whole body staging of patients with neuroendocrine tumor.	gadolinium ethoxybenzyl DTPA	67-86	cell cycle regulator of NHEJ	Homo sapiens	28-35
26076199-14	2015	CONCLUSION: Ktrans and iAUC obtained from DCE-MRI with Gd-EOB-DTPA are useful for the detection and staging of rat liver fibrosis induced by CCl4.	gadolinium ethoxybenzyl DTPA	55-66	C-C motif chemokine ligand 4	Rattus norvegicus	141-145
25985059-11	2015	The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP.	gadolinium ethoxybenzyl DTPA	74-88	solute carrier organic anion transporter family member 1B1	Homo sapiens	14-21
25985059-11	2015	The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP.	gadolinium ethoxybenzyl DTPA	74-88	ATP binding cassette subfamily C member 3	Homo sapiens	28-32
26076199-1	2015	PURPOSE: To investigate the utility of dynamic contrast-enhanced MRI (DCE-MRI) with Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for detecting liver fibrosis induced by carbon tetrachloride (CCl4) in rats.	gadolinium ethoxybenzyl DTPA	84-143	C-C motif chemokine ligand 4	Rattus norvegicus	220-224
25668519-11	2015	CONCLUSION: HCCs with beta-catenin mutation showed a higher grade of differentiation with frequent pseudoglandular patterns and bile production, and characteristic imaging findings included a high enhancement ratio at gadoxetic acid-enhanced MR imaging and a high apparent diffusion coefficient at diffusion-weighted imaging.	gadolinium ethoxybenzyl DTPA	218-232	catenin beta 1	Homo sapiens	22-34
25289480-1	2015	PURPOSE: To compare the value of enhancement and pharmacokinetic parameters measured at dynamic gadoxetate-enhanced magnetic resonance (MR) imaging in determining hepatic organic anion transporter expression in control rats and rats with advanced liver fibrosis.	gadolinium ethoxybenzyl DTPA	96-106	ATP binding cassette subfamily C member 3	Rattus norvegicus	171-196
25231411-11	2015	CONCLUSIONS: Although AMLs showed similar enhancement patterns to HCCs during the dynamic phases of gadoxetic acid-enhanced MRI, using characteristic MR features of AML during the HBP and demographic differences, one can better differentiate AML from HCC.	gadolinium ethoxybenzyl DTPA	100-114	holocytochrome c synthase	Homo sapiens	66-70
25289480-10	2015	CONCLUSION: The pharmacokinetic parameter HEF at dynamic gadoxetate-enhanced MR imaging is independently correlated with hepatic organic anion transporter expression.	gadolinium ethoxybenzyl DTPA	57-67	ATP binding cassette subfamily C member 3	Rattus norvegicus	129-154
24700365-2	2014	Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions with regard to vascularity and the activity of the organic anion transporter OATP1B3.	gadolinium ethoxybenzyl DTPA	0-59	solute carrier organic anion transporter family member 1B3	Homo sapiens	250-257
25203131-0	2015	Diagnostic performance of gadoxetic acid-enhanced liver MR imaging in the detection of HCCs and allocation of transplant recipients on the basis of the Milan criteria and UNOS guidelines: correlation with histopathologic findings.	gadolinium ethoxybenzyl DTPA	26-40	holocytochrome c synthase	Homo sapiens	87-91
25262955-1	2014	RATIONALE AND OBJECTIVES: To determine the accuracy of magnetic resonance imaging (MRI) with gadoxetic acid disodium for the detection of hepatocellular carcinoma (HCC).	gadolinium ethoxybenzyl DTPA	93-116	HCC	Homo sapiens	164-167
25262955-11	2014	CONCLUSIONS: MRI with gadoxetic acid disodium is a noninvasive and no radiation exposure imaging modality with high sensitivity and specificity for the detection of HCC.	gadolinium ethoxybenzyl DTPA	22-45	HCC	Homo sapiens	165-168
24700365-2	2014	Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions with regard to vascularity and the activity of the organic anion transporter OATP1B3.	gadolinium ethoxybenzyl DTPA	61-72	solute carrier organic anion transporter family member 1B3	Homo sapiens	250-257
24700365-6	2014	By contrast, HCC showing reduced Gd-EOB-DTPA uptake with high serum AFP levels was associated with poor prognosis and the activation of the oncogene FOXM1.	gadolinium ethoxybenzyl DTPA	33-44	alpha fetoprotein	Homo sapiens	68-71
24700365-6	2014	By contrast, HCC showing reduced Gd-EOB-DTPA uptake with high serum AFP levels was associated with poor prognosis and the activation of the oncogene FOXM1.	gadolinium ethoxybenzyl DTPA	33-44	forkhead box M1	Homo sapiens	149-154
24700365-7	2014	Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo.	gadolinium ethoxybenzyl DTPA	40-51	hepatocyte nuclear factor 4 alpha	Homo sapiens	13-18
24700365-7	2014	Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo.	gadolinium ethoxybenzyl DTPA	40-51	alpha fetoprotein	Homo sapiens	99-102
24700365-7	2014	Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo.	gadolinium ethoxybenzyl DTPA	40-51	forkhead box M1	Homo sapiens	107-112
24700365-7	2014	Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo.	gadolinium ethoxybenzyl DTPA	222-233	hepatocyte nuclear factor 4 alpha	Homo sapiens	13-18
24946283-0	2014	OATP1B3 expression is strongly associated with Wnt/beta-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma.	gadolinium ethoxybenzyl DTPA	109-123	solute carrier organic anion transporter family member 1B3	Homo sapiens	0-7
24666574-13	2014	CONCLUSIONS: Gd-EOB-DTPA-enhanced MRI described RLI as a decreased uptake of Gd-EOB-DTPA matching the irradiated area.	gadolinium ethoxybenzyl DTPA	13-24	ATP binding cassette subfamily E member 1	Homo sapiens	48-51
24666574-13	2014	CONCLUSIONS: Gd-EOB-DTPA-enhanced MRI described RLI as a decreased uptake of Gd-EOB-DTPA matching the irradiated area.	gadolinium ethoxybenzyl DTPA	77-88	ATP binding cassette subfamily E member 1	Homo sapiens	48-51
23903870-4	2014	Uptakes of Sonazoid and Gd-EOB-DTPA were assessed by Sonazoid enhancement index and EOB enhancement ratio in relation to immunohistochemistry of CD68 and organic anion transporting polypeptide 8 (OATP8), respectively.	gadolinium ethoxybenzyl DTPA	24-35	solute carrier organic anion transporter family member 1B3	Homo sapiens	154-194
22391331-8	2012	The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1.	gadolinium ethoxybenzyl DTPA	57-67	solute carrier organic anion transporter family member 1B1	Homo sapiens	98-105
24289722-7	2013	RESULTS: Diagnostic accuracy was significantly improved by the addition of Gd-EOB-DTPA-enhanced dynamic images: Az in set 1 was 0.708 and 0.833 in set 2 (P = 0.0002).	gadolinium ethoxybenzyl DTPA	75-86	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	118-123
24289722-7	2013	RESULTS: Diagnostic accuracy was significantly improved by the addition of Gd-EOB-DTPA-enhanced dynamic images: Az in set 1 was 0.708 and 0.833 in set 2 (P = 0.0002).	gadolinium ethoxybenzyl DTPA	75-86	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	147-152
24114823-1	2013	INTRODUCTION: Gadoxetate-disodium is a liver-specific MR contrast agent absorbed by hepatocytes via organic anion transporting polypeptide 1B3 and is excreted into the biliary system by multidrug resistance-associated protein 2.	gadolinium ethoxybenzyl DTPA	14-33	ATP binding cassette subfamily C member 2	Homo sapiens	186-227
23884757-2	2013	AIM: We performed a meta-analysis of all available studies of the diagnostic performance of gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for detection of HCC in patients with chronic liver disease.	gadolinium ethoxybenzyl DTPA	92-106	cell cycle regulator of NHEJ	Homo sapiens	121-131
23442774-0	2013	Dynamic contrast-enhanced MRI of the liver in Mrp2-deficient rats using the hepatobiliary contrast agent Gd-EOB-DTPA.	gadolinium ethoxybenzyl DTPA	105-116	ATP binding cassette subfamily C member 2	Rattus norvegicus	46-50
23442774-8	2013	RESULTS: The relative enhancement of the Mrp2-deficient, Eisai hyperbilirubinuria rats (EHBRs) (48.6% [3.4%]) was significantly lower than that of the control rats (64.0% [3.2%]; P < 0.001) 5 minutes after the Gd-EOB-DTPA injection.	gadolinium ethoxybenzyl DTPA	213-224	ATP binding cassette subfamily C member 2	Rattus norvegicus	41-45
22847903-1	2012	BACKGROUND: As gadoxetic acid-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) have been widely used for the evaluation of hepatocellular carcinoma (HCC), it is clinically relevant to determine the diagnostic efficacy of gadoxetic acid-enhanced MRI and DWI for detection of HCCs with respect to the severity of liver cirrhosis.	gadolinium ethoxybenzyl DTPA	15-29	holocytochrome c synthase	Homo sapiens	304-308
22847903-2	2012	PURPOSE: To compare the diagnostic accuracy and sensitivity of gadoxetic acid-enhanced MRI and DWI for detection of HCCs with respect to the severity of liver cirrhosis.	gadolinium ethoxybenzyl DTPA	63-77	holocytochrome c synthase	Homo sapiens	116-120
22504332-3	2012	The hepatocyte uptake of Gd-EOB-DTPA mainly occurs via the organic anion transporter polypeptides OATP1B1 and B3 located at the sinusoidal membrane and biliary excretion via the multidrug resistance-associated proteins MRP2 at the canalicular membrane.	gadolinium ethoxybenzyl DTPA	25-36	solute carrier organic anion transporter family member 1B1	Homo sapiens	98-105
22504332-3	2012	The hepatocyte uptake of Gd-EOB-DTPA mainly occurs via the organic anion transporter polypeptides OATP1B1 and B3 located at the sinusoidal membrane and biliary excretion via the multidrug resistance-associated proteins MRP2 at the canalicular membrane.	gadolinium ethoxybenzyl DTPA	25-36	ATP binding cassette subfamily C member 2	Homo sapiens	219-223
24297598-1	2014	PURPOSE: The aim of our study was to evaluate the diagnostic accuracy of gadoxetic acid-enhanced magnetic resonance (MR) imaging both in the detection of hepatocellular carcinoma (HCC) and precancerous lesions and in the assessment of their evolution.	gadolinium ethoxybenzyl DTPA	73-87	HCC	Homo sapiens	180-183
24297598-10	2014	CONCLUSIONS: Gadoxetic acid-enhanced MR imaging is useful for detecting HCC as well as hypovascular nodules with potential progression to HCC.	gadolinium ethoxybenzyl DTPA	13-27	HCC	Homo sapiens	72-75
24297598-10	2014	CONCLUSIONS: Gadoxetic acid-enhanced MR imaging is useful for detecting HCC as well as hypovascular nodules with potential progression to HCC.	gadolinium ethoxybenzyl DTPA	13-27	HCC	Homo sapiens	138-141
24806238-1	2014	We report three cases of resected hepatocellular carcinomas with nodules showing different signal intensities in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MRI (EOB-MRI).	gadolinium ethoxybenzyl DTPA	140-199	cell cycle regulator of NHEJ	Homo sapiens	214-221
24380639-0	2014	Gd-EOB-DTPA enhanced MRI of the liver: correlation of relative hepatic enhancement, relative renal enhancement, and liver to kidneys enhancement ratio with serum hepatic enzyme levels and eGFR.	gadolinium ethoxybenzyl DTPA	0-11	epidermal growth factor receptor	Homo sapiens	188-192
23401584-9	2013	CONCLUSION: HCCs can be classified into several imaging patterns on gadoxetic acid-enhanced MR images, which are associated with tumor aggressiveness and outcome.	gadolinium ethoxybenzyl DTPA	68-82	holocytochrome c synthase	Homo sapiens	12-16
22911100-1	2012	We report a male case of beta-catenin-activated hepatocellular adenoma (HCA) focusing on findings of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI) and discussing the molecular background and possible clinical significance.	gadolinium ethoxybenzyl DTPA	101-115	catenin beta 1	Homo sapiens	25-37
22771883-1	2012	PURPOSE: To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects.	gadolinium ethoxybenzyl DTPA	162-176	solute carrier organic anion transporter family member 1B1	Homo sapiens	71-120
22771883-1	2012	PURPOSE: To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects.	gadolinium ethoxybenzyl DTPA	162-176	solute carrier organic anion transporter family member 1B3	Homo sapiens	125-132
22771883-3	2012	Cellular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured by using stable transfected embryonic kidney HEK293 cells.	gadolinium ethoxybenzyl DTPA	19-33	solute carrier organic anion transporter family member 1B1	Homo sapiens	37-44
22771883-3	2012	Cellular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured by using stable transfected embryonic kidney HEK293 cells.	gadolinium ethoxybenzyl DTPA	19-33	solute carrier organic anion transporter family member 1B3	Homo sapiens	49-56
22771883-7	2012	Liver enhancement with gadoxetic acid was reduced in subjects with OATP1B1*1a/*5 compared with wild-type subjects and those with OATP1B1*1b/*1b (area under enhancement curve, 3-480 minutes in arbitrary units [au]; 20.7 au +- 6.85 vs 36.5 au +- 8.08 [P = .006] vs 34.6 au +- 8.92 [P = .026]).	gadolinium ethoxybenzyl DTPA	23-37	solute carrier organic anion transporter family member 1B1	Homo sapiens	67-74
22771883-10	2012	CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjects.	gadolinium ethoxybenzyl DTPA	71-85	solute carrier organic anion transporter family member 1B1	Homo sapiens	27-34
22771883-10	2012	CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjects.	gadolinium ethoxybenzyl DTPA	71-85	solute carrier organic anion transporter family member 1B3	Homo sapiens	39-46
22771883-11	2012	Genetic polymorphisms of OATP1B1 are signal confounders in gadoxetic acid-enhanced liver MR imaging.	gadolinium ethoxybenzyl DTPA	59-73	solute carrier organic anion transporter family member 1B1	Homo sapiens	25-32
22270142-8	2012	CONCLUSION: Contrast-enhanced ultrasound yields a significantly higher AUC value than gadoxetate disodium-enhanced MR imaging in the assessment of arterial hypervascularity of HCC and DN.	gadolinium ethoxybenzyl DTPA	86-105	HCC	Homo sapiens	176-179
22391331-8	2012	The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1.	gadolinium ethoxybenzyl DTPA	57-67	solute carrier organic anion transporter family member 1B1	Homo sapiens	361-368
21920517-1	2012	AIM: To compare the diagnostic performances of gadoxetic acid-enhanced magnetic resonance imaging (MRI) and multiphasic multidetector computed tomography (MDCT) in the detection of hepatocellular carcinoma (HCC) in patients with chronic liver disease.	gadolinium ethoxybenzyl DTPA	47-61	HCC	Homo sapiens	207-210
21920517-11	2012	CONCLUSION: Gadoxetic acid-enhanced MRI and MDCT show similar diagnostic performances for the detection of HCC in patients with chronic liver disease.	gadolinium ethoxybenzyl DTPA	12-26	HCC	Homo sapiens	107-110
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	72-86	solute carrier organic anion transporter family member 1B3	Homo sapiens	155-160
21626360-0	2011	The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging.	gadolinium ethoxybenzyl DTPA	106-120	solute carrier organic anion transporter family member 1B3	Homo sapiens	23-28
21626360-1	2011	OBJECTIVES: To clarify the changes in organic anion-transporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis.	gadolinium ethoxybenzyl DTPA	123-137	solute carrier organic anion transporter family member 1B3	Homo sapiens	80-85
21626360-8	2011	CONCLUSIONS: The immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis, which may explain the decrease in enhancement ratio on gadoxetic acid-enhanced MR imaging.	gadolinium ethoxybenzyl DTPA	175-189	solute carrier organic anion transporter family member 1B3	Homo sapiens	51-56
19545960-7	2010	Additionally, Gd-EOB-DTPA-enhanced MR may delineate mucin as a filling defect surrounding hyperintense bile.	gadolinium ethoxybenzyl DTPA	14-25	LOC100508689	Homo sapiens	52-57
20698804-11	2010	CONCLUSION: The contrast enhancement after gadoxetic acid is comparable to Gd-DTPA and appears suitable for comprehensive TNM-staging by combining high accurate liver-specific phases with efficacious vascular enhancement in the different anatomic regions.	gadolinium ethoxybenzyl DTPA	43-57	teneurin transmembrane protein 1	Homo sapiens	122-125
21928003-0	2011	Usefulness of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance cholangiography for detecting mucin retention in bile ducts: a rare intraductal papillary mucinous neoplasm of the bile duct.	gadolinium ethoxybenzyl DTPA	14-73	LOC100508689	Homo sapiens	132-137
21928003-4	2011	We describe a rare case of IPMN-B in which gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance cholangiography was useful for detecting mucin retention in the bile ducts.	gadolinium ethoxybenzyl DTPA	43-102	LOC100508689	Homo sapiens	172-177
21691816-1	2011	The organic anion transporter peptides (OATP) 1B1 and 1B3 are hepatocytic-specific transporters determinant for the uptake of the contrast media Gd-EOB-DTPA during magnetic resonance, but variably lost in hepatocellular carcinoma (HCC).	gadolinium ethoxybenzyl DTPA	145-156	solute carrier organic anion transporter family member 1B1	Homo sapiens	4-57
21606265-0	2011	Hypervascular hepatocellular carcinoma 1 cm or smaller in patients with chronic liver disease: characterization with gadoxetic acid-enhanced MRI that includes diffusion-weighted imaging.	gadolinium ethoxybenzyl DTPA	117-131	SAP domain containing ribonucleoprotein	Homo sapiens	14-40
21628934-6	2011	Immunohistochemical analysis revealed a markedly reduced expression of organic anion transporter (OATP) 1B3 in this nodule, which implied decreased Gd-EOB-DTPA uptake by hepatocytes and accounted for the low signal intensity during the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI.	gadolinium ethoxybenzyl DTPA	148-159	solute carrier organic anion transporter family member 1B3	Homo sapiens	71-107
21628934-6	2011	Immunohistochemical analysis revealed a markedly reduced expression of organic anion transporter (OATP) 1B3 in this nodule, which implied decreased Gd-EOB-DTPA uptake by hepatocytes and accounted for the low signal intensity during the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI.	gadolinium ethoxybenzyl DTPA	259-270	solute carrier organic anion transporter family member 1B3	Homo sapiens	71-107
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	72-86	ATP binding cassette subfamily C member 3	Homo sapiens	165-169
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	72-86	solute carrier organic anion transporter family member 1B3	Homo sapiens	217-222
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	72-86	ATP binding cassette subfamily C member 3	Homo sapiens	239-243
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	187-201	solute carrier organic anion transporter family member 1B3	Homo sapiens	155-160
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	187-201	ATP binding cassette subfamily C member 3	Homo sapiens	165-169
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	187-201	solute carrier organic anion transporter family member 1B3	Homo sapiens	217-222
20663969-11	2010	CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3.	gadolinium ethoxybenzyl DTPA	187-201	ATP binding cassette subfamily C member 3	Homo sapiens	239-243
20663976-12	2010	CONCLUSION: Findings showed that liver cirrhosis promotes the elimination of gadoxetic acid mediated by mrp2; therefore, mrp2 up-regulation may explain the significant signal intensity loss noted on gadoxetic acid-enhanced MR images in the rat.	gadolinium ethoxybenzyl DTPA	77-91	ATP binding cassette subfamily C member 2	Rattus norvegicus	104-108
20663976-12	2010	CONCLUSION: Findings showed that liver cirrhosis promotes the elimination of gadoxetic acid mediated by mrp2; therefore, mrp2 up-regulation may explain the significant signal intensity loss noted on gadoxetic acid-enhanced MR images in the rat.	gadolinium ethoxybenzyl DTPA	77-91	ATP binding cassette subfamily C member 2	Rattus norvegicus	121-125
20663976-12	2010	CONCLUSION: Findings showed that liver cirrhosis promotes the elimination of gadoxetic acid mediated by mrp2; therefore, mrp2 up-regulation may explain the significant signal intensity loss noted on gadoxetic acid-enhanced MR images in the rat.	gadolinium ethoxybenzyl DTPA	199-213	ATP binding cassette subfamily C member 2	Rattus norvegicus	121-125
20661702-1	2010	The purpose of this report was to describe pseudolesions of the liver that mimicked residual hypervascular hepatocellular carcinoma (HCC), as observed on gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI) obtained shortly after transarterial chemoembolization (TACE).	gadolinium ethoxybenzyl DTPA	154-173	HCC	Homo sapiens	133-136
20714357-5	2010	The transport of gadoxetic acid from the cytoplasm to the bile is mainly determined by the capacity of the transport protein glutathione-S-transferase.	gadolinium ethoxybenzyl DTPA	17-31	glutathione S-transferase kappa 1	Homo sapiens	125-150
20406852-4	2010	In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM).	gadolinium ethoxybenzyl DTPA	23-34	solute carrier organic anion transporter family member 1B1	Homo sapiens	88-95
20406852-4	2010	In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM).	gadolinium ethoxybenzyl DTPA	23-34	solute carrier organic anion transporter family member 1B3	Homo sapiens	118-125
20406852-9	2010	In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP.	gadolinium ethoxybenzyl DTPA	15-26	solute carrier organic anion transporter family member 1B1	Homo sapiens	64-71
20406852-9	2010	In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP.	gadolinium ethoxybenzyl DTPA	15-26	solute carrier organic anion transporter family member 1B3	Homo sapiens	73-80
20406852-9	2010	In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP.	gadolinium ethoxybenzyl DTPA	15-26	solute carrier family 10 member 1	Homo sapiens	86-90
20661702-3	2010	In all three patients, nontumorous liver tissue adjacent to the treated HCC exhibited focal arterial enhancement on dynamic phase and subsequent diminished uptake of gadoxetate disodium on hepatocellular phase images, which mimicked residual HCC.	gadolinium ethoxybenzyl DTPA	166-185	HCC	Homo sapiens	72-75
20380933-7	2010	Four HCCs were clearly revealed as hypointense only on gadoxetic acid-enhanced hepatocyte phase imaging, but were occult on other sequences, including the SPIO set.	gadolinium ethoxybenzyl DTPA	55-69	holocytochrome c synthase	Homo sapiens	5-9
20380933-8	2010	CONCLUSION: Gadoxetic acid-enhanced MRI is better than SPIO-enhanced MRI for the detection of HCCs.	gadolinium ethoxybenzyl DTPA	12-26	holocytochrome c synthase	Homo sapiens	94-98
18058865-3	2007	The interaction of three gadolinium contrast agents (Gd-EOB-DTPA, Gd-BOPTA and MP-2269) with human serum albumin was assessed through the measurement of proton relaxation rate enhancement in various experimental conditions.	gadolinium ethoxybenzyl DTPA	53-64	albumin	Homo sapiens	99-112
19484243-1	2009	The purpose of this study was to perform an economic evaluation of hepatocyte-specific Gd-EOB-DTPA enhanced MRI (PV-MRI) compared to extracellular contrast-media-enhanced MRI (ECCM-MRI) and three-phase-MDCT as initial modalities in the work-up of patients with metachronous colorectal liver metastases.	gadolinium ethoxybenzyl DTPA	87-98	cell cycle regulator of NHEJ	Homo sapiens	113-119
19404564-0	2009	Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma.	gadolinium ethoxybenzyl DTPA	43-54	solute carrier organic anion transporter family member 1B3	Homo sapiens	14-21
19404564-8	2009	HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001).	gadolinium ethoxybenzyl DTPA	10-21	solute carrier organic anion transporter family member 1B3	Homo sapiens	43-50
19404564-8	2009	HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001).	gadolinium ethoxybenzyl DTPA	10-21	solute carrier organic anion transporter family member 1B3	Homo sapiens	102-109
19404564-9	2009	CONCLUSIONS: Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.	gadolinium ethoxybenzyl DTPA	23-34	solute carrier organic anion transporter family member 1B3	Homo sapiens	73-80
11176256-2	2001	METHODS: Specific uptake of Gd-EOB-DTPA was quantified by relaxometry in rat cultured hepatocytes and the hepatoma cells HepG2 and Huh7.	gadolinium ethoxybenzyl DTPA	28-39	MIR7-3 host gene	Homo sapiens	131-135
11293414-0	2001	Stereospecific binding of MRI contrast agents to human serum albumin: the case of Gd-(S)-EOB-DTPA (Eovist) and its (R) isomer.	gadolinium ethoxybenzyl DTPA	82-97	albumin	Homo sapiens	55-68
10600646-4	2000	Besides the common Oatp substrates bromosulphophthalein, taurocholate, oestrone 3-sulphate and ouabain, the new mouse Oatp also mediates transport of the Oatp1-specific magnetic-resonance-imaging agent gadoxetate.	gadolinium ethoxybenzyl DTPA	202-212	solute carrier organic anion transporter family, member 1a6	Mus musculus	19-23
10600646-4	2000	Besides the common Oatp substrates bromosulphophthalein, taurocholate, oestrone 3-sulphate and ouabain, the new mouse Oatp also mediates transport of the Oatp1-specific magnetic-resonance-imaging agent gadoxetate.	gadolinium ethoxybenzyl DTPA	202-212	solute carrier organic anion transporter family, member 1a6	Mus musculus	118-122
10600646-4	2000	Besides the common Oatp substrates bromosulphophthalein, taurocholate, oestrone 3-sulphate and ouabain, the new mouse Oatp also mediates transport of the Oatp1-specific magnetic-resonance-imaging agent gadoxetate.	gadolinium ethoxybenzyl DTPA	202-212	solute carrier organic anion transporter family, member 1a1	Mus musculus	154-159
10381771-0	1999	Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1.	gadolinium ethoxybenzyl DTPA	64-74	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	121-126
10381771-3	1999	In this study, we demonstrated saturable uptake of gadoxetate by Oatp1 cRNA-injected Xenopus laevis oocytes (Km approximately 3.3 mM).	gadolinium ethoxybenzyl DTPA	51-61	solute carrier organic anion transporter family member 4A1 L homeolog	Xenopus laevis	65-70
10381771-5	1999	Oatp1-mediated gadoxetate uptake (100 microM) could be inhibited by 10 microM bromosulfophthalein (45%), 200 microM taurocholate (92%), 100 microM rifamycin SV (97%), and 100 microM rifampicin (51%).	gadolinium ethoxybenzyl DTPA	15-25	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	0-5
10381771-6	1999	These results show that gadoxetate is a low-affinity substrate of Oatp1.	gadolinium ethoxybenzyl DTPA	24-34	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	66-71
10381771-7	1999	Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver.	gadolinium ethoxybenzyl DTPA	15-25	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	0-5
10381771-7	1999	Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver.	gadolinium ethoxybenzyl DTPA	15-25	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	162-167
10381771-7	1999	Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver.	gadolinium ethoxybenzyl DTPA	197-207	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	0-5
10381771-7	1999	Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver.	gadolinium ethoxybenzyl DTPA	197-207	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	162-167
33034671-2	2020	The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature.	gadolinium ethoxybenzyl DTPA	41-55	ornithine aminotransferase pseudogene 1	Homo sapiens	123-128
8724413-3	1996	After enhancement, lesion-to-liver contrast-to-noise ratios (CNRs) of 47 detected HCCs increased negatively from 3.7 +/- 10.7 (mean +/- SD) to -55.1 +/- 25.8 with Gd-EOB-DTPA (P < .001) and increased positively from 10.4 +/- 10.4 to 26.1 +/- 16.3 with SPIO (P < .001).	gadolinium ethoxybenzyl DTPA	163-174	holocytochrome c synthetase	Mus musculus	82-86
8724413-5	1996	However, Gd-EOB-DTPA positively enhanced four HCCs (8.5%), both highly differentiated (grade 1) and moderately differentiated (grade 2).	gadolinium ethoxybenzyl DTPA	9-20	holocytochrome c synthetase	Mus musculus	46-50
8724413-6	1996	Gd-EOB-DTPA allows the conspicuous detection of small HCCs; however, moderately differentiated HCCs occasionally may be positively enhanced.	gadolinium ethoxybenzyl DTPA	0-11	holocytochrome c synthetase	Mus musculus	54-58
33770738-10	2021	CONCLUSION: OATP1B3 expression was associated with contrast grades of hepatocellular nodules observed in HBP image of gadoxetic acid-enhanced MRI in the hypovascular hepatocellular nodules and was negatively correlated with hepatocarcinogenesis.	gadolinium ethoxybenzyl DTPA	118-132	solute carrier organic anion transporter family member 1B3	Homo sapiens	12-19
10208854-5	1999	Injection into Xenopus laevis oocytes of 5 ng of human OATP cRNA resulted, after 3 days, in a >/=2-fold stimulation (p < 0.001) of transport of Gd-B 20790 but not of Gd-BOPTA or Gd-EOB-DTPA.	gadolinium ethoxybenzyl DTPA	184-195	solute carrier organic anion transporter family member 1A2	Homo sapiens	55-59
33034671-2	2020	The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature.	gadolinium ethoxybenzyl DTPA	41-55	ATP binding cassette subfamily C member 2	Homo sapiens	133-174
33034671-2	2020	The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature.	gadolinium ethoxybenzyl DTPA	41-55	ATP binding cassette subfamily C member 2	Homo sapiens	176-180
33034671-2	2020	The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature.	gadolinium ethoxybenzyl DTPA	41-55	ATP binding cassette subfamily C member 3	Homo sapiens	186-190
34445497-4	2021	We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically available near-infrared (NIR) fluorescent dye.	gadolinium ethoxybenzyl DTPA	127-138	solute carrier organic anion transporter family member 1B3	Homo sapiens	32-81
34738148-0	2022	Gd-EOB-DTPA-enhanced magnetic resonance imaging may help identify patients with hepatocellular carcinoma eligible for treatment targeted at RAF1.	gadolinium ethoxybenzyl DTPA	0-11	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	140-144
34950184-0	2021	Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma.	gadolinium ethoxybenzyl DTPA	70-81	programmed cell death 1	Homo sapiens	131-135
34950184-0	2021	Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma.	gadolinium ethoxybenzyl DTPA	70-81	CD274 molecule	Homo sapiens	136-141
34950184-3	2021	This study aimed to evaluate tumor responses to ICIs using the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), which was shown to reflect Wnt/beta-catenin activating mutation.	gadolinium ethoxybenzyl DTPA	130-141	catenin beta 1	Homo sapiens	217-229
34950184-12	2021	The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.	gadolinium ethoxybenzyl DTPA	58-69	programmed cell death 1	Homo sapiens	162-166
34950184-12	2021	The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC.	gadolinium ethoxybenzyl DTPA	58-69	CD274 molecule	Homo sapiens	167-172
34445497-6	2021	In the OATP1B1 transfected 293T transient expression model, both Gd-BOPTA and Gd-EOB-DTPA uptake were confirmed through 1.5 T MR imaging.	gadolinium ethoxybenzyl DTPA	78-89	solute carrier organic anion transporter family member 1B1	Homo sapiens	7-14
34445497-7	2021	In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA.	gadolinium ethoxybenzyl DTPA	157-168	solute carrier organic anion transporter family member 1B3	Homo sapiens	28-35
34445497-7	2021	In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA.	gadolinium ethoxybenzyl DTPA	157-168	solute carrier organic anion transporter family member 1B3	Homo sapiens	112-119
34476208-3	2021	In the present study, we developed a preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI)-based radiomics model for noninvasive and accurate classification of CK19+ HCC.	gadolinium ethoxybenzyl DTPA	50-64	keratin 19	Homo sapiens	176-180
34327180-0	2021	Preoperative Prediction of Cytokeratin 19 Expression for Hepatocellular Carcinoma with Deep Learning Radiomics Based on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging.	gadolinium ethoxybenzyl DTPA	120-134	keratin 19	Homo sapiens	27-41
34283621-0	2021	Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats.	gadolinium ethoxybenzyl DTPA	112-122	FLVCR heme transporter 2	Rattus norvegicus	50-61
34283621-3	2021	Gadoxetate, a promising magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 (OATP1B1) and multidrug resistance-associated protein 2 (MRP2).	gadolinium ethoxybenzyl DTPA	0-10	ATP binding cassette subfamily C member 2	Rattus norvegicus	148-189
34283621-3	2021	Gadoxetate, a promising magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 (OATP1B1) and multidrug resistance-associated protein 2 (MRP2).	gadolinium ethoxybenzyl DTPA	0-10	ATP binding cassette subfamily C member 2	Rattus norvegicus	191-195
34327180-2	2021	This study aimed to develop and validate the performance of a deep learning radiomics (DLR) model for CK19 identification in HCC based on preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI).	gadolinium ethoxybenzyl DTPA	151-165	keratin 19	Homo sapiens	102-106
34327180-11	2021	Conclusion: This study successfully established and verified an optimal DLR model for preoperative prediction of CK19-positive HCCs based on gadoxetic acid-enhanced MRI.	gadolinium ethoxybenzyl DTPA	141-155	keratin 19	Homo sapiens	113-117
35562264-0	2022	Radiomics on Gadoxetate Disodium-enhanced MRI: Non-invasively Identifying Glypican 3-Positive Hepatocellular Carcinoma and Postoperative Recurrence.	gadolinium ethoxybenzyl DTPA	13-32	glypican 3	Homo sapiens	74-84
35552472-3	2022	Gadoxetic acid is also transported by OATP1B1/1B3, and we aimed to evaluate whether gadoxetic acid-enhanced magnetic resonance (MR) imaging was associated with glecaprevir trough concentrations (Ctrough).	gadolinium ethoxybenzyl DTPA	0-14	solute carrier organic anion transporter family member 1B1	Homo sapiens	38-49
35552472-3	2022	Gadoxetic acid is also transported by OATP1B1/1B3, and we aimed to evaluate whether gadoxetic acid-enhanced magnetic resonance (MR) imaging was associated with glecaprevir trough concentrations (Ctrough).	gadolinium ethoxybenzyl DTPA	84-98	solute carrier organic anion transporter family member 1B1	Homo sapiens	38-49
34298844-1	2021	In hepatocellular carcinoma (HCC), CTNNB-1 mutations, which cause resistance to immune checkpoint inhibitors, are associated with HCC with iso-high intensity in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) in resectable HCC; however, analyses on unresectable HCC are lacking.	gadolinium ethoxybenzyl DTPA	188-202	catenin beta 1	Homo sapiens	35-42
35562264-1	2022	RATIONALE AND OBJECTIVES: To investigate the impact of preoperative gadoxetate disodium (EOB) MRI-based radiomics on predicting glypican 3 (GPC3)-positive expression and the relevant recurrence-free survival (RFS) of HCC <= 5 cm.	gadolinium ethoxybenzyl DTPA	68-87	glypican 3	Homo sapiens	128-138
35562264-1	2022	RATIONALE AND OBJECTIVES: To investigate the impact of preoperative gadoxetate disodium (EOB) MRI-based radiomics on predicting glypican 3 (GPC3)-positive expression and the relevant recurrence-free survival (RFS) of HCC <= 5 cm.	gadolinium ethoxybenzyl DTPA	68-87	glypican 3	Homo sapiens	140-144
35146614-6	2022	As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB).	gadolinium ethoxybenzyl DTPA	180-238	solute carrier organic anion transporter family member 1B3	Homo sapiens	126-133
34928175-6	2022	RESULTS: Using gadoxetic acid-enhanced, 226 lesions were diagnosed as LR-3 or LR-4 by LI-RADS.	gadolinium ethoxybenzyl DTPA	15-29	LDL receptor related protein 5	Homo sapiens	70-74
35146614-6	2022	As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB).	gadolinium ethoxybenzyl DTPA	180-238	solute carrier organic anion transporter family member 1B3	Homo sapiens	83-124
35146614-6	2022	As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB).	gadolinium ethoxybenzyl DTPA	240-251	solute carrier organic anion transporter family member 1B3	Homo sapiens	83-124
35146614-6	2022	As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB).	gadolinium ethoxybenzyl DTPA	240-251	solute carrier organic anion transporter family member 1B3	Homo sapiens	126-133
35070302-1	2022	Previous studies have reported that hepatocellular carcinoma (HCC) harboring WNT/beta-catenin mutations exhibits iso-high intensity by gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI, i.e. EOB-MRI) during the hepatobiliary phase (HBP), thus indicating that EOB-MRI may help clinicians identify an immune exclusion class, which might not respond to treatment with immune checkpoint inhibitors.	gadolinium ethoxybenzyl DTPA	231-242	catenin beta 1	Homo sapiens	81-93
35303023-0	2022	A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats.	gadolinium ethoxybenzyl DTPA	85-104	albumin	Rattus norvegicus	6-13
35303023-14	2022	CONCLUSIONS: A low albumin level is a risk factor for TSM, which could be caused by the effect of gadoxetate disodium on the head and neck region.	gadolinium ethoxybenzyl DTPA	98-117	albumin	Rattus norvegicus	19-26
35159095-2	2022	The hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) has been reported to be useful as an imaging biomarker for detecting beta-catenin mutations.	gadolinium ethoxybenzyl DTPA	27-41	catenin beta 1	Homo sapiens	157-169
35439873-10	2022	CONCLUSION: The combined interpretation of gadoxetate-enhanced MRI and second-line CEUS using Sonazoid, focusing on TP hypointensity, restricted diffusion, and KPD, may be optimal for further characterizing LR-3 and LR-4 observations.	gadolinium ethoxybenzyl DTPA	43-53	LDL receptor related protein 5	Homo sapiens	207-211