PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 11293414-0 2001 Stereospecific binding of MRI contrast agents to human serum albumin: the case of Gd-(S)-EOB-DTPA (Eovist) and its (R) isomer. Gadoxetic acid 82-97 albumin Homo sapiens 55-68 11176256-2 2001 METHODS: Specific uptake of Gd-EOB-DTPA was quantified by relaxometry in rat cultured hepatocytes and the hepatoma cells HepG2 and Huh7. Gadoxetic acid 28-39 MIR7-3 host gene Homo sapiens 131-135 10208854-5 1999 Injection into Xenopus laevis oocytes of 5 ng of human OATP cRNA resulted, after 3 days, in a >/=2-fold stimulation (p < 0.001) of transport of Gd-B 20790 but not of Gd-BOPTA or Gd-EOB-DTPA. Gadoxetic acid 184-195 solute carrier organic anion transporter family member 1A2 Homo sapiens 55-59 10600646-4 2000 Besides the common Oatp substrates bromosulphophthalein, taurocholate, oestrone 3-sulphate and ouabain, the new mouse Oatp also mediates transport of the Oatp1-specific magnetic-resonance-imaging agent gadoxetate. Gadoxetic acid 202-212 solute carrier organic anion transporter family, member 1a6 Mus musculus 19-23 10600646-4 2000 Besides the common Oatp substrates bromosulphophthalein, taurocholate, oestrone 3-sulphate and ouabain, the new mouse Oatp also mediates transport of the Oatp1-specific magnetic-resonance-imaging agent gadoxetate. Gadoxetic acid 202-212 solute carrier organic anion transporter family, member 1a6 Mus musculus 118-122 10600646-4 2000 Besides the common Oatp substrates bromosulphophthalein, taurocholate, oestrone 3-sulphate and ouabain, the new mouse Oatp also mediates transport of the Oatp1-specific magnetic-resonance-imaging agent gadoxetate. Gadoxetic acid 202-212 solute carrier organic anion transporter family, member 1a1 Mus musculus 154-159 10381771-0 1999 Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. Gadoxetic acid 64-74 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 121-126 10381771-3 1999 In this study, we demonstrated saturable uptake of gadoxetate by Oatp1 cRNA-injected Xenopus laevis oocytes (Km approximately 3.3 mM). Gadoxetic acid 51-61 solute carrier organic anion transporter family member 4A1 L homeolog Xenopus laevis 65-70 10381771-5 1999 Oatp1-mediated gadoxetate uptake (100 microM) could be inhibited by 10 microM bromosulfophthalein (45%), 200 microM taurocholate (92%), 100 microM rifamycin SV (97%), and 100 microM rifampicin (51%). Gadoxetic acid 15-25 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 0-5 10381771-6 1999 These results show that gadoxetate is a low-affinity substrate of Oatp1. Gadoxetic acid 24-34 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 66-71 10381771-7 1999 Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver. Gadoxetic acid 15-25 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 0-5 10381771-7 1999 Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver. Gadoxetic acid 15-25 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 162-167 10381771-7 1999 Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver. Gadoxetic acid 197-207 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 0-5 10381771-7 1999 Oatp1-mediated gadoxetate transport demonstrated a similar apparent Km value and cis-inhibition pattern as previously determined in rats in vivo, indicating that Oatp1 is significantly involved in gadoxetate uptake into rat liver. Gadoxetic acid 197-207 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 162-167 8724413-3 1996 After enhancement, lesion-to-liver contrast-to-noise ratios (CNRs) of 47 detected HCCs increased negatively from 3.7 +/- 10.7 (mean +/- SD) to -55.1 +/- 25.8 with Gd-EOB-DTPA (P < .001) and increased positively from 10.4 +/- 10.4 to 26.1 +/- 16.3 with SPIO (P < .001). Gadoxetic acid 163-174 holocytochrome c synthetase Mus musculus 82-86 8724413-5 1996 However, Gd-EOB-DTPA positively enhanced four HCCs (8.5%), both highly differentiated (grade 1) and moderately differentiated (grade 2). Gadoxetic acid 9-20 holocytochrome c synthetase Mus musculus 46-50 8724413-6 1996 Gd-EOB-DTPA allows the conspicuous detection of small HCCs; however, moderately differentiated HCCs occasionally may be positively enhanced. Gadoxetic acid 0-11 holocytochrome c synthetase Mus musculus 54-58 33770738-10 2021 CONCLUSION: OATP1B3 expression was associated with contrast grades of hepatocellular nodules observed in HBP image of gadoxetic acid-enhanced MRI in the hypovascular hepatocellular nodules and was negatively correlated with hepatocarcinogenesis. Gadoxetic acid 118-132 solute carrier organic anion transporter family member 1B3 Homo sapiens 12-19 34298844-1 2021 In hepatocellular carcinoma (HCC), CTNNB-1 mutations, which cause resistance to immune checkpoint inhibitors, are associated with HCC with iso-high intensity in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) in resectable HCC; however, analyses on unresectable HCC are lacking. Gadoxetic acid 188-202 catenin beta 1 Homo sapiens 35-42 33034671-2 2020 The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature. Gadoxetic acid 41-55 ornithine aminotransferase pseudogene 1 Homo sapiens 123-128 33034671-2 2020 The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature. Gadoxetic acid 41-55 ATP binding cassette subfamily C member 2 Homo sapiens 133-174 33034671-2 2020 The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature. Gadoxetic acid 41-55 ATP binding cassette subfamily C member 2 Homo sapiens 176-180 33034671-2 2020 The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2 (MRP2) and MRP3, has been elucidated in the literature. Gadoxetic acid 41-55 ATP binding cassette subfamily C member 3 Homo sapiens 186-190 34738148-0 2022 Gd-EOB-DTPA-enhanced magnetic resonance imaging may help identify patients with hepatocellular carcinoma eligible for treatment targeted at RAF1. Gadoxetic acid 0-11 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 140-144 34445497-4 2021 We previously reported that the organic anion transporting polypeptide (OATP) 1B3 has an uptake capability for both MR agents (Gd-EOB-DTPA) and indocyanine green (ICG), a clinically available near-infrared (NIR) fluorescent dye. Gadoxetic acid 127-138 solute carrier organic anion transporter family member 1B3 Homo sapiens 32-81 34445497-6 2021 In the OATP1B1 transfected 293T transient expression model, both Gd-BOPTA and Gd-EOB-DTPA uptake were confirmed through 1.5 T MR imaging. Gadoxetic acid 78-89 solute carrier organic anion transporter family member 1B1 Homo sapiens 7-14 34445497-7 2021 In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA. Gadoxetic acid 157-168 solute carrier organic anion transporter family member 1B3 Homo sapiens 28-35 34445497-7 2021 In the constant OAPT1B1 and OATP1B3 expression model in the HT-1080 cell line, both HT-1080-OAPT1B1 and HT-1080-OATP1B3 were observed to ingest Gd-BOPTA and Gd-EOB-DTPA. Gadoxetic acid 157-168 solute carrier organic anion transporter family member 1B3 Homo sapiens 112-119 34950184-0 2021 Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma. Gadoxetic acid 70-81 programmed cell death 1 Homo sapiens 131-135 34950184-0 2021 Higher Enhancement Intrahepatic Nodules on the Hepatobiliary Phase of Gd-EOB-DTPA-Enhanced MRI as a Poor Responsive Marker of Anti-PD-1/PD-L1 Monotherapy for Unresectable Hepatocellular Carcinoma. Gadoxetic acid 70-81 CD274 molecule Homo sapiens 136-141 34950184-3 2021 This study aimed to evaluate tumor responses to ICIs using the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), which was shown to reflect Wnt/beta-catenin activating mutation. Gadoxetic acid 130-141 catenin beta 1 Homo sapiens 217-229 34950184-12 2021 The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC. Gadoxetic acid 58-69 programmed cell death 1 Homo sapiens 162-166 34950184-12 2021 The intensity of the nodule on the hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI is a promising imaging biomarker for predicting unfavorable response with anti-PD-1/PD-L1 monotherapy in patients with HCC. Gadoxetic acid 58-69 CD274 molecule Homo sapiens 167-172 34476208-3 2021 In the present study, we developed a preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI)-based radiomics model for noninvasive and accurate classification of CK19+ HCC. Gadoxetic acid 50-64 keratin 19 Homo sapiens 176-180 34283621-0 2021 Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats. Gadoxetic acid 112-122 FLVCR heme transporter 2 Rattus norvegicus 50-61 34283621-3 2021 Gadoxetate, a promising magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 (OATP1B1) and multidrug resistance-associated protein 2 (MRP2). Gadoxetic acid 0-10 ATP binding cassette subfamily C member 2 Rattus norvegicus 148-189 34283621-3 2021 Gadoxetate, a promising magnetic resonance imaging (MRI) contrast agent, is a substrate of organic-anion-transporting polypeptide 1B1 (OATP1B1) and multidrug resistance-associated protein 2 (MRP2). Gadoxetic acid 0-10 ATP binding cassette subfamily C member 2 Rattus norvegicus 191-195 34327180-0 2021 Preoperative Prediction of Cytokeratin 19 Expression for Hepatocellular Carcinoma with Deep Learning Radiomics Based on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging. Gadoxetic acid 120-134 keratin 19 Homo sapiens 27-41 34327180-2 2021 This study aimed to develop and validate the performance of a deep learning radiomics (DLR) model for CK19 identification in HCC based on preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI). Gadoxetic acid 151-165 keratin 19 Homo sapiens 102-106 34327180-11 2021 Conclusion: This study successfully established and verified an optimal DLR model for preoperative prediction of CK19-positive HCCs based on gadoxetic acid-enhanced MRI. Gadoxetic acid 141-155 keratin 19 Homo sapiens 113-117 34928175-6 2022 RESULTS: Using gadoxetic acid-enhanced, 226 lesions were diagnosed as LR-3 or LR-4 by LI-RADS. Gadoxetic acid 15-29 LDL receptor related protein 5 Homo sapiens 70-74 35552472-3 2022 Gadoxetic acid is also transported by OATP1B1/1B3, and we aimed to evaluate whether gadoxetic acid-enhanced magnetic resonance (MR) imaging was associated with glecaprevir trough concentrations (Ctrough). Gadoxetic acid 0-14 solute carrier organic anion transporter family member 1B1 Homo sapiens 38-49 35552472-3 2022 Gadoxetic acid is also transported by OATP1B1/1B3, and we aimed to evaluate whether gadoxetic acid-enhanced magnetic resonance (MR) imaging was associated with glecaprevir trough concentrations (Ctrough). Gadoxetic acid 84-98 solute carrier organic anion transporter family member 1B1 Homo sapiens 38-49 35562264-0 2022 Radiomics on Gadoxetate Disodium-enhanced MRI: Non-invasively Identifying Glypican 3-Positive Hepatocellular Carcinoma and Postoperative Recurrence. Gadoxetic acid 13-32 glypican 3 Homo sapiens 74-84 35562264-1 2022 RATIONALE AND OBJECTIVES: To investigate the impact of preoperative gadoxetate disodium (EOB) MRI-based radiomics on predicting glypican 3 (GPC3)-positive expression and the relevant recurrence-free survival (RFS) of HCC <= 5 cm. Gadoxetic acid 68-87 glypican 3 Homo sapiens 128-138 35562264-1 2022 RATIONALE AND OBJECTIVES: To investigate the impact of preoperative gadoxetate disodium (EOB) MRI-based radiomics on predicting glypican 3 (GPC3)-positive expression and the relevant recurrence-free survival (RFS) of HCC <= 5 cm. Gadoxetic acid 68-87 glypican 3 Homo sapiens 140-144 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). Gadoxetic acid 180-238 solute carrier organic anion transporter family member 1B3 Homo sapiens 126-133 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). Gadoxetic acid 240-251 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-124 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). Gadoxetic acid 180-238 solute carrier organic anion transporter family member 1B3 Homo sapiens 83-124 35146614-6 2022 As a proof-of-concept, breast cancer cells were engineered to co-express the human organic anion transporter polypeptide 1B3 (OATP1B3) that uptakes the clinical MRI contrast agent gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), and the human sodium iodide symporter (NIS) which uptakes the PET tracer, (18F) tetrafluoroborate ((18F) TFB). Gadoxetic acid 240-251 solute carrier organic anion transporter family member 1B3 Homo sapiens 126-133 35439873-10 2022 CONCLUSION: The combined interpretation of gadoxetate-enhanced MRI and second-line CEUS using Sonazoid, focusing on TP hypointensity, restricted diffusion, and KPD, may be optimal for further characterizing LR-3 and LR-4 observations. Gadoxetic acid 43-53 LDL receptor related protein 5 Homo sapiens 207-211 35303023-0 2022 A low albumin level as a risk factor for transient severe motion artifact induced by gadoxetate disodium administration: A retrospective observational study with free-breathing dynamic MRI and an experimental study in rats. Gadoxetic acid 85-104 albumin Rattus norvegicus 6-13 35303023-14 2022 CONCLUSIONS: A low albumin level is a risk factor for TSM, which could be caused by the effect of gadoxetate disodium on the head and neck region. Gadoxetic acid 98-117 albumin Rattus norvegicus 19-26 35159095-2 2022 The hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) has been reported to be useful as an imaging biomarker for detecting beta-catenin mutations. Gadoxetic acid 27-41 catenin beta 1 Homo sapiens 157-169 35070302-1 2022 Previous studies have reported that hepatocellular carcinoma (HCC) harboring WNT/beta-catenin mutations exhibits iso-high intensity by gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI, i.e. EOB-MRI) during the hepatobiliary phase (HBP), thus indicating that EOB-MRI may help clinicians identify an immune exclusion class, which might not respond to treatment with immune checkpoint inhibitors. Gadoxetic acid 231-242 catenin beta 1 Homo sapiens 81-93 33993366-0 2022 Imaging features of gadoxetic acid-enhanced MR imaging for evaluation of tumor-infiltrating CD8 cells and PD-L1 expression in hepatocellular carcinoma. Gadoxetic acid 20-34 CD8a molecule Homo sapiens 92-95 33993366-0 2022 Imaging features of gadoxetic acid-enhanced MR imaging for evaluation of tumor-infiltrating CD8 cells and PD-L1 expression in hepatocellular carcinoma. Gadoxetic acid 20-34 CD274 molecule Homo sapiens 106-111 33993366-2 2022 We aimed to determine the ability of preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings to predict CD8 cell density and PD-L1 expression in HCC. Gadoxetic acid 50-64 CD8a molecule Homo sapiens 127-130 33993366-2 2022 We aimed to determine the ability of preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI) findings to predict CD8 cell density and PD-L1 expression in HCC. Gadoxetic acid 50-64 CD274 molecule Homo sapiens 148-153 33883364-1 2021 PURPOSE: To evaluate the utility of T2-enhanced spin-echo imaging using the time-reversed gradient echo sequence (T2FFE imaging) in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for differentiating hemangiomas from metastatic tumors. Gadoxetic acid 165-179 spindlin 1 Homo sapiens 48-52 33084108-0 2021 Unusual Distribution Kinetics of Gadoxetate in Healthy Human Subjects Genotyped for OATP1B1: Application of Population Analysis and a Minimal Physiological-Based Pharmacokinetic Model. Gadoxetic acid 33-43 solute carrier organic anion transporter family member 1B1 Homo sapiens 84-91 33084108-6 2021 In elucidating the impact of OATP1B1 genotype (*1a/*1a and *15/*15) on the pharmacokinetics of gadoxetate, we found that tissue uptake and back-transfer rates were significantly reduced, whereas the hepatic sinusoidal efflux rate was significantly increased in carriers of the *15/*15 haplotype compared with those of the *1a/*1a (wild type). Gadoxetic acid 95-105 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-36 33707581-2 2021 Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers. Gadoxetic acid 0-19 solute carrier organic anion transporter family member 1B3 Homo sapiens 38-45 33707581-2 2021 Gadoxetate disodium is a substrate of OATP1B3, and its uptake has been shown to correlate with OATP1B3 expression in other cancers. Gadoxetic acid 0-19 solute carrier organic anion transporter family member 1B3 Homo sapiens 95-102 33603462-0 2021 OATP1B3 Expression in Hepatocellular Carcinoma Correlates with Intralesional Gd-EOB-DTPA Uptake and Signal Intensity on Gd-EOB-DTPA-Enhanced MRI. Gadoxetic acid 77-88 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-7 33603462-1 2021 Background: To evaluate the predictive value of the OATP1B3 expression in hepatocellular carcinoma (HCC) for the gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) uptake and the signal intensity (SI) in the hepatobiliary (HB) phase. Gadoxetic acid 113-171 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-59 33603462-1 2021 Background: To evaluate the predictive value of the OATP1B3 expression in hepatocellular carcinoma (HCC) for the gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) uptake and the signal intensity (SI) in the hepatobiliary (HB) phase. Gadoxetic acid 173-184 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-59 33603462-9 2021 Conclusion: The OATP1B3 expression in HCC can predict the uptake of Gd-EOB-DTPA and the SI of the HB phase. Gadoxetic acid 68-79 solute carrier organic anion transporter family member 1B3 Homo sapiens 16-23 32836213-9 2020 CONCLUSION: LR-3 and LR-4 without APHE were often downgraded or remained stable in category on Gd-EOB-DTPA-enhanced MRI follow-up. Gadoxetic acid 95-106 LDL receptor related protein 5 Homo sapiens 12-16 32556463-1 2020 OBJECTIVES: To reveal the utility of motion artifact reduction with convolutional neural network (MARC) in gadoxetate disodium-enhanced multi-arterial phase MRI of the liver. Gadoxetic acid 107-126 C-C motif chemokine ligand 7 Homo sapiens 98-102 32556463-11 2020 CONCLUSIONS: Motion artifacts and lesion conspicuity of gadoxetate disodium-enhanced arterial phase liver MRI were significantly improved by the MARC filter, especially in cases with substantial artifacts. Gadoxetic acid 56-66 C-C motif chemokine ligand 7 Homo sapiens 145-149 32556463-14 2020 MARC significantly improved MR image quality after gadoxetate disodium administration by reducing motion artifacts, especially in cases with severely degraded images. Gadoxetic acid 51-70 C-C motif chemokine ligand 7 Homo sapiens 0-4 32468212-1 2020 PURPOSE: To identify gadoxetate disodium-enhanced MRI features distinguishing hepatic IPT from CLM. Gadoxetic acid 21-40 tRNA isopentenyltransferase 1 Homo sapiens 86-89 32458127-6 2020 Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes. Gadoxetic acid 161-175 solute carrier organic anion transporter family member 1B3 Homo sapiens 52-101 32458127-6 2020 Our study also investigated the expression level of organic anion transporting polypeptide (OATP) 1B3 and OATP1B1/1B3, which is related to the uptake of ICG and gadoxetic acid into hepatocytes. Gadoxetic acid 161-175 solute carrier organic anion transporter family member 1B1 Homo sapiens 106-117 32333148-1 2020 OBJECTIVES: To compare diagnostic performances of current guidelines for the diagnosis of HCC in LT candidates using gadoxetic acid-enhanced liver MRI (Gd-EOB-MRI). Gadoxetic acid 117-131 cell cycle regulator of NHEJ Homo sapiens 152-162 33083276-0 2020 Gd-EOB-DTPA-MRI Could Predict WNT/beta-Catenin Mutation and Resistance to Immune Checkpoint Inhibitor Therapy in Hepatocellular Carcinoma. Gadoxetic acid 0-11 catenin beta 1 Homo sapiens 34-46 32468212-7 2020 CONCLUSION: Central hypointensity with a relatively peripheral hyperintensity on HBP and SIRlesion/liver on HBP and DWI may be reliable gadoxetate disodium-enhanced MRI features for distinguishing IPT from CLM. Gadoxetic acid 136-146 tRNA isopentenyltransferase 1 Homo sapiens 197-200 32064560-3 2020 Gadoxetic acid-enhanced MRI, an indirect molecular imaging method, reflects OATP1B3 expression in HCC. Gadoxetic acid 0-14 solute carrier organic anion transporter family member 1B3 Homo sapiens 76-83 32166493-14 2020 CONCLUSION: Noncontrast and abbreviated MRI using gadoxetic acid showed comparable diagnostic performance for detecting patients with HCCs in the early stage. Gadoxetic acid 50-64 holocytochrome c synthase Homo sapiens 134-138 32166493-15 2020 KEY POINTS: Diagnostic performance of noncontrast MRI and abbreviated MRI using gadoxetic acid for detecting HCCs is comparable in patients with HCCs in the early stage. Gadoxetic acid 82-96 holocytochrome c synthase Homo sapiens 111-115 32033745-9 2020 CONCLUSION: A considerable proportion of HCCs could have been categorised as LR-M as they had a targetoid appearance on gadoxetic acid-enhanced MRI. Gadoxetic acid 120-134 holocytochrome c synthase Homo sapiens 41-45 31834849-5 2020 The tumor cells of some types of hepatocellular adenoma (eg, beta-catenin-activated type, inflammatory type) and hepatocellular carcinoma (eg, green hepatoma) can show uptake of gadoxetic acid. Gadoxetic acid 178-192 catenin beta 1 Homo sapiens 61-73 32002645-0 2020 A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI. Gadoxetic acid 87-101 keratin 19 Homo sapiens 32-46 32002645-10 2020 CONCLUSIONS: The combined model based on a fusion radiomics signature derived from arterial and hepatobiliary phase images of gadoxetic acid-enhanced MRI can be a reliable biomarker for CK19 status of HCC. Gadoxetic acid 126-140 keratin 19 Homo sapiens 186-190 32002645-11 2020 KEY POINTS: Arterial rim enhancement pattern and irregular tumor margin on hepatobiliary phase on gadoxetic acid-enhanced MRI can be useful for evaluating CK19 status of HCC. Gadoxetic acid 100-114 keratin 19 Homo sapiens 157-161 31917760-1 2020 OBJECTIVES: The aim of this study was to develop a method to determine hepatic and renal clearance of the 2 diastereoisomers (Gd-A, Gd-B) of Gd-EOB-DTPA separately. Gadoxetic acid 141-152 guanine deaminase Homo sapiens 126-130 32410411-11 2020 CONCLUSION: The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI. Gadoxetic acid 137-151 solute carrier organic anion transporter family member 1B3 Homo sapiens 33-40 32410411-11 2020 CONCLUSION: The human endogenous OATP1B3 gene can be non-virally delivered into cells to induce transient OATP1B3 expression, leading to gadoxetic acid-mediated enhancement on MRI. Gadoxetic acid 137-151 solute carrier organic anion transporter family member 1B3 Homo sapiens 106-113 31939096-3 2020 The preoperative Gd-EOB-DTPA MRI showed a 2.7-cm HCC located in segment VIII. Gadoxetic acid 17-28 cytochrome c oxidase subunit 8A Homo sapiens 72-76 31179770-6 2021 The inhibitory activities of gadoteric acid, gadopentetic acid, gadoxetate disodium, and gadodiamide were investigated on PON1 activity of the enzyme. Gadoxetic acid 64-83 paraoxonase 1 Homo sapiens 122-126 31400382-6 2019 Additionally, PET imaging with the integrin alpha6 targeted 18F-RWY enabled to visualize small HCC lesions with diameters approximately 0.2 cm that was hard to be distinguished from surround hepatic vascular by enhanced MRI with Gd-EOB-DTPA. Gadoxetic acid 229-240 integrin alpha 6 Mus musculus 35-50 31179770-10 2021 In addition, the molecular docking analyses of gadoxetate disodium and gadodiamide were carried out to understand the binding interactions on the active site of the PON1 enzyme. Gadoxetic acid 47-66 paraoxonase 1 Homo sapiens 165-169 30465867-9 2019 DCE-MRI with Gd-EOB-DTPA showed that Tmax and T1/2 were significantly longer in MC4R-KO mice fed an HFD compared with wild type (WT) mice (Tmax, WT, 3.9 +- 0.4 min; MC4R-KO, 7.4 +- 1.5 min; T1/2, WT, 23.7 +- 1.9 min; MC4R-KO, 62.5 +- 18.5 min). Gadoxetic acid 13-24 melanocortin 4 receptor Mus musculus 80-84 31210715-2 2019 Current state-of-the-art magnetic resonance imaging (MRI) using gadoxetic acid provides many imaging features that could potentially be used to classify single HCC as pT1 or pT2. Gadoxetic acid 64-78 zinc finger protein 77 Homo sapiens 167-170 31210715-3 2019 AIM: To determine which gadoxetic acid-enhanced MRI (EOB-MRI) findings predict pathologic stage T2 in patients with solitary HCC (cT1). Gadoxetic acid 24-38 cardiotrophin 1 Homo sapiens 130-133 30672844-5 2019 Oatp1a1 operates by transporting gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) into cells, and it concomitantly improves BLI substrate uptake. Gadoxetic acid 94-105 solute carrier organic anion transporter family, member 1a1 Mus musculus 0-7 30672844-8 2019 On MRI, post-Gd-EOB-DTPA T1-weighted images of Oatp1a1-expressing tumors exhibited significantly increased contrast-to-noise ratios compared with control tumors and precontrast images (P < 0.05). Gadoxetic acid 13-24 solute carrier organic anion transporter family, member 1a1 Mus musculus 47-54 30465867-12 2019 The liver kinetics of Gd-EOB-DTPA were significantly different in MC4R-KO mice fed an HFD from WT mice, and correlated with the histopathologic score. Gadoxetic acid 22-33 melanocortin 4 receptor Mus musculus 66-70 30487262-4 2019 OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA). Gadoxetic acid 135-154 solute carrier organic anion transporter family, member 1a1 Mus musculus 0-7 30487262-4 2019 OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA). Gadoxetic acid 135-154 solute carrier organic anion transporter family, member 1b2 Mus musculus 12-19 30487262-4 2019 OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA). Gadoxetic acid 156-167 solute carrier organic anion transporter family, member 1a1 Mus musculus 0-7 30487262-4 2019 OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA). Gadoxetic acid 156-167 solute carrier organic anion transporter family, member 1b2 Mus musculus 12-19 29391764-1 2018 AIM: To optimize the hepatobiliary phase delay time (HBP-DT) of Gd-EOB-DTPA-enhanced magnetic resonance imaging (GED-MRI) for more efficient identification of hepatocellular carcinoma (HCC) occurring in different degrees of cirrhosis assessed by Child-Pugh (CP) score. Gadoxetic acid 64-75 heme binding protein 1 Homo sapiens 53-56 29695578-0 2018 cDNA Microarray Analysis and Influx Transporter OATP1B1 in Liver Cells After Exposure to Gadoxetate Disodium, a Gadolinium-based Contrast Agent in MRI Liver Imaging. Gadoxetic acid 89-108 solute carrier organic anion transporter family member 1B1 Homo sapiens 48-55 29695578-9 2018 The SLCO1C1 (solute carrier organic anion transporter family member 1C1) mRNA expression was also increased by 2.62-fold (p-value=0.0006) in gadoxetate disodium-treated cells. Gadoxetic acid 141-160 solute carrier organic anion transporter family member 1C1 Homo sapiens 4-11 29695578-9 2018 The SLCO1C1 (solute carrier organic anion transporter family member 1C1) mRNA expression was also increased by 2.62-fold (p-value=0.0006) in gadoxetate disodium-treated cells. Gadoxetic acid 141-160 solute carrier organic anion transporter family member 1C1 Homo sapiens 13-71 29695578-10 2018 Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression. Gadoxetic acid 44-54 solute carrier organic anion transporter family member 1B1 Homo sapiens 77-118 29695578-10 2018 Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression. Gadoxetic acid 44-54 solute carrier organic anion transporter family member 1B1 Homo sapiens 120-127 29695578-10 2018 Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression. Gadoxetic acid 44-54 solute carrier organic anion transporter family member 1A2 Homo sapiens 120-124 29695578-10 2018 Furthermore, we also checked and found that gadoxetate disodium up-regulated organic anion transporter polypeptide 1B1 (OATP1B1) protein level and increased OATP uptake transporter gene SLCO1C1 mRNA expression. Gadoxetic acid 44-54 solute carrier organic anion transporter family member 1C1 Homo sapiens 186-193 29709031-0 2018 Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin. Gadoxetic acid 0-14 solute carrier organic anion transporter family member 1B1 Homo sapiens 169-217 29709031-0 2018 Gadoxetic acid-enhanced magnetic resonance imaging to predict paritaprevir-induced hyperbilirubinemia during treatment of hepatitis C. BACKGROUND: Paritaprevir inhibits organic anion-transporting polypeptide (OATP)1B1 and OATP1B3, which transport bilirubin. Gadoxetic acid 0-14 solute carrier organic anion transporter family member 1B3 Homo sapiens 222-229 29709031-2 2018 Gadoxetic acid is also transported by OATP1B1/1B3. Gadoxetic acid 0-14 solute carrier organic anion transporter family member 1B1 Homo sapiens 38-49 29166246-0 2018 Imaging Features of Gadoxetic Acid-enhanced and Diffusion-weighted MR Imaging for Identifying Cytokeratin 19-positive Hepatocellular Carcinoma: A Retrospective Observational Study. Gadoxetic acid 20-34 keratin 19 Homo sapiens 94-108 28488786-0 2018 Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of beta-catenin and hepatocyte nuclear factor 4alpha in hepatocellular carcinoma. Gadoxetic acid 0-14 catenin beta 1 Homo sapiens 77-89 28488786-1 2018 AIM: The aim of this study is to clarify the correlation of the co-activation of beta-catenin and hepatocyte nuclear factor (HNF)4alpha with the findings of gadoxetic acid-enhanced magnetic resonance imaging (MRI), organic anion transporting polypeptide (OATP)1B3 expression, and histological findings in hepatocellular carcinoma (HCC). Gadoxetic acid 157-171 catenin beta 1 Homo sapiens 81-93 30218633-0 2019 OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy. Gadoxetic acid 65-76 ATP binding cassette subfamily C member 3 Homo sapiens 14-18 30218633-11 2019 CONCLUSIONS: OATPB1/B3 and MRP3 IHC and signal intensity on HBP Gd-EOB-DTPA-enhanced MRI can help to stratify HCA according to their risk of malignant transformation. Gadoxetic acid 64-75 ATP binding cassette subfamily C member 3 Homo sapiens 27-31 29651770-10 2018 Thus, gadoxetate disodium inhibited the ATP-binding cassette sub-family C member 2 transporter. Gadoxetic acid 6-25 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus 40-82 29166246-12 2018 Conclusion At gadoxetic acid-enhanced and diffusion-weighted MR imaging, irregular margin, arterial phase rim enhancement, lower tumor-to-liver ADC ratio, and lower tumor-to-liver SI ratio at HBP imaging may be helpful to predict CK19-positive HCC with early recurrence (<2 years) after curative resection. Gadoxetic acid 14-28 keratin 19 Homo sapiens 230-234 28488786-6 2018 RESULTS: Enhancement ratio on gadoxetic acid-enhanced MRI in HCC with beta-catenin/GS (+) HNF4alpha (+) was significantly higher than those of the other three groups (P < 0.001). Gadoxetic acid 30-44 catenin beta 1 Homo sapiens 70-82 28488786-6 2018 RESULTS: Enhancement ratio on gadoxetic acid-enhanced MRI in HCC with beta-catenin/GS (+) HNF4alpha (+) was significantly higher than those of the other three groups (P < 0.001). Gadoxetic acid 30-44 hepatocyte nuclear factor 4 alpha Homo sapiens 90-99 28488786-10 2018 CONCLUSION: Co-activation of beta-catenin and HNF4alpha would promote OATP1B3 expression, and consequently higher enhancement ratio on gadoxetic acid-enhanced MRI and higher differentiation grade in HCC. Gadoxetic acid 135-149 catenin beta 1 Homo sapiens 29-41 28488786-10 2018 CONCLUSION: Co-activation of beta-catenin and HNF4alpha would promote OATP1B3 expression, and consequently higher enhancement ratio on gadoxetic acid-enhanced MRI and higher differentiation grade in HCC. Gadoxetic acid 135-149 hepatocyte nuclear factor 4 alpha Homo sapiens 46-55 28444420-6 2017 CONCLUSIONS: Fat-suppressed T2-weighted MR imaging with 3D-VISTA acquired after the hepatobiliary phase on Gd-EOB-DTPA-enhanced imaging may be a useful noninvasive method for evaluating the periportal lymphatic system and the degree of hepatic fibrosis. Gadoxetic acid 107-118 V-set immunoregulatory receptor Homo sapiens 59-64 29254310-1 2017 The aim of this study was to investigate the value of Gd-EOB-DTPA-enhanced MRI on hepatobiliary phase (HBP) imaging and T1 mapping sequence in the differentiation of hepatocellular carcinoma (HCC). Gadoxetic acid 54-65 heme binding protein 1 Homo sapiens 103-106 29254310-16 2017 T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC. Gadoxetic acid 38-49 CD5 molecule Homo sapiens 0-2 29254310-16 2017 T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC. Gadoxetic acid 38-49 heme binding protein 1 Homo sapiens 31-34 29254310-16 2017 T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC. Gadoxetic acid 38-49 heme binding protein 1 Homo sapiens 97-100 29254310-16 2017 T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC. Gadoxetic acid 104-115 CD5 molecule Homo sapiens 0-2 29254310-16 2017 T1 mapping in pre-contrast and HBP of Gd-EOB-DTPA-enhanced MRI, a non-smooth tumor margin in the HBP of Gd-EOB-DTPA-enhanced MRI, are useful in predicting the pathologic grading of HCC. Gadoxetic acid 104-115 heme binding protein 1 Homo sapiens 97-100 28709718-10 2017 CONCLUSION: View-sharing mHAP was feasible without compromising image quality and contributed to the improvement in diagnostic confidence for hypervascular HCC in gadoxetic acid-enhance MR imaging. Gadoxetic acid 163-177 retinoic acid receptor, beta Mus musculus 25-29 28609188-1 2017 OBJECTIVE: The purpose of this study is to evaluate the effect of subtraction images of gadoxetic acid-enhanced MRI on the image interpretation of focal hepatic lesions in patients at risk for hepatocellular carcinoma (HCC). Gadoxetic acid 88-102 HCC Homo sapiens 219-222 28624009-11 2017 CONCLUSION: T1 relaxation time at post-contrast of Gd-EOB-DTPA (T1hb) was strongly correlated with ICG clearance and moderately correlated HH15 with 99mTc-GSA. Gadoxetic acid 51-62 GNAS complex locus Homo sapiens 155-158 29050339-0 2017 Aberrant expression of OATP1B3 in colorectal cancer liver metastases and its clinical implication on gadoxetic acid-enhanced MRI. Gadoxetic acid 101-115 solute carrier organic anion transporter family member 1B3 Homo sapiens 23-30 27957635-7 2017 CONCLUSION: Although enhancement patterns of recurrent HCC in transplanted liver did not affect OS and TTR, these HCCs that arise after LT frequently revealed atypical enhancement on gadoxetic acid-enhanced MR imaging. Gadoxetic acid 183-197 holocytochrome c synthase Homo sapiens 114-118 27957635-8 2017 KEY POINTS: Recurrent HCCs after LT showed atypical enhancement on gadoxetic acid-enhanced MRI. Gadoxetic acid 69-83 holocytochrome c synthase Homo sapiens 24-28 27780379-2 2017 We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI). Gadoxetic acid 115-129 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 65-70 27780379-2 2017 We hypothesize that hepatocyte expressions of bile transporters (OATP1 and MRP2) correlate with dynamic profile of Gadoxetic acid enhanced (GE)-MR imaging (MRI). Gadoxetic acid 115-129 ATP binding cassette subfamily C member 2 Rattus norvegicus 75-79 26205638-6 2016 RESULTS: Significant changes of T1 relaxation times between non-enhanced and gadoxetate disodium-enhanced MRI at HP1 and HP2 could be observed in all liver segments (p < 0.0001). Gadoxetic acid 77-96 chromobox 5 Homo sapiens 113-116 28266528-2 2017 Due to its OATP1B1/B3-dependent hepatocyte-specific uptake and paramagnetic properties increasing evidence has emerged to suggest that Gd-EOB-DTPA-enhanced MRI can be potentially used for evaluation of liver function. Gadoxetic acid 135-146 solute carrier organic anion transporter family member 1B1 Homo sapiens 11-18 27195437-13 2016 PT activity of at least 86.9% could be used to shorten examination times at Gd-EOB-DTPA-enhanced MR imaging. Gadoxetic acid 76-87 coagulation factor II, thrombin Homo sapiens 0-2 26130441-10 2016 CONCLUSIONS: The sensitivity for preoperative detection of HCCs was higher for gadoxetic acid-enhanced MRI than for multiphasic MDCT imaging. Gadoxetic acid 79-93 holocytochrome c synthase Homo sapiens 59-63 26693795-2 2016 Gadoxetate demonstrates unique pharmacokinetic and pharmacodynamic properties, because its uptake in hepatocytes occurs via the organic anion transporting polypeptide (OATP) transporter expressed at the sinusoidal membrane, and its biliary excretion via the multidrug resistance-associated proteins (MRPs) at the canalicular membrane. Gadoxetic acid 0-10 solute carrier organic anion transporter family member 1A2 Homo sapiens 128-166 26693795-2 2016 Gadoxetate demonstrates unique pharmacokinetic and pharmacodynamic properties, because its uptake in hepatocytes occurs via the organic anion transporting polypeptide (OATP) transporter expressed at the sinusoidal membrane, and its biliary excretion via the multidrug resistance-associated proteins (MRPs) at the canalicular membrane. Gadoxetic acid 0-10 solute carrier organic anion transporter family member 1A2 Homo sapiens 168-172 26076199-14 2015 CONCLUSION: Ktrans and iAUC obtained from DCE-MRI with Gd-EOB-DTPA are useful for the detection and staging of rat liver fibrosis induced by CCl4. Gadoxetic acid 55-66 C-C motif chemokine ligand 4 Rattus norvegicus 141-145 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. Gadoxetic acid 81-140 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-37 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. Gadoxetic acid 81-140 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-46 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. Gadoxetic acid 142-153 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-37 25560223-2 2015 Organic anion transporter peptide 1B3 (OATP1B3), which transports agents such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), has reduced expression in the late stages of PBC. Gadoxetic acid 142-153 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-46 26187715-0 2015 Correlation between Gd-EOB-DTPA-enhanced MR imaging findings and OATP1B3 expression in chemotherapy-associated sinusoidal obstruction syndrome. Gadoxetic acid 20-31 solute carrier organic anion transporter family member 1B3 Homo sapiens 65-72 25985059-11 2015 The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP. Gadoxetic acid 74-88 solute carrier organic anion transporter family member 1B1 Homo sapiens 14-21 25985059-11 2015 The degree of OATP1B1/3 and MRP3 expression correlated statistically with gadoxetic acid retention and washout, respectively, in the HBP. Gadoxetic acid 74-88 ATP binding cassette subfamily C member 3 Homo sapiens 28-32 25820755-9 2015 CONCLUSIONS: A simultaneous PET/MRI using both (68)Ga-DOTA-TOC and gadoxetate disodium was successful in whole body staging of patients with neuroendocrine tumor. Gadoxetic acid 67-86 cell cycle regulator of NHEJ Homo sapiens 28-35 26076199-1 2015 PURPOSE: To investigate the utility of dynamic contrast-enhanced MRI (DCE-MRI) with Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for detecting liver fibrosis induced by carbon tetrachloride (CCl4) in rats. Gadoxetic acid 84-143 C-C motif chemokine ligand 4 Rattus norvegicus 220-224 25231411-11 2015 CONCLUSIONS: Although AMLs showed similar enhancement patterns to HCCs during the dynamic phases of gadoxetic acid-enhanced MRI, using characteristic MR features of AML during the HBP and demographic differences, one can better differentiate AML from HCC. Gadoxetic acid 100-114 holocytochrome c synthase Homo sapiens 66-70 25668519-11 2015 CONCLUSION: HCCs with beta-catenin mutation showed a higher grade of differentiation with frequent pseudoglandular patterns and bile production, and characteristic imaging findings included a high enhancement ratio at gadoxetic acid-enhanced MR imaging and a high apparent diffusion coefficient at diffusion-weighted imaging. Gadoxetic acid 218-232 holocytochrome c synthase Homo sapiens 12-16 25668519-11 2015 CONCLUSION: HCCs with beta-catenin mutation showed a higher grade of differentiation with frequent pseudoglandular patterns and bile production, and characteristic imaging findings included a high enhancement ratio at gadoxetic acid-enhanced MR imaging and a high apparent diffusion coefficient at diffusion-weighted imaging. Gadoxetic acid 218-232 catenin beta 1 Homo sapiens 22-34 25289480-1 2015 PURPOSE: To compare the value of enhancement and pharmacokinetic parameters measured at dynamic gadoxetate-enhanced magnetic resonance (MR) imaging in determining hepatic organic anion transporter expression in control rats and rats with advanced liver fibrosis. Gadoxetic acid 96-106 ATP binding cassette subfamily C member 3 Rattus norvegicus 171-196 25289480-10 2015 CONCLUSION: The pharmacokinetic parameter HEF at dynamic gadoxetate-enhanced MR imaging is independently correlated with hepatic organic anion transporter expression. Gadoxetic acid 57-67 ATP binding cassette subfamily C member 3 Rattus norvegicus 129-154 25262955-1 2014 RATIONALE AND OBJECTIVES: To determine the accuracy of magnetic resonance imaging (MRI) with gadoxetic acid disodium for the detection of hepatocellular carcinoma (HCC). Gadoxetic acid 93-116 HCC Homo sapiens 164-167 25203131-0 2015 Diagnostic performance of gadoxetic acid-enhanced liver MR imaging in the detection of HCCs and allocation of transplant recipients on the basis of the Milan criteria and UNOS guidelines: correlation with histopathologic findings. Gadoxetic acid 26-40 holocytochrome c synthase Homo sapiens 87-91 25262955-11 2014 CONCLUSIONS: MRI with gadoxetic acid disodium is a noninvasive and no radiation exposure imaging modality with high sensitivity and specificity for the detection of HCC. Gadoxetic acid 22-45 HCC Homo sapiens 165-168 24946283-0 2014 OATP1B3 expression is strongly associated with Wnt/beta-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma. Gadoxetic acid 109-123 solute carrier organic anion transporter family member 1B3 Homo sapiens 0-7 24700365-2 2014 Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions with regard to vascularity and the activity of the organic anion transporter OATP1B3. Gadoxetic acid 0-59 solute carrier organic anion transporter family member 1B3 Homo sapiens 250-257 24700365-2 2014 Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) has been introduced recently to evaluate hepatic lesions with regard to vascularity and the activity of the organic anion transporter OATP1B3. Gadoxetic acid 61-72 solute carrier organic anion transporter family member 1B3 Homo sapiens 250-257 24700365-6 2014 By contrast, HCC showing reduced Gd-EOB-DTPA uptake with high serum AFP levels was associated with poor prognosis and the activation of the oncogene FOXM1. Gadoxetic acid 33-44 alpha fetoprotein Homo sapiens 68-71 24700365-6 2014 By contrast, HCC showing reduced Gd-EOB-DTPA uptake with high serum AFP levels was associated with poor prognosis and the activation of the oncogene FOXM1. Gadoxetic acid 33-44 forkhead box M1 Homo sapiens 149-154 24700365-7 2014 Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo. Gadoxetic acid 40-51 hepatocyte nuclear factor 4 alpha Homo sapiens 13-18 24700365-7 2014 Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo. Gadoxetic acid 40-51 alpha fetoprotein Homo sapiens 99-102 24700365-7 2014 Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo. Gadoxetic acid 40-51 forkhead box M1 Homo sapiens 107-112 24700365-7 2014 Knockdown of HNF4A in HCC cells showing Gd-EOB-DTPA uptake resulted in the increased expression of AFP and FOXM1 and the loss of OATP1B3 expression accompanied by morphological changes, enhanced tumorigenesis, and loss of Gd-EOB-DTPA uptake in vivo. Gadoxetic acid 222-233 hepatocyte nuclear factor 4 alpha Homo sapiens 13-18 23903870-4 2014 Uptakes of Sonazoid and Gd-EOB-DTPA were assessed by Sonazoid enhancement index and EOB enhancement ratio in relation to immunohistochemistry of CD68 and organic anion transporting polypeptide 8 (OATP8), respectively. Gadoxetic acid 24-35 solute carrier organic anion transporter family member 1B3 Homo sapiens 154-194 24666574-13 2014 CONCLUSIONS: Gd-EOB-DTPA-enhanced MRI described RLI as a decreased uptake of Gd-EOB-DTPA matching the irradiated area. Gadoxetic acid 13-24 ATP binding cassette subfamily E member 1 Homo sapiens 48-51 24666574-13 2014 CONCLUSIONS: Gd-EOB-DTPA-enhanced MRI described RLI as a decreased uptake of Gd-EOB-DTPA matching the irradiated area. Gadoxetic acid 77-88 ATP binding cassette subfamily E member 1 Homo sapiens 48-51 24380639-0 2014 Gd-EOB-DTPA enhanced MRI of the liver: correlation of relative hepatic enhancement, relative renal enhancement, and liver to kidneys enhancement ratio with serum hepatic enzyme levels and eGFR. Gadoxetic acid 0-11 epidermal growth factor receptor Homo sapiens 188-192 24297598-1 2014 PURPOSE: The aim of our study was to evaluate the diagnostic accuracy of gadoxetic acid-enhanced magnetic resonance (MR) imaging both in the detection of hepatocellular carcinoma (HCC) and precancerous lesions and in the assessment of their evolution. Gadoxetic acid 73-87 HCC Homo sapiens 180-183 24297598-10 2014 CONCLUSIONS: Gadoxetic acid-enhanced MR imaging is useful for detecting HCC as well as hypovascular nodules with potential progression to HCC. Gadoxetic acid 13-27 HCC Homo sapiens 72-75 24297598-10 2014 CONCLUSIONS: Gadoxetic acid-enhanced MR imaging is useful for detecting HCC as well as hypovascular nodules with potential progression to HCC. Gadoxetic acid 13-27 HCC Homo sapiens 138-141 24806238-1 2014 We report three cases of resected hepatocellular carcinomas with nodules showing different signal intensities in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MRI (EOB-MRI). Gadoxetic acid 140-199 cell cycle regulator of NHEJ Homo sapiens 214-221 23884757-2 2013 AIM: We performed a meta-analysis of all available studies of the diagnostic performance of gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for detection of HCC in patients with chronic liver disease. Gadoxetic acid 92-106 cell cycle regulator of NHEJ Homo sapiens 121-131 24289722-7 2013 RESULTS: Diagnostic accuracy was significantly improved by the addition of Gd-EOB-DTPA-enhanced dynamic images: Az in set 1 was 0.708 and 0.833 in set 2 (P = 0.0002). Gadoxetic acid 75-86 SET domain containing 1A, histone lysine methyltransferase Homo sapiens 118-123 24289722-7 2013 RESULTS: Diagnostic accuracy was significantly improved by the addition of Gd-EOB-DTPA-enhanced dynamic images: Az in set 1 was 0.708 and 0.833 in set 2 (P = 0.0002). Gadoxetic acid 75-86 SET domain containing 2, histone lysine methyltransferase Homo sapiens 147-152 24114823-1 2013 INTRODUCTION: Gadoxetate-disodium is a liver-specific MR contrast agent absorbed by hepatocytes via organic anion transporting polypeptide 1B3 and is excreted into the biliary system by multidrug resistance-associated protein 2. Gadoxetic acid 14-33 ATP binding cassette subfamily C member 2 Homo sapiens 186-227 22911100-1 2012 We report a male case of beta-catenin-activated hepatocellular adenoma (HCA) focusing on findings of gadoxetic-acid-enhanced magnetic resonance imaging (EOB-MRI) and discussing the molecular background and possible clinical significance. Gadoxetic acid 101-115 catenin beta 1 Homo sapiens 25-37 23401584-9 2013 CONCLUSION: HCCs can be classified into several imaging patterns on gadoxetic acid-enhanced MR images, which are associated with tumor aggressiveness and outcome. Gadoxetic acid 68-82 holocytochrome c synthase Homo sapiens 12-16 23442774-0 2013 Dynamic contrast-enhanced MRI of the liver in Mrp2-deficient rats using the hepatobiliary contrast agent Gd-EOB-DTPA. Gadoxetic acid 105-116 ATP binding cassette subfamily C member 2 Rattus norvegicus 46-50 23442774-8 2013 RESULTS: The relative enhancement of the Mrp2-deficient, Eisai hyperbilirubinuria rats (EHBRs) (48.6% [3.4%]) was significantly lower than that of the control rats (64.0% [3.2%]; P < 0.001) 5 minutes after the Gd-EOB-DTPA injection. Gadoxetic acid 213-224 ATP binding cassette subfamily C member 2 Rattus norvegicus 41-45 22771883-1 2012 PURPOSE: To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects. Gadoxetic acid 162-176 solute carrier organic anion transporter family member 1B1 Homo sapiens 71-120 22847903-1 2012 BACKGROUND: As gadoxetic acid-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) have been widely used for the evaluation of hepatocellular carcinoma (HCC), it is clinically relevant to determine the diagnostic efficacy of gadoxetic acid-enhanced MRI and DWI for detection of HCCs with respect to the severity of liver cirrhosis. Gadoxetic acid 15-29 holocytochrome c synthase Homo sapiens 304-308 22847903-2 2012 PURPOSE: To compare the diagnostic accuracy and sensitivity of gadoxetic acid-enhanced MRI and DWI for detection of HCCs with respect to the severity of liver cirrhosis. Gadoxetic acid 63-77 holocytochrome c synthase Homo sapiens 116-120 22771883-1 2012 PURPOSE: To determine if genetic polymorphisms of liver-specific human organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 influence cellular uptake of gadoxetic acid in vitro and if functionally relevant polymorphisms are confounders for liver enhancement by gadoxetic acid in healthy subjects. Gadoxetic acid 162-176 solute carrier organic anion transporter family member 1B3 Homo sapiens 125-132 22771883-3 2012 Cellular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured by using stable transfected embryonic kidney HEK293 cells. Gadoxetic acid 19-33 solute carrier organic anion transporter family member 1B1 Homo sapiens 37-44 22771883-3 2012 Cellular uptake of gadoxetic acid by OATP1B1 and OATP1B3 and their frequent genetic variants was measured by using stable transfected embryonic kidney HEK293 cells. Gadoxetic acid 19-33 solute carrier organic anion transporter family member 1B3 Homo sapiens 49-56 22771883-7 2012 Liver enhancement with gadoxetic acid was reduced in subjects with OATP1B1*1a/*5 compared with wild-type subjects and those with OATP1B1*1b/*1b (area under enhancement curve, 3-480 minutes in arbitrary units [au]; 20.7 au +- 6.85 vs 36.5 au +- 8.08 [P = .006] vs 34.6 au +- 8.92 [P = .026]). Gadoxetic acid 23-37 solute carrier organic anion transporter family member 1B1 Homo sapiens 67-74 22771883-10 2012 CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjects. Gadoxetic acid 71-85 solute carrier organic anion transporter family member 1B1 Homo sapiens 27-34 22771883-10 2012 CONCLUSION: Liver-specific OATP1B1 and OATP1B3 are uptake carriers for gadoxetic acid in subjects. Gadoxetic acid 71-85 solute carrier organic anion transporter family member 1B3 Homo sapiens 39-46 22771883-11 2012 Genetic polymorphisms of OATP1B1 are signal confounders in gadoxetic acid-enhanced liver MR imaging. Gadoxetic acid 59-73 solute carrier organic anion transporter family member 1B1 Homo sapiens 25-32 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 72-86 solute carrier organic anion transporter family member 1B3 Homo sapiens 155-160 22391331-8 2012 The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1. Gadoxetic acid 57-67 solute carrier organic anion transporter family member 1B1 Homo sapiens 98-105 22391331-8 2012 The developed assay was successfully applied to quantify gadoxetate in cellular uptake studies in OATP1B1-transfected cell lines and to monitor serum concentrations-time profiles from a clinical pilot study performed in healthy volunteers carrying the wild-type or the functionally relevant variants T521C (*5) and A388G (*1b) of the hepatic uptake transporter OATP1B1. Gadoxetic acid 57-67 solute carrier organic anion transporter family member 1B1 Homo sapiens 361-368 21691816-1 2011 The organic anion transporter peptides (OATP) 1B1 and 1B3 are hepatocytic-specific transporters determinant for the uptake of the contrast media Gd-EOB-DTPA during magnetic resonance, but variably lost in hepatocellular carcinoma (HCC). Gadoxetic acid 145-156 solute carrier organic anion transporter family member 1B1 Homo sapiens 4-57 21606265-0 2011 Hypervascular hepatocellular carcinoma 1 cm or smaller in patients with chronic liver disease: characterization with gadoxetic acid-enhanced MRI that includes diffusion-weighted imaging. Gadoxetic acid 117-131 SAP domain containing ribonucleoprotein Homo sapiens 14-40 21628934-6 2011 Immunohistochemical analysis revealed a markedly reduced expression of organic anion transporter (OATP) 1B3 in this nodule, which implied decreased Gd-EOB-DTPA uptake by hepatocytes and accounted for the low signal intensity during the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI. Gadoxetic acid 148-159 solute carrier organic anion transporter family member 1B3 Homo sapiens 71-107 21628934-6 2011 Immunohistochemical analysis revealed a markedly reduced expression of organic anion transporter (OATP) 1B3 in this nodule, which implied decreased Gd-EOB-DTPA uptake by hepatocytes and accounted for the low signal intensity during the hepatobiliary phase on Gd-EOB-DTPA-enhanced MRI. Gadoxetic acid 259-270 solute carrier organic anion transporter family member 1B3 Homo sapiens 71-107 20698804-11 2010 CONCLUSION: The contrast enhancement after gadoxetic acid is comparable to Gd-DTPA and appears suitable for comprehensive TNM-staging by combining high accurate liver-specific phases with efficacious vascular enhancement in the different anatomic regions. Gadoxetic acid 43-57 teneurin transmembrane protein 1 Homo sapiens 122-125 22504332-3 2012 The hepatocyte uptake of Gd-EOB-DTPA mainly occurs via the organic anion transporter polypeptides OATP1B1 and B3 located at the sinusoidal membrane and biliary excretion via the multidrug resistance-associated proteins MRP2 at the canalicular membrane. Gadoxetic acid 25-36 solute carrier organic anion transporter family member 1B1 Homo sapiens 98-105 22504332-3 2012 The hepatocyte uptake of Gd-EOB-DTPA mainly occurs via the organic anion transporter polypeptides OATP1B1 and B3 located at the sinusoidal membrane and biliary excretion via the multidrug resistance-associated proteins MRP2 at the canalicular membrane. Gadoxetic acid 25-36 ATP binding cassette subfamily C member 2 Homo sapiens 219-223 22270142-8 2012 CONCLUSION: Contrast-enhanced ultrasound yields a significantly higher AUC value than gadoxetate disodium-enhanced MR imaging in the assessment of arterial hypervascularity of HCC and DN. Gadoxetic acid 86-105 HCC Homo sapiens 176-179 21920517-1 2012 AIM: To compare the diagnostic performances of gadoxetic acid-enhanced magnetic resonance imaging (MRI) and multiphasic multidetector computed tomography (MDCT) in the detection of hepatocellular carcinoma (HCC) in patients with chronic liver disease. Gadoxetic acid 47-61 HCC Homo sapiens 207-210 21920517-11 2012 CONCLUSION: Gadoxetic acid-enhanced MRI and MDCT show similar diagnostic performances for the detection of HCC in patients with chronic liver disease. Gadoxetic acid 12-26 HCC Homo sapiens 107-110 21626360-0 2011 The uptake transporter OATP8 expression decreases during multistep hepatocarcinogenesis: correlation with gadoxetic acid enhanced MR imaging. Gadoxetic acid 106-120 solute carrier organic anion transporter family member 1B3 Homo sapiens 23-28 21626360-1 2011 OBJECTIVES: To clarify the changes in organic anion-transporting polypeptide 8 (OATP8) expression and enhancement ratio on gadoxetic acid-enhanced MR imaging in hepatocellular nodules during multistep hepatocarcinogenesis. Gadoxetic acid 123-137 solute carrier organic anion transporter family member 1B3 Homo sapiens 80-85 21626360-8 2011 CONCLUSIONS: The immunohistochemical expression of OATP8 significantly decreases during multistep hepatocarcinogenesis, which may explain the decrease in enhancement ratio on gadoxetic acid-enhanced MR imaging. Gadoxetic acid 175-189 solute carrier organic anion transporter family member 1B3 Homo sapiens 51-56 21928003-0 2011 Usefulness of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance cholangiography for detecting mucin retention in bile ducts: a rare intraductal papillary mucinous neoplasm of the bile duct. Gadoxetic acid 14-73 LOC100508689 Homo sapiens 132-137 21928003-4 2011 We describe a rare case of IPMN-B in which gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance cholangiography was useful for detecting mucin retention in the bile ducts. Gadoxetic acid 43-102 LOC100508689 Homo sapiens 172-177 19545960-7 2010 Additionally, Gd-EOB-DTPA-enhanced MR may delineate mucin as a filling defect surrounding hyperintense bile. Gadoxetic acid 14-25 LOC100508689 Homo sapiens 52-57 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 72-86 ATP binding cassette subfamily C member 3 Homo sapiens 165-169 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 72-86 solute carrier organic anion transporter family member 1B3 Homo sapiens 217-222 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 72-86 ATP binding cassette subfamily C member 3 Homo sapiens 239-243 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 187-201 solute carrier organic anion transporter family member 1B3 Homo sapiens 155-160 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 187-201 ATP binding cassette subfamily C member 3 Homo sapiens 165-169 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 187-201 solute carrier organic anion transporter family member 1B3 Homo sapiens 217-222 20663969-11 2010 CONCLUSION: The enhancement ratio of HCCs in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging positively correlated with expression levels of OATP8 and MRP3, indicating that gadoxetic acid is taken up by OATP8 and excreted by MRP3. Gadoxetic acid 187-201 ATP binding cassette subfamily C member 3 Homo sapiens 239-243 20663976-12 2010 CONCLUSION: Findings showed that liver cirrhosis promotes the elimination of gadoxetic acid mediated by mrp2; therefore, mrp2 up-regulation may explain the significant signal intensity loss noted on gadoxetic acid-enhanced MR images in the rat. Gadoxetic acid 77-91 ATP binding cassette subfamily C member 2 Rattus norvegicus 104-108 20663976-12 2010 CONCLUSION: Findings showed that liver cirrhosis promotes the elimination of gadoxetic acid mediated by mrp2; therefore, mrp2 up-regulation may explain the significant signal intensity loss noted on gadoxetic acid-enhanced MR images in the rat. Gadoxetic acid 77-91 ATP binding cassette subfamily C member 2 Rattus norvegicus 121-125 20663976-12 2010 CONCLUSION: Findings showed that liver cirrhosis promotes the elimination of gadoxetic acid mediated by mrp2; therefore, mrp2 up-regulation may explain the significant signal intensity loss noted on gadoxetic acid-enhanced MR images in the rat. Gadoxetic acid 199-213 ATP binding cassette subfamily C member 2 Rattus norvegicus 121-125 20380933-7 2010 Four HCCs were clearly revealed as hypointense only on gadoxetic acid-enhanced hepatocyte phase imaging, but were occult on other sequences, including the SPIO set. Gadoxetic acid 55-69 holocytochrome c synthase Homo sapiens 5-9 20714357-5 2010 The transport of gadoxetic acid from the cytoplasm to the bile is mainly determined by the capacity of the transport protein glutathione-S-transferase. Gadoxetic acid 17-31 glutathione S-transferase kappa 1 Homo sapiens 125-150 20406852-4 2010 In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM). Gadoxetic acid 23-34 solute carrier organic anion transporter family member 1B1 Homo sapiens 88-95 20406852-4 2010 In competition assays, Gd-EOB-DTPA inhibited the uptake of bromosulfophthalein (BSP) by OATP1B1 (IC(50) = 0.6 mM) and OATP1B3 (IC(50) = 0.4 mM). Gadoxetic acid 23-34 solute carrier organic anion transporter family member 1B3 Homo sapiens 118-125 20406852-9 2010 In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP. Gadoxetic acid 15-26 solute carrier organic anion transporter family member 1B1 Homo sapiens 64-71 20406852-9 2010 In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP. Gadoxetic acid 15-26 solute carrier organic anion transporter family member 1B3 Homo sapiens 73-80 20406852-9 2010 In conclusion, Gd-EOB-DTPA is a substrate of the liver-specific OATP1B1, OATP1B3, and NTCP. Gadoxetic acid 15-26 solute carrier family 10 member 1 Homo sapiens 86-90 20661702-1 2010 The purpose of this report was to describe pseudolesions of the liver that mimicked residual hypervascular hepatocellular carcinoma (HCC), as observed on gadoxetate disodium-enhanced magnetic resonance imaging (EOB-MRI) obtained shortly after transarterial chemoembolization (TACE). Gadoxetic acid 154-173 HCC Homo sapiens 133-136 20661702-3 2010 In all three patients, nontumorous liver tissue adjacent to the treated HCC exhibited focal arterial enhancement on dynamic phase and subsequent diminished uptake of gadoxetate disodium on hepatocellular phase images, which mimicked residual HCC. Gadoxetic acid 166-185 HCC Homo sapiens 72-75 20380933-8 2010 CONCLUSION: Gadoxetic acid-enhanced MRI is better than SPIO-enhanced MRI for the detection of HCCs. Gadoxetic acid 12-26 holocytochrome c synthase Homo sapiens 94-98 19484243-1 2009 The purpose of this study was to perform an economic evaluation of hepatocyte-specific Gd-EOB-DTPA enhanced MRI (PV-MRI) compared to extracellular contrast-media-enhanced MRI (ECCM-MRI) and three-phase-MDCT as initial modalities in the work-up of patients with metachronous colorectal liver metastases. Gadoxetic acid 87-98 cell cycle regulator of NHEJ Homo sapiens 113-119 19404564-0 2009 Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. Gadoxetic acid 43-54 solute carrier organic anion transporter family member 1B3 Homo sapiens 14-21 19404564-8 2009 HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001). Gadoxetic acid 10-21 solute carrier organic anion transporter family member 1B3 Homo sapiens 43-50 19404564-8 2009 HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs (r=0.91, P<0.0001). Gadoxetic acid 10-21 solute carrier organic anion transporter family member 1B3 Homo sapiens 102-109 19404564-9 2009 CONCLUSIONS: Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production. Gadoxetic acid 23-34 solute carrier organic anion transporter family member 1B3 Homo sapiens 73-80 18058865-3 2007 The interaction of three gadolinium contrast agents (Gd-EOB-DTPA, Gd-BOPTA and MP-2269) with human serum albumin was assessed through the measurement of proton relaxation rate enhancement in various experimental conditions. Gadoxetic acid 53-64 albumin Homo sapiens 99-112