PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33892113-7	2021	Furthermore, activation of Nrf2 by sulforaphane diminishes, whereas inhibition of Nrf2 by ML385 enhances IR-induced killing of TNBC CSCs.	sulforaphane	35-47	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
33894213-0	2021	Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1alpha/Nrf2 pathway and autophagy in retinal pigment epithelial cells.	sulforaphane	0-12	sirtuin 1	Homo sapiens	88-93
33894213-0	2021	Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1alpha/Nrf2 pathway and autophagy in retinal pigment epithelial cells.	sulforaphane	0-12	PPARG coactivator 1 alpha	Homo sapiens	94-104
33894213-0	2021	Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1alpha/Nrf2 pathway and autophagy in retinal pigment epithelial cells.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
33894213-4	2021	The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN.	sulforaphane	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
33894213-4	2021	The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN.	sulforaphane	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
33894213-4	2021	The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN.	sulforaphane	119-122	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
33894213-4	2021	The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN.	sulforaphane	119-122	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
33894213-4	2021	The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN.	sulforaphane	119-122	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
33894213-4	2021	The protective effect of SFN on blue light-induced injury was blocked by the Nrf2 inhibitor ML385, suggesting that the SFN-induced Nrf2 pathway is involved in the cytoprotective effect of SFN.	sulforaphane	119-122	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
31409554-1	2021	BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) and the serine/threonine protein kinase mechanistic target of rapamycin (mTOR).	sulforaphane	45-48	NFE2 like bZIP transcription factor 2	Homo sapiens	315-319
31409554-1	2021	BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) and the serine/threonine protein kinase mechanistic target of rapamycin (mTOR).	sulforaphane	45-48	mechanistic target of rapamycin kinase	Homo sapiens	361-392
31409554-1	2021	BACKGROUND: The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of cellular homeostasis, among which are those regulated by the stress response transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) and the serine/threonine protein kinase mechanistic target of rapamycin (mTOR).	sulforaphane	45-48	mechanistic target of rapamycin kinase	Homo sapiens	394-398
31409554-2	2021	Whereas the way by which SFN activates NRF2 is well established, the molecular mechanism(s) of how SFN inhibits mTOR is not understood.	sulforaphane	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
31409554-2	2021	Whereas the way by which SFN activates NRF2 is well established, the molecular mechanism(s) of how SFN inhibits mTOR is not understood.	sulforaphane	99-102	mechanistic target of rapamycin kinase	Homo sapiens	112-116
31409554-5	2021	The phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B (PKB) is a positive regulator of mTOR, and treatment with SFN caused an increase in the phosphorylation of AKT at T308 and S473, two phosphorylation sites associated with AKT activation.	sulforaphane	120-123	AKT serine/threonine kinase 1	Homo sapiens	41-44
31409554-5	2021	The phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B (PKB) is a positive regulator of mTOR, and treatment with SFN caused an increase in the phosphorylation of AKT at T308 and S473, two phosphorylation sites associated with AKT activation.	sulforaphane	120-123	AKT serine/threonine kinase 1	Homo sapiens	63-66
31409554-5	2021	The phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B (PKB) is a positive regulator of mTOR, and treatment with SFN caused an increase in the phosphorylation of AKT at T308 and S473, two phosphorylation sites associated with AKT activation.	sulforaphane	120-123	mechanistic target of rapamycin kinase	Homo sapiens	95-99
31409554-5	2021	The phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B (PKB) is a positive regulator of mTOR, and treatment with SFN caused an increase in the phosphorylation of AKT at T308 and S473, two phosphorylation sites associated with AKT activation.	sulforaphane	120-123	AKT serine/threonine kinase 1	Homo sapiens	169-172
31409554-5	2021	The phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B (PKB) is a positive regulator of mTOR, and treatment with SFN caused an increase in the phosphorylation of AKT at T308 and S473, two phosphorylation sites associated with AKT activation.	sulforaphane	120-123	AKT serine/threonine kinase 1	Homo sapiens	169-172
31409554-7	2021	In addition, SFN inhibited the activity of the cytoplasmic histone deacetylase 6 (HDAC6), the inhibition of which has been reported to promote the acetylation and decreases the kinase activity of AKT.	sulforaphane	13-16	histone deacetylase 6	Homo sapiens	59-80
31409554-7	2021	In addition, SFN inhibited the activity of the cytoplasmic histone deacetylase 6 (HDAC6), the inhibition of which has been reported to promote the acetylation and decreases the kinase activity of AKT.	sulforaphane	13-16	histone deacetylase 6	Homo sapiens	82-87
31409554-7	2021	In addition, SFN inhibited the activity of the cytoplasmic histone deacetylase 6 (HDAC6), the inhibition of which has been reported to promote the acetylation and decreases the kinase activity of AKT.	sulforaphane	13-16	AKT serine/threonine kinase 1	Homo sapiens	196-199
33966346-0	2021	Investigating binding tendency, stability of Sulforaphane-N-acetyl cysteine in the active site of histone deacetylase 2 (HDAC2) and testing its cytotoxicity against distinct cancer lines through stringent molecular dynamics, DFT and cell based assays.	sulforaphane	45-57	histone deacetylase 2	Homo sapiens	98-119
34024870-6	2021	Sulforaphane and auranofin, activators of Nrf2 that is a master regulator of anti-oxidative response, did not affect U46619-evoked edema but almost abolished TCDD-induced edema and potentiation by paraquat in both TCDD- and U46619-induced edema.	sulforaphane	0-12	nfe2 like bZIP transcription factor 2a	Danio rerio	42-46
33966346-0	2021	Investigating binding tendency, stability of Sulforaphane-N-acetyl cysteine in the active site of histone deacetylase 2 (HDAC2) and testing its cytotoxicity against distinct cancer lines through stringent molecular dynamics, DFT and cell based assays.	sulforaphane	45-57	histone deacetylase 2	Homo sapiens	121-126
33966346-4	2021	Sulforaphane-N-acetylcysteine (SFN-N-acetylcysteine or SFN-NAC), a sulforaphane metabolite has shown significantly superior activity against HDACs under in vitro conditions.	sulforaphane	67-79	RNA exonuclease 2	Homo sapiens	31-34
33966346-4	2021	Sulforaphane-N-acetylcysteine (SFN-N-acetylcysteine or SFN-NAC), a sulforaphane metabolite has shown significantly superior activity against HDACs under in vitro conditions.	sulforaphane	67-79	RNA exonuclease 2	Homo sapiens	55-58
33966346-4	2021	Sulforaphane-N-acetylcysteine (SFN-N-acetylcysteine or SFN-NAC), a sulforaphane metabolite has shown significantly superior activity against HDACs under in vitro conditions.	sulforaphane	67-79	synuclein alpha	Homo sapiens	59-62
33711331-0	2021	Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNAs alteration.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	22-27
34033999-0	2021	Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein.	sulforaphane	0-12	interleukin 6	Homo sapiens	40-53
34033999-0	2021	Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein.	sulforaphane	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	58-71
34033999-0	2021	Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein.	sulforaphane	0-12	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	146-151
33711331-0	2021	Sulforaphane inhibits NLRP3 inflammasome activation in microglia through Nrf2-mediated miRNAs alteration.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	43-55	NLR family, pyrin domain containing 3	Mus musculus	99-104
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	43-55	interleukin 1 alpha	Mus musculus	127-135
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	43-55	interleukin 18	Mus musculus	140-145
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	57-60	NLR family, pyrin domain containing 3	Mus musculus	99-104
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	57-60	interleukin 1 alpha	Mus musculus	127-135
33711331-3	2021	In the current study, we demonstrated that Sulforaphane (SFN), a dietary natural product, inhibits NLRP3 inflammasome mediated IL-1beta and IL-18 secretion and pyroptosis in murine microglial cells.	sulforaphane	57-60	interleukin 18	Mus musculus	140-145
33711331-6	2021	SFN also prevented caspase-1 dependent pyroptotic cell death in microglia.	sulforaphane	0-3	caspase 1	Mus musculus	19-28
33929090-0	2021	Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).	sulforaphane	0-12	sarcoglycan gamma	Homo sapiens	102-105
33793066-0	2021	Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 through epigenetic modification.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
33929090-5	2021	SFN reversed the increase of Ca2+ induced by fatty acid and inhibited the Ca2+ channel IP3R.	sulforaphane	0-3	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	87-91
33996874-2	2021	Sulforaphane, in turn, is an inducer of cytoprotective enzymes through activation of Nrf2 signaling, and a potent inhibitor of carcinogenesis in multiple murine models.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
33741493-1	2021	The phytochemical sulforaphane (SF) has gained interest for its apparent association with reduced cancer risk and other cytoprotective properties, at least some of which are attributed to activation of the transcription factor Nrf2.	sulforaphane	18-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	227-231
33741493-1	2021	The phytochemical sulforaphane (SF) has gained interest for its apparent association with reduced cancer risk and other cytoprotective properties, at least some of which are attributed to activation of the transcription factor Nrf2.	sulforaphane	32-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	227-231
33996874-3	2021	Sulforaphane is also protective in models of diabetes, neurodegenerative disease, and other inflammatory processes, likely reflecting additional actions of Nrf2 and interactions with other signaling pathways.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	156-160
33927630-12	2021	The possible interventions by curcumin, resveratrol, cannabidiol, ginsenosides, flavonoids and sulforaphane on microglia specific protein Iba1 suggest possibility of natural products mediated regulation of microglia phenotypes and its functions to control redox imbalance and neuroinflammation in management of Alzheimer"s, Parkinson"s and Multiple Sclerosis for microglia-mediated therapeutics.	sulforaphane	95-107	allograft inflammatory factor 1	Homo sapiens	138-142
33901343-6	2022	Moreover, BOE, glucosinlates and sulforaphane can up-regulate the cytokeratin gene expression in HaCaT cells, prevent the increase in Bax gene levels induced by testosterone in DP and promote the growth of hair follicle of mice.	sulforaphane	33-45	BCL2 associated X, apoptosis regulator	Homo sapiens	134-137
33899586-9	2021	Interestingly; the over expression of Nrf2 using Nrf2-Ad-WT or Sulforaphane was also associated with significant upregulation of IL-8 compared to controls.	sulforaphane	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33899586-9	2021	Interestingly; the over expression of Nrf2 using Nrf2-Ad-WT or Sulforaphane was also associated with significant upregulation of IL-8 compared to controls.	sulforaphane	63-75	C-X-C motif chemokine ligand 8	Homo sapiens	129-133
33930529-8	2021	The mechanistic role of MAPK in TCE-mediated autoimmunity was further established by treating MRL+/+ mice with sulforaphane (SFN; 8 mg/kg, i.p., every other day) along with TCE (10 mmol/kg, i.p., every 4th day) for 6 wks using an established protocol, and by in vitro treatment of T cells with dichloroacetyl chloride (a TCE metabolite) with/without p38 MAPK inhibitor.	sulforaphane	111-123	mitogen-activated protein kinase 14	Mus musculus	350-358
33930529-9	2021	SFN treatment attenuated the TCE-mediated phosphorylation of p38 MAPK.	sulforaphane	0-3	mitogen-activated protein kinase 14	Mus musculus	61-69
33872411-0	2021	Sulforaphane inhibits PRMT5 and MEP50 function to suppress the mesothelioma cancer cell phenotype.	sulforaphane	0-12	protein arginine methyltransferase 5	Homo sapiens	22-27
33872411-0	2021	Sulforaphane inhibits PRMT5 and MEP50 function to suppress the mesothelioma cancer cell phenotype.	sulforaphane	0-12	WD repeat domain 77	Homo sapiens	32-37
33872411-6	2021	Treatment with sulforaphane (SFN), a diet-derived anticancer agent, reduces PRMT5/MEP50 level and H4R3me2s formation and suppresses the cancer phenotype.	sulforaphane	15-27	protein arginine methyltransferase 5	Homo sapiens	76-81
33872411-6	2021	Treatment with sulforaphane (SFN), a diet-derived anticancer agent, reduces PRMT5/MEP50 level and H4R3me2s formation and suppresses the cancer phenotype.	sulforaphane	15-27	WD repeat domain 77	Homo sapiens	82-87
33872411-6	2021	Treatment with sulforaphane (SFN), a diet-derived anticancer agent, reduces PRMT5/MEP50 level and H4R3me2s formation and suppresses the cancer phenotype.	sulforaphane	29-32	protein arginine methyltransferase 5	Homo sapiens	76-81
33872411-6	2021	Treatment with sulforaphane (SFN), a diet-derived anticancer agent, reduces PRMT5/MEP50 level and H4R3me2s formation and suppresses the cancer phenotype.	sulforaphane	29-32	WD repeat domain 77	Homo sapiens	82-87
33872411-8	2021	SFN treatment also reduces tumor formation which is associated with reduced PRMT5/MEP50 expression and activity.	sulforaphane	0-3	protein arginine methyltransferase 5	Homo sapiens	76-81
33872411-8	2021	SFN treatment also reduces tumor formation which is associated with reduced PRMT5/MEP50 expression and activity.	sulforaphane	0-3	WD repeat domain 77	Homo sapiens	82-87
33735260-6	2021	Sulforaphane (SFA) derived from cruciferous vegetables such as broccoli sprouts (BrSps) is a phase-II enzyme inducer that acts via cytoplasmic Nrf2 to enhance the production of anti-oxidants in the brain through the glutathione pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
32138578-8	2021	Notably, TFEB activity is required for SFN-induced protection against both acute oxidant bursts and chronic oxidative stress.	sulforaphane	39-42	transcription factor EB	Bos taurus	9-13
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	heme oxygenase 1	Bos taurus	627-632
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	heme oxygenase 1	Bos taurus	633-637
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	kelch like ECH associated protein 1	Bos taurus	672-677
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	kelch like ECH associated protein 1	Bos taurus	679-714
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	lysosomal associated membrane protein 1	Bos taurus	730-735
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	lysosomal associated membrane protein 1	Bos taurus	737-776
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	mucolipin TRP cation channel 1	Bos taurus	778-784
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	mechanistic target of rapamycin kinase	Bos taurus	904-908
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	mechanistic target of rapamycin kinase	Bos taurus	910-948
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	NFE2 like bZIP transcription factor 2	Bos taurus	1031-1037
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	ribosomal protein S6 kinase B1	Bos taurus	1246-1253
34004418-7	2021	RESULTS: In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane.	sulforaphane	32-44	interleukin 6	Homo sapiens	196-209
34004418-7	2021	RESULTS: In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane.	sulforaphane	288-300	interleukin 6	Homo sapiens	196-209
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	ribosomal protein S6 kinase B1	Bos taurus	1254-1258
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	ribosomal protein S6 kinase B1	Bos taurus	1259-1265
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	ribosomal protein S6 kinase B1	Bos taurus	1267-1302
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	transcription factor EB	Bos taurus	1318-1322
32138578-9	2021	Hence, by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases.Abbreviations: ANOVA: analyzes of variance; AREs: antioxidant response elements; Baf-A1: bafilomycin A1; BHA: butylhydroxyanisole; CAT: catechin hydrate; CCCP: carbonyl cyanide m- chlorophenylhydrazone; CLEAR: coordinated lysosomal expression and regulation; DCFH-DA: 2",7"-dichlorofluorescin diacetate; FBS: fetal bovine serum; GFP: green fluorescent protein; HMOX1/HO-1: heme oxygenase 1; KD: knockdown; KEAP1: kelch like ECH associated protein 1; KO: knockout; LAMP1: lysosomal associated membrane protein 1; MCOLN1/TRPML1: mucolipin 1; ML-SA1: mucolipin-specific synthetic agonist 1; ML-SI3: mucolipin-specific synthetic inhibitor 3; MTOR: mechanistic target of rapamycin kinase; MTORC1: mechanistic target of rapamycin kinase complex 1; NAC: N-acetylcysteine; NFE2L2/NRF2: nuclear factor: erythroid 2 like 2; NPC: Niemann-Pick type C; PBS: phosphate-buffered saline; PPP2/PP2A: protein phosphatase 2; Q-PCR: real time polymerase chain reaction; ROS: reactive oxygen species; RPS6KB1/S6K1/p70S6K: ribosomal protein S6 kinase B1; SFN: sulforaphane; TFEB: transcription factor EB; WT, wild-type.	sulforaphane	104-107	transcription factor EB	Bos taurus	1324-1347
33392911-0	2021	The Isothiocyanate Sulforaphane Depends on the Nrf2/gamma-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
33735260-6	2021	Sulforaphane (SFA) derived from cruciferous vegetables such as broccoli sprouts (BrSps) is a phase-II enzyme inducer that acts via cytoplasmic Nrf2 to enhance the production of anti-oxidants in the brain through the glutathione pathway.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
33388347-0	2021	Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
32762135-8	2021	Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2.	sulforaphane	31-43	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
33488795-0	2021	Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR-34a/SIRT1 axis by upregulating nuclear factor erythroid-2-related factor 2.	sulforaphane	0-12	microRNA 34a	Homo sapiens	91-98
33488795-0	2021	Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR-34a/SIRT1 axis by upregulating nuclear factor erythroid-2-related factor 2.	sulforaphane	0-12	sirtuin 1	Homo sapiens	99-104
33488795-0	2021	Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR-34a/SIRT1 axis by upregulating nuclear factor erythroid-2-related factor 2.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	126-169
33388347-0	2021	Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway.	sulforaphane	0-12	toll-like receptor 4	Mus musculus	196-200
33388347-3	2021	Sulforaphane, a phytochemical found in cruciferous vegetables, activates nuclear factor erythroid 2-related factor 2 (Nrf2) and exerts anticancer, antidiabetic, and antimicrobial effects; however, few studies investigated its efficacy in the development of ALD-related fibrosis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	73-116
33388347-3	2021	Sulforaphane, a phytochemical found in cruciferous vegetables, activates nuclear factor erythroid 2-related factor 2 (Nrf2) and exerts anticancer, antidiabetic, and antimicrobial effects; however, few studies investigated its efficacy in the development of ALD-related fibrosis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
33388347-5	2021	Sulforaphane treatment induced the activity of acetaldehyde-metabolizing mitochondrial aldehyde dehydrogenase (ALDH2) in HepaRG cells and suppressed the acetaldehyde-induced proliferation and profibrogenic activity in LX-2 cells with upregulation of Nrf2-regulated antioxidant genes, including HMOX1, NQO1, and GSTM3.	sulforaphane	0-12	aldehyde dehydrogenase 2 family member	Homo sapiens	111-116
33388347-5	2021	Sulforaphane treatment induced the activity of acetaldehyde-metabolizing mitochondrial aldehyde dehydrogenase (ALDH2) in HepaRG cells and suppressed the acetaldehyde-induced proliferation and profibrogenic activity in LX-2 cells with upregulation of Nrf2-regulated antioxidant genes, including HMOX1, NQO1, and GSTM3.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	250-254
33388347-5	2021	Sulforaphane treatment induced the activity of acetaldehyde-metabolizing mitochondrial aldehyde dehydrogenase (ALDH2) in HepaRG cells and suppressed the acetaldehyde-induced proliferation and profibrogenic activity in LX-2 cells with upregulation of Nrf2-regulated antioxidant genes, including HMOX1, NQO1, and GSTM3.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	294-299
33388347-5	2021	Sulforaphane treatment induced the activity of acetaldehyde-metabolizing mitochondrial aldehyde dehydrogenase (ALDH2) in HepaRG cells and suppressed the acetaldehyde-induced proliferation and profibrogenic activity in LX-2 cells with upregulation of Nrf2-regulated antioxidant genes, including HMOX1, NQO1, and GSTM3.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	301-305
33388347-5	2021	Sulforaphane treatment induced the activity of acetaldehyde-metabolizing mitochondrial aldehyde dehydrogenase (ALDH2) in HepaRG cells and suppressed the acetaldehyde-induced proliferation and profibrogenic activity in LX-2 cells with upregulation of Nrf2-regulated antioxidant genes, including HMOX1, NQO1, and GSTM3.	sulforaphane	0-12	glutathione S-transferase mu 3	Homo sapiens	311-316
33388347-6	2021	Moreover, sulforaphane attenuated the LPS/toll-like receptor 4 (TLR4)-mediated sensitization to transforming growth factor-beta with downregulation of NADPH oxidase 1 (NOX1) and NOX4.	sulforaphane	10-22	toll like receptor 4	Homo sapiens	38-62
33388347-6	2021	Moreover, sulforaphane attenuated the LPS/toll-like receptor 4 (TLR4)-mediated sensitization to transforming growth factor-beta with downregulation of NADPH oxidase 1 (NOX1) and NOX4.	sulforaphane	10-22	toll like receptor 4	Homo sapiens	64-68
33388347-6	2021	Moreover, sulforaphane attenuated the LPS/toll-like receptor 4 (TLR4)-mediated sensitization to transforming growth factor-beta with downregulation of NADPH oxidase 1 (NOX1) and NOX4.	sulforaphane	10-22	tumor necrosis factor	Homo sapiens	96-127
33388347-6	2021	Moreover, sulforaphane attenuated the LPS/toll-like receptor 4 (TLR4)-mediated sensitization to transforming growth factor-beta with downregulation of NADPH oxidase 1 (NOX1) and NOX4.	sulforaphane	10-22	NADPH oxidase 1	Homo sapiens	151-166
33388347-6	2021	Moreover, sulforaphane attenuated the LPS/toll-like receptor 4 (TLR4)-mediated sensitization to transforming growth factor-beta with downregulation of NADPH oxidase 1 (NOX1) and NOX4.	sulforaphane	10-22	NADPH oxidase 1	Homo sapiens	168-172
33388347-6	2021	Moreover, sulforaphane attenuated the LPS/toll-like receptor 4 (TLR4)-mediated sensitization to transforming growth factor-beta with downregulation of NADPH oxidase 1 (NOX1) and NOX4.	sulforaphane	10-22	NADPH oxidase 4	Homo sapiens	178-182
33388347-8	2021	Additionally, sulforaphane significantly inhibited Kupffer cell infiltration and fibrosis, decreased fat accumulation and lipid peroxidation, and induced Nrf2-regulated antioxidant response genes in EtOH/CCl4-treated mice.	sulforaphane	14-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
33388347-9	2021	Furthermore, sulforaphane treatment blunted hepatic exposure of gut-derived LPS and suppressed hepatic TLR4 signaling pathway.	sulforaphane	13-25	toll like receptor 4	Homo sapiens	103-107
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	22-34	histone deacetylase 2	Mus musculus	190-195
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	22-34	transcriptional regulator, SIN3A (yeast)	Mus musculus	197-203
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	22-34	brain derived neurotrophic factor	Mus musculus	110-114
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	22-34	methyl CpG binding protein 2	Mus musculus	209-214
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	36-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	36-39	brain derived neurotrophic factor	Mus musculus	110-114
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	36-39	histone deacetylase 2	Mus musculus	190-195
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	36-39	transcriptional regulator, SIN3A (yeast)	Mus musculus	197-203
33627628-6	2021	Activation of Nrf2 by sulforaphane (SFN) showed fast-acting antidepressant-like effects in mice by activating BDNF as well as by inhibiting the expression of its transcriptional repressors (HDAC2, mSin3A, and MeCP2) and revising abnormal synaptic transmission.	sulforaphane	36-39	methyl CpG binding protein 2	Mus musculus	209-214
33429019-7	2021	However, as shown in RAW264.7 cells, the tested compounds activated Nrf2-dependent gene expression in the opposite order: sulforaphane > nitro-oleic acid >= 4-hydroxy-2-nonenal.	sulforaphane	122-134	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
33592002-0	2021	The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines.	sulforaphane	29-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
33669381-0	2021	Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression.	sulforaphane	0-12	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	78-86
33669381-5	2021	Sulforaphane regulated the expression of all of five examined lncRNAs, but basal expression, biological function and inhibition of H19 were of highest significance.	sulforaphane	0-12	H19 imprinted maternally expressed transcript	Homo sapiens	131-134
33669381-7	2021	We identified 103 common sulforaphane- and H19-related target genes and focused to the virus-induced tumor promoter APOBEC3G.	sulforaphane	25-37	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	116-124
33669381-8	2021	APOBEC3G siRNA mimicked the previously observed H19 and sulforaphane effects.	sulforaphane	56-68	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	0-8
33669381-9	2021	In vivo, sulforaphane- or H19 or APOBEC3G siRNAs led to significantly smaller tumor xenografts with reduced expression of Ki67, APOBEC3G and phospho-Smad2.	sulforaphane	9-21	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	128-136
33669381-9	2021	In vivo, sulforaphane- or H19 or APOBEC3G siRNAs led to significantly smaller tumor xenografts with reduced expression of Ki67, APOBEC3G and phospho-Smad2.	sulforaphane	9-21	SMAD family member 2	Homo sapiens	149-154
33669381-10	2021	Together, we identified APOBEC3G as H19 target, and both are inhibited by sulforaphane in prevention of PDAC progression.	sulforaphane	74-86	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	24-32
33669381-10	2021	Together, we identified APOBEC3G as H19 target, and both are inhibited by sulforaphane in prevention of PDAC progression.	sulforaphane	74-86	H19 imprinted maternally expressed transcript	Homo sapiens	36-39
33592002-4	2021	We investigated the anti-arthritic mechanisms of sulforaphane, an activator of Nrf2, in terms of its effect on B cells.	sulforaphane	49-61	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
33592002-9	2021	The joints from sulforaphane-treated CIA mice showed decreased expression of interleukin (IL)-6, IL-17, tumor necrosis factor (TNF)-alpha, receptor activator of NF-kappaB ligand, and tartrate-resistant acid phosphatase.	sulforaphane	16-28	interleukin 6	Mus musculus	77-95
33592002-9	2021	The joints from sulforaphane-treated CIA mice showed decreased expression of interleukin (IL)-6, IL-17, tumor necrosis factor (TNF)-alpha, receptor activator of NF-kappaB ligand, and tartrate-resistant acid phosphatase.	sulforaphane	16-28	interleukin 17A	Mus musculus	97-102
33592002-10	2021	Sulforaphane-treated mice showed lower circulating levels of type-II-collagen-specific IgG, IgG1, and IgG2a.	sulforaphane	0-12	immunoglobulin heavy variable V1-9	Mus musculus	102-107
33592002-12	2021	Finally, sulforaphane significantly inhibited the production of IL-6, TNF-alpha, and IL-17 by human peripheral blood mononuclear cells stimulated with an anti-CD3 monoclonal antibody in a dose-dependent manner.	sulforaphane	9-21	interleukin 6	Homo sapiens	64-68
33592002-12	2021	Finally, sulforaphane significantly inhibited the production of IL-6, TNF-alpha, and IL-17 by human peripheral blood mononuclear cells stimulated with an anti-CD3 monoclonal antibody in a dose-dependent manner.	sulforaphane	9-21	tumor necrosis factor	Homo sapiens	70-79
33592002-12	2021	Finally, sulforaphane significantly inhibited the production of IL-6, TNF-alpha, and IL-17 by human peripheral blood mononuclear cells stimulated with an anti-CD3 monoclonal antibody in a dose-dependent manner.	sulforaphane	9-21	interleukin 17A	Homo sapiens	85-90
33634123-5	2021	SFN treatment diminished the ethanol-induced upregulation of DNMT3a and dramatically reduced the activity of DNMTs in ethanol-exposed hNCCs.	sulforaphane	0-3	DNA methyltransferase 3 alpha	Homo sapiens	61-67
33563837-7	2021	Treatment with sulforaphane, an activator of Nrf2, increased resistance to MAC with increased lung expression of Nramp1 and HO-1 in wild-type mice.	sulforaphane	15-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
33634123-6	2021	We also found that ethanol exposure induced hypermethylation at the promoter regions of two inhibitor of apoptosis proteins (IAP), NAIP and XIAP, in hNCCs, which were prevented by co-treatment with SFN.	sulforaphane	198-201	NLR family apoptosis inhibitory protein	Homo sapiens	131-135
33563837-7	2021	Treatment with sulforaphane, an activator of Nrf2, increased resistance to MAC with increased lung expression of Nramp1 and HO-1 in wild-type mice.	sulforaphane	15-27	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	113-119
33563837-7	2021	Treatment with sulforaphane, an activator of Nrf2, increased resistance to MAC with increased lung expression of Nramp1 and HO-1 in wild-type mice.	sulforaphane	15-27	heme oxygenase 1	Mus musculus	124-128
33634123-6	2021	We also found that ethanol exposure induced hypermethylation at the promoter regions of two inhibitor of apoptosis proteins (IAP), NAIP and XIAP, in hNCCs, which were prevented by co-treatment with SFN.	sulforaphane	198-201	X-linked inhibitor of apoptosis	Homo sapiens	140-144
33634123-7	2021	SFN treatment also significantly diminished ethanol-induced downregulation of NAIP and XIAP in hNCCs.	sulforaphane	0-3	NLR family apoptosis inhibitory protein	Homo sapiens	78-82
33634123-7	2021	SFN treatment also significantly diminished ethanol-induced downregulation of NAIP and XIAP in hNCCs.	sulforaphane	0-3	X-linked inhibitor of apoptosis	Homo sapiens	87-91
33634123-8	2021	The knockdown of DNMT3a significantly enhanced the effects of SFN on preventing the ethanol-induced repression of NAIP and XIAP and apoptosis in hNCCs.	sulforaphane	62-65	DNA methyltransferase 3 alpha	Homo sapiens	17-23
33634123-8	2021	The knockdown of DNMT3a significantly enhanced the effects of SFN on preventing the ethanol-induced repression of NAIP and XIAP and apoptosis in hNCCs.	sulforaphane	62-65	NLR family apoptosis inhibitory protein	Homo sapiens	114-118
33634123-8	2021	The knockdown of DNMT3a significantly enhanced the effects of SFN on preventing the ethanol-induced repression of NAIP and XIAP and apoptosis in hNCCs.	sulforaphane	62-65	X-linked inhibitor of apoptosis	Homo sapiens	123-127
33477669-5	2021	We will then focus on the promising therapeutic potential of sulforaphane, an isothiocyanate derived from cruciferous vegetables that has garnered significant attention over the past decade for its potent Nrf2-activating effect, and implications for precision medicine.	sulforaphane	61-73	NFE2 like bZIP transcription factor 2	Homo sapiens	205-209
33510228-0	2021	Sulforaphane induces S-phase arrest and apoptosis via p53-dependent manner in gastric cancer cells.	sulforaphane	0-12	tumor protein p53	Homo sapiens	54-57
33510228-7	2021	These results suggested that SFN-induced S phase cell cycle arrest and apoptosis through p53-dependent manner in GC cells, which suggested that SFN has a potential therapeutic application in the treatment and prevention of GC.	sulforaphane	29-32	tumor protein p53	Homo sapiens	89-92
33471780-0	2021	Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling.	sulforaphane	0-12	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	62-68
33471780-0	2021	Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling.	sulforaphane	0-12	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	69-74
33471780-5	2021	Mechanistically, sulforaphane inhibited DAF-2-mediated insulin/insulin-like growth factor signaling and its downstream targets AGE-1, AKT-1/AKT-2.	sulforaphane	17-29	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	40-45
33471780-5	2021	Mechanistically, sulforaphane inhibited DAF-2-mediated insulin/insulin-like growth factor signaling and its downstream targets AGE-1, AKT-1/AKT-2.	sulforaphane	17-29	Phosphatidylinositol 3-kinase age-1	Caenorhabditis elegans	127-132
33471780-5	2021	Mechanistically, sulforaphane inhibited DAF-2-mediated insulin/insulin-like growth factor signaling and its downstream targets AGE-1, AKT-1/AKT-2.	sulforaphane	17-29	Serine/threonine-protein kinase akt-1	Caenorhabditis elegans	134-139
33471780-5	2021	Mechanistically, sulforaphane inhibited DAF-2-mediated insulin/insulin-like growth factor signaling and its downstream targets AGE-1, AKT-1/AKT-2.	sulforaphane	17-29	Serine/threonine-protein kinase akt-2	Caenorhabditis elegans	140-145
33094879-6	2021	Conversely, SFN administration decreased the expression of the epigenesis-related genes (HDAC1 and DNMT1) and inflammation-related genes (TNFa, NFkB and Cox2).	sulforaphane	12-15	histone deacetylase 1	Mus musculus	89-94
33094879-6	2021	Conversely, SFN administration decreased the expression of the epigenesis-related genes (HDAC1 and DNMT1) and inflammation-related genes (TNFa, NFkB and Cox2).	sulforaphane	12-15	DNA methyltransferase (cytosine-5) 1	Mus musculus	99-104
33094879-6	2021	Conversely, SFN administration decreased the expression of the epigenesis-related genes (HDAC1 and DNMT1) and inflammation-related genes (TNFa, NFkB and Cox2).	sulforaphane	12-15	tumor necrosis factor	Mus musculus	138-142
33094879-6	2021	Conversely, SFN administration decreased the expression of the epigenesis-related genes (HDAC1 and DNMT1) and inflammation-related genes (TNFa, NFkB and Cox2).	sulforaphane	12-15	cytochrome c oxidase II, mitochondrial	Mus musculus	153-157
33064289-0	2021	R-sulforaphane modulates the expression profile of AhR, ERalpha, Nrf2, NQO1, and GSTP in human breast cell lines.	sulforaphane	0-14	aryl hydrocarbon receptor	Homo sapiens	51-54
33064289-0	2021	R-sulforaphane modulates the expression profile of AhR, ERalpha, Nrf2, NQO1, and GSTP in human breast cell lines.	sulforaphane	0-14	estrogen receptor 1	Homo sapiens	56-63
33064289-0	2021	R-sulforaphane modulates the expression profile of AhR, ERalpha, Nrf2, NQO1, and GSTP in human breast cell lines.	sulforaphane	0-14	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
33064289-0	2021	R-sulforaphane modulates the expression profile of AhR, ERalpha, Nrf2, NQO1, and GSTP in human breast cell lines.	sulforaphane	0-14	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-75
33064289-0	2021	R-sulforaphane modulates the expression profile of AhR, ERalpha, Nrf2, NQO1, and GSTP in human breast cell lines.	sulforaphane	0-14	glutathione S-transferase pi 1	Homo sapiens	81-85
33064289-2	2021	This study aimed to evaluate the effect of R-SFN on phase II enzymes induction and expression of AhR, Nrf2, and ERalpha in the same breast cell lines.	sulforaphane	43-48	aryl hydrocarbon receptor	Homo sapiens	97-100
33064289-2	2021	This study aimed to evaluate the effect of R-SFN on phase II enzymes induction and expression of AhR, Nrf2, and ERalpha in the same breast cell lines.	sulforaphane	43-48	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
33064289-2	2021	This study aimed to evaluate the effect of R-SFN on phase II enzymes induction and expression of AhR, Nrf2, and ERalpha in the same breast cell lines.	sulforaphane	43-48	estrogen receptor 1	Homo sapiens	112-119
33498683-3	2021	Here, we exposed HepG2 hepatoma cells cultured under Se-deficient, Se-adequate, or Se-supranutritional conditions to the Nrf2 activators sulforaphane, cardamonin, or diethyl maleate.	sulforaphane	137-149	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
32281399-7	2021	Common nutritional Nrf2 activators include sulforaphane, curcumin, DATS, quercetin, resveratrol, and EGCG.	sulforaphane	43-55	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	30-42	NAD(P)H quinone dehydrogenase 1	Homo sapiens	109-141
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	30-42	NAD(P)H quinone dehydrogenase 1	Homo sapiens	143-147
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	30-42	kelch like ECH associated protein 1	Homo sapiens	248-253
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	30-42	NFE2 like bZIP transcription factor 2	Homo sapiens	281-285
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	44-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	109-141
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	44-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	143-147
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	44-47	kelch like ECH associated protein 1	Homo sapiens	248-253
31721705-2	2021	BACKGROUND: The phytochemical sulforaphane (SFN) is a potent inducer of carcinogen detoxication enzymes like NAD(P)H:quinone oxidoreductase 1 (NQO1) through the Kelch-like erythroid cell-derived protein with CNC homology[ECH]-associated protein 1 (Keap1)-[NF-E2]-related factor 2 (Nrf2) signaling pathway.	sulforaphane	44-47	NFE2 like bZIP transcription factor 2	Homo sapiens	281-285
31721705-3	2021	OBJECTIVE: In this paper, we report the first QSAR and pharmacophore modeling study of sulforaphane analogues as NQO1 inducers.	sulforaphane	87-99	NAD(P)H quinone dehydrogenase 1	Homo sapiens	113-117
31721705-4	2021	The pharmacophore model and understanding the relationships between the structures and activities of the known inducers will give useful information on the structural basis for NQO1 enzymatic activity and lead optimization for future rational design of new sulforaphane analogues as potent NQO1 inducers.	sulforaphane	257-269	NAD(P)H quinone dehydrogenase 1	Homo sapiens	177-181
31721705-4	2021	The pharmacophore model and understanding the relationships between the structures and activities of the known inducers will give useful information on the structural basis for NQO1 enzymatic activity and lead optimization for future rational design of new sulforaphane analogues as potent NQO1 inducers.	sulforaphane	257-269	NAD(P)H quinone dehydrogenase 1	Homo sapiens	290-294
31721705-5	2021	METHOD: In this study, a combination of QSAR modeling, pharmacophore generation, virtual screening and molecular docking was performed on a series of sulforaphane analogues as NQO1 inducers.	sulforaphane	150-162	NAD(P)H quinone dehydrogenase 1	Homo sapiens	176-180
33467537-10	2021	The efficacy was more significant when the concentration of SFN was 60 mg mL-1.	sulforaphane	60-63	2'-5' oligoadenylate synthetase 1B	Mus musculus	74-78
33436962-0	2021	Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-gamma-mediated inflammation in doxorubicin-treated macrophages.	sulforaphane	62-74	interferon gamma	Mus musculus	87-96
33096251-7	2021	When tested head to head with sulforaphane, a covalent KEAP1 binder, Compound 2 had a similar ability to induce the expression of genes known to be modulated by NRF2 in neurons and astrocytes isolated from wild-type rat, wild type mouse and zQ175 (an HD mouse model) embryos.	sulforaphane	30-42	Kelch-like ECH-associated protein 1	Rattus norvegicus	55-60
33160067-0	2021	THE PHYTOPROTECTIVE AGENT SULFORAPHANE PREVENTS INFLAMMATORY DEGENERATIVE DISEASES AND AGE-RELATED PATHOLOGIES VIA NRF2-MEDIATED HORMESIS.	sulforaphane	26-38	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
33365082-0	2021	Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane.	sulforaphane	83-95	solute carrier family 7 member 11	Homo sapiens	61-68
33365082-10	2021	These results indicated that the anticancer effects of SFN may be caused by ferroptosis in the SCLC cells, which was hypothesized to be triggered from the inhibition of mRNA and protein expression levels of SLC7A11.	sulforaphane	55-58	solute carrier family 7 member 11	Homo sapiens	207-214
33365082-11	2021	In conclusion, the present study demonstrated that SFN-induced cell death was mediated via ferroptosis and inhibition of the mRNA and protein expression levels of SLC7A11 in SCLC cells.	sulforaphane	51-54	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	163-170
33292691-3	2020	There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm.	sulforaphane	125-137	NFE2 like bZIP transcription factor 2	Homo sapiens	15-19
33126057-3	2021	In this study, we found that the antifibrotic function of sulforaphane (SFN), an NRF2 activator, was largely dependent on LOC344887, a long noncoding RNA.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
33126057-3	2021	In this study, we found that the antifibrotic function of sulforaphane (SFN), an NRF2 activator, was largely dependent on LOC344887, a long noncoding RNA.	sulforaphane	72-75	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
33321464-6	2021	Conversely, exposures to antioxidant N-acetylcysteine (bolsters GSH pools; 100 muM; 48-72 hpf) or sulforaphane (activates Nrf2a; 20 muM; 48-72 hpf) significantly increased islet areas.	sulforaphane	98-110	nfe2 like bZIP transcription factor 2a	Danio rerio	122-127
33338213-1	2021	Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	134-177
33338213-1	2021	Sulforaphane (SFN) is a sulfur-containing isothiocyanate found in cruciferous vegetables (Brassicaceae) and a well-known activator of nuclear factor-erythroid 2-related factor 2 (Nrf2), considered a master regulator of cellular antioxidant responses.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	179-183
33292691-3	2020	There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm.	sulforaphane	125-137	insulin	Homo sapiens	172-179
32895018-11	2020	In synhACE2-/- mice, the central Ang II pressor response was attenuated by simultaneous intracerebroventricular infusion of the Nrf2 activator sulforaphane; blood pressure was enhanced by knockdown of Nrf2 in the rostral ventrolateral medulla in Nrf2 floxed (Nrf2f/f) mice.	sulforaphane	143-155	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	33-39
33218199-0	2020	Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7.	sulforaphane	0-12	proliferating cell nuclear antigen	Homo sapiens	98-104
33218199-0	2020	Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7.	sulforaphane	0-12	CD44 molecule (Indian blood group)	Homo sapiens	132-136
33218199-7	2020	However, alterations occurring in the Cdk-cyclin axis, modification of the p19 and p27 proteins and changes in CD44v4, v5, and v7 expression because of SFN exposure differed in the two cell lines.	sulforaphane	152-155	CD44 molecule (Indian blood group)	Homo sapiens	111-115
32938216-7	2020	Moreover, activation of the Nrf2 pathway by sulforaphane suppressed Ang II-induced VSMC phenotypic switching and proliferation, indicating that Nrf2 is a key regulator of VSMC phenotypic switching and vascular homeostasis.	sulforaphane	44-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	28-32
32938216-7	2020	Moreover, activation of the Nrf2 pathway by sulforaphane suppressed Ang II-induced VSMC phenotypic switching and proliferation, indicating that Nrf2 is a key regulator of VSMC phenotypic switching and vascular homeostasis.	sulforaphane	44-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-148
33067900-0	2020	Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
33067900-3	2020	Sulforaphane (SFN), a natural compound Nrf2-related activator of cytoprotective genes, provides protection in several disease states including CVD and is in various stages of clinical trials, from cancer prevention to reducing insulin resistance.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
33067900-3	2020	Sulforaphane (SFN), a natural compound Nrf2-related activator of cytoprotective genes, provides protection in several disease states including CVD and is in various stages of clinical trials, from cancer prevention to reducing insulin resistance.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
32895018-11	2020	In synhACE2-/- mice, the central Ang II pressor response was attenuated by simultaneous intracerebroventricular infusion of the Nrf2 activator sulforaphane; blood pressure was enhanced by knockdown of Nrf2 in the rostral ventrolateral medulla in Nrf2 floxed (Nrf2f/f) mice.	sulforaphane	143-155	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
32773768-5	2020	METHODS: CD44+/CD271+ FACS-isolated CSCs from SCC12 and SCC38 human cell lines were treated with SF alone or combined with CIS or 5-FU.	sulforaphane	97-99	CD44 molecule (Indian blood group)	Homo sapiens	9-13
33079284-4	2022	Sulforaphane prevented the LPS-induced increase in the expression and/or release of pro-inflammatory mediators, possibly due to nuclear factor kappaB and hypoxia-inducible factor-1alpha activation.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	154-185
33079284-6	2022	Additionally, sulforaphane increased the mRNA levels of nuclear factor erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO1), both of which mediate several cytoprotective responses.	sulforaphane	14-26	NFE2 like bZIP transcription factor 2	Homo sapiens	56-97
33079284-6	2022	Additionally, sulforaphane increased the mRNA levels of nuclear factor erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO1), both of which mediate several cytoprotective responses.	sulforaphane	14-26	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
33079284-6	2022	Additionally, sulforaphane increased the mRNA levels of nuclear factor erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO1), both of which mediate several cytoprotective responses.	sulforaphane	14-26	heme oxygenase 1	Homo sapiens	109-125
33079284-6	2022	Additionally, sulforaphane increased the mRNA levels of nuclear factor erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO1), both of which mediate several cytoprotective responses.	sulforaphane	14-26	heme oxygenase 1	Homo sapiens	127-130
33079284-9	2022	Interestingly, the anti-inflammatory and antioxidant effects of sulforaphane were blocked by HO1 pharmacological inhibition, suggesting its dependence on HO1 activity.	sulforaphane	64-76	heme oxygenase 1	Homo sapiens	93-96
33079284-9	2022	Interestingly, the anti-inflammatory and antioxidant effects of sulforaphane were blocked by HO1 pharmacological inhibition, suggesting its dependence on HO1 activity.	sulforaphane	64-76	heme oxygenase 1	Homo sapiens	154-157
33079284-10	2022	Finally, in support of a glioprotective role, sulforaphane prevented the LPS-induced decrease in glutamate uptake, glutamine synthetase activity, and glial-derived neurotrophic factor (GDNF) levels, as well as the augmentations in S100B release and Na+, K+ ATPase activity.	sulforaphane	46-58	glutamate-ammonia ligase	Homo sapiens	115-135
33079284-10	2022	Finally, in support of a glioprotective role, sulforaphane prevented the LPS-induced decrease in glutamate uptake, glutamine synthetase activity, and glial-derived neurotrophic factor (GDNF) levels, as well as the augmentations in S100B release and Na+, K+ ATPase activity.	sulforaphane	46-58	glial cell derived neurotrophic factor	Homo sapiens	150-183
33079284-10	2022	Finally, in support of a glioprotective role, sulforaphane prevented the LPS-induced decrease in glutamate uptake, glutamine synthetase activity, and glial-derived neurotrophic factor (GDNF) levels, as well as the augmentations in S100B release and Na+, K+ ATPase activity.	sulforaphane	46-58	glial cell derived neurotrophic factor	Homo sapiens	185-189
33079284-10	2022	Finally, in support of a glioprotective role, sulforaphane prevented the LPS-induced decrease in glutamate uptake, glutamine synthetase activity, and glial-derived neurotrophic factor (GDNF) levels, as well as the augmentations in S100B release and Na+, K+ ATPase activity.	sulforaphane	46-58	S100 calcium binding protein B	Homo sapiens	231-236
33078098-0	2020	Sulforaphane modulates TGFbeta2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling.	sulforaphane	0-12	transforming growth factor beta 2	Homo sapiens	23-31
33078098-0	2020	Sulforaphane modulates TGFbeta2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	108-111
33078098-1	2020	AIM: To examine the effects of sulforaphane on fibrotic changes of transforming growth factor (TGFbeta2) induced human conjunctival fibroblast (HConFs).	sulforaphane	31-43	transforming growth factor beta 2	Homo sapiens	95-103
33078098-10	2020	TGFbeta2-induced the increasing expression of fibronectin, type I collagen and alpha-SMA, and the phosphorylation of PI3K and Akt were all significantly suppressed by sulforaphane pretreatment.	sulforaphane	167-179	transforming growth factor beta 2	Homo sapiens	0-8
33078098-10	2020	TGFbeta2-induced the increasing expression of fibronectin, type I collagen and alpha-SMA, and the phosphorylation of PI3K and Akt were all significantly suppressed by sulforaphane pretreatment.	sulforaphane	167-179	fibronectin 1	Homo sapiens	46-57
33078098-10	2020	TGFbeta2-induced the increasing expression of fibronectin, type I collagen and alpha-SMA, and the phosphorylation of PI3K and Akt were all significantly suppressed by sulforaphane pretreatment.	sulforaphane	167-179	actin alpha 1, skeletal muscle	Homo sapiens	79-88
33078098-10	2020	TGFbeta2-induced the increasing expression of fibronectin, type I collagen and alpha-SMA, and the phosphorylation of PI3K and Akt were all significantly suppressed by sulforaphane pretreatment.	sulforaphane	167-179	AKT serine/threonine kinase 1	Homo sapiens	126-129
33078098-11	2020	CONCLUSION: Sulforaphane inhibits proliferation, migration, and synthesis of the extracellular matrix in HConFs, and inhibiting the PI3K/Akt signaling pathway.	sulforaphane	12-24	AKT serine/threonine kinase 1	Homo sapiens	137-140
33001866-4	2020	Moreover, mottled skin pigmentation in humans could be treated with topical application of the NRF2 inducer sulforaphane (SF).	sulforaphane	108-120	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
33001866-4	2020	Moreover, mottled skin pigmentation in humans could be treated with topical application of the NRF2 inducer sulforaphane (SF).	sulforaphane	122-124	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
33040081-0	2020	TAp63alpha targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition.	sulforaphane	81-93	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	24-28
33193420-0	2020	Sulforaphane Promotes Dendritic Cell Stimulatory Capacity Through Modulation of Regulatory Molecules, JAK/STAT3- and MicroRNA-Signaling.	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	106-111
33193420-7	2020	Results: Sulforaphane modulated the expression of the costimulatory CD80, CD83 and the suppressive B7-H1 molecules on dendritic cells and thereby promoted activation of T cells.	sulforaphane	9-21	CD80 antigen	Mus musculus	68-72
33193420-7	2020	Results: Sulforaphane modulated the expression of the costimulatory CD80, CD83 and the suppressive B7-H1 molecules on dendritic cells and thereby promoted activation of T cells.	sulforaphane	9-21	CD83 antigen	Mus musculus	74-78
33193420-7	2020	Results: Sulforaphane modulated the expression of the costimulatory CD80, CD83 and the suppressive B7-H1 molecules on dendritic cells and thereby promoted activation of T cells.	sulforaphane	9-21	CD274 antigen	Mus musculus	99-104
33193420-9	2020	Phosphorylation of STAT3 in dendritic cells was diminished by sulforaphane, and the inhibition of JAK/STAT3 led to downregulation of B7-H1 expression.	sulforaphane	62-74	signal transducer and activator of transcription 3	Homo sapiens	19-24
33193420-10	2020	Among the identified top 100 significant microRNA candidates, the inhibition of miR-155-5p, important for the expression of costimulatory molecules, and the induction of miR-194-5p, targeting the B7-H1 gene, were induced by sulforaphane.	sulforaphane	224-236	microRNA 155	Homo sapiens	80-87
33193420-10	2020	Among the identified top 100 significant microRNA candidates, the inhibition of miR-155-5p, important for the expression of costimulatory molecules, and the induction of miR-194-5p, targeting the B7-H1 gene, were induced by sulforaphane.	sulforaphane	224-236	CD274 antigen	Mus musculus	196-201
33193420-11	2020	Conclusion: Our findings demonstrate that sulforaphane promotes T-cell activation by dendritic cells through the modulation of regulatory molecules, JAK/STAT3- and microRNA-signaling in healthy conditions and in context of pancreatic cancer-derived antigens.	sulforaphane	42-54	signal transducer and activator of transcription 3	Homo sapiens	153-158
33023225-0	2020	Discovery of Sulforaphane as a Potent BACE1 Inhibitor Based on Kinetics and Computational Studies.	sulforaphane	13-25	beta-secretase 1	Homo sapiens	38-43
33023225-3	2020	In the present study, the potential of sulforaphane, an isothiocyanate found in cruciferous vegetables, as a BACE1 inhibitor has been investigated.	sulforaphane	39-51	beta-secretase 1	Homo sapiens	109-114
33023225-4	2020	Sulforaphane exhibited six times more potent activity against BACE1 compared to well-known positive controls including resveratrol and quercetin.	sulforaphane	0-12	beta-secretase 1	Homo sapiens	62-67
33023225-5	2020	Sulforaphane presented selective and non-competitive BACE1 inhibitory activity with low off-target inhibition of BACE2 and other aspartic and serine proteases.	sulforaphane	0-12	beta-secretase 1	Homo sapiens	53-58
33023225-5	2020	Sulforaphane presented selective and non-competitive BACE1 inhibitory activity with low off-target inhibition of BACE2 and other aspartic and serine proteases.	sulforaphane	0-12	beta-secretase 2	Homo sapiens	113-118
33023225-6	2020	In addition, sulforaphane presented negative binding energy, suggesting that the compound had a high affinity for BACE1.	sulforaphane	13-25	beta-secretase 1	Homo sapiens	114-119
33023225-8	2020	Overall, sulforaphane appeared to be a promising candidate with potent and selective BACE1 inhibitory properties that play an important role in AD prevention.	sulforaphane	9-21	beta-secretase 1	Homo sapiens	85-90
32738361-0	2020	Sulforaphane suppresses obesity-related glomerulopathy-induced damage by enhancing autophagy via Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
31594422-4	2020	SFN is not a H2S donor but it acts via stimulating H2S generation in the brain catalyzed by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	sulforaphane	0-3	cystathionine gamma-lyase	Homo sapiens	92-117
31594422-4	2020	SFN is not a H2S donor but it acts via stimulating H2S generation in the brain catalyzed by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	sulforaphane	0-3	cystathionine gamma-lyase	Homo sapiens	119-122
31594422-4	2020	SFN is not a H2S donor but it acts via stimulating H2S generation in the brain catalyzed by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	sulforaphane	0-3	cystathionine beta-synthase	Homo sapiens	128-155
31594422-5	2020	CSE/CBS inhibitors propargylglycine, beta-cyano-L-alanine, and aminooxyacetic acid blocked brain H2S generation and cerebral vasodilation caused by SFN.	sulforaphane	148-151	cystathionine gamma-lyase	Homo sapiens	0-3
31594422-8	2020	Overall, we provide first evidence that SFN is a brain permeable compound that increases cerebral blood flow via a non-genomic mechanism that is mediated via activation of CSE/CBS-catalyzed H2S formation in neurovascular cells followed by H2S-induced activation of KATP and BK channels in arteriolar smooth muscle.	sulforaphane	40-43	cystathionine gamma-lyase	Homo sapiens	172-175
32738361-14	2020	SIGNIFICANCE: Treatment with SFN limited ORG-induced damage by enhancing podocyte autophagy via Nrf2.	sulforaphane	29-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
32710977-0	2020	Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic stress-induced aggravation of acute alcoholism via targeting Nrf2-regulated catalase expression.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
32710977-0	2020	Sulforaphane alleviates ethanol-mediated central inhibition and reverses chronic stress-induced aggravation of acute alcoholism via targeting Nrf2-regulated catalase expression.	sulforaphane	0-12	catalase	Homo sapiens	157-165
32710977-7	2020	Sulforaphane, a cruciferous vegetable-derived activator of Nrf2, significantly attenuated acute ethanol intoxication.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
32940670-0	2020	Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 anti-oxidative function.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
32659677-2	2020	Sulforaphane (4-methylsulfinylbutyl isothiocyanate, SFN), commonly found in cruciferous vegetables, has diverse biological effects on skin tissue.	sulforaphane	0-12	RNA exonuclease 2	Homo sapiens	52-55
32949969-0	2020	Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation.	sulforaphane	115-127	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
32949969-4	2020	Our previous studies in a rodent model of ischemic stroke established that activation of Nrf2 defense enzymes by pretreatment with sulforaphane (SFN) affords protection against neurovascular and neurological deficits.	sulforaphane	131-143	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
32949969-4	2020	Our previous studies in a rodent model of ischemic stroke established that activation of Nrf2 defense enzymes by pretreatment with sulforaphane (SFN) affords protection against neurovascular and neurological deficits.	sulforaphane	145-148	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
32949969-7	2020	Induction of HO-1 and GCLM by SFN (2.5 muM) was significantly attenuated in cells adapted to 5 kPa O2, despite nuclear accumulation of Nrf2.	sulforaphane	30-33	heme oxygenase 1	Mus musculus	13-17
32949969-7	2020	Induction of HO-1 and GCLM by SFN (2.5 muM) was significantly attenuated in cells adapted to 5 kPa O2, despite nuclear accumulation of Nrf2.	sulforaphane	30-33	glutamate-cysteine ligase, modifier subunit	Mus musculus	22-26
33242767-4	2020	In proliferating and differentiating neuroblastoma (Neuro 2a/N2a) cells, sulforaphane-mediated Nrf2 activation resulted in increased transcription/translation of antioxidants and glutathione (GSH) production along with significantly declined ROS in a dose-dependent manner leading to a reductive-redox state (i.e. RS).	sulforaphane	73-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
32940670-1	2020	Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-139
32940670-1	2020	Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
32940670-1	2020	Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-139
32940670-1	2020	Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 2 diabetes (T2D) by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
32371093-10	2020	In contrast, Nrf2 induction by sulforaphane was protective.	sulforaphane	31-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	13-17
32401383-10	2020	Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation.	sulforaphane	17-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
32856616-5	2020	The synergistic effect of sulforaphane and auranofin on apoptosis was evidenced by an increased annexin-V-positive cells and Sub-G1 cells.	sulforaphane	26-38	annexin A5	Homo sapiens	96-105
32856616-11	2020	Furthermore, apoptosis induced by auranofin and sulforaphane was significantly increased through inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway.	sulforaphane	48-60	AKT serine/threonine kinase 1	Homo sapiens	148-151
32856616-12	2020	Taken together, the present study demonstrated that down-regulation of TrxR activity contributed to the synergistic effect of auranofin and sulforaphane on apoptosis through ROS production and inhibition of PI3K/Akt signaling pathway.	sulforaphane	140-152	AKT serine/threonine kinase 1	Homo sapiens	212-215
32401383-0	2020	Sulforaphane ameliorates serum starvation-induced muscle atrophy via activation of the Nrf2 pathway in cultured C2C12 cells.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
32401383-10	2020	Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation.	sulforaphane	17-29	heme oxygenase 1	Mus musculus	119-123
32401383-10	2020	Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation.	sulforaphane	17-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
32401383-10	2020	Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation.	sulforaphane	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
32401383-10	2020	Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation.	sulforaphane	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
32401383-10	2020	Pre-treatment of sulforaphane (SFN), a known Nrf2 inducer, before serum starvation showed a protective effect via Nrf2/HO-1 upregulation.	sulforaphane	31-34	heme oxygenase 1	Mus musculus	119-123
32401383-12	2020	Consequently, the expression of HO-1 increased and intracellular ROS was significantly reduced by SFN pre-treatment.	sulforaphane	98-101	heme oxygenase 1	Mus musculus	32-36
32828016-10	2020	We also analyzed the effects of the Nrf2 activator sulforaphane in these mutants and found that keap1a-, but not keap1b-, knockout larvae responded to sulforaphane, suggesting that the stress/chemical-sensing abilities of the two Keap1s are different.	sulforaphane	151-163	kelch-like ECH-associated protein 1a	Danio rerio	96-102
31837923-2	2020	We explored whether antioxidant sulforaphane,a NF-E2-related nuclear factor erythroid-2 (Nrf-2) activator, may ameliorate DM-induced bladder dysfunction.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	47-87
32705150-0	2020	Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT-1.	sulforaphane	0-12	FAT atypical cadherin 1	Homo sapiens	137-142
32705150-6	2020	The viability of and FAT1 expression in T24 and SW780 cells exposed to various concentrations of SFN were detected by MTT assay, and western blot analysis and RT-qPCR, respectively.	sulforaphane	97-100	FAT atypical cadherin 1	Homo sapiens	21-25
31837923-2	2020	We explored whether antioxidant sulforaphane,a NF-E2-related nuclear factor erythroid-2 (Nrf-2) activator, may ameliorate DM-induced bladder dysfunction.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-94
32387680-8	2020	SFN and SFNAC attenuated CSE/PM-induced epithelial toxicity through the ERK/JNK signaling pathway-dependent inhibition of inflammation.	sulforaphane	0-3	mitogen-activated protein kinase 1	Homo sapiens	72-75
32387680-9	2020	Moreover, SFN and SFNAC suppressed ROS generation by activating antioxidant enzymes and Nrf2 signaling.	sulforaphane	10-13	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
32387680-8	2020	SFN and SFNAC attenuated CSE/PM-induced epithelial toxicity through the ERK/JNK signaling pathway-dependent inhibition of inflammation.	sulforaphane	0-3	mitogen-activated protein kinase 8	Homo sapiens	76-79
32711925-5	2020	NRF2 activators such as sulforaphane and bardoxolone methyl are already in clinical trials.	sulforaphane	24-36	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32860670-0	2020	Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.	sulforaphane	0-12	cyclin dependent kinase 4	Homo sapiens	36-40
32860670-0	2020	Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells.	sulforaphane	0-12	cyclin dependent kinase 6	Homo sapiens	42-46
32854194-10	2020	Importantly, sulforaphane (NRF2 activator) reversed HA-promoted renal fibrosis.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
32858866-11	2020	Sulforaphane may enhance innate antioxidant and anti-inflammatory capacity by increasing NRF-2 expression.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	89-94
32079911-7	2020	Moreover, the expression of LDH-B and LDH activity of converting lactate into pyruvate, as well as citrate synthase activity were significantly higher; while the LDH activity of converting pyruvate into lactate and blood lactate level were remarkably lower in the SFN-exercise mice than those of the PBS-exercise group.	sulforaphane	264-267	lactate dehydrogenase B	Mus musculus	28-33
32507349-6	2020	METHOD: Three phytochemicals; Sulforaphane, Curcumin, and Resveratrol were selected, and studies were reviewed to clarify their intracellular signaling mechanism in NLRP3 inflammasome activity.	sulforaphane	30-42	NLR family pyrin domain containing 3	Homo sapiens	165-170
32759798-8	2020	CD44v4 and v7 increased on RT112 cells following exposure to SFN or SFN-everolimus.	sulforaphane	61-64	CD44 molecule (Indian blood group)	Homo sapiens	0-4
32243901-5	2020	The antioxidant sulforaphane (SFN) inhibits the proliferation of BC cells and causes a redistribution of the subcellular localization of PML, a disruption of disulfide-bond linkages in nuclear PML-containing complexes, and a reduction in the number and size of PML NBs.	sulforaphane	16-28	PML nuclear body scaffold	Homo sapiens	193-196
32243901-5	2020	The antioxidant sulforaphane (SFN) inhibits the proliferation of BC cells and causes a redistribution of the subcellular localization of PML, a disruption of disulfide-bond linkages in nuclear PML-containing complexes, and a reduction in the number and size of PML NBs.	sulforaphane	16-28	PML nuclear body scaffold	Homo sapiens	193-196
32243901-5	2020	The antioxidant sulforaphane (SFN) inhibits the proliferation of BC cells and causes a redistribution of the subcellular localization of PML, a disruption of disulfide-bond linkages in nuclear PML-containing complexes, and a reduction in the number and size of PML NBs.	sulforaphane	30-33	PML nuclear body scaffold	Homo sapiens	137-140
32243901-5	2020	The antioxidant sulforaphane (SFN) inhibits the proliferation of BC cells and causes a redistribution of the subcellular localization of PML, a disruption of disulfide-bond linkages in nuclear PML-containing complexes, and a reduction in the number and size of PML NBs.	sulforaphane	30-33	PML nuclear body scaffold	Homo sapiens	193-196
32243901-5	2020	The antioxidant sulforaphane (SFN) inhibits the proliferation of BC cells and causes a redistribution of the subcellular localization of PML, a disruption of disulfide-bond linkages in nuclear PML-containing complexes, and a reduction in the number and size of PML NBs.	sulforaphane	30-33	PML nuclear body scaffold	Homo sapiens	193-196
32434809-0	2020	The Role of Lysosome-Associated Membrane Protein 2 in Prostate Cancer Chemopreventive Mechanisms of Sulforaphane.	sulforaphane	100-112	lysosomal associated membrane protein 2	Homo sapiens	12-50
32434809-4	2020	Western blotting revealed dose-dependent induction of LAMP2 protein after treatment with SFN as well as its naturally-occurring analogs in PC-3 and 22Rv1 human prostate cancer cell lines that was confirmed by microscopy (SFN).	sulforaphane	89-92	lysosomal associated membrane protein 2	Homo sapiens	54-59
32434809-7	2020	Apoptosis induction by SFN treatment was also increased significantly by knockdown of the LAMP2 protein in PC-3 and 22Rv1 cells.	sulforaphane	23-26	lysosomal associated membrane protein 2	Homo sapiens	90-95
32434809-12	2020	In conclusion, the present study reveals that induction of LAMP2 by SFN inhibits its ability to induce apoptotic cell death at least in human prostate cancer cells.	sulforaphane	68-71	lysosomal associated membrane protein 2	Homo sapiens	59-64
32416457-0	2020	CT1-3, a novel magnolol-sulforaphane hybrid suppresses tumorigenesis through inducing mitochondria-mediated apoptosis and inhibiting epithelial mesenchymal transition.	sulforaphane	24-36	MAGE family member A3	Homo sapiens	0-5
32784785-5	2020	This review focuses on results from clinical trials with four agents known to target NRF2 signaling in preclinical studies (dimethyl fumarate, bardoxolone methyl, oltipraz, and sulforaphane), and evaluates the successes and limitations of biomarkers focused on expression of NRF2 target genes and others, inflammation and oxidative stress biomarkers, carcinogen metabolism and adduct biomarkers in unavoidably exposed populations, and targeted and untargeted metabolomics.	sulforaphane	177-189	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
32243901-0	2020	The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN).	sulforaphane	105-117	PML nuclear body scaffold	Homo sapiens	4-34
32243901-0	2020	The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN).	sulforaphane	119-122	PML nuclear body scaffold	Homo sapiens	4-34
32243901-5	2020	The antioxidant sulforaphane (SFN) inhibits the proliferation of BC cells and causes a redistribution of the subcellular localization of PML, a disruption of disulfide-bond linkages in nuclear PML-containing complexes, and a reduction in the number and size of PML NBs.	sulforaphane	16-28	PML nuclear body scaffold	Homo sapiens	137-140
32079911-4	2020	METHODS: In this study, C57BL/6J mice were administrated with a Nrf2 activator, sulforaphane (SFN), before taking incremental treadmill exercise to exhaustion under hypoxia; then the effects of SFN on exercise endurance and molecular/biochemical makers of skeletal muscle were evaluated.	sulforaphane	80-92	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
32079911-4	2020	METHODS: In this study, C57BL/6J mice were administrated with a Nrf2 activator, sulforaphane (SFN), before taking incremental treadmill exercise to exhaustion under hypoxia; then the effects of SFN on exercise endurance and molecular/biochemical makers of skeletal muscle were evaluated.	sulforaphane	94-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
32079911-7	2020	Moreover, the expression of LDH-B and LDH activity of converting lactate into pyruvate, as well as citrate synthase activity were significantly higher; while the LDH activity of converting pyruvate into lactate and blood lactate level were remarkably lower in the SFN-exercise mice than those of the PBS-exercise group.	sulforaphane	264-267	lactate dehydrogenase B	Mus musculus	28-31
32079911-7	2020	Moreover, the expression of LDH-B and LDH activity of converting lactate into pyruvate, as well as citrate synthase activity were significantly higher; while the LDH activity of converting pyruvate into lactate and blood lactate level were remarkably lower in the SFN-exercise mice than those of the PBS-exercise group.	sulforaphane	264-267	lactate dehydrogenase B	Mus musculus	38-41
32760724-4	2020	Using gene expression analyses in wt and AMPKalpha1 -/- or Nrf2 -/- mouse embryonal fibroblasts, we could show that AMPK only affected a portion of the entire of Nrf2-dependent transcriptome upon exposure to the Nrf2 activator sulforaphane (Sfn).	sulforaphane	227-239	nuclear factor, erythroid derived 2, like 2	Mus musculus	162-166
32760724-4	2020	Using gene expression analyses in wt and AMPKalpha1 -/- or Nrf2 -/- mouse embryonal fibroblasts, we could show that AMPK only affected a portion of the entire of Nrf2-dependent transcriptome upon exposure to the Nrf2 activator sulforaphane (Sfn).	sulforaphane	227-239	nuclear factor, erythroid derived 2, like 2	Mus musculus	162-166
32621086-10	2020	Meanwhile, treatment with sulforaphane effectively reducted the damage scores and MPO activity.	sulforaphane	26-38	myeloperoxidase	Mus musculus	82-85
32476238-0	2020	Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.	sulforaphane	0-12	mechanistic target of rapamycin kinase	Homo sapiens	97-101
32476238-0	2020	Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3.	sulforaphane	0-12	transcription factor binding to IGHM enhancer 3	Homo sapiens	102-106
32361680-5	2020	Satellite cell-like C2C12 myoblasts were treated with sulforaphane (SF; 1.0 & 5.0 muM) to activate Nrf2/antioxidant signaling during proliferation and differentiation (i.e. formation of myotubes/myofibers).	sulforaphane	54-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
32361680-5	2020	Satellite cell-like C2C12 myoblasts were treated with sulforaphane (SF; 1.0 & 5.0 muM) to activate Nrf2/antioxidant signaling during proliferation and differentiation (i.e. formation of myotubes/myofibers).	sulforaphane	68-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
32545803-5	2020	SFN treatment modulates redox balance via activating redox regulator nuclear factor E2 factor-related factor (Nrf2).	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114
32416107-9	2020	Furthermore, after activation of Nrf2 by sulforaphane, sperm concentration and motility in busulfan-treated mice increased, accompanied by enhanced expressions of GPX4 and FPN1.	sulforaphane	41-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
32416107-9	2020	Furthermore, after activation of Nrf2 by sulforaphane, sperm concentration and motility in busulfan-treated mice increased, accompanied by enhanced expressions of GPX4 and FPN1.	sulforaphane	41-53	glutathione peroxidase 4	Mus musculus	163-167
32844924-4	2020	The expression of Nrf2 was interfered with using sulforaphane (SFN); for that end, three groups were established: a blank group (H2O2-/SFN-), control group (H2O2+/SFN-), and an experimental group (H2O2+/SFN+).	sulforaphane	49-61	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
32844924-4	2020	The expression of Nrf2 was interfered with using sulforaphane (SFN); for that end, three groups were established: a blank group (H2O2-/SFN-), control group (H2O2+/SFN-), and an experimental group (H2O2+/SFN+).	sulforaphane	63-66	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
32521810-4	2020	The antioxidant curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-2,5-dione], glycosinolate of sulforaphane (broccoli) or AFA (Aphanizomenon flos) extract promote beneficial effects in patients.	sulforaphane	105-117	AFA	Homo sapiens	132-135
32641994-8	2020	Additionally, Nrf2 levels significantly increased and negatively correlated with TLR4 and IRF1 levels in a mouse model of CaOx nephrocalcinosis following sulforaphane treatment.	sulforaphane	154-166	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
32587657-13	2020	Follow-up experiments confirmed that proteasome activity was lower in old cells than in young cells and that upregulation of Slc7a11 expression by sulforaphane restored this activity.	sulforaphane	147-159	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	125-132
32641994-8	2020	Additionally, Nrf2 levels significantly increased and negatively correlated with TLR4 and IRF1 levels in a mouse model of CaOx nephrocalcinosis following sulforaphane treatment.	sulforaphane	154-166	toll-like receptor 4	Mus musculus	81-85
32641994-8	2020	Additionally, Nrf2 levels significantly increased and negatively correlated with TLR4 and IRF1 levels in a mouse model of CaOx nephrocalcinosis following sulforaphane treatment.	sulforaphane	154-166	interferon regulatory factor 1	Mus musculus	90-94
32512849-0	2020	Chronic Sulforaphane Administration Inhibits Resistance to the mTOR-Inhibitor Everolimus in Bladder Cancer Cells.	sulforaphane	8-20	mechanistic target of rapamycin kinase	Homo sapiens	63-67
32512849-14	2020	Therefore, sulforaphane may hold potential for treating bladder carcinoma in patients with resistance to an mTOR inhibitor.	sulforaphane	11-23	mechanistic target of rapamycin kinase	Homo sapiens	108-112
32641994-13	2020	Conclusions: The results suggested that sulforaphane might promote M2Mphi polarization and inhibit CaOx nephrocalcinosis-induced inflammatory injury to renal tubular epithelial cells via the Nrf2-miR-93-TLR4/IRF1 pathway in vitro and in vivo.	sulforaphane	40-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	191-195
32641994-13	2020	Conclusions: The results suggested that sulforaphane might promote M2Mphi polarization and inhibit CaOx nephrocalcinosis-induced inflammatory injury to renal tubular epithelial cells via the Nrf2-miR-93-TLR4/IRF1 pathway in vitro and in vivo.	sulforaphane	40-52	microRNA 9-3	Mus musculus	196-202
32641994-13	2020	Conclusions: The results suggested that sulforaphane might promote M2Mphi polarization and inhibit CaOx nephrocalcinosis-induced inflammatory injury to renal tubular epithelial cells via the Nrf2-miR-93-TLR4/IRF1 pathway in vitro and in vivo.	sulforaphane	40-52	toll-like receptor 4	Mus musculus	203-207
32641994-13	2020	Conclusions: The results suggested that sulforaphane might promote M2Mphi polarization and inhibit CaOx nephrocalcinosis-induced inflammatory injury to renal tubular epithelial cells via the Nrf2-miR-93-TLR4/IRF1 pathway in vitro and in vivo.	sulforaphane	40-52	interferon regulatory factor 1	Mus musculus	208-212
32581555-0	2020	Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo.	sulforaphane	16-28	AKT serine/threonine kinase 1	Homo sapiens	142-145
32492957-5	2020	Sulforaphane, a hydrophilic but strict Keap1/Nrf2 pathway enhancer, did not show any effect either.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	39-44
31760092-4	2020	Herein, based on the skeleton of resveratrol, trans-4,4"-dihydroxystilbene (DHS) has been firstly identified to be an Nrf2 activator, which is more potent than the well-known sulforaphane (SF) and resveratrol.	sulforaphane	189-191	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
32472077-0	2020	Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.	sulforaphane	43-55	signal transducer and activator of transcription 3	Homo sapiens	10-15
32472077-0	2020	Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer.	sulforaphane	43-55	estrogen receptor 1	Homo sapiens	113-115
32472077-3	2020	Here we investigate SFX-01, a stabilised formulation of sulforaphane (SFN), for its effects on breast CSC activity in ER+ preclinical models.	sulforaphane	56-68	estrogen receptor 1	Homo sapiens	118-120
32472077-3	2020	Here we investigate SFX-01, a stabilised formulation of sulforaphane (SFN), for its effects on breast CSC activity in ER+ preclinical models.	sulforaphane	70-73	estrogen receptor 1	Homo sapiens	118-120
32061629-12	2020	New experimental results are provided demonstrating that post-ischemic administration of the Nrf2 activator sulforaphane protects against hippocampal neuronal death and neurologic injury in a clinically-relevant animal model of cardiac arrest and resuscitation.	sulforaphane	108-120	NFE2 like bZIP transcription factor 2	Homo sapiens	93-97
32429039-6	2020	Among 6659 differentially regulated microRNAs, miR29b-1-5p, and miR-27b-5p were downregulated by sulforaphane compared to controls, but upregulated by SF102 and SF134 compared to sulforaphane, suggesting differential signaling.	sulforaphane	97-109	microRNA 29b-1	Gallus gallus	47-55
32443471-0	2020	Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.	sulforaphane	87-99	AKT serine/threonine kinase 1	Homo sapiens	40-43
32443471-0	2020	Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.	sulforaphane	87-99	mechanistic target of rapamycin kinase	Homo sapiens	45-49
32443471-0	2020	Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer.	sulforaphane	87-99	mitogen-activated protein kinase 1	Homo sapiens	55-58
32443471-4	2020	Inhibition of anchorage-independent growth, invasion, and migration of the cell lines was associated with sulforaphane-induced alterations in epithelial-to-mesenchymal transition (EMT) markers of increased E-cadherin and decreased N-cadherin and vimentin expression.	sulforaphane	106-118	cadherin 1	Homo sapiens	206-216
32443471-4	2020	Inhibition of anchorage-independent growth, invasion, and migration of the cell lines was associated with sulforaphane-induced alterations in epithelial-to-mesenchymal transition (EMT) markers of increased E-cadherin and decreased N-cadherin and vimentin expression.	sulforaphane	106-118	cadherin 2	Homo sapiens	231-241
32443471-4	2020	Inhibition of anchorage-independent growth, invasion, and migration of the cell lines was associated with sulforaphane-induced alterations in epithelial-to-mesenchymal transition (EMT) markers of increased E-cadherin and decreased N-cadherin and vimentin expression.	sulforaphane	106-118	vimentin	Homo sapiens	246-254
32443471-5	2020	Proteomic analysis identified alterations in AKT, mTOR, and ERK kinases in the networks of sulforaphane effects in the Ishikawa endometrial cancer cell line.	sulforaphane	91-103	AKT serine/threonine kinase 1	Homo sapiens	45-48
32443471-5	2020	Proteomic analysis identified alterations in AKT, mTOR, and ERK kinases in the networks of sulforaphane effects in the Ishikawa endometrial cancer cell line.	sulforaphane	91-103	mechanistic target of rapamycin kinase	Homo sapiens	50-54
32443471-5	2020	Proteomic analysis identified alterations in AKT, mTOR, and ERK kinases in the networks of sulforaphane effects in the Ishikawa endometrial cancer cell line.	sulforaphane	91-103	mitogen-activated protein kinase 1	Homo sapiens	60-63
32443471-6	2020	Western blots confirmed sulforaphane inhibition of AKT, mTOR, and induction of ERK with alterations in downstream signaling.	sulforaphane	24-36	AKT serine/threonine kinase 1	Homo sapiens	51-54
32443471-6	2020	Western blots confirmed sulforaphane inhibition of AKT, mTOR, and induction of ERK with alterations in downstream signaling.	sulforaphane	24-36	mechanistic target of rapamycin kinase	Homo sapiens	56-60
32443471-6	2020	Western blots confirmed sulforaphane inhibition of AKT, mTOR, and induction of ERK with alterations in downstream signaling.	sulforaphane	24-36	mitogen-activated protein kinase 1	Homo sapiens	79-82
32443471-7	2020	AKT and mTOR inhibitors reduced endometrial cancer cell line viability and prevented further reduction by sulforaphane.	sulforaphane	106-118	AKT serine/threonine kinase 1	Homo sapiens	0-3
32443471-7	2020	AKT and mTOR inhibitors reduced endometrial cancer cell line viability and prevented further reduction by sulforaphane.	sulforaphane	106-118	mechanistic target of rapamycin kinase	Homo sapiens	8-12
32443471-8	2020	Accumulation of nuclear phosphorylated ERK was associated with reduced sensitivity to the ERK inhibitor and its interference with sulforaphane activity.	sulforaphane	130-142	mitogen-activated protein kinase 1	Homo sapiens	39-42
32443471-8	2020	Accumulation of nuclear phosphorylated ERK was associated with reduced sensitivity to the ERK inhibitor and its interference with sulforaphane activity.	sulforaphane	130-142	mitogen-activated protein kinase 1	Homo sapiens	90-93
32443471-10	2020	These results verify sulforaphane"s potential as a non-toxic treatment candidate for endometrial cancer and identify AKT, mTOR, and ERK kinases in the mechanism of action with interference in the mechanism by nuclear phosphorylated ERK.	sulforaphane	21-33	AKT serine/threonine kinase 1	Homo sapiens	117-120
32443471-10	2020	These results verify sulforaphane"s potential as a non-toxic treatment candidate for endometrial cancer and identify AKT, mTOR, and ERK kinases in the mechanism of action with interference in the mechanism by nuclear phosphorylated ERK.	sulforaphane	21-33	mechanistic target of rapamycin kinase	Homo sapiens	122-126
32443471-10	2020	These results verify sulforaphane"s potential as a non-toxic treatment candidate for endometrial cancer and identify AKT, mTOR, and ERK kinases in the mechanism of action with interference in the mechanism by nuclear phosphorylated ERK.	sulforaphane	21-33	mitogen-activated protein kinase 1	Homo sapiens	132-135
32443471-10	2020	These results verify sulforaphane"s potential as a non-toxic treatment candidate for endometrial cancer and identify AKT, mTOR, and ERK kinases in the mechanism of action with interference in the mechanism by nuclear phosphorylated ERK.	sulforaphane	21-33	mitogen-activated protein kinase 1	Homo sapiens	232-235
32429039-6	2020	Among 6659 differentially regulated microRNAs, miR29b-1-5p, and miR-27b-5p were downregulated by sulforaphane compared to controls, but upregulated by SF102 and SF134 compared to sulforaphane, suggesting differential signaling.	sulforaphane	97-109	microRNA 27b	Gallus gallus	64-71
32185415-9	2020	In contrast, Mdr1a induction was suppressed after pregnane X receptor (PXR) inhibition by sulforaphane and knockdown of this nuclear receptor.	sulforaphane	90-102	ATP binding cassette subfamily B member 1A	Rattus norvegicus	13-18
31769924-6	2020	Sulforaphane was used as an Nrf2 agonist.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
31769924-13	2020	In WT animals, Sulforaphane successfully augmented all the protective effects of Nrf2 with increase of SOD2 activity.	sulforaphane	15-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
31769924-13	2020	In WT animals, Sulforaphane successfully augmented all the protective effects of Nrf2 with increase of SOD2 activity.	sulforaphane	15-27	superoxide dismutase 2, mitochondrial	Mus musculus	103-107
32185415-9	2020	In contrast, Mdr1a induction was suppressed after pregnane X receptor (PXR) inhibition by sulforaphane and knockdown of this nuclear receptor.	sulforaphane	90-102	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	50-69
32185415-9	2020	In contrast, Mdr1a induction was suppressed after pregnane X receptor (PXR) inhibition by sulforaphane and knockdown of this nuclear receptor.	sulforaphane	90-102	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	71-74
31957488-3	2020	Moreover, SFN treatment blunted Ang II-stimulated oxidative stress and mitochondria-related apoptosis in HUVECs.	sulforaphane	10-13	angiotensinogen	Homo sapiens	32-38
31957488-5	2020	SFN induced nuclear factor erythroid 2 (Nrf2) activation and expression in Ang II-stimulated HUVECs.	sulforaphane	0-3	nuclear factor, erythroid 2	Homo sapiens	12-38
31957488-0	2020	Sulforaphane attenuates angiotensin II-induced human umbilical vein endothelial cell injury by modulating ROS-mediated mitochondrial signaling.	sulforaphane	0-12	angiotensinogen	Homo sapiens	24-38
31957488-1	2020	The study aimed to investigate whether sulforaphane (SFN) protects against angiotensin II (Ang II)-mediated human umbilical vein endothelial cell (HUVEC) injury.	sulforaphane	39-51	angiotensinogen	Homo sapiens	75-89
31957488-1	2020	The study aimed to investigate whether sulforaphane (SFN) protects against angiotensin II (Ang II)-mediated human umbilical vein endothelial cell (HUVEC) injury.	sulforaphane	39-51	angiotensinogen	Homo sapiens	91-97
31957488-5	2020	SFN induced nuclear factor erythroid 2 (Nrf2) activation and expression in Ang II-stimulated HUVECs.	sulforaphane	0-3	nuclear factor, erythroid 2	Homo sapiens	40-44
31957488-1	2020	The study aimed to investigate whether sulforaphane (SFN) protects against angiotensin II (Ang II)-mediated human umbilical vein endothelial cell (HUVEC) injury.	sulforaphane	53-56	angiotensinogen	Homo sapiens	75-89
31957488-1	2020	The study aimed to investigate whether sulforaphane (SFN) protects against angiotensin II (Ang II)-mediated human umbilical vein endothelial cell (HUVEC) injury.	sulforaphane	53-56	angiotensinogen	Homo sapiens	91-97
31957488-5	2020	SFN induced nuclear factor erythroid 2 (Nrf2) activation and expression in Ang II-stimulated HUVECs.	sulforaphane	0-3	angiotensinogen	Homo sapiens	75-81
31957488-6	2020	Downregulation of Nrf2 expression by a target-specific siRNA revealed an Nrf2-dependent effect on the SFN-mediated attenuation of Ang II-induced apoptosis in HUVECs.	sulforaphane	102-105	nuclear factor, erythroid 2	Homo sapiens	18-22
31957488-6	2020	Downregulation of Nrf2 expression by a target-specific siRNA revealed an Nrf2-dependent effect on the SFN-mediated attenuation of Ang II-induced apoptosis in HUVECs.	sulforaphane	102-105	nuclear factor, erythroid 2	Homo sapiens	73-77
31957488-6	2020	Downregulation of Nrf2 expression by a target-specific siRNA revealed an Nrf2-dependent effect on the SFN-mediated attenuation of Ang II-induced apoptosis in HUVECs.	sulforaphane	102-105	angiotensinogen	Homo sapiens	130-136
31957488-7	2020	Pretreatment with brusatol, an Nrf2-specific inhibitor, reversed the protective effects of SFN on Ang II-induced HUVEC injury.	sulforaphane	91-94	nuclear factor, erythroid 2	Homo sapiens	31-35
31957488-7	2020	Pretreatment with brusatol, an Nrf2-specific inhibitor, reversed the protective effects of SFN on Ang II-induced HUVEC injury.	sulforaphane	91-94	angiotensinogen	Homo sapiens	98-104
31957488-8	2020	SFN treatment protected HUVECs from Ang II-induced damage by decreasing oxidative stress and ameliorating mitochondrial injury.	sulforaphane	0-3	angiotensinogen	Homo sapiens	36-42
32073640-10	2020	Interestingly, sulforaphane treatment led to amelioration of TCE-mediated effects, resulting in Nrf2 activation and reduction in inflammatory and autoimmune responses.	sulforaphane	15-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
32184225-8	2020	In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNMTs and HDACs in ERalpha-negative breast cancer cell lines.	sulforaphane	26-38	black spleen	Mus musculus	13-16
32184225-8	2020	In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNMTs and HDACs in ERalpha-negative breast cancer cell lines.	sulforaphane	26-38	cyclin dependent kinase inhibitor 2A	Mus musculus	114-117
32184225-8	2020	In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNMTs and HDACs in ERalpha-negative breast cancer cell lines.	sulforaphane	26-38	transformation related protein 53, pseudogene	Mus musculus	122-125
32184225-8	2020	In addition, BSp-enriched sulforaphane was shown to increase protein expression of tumor suppressor genes such as p16 and p53 and inhibit the protein levels of Bmi1, DNMTs and HDACs in ERalpha-negative breast cancer cell lines.	sulforaphane	26-38	Bmi1 polycomb ring finger oncogene	Mus musculus	160-164
32073640-12	2020	Attenuation of TCE-mediated autoimmunity via activation of Nrf2 supports that antioxidants sulforaphane/tBHQ could be potential therapeutic agents for autoimmune diseases.	sulforaphane	91-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
32108526-2	2020	Sulforaphane (SFN), a potent Nrf2 activator, has significant anti-inflammatory effects and facilitates cardiac protection in preclinical diabetic models.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
32017935-6	2020	The aim of this review is to provide the newest insights in the preclinical and clinical evidence of Nrf2 induction in the regeneration of the antioxidant response and attenuation of inflammation in MS. Preclinical studies have indicated that activators of this pathway, such as epigallocatechin gallate (EGCG), curcumin, melatonin, resveratrol, and sulforaphane might be a promising therapeutic option in amelioration of MS symptoms, nevertheless, the efficacy and safety of these compounds have to be confirmed in future clinical trials.	sulforaphane	350-362	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
32365761-0	2020	Cell Death Effects Induced by Sulforaphane and Allyl Isothiocyanate on P-Glycoprotein Positive and Negative Variants in L1210 Cells.	sulforaphane	30-42	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
32108526-2	2020	Sulforaphane (SFN), a potent Nrf2 activator, has significant anti-inflammatory effects and facilitates cardiac protection in preclinical diabetic models.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
32108526-8	2020	SFN prevented SuHx-induced RV dysfunction and remodeling, reduced RV inflammation and fibrosis, upregulated Nrf2 expression and its downstream gene NQO1, and reduced the inflammatory mediator leucine-rich repeat and pyrin domain-containing 3 (NLRP3).	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
32108526-8	2020	SFN prevented SuHx-induced RV dysfunction and remodeling, reduced RV inflammation and fibrosis, upregulated Nrf2 expression and its downstream gene NQO1, and reduced the inflammatory mediator leucine-rich repeat and pyrin domain-containing 3 (NLRP3).	sulforaphane	0-3	NAD(P)H dehydrogenase, quinone 1	Mus musculus	148-152
32108526-8	2020	SFN prevented SuHx-induced RV dysfunction and remodeling, reduced RV inflammation and fibrosis, upregulated Nrf2 expression and its downstream gene NQO1, and reduced the inflammatory mediator leucine-rich repeat and pyrin domain-containing 3 (NLRP3).	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	243-248
32108526-14	2020	Sulforaphane (SFN) attenuates or prevents the RV and lung injury in the SUF5416 + hypoxia model of PAH, suggesting that Nrf2 may be a candidate target for strategies to prevent or reverse PAH.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
32108526-14	2020	Sulforaphane (SFN) attenuates or prevents the RV and lung injury in the SUF5416 + hypoxia model of PAH, suggesting that Nrf2 may be a candidate target for strategies to prevent or reverse PAH.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
31884211-0	2020	Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3beta/Fyn pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	81-84
31884211-0	2020	Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3beta/Fyn pathway.	sulforaphane	0-12	glycogen synthase kinase 3 beta	Rattus norvegicus	85-94
31884211-0	2020	Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3beta/Fyn pathway.	sulforaphane	0-12	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	95-98
32097704-10	2020	Sulforaphane also inhibited ectopic endometrial tissue growth in sciatic endometriosis rat, shown as the shrinkage of lesion size and decreased VEGF levels.	sulforaphane	0-12	vascular endothelial growth factor A	Rattus norvegicus	144-148
31884211-5	2020	The results showed that SFN prevented Cr-induced oxidative stress, histopathological lesions, inflammation, apoptosis, and changes in protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3beta) levels in vivo and in vitro.	sulforaphane	24-27	AKT serine/threonine kinase 1	Rattus norvegicus	152-155
31884211-5	2020	The results showed that SFN prevented Cr-induced oxidative stress, histopathological lesions, inflammation, apoptosis, and changes in protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3beta) levels in vivo and in vitro.	sulforaphane	24-27	glycogen synthase kinase 3 beta	Rattus norvegicus	161-192
31884211-5	2020	The results showed that SFN prevented Cr-induced oxidative stress, histopathological lesions, inflammation, apoptosis, and changes in protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3beta) levels in vivo and in vitro.	sulforaphane	24-27	glycogen synthase kinase 3 beta	Rattus norvegicus	194-203
31884211-7	2020	Furthermore, SFN increased the expression of nuclear factor-E2-related factor-2 (Nrf2) phase II detoxification enzymes.	sulforaphane	13-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	81-85
31884211-8	2020	Collectively, this study demonstrates that SFN prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3beta/Fyn signaling pathway.	sulforaphane	43-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
31884211-8	2020	Collectively, this study demonstrates that SFN prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3beta/Fyn signaling pathway.	sulforaphane	43-46	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
31884211-8	2020	Collectively, this study demonstrates that SFN prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3beta/Fyn signaling pathway.	sulforaphane	43-46	glycogen synthase kinase 3 beta	Rattus norvegicus	183-192
31884211-8	2020	Collectively, this study demonstrates that SFN prevents K2Cr2O7-induced lung toxicity in rats through enhancing Nrf2-mediated exogenous antioxidant defenses via activation of the Akt/GSK-3beta/Fyn signaling pathway.	sulforaphane	43-46	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	193-196
32041439-6	2020	Binding mode of sulforaphane within caspase-1 was determined by molecular docking simulation.	sulforaphane	16-28	caspase 1	Homo sapiens	36-45
32041439-9	2020	In the molecular docking simulation and in vitro caspase-1 assays, sulforaphane regulated caspase-1 activity by docking with the identical binding site of caspase-1.	sulforaphane	67-79	caspase 1	Homo sapiens	49-58
32041439-9	2020	In the molecular docking simulation and in vitro caspase-1 assays, sulforaphane regulated caspase-1 activity by docking with the identical binding site of caspase-1.	sulforaphane	67-79	caspase 1	Homo sapiens	90-99
32041439-9	2020	In the molecular docking simulation and in vitro caspase-1 assays, sulforaphane regulated caspase-1 activity by docking with the identical binding site of caspase-1.	sulforaphane	67-79	caspase 1	Homo sapiens	90-99
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	thymic stromal lymphopoietin	Homo sapiens	84-88
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	tumor necrosis factor	Homo sapiens	90-123
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	interleukin 1 alpha	Homo sapiens	125-147
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	interleukin 6	Homo sapiens	149-153
32041439-10	2020	Sulforaphane significantly inhibited the levels of inflammatory mediators including TSLP, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, and IL-8 in a dose-dependent manner.	sulforaphane	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	159-163
32041439-11	2020	Immunoblotting experiments revealed that sulforaphane and WE reduced translocation of NF-kappaBp65 into the nucleus and phosphorylation of IkappaBalpha in the cytosol.	sulforaphane	41-53	RELA proto-oncogene, NF-kB subunit	Homo sapiens	86-98
32041439-11	2020	Immunoblotting experiments revealed that sulforaphane and WE reduced translocation of NF-kappaBp65 into the nucleus and phosphorylation of IkappaBalpha in the cytosol.	sulforaphane	41-53	NFKB inhibitor alpha	Homo sapiens	139-151
32041439-12	2020	Furthermore, phosphorylation of mitogen-activated protein kinases (MAPK) was down-regulated by treatment with sulforaphane or WE.Conclusion: Our findings suggest that sulforaphane and WE have anti-allergic inflammatory effects by intercepting caspase-1/NF-kappaB/MAPKs signaling pathways.	sulforaphane	110-122	caspase 1	Homo sapiens	243-252
32041439-12	2020	Furthermore, phosphorylation of mitogen-activated protein kinases (MAPK) was down-regulated by treatment with sulforaphane or WE.Conclusion: Our findings suggest that sulforaphane and WE have anti-allergic inflammatory effects by intercepting caspase-1/NF-kappaB/MAPKs signaling pathways.	sulforaphane	110-122	nuclear factor kappa B subunit 1	Homo sapiens	253-262
32041439-12	2020	Furthermore, phosphorylation of mitogen-activated protein kinases (MAPK) was down-regulated by treatment with sulforaphane or WE.Conclusion: Our findings suggest that sulforaphane and WE have anti-allergic inflammatory effects by intercepting caspase-1/NF-kappaB/MAPKs signaling pathways.	sulforaphane	167-179	caspase 1	Homo sapiens	243-252
32041439-12	2020	Furthermore, phosphorylation of mitogen-activated protein kinases (MAPK) was down-regulated by treatment with sulforaphane or WE.Conclusion: Our findings suggest that sulforaphane and WE have anti-allergic inflammatory effects by intercepting caspase-1/NF-kappaB/MAPKs signaling pathways.	sulforaphane	167-179	nuclear factor kappa B subunit 1	Homo sapiens	253-262
32097704-11	2020	IL6, IL-1beta and TNF-alpha levels were decreased by sulforaphane.	sulforaphane	53-65	interleukin 6	Rattus norvegicus	0-3
32097704-11	2020	IL6, IL-1beta and TNF-alpha levels were decreased by sulforaphane.	sulforaphane	53-65	interleukin 1 alpha	Rattus norvegicus	5-13
32097704-11	2020	IL6, IL-1beta and TNF-alpha levels were decreased by sulforaphane.	sulforaphane	53-65	tumor necrosis factor	Rattus norvegicus	18-27
32097704-12	2020	Sulforaphane induced DOX2 and INOS suppression and Keap1 and Nrf2 upregulation.	sulforaphane	0-12	nitric oxide synthase 2	Rattus norvegicus	30-34
32097704-12	2020	Sulforaphane induced DOX2 and INOS suppression and Keap1 and Nrf2 upregulation.	sulforaphane	0-12	Kelch-like ECH-associated protein 1	Rattus norvegicus	51-56
32097704-12	2020	Sulforaphane induced DOX2 and INOS suppression and Keap1 and Nrf2 upregulation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	61-65
32217557-2	2020	Despite huge advances in techniques to secure the aneurysm, there has been little progress in the treatment of the deleterious effects of the haemorrhage.Sulforaphane is an Nrf2 inducer with anti-oxidant and anti-inflammatory properties.	sulforaphane	154-166	NFE2 like bZIP transcription factor 2	Homo sapiens	173-177
32323779-0	2020	Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2-UDP glucuronosyltransferase 1A metabolic axis activation.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	72-75
32323779-0	2020	Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2-UDP glucuronosyltransferase 1A metabolic axis activation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
32323779-0	2020	Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2-UDP glucuronosyltransferase 1A metabolic axis activation.	sulforaphane	0-12	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	81-111
31838078-0	2020	Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization.	sulforaphane	10-22	lymphocyte antigen 96	Homo sapiens	100-116
32323779-10	2020	Reverse transcription-quantitative polymerase chain reaction and western blotting were employed to verify the role of Nrf2 in SFN-induced UGT1A.	sulforaphane	126-129	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
32323779-10	2020	Reverse transcription-quantitative polymerase chain reaction and western blotting were employed to verify the role of Nrf2 in SFN-induced UGT1A.	sulforaphane	126-129	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	138-143
31945311-4	2020	Sulforaphane, an isothiocyanate derived from cruciferous vegetables and a known activator of the Nrf2 pathway, was used to validate the reporter system.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
32521892-0	2020	Sulforaphane exerts anticancer effects on human liver cancer cells via induction of apoptosis and inhibition of migration and invasion by targeting MAPK7 signalling pathway.	sulforaphane	0-12	mitogen-activated protein kinase 7	Homo sapiens	148-153
32521892-10	2020	DAPI staining revealed that Sulforaphane triggered the apoptotic cell death of HepG2 cells which was accompanied with activation of caspases 3 and 9, upregulation of Bax and downregulation of Bcl-2.	sulforaphane	28-40	caspase 3	Homo sapiens	132-148
32521892-10	2020	DAPI staining revealed that Sulforaphane triggered the apoptotic cell death of HepG2 cells which was accompanied with activation of caspases 3 and 9, upregulation of Bax and downregulation of Bcl-2.	sulforaphane	28-40	BCL2 associated X, apoptosis regulator	Homo sapiens	166-169
32521892-10	2020	DAPI staining revealed that Sulforaphane triggered the apoptotic cell death of HepG2 cells which was accompanied with activation of caspases 3 and 9, upregulation of Bax and downregulation of Bcl-2.	sulforaphane	28-40	BCL2 apoptosis regulator	Homo sapiens	192-197
32521892-12	2020	The effects of Sulforaphane were also investigated on the MAPK7 signalling pathway and it was found that Sulforaphane could block this pathway in HepG2 cells.	sulforaphane	105-117	mitogen-activated protein kinase 7	Homo sapiens	58-63
31884317-6	2020	Further, sulforaphane (SFN) was utilized as an Nrf2 activator to assess its effect on above said inflammatory and nitrative stress parameters.	sulforaphane	9-21	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
31884317-6	2020	Further, sulforaphane (SFN) was utilized as an Nrf2 activator to assess its effect on above said inflammatory and nitrative stress parameters.	sulforaphane	23-26	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
31884317-9	2020	However, activation of Nrf2 in vitro by SFN reverses LPS-induced effects on inflammation in monocytes by reduction in NFkB signaling.	sulforaphane	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
32024151-4	2020	Using both ascorbic acid (AA, also known as vitamin C) and sulforaphane (SFN), an inducer of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), we tested the hypothesis that dietary antioxidants can mitigate HALI by ameliorating HMGB1-compromised macrophage function in phagocytosis by attenuating hyperoxia-induced extracellular HMGB1 accumulation.	sulforaphane	59-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
32024151-4	2020	Using both ascorbic acid (AA, also known as vitamin C) and sulforaphane (SFN), an inducer of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), we tested the hypothesis that dietary antioxidants can mitigate HALI by ameliorating HMGB1-compromised macrophage function in phagocytosis by attenuating hyperoxia-induced extracellular HMGB1 accumulation.	sulforaphane	73-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
32024151-11	2020	Our study is the first to report that the dietary antioxidants, ascorbic acid and sulforaphane, ameliorate HALI and attenuate hyperoxia-induced macrophage dysfunction through an HMGB1-mediated pathway.	sulforaphane	82-94	high mobility group box 1	Mus musculus	178-183
31784171-0	2020	Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders.	sulforaphane	20-32	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
31784171-6	2020	Nrf2 is one of the most crucial targets of sulforaphane which has potential in regulating the series of cytoprotective enzyme expressions that have neuroprotective, antioxidative, and detoxification actions.	sulforaphane	43-55	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31784171-8	2020	Sulforaphane protects various neurological disorders by regulating the Nrf2 pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
31784171-9	2020	In this article, we recapitulate current studies of sulforaphane-mediated Nrf2 activation in the treatment of various neurological disorders.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
31421134-2	2020	This is because natural compounds such as sulforaphane, which is found in broccoli sprout extracts, can activate Nrf2.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	113-117
31982468-0	2020	Sulforaphane Attenuates Abeta Oligomers Mediated Decrease in Phagocytic Activity of Microglial Cells.	sulforaphane	0-12	amyloid beta precursor protein	Homo sapiens	24-29
32111854-5	2020	The autophagy inhibitor bafilomycin caused a significant decrease in the production of Nrf2, HO-1 and NQO1 compared to DEPs treatment, whereas the Nrf2 activator sulforaphane increased the LC3B (p = 0.020) levels.	sulforaphane	162-174	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
32111854-5	2020	The autophagy inhibitor bafilomycin caused a significant decrease in the production of Nrf2, HO-1 and NQO1 compared to DEPs treatment, whereas the Nrf2 activator sulforaphane increased the LC3B (p = 0.020) levels.	sulforaphane	162-174	microtubule associated protein 1 light chain 3 beta	Homo sapiens	189-193
32033211-12	2020	Collectively, SFN may protect the liver from exhaustive exercise-induced inflammation via inducing antioxidant defense response through the activation of Nrf2/HO-1 signal transduction pathway.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	154-158
32033211-12	2020	Collectively, SFN may protect the liver from exhaustive exercise-induced inflammation via inducing antioxidant defense response through the activation of Nrf2/HO-1 signal transduction pathway.	sulforaphane	14-17	heme oxygenase 1	Mus musculus	159-163
31838078-3	2020	Compound ITH12674 is a melatonin-sulforaphane hybrid designed to exert a dual drug-prodrug mechanism of action that combines potent NRF2 induction and free radical scavenger activity.	sulforaphane	33-45	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
31918259-5	2020	Genetic knock-down of NRF2 decreased, while NRF2 overexpression or chemical activation with sulforaphane, increased TAZ transcript and protein levels.	sulforaphane	92-104	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
31846091-0	2020	Histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human breast cancer cells.	sulforaphane	85-97	histone deacetylase 9	Homo sapiens	0-19
31846091-3	2020	METHODS: This study employed a combinatorial chemopreventive strategy to investigate the impact of dietary histone deacetylase (HDAC) inhibitor, that is, sulforaphane on chromatin remodeling in BC.	sulforaphane	154-166	histone deacetylase 9	Homo sapiens	107-126
31846091-3	2020	METHODS: This study employed a combinatorial chemopreventive strategy to investigate the impact of dietary histone deacetylase (HDAC) inhibitor, that is, sulforaphane on chromatin remodeling in BC.	sulforaphane	154-166	histone deacetylase 9	Homo sapiens	128-132
31918259-5	2020	Genetic knock-down of NRF2 decreased, while NRF2 overexpression or chemical activation with sulforaphane, increased TAZ transcript and protein levels.	sulforaphane	92-104	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	116-119
33302269-2	2020	In a piglet model of HI that exhibits similar selective regional vulnerability, we tested the hypothesis that early treatment with sulforaphane, an activator of the Nrf2 transcription factor, protects vulnerable neurons from HI injury.	sulforaphane	131-143	NFE2 like bZIP transcription factor 2	Homo sapiens	165-169
31678166-0	2020	Inhibition of miR30a-3p by sulforaphane enhances gap junction intercellular communication in pancreatic cancer.	sulforaphane	27-39	microRNA 30a	Homo sapiens	14-20
31678166-5	2020	Sulforaphane inhibited the expression of our top candidate miR30a-3p.	sulforaphane	0-12	microRNA 30a	Homo sapiens	59-65
31900311-0	2020	Editor"s Note: Sulforaphane Enhances the Therapeutic Potential of TRAIL in Prostate Cancer Orthotopic Model through Regulation of Apoptosis, Metastasis, and Angiogenesis.	sulforaphane	15-27	TNF superfamily member 10	Homo sapiens	66-71
33302269-8	2020	Treatment with sulforaphane increased the nuclear Nrf2 and gamma-glu-tamylcysteine synthetase expression at 6 h of recovery in these regions.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
33302269-8	2020	Treatment with sulforaphane increased the nuclear Nrf2 and gamma-glu-tamylcysteine synthetase expression at 6 h of recovery in these regions.	sulforaphane	15-27	glutamate-cysteine ligase catalytic subunit	Homo sapiens	59-93
33302269-9	2020	We conclude that systemic administration of sulforaphane 15 min after HI can induce the translocation of Nrf2 to the nucleus, increase expression of an enzyme involved in glutathione synthesis, and salvage neurons in the highly vulnerable putamen and sensorimotor cortex in a large-animal model of HI.	sulforaphane	44-56	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
31232487-1	2020	BACKGROUND: Nuclear factor erythroid 2-related factor 2 (Nrf2) can alleviate diffuse axonal injury (DAI)-induced apoptosis by regulating expression of heme oxygenase-1 (HO-1), while sulforaphane (SFN) was shown to reduce oxidative stress by increasing the expression of Nrf2.	sulforaphane	196-199	heme oxygenase 1	Rattus norvegicus	151-167
32309226-0	2020	Sulforaphane Modulates Cell Migration and Expression of beta-Catenin and Epithelial Mesenchymal Transition Markers in Breast Cancer Cells.	sulforaphane	0-12	catenin beta 1	Homo sapiens	56-68
32309226-1	2020	Background: We aimed to assess the effect of sulforaphane (SFN) on breast cancer cell migration and also its effect on the expression of epithelial mesenchymal transition (EMT) markers and beta-catenin.	sulforaphane	45-57	catenin beta 1	Homo sapiens	189-201
32309226-1	2020	Background: We aimed to assess the effect of sulforaphane (SFN) on breast cancer cell migration and also its effect on the expression of epithelial mesenchymal transition (EMT) markers and beta-catenin.	sulforaphane	59-62	catenin beta 1	Homo sapiens	189-201
31727850-9	2020	Furthermore, supplementation with cruciferous broccoli powder rich in the precursor to antioxidant-activating sulforaphane significantly ameliorated kidney injury in Gstm1 knockout, but not wild-type mice.	sulforaphane	110-122	glutathione S-transferase, mu 1	Mus musculus	166-171
31232487-0	2020	Sulforaphane administration alleviates diffuse axonal injury (DAI) via regulation signaling pathway of NRF2 and HO-1.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-107
31232487-0	2020	Sulforaphane administration alleviates diffuse axonal injury (DAI) via regulation signaling pathway of NRF2 and HO-1.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	112-116
31232487-1	2020	BACKGROUND: Nuclear factor erythroid 2-related factor 2 (Nrf2) can alleviate diffuse axonal injury (DAI)-induced apoptosis by regulating expression of heme oxygenase-1 (HO-1), while sulforaphane (SFN) was shown to reduce oxidative stress by increasing the expression of Nrf2.	sulforaphane	182-194	NFE2 like bZIP transcription factor 2	Rattus norvegicus	12-55
31232487-10	2020	It is suspected that the protective effect of SFN was exerted via the activation of the Nrf2/HO-1 signaling pathway.	sulforaphane	46-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
31232487-1	2020	BACKGROUND: Nuclear factor erythroid 2-related factor 2 (Nrf2) can alleviate diffuse axonal injury (DAI)-induced apoptosis by regulating expression of heme oxygenase-1 (HO-1), while sulforaphane (SFN) was shown to reduce oxidative stress by increasing the expression of Nrf2.	sulforaphane	182-194	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
31232487-1	2020	BACKGROUND: Nuclear factor erythroid 2-related factor 2 (Nrf2) can alleviate diffuse axonal injury (DAI)-induced apoptosis by regulating expression of heme oxygenase-1 (HO-1), while sulforaphane (SFN) was shown to reduce oxidative stress by increasing the expression of Nrf2.	sulforaphane	196-199	NFE2 like bZIP transcription factor 2	Rattus norvegicus	12-55
31232487-10	2020	It is suspected that the protective effect of SFN was exerted via the activation of the Nrf2/HO-1 signaling pathway.	sulforaphane	46-49	heme oxygenase 1	Rattus norvegicus	93-97
31232487-1	2020	BACKGROUND: Nuclear factor erythroid 2-related factor 2 (Nrf2) can alleviate diffuse axonal injury (DAI)-induced apoptosis by regulating expression of heme oxygenase-1 (HO-1), while sulforaphane (SFN) was shown to reduce oxidative stress by increasing the expression of Nrf2.	sulforaphane	196-199	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
31706979-0	2020	Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function.	sulforaphane	22-34	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	81-85
32238698-6	2020	However, sulforaphane inhibited fibrinolytic activity and t-PA synthesis in EA.hy926 cells without any cell damage.	sulforaphane	9-21	plasminogen activator, tissue type	Homo sapiens	58-62
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	35-38	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	267-277
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	35-38	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	284-294
31706979-0	2020	Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	172-175	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	128-132
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	21-33	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	128-132
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	172-175	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	149-153
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	172-175	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	267-277
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	172-175	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	284-294
31706979-7	2020	Cardiac function was examined with echocardiography before sacrifice at both 3 M and 6 M. SFN prevented T2D-induced progression of cardiac dysfunction, remodeling (hypertrophy and fibrosis), inflammation, and oxidative damage in wild-type diabetic mice, but not in AMPKalpha2-KO mice.	sulforaphane	90-93	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	265-275
31706979-8	2020	Mechanistically, SFN prevented T2D-induced cardiomyopathy not only by improving AMPK-mediated lipid metabolic pathways, but also enhancing NRF2 activation via AMPK/AKT/GSK3beta pathway.	sulforaphane	17-20	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	80-84
31706979-8	2020	Mechanistically, SFN prevented T2D-induced cardiomyopathy not only by improving AMPK-mediated lipid metabolic pathways, but also enhancing NRF2 activation via AMPK/AKT/GSK3beta pathway.	sulforaphane	17-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	21-33	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	149-153
31706979-8	2020	Mechanistically, SFN prevented T2D-induced cardiomyopathy not only by improving AMPK-mediated lipid metabolic pathways, but also enhancing NRF2 activation via AMPK/AKT/GSK3beta pathway.	sulforaphane	17-20	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	159-163
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	21-33	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	267-277
31706979-8	2020	Mechanistically, SFN prevented T2D-induced cardiomyopathy not only by improving AMPK-mediated lipid metabolic pathways, but also enhancing NRF2 activation via AMPK/AKT/GSK3beta pathway.	sulforaphane	17-20	thymoma viral proto-oncogene 1	Mus musculus	164-167
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	21-33	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	284-294
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	35-38	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	128-132
31706979-8	2020	Mechanistically, SFN prevented T2D-induced cardiomyopathy not only by improving AMPK-mediated lipid metabolic pathways, but also enhancing NRF2 activation via AMPK/AKT/GSK3beta pathway.	sulforaphane	17-20	glycogen synthase kinase 3 beta	Mus musculus	168-176
31706979-9	2020	However, these improving effects of SFN were abolished in AMPKalpha2-KO diabetic mice.	sulforaphane	36-39	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	58-68
31706979-2	2020	It was reported that sulforaphane (SFN) prevented type 2 diabetes (T2D)-induced cardiomyopathy accompanied by the activation of AMPK; In this study, AMPK"s pivotal role in SFN-mediated prevention against T2D-induced cardiomyopathy was tested using global deletion of AMPKalpha2 gene (AMPKalpha2-KO) mice.	sulforaphane	35-38	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	149-153
31706979-10	2020	CONCLUSIONS: AMPK is indispensable for the SFN-induced prevention of cardiomyopathy in T2D, and the activation of NRF2 by SFN is mediated by AMPK/AKT/GSK3beta signaling pathways.	sulforaphane	43-46	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	13-17
32660825-2	2020	Sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, activates the redox-sensitive nuclear erythroid 2-related factor 2 (NRF2).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	104-140
31706979-10	2020	CONCLUSIONS: AMPK is indispensable for the SFN-induced prevention of cardiomyopathy in T2D, and the activation of NRF2 by SFN is mediated by AMPK/AKT/GSK3beta signaling pathways.	sulforaphane	122-125	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
31706979-10	2020	CONCLUSIONS: AMPK is indispensable for the SFN-induced prevention of cardiomyopathy in T2D, and the activation of NRF2 by SFN is mediated by AMPK/AKT/GSK3beta signaling pathways.	sulforaphane	122-125	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	141-145
31706979-10	2020	CONCLUSIONS: AMPK is indispensable for the SFN-induced prevention of cardiomyopathy in T2D, and the activation of NRF2 by SFN is mediated by AMPK/AKT/GSK3beta signaling pathways.	sulforaphane	122-125	thymoma viral proto-oncogene 1	Mus musculus	146-149
31706979-10	2020	CONCLUSIONS: AMPK is indispensable for the SFN-induced prevention of cardiomyopathy in T2D, and the activation of NRF2 by SFN is mediated by AMPK/AKT/GSK3beta signaling pathways.	sulforaphane	122-125	glycogen synthase kinase 3 beta	Mus musculus	150-158
32660825-2	2020	Sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, activates the redox-sensitive nuclear erythroid 2-related factor 2 (NRF2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	104-140
32660825-2	2020	Sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, activates the redox-sensitive nuclear erythroid 2-related factor 2 (NRF2).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
32660825-2	2020	Sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, activates the redox-sensitive nuclear erythroid 2-related factor 2 (NRF2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
31555797-3	2019	We have shown previously that prostate cancer prevention by sulforaphane (SFN) in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model is associated with inhibition of fatty acid metabolism.	sulforaphane	60-72	TNF receptor superfamily member 25	Homo sapiens	82-125
31474154-0	2020	Co-Treatment with Sulforaphane and Nano-Metformin Molecules Accelerates Apoptosis in HER2+ Breast Cancer Cells by Inhibiting Key Molecules.	sulforaphane	18-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-89
31555797-7	2019	Overexpression of c-Myc, but not constitutively active Akt, conferred protection against SFN-mediated downregulation of HKII and LDHA protein expression and suppression of lactate levels.	sulforaphane	89-92	lactate dehydrogenase A	Homo sapiens	129-133
31555797-3	2019	We have shown previously that prostate cancer prevention by sulforaphane (SFN) in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model is associated with inhibition of fatty acid metabolism.	sulforaphane	60-72	tumor necrosis factor receptor superfamily, member 25	Mus musculus	127-132
31555797-3	2019	We have shown previously that prostate cancer prevention by sulforaphane (SFN) in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model is associated with inhibition of fatty acid metabolism.	sulforaphane	74-77	TNF receptor superfamily member 25	Homo sapiens	82-125
31555797-3	2019	We have shown previously that prostate cancer prevention by sulforaphane (SFN) in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) model is associated with inhibition of fatty acid metabolism.	sulforaphane	74-77	tumor necrosis factor receptor superfamily, member 25	Mus musculus	127-132
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	hexokinase 2	Homo sapiens	170-183
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	hexokinase 2	Homo sapiens	185-189
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	pyruvate kinase M1/2	Homo sapiens	192-210
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	pyruvate kinase M1/2	Homo sapiens	212-216
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	lactate dehydrogenase A	Homo sapiens	226-249
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	lactate dehydrogenase A	Homo sapiens	251-255
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	TNF receptor superfamily member 25	Homo sapiens	328-333
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	341-344
31555797-5	2019	We found that SFN treatment: (a) decreased real-time extracellular acidification rate in LNCaP, but not in PC-3 cell line ; (b) significantly downregulated expression of hexokinase II (HKII), pyruvate kinase M2 (PKM2), and/or lactate dehydrogenase A (LDHA) in vitro in cells and in vivo in neoplastic lesions in the prostate of TRAMP and Hi-Myc mice; and (c) significantly suppressed glycolysis in prostate of Hi-Myc mice as measured by ex vivo1 H magnetic resonance spectroscopy.	sulforaphane	14-17	myelocytomatosis oncogene	Mus musculus	413-416
31555797-7	2019	Overexpression of c-Myc, but not constitutively active Akt, conferred protection against SFN-mediated downregulation of HKII and LDHA protein expression and suppression of lactate levels.	sulforaphane	89-92	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
31555797-7	2019	Overexpression of c-Myc, but not constitutively active Akt, conferred protection against SFN-mediated downregulation of HKII and LDHA protein expression and suppression of lactate levels.	sulforaphane	89-92	hexokinase 2	Homo sapiens	120-124
31766492-9	2019	SFN was able to prevent the expression of NO and cytokines through regulating inflammatory enzyme iNOS and activation of Nrf2/HO-1 signal transduction pathway.	sulforaphane	0-3	nitric oxide synthase 2, inducible	Mus musculus	98-102
31661135-4	2019	The effects of sulforaphane are considered to be mediated, in large part, through increased protein expression of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2).	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	139-182
31661135-4	2019	The effects of sulforaphane are considered to be mediated, in large part, through increased protein expression of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2).	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	184-188
31661135-7	2019	In the present analysis, HMOX1 and HSPA1A were identified as the most highly upregulated genes following sulforaphane treatment, suggesting their potential value as biomarkers to guide clinical trials.	sulforaphane	105-117	heme oxygenase 1	Homo sapiens	25-30
31661135-7	2019	In the present analysis, HMOX1 and HSPA1A were identified as the most highly upregulated genes following sulforaphane treatment, suggesting their potential value as biomarkers to guide clinical trials.	sulforaphane	105-117	heat shock protein family A (Hsp70) member 1A	Homo sapiens	35-41
31661135-8	2019	Sulforaphane induction of HMOX1 and HSPA1A was validated in vivo in murine tissues.	sulforaphane	0-12	heme oxygenase 1	Mus musculus	26-31
31661135-8	2019	Sulforaphane induction of HMOX1 and HSPA1A was validated in vivo in murine tissues.	sulforaphane	0-12	heat shock protein 1A	Mus musculus	36-42
31661135-9	2019	Furthermore, the impact of sulforaphane treatment of HNSCC cells on the expression levels of natural killer group 2D (NKG2D) and DNAX accessory molecule-1 (DNAM-1) ligands, which are activators of natural killer (NK) cells, was examined.	sulforaphane	27-39	killer cell lectin like receptor K1	Homo sapiens	93-116
31661135-9	2019	Furthermore, the impact of sulforaphane treatment of HNSCC cells on the expression levels of natural killer group 2D (NKG2D) and DNAX accessory molecule-1 (DNAM-1) ligands, which are activators of natural killer (NK) cells, was examined.	sulforaphane	27-39	killer cell lectin like receptor K1	Homo sapiens	118-123
31661135-9	2019	Furthermore, the impact of sulforaphane treatment of HNSCC cells on the expression levels of natural killer group 2D (NKG2D) and DNAX accessory molecule-1 (DNAM-1) ligands, which are activators of natural killer (NK) cells, was examined.	sulforaphane	27-39	CD226 molecule	Homo sapiens	129-154
31661135-9	2019	Furthermore, the impact of sulforaphane treatment of HNSCC cells on the expression levels of natural killer group 2D (NKG2D) and DNAX accessory molecule-1 (DNAM-1) ligands, which are activators of natural killer (NK) cells, was examined.	sulforaphane	27-39	CD226 molecule	Homo sapiens	156-162
31934264-2	2019	Sulforaphane-rich broccoli sprout extract (BSE) and zinc can effectively induce Nrf2 and metallothionein, respectively, to protect against IH-induced cardiomyopathy via antioxidative stress.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	80-84
31686558-1	2019	Context: Sulphoraphane (SFN) is an isothiocyanate, having antioxidant activity, antitumor, and therapeutic effects on cardiovascular disease.Objective: This study explores the mechanisms of SFN preconditioning on ischaemia/reperfusion injury (IRI).Materials and methods: Cardiomyocytes were divided into four groups as follows: control group (normoxic condition), SFN group (5 mumol/L), hypoxia/reoxygenation (H/R) group (1 h, 3 h) and SFN + H/R group.	sulforaphane	9-22	RNA exonuclease 2	Mus musculus	24-27
31686558-1	2019	Context: Sulphoraphane (SFN) is an isothiocyanate, having antioxidant activity, antitumor, and therapeutic effects on cardiovascular disease.Objective: This study explores the mechanisms of SFN preconditioning on ischaemia/reperfusion injury (IRI).Materials and methods: Cardiomyocytes were divided into four groups as follows: control group (normoxic condition), SFN group (5 mumol/L), hypoxia/reoxygenation (H/R) group (1 h, 3 h) and SFN + H/R group.	sulforaphane	9-22	RNA exonuclease 2	Mus musculus	190-193
31686558-1	2019	Context: Sulphoraphane (SFN) is an isothiocyanate, having antioxidant activity, antitumor, and therapeutic effects on cardiovascular disease.Objective: This study explores the mechanisms of SFN preconditioning on ischaemia/reperfusion injury (IRI).Materials and methods: Cardiomyocytes were divided into four groups as follows: control group (normoxic condition), SFN group (5 mumol/L), hypoxia/reoxygenation (H/R) group (1 h, 3 h) and SFN + H/R group.	sulforaphane	9-22	RNA exonuclease 2	Mus musculus	190-193
31686558-1	2019	Context: Sulphoraphane (SFN) is an isothiocyanate, having antioxidant activity, antitumor, and therapeutic effects on cardiovascular disease.Objective: This study explores the mechanisms of SFN preconditioning on ischaemia/reperfusion injury (IRI).Materials and methods: Cardiomyocytes were divided into four groups as follows: control group (normoxic condition), SFN group (5 mumol/L), hypoxia/reoxygenation (H/R) group (1 h, 3 h) and SFN + H/R group.	sulforaphane	9-22	RNA exonuclease 2	Mus musculus	190-193
31775341-8	2019	Sulforaphane and its precursor glucoraphanin are derived from broccoli sprouts and are the most potent natural Nrf2 inducers-they may protect mitochondrial function, thus suppressing the development of NASH.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
31766492-9	2019	SFN was able to prevent the expression of NO and cytokines through regulating inflammatory enzyme iNOS and activation of Nrf2/HO-1 signal transduction pathway.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
31408727-4	2019	Mimicking the effect of heme, the NRF2 agonist sulforaphane stimulates the PlGF transcript level nearly 30-fold in cultured human erythroblastoid cells.	sulforaphane	47-59	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
31408727-4	2019	Mimicking the effect of heme, the NRF2 agonist sulforaphane stimulates the PlGF transcript level nearly 30-fold in cultured human erythroblastoid cells.	sulforaphane	47-59	placental growth factor	Homo sapiens	75-79
31408727-5	2019	Heme and sulforaphane also induce transcripts for NRF2 itself, its partners MAFF and MAFG, and its competitor BACH1.	sulforaphane	9-21	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
31422078-0	2019	Sulforaphane protects from myocardial ischemia-reperfusion damage through the balanced activation of Nrf2/AhR.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
31408727-5	2019	Heme and sulforaphane also induce transcripts for NRF2 itself, its partners MAFF and MAFG, and its competitor BACH1.	sulforaphane	9-21	MAF bZIP transcription factor F	Homo sapiens	76-80
31422078-0	2019	Sulforaphane protects from myocardial ischemia-reperfusion damage through the balanced activation of Nrf2/AhR.	sulforaphane	0-12	aryl hydrocarbon receptor	Homo sapiens	106-109
31408727-5	2019	Heme and sulforaphane also induce transcripts for NRF2 itself, its partners MAFF and MAFG, and its competitor BACH1.	sulforaphane	9-21	MAF bZIP transcription factor G	Homo sapiens	85-89
31422078-2	2019	In this study we compared the effectiveness between sulforaphane (SFN), a well known activator of Nrf2 and the mechanical maneuver of post-conditioning (PostC) to confer cardioprotection in an in vivo cardiac ischemia-reperfusion model.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
31422078-2	2019	In this study we compared the effectiveness between sulforaphane (SFN), a well known activator of Nrf2 and the mechanical maneuver of post-conditioning (PostC) to confer cardioprotection in an in vivo cardiac ischemia-reperfusion model.	sulforaphane	66-69	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
31422078-5	2019	Bot, strategies preserved cardiac function, decreased infarct size, oxidative stress and inflammation, through common protective pathways; however, the aryl hydrocarbon receptor (AhR) also participated in the protection conferred by SFN.	sulforaphane	233-236	aryl hydrocarbon receptor	Homo sapiens	152-177
31422078-5	2019	Bot, strategies preserved cardiac function, decreased infarct size, oxidative stress and inflammation, through common protective pathways; however, the aryl hydrocarbon receptor (AhR) also participated in the protection conferred by SFN.	sulforaphane	233-236	aryl hydrocarbon receptor	Homo sapiens	179-182
31408727-5	2019	Heme and sulforaphane also induce transcripts for NRF2 itself, its partners MAFF and MAFG, and its competitor BACH1.	sulforaphane	9-21	BTB domain and CNC homolog 1	Homo sapiens	110-115
31422078-6	2019	Our data suggest that SFN-mediated cardioprotection involves transient Nrf2 activation, followed by phase I enzymes upregulation at the end of reperfusion, as a long-term protection mechanism.	sulforaphane	22-25	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
31454652-0	2019	High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells.	sulforaphane	28-40	epidermal growth factor receptor	Homo sapiens	15-19
31404596-5	2019	Docking studies revealed that Sulforaphane, Kaempferol and Apigenin exhibits the highest docking scores against SIRT1 & 5, 3 and 6 respectively.	sulforaphane	30-42	sirtuin 1	Homo sapiens	112-117
31037726-2	2019	Here we show, for the first time, the mechanism of c-Myb-mediated proliferation, invasion, and drug resistance in ovarian cancer (OC), the most lethal gynecological cancer, and a comparative analyses of dietary agents, curcumin, epigallocatechin-3-gallate (EGCG), and sulforaphane in inhibiting c-Myb activity.	sulforaphane	268-280	MYB proto-oncogene, transcription factor	Homo sapiens	51-56
31037726-9	2019	Higher c-Myb levels in patients with ovarian cancer lead to poor survival and our results indicate a possible effect of dietary factors EGCG and sulforaphane against c-Myb-mediated ovarian cancer progression and chemoresistance.	sulforaphane	145-157	MYB proto-oncogene, transcription factor	Homo sapiens	166-171
31454652-1	2019	BACKGROUND: Sulforaphane (SFN) has been shown to induce the production of reactive oxygen species (ROS) and inhibit epidermal growth factor receptor (EGFR)-mediated signaling in non-small-cell lung cancer (NSCLC).	sulforaphane	12-24	epidermal growth factor receptor	Homo sapiens	116-148
31454652-1	2019	BACKGROUND: Sulforaphane (SFN) has been shown to induce the production of reactive oxygen species (ROS) and inhibit epidermal growth factor receptor (EGFR)-mediated signaling in non-small-cell lung cancer (NSCLC).	sulforaphane	12-24	epidermal growth factor receptor	Homo sapiens	150-154
31454652-1	2019	BACKGROUND: Sulforaphane (SFN) has been shown to induce the production of reactive oxygen species (ROS) and inhibit epidermal growth factor receptor (EGFR)-mediated signaling in non-small-cell lung cancer (NSCLC).	sulforaphane	26-29	epidermal growth factor receptor	Homo sapiens	116-148
31454652-1	2019	BACKGROUND: Sulforaphane (SFN) has been shown to induce the production of reactive oxygen species (ROS) and inhibit epidermal growth factor receptor (EGFR)-mediated signaling in non-small-cell lung cancer (NSCLC).	sulforaphane	26-29	epidermal growth factor receptor	Homo sapiens	150-154
31454652-2	2019	NSCLC cells harboring constitutively active EGFR mutations are more sensitive to SFN treatment than cells with wild-type EGFR, but whether NSCLC cells with high levels of EGFR expression are more resistant or sensitive to SFN treatment is not known.	sulforaphane	81-84	epidermal growth factor receptor	Homo sapiens	44-48
31454652-9	2019	However, SFN induced apoptosis only in the high-EGFR-expressing CL1-0 subline.	sulforaphane	9-12	epidermal growth factor receptor	Homo sapiens	48-52
31454652-9	2019	However, SFN induced apoptosis only in the high-EGFR-expressing CL1-0 subline.	sulforaphane	9-12	adhesion G protein-coupled receptor L1	Homo sapiens	64-67
31454652-10	2019	Pretreatment with the antioxidant N-acetyl-L-cysteine prevented SFN-induced apoptosis in CL1-0 cells and production of gammaH2AX in both CL1-0 and CL1-5 cells.	sulforaphane	64-67	adhesion G protein-coupled receptor L1	Homo sapiens	89-92
31454652-10	2019	Pretreatment with the antioxidant N-acetyl-L-cysteine prevented SFN-induced apoptosis in CL1-0 cells and production of gammaH2AX in both CL1-0 and CL1-5 cells.	sulforaphane	64-67	adhesion G protein-coupled receptor L3	Homo sapiens	147-152
31454652-11	2019	shRNA-mediated knockdown of EGFR in CL1-5 cells rendered the cells susceptible to SFN-induced apoptosis.	sulforaphane	82-85	epidermal growth factor receptor	Homo sapiens	28-32
31454652-11	2019	shRNA-mediated knockdown of EGFR in CL1-5 cells rendered the cells susceptible to SFN-induced apoptosis.	sulforaphane	82-85	adhesion G protein-coupled receptor L1	Homo sapiens	36-39
31454652-13	2019	Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect cells from SFN-induced apoptosis.	sulforaphane	56-59	epidermal growth factor receptor	Homo sapiens	28-32
31454652-13	2019	Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect cells from SFN-induced apoptosis.	sulforaphane	95-98	epidermal growth factor receptor	Homo sapiens	28-32
31454652-13	2019	Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect cells from SFN-induced apoptosis.	sulforaphane	95-98	epidermal growth factor receptor	Homo sapiens	139-143
31454652-13	2019	Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect cells from SFN-induced apoptosis.	sulforaphane	95-98	epidermal growth factor receptor	Homo sapiens	28-32
31454652-13	2019	Cells with higher levels of EGFR were more resistant to SFN treatment and showed resistance to SFN-induced apoptosis, suggesting that high EGFR levels protect cells from SFN-induced apoptosis.	sulforaphane	95-98	epidermal growth factor receptor	Homo sapiens	139-143
31295528-0	2019	Sulforaphane protects against ethanol-induced apoptosis in neural crest cells through restoring epithelial-mesenchymal transition by epigenetically modulating the expression of Snail1.	sulforaphane	0-12	snail family transcriptional repressor 1	Homo sapiens	177-183
31671779-0	2019	The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.	sulforaphane	25-37	lysine acetyltransferase 5	Homo sapiens	84-89
31671779-0	2019	The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.	sulforaphane	25-37	androgen receptor	Homo sapiens	104-121
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	sulforaphane	0-12	androgen receptor	Homo sapiens	45-47
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	sulforaphane	0-12	kallikrein related peptidase 3	Homo sapiens	49-74
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	sulforaphane	0-12	BCL2 like 1	Homo sapiens	79-85
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	sulforaphane	0-12	lysine acetyltransferase 5	Homo sapiens	141-146
31671779-7	2019	The protective role of sulforaphane and capsaicin on prostate cancer may rely on mechanisms involving the inhibition of Tip60, AR and HIF-1alpha effects.	sulforaphane	23-35	lysine acetyltransferase 5	Homo sapiens	120-125
31671779-7	2019	The protective role of sulforaphane and capsaicin on prostate cancer may rely on mechanisms involving the inhibition of Tip60, AR and HIF-1alpha effects.	sulforaphane	23-35	androgen receptor	Homo sapiens	127-129
31671779-7	2019	The protective role of sulforaphane and capsaicin on prostate cancer may rely on mechanisms involving the inhibition of Tip60, AR and HIF-1alpha effects.	sulforaphane	23-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
31653857-6	2019	Consequently, Bardoxolone methyl and Sulforaphane, two known NRF2 agonists, impair virus production, suggesting that NRF2 activation restricts viral infection.	sulforaphane	37-49	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
31653857-6	2019	Consequently, Bardoxolone methyl and Sulforaphane, two known NRF2 agonists, impair virus production, suggesting that NRF2 activation restricts viral infection.	sulforaphane	37-49	NFE2 like bZIP transcription factor 2	Homo sapiens	117-121
31737167-0	2019	Sulforaphane: Its "Coming of Age" as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease.	sulforaphane	0-12	renin binding protein	Homo sapiens	29-33
31591291-12	2019	Moreover, SFN treatment attenuated obesity-induced autophagy, as detected by LC3 and Beclin1.	sulforaphane	10-13	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	77-80
31591291-12	2019	Moreover, SFN treatment attenuated obesity-induced autophagy, as detected by LC3 and Beclin1.	sulforaphane	10-13	beclin 1, autophagy related	Mus musculus	85-92
31295528-6	2019	Treatment with SFN also dramatically diminished ethanol-induced changes in the expression of E-cadherin and vimentin, and restored EMT in ethanol-exposed NCCs.	sulforaphane	15-18	cadherin 1	Homo sapiens	93-103
31295528-6	2019	Treatment with SFN also dramatically diminished ethanol-induced changes in the expression of E-cadherin and vimentin, and restored EMT in ethanol-exposed NCCs.	sulforaphane	15-18	vimentin	Homo sapiens	108-116
31295528-8	2019	SFN treatment diminished the ethanol-induced reduction of H3K4me3 at the promoter regions of the Snail1 gene, restored the expression of Snail1 and down-regulated Snail1 target gene E-cadherin.	sulforaphane	0-3	snail family transcriptional repressor 1	Homo sapiens	97-103
31295528-8	2019	SFN treatment diminished the ethanol-induced reduction of H3K4me3 at the promoter regions of the Snail1 gene, restored the expression of Snail1 and down-regulated Snail1 target gene E-cadherin.	sulforaphane	0-3	snail family transcriptional repressor 1	Homo sapiens	137-143
31295528-8	2019	SFN treatment diminished the ethanol-induced reduction of H3K4me3 at the promoter regions of the Snail1 gene, restored the expression of Snail1 and down-regulated Snail1 target gene E-cadherin.	sulforaphane	0-3	snail family transcriptional repressor 1	Homo sapiens	137-143
31295528-8	2019	SFN treatment diminished the ethanol-induced reduction of H3K4me3 at the promoter regions of the Snail1 gene, restored the expression of Snail1 and down-regulated Snail1 target gene E-cadherin.	sulforaphane	0-3	cadherin 1	Homo sapiens	182-192
31295528-9	2019	Knockdown of Snail1 significantly reduced the protective effects of SFN on ethanol-induced apoptosis.	sulforaphane	68-71	snail family transcriptional repressor 1	Homo sapiens	13-19
30941620-3	2019	SFN activates the antioxidant and anti-inflammatory responses by inducing Nrf2 pathway and inhibiting NF-kappaB.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
30930073-5	2019	The overview sums up the approaches implicated by the study that can potentially counteract the detrimental impact of hyperglycemia on vascular function in people with diabetes, including the clinical use of SGLT2 inhibitors for those with type 2 diabetes already being treated, for example, with metformin, along with dietary supplementation with broccoli-derived sulforaphane and tetrahydrobiopterin.	sulforaphane	365-377	solute carrier family 5 member 2	Homo sapiens	208-213
30941620-3	2019	SFN activates the antioxidant and anti-inflammatory responses by inducing Nrf2 pathway and inhibiting NF-kappaB.	sulforaphane	0-3	nuclear factor kappa B subunit 1	Homo sapiens	102-111
31302408-9	2019	Pharmacological activation of Nrf2 with sulforaphane (SFN) improved NO- and endothelium-derived hyperpolarizing factor-mediated endothelium-dependent vasodilation and H2O2-induced relaxation in vascular beds from aging rats.	sulforaphane	40-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
31486328-7	2019	Pre-treatment with sulforaphane, an activator of Nrf2, increased CBR1 expression, decreased liver enzymes such as aspartate aminotransferase and alanine transaminase, and reduced I/R-related pathological changes.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
31486328-7	2019	Pre-treatment with sulforaphane, an activator of Nrf2, increased CBR1 expression, decreased liver enzymes such as aspartate aminotransferase and alanine transaminase, and reduced I/R-related pathological changes.	sulforaphane	19-31	carbonyl reductase 1	Homo sapiens	65-69
33448841-0	2019	Sulforaphane-Conjugated Carbon Dots: A Versatile Nanosystem for Targeted Imaging and Inhibition of EGFR-Overexpressing Cancer Cells.	sulforaphane	0-12	epidermal growth factor receptor	Homo sapiens	99-103
33448841-2	2019	Therefore, we have built a multifunctional nanosystem based on sulforaphane-conjugated carbon dots (SFN-CDs) with thiourea skeleton and applied for EGFR-overexpressing cancer cells targeted imaging and inhibiting.	sulforaphane	63-75	RNA exonuclease 2	Homo sapiens	100-103
33448841-2	2019	Therefore, we have built a multifunctional nanosystem based on sulforaphane-conjugated carbon dots (SFN-CDs) with thiourea skeleton and applied for EGFR-overexpressing cancer cells targeted imaging and inhibiting.	sulforaphane	63-75	epidermal growth factor receptor	Homo sapiens	148-152
33448841-3	2019	The SFN-CDs are formed by grafting sulforaphane on the amino-rich yellow fluorescent carbon dots, which have excellent optical stability and can be distinguished from normal cells for targeted imaging of cancer cells.	sulforaphane	35-47	RNA exonuclease 2	Homo sapiens	4-7
31270951-1	2019	Sulforaphane (SFN) can effectively induce nuclear factor E2-related factor 2 (Nrf2), and zinc (Zn) can effectively induce metallothionein (MT), both of which have been shown to protect against diabetic cardiomyopathy (DCM).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
31270951-1	2019	Sulforaphane (SFN) can effectively induce nuclear factor E2-related factor 2 (Nrf2), and zinc (Zn) can effectively induce metallothionein (MT), both of which have been shown to protect against diabetic cardiomyopathy (DCM).	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
31270951-6	2019	In addition, combined SFN and Zn treatment increased Nrf2 function and MT expression in the heart of OVE mice to a greater extent than SFN or Zn alone.	sulforaphane	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
31270951-7	2019	This indicates that the dual activation of Nrf2 and MT by combined treatment with SFN and Zn may be more effective than monotherapy at preventing the development of DCM via complementary, additive mechanisms.	sulforaphane	82-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
31452747-0	2019	Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
31452747-1	2019	The present study aimed to investigate the mechanism underlying sulforaphane-mediated epigenetic regulation of nuclear factor-erythroid derived 2-like 2 (Nrf2) expression in human colon cancer.	sulforaphane	64-76	NFE2 like bZIP transcription factor 2	Homo sapiens	111-152
31452747-1	2019	The present study aimed to investigate the mechanism underlying sulforaphane-mediated epigenetic regulation of nuclear factor-erythroid derived 2-like 2 (Nrf2) expression in human colon cancer.	sulforaphane	64-76	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
31452747-7	2019	DNMT1 protein expression was inhibited by sulforaphane and 5-Aza co-treatment with TSA.	sulforaphane	42-54	DNA methyltransferase 1	Homo sapiens	0-5
31452747-8	2019	Nrf2 promoter methylation decreased significantly in the sulforaphane group compared with the control group.	sulforaphane	57-69	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31452747-10	2019	Nrf2 mRNA levels exhibited significant differences between the sulforaphane-treated and control groups, as well as between the 5-Aza+TSA and control groups, and the sulforaphane-treated and 5-Aza+TSA groups.	sulforaphane	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31452747-10	2019	Nrf2 mRNA levels exhibited significant differences between the sulforaphane-treated and control groups, as well as between the 5-Aza+TSA and control groups, and the sulforaphane-treated and 5-Aza+TSA groups.	sulforaphane	165-177	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31452747-11	2019	Nrf2 protein expression was also inhibited by sulforaphane, as well as 5-Aza co-treatment with TSA.	sulforaphane	46-58	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31452747-12	2019	The results revealed that sulforaphane may promote demethylation of the Nrf2 promoter region to increase activation of Nrf2, which induces chemoprevention of colon cancer.	sulforaphane	26-38	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
31452747-12	2019	The results revealed that sulforaphane may promote demethylation of the Nrf2 promoter region to increase activation of Nrf2, which induces chemoprevention of colon cancer.	sulforaphane	26-38	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
31473507-0	2019	Sulforaphane inhibits epithelial-mesenchymal transition by activating extracellular signal-regulated kinase 5 in lung cancer cells.	sulforaphane	0-12	mitogen-activated protein kinase 7	Homo sapiens	70-109
31473507-10	2019	Additionally, significantly increased expression of epithelial markers (E-cadherin and ZO-1), decreased expression of mesenchymal markers (N-cadherin and Snail1) and activation of ERK5 were observed after SFN treatment.	sulforaphane	205-208	cadherin 1	Homo sapiens	72-82
31473507-10	2019	Additionally, significantly increased expression of epithelial markers (E-cadherin and ZO-1), decreased expression of mesenchymal markers (N-cadherin and Snail1) and activation of ERK5 were observed after SFN treatment.	sulforaphane	205-208	tight junction protein 1	Homo sapiens	87-91
31473507-10	2019	Additionally, significantly increased expression of epithelial markers (E-cadherin and ZO-1), decreased expression of mesenchymal markers (N-cadherin and Snail1) and activation of ERK5 were observed after SFN treatment.	sulforaphane	205-208	cadherin 2	Homo sapiens	139-149
31473507-10	2019	Additionally, significantly increased expression of epithelial markers (E-cadherin and ZO-1), decreased expression of mesenchymal markers (N-cadherin and Snail1) and activation of ERK5 were observed after SFN treatment.	sulforaphane	205-208	snail family transcriptional repressor 1	Homo sapiens	154-160
31473507-10	2019	Additionally, significantly increased expression of epithelial markers (E-cadherin and ZO-1), decreased expression of mesenchymal markers (N-cadherin and Snail1) and activation of ERK5 were observed after SFN treatment.	sulforaphane	205-208	mitogen-activated protein kinase 7	Homo sapiens	180-184
31325205-0	2019	Targeting PLIN2/PLIN5-PPARgamma: Sulforaphane Disturbs the Maturation of Lipid Droplets.	sulforaphane	33-45	perilipin 2	Homo sapiens	10-15
31325205-0	2019	Targeting PLIN2/PLIN5-PPARgamma: Sulforaphane Disturbs the Maturation of Lipid Droplets.	sulforaphane	33-45	perilipin 5	Homo sapiens	16-21
31325205-0	2019	Targeting PLIN2/PLIN5-PPARgamma: Sulforaphane Disturbs the Maturation of Lipid Droplets.	sulforaphane	33-45	peroxisome proliferator activated receptor gamma	Homo sapiens	22-31
31325205-6	2019	Furthermore, over-expression of peroxisome proliferator-activated receptor gamma (PPARgamma) induces the accumulation of TAG and the up-regulation of PLIN2 and PLIN5, which are not reversed by SFN.	sulforaphane	193-196	peroxisome proliferator activated receptor gamma	Homo sapiens	32-80
31325205-6	2019	Furthermore, over-expression of peroxisome proliferator-activated receptor gamma (PPARgamma) induces the accumulation of TAG and the up-regulation of PLIN2 and PLIN5, which are not reversed by SFN.	sulforaphane	193-196	peroxisome proliferator activated receptor gamma	Homo sapiens	82-91
31394414-0	2019	Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.	sulforaphane	24-27	DNA methyltransferase 1	Homo sapiens	85-108
31394414-0	2019	Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.	sulforaphane	24-27	DNA methyltransferase 1	Homo sapiens	110-115
31394414-0	2019	Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.	sulforaphane	24-27	WNT inhibitory factor 1	Homo sapiens	117-140
31394414-0	2019	Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.	sulforaphane	24-27	WNT inhibitory factor 1	Homo sapiens	142-146
31569690-0	2019	Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells.	sulforaphane	0-12	Kruppel like factor 9	Homo sapiens	21-25
31569690-0	2019	Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells.	sulforaphane	0-12	peroxiredoxin 6	Homo sapiens	26-31
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	0-12	peroxiredoxin 6	Homo sapiens	169-184
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	0-12	peroxiredoxin 6	Homo sapiens	186-191
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	14-17	peroxiredoxin 6	Homo sapiens	169-184
31569690-1	2019	Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis.	sulforaphane	14-17	peroxiredoxin 6	Homo sapiens	186-191
31422075-6	2019	Bach1 silencing significantly enhanced sulforaphane-induced expression of HO-1 but had no effect on that of GCLC, GCLM, and NQO1 in young HBE cells.	sulforaphane	39-51	BTB domain and CNC homolog 1	Homo sapiens	0-5
31422075-6	2019	Bach1 silencing significantly enhanced sulforaphane-induced expression of HO-1 but had no effect on that of GCLC, GCLM, and NQO1 in young HBE cells.	sulforaphane	39-51	heme oxygenase 1	Homo sapiens	74-78
31422075-7	2019	In contrast, Bach1 silencing enhanced sulforaphane-induced expression of GCLC, GCLM and HO-1 but had no effect on that of NQO-1 in older HBE cells.	sulforaphane	38-50	BTB domain and CNC homolog 1	Homo sapiens	13-18
31422075-7	2019	In contrast, Bach1 silencing enhanced sulforaphane-induced expression of GCLC, GCLM and HO-1 but had no effect on that of NQO-1 in older HBE cells.	sulforaphane	38-50	glutamate-cysteine ligase catalytic subunit	Homo sapiens	73-77
31422075-7	2019	In contrast, Bach1 silencing enhanced sulforaphane-induced expression of GCLC, GCLM and HO-1 but had no effect on that of NQO-1 in older HBE cells.	sulforaphane	38-50	glutamate-cysteine ligase modifier subunit	Homo sapiens	79-83
31422075-7	2019	In contrast, Bach1 silencing enhanced sulforaphane-induced expression of GCLC, GCLM and HO-1 but had no effect on that of NQO-1 in older HBE cells.	sulforaphane	38-50	heme oxygenase 1	Homo sapiens	88-92
31480567-6	2019	Interestingly, there is also a gradual increase in the occurrence of terms related to diseases or to natural compounds, the most prominent being sulforaphane, curcumin, and resveratrol that modulate the Nrf2 pathway.	sulforaphane	145-157	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
31404577-7	2019	Here, we investigated the benefits of a mild and safe Nrf2 agonist, sulforaphane (SFN), in ameliorating SCD pathology in a murine model.	sulforaphane	68-80	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
31404577-9	2019	We found that dietary SFN administration for 14 days or 2 months increased the expression of Nrf2-dependent cytoprotective genes, but SFN uptake did not have deleterious effects on the food consumption and growth of SCD model mice.	sulforaphane	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
31404577-12	2019	These results indicate that dietary supplementation with SFN relieves SCD symptoms by inducing Nrf2 and support our contention that SFN is a potential drug for the long-term treatment of children with SCD.	sulforaphane	57-60	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
31302408-9	2019	Pharmacological activation of Nrf2 with sulforaphane (SFN) improved NO- and endothelium-derived hyperpolarizing factor-mediated endothelium-dependent vasodilation and H2O2-induced relaxation in vascular beds from aging rats.	sulforaphane	54-57	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
31302408-10	2019	SFN-induced effects were associated with increased Nrf2 (RMA, RCA) and reduced superoxide detection in RCA.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	51-55
31302408-13	2019	PDE5 inhibitor-induced relaxations of HPRA and HCC from ED patients were enhanced by SFN.	sulforaphane	85-88	phosphodiesterase 5A	Homo sapiens	0-4
30609032-0	2019	Effects of the isothiocyanate sulforaphane on TGF-beta1-induced rat cardiac fibroblast activation and extracellular matrix interactions.	sulforaphane	30-42	transforming growth factor, beta 1	Rattus norvegicus	46-55
30609032-10	2019	These studies demonstrate that sulforaphane attenuates TGF-beta1-induced myofibroblast formation and contractile activity.	sulforaphane	31-43	transforming growth factor, beta 1	Rattus norvegicus	55-64
31173751-0	2019	Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation.	sulforaphane	143-155	NFE2 like bZIP transcription factor 2	Rattus norvegicus	164-168
31173751-0	2019	Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation.	sulforaphane	143-155	heme oxygenase 1	Rattus norvegicus	169-173
31173751-3	2019	Sulforaphane has antioxidant properties via Nrf2 activation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	44-48
31173751-4	2019	The interaction of diabetes and/or sulforaphane with contrast media on Nrf2 regulation is not yet understood.	sulforaphane	35-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
31173751-9	2019	Immunofluorescence detection revealed increased Nrf2 expression in kidney sections after sulforaphane pretreatment.	sulforaphane	89-101	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-52
31173751-10	2019	Moreover, gene expression of Nrf2 and HO-1 were up-regulated, while IL-6 and caspase3 were down-regulated in kidney tissues of animals pretreated with sulforaphane.	sulforaphane	151-163	NFE2 like bZIP transcription factor 2	Rattus norvegicus	29-33
31173751-10	2019	Moreover, gene expression of Nrf2 and HO-1 were up-regulated, while IL-6 and caspase3 were down-regulated in kidney tissues of animals pretreated with sulforaphane.	sulforaphane	151-163	heme oxygenase 1	Rattus norvegicus	38-42
31173751-10	2019	Moreover, gene expression of Nrf2 and HO-1 were up-regulated, while IL-6 and caspase3 were down-regulated in kidney tissues of animals pretreated with sulforaphane.	sulforaphane	151-163	interleukin 6	Rattus norvegicus	68-72
31173751-10	2019	Moreover, gene expression of Nrf2 and HO-1 were up-regulated, while IL-6 and caspase3 were down-regulated in kidney tissues of animals pretreated with sulforaphane.	sulforaphane	151-163	caspase 3	Rattus norvegicus	77-85
31173751-12	2019	However, silencing Nrf2 using small interfering RNA (siRNA) abolished the cytoprotective effects of sulforaphane.	sulforaphane	100-112	NFE2 like bZIP transcription factor 2	Rattus norvegicus	19-23
31173751-13	2019	Collectively, the results of this study suggest that Nrf2/HO-1 pathway has a protective role against CIN and support the clinical implication of Nrf2 activators, such as sulforaphane, in CIN particularly in diabetic patients.	sulforaphane	170-182	NFE2 like bZIP transcription factor 2	Homo sapiens	53-57
31173751-13	2019	Collectively, the results of this study suggest that Nrf2/HO-1 pathway has a protective role against CIN and support the clinical implication of Nrf2 activators, such as sulforaphane, in CIN particularly in diabetic patients.	sulforaphane	170-182	heme oxygenase 1	Homo sapiens	58-62
31173751-13	2019	Collectively, the results of this study suggest that Nrf2/HO-1 pathway has a protective role against CIN and support the clinical implication of Nrf2 activators, such as sulforaphane, in CIN particularly in diabetic patients.	sulforaphane	170-182	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
31419224-6	2019	Nrf2 was able to decrease zymosan-induced PMN oxidative burst; sulforaphane-induced Nrf2 hyperexpression confirmed its implication.	sulforaphane	63-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
31419224-6	2019	Nrf2 was able to decrease zymosan-induced PMN oxidative burst; sulforaphane-induced Nrf2 hyperexpression confirmed its implication.	sulforaphane	63-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
31467925-3	2019	In short, we treated HK2 cells with HG and sulforaphane (SFN) as an Nrf2 activator.	sulforaphane	43-55	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
31467925-3	2019	In short, we treated HK2 cells with HG and sulforaphane (SFN) as an Nrf2 activator.	sulforaphane	57-60	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
31467925-6	2019	Treatment of HK2 cells with SFN caused HG-induced attenuation in EMT markers with activated Nrf2-HO-1.	sulforaphane	28-31	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
31467925-6	2019	Treatment of HK2 cells with SFN caused HG-induced attenuation in EMT markers with activated Nrf2-HO-1.	sulforaphane	28-31	heme oxygenase 1	Homo sapiens	97-101
30609032-11	2019	Sulforaphane also reduces expression of collagen-binding integrins and inhibits canonical and noncanonical TGF-beta signaling pathways.	sulforaphane	0-12	transforming growth factor alpha	Rattus norvegicus	107-115
31241937-0	2019	Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1alpha-Mediated Glycolysis in Hypoxia.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
31257541-0	2019	Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO-1 axis.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
31257541-0	2019	Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO-1 axis.	sulforaphane	0-12	heme oxygenase 1	Mus musculus	98-102
31257541-5	2019	Western blot assays revealed that the expression levels of nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), which exhibit oxidation resistance, were increased by sulforaphane treatment in DNCB-induced AD mice.	sulforaphane	184-196	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-93
31257541-5	2019	Western blot assays revealed that the expression levels of nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), which exhibit oxidation resistance, were increased by sulforaphane treatment in DNCB-induced AD mice.	sulforaphane	184-196	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
31257541-5	2019	Western blot assays revealed that the expression levels of nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), which exhibit oxidation resistance, were increased by sulforaphane treatment in DNCB-induced AD mice.	sulforaphane	184-196	heme oxygenase 1	Mus musculus	105-121
31257541-5	2019	Western blot assays revealed that the expression levels of nuclear factor-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1), which exhibit oxidation resistance, were increased by sulforaphane treatment in DNCB-induced AD mice.	sulforaphane	184-196	heme oxygenase 1	Mus musculus	123-127
31257541-6	2019	The present study suggested that sulforaphane exerted a therapeutic effect in the AD mouse model through the activation of the Nrf2/HO-1 axis as well as the suppression of Janus kinase 1/STAT3 signaling pathway.	sulforaphane	33-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
31257541-6	2019	The present study suggested that sulforaphane exerted a therapeutic effect in the AD mouse model through the activation of the Nrf2/HO-1 axis as well as the suppression of Janus kinase 1/STAT3 signaling pathway.	sulforaphane	33-45	heme oxygenase 1	Mus musculus	132-136
31257541-6	2019	The present study suggested that sulforaphane exerted a therapeutic effect in the AD mouse model through the activation of the Nrf2/HO-1 axis as well as the suppression of Janus kinase 1/STAT3 signaling pathway.	sulforaphane	33-45	Janus kinase 1	Mus musculus	172-186
31257541-6	2019	The present study suggested that sulforaphane exerted a therapeutic effect in the AD mouse model through the activation of the Nrf2/HO-1 axis as well as the suppression of Janus kinase 1/STAT3 signaling pathway.	sulforaphane	33-45	signal transducer and activator of transcription 3	Mus musculus	187-192
31241937-7	2019	Moreover, we revealed that sulforaphane decreased glycolytic metabolism in a hypoxia microenvironment by downregulating hypoxia-induced HIF-1alpha and blocking HIF-1alpha trans-localization to the nucleus in NMIBC cell lines.	sulforaphane	27-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	136-146
31396016-8	2019	CD34+ cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay.	sulforaphane	106-118	CD34 molecule	Homo sapiens	0-4
31396016-8	2019	CD34+ cells after six days in culture were stimulated with atorvastatin (AT), acetylsalicylic acid (ASA), sulforaphane (SR), resveratrol (RV), or metformin (Met) for 48 h. Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay.	sulforaphane	120-122	CD34 molecule	Homo sapiens	0-4
31396016-10	2019	On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2.	sulforaphane	77-89	heme oxygenase 1	Homo sapiens	45-61
31396016-10	2019	On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2.	sulforaphane	77-89	heme oxygenase 1	Homo sapiens	114-119
31396016-10	2019	On the other hand, the only one that induced heme oxygenase-1 expression was sulforaphane, a known activator of a HMOX1 inducer-NRF2.	sulforaphane	77-89	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
31100413-3	2019	Therefore, we assessed the effect of pharmacological activation of Nrf2, a redox-sensitive transcription factor, using sulforaphane in a mouse model of mixed granulocyte airway inflammation.	sulforaphane	119-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
31100413-5	2019	Our results show that sulforaphane administration reduced neutrophilic airway inflammation, myeloperoxidase (MPO) activity, and Th17 immune responses in a mixed granulocyte mouse model of asthma through Nrf2 activation.	sulforaphane	22-34	myeloperoxidase	Mus musculus	92-107
31100413-5	2019	Our results show that sulforaphane administration reduced neutrophilic airway inflammation, myeloperoxidase (MPO) activity, and Th17 immune responses in a mixed granulocyte mouse model of asthma through Nrf2 activation.	sulforaphane	22-34	myeloperoxidase	Mus musculus	109-112
31100413-5	2019	Our results show that sulforaphane administration reduced neutrophilic airway inflammation, myeloperoxidase (MPO) activity, and Th17 immune responses in a mixed granulocyte mouse model of asthma through Nrf2 activation.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	203-207
31100413-8	2019	Sulforaphane treatment led to induction of antioxidant enzymes (SOD, GPx) in AECs and pulmonary non-enzymatic antioxidants.	sulforaphane	0-12	peroxiredoxin 6 pseudogene 2	Mus musculus	69-72
31100413-10	2019	Collectively, our study presents the evidence that activation of Nrf2 by sulforaphane reduces neutrophilic airway inflammation by upregulation of antioxidants and downregulation of inflammatory cytokines in airways.	sulforaphane	73-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
31035011-13	2019	The gene expression results indicate that POR, TNFRSF1A and TNFSF10 genes expression are significantly upregulated by Cd-sulforaphane co-treatment than Cd or sulforaphane treatment alone.	sulforaphane	121-133	TNF superfamily member 10	Homo sapiens	60-67
31333462-7	2019	Nrf2 activation with sulforaphane protected against Hb toxicity in mice and cultured tubular epithelial cells, ameliorating renal function and kidney injury and reducing cell stress and death.	sulforaphane	21-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
31304933-2	2019	Schizophrenia patients are abnormal in oxidative stress, immune regulation, and anti-histone deacetylase (HDAC), while sulforaphane plays a role in anti-oxidative stress, anti-inflammation, and anti-HDAC.	sulforaphane	119-131	histone deacetylase 9	Homo sapiens	199-203
31035011-0	2019	Sulforaphane alleviates cadmium-induced toxicity in human mesenchymal stem cells through POR and TNFSF10 genes expression.	sulforaphane	0-12	cytochrome p450 oxidoreductase	Homo sapiens	89-92
31035011-0	2019	Sulforaphane alleviates cadmium-induced toxicity in human mesenchymal stem cells through POR and TNFSF10 genes expression.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	97-104
31035011-13	2019	The gene expression results indicate that POR, TNFRSF1A and TNFSF10 genes expression are significantly upregulated by Cd-sulforaphane co-treatment than Cd or sulforaphane treatment alone.	sulforaphane	121-133	cytochrome p450 oxidoreductase	Homo sapiens	42-45
31035011-13	2019	The gene expression results indicate that POR, TNFRSF1A and TNFSF10 genes expression are significantly upregulated by Cd-sulforaphane co-treatment than Cd or sulforaphane treatment alone.	sulforaphane	121-133	TNF receptor superfamily member 1A	Homo sapiens	47-55
31220272-7	2019	Effective prevention of PPK-like lesions in Krt16-null paw skin (via topical delivery of the Nrf2 inducer sulforaphane) involves the stimulation of Krt9 expression.	sulforaphane	106-118	keratin 16	Mus musculus	44-49
31220272-7	2019	Effective prevention of PPK-like lesions in Krt16-null paw skin (via topical delivery of the Nrf2 inducer sulforaphane) involves the stimulation of Krt9 expression.	sulforaphane	106-118	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
31220272-7	2019	Effective prevention of PPK-like lesions in Krt16-null paw skin (via topical delivery of the Nrf2 inducer sulforaphane) involves the stimulation of Krt9 expression.	sulforaphane	106-118	keratin 9	Mus musculus	148-152
31316719-1	2019	Aims: To investigate the effect of Nrf2 activator sulforaphane (SFN) on bladder compliance and the underlying mechanisms in a rat model of partial bladder outlet obstruction (BOO).	sulforaphane	50-62	NFE2 like bZIP transcription factor 2	Rattus norvegicus	35-39
30910589-1	2019	NF-kappaB contributes to the aggressiveness of pancreatic ductal adenocarcinoma (PDA), which is counteracted by the bioactive agent sulforaphane.	sulforaphane	132-144	nuclear factor kappa B subunit 1	Homo sapiens	0-9
30910589-3	2019	Using established cell lines, microRNA and gene arrays, we predicted miR-365a as the top candidate for the sulforaphane-induced inhibition of the NF-kappaB subunit c-Rel.	sulforaphane	107-119	microRNA 365a	Homo sapiens	69-77
30910589-3	2019	Using established cell lines, microRNA and gene arrays, we predicted miR-365a as the top candidate for the sulforaphane-induced inhibition of the NF-kappaB subunit c-Rel.	sulforaphane	107-119	nuclear factor kappa B subunit 1	Homo sapiens	146-155
30910589-3	2019	Using established cell lines, microRNA and gene arrays, we predicted miR-365a as the top candidate for the sulforaphane-induced inhibition of the NF-kappaB subunit c-Rel.	sulforaphane	107-119	REL proto-oncogene, NF-kB subunit	Homo sapiens	164-169
30910589-7	2019	Our observations suggest that sulforaphane-induced miR-365a-3p expression inhibits NF-kappaB activity by downregulating c-Rel, which prevents the progression of PDA.	sulforaphane	30-42	nuclear factor kappa B subunit 1	Homo sapiens	83-92
30910589-7	2019	Our observations suggest that sulforaphane-induced miR-365a-3p expression inhibits NF-kappaB activity by downregulating c-Rel, which prevents the progression of PDA.	sulforaphane	30-42	REL proto-oncogene, NF-kB subunit	Homo sapiens	120-125
31316719-1	2019	Aims: To investigate the effect of Nrf2 activator sulforaphane (SFN) on bladder compliance and the underlying mechanisms in a rat model of partial bladder outlet obstruction (BOO).	sulforaphane	64-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	35-39
31316719-8	2019	The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment.	sulforaphane	168-171	matrix metallopeptidase 1	Rattus norvegicus	18-23
31316719-8	2019	The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment.	sulforaphane	168-171	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	80-86
31316719-10	2019	Conclusions: Sulforaphane suppressed collagen deposition by regulating the MMP-1 and TIMP-1 expression and decreasing the collagen I/III expression ratio in BOO rats and improved bladder compliance.	sulforaphane	13-25	matrix metallopeptidase 1	Rattus norvegicus	75-80
31316719-10	2019	Conclusions: Sulforaphane suppressed collagen deposition by regulating the MMP-1 and TIMP-1 expression and decreasing the collagen I/III expression ratio in BOO rats and improved bladder compliance.	sulforaphane	13-25	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	85-91
31137828-0	2019	Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis.	sulforaphane	0-12	insulin	Homo sapiens	30-37
30965051-0	2019	HO-1 mediates the anti-inflammatory actions of Sulforaphane in monocytes stimulated with a mycoplasmal lipopeptide.	sulforaphane	47-59	heme oxygenase 1	Mus musculus	0-4
30965051-5	2019	Here, we report that Sulforaphane is an inducer of heme oxygenase (HO)-1, a cytoprotective enzyme that catalyzes the degradation of heme through signaling pathways in human monocytes.	sulforaphane	21-33	heme oxygenase 1	Homo sapiens	51-72
30965051-6	2019	Sulforaphane stimulated NF-E2-related factor 2 (Nrf2) translocation from the cytosol to the nucleus, and small interfering RNA-mediated knock-down of Nrf2 significantly inhibited Sulforaphane-induced HO-1 expression.	sulforaphane	0-12	heme oxygenase 1	Mus musculus	200-204
30965051-6	2019	Sulforaphane stimulated NF-E2-related factor 2 (Nrf2) translocation from the cytosol to the nucleus, and small interfering RNA-mediated knock-down of Nrf2 significantly inhibited Sulforaphane-induced HO-1 expression.	sulforaphane	179-191	heme oxygenase 1	Mus musculus	200-204
30965051-7	2019	Additionally, PI3K/Akt and ROS were also involved in Sulforaphane-induced Nrf2 activation and HO-1 expression, as revealed by the pharmacological inhibitors LY294002 and NAC.	sulforaphane	53-65	heme oxygenase 1	Mus musculus	94-98
30965051-9	2019	Furthermore, SnPP, a selective inhibitor of HO-1, reversed the inhibitory actions of Sulforaphane, while a carbon monoxide-releasing molecule, CORM-2, caused a significant decrease in MALP-2-induced cytokine secretion.	sulforaphane	85-97	heme oxygenase 1	Mus musculus	44-48
30965051-10	2019	Collectively, these results suggest that Sulforaphane functions as a suppressor of the MALP-2-induced inflammatory response, not only by inhibiting the expression of cytokines and the induction of HO-1 but also by diminishing NF-kappaB activation in cultured monocytes and the lungs of mice.	sulforaphane	41-53	heme oxygenase 1	Mus musculus	197-201
31217757-0	2019	Sulforaphane Attenuates Endometriosis in Rat Models Through Inhibiting PI3K/Akt Signaling Pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	76-79
31217757-11	2019	Additionally, posttreatment of sulforaphane inhibited levels of IL-6, IL-10, TNF-alpha, IFN-gamma, and VEGF in peritoneal fluid and plasma.	sulforaphane	31-43	interleukin 6	Rattus norvegicus	64-68
31217757-11	2019	Additionally, posttreatment of sulforaphane inhibited levels of IL-6, IL-10, TNF-alpha, IFN-gamma, and VEGF in peritoneal fluid and plasma.	sulforaphane	31-43	interleukin 10	Rattus norvegicus	70-75
31217757-11	2019	Additionally, posttreatment of sulforaphane inhibited levels of IL-6, IL-10, TNF-alpha, IFN-gamma, and VEGF in peritoneal fluid and plasma.	sulforaphane	31-43	tumor necrosis factor	Rattus norvegicus	77-86
31217757-11	2019	Additionally, posttreatment of sulforaphane inhibited levels of IL-6, IL-10, TNF-alpha, IFN-gamma, and VEGF in peritoneal fluid and plasma.	sulforaphane	31-43	interferon gamma	Rattus norvegicus	88-97
31217757-11	2019	Additionally, posttreatment of sulforaphane inhibited levels of IL-6, IL-10, TNF-alpha, IFN-gamma, and VEGF in peritoneal fluid and plasma.	sulforaphane	31-43	vascular endothelial growth factor A	Rattus norvegicus	103-107
31217757-12	2019	Posttreatment of sulforaphane regulated the expressions of VEGF, bcl-2, Bax, and cleaved Caspase-3 in EM model.	sulforaphane	17-29	vascular endothelial growth factor A	Rattus norvegicus	59-63
31217757-12	2019	Posttreatment of sulforaphane regulated the expressions of VEGF, bcl-2, Bax, and cleaved Caspase-3 in EM model.	sulforaphane	17-29	BCL2, apoptosis regulator	Rattus norvegicus	65-70
31217757-12	2019	Posttreatment of sulforaphane regulated the expressions of VEGF, bcl-2, Bax, and cleaved Caspase-3 in EM model.	sulforaphane	17-29	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
31217757-12	2019	Posttreatment of sulforaphane regulated the expressions of VEGF, bcl-2, Bax, and cleaved Caspase-3 in EM model.	sulforaphane	17-29	caspase 3	Rattus norvegicus	89-98
31217757-13	2019	The underlying mechanism revealed that sulforaphane attenuated EM in the rat model by inhibition of PI3K/Akt signaling pathway.	sulforaphane	39-51	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
30940595-3	2019	Results showed that SFN inhibited cell viability and induced DNA strand breaks at high doses (>=20 muM).	sulforaphane	20-23	latexin	Homo sapiens	102-105
30940595-4	2019	It also activated the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and increased intracellular glutathione (GSH) levels at 24 h. Pre-treatment with a low dose SFN (<=5 muM) protected against hydrogen peroxide (H2O2)-induced cell damage.	sulforaphane	166-169	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
30940595-4	2019	It also activated the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and increased intracellular glutathione (GSH) levels at 24 h. Pre-treatment with a low dose SFN (<=5 muM) protected against hydrogen peroxide (H2O2)-induced cell damage.	sulforaphane	166-169	latexin	Homo sapiens	178-181
30940595-7	2019	Manipulation of levels of GSH and Nrf2 in HepG2 cells confirmed that both molecules mediate the protective effects of SFN against H2O2.	sulforaphane	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
31059012-0	2019	Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
31137828-0	2019	Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis.	sulforaphane	0-12	serine palmitoyltransferase long chain base subunit 3	Homo sapiens	61-90
31137828-1	2019	Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance.	sulforaphane	0-12	insulin	Homo sapiens	179-186
31137828-1	2019	Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance.	sulforaphane	14-17	insulin	Homo sapiens	179-186
31137828-5	2019	The results showed that SFA dose-dependently increased glucose uptake and intracellular glycogen content by regulating the insulin receptor substrate 1 (IRS-1)/protein kinase B (Akt) signaling pathway in insulin-resistant HepG2 cells.	sulforaphane	24-27	insulin receptor substrate 1	Homo sapiens	123-151
31137828-5	2019	The results showed that SFA dose-dependently increased glucose uptake and intracellular glycogen content by regulating the insulin receptor substrate 1 (IRS-1)/protein kinase B (Akt) signaling pathway in insulin-resistant HepG2 cells.	sulforaphane	24-27	insulin receptor substrate 1	Homo sapiens	153-158
31137828-5	2019	The results showed that SFA dose-dependently increased glucose uptake and intracellular glycogen content by regulating the insulin receptor substrate 1 (IRS-1)/protein kinase B (Akt) signaling pathway in insulin-resistant HepG2 cells.	sulforaphane	24-27	protein tyrosine kinase 2 beta	Homo sapiens	160-176
31137828-5	2019	The results showed that SFA dose-dependently increased glucose uptake and intracellular glycogen content by regulating the insulin receptor substrate 1 (IRS-1)/protein kinase B (Akt) signaling pathway in insulin-resistant HepG2 cells.	sulforaphane	24-27	AKT serine/threonine kinase 1	Homo sapiens	178-181
31137828-5	2019	The results showed that SFA dose-dependently increased glucose uptake and intracellular glycogen content by regulating the insulin receptor substrate 1 (IRS-1)/protein kinase B (Akt) signaling pathway in insulin-resistant HepG2 cells.	sulforaphane	24-27	insulin	Homo sapiens	123-130
30606939-0	2019	Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.	sulforaphane	22-34	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
30790585-0	2019	Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf/J mice.	sulforaphane	16-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
30790585-4	2019	Sulforaphane activates Nrf2 and thus is considered a potential approach to treat several neurological disorders including autism.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	sulforaphane	9-21	signal transducer and activator of transcription 3	Mus musculus	75-80
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	sulforaphane	9-21	RAR-related orphan receptor gamma	Mus musculus	82-86
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	sulforaphane	9-21	interleukin 17A	Mus musculus	88-95
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	sulforaphane	9-21	interleukin 23 receptor	Mus musculus	100-106
30790585-7	2019	Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).	sulforaphane	9-21	nitric oxide synthase 2, inducible	Mus musculus	198-202
30790585-8	2019	Furthermore, sulforaphane-treated BTBR and C57 mice had upregulated enzymatic antioxidant defenses in neutrophils/cerebellum (SOD, GPx and GR expression and activity).	sulforaphane	13-25	peroxiredoxin 6 pseudogene 2	Mus musculus	131-134
30790585-9	2019	We reason that activation of Nrf2 by sulforaphane corrected Th17 immune dysfunction and oxidant-antioxidant imbalance in periphery and brain in BTBR mice.	sulforaphane	37-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
30606939-0	2019	Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation.	sulforaphane	22-34	NLR family, pyrin domain containing 3	Rattus norvegicus	109-114
30606939-7	2019	In addition, retinal expression levels of NLRP3, cleaved caspase-1 p20, IL-1beta p17, and ASC were dramatically increased in STZ-induced DR, and this was abolished by SFN intervention.	sulforaphane	167-170	NLR family, pyrin domain containing 3	Rattus norvegicus	42-47
30606939-7	2019	In addition, retinal expression levels of NLRP3, cleaved caspase-1 p20, IL-1beta p17, and ASC were dramatically increased in STZ-induced DR, and this was abolished by SFN intervention.	sulforaphane	167-170	heat shock protein family B (small) member 6	Rattus norvegicus	67-70
30606939-7	2019	In addition, retinal expression levels of NLRP3, cleaved caspase-1 p20, IL-1beta p17, and ASC were dramatically increased in STZ-induced DR, and this was abolished by SFN intervention.	sulforaphane	167-170	interleukin 1 beta	Rattus norvegicus	72-80
30606939-7	2019	In addition, retinal expression levels of NLRP3, cleaved caspase-1 p20, IL-1beta p17, and ASC were dramatically increased in STZ-induced DR, and this was abolished by SFN intervention.	sulforaphane	167-170	PYD and CARD domain containing	Rattus norvegicus	90-93
30606939-9	2019	SFN also exerted antioxidant effects, activated the Nrf2 pathway, and inhibited the NLRP3 inflammasome in Muller cells.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	52-56
30606939-9	2019	SFN also exerted antioxidant effects, activated the Nrf2 pathway, and inhibited the NLRP3 inflammasome in Muller cells.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	84-89
30856464-0	2019	Sulforaphane triggers a functional elongation of microglial process via the Akt signal.	sulforaphane	0-12	thymoma viral proto-oncogene 1	Mus musculus	76-79
31084542-0	2019	Sulforaphane Decrease of SERTAD1 Expression Triggers G1/S Arrest in Breast Cancer Cells.	sulforaphane	0-12	SERTA domain containing 1	Homo sapiens	25-32
31084542-6	2019	In addition, SERTAD1 (SEI-1) caused the accumulation of SFN-treated G1/S-phase cells.	sulforaphane	56-59	SERTA domain containing 1	Homo sapiens	13-20
31084542-6	2019	In addition, SERTAD1 (SEI-1) caused the accumulation of SFN-treated G1/S-phase cells.	sulforaphane	56-59	SERTA domain containing 1	Homo sapiens	22-27
30856464-6	2019	Mechanistic studies revealed that the SFN treatment increased Akt phosphorylation levels in primary cultured microglia and Akt inhibition blocked the effect of SFN on microglial process elongation, suggesting that the regulation of microglial process by SFN is mediated by Akt activation.	sulforaphane	38-41	thymoma viral proto-oncogene 1	Mus musculus	62-65
31084542-7	2019	The downregulation of SEI-1, cyclin D2, and histone deacetylase 3 suggested that in addition to the identified effects of SFN against breast cancer prevention, it may also exert antitumor activities in established breast cancer cells.	sulforaphane	122-125	SERTA domain containing 1	Homo sapiens	22-27
30856464-7	2019	Functional studies showed that Akt inhibition reversed the effect of SFN on both pro- and anti-inflammatory responses in lipopolysaccharide (LPS)-stimulated microglia.	sulforaphane	69-72	thymoma viral proto-oncogene 1	Mus musculus	31-34
31084542-7	2019	The downregulation of SEI-1, cyclin D2, and histone deacetylase 3 suggested that in addition to the identified effects of SFN against breast cancer prevention, it may also exert antitumor activities in established breast cancer cells.	sulforaphane	122-125	cyclin D2	Homo sapiens	29-38
30851639-2	2019	Sulforaphane is a Nrf2 activator but is unstable at ambient temperature.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
31084542-7	2019	The downregulation of SEI-1, cyclin D2, and histone deacetylase 3 suggested that in addition to the identified effects of SFN against breast cancer prevention, it may also exert antitumor activities in established breast cancer cells.	sulforaphane	122-125	histone deacetylase 3	Homo sapiens	44-65
30529616-6	2019	Upon exposure to the particles, the ARE-luciferase activity significantly increased in 2 h, reached a peak at 24 h, and remained high level at 72 h. This was in contrast to the transient activation of the ARE-reporter gene triggered by the Nrf2 activators tert-butylhydroquinone and sulforaphane, while ARE-luciferase activity dropped to the basal level at 72 h from the peak at 24 h. These results demonstrate the robustness of using cell-based ARE-reporter assays to evaluate the oxidative potential of fly ash.	sulforaphane	283-295	cap-n-collar	Drosophila melanogaster	240-244
31027362-8	2019	The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/beta-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.	sulforaphane	24-36	SRY-box transcription factor 9	Homo sapiens	79-83
31027362-8	2019	The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/beta-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.	sulforaphane	24-36	androgen receptor	Homo sapiens	85-87
31027362-8	2019	The phytochemicals like sulforaphane and curcumin that can concurrently target SOX9, AR and Wnt/beta-catenin signaling pathways in PCa may thus be beneficial in the chemoprevention of PCa.	sulforaphane	24-36	catenin beta 1	Homo sapiens	96-108
31056142-6	2019	RESULTS: Sulforaphane reduced TNF-alpha mediated HUVEC secretion of endothelin-1, VCAM1, ICAM1 and E-selectin, and prevented increased endothelial permeability.	sulforaphane	9-21	tumor necrosis factor	Homo sapiens	30-39
30826055-0	2019	CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response.	sulforaphane	9-21	TNF superfamily member 11	Homo sapiens	45-50
30826055-0	2019	CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response.	sulforaphane	9-21	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
30826055-8	2019	Taken together, these results suggest that CDDO-Me, SFN and tBHQ attenuate RANKL-induced osteoclastogenesis via activation of NRF2-mediated antioxidant response.	sulforaphane	52-55	TNF superfamily member 11	Homo sapiens	75-80
30826055-8	2019	Taken together, these results suggest that CDDO-Me, SFN and tBHQ attenuate RANKL-induced osteoclastogenesis via activation of NRF2-mediated antioxidant response.	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
31149042-11	2019	SFN ameliorated the progerin-induced aging defects and mitochondrial dysfunction in NP cells and IDD in Lmna G609G/G609G mice.	sulforaphane	0-3	lamin A	Mus musculus	104-108
31044154-0	2019	Sulforaphane Induces miR135b-5p and Its Target Gene, RASAL2, thereby Inhibiting the Progression of Pancreatic Cancer.	sulforaphane	0-12	RAS protein activator like 2	Homo sapiens	53-59
31044154-4	2019	We selected the top nine differentially expressed microRNAs, and miR135b-5p was chosen as the most important candidate for the sulforaphane-induced upregulation of the tumor suppressor gene RASAL2.	sulforaphane	127-139	RAS protein activator like 2	Homo sapiens	190-196
30835071-0	2019	Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	80-83
30835071-0	2019	Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	84-88
30835071-3	2019	The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling.	sulforaphane	57-69	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
30835071-3	2019	The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling.	sulforaphane	57-69	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
30835071-3	2019	The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling.	sulforaphane	71-74	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
30835071-3	2019	The current study investigates the protective effects of sulforaphane (SFN) against arsenic-induced renal damage via PI3K/Akt-mediated Nrf2 pathway signaling.	sulforaphane	71-74	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
30835071-8	2019	Pretreatment with SFN significantly (P < 0.05) attenuated renal ROS, OHdG, lipid peroxidation, and DNA damage, and increased phase II antioxidants via PI3K/Akt-mediated Nrf2 activation in renal tissue.	sulforaphane	18-21	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
30835071-8	2019	Pretreatment with SFN significantly (P < 0.05) attenuated renal ROS, OHdG, lipid peroxidation, and DNA damage, and increased phase II antioxidants via PI3K/Akt-mediated Nrf2 activation in renal tissue.	sulforaphane	18-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	172-176
30835071-9	2019	These results show that dietary supplementation with SFN protects against Ar-induced nephrotoxicity via the PI3K/Akt-mediated Nrf2 signaling pathway in the rat kidney.	sulforaphane	53-56	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
30835071-9	2019	These results show that dietary supplementation with SFN protects against Ar-induced nephrotoxicity via the PI3K/Akt-mediated Nrf2 signaling pathway in the rat kidney.	sulforaphane	53-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	126-130
30735751-3	2019	Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products.	sulforaphane	70-82	NFE2 like bZIP transcription factor 2	Homo sapiens	179-183
30735751-3	2019	Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products.	sulforaphane	70-82	NFE2 like bZIP transcription factor 2	Homo sapiens	185-206
30735751-3	2019	Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products.	sulforaphane	309-321	NFE2 like bZIP transcription factor 2	Homo sapiens	179-183
30735751-3	2019	Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products.	sulforaphane	309-321	NFE2 like bZIP transcription factor 2	Homo sapiens	185-206
31056142-2	2019	We assessed whether the antioxidant and NRF2-activator sulforaphane could mitigate endothelial and trophoblast dysfunction in vitro.	sulforaphane	55-67	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
30769286-9	2019	The importance of these findings was evident in a tauopathy mouse model where the effects of sulforaphane (SFN), an NRF2 inducer, were examined on neuroinflammation in Cx3cr1+/+ and Cx3cr1-/- mice.	sulforaphane	93-105	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
31056142-6	2019	RESULTS: Sulforaphane reduced TNF-alpha mediated HUVEC secretion of endothelin-1, VCAM1, ICAM1 and E-selectin, and prevented increased endothelial permeability.	sulforaphane	9-21	endothelin 1	Homo sapiens	68-80
31056142-6	2019	RESULTS: Sulforaphane reduced TNF-alpha mediated HUVEC secretion of endothelin-1, VCAM1, ICAM1 and E-selectin, and prevented increased endothelial permeability.	sulforaphane	9-21	vascular cell adhesion molecule 1	Homo sapiens	82-87
31056142-6	2019	RESULTS: Sulforaphane reduced TNF-alpha mediated HUVEC secretion of endothelin-1, VCAM1, ICAM1 and E-selectin, and prevented increased endothelial permeability.	sulforaphane	9-21	intercellular adhesion molecule 1	Homo sapiens	89-94
30769286-9	2019	The importance of these findings was evident in a tauopathy mouse model where the effects of sulforaphane (SFN), an NRF2 inducer, were examined on neuroinflammation in Cx3cr1+/+ and Cx3cr1-/- mice.	sulforaphane	93-105	chemokine (C-X3-C motif) receptor 1	Mus musculus	168-174
30769286-9	2019	The importance of these findings was evident in a tauopathy mouse model where the effects of sulforaphane (SFN), an NRF2 inducer, were examined on neuroinflammation in Cx3cr1+/+ and Cx3cr1-/- mice.	sulforaphane	93-105	chemokine (C-X3-C motif) receptor 1	Mus musculus	182-188
31056142-6	2019	RESULTS: Sulforaphane reduced TNF-alpha mediated HUVEC secretion of endothelin-1, VCAM1, ICAM1 and E-selectin, and prevented increased endothelial permeability.	sulforaphane	9-21	selectin E	Homo sapiens	99-109
30769286-9	2019	The importance of these findings was evident in a tauopathy mouse model where the effects of sulforaphane (SFN), an NRF2 inducer, were examined on neuroinflammation in Cx3cr1+/+ and Cx3cr1-/- mice.	sulforaphane	107-110	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
31056142-7	2019	In placental explants, sulforaphane reduced the secretion of soluble Flt-1, soluble endoglin and activin A.	sulforaphane	23-35	fms related receptor tyrosine kinase 1	Homo sapiens	69-74
31056142-7	2019	In placental explants, sulforaphane reduced the secretion of soluble Flt-1, soluble endoglin and activin A.	sulforaphane	23-35	endoglin	Homo sapiens	84-92
31056142-8	2019	Sulforaphane induced activation and nuclear translocation of NRF2 in HUVECs, inducing heme oxygenase 1.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
31056142-8	2019	Sulforaphane induced activation and nuclear translocation of NRF2 in HUVECs, inducing heme oxygenase 1.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	86-102
31056142-9	2019	NRF2 silencing blocked some but not all of sulforaphane"s effects in HUVECs.	sulforaphane	43-55	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
30684530-10	2019	Interestingly, sulforaphane, an antioxidant commonly found in cruciferous vegetables, was able to reverse the estrogen-induced epigenetic changes and gene silencing of COMT.	sulforaphane	15-27	catechol-O-methyltransferase	Homo sapiens	168-172
31049133-0	2019	Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	197-201
31049133-7	2019	Simultaneously, sulforaphane-enriched broccoli sprouts inhibited the LPS-induced activation of the NF-kappaB signaling pathway and the secretions of inflammatory proteins (iNOS, COX-2, TNF-alpha, IL-6, IL-1beta, PGE2, etc.	sulforaphane	16-28	cytochrome c oxidase II, mitochondrial	Mus musculus	178-183
31049133-7	2019	Simultaneously, sulforaphane-enriched broccoli sprouts inhibited the LPS-induced activation of the NF-kappaB signaling pathway and the secretions of inflammatory proteins (iNOS, COX-2, TNF-alpha, IL-6, IL-1beta, PGE2, etc.	sulforaphane	16-28	tumor necrosis factor	Mus musculus	185-194
31049133-7	2019	Simultaneously, sulforaphane-enriched broccoli sprouts inhibited the LPS-induced activation of the NF-kappaB signaling pathway and the secretions of inflammatory proteins (iNOS, COX-2, TNF-alpha, IL-6, IL-1beta, PGE2, etc.	sulforaphane	16-28	interleukin 6	Mus musculus	196-200
31049133-7	2019	Simultaneously, sulforaphane-enriched broccoli sprouts inhibited the LPS-induced activation of the NF-kappaB signaling pathway and the secretions of inflammatory proteins (iNOS, COX-2, TNF-alpha, IL-6, IL-1beta, PGE2, etc.	sulforaphane	16-28	interleukin 1 beta	Mus musculus	202-210
31049133-11	2019	Interestingly, sulforaphane-enriched broccoli sprouts improved the scopolamine-induced memory impairment in mice through Nrf2 activation, inhibiting neuronal apoptosis particularly through inhibition of caspase-3 activation which could lead to the neuroprotection against neurodegenerative disorders.	sulforaphane	15-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
31049133-11	2019	Interestingly, sulforaphane-enriched broccoli sprouts improved the scopolamine-induced memory impairment in mice through Nrf2 activation, inhibiting neuronal apoptosis particularly through inhibition of caspase-3 activation which could lead to the neuroprotection against neurodegenerative disorders.	sulforaphane	15-27	caspase 3	Mus musculus	203-212
30908527-8	2019	In digital result, only CYP79F1, in the glucoraphanin pathway, was up-regulated in young buds but absent from the other organs, which was consistent with the highest level of sulforaphane content being in this organ compared to mature buds, buds one day before flowering, flowers and leaves.	sulforaphane	175-187	cytochrome p450 79f1	Arabidopsis thaliana	24-31
30908527-10	2019	The study revealed that up-regulated expression of CYP79F1 plays a fundamental and direct role in sulforaphane production in inflorescences.	sulforaphane	98-110	cytochrome p450 79f1	Arabidopsis thaliana	51-58
30908527-12	2019	Synergistic expression of MAM1, MAM3, St5b-2, FMO GS-OX1, MY, ESP and ESM1 was found in sulforaphane metabolism.	sulforaphane	88-100	methylthioalkylmalate synthase 1	Arabidopsis thaliana	26-30
30908527-12	2019	Synergistic expression of MAM1, MAM3, St5b-2, FMO GS-OX1, MY, ESP and ESM1 was found in sulforaphane metabolism.	sulforaphane	88-100	2-isopropylmalate synthase 2	Arabidopsis thaliana	32-36
30908527-12	2019	Synergistic expression of MAM1, MAM3, St5b-2, FMO GS-OX1, MY, ESP and ESM1 was found in sulforaphane metabolism.	sulforaphane	88-100	Flavin-binding monooxygenase family protein	Arabidopsis thaliana	46-49
30908527-12	2019	Synergistic expression of MAM1, MAM3, St5b-2, FMO GS-OX1, MY, ESP and ESM1 was found in sulforaphane metabolism.	sulforaphane	88-100	epithiospecifier protein	Arabidopsis thaliana	62-65
30908527-12	2019	Synergistic expression of MAM1, MAM3, St5b-2, FMO GS-OX1, MY, ESP and ESM1 was found in sulforaphane metabolism.	sulforaphane	88-100	GDSL-like lipase/acylhydrolase superfamily protein	Arabidopsis thaliana	70-74
30643017-3	2019	Here we identify cell cycle and apoptosis regulator 2 (CCAR2) as an early target for acetylation in colon cancer cells treated with sulforaphane.	sulforaphane	132-144	cell cycle and apoptosis regulator 2	Homo sapiens	17-53
30643017-3	2019	Here we identify cell cycle and apoptosis regulator 2 (CCAR2) as an early target for acetylation in colon cancer cells treated with sulforaphane.	sulforaphane	132-144	cell cycle and apoptosis regulator 2	Homo sapiens	55-60
30643017-7	2019	Studies with sulforaphane+JQ1 in combination implicated a BET/BRD9 acetyl switch and a shift in the pool of acetyl "reader" proteins in favor of BRD9-regulated target genes.	sulforaphane	13-25	bromodomain containing 9	Homo sapiens	145-149
30679159-3	2019	CSC population was isolated using FACS analysis with the combined stem cell surface markers, CD44+/CD24-/CD49f+ The effect of sulforaphane on a stem-related embryonic oncogene CRIPTO-1/TDGF1 (CR1) was evaluated via ELISA.	sulforaphane	126-138	teratocarcinoma-derived growth factor 1	Mus musculus	176-182
30679159-3	2019	CSC population was isolated using FACS analysis with the combined stem cell surface markers, CD44+/CD24-/CD49f+ The effect of sulforaphane on a stem-related embryonic oncogene CRIPTO-1/TDGF1 (CR1) was evaluated via ELISA.	sulforaphane	126-138	teratocarcinoma-derived growth factor 1	Mus musculus	185-190
30637439-8	2019	Incubation experiments in SH-SY5Y neuroblastoma cells revealed significantly up to 6-fold elevated nuclear Nrf2 levels after stimulation with 10 muM carnosol (rosemary), 10 muM sulforaphane (broccoli), or 20 muM cinnamaldehyde (cinnamon).	sulforaphane	177-189	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	teratocarcinoma-derived growth factor 1	Mus musculus	147-150
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	teratocarcinoma-derived growth factor 1	Mus musculus	152-158
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	integrin alpha M	Mus musculus	170-173
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	teratocarcinoma-derived growth factor 1	Mus musculus	190-193
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	Nanog homeobox	Mus musculus	236-241
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	243-269
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	271-278
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	wingless-type MMTV integration site family, member 3	Mus musculus	281-285
30679159-6	2019	Further analysis of gene expression in these TNBC tumor cells revealed that sulforaphane significantly decreases the expression of cancer-specific CR1, CRIPTO-3/TDGF1P3 (CR3, a homologue of CR1), and various stem cell markers including Nanog, aldehyde dehydrogenase 1A1 (ALDH1A1), Wnt3, and Notch4.	sulforaphane	76-88	notch 4	Mus musculus	291-297
30679159-7	2019	Our results suggest that sulforaphane may control the malignant proliferation of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression and/or by inhibiting Cripto/Alk4 protein complex formation.	sulforaphane	25-37	teratocarcinoma-derived growth factor 1	Mus musculus	98-104
30679159-7	2019	Our results suggest that sulforaphane may control the malignant proliferation of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression and/or by inhibiting Cripto/Alk4 protein complex formation.	sulforaphane	25-37	teratocarcinoma-derived growth factor 1	Mus musculus	180-186
30679159-7	2019	Our results suggest that sulforaphane may control the malignant proliferation of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression and/or by inhibiting Cripto/Alk4 protein complex formation.	sulforaphane	25-37	activin A receptor, type 1B	Mus musculus	187-191
30453074-2	2019	In this study, we aimed to test the synergistic effect of two plant active compounds (sulphoraphane (SFN) and silymarin (SILY)) and several endemic plant species from Turkey (such as Phlomis leucophracta, Rubia davisiana, Alkanna tinctoria), which are known to have anticarcinogenic effect on androgen-independent PC3 and DU145, and androgen-dependent VCaP prostate cancer cell lines, with paclitaxel on the expression of cell cycle signaling and apoptosis regulator genes.	sulforaphane	86-99	14-3-3 protein sigma	Meleagris gallopavo	101-104
30813369-0	2019	Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-kappaB Inhibition and Nrf2/HO-1 Activation.	sulforaphane	28-40	mitogen-activated protein kinase 8	Homo sapiens	88-91
30813369-0	2019	Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-kappaB Inhibition and Nrf2/HO-1 Activation.	sulforaphane	28-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-96
30813369-0	2019	Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-kappaB Inhibition and Nrf2/HO-1 Activation.	sulforaphane	28-40	nuclear factor kappa B subunit 1	Homo sapiens	97-106
30813369-0	2019	Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-kappaB Inhibition and Nrf2/HO-1 Activation.	sulforaphane	28-40	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
30813369-0	2019	Anti-Inflammatory Effect of Sulforaphane on LPS-Activated Microglia Potentially through JNK/AP-1/NF-kappaB Inhibition and Nrf2/HO-1 Activation.	sulforaphane	28-40	heme oxygenase 1	Homo sapiens	127-131
30813369-1	2019	Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is present in the species of the Brassicaceae, especially in broccoli sprouts.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	29-72
30813369-1	2019	Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is present in the species of the Brassicaceae, especially in broccoli sprouts.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
30813369-1	2019	Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is present in the species of the Brassicaceae, especially in broccoli sprouts.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	29-72
30813396-7	2019	On the other hand, the treatment with SFN alone seemed to exert a protective effect, increasing the level of p53, which can block the expansion of possible DNA damaged cells.	sulforaphane	38-41	tumor protein p53	Homo sapiens	109-112
30262569-6	2019	Downregulation of NRF2 by the inhibitor Luteolin, or lentiviral shRNA knockdown, enhanced the chemotherapeutic efficacy of cytarabine, while MDS cells treated by NRF2 agonist Sulforaphane showed increased resistance to cytarabine.	sulforaphane	175-187	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
30262569-6	2019	Downregulation of NRF2 by the inhibitor Luteolin, or lentiviral shRNA knockdown, enhanced the chemotherapeutic efficacy of cytarabine, while MDS cells treated by NRF2 agonist Sulforaphane showed increased resistance to cytarabine.	sulforaphane	175-187	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
30813369-1	2019	Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is present in the species of the Brassicaceae, especially in broccoli sprouts.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
30626555-0	2019	Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo.	sulforaphane	27-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
30009400-3	2019	Sulforaphane was efficiently encapsulated with beta-CD at just 3 mmol L-1 , and the sulforaphane formed was stable during 3 h at 22  C. On the other hand, 40 mmol L-1 alpha-CD retained a high glucoraphanin content in broccoli juice.	sulforaphane	0-12	L1 cell adhesion molecule	Homo sapiens	70-73
30717178-0	2019	Sulforaphane Protect Against Cadmium-Induced Oxidative Damage in mouse Leydigs Cells by Activating Nrf2/ARE Signaling Pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
30717178-14	2019	SFN upregulated the mRNA expression of Nrf2, GSH-Px, HO-1, NQO1, and gamma-GCS in Cd-treated cells, indicating the protective effect of SFN against Cd-induced oxidative stress or cell apoptosis by activating the Nrf2/ARE signaling pathway.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
30717178-14	2019	SFN upregulated the mRNA expression of Nrf2, GSH-Px, HO-1, NQO1, and gamma-GCS in Cd-treated cells, indicating the protective effect of SFN against Cd-induced oxidative stress or cell apoptosis by activating the Nrf2/ARE signaling pathway.	sulforaphane	0-3	NAD(P)H dehydrogenase, quinone 1	Mus musculus	59-63
30717178-14	2019	SFN upregulated the mRNA expression of Nrf2, GSH-Px, HO-1, NQO1, and gamma-GCS in Cd-treated cells, indicating the protective effect of SFN against Cd-induced oxidative stress or cell apoptosis by activating the Nrf2/ARE signaling pathway.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	212-216
29533123-2	2019	This study aims to test whether sulforaphane (Sfn), a natural activator of nuclear factor erythroid 2-related factor 2 (Nrf2), reduces the chronic ischemic injury and cognitive dysfunction after VCI.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
29533123-2	2019	This study aims to test whether sulforaphane (Sfn), a natural activator of nuclear factor erythroid 2-related factor 2 (Nrf2), reduces the chronic ischemic injury and cognitive dysfunction after VCI.	sulforaphane	46-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
29533123-6	2019	Sfn-mediated neuroprotection was associated with enhanced activation of Nrf2 and upregulation of heme oxygenase 1.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	72-76
29533123-6	2019	Sfn-mediated neuroprotection was associated with enhanced activation of Nrf2 and upregulation of heme oxygenase 1.	sulforaphane	0-3	heme oxygenase 1	Rattus norvegicus	97-113
29533123-7	2019	Sfn also reduced neuronal and endothelial death and maintained the integrity of BBB after oxygen-glucose deprivation in vitro in an Nrf2 dependent manner.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	132-136
30535470-0	2019	Expression of cyclin B1, D1 and K in non-small cell lung cancer H1299 cells following treatment with sulforaphane.	sulforaphane	101-113	cyclin B1	Mus musculus	14-23
30535470-0	2019	Expression of cyclin B1, D1 and K in non-small cell lung cancer H1299 cells following treatment with sulforaphane.	sulforaphane	101-113	deiodinase, iodothyronine, type I	Mus musculus	25-33
30535470-3	2019	The aim of the present study was to evaluate the effect of SFN on apoptosis, cell cycle and expression of selected cell cycle-associated proteins: Cyclin B1, cyclin D1 and cyclin K in the H1299 cell line.	sulforaphane	59-62	cyclin B1	Homo sapiens	147-156
30535470-9	2019	SFN-induced cell cycle arrest was associated with a decrease in cyclin B1 expression.	sulforaphane	0-3	cyclin B1	Homo sapiens	64-73
30529165-0	2019	Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
30529165-2	2019	Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets including Nrf2-ARE pathway in chemoprevention.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
30529165-2	2019	Sulforaphane (SFN) is a phytochemical antioxidant known to affect multiple cellular targets including Nrf2-ARE pathway in chemoprevention.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-106
30529165-6	2019	SFN upregulated a large cluster of basal lung genes that are involved in mitochondrial oxidative phosphorylation, energy metabolism, and cardiovascular protection only in Nrf2+/+ mice.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	171-175
30529165-8	2019	Transcript abundance of the mitochondrial machinery genes remained significantly higher after hyperoxia exposure in SFN-treated Nrf2+/+ mice than in SFN-treated Nrf2-/- mice.	sulforaphane	116-119	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
30529165-10	2019	Minor improvement of hyperoxia-caused lung histopathology and neutrophilia by SFN in Nrf2-/- mice implies Nrf2-independent or alternate effector mechanisms.	sulforaphane	78-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
30529165-10	2019	Minor improvement of hyperoxia-caused lung histopathology and neutrophilia by SFN in Nrf2-/- mice implies Nrf2-independent or alternate effector mechanisms.	sulforaphane	78-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
30529165-11	2019	In conclusion, SFN is suggested to be as a preventive intervention in a preclinical model of acute lung injury by linking mitochondria and Nrf2.	sulforaphane	15-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
30009400-3	2019	Sulforaphane was efficiently encapsulated with beta-CD at just 3 mmol L-1 , and the sulforaphane formed was stable during 3 h at 22  C. On the other hand, 40 mmol L-1 alpha-CD retained a high glucoraphanin content in broccoli juice.	sulforaphane	0-12	L1 cell adhesion molecule	Homo sapiens	163-166
31787726-0	2019	Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK and AKT Phosphorylation.	sulforaphane	0-12	mitogen-activated protein kinase 14	Homo sapiens	95-102
30689624-0	2019	Sulforaphane Attenuates H2O2-induced Oxidant Stress in Human Trabecular Meshwork Cells (HTMCs) via the Phosphatidylinositol 3-Kinase (PI3K)/Serine/Threonine Kinase (Akt)-Mediated Factor-E2-Related Factor 2 (Nrf2) Signaling Activation.	sulforaphane	0-12	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	103-132
30689624-0	2019	Sulforaphane Attenuates H2O2-induced Oxidant Stress in Human Trabecular Meshwork Cells (HTMCs) via the Phosphatidylinositol 3-Kinase (PI3K)/Serine/Threonine Kinase (Akt)-Mediated Factor-E2-Related Factor 2 (Nrf2) Signaling Activation.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	165-168
30689624-0	2019	Sulforaphane Attenuates H2O2-induced Oxidant Stress in Human Trabecular Meshwork Cells (HTMCs) via the Phosphatidylinositol 3-Kinase (PI3K)/Serine/Threonine Kinase (Akt)-Mediated Factor-E2-Related Factor 2 (Nrf2) Signaling Activation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
30689624-1	2019	BACKGROUND The aim of this study was to investigate whether and how sulforaphane (SFN), a novel promising nuclear factor-E2-related factor 2 (Nrf2) activator, exerted antioxidative stress through activating Nrf2 signaling.	sulforaphane	68-80	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
30689624-1	2019	BACKGROUND The aim of this study was to investigate whether and how sulforaphane (SFN), a novel promising nuclear factor-E2-related factor 2 (Nrf2) activator, exerted antioxidative stress through activating Nrf2 signaling.	sulforaphane	68-80	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
30689624-1	2019	BACKGROUND The aim of this study was to investigate whether and how sulforaphane (SFN), a novel promising nuclear factor-E2-related factor 2 (Nrf2) activator, exerted antioxidative stress through activating Nrf2 signaling.	sulforaphane	82-85	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
30689624-1	2019	BACKGROUND The aim of this study was to investigate whether and how sulforaphane (SFN), a novel promising nuclear factor-E2-related factor 2 (Nrf2) activator, exerted antioxidative stress through activating Nrf2 signaling.	sulforaphane	82-85	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
30689624-8	2019	CONCLUSIONS These results indicated a novel application for SFN in attenuating H2O2-induced oxidative stress in HTMCs through activating PI3K/Akt/Nrf2 signaling pathway.	sulforaphane	60-63	AKT serine/threonine kinase 1	Homo sapiens	142-145
30689624-8	2019	CONCLUSIONS These results indicated a novel application for SFN in attenuating H2O2-induced oxidative stress in HTMCs through activating PI3K/Akt/Nrf2 signaling pathway.	sulforaphane	60-63	NFE2 like bZIP transcription factor 2	Homo sapiens	146-150
30551472-5	2019	We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG.	sulforaphane	23-35	glyoxalase I	Homo sapiens	75-80
30551472-5	2019	We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG.	sulforaphane	23-35	glyoxalase I	Homo sapiens	92-97
30551472-5	2019	We found quercetin and sulforaphane increased cell viability, and enhanced Glo-1 functions (Glo-1 activity, the reduced glutathione and advanced glycation end-products levels) as well as Glo-1 protein and mRNA levels in SH-SY5Y cells cultured with HG.	sulforaphane	23-35	glyoxalase I	Homo sapiens	92-97
30578708-8	2019	Furthermore, SFN improves multiple mitochondrial bioactivities, such as mitochondrial membrane potential, ATP, and the electron transfer chain based on PGC-1alpha pathway.	sulforaphane	13-16	PPARG coactivator 1 alpha	Homo sapiens	152-162
30528536-4	2019	SFN is supposed to act primarily as an antioxidant due to the activation of the Nrf2-Keap1 signaling pathway.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
30528536-4	2019	SFN is supposed to act primarily as an antioxidant due to the activation of the Nrf2-Keap1 signaling pathway.	sulforaphane	0-3	kelch like ECH associated protein 1	Homo sapiens	85-90
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
30551472-6	2019	Meanwhile, quercetin and sulforaphane activated Nrf2/ARE pathway, reflected by the raised Nrf2 and p-Nrf2 levels, and the elevated protein and mRNA levels of gamma-glutamycysteine synthase (gamma-GCS), a known target gene of Nrf2/ARE signaling.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
31787726-0	2019	Sulforaphane Exhibits Cytotoxic Effects against Primary Effusion Lymphoma Cells by Suppressing p38MAPK and AKT Phosphorylation.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	107-110
31787726-7	2019	In addition, SFN inhibited the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and AKT in PEL cells.	sulforaphane	13-16	mitogen-activated protein kinase 14	Homo sapiens	50-86
31787726-7	2019	In addition, SFN inhibited the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and AKT in PEL cells.	sulforaphane	13-16	mitogen-activated protein kinase 14	Homo sapiens	88-95
31787726-7	2019	In addition, SFN inhibited the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) and AKT in PEL cells.	sulforaphane	13-16	AKT serine/threonine kinase 1	Homo sapiens	101-104
31787726-10	2019	Our data and previous literature indicate that SFN represses the phosphorylation of p38MAPK and AKT, which results in PEL cell apoptosis.	sulforaphane	47-50	mitogen-activated protein kinase 14	Homo sapiens	84-91
31787726-10	2019	Our data and previous literature indicate that SFN represses the phosphorylation of p38MAPK and AKT, which results in PEL cell apoptosis.	sulforaphane	47-50	AKT serine/threonine kinase 1	Homo sapiens	96-99
31001960-0	2019	Sulforaphane Potentially Ameliorates Arsenic Induced Hepatotoxicity in Albino Wistar Rats: Implication of PI3K/Akt/Nrf2 Signaling Pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	111-114
31001960-0	2019	Sulforaphane Potentially Ameliorates Arsenic Induced Hepatotoxicity in Albino Wistar Rats: Implication of PI3K/Akt/Nrf2 Signaling Pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
31001960-3	2019	The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway.	sulforaphane	69-81	AKT serine/threonine kinase 1	Rattus norvegicus	162-165
31001960-3	2019	The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway.	sulforaphane	69-81	NFE2 like bZIP transcription factor 2	Rattus norvegicus	170-174
31001960-3	2019	The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway.	sulforaphane	83-86	AKT serine/threonine kinase 1	Rattus norvegicus	162-165
31001960-3	2019	The current study was designed to evaluate the protective ability of sulforaphane (SFN) against arsenic (As) induced hepatotoxicity by activation of PI3K induced Akt and Nrf2 mediated signaling pathway.	sulforaphane	83-86	NFE2 like bZIP transcription factor 2	Rattus norvegicus	170-174
31001960-10	2019	However, pretreatment with SFN significantly (p<0.05) decreased the levels of ALAD, Arsenic concentration, and brought antioxidant enzymes into normal levels.	sulforaphane	27-30	aminolevulinate dehydratase	Rattus norvegicus	81-85
31266422-0	2019	Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing NLRP3 inflammasome activation in a rat model of retinal ischemia/reperfusion injury.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Rattus norvegicus	84-89
30662355-0	2019	Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling.	sulforaphane	0-12	angiotensinogen	Homo sapiens	24-38
30662355-0	2019	Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling.	sulforaphane	0-12	NADPH oxidase 4	Homo sapiens	104-108
30662355-0	2019	Sulforaphane Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Migration via Suppression of NOX4/ROS/Nrf2 Signaling.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117
30662355-3	2019	In the present study, we aimed to investigate the effects of SFN on Ang II-induced abnormal migration of HVSMCs as well as the underlying mechanisms of those effects.	sulforaphane	61-64	angiotensinogen	Homo sapiens	68-74
30662355-4	2019	The results showed that Ang II-induced HVSMC proliferation and migration were inhibited by treatment with SFN.	sulforaphane	106-109	angiotensinogen	Homo sapiens	24-30
30315662-0	2019	Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2.	sulforaphane	22-34	sulfatase 2	Mus musculus	77-88
30315662-4	2019	Therefore, the goal of this study was to determine the ability of sulforaphane to reduce skin cancer in mice through inhibition of sulfatase-2 enzyme.	sulforaphane	66-78	sulfatase 2	Mus musculus	131-142
30315662-9	2019	We found that, sulforaphane blocked sulfatase-2 activity, leading to significant elevation in HSPGs as well as significant reduction in glypican-3.	sulforaphane	15-27	sulfatase 2	Mus musculus	36-47
30315662-9	2019	We found that, sulforaphane blocked sulfatase-2 activity, leading to significant elevation in HSPGs as well as significant reduction in glypican-3.	sulforaphane	15-27	glypican 3	Mus musculus	136-146
30315662-10	2019	In addition, sulforaphane significantly activated Nrf2 and reduced both the gene and protein expression of NFkappaB, TNF-alpha, IL-1beta and caspase-3.	sulforaphane	13-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-54
30315662-10	2019	In addition, sulforaphane significantly activated Nrf2 and reduced both the gene and protein expression of NFkappaB, TNF-alpha, IL-1beta and caspase-3.	sulforaphane	13-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-115
30315662-10	2019	In addition, sulforaphane significantly activated Nrf2 and reduced both the gene and protein expression of NFkappaB, TNF-alpha, IL-1beta and caspase-3.	sulforaphane	13-25	tumor necrosis factor	Mus musculus	117-126
30315662-10	2019	In addition, sulforaphane significantly activated Nrf2 and reduced both the gene and protein expression of NFkappaB, TNF-alpha, IL-1beta and caspase-3.	sulforaphane	13-25	interleukin 1 beta	Mus musculus	128-136
30315662-10	2019	In addition, sulforaphane significantly activated Nrf2 and reduced both the gene and protein expression of NFkappaB, TNF-alpha, IL-1beta and caspase-3.	sulforaphane	13-25	caspase 3	Mus musculus	141-150
30315662-12	2019	The collective results indicate that sulforaphane suppresses skin cancer via blocking sulfatase-2 with subsequent elevation in HSPGs and reduction in glypican-3.	sulforaphane	37-49	sulfatase 2	Mus musculus	86-97
30315662-12	2019	The collective results indicate that sulforaphane suppresses skin cancer via blocking sulfatase-2 with subsequent elevation in HSPGs and reduction in glypican-3.	sulforaphane	37-49	glypican 3	Mus musculus	150-160
30312763-0	2018	Sulforaphane ameliorates steroid insensitivity through an Nrf2-dependent pathway in cigarette smoke-exposed asthmatic mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
30365975-10	2019	Knockdown of p53 attenuated the ability of SNF to inhibit anoikis resistance and sphere formation in A549 cancer cells, suggesting that the presence of p53 in NSCLC cancer cells is involved in the sensitivity to SFN.	sulforaphane	212-215	tumor protein p53	Homo sapiens	13-16
30365975-10	2019	Knockdown of p53 attenuated the ability of SNF to inhibit anoikis resistance and sphere formation in A549 cancer cells, suggesting that the presence of p53 in NSCLC cancer cells is involved in the sensitivity to SFN.	sulforaphane	212-215	tumor protein p53	Homo sapiens	152-155
30397784-0	2018	Correction to: Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
30346043-10	2019	Thapsigargin-induced ER stress and small interference RNA (siRNA)-mediated Nrf2 inhibition abrogated the protective effects of berberine in vitro, whereas siRNA-mediated suppression of ER stress and sulforaphane-induced Nrf2 activation further improved those effects.	sulforaphane	199-211	NFE2 like bZIP transcription factor 2	Homo sapiens	220-224
30096452-6	2018	The aim of this study was to evaluate the effect of different concentrations of sulforaphane extracted from broccoli sprout (SEBS) on viability, death pattern, and expression alterations of CDX1/2 as well as miRNA-9 and miRNA-326 in normal (HF2FF) and gastric cancer cell lines.	sulforaphane	80-92	caudal type homeobox 1	Homo sapiens	190-196
30305397-4	2018	We show that NEAT1 is a novel target gene of heat shock transcription factor 1 (HSF1) and is up-regulated when the heat shock response pathway is activated by sulforaphane (SFN) or elevated temperature.	sulforaphane	159-171	nuclear paraspeckle assembly transcript 1	Homo sapiens	13-18
30305397-4	2018	We show that NEAT1 is a novel target gene of heat shock transcription factor 1 (HSF1) and is up-regulated when the heat shock response pathway is activated by sulforaphane (SFN) or elevated temperature.	sulforaphane	159-171	heat shock transcription factor 1	Homo sapiens	45-78
30305397-4	2018	We show that NEAT1 is a novel target gene of heat shock transcription factor 1 (HSF1) and is up-regulated when the heat shock response pathway is activated by sulforaphane (SFN) or elevated temperature.	sulforaphane	159-171	heat shock transcription factor 1	Homo sapiens	80-84
30305397-4	2018	We show that NEAT1 is a novel target gene of heat shock transcription factor 1 (HSF1) and is up-regulated when the heat shock response pathway is activated by sulforaphane (SFN) or elevated temperature.	sulforaphane	173-176	nuclear paraspeckle assembly transcript 1	Homo sapiens	13-18
30305397-4	2018	We show that NEAT1 is a novel target gene of heat shock transcription factor 1 (HSF1) and is up-regulated when the heat shock response pathway is activated by sulforaphane (SFN) or elevated temperature.	sulforaphane	173-176	heat shock transcription factor 1	Homo sapiens	45-78
30305397-4	2018	We show that NEAT1 is a novel target gene of heat shock transcription factor 1 (HSF1) and is up-regulated when the heat shock response pathway is activated by sulforaphane (SFN) or elevated temperature.	sulforaphane	173-176	heat shock transcription factor 1	Homo sapiens	80-84
30305397-6	2018	In line with this, SFN induced the formation of NEAT1-containing paraspeckles via an HSF1-dependent mechanism.	sulforaphane	19-22	nuclear paraspeckle assembly transcript 1	Homo sapiens	48-53
30305397-6	2018	In line with this, SFN induced the formation of NEAT1-containing paraspeckles via an HSF1-dependent mechanism.	sulforaphane	19-22	heat shock transcription factor 1	Homo sapiens	85-89
30032437-0	2018	Sulforaphane protects granulosa cells against oxidative stress via activation of NRF2-ARE pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Bos taurus	81-85
30032437-1	2018	Sulforaphane (SFN) has been considered as an indirect antioxidant and potential inducer of the Nrf2-ARE pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Bos taurus	95-99
30032437-1	2018	Sulforaphane (SFN) has been considered as an indirect antioxidant and potential inducer of the Nrf2-ARE pathway.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Bos taurus	95-99
30032437-5	2018	Following H2O2 exposure, expression of NRF2 was found to be significantly increased (p < 0.05) in SFN-pretreated cells, while no significant differences were observed between group 3 and group 5, although the expression was significantly increased compared to the control group.	sulforaphane	101-104	NFE2 like bZIP transcription factor 2	Bos taurus	39-43
30032437-6	2018	Moreover, the relative abundance of the NRF2 downstream target antioxidant genes (CAT, PRDX1, SOD1 and TXN1) were higher (fold change ranged from 7 to 14, p < 0.05) in sulforaphane pretreated GCs.	sulforaphane	171-183	NFE2 like bZIP transcription factor 2	Bos taurus	40-44
30032437-6	2018	Moreover, the relative abundance of the NRF2 downstream target antioxidant genes (CAT, PRDX1, SOD1 and TXN1) were higher (fold change ranged from 7 to 14, p < 0.05) in sulforaphane pretreated GCs.	sulforaphane	171-183	peroxiredoxin 1	Bos taurus	87-92
30032437-6	2018	Moreover, the relative abundance of the NRF2 downstream target antioxidant genes (CAT, PRDX1, SOD1 and TXN1) were higher (fold change ranged from 7 to 14, p < 0.05) in sulforaphane pretreated GCs.	sulforaphane	171-183	superoxide dismutase [Cu-Zn]	Bos taurus	94-98
30032437-8	2018	Thus, we suggest that SFN pretreatment effectively protects GCs against oxidative damage through the activation of the NRF2-ARE pathway, whereas addition of SFN during oxidative insult failed to rescue GCs.	sulforaphane	22-25	NFE2 like bZIP transcription factor 2	Bos taurus	119-123
30312763-8	2018	These findings indicate that cigarette smoke induces steroid unresponsiveness in asthmatic airways, and that sulforaphane restores steroid sensitivity via upregulation of Nrf2 and enhancement of HDAC2 expression and activity.	sulforaphane	109-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	171-175
30312763-8	2018	These findings indicate that cigarette smoke induces steroid unresponsiveness in asthmatic airways, and that sulforaphane restores steroid sensitivity via upregulation of Nrf2 and enhancement of HDAC2 expression and activity.	sulforaphane	109-121	histone deacetylase 2	Mus musculus	195-200
30312763-3	2018	OVA-sensitized and challenged BALB/c mice were exposed to cigarette smoke and then treated with dexamethasone, sulforaphane (an activator of Nrf2), or their combination.	sulforaphane	111-123	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
30312763-5	2018	In OVA-sensitized and challenged mice exposed to cigarette smoke and treated with sulforaphane, Nrf2-mediated antioxidant responses were upregulated to a greater extent, and steroid sensitivity of asthmatic responses was restored.	sulforaphane	82-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
30312763-6	2018	Moreover, the expression and activity of histone deacetylase 2 (HDAC2), a key regulator of steroid responsiveness, was reduced in mice exposed to cigarette smoke, but restored by sulforaphane treatment.	sulforaphane	179-191	histone deacetylase 2	Mus musculus	41-62
30312763-6	2018	Moreover, the expression and activity of histone deacetylase 2 (HDAC2), a key regulator of steroid responsiveness, was reduced in mice exposed to cigarette smoke, but restored by sulforaphane treatment.	sulforaphane	179-191	histone deacetylase 2	Mus musculus	64-69
30251384-0	2018	Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells.	sulforaphane	7-19	AKT serine/threonine kinase 1	Homo sapiens	66-69
30251384-0	2018	Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/MAPK and activating the Nrf2/ARE signalling pathways in HepG2 cells.	sulforaphane	7-19	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
30251384-9	2018	CONCLUSIONS: Benzyl sulforaphane was superior to SFN in inhibiting Akt/MAPK and activating Nrf2/ARE signalling pathways in HepG2 cells, which indicated that BSFN could be a safe therapeutic strategy for the prevention and treatment of liver cancer.	sulforaphane	49-52	AKT serine/threonine kinase 1	Homo sapiens	67-70
30243843-9	2018	Our findings suggest that AREs drive the dynamic transcriptional events of Nrf2 target genes in the zebrafish larvae on exposure to sulforaphane.	sulforaphane	132-144	nfe2 like bZIP transcription factor 2a	Danio rerio	75-79
30350234-0	2018	Alleviating the progression of acute myeloid leukemia (AML) by sulforaphane through controlling miR-155 levels.	sulforaphane	63-75	microRNA 155	Homo sapiens	96-103
30350234-5	2018	The present study tried to evaluate pathologic effect of miR-155 in patients in various subgroups of AML, and then pioneered in assessing miR-155 levels by the effect of sulforaphane in different AML cell lines.	sulforaphane	170-182	microRNA 155	Homo sapiens	138-145
30302904-7	2018	SFN also increases butyric acid levels in the mouse colon, and repairs the injury to the mucosal epithelium of the colon and cecum through the upregulation of the expression of tight junction proteins and GLP2.	sulforaphane	0-3	glucagon-like peptide 2 receptor	Mus musculus	205-209
30350234-11	2018	More or less, about 80% reduction in miR-155 expression was almost observed after 48 h treatment with 60 microM sulforaphane in all four studied cell lines.	sulforaphane	112-124	microRNA 155	Homo sapiens	37-44
30350234-13	2018	The anti-cancer effects of sulforaphane can be correlated with reduction of miR-155 levels.	sulforaphane	27-39	microRNA 155	Homo sapiens	76-83
30350234-14	2018	These findings suggested that sulforaphane could induce more differentiation in myeloid progenitor cells through controlling the miR-155, thereby mitigating the progress of AML.	sulforaphane	30-42	microRNA 155	Homo sapiens	129-136
30542282-9	2018	Interestingly, treatment with SFN also potentiated the antiallodynic effects of morphine in sciatic nerve-injured mice by regularizing the down regulation of MOR in the spinal cord and/or hippocampus.	sulforaphane	30-33	opioid receptor, mu 1	Mus musculus	158-161
30595796-5	2018	We describe herein that the cruciferous vegetable-derived metabolite, sulforaphane (SFN), activates Nrf2 and delays senescence of human MRC-5 and BJ fibroblasts in vitro.	sulforaphane	70-82	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
30595796-5	2018	We describe herein that the cruciferous vegetable-derived metabolite, sulforaphane (SFN), activates Nrf2 and delays senescence of human MRC-5 and BJ fibroblasts in vitro.	sulforaphane	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
30464238-5	2018	Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5).	sulforaphane	21-33	matrix metallopeptidase 1	Homo sapiens	158-162
30464238-5	2018	Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5).	sulforaphane	21-33	matrix metallopeptidase 13	Homo sapiens	164-169
30464238-5	2018	Selected bioactives, sulforaphane, apigenin, isoliquiritigenin and luteolin, inhibited one or more interleukin-1-induced metalloproteinases implicated in OA (MMP1, MMP13, ADAMTS4, ADAMTS5).	sulforaphane	21-33	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	171-178
30464238-7	2018	Sulforaphane inhibited the IL-1/NFkappaB and Wnt3a/TCF/Lef pathways and increased TGFbeta/Smad2/3 and BMP6/Smad1/5/8 signalling.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	32-40
30464238-7	2018	Sulforaphane inhibited the IL-1/NFkappaB and Wnt3a/TCF/Lef pathways and increased TGFbeta/Smad2/3 and BMP6/Smad1/5/8 signalling.	sulforaphane	0-12	Wnt family member 3A	Homo sapiens	45-50
30464238-7	2018	Sulforaphane inhibited the IL-1/NFkappaB and Wnt3a/TCF/Lef pathways and increased TGFbeta/Smad2/3 and BMP6/Smad1/5/8 signalling.	sulforaphane	0-12	transforming growth factor beta 1	Homo sapiens	82-89
30464238-7	2018	Sulforaphane inhibited the IL-1/NFkappaB and Wnt3a/TCF/Lef pathways and increased TGFbeta/Smad2/3 and BMP6/Smad1/5/8 signalling.	sulforaphane	0-12	SMAD family member 2	Homo sapiens	90-97
30464238-7	2018	Sulforaphane inhibited the IL-1/NFkappaB and Wnt3a/TCF/Lef pathways and increased TGFbeta/Smad2/3 and BMP6/Smad1/5/8 signalling.	sulforaphane	0-12	bone morphogenetic protein 6	Homo sapiens	102-106
30464238-7	2018	Sulforaphane inhibited the IL-1/NFkappaB and Wnt3a/TCF/Lef pathways and increased TGFbeta/Smad2/3 and BMP6/Smad1/5/8 signalling.	sulforaphane	0-12	SMAD family member 1	Homo sapiens	107-114
30464238-10	2018	The combination of sulforaphane and isoliquiritigenin was synergistic for inhibiting MMP13 gene expression in chondrocytes.	sulforaphane	19-31	matrix metallopeptidase 13	Homo sapiens	85-90
30445774-9	2018	Those results suggest that a regular exposure to SR by broccoli consumption or SR supplements may enhance Glo1.	sulforaphane	49-51	glyoxalase I	Homo sapiens	106-110
30352240-0	2018	Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells.	sulforaphane	0-12	histone deacetylase 6	Homo sapiens	48-53
30352240-0	2018	Sulforaphane induces autophagy by inhibition of HDAC6-mediated PTEN activation in triple negative breast cancer cells.	sulforaphane	0-12	phosphatase and tensin homolog	Homo sapiens	63-67
30352240-11	2018	Further study demonstrated that sulforaphane induced autophagy by down-regulating expression of HDAC6, which resulted in increased membrane translocation and acetylation modification of phosphatase and tensin homolog (PTEN).	sulforaphane	32-44	histone deacetylase 6	Homo sapiens	96-101
30352240-11	2018	Further study demonstrated that sulforaphane induced autophagy by down-regulating expression of HDAC6, which resulted in increased membrane translocation and acetylation modification of phosphatase and tensin homolog (PTEN).	sulforaphane	32-44	phosphatase and tensin homolog	Homo sapiens	218-222
30581529-0	2018	Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells.	sulforaphane	0-12	aquaporin 8	Homo sapiens	23-27
30581529-6	2018	To this purpose, we evaluated whether sulforaphane could somehow affect aquaporin-8-mediated H2O2 transport and/or Nox-mediated H2O2 production in B1647 cell line.	sulforaphane	38-50	aquaporin 8	Homo sapiens	72-83
30581529-7	2018	Results indicated that sulforaphane inhibited both aquaporin-8 and Nox2 expression, thus decreasing B1647 cells viability.	sulforaphane	23-35	aquaporin 8	Homo sapiens	51-62
30581529-7	2018	Results indicated that sulforaphane inhibited both aquaporin-8 and Nox2 expression, thus decreasing B1647 cells viability.	sulforaphane	23-35	cytochrome b-245 beta chain	Homo sapiens	67-71
30581529-8	2018	Moreover, the data obtained by coimmunoprecipitation technique demonstrated that these two proteins are linked to each other; thus, sulforaphane has an important role in modulating the downstream events triggered by the axis Nox2-aquaporin-8.	sulforaphane	132-144	cytochrome b-245 beta chain	Homo sapiens	225-229
30581529-8	2018	Moreover, the data obtained by coimmunoprecipitation technique demonstrated that these two proteins are linked to each other; thus, sulforaphane has an important role in modulating the downstream events triggered by the axis Nox2-aquaporin-8.	sulforaphane	132-144	aquaporin 8	Homo sapiens	230-241
30581529-9	2018	Cell treatment with sulforaphane also reduced the expression of peroxiredoxin-1, which is increased in almost all acute myeloid leukemia subtypes.	sulforaphane	20-32	peroxiredoxin 1	Homo sapiens	64-79
30445774-0	2018	The Effect of Sulforaphane on Glyoxalase I Expression and Activity in Peripheral Blood Mononuclear Cells.	sulforaphane	14-26	glyoxalase I	Homo sapiens	30-42
30445774-2	2018	Recent studies suggest that SR increases expression/activity of glyoxalase 1 (Glo1), an enzyme involved in the degradation of methylglyoxal, is major precursor of advanced glycation end products.	sulforaphane	28-30	glyoxalase I	Homo sapiens	64-76
30445774-2	2018	Recent studies suggest that SR increases expression/activity of glyoxalase 1 (Glo1), an enzyme involved in the degradation of methylglyoxal, is major precursor of advanced glycation end products.	sulforaphane	28-30	glyoxalase I	Homo sapiens	78-82
30445774-9	2018	Those results suggest that a regular exposure to SR by broccoli consumption or SR supplements may enhance Glo1.	sulforaphane	79-81	glyoxalase I	Homo sapiens	106-110
30396938-8	2018	Expression of pCdk2, Akt, and Raptor were reduced following long-term SFN-exposure, but remained unchanged when SFN was applied for short periods of time.	sulforaphane	70-73	AKT serine/threonine kinase 1	Homo sapiens	21-24
30106111-0	2018	Sulforaphane protects rabbit corneas against oxidative stress injury in keratoconus through activation of the Nrf-2/HO-1 antioxidant pathway.	sulforaphane	0-12	heme oxygenase 1	Oryctolagus cuniculus	116-120
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	BCL2 apoptosis regulator	Homo sapiens	80-97
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	BCL2 apoptosis regulator	Homo sapiens	99-104
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	BCL2 apoptosis regulator	Homo sapiens	107-112
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	cytochrome c, somatic	Homo sapiens	135-147
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	caspase 3	Homo sapiens	149-158
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	175-178
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	tumor protein p53	Homo sapiens	218-221
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	interferon alpha inducible protein 27	Homo sapiens	223-226
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	cyclin D1	Homo sapiens	228-237
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	242-246
30226534-10	2018	Sulforaphane inhibited multiple cancer-associated signaling pathways, including B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, cytochrome c, Caspase-3, phosphorylated AKT, phosphorylated nuclear factor-kappaB, P53, P27, Cyclin-D1 and cMyc, and reduced the expression levels of human epidermal growth factor receptor 2 in human ovarian cancer cells.	sulforaphane	0-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	291-325
30015387-5	2018	Docking results suggest that benzyl isothiocyanate, phenethyl isothiocyanate, and DL-sulforaphane are more potent inhibitors of UCHL5 than USP14, and these ITCs could interact with the catalytic triads of UCHL5 and USP14.	sulforaphane	82-97	ubiquitin C-terminal hydrolase L5	Homo sapiens	128-133
30015387-5	2018	Docking results suggest that benzyl isothiocyanate, phenethyl isothiocyanate, and DL-sulforaphane are more potent inhibitors of UCHL5 than USP14, and these ITCs could interact with the catalytic triads of UCHL5 and USP14.	sulforaphane	82-97	ubiquitin specific peptidase 14	Homo sapiens	139-144
30015387-5	2018	Docking results suggest that benzyl isothiocyanate, phenethyl isothiocyanate, and DL-sulforaphane are more potent inhibitors of UCHL5 than USP14, and these ITCs could interact with the catalytic triads of UCHL5 and USP14.	sulforaphane	82-97	ubiquitin C-terminal hydrolase L5	Homo sapiens	205-210
30015387-5	2018	Docking results suggest that benzyl isothiocyanate, phenethyl isothiocyanate, and DL-sulforaphane are more potent inhibitors of UCHL5 than USP14, and these ITCs could interact with the catalytic triads of UCHL5 and USP14.	sulforaphane	82-97	ubiquitin specific peptidase 14	Homo sapiens	215-220
30106111-1	2018	The aim of the present study was to examine whether activation of the nuclear factor E2-related factor 2 (Nrf-2)/heme oxygenase-1 (HO-1) antioxidant pathway in the cornea was involved in the protective effect of sulforaphane (SF) following keratoconus (KC) injury.	sulforaphane	212-224	heme oxygenase 1	Oryctolagus cuniculus	113-129
30106111-1	2018	The aim of the present study was to examine whether activation of the nuclear factor E2-related factor 2 (Nrf-2)/heme oxygenase-1 (HO-1) antioxidant pathway in the cornea was involved in the protective effect of sulforaphane (SF) following keratoconus (KC) injury.	sulforaphane	212-224	heme oxygenase 1	Oryctolagus cuniculus	131-135
29953917-4	2018	PXDN expression in response to H2O2 and the Nrf2-specific inducers, tert-butylhydroquinone (tBHQ) and sulforaphane (SFN), was determined by western blotting and immunofluorescence microscopy, in HeLa and HEK293 cells.	sulforaphane	102-114	peroxidasin	Homo sapiens	0-4
30026053-0	2018	Relevance of the natural HDAC inhibitor sulforaphane as a chemopreventive agent in urologic tumors.	sulforaphane	40-52	histone deacetylase 9	Homo sapiens	25-29
29953917-6	2018	We observed elevated Nrf2 nuclear translocation and increased PXDN protein expression in response to H2O2, tBHQ and SFN, in both cell lines.	sulforaphane	116-119	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
30420908-2	2018	The isothiocyanate sulforaphane (SF) is widely understood to be the most effective natural activator of the Nrf2 pathway.	sulforaphane	33-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
29953917-4	2018	PXDN expression in response to H2O2 and the Nrf2-specific inducers, tert-butylhydroquinone (tBHQ) and sulforaphane (SFN), was determined by western blotting and immunofluorescence microscopy, in HeLa and HEK293 cells.	sulforaphane	116-119	peroxidasin	Homo sapiens	0-4
29953917-6	2018	We observed elevated Nrf2 nuclear translocation and increased PXDN protein expression in response to H2O2, tBHQ and SFN, in both cell lines.	sulforaphane	116-119	peroxidasin	Homo sapiens	62-66
30096613-0	2018	Nrf2 expression and function, but not MT expression, is indispensable for sulforaphane-mediated protection against intermittent hypoxia-induced cardiomyopathy in mice.	sulforaphane	74-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
30386243-9	2018	Pretreatment with sulforaphane, a naturally occurring Nrf2 activator, prevented depression-like phenotype in mice after inflammation, or chronic social defeat stress.	sulforaphane	18-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
30096613-3	2018	As an activator of Nrf2, sulforaphane (SFN) has attracted attention as a potential protective agent against cardiovascular disease.	sulforaphane	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
30096613-3	2018	As an activator of Nrf2, sulforaphane (SFN) has attracted attention as a potential protective agent against cardiovascular disease.	sulforaphane	39-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
30096613-4	2018	Here, we investigated whether SFN can up-regulate cardiac Nrf2 expression and function, as well as MT expression, to prevent IH-induced cardiomyopathy, and if so, whether Nrf2 and MT are indispensable for this preventive effect.	sulforaphane	30-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
30096613-7	2018	In IH-exposed WT mice, SFN induced significant increases in the expression levels of Nrf2 and its downstream antioxidant target genes, as well as those of MT, but these effects were not seen in IH-exposed Nrf2-KO mice.	sulforaphane	23-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
30096613-9	2018	These results suggest that SFN-induced MT expression is Nrf2-dependent, and SFN prevents IH-induced cardiomyopathy in a Nrf2-dependent manner, for which MT is dispensable.	sulforaphane	27-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
30096613-9	2018	These results suggest that SFN-induced MT expression is Nrf2-dependent, and SFN prevents IH-induced cardiomyopathy in a Nrf2-dependent manner, for which MT is dispensable.	sulforaphane	76-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
30091431-9	2018	In addition, the SFN-treated obese mice had a significantly increased insulin receptor substrate 1 (IRS-1) protein level (P < 0.05), markedly elevated Akt activation, as well as dramatically enhanced phosphorylation of PDK-1 (P < 0.05) when compared with the SFN-untreated obese mice.	sulforaphane	17-20	insulin receptor substrate 1	Mus musculus	70-98
30257470-5	2018	Finally, we discuss about the crosstalk between these three critical pathways as well as how the anti-inflammatory antioxidant phytochemicals like sulforaphane (SFN) and curcumin (CUR), which can also target AR, can be ideal candidates in the chemoprevention of PCa.	sulforaphane	147-159	androgen receptor	Homo sapiens	208-210
30257470-5	2018	Finally, we discuss about the crosstalk between these three critical pathways as well as how the anti-inflammatory antioxidant phytochemicals like sulforaphane (SFN) and curcumin (CUR), which can also target AR, can be ideal candidates in the chemoprevention of PCa.	sulforaphane	161-164	androgen receptor	Homo sapiens	208-210
30338040-0	2018	Sulforaphane inhibits growth and blocks Wnt/beta-catenin signaling of colorectal cancer cells.	sulforaphane	0-12	catenin beta 1	Homo sapiens	44-56
30338040-6	2018	Co-expression of the transcription factors LEF1 or TCF4 prevented formation of these structures and rescued inhibition of Wnt/beta-catenin signaling by SFN.	sulforaphane	152-155	lymphoid enhancer binding factor 1	Homo sapiens	43-47
30338040-6	2018	Co-expression of the transcription factors LEF1 or TCF4 prevented formation of these structures and rescued inhibition of Wnt/beta-catenin signaling by SFN.	sulforaphane	152-155	transcription factor 4	Homo sapiens	51-55
30338040-6	2018	Co-expression of the transcription factors LEF1 or TCF4 prevented formation of these structures and rescued inhibition of Wnt/beta-catenin signaling by SFN.	sulforaphane	152-155	catenin beta 1	Homo sapiens	126-138
30091431-9	2018	In addition, the SFN-treated obese mice had a significantly increased insulin receptor substrate 1 (IRS-1) protein level (P < 0.05), markedly elevated Akt activation, as well as dramatically enhanced phosphorylation of PDK-1 (P < 0.05) when compared with the SFN-untreated obese mice.	sulforaphane	17-20	insulin receptor substrate 1	Mus musculus	100-105
30091431-9	2018	In addition, the SFN-treated obese mice had a significantly increased insulin receptor substrate 1 (IRS-1) protein level (P < 0.05), markedly elevated Akt activation, as well as dramatically enhanced phosphorylation of PDK-1 (P < 0.05) when compared with the SFN-untreated obese mice.	sulforaphane	17-20	thymoma viral proto-oncogene 1	Mus musculus	154-157
30091431-9	2018	In addition, the SFN-treated obese mice had a significantly increased insulin receptor substrate 1 (IRS-1) protein level (P < 0.05), markedly elevated Akt activation, as well as dramatically enhanced phosphorylation of PDK-1 (P < 0.05) when compared with the SFN-untreated obese mice.	sulforaphane	17-20	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	222-227
30091431-10	2018	Moreover, the SFN-treated obese mice exhibited a significantly enhanced translocation of GLUT4 (P < 0.05) to the plasma membrane in the muscle compared to the obese mice without SFN treatment.	sulforaphane	14-17	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	89-94
30091431-11	2018	In conclusion, our results support the notion that SFN acts as a promising agent to improve glucose tolerance through the up-regulation of insulin signaling mainly involving the IRS-1/Akt/GLUT4 pathway in the muscle.	sulforaphane	51-54	insulin receptor substrate 1	Mus musculus	178-183
30091431-11	2018	In conclusion, our results support the notion that SFN acts as a promising agent to improve glucose tolerance through the up-regulation of insulin signaling mainly involving the IRS-1/Akt/GLUT4 pathway in the muscle.	sulforaphane	51-54	thymoma viral proto-oncogene 1	Mus musculus	184-187
30091431-11	2018	In conclusion, our results support the notion that SFN acts as a promising agent to improve glucose tolerance through the up-regulation of insulin signaling mainly involving the IRS-1/Akt/GLUT4 pathway in the muscle.	sulforaphane	51-54	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	188-193
30063917-0	2018	Sulforaphane improves leptin responsiveness in high-fat high-sucrose diet-fed obese mice.	sulforaphane	0-12	leptin	Mus musculus	22-28
29547002-9	2018	Agonists of the cytoprotective transcription factor Nrf2 (sulforaphane and compound 7) reverse defects in phagocytosis of S. pneumoniae and nontypeable Haemophilus influenzae by COPD AMs.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
29633255-0	2018	HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.	sulforaphane	74-86	histone deacetylase 5	Homo sapiens	0-5
29633255-0	2018	HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells.	sulforaphane	74-86	lysine demethylase 1A	Homo sapiens	6-10
29633255-5	2018	Through screening a panel of epigenetic modifying drugs, we showed that a natural bioactive HDAC inhibitor, sulforaphane, downregulated HDAC5 transcription by blocking USF1 activity.	sulforaphane	108-120	histone deacetylase 5	Homo sapiens	136-141
30063917-5	2018	To date, the role of sulforaphane (SFN, an isothiocyanate derived from cruciferous vegetables) on leptin responsiveness has not been examined, in spite of its known beneficial effects toward lowering body weight gain in DIO.	sulforaphane	21-33	leptin	Mus musculus	98-104
29633255-5	2018	Through screening a panel of epigenetic modifying drugs, we showed that a natural bioactive HDAC inhibitor, sulforaphane, downregulated HDAC5 transcription by blocking USF1 activity.	sulforaphane	108-120	upstream transcription factor 1	Homo sapiens	168-172
30063917-5	2018	To date, the role of sulforaphane (SFN, an isothiocyanate derived from cruciferous vegetables) on leptin responsiveness has not been examined, in spite of its known beneficial effects toward lowering body weight gain in DIO.	sulforaphane	35-38	leptin	Mus musculus	98-104
29633255-6	2018	Sulforaphane facilitated LSD1 ubiquitination and degradation in an HDAC5-dependent manner.	sulforaphane	0-12	lysine demethylase 1A	Homo sapiens	25-29
30063917-7	2018	SFN treatment (0.5 mg/kg/day, s.c.) for 23 days in HFHS-fed mice improved the responsiveness to intraperitoneally-injected leptin by promoting significant decreases in cumulative food intake and body weight gain.	sulforaphane	0-3	leptin	Mus musculus	123-129
29633255-6	2018	Sulforaphane facilitated LSD1 ubiquitination and degradation in an HDAC5-dependent manner.	sulforaphane	0-12	histone deacetylase 5	Homo sapiens	67-72
29633255-8	2018	shRNA knockdown and sulforaphane inhibition of HDAC5/LSD1 exhibited similar effects on expression of HDAC5/LSD1 target genes.	sulforaphane	20-32	histone deacetylase 5	Homo sapiens	47-52
29633255-8	2018	shRNA knockdown and sulforaphane inhibition of HDAC5/LSD1 exhibited similar effects on expression of HDAC5/LSD1 target genes.	sulforaphane	20-32	lysine demethylase 1A	Homo sapiens	53-57
29633255-8	2018	shRNA knockdown and sulforaphane inhibition of HDAC5/LSD1 exhibited similar effects on expression of HDAC5/LSD1 target genes.	sulforaphane	20-32	histone deacetylase 5	Homo sapiens	101-106
30063917-13	2018	The present findings suggest that intervention with SFN, a naturally occurring isothiocyanate, has the potential to improve leptin responsiveness in DIO.	sulforaphane	52-55	leptin	Mus musculus	124-130
30086367-0	2018	Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway.	sulforaphane	0-12	brain derived neurotrophic factor	Mus musculus	112-116
29633255-8	2018	shRNA knockdown and sulforaphane inhibition of HDAC5/LSD1 exhibited similar effects on expression of HDAC5/LSD1 target genes.	sulforaphane	20-32	lysine demethylase 1A	Homo sapiens	107-111
29633255-9	2018	We also showed that coordinated cross-talk of HDAC5 and LSD1 is essential for the antitumor efficacy of sulforaphane.	sulforaphane	104-116	histone deacetylase 5	Homo sapiens	46-51
29633255-9	2018	We also showed that coordinated cross-talk of HDAC5 and LSD1 is essential for the antitumor efficacy of sulforaphane.	sulforaphane	104-116	lysine demethylase 1A	Homo sapiens	56-60
29633255-10	2018	Combination treatment with sulforaphane and a potent LSD1 inhibitor resulted in synergistic growth inhibition in breast cancer cells, but not in normal breast epithelial cells.	sulforaphane	27-39	lysine demethylase 1A	Homo sapiens	53-57
29633255-13	2018	Inhibition of HDAC5-LSD1 axis with sulforaphane blocks breast cancer growth and combined treatment with LSD1 inhibitor improves the therapeutic efficacy of sulforaphane.	sulforaphane	35-47	histone deacetylase 5	Homo sapiens	14-19
29633255-13	2018	Inhibition of HDAC5-LSD1 axis with sulforaphane blocks breast cancer growth and combined treatment with LSD1 inhibitor improves the therapeutic efficacy of sulforaphane.	sulforaphane	35-47	lysine demethylase 1A	Homo sapiens	20-24
30086367-0	2018	Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway.	sulforaphane	0-12	mechanistic target of rapamycin kinase	Mus musculus	117-121
29633255-13	2018	Inhibition of HDAC5-LSD1 axis with sulforaphane blocks breast cancer growth and combined treatment with LSD1 inhibitor improves the therapeutic efficacy of sulforaphane.	sulforaphane	156-168	histone deacetylase 5	Homo sapiens	14-19
30086367-6	2018	Furthermore, we found that ANA-12 (a TrkB inhibitor) or rapamycin (a mTOR inhibitor) could block the beneficial effects of SFN on LPS-induced cognitive dysfunction, and that hippocampal levels of synaptic proteins, BDNF-TrkB and mTOR signaling pathways were also notably changed.	sulforaphane	123-126	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	37-41
29633255-13	2018	Inhibition of HDAC5-LSD1 axis with sulforaphane blocks breast cancer growth and combined treatment with LSD1 inhibitor improves the therapeutic efficacy of sulforaphane.	sulforaphane	156-168	lysine demethylase 1A	Homo sapiens	104-108
30086367-6	2018	Furthermore, we found that ANA-12 (a TrkB inhibitor) or rapamycin (a mTOR inhibitor) could block the beneficial effects of SFN on LPS-induced cognitive dysfunction, and that hippocampal levels of synaptic proteins, BDNF-TrkB and mTOR signaling pathways were also notably changed.	sulforaphane	123-126	mechanistic target of rapamycin kinase	Mus musculus	69-73
30086367-7	2018	In conclusion, the results of the present study suggest that SFN could elicit improving effects on LPS-induced spatial learning and memory dysfunction, which is likely related to the regulation of hippocampal BDNF-mTOR signaling pathway.	sulforaphane	61-64	brain derived neurotrophic factor	Mus musculus	209-213
30086367-7	2018	In conclusion, the results of the present study suggest that SFN could elicit improving effects on LPS-induced spatial learning and memory dysfunction, which is likely related to the regulation of hippocampal BDNF-mTOR signaling pathway.	sulforaphane	61-64	mechanistic target of rapamycin kinase	Mus musculus	214-218
29924908-3	2018	METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally related long-chain isothiocyanates (ITCs) decreased histone deacetylase 3 (HDAC3) expression and increased pH2AX levels markedly in adenomatous colon polyps, extending prior observations on HDAC3 inhibition/turnover in cell-based assays.	sulforaphane	95-98	histone deacetylase 3	Rattus norvegicus	168-189
29924908-3	2018	METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally related long-chain isothiocyanates (ITCs) decreased histone deacetylase 3 (HDAC3) expression and increased pH2AX levels markedly in adenomatous colon polyps, extending prior observations on HDAC3 inhibition/turnover in cell-based assays.	sulforaphane	95-98	histone deacetylase 3	Rattus norvegicus	191-196
29924908-3	2018	METHODS AND RESULTS: In the polyposis in rat colon (Pirc) model, single oral administration of SFN and structurally related long-chain isothiocyanates (ITCs) decreased histone deacetylase 3 (HDAC3) expression and increased pH2AX levels markedly in adenomatous colon polyps, extending prior observations on HDAC3 inhibition/turnover in cell-based assays.	sulforaphane	95-98	histone deacetylase 3	Rattus norvegicus	306-311
30148822-5	2018	Sulforaphane (SFN) was used to activate the Nrf2-ARE signaling pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
30158636-7	2018	Additionally, engagement of this pathway by 4-OI or the Nrf2 inducer sulforaphane is sufficient to repress STING expression and type I IFN production in cells from patients with STING-dependent interferonopathies.	sulforaphane	69-81	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
30158636-7	2018	Additionally, engagement of this pathway by 4-OI or the Nrf2 inducer sulforaphane is sufficient to repress STING expression and type I IFN production in cells from patients with STING-dependent interferonopathies.	sulforaphane	69-81	stimulator of interferon response cGAMP interactor 1	Homo sapiens	107-112
30158636-7	2018	Additionally, engagement of this pathway by 4-OI or the Nrf2 inducer sulforaphane is sufficient to repress STING expression and type I IFN production in cells from patients with STING-dependent interferonopathies.	sulforaphane	69-81	stimulator of interferon response cGAMP interactor 1	Homo sapiens	178-183
30148822-5	2018	Sulforaphane (SFN) was used to activate the Nrf2-ARE signaling pathway.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
30148822-8	2018	Furthermore, the Nrf2, NQO1, and HO-1 mRNA and protein levels were higher in the small intestines of the SFN group than in the control group (p<0.05, n=4).	sulforaphane	105-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
30148822-8	2018	Furthermore, the Nrf2, NQO1, and HO-1 mRNA and protein levels were higher in the small intestines of the SFN group than in the control group (p<0.05, n=4).	sulforaphane	105-108	NAD(P)H dehydrogenase, quinone 1	Mus musculus	23-27
30148822-8	2018	Furthermore, the Nrf2, NQO1, and HO-1 mRNA and protein levels were higher in the small intestines of the SFN group than in the control group (p<0.05, n=4).	sulforaphane	105-108	heme oxygenase 1	Mus musculus	33-37
29924910-2	2018	The ITC l-sulforaphane (l-SFN) is the principle agent in broccoli that demonstrates several modes of anticancer action.	sulforaphane	8-22	RNA exonuclease 2	Homo sapiens	26-29
29885333-11	2018	In untransformed BEAS-2BR cells, sulforaphane, a natural compound, increased autophagy, activated Nrf2, and decreased ROS.	sulforaphane	33-45	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
29969714-3	2018	One of the most promising Nrf2 activators is sulforaphane, the subject of over 50 clinical trials.	sulforaphane	45-57	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
29969714-4	2018	In this work, we examine the effect of reactive oxygen species (ROS) on sulforaphane"s Nrf2/ARE activation in the non-tumorigenic keratinocyte cell line HaCaT, with the non-arylating oxidizable phenol, 2,5-di-tert-butylhydroquinone (dtBHQ), as the source of ROS.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
29969714-5	2018	We find that, in combination with 2.5 microM sulforaphane, dtBHQ markedly enhances ARE-regulated gene expression, including expression of the cytoprotective proteins aldo-keto reductase family 1 member C1 (AKR1C1) and heme oxygenase-1 (HO-1).	sulforaphane	45-57	aldo-keto reductase family 1 member C1	Homo sapiens	166-204
29969714-5	2018	We find that, in combination with 2.5 microM sulforaphane, dtBHQ markedly enhances ARE-regulated gene expression, including expression of the cytoprotective proteins aldo-keto reductase family 1 member C1 (AKR1C1) and heme oxygenase-1 (HO-1).	sulforaphane	45-57	aldo-keto reductase family 1 member C1	Homo sapiens	206-212
29969714-8	2018	While sulforaphane treatment causes Nrf2 protein to accumulate as expected, interestingly, dtBHQ and H2O2 appear to act on targets downstream of Nrf2 protein accumulation to enhance sulforaphane"s ARE-regulated gene expression.	sulforaphane	6-18	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
29969714-8	2018	While sulforaphane treatment causes Nrf2 protein to accumulate as expected, interestingly, dtBHQ and H2O2 appear to act on targets downstream of Nrf2 protein accumulation to enhance sulforaphane"s ARE-regulated gene expression.	sulforaphane	182-194	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
29969714-8	2018	While sulforaphane treatment causes Nrf2 protein to accumulate as expected, interestingly, dtBHQ and H2O2 appear to act on targets downstream of Nrf2 protein accumulation to enhance sulforaphane"s ARE-regulated gene expression.	sulforaphane	182-194	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
29969714-11	2018	Inclusion of a superoxide dismutase mimetic with sulforaphane and dtBHQ partly rescues Nrf2 suppression and significantly further increases sulforaphane"s efficacy for ARE-reporter expression.	sulforaphane	49-61	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
29969714-12	2018	Thus, there is a "Dr. Jekyll and Mr. Hyde" effect of ROS: ROS enhance sulforaphane"s ARE-regulated gene expression even as they also inhibit Nrf2 protein synthesis.	sulforaphane	70-82	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
29885333-12	2018	In cadmium-transformed BEAS-2BR cells, sulforaphane restored autophagy, decreased Nrf2, and decreased apoptosis resistance.	sulforaphane	39-51	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
29885333-13	2018	In untransformed cells, this sulforaphane induced inducible Nrf2 to decrease ROS and possibly malignant cell transformation.	sulforaphane	29-41	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
29772437-5	2018	The Nrf2 protein expression in the 1-h groups was 17% higher than in the 24-h groups, and the SFN + H2O2 group had 40% more Nrf2 than the Control in the 1-h groups.	sulforaphane	94-97	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
30135655-0	2018	Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane.	sulforaphane	112-124	Kelch-like ECH-associated protein 1	Rattus norvegicus	8-13
30135655-2	2018	Accumulating studies have shown the beneficial effects of the natural compound sulforaphane (SFN), an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), on depression-like phenotype through a potent anti-inflammatory effect.	sulforaphane	79-91	NFE2 like bZIP transcription factor 2	Rattus norvegicus	160-164
30135655-2	2018	Accumulating studies have shown the beneficial effects of the natural compound sulforaphane (SFN), an activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), on depression-like phenotype through a potent anti-inflammatory effect.	sulforaphane	93-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	160-164
29772437-9	2018	The different responses in the expression of Nrf2 and PGC-1alpha in relation to the incubation times, draws attention to the importance of establishing a timeline of the action of SFN, since there appears to be a temporal difference in its mechanism in adult cardiomyocytes.	sulforaphane	180-183	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
29772437-9	2018	The different responses in the expression of Nrf2 and PGC-1alpha in relation to the incubation times, draws attention to the importance of establishing a timeline of the action of SFN, since there appears to be a temporal difference in its mechanism in adult cardiomyocytes.	sulforaphane	180-183	PPARG coactivator 1 alpha	Homo sapiens	54-64
29764806-2	2018	An important risk factor for breast cancer is individual genetic background, which is initially generated early in human life, for example, during the processes of embryogenesis and fetal development in utero Bioactive dietary components such as sulforaphane (SFN), an isothiocyanate from cruciferous vegetables including broccoli sprouts (BSp), cabbage, and kale, has been shown to reduce the risk of developing many common cancers through regulation of epigenetic mechanisms.	sulforaphane	246-258	integrin binding sialoprotein	Homo sapiens	340-343
29704151-12	2018	Treatment of sulforaphane, likewise, decreased sciatic nerve malondialdehyde, nitric oxide, interleukin-6, and matrix metalloproteinase-2 and -9 contents.	sulforaphane	13-25	interleukin 6	Rattus norvegicus	92-105
29704151-12	2018	Treatment of sulforaphane, likewise, decreased sciatic nerve malondialdehyde, nitric oxide, interleukin-6, and matrix metalloproteinase-2 and -9 contents.	sulforaphane	13-25	matrix metallopeptidase 2	Rattus norvegicus	111-144
29704151-19	2018	Treatment of sulforaphane, likewise, decreased sciatic nerve malondialdehyde, nitric oxide, interleukin-6, matrix metalloproteinase-2 and -9 contents.	sulforaphane	13-25	interleukin 6	Rattus norvegicus	92-105
29704151-19	2018	Treatment of sulforaphane, likewise, decreased sciatic nerve malondialdehyde, nitric oxide, interleukin-6, matrix metalloproteinase-2 and -9 contents.	sulforaphane	13-25	matrix metallopeptidase 2	Rattus norvegicus	107-140
28562170-6	2018	However, by adding sulforaphane the PEDF mRNA expression increased significantly p < .000032.	sulforaphane	19-31	serpin family F member 1	Homo sapiens	36-40
28562170-9	2018	The antioxidant stimulating substance sulforaphane contribute to an increase in PEDF mRNA in fetal membranes.	sulforaphane	38-50	serpin family F member 1	Homo sapiens	80-84
29473125-0	2018	Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	114-118
29473125-0	2018	Sulforaphane Attenuated the Pro-Inflammatory State Induced by Hydrogen Peroxide in SH-SY5Y Cells Through the Nrf2/HO-1 Signaling Pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	28-31	interleukin 1 beta	Homo sapiens	171-179
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	interleukin 1 beta	Homo sapiens	152-169
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	interleukin 1 beta	Homo sapiens	171-179
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	tumor necrosis factor	Homo sapiens	185-212
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	tumor necrosis factor	Homo sapiens	214-223
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	261-277
29473125-5	2018	The cells were treated with SFN at 5 muM for 30 min before a challenge with H2O2 for an additional 24 h. Pretreatment with SFN reduced the secretion of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as decreased the levels of cyclooxygenase-2 (COX-2) in H2O2-treated cells.	sulforaphane	123-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	279-284
29792947-0	2018	TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells.	sulforaphane	17-29	TNF superfamily member 10	Homo sapiens	0-5
29792947-0	2018	TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells.	sulforaphane	17-29	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
29792947-7	2018	Interestingly, TRAIL effectively suppressed SFN-mediated nuclear translocation of Nrf2, and the period of ROS generation was more extended compared to that of treatment with SFN alone.	sulforaphane	44-47	TNF superfamily member 10	Homo sapiens	15-20
29792947-0	2018	TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells.	sulforaphane	17-29	TNF superfamily member 10	Homo sapiens	97-102
29792947-7	2018	Interestingly, TRAIL effectively suppressed SFN-mediated nuclear translocation of Nrf2, and the period of ROS generation was more extended compared to that of treatment with SFN alone.	sulforaphane	44-47	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
29792947-9	2018	These data suggest that SFN-induced ROS generation promotes TRAIL sensitivity and SFN can be used for the management of TRAIL-resistant cancer.	sulforaphane	24-27	TNF superfamily member 10	Homo sapiens	60-65
29792947-3	2018	Here, we report that TRAIL resistance can be reversed in human bladder cancer cell lines by treatment with sulforaphane (SFN), a well-known chemopreventive isothiocyanate in various cruciferous vegetables.	sulforaphane	107-119	TNF superfamily member 10	Homo sapiens	21-26
29792947-9	2018	These data suggest that SFN-induced ROS generation promotes TRAIL sensitivity and SFN can be used for the management of TRAIL-resistant cancer.	sulforaphane	24-27	TNF superfamily member 10	Homo sapiens	120-125
29792947-3	2018	Here, we report that TRAIL resistance can be reversed in human bladder cancer cell lines by treatment with sulforaphane (SFN), a well-known chemopreventive isothiocyanate in various cruciferous vegetables.	sulforaphane	121-124	TNF superfamily member 10	Homo sapiens	21-26
29792947-4	2018	Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5.	sulforaphane	24-27	TNF superfamily member 10	Homo sapiens	43-48
29792947-4	2018	Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5.	sulforaphane	24-27	BH3 interacting domain death agonist	Homo sapiens	171-174
29792947-4	2018	Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5.	sulforaphane	24-27	TNF receptor superfamily member 10b	Homo sapiens	204-220
29792947-4	2018	Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5.	sulforaphane	39-42	TNF superfamily member 10	Homo sapiens	32-37
29792947-4	2018	Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5.	sulforaphane	39-42	BH3 interacting domain death agonist	Homo sapiens	171-174
29792947-4	2018	Combined treatment with SFN and TRAIL (SFN/TRAIL) significantly induced apoptosis concomitant with activation of caspases, loss of mitochondrial membrane potential (MMP), Bid truncation, and induction of death receptor 5.	sulforaphane	39-42	TNF receptor superfamily member 10b	Homo sapiens	204-220
29792947-5	2018	Transient knockdown of Bid prevented collapse of MMP induced by SFN/TRAIL, consequently reducing apoptotic effects.	sulforaphane	64-67	BH3 interacting domain death agonist	Homo sapiens	23-26
30029485-0	2018	Protective Mechanism of Sulforaphane on Cadmium-Induced Sertoli Cell Injury in Mice Testis via Nrf2/ARE Signaling Pathway.	sulforaphane	24-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
30029485-8	2018	Taken together, SFN could improve the antioxidant capacity of Sertoli cells, and exert a protective effect on the oxidative damage and apoptosis of Cd-induced Sertoli cells through the activation of Nrf2/ARE signal transduction pathway.	sulforaphane	16-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	199-203
29391237-0	2018	Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-kappaB signaling pathways in LPS-activated BV-2 microglia.	sulforaphane	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
29677532-3	2018	Moreover, SF inhibits proliferation and induces apoptosis decreasing the stemness of nasopharyngeal cancer cells through a mechanism related to STAT3 signaling in vitro.	sulforaphane	10-12	signal transducer and activator of transcription 3	Homo sapiens	144-149
29427794-5	2018	The focus of this review is to provide a detailed analysis of the known mechanisms by which SFN modulates Nrf2, NFkappaB and PPARgamma signaling and crosstalk and to provide a critical evaluation of the evidence linking these transcriptional pathways with diabetic and cardiometabolic complications and SFN mediated cytoprotection.	sulforaphane	92-95	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
29427794-5	2018	The focus of this review is to provide a detailed analysis of the known mechanisms by which SFN modulates Nrf2, NFkappaB and PPARgamma signaling and crosstalk and to provide a critical evaluation of the evidence linking these transcriptional pathways with diabetic and cardiometabolic complications and SFN mediated cytoprotection.	sulforaphane	92-95	nuclear factor kappa B subunit 1	Homo sapiens	112-120
29427794-5	2018	The focus of this review is to provide a detailed analysis of the known mechanisms by which SFN modulates Nrf2, NFkappaB and PPARgamma signaling and crosstalk and to provide a critical evaluation of the evidence linking these transcriptional pathways with diabetic and cardiometabolic complications and SFN mediated cytoprotection.	sulforaphane	92-95	peroxisome proliferator activated receptor gamma	Homo sapiens	125-134
29427794-6	2018	To allow comparison between rodent and human studies, we discuss the published bioavailability of SFN metabolites achieved in rodents and man in the context of Nrf2, NFkappaB and PPARgamma signaling.	sulforaphane	98-101	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
29427794-6	2018	To allow comparison between rodent and human studies, we discuss the published bioavailability of SFN metabolites achieved in rodents and man in the context of Nrf2, NFkappaB and PPARgamma signaling.	sulforaphane	98-101	nuclear factor kappa B subunit 1	Homo sapiens	166-174
29427794-6	2018	To allow comparison between rodent and human studies, we discuss the published bioavailability of SFN metabolites achieved in rodents and man in the context of Nrf2, NFkappaB and PPARgamma signaling.	sulforaphane	98-101	peroxisome proliferator activated receptor gamma	Homo sapiens	179-188
29684505-0	2018	Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
29684505-2	2018	Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
29684505-2	2018	Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
29684505-2	2018	Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
29684505-2	2018	Sulforaphane (SFN) is a pharmacological activator of Nrf2 that provokes Nrf2-mediated intracellular defenses, including antioxidant and anti-inflammatory responses, under oxidative stress (OS) conditions.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
28730528-0	2018	Sulforaphane Promotes Mitochondrial Protection in SH-SY5Y Cells Exposed to Hydrogen Peroxide by an Nrf2-Dependent Mechanism.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
29525530-0	2018	Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells.	sulforaphane	0-12	microRNA 9-3	Homo sapiens	62-69
29525530-0	2018	Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells.	sulforaphane	0-12	microRNA 9-3	Homo sapiens	95-102
29525530-4	2018	In this study, we aimed to investigate the effect of SFN on restoring the miR-9-3 level in lung cancer A549 cells through epigenetic regulation.	sulforaphane	53-56	microRNA 9-3	Homo sapiens	74-81
29525530-8	2018	We found that CpG methylation was reduced in the miR-9-3 promoter and that miR-9-3 expression was increased after 5 days of treatment with SFN.	sulforaphane	139-142	microRNA 9-3	Homo sapiens	49-56
29525530-8	2018	We found that CpG methylation was reduced in the miR-9-3 promoter and that miR-9-3 expression was increased after 5 days of treatment with SFN.	sulforaphane	139-142	microRNA 9-3	Homo sapiens	75-82
29525530-12	2018	Taken together, these findings indicate that SFN may exert its chemopreventive effects partly through epigenetic demethylation and restoration of miR-9-3.	sulforaphane	45-48	microRNA 9-3	Homo sapiens	146-153
29977456-0	2018	Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway.	sulforaphane	23-35	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
29977456-3	2018	SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN.	sulforaphane	0-3	nuclear factor, erythroid 2	Homo sapiens	68-94
29977456-3	2018	SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
29977456-3	2018	SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	205-209
29977456-3	2018	SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN.	sulforaphane	274-277	nuclear factor, erythroid 2	Homo sapiens	68-94
29977456-3	2018	SFN also upregulates a series of cytoprotective genes by activating nuclear factor erythroid-2- (NF-E2-) related factor 2 (Nrf2), a critical transcription factor activated in response to oxidative stress; Nrf2 activation is also involved in the cancer-preventive effects of SFN.	sulforaphane	274-277	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
29714053-0	2018	Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-beta and Tau in a Mouse Model of Alzheimer"s Disease.	sulforaphane	0-12	microtubule associated protein tau	Homo sapiens	94-97
29714053-2	2018	Here, the authors investigate whether sulforaphane modulates the production of amyloid-beta (Abeta) and tau, the two main pathological factors in Alzheimer"s disease (AD).	sulforaphane	38-50	amyloid beta (A4) precursor protein	Mus musculus	93-98
29714053-2	2018	Here, the authors investigate whether sulforaphane modulates the production of amyloid-beta (Abeta) and tau, the two main pathological factors in Alzheimer"s disease (AD).	sulforaphane	38-50	microtubule associated protein tau	Homo sapiens	104-107
29714053-4	2018	Oral gavage of sulforaphane reduces protein levels of monomeric and polymeric forms of Abeta as well as tau and phosphorylated tau in 3 x Tg-AD mice.	sulforaphane	15-27	amyloid beta (A4) precursor protein	Mus musculus	87-92
29714053-4	2018	Oral gavage of sulforaphane reduces protein levels of monomeric and polymeric forms of Abeta as well as tau and phosphorylated tau in 3 x Tg-AD mice.	sulforaphane	15-27	microtubule associated protein tau	Homo sapiens	104-107
29714053-4	2018	Oral gavage of sulforaphane reduces protein levels of monomeric and polymeric forms of Abeta as well as tau and phosphorylated tau in 3 x Tg-AD mice.	sulforaphane	15-27	microtubule associated protein tau	Homo sapiens	127-130
29714053-7	2018	The authors find that sulforaphane treatment increase levels of CHIP and HSP70.	sulforaphane	22-34	heat shock protein 1B	Mus musculus	73-78
29714053-8	2018	Furthermore, observations of CHIP-deficient primary neurons derived from 3 x Tg-AD mice suggest that sulforaphane treatment increase CHIP level and clear the accumulation of Abeta and tau.	sulforaphane	101-113	amyloid beta (A4) precursor protein	Mus musculus	174-179
29714053-8	2018	Furthermore, observations of CHIP-deficient primary neurons derived from 3 x Tg-AD mice suggest that sulforaphane treatment increase CHIP level and clear the accumulation of Abeta and tau.	sulforaphane	101-113	microtubule associated protein tau	Homo sapiens	184-187
29714053-10	2018	CONCLUSION: These results demonstrate that sulforaphane treatment upregulates CHIP and has the potential to decrease the accumulation of Abeta and tau in patients with AD.	sulforaphane	43-55	amyloid beta precursor protein	Homo sapiens	137-142
29582250-6	2018	Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin, and sulforaphane downregulate the WNT/beta-catenin pathway through the upregulation of PPAR-gamma and thus appear to provide an interesting therapeutic approach for gliomas.	sulforaphane	86-98	catenin beta 1	Homo sapiens	120-132
29582250-6	2018	Nonsteroidal anti-inflammatory drugs, curcumin, antipsychotic drugs, adiponectin, and sulforaphane downregulate the WNT/beta-catenin pathway through the upregulation of PPAR-gamma and thus appear to provide an interesting therapeutic approach for gliomas.	sulforaphane	86-98	peroxisome proliferator activated receptor gamma	Homo sapiens	169-179
29714053-10	2018	CONCLUSION: These results demonstrate that sulforaphane treatment upregulates CHIP and has the potential to decrease the accumulation of Abeta and tau in patients with AD.	sulforaphane	43-55	microtubule associated protein tau	Homo sapiens	147-150
29668854-2	2018	We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice.	sulforaphane	53-65	tumor necrosis factor receptor superfamily, member 25	Mus musculus	204-247
29668854-2	2018	We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice.	sulforaphane	53-65	tumor necrosis factor receptor superfamily, member 25	Mus musculus	249-254
29668854-2	2018	We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice.	sulforaphane	67-70	tumor necrosis factor receptor superfamily, member 25	Mus musculus	204-247
29668854-2	2018	We have shown previously that oral administration of sulforaphane (SFN) significantly inhibits the incidence and/or burden of prostatic intraepithelial neoplasia and well-differentiated adenocarcinoma in TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice.	sulforaphane	67-70	tumor necrosis factor receptor superfamily, member 25	Mus musculus	249-254
29668854-3	2018	The present study used cellular models of prostate cancer and archived plasma/adenocarcinoma tissues and sections from the TRAMP study to demonstrate inhibition of fatty acid synthesis by SFN treatment in vitro and in vivo.	sulforaphane	188-191	tumor necrosis factor receptor superfamily, member 25	Mus musculus	123-128
29668854-6	2018	Immunohistochemistry revealed a significant decrease in expression of FASN and ACC1 proteins in prostate adenocarcinoma sections of SFN-treated TRAMP mice when compared with controls.	sulforaphane	132-135	fatty acid synthase	Mus musculus	70-74
29668854-6	2018	Immunohistochemistry revealed a significant decrease in expression of FASN and ACC1 proteins in prostate adenocarcinoma sections of SFN-treated TRAMP mice when compared with controls.	sulforaphane	132-135	acetyl-Coenzyme A carboxylase alpha	Mus musculus	79-83
29668854-6	2018	Immunohistochemistry revealed a significant decrease in expression of FASN and ACC1 proteins in prostate adenocarcinoma sections of SFN-treated TRAMP mice when compared with controls.	sulforaphane	132-135	tumor necrosis factor receptor superfamily, member 25	Mus musculus	144-149
29668854-7	2018	SFN administration to TRAMP mice resulted in a significant decrease in plasma and/or prostate adenocarcinoma levels of total free fatty acids, total phospholipids, acetyl-CoA and ATP.	sulforaphane	0-3	tumor necrosis factor receptor superfamily, member 25	Mus musculus	22-27
29668854-8	2018	Consistent with these results, number of neutral lipid droplets was lower in the prostate adenocarcinoma sections of SFN-treated TRAMP mice than in control tumors.	sulforaphane	117-120	tumor necrosis factor receptor superfamily, member 25	Mus musculus	129-134
29668854-9	2018	Collectively, these observations indicate that prostate cancer chemoprevention by SFN in TRAMP mice is associated with inhibition of fatty acid metabolism.	sulforaphane	82-85	tumor necrosis factor receptor superfamily, member 25	Mus musculus	89-94
29277538-5	2018	In male Krt16-/- mice, oxidative stress associated with impaired glutathione synthesis and nuclear factor erythroid-derived 2 related factor 2 (NRF2)-dependent gene expression precedes PPK onset, which can be prevented by topical sulforaphane-mediated activation of NRF2.	sulforaphane	230-242	nuclear factor, erythroid derived 2, like 2	Mus musculus	266-270
29530794-7	2018	Sulforaphane-induced activation of the Nrf2 signaling pathway alleviated morphological alterations, mitochondrial dysfunction in dorsal root ganglion neurons, and nociceptive sensations in mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	39-43
29747418-7	2018	The activation of the nuclear factor E2-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway and the induction of intracellular glutathione (GSH) played an important role in the cytoprotective effects of SFN metabolites.	sulforaphane	218-221	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
29482060-0	2018	Inhibition of class IIa histone deacetylase activity by gallic acid, sulforaphane, TMP269, and panobinostat.	sulforaphane	69-81	ATPase, class II, type 9A	Mus musculus	20-23
28001083-0	2018	Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.	sulforaphane	18-30	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
28001083-6	2018	At molecular level, sulforaphane modulates cellular homeostasis via the activation of the transcription factor Nrf2.	sulforaphane	20-32	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
29716531-12	2018	We discovered interesting differences in the sensitivity to chemotherapeutic drugs (Temozolomide, Withaferin A and Sulforaphane) between the PAX6 expressing and non-expressing cells.	sulforaphane	115-127	paired box 6	Homo sapiens	141-145
29482060-6	2018	Among the three phytochemicals, gallic acid showed remarkable inhibition, whereas sulforaphane presented mild inhibition of class IIa HDACs.	sulforaphane	82-94	ATPase, class II, type 9A	Mus musculus	130-133
29482060-12	2018	Inhibition of HDAC2 activity by sulforaphane was stronger than that by piceatnnaol.	sulforaphane	32-44	histone deacetylase 2	Mus musculus	14-19
29482060-14	2018	Sulforaphane may also be used as a dietary inhibitor of HDAC2 and class IIa HDAC.	sulforaphane	0-12	histone deacetylase 2	Mus musculus	56-61
29482060-14	2018	Sulforaphane may also be used as a dietary inhibitor of HDAC2 and class IIa HDAC.	sulforaphane	0-12	ATPase, class II, type 9A	Mus musculus	72-75
29482060-14	2018	Sulforaphane may also be used as a dietary inhibitor of HDAC2 and class IIa HDAC.	sulforaphane	0-12	histone deacetylase 6	Mus musculus	56-60
29277538-8	2018	Dual treatment with sulforaphane and diarylpropionitrile, an estrogen receptor beta selective agonist, results in NRF2 activation, normalization of glutathione levels, and prevention of PPK in female Krt16-/- mice.	sulforaphane	20-32	estrogen receptor 2 (beta)	Mus musculus	61-83
29277538-8	2018	Dual treatment with sulforaphane and diarylpropionitrile, an estrogen receptor beta selective agonist, results in NRF2 activation, normalization of glutathione levels, and prevention of PPK in female Krt16-/- mice.	sulforaphane	20-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
29277538-8	2018	Dual treatment with sulforaphane and diarylpropionitrile, an estrogen receptor beta selective agonist, results in NRF2 activation, normalization of glutathione levels, and prevention of PPK in female Krt16-/- mice.	sulforaphane	20-32	keratin 16	Mus musculus	200-205
29353218-8	2018	In vitro up-regulation of Nrf2 by SFN was abolished and nuclear Fyn accumulation was increased when cardiac cells were exposed to a PI3K inhibitor or GSK-3beta-specific activator.	sulforaphane	34-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	26-30
29353218-0	2018	Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ss/Fyn pathway.	sulforaphane	0-12	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	22-36
28863281-5	2018	Upon exposure to the Nrf2 activator, sulforaphane (SF), the expression of these antioxidant genes was increased in cells from both the young adults and the older donors; however, the induction by SF in older donor cells was significantly less than that seen in young adult cells.	sulforaphane	37-49	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
29353218-0	2018	Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ss/Fyn pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
29353218-0	2018	Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ss/Fyn pathway.	sulforaphane	0-12	thymoma viral proto-oncogene 1	Mus musculus	102-105
29353218-0	2018	Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ss/Fyn pathway.	sulforaphane	0-12	glycogen synthase kinase 3 beta	Mus musculus	106-111
29353218-0	2018	Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ss/Fyn pathway.	sulforaphane	0-12	Fyn proto-oncogene	Mus musculus	114-117
29353218-1	2018	AIMS: Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy.	sulforaphane	74-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-63
29353218-1	2018	AIMS: Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy.	sulforaphane	74-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
29353218-1	2018	AIMS: Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy.	sulforaphane	88-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	20-63
29353218-1	2018	AIMS: Activation of nuclear factor erythroid 2-related factor 2 (Nrf2) by sulforaphane (SFN) protects from, and deletion of the Nrf2 gene exaggerates, diabetic cardiomyopathy.	sulforaphane	88-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
29353218-3	2018	Therefore, whether SFN prevents Ang II-induced cardiomyopathy through activation of Nrf2 was examined using wild-type, global deletion of Nrf2 gene (Nrf2-KO) and cardiomyocyte-specific overexpression of Nrf2 gene (Nrf2-TG) mice.	sulforaphane	19-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
29353218-4	2018	METHODS AND RESULTS: Administration of a subpressor dose of Ang II to wild-type mice induced cardiac oxidative stress, inflammation, remodeling and dysfunction, all of which could be prevented by SFN treatment with Nrf2 up-regulation and activation.	sulforaphane	196-199	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	60-66
29353218-4	2018	METHODS AND RESULTS: Administration of a subpressor dose of Ang II to wild-type mice induced cardiac oxidative stress, inflammation, remodeling and dysfunction, all of which could be prevented by SFN treatment with Nrf2 up-regulation and activation.	sulforaphane	196-199	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-219
29353218-6	2018	Meanwhile, the ability of SFN to protect against Ang II-induced cardiac damage was lost in Nrf2-KO mice.	sulforaphane	26-29	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	49-55
29353218-6	2018	Meanwhile, the ability of SFN to protect against Ang II-induced cardiac damage was lost in Nrf2-KO mice.	sulforaphane	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	91-95
29353218-7	2018	Up-regulation and activation of Nrf2 by SFN is accompanied by activation of Akt, inhibition of glycogen synthase kinase (GSK)-3beta, and accumulation of Fyn in nuclei.	sulforaphane	40-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
29353218-7	2018	Up-regulation and activation of Nrf2 by SFN is accompanied by activation of Akt, inhibition of glycogen synthase kinase (GSK)-3beta, and accumulation of Fyn in nuclei.	sulforaphane	40-43	thymoma viral proto-oncogene 1	Mus musculus	76-79
29353218-7	2018	Up-regulation and activation of Nrf2 by SFN is accompanied by activation of Akt, inhibition of glycogen synthase kinase (GSK)-3beta, and accumulation of Fyn in nuclei.	sulforaphane	40-43	glycogen synthase kinase 3 beta	Mus musculus	95-131
29353218-7	2018	Up-regulation and activation of Nrf2 by SFN is accompanied by activation of Akt, inhibition of glycogen synthase kinase (GSK)-3beta, and accumulation of Fyn in nuclei.	sulforaphane	40-43	Fyn proto-oncogene	Mus musculus	153-156
29382536-0	2018	Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer"s disease.	sulforaphane	35-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-31
29382536-1	2018	Sulforaphane was reported to exert neuroprotective effects via upregulating expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and has received increasing attention as an alternative candidate for treatment of Alzheimer"s disease (AD).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-133
29382536-1	2018	Sulforaphane was reported to exert neuroprotective effects via upregulating expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and has received increasing attention as an alternative candidate for treatment of Alzheimer"s disease (AD).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
29382536-2	2018	However, the mechanism to account for Nrf2 upregulation by sulforaphane in AD remains unknown.	sulforaphane	59-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-42
29382536-3	2018	Herein, we found that sulforaphane upregulated Nrf2 expression and promoted Nrf2 nuclear translocation via decreasing DNA methylation levels of the Nrf2 promoter in mouse neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (N2a/APPswe cells), a cellular model of AD.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51
29382536-3	2018	Herein, we found that sulforaphane upregulated Nrf2 expression and promoted Nrf2 nuclear translocation via decreasing DNA methylation levels of the Nrf2 promoter in mouse neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (N2a/APPswe cells), a cellular model of AD.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
29382536-3	2018	Herein, we found that sulforaphane upregulated Nrf2 expression and promoted Nrf2 nuclear translocation via decreasing DNA methylation levels of the Nrf2 promoter in mouse neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (N2a/APPswe cells), a cellular model of AD.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
29382536-6	2018	Our study suggested that sulforaphane upregulated the expression of Nrf2 and promoted the nuclear translocation of Nrf2 by decreasing DNA demethylation levels of the Nrf2 promoter, thus leading to antioxidative and anti-inflammatory effects in a cellular model of AD.	sulforaphane	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
29382536-6	2018	Our study suggested that sulforaphane upregulated the expression of Nrf2 and promoted the nuclear translocation of Nrf2 by decreasing DNA demethylation levels of the Nrf2 promoter, thus leading to antioxidative and anti-inflammatory effects in a cellular model of AD.	sulforaphane	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
29382536-6	2018	Our study suggested that sulforaphane upregulated the expression of Nrf2 and promoted the nuclear translocation of Nrf2 by decreasing DNA demethylation levels of the Nrf2 promoter, thus leading to antioxidative and anti-inflammatory effects in a cellular model of AD.	sulforaphane	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
29707130-4	2018	Moreover, sulforaphane increased microtubule-associated protein 1 light chain 3 (LC3) conversion, and the knockdown of LC3 by siRNA increased cell migration ability.	sulforaphane	10-22	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	81-84
29707130-5	2018	Regarding the mechanism, sulforaphane inhibited the cell motility of oral cancer cells through the extracellular signal-regulated kinase (ERK) pathway, which in turn reversed cell motility.	sulforaphane	25-37	mitogen-activated protein kinase 1	Homo sapiens	99-136
29707130-5	2018	Regarding the mechanism, sulforaphane inhibited the cell motility of oral cancer cells through the extracellular signal-regulated kinase (ERK) pathway, which in turn reversed cell motility.	sulforaphane	25-37	mitogen-activated protein kinase 1	Homo sapiens	138-141
29707130-6	2018	In conclusion, sulforaphane suppress cathepsin S expression by inducing autophage through ERK signaling pathway.	sulforaphane	15-27	mitogen-activated protein kinase 1	Homo sapiens	90-93
29405844-1	2018	Our study aimed to investigate the effect of bone morphogenetic protein-2 (BMP-2) bound to silk fibroin and beta-tricalcium phosphate (SF/beta-TCP) hybrid on the healing of critical-size radial defects in rabbits.	sulforaphane	135-137	bone morphogenetic protein 2	Oryctolagus cuniculus	45-73
29405844-1	2018	Our study aimed to investigate the effect of bone morphogenetic protein-2 (BMP-2) bound to silk fibroin and beta-tricalcium phosphate (SF/beta-TCP) hybrid on the healing of critical-size radial defects in rabbits.	sulforaphane	135-137	bone morphogenetic protein 2	Oryctolagus cuniculus	75-80
29695052-12	2018	SFN-treated animals presented down-regulation of CD11b and CD62L on synovial fluid Ly6G+ cells.	sulforaphane	0-3	integrin alpha M	Mus musculus	49-54
29695052-12	2018	SFN-treated animals presented down-regulation of CD11b and CD62L on synovial fluid Ly6G+ cells.	sulforaphane	0-3	selectin, lymphocyte	Mus musculus	59-64
29695052-12	2018	SFN-treated animals presented down-regulation of CD11b and CD62L on synovial fluid Ly6G+ cells.	sulforaphane	0-3	lymphocyte antigen 6 complex, locus G	Mus musculus	83-87
29609658-9	2018	The results confirmed that the expression of the epithelial marker, E-cadherin, increased after SFN treatment, while expression of the mesenchymal markers, N-cadherin, vimentin, and alpha-SMA decreased in A549 cells after SFN treatment.	sulforaphane	96-99	cadherin 1	Mus musculus	68-78
29609658-13	2018	BLM induced fibrosis in mouse lungs that was also attenuated by SFN treatment, and SFN treatment decreased BLM-induced fibronectin expression, TGF-beta1 expression, and the levels of collagen I in the lungs of mice.	sulforaphane	83-86	fibronectin 1	Mus musculus	119-130
29609658-13	2018	BLM induced fibrosis in mouse lungs that was also attenuated by SFN treatment, and SFN treatment decreased BLM-induced fibronectin expression, TGF-beta1 expression, and the levels of collagen I in the lungs of mice.	sulforaphane	83-86	transforming growth factor, beta 1	Mus musculus	143-152
29458149-6	2018	Sulforaphane treatment or overexpression of Slc7a11 was used to increase Slc7a11 in lung fibroblasts from old mice, and sulfasalazine treatment or siRNA-mediated knock down was used to decrease Slc7a11 in young fibroblasts.	sulforaphane	0-12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	73-80
29458149-6	2018	Sulforaphane treatment or overexpression of Slc7a11 was used to increase Slc7a11 in lung fibroblasts from old mice, and sulfasalazine treatment or siRNA-mediated knock down was used to decrease Slc7a11 in young fibroblasts.	sulforaphane	0-12	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	73-80
29458149-9	2018	Up-regulation of Slc7a11 via overexpression or sulforaphane treatment restored extracellular Eh(Cys/CySS) in cultures of old cells, whereas down-regulation reproduced the oxidizing Eh(Cys/CySS) in young cells.	sulforaphane	47-59	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	17-24
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	51-56
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	115-120
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	87-90	NLR family, pyrin domain containing 3	Mus musculus	51-56
29340626-8	2018	SFN inhibited ligand-independent activation of the NLRP3 inflammasome, suggesting that SFN may act directly on the NLRP3 inflammasome complex.	sulforaphane	87-90	NLR family, pyrin domain containing 3	Mus musculus	115-120
29340626-9	2018	Conclusion: Oral administration of SFN effectively alleviated acute gouty inflammation by suppression of the NLRP3 inflammasome.	sulforaphane	35-38	NLR family, pyrin domain containing 3	Mus musculus	109-114
28863281-5	2018	Upon exposure to the Nrf2 activator, sulforaphane (SF), the expression of these antioxidant genes was increased in cells from both the young adults and the older donors; however, the induction by SF in older donor cells was significantly less than that seen in young adult cells.	sulforaphane	51-53	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
29458173-8	2018	Interestingly, sulforaphane increased Akt activation and Nrf2 translocation to the nucleus in the DysKD myotubes.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
30263847-0	2018	SMYD3-associated pathway is involved in the anti-tumor effects of sulforaphane on gastric carcinoma cells.	sulforaphane	66-78	SET and MYND domain containing 3	Homo sapiens	0-5
30263847-4	2018	Accompanied with these anti-cancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN.	sulforaphane	171-174	SET and MYND domain containing 3	Homo sapiens	44-49
30263847-4	2018	Accompanied with these anti-cancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN.	sulforaphane	171-174	myosin light chain 9	Homo sapiens	76-107
30263847-4	2018	Accompanied with these anti-cancer effects, SMYD3 and its downstream genes, myosin regulatory light chain 9, and cysteine-rich angiogenic inducer 61, was downregulated by SFN.	sulforaphane	171-174	cellular communication network factor 1	Homo sapiens	113-148
30263847-5	2018	Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN.	sulforaphane	83-86	SET and MYND domain containing 3	Homo sapiens	31-36
30263847-5	2018	Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN.	sulforaphane	83-86	SET and MYND domain containing 3	Homo sapiens	104-109
30263847-5	2018	Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN.	sulforaphane	144-147	SET and MYND domain containing 3	Homo sapiens	31-36
30263847-5	2018	Furthermore, overexpression of SMYD3 via transfection could abolish the effects of SFN, suggesting that SMYD3 might be an important mediator of SFN.	sulforaphane	144-147	SET and MYND domain containing 3	Homo sapiens	104-109
30263847-6	2018	To the best of our knowledge, this is the first report describing the role of SMYD3 in the anti-cancer of SFN.	sulforaphane	106-109	SET and MYND domain containing 3	Homo sapiens	78-83
29340626-0	2018	Suppression of NLRP3 inflammasome by oral treatment with sulforaphane alleviates acute gouty inflammation.	sulforaphane	57-69	NLR family, pyrin domain containing 3	Mus musculus	15-20
29340626-5	2018	Results: Oral administration of SFN attenuated MSU crystal-induced swelling and neutrophil recruitment in a mouse foot acute gout model, correlating with the suppression of the NLRP3 inflammasome activation in foot tissues.	sulforaphane	32-35	NLR family, pyrin domain containing 3	Mus musculus	177-182
29340626-6	2018	Consistently, oral administration of SFN blocked MSU-crystal-induced activation of the NLRP3 inflammasome in a mouse air pouch gout model.	sulforaphane	37-40	NLR family, pyrin domain containing 3	Mus musculus	87-92
29472449-10	2018	Moreover, ER stress induced in pmm2it768 mutants was ameliorated by the treatment of the Nrf2-activator sulforaphane, indicating that Nrf2 plays significant roles in the reduction of ER stress.	sulforaphane	104-116	nfe2 like bZIP transcription factor 2a	Danio rerio	89-93
29472449-10	2018	Moreover, ER stress induced in pmm2it768 mutants was ameliorated by the treatment of the Nrf2-activator sulforaphane, indicating that Nrf2 plays significant roles in the reduction of ER stress.	sulforaphane	104-116	nfe2 like bZIP transcription factor 2a	Danio rerio	134-138
29530050-0	2018	Sulforaphane rescues amyloid-beta peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages.	sulforaphane	0-12	MER proto-oncogene, tyrosine kinase	Homo sapiens	63-68
29530050-11	2018	Such adverse effects of sulforaphane were replicated by BAY 11-7082, a NF-kappaB inhibitor.	sulforaphane	24-36	nuclear factor kappa B subunit 1	Homo sapiens	71-80
29530050-0	2018	Sulforaphane rescues amyloid-beta peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages.	sulforaphane	0-12	GLI family zinc finger 2	Homo sapiens	126-131
29530050-12	2018	Moreover, sulforaphane"s anti-inflammatory effects on Abeta1-42-induced production of IL-1beta and TNF-alpha were significantly diminished by siRNA-mediated knockdown of MerTK, confirming a critical role of MerTK in suppressing Abeta1-42-induced innate immune response.	sulforaphane	10-22	interleukin 1 beta	Homo sapiens	86-94
29530050-3	2018	METHODS: The objective of this study was to determine the underlying mechanism involved in Abeta-mediated decrease in MerTK expression through Abeta-mediated regulation of MerTK expression and its modulation by sulforaphane in human THP-1 macrophages challenged with Abeta1-42.	sulforaphane	211-223	amyloid beta precursor protein	Homo sapiens	91-96
29530050-12	2018	Moreover, sulforaphane"s anti-inflammatory effects on Abeta1-42-induced production of IL-1beta and TNF-alpha were significantly diminished by siRNA-mediated knockdown of MerTK, confirming a critical role of MerTK in suppressing Abeta1-42-induced innate immune response.	sulforaphane	10-22	tumor necrosis factor	Homo sapiens	99-108
29530050-3	2018	METHODS: The objective of this study was to determine the underlying mechanism involved in Abeta-mediated decrease in MerTK expression through Abeta-mediated regulation of MerTK expression and its modulation by sulforaphane in human THP-1 macrophages challenged with Abeta1-42.	sulforaphane	211-223	MER proto-oncogene, tyrosine kinase	Homo sapiens	118-123
29530050-12	2018	Moreover, sulforaphane"s anti-inflammatory effects on Abeta1-42-induced production of IL-1beta and TNF-alpha were significantly diminished by siRNA-mediated knockdown of MerTK, confirming a critical role of MerTK in suppressing Abeta1-42-induced innate immune response.	sulforaphane	10-22	MER proto-oncogene, tyrosine kinase	Homo sapiens	170-175
29530050-12	2018	Moreover, sulforaphane"s anti-inflammatory effects on Abeta1-42-induced production of IL-1beta and TNF-alpha were significantly diminished by siRNA-mediated knockdown of MerTK, confirming a critical role of MerTK in suppressing Abeta1-42-induced innate immune response.	sulforaphane	10-22	MER proto-oncogene, tyrosine kinase	Homo sapiens	207-212
29530050-3	2018	METHODS: The objective of this study was to determine the underlying mechanism involved in Abeta-mediated decrease in MerTK expression through Abeta-mediated regulation of MerTK expression and its modulation by sulforaphane in human THP-1 macrophages challenged with Abeta1-42.	sulforaphane	211-223	amyloid beta precursor protein	Homo sapiens	143-148
29530050-3	2018	METHODS: The objective of this study was to determine the underlying mechanism involved in Abeta-mediated decrease in MerTK expression through Abeta-mediated regulation of MerTK expression and its modulation by sulforaphane in human THP-1 macrophages challenged with Abeta1-42.	sulforaphane	211-223	GLI family zinc finger 2	Homo sapiens	233-238
29530050-13	2018	CONCLUSION: These findings implicate that targeting of MerTK with phytochemical sulforaphane as a mechanism for preventing Abeta1-42-induced neuroinflammation has potential to be applied in AD therapeutics.	sulforaphane	80-92	MER proto-oncogene, tyrosine kinase	Homo sapiens	55-60
29530050-10	2018	Notably, sulforaphane treatment potently inhibited Abeta1-42-induced intracellular Ca2+ level and rescued the decrease in MerTK expression by blocking nuclear factor-kappaB (NF-kappaB) nuclear translocation, thereby decreasing IL-1beta and TNF-alpha production upon Abeta1-42 stimulation.	sulforaphane	9-21	MER proto-oncogene, tyrosine kinase	Homo sapiens	122-127
29530050-10	2018	Notably, sulforaphane treatment potently inhibited Abeta1-42-induced intracellular Ca2+ level and rescued the decrease in MerTK expression by blocking nuclear factor-kappaB (NF-kappaB) nuclear translocation, thereby decreasing IL-1beta and TNF-alpha production upon Abeta1-42 stimulation.	sulforaphane	9-21	nuclear factor kappa B subunit 1	Homo sapiens	151-172
29530050-10	2018	Notably, sulforaphane treatment potently inhibited Abeta1-42-induced intracellular Ca2+ level and rescued the decrease in MerTK expression by blocking nuclear factor-kappaB (NF-kappaB) nuclear translocation, thereby decreasing IL-1beta and TNF-alpha production upon Abeta1-42 stimulation.	sulforaphane	9-21	nuclear factor kappa B subunit 1	Homo sapiens	174-183
29530050-10	2018	Notably, sulforaphane treatment potently inhibited Abeta1-42-induced intracellular Ca2+ level and rescued the decrease in MerTK expression by blocking nuclear factor-kappaB (NF-kappaB) nuclear translocation, thereby decreasing IL-1beta and TNF-alpha production upon Abeta1-42 stimulation.	sulforaphane	9-21	interleukin 1 beta	Homo sapiens	227-235
29530050-10	2018	Notably, sulforaphane treatment potently inhibited Abeta1-42-induced intracellular Ca2+ level and rescued the decrease in MerTK expression by blocking nuclear factor-kappaB (NF-kappaB) nuclear translocation, thereby decreasing IL-1beta and TNF-alpha production upon Abeta1-42 stimulation.	sulforaphane	9-21	tumor necrosis factor	Homo sapiens	240-249
29431641-4	2018	Western blot showed that the sustained phosphorylation of ERK1/2 mediated by SFN metabolites caused activation and upregulation of cleaved Caspase 3 and downregulation of alpha-tubulin.	sulforaphane	77-80	mitogen-activated protein kinase 3	Homo sapiens	58-64
29518137-8	2018	Additionally, SFN enhanced mitochondrial respiration in the hearts of DOX-treated rats and reduced cardiac oxidative stress caused by DOX, as evidenced by the inhibition of lipid peroxidation, the activation of NF-E2-related factor 2 (Nrf2) and associated antioxidant enzymes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	211-233
29518137-8	2018	Additionally, SFN enhanced mitochondrial respiration in the hearts of DOX-treated rats and reduced cardiac oxidative stress caused by DOX, as evidenced by the inhibition of lipid peroxidation, the activation of NF-E2-related factor 2 (Nrf2) and associated antioxidant enzymes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	235-239
29523849-6	2018	Furthermore, the antioxidant compound Sulforaphane downregulates p63-iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production.	sulforaphane	38-50	tumor protein p63	Homo sapiens	65-68
29523849-6	2018	Furthermore, the antioxidant compound Sulforaphane downregulates p63-iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production.	sulforaphane	38-50	rhomboid 5 homolog 2	Homo sapiens	69-75
29431641-4	2018	Western blot showed that the sustained phosphorylation of ERK1/2 mediated by SFN metabolites caused activation and upregulation of cleaved Caspase 3 and downregulation of alpha-tubulin.	sulforaphane	77-80	caspase 3	Homo sapiens	139-148
29431641-4	2018	Western blot showed that the sustained phosphorylation of ERK1/2 mediated by SFN metabolites caused activation and upregulation of cleaved Caspase 3 and downregulation of alpha-tubulin.	sulforaphane	77-80	tubulin alpha 1b	Homo sapiens	171-184
29431641-6	2018	Both co-immunoprecipitation and immunofluorescence staining implicated the interaction between SFN metabolite-induced phosphorylated ERK1/2 and alpha-tubulin, and Caspase 3 cleavage assay showed that alpha-tubulin might be the substrate for cleaved Caspase 3.	sulforaphane	95-98	mitogen-activated protein kinase 3	Homo sapiens	133-139
29431641-6	2018	Both co-immunoprecipitation and immunofluorescence staining implicated the interaction between SFN metabolite-induced phosphorylated ERK1/2 and alpha-tubulin, and Caspase 3 cleavage assay showed that alpha-tubulin might be the substrate for cleaved Caspase 3.	sulforaphane	95-98	tubulin alpha 1b	Homo sapiens	144-157
29431641-6	2018	Both co-immunoprecipitation and immunofluorescence staining implicated the interaction between SFN metabolite-induced phosphorylated ERK1/2 and alpha-tubulin, and Caspase 3 cleavage assay showed that alpha-tubulin might be the substrate for cleaved Caspase 3.	sulforaphane	95-98	tubulin alpha 1b	Homo sapiens	200-213
29431641-6	2018	Both co-immunoprecipitation and immunofluorescence staining implicated the interaction between SFN metabolite-induced phosphorylated ERK1/2 and alpha-tubulin, and Caspase 3 cleavage assay showed that alpha-tubulin might be the substrate for cleaved Caspase 3.	sulforaphane	95-98	caspase 3	Homo sapiens	249-258
29431641-7	2018	More, the SFN metabolite-mediated reduction of alpha-tubulin increased the depolymerization and instability of microtubules by microtubule polymerization assay.	sulforaphane	10-13	tubulin alpha 1b	Homo sapiens	47-60
29593120-0	2018	ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells.	sulforaphane	57-69	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	27-31
29565500-3	2018	MATERIALS AND METHODS: Wistar rats were randomly divided into control group, TLI group by crushing method, and Nrf2 activation group which received Nrf2 specific agonist sulforaphane 30 min before TLI treatment.	sulforaphane	170-182	NFE2 like bZIP transcription factor 2	Rattus norvegicus	148-152
29407470-0	2018	Anticarcinogenic activities of sulforaphane are influenced by Nerve Growth Factor in human melanoma A375 cells.	sulforaphane	31-43	nerve growth factor	Homo sapiens	62-81
29407470-4	2018	For the first time, our results show that a supplementation of Nerve Growth Factor partially reverses the sulforaphane-induced: i) inhibition of cell migration, ii) pro apoptotic changes in cell cycle and iii) modulation of active caspase-3.	sulforaphane	106-118	nerve growth factor	Homo sapiens	63-82
29407470-4	2018	For the first time, our results show that a supplementation of Nerve Growth Factor partially reverses the sulforaphane-induced: i) inhibition of cell migration, ii) pro apoptotic changes in cell cycle and iii) modulation of active caspase-3.	sulforaphane	106-118	caspase 3	Homo sapiens	231-240
29407470-5	2018	Furthermore, we report the sulforaphane-induced modulation in the expression of Nerve Growth Factor receptors TrKA and p75NTR, shifting their ratio from pro survival to pro apoptotic.	sulforaphane	27-39	nerve growth factor	Homo sapiens	80-99
29407470-5	2018	Furthermore, we report the sulforaphane-induced modulation in the expression of Nerve Growth Factor receptors TrKA and p75NTR, shifting their ratio from pro survival to pro apoptotic.	sulforaphane	27-39	neurotrophic receptor tyrosine kinase 1	Homo sapiens	110-114
29407470-5	2018	Furthermore, we report the sulforaphane-induced modulation in the expression of Nerve Growth Factor receptors TrKA and p75NTR, shifting their ratio from pro survival to pro apoptotic.	sulforaphane	27-39	nerve growth factor receptor	Homo sapiens	119-125
29407470-6	2018	In conclusion, the present study evidences that in vivo the antineoplastic effects of sulforaphane may be reduced by the contemporaneous presence of other biological elements such as Nerve Growth Factor and it contributes to a better definition of the real in vivo potentiality of sulforaphane as antineoplastic candidate.	sulforaphane	86-98	nerve growth factor	Homo sapiens	183-202
29593120-2	2018	Our results demonstrated that sulforaphane inhibited proliferation of AGS cells by promoting apoptosis and accumulating the cellular portion of the G2/M phase via the buildup of cyclin B1 and cyclin-dependent kinase p21 (WAF1/CIP1).	sulforaphane	30-42	cyclin B1	Homo sapiens	178-187
29593120-2	2018	Our results demonstrated that sulforaphane inhibited proliferation of AGS cells by promoting apoptosis and accumulating the cellular portion of the G2/M phase via the buildup of cyclin B1 and cyclin-dependent kinase p21 (WAF1/CIP1).	sulforaphane	30-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	216-219
29593120-2	2018	Our results demonstrated that sulforaphane inhibited proliferation of AGS cells by promoting apoptosis and accumulating the cellular portion of the G2/M phase via the buildup of cyclin B1 and cyclin-dependent kinase p21 (WAF1/CIP1).	sulforaphane	30-42	cyclin dependent kinase inhibitor 1A	Homo sapiens	221-230
29593120-4	2018	Sulforaphane concurrently induced phosphorylation of AMPK; however, compound C, an AMPK inhibitor, significantly blocked sulforaphane-induced apoptosis, suggesting that sulforaphane induces apoptosis of AGS cells through the AMPK-dependent pathway.	sulforaphane	0-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	53-57
29593120-5	2018	Sulforaphane also activated the mitochondrial apoptotic signaling pathway with a decrease in mitochondrial membrane potential and the nuclear translocation of cytochrome c.	sulforaphane	0-12	cytochrome c, somatic	Homo sapiens	159-171
29593120-6	2018	Furthermore, sulforaphane provoked the generation of intracellular ROS; especially when ROS production was blocked by antioxidant N-acetylcysteine, both AMPK activation and growth inhibition by sulforaphane were completely abolished.	sulforaphane	13-25	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	153-157
29593120-6	2018	Furthermore, sulforaphane provoked the generation of intracellular ROS; especially when ROS production was blocked by antioxidant N-acetylcysteine, both AMPK activation and growth inhibition by sulforaphane were completely abolished.	sulforaphane	194-206	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	153-157
29593120-7	2018	Collectively, these findings suggest that sulforaphane inhibited growth of AGS cells, which was mediated by a complex interplay between cellular mechanisms governing redox homeostasis, apoptosis, and cell cycle arrest through an ROS/AMPK-dependent pathway.	sulforaphane	42-54	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	233-237
29380937-8	2018	SFN significantly decreases the expressions of acetyl CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase.	sulforaphane	0-3	acetyl-CoA carboxylase alpha	Homo sapiens	73-77
29205354-7	2018	These pathological effects were enhanced in Nrf2-deficient mice, whereas Nrf2 activation with sulphoraphane protected podocytes against Hb toxicity both in vivo and in vitro.	sulforaphane	94-107	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
29380937-0	2018	Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.	sulforaphane	0-12	X-box binding protein 1	Homo sapiens	71-75
29380937-8	2018	SFN significantly decreases the expressions of acetyl CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase.	sulforaphane	0-3	stearoyl-CoA desaturase	Homo sapiens	80-105
29380937-0	2018	Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways.	sulforaphane	0-12	stearoyl-CoA desaturase	Homo sapiens	85-89
29380937-8	2018	SFN significantly decreases the expressions of acetyl CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase.	sulforaphane	0-3	stearoyl-CoA desaturase	Homo sapiens	107-111
29380937-8	2018	SFN significantly decreases the expressions of acetyl CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase.	sulforaphane	0-3	acetyl-CoA carboxylase alpha	Homo sapiens	47-71
29380937-9	2018	SFN inhibits SREBP1c by blocking the PERK.	sulforaphane	0-3	sterol regulatory element binding transcription factor 1	Homo sapiens	13-20
29380937-9	2018	SFN inhibits SREBP1c by blocking the PERK.	sulforaphane	0-3	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	37-41
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	sulforaphane	269-281	DEPP1 autophagy regulator	Homo sapiens	78-82
29618945-5	2018	We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.	sulforaphane	215-227	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
29305271-0	2018	Sulforaphane and 5-fluorouracil synergistically inducing autophagy in breast cancer: A possible role for the Nrf2-Keap1-ARE signaling?	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
29305271-0	2018	Sulforaphane and 5-fluorouracil synergistically inducing autophagy in breast cancer: A possible role for the Nrf2-Keap1-ARE signaling?	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	114-119
29316264-11	2018	Reversely, sulforaphane, a Nrf2 activator, increased the number of iPSCs colonies.	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
29391571-2	2018	Here we demonstrated that dietary intake of glucoraphanin (GF), the precursor of a natural antioxidant sulforaphane, during juvenile and adolescent stages prevented cognitive deficits and loss of parvalbumin (PV) immunoreactivity in the medial prefrontal cortex (mPFC) of adult offspring after MIA.	sulforaphane	103-115	parvalbumin	Homo sapiens	196-207
29307179-2	2018	Among Nrf2 activators, isothiocyanate sulforaphane (SFN), derived from precursor glucosinolate present in Brassica vegetables, has gained attention as a potential neuroprotective compound.	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	6-10
29362432-6	2018	Meanwhile, rat type II alveolar epithelial cells line (RLE-6TN) and human epithelial cells line (A549) were both treated with an Nrf2 activator sulforaphane (SFN), or transfected siRNAs of Nrf2 and Numb to unravel roles of Nrf2 pathway, Numb and the link between them on transforming growth factor beta1 (TGF-beta1)-induced EMT.	sulforaphane	158-161	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
29410668-0	2018	Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression and Switches to Mox Phenotype through Activating Extracellular Signal-Regulated Kinase 1/2-Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway in Murine Microglial Cells.	sulforaphane	0-12	microRNA 155	Mus musculus	99-106
29410668-0	2018	Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression and Switches to Mox Phenotype through Activating Extracellular Signal-Regulated Kinase 1/2-Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway in Murine Microglial Cells.	sulforaphane	0-12	mitogen-activated protein kinase 3	Mus musculus	167-208
29410668-0	2018	Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression and Switches to Mox Phenotype through Activating Extracellular Signal-Regulated Kinase 1/2-Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway in Murine Microglial Cells.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	209-252
29410668-5	2018	SFN induced translocation of Nrf2 to the nucleus via extracellular signal-regulated kinase 1/2 (ERK1/2) pathway activation.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
29410668-5	2018	SFN induced translocation of Nrf2 to the nucleus via extracellular signal-regulated kinase 1/2 (ERK1/2) pathway activation.	sulforaphane	0-3	mitogen-activated protein kinase 3	Mus musculus	53-94
29410668-5	2018	SFN induced translocation of Nrf2 to the nucleus via extracellular signal-regulated kinase 1/2 (ERK1/2) pathway activation.	sulforaphane	0-3	mitogen-activated protein kinase 3	Mus musculus	96-102
29410668-6	2018	siRNA-mediated knockdown study showed that the effects of SFN on LPS-induced reactive oxygen species, reactive nitrogen species, and pro-inflammatory cytokine production and cell death are partly Nrf2 dependent.	sulforaphane	58-61	nuclear factor, erythroid derived 2, like 2	Mus musculus	196-200
29410668-8	2018	Our results suggested that SFN induced the Mox phenotype in murine microglia through Nrf2 pathway.	sulforaphane	27-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
29410668-9	2018	SFN also alleviated LPS-induced expression of inflammatory microRNA, miR-155.	sulforaphane	0-3	microRNA 155	Mus musculus	69-76
28923347-12	2018	In mice on HFHSD, SFN improved glucose tolerance, MAM protein content and ER-mitochondria interactions to a similar extent to that of metformin.	sulforaphane	18-21	activating transcription factor 7 interacting protein	Mus musculus	50-53
29069573-0	2018	Sulforaphane restores acetyl-histone H3 binding to Bcl-2 promoter and prevents apoptosis in ethanol-exposed neural crest cells and mouse embryos.	sulforaphane	0-12	B cell leukemia/lymphoma 2	Mus musculus	51-56
29069573-8	2018	ChIP-qPCR assay revealed that ethanol exposure significantly decreased acetyl-histone H3 binding to the Bcl-2 promoter while supplementing with SFN reversed the ethanol-induced reduction in acetyl-histone H3 binding to the Bcl-2 promoter.	sulforaphane	144-147	B cell leukemia/lymphoma 2	Mus musculus	223-228
29069573-9	2018	In addition, SFN treatment restored the expression of Bcl-2 in ethanol-exposed NCCs and diminished ethanol-induced apoptosis in NCCs.	sulforaphane	13-16	B cell leukemia/lymphoma 2	Mus musculus	54-59
29069573-11	2018	These results demonstrate that SFN can epigenetically restore the expression of Bcl-2 and attenuate ethanol-induced apoptosis by increasing histone acetylation at the Bcl-2 promoter and suggest that SFN may prevent FASD through epigenetic regulation of the expression of anti-apoptotic genes.	sulforaphane	31-34	B cell leukemia/lymphoma 2	Mus musculus	80-85
29069573-11	2018	These results demonstrate that SFN can epigenetically restore the expression of Bcl-2 and attenuate ethanol-induced apoptosis by increasing histone acetylation at the Bcl-2 promoter and suggest that SFN may prevent FASD through epigenetic regulation of the expression of anti-apoptotic genes.	sulforaphane	31-34	B cell leukemia/lymphoma 2	Mus musculus	167-172
29069573-11	2018	These results demonstrate that SFN can epigenetically restore the expression of Bcl-2 and attenuate ethanol-induced apoptosis by increasing histone acetylation at the Bcl-2 promoter and suggest that SFN may prevent FASD through epigenetic regulation of the expression of anti-apoptotic genes.	sulforaphane	199-202	B cell leukemia/lymphoma 2	Mus musculus	80-85
29069573-11	2018	These results demonstrate that SFN can epigenetically restore the expression of Bcl-2 and attenuate ethanol-induced apoptosis by increasing histone acetylation at the Bcl-2 promoter and suggest that SFN may prevent FASD through epigenetic regulation of the expression of anti-apoptotic genes.	sulforaphane	199-202	B cell leukemia/lymphoma 2	Mus musculus	167-172
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	sulforaphane	269-281	zinc fingers and homeoboxes 2	Homo sapiens	150-153
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	sulforaphane	269-281	mitogen-activated protein kinase kinase 7	Homo sapiens	154-157
29440765-8	2018	In addition to baicalin treatment, we found that the hypoxia-response protein DEPP functions as a positive regulator involving the regulations of Ras/Raf/MEK/ERK signaling pathway and inhibition of human colon cancer by other anti-oxidative drugs, such as curcumin and sulforaphane, resulting in tumor cellular senescence.	sulforaphane	269-281	mitogen-activated protein kinase 1	Homo sapiens	158-161
29898626-5	2018	A recent study demonstrated that glucoraphanin, a precursor of the Nrf2 activator sulforaphane, ameliorates obesity by enhancing energy expenditure and browning of white adipose tissue, and attenuates obesity-related inflammation and insulin resistance by polarizing M2 macrophages and reducing metabolic endotoxemia.	sulforaphane	82-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
29241671-4	2018	Induction of detoxifying enzymes by the Nrf2 activator butylated hydroxyanisole (BHA) or sulforaphane, was attenuated in the liver and small intestines of Mkp-1-/- mice, indicating that the Nrf2 signaling pathway is impaired as a result of Mkp-1 deficiency.	sulforaphane	89-101	dual specificity phosphatase 1	Mus musculus	155-160
29154837-4	2018	In at least in vitro experiments, TPNA10168, identified from the library, showed a higher efficacy in Nrf2 activation and a lower cytotoxicity than sulforaphane, a well-known Nrf2 activator.	sulforaphane	148-160	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179
29950142-6	2018	Oxidant challenge with paraquat or hydrogen peroxide, or pharmacological activation of NFE2L2 with sulforaphane or dimethyl fumarate also increased LAMP2A levels and CMA activity.	sulforaphane	99-111	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-93
29950142-6	2018	Oxidant challenge with paraquat or hydrogen peroxide, or pharmacological activation of NFE2L2 with sulforaphane or dimethyl fumarate also increased LAMP2A levels and CMA activity.	sulforaphane	99-111	lysosomal-associated membrane protein 2	Mus musculus	148-154
30355942-0	2018	Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
30458452-1	2018	BACKGROUND/AIMS: Sulforaphane-N-acetyl-cysteine (SFN-NAC) is a sulforaphane (SFN) metabolite with a longer half-life and better blood-brain barrier permeability than those of SFN.	sulforaphane	63-75	synuclein alpha	Homo sapiens	53-56
30458452-1	2018	BACKGROUND/AIMS: Sulforaphane-N-acetyl-cysteine (SFN-NAC) is a sulforaphane (SFN) metabolite with a longer half-life and better blood-brain barrier permeability than those of SFN.	sulforaphane	49-52	synuclein alpha	Homo sapiens	53-56
29466800-11	2018	RESULTS: The sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation, as demonstrated by immunohistochemical and Western blot analyses, delayed the progression of serum creatinine and blood urea nitrogen, particularly lowering the 24-hour urinary protein levels of CRAD.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
30458452-1	2018	BACKGROUND/AIMS: Sulforaphane-N-acetyl-cysteine (SFN-NAC) is a sulforaphane (SFN) metabolite with a longer half-life and better blood-brain barrier permeability than those of SFN.	sulforaphane	77-80	synuclein alpha	Homo sapiens	53-56
29376497-10	2018	RESULTS: L-Sulforaphane induced a dose-dependent increase in cell proliferation in the presence of hydrogen peroxide by upregulating Glutathione-S-Transferase mu1 gene expression.	sulforaphane	9-23	glutathione S-transferase mu 1	Homo sapiens	133-162
30041241-0	2018	Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-67
30041241-0	2018	Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells.	sulforaphane	0-12	prostaglandin E synthase	Homo sapiens	72-109
30041241-10	2018	An apoptotic effect of SFN was preceded by the activation of caspase-3 as well as accumulation of cells in the sub-G1 phase of the cell cycle.	sulforaphane	23-26	caspase 3	Homo sapiens	61-70
28176652-0	2018	Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation.	sulforaphane	55-67	microRNA 21	Homo sapiens	101-112
28176652-0	2018	Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation.	sulforaphane	55-67	telomerase reverse transcriptase	Homo sapiens	123-155
28176652-0	2018	Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation.	sulforaphane	55-67	telomerase reverse transcriptase	Homo sapiens	157-162
28176652-9	2018	CONCLUSION: Our studies suggest that the regulation of HDAC, hTERT and miR-21 is a promising approach for delaying and/or preventing CRC and may be accomplished via the consumption of SFN in cruciferous vegetables.	sulforaphane	184-187	histone deacetylase 9	Homo sapiens	55-59
28176652-9	2018	CONCLUSION: Our studies suggest that the regulation of HDAC, hTERT and miR-21 is a promising approach for delaying and/or preventing CRC and may be accomplished via the consumption of SFN in cruciferous vegetables.	sulforaphane	184-187	telomerase reverse transcriptase	Homo sapiens	61-66
28176652-9	2018	CONCLUSION: Our studies suggest that the regulation of HDAC, hTERT and miR-21 is a promising approach for delaying and/or preventing CRC and may be accomplished via the consumption of SFN in cruciferous vegetables.	sulforaphane	184-187	microRNA 21	Homo sapiens	71-77
29466800-0	2018	The Association Between Oxidative Stress Alleviation via Sulforaphane-Induced Nrf2-HO-1/NQO-1 Signaling Pathway Activation and Chronic Renal Allograft Dysfunction Improvement.	sulforaphane	57-69	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
29466800-0	2018	The Association Between Oxidative Stress Alleviation via Sulforaphane-Induced Nrf2-HO-1/NQO-1 Signaling Pathway Activation and Chronic Renal Allograft Dysfunction Improvement.	sulforaphane	57-69	heme oxygenase 1	Rattus norvegicus	83-87
29466800-0	2018	The Association Between Oxidative Stress Alleviation via Sulforaphane-Induced Nrf2-HO-1/NQO-1 Signaling Pathway Activation and Chronic Renal Allograft Dysfunction Improvement.	sulforaphane	57-69	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	88-93
29466800-4	2018	The present paper investigates whether there is an association between oxidative stress alleviation via sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation and CRAD improvement.	sulforaphane	104-116	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
29466800-4	2018	The present paper investigates whether there is an association between oxidative stress alleviation via sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation and CRAD improvement.	sulforaphane	104-116	heme oxygenase 1	Rattus norvegicus	130-134
29466800-4	2018	The present paper investigates whether there is an association between oxidative stress alleviation via sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation and CRAD improvement.	sulforaphane	104-116	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	135-140
29466800-11	2018	RESULTS: The sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation, as demonstrated by immunohistochemical and Western blot analyses, delayed the progression of serum creatinine and blood urea nitrogen, particularly lowering the 24-hour urinary protein levels of CRAD.	sulforaphane	13-25	heme oxygenase 1	Rattus norvegicus	39-43
29466800-11	2018	RESULTS: The sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation, as demonstrated by immunohistochemical and Western blot analyses, delayed the progression of serum creatinine and blood urea nitrogen, particularly lowering the 24-hour urinary protein levels of CRAD.	sulforaphane	13-25	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	44-49
29466800-14	2018	CONCLUSION: Oxidative stress alleviation caused by continuous sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation is associated with functional and morphological improvements of CRAD.	sulforaphane	62-74	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
29466800-14	2018	CONCLUSION: Oxidative stress alleviation caused by continuous sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation is associated with functional and morphological improvements of CRAD.	sulforaphane	62-74	heme oxygenase 1	Rattus norvegicus	88-92
29466800-14	2018	CONCLUSION: Oxidative stress alleviation caused by continuous sulforaphane-induced Nrf2-HO-1/NQO-1 signaling pathway activation is associated with functional and morphological improvements of CRAD.	sulforaphane	62-74	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	93-98
29634384-0	2018	Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation.	sulforaphane	78-90	cyclin dependent kinase inhibitor 2A	Homo sapiens	124-130
29634384-4	2018	In the present study, using methylation-sensitive restriction analysis (MSRA) and qPCR, we showed that clofarabine in combination with sulforaphane, a phytochemical from cruciferous vegetables, significantly reactivates DNA methylation-silenced CDKN2A tumour suppressor and inhibits cancer cell growth at a non-invasive breast cancer stage.	sulforaphane	135-147	cyclin dependent kinase inhibitor 2A	Homo sapiens	245-251
28147711-0	2017	Pharmacokinetics and in vitro and in vivo delivery of sulforaphane by PCL-PEG-PCL copolymeric-based micelles.	sulforaphane	54-66	PHD finger protein 1	Homo sapiens	70-73
29285189-0	2018	Sulforaphane reverses gefitinib tolerance in human lung cancer cells via modulation of sonic hedgehog signaling.	sulforaphane	0-12	sonic hedgehog signaling molecule	Homo sapiens	87-101
29285189-7	2018	SFN markedly inhibited the proliferation of PC9GT and PC9 cells in a dose-dependent manner; combination SFN/gefitinib treatment also markedly decreased PC9GT cell proliferation, compared with SFN or gefitinib administered alone (P<0.05).	sulforaphane	0-3	proprotein convertase subtilisin/kexin type 9	Homo sapiens	44-49
29285189-7	2018	SFN markedly inhibited the proliferation of PC9GT and PC9 cells in a dose-dependent manner; combination SFN/gefitinib treatment also markedly decreased PC9GT cell proliferation, compared with SFN or gefitinib administered alone (P<0.05).	sulforaphane	0-3	proprotein convertase subtilisin/kexin type 9	Homo sapiens	44-47
29285189-7	2018	SFN markedly inhibited the proliferation of PC9GT and PC9 cells in a dose-dependent manner; combination SFN/gefitinib treatment also markedly decreased PC9GT cell proliferation, compared with SFN or gefitinib administered alone (P<0.05).	sulforaphane	0-3	proprotein convertase subtilisin/kexin type 9	Homo sapiens	54-57
29285189-7	2018	SFN markedly inhibited the proliferation of PC9GT and PC9 cells in a dose-dependent manner; combination SFN/gefitinib treatment also markedly decreased PC9GT cell proliferation, compared with SFN or gefitinib administered alone (P<0.05).	sulforaphane	104-107	proprotein convertase subtilisin/kexin type 9	Homo sapiens	44-49
29285189-7	2018	SFN markedly inhibited the proliferation of PC9GT and PC9 cells in a dose-dependent manner; combination SFN/gefitinib treatment also markedly decreased PC9GT cell proliferation, compared with SFN or gefitinib administered alone (P<0.05).	sulforaphane	104-107	proprotein convertase subtilisin/kexin type 9	Homo sapiens	44-47
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	sonic hedgehog signaling molecule	Homo sapiens	54-57
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	smoothened, frizzled class receptor	Homo sapiens	59-62
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	GLI family zinc finger 1	Homo sapiens	67-71
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	proprotein convertase subtilisin/kexin type 9	Homo sapiens	75-78
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	proprotein convertase subtilisin/kexin type 9	Homo sapiens	85-88
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	13-16	proprotein convertase subtilisin/kexin type 9	Homo sapiens	85-88
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	127-130	sonic hedgehog signaling molecule	Homo sapiens	192-195
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	127-130	smoothened, frizzled class receptor	Homo sapiens	197-200
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	127-130	GLI family zinc finger 1	Homo sapiens	202-206
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	127-130	prominin 1	Homo sapiens	208-213
29285189-9	2018	Furthermore, SFN markedly inhibited the expression of SHH, SMO and GLI1 in PC9GT and PC9 cells in a dose dependent manner, and SFN combined with gefitinib markedly inhibited the expression of SHH, SMO, GLI1, CD133 and CD44 in PC9GT cells when compared with SFN or gefitinib monotherapy.	sulforaphane	127-130	CD44 molecule (Indian blood group)	Homo sapiens	218-222
29285189-10	2018	The results of the present study demonstrated that SFN inhibits the proliferation of gefitinib-tolerant lung cancer cells via modulation of the SHH signaling pathway.	sulforaphane	51-54	sonic hedgehog signaling molecule	Homo sapiens	144-147
29111554-7	2017	This is the first study to demonstrate that SFN could protect MLE-12 cells against PM2.5-induced oxidative damage via activation of the Nrf2 pathway and inhibition of the mitochondrial apoptotic pathway; therefore, SFN may be a promising compound for preventing PM2.5-triggered pulmonary cell damage.	sulforaphane	44-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
28147711-0	2017	Pharmacokinetics and in vitro and in vivo delivery of sulforaphane by PCL-PEG-PCL copolymeric-based micelles.	sulforaphane	54-66	PHD finger protein 1	Homo sapiens	78-81
28147711-1	2017	A reliable and efficient drug delivery system using PCL-PEG-PCL copolymers was established for the anti-cancer compound sulforaphane (SF) in this study.	sulforaphane	120-132	PHD finger protein 1	Homo sapiens	52-55
28147711-1	2017	A reliable and efficient drug delivery system using PCL-PEG-PCL copolymers was established for the anti-cancer compound sulforaphane (SF) in this study.	sulforaphane	120-132	PHD finger protein 1	Homo sapiens	60-63
28147711-1	2017	A reliable and efficient drug delivery system using PCL-PEG-PCL copolymers was established for the anti-cancer compound sulforaphane (SF) in this study.	sulforaphane	134-136	PHD finger protein 1	Homo sapiens	52-55
28147711-1	2017	A reliable and efficient drug delivery system using PCL-PEG-PCL copolymers was established for the anti-cancer compound sulforaphane (SF) in this study.	sulforaphane	134-136	PHD finger protein 1	Homo sapiens	60-63
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	13-15	PHD finger protein 1	Homo sapiens	19-22
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	13-15	PHD finger protein 1	Homo sapiens	27-30
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	13-15	PHD finger protein 1	Homo sapiens	27-30
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	13-15	PHD finger protein 1	Homo sapiens	27-30
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	65-67	PHD finger protein 1	Homo sapiens	19-22
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	65-67	PHD finger protein 1	Homo sapiens	27-30
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	65-67	PHD finger protein 1	Homo sapiens	27-30
28147711-2	2017	Encapsulated SF by PCL-PEG-PCL nanoparticles led to formation of SF-loaded PCL-PEG-PCL micelles.	sulforaphane	65-67	PHD finger protein 1	Homo sapiens	27-30
28888052-2	2017	The effect of alcohol on TGFbeta1 is mitigated by treatment with sulforaphane (SFP), which can activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	65-77	transforming growth factor, beta 1	Mus musculus	25-33
28937835-7	2017	RESULTS: Compared with the saline group, the SFN-treated group showed significantly higher ERG a-wave and b-wave amplitudes, less photoreceptor death, and the downregulation of GRP78/BiP.	sulforaphane	45-48	heat shock protein 5	Mus musculus	177-182
28937835-7	2017	RESULTS: Compared with the saline group, the SFN-treated group showed significantly higher ERG a-wave and b-wave amplitudes, less photoreceptor death, and the downregulation of GRP78/BiP.	sulforaphane	45-48	heat shock protein 5	Mus musculus	183-186
28937835-8	2017	CONCLUSIONS: Our data showed that SFN ameliorated the retinal degeneration of rd10 mice, which is possibly related to the downregulation of GRP78 expression.	sulforaphane	34-37	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	78-82
28937835-8	2017	CONCLUSIONS: Our data showed that SFN ameliorated the retinal degeneration of rd10 mice, which is possibly related to the downregulation of GRP78 expression.	sulforaphane	34-37	heat shock protein 5	Mus musculus	140-145
29043603-7	2017	Organosulfur rich compounds such as the sulforaphane found in broccoli appear to normalize DNA methylation and activate miR-140 expression, which represses SOX9 and ALDH1 and decreases tumor growth.	sulforaphane	40-52	microRNA 140	Homo sapiens	120-127
29043603-7	2017	Organosulfur rich compounds such as the sulforaphane found in broccoli appear to normalize DNA methylation and activate miR-140 expression, which represses SOX9 and ALDH1 and decreases tumor growth.	sulforaphane	40-52	SRY-box transcription factor 9	Homo sapiens	156-160
29043603-7	2017	Organosulfur rich compounds such as the sulforaphane found in broccoli appear to normalize DNA methylation and activate miR-140 expression, which represses SOX9 and ALDH1 and decreases tumor growth.	sulforaphane	40-52	aldehyde dehydrogenase 1 family member A1	Homo sapiens	165-170
28946211-0	2017	Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt/Foxo1 axis in C2C12 myotubes.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	81-84
28946211-0	2017	Sulforaphane prevents dexamethasone-induced muscle atrophy via regulation of the Akt/Foxo1 axis in C2C12 myotubes.	sulforaphane	0-12	forkhead box O1	Homo sapiens	85-90
28946211-9	2017	These results show SFN inhibits DEX-induced muscle atrophy in C2C12 myotubes via Akt/Foxo signaling.	sulforaphane	19-22	AKT serine/threonine kinase 1	Homo sapiens	81-84
28888052-2	2017	The effect of alcohol on TGFbeta1 is mitigated by treatment with sulforaphane (SFP), which can activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	65-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-147
28888052-2	2017	The effect of alcohol on TGFbeta1 is mitigated by treatment with sulforaphane (SFP), which can activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	65-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
29074861-0	2017	Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
28944886-0	2017	Sulforaphane induces p53-deficient SW480 cell apoptosis via the ROS-MAPK signaling pathway.	sulforaphane	0-12	tumor protein p53	Homo sapiens	21-24
28944886-0	2017	Sulforaphane induces p53-deficient SW480 cell apoptosis via the ROS-MAPK signaling pathway.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	68-72
28944886-2	2017	However, the detailed anticancer effects of SFN on p53-deficient colon cancer cells has yet to be clearly elucidated.	sulforaphane	44-47	tumor protein p53	Homo sapiens	51-54
28944886-4	2017	The critical events leading to apoptosis were then evaluated in SFN-treated p53-deficient SW480 cells, by performing an MTT assay, flow cytometry, western blotting and ELISA.	sulforaphane	64-67	tumor protein p53	Homo sapiens	76-79
28944886-6	2017	In addition, SFN-induced apoptosis was associated with an increase in the generation of reactive oxygen species (ROS), and the activation of extracellular signal-regulated kinases (Erk) and p38 mitogen-activated protein kinases.	sulforaphane	13-16	mitogen-activated protein kinase 1	Homo sapiens	141-179
28944886-6	2017	In addition, SFN-induced apoptosis was associated with an increase in the generation of reactive oxygen species (ROS), and the activation of extracellular signal-regulated kinases (Erk) and p38 mitogen-activated protein kinases.	sulforaphane	13-16	mitogen-activated protein kinase 1	Homo sapiens	181-184
28944886-6	2017	In addition, SFN-induced apoptosis was associated with an increase in the generation of reactive oxygen species (ROS), and the activation of extracellular signal-regulated kinases (Erk) and p38 mitogen-activated protein kinases.	sulforaphane	13-16	mitogen-activated protein kinase 1	Homo sapiens	190-193
28944886-8	2017	SFN-induced apoptosis was subsequently confirmed to be ROS-dependent and associated with Erk/p38, as the specific inhibitors for ROS, phosphorylated (p)-Erk and p-p38, completely or partially attenuated the SFN-induced reduction in SW480 cell viability.	sulforaphane	0-3	mitogen-activated protein kinase 1	Homo sapiens	89-92
28944886-8	2017	SFN-induced apoptosis was subsequently confirmed to be ROS-dependent and associated with Erk/p38, as the specific inhibitors for ROS, phosphorylated (p)-Erk and p-p38, completely or partially attenuated the SFN-induced reduction in SW480 cell viability.	sulforaphane	0-3	mitogen-activated protein kinase 1	Homo sapiens	93-96
28944886-8	2017	SFN-induced apoptosis was subsequently confirmed to be ROS-dependent and associated with Erk/p38, as the specific inhibitors for ROS, phosphorylated (p)-Erk and p-p38, completely or partially attenuated the SFN-induced reduction in SW480 cell viability.	sulforaphane	0-3	mitogen-activated protein kinase 1	Homo sapiens	153-156
28944886-8	2017	SFN-induced apoptosis was subsequently confirmed to be ROS-dependent and associated with Erk/p38, as the specific inhibitors for ROS, phosphorylated (p)-Erk and p-p38, completely or partially attenuated the SFN-induced reduction in SW480 cell viability.	sulforaphane	0-3	mitogen-activated protein kinase 1	Homo sapiens	163-166
28944886-8	2017	SFN-induced apoptosis was subsequently confirmed to be ROS-dependent and associated with Erk/p38, as the specific inhibitors for ROS, phosphorylated (p)-Erk and p-p38, completely or partially attenuated the SFN-induced reduction in SW480 cell viability.	sulforaphane	207-210	mitogen-activated protein kinase 1	Homo sapiens	89-92
28944886-10	2017	In conclusion, the results suggest that SFN may induce apoptosis in p53-deficient SW480 cells via p53/p73-independent and ROS-Erk/p38-dependent signaling pathways.	sulforaphane	40-43	tumor protein p53	Homo sapiens	68-71
28944886-10	2017	In conclusion, the results suggest that SFN may induce apoptosis in p53-deficient SW480 cells via p53/p73-independent and ROS-Erk/p38-dependent signaling pathways.	sulforaphane	40-43	tumor protein p53	Homo sapiens	98-101
28944886-10	2017	In conclusion, the results suggest that SFN may induce apoptosis in p53-deficient SW480 cells via p53/p73-independent and ROS-Erk/p38-dependent signaling pathways.	sulforaphane	40-43	tumor protein p73	Homo sapiens	102-105
28944886-10	2017	In conclusion, the results suggest that SFN may induce apoptosis in p53-deficient SW480 cells via p53/p73-independent and ROS-Erk/p38-dependent signaling pathways.	sulforaphane	40-43	mitogen-activated protein kinase 1	Homo sapiens	126-129
28944886-10	2017	In conclusion, the results suggest that SFN may induce apoptosis in p53-deficient SW480 cells via p53/p73-independent and ROS-Erk/p38-dependent signaling pathways.	sulforaphane	40-43	mitogen-activated protein kinase 1	Homo sapiens	130-133
29242678-1	2017	Targeting the NRF2 Pathway with Sulforaphane.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
29242678-4	2017	Many putative cellular targets are affected by sulforaphane although only one, KEAP1-NRF2 signaling, can be considered a validated target at this time.	sulforaphane	47-59	kelch like ECH associated protein 1	Homo sapiens	79-84
29242678-4	2017	Many putative cellular targets are affected by sulforaphane although only one, KEAP1-NRF2 signaling, can be considered a validated target at this time.	sulforaphane	47-59	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
29242678-6	2017	Scope and Approach: This review summarizes the chemical biology of sulforaphane as an inducer of NRF2 signaling and efficacy as an inhibitor of carcinogenesis.	sulforaphane	67-79	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
29242678-9	2017	In many of these settings the antitumorigenic efficacy of sulforaphane is dampened in Nrf2-disrupted animals.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
28278681-3	2017	In HepG2, Caco-2 and Vero cells, we investigated the sulforaphane (SFN) (5 muM) role in counteracting redox imbalance induced by VOSO4 [V(IV)].	sulforaphane	53-65	latexin	Homo sapiens	75-78
28278681-3	2017	In HepG2, Caco-2 and Vero cells, we investigated the sulforaphane (SFN) (5 muM) role in counteracting redox imbalance induced by VOSO4 [V(IV)].	sulforaphane	67-70	latexin	Homo sapiens	75-78
29072615-7	2017	Additionally, pharmacological inhibition of p-STAT3 by sulforaphane downregulated MDR1 and MRP1, resulting in A549/T cell death by triggering apoptosis.	sulforaphane	55-67	signal transducer and activator of transcription 3	Homo sapiens	46-51
29072615-7	2017	Additionally, pharmacological inhibition of p-STAT3 by sulforaphane downregulated MDR1 and MRP1, resulting in A549/T cell death by triggering apoptosis.	sulforaphane	55-67	ATP binding cassette subfamily B member 1	Homo sapiens	82-86
29072615-7	2017	Additionally, pharmacological inhibition of p-STAT3 by sulforaphane downregulated MDR1 and MRP1, resulting in A549/T cell death by triggering apoptosis.	sulforaphane	55-67	ATP binding cassette subfamily C member 1	Homo sapiens	91-95
29074861-0	2017	Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress.	sulforaphane	0-12	peroxiredoxin 6	Homo sapiens	75-80
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	18-30	NFE2 like bZIP transcription factor 2	Homo sapiens	2-6
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	18-30	peroxiredoxin 6	Homo sapiens	48-53
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	18-30	catalase	Homo sapiens	55-63
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	18-30	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	32-35	NFE2 like bZIP transcription factor 2	Homo sapiens	2-6
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	32-35	peroxiredoxin 6	Homo sapiens	48-53
29074861-5	2017	A Nrf2 activator, Sulforaphane (SFN), augmented Prdx6, catalase and GSTpi expression in dose-dependent fashion, and halted Nrf2 dysregulation of these antioxidants.	sulforaphane	32-35	catalase	Homo sapiens	55-63
29074861-7	2017	Conversely, promoter mutated at ARE site did not respond to SFN, validating the SFN-mediated restoration of Nrf2/ARE signaling.	sulforaphane	80-83	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
29074861-8	2017	Furthermore, SFN rescued cells from UVB-induced toxicity in dose-dependent fashion, which was consistent with SFN"s dose-dependent activation of Nrf2/ARE interaction.	sulforaphane	13-16	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
29074861-8	2017	Furthermore, SFN rescued cells from UVB-induced toxicity in dose-dependent fashion, which was consistent with SFN"s dose-dependent activation of Nrf2/ARE interaction.	sulforaphane	110-113	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
29074861-9	2017	Importantly, knockdown of Prdx6 revealed that Prdx6 expression was prerequisite for SFN-mediated cytoprotection.	sulforaphane	84-87	peroxiredoxin 6	Homo sapiens	26-31
29074861-9	2017	Importantly, knockdown of Prdx6 revealed that Prdx6 expression was prerequisite for SFN-mediated cytoprotection.	sulforaphane	84-87	peroxiredoxin 6	Homo sapiens	46-51
29018242-1	2017	Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-135
29057804-3	2017	The in vitro treatment of the potent Nrf2 activator sulforaphane increased Nrf2 protein levels and led to the upregulation of phase II antioxidant enzymes.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
29057804-3	2017	The in vitro treatment of the potent Nrf2 activator sulforaphane increased Nrf2 protein levels and led to the upregulation of phase II antioxidant enzymes.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
29018242-1	2017	Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
29018242-1	2017	Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-135
29018242-1	2017	Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
29018242-7	2017	Marker of oxidative stress in SFN-injected Nrf2 +/+ mice were lower than those in uninjected mice following the test.	sulforaphane	30-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
29018242-8	2017	SFN produced greater protection against muscle damage during exhaustive exercise conditions in Nrf2 +/+ mice than in Nrf2 -/- mice.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
29018242-9	2017	SFN-induced Nrf2 upregulation, and its antioxidative effects, might play critical roles in attenuating muscle fatigue via reduction of oxidative stress caused by exhaustive exercise.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	12-16
29018242-11	2017	These results provide new insights into SFN-induced upregulation of Nrf2 and its role in improving exercise performance.	sulforaphane	40-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
28978924-0	2017	Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1alpha/VEGF signalling.	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	101-106
28636290-0	2017	Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
28978924-0	2017	Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1alpha/VEGF signalling.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
28636290-3	2017	OBJECTIVE: This study aims to investigate whether the Nrf2 activator, sulforaphane (SFN), can prevent DOX-induced CHF.	sulforaphane	70-82	NFE2 like bZIP transcription factor 2	Rattus norvegicus	54-58
28636290-3	2017	OBJECTIVE: This study aims to investigate whether the Nrf2 activator, sulforaphane (SFN), can prevent DOX-induced CHF.	sulforaphane	84-87	NFE2 like bZIP transcription factor 2	Rattus norvegicus	54-58
28978924-0	2017	Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1alpha/VEGF signalling.	sulforaphane	0-12	vascular endothelial growth factor A	Homo sapiens	118-122
28636290-10	2017	Furthermore, in cultured H9c2 cardiomyocytes, the protective effect of SFN against DOX-induced fibrotic and inflammatory responses was abolished by Nrf2 silencing.	sulforaphane	71-74	NFE2 like bZIP transcription factor 2	Rattus norvegicus	148-152
28636290-11	2017	CONCLUSION: We arrived at the conclusion that DOX-induced CHF can be prevented by SFN through the upregulation of Nrf2 expression and transcriptional function.	sulforaphane	82-85	NFE2 like bZIP transcription factor 2	Rattus norvegicus	114-118
28688915-7	2017	Incubation experiments were carried out in primary human colon epithelial cells (HCoEpiCs) and revealed significant upregulation of NAD(P)H dehydrogenase [quinone] 1 (up to threefold) and thioredoxin reductase 1 (up to twofold) by 10muM sulforaphane (from broccoli), 5muM carnosol (rosemary), and 20muM cinnamaldehyde (cinnamon).	sulforaphane	237-249	NAD(P)H quinone dehydrogenase 1	Homo sapiens	132-165
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	303-306	interferon gamma	Rattus norvegicus	17-26
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	303-306	C-X-C motif chemokine ligand 9	Rattus norvegicus	72-75
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	303-306	insulin 1	Rattus norvegicus	100-105
28970779-3	2017	Sulforaphane at a concentration of 10 muM effectively inhibited the growth of cancer cells.	sulforaphane	0-12	latexin	Homo sapiens	38-41
28677733-0	2017	Sulforaphane inhibits the interferon-gamma-induced expression of MIG, IP-10 and I-TAC in INS-1 pancreatic beta-cells through the downregulation of IRF-1, STAT-1 and PKB.	sulforaphane	0-12	interferon gamma	Rattus norvegicus	26-42
28677733-0	2017	Sulforaphane inhibits the interferon-gamma-induced expression of MIG, IP-10 and I-TAC in INS-1 pancreatic beta-cells through the downregulation of IRF-1, STAT-1 and PKB.	sulforaphane	0-12	C-X-C motif chemokine ligand 9	Rattus norvegicus	65-68
28677733-0	2017	Sulforaphane inhibits the interferon-gamma-induced expression of MIG, IP-10 and I-TAC in INS-1 pancreatic beta-cells through the downregulation of IRF-1, STAT-1 and PKB.	sulforaphane	0-12	C-X-C motif chemokine ligand 10	Rattus norvegicus	70-75
28677733-0	2017	Sulforaphane inhibits the interferon-gamma-induced expression of MIG, IP-10 and I-TAC in INS-1 pancreatic beta-cells through the downregulation of IRF-1, STAT-1 and PKB.	sulforaphane	0-12	interferon regulatory factor 1	Rattus norvegicus	147-152
28677733-0	2017	Sulforaphane inhibits the interferon-gamma-induced expression of MIG, IP-10 and I-TAC in INS-1 pancreatic beta-cells through the downregulation of IRF-1, STAT-1 and PKB.	sulforaphane	0-12	signal transducer and activator of transcription 1	Rattus norvegicus	154-160
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	138-141	interferon gamma	Rattus norvegicus	17-26
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	138-141	C-X-C motif chemokine ligand 9	Rattus norvegicus	72-75
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	138-141	C-X-C motif chemokine ligand 10	Rattus norvegicus	77-82
28677733-10	2017	Importantly, the IFN-gamma-induced increase in the expression levels of MIG, IP-10 and I-TAC in the INS-1 cells was strongly inhibited by SFN, but not by other natural substances, such as curcumin, sanguinarine, resveratrol, triptolide and epigallocatechin gallate (EGCG), suggesting the specificity of SFN in downregulating the levels of these chemokines.	sulforaphane	138-141	insulin 1	Rattus norvegicus	100-105
28317313-5	2017	Carnosol and sulforaphane most effectively induced protein expression, leading to upregulation of at least five out of the six antioxidative enzymes by a maximum factor of 22.80 +- 6.71 (heme oxygenase 1 by carnosol).	sulforaphane	13-25	heme oxygenase 1	Rattus norvegicus	187-203
28912888-6	2017	Anticancer effects of SFN were mediated by global DNA hypomethylation, decreased levels of DNA methyltransferases (DNMT1, DNMT3B) and diminished pools of N6-methyladenosine (m6A) RNA methylation.	sulforaphane	22-25	DNA methyltransferase 1	Homo sapiens	115-120
28710020-7	2017	Noteworthy, treatment with sulforaphane (SFN), diminished expression of OTA-induced inflammatory cytokines (IL-1beta, IL-6), pro-apoptotic factors (c-myc, PUMA) and microRNAs (miR-382, miR-34a) in male mice.	sulforaphane	27-39	microRNA 382	Mus musculus	176-183
28710020-7	2017	Noteworthy, treatment with sulforaphane (SFN), diminished expression of OTA-induced inflammatory cytokines (IL-1beta, IL-6), pro-apoptotic factors (c-myc, PUMA) and microRNAs (miR-382, miR-34a) in male mice.	sulforaphane	27-39	microRNA 34a	Mus musculus	185-192
28912888-6	2017	Anticancer effects of SFN were mediated by global DNA hypomethylation, decreased levels of DNA methyltransferases (DNMT1, DNMT3B) and diminished pools of N6-methyladenosine (m6A) RNA methylation.	sulforaphane	22-25	DNA methyltransferase 3 beta	Homo sapiens	122-128
28912888-7	2017	SFN (10 microM) also affected microRNA profiles, namely SFN caused upregulation of sixty microRNAs and downregulation of thirty two microRNAs, and SFN promoted statistically significant decrease in the levels of miR-23b, miR-92b, miR-381 and miR-382 in three breast cancer cells.	sulforaphane	0-3	microRNA 23b	Homo sapiens	212-219
28912888-7	2017	SFN (10 microM) also affected microRNA profiles, namely SFN caused upregulation of sixty microRNAs and downregulation of thirty two microRNAs, and SFN promoted statistically significant decrease in the levels of miR-23b, miR-92b, miR-381 and miR-382 in three breast cancer cells.	sulforaphane	0-3	microRNA 92b	Homo sapiens	221-228
28912888-7	2017	SFN (10 microM) also affected microRNA profiles, namely SFN caused upregulation of sixty microRNAs and downregulation of thirty two microRNAs, and SFN promoted statistically significant decrease in the levels of miR-23b, miR-92b, miR-381 and miR-382 in three breast cancer cells.	sulforaphane	0-3	microRNA 381	Homo sapiens	230-237
28912888-7	2017	SFN (10 microM) also affected microRNA profiles, namely SFN caused upregulation of sixty microRNAs and downregulation of thirty two microRNAs, and SFN promoted statistically significant decrease in the levels of miR-23b, miR-92b, miR-381 and miR-382 in three breast cancer cells.	sulforaphane	0-3	microRNA 382	Homo sapiens	242-249
28854561-0	2017	Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.	sulforaphane	0-12	protein arginine methyltransferase 5	Homo sapiens	24-29
28527723-3	2017	Activation of Nrf2 signaling by the antioxidant compound sulforaphane (SFN) leads to enhanced VSVDelta51 spread in OV-resistant cancer cells and improves the therapeutic outcome in different murine syngeneic and xenograft tumor models.	sulforaphane	57-69	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
28527723-3	2017	Activation of Nrf2 signaling by the antioxidant compound sulforaphane (SFN) leads to enhanced VSVDelta51 spread in OV-resistant cancer cells and improves the therapeutic outcome in different murine syngeneic and xenograft tumor models.	sulforaphane	71-74	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
29137315-0	2017	Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
29137315-10	2017	Therefore, the present findings suggested that SFN could effectively protect against DBP-induced testicular oxidative stress injury through Nrf2/ARE signaling pathways in male mice offsprings.	sulforaphane	47-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
28900483-0	2017	Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	73-79
28900483-0	2017	Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells.	sulforaphane	0-12	BCL2 like 11	Homo sapiens	138-141
28900483-0	2017	Sulforaphane Induced Apoptosis via Promotion of Mitochondrial Fusion and ERK1/2-Mediated 26S Proteasome Degradation of Novel Pro-survival Bim and Upregulation of Bax in Human Non-Small Cell Lung Cancer Cells.	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
28900483-1	2017	Previous studies in our laboratory showed that sulforaphane (SFN) induced apoptosis by sustained activation of extracellular regulated protein kinases 1/2 (ERK1/2).	sulforaphane	47-59	mitogen-activated protein kinase 3	Homo sapiens	111-154
28900483-1	2017	Previous studies in our laboratory showed that sulforaphane (SFN) induced apoptosis by sustained activation of extracellular regulated protein kinases 1/2 (ERK1/2).	sulforaphane	47-59	mitogen-activated protein kinase 3	Homo sapiens	156-162
28900483-1	2017	Previous studies in our laboratory showed that sulforaphane (SFN) induced apoptosis by sustained activation of extracellular regulated protein kinases 1/2 (ERK1/2).	sulforaphane	61-64	mitogen-activated protein kinase 3	Homo sapiens	111-154
28900483-1	2017	Previous studies in our laboratory showed that sulforaphane (SFN) induced apoptosis by sustained activation of extracellular regulated protein kinases 1/2 (ERK1/2).	sulforaphane	61-64	mitogen-activated protein kinase 3	Homo sapiens	156-162
28900483-2	2017	However, the underlying mechanisms associated with SFN-induced apoptosis and downstream cascades which are modulated by ERK1/2 were not elucidated.	sulforaphane	51-54	mitogen-activated protein kinase 3	Homo sapiens	120-126
28900483-6	2017	Pro-survival Bim downregulation was shown to induce apoptosis in response to SFN.	sulforaphane	77-80	BCL2 like 11	Homo sapiens	13-16
28854561-0	2017	Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.	sulforaphane	0-12	WD repeat domain 77	Homo sapiens	30-35
28854561-4	2017	We further show that treatment with sulforaphane (SFN), a cancer preventive agent derived from cruciferous vegetables, reduces PRMT5 and MEP50 level and H4R3me2s formation, and this is associated with reduced cell proliferation, invasion and migration.	sulforaphane	36-48	protein arginine methyltransferase 5	Homo sapiens	127-132
28854561-4	2017	We further show that treatment with sulforaphane (SFN), a cancer preventive agent derived from cruciferous vegetables, reduces PRMT5 and MEP50 level and H4R3me2s formation, and this is associated with reduced cell proliferation, invasion and migration.	sulforaphane	36-48	WD repeat domain 77	Homo sapiens	137-142
28854561-4	2017	We further show that treatment with sulforaphane (SFN), a cancer preventive agent derived from cruciferous vegetables, reduces PRMT5 and MEP50 level and H4R3me2s formation, and this is associated with reduced cell proliferation, invasion and migration.	sulforaphane	50-53	protein arginine methyltransferase 5	Homo sapiens	127-132
28854561-4	2017	We further show that treatment with sulforaphane (SFN), a cancer preventive agent derived from cruciferous vegetables, reduces PRMT5 and MEP50 level and H4R3me2s formation, and this is associated with reduced cell proliferation, invasion and migration.	sulforaphane	50-53	WD repeat domain 77	Homo sapiens	137-142
28854561-7	2017	SFN treatment of tumors results in reduced MEP50 level and H4R3me2s formation, confirming that that SFN impacts this complex in vivo.	sulforaphane	0-3	WD repeat domain 77	Homo sapiens	43-48
28550120-7	2017	Importantly, treating HIV-1-infected human MDMs or AMs from HIV-1 transgenic rats with sulforaphane (SFN, an Nrf2 activator) significantly improved their phagocytic function.	sulforaphane	87-99	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113
27774770-8	2017	This was further supported by the fact that activation of Nrf2 by its agonists, tertiary butylhydroquinone (t-BHQ) and sulforaphane (SFN) resulted in the same protective effects against arsenite toxicity.	sulforaphane	119-131	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
27774770-8	2017	This was further supported by the fact that activation of Nrf2 by its agonists, tertiary butylhydroquinone (t-BHQ) and sulforaphane (SFN) resulted in the same protective effects against arsenite toxicity.	sulforaphane	133-136	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
28550120-7	2017	Importantly, treating HIV-1-infected human MDMs or AMs from HIV-1 transgenic rats with sulforaphane (SFN, an Nrf2 activator) significantly improved their phagocytic function.	sulforaphane	101-104	NFE2 like bZIP transcription factor 2	Rattus norvegicus	109-113
28550120-8	2017	The salutary effects of SFN were abrogated by silencing RNA to Nrf2 in wild-type rat macrophages.	sulforaphane	24-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
28515158-10	2017	The Nrf2 activator sulforaphane also increased AQP3 levels, suggesting that AQP3 expression may be regulated by Nrf2.	sulforaphane	19-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8
27318675-5	2017	Nonetheless, high glucose cotreating with mangiferin or sulforaphane, a typical inducer of Nrf2 activation, attenuated the above changes in both central neurons.	sulforaphane	56-68	NFE2 like bZIP transcription factor 2	Rattus norvegicus	91-95
28515158-10	2017	The Nrf2 activator sulforaphane also increased AQP3 levels, suggesting that AQP3 expression may be regulated by Nrf2.	sulforaphane	19-31	aquaporin 3	Mus musculus	47-51
28515158-10	2017	The Nrf2 activator sulforaphane also increased AQP3 levels, suggesting that AQP3 expression may be regulated by Nrf2.	sulforaphane	19-31	aquaporin 3	Mus musculus	76-80
28515158-10	2017	The Nrf2 activator sulforaphane also increased AQP3 levels, suggesting that AQP3 expression may be regulated by Nrf2.	sulforaphane	19-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
31966772-0	2017	Sulforaphane attenuates acute lung injury by inhibiting oxidative stress via Nrf2/HO-1 pathway in a rat sepsis model.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81
31966772-0	2017	Sulforaphane attenuates acute lung injury by inhibiting oxidative stress via Nrf2/HO-1 pathway in a rat sepsis model.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	82-86
31966772-6	2017	Supplementation of SFN significantly enhanced Nrf2 and HO-1 protein expression in the lungs in sepsis.	sulforaphane	19-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-50
31966772-6	2017	Supplementation of SFN significantly enhanced Nrf2 and HO-1 protein expression in the lungs in sepsis.	sulforaphane	19-22	heme oxygenase 1	Rattus norvegicus	55-59
31966772-8	2017	However, these beneficial effects of SFN were reduced by HO-1 inhibition.	sulforaphane	37-40	heme oxygenase 1	Rattus norvegicus	57-61
31966772-9	2017	Therefore, we concluded that SFN attenuated ALI in sepsis by reducing oxidative stress through activating Nrf2/HO-1.	sulforaphane	29-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
31966772-9	2017	Therefore, we concluded that SFN attenuated ALI in sepsis by reducing oxidative stress through activating Nrf2/HO-1.	sulforaphane	29-32	heme oxygenase 1	Rattus norvegicus	111-115
27318675-6	2017	In addition, mangiferin and sulforaphane significantly prevented the formation of advanced glycation end-products (AGEs) reflecting Glo-1 activity, while elevated the level of glutathione, a cofactor of Glo-1 activity and production of gamma-GCS, in high glucose cultured central neurons.	sulforaphane	28-40	glyoxalase 1	Rattus norvegicus	132-137
27318675-6	2017	In addition, mangiferin and sulforaphane significantly prevented the formation of advanced glycation end-products (AGEs) reflecting Glo-1 activity, while elevated the level of glutathione, a cofactor of Glo-1 activity and production of gamma-GCS, in high glucose cultured central neurons.	sulforaphane	28-40	glyoxalase 1	Rattus norvegicus	203-208
27318675-6	2017	In addition, mangiferin and sulforaphane significantly prevented the formation of advanced glycation end-products (AGEs) reflecting Glo-1 activity, while elevated the level of glutathione, a cofactor of Glo-1 activity and production of gamma-GCS, in high glucose cultured central neurons.	sulforaphane	28-40	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	236-245
28586068-0	2017	Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	23-27
28572033-5	2017	Further, Nrf2 gene silencing in human BBB endothelial cells markedly suppressed ABCB10 protein, while Nrf2 activation by sulforaphane up-regulated ABCB10 expression.	sulforaphane	121-133	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
28586068-2	2017	Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	114-147
28586068-2	2017	Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-155
28586068-2	2017	Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	157-161
28586068-2	2017	Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	114-147
28586068-2	2017	Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-155
28586068-2	2017	Sulforaphane (SFN) is an antioxidant agent, which exerts protective effects against cell damage by activating the nuclear factor erythroid 2 like 2 (NFE2L2; Nrf2).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	157-161
26916923-0	2017	Sulforaphane delivery using mPEG-PCL co-polymer nanoparticles to breast cancer cells.	sulforaphane	0-12	PHD finger protein 1	Homo sapiens	33-36
28583601-1	2017	Sulforaphane (SFN) has received a great deal of research attention because of its ability to induce the production of a battery of antioxidant enzymes in certain concentrations through the activation of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which may effectively neutralize reactive oxygen species (ROS) induced oxidative stress.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Bos taurus	252-256
28583601-1	2017	Sulforaphane (SFN) has received a great deal of research attention because of its ability to induce the production of a battery of antioxidant enzymes in certain concentrations through the activation of the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway, which may effectively neutralize reactive oxygen species (ROS) induced oxidative stress.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Bos taurus	252-256
28583601-6	2017	Moreover, the relative expression of the genes (PRDX1, CAT, TXN1and SOD1) downstream to NRF2 activation was found to be highly expressed (fold change ranged from 2 to 5, p < 0.05) in SFN treated GCs compared to the untreated control.	sulforaphane	186-189	peroxiredoxin 1	Bos taurus	48-53
28583601-6	2017	Moreover, the relative expression of the genes (PRDX1, CAT, TXN1and SOD1) downstream to NRF2 activation was found to be highly expressed (fold change ranged from 2 to 5, p < 0.05) in SFN treated GCs compared to the untreated control.	sulforaphane	186-189	catalase	Bos taurus	55-58
28583601-6	2017	Moreover, the relative expression of the genes (PRDX1, CAT, TXN1and SOD1) downstream to NRF2 activation was found to be highly expressed (fold change ranged from 2 to 5, p < 0.05) in SFN treated GCs compared to the untreated control.	sulforaphane	186-189	superoxide dismutase [Cu-Zn]	Bos taurus	68-72
28583601-6	2017	Moreover, the relative expression of the genes (PRDX1, CAT, TXN1and SOD1) downstream to NRF2 activation was found to be highly expressed (fold change ranged from 2 to 5, p < 0.05) in SFN treated GCs compared to the untreated control.	sulforaphane	186-189	NFE2 like bZIP transcription factor 2	Bos taurus	88-92
28572033-5	2017	Further, Nrf2 gene silencing in human BBB endothelial cells markedly suppressed ABCB10 protein, while Nrf2 activation by sulforaphane up-regulated ABCB10 expression.	sulforaphane	121-133	ATP binding cassette subfamily B member 10	Homo sapiens	147-153
28583601-9	2017	The results of this study clearly showed that 10 muM SFN concentration played a crucial role in activating Nrf2 pathway without inducing apoptotic characteristics and this concentration may have beneficial effects in boosting the production of phase II antioxidant enzymes in GCs.	sulforaphane	53-56	NFE2 like bZIP transcription factor 2	Bos taurus	107-111
28389405-7	2017	In contrast, the Nrf2 activator sulforaphane induced all antioxidant genes at as early as 3h.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Homo sapiens	17-21
28690874-0	2017	Sulforaphane-cysteine-induced apoptosis via phosphorylated ERK1/2-mediated maspin pathway in human non-small cell lung cancer cells.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	59-65
28690874-0	2017	Sulforaphane-cysteine-induced apoptosis via phosphorylated ERK1/2-mediated maspin pathway in human non-small cell lung cancer cells.	sulforaphane	0-12	serpin family B member 5	Homo sapiens	75-81
28347842-3	2017	We examined the involvement of heme metabolism in the induction of HO-1 by the inducers sulforaphane and sodium arsenite.	sulforaphane	88-100	heme oxygenase 1	Homo sapiens	67-71
28347842-4	2017	METHODS: We examined the expression of HO-1 in sulforaphane-, sodium arsenite- and CORM3-treated HEK293T cells, by measuring the transcriptional activity and levels of mRNA and protein.	sulforaphane	47-59	heme oxygenase 1	Homo sapiens	39-43
28295950-0	2017	Sulforaphane attenuates di-N-butylphthalate-induced reproductive damage in pubertal mice: Involvement of the Nrf2-antioxidant system.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	109-113
28454500-9	2017	Secondly, considering many known Nrf2 activators, such as DMF and SFN, are electrophilic entities with very small molecular weight, we need to update the concept of how to recognize a drug candidate.	sulforaphane	66-69	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
28408365-5	2017	Activators of Nrf2 (sulforaphane) or Akt (SC79) caused increased MARCO expression and a MARCO-dependent improvement in phagocytosis in IFNgamma-treated cells and improved survival in mice with postinfluenza pneumococcal pneumonia.	sulforaphane	20-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
28408365-5	2017	Activators of Nrf2 (sulforaphane) or Akt (SC79) caused increased MARCO expression and a MARCO-dependent improvement in phagocytosis in IFNgamma-treated cells and improved survival in mice with postinfluenza pneumococcal pneumonia.	sulforaphane	20-32	macrophage receptor with collagenous structure	Mus musculus	65-70
28408365-5	2017	Activators of Nrf2 (sulforaphane) or Akt (SC79) caused increased MARCO expression and a MARCO-dependent improvement in phagocytosis in IFNgamma-treated cells and improved survival in mice with postinfluenza pneumococcal pneumonia.	sulforaphane	20-32	macrophage receptor with collagenous structure	Mus musculus	88-93
28408365-5	2017	Activators of Nrf2 (sulforaphane) or Akt (SC79) caused increased MARCO expression and a MARCO-dependent improvement in phagocytosis in IFNgamma-treated cells and improved survival in mice with postinfluenza pneumococcal pneumonia.	sulforaphane	20-32	interferon gamma	Mus musculus	135-143
28412310-1	2017	Activation of Nrf2 with sulforaphane has recently gained attention as a new therapeutic approach in the treatment of many diseases, including epilepsy.	sulforaphane	24-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
28615356-4	2017	Sulforaphane suppressed glucose production from hepatic cells by nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) and decreased expression of key enzymes in gluconeogenesis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	90-133
28666020-9	2017	Of these, Macrophage Migration Inhibitory Factor is a particularly attractive therapeutic target as sulforaphane, a naturally occurring MIF inhibitor derived from broccoli sprouts, has excellent oral bioavailability.	sulforaphane	100-112	macrophage migration inhibitory factor	Homo sapiens	10-48
28666020-9	2017	Of these, Macrophage Migration Inhibitory Factor is a particularly attractive therapeutic target as sulforaphane, a naturally occurring MIF inhibitor derived from broccoli sprouts, has excellent oral bioavailability.	sulforaphane	100-112	macrophage migration inhibitory factor	Homo sapiens	136-139
28615356-4	2017	Sulforaphane suppressed glucose production from hepatic cells by nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2) and decreased expression of key enzymes in gluconeogenesis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
28487960-3	2017	Sulforaphane (SFN), an Nrf2 activator, additionally regulates excessive oxidative stress by promoting the expression of endogenous antioxidants.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
28431267-0	2017	miR-19 targeting of GSK3beta mediates sulforaphane suppression of lung cancer stem cells.	sulforaphane	38-50	glycogen synthase kinase 3 beta	Homo sapiens	20-28
28487960-0	2017	Sulforaphane prevents bleomycin-induced pulmonary fibrosis in mice by inhibiting oxidative stress via nuclear factor erythroid 2-related factor-2 activation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-145
28487960-3	2017	Sulforaphane (SFN), an Nrf2 activator, additionally regulates excessive oxidative stress by promoting the expression of endogenous antioxidants.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
28487960-15	2017	In conclusion, these results suggested that SFN treatment of pulmonary fibrosis mouse models may attenuate alveolitis, fibrosis, apoptosis and lung oxidative stress by increasing the expression of antioxidant enzymes, including NAPDH quinone oxidoreductase, heme oxygenase-1, superoxide dismutase and catalase, via upregulation of Nrf2 gene expression.	sulforaphane	44-47	crystallin, zeta	Mus musculus	234-256
28487960-15	2017	In conclusion, these results suggested that SFN treatment of pulmonary fibrosis mouse models may attenuate alveolitis, fibrosis, apoptosis and lung oxidative stress by increasing the expression of antioxidant enzymes, including NAPDH quinone oxidoreductase, heme oxygenase-1, superoxide dismutase and catalase, via upregulation of Nrf2 gene expression.	sulforaphane	44-47	heme oxygenase 1	Mus musculus	258-274
28487960-15	2017	In conclusion, these results suggested that SFN treatment of pulmonary fibrosis mouse models may attenuate alveolitis, fibrosis, apoptosis and lung oxidative stress by increasing the expression of antioxidant enzymes, including NAPDH quinone oxidoreductase, heme oxygenase-1, superoxide dismutase and catalase, via upregulation of Nrf2 gene expression.	sulforaphane	44-47	catalase	Mus musculus	301-309
28487960-15	2017	In conclusion, these results suggested that SFN treatment of pulmonary fibrosis mouse models may attenuate alveolitis, fibrosis, apoptosis and lung oxidative stress by increasing the expression of antioxidant enzymes, including NAPDH quinone oxidoreductase, heme oxygenase-1, superoxide dismutase and catalase, via upregulation of Nrf2 gene expression.	sulforaphane	44-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	331-335
28599444-3	2017	Combined treatment of breast cancer cells with SFN and paclitaxel resulted in increased activation of apoptotic signaling pathway members, including caspase-3, -8 and -9, and cytochrome c, compared with treatment with SFN or paclitaxel alone.	sulforaphane	47-50	caspase 3	Homo sapiens	149-169
28498473-10	2017	Due to the fact that SFN did not enhance the DNA platination levels upon cisplatin treatment, SFN may have exerted its activity via the inhibition of the anti-apoptotic proteins Bcl-2 and XIAP, as we observed.	sulforaphane	94-97	BCL2 apoptosis regulator	Homo sapiens	178-183
28498473-10	2017	Due to the fact that SFN did not enhance the DNA platination levels upon cisplatin treatment, SFN may have exerted its activity via the inhibition of the anti-apoptotic proteins Bcl-2 and XIAP, as we observed.	sulforaphane	94-97	X-linked inhibitor of apoptosis	Homo sapiens	188-192
28599444-3	2017	Combined treatment of breast cancer cells with SFN and paclitaxel resulted in increased activation of apoptotic signaling pathway members, including caspase-3, -8 and -9, and cytochrome c, compared with treatment with SFN or paclitaxel alone.	sulforaphane	47-50	cytochrome c, somatic	Homo sapiens	175-187
28599444-5	2017	Furthermore, SFN-paclitaxel-induced apoptosis was inhibited by overexpression of Bcl-2.	sulforaphane	13-16	BCL2 apoptosis regulator	Homo sapiens	81-86
28599444-4	2017	In addition, treatment with SFN and paclitaxel resulted in downregulation of the nuclear factor kappa B signaling pathway, and reduced protein expression of apoptosis regulator Bcl-2 and phosphorylated AKT serine/threonine kinase.	sulforaphane	28-31	BCL2 apoptosis regulator	Homo sapiens	177-182
28599444-4	2017	In addition, treatment with SFN and paclitaxel resulted in downregulation of the nuclear factor kappa B signaling pathway, and reduced protein expression of apoptosis regulator Bcl-2 and phosphorylated AKT serine/threonine kinase.	sulforaphane	28-31	AKT serine/threonine kinase 1	Homo sapiens	202-205
28587109-6	2017	By determining the expression changes of antioxidant genes in MCF7 cells that were treated with the potential Nrf2 activators using quantitative real-time polymerase chain reaction RT-PCR (real-time polymerase chain reaction) (qRT-PCR), astemizole was found to have a greater scale of upregulating antioxidant genes NQO1, HO-1, and GCLM than the positive control d,l-sulforaphane, although the testing concentration was lower than that of the control.	sulforaphane	363-379	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114
28254410-4	2017	Conversely, sulforaphane is capable of preferentially eliminating CSCs, by inhibiting NF-kappaB p65 subunit translocation, downregulating p52 and consequent downstream transcriptional activity.	sulforaphane	12-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	138-141
28507518-0	2017	Beneficial Effects of Sulforaphane Treatment in Alzheimer"s Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression.	sulforaphane	22-34	histone deacetylase 1	Mus musculus	100-105
28507518-0	2017	Beneficial Effects of Sulforaphane Treatment in Alzheimer"s Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression.	sulforaphane	22-34	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	122-128
28507518-4	2017	This study investigated whether the phytochemical sulforaphane, a pan-histone deacetylase inhibitor, up-regulates the p75 neurotrophin receptor expression via affecting histone acetylation in protection against Alzheimer"s disease.	sulforaphane	50-62	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	118-143
28507518-6	2017	Additionally, sulforaphane reduced the expression of histone deacetylase1, 2, and 3, up-regulated p75 neurotrophin receptor, and increased levels of acetylated histone 3 lysine 9 and acetylated histone 4 lysine 12 in the cerebral cortex of Alzheimer"s disease model mice as well as in Abeta-exposed SH-SY5Y cells.	sulforaphane	14-26	histone deacetylase 1	Mus musculus	53-83
28507518-6	2017	Additionally, sulforaphane reduced the expression of histone deacetylase1, 2, and 3, up-regulated p75 neurotrophin receptor, and increased levels of acetylated histone 3 lysine 9 and acetylated histone 4 lysine 12 in the cerebral cortex of Alzheimer"s disease model mice as well as in Abeta-exposed SH-SY5Y cells.	sulforaphane	14-26	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	98-123
28507518-6	2017	Additionally, sulforaphane reduced the expression of histone deacetylase1, 2, and 3, up-regulated p75 neurotrophin receptor, and increased levels of acetylated histone 3 lysine 9 and acetylated histone 4 lysine 12 in the cerebral cortex of Alzheimer"s disease model mice as well as in Abeta-exposed SH-SY5Y cells.	sulforaphane	14-26	histocompatibility 2, class II antigen A, beta 1	Mus musculus	285-290
28507518-8	2017	In conclusion, this study demonstrates that sulforaphane can ameliorate neurobehavioral deficits and reduce the Abeta burden in Alzheimer"s disease model mice, and the mechanism underlying these effects may be associated with up-regulation of p75 neurotrophin receptor mediated, apparently at least in part, via reducing the expression of histone deacetylase1 and 3.	sulforaphane	44-56	histocompatibility 2, class II antigen A, beta 1	Mus musculus	112-117
28507518-8	2017	In conclusion, this study demonstrates that sulforaphane can ameliorate neurobehavioral deficits and reduce the Abeta burden in Alzheimer"s disease model mice, and the mechanism underlying these effects may be associated with up-regulation of p75 neurotrophin receptor mediated, apparently at least in part, via reducing the expression of histone deacetylase1 and 3.	sulforaphane	44-56	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	243-268
28507518-8	2017	In conclusion, this study demonstrates that sulforaphane can ameliorate neurobehavioral deficits and reduce the Abeta burden in Alzheimer"s disease model mice, and the mechanism underlying these effects may be associated with up-regulation of p75 neurotrophin receptor mediated, apparently at least in part, via reducing the expression of histone deacetylase1 and 3.	sulforaphane	44-56	histone deacetylase 1	Mus musculus	339-365
28151586-3	2017	We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function.	sulforaphane	87-99	NFE2 like bZIP transcription factor 2	Homo sapiens	28-64
28083623-9	2017	SFN was found to promote MAPK signaling, and inhibition of ERK activation using U0126 prevented SFN-induced LC3-II elevation and vesicle formation.	sulforaphane	96-99	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	108-111
28083623-14	2017	SFN promotes MAPK signaling, and inhibition of MEK can suppress SFN-induced autophagy.	sulforaphane	64-67	mitogen-activated protein kinase kinase 7	Homo sapiens	47-50
28151586-3	2017	We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function.	sulforaphane	87-99	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
28151586-3	2017	We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function.	sulforaphane	101-104	NFE2 like bZIP transcription factor 2	Homo sapiens	28-64
28151586-3	2017	We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function.	sulforaphane	101-104	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
28151586-6	2017	HSNECs were stimulated with HDM with or without pharmacologic activation of Nrf2 with SFN.	sulforaphane	86-89	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
28151586-10	2017	Enhancing Nrf2 activation through treatment with SFN prior to stimulation with HDM was associated with increased localization of ZO-1 at the cell surface and statistically significant increases in TER (p < 0.05) and decrease in paracellular FITC-dextran permeability (p < 0.001).	sulforaphane	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
28151586-10	2017	Enhancing Nrf2 activation through treatment with SFN prior to stimulation with HDM was associated with increased localization of ZO-1 at the cell surface and statistically significant increases in TER (p < 0.05) and decrease in paracellular FITC-dextran permeability (p < 0.001).	sulforaphane	49-52	tight junction protein 1	Homo sapiens	129-133
28112972-7	2017	SFN (0.5 mg/kg, orally) for 7 days significantly boosted liver function biomarkers; it reduced serum alanine transaminase, aspartate aminotransferase, and alkaline phosphatase, and restored serum albumin concentration in a significant manner.	sulforaphane	0-3	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	123-149
28420123-7	2017	Total isothiocyanates, increased by 133% immediately in CS4, and after storage CS1 showed 65% higher levels of sulforaphane.	sulforaphane	111-123	myozenin 2	Homo sapiens	79-82
28393231-1	2017	We previously demonstrated that sulforaphane (SFN) inhibited invasion via sustained activation of ERK1/2 in human glioblastoma cells.	sulforaphane	32-44	mitogen-activated protein kinase 3	Homo sapiens	98-104
28393231-1	2017	We previously demonstrated that sulforaphane (SFN) inhibited invasion via sustained activation of ERK1/2 in human glioblastoma cells.	sulforaphane	46-49	mitogen-activated protein kinase 3	Homo sapiens	98-104
28393231-8	2017	Our results showed that SFN-Cys induced cell apoptosis via sustained activation of ERK1/2 and the ERK1/2 mediated signaling pathways such as activation of caspase 3 and apoptosis-related proteins, thus indicating that SFN-Cys might be a more promising therapeutic agent versus SFN to resist glioblastoma cells, especially in Taxol-resistant cancer cells.	sulforaphane	24-27	mitogen-activated protein kinase 3	Homo sapiens	83-89
28393231-8	2017	Our results showed that SFN-Cys induced cell apoptosis via sustained activation of ERK1/2 and the ERK1/2 mediated signaling pathways such as activation of caspase 3 and apoptosis-related proteins, thus indicating that SFN-Cys might be a more promising therapeutic agent versus SFN to resist glioblastoma cells, especially in Taxol-resistant cancer cells.	sulforaphane	24-27	mitogen-activated protein kinase 3	Homo sapiens	98-104
28393231-8	2017	Our results showed that SFN-Cys induced cell apoptosis via sustained activation of ERK1/2 and the ERK1/2 mediated signaling pathways such as activation of caspase 3 and apoptosis-related proteins, thus indicating that SFN-Cys might be a more promising therapeutic agent versus SFN to resist glioblastoma cells, especially in Taxol-resistant cancer cells.	sulforaphane	24-27	caspase 3	Homo sapiens	155-164
28212891-0	2017	Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation.	sulforaphane	0-12	mechanistic target of rapamycin kinase	Homo sapiens	116-120
28212891-2	2017	The present study has examined the likely regulatory effects of sulforaphane (SFN, an antioxidant) on Nrf2 activation and platelet-derived growth factor (PDGF)-induced mTOR signaling in VSMCs.	sulforaphane	64-76	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
28212891-2	2017	The present study has examined the likely regulatory effects of sulforaphane (SFN, an antioxidant) on Nrf2 activation and platelet-derived growth factor (PDGF)-induced mTOR signaling in VSMCs.	sulforaphane	78-81	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	heme oxygenase 1	Homo sapiens	82-98
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	mechanistic target of rapamycin kinase	Homo sapiens	244-248
28212891-9	2017	Although SFN promotes Nrf2 accumulation to upregulate cytoprotective genes (e.g., heme oxygenase-1 and thioredoxin-1), downregulation of endogenous Nrf2 by target-specific siRNA reveals an Nrf2-independent effect for SFN-mediated inhibition of mTOR/p70S6K/S6 signaling and suppression of VSMC proliferation.	sulforaphane	9-12	ribosomal protein S6 kinase B1	Homo sapiens	249-255
28117948-3	2017	Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	61-104
28117948-3	2017	Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	106-111
28117948-3	2017	Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	61-104
28117948-3	2017	Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	106-111
28131897-8	2017	LINC01116 was functionally investigated because it was overexpressed in several cancers, and was transcriptionally repressed after SFN treatment.	sulforaphane	131-134	long intergenic non-protein coding RNA 1116	Homo sapiens	0-9
28110122-8	2017	Otherwise, ERK1/2 and Akt signaling pathways seem to be involved, as the presence of specific inhibitors of these kinases reduced the protective effect of sulforaphane in the presence of 17beta-estradiol.	sulforaphane	155-167	mitogen activated protein kinase 3	Rattus norvegicus	11-17
28110122-8	2017	Otherwise, ERK1/2 and Akt signaling pathways seem to be involved, as the presence of specific inhibitors of these kinases reduced the protective effect of sulforaphane in the presence of 17beta-estradiol.	sulforaphane	155-167	AKT serine/threonine kinase 1	Rattus norvegicus	22-25
28189971-0	2017	Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Rattus norvegicus	96-101
28189971-5	2017	In this study, we focus our investigation on the role and process of Sulforaphane in the inhibition of NLRP3 inflammasome activation, as well as its effect on brain ischemia/reperfusion injury.	sulforaphane	69-81	NLR family, pyrin domain containing 3	Rattus norvegicus	103-108
28189971-12	2017	Sulforaphane treatment inhibits NLRP3 inflammasome activation and the downregulation of cleaved caspase-1, while reducing IL-1beta and IL-18 expression.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Rattus norvegicus	32-37
28189971-12	2017	Sulforaphane treatment inhibits NLRP3 inflammasome activation and the downregulation of cleaved caspase-1, while reducing IL-1beta and IL-18 expression.	sulforaphane	0-12	interleukin 1 beta	Rattus norvegicus	122-130
28189971-12	2017	Sulforaphane treatment inhibits NLRP3 inflammasome activation and the downregulation of cleaved caspase-1, while reducing IL-1beta and IL-18 expression.	sulforaphane	0-12	interleukin 18	Rattus norvegicus	135-140
28189971-14	2017	This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18.	sulforaphane	49-61	NLR family, pyrin domain containing 3	Rattus norvegicus	72-77
28189971-14	2017	This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18.	sulforaphane	49-61	NLR family, pyrin domain containing 3	Rattus norvegicus	134-139
28189971-14	2017	This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18.	sulforaphane	49-61	interleukin 1 beta	Rattus norvegicus	203-211
28189971-14	2017	This neuroprotective effect is likely exerted by Sulforaphane inhibited NLRP3 inflammasome activation caused by the downregulation of NLRP3, the induction of cleaved caspase-1, and thus the reduction of IL-1beta and IL-18.	sulforaphane	49-61	interleukin 18	Rattus norvegicus	216-221
27889639-0	2017	Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
26639573-2	2017	Sulforaphane (SFN) activates the transcription factor nuclear factor E2-related factor 2 (Nrf2), which upregulates antioxidant genes and lowers inflammation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-88
26639573-2	2017	Sulforaphane (SFN) activates the transcription factor nuclear factor E2-related factor 2 (Nrf2), which upregulates antioxidant genes and lowers inflammation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
26639573-2	2017	Sulforaphane (SFN) activates the transcription factor nuclear factor E2-related factor 2 (Nrf2), which upregulates antioxidant genes and lowers inflammation.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-88
26639573-2	2017	Sulforaphane (SFN) activates the transcription factor nuclear factor E2-related factor 2 (Nrf2), which upregulates antioxidant genes and lowers inflammation.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
27889639-6	2017	These data demonstrate that the beneficial properties of SFN extend beyond activation of the KEAP1-Nrf2-ARE system and warrant further interrogation given the current use of this agent in multiple clinical trials.	sulforaphane	57-60	kelch like ECH associated protein 1	Homo sapiens	93-98
27889639-6	2017	These data demonstrate that the beneficial properties of SFN extend beyond activation of the KEAP1-Nrf2-ARE system and warrant further interrogation given the current use of this agent in multiple clinical trials.	sulforaphane	57-60	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
27860235-0	2017	A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.	sulforaphane	94-106	NmrA like redox sensor 2, pseudogene	Homo sapiens	25-32
27860235-0	2017	A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.	sulforaphane	94-106	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
27860235-0	2017	A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.	sulforaphane	94-106	NAD(P)H quinone dehydrogenase 1	Homo sapiens	86-90
27860235-1	2017	SCOPE: The anticancer agent sulforaphane (SFN) acts via multiple mechanisms to modulate gene expression, including the induction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent signaling and the inhibition of histone deacetylase activity.	sulforaphane	28-40	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
27860235-1	2017	SCOPE: The anticancer agent sulforaphane (SFN) acts via multiple mechanisms to modulate gene expression, including the induction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent signaling and the inhibition of histone deacetylase activity.	sulforaphane	42-45	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
27860235-4	2017	In addition to NAD(P)H quinone dehydrogenase 1 (NQO1) and other well-known Nrf2-dependent targets, SFN strongly induced the expression of Loc344887.	sulforaphane	99-102	NAD(P)H quinone dehydrogenase 1	Homo sapiens	15-46
27860235-4	2017	In addition to NAD(P)H quinone dehydrogenase 1 (NQO1) and other well-known Nrf2-dependent targets, SFN strongly induced the expression of Loc344887.	sulforaphane	99-102	NAD(P)H quinone dehydrogenase 1	Homo sapiens	48-52
27860235-4	2017	In addition to NAD(P)H quinone dehydrogenase 1 (NQO1) and other well-known Nrf2-dependent targets, SFN strongly induced the expression of Loc344887.	sulforaphane	99-102	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
27889639-5	2017	Mechanistically, SFN mitigates the recruitment and/or retention of the soluble fission factor Drp1 to mitochondria and to peroxisomes but does not affect overall Drp1 abundance.	sulforaphane	17-20	collapsin response mediator protein 1	Homo sapiens	94-98
27889639-2	2017	Sulforaphane (SFN), an electrophilic isothiocyanate derived from cruciferous vegetables, activates the KEAP1-Nrf2-ARE pathway and has become a molecule-of-interest in the treatment of diseases in which chronic oxidative stress plays a major etiological role.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	103-108
27889639-2	2017	Sulforaphane (SFN), an electrophilic isothiocyanate derived from cruciferous vegetables, activates the KEAP1-Nrf2-ARE pathway and has become a molecule-of-interest in the treatment of diseases in which chronic oxidative stress plays a major etiological role.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
27889639-2	2017	Sulforaphane (SFN), an electrophilic isothiocyanate derived from cruciferous vegetables, activates the KEAP1-Nrf2-ARE pathway and has become a molecule-of-interest in the treatment of diseases in which chronic oxidative stress plays a major etiological role.	sulforaphane	14-17	kelch like ECH associated protein 1	Homo sapiens	103-108
27889639-2	2017	Sulforaphane (SFN), an electrophilic isothiocyanate derived from cruciferous vegetables, activates the KEAP1-Nrf2-ARE pathway and has become a molecule-of-interest in the treatment of diseases in which chronic oxidative stress plays a major etiological role.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
27889639-4	2017	Mitochondrial fusion has been reported to be cytoprotective by inhibiting pore formation in mitochondria during apoptosis, and consistent with this, we show Nrf2-independent, cytoprotection of SFN-treated cells exposed to the apoptosis-inducer, staurosporine.	sulforaphane	193-196	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
28298215-9	2017	RESULTS: We observed increased microvascular expression of Abcc1, Abcc2, and Abcc4 mRNA following H/R treatment with reoxygenation times of 10 min, 30 min, and 1 h and in animals treated with sulforaphane.	sulforaphane	192-204	ATP binding cassette subfamily C member 1	Rattus norvegicus	59-64
28298215-11	2017	ChIP studies showed increased Nrf2 binding to antioxidant response elements on Abcc1, Abcc2, and Abcc4 promoters following H/R or sulforaphane treatment, suggesting a role for Nrf2 signaling in Abcc gene regulation.	sulforaphane	130-142	ATP binding cassette subfamily C member 2	Rattus norvegicus	86-91
28120534-5	2017	Moreover, sulforaphane markedly suppressed the expression of IL-6 and alpha-SMA and inhibited Stat3 and Smad3 signaling pathways in keloid fibroblast KF112 cells.	sulforaphane	10-22	interleukin 6	Homo sapiens	61-65
28120534-5	2017	Moreover, sulforaphane markedly suppressed the expression of IL-6 and alpha-SMA and inhibited Stat3 and Smad3 signaling pathways in keloid fibroblast KF112 cells.	sulforaphane	10-22	signal transducer and activator of transcription 3	Homo sapiens	94-99
28120534-5	2017	Moreover, sulforaphane markedly suppressed the expression of IL-6 and alpha-SMA and inhibited Stat3 and Smad3 signaling pathways in keloid fibroblast KF112 cells.	sulforaphane	10-22	SMAD family member 3	Homo sapiens	104-109
28120534-6	2017	Sulforaphane induced G2/M cell-cycle arrest with the induction of p21 in KF112 cells.	sulforaphane	0-12	H3 histone pseudogene 16	Homo sapiens	66-69
28120534-8	2017	Furthermore, sulforaphane suppressed IL-6, Stat3, and Smad3 signaling in the coculture system.	sulforaphane	13-25	interleukin 6	Homo sapiens	37-41
28120534-8	2017	Furthermore, sulforaphane suppressed IL-6, Stat3, and Smad3 signaling in the coculture system.	sulforaphane	13-25	signal transducer and activator of transcription 3	Homo sapiens	43-48
28120534-8	2017	Furthermore, sulforaphane suppressed IL-6, Stat3, and Smad3 signaling in the coculture system.	sulforaphane	13-25	SMAD family member 3	Homo sapiens	54-59
28298215-11	2017	ChIP studies showed increased Nrf2 binding to antioxidant response elements on Abcc1, Abcc2, and Abcc4 promoters following H/R or sulforaphane treatment, suggesting a role for Nrf2 signaling in Abcc gene regulation.	sulforaphane	130-142	ATP binding cassette subfamily C member 4	Rattus norvegicus	97-102
28298215-11	2017	ChIP studies showed increased Nrf2 binding to antioxidant response elements on Abcc1, Abcc2, and Abcc4 promoters following H/R or sulforaphane treatment, suggesting a role for Nrf2 signaling in Abcc gene regulation.	sulforaphane	130-142	NFE2 like bZIP transcription factor 2	Rattus norvegicus	176-180
28298215-9	2017	RESULTS: We observed increased microvascular expression of Abcc1, Abcc2, and Abcc4 mRNA following H/R treatment with reoxygenation times of 10 min, 30 min, and 1 h and in animals treated with sulforaphane.	sulforaphane	192-204	ATP binding cassette subfamily C member 2	Rattus norvegicus	66-71
28298215-9	2017	RESULTS: We observed increased microvascular expression of Abcc1, Abcc2, and Abcc4 mRNA following H/R treatment with reoxygenation times of 10 min, 30 min, and 1 h and in animals treated with sulforaphane.	sulforaphane	192-204	ATP binding cassette subfamily C member 4	Rattus norvegicus	77-82
28298215-10	2017	Using a biotinylated Nrf2 probe, we observed an upward band shift in brain microvessels isolated from H/R animals or animals administered sulforaphane.	sulforaphane	138-150	NFE2 like bZIP transcription factor 2	Rattus norvegicus	21-25
28298215-11	2017	ChIP studies showed increased Nrf2 binding to antioxidant response elements on Abcc1, Abcc2, and Abcc4 promoters following H/R or sulforaphane treatment, suggesting a role for Nrf2 signaling in Abcc gene regulation.	sulforaphane	130-142	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
28298215-11	2017	ChIP studies showed increased Nrf2 binding to antioxidant response elements on Abcc1, Abcc2, and Abcc4 promoters following H/R or sulforaphane treatment, suggesting a role for Nrf2 signaling in Abcc gene regulation.	sulforaphane	130-142	ATP binding cassette subfamily C member 1	Rattus norvegicus	79-84
28132875-2	2017	Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition).	sulforaphane	53-65	histone deacetylase 9	Homo sapiens	112-131
28115273-11	2017	Findings from in vitro study revealed that stimulation of Nrf2 using sulforaphane (10muM) negated Akt2 ablation-offered beneficial effect against paraquat whereas inhibition of Nrf2 using luteolin (20muM) mimicked Akt2 ablation-induced beneficial effect against paraquat challenge.	sulforaphane	69-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
28115273-11	2017	Findings from in vitro study revealed that stimulation of Nrf2 using sulforaphane (10muM) negated Akt2 ablation-offered beneficial effect against paraquat whereas inhibition of Nrf2 using luteolin (20muM) mimicked Akt2 ablation-induced beneficial effect against paraquat challenge.	sulforaphane	69-81	thymoma viral proto-oncogene 2	Mus musculus	98-102
28115273-11	2017	Findings from in vitro study revealed that stimulation of Nrf2 using sulforaphane (10muM) negated Akt2 ablation-offered beneficial effect against paraquat whereas inhibition of Nrf2 using luteolin (20muM) mimicked Akt2 ablation-induced beneficial effect against paraquat challenge.	sulforaphane	69-81	thymoma viral proto-oncogene 2	Mus musculus	214-218
28132875-2	2017	Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition).	sulforaphane	53-65	histone deacetylase 9	Homo sapiens	133-137
28132875-2	2017	Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition).	sulforaphane	67-70	histone deacetylase 9	Homo sapiens	112-131
28132875-2	2017	Cruciferous vegetable isothiocyanates (ITCs), namely sulforaphane (SFN) and erucin (ECN), significantly inhibit histone deacetylase (HDAC) activity in human bladder cancer cells representing superficial to invasive biology (59-83% inhibition with 20muM, 48h treatment), and in bladder cancer xenografts (59+-3% ECN inhibition).	sulforaphane	67-70	histone deacetylase 9	Homo sapiens	133-137
27154770-3	2017	The aim of this study was to verify whether combinations of lapatinib with one of isothiocyanates (sulforaphane, erucin or sulforaphene), targeting different levels of HER2 signaling pathway, exert stronger cytotoxic effect than therapy targeting the receptor only, using heterogeneous populations consisting of lapatinib-sensitive and lapatinib-resistant breast cancer cells.	sulforaphane	99-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	168-172
28142224-10	2017	SFN treatment upregulated Wnt signaling in the NSCs, whereas DKK-1 attenuated the effects of SFN.	sulforaphane	93-96	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	61-66
27889290-2	2017	Treatment with nuclear factor (erythroid-derived 2)-like 2 inducer sulforaphane ameliorated skin blistering in Krt14-null mice, correlating with induction of K17.	sulforaphane	67-79	keratin 14	Mus musculus	111-116
27889290-2	2017	Treatment with nuclear factor (erythroid-derived 2)-like 2 inducer sulforaphane ameliorated skin blistering in Krt14-null mice, correlating with induction of K17.	sulforaphane	67-79	keratin 17	Mus musculus	158-161
26415122-5	2017	RESULTS: Cross talk was detected between the three signaling pathways upon some types of redox therapeutics, also by using inducers typically considered specific for Nrf2, such as sulforaphane or auranofin, hypoxia for HIF activation, or tumor necrosis factor alpha (TNFalpha) for NF-kappaB stimulation.	sulforaphane	180-192	bone morphogenetic protein receptor type 2	Homo sapiens	15-19
28011874-0	2017	Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin.	sulforaphane	124-136	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
28011874-0	2017	Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin.	sulforaphane	124-136	matrix metallopeptidase 1	Homo sapiens	40-45
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	47-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	47-59	matrix metallopeptidase 13	Mus musculus	131-136
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	47-59	jun proto-oncogene	Mus musculus	247-252
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	47-59	mitogen-activated protein kinase 14	Mus musculus	276-279
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	47-59	jun proto-oncogene	Mus musculus	282-287
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	47-59	FBJ osteosarcoma oncogene	Mus musculus	293-298
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	61-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	61-64	matrix metallopeptidase 13	Mus musculus	131-136
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	61-64	jun proto-oncogene	Mus musculus	247-252
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	61-64	mitogen-activated protein kinase 14	Mus musculus	276-279
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	61-64	jun proto-oncogene	Mus musculus	282-287
28011874-4	2017	Antiphotoaging effects of hispidulin (HPD) and sulforaphane (SFN) were assessed on their abilities to activate Nrf2 in controlling MMP-1 and collagen expressions in association with phosphorylation of MAPKs (extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38), c-Jun, and c-Fos, using the skin of BALB/c mice subjected to repetitive UVA irradiation.	sulforaphane	61-64	FBJ osteosarcoma oncogene	Mus musculus	293-298
26415122-5	2017	RESULTS: Cross talk was detected between the three signaling pathways upon some types of redox therapeutics, also by using inducers typically considered specific for Nrf2, such as sulforaphane or auranofin, hypoxia for HIF activation, or tumor necrosis factor alpha (TNFalpha) for NF-kappaB stimulation.	sulforaphane	180-192	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
28830206-0	2017	Sulforaphane Reduces HMGB1-Mediated Septic Responses and Improves Survival Rate in Septic Mice.	sulforaphane	0-12	high mobility group box 1	Mus musculus	21-26
27903744-1	2017	We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1 and type 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription factor erythroid 2-related factor 2 (Nrf2) and metallothionein (MT).	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	214-218
27903744-1	2017	We have reported that sulforaphane (SFN) prevented diabetic cardiomyopathy in both type 1 and type 2 diabetes (T2DM) animal models via the upregulation of nuclear transcription factor erythroid 2-related factor 2 (Nrf2) and metallothionein (MT).	sulforaphane	36-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	214-218
27903744-2	2017	In this study, we tested whether SFN protects the heart from T2DM directly through Nrf2, MT, or both.	sulforaphane	33-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
27903744-6	2017	SFN prevented diabetes-induced cardiac dysfunction as well as diabetes-associated cardiac oxidative damage, inflammation, fibrosis, and hypertrophy, with increases in Nrf2 and MT expressions in the WT mice.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	167-171
27903744-9	2017	SFN did not induce MT expression in Nrf2-KO mice, but stimulated Nrf2 function in MT-KO mice.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
27993529-6	2017	The knockdown in the nuclear respiratory factor-1 (NRF1) attenuated the SFN-induced effect on prostate cancer cells demonstrating that mitochondrial biogenesis plays an important role in cell death for this kind of tumor cells.	sulforaphane	72-75	nuclear respiratory factor 1	Homo sapiens	21-49
27993529-6	2017	The knockdown in the nuclear respiratory factor-1 (NRF1) attenuated the SFN-induced effect on prostate cancer cells demonstrating that mitochondrial biogenesis plays an important role in cell death for this kind of tumor cells.	sulforaphane	72-75	nuclear respiratory factor 1	Homo sapiens	51-55
27735126-0	2017	Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways.	sulforaphane	0-12	brain derived neurotrophic factor	Mus musculus	46-50
27735126-0	2017	Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways.	sulforaphane	0-12	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	66-70
27735126-2	2017	We investigated the effect of sulforaphane, a hydrolysis product of glucoraphanin present in Brassica vegetables, on neuronal BDNF expression and its synaptic signaling pathways.	sulforaphane	30-42	brain derived neurotrophic factor	Mus musculus	126-130
27735126-4	2017	Sulforaphane enhanced neuronal BDNF expression and increased levels of neuronal and synaptic molecules such as MAP2, synaptophysin, and PSD-95 in primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	brain derived neurotrophic factor	Mus musculus	31-35
27735126-4	2017	Sulforaphane enhanced neuronal BDNF expression and increased levels of neuronal and synaptic molecules such as MAP2, synaptophysin, and PSD-95 in primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	microtubule-associated protein 2	Mus musculus	111-115
27735126-4	2017	Sulforaphane enhanced neuronal BDNF expression and increased levels of neuronal and synaptic molecules such as MAP2, synaptophysin, and PSD-95 in primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	synaptophysin	Mus musculus	117-130
27735126-4	2017	Sulforaphane enhanced neuronal BDNF expression and increased levels of neuronal and synaptic molecules such as MAP2, synaptophysin, and PSD-95 in primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	discs large MAGUK scaffold protein 4	Mus musculus	136-142
27735126-5	2017	Sulforaphane elevated levels of synaptic TrkB signaling pathway components, including CREB, CaMKII, ERK, and Akt in both primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	41-45
27735126-5	2017	Sulforaphane elevated levels of synaptic TrkB signaling pathway components, including CREB, CaMKII, ERK, and Akt in both primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	cAMP responsive element binding protein 1	Mus musculus	86-90
27735126-5	2017	Sulforaphane elevated levels of synaptic TrkB signaling pathway components, including CREB, CaMKII, ERK, and Akt in both primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	mitogen-activated protein kinase 1	Mus musculus	100-103
27735126-5	2017	Sulforaphane elevated levels of synaptic TrkB signaling pathway components, including CREB, CaMKII, ERK, and Akt in both primary cortical neurons and 3 x Tg-AD mice.	sulforaphane	0-12	thymoma viral proto-oncogene 1	Mus musculus	109-112
27735126-6	2017	Sulforaphane increased global acetylation of histone 3 (H3) and H4, inhibited HDAC activity, and decreased the level of HDAC2 in primary cortical neurons.	sulforaphane	0-12	histone deacetylase 2	Mus musculus	120-125
27735126-7	2017	Chromatin immunoprecipitation analysis revealed that sulforaphane increased acetylated H3 and H4 at BDNF promoters, suggesting that sulforaphane regulates BDNF expression via HDAC inhibition.	sulforaphane	53-65	brain derived neurotrophic factor	Mus musculus	100-104
27735126-7	2017	Chromatin immunoprecipitation analysis revealed that sulforaphane increased acetylated H3 and H4 at BDNF promoters, suggesting that sulforaphane regulates BDNF expression via HDAC inhibition.	sulforaphane	53-65	brain derived neurotrophic factor	Mus musculus	155-159
27735126-7	2017	Chromatin immunoprecipitation analysis revealed that sulforaphane increased acetylated H3 and H4 at BDNF promoters, suggesting that sulforaphane regulates BDNF expression via HDAC inhibition.	sulforaphane	132-144	brain derived neurotrophic factor	Mus musculus	155-159
27735126-8	2017	CONCLUSION: These findings suggest that sulforaphane has the potential to prevent neuronal disorders such as Alzheimer"s disease by epigenetically enhancing neuronal BDNF expression and its TrkB signaling pathways.	sulforaphane	40-52	brain derived neurotrophic factor	Mus musculus	166-170
27735126-8	2017	CONCLUSION: These findings suggest that sulforaphane has the potential to prevent neuronal disorders such as Alzheimer"s disease by epigenetically enhancing neuronal BDNF expression and its TrkB signaling pathways.	sulforaphane	40-52	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	190-194
28076844-0	2017	Sulforaphane inhibits cancer stem-like cell properties and cisplatin resistance through miR-214-mediated downregulation of c-MYC in non-small cell lung cancer.	sulforaphane	0-12	microRNA 214	Homo sapiens	88-95
28076844-0	2017	Sulforaphane inhibits cancer stem-like cell properties and cisplatin resistance through miR-214-mediated downregulation of c-MYC in non-small cell lung cancer.	sulforaphane	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	123-128
28076844-2	2017	SFN exerted these functions through upregulation of miR-214, which in turn targets the coding region of c-MYC.	sulforaphane	0-3	microRNA 214	Homo sapiens	52-59
28076844-2	2017	SFN exerted these functions through upregulation of miR-214, which in turn targets the coding region of c-MYC.	sulforaphane	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-109
28076844-4	2017	Further, we showed that the reported inhibitory effects of SFN on beta-catenin are also mediated by miR-214.	sulforaphane	59-62	catenin beta 1	Homo sapiens	66-78
28076844-4	2017	Further, we showed that the reported inhibitory effects of SFN on beta-catenin are also mediated by miR-214.	sulforaphane	59-62	microRNA 214	Homo sapiens	100-107
28062182-6	2017	Finally, the transfection of CFTRdelF508 but not its wild type counterpart decreases basal, planktonic PsaDM and sulforaphane-driven NRF2 luciferase reporter activity in BEAS-2B cells.	sulforaphane	113-125	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
27890917-0	2017	Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3beta/beta-catenin signaling pathways.	sulforaphane	0-12	microRNA 616	Homo sapiens	72-79
27890917-0	2017	Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3beta/beta-catenin signaling pathways.	sulforaphane	0-12	glycogen synthase kinase 3 beta	Homo sapiens	92-100
27890917-0	2017	Sulforaphane suppresses EMT and metastasis in human lung cancer through miR-616-5p-mediated GSK3beta/beta-catenin signaling pathways.	sulforaphane	0-12	catenin beta 1	Homo sapiens	101-113
27890917-8	2017	Consistent with the clinic observation, miR-616-5p levels in the 3 NSCLC cell lines were correlated with their metastatic ability, and were decreased by sulforaphane treatment.	sulforaphane	153-165	microRNA 6165	Homo sapiens	40-50
27890917-10	2017	Further studies revealed that miR-616-5p directly targeted GSK3beta and decreased its expression, whereas sulforaphane decreased miR-616-5p levels by histone modification, and followed by inactivation of the GSK3beta/beta-catenin signaling pathway and inhibition of EMT, which was characterized by loss of epithelial markers and acquisition of a mesenchymal phenotype in NSCLC cells.	sulforaphane	106-118	microRNA 6165	Homo sapiens	129-139
27890917-10	2017	Further studies revealed that miR-616-5p directly targeted GSK3beta and decreased its expression, whereas sulforaphane decreased miR-616-5p levels by histone modification, and followed by inactivation of the GSK3beta/beta-catenin signaling pathway and inhibition of EMT, which was characterized by loss of epithelial markers and acquisition of a mesenchymal phenotype in NSCLC cells.	sulforaphane	106-118	glycogen synthase kinase 3 beta	Homo sapiens	208-216
28054242-6	2017	We observed that SFN dose-dependently attenuated CCI-induced pain behavioral hypersensitivity, accompanied by reduction in pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and upregulation of an anti-inflammatory cytokine (IL-10).	sulforaphane	17-20	tumor necrosis factor	Mus musculus	151-160
28054242-6	2017	We observed that SFN dose-dependently attenuated CCI-induced pain behavioral hypersensitivity, accompanied by reduction in pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and upregulation of an anti-inflammatory cytokine (IL-10).	sulforaphane	17-20	interleukin 1 beta	Mus musculus	162-170
28054242-6	2017	We observed that SFN dose-dependently attenuated CCI-induced pain behavioral hypersensitivity, accompanied by reduction in pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and upregulation of an anti-inflammatory cytokine (IL-10).	sulforaphane	17-20	interleukin 6	Mus musculus	172-176
28054242-6	2017	We observed that SFN dose-dependently attenuated CCI-induced pain behavioral hypersensitivity, accompanied by reduction in pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and upregulation of an anti-inflammatory cytokine (IL-10).	sulforaphane	17-20	interleukin 10	Mus musculus	229-234
27702566-5	2017	Microarray and qRT-PCR analysis of human hair follicles after Nrf2 activation using sulforaphane identified the modulation of phase II metabolism, reactive oxygen species clearance, the pentose phosphate pathway, and glutathione homeostasis.	sulforaphane	84-96	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
27979663-0	2017	Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.	sulforaphane	0-12	dendrocyte expressed seven transmembrane protein	Mus musculus	95-103
27979663-0	2017	Sulforaphane inhibits osteoclast differentiation by suppressing the cell-cell fusion molecules DC-STAMP and OC-STAMP.	sulforaphane	0-12	osteoclast stimulatory transmembrane protein	Mus musculus	108-116
28249909-6	2017	Data mining of the National Library of Medicine"s MEDLINE Database and Ingenuity Pathway analysis revealed agents of relatively low toxicity-melatonin, metformin, curcumin and sulforaphane-that are capable of inhibiting directly or pharmacogenomically one or both of the SIRT1 and EZH2 pathways and should, in a combinatorial fashion, remove the block in differentiation and decrease the proliferation of the B-cell ALL lymphoblasts.	sulforaphane	176-188	sirtuin 1	Homo sapiens	271-276
28249909-6	2017	Data mining of the National Library of Medicine"s MEDLINE Database and Ingenuity Pathway analysis revealed agents of relatively low toxicity-melatonin, metformin, curcumin and sulforaphane-that are capable of inhibiting directly or pharmacogenomically one or both of the SIRT1 and EZH2 pathways and should, in a combinatorial fashion, remove the block in differentiation and decrease the proliferation of the B-cell ALL lymphoblasts.	sulforaphane	176-188	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	281-285
28830206-3	2017	In this study, we examined the effects of SFN on HMGB1-mediated septic responses and survival rate in a mouse sepsis model.	sulforaphane	42-45	high mobility group box 1	Mus musculus	49-54
27281367-7	2017	This article focuses on plant-derived HDAC inhibitor Sulforaphane (SFN) as a promising antipancreatic cancer agent.	sulforaphane	53-65	histone deacetylase 9	Homo sapiens	38-42
27281367-7	2017	This article focuses on plant-derived HDAC inhibitor Sulforaphane (SFN) as a promising antipancreatic cancer agent.	sulforaphane	67-70	histone deacetylase 9	Homo sapiens	38-42
28830206-4	2017	The anti-inflammatory activities of SFN were monitored based on its effects on lipopolysaccharide (LPS)- or cecal ligation and puncture (CLP)-mediated release of HMGB1.	sulforaphane	36-39	high mobility group box 1	Mus musculus	162-167
29619410-5	2017	In this article, we list SFN contents in common cruciferous vegetables, and summarize recent advances in the protective effects of SFN against acute brain injuries and neurodegenerative diseases through activating Nrf2 signaling pathway.	sulforaphane	131-134	NFE2 like bZIP transcription factor 2	Homo sapiens	214-218
28830206-7	2017	SFN also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in mice.	sulforaphane	0-3	high mobility group box 1	Mus musculus	19-24
28830206-8	2017	In addition, treatment with SFN reduced CLP-induced release of HMGB1 and sepsis-related mortality and pulmonary injury in vivo.	sulforaphane	28-31	high mobility group box 1	Mus musculus	63-68
28830206-9	2017	Our results indicate that SFN is a possible therapeutic agent that can be used to treat various severe vascular inflammatory diseases via the inhibition of the HMGB1 signaling pathway.	sulforaphane	26-29	high mobility group box 1	Mus musculus	160-165
26833863-9	2017	We also used cDNA microarray to confirm several gene expressions such as caspase -8, -3, -4, -6, and -7 that are affected by SFN.	sulforaphane	125-128	caspase 8	Homo sapiens	73-103
27079867-4	2017	The rationale for investigating Nrf2 status was based upon recent reports showing that certain compounds (sulforaphane and linalool) suppress LPS-induced inflammation in an Nrf2-dependent manner.	sulforaphane	106-118	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
27079867-4	2017	The rationale for investigating Nrf2 status was based upon recent reports showing that certain compounds (sulforaphane and linalool) suppress LPS-induced inflammation in an Nrf2-dependent manner.	sulforaphane	106-118	nuclear factor, erythroid derived 2, like 2	Mus musculus	173-177
29224018-1	2017	BACKGROUND/AIMS: To explore the effect of sulforaphane (SFN) treatment in rats through the induction of Stress Urinary Incontinence (SUI) via the Nrf2-ARE pathway.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150
29224018-1	2017	BACKGROUND/AIMS: To explore the effect of sulforaphane (SFN) treatment in rats through the induction of Stress Urinary Incontinence (SUI) via the Nrf2-ARE pathway.	sulforaphane	56-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150
27833054-2	2017	Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-121
26879838-0	2017	Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction.	sulforaphane	0-12	microRNA 200c	Homo sapiens	106-114
26879838-4	2017	ALDH1 activity and CD44 positivity of OSCC-CSCs with sulforaphane treatment was assessed by flow cytometry analysis.	sulforaphane	53-65	CD44 molecule (Indian blood group)	Homo sapiens	19-23
26879838-7	2017	Cancer stemness properties including self-renewal, CD44 positivity, and ALDH1 activity were also decreased in OSCC-CSCs with different doses of sulforaphane treatment.	sulforaphane	144-156	CD44 molecule (Indian blood group)	Homo sapiens	51-55
26879838-7	2017	Cancer stemness properties including self-renewal, CD44 positivity, and ALDH1 activity were also decreased in OSCC-CSCs with different doses of sulforaphane treatment.	sulforaphane	144-156	aldehyde dehydrogenase 1 family member A1	Homo sapiens	72-77
26879838-9	2017	Sulforaphane treatment resulted in a dose-dependent increase in the levels of tumor suppressive miR200c.	sulforaphane	0-12	microRNA 200c	Homo sapiens	96-103
27833054-2	2017	Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
27833054-2	2017	Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-121
27833054-2	2017	Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
27833054-4	2017	Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor-alpha (TNF-alpha) level and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg).	sulforaphane	18-21	tumor necrosis factor	Mus musculus	69-96
27833054-4	2017	Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor-alpha (TNF-alpha) level and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg).	sulforaphane	18-21	tumor necrosis factor	Mus musculus	98-107
27833054-7	2017	In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions.	sulforaphane	13-16	brain derived neurotrophic factor	Mus musculus	111-144
29040973-9	2017	CONCLUSION: The findings suggest beneficial effects of dietary bioactive compounds such as SFN and EGCG and their effect on BC cells by restoring estrogen receptor gene expression, modulating epigenetic changes and events, and interfering with tumor growth rate.	sulforaphane	91-94	estrogen receptor 1	Homo sapiens	146-163
27833054-7	2017	In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions.	sulforaphane	13-16	discs large MAGUK scaffold protein 4	Mus musculus	146-177
27833054-7	2017	In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions.	sulforaphane	13-16	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	199-204
26742517-0	2017	Sulforaphane Prevents Methylmercury-Induced Oxidative Damage and Excitotoxicity Through Activation of the Nrf2-ARE Pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
26742517-10	2017	Furthermore, the present study also indicated that SFN pretreatment significantly reinforced the activation of the Nrf2-ARE pathway, which could prevent the toxic effects of MeHg exposure.	sulforaphane	51-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
26742517-11	2017	Collectively, MeHg initiates multiple additive or synergistic disruptive mechanisms that lead to oxidative damage and excitotoxicity in rat cerebral cortex; pretreatment with SFN might prevent the MeHg-induced neurotoxicity by reinforcing the activation of the Nrf2-ARE pathway and then downregulating the interaction between oxidative damage and excitotoxicity pathways.	sulforaphane	175-178	NFE2 like bZIP transcription factor 2	Rattus norvegicus	261-265
28191275-0	2017	Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2.	sulforaphane	0-12	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	22-36
27959410-9	2017	Treatment with SFN for 48 h also significantly upregulated the protein expression levels of Bip/GRP78, XBP-1, caspase-12, CHOP/GADD153 and Bid in HepG2 cells.	sulforaphane	15-18	heat shock protein family A (Hsp70) member 5	Homo sapiens	92-95
27959410-9	2017	Treatment with SFN for 48 h also significantly upregulated the protein expression levels of Bip/GRP78, XBP-1, caspase-12, CHOP/GADD153 and Bid in HepG2 cells.	sulforaphane	15-18	heat shock protein family A (Hsp70) member 5	Homo sapiens	96-101
27959410-9	2017	Treatment with SFN for 48 h also significantly upregulated the protein expression levels of Bip/GRP78, XBP-1, caspase-12, CHOP/GADD153 and Bid in HepG2 cells.	sulforaphane	15-18	X-box binding protein 1	Homo sapiens	103-108
27959410-9	2017	Treatment with SFN for 48 h also significantly upregulated the protein expression levels of Bip/GRP78, XBP-1, caspase-12, CHOP/GADD153 and Bid in HepG2 cells.	sulforaphane	15-18	DNA damage inducible transcript 3	Homo sapiens	122-126
27959410-9	2017	Treatment with SFN for 48 h also significantly upregulated the protein expression levels of Bip/GRP78, XBP-1, caspase-12, CHOP/GADD153 and Bid in HepG2 cells.	sulforaphane	15-18	DNA damage inducible transcript 3	Homo sapiens	127-134
27959410-9	2017	Treatment with SFN for 48 h also significantly upregulated the protein expression levels of Bip/GRP78, XBP-1, caspase-12, CHOP/GADD153 and Bid in HepG2 cells.	sulforaphane	15-18	BH3 interacting domain death agonist	Homo sapiens	139-142
28191275-0	2017	Sulforaphane Prevents Angiotensin II-Induced Testicular Cell Death via Activation of NRF2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
28191275-3	2017	Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling.	sulforaphane	149-161	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232
28191275-3	2017	Therefore, the present study aims to determine whether Ang II can induce testicular apoptotic cell death and whether this action can be prevented by sulforaphane (SFN) via activating nuclear factor (erythroid-derived 2)-like 2 (NRF2), the governor of antioxidant-redox signalling.	sulforaphane	163-166	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232
28191275-6	2017	Deletion of the Nrf2 gene led to a complete abolishment of these efficacies of SFN.	sulforaphane	79-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
28386307-2	2017	This study aimed to determine the protective effects of sulforaphane, a natural isothiocyanate Nrf2-inducer, against cholesterol-induced pancreatic beta-cells dysfunction, through molecular and cellular mechanisms involving mitochondrial bioenergetics.	sulforaphane	56-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
28191275-7	2017	The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.	sulforaphane	113-116	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	33-39
28386307-4	2017	Sulforaphane also attenuated the cholesterol-induced activation of the NFkappaB pathway, normalizing the expression of pro- and anti-inflammatory cytokines.	sulforaphane	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-79
28386307-6	2017	Sulforaphane increased the expression of antioxidant enzymes downstream of the Nrf2 pathway and prevented lipid peroxidation induced by cholesterol.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
28191275-7	2017	The present study indicated that Ang II may result in testicular apoptotic cell death, which can be prevented by SFN via the activation of NRF2.	sulforaphane	113-116	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
28607561-4	2017	METHODS: Stable knockdown of Nrf2 and Keap1 was achieved by transduction with lentiviral shRNAs; activation of Nrf2 was induced by incubation with sulforaphane (SFN).	sulforaphane	147-159	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
28607561-4	2017	METHODS: Stable knockdown of Nrf2 and Keap1 was achieved by transduction with lentiviral shRNAs; activation of Nrf2 was induced by incubation with sulforaphane (SFN).	sulforaphane	161-164	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
27693416-0	2016	Sulforaphane activates the cerebral vascular Nrf2-ARE pathway and suppresses inflammation to attenuate cerebral vasospasm in rat with subarachnoid hemorrhage.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	45-49
27982105-8	2016	In vitro, sulforaphane treatment attenuated TGF-beta1-induced EMT, accompanied by the down-regulation of snail.	sulforaphane	10-22	transforming growth factor, beta 1	Mus musculus	44-53
27982105-8	2016	In vitro, sulforaphane treatment attenuated TGF-beta1-induced EMT, accompanied by the down-regulation of snail.	sulforaphane	10-22	snail family zinc finger 1	Mus musculus	105-110
27863441-5	2016	SFN induced a marked decrease in the cell cycle activating proteins cdk1 and cyclin B and siRNA knock-down of cdk1 and cyclin B resulted in significantly diminished RCC cell growth.	sulforaphane	0-3	cyclin dependent kinase 1	Homo sapiens	68-72
27693416-4	2016	We investigated whether the administration of sulforaphane (SFN, a specific Nrf2 activator) modulated vascular caliber, Nrf2-ARE pathway activity, proinflammatory cytokine expression, and clinical behavior in a rat model of SAH.	sulforaphane	46-58	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
27693416-4	2016	We investigated whether the administration of sulforaphane (SFN, a specific Nrf2 activator) modulated vascular caliber, Nrf2-ARE pathway activity, proinflammatory cytokine expression, and clinical behavior in a rat model of SAH.	sulforaphane	60-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
27778243-6	2016	Sulforaphane, a Nrf2 activator, was administered to NTG-induced rats.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	16-20
27629595-5	2016	Migration assays of RMS cells revealed that inhibitors of MIF (ISO-1, Ant.III 4-IPP, Ant.V, sulforaphane (SF)) and blocking antibodies caused reduced migration, indicating a role for MIF in metastatic invasion.	sulforaphane	106-108	macrophage migration inhibitory factor	Homo sapiens	58-61
27778243-10	2016	Sulforaphane pretreatment significantly increased the nuclear Nrf2, HO1, and NQO1 levels in TNC.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
27778243-10	2016	Sulforaphane pretreatment significantly increased the nuclear Nrf2, HO1, and NQO1 levels in TNC.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	68-71
27778243-10	2016	Sulforaphane pretreatment significantly increased the nuclear Nrf2, HO1, and NQO1 levels in TNC.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	77-81
27778243-11	2016	In addition, sulforaphane exposure effectively inhibited the expression of nNOS and c-Fos, reduced the number of nNOS and c-Fos immunoreactive neurons in TNC, and attenuated the tactile thresholds induced by NTG injection.	sulforaphane	13-25	nitric oxide synthase 1	Rattus norvegicus	75-79
27778243-11	2016	In addition, sulforaphane exposure effectively inhibited the expression of nNOS and c-Fos, reduced the number of nNOS and c-Fos immunoreactive neurons in TNC, and attenuated the tactile thresholds induced by NTG injection.	sulforaphane	13-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-89
27779894-0	2016	Influence of Sulforaphane Metabolites on Activities of Human Drug-Metabolizing Cytochrome P450 and Determination of Sulforaphane in Human Liver Cells.	sulforaphane	13-25	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-94
27778243-11	2016	In addition, sulforaphane exposure effectively inhibited the expression of nNOS and c-Fos, reduced the number of nNOS and c-Fos immunoreactive neurons in TNC, and attenuated the tactile thresholds induced by NTG injection.	sulforaphane	13-25	nitric oxide synthase 1	Rattus norvegicus	113-117
27778243-11	2016	In addition, sulforaphane exposure effectively inhibited the expression of nNOS and c-Fos, reduced the number of nNOS and c-Fos immunoreactive neurons in TNC, and attenuated the tactile thresholds induced by NTG injection.	sulforaphane	13-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	122-127
27832073-2	2016	Sulforaphane has been shown to induce expression of antioxidant genes via activation of a transcription factor, nuclear factor erythroid-2 related factor 2 (Nrf2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	112-155
26693692-0	2016	The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane.	sulforaphane	125-137	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	4-8
26693692-5	2016	Moreover, the diet-derived cancer prevention agent, sulforaphane (SFN), suppresses MCS cell survival and this is associated with loss of Ezh2.	sulforaphane	52-64	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	137-141
26693692-5	2016	Moreover, the diet-derived cancer prevention agent, sulforaphane (SFN), suppresses MCS cell survival and this is associated with loss of Ezh2.	sulforaphane	66-69	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	137-141
26693692-7	2016	A375 melanoma cell-derived MCS cells form rapidly growing tumors in immune-compromised mice and SFN treatment of these tumors reduces tumor growth and this is associated with reduced Ezh2 level and H3K27me3 formation, reduced matrix metalloproteinase expression, increased TIMP3 expression and increased apoptosis.	sulforaphane	96-99	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	183-187
26693692-7	2016	A375 melanoma cell-derived MCS cells form rapidly growing tumors in immune-compromised mice and SFN treatment of these tumors reduces tumor growth and this is associated with reduced Ezh2 level and H3K27me3 formation, reduced matrix metalloproteinase expression, increased TIMP3 expression and increased apoptosis.	sulforaphane	96-99	tissue inhibitor of metalloproteinase 3	Mus musculus	273-278
27832073-2	2016	Sulforaphane has been shown to induce expression of antioxidant genes via activation of a transcription factor, nuclear factor erythroid-2 related factor 2 (Nrf2).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
26990292-3	2016	Interestingly, the expression of c-Myc, an oncogenic transcription factor that is frequently deregulated in prostate cancer cells, was markedly suppressed by SFN both in vitro and in vivo.	sulforaphane	158-161	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	33-38
27824145-0	2016	Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis.	sulforaphane	0-12	interleukin 6 receptor	Homo sapiens	106-111
27824145-0	2016	Sulforaphane improves chemotherapy efficacy by targeting cancer stem cell-like properties via the miR-124/IL-6R/STAT3 axis.	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	112-117
27681094-0	2016	Inhibition of STAT3 phosphorylation by sulforaphane reduces adhesion molecule expression in vascular endothelial cell.	sulforaphane	39-51	signal transducer and activator of transcription 3	Homo sapiens	14-19
27681094-2	2016	In this study, we explored whether sulforaphane, a dietary phytochemical, can inhibit the expression of ICAM-1 and VCAM-1 in human umbilical vein endothelial cells (HUVEC) stimulated with lipopolysaccharide (LPS), and the mechanisms involved.	sulforaphane	35-47	intercellular adhesion molecule 1	Homo sapiens	104-110
27681094-2	2016	In this study, we explored whether sulforaphane, a dietary phytochemical, can inhibit the expression of ICAM-1 and VCAM-1 in human umbilical vein endothelial cells (HUVEC) stimulated with lipopolysaccharide (LPS), and the mechanisms involved.	sulforaphane	35-47	vascular cell adhesion molecule 1	Homo sapiens	115-121
27681094-3	2016	Sulforaphane prevented the LPS-mediated increase in ICAM-1 and VCAM-1 expression, (P < 0.01) in HUVEC.	sulforaphane	0-12	intercellular adhesion molecule 1	Homo sapiens	52-58
27681094-3	2016	Sulforaphane prevented the LPS-mediated increase in ICAM-1 and VCAM-1 expression, (P < 0.01) in HUVEC.	sulforaphane	0-12	vascular cell adhesion molecule 1	Homo sapiens	63-69
27681094-4	2016	Sulforaphane also prevented the LPS-mediated increase in the phosphorylation of signal transducer and activator of transcription 3 (STAT3) (P < 0.01).	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	80-130
27681094-4	2016	Sulforaphane also prevented the LPS-mediated increase in the phosphorylation of signal transducer and activator of transcription 3 (STAT3) (P < 0.01).	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	132-137
27681094-7	2016	Sulforaphane reduced LPS-mediated THP-1 monocyte adhesion to HUVEC (P < 0.01).	sulforaphane	0-12	GLI family zinc finger 2	Homo sapiens	34-39
27681094-8	2016	In C57BL/6 mice, injection of LPS increased aortic ICAM-1 and VCAM-1 expression, and this effect was prevented by sulforaphane.	sulforaphane	114-126	intercellular adhesion molecule 1	Mus musculus	51-57
27681094-8	2016	In C57BL/6 mice, injection of LPS increased aortic ICAM-1 and VCAM-1 expression, and this effect was prevented by sulforaphane.	sulforaphane	114-126	vascular cell adhesion molecule 1	Mus musculus	62-68
27681094-9	2016	These data provide insight into the mechanism through which sulforaphane partly reduces the expression of ICAM-1 and VCAM-1 on the vascular wall by inhibiting STAT3 phosphorylation.	sulforaphane	60-72	intercellular adhesion molecule 1	Homo sapiens	106-112
27681094-9	2016	These data provide insight into the mechanism through which sulforaphane partly reduces the expression of ICAM-1 and VCAM-1 on the vascular wall by inhibiting STAT3 phosphorylation.	sulforaphane	60-72	vascular cell adhesion molecule 1	Homo sapiens	117-123
27681094-9	2016	These data provide insight into the mechanism through which sulforaphane partly reduces the expression of ICAM-1 and VCAM-1 on the vascular wall by inhibiting STAT3 phosphorylation.	sulforaphane	60-72	signal transducer and activator of transcription 3	Homo sapiens	159-164
27693327-5	2016	At the same time, the activation of Nrf2 with D, l-sulforaphane (SFN) and CDDO-Me could repress the replication of SVCV, and knockdown of Nrf2 by siRNA could promote the replication of SVCV.	sulforaphane	65-68	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
27688705-7	2016	LPS-induced TRAM, TRIF, RIPK1, TRAF3, TNF-alpha, IL-1beta and IFN-beta were suppressed by 5 microM SFN.	sulforaphane	99-102	receptor interacting serine/threonine kinase 1	Sus scrofa	24-29
27688705-7	2016	LPS-induced TRAM, TRIF, RIPK1, TRAF3, TNF-alpha, IL-1beta and IFN-beta were suppressed by 5 microM SFN.	sulforaphane	99-102	TNF receptor associated factor 3	Sus scrofa	31-36
27688705-7	2016	LPS-induced TRAM, TRIF, RIPK1, TRAF3, TNF-alpha, IL-1beta and IFN-beta were suppressed by 5 microM SFN.	sulforaphane	99-102	tumor necrosis factor	Sus scrofa	38-47
27688705-7	2016	LPS-induced TRAM, TRIF, RIPK1, TRAF3, TNF-alpha, IL-1beta and IFN-beta were suppressed by 5 microM SFN.	sulforaphane	99-102	interleukin-1 beta	Sus scrofa	49-57
27688705-7	2016	LPS-induced TRAM, TRIF, RIPK1, TRAF3, TNF-alpha, IL-1beta and IFN-beta were suppressed by 5 microM SFN.	sulforaphane	99-102	interferon beta 1	Sus scrofa	62-70
26990292-0	2016	Sulforaphane Inhibits c-Myc-Mediated Prostate Cancer Stem-Like Traits.	sulforaphane	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
26990292-2	2016	Here, we show that the prostate cancer stem cell (pCSC)-like traits, such as accelerated activity of aldehyde dehydrogenase 1 (ALDH1), enrichment of CD49f+ fraction, and sphere forming efficiency, are attenuated by SFN treatment.	sulforaphane	215-218	aldehyde dehydrogenase 1 family member A1	Homo sapiens	101-125
27636860-0	2016	Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	23-29
27636860-6	2016	SFN induced Nrf2 target enzyme activity in HT-29 and Caco-2 cancer cells but regulated the Nrf2/ARE signaling pathway differently in cancer and untransformed cells.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	12-16
27636860-6	2016	SFN induced Nrf2 target enzyme activity in HT-29 and Caco-2 cancer cells but regulated the Nrf2/ARE signaling pathway differently in cancer and untransformed cells.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
27567738-3	2016	Sulforaphane (SF) protects cells from oxidative damage through nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is responsible for multiple detoxification processes, including elevating the expression of Trx.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	63-106
27567738-3	2016	Sulforaphane (SF) protects cells from oxidative damage through nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is responsible for multiple detoxification processes, including elevating the expression of Trx.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
27567738-3	2016	Sulforaphane (SF) protects cells from oxidative damage through nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is responsible for multiple detoxification processes, including elevating the expression of Trx.	sulforaphane	0-12	thioredoxin	Homo sapiens	213-216
27567738-3	2016	Sulforaphane (SF) protects cells from oxidative damage through nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is responsible for multiple detoxification processes, including elevating the expression of Trx.	sulforaphane	14-16	NFE2 like bZIP transcription factor 2	Homo sapiens	63-106
27567738-3	2016	Sulforaphane (SF) protects cells from oxidative damage through nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is responsible for multiple detoxification processes, including elevating the expression of Trx.	sulforaphane	14-16	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
27567738-3	2016	Sulforaphane (SF) protects cells from oxidative damage through nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which is responsible for multiple detoxification processes, including elevating the expression of Trx.	sulforaphane	14-16	thioredoxin	Homo sapiens	213-216
27636860-0	2016	Sulforaphane Regulates NFE2L2/Nrf2-Dependent Xenobiotic Metabolism Phase II and Phase III Enzymes Differently in Human Colorectal Cancer and Untransformed Epithelial Colon Cells.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
27636860-1	2016	Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is a nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	85-119
27636860-1	2016	Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is a nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	121-127
27636860-1	2016	Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is a nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
27636860-1	2016	Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is a nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	85-119
27636860-1	2016	Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is a nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	121-127
27636860-1	2016	Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is a nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
27636860-4	2016	The aim of this study was to compare the effect of SFN on the Nrf2 system and the Nrf2-target enzymes NQO1 and MRP in human untransformed epithelial colon CRL-1790 cells and in HT-29 and Caco-2 colorectal cancer cells to elucidate the role of SFN in cancer prevention and treatment.	sulforaphane	51-54	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
27727176-0	2016	Sulforaphane Prevents Testicular Damage in Kunming Mice Exposed to Cadmium via Activation of Nrf2/ARE Signaling Pathways.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
27736946-5	2016	Here we found that RA-SFs treated with the HDAC inhibitor Trichostatin A (TSA) exhibited an upregulation of the immediate early response gene X-1 (IEX-1).	sulforaphane	22-25	immediate early response 3	Homo sapiens	147-152
27727176-10	2016	Sulforaphane prevents cadmium-induced testicular damage, probably via activation of Nrf2/ARE signaling.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
27499349-11	2016	Pre-exposure to SFN also reduced R1881-stimulated nuclear localization of AR, and combined treatment with SFN and anti-androgens abrogated the mitogenic effects of this AR-agonist (p<0.005).	sulforaphane	106-109	androgen receptor	Homo sapiens	169-171
27499349-0	2016	Sulforaphane increases the efficacy of anti-androgens by rapidly decreasing androgen receptor levels in prostate cancer cells.	sulforaphane	0-12	androgen receptor	Homo sapiens	76-93
27499349-5	2016	Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, can decrease AR protein levels.	sulforaphane	0-12	androgen receptor	Homo sapiens	103-105
27499349-5	2016	Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, can decrease AR protein levels.	sulforaphane	14-17	androgen receptor	Homo sapiens	103-105
27499349-10	2016	This rapid and potent AR suppression by SFN occurred by both AR protein degradation, as suggested by cycloheximide (CHX) co-exposure studies, and by suppression of AR gene expression, as evident from quantitative RT-PCR experiments.	sulforaphane	40-43	androgen receptor	Homo sapiens	22-24
27427974-5	2016	Twelve of these sequences were validated as NFE2L2 regulated AREs in 9 autophagy genes by additional ChIP assays and quantitative RT-PCR on human and mouse cells after NFE2L2 activation with sulforaphane.	sulforaphane	191-203	NFE2 like bZIP transcription factor 2	Homo sapiens	44-50
27427974-5	2016	Twelve of these sequences were validated as NFE2L2 regulated AREs in 9 autophagy genes by additional ChIP assays and quantitative RT-PCR on human and mouse cells after NFE2L2 activation with sulforaphane.	sulforaphane	191-203	nuclear factor, erythroid derived 2, like 2	Mus musculus	168-174
27401964-0	2016	Sulforaphane induces neurovascular protection against a systemic inflammatory challenge via both Nrf2-dependent and independent pathways.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
26433376-0	2016	Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-94
26433376-2	2016	Sulforaphane (dietary isothiocyanate compound), an activator of Nrf2 signaling, exhibits neuroprotective effects.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-68
26433376-9	2016	The protective effects of sulforaphane were abolished with Nrf2 siRNA and HO-1 inhibition in astrocytes.	sulforaphane	26-38	NFE2 like bZIP transcription factor 2	Rattus norvegicus	59-63
26433376-10	2016	The results suggest that Nrf2-dependent activation of cellular antioxidant machinery results in sulforaphane-mediated protection against OKA-induced memory impairment in rats.	sulforaphane	96-108	NFE2 like bZIP transcription factor 2	Rattus norvegicus	25-29
27499349-10	2016	This rapid and potent AR suppression by SFN occurred by both AR protein degradation, as suggested by cycloheximide (CHX) co-exposure studies, and by suppression of AR gene expression, as evident from quantitative RT-PCR experiments.	sulforaphane	40-43	androgen receptor	Homo sapiens	61-63
27499349-10	2016	This rapid and potent AR suppression by SFN occurred by both AR protein degradation, as suggested by cycloheximide (CHX) co-exposure studies, and by suppression of AR gene expression, as evident from quantitative RT-PCR experiments.	sulforaphane	40-43	androgen receptor	Homo sapiens	61-63
27499349-11	2016	Pre-exposure to SFN also reduced R1881-stimulated nuclear localization of AR, and combined treatment with SFN and anti-androgens abrogated the mitogenic effects of this AR-agonist (p<0.005).	sulforaphane	16-19	androgen receptor	Homo sapiens	74-76
27218607-3	2016	The goal was to investigate the putative effects of natural antioxidant sulforaphane (1-isothiocyanate-4-methyl-sulfonyl butane; SFN) on browning of white adipocytes.	sulforaphane	72-84	RNA exonuclease 2	Homo sapiens	129-132
27401964-6	2016	This protective effect of SFN was lost in Nrf2-KO mice at the lower dose tested, however 50mg/kg SFN revealed a partial effect, suggesting SFN works in part independently of Nrf2 activity.	sulforaphane	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
27528021-3	2016	Early response (6 hours) of A2780 ovarian carcinoma cells to SFN treatment involves generation of mitochondrial ROS and increased transcription of NRF2 and its downstream regulated genes including heme oxygenase 1, NAD(P)H:quinine oxidoreductase 1, and KLF9.	sulforaphane	61-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
27528021-5	2016	SFN induces a time-dependent phosphorylation wave of HSP27.	sulforaphane	0-3	heat shock protein 1	Mus musculus	53-58
27528021-1	2016	In this study we show that anti-tumor effect of sulforaphane (SFN) is partially realized through the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1).	sulforaphane	48-60	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	101-145
27528021-1	2016	In this study we show that anti-tumor effect of sulforaphane (SFN) is partially realized through the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1).	sulforaphane	48-60	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	147-152
27528021-6	2016	Use of IP3R inhibitor Xestospongin C (Xest) attenuates both SFN-induced apoptosis and the level of NRF2 protein expression.	sulforaphane	60-63	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	7-11
27528021-1	2016	In this study we show that anti-tumor effect of sulforaphane (SFN) is partially realized through the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1).	sulforaphane	62-65	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	101-145
27528021-1	2016	In this study we show that anti-tumor effect of sulforaphane (SFN) is partially realized through the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1).	sulforaphane	62-65	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	147-152
27528021-8	2016	SFN-induced apoptosis is completely inhibited by silencing of IP3R1 gene but only partially blocked by silencing of NRF2; silencing of IP3R2 and IP3R3 had no effect on these cells.	sulforaphane	0-3	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	62-67
27528021-8	2016	SFN-induced apoptosis is completely inhibited by silencing of IP3R1 gene but only partially blocked by silencing of NRF2; silencing of IP3R2 and IP3R3 had no effect on these cells.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
27528021-8	2016	SFN-induced apoptosis is completely inhibited by silencing of IP3R1 gene but only partially blocked by silencing of NRF2; silencing of IP3R2 and IP3R3 had no effect on these cells.	sulforaphane	0-3	inositol 1,4,5-triphosphate receptor 2	Mus musculus	135-140
27528021-8	2016	SFN-induced apoptosis is completely inhibited by silencing of IP3R1 gene but only partially blocked by silencing of NRF2; silencing of IP3R2 and IP3R3 had no effect on these cells.	sulforaphane	0-3	inositol 1,4,5-triphosphate receptor 3	Mus musculus	145-150
27528021-11	2016	In addition, immunofluorescent staining with IP3R1 antibody revealed that SFN treatment induces translocation of IP3R1 to the nucleus.	sulforaphane	74-77	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	45-50
27528021-11	2016	In addition, immunofluorescent staining with IP3R1 antibody revealed that SFN treatment induces translocation of IP3R1 to the nucleus.	sulforaphane	74-77	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	113-118
27528021-12	2016	Our results clearly show that IP3R1 is involved in SFN-induced apoptosis through the depletion of reticular calcium and modulation of transcription factors through nuclear calcium up-regulation.	sulforaphane	51-54	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	30-35
27625902-0	2015	Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane.	sulforaphane	84-96	NAD(P)H quinone dehydrogenase 1	Homo sapiens	14-18
27625902-0	2015	Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane.	sulforaphane	84-96	NAD(P)H quinone dehydrogenase 1	Homo sapiens	22-26
27626412-0	2016	Sulforaphane, a Dietary Isothiocyanate, Induces G2/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45beta/CDC2 Association.	sulforaphane	0-12	cyclin B1	Homo sapiens	93-101
27625902-5	2015	Whether NQO1 expression/activity in leukemia cells that carry the labile NQO1*2 genotype can be induced by broccoli-derived phytochemical sulforaphane (SFN) is currently unknown.	sulforaphane	138-150	NAD(P)H quinone dehydrogenase 1	Homo sapiens	8-12
27625902-5	2015	Whether NQO1 expression/activity in leukemia cells that carry the labile NQO1*2 genotype can be induced by broccoli-derived phytochemical sulforaphane (SFN) is currently unknown.	sulforaphane	138-150	NAD(P)H quinone dehydrogenase 1	Homo sapiens	73-77
27625902-5	2015	Whether NQO1 expression/activity in leukemia cells that carry the labile NQO1*2 genotype can be induced by broccoli-derived phytochemical sulforaphane (SFN) is currently unknown.	sulforaphane	152-155	NAD(P)H quinone dehydrogenase 1	Homo sapiens	8-12
27625902-8	2015	A dose-dependent increase in NQO1 level/activity is accompanied by upregulation of the transcription factor, Nrf2, following 1-10 muM SFN treatment.	sulforaphane	134-137	NAD(P)H quinone dehydrogenase 1	Homo sapiens	29-33
27625902-8	2015	A dose-dependent increase in NQO1 level/activity is accompanied by upregulation of the transcription factor, Nrf2, following 1-10 muM SFN treatment.	sulforaphane	134-137	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
27625902-8	2015	A dose-dependent increase in NQO1 level/activity is accompanied by upregulation of the transcription factor, Nrf2, following 1-10 muM SFN treatment.	sulforaphane	134-137	latexin	Homo sapiens	130-133
27625902-9	2015	Treatment with 25 microM SFN drastically reduced NQO1 levels, inhibited cell proliferation, caused sub-G1 cell arrest, and induced apoptosis, and a decrease in the levels of the transcription factor, nuclear factor-kappaB (NFkappaB).	sulforaphane	25-28	NAD(P)H quinone dehydrogenase 1	Homo sapiens	49-53
27625902-9	2015	Treatment with 25 microM SFN drastically reduced NQO1 levels, inhibited cell proliferation, caused sub-G1 cell arrest, and induced apoptosis, and a decrease in the levels of the transcription factor, nuclear factor-kappaB (NFkappaB).	sulforaphane	25-28	nuclear factor kappa B subunit 1	Homo sapiens	200-221
27625902-9	2015	Treatment with 25 microM SFN drastically reduced NQO1 levels, inhibited cell proliferation, caused sub-G1 cell arrest, and induced apoptosis, and a decrease in the levels of the transcription factor, nuclear factor-kappaB (NFkappaB).	sulforaphane	25-28	nuclear factor kappa B subunit 1	Homo sapiens	223-231
27625902-10	2015	CONCLUSIONS: Up to 10 muM of SFN increases NQO1 expression and suppresses HL-60 cell proliferation whereas >= 25 muM of SFN induces apoptosis in HL-60 cells.	sulforaphane	29-32	latexin	Homo sapiens	22-25
27625902-10	2015	CONCLUSIONS: Up to 10 muM of SFN increases NQO1 expression and suppresses HL-60 cell proliferation whereas >= 25 muM of SFN induces apoptosis in HL-60 cells.	sulforaphane	29-32	NAD(P)H quinone dehydrogenase 1	Homo sapiens	43-47
27625902-10	2015	CONCLUSIONS: Up to 10 muM of SFN increases NQO1 expression and suppresses HL-60 cell proliferation whereas >= 25 muM of SFN induces apoptosis in HL-60 cells.	sulforaphane	123-126	latexin	Homo sapiens	116-119
27626412-0	2016	Sulforaphane, a Dietary Isothiocyanate, Induces G2/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45beta/CDC2 Association.	sulforaphane	0-12	growth arrest and DNA damage inducible beta	Homo sapiens	121-131
27626412-0	2016	Sulforaphane, a Dietary Isothiocyanate, Induces G2/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45beta/CDC2 Association.	sulforaphane	0-12	cyclin dependent kinase 1	Homo sapiens	132-136
27626412-7	2016	In addition, the effects of GADD45beta gene activation in cell cycle arrest increase proportionally with the dose of SFN; however, mitotic delay and the inhibition of proliferation both depend on the dosage of SFN used to treat cancer cells.	sulforaphane	117-120	growth arrest and DNA damage inducible beta	Homo sapiens	28-38
27626412-7	2016	In addition, the effects of GADD45beta gene activation in cell cycle arrest increase proportionally with the dose of SFN; however, mitotic delay and the inhibition of proliferation both depend on the dosage of SFN used to treat cancer cells.	sulforaphane	210-213	growth arrest and DNA damage inducible beta	Homo sapiens	28-38
27618111-3	2016	Here, we investigated the efficacy of sulforaphane (SFN), monomethyl fumarate (MMF) and Protandim to induce Nrf2-regulated antioxidant enzyme expression, and protect oligodendrocytes against ROS-induced cell death and ROS-and TNF-mediated inhibition of OPC differentiation.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
27618111-3	2016	Here, we investigated the efficacy of sulforaphane (SFN), monomethyl fumarate (MMF) and Protandim to induce Nrf2-regulated antioxidant enzyme expression, and protect oligodendrocytes against ROS-induced cell death and ROS-and TNF-mediated inhibition of OPC differentiation.	sulforaphane	38-50	tumor necrosis factor	Rattus norvegicus	226-229
27618111-3	2016	Here, we investigated the efficacy of sulforaphane (SFN), monomethyl fumarate (MMF) and Protandim to induce Nrf2-regulated antioxidant enzyme expression, and protect oligodendrocytes against ROS-induced cell death and ROS-and TNF-mediated inhibition of OPC differentiation.	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	advanced glycosylation end product-specific receptor	Rattus norvegicus	93-97
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	C-C motif chemokine ligand 2	Rattus norvegicus	99-133
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	C-C motif chemokine ligand 2	Rattus norvegicus	135-140
27430422-0	2016	Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells.	sulforaphane	0-12	galectin 1	Homo sapiens	64-74
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	intercellular adhesion molecule 1	Rattus norvegicus	143-176
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	intercellular adhesion molecule 1	Rattus norvegicus	178-184
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	vascular cell adhesion molecule 1	Rattus norvegicus	191-225
27212619-6	2016	Sulforaphane treatment for 4 or 24 h dose-dependently inhibited the AGEs-induced increase in RAGE, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecular-1 (VCAM-1) gene expression in HUVECs.	sulforaphane	0-12	vascular cell adhesion molecule 1	Rattus norvegicus	227-233
27212619-7	2016	AGEs significantly stimulated MCP-1 production by, and THP-1 cell adhesion to, HUVECs, both of which were prevented by 1.6 muM sulforaphane.	sulforaphane	127-139	chemokine (C-C motif) ligand 2	Mus musculus	30-35
27212619-9	2016	Furthermore, aortic RAGE, ICAM-1 and VCAM-1 expression in AGEs-injected rats were increased, which were suppressed by simultaneous infusion of sulforaphane.	sulforaphane	143-155	advanced glycosylation end product-specific receptor	Rattus norvegicus	20-24
27212619-9	2016	Furthermore, aortic RAGE, ICAM-1 and VCAM-1 expression in AGEs-injected rats were increased, which were suppressed by simultaneous infusion of sulforaphane.	sulforaphane	143-155	intercellular adhesion molecule 1	Rattus norvegicus	26-32
27212619-9	2016	Furthermore, aortic RAGE, ICAM-1 and VCAM-1 expression in AGEs-injected rats were increased, which were suppressed by simultaneous infusion of sulforaphane.	sulforaphane	143-155	vascular cell adhesion molecule 1	Rattus norvegicus	37-43
27212619-10	2016	CONCLUSION: The present study demonstrated for the first time that sulforaphane could inhibit inflammation in AGEs-exposed HUVECs and AGEs-infused rat aorta partly by suppressing RAGE expression through its anti-oxidative properties.	sulforaphane	67-79	advanced glycosylation end product-specific receptor	Rattus norvegicus	179-183
27212619-11	2016	Inhibition of the AGEs-RAGE axis by sulforaphane might be a novel therapeutic target for vascular injury in diabetes.	sulforaphane	36-48	advanced glycosylation end product-specific receptor	Rattus norvegicus	23-27
27553905-0	2016	Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.	sulforaphane	0-12	mechanistic target of rapamycin kinase	Homo sapiens	89-93
27553905-0	2016	Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2, and autophagy pathways.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
27553905-5	2016	Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes.	sulforaphane	39-51	NFE2 like bZIP transcription factor 2	Homo sapiens	80-123
27553905-5	2016	Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes.	sulforaphane	39-51	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
27553905-5	2016	Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes.	sulforaphane	39-51	heme oxygenase 1	Homo sapiens	132-148
27553905-5	2016	Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes.	sulforaphane	39-51	heme oxygenase 1	Homo sapiens	150-154
27553905-5	2016	Western blot analysis illustrated that sulforaphane increased the expression of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), heme oxygenase-1 (HO-1), and NAD(P)H quinone oxidoreductase (NQO1), the latter two of which are anti-oxidative enzymes.	sulforaphane	39-51	NAD(P)H quinone dehydrogenase 1	Homo sapiens	193-197
27553905-6	2016	Moreover, sulforaphane treatment significantly attenuated rotenone-inhibited mTOR-mediated p70S6K and 4E-BP1 signalling pathway, as well as neuronal apoptosis.	sulforaphane	10-22	mechanistic target of rapamycin kinase	Homo sapiens	77-81
27553905-6	2016	Moreover, sulforaphane treatment significantly attenuated rotenone-inhibited mTOR-mediated p70S6K and 4E-BP1 signalling pathway, as well as neuronal apoptosis.	sulforaphane	10-22	ribosomal protein S6 kinase B1	Homo sapiens	91-97
27553905-6	2016	Moreover, sulforaphane treatment significantly attenuated rotenone-inhibited mTOR-mediated p70S6K and 4E-BP1 signalling pathway, as well as neuronal apoptosis.	sulforaphane	10-22	BP1	Homo sapiens	105-108
27553905-8	2016	Collectively, these findings demonstrated that sulforaphane exert neuroprotective effect involving Nrf2-dependent reductions in oxidative stress, mTOR-dependent inhibition of neuronal apoptosis, and the restoration of normal autophagy.	sulforaphane	47-59	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
27553905-8	2016	Collectively, these findings demonstrated that sulforaphane exert neuroprotective effect involving Nrf2-dependent reductions in oxidative stress, mTOR-dependent inhibition of neuronal apoptosis, and the restoration of normal autophagy.	sulforaphane	47-59	mechanistic target of rapamycin kinase	Homo sapiens	146-150
27447968-8	2016	In a long-term chemoprevention study using wild-type and Nrf2-/- mice, we showed that topical application of SFN activated the NRF2 pathway, inhibited oxidative damage, and prevented 4NQO-induced oral carcinogenesis in an Nrf2-dependent manner.	sulforaphane	109-112	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
27447968-8	2016	In a long-term chemoprevention study using wild-type and Nrf2-/- mice, we showed that topical application of SFN activated the NRF2 pathway, inhibited oxidative damage, and prevented 4NQO-induced oral carcinogenesis in an Nrf2-dependent manner.	sulforaphane	109-112	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
27447968-0	2016	Chemoprevention of oxidative stress-associated oral carcinogenesis by sulforaphane depends on NRF2 and the isothiocyanate moiety.	sulforaphane	70-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
27447968-8	2016	In a long-term chemoprevention study using wild-type and Nrf2-/- mice, we showed that topical application of SFN activated the NRF2 pathway, inhibited oxidative damage, and prevented 4NQO-induced oral carcinogenesis in an Nrf2-dependent manner.	sulforaphane	109-112	nuclear factor, erythroid derived 2, like 2	Mus musculus	222-226
27447968-2	2016	In this study we aimed to examine whether a chemical activator of NRF2, sulforaphane (SFN), may have chemopreventive effects on oxidative stress-associated oral carcinogenesis.	sulforaphane	72-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
27447968-2	2016	In this study we aimed to examine whether a chemical activator of NRF2, sulforaphane (SFN), may have chemopreventive effects on oxidative stress-associated oral carcinogenesis.	sulforaphane	86-89	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
27447968-9	2016	Our data clearly demonstrate that SFN has chemopreventive effects on oxidative stress-associated oral carcinogenesis, and such effects depend on Nrf2 and the isothiocyanate moiety.	sulforaphane	34-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
27447968-6	2016	Using cultured human oral keratinocytes and 4NQO-treated mouse tongue, we found that SFN pre-treatment activated the NRF2 pathway and inhibited oxidative damage both in vitro and in vivo.	sulforaphane	85-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
27306194-6	2016	Furthermore, pre-treatment with sulforaphane, a well-known Nrf2 activator improved the survival of zebrafish larvae after arsenic exposure.	sulforaphane	32-44	nfe2 like bZIP transcription factor 2a	Danio rerio	59-63
27316684-5	2016	Deficiency of Nrf2 improved B. pseudomallei clearance by macrophages, whereas Nrf2 activation by sulforaphane and tert-butylhydroquinone with subsequent HO-1 induction enhanced intracellular bacterial growth.	sulforaphane	97-109	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
27478970-4	2016	RESULTS & CONCLUSION: Combined treatment with epigallocatechin-3-gallate in GTPs and sulforaphane in BSp resulted in a synergistic inhibition of breast cancer cellular growth.	sulforaphane	89-101	black spleen	Mus musculus	105-108
27460838-0	2016	Corrigendum to ""Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2"" [Free Radic.	sulforaphane	101-113	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
26456483-3	2016	Sulforaphane (SFN) induces nuclear factor erythroid 2-related factor 2 (Nrf2), which contributes to SFN-mediated protection against carcinogenesis.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-70
26456483-3	2016	Sulforaphane (SFN) induces nuclear factor erythroid 2-related factor 2 (Nrf2), which contributes to SFN-mediated protection against carcinogenesis.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
26456483-3	2016	Sulforaphane (SFN) induces nuclear factor erythroid 2-related factor 2 (Nrf2), which contributes to SFN-mediated protection against carcinogenesis.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-70
26456483-3	2016	Sulforaphane (SFN) induces nuclear factor erythroid 2-related factor 2 (Nrf2), which contributes to SFN-mediated protection against carcinogenesis.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
26456483-3	2016	Sulforaphane (SFN) induces nuclear factor erythroid 2-related factor 2 (Nrf2), which contributes to SFN-mediated protection against carcinogenesis.	sulforaphane	100-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-70
26456483-3	2016	Sulforaphane (SFN) induces nuclear factor erythroid 2-related factor 2 (Nrf2), which contributes to SFN-mediated protection against carcinogenesis.	sulforaphane	100-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
27478470-0	2016	Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	106-111
27478470-0	2016	Sulforaphane protects against acrolein-induced oxidative stress and inflammatory responses: modulation of Nrf-2 and COX-2 expression.	sulforaphane	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
27478470-9	2016	Pretreatment with sulforaphane enhanced the antioxidant status through upregulating Nrf-2 expression (p < 0.001) in PBMC.	sulforaphane	18-30	NFE2 like bZIP transcription factor 2	Homo sapiens	84-89
27423466-0	2016	Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	38-43
27423466-0	2016	Sulforaphane attenuates activation of NLRP3 and NLRC4 inflammasomes but not AIM2 inflammasome.	sulforaphane	0-12	NLR family, CARD domain containing 4	Mus musculus	48-53
27423466-8	2016	Thus, SFN is suggested as an anti-inflammasome molecule for NLRP3 and NLRC4 inflammasome activation.	sulforaphane	6-9	NLR family, pyrin domain containing 3	Mus musculus	60-65
27423466-8	2016	Thus, SFN is suggested as an anti-inflammasome molecule for NLRP3 and NLRC4 inflammasome activation.	sulforaphane	6-9	NLR family, CARD domain containing 4	Mus musculus	70-75
27300444-7	2016	Both hydrogen peroxide and sulforaphane pretreatment reduced ROS production, increased the expression of Nrf-2, and decreased the expression of Runx2 following calcification.	sulforaphane	27-39	NFE2 like bZIP transcription factor 2	Homo sapiens	105-110
27288935-8	2016	Moreover, sulforaphane stimulated the cytoprotective heme oxygenase-1 (HO-1) (38%).	sulforaphane	10-22	heme oxygenase 1	Rattus norvegicus	53-69
27288935-10	2016	In the MI+SFN group, up-regulation of ERK 1/2 (34%) and Akt (35%), as well as down-regulation of p38 (52%), was observed.	sulforaphane	10-13	mitogen activated protein kinase 3	Rattus norvegicus	38-45
27288935-10	2016	In the MI+SFN group, up-regulation of ERK 1/2 (34%) and Akt (35%), as well as down-regulation of p38 (52%), was observed.	sulforaphane	10-13	mitogen activated protein kinase 14	Rattus norvegicus	97-100
27300444-7	2016	Both hydrogen peroxide and sulforaphane pretreatment reduced ROS production, increased the expression of Nrf-2, and decreased the expression of Runx2 following calcification.	sulforaphane	27-39	RUNX family transcription factor 2	Homo sapiens	144-149
27035641-0	2016	The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line.	sulforaphane	14-26	cyclin D1	Homo sapiens	74-83
27135370-3	2016	Sulforaphane targets the PI3K-Akt pathway whose dysregulation is implicated in many functions of cancer cells.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	30-33
29337484-5	2016	SFN-loaded nanoparticles were more effective in inhibiting BCSCs than free SFN in vitro by down-regulating beta-catenin expression.	sulforaphane	0-3	catenin beta 1	Homo sapiens	107-119
27301376-10	2016	RESULTS: Nrf2 activators such as sulforaphane and DMF showed anti-inflammatory effects in HRMCs, whereas glucocorticoid (prednisolone) showed partial effects.	sulforaphane	33-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
27470577-6	2016	Pretreatment with Nrf2 activator sulforaphane (SFN) prevented the depression-like phenotype induced after repeated social defeat stress.	sulforaphane	33-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
27470577-6	2016	Pretreatment with Nrf2 activator sulforaphane (SFN) prevented the depression-like phenotype induced after repeated social defeat stress.	sulforaphane	47-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
27470577-8	2016	These findings suggest that Keap1-Nrf2 system plays a key role in depression and that dietary intake of SFN-rich food during juvenile stages and adolescence can confer stress resilience in adulthood.	sulforaphane	104-107	kelch-like ECH-associated protein 1	Mus musculus	28-33
27450419-0	2016	A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation.	sulforaphane	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
27450419-1	2016	UNLABELLED: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2).	sulforaphane	12-24	NFE2 like bZIP transcription factor 2	Homo sapiens	204-226
27450419-1	2016	UNLABELLED: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2).	sulforaphane	12-24	NFE2 like bZIP transcription factor 2	Homo sapiens	228-232
27450419-1	2016	UNLABELLED: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2).	sulforaphane	26-29	NFE2 like bZIP transcription factor 2	Homo sapiens	204-226
27450419-1	2016	UNLABELLED: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2).	sulforaphane	26-29	NFE2 like bZIP transcription factor 2	Homo sapiens	228-232
27261601-8	2016	This review deals with plant derived HDACi sulphoraphane (SFN; 1-isothiocyanato-4-(methylsulfinyl)-butane) and its potential role in prostate cancer therapy along with the underlying molecular mechanism being involved.	sulforaphane	43-56	RNA exonuclease 2	Homo sapiens	58-61
27261601-8	2016	This review deals with plant derived HDACi sulphoraphane (SFN; 1-isothiocyanato-4-(methylsulfinyl)-butane) and its potential role in prostate cancer therapy along with the underlying molecular mechanism being involved.	sulforaphane	63-105	RNA exonuclease 2	Homo sapiens	58-61
27339168-4	2016	Sulforaphane treatment of Het-1A, a normal mucosal epithelial cell line, and 4 HNSCC cell lines led to dose- and time-dependent induction of NRF2 and the NRF2 target genes NQO1 and GCLC, known mediators of carcinogen detoxication.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
27339168-4	2016	Sulforaphane treatment of Het-1A, a normal mucosal epithelial cell line, and 4 HNSCC cell lines led to dose- and time-dependent induction of NRF2 and the NRF2 target genes NQO1 and GCLC, known mediators of carcinogen detoxication.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
27339168-4	2016	Sulforaphane treatment of Het-1A, a normal mucosal epithelial cell line, and 4 HNSCC cell lines led to dose- and time-dependent induction of NRF2 and the NRF2 target genes NQO1 and GCLC, known mediators of carcinogen detoxication.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	172-176
27339168-4	2016	Sulforaphane treatment of Het-1A, a normal mucosal epithelial cell line, and 4 HNSCC cell lines led to dose- and time-dependent induction of NRF2 and the NRF2 target genes NQO1 and GCLC, known mediators of carcinogen detoxication.	sulforaphane	0-12	glutamate-cysteine ligase catalytic subunit	Homo sapiens	181-185
27339168-5	2016	Sulforaphane also promoted NRF2-independent dephosphorylation/inactivation of pSTAT3, a key oncogenic factor in HNSCC.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
27035641-0	2016	The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line.	sulforaphane	14-26	H3 histone pseudogene 16	Homo sapiens	88-91
27035641-8	2016	We found that the percentage of cyclin D1-positive cells decreased after the treatment with SFN, but at the same time mean fluorescence intensity reflecting cyclin D1 content was increased at 30 microM SFN and decreased at 60 and 90 microM SFN.	sulforaphane	92-95	cyclin D1	Homo sapiens	32-41
26900720-7	2016	Although no changes in mechanical function were observed, sulforaphane induced a significant increase in superoxide dismutase and heme oxygenase-1 expression (both 66%) and significantly reduced reactive oxygen species levels (7%).	sulforaphane	58-70	heme oxygenase 1	Rattus norvegicus	130-146
27183391-7	2016	Topical application of the NRF2 activator sulforaphane to the footpad of Krt16-/- mice prevented the development of PPK and normalized redox balance via regeneration of GSH from existing cellular pools.	sulforaphane	42-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-31
27183391-7	2016	Topical application of the NRF2 activator sulforaphane to the footpad of Krt16-/- mice prevented the development of PPK and normalized redox balance via regeneration of GSH from existing cellular pools.	sulforaphane	42-54	keratin 16	Mus musculus	73-78
27142739-1	2016	Sulforaphane (SFN), a dietary phase-2 enzyme inducer that mitigates cellular oxidative stress through nuclear factor erythroid 2-related factor 2 (Nrf2) activation, is known to exhibit beneficial effects in the vessel wall.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-145
27142739-1	2016	Sulforaphane (SFN), a dietary phase-2 enzyme inducer that mitigates cellular oxidative stress through nuclear factor erythroid 2-related factor 2 (Nrf2) activation, is known to exhibit beneficial effects in the vessel wall.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
27142739-1	2016	Sulforaphane (SFN), a dietary phase-2 enzyme inducer that mitigates cellular oxidative stress through nuclear factor erythroid 2-related factor 2 (Nrf2) activation, is known to exhibit beneficial effects in the vessel wall.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-145
27142739-1	2016	Sulforaphane (SFN), a dietary phase-2 enzyme inducer that mitigates cellular oxidative stress through nuclear factor erythroid 2-related factor 2 (Nrf2) activation, is known to exhibit beneficial effects in the vessel wall.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
27143001-18	2016	Elimination of ROS and NO production by sulforaphane, a natural Nrf2 activator, confirmed the astroglial protective mechanism.	sulforaphane	40-52	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-68
26935987-8	2016	Cotreatment with N-acetyl-L-cysteine inhibited sulforaphane-inhibited invasion and upregulation of E-cadherin and almost completely abolished the sulforaphane-induced expression of Vimentin.	sulforaphane	47-59	cadherin 1	Homo sapiens	99-109
26096705-0	2016	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-kappaB Pathways.	sulforaphane	0-12	kelch-like ECH-associated protein 1	Mus musculus	91-96
26096705-0	2016	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-kappaB Pathways.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
26096705-0	2016	Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-kappaB Pathways.	sulforaphane	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
26096705-6	2016	The protective effects due to pretreatment with SFN were associated with the following: suppression of the formation of a lesion area, neuronal death, succinate dehydrogenase activity, apoptosis, microglial activation, and mRNA or protein expression of inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, and cyclooxygenase-2 in the striatum after 3-NP treatment.	sulforaphane	48-51	tumor necrosis factor	Mus musculus	287-314
26096705-6	2016	The protective effects due to pretreatment with SFN were associated with the following: suppression of the formation of a lesion area, neuronal death, succinate dehydrogenase activity, apoptosis, microglial activation, and mRNA or protein expression of inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, and cyclooxygenase-2 in the striatum after 3-NP treatment.	sulforaphane	48-51	interleukin 1 beta	Mus musculus	316-338
26096705-6	2016	The protective effects due to pretreatment with SFN were associated with the following: suppression of the formation of a lesion area, neuronal death, succinate dehydrogenase activity, apoptosis, microglial activation, and mRNA or protein expression of inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, and cyclooxygenase-2 in the striatum after 3-NP treatment.	sulforaphane	48-51	interleukin 6	Mus musculus	340-344
26096705-6	2016	The protective effects due to pretreatment with SFN were associated with the following: suppression of the formation of a lesion area, neuronal death, succinate dehydrogenase activity, apoptosis, microglial activation, and mRNA or protein expression of inflammatory mediators, including tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6, inducible nitric oxide synthase, and cyclooxygenase-2 in the striatum after 3-NP treatment.	sulforaphane	48-51	prostaglandin-endoperoxide synthase 2	Mus musculus	383-399
26096705-9	2016	Our findings suggest that SFN may effectively attenuate 3-NP-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-kappaB pathways and that SFN has a wide therapeutic time-window for HD-like symptoms.	sulforaphane	26-29	kelch-like ECH-associated protein 1	Mus musculus	105-110
26096705-9	2016	Our findings suggest that SFN may effectively attenuate 3-NP-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-kappaB pathways and that SFN has a wide therapeutic time-window for HD-like symptoms.	sulforaphane	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
26096705-9	2016	Our findings suggest that SFN may effectively attenuate 3-NP-induced striatal toxicity by activating the Keap1-Nrf2-ARE pathway and inhibiting the MAPKs and NF-kappaB pathways and that SFN has a wide therapeutic time-window for HD-like symptoms.	sulforaphane	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
26935987-0	2016	Sulforaphane inhibits TGF-beta-induced epithelial-mesenchymal transition of hepatocellular carcinoma cells via the reactive oxygen species-dependent pathway.	sulforaphane	0-12	transforming growth factor beta 1	Homo sapiens	22-30
26935987-4	2016	Here, we show that sulforaphane inhibits TGF-beta-induced epithelial-mesenchymal transition of hepatocellular carcinoma cell via the reactive oxygen species-dependent pathway.	sulforaphane	19-31	transforming growth factor beta 1	Homo sapiens	41-49
26935987-8	2016	Cotreatment with N-acetyl-L-cysteine inhibited sulforaphane-inhibited invasion and upregulation of E-cadherin and almost completely abolished the sulforaphane-induced expression of Vimentin.	sulforaphane	47-59	vimentin	Homo sapiens	181-189
26935987-8	2016	Cotreatment with N-acetyl-L-cysteine inhibited sulforaphane-inhibited invasion and upregulation of E-cadherin and almost completely abolished the sulforaphane-induced expression of Vimentin.	sulforaphane	146-158	vimentin	Homo sapiens	181-189
26794448-4	2016	METHODS: We have analyzed CAV1 gene expression and associated epigenetic marks (DNA methylation and histone 3 modifications) in the CAV1 promoter in two colon cancer cell lines, under treatment with well established epigenetic modulators, AZA, SAM, TSA and SFN at varying concentrations.	sulforaphane	257-260	caveolin 1	Homo sapiens	132-136
26982588-6	2016	The expression rate of the anti-apoptotic genes (bcl-2 and bcl-xL), and the pro-apoptotic genes (bax and bak) were quantified, and it was found that the expression rate of bcl-2 and bcl-xL genes significantly were decreased when MCF-7 cells were incubated by sulforaphane-loaded nanoparticles.	sulforaphane	259-271	BCL2 apoptosis regulator	Homo sapiens	172-177
27110751-5	2016	SFN, 3d and 14c significantly induced the activation of caspase-3, and reduced the ALDH+ subpopulation in the SUM159 cell line, while the marketed drug doxrubicin(DOX) increased the ALDH+ subpopulation.	sulforaphane	0-3	caspase 3	Homo sapiens	56-65
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	38-50	heme oxygenase 1	Homo sapiens	137-142
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	38-50	NAD(P)H quinone dehydrogenase 1	Homo sapiens	144-148
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	38-50	hemoglobin subunit gamma 1	Homo sapiens	154-158
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	52-55	heme oxygenase 1	Homo sapiens	137-142
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	52-55	NAD(P)H quinone dehydrogenase 1	Homo sapiens	144-148
27071063-3	2016	We found that activation of NRF2 with sulforaphane (SFN) in erythroid progenitors significantly increased the expression of NRF2 targets HMOX1, NQO1, and HBG1 (subunit of fetal hemoglobin) in a dose-dependent manner.	sulforaphane	52-55	hemoglobin subunit gamma 1	Homo sapiens	154-158
27071063-4	2016	Therefore, we hypothesized that NRF2 activation with SFN may offer therapeutic benefits for SCD patients by restoring oxidative capacity and increasing fetal hemoglobin concentration.	sulforaphane	53-56	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
26995087-8	2016	Moreover, protein glycation levels were decreased several-fold in cells overexpressing DJ-1 after addition of the Nrf2 inducer sulforaphane or after transfection with a DJ-1 plasmid.	sulforaphane	127-139	Parkinsonism associated deglycase	Homo sapiens	87-91
26995087-8	2016	Moreover, protein glycation levels were decreased several-fold in cells overexpressing DJ-1 after addition of the Nrf2 inducer sulforaphane or after transfection with a DJ-1 plasmid.	sulforaphane	127-139	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
27090509-12	2016	Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum.	sulforaphane	0-12	interleukin 1 beta	Rattus norvegicus	90-95
27090509-12	2016	Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum.	sulforaphane	0-12	interleukin 4	Rattus norvegicus	111-115
27090509-12	2016	Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum.	sulforaphane	0-12	interleukin 10	Rattus norvegicus	117-122
27090509-12	2016	Sulforaphane promotes polarization of microglia from the M1 to the M2 phenotype, reducing IL-1b and increasing IL-4, IL-10, Arg1, and YM-1 in the cerebellum.	sulforaphane	0-12	arginase 1	Rattus norvegicus	124-128
27075683-2	2016	Therefore, we investigated whether oral administration of sulforaphane (SFN) prevented high-fat diet-induced NAFLD in mice by regulation of the NLRP3 inflammasome in the liver.	sulforaphane	58-70	NLR family, pyrin domain containing 3	Mus musculus	144-149
27075683-2	2016	Therefore, we investigated whether oral administration of sulforaphane (SFN) prevented high-fat diet-induced NAFLD in mice by regulation of the NLRP3 inflammasome in the liver.	sulforaphane	72-75	NLR family, pyrin domain containing 3	Mus musculus	144-149
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	NLR family, pyrin domain containing 3	Mus musculus	46-51
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	PYD and CARD domain containing	Mus musculus	139-142
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	caspase 1	Mus musculus	147-156
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	caspase 1	Mus musculus	158-167
27075683-4	2016	These were correlated with the suppression of NLRP3 inflammasome activation in the liver by SFN as evidenced by decrease in mRNA levels of ASC and caspase-1, caspase-1 enzyme activity, and IL-1beta levels.	sulforaphane	92-95	interleukin 1 beta	Mus musculus	189-197
27075683-5	2016	SFN inhibited saturated fatty acid-induced activation of the NLRP3 inflammasome in primary mouse hepatocytes, accompanied by the restoration of mitochondrial dysfunction.	sulforaphane	0-3	NLR family, pyrin domain containing 3	Mus musculus	61-66
27075683-6	2016	The suppression of NLRP3 inflammasome by SFN was mediated by the regulation of AMP-activated protein kinase-autophagy axis.	sulforaphane	41-44	NLR family, pyrin domain containing 3	Mus musculus	19-24
26890455-4	2016	On VEGF-SF-CS and SF-CS scaffolds, the cell adhesion rate was increased as time went on.	sulforaphane	8-10	vascular endothelial growth factor A	Homo sapiens	3-7
26775664-0	2016	Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress.	sulforaphane	0-12	sirtuin 1	Rattus norvegicus	99-104
26775664-10	2016	Co-treatment of the cardiomyocytes with the SIRT1-specific inhibitor Ex-527 (1 mumol/L) blocked the SFN-induced cardioprotective effects.	sulforaphane	100-103	sirtuin 1	Rattus norvegicus	44-49
26898427-8	2016	Further, SFN induced apoptosis, increased the accumulation of cells at G0/G1 and G2/M and arrest cells at S phase.	sulforaphane	9-12	allograft inflammatory factor 1	Mus musculus	71-85
26315609-3	2016	OBJECTIVE: To establish a bladder tumor transplantation animal model and to evaluate the inhibitory effects of a novel perfusate, Su Fu"ning Lotion (SFN), on bladder tumor.	sulforaphane	149-152	SUFU negative regulator of hedgehog signaling	Mus musculus	130-135
26890455-7	2016	Cell Counting Kit-8 and alkaline phosphatase analysis proved that the VEGF could significantly promote human fetal osteoblast1.19 cells growth and proliferation in the SF-CS scaffolds, but the enhancement of osteoblasts cell proliferation and activity by VEGF was dependent on time.	sulforaphane	168-170	vascular endothelial growth factor A	Homo sapiens	70-74
26775663-9	2016	Ginkgolide B increased the expression of CYP3A4 and MDR1 in the cells, which was partially reversed by pretreatment with the selective PXR signaling antagonist sulforaphane, or transfection with PXR siRNA.	sulforaphane	160-172	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	41-47
26494449-0	2016	Sulforaphane mitigates muscle fibrosis in mdx mice via Nrf2-mediated inhibition of TGF-beta/Smad signaling.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
26494449-1	2016	Sulforaphane (SFN), an activator of NF-E2-related factor 2 (Nrf2), has been found to have an antifibrotic effect on liver and lung.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-58
26494449-1	2016	Sulforaphane (SFN), an activator of NF-E2-related factor 2 (Nrf2), has been found to have an antifibrotic effect on liver and lung.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
26494449-1	2016	Sulforaphane (SFN), an activator of NF-E2-related factor 2 (Nrf2), has been found to have an antifibrotic effect on liver and lung.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-58
26494449-1	2016	Sulforaphane (SFN), an activator of NF-E2-related factor 2 (Nrf2), has been found to have an antifibrotic effect on liver and lung.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-64
26494449-3	2016	This work was undertaken to evaluate the effects of SFN-mediated activation of Nrf2 on dystrophic muscle fibrosis.	sulforaphane	52-55	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
27026929-4	2016	Apoptotic effects of SFN were evaluated by annexin V binding capacity with flow cytometric analysis.	sulforaphane	21-24	annexin A5	Homo sapiens	43-52
26838095-6	2016	In 80% of sarcoids, SFs were strongly positive for vimentin and negative for alpha-SMA; the remaining sarcoid samples (20%) showed 70-80% of SFs labeled for vim and approximately 20-30% labeled for alpha-SMA.	sulforaphane	20-23	vimentin	Equus caballus	51-59
26838095-6	2016	In 80% of sarcoids, SFs were strongly positive for vimentin and negative for alpha-SMA; the remaining sarcoid samples (20%) showed 70-80% of SFs labeled for vim and approximately 20-30% labeled for alpha-SMA.	sulforaphane	20-23	vimentin	Equus caballus	51-54
26775663-9	2016	Ginkgolide B increased the expression of CYP3A4 and MDR1 in the cells, which was partially reversed by pretreatment with the selective PXR signaling antagonist sulforaphane, or transfection with PXR siRNA.	sulforaphane	160-172	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
26775663-9	2016	Ginkgolide B increased the expression of CYP3A4 and MDR1 in the cells, which was partially reversed by pretreatment with the selective PXR signaling antagonist sulforaphane, or transfection with PXR siRNA.	sulforaphane	160-172	nuclear receptor subfamily 1 group I member 2	Homo sapiens	135-138
26490346-9	2016	SFN administration significantly decreased HCD-induced elevations in serum TC, LDL-C, CRP, and LDH.	sulforaphane	0-3	C-reactive protein	Oryctolagus cuniculus	86-89
26458818-4	2016	In this study, we found that SFN can inhibit the expression and activity of human telomerase reverse transcriptase (hTERT), the catalytic subunit of telomerase, in 2 prostate cancer cell lines.	sulforaphane	29-32	telomerase reverse transcriptase	Homo sapiens	116-121
26458818-6	2016	The SFN-mediated changes in levels of histone post-translational modifications, more specifically acetylation of histone H3 lysine 18 and di-methylation of histone H3 lysine 4, 2 modifications linked with high risk of prostate cancer recurrence, were associated with regulatory elements within the hTERT promoter region.	sulforaphane	4-7	telomerase reverse transcriptase	Homo sapiens	298-303
26458818-7	2016	Chromatin condensation may also play a role in SFN-mediated hTERT repression, since expression and recruitment of MeCP2, a known chromatin compactor, were altered in SFN treated prostate cancer cells.	sulforaphane	47-50	telomerase reverse transcriptase	Homo sapiens	60-65
26458818-7	2016	Chromatin condensation may also play a role in SFN-mediated hTERT repression, since expression and recruitment of MeCP2, a known chromatin compactor, were altered in SFN treated prostate cancer cells.	sulforaphane	47-50	methyl-CpG binding protein 2	Homo sapiens	114-119
26458818-9	2016	These combined results strongly support a role for SFN in the mediation of epigenetic events leading to the repression of hTERT in prostate cancer cells.	sulforaphane	51-54	telomerase reverse transcriptase	Homo sapiens	122-127
26648123-0	2016	Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-kappaB-dependent pathway downregulating MGMT expression.	sulforaphane	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-89
26698667-10	2016	Our findings suggest that cardamonin interferes with the biosynthesis of Nrf2-regulated selenoenzymes, in contrast to the Nrf2-activating isothiocyanate compound sulforaphane, which has been shown earlier to synergize with Se-mediated cytoprotection.	sulforaphane	162-174	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
26648123-0	2016	Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-kappaB-dependent pathway downregulating MGMT expression.	sulforaphane	0-12	O-6-methylguanine-DNA methyltransferase	Mus musculus	123-127
26648123-2	2016	We elucidated the mechanisms of sulforaphane (SFN) reverse TMZ resistance in TMZ-inducing cell lines by inhibiting nuclear factor-kappaB (NF-kappaB) transcriptional activity.	sulforaphane	32-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-136
26648123-2	2016	We elucidated the mechanisms of sulforaphane (SFN) reverse TMZ resistance in TMZ-inducing cell lines by inhibiting nuclear factor-kappaB (NF-kappaB) transcriptional activity.	sulforaphane	32-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-147
26648123-2	2016	We elucidated the mechanisms of sulforaphane (SFN) reverse TMZ resistance in TMZ-inducing cell lines by inhibiting nuclear factor-kappaB (NF-kappaB) transcriptional activity.	sulforaphane	46-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-136
26648123-2	2016	We elucidated the mechanisms of sulforaphane (SFN) reverse TMZ resistance in TMZ-inducing cell lines by inhibiting nuclear factor-kappaB (NF-kappaB) transcriptional activity.	sulforaphane	46-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-147
26970133-6	2016	One key molecular mechanism of action for sulforaphane entails activation of the Nrf2-Keap1 signaling pathway although other actions contribute to the broad spectrum of efficacy in different animal models.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
26827637-0	2016	Sulforaphane exerts its anti-inflammatory effect against amyloid-beta peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages.	sulforaphane	0-12	amyloid beta precursor protein	Homo sapiens	57-69
26827637-0	2016	Sulforaphane exerts its anti-inflammatory effect against amyloid-beta peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages.	sulforaphane	0-12	signal transducer and activator of transcription 1	Homo sapiens	82-88
26827637-0	2016	Sulforaphane exerts its anti-inflammatory effect against amyloid-beta peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
26827637-0	2016	Sulforaphane exerts its anti-inflammatory effect against amyloid-beta peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	130-134
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	cathepsin B	Homo sapiens	62-73
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	caspase 1	Homo sapiens	79-88
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	NLR family pyrin domain containing 3	Homo sapiens	99-104
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	TNF receptor superfamily member 8	Homo sapiens	242-250
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	interleukin 1 beta	Homo sapiens	251-268
26827637-3	2016	The results showed that sulforaphane preferentially inhibited cathepsin B- and caspase-1-dependent NLRP3 inflammasome activation induced by mostly Abeta1-42 monomers, an effect that potently reduced excessive secretion of the proinflammatory cytokine interleukin-1beta (IL-1beta).	sulforaphane	24-36	interleukin 1 alpha	Homo sapiens	270-278
26827637-4	2016	Subsequent mechanistic studies revealed that sulforaphane mitigated the activation of signal transducer and activator of transcription-1 induced by Abeta1-42 monomers.	sulforaphane	45-57	signal transducer and activator of transcription 1	Homo sapiens	86-136
26827637-5	2016	Sulforaphane also increased nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, which was followed by upregulation of heme-oxygenase 1 (HO-1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	28-71
26827637-5	2016	Sulforaphane also increased nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, which was followed by upregulation of heme-oxygenase 1 (HO-1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
26827637-5	2016	Sulforaphane also increased nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, which was followed by upregulation of heme-oxygenase 1 (HO-1).	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	140-156
26827637-5	2016	Sulforaphane also increased nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation, which was followed by upregulation of heme-oxygenase 1 (HO-1).	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	158-162
26827637-6	2016	The anti-inflammatory effect of sulforaphane on Abeta1-42-induced IL-1beta production was diminished by small interfering RNA-mediated knockdown of Nrf2 or HO-1.	sulforaphane	32-44	interleukin 1 alpha	Homo sapiens	66-74
26827637-6	2016	The anti-inflammatory effect of sulforaphane on Abeta1-42-induced IL-1beta production was diminished by small interfering RNA-mediated knockdown of Nrf2 or HO-1.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
26827637-6	2016	The anti-inflammatory effect of sulforaphane on Abeta1-42-induced IL-1beta production was diminished by small interfering RNA-mediated knockdown of Nrf2 or HO-1.	sulforaphane	32-44	heme oxygenase 1	Homo sapiens	156-160
26827637-7	2016	Moreover, sulforaphane significantly attenuated the levels of microRNA-146a, which is selectively upregulated in the temporal cortex and hippocampus of AD brains.	sulforaphane	10-22	microRNA 146a	Homo sapiens	62-75
26827637-8	2016	The aforementioned effects of sulforaphane were replicated by the tyrosine kinase inhibitor, herbimycin A, and Nrf2 activator.	sulforaphane	30-42	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
26827637-9	2016	These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells.	sulforaphane	212-224	signal transducer and activator of transcription 1	Homo sapiens	28-78
26827637-9	2016	These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells.	sulforaphane	212-224	heme oxygenase 1	Homo sapiens	98-102
26827637-9	2016	These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells.	sulforaphane	212-224	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
26827637-9	2016	These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells.	sulforaphane	212-224	interleukin 1 alpha	Homo sapiens	254-262
26827637-9	2016	These results indicate that signal transducer and activator of transcription-1 dephosphorylation, HO-1 and its upstream effector, Nrf2, play a pivotal role in triggering an anti-inflammatory signaling cascade of sulforaphane that results in decreases of IL-1beta release and microRNA-146a production in Abeta1-42-stimulated human microglia-like cells.	sulforaphane	212-224	microRNA 146a	Homo sapiens	275-288
26970133-6	2016	One key molecular mechanism of action for sulforaphane entails activation of the Nrf2-Keap1 signaling pathway although other actions contribute to the broad spectrum of efficacy in different animal models.	sulforaphane	42-54	kelch like ECH associated protein 1	Homo sapiens	86-91
26571201-0	2016	Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
30090379-10	2016	In contrast, treating uranium-exposed kidney cells with Nrf2 activator (sulforaphane) preserved the protein levels of Nrf2, CBS and CSE, and endogenous H2S formation.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	56-60
30090379-10	2016	In contrast, treating uranium-exposed kidney cells with Nrf2 activator (sulforaphane) preserved the protein levels of Nrf2, CBS and CSE, and endogenous H2S formation.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
30090379-10	2016	In contrast, treating uranium-exposed kidney cells with Nrf2 activator (sulforaphane) preserved the protein levels of Nrf2, CBS and CSE, and endogenous H2S formation.	sulforaphane	72-84	cystathionine beta synthase	Rattus norvegicus	124-127
30090379-10	2016	In contrast, treating uranium-exposed kidney cells with Nrf2 activator (sulforaphane) preserved the protein levels of Nrf2, CBS and CSE, and endogenous H2S formation.	sulforaphane	72-84	cystathionine gamma-lyase	Rattus norvegicus	132-135
28959534-7	2016	Both sulforaphane and oltipraz increased the expression of anti-oxidant genes GCLC and NQO1.	sulforaphane	5-17	glutamate-cysteine ligase catalytic subunit	Homo sapiens	78-82
28959534-7	2016	Both sulforaphane and oltipraz increased the expression of anti-oxidant genes GCLC and NQO1.	sulforaphane	5-17	NAD(P)H quinone dehydrogenase 1	Homo sapiens	87-91
27627923-6	2016	Apoptotic cell death was also confirmed by Annexin V/PI and DAPI staining and DNA gel electrophoresis in HCT 116 cells after exposure to SFN.	sulforaphane	137-140	annexin A5	Homo sapiens	43-52
27627923-7	2016	The flow cytometric assay also showed that SFN induced the generation of reactive oxygen species (ROS) and Ca[Formula: see text] and decreased mitochondria membrane potential and increased caspase-8, -9 and -3 activities in HCT 116 cell.	sulforaphane	43-46	caspase 8	Homo sapiens	189-209
27627923-8	2016	Western blotting also showed that SFN induced the release of cytochrome c, and AIF, which was confirmed by confocal microscopy examination.	sulforaphane	34-37	cytochrome c, somatic	Homo sapiens	61-73
27497670-11	2016	SFN also attenuated the abnormal expression of Caspase-3 and MCL-1 in diabetic model.	sulforaphane	0-3	caspase 3	Rattus norvegicus	47-56
27497670-11	2016	SFN also attenuated the abnormal expression of Caspase-3 and MCL-1 in diabetic model.	sulforaphane	0-3	MCL1 apoptosis regulator, BCL2 family member	Rattus norvegicus	61-66
26571201-2	2016	The objectives of this study were to examine the effects of the bioactive sulforaphane (SFN) on the nuclear factor E2-related factor 2 (Nrf2) pathway in BV2 microglia and primary microglia, and to evaluate proinflammatory cytokine expression in lipopolysaccharide (LPS)-stimulated primary microglia from adult and aged mice.	sulforaphane	74-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
26571201-2	2016	The objectives of this study were to examine the effects of the bioactive sulforaphane (SFN) on the nuclear factor E2-related factor 2 (Nrf2) pathway in BV2 microglia and primary microglia, and to evaluate proinflammatory cytokine expression in lipopolysaccharide (LPS)-stimulated primary microglia from adult and aged mice.	sulforaphane	88-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
26623679-5	2016	Moreover, our findings demonstrate that relatively low concentrations of either sulforaphane or curcumin significantly (P < .05) increase NQO1 protein expression and activity without triggering G2/M cell cycle arrest or mitotic catastrophe.	sulforaphane	80-92	NAD(P)H dehydrogenase, quinone 1	Mus musculus	141-145
26531002-0	2016	Sulforaphane exerts anti-inflammatory effects against lipopolysaccharide-induced acute lung injury in mice through the Nrf2/ARE pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
26531002-5	2016	Our results revealed that sulforaphane significantly decreased lactate dehydrogenase (LDH) activity (as shown by LDH assay), the wet-to-dry ratio of the lungs and the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) (measured by ELISA), as well as nuclear factor-kappaB protein expression in mice with LPS-induced ALI.	sulforaphane	26-38	interleukin 6	Mus musculus	183-196
26531002-5	2016	Our results revealed that sulforaphane significantly decreased lactate dehydrogenase (LDH) activity (as shown by LDH assay), the wet-to-dry ratio of the lungs and the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) (measured by ELISA), as well as nuclear factor-kappaB protein expression in mice with LPS-induced ALI.	sulforaphane	26-38	interleukin 6	Mus musculus	198-202
26531002-5	2016	Our results revealed that sulforaphane significantly decreased lactate dehydrogenase (LDH) activity (as shown by LDH assay), the wet-to-dry ratio of the lungs and the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) (measured by ELISA), as well as nuclear factor-kappaB protein expression in mice with LPS-induced ALI.	sulforaphane	26-38	tumor necrosis factor	Mus musculus	208-235
26531002-5	2016	Our results revealed that sulforaphane significantly decreased lactate dehydrogenase (LDH) activity (as shown by LDH assay), the wet-to-dry ratio of the lungs and the serum levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) (measured by ELISA), as well as nuclear factor-kappaB protein expression in mice with LPS-induced ALI.	sulforaphane	26-38	tumor necrosis factor	Mus musculus	237-246
26531002-6	2016	Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI.	sulforaphane	25-37	prostaglandin-endoperoxide synthase 2	Mus musculus	102-118
26531002-6	2016	Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI.	sulforaphane	25-37	prostaglandin-endoperoxide synthase 2	Mus musculus	120-125
26531002-6	2016	Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI.	sulforaphane	25-37	matrix metallopeptidase 9	Mus musculus	128-154
26531002-6	2016	Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI.	sulforaphane	25-37	matrix metallopeptidase 9	Mus musculus	156-161
26531002-6	2016	Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI.	sulforaphane	25-37	nitric oxide synthase 2, inducible	Mus musculus	230-261
26531002-6	2016	Moreover, treatment with sulforaphane significantly inhibited prostaglandin E2 (PGE2) production, and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) protein expression (as shown by western blot analysis), as well as inducible nitric oxide synthase (iNOS) activity in mice with LPS-induced ALI.	sulforaphane	25-37	nitric oxide synthase 2, inducible	Mus musculus	263-267
26531002-7	2016	Lastly, we noted that pre-treatment with sulforaphane activated the nuclear factor-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway in the mice with LPS-induced ALI.	sulforaphane	41-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
26531002-8	2016	These findings demonstrate that sulforaphane exerts protective effects against LPS-induced ALI through the Nrf2/ARE pathway.	sulforaphane	32-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	NLR family, pyrin domain containing 3	Mus musculus	238-243
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	apoptosis inhibitor 5	Mus musculus	256-286
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	caspase 1	Mus musculus	298-307
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	NLR family, apoptosis inhibitory protein 5	Mus musculus	349-354
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	NLR family, CARD domain containing 4	Mus musculus	355-360
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	absent in melanoma 2	Mus musculus	367-387
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	absent in melanoma 2	Mus musculus	389-393
26269198-7	2016	Furthermore, sulforaphane-mediated inhibition of the inflammasomes is independent of the transcription factor nuclear factor erythroid-derived 2-like factor 2 (Nrf2) and the antioxidant response-element pathway, to which many of the antioxidant and anti-inflammatory effects of sulforaphane have been attributed.	sulforaphane	13-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-158
26269198-7	2016	Furthermore, sulforaphane-mediated inhibition of the inflammasomes is independent of the transcription factor nuclear factor erythroid-derived 2-like factor 2 (Nrf2) and the antioxidant response-element pathway, to which many of the antioxidant and anti-inflammatory effects of sulforaphane have been attributed.	sulforaphane	13-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164
26269198-8	2016	Sulforaphane was also found to inhibit cell recruitment to the peritoneum and interleukin-1beta secretion in an in vivo peritonitis model of acute gout and to reverse NLRP1-mediated murine resistance to Bacillus anthracis spore infection.	sulforaphane	0-12	interleukin 1 beta	Mus musculus	78-95
26269198-8	2016	Sulforaphane was also found to inhibit cell recruitment to the peritoneum and interleukin-1beta secretion in an in vivo peritonitis model of acute gout and to reverse NLRP1-mediated murine resistance to Bacillus anthracis spore infection.	sulforaphane	0-12	NLR family, pyrin domain containing 1A	Mus musculus	167-172
26269198-0	2016	Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	caspase 1	Mus musculus	41-50
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	interleukin 1 beta	Mus musculus	82-99
26269198-5	2016	We discovered that sulforaphane inhibits caspase-1 autoproteolytic activation and interleukin-1beta maturation and secretion downstream of the nucleotide-binding oligomerization domain-like receptor leucine-rich repeat proteins NLRP1 and NLRP3, NLR family apoptosis inhibitory protein 5/NLR family caspase-1 recruitment domain-containing protein 4 (NAIP5/NLRC4), and absent in melanoma 2 (AIM2) inflammasome receptors.	sulforaphane	19-31	NLR family, pyrin domain containing 1A	Mus musculus	228-233
26881038-2	2016	The aim of this review is to describe the properties of nutrigenomic activators of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), comparing the potential for sulforaphane and other phytochemicals to demonstrate clinical efficacy as complementary medicines.	sulforaphane	184-196	NFE2 like bZIP transcription factor 2	Homo sapiens	110-153
27006750-0	2016	Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
26881038-4	2016	Compared with widely used phytochemical-based supplements like curcumin, silymarin, and resveratrol, sulforaphane more potently activates Nrf2 to induce the expression of a battery of cytoprotective genes.	sulforaphane	101-113	NFE2 like bZIP transcription factor 2	Homo sapiens	138-142
27006750-0	2016	Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	70-74
26881038-5	2016	By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2.	sulforaphane	61-73	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
26881038-7	2016	Both its high bioavailability and significant Nrf2 inducer capacity contribute to the therapeutic potential of sulforaphane-yielding supplements.	sulforaphane	111-123	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
27847555-0	2016	Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	101-106
27847555-0	2016	Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
27433291-0	2016	Sulforaphane Ameliorates Bladder Dysfunction through Activation of the Nrf2-ARE Pathway in a Rat Model of Partial Bladder Outlet Obstruction.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
27433291-2	2016	We evaluated the effect of sulforaphane (SFN) treatment on the function and changes of expression of Nrf2-ARE pathway in the bladder of rats with bladder outlet obstruction (BOO).	sulforaphane	27-39	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
27433291-2	2016	We evaluated the effect of sulforaphane (SFN) treatment on the function and changes of expression of Nrf2-ARE pathway in the bladder of rats with bladder outlet obstruction (BOO).	sulforaphane	41-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
27433291-15	2016	The sulforaphane-mediated decrease of oxidative stress and activation of the Nrf2-ARE pathway may ameliorate bladder dysfunction caused by bladder outlet obstruction.	sulforaphane	4-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81
27847555-8	2016	SFN administration reverted AP-associated dysregulation of oxidative stress markers including pancreatic malondialdehyde and redox enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx).	sulforaphane	0-3	superoxide dismutase 1, soluble	Mus musculus	161-164
26498863-8	2015	These data suggest that sulforaphane may inhibit human colon cancer progression and cancer cell angiogenesis by inhibiting HIF-1alpha and VEGF expression.	sulforaphane	24-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
26454883-7	2016	Sulforaphane, an activator of Nrf2, increased Mrp1 mRNA, protein, and functional activity in primary keratinocytes and PAM212 cells and decreased their sensitivity to HN2-induced growth inhibition (IC(50) = 1.4 and 4.8 microM in primary keratinocytes and 1 and 13 microM in PAM212 cells, in the absence and presence of sulforaphane, respectively).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
26454883-7	2016	Sulforaphane, an activator of Nrf2, increased Mrp1 mRNA, protein, and functional activity in primary keratinocytes and PAM212 cells and decreased their sensitivity to HN2-induced growth inhibition (IC(50) = 1.4 and 4.8 microM in primary keratinocytes and 1 and 13 microM in PAM212 cells, in the absence and presence of sulforaphane, respectively).	sulforaphane	0-12	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	46-50
26454883-7	2016	Sulforaphane, an activator of Nrf2, increased Mrp1 mRNA, protein, and functional activity in primary keratinocytes and PAM212 cells and decreased their sensitivity to HN2-induced growth inhibition (IC(50) = 1.4 and 4.8 microM in primary keratinocytes and 1 and 13 microM in PAM212 cells, in the absence and presence of sulforaphane, respectively).	sulforaphane	319-331	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
26454883-8	2016	The Mrp1 inhibitor, MK-571, reversed the effects of sulforaphane on HN2-induced growth inhibition in both primary keratinocytes and PAM212 cells.	sulforaphane	52-64	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	4-8
26415026-0	2015	Metallothionein plays a prominent role in the prevention of diabetic nephropathy by sulforaphane via up-regulation of Nrf2.	sulforaphane	84-96	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
26415026-1	2015	Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 1 diabetes via up-regulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
26415026-1	2015	Sulforaphane (SFN) prevents diabetic nephropathy (DN) in type 1 diabetes via up-regulation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
26498863-0	2015	Sulforaphane inhibits hypoxia-induced HIF-1alpha and VEGF expression and migration of human colon cancer cells.	sulforaphane	0-12	vascular endothelial growth factor A	Homo sapiens	53-57
26498863-1	2015	The effects of sulforaphane (a natural product commonly found in broccoli) was investigated on hypoxia inducible factor-1alpha (HIF-1alpha) expression in HCT116 human colon cancer cells and AGS human gastric cancer cells.	sulforaphane	15-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	95-126
26498863-1	2015	The effects of sulforaphane (a natural product commonly found in broccoli) was investigated on hypoxia inducible factor-1alpha (HIF-1alpha) expression in HCT116 human colon cancer cells and AGS human gastric cancer cells.	sulforaphane	15-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
26498863-3	2015	Treatment with sulforaphane inhibited hypoxia-induced vascular endothelial growth factor (VEGF) expression in HCT116 cells.	sulforaphane	15-27	vascular endothelial growth factor A	Homo sapiens	54-88
26498863-3	2015	Treatment with sulforaphane inhibited hypoxia-induced vascular endothelial growth factor (VEGF) expression in HCT116 cells.	sulforaphane	15-27	vascular endothelial growth factor A	Homo sapiens	90-94
26498863-4	2015	Treatment with sulforaphane modulated the effect of hypoxia on HIF-1alpha stability.	sulforaphane	15-27	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
26498863-5	2015	However, degradation of HIF-1alpha by sulforaphane was not mediated through the 26S proteasome pathway.	sulforaphane	38-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	24-34
26498863-6	2015	We also found that the inhibition of HIF-1alpha by sulforaphane was not mediated through AKT and extracellular signal-regulated kinase phosphorylation under hypoxic conditions.	sulforaphane	51-63	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
26498863-8	2015	These data suggest that sulforaphane may inhibit human colon cancer progression and cancer cell angiogenesis by inhibiting HIF-1alpha and VEGF expression.	sulforaphane	24-36	vascular endothelial growth factor A	Homo sapiens	138-142
26310710-0	2015	Sulforaphane inhibits damage-induced poly (ADP-ribosyl)ation via direct interaction of its cellular metabolites with PARP-1.	sulforaphane	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	117-123
26365487-2	2015	Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal mitochondrial bioenergetics.	sulforaphane	55-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
26365487-11	2015	We also found antioxidant effects of sulforaphane in mouse plasma and hippocampal formations, exhibited by increased catalase and superoxide dismutase (SOD) activity, as well as increased abilities of hippocampal mitochondria to produce ATP.	sulforaphane	37-49	catalase	Mus musculus	117-125
26545810-6	2015	CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners.	sulforaphane	22-25	calmodulin like 5	Homo sapiens	0-6
26545810-6	2015	CALML5 interacts with SFN in suprabasal epidermis, cocontrols 13% of late differentiation genes, and modulates interaction of SFN to some of its binding partners.	sulforaphane	126-129	calmodulin like 5	Homo sapiens	0-6
25307283-0	2015	The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses.	sulforaphane	14-26	histone deacetylase 9	Homo sapiens	30-49
25307283-1	2015	Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes.	sulforaphane	0-12	histone deacetylase 9	Homo sapiens	147-166
25307283-1	2015	Sulforaphane is a natural product found in broccoli, which is known to exert many different molecular effects in the cell, including inhibition of histone deacetylase (HDAC) enzymes.	sulforaphane	0-12	histone deacetylase 9	Homo sapiens	168-172
25307283-3	2015	Significant inhibition of HDAC activity in HCT116 nuclear extracts required prolonged exposure to sulforaphane in the presence of serum.	sulforaphane	98-110	histone deacetylase 9	Homo sapiens	26-30
25307283-5	2015	Both cell types displayed down-regulation of HDAC protein levels by sulforaphane treatment.	sulforaphane	68-80	histone deacetylase 9	Homo sapiens	45-49
25307283-6	2015	Despite these reductions in HDAC family member protein levels, acetylation of marker proteins (acetylated Histone H3, H4, and tubulin) was decreased by sulforaphane treatment.	sulforaphane	152-164	histone deacetylase 9	Homo sapiens	28-32
25307283-7	2015	Time-course analysis revealed that HDAC6, HDAC3, and acetylated histone H3 protein levels are significantly inhibited as early as 6 h into sulforaphane treatment.	sulforaphane	139-151	histone deacetylase 6	Homo sapiens	35-40
25307283-7	2015	Time-course analysis revealed that HDAC6, HDAC3, and acetylated histone H3 protein levels are significantly inhibited as early as 6 h into sulforaphane treatment.	sulforaphane	139-151	histone deacetylase 3	Homo sapiens	42-47
25307283-10	2015	In addition, our data suggest that keratinocytes are at least partially resistant to the nuclear HDAC inhibitory effects of sulforaphane, which is exhibited in HCT116 and other cells.	sulforaphane	124-136	histone deacetylase 9	Homo sapiens	97-101
26604696-10	2015	The activation of Nrf2-ARE signaling pathway by SFN can elevate expression of antioxidant enzyme HO-1, reduce perifocal inflammatory response after ICH, and thus may play a neuroprotective role.	sulforaphane	48-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-22
26522776-8	2015	Transformed resistant cells were sensitive to chemical probe (sulforaphane) through inhibition of IL-6/STAT3/NF-kappaB positive feedback loop whereas parental HER2(+) cells did not respond.	sulforaphane	62-74	interleukin 6	Homo sapiens	98-102
26522776-8	2015	Transformed resistant cells were sensitive to chemical probe (sulforaphane) through inhibition of IL-6/STAT3/NF-kappaB positive feedback loop whereas parental HER2(+) cells did not respond.	sulforaphane	62-74	signal transducer and activator of transcription 3	Homo sapiens	103-108
26522776-8	2015	Transformed resistant cells were sensitive to chemical probe (sulforaphane) through inhibition of IL-6/STAT3/NF-kappaB positive feedback loop whereas parental HER2(+) cells did not respond.	sulforaphane	62-74	nuclear factor kappa B subunit 1	Homo sapiens	109-118
26522776-8	2015	Transformed resistant cells were sensitive to chemical probe (sulforaphane) through inhibition of IL-6/STAT3/NF-kappaB positive feedback loop whereas parental HER2(+) cells did not respond.	sulforaphane	62-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	159-163
26310710-7	2015	Interestingly, this sulforaphane metabolite-induced PARP-1 inhibition was prevented by thiol compounds.	sulforaphane	20-32	poly(ADP-ribose) polymerase 1	Homo sapiens	52-58
26310710-8	2015	PARP-1 is a stimulating factor for DNA SSBR-rate and we further demonstrated that 25 muM sulforaphane also delayed the rejoining of H2 O2 -induced DNA strand breaks, although this might be partly due to increased lesion frequencies.	sulforaphane	89-101	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
26958603-0	2015	Differential expression patterns of Nqo1, AKR1B8 and Ho-1 in the liver and small intestine of C57BL/6 mice treated with sulforaphane.	sulforaphane	120-132	NAD(P)H dehydrogenase, quinone 1	Mus musculus	36-40
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	tumor necrosis factor	Rattus norvegicus	145-178
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	interleukin 1 beta	Rattus norvegicus	183-205
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	nitric oxide synthase 2	Rattus norvegicus	248-279
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	nitric oxide synthase 2	Rattus norvegicus	281-285
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	nitric oxide synthase 2	Rattus norvegicus	325-329
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	334-350
26770373-5	2015	We found that sulforaphane significantly attenuated the blood-brain barrier (BBB) disruption; decreased the levels of pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta; reduced the nitric oxide (NO) levels and inducible nitric oxide synthase (iNOS) activity; inhibited the expression of iNOS and cyclooxygenase-2 (COX-2).	sulforaphane	14-26	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	352-357
26770373-6	2015	In addition, sulforaphane inhibits the expression of p-NF-kappaB p65 after focal cerebral ischemia-reperfusion injury.	sulforaphane	13-25	synaptotagmin 1	Rattus norvegicus	65-68
26958603-4	2015	The mice were given a 25 mg/kg single oral dose of SFN for 24 h and 48 h. Immunohistochemistry revealed that, in the liver from WT mice, SFN increased Nqo1 staining in hepatocytes with slight higher staining in the pericentral region.	sulforaphane	137-140	NAD(P)H dehydrogenase, quinone 1	Mus musculus	151-155
26338358-3	2015	Rate constants for the inactivation of PTP1B and SHP-2 by allyl isothiocyanate and sulforaphane range from 2 to 16 M(-1)s(-1).	sulforaphane	83-95	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	39-44
26338358-3	2015	Rate constants for the inactivation of PTP1B and SHP-2 by allyl isothiocyanate and sulforaphane range from 2 to 16 M(-1)s(-1).	sulforaphane	83-95	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	49-54
26296464-0	2015	Sulforaphane induces apoptosis in adipocytes via Akt/p70s6k1/Bad inhibition and ERK activation.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	49-52
26296464-0	2015	Sulforaphane induces apoptosis in adipocytes via Akt/p70s6k1/Bad inhibition and ERK activation.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	80-83
26296464-5	2015	Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio.	sulforaphane	31-34	poly(ADP-ribose) polymerase 1	Homo sapiens	137-163
26296464-5	2015	Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio.	sulforaphane	31-34	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
26296464-5	2015	Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio.	sulforaphane	31-34	cytochrome c, somatic	Homo sapiens	183-195
26296464-5	2015	Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio.	sulforaphane	31-34	caspase 3	Homo sapiens	234-243
26296464-5	2015	Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio.	sulforaphane	31-34	BCL2 apoptosis regulator	Homo sapiens	266-271
26296464-5	2015	Western blot demonstrated that SFN-induced apoptosis was mediated via the mitochondrial apoptosis pathway based on increased cleavage of poly-ADP-ribose-polymerase (PARP), release of cytochrome c into the cytoplasm, and activation of caspase-3, as well as decreased Bcl-2/Bax ratio.	sulforaphane	31-34	BCL2 associated X, apoptosis regulator	Homo sapiens	272-275
26296464-7	2015	Therefore, our findings clarified that SFN could induce 3T3-L1 adipocyte apoptosis via down-regulation of the Akt/p70s6k1/Bad pathway and up-regulation of the ERK pathway, suggesting SFN may be a promising agent for the treatment or prevention of obesity.	sulforaphane	39-42	AKT serine/threonine kinase 1	Homo sapiens	110-113
26296464-7	2015	Therefore, our findings clarified that SFN could induce 3T3-L1 adipocyte apoptosis via down-regulation of the Akt/p70s6k1/Bad pathway and up-regulation of the ERK pathway, suggesting SFN may be a promising agent for the treatment or prevention of obesity.	sulforaphane	39-42	mitogen-activated protein kinase 1	Homo sapiens	159-162
26958603-0	2015	Differential expression patterns of Nqo1, AKR1B8 and Ho-1 in the liver and small intestine of C57BL/6 mice treated with sulforaphane.	sulforaphane	120-132	aldo-keto reductase family 1, member B8	Mus musculus	42-48
26958603-0	2015	Differential expression patterns of Nqo1, AKR1B8 and Ho-1 in the liver and small intestine of C57BL/6 mice treated with sulforaphane.	sulforaphane	120-132	heme oxygenase 1	Mus musculus	53-57
26958603-3	2015	This dataset reports the histological changes of Nqo1, AKR1B8, and Ho-1 in wild-type (WT) and Nrf2 (-/-) mice induced by SFN.	sulforaphane	121-124	NAD(P)H dehydrogenase, quinone 1	Mus musculus	49-53
26958603-3	2015	This dataset reports the histological changes of Nqo1, AKR1B8, and Ho-1 in wild-type (WT) and Nrf2 (-/-) mice induced by SFN.	sulforaphane	121-124	aldo-keto reductase family 1, member B8	Mus musculus	55-61
26958603-3	2015	This dataset reports the histological changes of Nqo1, AKR1B8, and Ho-1 in wild-type (WT) and Nrf2 (-/-) mice induced by SFN.	sulforaphane	121-124	heme oxygenase 1	Mus musculus	67-71
26958603-3	2015	This dataset reports the histological changes of Nqo1, AKR1B8, and Ho-1 in wild-type (WT) and Nrf2 (-/-) mice induced by SFN.	sulforaphane	121-124	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
26958603-4	2015	The mice were given a 25 mg/kg single oral dose of SFN for 24 h and 48 h. Immunohistochemistry revealed that, in the liver from WT mice, SFN increased Nqo1 staining in hepatocytes with slight higher staining in the pericentral region.	sulforaphane	51-54	NAD(P)H dehydrogenase, quinone 1	Mus musculus	151-155
26054233-0	2015	S6K1 controls autophagosome maturation in autophagy induced by sulforaphane or serum deprivation.	sulforaphane	63-75	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	0-4
26054233-5	2015	Our results indicate that constitutively active S6K1 decreases the level of LC3 processing and foci formation by autophagosomal vacuoles in cells treated with sulforaphane.	sulforaphane	159-171	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	48-52
26054233-5	2015	Our results indicate that constitutively active S6K1 decreases the level of LC3 processing and foci formation by autophagosomal vacuoles in cells treated with sulforaphane.	sulforaphane	159-171	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	76-79
26054233-6	2015	On the other hand, presence of S6K1 is necessary for autophagosome maturation under conditions of autophagy induced by either sulforaphane or serum deprivation.	sulforaphane	126-138	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	31-35
26402917-6	2015	SFN induced a pro-oxidant effect characterized by depletion of intracellular reduced glutathione during short term exposure (3-6 h), followed by up-regulation of antioxidant enzymes and glutathione levels at 24 h. SFN also caused Nrf2 translocation into the nucleus, up-regulation of antioxidant enzymes and autophagy.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	230-234
26060322-8	2015	SF levels of both cathepsins correlated with DAS28 and CRP in ACPA- and RF-positive but not in seronegative patients.	sulforaphane	0-2	C-reactive protein	Homo sapiens	55-58
26060322-8	2015	SF levels of both cathepsins correlated with DAS28 and CRP in ACPA- and RF-positive but not in seronegative patients.	sulforaphane	0-2	proteinase 3	Homo sapiens	62-66
26402917-6	2015	SFN induced a pro-oxidant effect characterized by depletion of intracellular reduced glutathione during short term exposure (3-6 h), followed by up-regulation of antioxidant enzymes and glutathione levels at 24 h. SFN also caused Nrf2 translocation into the nucleus, up-regulation of antioxidant enzymes and autophagy.	sulforaphane	214-217	nuclear factor, erythroid derived 2, like 2	Mus musculus	230-234
26402917-11	2015	In conclusion, SFN attenuated the cytotoxicity of CdSe QDs in both human hepatocytes and in the mouse liver, and this protection was associated with the induction of Nrf2 pathway and autophagy.	sulforaphane	15-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
26388957-0	2015	Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.	sulforaphane	88-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
26388957-1	2015	BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity.	sulforaphane	30-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-128
26388957-8	2015	HDAC3 knockdown in human colon cancer cells recapitulated the effects of SFN on p16 induction.	sulforaphane	73-76	histone deacetylase 3	Homo sapiens	0-5
26388957-1	2015	BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity.	sulforaphane	30-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
26388957-8	2015	HDAC3 knockdown in human colon cancer cells recapitulated the effects of SFN on p16 induction.	sulforaphane	73-76	cyclin dependent kinase inhibitor 2A	Homo sapiens	80-83
26388957-1	2015	BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity.	sulforaphane	30-42	histone deacetylase 9	Homo sapiens	198-202
26388957-1	2015	BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity.	sulforaphane	44-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-128
26388957-1	2015	BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity.	sulforaphane	44-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
26388957-1	2015	BACKGROUND: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity.	sulforaphane	44-47	histone deacetylase 9	Homo sapiens	198-202
26369337-0	2015	Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
26369337-6	2015	Moreover, in individuals in whom the FEV1 response to MCh challenge decreased after sulforaphane administration, i.e., sulforaphane was protective, the activities of Nrf2-regulated antioxidant and anti-inflammatory genes decreased.	sulforaphane	84-96	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
25708189-8	2015	Therefore, it is important to look for compounds that cause a selective activation of Nrf2 particularly natural substances such as curcumin, sulforaphane, or extracts from the broccoli leaves without side effects.	sulforaphane	141-153	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
25991372-0	2015	Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/beta-catenin signaling in glioblastoma.	sulforaphane	0-12	microRNA 21	Homo sapiens	83-89
25991372-0	2015	Sulforaphane enhances temozolomide-induced apoptosis because of down-regulation of miR-21 via Wnt/beta-catenin signaling in glioblastoma.	sulforaphane	0-12	catenin beta 1	Homo sapiens	98-110
25991372-7	2015	In conclusion, SFN effectively enhances TMZ-induced apoptosis by inhibiting miR-21 via Wnt/beta-catenin signaling in GBM cells.	sulforaphane	15-18	microRNA 21	Homo sapiens	76-82
25991372-7	2015	In conclusion, SFN effectively enhances TMZ-induced apoptosis by inhibiting miR-21 via Wnt/beta-catenin signaling in GBM cells.	sulforaphane	15-18	catenin beta 1	Homo sapiens	91-103
25991372-9	2015	Our studies indicate that sulforaphane (SFN) enhances temozolomide (TMZ)-induced apoptosis because of down-regulation of miR-21 through Wnt/beta-catenin signaling in glioblastoma (GBM) cells.	sulforaphane	26-38	microRNA 21	Homo sapiens	121-127
25991372-9	2015	Our studies indicate that sulforaphane (SFN) enhances temozolomide (TMZ)-induced apoptosis because of down-regulation of miR-21 through Wnt/beta-catenin signaling in glioblastoma (GBM) cells.	sulforaphane	26-38	catenin beta 1	Homo sapiens	140-152
25991372-9	2015	Our studies indicate that sulforaphane (SFN) enhances temozolomide (TMZ)-induced apoptosis because of down-regulation of miR-21 through Wnt/beta-catenin signaling in glioblastoma (GBM) cells.	sulforaphane	40-43	microRNA 21	Homo sapiens	121-127
25991372-9	2015	Our studies indicate that sulforaphane (SFN) enhances temozolomide (TMZ)-induced apoptosis because of down-regulation of miR-21 through Wnt/beta-catenin signaling in glioblastoma (GBM) cells.	sulforaphane	40-43	catenin beta 1	Homo sapiens	140-152
26165427-7	2015	It has been demonstrated that natural compounds derived from plants, vegetables, fungi and micronutrients (such as curcumin, sulforaphane, resveratrol and vitamin D among others) can activate Nrf2 and, thus, promote antioxidant pathways to mitigate oxidative stress and hyperglycemic damage.	sulforaphane	125-137	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
26025579-10	2015	Together, our results demonstrate for the first time that the Nrf2 inducer, SFN, has the potential to provide protection against DOX-mediated cardiotoxicity.	sulforaphane	76-79	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
26134113-0	2015	Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	50-56
26134113-0	2015	Sulforaphane inhibits invasion by phosphorylating ERK1/2 to regulate E-cadherin and CD44v6 in human prostate cancer DU145 cells.	sulforaphane	0-12	cadherin 1	Homo sapiens	69-79
26134113-6	2015	The Transwell assay showed that SFN phosphorylated ERK1/2 in a dose- and time-dependent manner and significantly inhibited cell invasion, while the effect was reduced by the ERK1/2 blocker PD98059 (25 microM).	sulforaphane	32-35	mitogen-activated protein kinase 3	Homo sapiens	51-57
26134113-6	2015	The Transwell assay showed that SFN phosphorylated ERK1/2 in a dose- and time-dependent manner and significantly inhibited cell invasion, while the effect was reduced by the ERK1/2 blocker PD98059 (25 microM).	sulforaphane	32-35	mitogen-activated protein kinase 3	Homo sapiens	174-180
25968598-4	2015	The study was designed to detect a 0.012 log (ng/mL)/month decrease in the log PSA slope in the sulforaphane group from M0 to M6.	sulforaphane	96-108	kallikrein related peptidase 3	Homo sapiens	79-82
25968598-6	2015	For secondary endpoints, median log PSA slopes were consistently lower in sulforaphane-treated men.	sulforaphane	74-86	kallikrein related peptidase 3	Homo sapiens	36-39
25968598-7	2015	Mean changes in PSA levels between M6 and M0 were significantly lower in the sulforaphane group (+0.099 +- 0.341 ng/mL) than in placebo (+0.620 +- 1.417 ng/mL; P = 0.0433).	sulforaphane	77-89	kallikrein related peptidase 3	Homo sapiens	16-19
25968598-8	2015	PSA doubling time was 86% longer in the sulforaphane than in the placebo group (28.9 and 15.5 months, respectively).	sulforaphane	40-52	kallikrein related peptidase 3	Homo sapiens	0-3
25968598-9	2015	PSA increases >20% at M6 were significantly greater in the placebo group (71.8%) than in the sulforaphane group (44.4%); P = 0.0163.	sulforaphane	96-108	kallikrein related peptidase 3	Homo sapiens	0-3
25860202-16	2015	Sulforaphane increased haptoglobin, a chelator of cell-free hemoglobin.	sulforaphane	0-12	haptoglobin	Rattus norvegicus	23-34
25557231-7	2015	Co-treatment of cells with hydrogen peroxide and N-acetylcysteine or the Nrf2 inducer sulforaphane reduced hydrogen peroxide-induced damage in a similar fashion to baicalein, while the Nrf2 inhibitor retinoic acid blocked the protective effect of baicalein.	sulforaphane	86-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
25557231-7	2015	Co-treatment of cells with hydrogen peroxide and N-acetylcysteine or the Nrf2 inducer sulforaphane reduced hydrogen peroxide-induced damage in a similar fashion to baicalein, while the Nrf2 inhibitor retinoic acid blocked the protective effect of baicalein.	sulforaphane	86-98	nuclear factor, erythroid derived 2, like 2	Mus musculus	185-189
25557231-8	2015	Silencing Nrf2 also inhibited the protective effects of baicalein, sulforaphane, and N-acetylcysteine and resulted in high ROS levels, suggesting ROS elimination was mediated by Nrf2.	sulforaphane	67-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	10-14
26013831-0	2015	Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway.	sulforaphane	0-12	dystrophin, muscular dystrophy	Mus musculus	47-57
26013831-0	2015	Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-103
26013831-0	2015	Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-109
26013831-0	2015	Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-kappaB Signaling Pathway.	sulforaphane	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
26013831-4	2015	To determine whether Nrf2 may counteract inflammation in dystrophic muscle, we treated 4-week-old male mdx mice with the Nrf2 activator sulforaphane (SFN) by gavage (2 mg/kg of body weight/day) for 4 weeks.	sulforaphane	136-148	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
26013831-4	2015	To determine whether Nrf2 may counteract inflammation in dystrophic muscle, we treated 4-week-old male mdx mice with the Nrf2 activator sulforaphane (SFN) by gavage (2 mg/kg of body weight/day) for 4 weeks.	sulforaphane	150-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
26013831-8	2015	Collectively, these results show that SFN-induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting the NF-kappaB signaling pathway.	sulforaphane	38-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-54
26013831-8	2015	Collectively, these results show that SFN-induced Nrf2 can alleviate muscle inflammation in mdx mice by inhibiting the NF-kappaB signaling pathway.	sulforaphane	38-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
25981546-0	2015	Insights into the binding sites of sulforaphane on insulin studied by electrospray ionization mass spectrometry.	sulforaphane	35-47	insulin	Homo sapiens	51-58
25936432-4	2015	The results revealed that the pre-treatment of H9c2 rat myoblasts with sulforaphane decreased the apoptotic cell number (as shown by trypan blue exclusion assay) and the expression of pro-apoptotic proteins (Bax, caspase-3 and cytochrome c; as shown by western blot analysis and immunostaining), as well as the doxorubicin-induced increase in mitochondrial membrane potential (measured by JC-1 assay).	sulforaphane	71-83	BCL2 associated X, apoptosis regulator	Rattus norvegicus	208-211
25936432-4	2015	The results revealed that the pre-treatment of H9c2 rat myoblasts with sulforaphane decreased the apoptotic cell number (as shown by trypan blue exclusion assay) and the expression of pro-apoptotic proteins (Bax, caspase-3 and cytochrome c; as shown by western blot analysis and immunostaining), as well as the doxorubicin-induced increase in mitochondrial membrane potential (measured by JC-1 assay).	sulforaphane	71-83	caspase 3	Rattus norvegicus	213-222
25936432-5	2015	Furthermore, sulforaphane increased the mRNA and protein expression of heme oxygenase-1 (HO-1, measured by RT-qPCR), which consequently reduced the levels of reactive oxygen species (ROS, measured using MitoSOX Red reagent) in the mitochondria which were induced by doxorubicin.	sulforaphane	13-25	heme oxygenase 1	Rattus norvegicus	71-87
25936432-5	2015	Furthermore, sulforaphane increased the mRNA and protein expression of heme oxygenase-1 (HO-1, measured by RT-qPCR), which consequently reduced the levels of reactive oxygen species (ROS, measured using MitoSOX Red reagent) in the mitochondria which were induced by doxorubicin.	sulforaphane	13-25	heme oxygenase 1	Rattus norvegicus	89-93
25936432-6	2015	The cardioprotective effects of sulforaphane were found to be mediated by the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, which in turn mediates the induction of HO-1.	sulforaphane	32-44	Kelch-like ECH-associated protein 1	Rattus norvegicus	96-131
25936432-6	2015	The cardioprotective effects of sulforaphane were found to be mediated by the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, which in turn mediates the induction of HO-1.	sulforaphane	32-44	Kelch-like ECH-associated protein 1	Rattus norvegicus	133-138
25936432-6	2015	The cardioprotective effects of sulforaphane were found to be mediated by the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, which in turn mediates the induction of HO-1.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-162
25936432-6	2015	The cardioprotective effects of sulforaphane were found to be mediated by the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, which in turn mediates the induction of HO-1.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	164-168
25936432-6	2015	The cardioprotective effects of sulforaphane were found to be mediated by the activation of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor-2 (Nrf2)/antioxidant-responsive element (ARE) pathway, which in turn mediates the induction of HO-1.	sulforaphane	32-44	heme oxygenase 1	Rattus norvegicus	256-260
25936432-7	2015	Taken together, the findings of this study demonstrate that sulforaphane prevents doxorubicin-induced oxidative stress and cell death in H9c2 cells through the induction of HO-1 expression.	sulforaphane	60-72	heme oxygenase 1	Rattus norvegicus	173-177
25955133-5	2015	Using the cell-based reporter assay, we identified several oncogenic pathways modulated by sulforaphane in hypoxia by activating anticancer responses (p53, ARE, IRF-1, Pax-6 and XRE) and suppressing responses supporting tumor progression (AP-1 and HIF-1).	sulforaphane	91-103	tumor protein p53	Homo sapiens	151-154
25955133-5	2015	Using the cell-based reporter assay, we identified several oncogenic pathways modulated by sulforaphane in hypoxia by activating anticancer responses (p53, ARE, IRF-1, Pax-6 and XRE) and suppressing responses supporting tumor progression (AP-1 and HIF-1).	sulforaphane	91-103	interferon regulatory factor 1	Homo sapiens	161-166
25955133-5	2015	Using the cell-based reporter assay, we identified several oncogenic pathways modulated by sulforaphane in hypoxia by activating anticancer responses (p53, ARE, IRF-1, Pax-6 and XRE) and suppressing responses supporting tumor progression (AP-1 and HIF-1).	sulforaphane	91-103	paired box 6	Homo sapiens	168-173
25955133-5	2015	Using the cell-based reporter assay, we identified several oncogenic pathways modulated by sulforaphane in hypoxia by activating anticancer responses (p53, ARE, IRF-1, Pax-6 and XRE) and suppressing responses supporting tumor progression (AP-1 and HIF-1).	sulforaphane	91-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	239-243
25955133-5	2015	Using the cell-based reporter assay, we identified several oncogenic pathways modulated by sulforaphane in hypoxia by activating anticancer responses (p53, ARE, IRF-1, Pax-6 and XRE) and suppressing responses supporting tumor progression (AP-1 and HIF-1).	sulforaphane	91-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	248-253
25955133-6	2015	We further showed that sulforaphane decreases the level of HIF-1alpha protein without affecting its transcription and stability.	sulforaphane	23-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
26094214-2	2015	Sulforaphane (SFN), a representative dietary isothiocyanate, has previously been shown to up-regulate antioxidant enzymes such as selenium (Se)-dependent thioredoxin reductase-1 (TrxR-1) in many tumor cell lines.	sulforaphane	0-12	thioredoxin reductase 1	Homo sapiens	154-177
26094214-2	2015	Sulforaphane (SFN), a representative dietary isothiocyanate, has previously been shown to up-regulate antioxidant enzymes such as selenium (Se)-dependent thioredoxin reductase-1 (TrxR-1) in many tumor cell lines.	sulforaphane	0-12	thioredoxin reductase 1	Homo sapiens	179-185
26094214-2	2015	Sulforaphane (SFN), a representative dietary isothiocyanate, has previously been shown to up-regulate antioxidant enzymes such as selenium (Se)-dependent thioredoxin reductase-1 (TrxR-1) in many tumor cell lines.	sulforaphane	14-17	thioredoxin reductase 1	Homo sapiens	154-177
26094214-2	2015	Sulforaphane (SFN), a representative dietary isothiocyanate, has previously been shown to up-regulate antioxidant enzymes such as selenium (Se)-dependent thioredoxin reductase-1 (TrxR-1) in many tumor cell lines.	sulforaphane	14-17	thioredoxin reductase 1	Homo sapiens	179-185
26094214-3	2015	In the present study, we hypothesized that a combination of SFN and Se would have a synergistic effect on the up-regulation of TrxR-1 and the protection against oxidative damage in the normal colonic cell line CCD841.	sulforaphane	60-63	thioredoxin reductase 1	Homo sapiens	127-133
26094214-7	2015	This suggests that both TrxR-1 and Nrf2 are important in SFN-mediated protection against free radical-induced cell death.	sulforaphane	57-60	thioredoxin reductase 1	Homo sapiens	24-30
26094214-7	2015	This suggests that both TrxR-1 and Nrf2 are important in SFN-mediated protection against free radical-induced cell death.	sulforaphane	57-60	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
26094214-8	2015	Moreover, flow cytometric analysis showed that TrxR-1 and Nrf2 were involved in SFN-mediated protection against H2O2-induced apoptosis.	sulforaphane	80-83	thioredoxin reductase 1	Homo sapiens	47-53
26094214-8	2015	Moreover, flow cytometric analysis showed that TrxR-1 and Nrf2 were involved in SFN-mediated protection against H2O2-induced apoptosis.	sulforaphane	80-83	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
26094214-9	2015	In summary, SFN activates the Nrf2 signaling pathway and protects against H2O2-mediated oxidative damage in normal colonic cells.	sulforaphane	12-15	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
26094214-10	2015	Combined SFN and Se treatment resulted in a synergistic up-regulation of TrxR-1 that in part contributed to the enhanced protection against free radical-mediated cell death provided by the cotreatment.	sulforaphane	9-12	thioredoxin reductase 1	Homo sapiens	73-79
25159108-11	2015	Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.	sulforaphane	15-27	NAD(P)H quinone dehydrogenase 1	Homo sapiens	38-71
25159108-11	2015	Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.	sulforaphane	15-27	NAD(P)H quinone dehydrogenase 1	Homo sapiens	73-77
25159108-11	2015	Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.	sulforaphane	15-27	glutathione S-transferase alpha 1	Homo sapiens	83-111
25159108-11	2015	Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.	sulforaphane	15-27	glutathione S-transferase alpha 1	Homo sapiens	113-118
25159108-11	2015	Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.	sulforaphane	15-27	catechol-O-methyltransferase	Homo sapiens	193-197
25159108-11	2015	Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.	sulforaphane	15-27	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	202-221
25981546-2	2015	A more detailed knowledge on the direct interaction of SFN with insulin and its binding sites is necessary for better understanding the role of SFN on diabetes.	sulforaphane	55-58	insulin	Homo sapiens	64-71
25981546-2	2015	A more detailed knowledge on the direct interaction of SFN with insulin and its binding sites is necessary for better understanding the role of SFN on diabetes.	sulforaphane	144-147	insulin	Homo sapiens	64-71
25981546-6	2015	The nature of binding of SFN and its binding sites with insulin were evaluated by LC/MS data.	sulforaphane	25-28	insulin	Homo sapiens	56-63
25981546-8	2015	LC/MS analysis revealed that the [Insulin+SFN] complexes were due to covalent binding of SFN at two different sites.	sulforaphane	89-92	insulin	Homo sapiens	34-41
25981546-9	2015	The in-source fragmentation experiments revealed that the SFN is binding to the NH2 groups of N-terminal amino acids of A and B chains of insulin.	sulforaphane	58-61	insulin	Homo sapiens	138-145
25981546-10	2015	Further study of SFN with insulin reduced with dithiothreitol (DTT) showed exclusive modification of cysteines with SFN.	sulforaphane	17-20	insulin	Homo sapiens	26-33
25981546-10	2015	Further study of SFN with insulin reduced with dithiothreitol (DTT) showed exclusive modification of cysteines with SFN.	sulforaphane	116-119	insulin	Homo sapiens	26-33
25981546-11	2015	CONCLUSIONS: The interaction of SFN was studied with insulin using ESI-MS. SFN is found to bind covalently with the free NH2 group of the N-terminal of the A and B chains of insulin.	sulforaphane	32-35	insulin	Homo sapiens	53-60
25981546-11	2015	CONCLUSIONS: The interaction of SFN was studied with insulin using ESI-MS. SFN is found to bind covalently with the free NH2 group of the N-terminal of the A and B chains of insulin.	sulforaphane	32-35	insulin	Homo sapiens	174-181
25981546-11	2015	CONCLUSIONS: The interaction of SFN was studied with insulin using ESI-MS. SFN is found to bind covalently with the free NH2 group of the N-terminal of the A and B chains of insulin.	sulforaphane	75-78	insulin	Homo sapiens	53-60
25981546-11	2015	CONCLUSIONS: The interaction of SFN was studied with insulin using ESI-MS. SFN is found to bind covalently with the free NH2 group of the N-terminal of the A and B chains of insulin.	sulforaphane	75-78	insulin	Homo sapiens	174-181
25933243-7	2015	Sulforaphane modulated brain-derived neurotrophic factor and its pathway, whose dysregulation is related to AD development.	sulforaphane	0-12	brain derived neurotrophic factor	Homo sapiens	23-56
26107664-3	2015	Sulforaphane (SFN), an isothiocyanate derived from broccoli, is a potent activator of the transcription factor Nrf2, which plays a central role in the inducible expressions of many cytoprotective genes in response to oxidative stress.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
26107664-3	2015	Sulforaphane (SFN), an isothiocyanate derived from broccoli, is a potent activator of the transcription factor Nrf2, which plays a central role in the inducible expressions of many cytoprotective genes in response to oxidative stress.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
25818464-3	2015	This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity in vitro and in vivo.	sulforaphane	32-44	heme oxygenase 1	Mus musculus	57-61
25933243-5	2015	The data demonstrated that sulforaphane protects cells against glycative damage by inhibiting activation of the caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress, and increasing intracellular glutathione levels.	sulforaphane	27-39	caspase 3	Homo sapiens	112-121
25933243-5	2015	The data demonstrated that sulforaphane protects cells against glycative damage by inhibiting activation of the caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress, and increasing intracellular glutathione levels.	sulforaphane	27-39	mitogen-activated protein kinase 3	Homo sapiens	162-166
25933243-5	2015	The data demonstrated that sulforaphane protects cells against glycative damage by inhibiting activation of the caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress, and increasing intracellular glutathione levels.	sulforaphane	27-39	mitogen-activated protein kinase 3	Homo sapiens	187-193
25933243-5	2015	The data demonstrated that sulforaphane protects cells against glycative damage by inhibiting activation of the caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress, and increasing intracellular glutathione levels.	sulforaphane	27-39	mitogen-activated protein kinase 8	Homo sapiens	195-198
25933243-5	2015	The data demonstrated that sulforaphane protects cells against glycative damage by inhibiting activation of the caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress, and increasing intracellular glutathione levels.	sulforaphane	27-39	mitogen-activated protein kinase 1	Homo sapiens	204-207
26036303-0	2015	Sulforaphane attenuates EGFR signaling in NSCLC cells.	sulforaphane	0-12	epidermal growth factor receptor	Homo sapiens	24-28
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	65-77	heat shock protein 90 alpha family class A member 1	Homo sapiens	112-117
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	65-77	epidermal growth factor receptor	Homo sapiens	169-173
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	140-152	epidermal growth factor receptor	Homo sapiens	3-7
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	140-152	heat shock protein 90 alpha family class A member 1	Homo sapiens	31-52
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	140-152	heat shock protein 90 alpha family class A member 1	Homo sapiens	54-59
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	140-152	heat shock protein 90 alpha family class A member 1	Homo sapiens	112-117
26036303-5	2015	As EGFR is a client protein of heat-shock protein 90 (HSP90) and sulforaphane is known to functionally regulate HSP90, we hypothesized that sulforaphane could attenuate EGFR-related signaling and potentially be used to treat NSCLC.	sulforaphane	140-152	epidermal growth factor receptor	Homo sapiens	169-173
26036303-7	2015	The sensitivity of NSCLC cells to sulforaphane appeared to positively correlate with the inhibition of EGFR-related signaling, which was attributed to the increased proteasomal degradation of EGFR.	sulforaphane	34-46	epidermal growth factor receptor	Homo sapiens	103-107
26036303-7	2015	The sensitivity of NSCLC cells to sulforaphane appeared to positively correlate with the inhibition of EGFR-related signaling, which was attributed to the increased proteasomal degradation of EGFR.	sulforaphane	34-46	epidermal growth factor receptor	Homo sapiens	192-196
26036303-8	2015	Combined treatment of NSCLC cells with sulforaphane plus another HSP90 inhibitor (17-AAG) enhanced the inhibition of EGFR-related signaling both in vitro and in vivo.	sulforaphane	39-51	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
26036303-8	2015	Combined treatment of NSCLC cells with sulforaphane plus another HSP90 inhibitor (17-AAG) enhanced the inhibition of EGFR-related signaling both in vitro and in vivo.	sulforaphane	39-51	N-methylpurine DNA glycosylase	Homo sapiens	85-88
26036303-8	2015	Combined treatment of NSCLC cells with sulforaphane plus another HSP90 inhibitor (17-AAG) enhanced the inhibition of EGFR-related signaling both in vitro and in vivo.	sulforaphane	39-51	epidermal growth factor receptor	Homo sapiens	117-121
26036303-9	2015	CONCLUSIONS: We have shown that sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.	sulforaphane	32-44	epidermal growth factor receptor	Homo sapiens	80-84
26036303-9	2015	CONCLUSIONS: We have shown that sulforaphane is a novel inhibitory modulator of EGFR expression and is effective in inhibiting the tumor growth of EGFR-TKI-resistant NSCLC cells.	sulforaphane	32-44	epidermal growth factor receptor	Homo sapiens	147-151
25364882-7	2015	Furthermore, sulforaphane mediates a number of anticancer pathways, including the activation of apoptosis, induction of cell cycle arrest, and inhibition of NFkappaB.	sulforaphane	13-25	nuclear factor kappa B subunit 1	Homo sapiens	157-165
26008201-12	2015	SFN protected the injury of vascular endothelial cell by LPC by enhancing anti-oxidative capabilities mediated by Nrf-2 translocation.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	114-119
25804610-7	2015	In healthy human subjects, topical applications of extracts delivering the Nrf2 activator sulforaphane reduced the degree of solar-simulated UV radiation-induced skin erythema, a quantifiable surrogate endpoint for cutaneous damage and skin cancer risk.	sulforaphane	90-102	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
25818464-3	2015	This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity in vitro and in vivo.	sulforaphane	46-49	heme oxygenase 1	Mus musculus	57-61
25724107-0	2015	Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.	sulforaphane	0-12	glycogen synthase kinase 3 beta	Rattus norvegicus	71-81
25795629-11	2015	SFN and EGCG significantly, but catechin weakly, inhibited RANKL-mediated osteoclastogenesis in vitro.	sulforaphane	0-3	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	59-64
25724107-0	2015	Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.	sulforaphane	0-12	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	82-85
25724107-8	2015	Taken together, our findings suggested that SFN ameliorated experimental diabetic nephropathy, at least in part, via GSK3beta/Fyn/Nrf2 signaling pathway.	sulforaphane	44-47	glycogen synthase kinase 3 beta	Rattus norvegicus	117-125
25724107-8	2015	Taken together, our findings suggested that SFN ameliorated experimental diabetic nephropathy, at least in part, via GSK3beta/Fyn/Nrf2 signaling pathway.	sulforaphane	44-47	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	126-129
25724107-0	2015	Sulforaphane attenuation of experimental diabetic nephropathy involves GSK-3 beta/Fyn/Nrf2 signaling pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-90
25724107-8	2015	Taken together, our findings suggested that SFN ameliorated experimental diabetic nephropathy, at least in part, via GSK3beta/Fyn/Nrf2 signaling pathway.	sulforaphane	44-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134
25724107-4	2015	SFN treatment obviously prevented the increase in urine albumin excretion, matrix expansion, transforming growth factor-beta1 expression, fibronectin and type IV collagen deposition in the diabetic kidney.	sulforaphane	0-3	transforming growth factor, beta 1	Rattus norvegicus	93-125
25724107-4	2015	SFN treatment obviously prevented the increase in urine albumin excretion, matrix expansion, transforming growth factor-beta1 expression, fibronectin and type IV collagen deposition in the diabetic kidney.	sulforaphane	0-3	fibronectin 1	Rattus norvegicus	138-149
25724107-5	2015	Simultaneously, the level of 8-oxo-deoxyguanosine, an indicator of oxidative damage, was markedly lowered in SFN-treated diabetic rats, together with a significant reduction in activity of the GSK-3beta/Fyn axis and an evident activation of Nrf2 signaling.	sulforaphane	109-112	glycogen synthase kinase 3 beta	Rattus norvegicus	193-202
25724107-5	2015	Simultaneously, the level of 8-oxo-deoxyguanosine, an indicator of oxidative damage, was markedly lowered in SFN-treated diabetic rats, together with a significant reduction in activity of the GSK-3beta/Fyn axis and an evident activation of Nrf2 signaling.	sulforaphane	109-112	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	203-206
25724107-5	2015	Simultaneously, the level of 8-oxo-deoxyguanosine, an indicator of oxidative damage, was markedly lowered in SFN-treated diabetic rats, together with a significant reduction in activity of the GSK-3beta/Fyn axis and an evident activation of Nrf2 signaling.	sulforaphane	109-112	NFE2 like bZIP transcription factor 2	Rattus norvegicus	241-245
25724107-6	2015	Similarly, antifibrotic effects of SFN, parallel to enhanced inhibitory Ser9-phosphorylation of GSK3beta and Fyn/Nrf2 nuclear export/import, were observed in the cultured rat mesangial cells (RMC) exposed to high glucose.	sulforaphane	35-38	glycogen synthase kinase 3 beta	Rattus norvegicus	96-104
25724107-6	2015	Similarly, antifibrotic effects of SFN, parallel to enhanced inhibitory Ser9-phosphorylation of GSK3beta and Fyn/Nrf2 nuclear export/import, were observed in the cultured rat mesangial cells (RMC) exposed to high glucose.	sulforaphane	35-38	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	109-112
25724107-6	2015	Similarly, antifibrotic effects of SFN, parallel to enhanced inhibitory Ser9-phosphorylation of GSK3beta and Fyn/Nrf2 nuclear export/import, were observed in the cultured rat mesangial cells (RMC) exposed to high glucose.	sulforaphane	35-38	NFE2 like bZIP transcription factor 2	Rattus norvegicus	113-117
25724107-7	2015	The salutary effects of SFN on high-glucose-stimulated RMC were abolished by overexpression of GSK3beta while being rescued by lithium chloride, a well-known GSK3beta inhibitor.	sulforaphane	24-27	glycogen synthase kinase 3 beta	Rattus norvegicus	95-103
25724107-7	2015	The salutary effects of SFN on high-glucose-stimulated RMC were abolished by overexpression of GSK3beta while being rescued by lithium chloride, a well-known GSK3beta inhibitor.	sulforaphane	24-27	glycogen synthase kinase 3 beta	Rattus norvegicus	158-166
25712054-7	2015	A similar trend was discernible in the tumors from SFN-treated TRAMP mice compared with those of control mice, but the difference was not significant.	sulforaphane	51-54	tumor necrosis factor receptor superfamily, member 25	Mus musculus	63-68
25842137-4	2015	In this paper, we report HAp nanorod crystal synthesized successfully by a biomimetic method using calcium chloride and ammonium dihydrogen phosphate as reagents in the presence of silk fibroin/sodium alginate (SF/SA) fibrous hydrogels.	sulforaphane	211-213	reticulon 3	Homo sapiens	25-28
25725373-2	2015	We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERalpha expression in ERalpha-negative MDA-MB-231 cells.	sulforaphane	127-139	estrogen receptor 1	Homo sapiens	199-206
25725373-2	2015	We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERalpha expression in ERalpha-negative MDA-MB-231 cells.	sulforaphane	127-139	estrogen receptor 1	Homo sapiens	221-228
25725373-2	2015	We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERalpha expression in ERalpha-negative MDA-MB-231 cells.	sulforaphane	141-144	estrogen receptor 1	Homo sapiens	199-206
25725373-2	2015	We have shown previously that the combinations of green tea polyphenols (GTPs), a dietary DNA methyltransferase inhibitor, and sulforaphane (SFN), a dietary histone deacetylase inhibitor, reactivate ERalpha expression in ERalpha-negative MDA-MB-231 cells.	sulforaphane	141-144	estrogen receptor 1	Homo sapiens	221-228
25725373-4	2015	We found that the treatment of MDA-MB-231 cells with the combinations of GTPs and SFN leads to the reactivation of silenced TSGs such as p21(CIP1/WAF1) and KLOTHO through active chromatin modifications.	sulforaphane	82-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-140
25725373-4	2015	We found that the treatment of MDA-MB-231 cells with the combinations of GTPs and SFN leads to the reactivation of silenced TSGs such as p21(CIP1/WAF1) and KLOTHO through active chromatin modifications.	sulforaphane	82-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-145
25725373-4	2015	We found that the treatment of MDA-MB-231 cells with the combinations of GTPs and SFN leads to the reactivation of silenced TSGs such as p21(CIP1/WAF1) and KLOTHO through active chromatin modifications.	sulforaphane	82-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-150
25725373-4	2015	We found that the treatment of MDA-MB-231 cells with the combinations of GTPs and SFN leads to the reactivation of silenced TSGs such as p21(CIP1/WAF1) and KLOTHO through active chromatin modifications.	sulforaphane	82-85	klotho	Homo sapiens	156-162
25725373-5	2015	Further, GTPs- and SFN-mediated reactivation of TSGs was, at least in part, dependent on ERalpha reactivation in ERalpha-negative MDA-MB-231 cells.	sulforaphane	19-22	estrogen receptor 1	Homo sapiens	89-96
25725373-5	2015	Further, GTPs- and SFN-mediated reactivation of TSGs was, at least in part, dependent on ERalpha reactivation in ERalpha-negative MDA-MB-231 cells.	sulforaphane	19-22	estrogen receptor 1	Homo sapiens	113-120
25259561-5	2015	The natural antioxidant sulforaphane (SFN) induces nuclear translocation of nuclear factor, erythroid 2-like 2 (Nrf2), a transcription factor that regulates genes with AREs in their promoters, many of which are involved in response to injury.	sulforaphane	24-36	NFE2 like bZIP transcription factor 2	Homo sapiens	76-110
25328080-8	2015	Using autologous blood injection ICH model to measure hematoma resolution, we showed that Nrf2 activator, sulforaphane, injected to animals after the onset of ICH, induced CD36 expression in ICH-affected brain and improved hematoma clearance in rats and wild-type mice, but expectedly not in Nrf2 knockout (KO) mice.	sulforaphane	106-118	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
25328080-8	2015	Using autologous blood injection ICH model to measure hematoma resolution, we showed that Nrf2 activator, sulforaphane, injected to animals after the onset of ICH, induced CD36 expression in ICH-affected brain and improved hematoma clearance in rats and wild-type mice, but expectedly not in Nrf2 knockout (KO) mice.	sulforaphane	106-118	nuclear factor, erythroid derived 2, like 2	Mus musculus	292-296
25793534-4	2015	SFN was found to inhibit the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.	sulforaphane	0-3	histone deacetylase 6	Homo sapiens	60-65
25793534-4	2015	SFN was found to inhibit the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.	sulforaphane	0-3	histone deacetylase 10	Homo sapiens	67-73
25793534-4	2015	SFN was found to inhibit the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.	sulforaphane	0-3	DNA methyltransferase 3 alpha	Homo sapiens	78-107
25793534-4	2015	SFN was found to inhibit the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.	sulforaphane	0-3	DNA methyltransferase 1	Homo sapiens	165-170
25788192-0	2015	Sulforaphane reduces apoptosis and oncosis along with protecting liver injury-induced ischemic reperfusion by activating the Nrf2/ARE pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
25788192-11	2015	Pre-treatment with SFN could reduce the levels of MDA and MPO in liver tissue and improve the activities of SOD, GSH, GSH-Px, and mitochondrial Na(+)-K(+)-ATPase and Ca(2+)-ATPase in liver tissue.	sulforaphane	19-22	myeloperoxidase	Rattus norvegicus	58-61
25788192-13	2015	CONCLUSIONS: Pre-treatment with SFN could attenuate HIRI via the activation of Nrf2/ARE signaling pathways, ameliorate oxidative stress, and maintain the normal activities of Na(+)-K(+)-ATPase and Ca(2+)-ATPase, thus reducing the occurrence of cell oncosis and apoptosis.	sulforaphane	32-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	79-83
25652350-8	2015	Combinations of low doses of free IBU (250 microM) and SFN (5 microM) reduced cell viability by ~55% (P<0.01), whereas a lower dose of encapsulated IBU-SLN (62.5 microM) and free SFN (5 microM) reduced cell viability by ~80% (P<0.001) for both Panc-1 and MIA PaCa-2 cells.	sulforaphane	55-58	sarcolipin	Homo sapiens	155-158
25721293-0	2015	Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis.	sulforaphane	0-12	killer cell lectin like receptor K1	Homo sapiens	47-52
25721293-1	2015	AIMS: The goal of this study is to investigate the tumor cytotoxic effects of sulforaphane (SFN) and ionizing radiation (IR) as well as their ability to up-regulate natural killer group 2, member D (NKG2D) ligands and modulate the susceptibility of tumor cells to natural killer (NK) cell-mediated killing.	sulforaphane	78-90	killer cell lectin like receptor K1	Homo sapiens	199-204
25721293-6	2015	IR induced an increase in expression of MICA/MICB in MCF7 cells and SFN induced MICA/MICB expression in A549 and MDA-MB-231 cells.	sulforaphane	68-71	MHC class I polypeptide-related sequence A	Homo sapiens	80-84
25721293-6	2015	IR induced an increase in expression of MICA/MICB in MCF7 cells and SFN induced MICA/MICB expression in A549 and MDA-MB-231 cells.	sulforaphane	68-71	MHC class I polypeptide-related sequence B	Homo sapiens	85-89
25721293-8	2015	SFN induced increase in MICA/MICB expression as well as increased susceptibility to NK cell mediated killing was abrogated by N-acetyl cysteine in A549 and MDA-MB-231 cells suggesting a ROS mediated mechanism.	sulforaphane	0-3	MHC class I polypeptide-related sequence A	Homo sapiens	24-28
25721293-8	2015	SFN induced increase in MICA/MICB expression as well as increased susceptibility to NK cell mediated killing was abrogated by N-acetyl cysteine in A549 and MDA-MB-231 cells suggesting a ROS mediated mechanism.	sulforaphane	0-3	MHC class I polypeptide-related sequence B	Homo sapiens	29-33
25259561-5	2015	The natural antioxidant sulforaphane (SFN) induces nuclear translocation of nuclear factor, erythroid 2-like 2 (Nrf2), a transcription factor that regulates genes with AREs in their promoters, many of which are involved in response to injury.	sulforaphane	24-36	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
25259561-5	2015	The natural antioxidant sulforaphane (SFN) induces nuclear translocation of nuclear factor, erythroid 2-like 2 (Nrf2), a transcription factor that regulates genes with AREs in their promoters, many of which are involved in response to injury.	sulforaphane	38-41	NFE2 like bZIP transcription factor 2	Homo sapiens	76-110
25259561-5	2015	The natural antioxidant sulforaphane (SFN) induces nuclear translocation of nuclear factor, erythroid 2-like 2 (Nrf2), a transcription factor that regulates genes with AREs in their promoters, many of which are involved in response to injury.	sulforaphane	38-41	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
25481685-0	2015	Modulation of apoptosis by sulforaphane is associated with PGC-1alpha stimulation and decreased oxidative stress in cardiac myoblasts.	sulforaphane	27-39	PPARG coactivator 1 alpha	Sus scrofa	59-69
25134969-8	2015	A 48-hr treatment of human erythrocytes with sulforaphane (50-100 muM) significantly decreased forward scatter, significantly increased the percentage of annexin V binding cells and significantly increased [Ca(2+)]i.	sulforaphane	45-57	latexin	Homo sapiens	66-69
25134969-9	2015	The effect of sulforaphane (100 muM) on annexin V binding was significantly blunted but not abrogated by the removal of extracellular Ca(2+).	sulforaphane	14-26	latexin	Homo sapiens	32-35
25134969-10	2015	Sulforaphane (100 muM) significantly increased ceramide formation.	sulforaphane	0-12	latexin	Homo sapiens	18-21
25481685-4	2015	The aim of the present study was to investigate whether sulforaphane can modulate oxidative stress, apoptosis, and correlate with PGC-1alpha, a transcriptional cofactor involved in energy metabolism.	sulforaphane	56-68	PPARG coactivator 1 alpha	Sus scrofa	130-140
25481685-6	2015	In cells treated with sulforaphane, cellular viability increased (12 %) and ANP gene expression decreased (46 %) compared to control cells.	sulforaphane	22-34	natriuretic peptides A	Sus scrofa	76-79
25481685-7	2015	Moreover, sulforaphane induced a significant increase in superoxide dismutase (103 %), catalase (101 %), and glutathione S-transferase (72 %) activity, reduced reactive oxygen species levels (15 %) and lipid peroxidation (65 %), as well as stimulated the expression of the cytoprotective enzyme heme oxygenase-1 (4-fold).	sulforaphane	10-22	catalase	Sus scrofa	87-95
25481685-7	2015	Moreover, sulforaphane induced a significant increase in superoxide dismutase (103 %), catalase (101 %), and glutathione S-transferase (72 %) activity, reduced reactive oxygen species levels (15 %) and lipid peroxidation (65 %), as well as stimulated the expression of the cytoprotective enzyme heme oxygenase-1 (4-fold).	sulforaphane	10-22	microsomal glutathione S-transferase 1	Sus scrofa	109-134
25481685-7	2015	Moreover, sulforaphane induced a significant increase in superoxide dismutase (103 %), catalase (101 %), and glutathione S-transferase (72 %) activity, reduced reactive oxygen species levels (15 %) and lipid peroxidation (65 %), as well as stimulated the expression of the cytoprotective enzyme heme oxygenase-1 (4-fold).	sulforaphane	10-22	heme oxygenase 1	Sus scrofa	295-311
25481685-8	2015	Sulforaphane also promoted an increase in the expression of the anti-apoptotic protein Bcl-2 (60 %), decreasing the Bax/Bcl-2 ratio.	sulforaphane	0-12	apoptosis regulator Bcl-2	Sus scrofa	87-92
25481685-8	2015	Sulforaphane also promoted an increase in the expression of the anti-apoptotic protein Bcl-2 (60 %), decreasing the Bax/Bcl-2 ratio.	sulforaphane	0-12	apoptosis regulator BAX	Sus scrofa	116-119
25481685-8	2015	Sulforaphane also promoted an increase in the expression of the anti-apoptotic protein Bcl-2 (60 %), decreasing the Bax/Bcl-2 ratio.	sulforaphane	0-12	apoptosis regulator Bcl-2	Sus scrofa	120-125
25481685-9	2015	Active Caspase 3\7 and p-JNK/JNK were also reduced by sulforaphane, suggesting a reduction in apoptotic signaling.	sulforaphane	54-66	mitogen-activated protein kinase 8	Sus scrofa	25-28
25481685-9	2015	Active Caspase 3\7 and p-JNK/JNK were also reduced by sulforaphane, suggesting a reduction in apoptotic signaling.	sulforaphane	54-66	mitogen-activated protein kinase 8	Sus scrofa	29-32
25481685-11	2015	These results suggest that sulforaphane offers cytoprotection to cardiac cells by activating PGC1-alpha, reducing oxidative stress, and decreasing apoptosis signaling.	sulforaphane	27-39	PPARG coactivator 1 alpha	Sus scrofa	93-103
24849033-9	2015	Conversely, Nrf2 activation and subsequent Gclc increase by Nrf2-activating sulforaphane alleviated the TGFbeta1-stimulated alpha-Sma increase and E-cadherin decrease.	sulforaphane	76-88	NFE2 like bZIP transcription factor 2	Rattus norvegicus	12-16
24849033-9	2015	Conversely, Nrf2 activation and subsequent Gclc increase by Nrf2-activating sulforaphane alleviated the TGFbeta1-stimulated alpha-Sma increase and E-cadherin decrease.	sulforaphane	76-88	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	43-47
24849033-9	2015	Conversely, Nrf2 activation and subsequent Gclc increase by Nrf2-activating sulforaphane alleviated the TGFbeta1-stimulated alpha-Sma increase and E-cadherin decrease.	sulforaphane	76-88	NFE2 like bZIP transcription factor 2	Rattus norvegicus	60-64
24849033-9	2015	Conversely, Nrf2 activation and subsequent Gclc increase by Nrf2-activating sulforaphane alleviated the TGFbeta1-stimulated alpha-Sma increase and E-cadherin decrease.	sulforaphane	76-88	transforming growth factor, beta 1	Rattus norvegicus	104-112
24849033-9	2015	Conversely, Nrf2 activation and subsequent Gclc increase by Nrf2-activating sulforaphane alleviated the TGFbeta1-stimulated alpha-Sma increase and E-cadherin decrease.	sulforaphane	76-88	cadherin 1	Rattus norvegicus	147-157
26583056-7	2015	SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
25332186-0	2015	Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways.	sulforaphane	0-12	GATA binding protein 4	Homo sapiens	58-63
25332186-0	2015	Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways.	sulforaphane	0-12	GATA binding protein 6	Homo sapiens	64-69
25705128-0	2015	Effect of Sulforaphane on NOD2 via NF-kappaB: implications for Crohn"s disease.	sulforaphane	10-22	nucleotide binding oligomerization domain containing 2	Homo sapiens	26-30
25705128-0	2015	Effect of Sulforaphane on NOD2 via NF-kappaB: implications for Crohn"s disease.	sulforaphane	10-22	nuclear factor kappa B subunit 1	Homo sapiens	35-44
25705128-2	2015	Sulforaphane has been shown to inhibit PRR-mediated pro-inflammatory signalling by either directly targeting the receptor or their downstream signalling molecules such as the transcription factor, NF-kappaB.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	197-206
25705128-4	2015	We examined whether sulforaphane could suppress NF-kappaB via the NOD2 pathway.	sulforaphane	20-32	nuclear factor kappa B subunit 1	Homo sapiens	48-57
25705128-4	2015	We examined whether sulforaphane could suppress NF-kappaB via the NOD2 pathway.	sulforaphane	20-32	nucleotide binding oligomerization domain containing 2	Homo sapiens	66-70
25705128-7	2015	RESULTS: We found that sulforaphane was able to significantly suppress the ligand-induced NF-kappaB activity at physiologically relevant concentrations, achievable via the consumption of broccoli within the diet.	sulforaphane	23-35	nuclear factor kappa B subunit 1	Homo sapiens	90-99
25593219-0	2015	Sulforaphane alleviates muscular dystrophy in mdx mice by activation of Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	181-224
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	226-230
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	292-345
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	181-224
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	226-230
25593219-1	2015	Sulforaphane (SFN), one of the most important isothiocyanates in the human diet, is known to have chemo-preventive and antioxidant activities in different tissues via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 and NAD(P)H quinone oxidoreductase 1.	sulforaphane	14-17	heme oxygenase 1	Homo sapiens	292-345
26161119-0	2015	Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells.	sulforaphane	0-12	DNA methyltransferase 3 beta	Homo sapiens	84-90
26161119-0	2015	Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells.	sulforaphane	0-12	histone deacetylase 1	Homo sapiens	95-100
25070589-0	2015	Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells.	sulforaphane	0-12	S-phase kinase associated protein 2	Homo sapiens	28-32
25070589-0	2015	Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells.	sulforaphane	0-12	dynactin subunit 6	Homo sapiens	46-49
25070589-0	2015	Sulforaphane down-regulates SKP2 to stabilize p27(KIP1) for inducing antiproliferation in human colon adenocarcinoma cells.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1B	Homo sapiens	50-54
25070589-4	2015	We herein provide the first evidence supporting the critical involvement of the SKP2-p27(KIP1) axis in sulforaphane-induced antiproliferation in various human colon adenocarcinoma cell lines.	sulforaphane	103-115	S-phase kinase associated protein 2	Homo sapiens	80-84
25070589-4	2015	We herein provide the first evidence supporting the critical involvement of the SKP2-p27(KIP1) axis in sulforaphane-induced antiproliferation in various human colon adenocarcinoma cell lines.	sulforaphane	103-115	dynactin subunit 6	Homo sapiens	85-88
25070589-4	2015	We herein provide the first evidence supporting the critical involvement of the SKP2-p27(KIP1) axis in sulforaphane-induced antiproliferation in various human colon adenocarcinoma cell lines.	sulforaphane	103-115	cyclin dependent kinase inhibitor 1B	Homo sapiens	89-93
25070589-6	2015	Of note, sulforaphane-induced antiproliferation was accompanied with down-regulation of SKP2, leading to the stabilization and thus up-regulation of p27(KIP1).	sulforaphane	9-21	S-phase kinase associated protein 2	Homo sapiens	88-92
25070589-6	2015	Of note, sulforaphane-induced antiproliferation was accompanied with down-regulation of SKP2, leading to the stabilization and thus up-regulation of p27(KIP1).	sulforaphane	9-21	dynactin subunit 6	Homo sapiens	149-152
25070589-6	2015	Of note, sulforaphane-induced antiproliferation was accompanied with down-regulation of SKP2, leading to the stabilization and thus up-regulation of p27(KIP1).	sulforaphane	9-21	cyclin dependent kinase inhibitor 1B	Homo sapiens	153-157
25070589-7	2015	Additionally, sulforaphane was found to down-regulate SKP2 mainly through transcriptional repression, as sulforaphane lowered SKP2 mRNA expression and the SKP2 promoter activity.	sulforaphane	14-26	S-phase kinase associated protein 2	Homo sapiens	54-58
25070589-7	2015	Additionally, sulforaphane was found to down-regulate SKP2 mainly through transcriptional repression, as sulforaphane lowered SKP2 mRNA expression and the SKP2 promoter activity.	sulforaphane	14-26	S-phase kinase associated protein 2	Homo sapiens	126-130
25070589-7	2015	Additionally, sulforaphane was found to down-regulate SKP2 mainly through transcriptional repression, as sulforaphane lowered SKP2 mRNA expression and the SKP2 promoter activity.	sulforaphane	14-26	S-phase kinase associated protein 2	Homo sapiens	126-130
25070589-7	2015	Additionally, sulforaphane was found to down-regulate SKP2 mainly through transcriptional repression, as sulforaphane lowered SKP2 mRNA expression and the SKP2 promoter activity.	sulforaphane	105-117	S-phase kinase associated protein 2	Homo sapiens	54-58
25070589-7	2015	Additionally, sulforaphane was found to down-regulate SKP2 mainly through transcriptional repression, as sulforaphane lowered SKP2 mRNA expression and the SKP2 promoter activity.	sulforaphane	105-117	S-phase kinase associated protein 2	Homo sapiens	126-130
25070589-7	2015	Additionally, sulforaphane was found to down-regulate SKP2 mainly through transcriptional repression, as sulforaphane lowered SKP2 mRNA expression and the SKP2 promoter activity.	sulforaphane	105-117	S-phase kinase associated protein 2	Homo sapiens	126-130
25070589-8	2015	Furthermore, sulforaphane treatment led to the activation of both AKT and ERK, thus ruling out the possibility that sulforaphane down-regulates SKP2 by inhibiting AKT or ERK.	sulforaphane	13-25	AKT serine/threonine kinase 1	Homo sapiens	66-69
25070589-8	2015	Furthermore, sulforaphane treatment led to the activation of both AKT and ERK, thus ruling out the possibility that sulforaphane down-regulates SKP2 by inhibiting AKT or ERK.	sulforaphane	13-25	mitogen-activated protein kinase 1	Homo sapiens	74-77
26064977-6	2015	On the other hand, pharmacological activation of the UPS by sulforaphane ameliorated ER stress, upregulated prosurvival Bcl-2 proteins, and protected beta-cells from FFA-induced cell death.	sulforaphane	60-72	BCL2 apoptosis regulator	Homo sapiens	120-125
25053041-5	2015	Minced broccoli seedlings reduced NF-kappaB activity by 16%, while sulphoraphane, the dominant bioactive in broccoli seedlings, inhibited NF-kappaB activity with an IC50 of 5.11 mumol/l.	sulforaphane	67-80	nuclear factor kappa B subunit 1	Homo sapiens	138-147
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	S-phase kinase associated protein 2	Homo sapiens	128-132
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	dynactin subunit 6	Homo sapiens	151-154
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	cyclin dependent kinase inhibitor 1B	Homo sapiens	155-159
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	S-phase kinase associated protein 2	Homo sapiens	217-221
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	dynactin subunit 6	Homo sapiens	271-274
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	9-21	cyclin dependent kinase inhibitor 1B	Homo sapiens	275-279
25070589-9	2015	Notably, sulforaphane-elicited suppression of BrdU incorporation and clonogenicity were significantly rescued in the context of SKP2 overexpression or p27(KIP1) depletion, therefore highlighting the important role of SKP2 down-regulation and the ensuing stabilization of p27(KIP1) in sulforaphane-induced antiproliferation.	sulforaphane	284-296	S-phase kinase associated protein 2	Homo sapiens	128-132
25070589-10	2015	Collectively, these data expand our molecular understanding about how sulforaphane elicits proliferation arrest, but also implicate the application of sulforaphane in therapeutic modalities targeting SKP2.	sulforaphane	151-163	S-phase kinase associated protein 2	Homo sapiens	200-204
25568452-2	2015	Dietary compounds such as sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms such as DNA methyltransferase (DNMT) inhibition, histone modifications via histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or noncoding RNA expression.	sulforaphane	26-38	DNA methyltransferase 1	Homo sapiens	196-217
25568452-2	2015	Dietary compounds such as sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms such as DNA methyltransferase (DNMT) inhibition, histone modifications via histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or noncoding RNA expression.	sulforaphane	26-38	DNA methyltransferase 1	Homo sapiens	219-223
25568452-2	2015	Dietary compounds such as sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms such as DNA methyltransferase (DNMT) inhibition, histone modifications via histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or noncoding RNA expression.	sulforaphane	40-43	DNA methyltransferase 1	Homo sapiens	196-217
25568452-2	2015	Dietary compounds such as sulforaphane (SFN) found in cruciferous vegetables and epigallocatechin-3-gallate (EGCG) in green tea exhibit the ability to affect various epigenetic mechanisms such as DNA methyltransferase (DNMT) inhibition, histone modifications via histone deacetylase (HDAC), histone acetyltransferase (HAT) inhibition, or noncoding RNA expression.	sulforaphane	40-43	DNA methyltransferase 1	Homo sapiens	219-223
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	53-65	phosphatase and tensin homolog	Homo sapiens	155-159
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	53-65	DNA methyltransferase 1	Homo sapiens	269-274
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	53-65	tumor protein p53	Homo sapiens	277-280
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	53-65	H3 histone pseudogene 16	Homo sapiens	287-290
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	67-70	phosphatase and tensin homolog	Homo sapiens	155-159
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	67-70	DNA methyltransferase 1	Homo sapiens	269-274
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	67-70	tumor protein p53	Homo sapiens	277-280
26372775-2	2015	In the present study, we investigated the effects of sulforaphane (SFN), a phytochemical from cruciferous vegetables, on the methylation and expression of PTEN and RARbeta2 tumour suppressor genes as well as on the expression of regulators of DNA methylation reaction, DNMT1 , p53 , and p21 , in MCF-7 and MDA-MB-231 human breast cancer cells with different invasive potential.	sulforaphane	67-70	H3 histone pseudogene 16	Homo sapiens	287-290
26583056-0	2015	Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
26583056-7	2015	SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	14-36
26583056-8	2015	This review will summarize the evidence from clinical studies and animal experiments relating to the potential mechanisms by which SFN modulates Nrf2 activation and protects against CVD.	sulforaphane	131-134	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
25169428-0	2014	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression.	sulforaphane	0-12	plasminogen activator, tissue type	Homo sapiens	27-30
25536319-0	2015	Activation of Nrf2 by ischemic preconditioning and sulforaphane in renal ischemia/reperfusion injury: a comparative experimental study.	sulforaphane	51-63	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
25486523-0	2014	SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.	sulforaphane	27-39	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
25486523-0	2014	SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.	sulforaphane	27-39	proprotein convertase subtilisin/kexin type 1	Homo sapiens	71-74
25486523-4	2014	In this investigation we demonstrate that sulforaphane induces posttranslational modification of histone methyltransferase SUV39H1 in metastatic, androgen receptor-negative PC3 prostate cancer cells.	sulforaphane	42-54	SUV39H1 histone lysine methyltransferase	Homo sapiens	123-130
25486523-4	2014	In this investigation we demonstrate that sulforaphane induces posttranslational modification of histone methyltransferase SUV39H1 in metastatic, androgen receptor-negative PC3 prostate cancer cells.	sulforaphane	42-54	proprotein convertase subtilisin/kexin type 1	Homo sapiens	173-176
25486523-5	2014	Sulforaphane stimulates ubiquitination and acetylation of SUV39H1 within a C-terminal nuclear localization signal peptide motif and coincides with its dissociation from chromatin and a decrease in global trimethyl-histone H3 lysine 9 (H3K9me3) levels.	sulforaphane	0-12	SUV39H1 histone lysine methyltransferase	Homo sapiens	58-65
25486523-6	2014	Exogenous SUV39H1 expression leads to an increase in H3K9me3 and decreases sulforaphane-induced apoptotic signaling.	sulforaphane	75-87	SUV39H1 histone lysine methyltransferase	Homo sapiens	10-17
25486523-7	2014	SUV39H1 is thus identified as a novel mediator of sulforaphane cytotoxicity in PC3 cells.	sulforaphane	50-62	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-7
25486523-7	2014	SUV39H1 is thus identified as a novel mediator of sulforaphane cytotoxicity in PC3 cells.	sulforaphane	50-62	proprotein convertase subtilisin/kexin type 1	Homo sapiens	79-82
25574463-7	2014	RESULTS: Stimulation of the RAW 264.7 cells with LPS caused an elevated production of nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1beta, which was markedly inhibited by the pretreatment with SF without causing any cytotoxic effects.	sulforaphane	227-229	interleukin 1 beta	Mus musculus	149-171
25268649-0	2014	Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway.	sulforaphane	0-12	serine/threonine kinase 11	Mus musculus	141-145
25364403-0	2014	Effects of co-treatment with sulforaphane and autophagy modulators on uridine 5"-diphospho-glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco-2 human colon cancer cells.	sulforaphane	29-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-150
25364403-2	2014	Uridine 5"-diphospho (UDP)-glucuronosyltransferase (UGT)1A induction is one of the mechanisms that is responsible for the cancer chemopreventive activity of SFN.	sulforaphane	157-160	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	52-58
25192721-3	2014	Keeping this fact in mind, the recent work is designed to reveal the role of CAV1 in inhibiting cancer cell progression in presence of epigenetic modulators like 5-aza-2"-deoxycytidine (AZA), trichostatin A (TSA), S-adenosyl methionine (SAM) and sulforaphane (SFN).	sulforaphane	246-258	caveolin 1	Homo sapiens	77-81
25192721-3	2014	Keeping this fact in mind, the recent work is designed to reveal the role of CAV1 in inhibiting cancer cell progression in presence of epigenetic modulators like 5-aza-2"-deoxycytidine (AZA), trichostatin A (TSA), S-adenosyl methionine (SAM) and sulforaphane (SFN).	sulforaphane	260-263	caveolin 1	Homo sapiens	77-81
24512358-7	2014	The Nrf2 activator sulforaphane enhanced the Nrf2 response both in vitro and in vivo, thereby preventing aldosterone-induced DNA damage.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
24512358-7	2014	The Nrf2 activator sulforaphane enhanced the Nrf2 response both in vitro and in vivo, thereby preventing aldosterone-induced DNA damage.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	nuclear factor kappa B subunit 1	Homo sapiens	172-194
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	nuclear factor kappa B subunit 1	Homo sapiens	196-205
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	315-319
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	315-319
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	homeobox D13	Homo sapiens	403-406
24817443-0	2014	Antithrombotic activities of sulforaphane via inhibiting platelet aggregation and FIIa/FXa.	sulforaphane	29-41	coagulation factor X	Homo sapiens	87-90
24817443-7	2014	In addition, treatment with SFN resulted in significant reduction of the PAI-1 to t-PA ratio.	sulforaphane	28-31	serpin family E member 1	Homo sapiens	73-78
24817443-7	2014	In addition, treatment with SFN resulted in significant reduction of the PAI-1 to t-PA ratio.	sulforaphane	28-31	plasminogen activator, tissue type	Homo sapiens	82-86
24895206-0	2014	Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells.	sulforaphane	0-12	programmed cell death 4	Mus musculus	69-74
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	sulforaphane	141-153	programmed cell death 4	Mus musculus	42-47
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	sulforaphane	141-153	thymoma viral proto-oncogene 1	Mus musculus	192-196
24895206-4	2014	We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells.	sulforaphane	141-153	programmed cell death 4	Mus musculus	257-262
24895206-5	2014	We propose that sulforaphane suppression of PDCD4 downregulation serves as a novel molecular mechanism to control proliferation in response to pro-inflammatory signals.	sulforaphane	16-28	programmed cell death 4	Mus musculus	44-49
25178721-11	2014	The in-source fragmentation experiments revealed that SFN is binding to free NH(2) groups (N-terminal amino acid and lysines) in Abeta.	sulforaphane	54-57	amyloid beta precursor protein	Homo sapiens	129-134
25178721-13	2014	CONCLUSIONS: The interaction of SFN, an anticancer agent, with Abeta was studied using ESI-MS. SFN is found to bind covalently and specifically with the free NH(2) group of N-terminal aspartic acid and the epsilon-amino group of lysine at positions 16 and 28.	sulforaphane	32-35	amyloid beta precursor protein	Homo sapiens	63-68
25178721-13	2014	CONCLUSIONS: The interaction of SFN, an anticancer agent, with Abeta was studied using ESI-MS. SFN is found to bind covalently and specifically with the free NH(2) group of N-terminal aspartic acid and the epsilon-amino group of lysine at positions 16 and 28.	sulforaphane	95-98	amyloid beta precursor protein	Homo sapiens	63-68
25178721-14	2014	Aggregation assay studies showed a lesser inclination of Abeta to aggregate when SFN is present.	sulforaphane	81-84	amyloid beta precursor protein	Homo sapiens	57-62
25234182-5	2015	There were found some remarkable differences in the effect of SFN at a dose of 5 micromol/L on CYP19 expression: in ER(+) MCF7 significant reduction, in ER(-) MDA-MB-231 an increased expression and unchanged expression in MCF10A cell line.	sulforaphane	62-65	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	95-100
25470382-0	2014	Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	103-107
25470382-0	2014	Sulforaphane protects rodent retinas against ischemia-reperfusion injury through the activation of the Nrf2/HO-1 antioxidant pathway.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	108-112
25284333-3	2014	METHODS AND RESULTS: We find that exposure of the LPS receptor Toll-like receptor-4 (TLR4) to physiologically appropriate concentrations of SF under non-reducing conditions results in covalent modification of cysteine residues 246 and 609.	sulforaphane	140-142	toll like receptor 4	Homo sapiens	85-89
25192721-4	2014	Forced expression of CAV1 by AZA, TSA, and SFN is correlated to induction of apoptosis and inhibition of cell migration in breast cancer.	sulforaphane	43-46	caveolin 1	Homo sapiens	21-25
25299679-0	2014	Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
25305463-7	2014	Pretreatment with tert-butyl hydroquinone (tBHQ) or sulforaphane, known Nrf2 inducers, reduced BDE-47-stimulated IL-6 release with increased ARE reporter activity, reduced nuclear factor kappa B (NF-kappaB) reporter activity, increased GSH production, and stimulated expression of antioxidant genes compared to non-Nrf2 inducer pretreated groups, suggesting that Nrf2 may play a protective role against BDE-47-mediated inflammatory responses in HTR-8/SVneo cells.	sulforaphane	52-64	homeobox D13	Homo sapiens	95-98
25172557-5	2014	Utilizing antioxidant response element (ARE)-containing luciferase reporter constructs as read-outs for Nrf2 activity, our data indicated that E2 increased ARE activity >14-fold and enhanced the action of the Nrf2 activators, tertiary butylhydroquinone (tBHQ) and sulforaphane (Sul) 4 to 9 fold compared with cells treated with tBHQ or Sul as single agents.	sulforaphane	267-279	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
25172557-5	2014	Utilizing antioxidant response element (ARE)-containing luciferase reporter constructs as read-outs for Nrf2 activity, our data indicated that E2 increased ARE activity >14-fold and enhanced the action of the Nrf2 activators, tertiary butylhydroquinone (tBHQ) and sulforaphane (Sul) 4 to 9 fold compared with cells treated with tBHQ or Sul as single agents.	sulforaphane	267-279	NFE2 like bZIP transcription factor 2	Homo sapiens	212-216
25169428-0	2014	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression.	sulforaphane	0-12	programmed cell death 4	Homo sapiens	40-45
25169428-0	2014	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression.	sulforaphane	0-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-96
25169428-0	2014	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression.	sulforaphane	0-12	H3 histone pseudogene 16	Homo sapiens	114-117
25169428-0	2014	Sulforaphane inhibition of TPA-mediated PDCD4 downregulation contributes to suppression of c-Jun and induction of p21-dependent Nrf2 expression.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
25169428-3	2014	In addition, we observed that sulforaphane suppression of TPA-induced S6K1 and ERK1/2 activation played a critical role in attenuating PDCD4 poly-ubiquitination and Pdcd4 mRNA downregulation.	sulforaphane	30-42	plasminogen activator, tissue type	Homo sapiens	58-61
25169428-3	2014	In addition, we observed that sulforaphane suppression of TPA-induced S6K1 and ERK1/2 activation played a critical role in attenuating PDCD4 poly-ubiquitination and Pdcd4 mRNA downregulation.	sulforaphane	30-42	ribosomal protein S6 kinase B1	Homo sapiens	70-74
25169428-3	2014	In addition, we observed that sulforaphane suppression of TPA-induced S6K1 and ERK1/2 activation played a critical role in attenuating PDCD4 poly-ubiquitination and Pdcd4 mRNA downregulation.	sulforaphane	30-42	mitogen-activated protein kinase 3	Homo sapiens	79-85
25169428-3	2014	In addition, we observed that sulforaphane suppression of TPA-induced S6K1 and ERK1/2 activation played a critical role in attenuating PDCD4 poly-ubiquitination and Pdcd4 mRNA downregulation.	sulforaphane	30-42	programmed cell death 4	Homo sapiens	135-140
25169428-3	2014	In addition, we observed that sulforaphane suppression of TPA-induced S6K1 and ERK1/2 activation played a critical role in attenuating PDCD4 poly-ubiquitination and Pdcd4 mRNA downregulation.	sulforaphane	30-42	programmed cell death 4	Homo sapiens	165-170
25169428-6	2014	Collectively, our study illustrates that attenuating the rate of PDCD4 proteolysis and Pdcd4 mRNA degradation serves as a novel anti-inflammatory and cytoprotective mechanism of sulforaphane.	sulforaphane	178-190	programmed cell death 4	Homo sapiens	65-70
25169428-6	2014	Collectively, our study illustrates that attenuating the rate of PDCD4 proteolysis and Pdcd4 mRNA degradation serves as a novel anti-inflammatory and cytoprotective mechanism of sulforaphane.	sulforaphane	178-190	programmed cell death 4	Homo sapiens	87-92
25017900-0	2014	Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.	sulforaphane	0-12	membrane associated ring-CH-type finger 8	Homo sapiens	108-111
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	126-142
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	144-148
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	0-12	peroxiredoxin 1	Homo sapiens	154-169
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	0-12	peroxiredoxin 1	Homo sapiens	171-176
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	14-17	heme oxygenase 1	Homo sapiens	126-142
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	14-17	heme oxygenase 1	Homo sapiens	144-148
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	14-17	peroxiredoxin 1	Homo sapiens	154-169
26461289-4	2014	Sulforaphane (SFN) is an isothiocyanate present in cruciferous vegetables that can induce antioxidant defence enzymes such as heme oxygenase-1 (HO-1) and peroxiredoxin-1 (Prx-1).	sulforaphane	14-17	peroxiredoxin 1	Homo sapiens	171-176
26461289-8	2014	Interestingly preliminary data suggest that treatment of SMC with SFN for 12 or 24h enhances the expression of klotho.	sulforaphane	66-69	klotho	Homo sapiens	111-117
24993616-0	2014	Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
24993616-4	2014	Sulforaphane-induced apoptosis was associated with mitochondria dysfunction, cytochrome c release and Bcl-2/Bax dysregulation.	sulforaphane	0-12	cytochrome c, somatic	Homo sapiens	77-89
24993616-4	2014	Sulforaphane-induced apoptosis was associated with mitochondria dysfunction, cytochrome c release and Bcl-2/Bax dysregulation.	sulforaphane	0-12	BCL2 apoptosis regulator	Homo sapiens	102-107
24993616-4	2014	Sulforaphane-induced apoptosis was associated with mitochondria dysfunction, cytochrome c release and Bcl-2/Bax dysregulation.	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	108-111
24671668-0	2014	Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	22-30
24671668-0	2014	Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2.	sulforaphane	0-12	matrix metallopeptidase 1	Homo sapiens	120-124
24671668-0	2014	Sulforaphane inhibits IL-1beta-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production of MMPs, COX-2, and PGE2.	sulforaphane	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	sulforaphane	50-62	interleukin 1 beta	Homo sapiens	66-83
24671668-1	2014	This study was performed to define the effects of sulforaphane on interleukin-1beta (IL-1beta)-induced proliferation of rheumatoid arthritis synovial fibroblasts (RASFs), the expression of matrix metalloproteinases (MMPs) and cyclooxygenase (COX), and the production of prostaglandin E2 (PGE2) by RASFs.	sulforaphane	50-62	interleukin 1 beta	Homo sapiens	85-93
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	39-47
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	matrix metallopeptidase 1	Homo sapiens	98-103
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	matrix metallopeptidase 3	Homo sapiens	105-110
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-121
24671668-4	2014	Sulforaphane inhibits unstimulated and IL-1beta-induced proliferation of RASFs; the expression of MMP-1, MMP-3, and COX-2 mRNA and protein; and the PGE2 production induced by IL-1beta.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	175-183
24671668-5	2014	Sulforaphane also inhibits the phosphorylation of ERK-1/2, p-38, and JNK and activation of NF-kB by IL-1beta.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	50-57
24671668-5	2014	Sulforaphane also inhibits the phosphorylation of ERK-1/2, p-38, and JNK and activation of NF-kB by IL-1beta.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	59-63
24671668-5	2014	Sulforaphane also inhibits the phosphorylation of ERK-1/2, p-38, and JNK and activation of NF-kB by IL-1beta.	sulforaphane	0-12	mitogen-activated protein kinase 8	Homo sapiens	69-72
24671668-5	2014	Sulforaphane also inhibits the phosphorylation of ERK-1/2, p-38, and JNK and activation of NF-kB by IL-1beta.	sulforaphane	0-12	interleukin 1 beta	Homo sapiens	100-108
24671668-6	2014	These results indicate that sulforaphane inhibits the proliferation of synovial fibroblasts, the expression of MMPs and COX-2, and the production of PGE2, which are involved in synovitis and destruction of RA, and suggest that sulforaphane might be a new therapeutic agent for RA.	sulforaphane	28-40	matrix metallopeptidase 1	Homo sapiens	111-115
24671668-6	2014	These results indicate that sulforaphane inhibits the proliferation of synovial fibroblasts, the expression of MMPs and COX-2, and the production of PGE2, which are involved in synovitis and destruction of RA, and suggest that sulforaphane might be a new therapeutic agent for RA.	sulforaphane	28-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
24993616-7	2014	Furthermore, sulforaphane was observed to activate endoplasmic reticulum (ER) stress and the nuclear factor-E2-related factor-2 (Nrf2) signaling pathway, as demonstrated by the upregulation of ER stress-related proteins, including glucose-regulated protein 78 and C/EBP-homologous protein, and the accumulation of phosphorylated Nrf2 proteins in the nucleus and induction of heme oxygenase-1 expression, respectively.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
24993616-7	2014	Furthermore, sulforaphane was observed to activate endoplasmic reticulum (ER) stress and the nuclear factor-E2-related factor-2 (Nrf2) signaling pathway, as demonstrated by the upregulation of ER stress-related proteins, including glucose-regulated protein 78 and C/EBP-homologous protein, and the accumulation of phosphorylated Nrf2 proteins in the nucleus and induction of heme oxygenase-1 expression, respectively.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	329-333
24993616-7	2014	Furthermore, sulforaphane was observed to activate endoplasmic reticulum (ER) stress and the nuclear factor-E2-related factor-2 (Nrf2) signaling pathway, as demonstrated by the upregulation of ER stress-related proteins, including glucose-regulated protein 78 and C/EBP-homologous protein, and the accumulation of phosphorylated Nrf2 proteins in the nucleus and induction of heme oxygenase-1 expression, respectively.	sulforaphane	13-25	heme oxygenase 1	Homo sapiens	375-391
24993616-8	2014	Taken together, these results demonstrate that sulforaphane has antitumor effects against bladder cancer cells through an ROS-mediated intrinsic apoptotic pathway, and suggest that ER stress and Nrf2 may represent strategic targets for sulforaphane-induced apoptosis.	sulforaphane	236-248	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
25017900-0	2014	Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.	sulforaphane	0-12	KRAS proto-oncogene, GTPase	Homo sapiens	132-137
25017900-8	2014	These data demonstrate that sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.	sulforaphane	28-40	membrane associated ring-CH-type finger 8	Homo sapiens	131-134
25017900-8	2014	These data demonstrate that sulforaphane, quercetin and GTC complement each other in inhibition of PDA progression by induction of miR-let7-a and inhibition of K-ras.	sulforaphane	28-40	KRAS proto-oncogene, GTPase	Homo sapiens	160-165
25238321-3	2014	In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-alpha-induced ECV 304 endothelial cells.	sulforaphane	39-51	tumor necrosis factor	Homo sapiens	131-140
25238321-0	2014	Sulforaphane inhibits TNF-alpha-induced adhesion molecule expression through the Rho A/ROCK/NF-kappaB signaling pathway.	sulforaphane	0-12	tumor necrosis factor	Homo sapiens	22-31
25238321-0	2014	Sulforaphane inhibits TNF-alpha-induced adhesion molecule expression through the Rho A/ROCK/NF-kappaB signaling pathway.	sulforaphane	0-12	ras homolog family member A	Homo sapiens	81-86
25238321-3	2014	In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-alpha-induced ECV 304 endothelial cells.	sulforaphane	53-56	intercellular adhesion molecule 1	Homo sapiens	85-118
25238321-0	2014	Sulforaphane inhibits TNF-alpha-induced adhesion molecule expression through the Rho A/ROCK/NF-kappaB signaling pathway.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	92-101
25238321-3	2014	In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-alpha-induced ECV 304 endothelial cells.	sulforaphane	39-51	intercellular adhesion molecule 1	Homo sapiens	85-118
25238321-3	2014	In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-alpha-induced ECV 304 endothelial cells.	sulforaphane	53-56	intercellular adhesion molecule 1	Homo sapiens	120-126
25238321-3	2014	In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-alpha-induced ECV 304 endothelial cells.	sulforaphane	39-51	intercellular adhesion molecule 1	Homo sapiens	120-126
25238321-3	2014	In this study, we investigated whether sulforaphane (SFN) affected the expression of intracellular adhesion molecule-1 (ICAM-1) in TNF-alpha-induced ECV 304 endothelial cells.	sulforaphane	53-56	tumor necrosis factor	Homo sapiens	131-140
25238321-8	2014	Collectively, SFN inhibited the NF-kappaB DNA binding activity and downregulated the TNF-alpha-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-kappaB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.	sulforaphane	14-17	nuclear factor kappa B subunit 1	Homo sapiens	32-41
25238321-8	2014	Collectively, SFN inhibited the NF-kappaB DNA binding activity and downregulated the TNF-alpha-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-kappaB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.	sulforaphane	14-17	tumor necrosis factor	Homo sapiens	85-94
25238321-8	2014	Collectively, SFN inhibited the NF-kappaB DNA binding activity and downregulated the TNF-alpha-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-kappaB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.	sulforaphane	14-17	intercellular adhesion molecule 1	Homo sapiens	117-123
25238321-8	2014	Collectively, SFN inhibited the NF-kappaB DNA binding activity and downregulated the TNF-alpha-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-kappaB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.	sulforaphane	14-17	ras homolog family member A	Homo sapiens	163-168
25238321-8	2014	Collectively, SFN inhibited the NF-kappaB DNA binding activity and downregulated the TNF-alpha-mediated induction of ICAM-1 in endothelial cells by inhibiting the Rho A/ROCK/NF-kappaB signaling pathway, suggesting the beneficial effects of SFN on suppression of inflammation within the atherosclerotic lesion.	sulforaphane	14-17	nuclear factor kappa B subunit 1	Homo sapiens	174-183
25053821-8	2014	Moreover, CBP501 sensitivity is modulated by silencing or sulforaphane-induced overexpression of Nrf2.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
25106942-7	2014	Therapeutic effect of Nrf2 inducer sulforaphane (SFN) was evaluated.	sulforaphane	35-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
25106942-7	2014	Therapeutic effect of Nrf2 inducer sulforaphane (SFN) was evaluated.	sulforaphane	49-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
25106942-12	2014	Upregulation of Nrf2 by SFN not only restored the intracellular oxidative toxicity but also cell proliferation and testosterone secretion in response to DBP.	sulforaphane	24-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
24867960-6	2014	The proteasomal turnover of the AR is abetted by diets with a high ratio of long-chain omega-3 to omega-6 fatty acids, which are beneficial in prostate cancer xenograft models; berberine and sulforaphane, by inhibiting AR"s interaction with its chaperone Hsp90, likewise promote AR proteasomal degradation and retard growth of human prostate cancer in nude mice.	sulforaphane	191-203	androgen receptor	Homo sapiens	32-34
25241332-4	2014	Advanced glycation end product stimulated superoxide generation as well as RAGE gene and protein expression in bovine-cultured retinal pericytes, and these effects were prevented by the treatment with sulforaphane.	sulforaphane	201-213	advanced glycosylation end-product specific receptor	Bos taurus	75-79
24998607-6	2014	Furthermore, NaHS up-regulated NRF2 protein expression, its nuclear translocation, and the transcription of the two key downstream antioxidant genes Peroxiredoxin-1 and NAD(P)H dehydrogenase quinone 1, suggesting that NRF2 activation may inhibit human osteoclast differentiation by activating a sustained antioxidant response in osteoclast progenitors; furthermore, NRF2 activators Sulforaphane and Tert-butylhydroquinone inhibited in vitro human osteoclast differentiation.	sulforaphane	382-394	NFE2 like bZIP transcription factor 2	Homo sapiens	218-222
24998607-6	2014	Furthermore, NaHS up-regulated NRF2 protein expression, its nuclear translocation, and the transcription of the two key downstream antioxidant genes Peroxiredoxin-1 and NAD(P)H dehydrogenase quinone 1, suggesting that NRF2 activation may inhibit human osteoclast differentiation by activating a sustained antioxidant response in osteoclast progenitors; furthermore, NRF2 activators Sulforaphane and Tert-butylhydroquinone inhibited in vitro human osteoclast differentiation.	sulforaphane	382-394	NFE2 like bZIP transcription factor 2	Homo sapiens	218-222
24971463-0	2014	Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice.	sulforaphane	0-12	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	64-69
24971463-6	2014	ARMS cells transfected with siDR5 showed that SFN-induced DR5 acts as a key regulator, being directly related to the TRAIL-induced cell-growth inhibition.	sulforaphane	46-49	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	30-33
24971463-6	2014	ARMS cells transfected with siDR5 showed that SFN-induced DR5 acts as a key regulator, being directly related to the TRAIL-induced cell-growth inhibition.	sulforaphane	46-49	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	117-122
25241332-6	2014	Sulforaphane and antibodies directed against RAGE significantly inhibited the AGE-induced decrease in DNA synthesis, apoptotic cell death, and up-regulation of monocyte chemoattractant protein 1 messenger RNA levels in pericytes.	sulforaphane	0-12	C-C motif chemokine 2	Bos taurus	160-194
25241332-7	2014	For the first time, the present study demonstrates that sulforaphane could inhibit DNA synthesis, apoptotic cell death, and inflammatory reactions in AGE-exposed pericytes, partly by suppressing RAGE expression via its antioxidative properties.	sulforaphane	56-68	advanced glycosylation end-product specific receptor	Bos taurus	195-199
25241332-8	2014	Blockade of the AGE-RAGE axis in pericytes by sulforaphane might be a novel therapeutic target for the treatment of diabetic retinopathy.	sulforaphane	46-58	advanced glycosylation end-product specific receptor	Bos taurus	20-24
24967692-0	2014	Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function.	sulforaphane	14-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
24967692-2	2014	The nuclear factor-erythroid 2-related factor 2 (Nrf2), as a master transcription factor in controlling anti-oxidative systems, is able to be induced by sulforaphane (SFN).	sulforaphane	153-165	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-47
24967692-2	2014	The nuclear factor-erythroid 2-related factor 2 (Nrf2), as a master transcription factor in controlling anti-oxidative systems, is able to be induced by sulforaphane (SFN).	sulforaphane	153-165	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
24967692-2	2014	The nuclear factor-erythroid 2-related factor 2 (Nrf2), as a master transcription factor in controlling anti-oxidative systems, is able to be induced by sulforaphane (SFN).	sulforaphane	167-170	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-47
24967692-2	2014	The nuclear factor-erythroid 2-related factor 2 (Nrf2), as a master transcription factor in controlling anti-oxidative systems, is able to be induced by sulforaphane (SFN).	sulforaphane	167-170	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
24967692-11	2014	SFN is able to prevent testicular oxidative damage and apoptosis in type 1 diabetes mice, which may be associated with the preservation of testicular Nrf2 expression and function under diabetic condition.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	150-154
24747121-4	2014	Treatment of MCF-10A cells with sulforaphane significantly inhibited TPA-induced expression of COX-2 protein and its mRNA transcript.	sulforaphane	32-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	95-100
24747121-6	2014	Pretreatment with sulforaphane significantly attenuated nuclear localization, DNA binding and the transcriptional activity of NF-kappaB through inhibition of phosphorylation and subsequent degradation of IkappaBalpha in MCF-10A cells stimulated with TPA.	sulforaphane	18-30	nuclear factor kappa B subunit 1	Homo sapiens	126-135
24747121-0	2014	Sulforaphane inhibits phorbol ester-stimulated IKK-NF-kappaB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-kappaB activating kinase and ERK.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	51-60
24747121-6	2014	Pretreatment with sulforaphane significantly attenuated nuclear localization, DNA binding and the transcriptional activity of NF-kappaB through inhibition of phosphorylation and subsequent degradation of IkappaBalpha in MCF-10A cells stimulated with TPA.	sulforaphane	18-30	NFKB inhibitor alpha	Homo sapiens	204-216
24747121-0	2014	Sulforaphane inhibits phorbol ester-stimulated IKK-NF-kappaB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-kappaB activating kinase and ERK.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	sulforaphane	0-12	TANK binding kinase 1	Homo sapiens	78-105
24747121-0	2014	Sulforaphane inhibits phorbol ester-stimulated IKK-NF-kappaB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-kappaB activating kinase and ERK.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	139-148
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	sulforaphane	0-12	TANK binding kinase 1	Homo sapiens	107-110
24747121-0	2014	Sulforaphane inhibits phorbol ester-stimulated IKK-NF-kappaB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-kappaB activating kinase and ERK.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	171-174
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	sulforaphane	154-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	33-49
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	116-157
24952354-0	2014	Sulforaphane induces autophagy through ERK activation in neuronal cells.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	39-42
24747121-7	2014	Sulforaphane also attenuated TPA-induced activation of IkappaB kinases (IKK), NF-kappaB-activating kinase (NAK) and extracellular signal-regulated kinase-1/2 (ERK1/2).	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	159-165
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	sulforaphane	16-28	nuclear factor kappa B subunit 1	Homo sapiens	50-59
24952354-1	2014	Sulforaphane (SFN), an activator of nuclear factor E2-related factor 2 (Nrf2), has been reported to induce autophagy in several cells.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	sulforaphane	16-28	prostaglandin-endoperoxide synthase 2	Homo sapiens	75-80
24952354-1	2014	Sulforaphane (SFN), an activator of nuclear factor E2-related factor 2 (Nrf2), has been reported to induce autophagy in several cells.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	sulforaphane	16-28	mitogen-activated protein kinase 3	Homo sapiens	165-171
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	sulforaphane	154-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	51-56
24747121-3	2014	Since the aberrant expression of cyclooxygenase-2 (COX-2) links inflammation and cancer, the present study was aimed to elucidate the mechanisms by which sulforaphane modulates COX-2 overexpression in human mammary epithelial (MCF-10A) cells stimulated with a prototypic tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	sulforaphane	154-166	prostaglandin-endoperoxide synthase 2	Homo sapiens	177-182
24952354-3	2014	Here, we provide evidence that SFN induces autophagy with increased levels of LC3-II through extracellular signal-regulated kinase (ERK) activation in neuronal cells.	sulforaphane	31-34	mitogen-activated protein kinase 1	Homo sapiens	93-130
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	sulforaphane	16-28	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	172-180
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	sulforaphane	16-28	TANK binding kinase 1	Homo sapiens	185-188
24952354-3	2014	Here, we provide evidence that SFN induces autophagy with increased levels of LC3-II through extracellular signal-regulated kinase (ERK) activation in neuronal cells.	sulforaphane	31-34	mitogen-activated protein kinase 1	Homo sapiens	132-135
24747121-10	2014	Taken together, sulforaphane inhibits TPA-induced NF-kappaB activation and COX-2 expression in MCF-10A cells by blocking two distinct signaling pathways mediated by ERK1/2-IKKalpha and NAK-IKKbeta.	sulforaphane	16-28	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	189-196
24952354-4	2014	Pretreatment with NAC (N-acetyl-l-cysteine), a well-known antioxidant, completely blocked the SFN-induced increase in LC3-II levels and activation of ERK.	sulforaphane	94-97	X-linked Kx blood group	Homo sapiens	18-21
24952354-4	2014	Pretreatment with NAC (N-acetyl-l-cysteine), a well-known antioxidant, completely blocked the SFN-induced increase in LC3-II levels and activation of ERK.	sulforaphane	94-97	mitogen-activated protein kinase 1	Homo sapiens	150-153
24943846-4	2014	We also demonstrate that sulforaphane (SFN), an antioxidant, regulates Nrf2 activity by controlling abundance and subcellular distribution of PML and that PML is essential for SFN-mediated ROS increase, Nrf2 activation, antiproliferation, antimigration, and antiangiogenesis.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
24952354-6	2014	Together, the results suggest that SFN-mediated generation of reactive oxygen species (ROS) induces autophagy via ERK activation, independent of Nrf2 activity in neuronal cells.	sulforaphane	35-38	mitogen-activated protein kinase 1	Homo sapiens	114-117
24952354-6	2014	Together, the results suggest that SFN-mediated generation of reactive oxygen species (ROS) induces autophagy via ERK activation, independent of Nrf2 activity in neuronal cells.	sulforaphane	35-38	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
25196440-2	2014	This study was designed to investigate the neuroprotective effects of sulforaphane (an activator of NF-E2-related factor 2) on mice with AD-like lesions induced by combined administration of aluminum and D-galactose.	sulforaphane	70-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-122
24943846-4	2014	We also demonstrate that sulforaphane (SFN), an antioxidant, regulates Nrf2 activity by controlling abundance and subcellular distribution of PML and that PML is essential for SFN-mediated ROS increase, Nrf2 activation, antiproliferation, antimigration, and antiangiogenesis.	sulforaphane	25-37	PML nuclear body scaffold	Homo sapiens	142-145
24943846-4	2014	We also demonstrate that sulforaphane (SFN), an antioxidant, regulates Nrf2 activity by controlling abundance and subcellular distribution of PML and that PML is essential for SFN-mediated ROS increase, Nrf2 activation, antiproliferation, antimigration, and antiangiogenesis.	sulforaphane	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
24943846-4	2014	We also demonstrate that sulforaphane (SFN), an antioxidant, regulates Nrf2 activity by controlling abundance and subcellular distribution of PML and that PML is essential for SFN-mediated ROS increase, Nrf2 activation, antiproliferation, antimigration, and antiangiogenesis.	sulforaphane	39-42	PML nuclear body scaffold	Homo sapiens	142-145
24943846-4	2014	We also demonstrate that sulforaphane (SFN), an antioxidant, regulates Nrf2 activity by controlling abundance and subcellular distribution of PML and that PML is essential for SFN-mediated ROS increase, Nrf2 activation, antiproliferation, antimigration, and antiangiogenesis.	sulforaphane	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
24943846-4	2014	We also demonstrate that sulforaphane (SFN), an antioxidant, regulates Nrf2 activity by controlling abundance and subcellular distribution of PML and that PML is essential for SFN-mediated ROS increase, Nrf2 activation, antiproliferation, antimigration, and antiangiogenesis.	sulforaphane	176-179	PML nuclear body scaffold	Homo sapiens	155-158
25228981-2	2014	We previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced inflammation, sunburn reaction, and is involved in sulforaphane-mediated photo-protective effects in the skin.	sulforaphane	139-151	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
25050614-6	2014	Interestingly, synergy of NQO1 induction was also seen for physiologically relevant doses of sulforaphane (SF) and quercetin, two key bioactives present in broccoli.	sulforaphane	93-105	NAD(P)H dehydrogenase, quinone 1	Mus musculus	26-30
25050614-6	2014	Interestingly, synergy of NQO1 induction was also seen for physiologically relevant doses of sulforaphane (SF) and quercetin, two key bioactives present in broccoli.	sulforaphane	107-109	NAD(P)H dehydrogenase, quinone 1	Mus musculus	26-30
24880493-0	2014	Sulforaphane reduces vascular inflammation in mice and prevents TNF-alpha-induced monocyte adhesion to primary endothelial cells through interfering with the NF-kappaB pathway.	sulforaphane	0-12	tumor necrosis factor	Mus musculus	64-73
24880493-3	2014	Here, we report that a sulforaphane concentration as low as 0.5 muM significantly inhibited tumor necrosis factor-alpha (TNF-alpha)-induced adhesion of monocytes to human umbilical vein endothelial cells, a key event in the pathogenesis of atherosclerosis both in static and under flow conditions.	sulforaphane	23-35	tumor necrosis factor	Homo sapiens	92-119
24880493-3	2014	Here, we report that a sulforaphane concentration as low as 0.5 muM significantly inhibited tumor necrosis factor-alpha (TNF-alpha)-induced adhesion of monocytes to human umbilical vein endothelial cells, a key event in the pathogenesis of atherosclerosis both in static and under flow conditions.	sulforaphane	23-35	tumor necrosis factor	Homo sapiens	121-130
24880493-4	2014	Such physiological concentrations of sulforaphane also significantly suppressed TNF-alpha-induced production of monocyte chemotactic protein-1 and adhesion molecules including soluble vascular adhesion molecule-1 and soluble E-selectin, key mediators in the regulation of enhanced endothelial cell-monocyte interaction.	sulforaphane	37-49	tumor necrosis factor	Mus musculus	80-89
24880493-4	2014	Such physiological concentrations of sulforaphane also significantly suppressed TNF-alpha-induced production of monocyte chemotactic protein-1 and adhesion molecules including soluble vascular adhesion molecule-1 and soluble E-selectin, key mediators in the regulation of enhanced endothelial cell-monocyte interaction.	sulforaphane	37-49	chemokine (C-C motif) ligand 2	Mus musculus	112-142
24880493-4	2014	Such physiological concentrations of sulforaphane also significantly suppressed TNF-alpha-induced production of monocyte chemotactic protein-1 and adhesion molecules including soluble vascular adhesion molecule-1 and soluble E-selectin, key mediators in the regulation of enhanced endothelial cell-monocyte interaction.	sulforaphane	37-49	selectin, endothelial cell	Mus musculus	225-235
24880493-5	2014	Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling.	sulforaphane	13-25	tumor necrosis factor	Mus musculus	36-45
24880493-5	2014	Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling.	sulforaphane	13-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-80
24880493-5	2014	Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling.	sulforaphane	13-25	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	137-149
24880493-5	2014	Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling.	sulforaphane	13-25	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	188-191
24880493-5	2014	Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling.	sulforaphane	252-264	tumor necrosis factor	Mus musculus	36-45
24880493-5	2014	Furthermore, sulforaphane inhibited TNF-alpha-induced nuclear factor (NF)-kappaB transcriptional activity, Inhibitor of NF-kappaB alpha (IkappaBalpha) degradation and subsequent NF-kappaB p65 nuclear translocation in endothelial cells, suggesting that sulforaphane can inhibit inflammation by suppressing NF-kappaB signaling.	sulforaphane	252-264	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	54-80
24521949-9	2014	Pretreatment of animals with sulforaphane reduced p38 (90% reduction) and nuclear factor-kappaB (50% reduction) phosphorylation in leukocytes and protected kidneys from injury.	sulforaphane	29-41	mitogen-activated protein kinase 14	Homo sapiens	50-53
24880493-6	2014	In an animal study, sulforaphane (300 ppm) in a mouse diet significantly abolished TNF-alpha-increased ex vivo monocyte adhesion and circulating adhesion molecules and chemokines in C57BL/6 mice.	sulforaphane	20-32	tumor necrosis factor	Mus musculus	83-92
24880493-7	2014	Histology showed that sulforaphane treatment significantly prevented the eruption of endothelial lining in the intima layer of the aorta and preserved elastin fibers" delicate organization, as shown by Verhoeff-van Gieson staining.	sulforaphane	22-34	elastin	Mus musculus	151-158
24880493-8	2014	Immunohistochemistry studies showed that sulforaphane treatment also reduced vascular adhesion molecule-1 and monocyte-derived F4/80-positive macrophages in the aorta of TNF-alpha-treated mice.	sulforaphane	41-53	tumor necrosis factor	Mus musculus	170-179
24880493-9	2014	In conclusion, sulforaphane at physiological concentrations protects against TNF-alpha-induced vascular endothelial inflammation, in both in vitro and in vivo models.	sulforaphane	15-27	tumor necrosis factor	Mus musculus	77-86
25019218-6	2014	As to its cytotoxic mechanism, we found that sulforaphane creates an oxidative cellular environment that induces DNA damage and Bax and p53 gene activation, which in turn helps trigger apoptosis.	sulforaphane	45-57	BCL2 associated X, apoptosis regulator	Homo sapiens	128-131
24970331-0	2014	Sulforaphane attenuates homocysteine-induced endoplasmic reticulum stress through Nrf-2-driven enzymes in immortalized human hepatocytes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	82-87
24970331-2	2014	After human hepatocyte line HHL-5 was preincubated with SFN and subsequently with 10 mmol/L HCY, SFN improved the pathologic changes which are caused by HCY, including cell morphological abnormality, endoplasmic reticulum (ER) swelling, excessive generation of reactive oxygen species (ROS), the increased malondialdehyde (MDA) levels, as well as the increased activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	sulforaphane	97-100	glutamic--pyruvic transaminase	Homo sapiens	375-399
24970331-2	2014	After human hepatocyte line HHL-5 was preincubated with SFN and subsequently with 10 mmol/L HCY, SFN improved the pathologic changes which are caused by HCY, including cell morphological abnormality, endoplasmic reticulum (ER) swelling, excessive generation of reactive oxygen species (ROS), the increased malondialdehyde (MDA) levels, as well as the increased activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	sulforaphane	97-100	solute carrier family 17 member 5	Homo sapiens	410-436
24970331-2	2014	After human hepatocyte line HHL-5 was preincubated with SFN and subsequently with 10 mmol/L HCY, SFN improved the pathologic changes which are caused by HCY, including cell morphological abnormality, endoplasmic reticulum (ER) swelling, excessive generation of reactive oxygen species (ROS), the increased malondialdehyde (MDA) levels, as well as the increased activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).	sulforaphane	97-100	solute carrier family 17 member 5	Homo sapiens	438-441
24970331-3	2014	Phase II enzymes, thioredoxin reductase-1 (TrxR-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), were involved in the protective effect of SFN against injury by HCY.	sulforaphane	139-142	thioredoxin reductase 1	Homo sapiens	18-41
24970331-3	2014	Phase II enzymes, thioredoxin reductase-1 (TrxR-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), were involved in the protective effect of SFN against injury by HCY.	sulforaphane	139-142	thioredoxin reductase 1	Homo sapiens	43-49
25071366-0	2014	Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
24970331-3	2014	Phase II enzymes, thioredoxin reductase-1 (TrxR-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), were involved in the protective effect of SFN against injury by HCY.	sulforaphane	139-142	NAD(P)H quinone dehydrogenase 1	Homo sapiens	55-88
24970331-3	2014	Phase II enzymes, thioredoxin reductase-1 (TrxR-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1), were involved in the protective effect of SFN against injury by HCY.	sulforaphane	139-142	NAD(P)H quinone dehydrogenase 1	Homo sapiens	90-94
24970331-5	2014	Furthermore, Nrf-2 translocation was enhanced by SFN, which lead to the induction of TrxR-1and NQO1.	sulforaphane	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	13-18
24970331-5	2014	Furthermore, Nrf-2 translocation was enhanced by SFN, which lead to the induction of TrxR-1and NQO1.	sulforaphane	49-52	thioredoxin reductase 1	Homo sapiens	85-91
24970331-5	2014	Furthermore, Nrf-2 translocation was enhanced by SFN, which lead to the induction of TrxR-1and NQO1.	sulforaphane	49-52	NAD(P)H quinone dehydrogenase 1	Homo sapiens	95-99
25019218-6	2014	As to its cytotoxic mechanism, we found that sulforaphane creates an oxidative cellular environment that induces DNA damage and Bax and p53 gene activation, which in turn helps trigger apoptosis.	sulforaphane	45-57	tumor protein p53	Homo sapiens	136-139
24988078-6	2014	Treatment with a typical Nrf2 agonist, sulforaphane (SFN), attenuated triptolide-induced liver dysfunction, structural damage, glutathione depletion and decrease in antioxidant enzymes in BALB/C mice.	sulforaphane	39-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
24814729-2	2014	In this work, we evaluated the ability of sulforaphane (SULF), a natural dietary isothiocyanate, to induce the activation of transcription factor Nrf2 (a master regulator of redox state in the cell) in a model of striatal degeneration in rats infused with quinolinic acid (QUIN).	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150
24814729-2	2014	In this work, we evaluated the ability of sulforaphane (SULF), a natural dietary isothiocyanate, to induce the activation of transcription factor Nrf2 (a master regulator of redox state in the cell) in a model of striatal degeneration in rats infused with quinolinic acid (QUIN).	sulforaphane	56-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	146-150
24988078-6	2014	Treatment with a typical Nrf2 agonist, sulforaphane (SFN), attenuated triptolide-induced liver dysfunction, structural damage, glutathione depletion and decrease in antioxidant enzymes in BALB/C mice.	sulforaphane	53-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
24988078-7	2014	Moreover, the hepatoprotective effect of SFN on triptolide-induced liver injury was associated with the activation of Nrf2 and its downstream targets.	sulforaphane	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
24786516-15	2014	CONCLUSION: miR-320a plays important role in induction of expression of HO-1, GCLM and OKL38 upon ESR induced either by OxPAPC or sulforaphane.	sulforaphane	130-142	microRNA 615	Mus musculus	12-15
24786516-9	2014	Induction of HO-1, OKL38 and GCLM mRNAs by OxPAPC and sulforaphane was attenuated upon knockdown of miR-320a.	sulforaphane	54-66	heme oxygenase 1	Mus musculus	13-17
24786516-9	2014	Induction of HO-1, OKL38 and GCLM mRNAs by OxPAPC and sulforaphane was attenuated upon knockdown of miR-320a.	sulforaphane	54-66	oxidative stress induced growth inhibitor 1	Mus musculus	19-24
24786516-15	2014	CONCLUSION: miR-320a plays important role in induction of expression of HO-1, GCLM and OKL38 upon ESR induced either by OxPAPC or sulforaphane.	sulforaphane	130-142	heme oxygenase 1	Mus musculus	72-76
24786516-9	2014	Induction of HO-1, OKL38 and GCLM mRNAs by OxPAPC and sulforaphane was attenuated upon knockdown of miR-320a.	sulforaphane	54-66	glutamate-cysteine ligase, modifier subunit	Mus musculus	29-33
24786516-15	2014	CONCLUSION: miR-320a plays important role in induction of expression of HO-1, GCLM and OKL38 upon ESR induced either by OxPAPC or sulforaphane.	sulforaphane	130-142	glutamate-cysteine ligase, modifier subunit	Mus musculus	78-82
24786516-9	2014	Induction of HO-1, OKL38 and GCLM mRNAs by OxPAPC and sulforaphane was attenuated upon knockdown of miR-320a.	sulforaphane	54-66	microRNA 615	Mus musculus	100-103
24786516-15	2014	CONCLUSION: miR-320a plays important role in induction of expression of HO-1, GCLM and OKL38 upon ESR induced either by OxPAPC or sulforaphane.	sulforaphane	130-142	oxidative stress induced growth inhibitor 1	Mus musculus	87-92
24786516-10	2014	In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs.	sulforaphane	107-119	microRNA 615	Mus musculus	38-41
24786516-10	2014	In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs.	sulforaphane	107-119	heme oxygenase 1	Mus musculus	136-140
24836869-5	2014	Sulforaphane significantly attenuated the scopolamine-induced memory impairment and improved cholinergic system reactivity, as indicated by an increased ACh level, decreased AChE activity, and increased choline acetyltransferase (ChAT) expression in the hippocampus and frontal cortex.	sulforaphane	0-12	acetylcholinesterase	Mus musculus	174-178
24786516-10	2014	In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs.	sulforaphane	107-119	oxidative stress induced growth inhibitor 1	Mus musculus	142-147
24786516-10	2014	In contrast, transfection of ECs with miR-320a mimic oligonucleotide potentiated the effects of OxPAPC and sulforaphane on induction of HO-1, OKL38 and GCLM mRNAs.	sulforaphane	107-119	glutamate-cysteine ligase, modifier subunit	Mus musculus	152-156
24801392-0	2014	Sulforaphane reduction of testicular apoptotic cell death in diabetic mice is associated with the upregulation of Nrf2 expression and function.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
24801392-2	2014	Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the antioxidative system and is inducible by sulforaphane (SFN).	sulforaphane	148-160	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-43
24801392-2	2014	Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the antioxidative system and is inducible by sulforaphane (SFN).	sulforaphane	148-160	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
24801392-2	2014	Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the antioxidative system and is inducible by sulforaphane (SFN).	sulforaphane	162-165	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-43
24801392-2	2014	Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor in controlling the antioxidative system and is inducible by sulforaphane (SFN).	sulforaphane	162-165	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
24801392-8	2014	All of these diabetic effects were significantly prevented by SFN treatment with upregulated Nrf2 expression.	sulforaphane	62-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
24836869-7	2014	Sulforaphane (10 or 20muM) increased the ACh level, decreased the AChE activity, and increased ChAT expression in scopolamine-treated primary cortical neurons.	sulforaphane	0-12	acetylcholinesterase	Mus musculus	66-70
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	188-202
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	229-234
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	237-278
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	188-202
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	229-234
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	280-284
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	237-278
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	287-292
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	280-284
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	298-330
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	287-292
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	332-336
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	298-330
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	332-336
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	39-51	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	339-344
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
24948812-2	2014	We show here that Nrf2 activation with sulforaphane (SFN) in vivo or in vitro increases expression and transport activity of three ATP-driven drug efflux pumps at the blood-brain barrier [P-glycoprotein, ATP binding cassette b1 (Abcb1); multidrug resistance-associated protein-2 (Mrp2), Abcc2; and breast cancer resistance protein (Bcrp), Abcg2].	sulforaphane	53-56	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	339-344
24948812-8	2014	The p53 inhibitor pifithrin abolished the SFN-induced increase in transporter activity/expression, and the p53-activator nutlin-3 increased P-glycoprotein activity.	sulforaphane	42-45	transformation related protein 53, pseudogene	Mus musculus	4-7
24910998-0	2014	The natural chemopreventive agent sulforaphane inhibits STAT5 activity.	sulforaphane	34-46	signal transducer and activator of transcription 5A	Homo sapiens	56-61
24910998-4	2014	We now investigated whether the dietary chemopreventive agent sulforaphane, known for its activity as deacetylase inhibitor, might also inhibit STAT5 activity and thus could act as a chemopreventive agent in STAT5-associated cancers.	sulforaphane	62-74	signal transducer and activator of transcription 5A	Homo sapiens	144-149
24910998-4	2014	We now investigated whether the dietary chemopreventive agent sulforaphane, known for its activity as deacetylase inhibitor, might also inhibit STAT5 activity and thus could act as a chemopreventive agent in STAT5-associated cancers.	sulforaphane	62-74	signal transducer and activator of transcription 5A	Homo sapiens	208-213
24910998-5	2014	We describe here sulforaphane (SFN) as a novel STAT5 inhibitor.	sulforaphane	17-29	signal transducer and activator of transcription 5A	Homo sapiens	47-52
24910998-5	2014	We describe here sulforaphane (SFN) as a novel STAT5 inhibitor.	sulforaphane	31-34	signal transducer and activator of transcription 5A	Homo sapiens	47-52
24910998-6	2014	We showed that SFN, like the deacetylase inhibitor trichostatin A (TSA), can inhibit expression of STAT5 target genes in the B cell line Ba/F3, as well as in its transformed counterpart Ba/F3-1*6 and in the human leukemic cell line K562 both of which express a constitutively active form of STAT5.	sulforaphane	15-18	signal transducer and activator of transcription 5A	Homo sapiens	99-104
24910998-6	2014	We showed that SFN, like the deacetylase inhibitor trichostatin A (TSA), can inhibit expression of STAT5 target genes in the B cell line Ba/F3, as well as in its transformed counterpart Ba/F3-1*6 and in the human leukemic cell line K562 both of which express a constitutively active form of STAT5.	sulforaphane	15-18	signal transducer and activator of transcription 5A	Homo sapiens	291-296
24910998-9	2014	Altogether, our data revealed that the natural compound sulforaphane can inhibit STAT5 downstream activity, and as such represents an attractive cancer chemoprotective agent targeting the STAT5 signaling pathway.	sulforaphane	56-68	signal transducer and activator of transcription 5A	Homo sapiens	81-86
24910998-9	2014	Altogether, our data revealed that the natural compound sulforaphane can inhibit STAT5 downstream activity, and as such represents an attractive cancer chemoprotective agent targeting the STAT5 signaling pathway.	sulforaphane	56-68	signal transducer and activator of transcription 5A	Homo sapiens	188-193
24704207-4	2014	The results presented demonstrate that exposures to the Nrf2 activators, sulforaphane (SFN) and tert-butylhydroquinone (tBHQ), markedly activate E1b transcription in human lung and liver cells.	sulforaphane	73-85	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
24704207-4	2014	The results presented demonstrate that exposures to the Nrf2 activators, sulforaphane (SFN) and tert-butylhydroquinone (tBHQ), markedly activate E1b transcription in human lung and liver cells.	sulforaphane	73-85	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	145-148
24704207-4	2014	The results presented demonstrate that exposures to the Nrf2 activators, sulforaphane (SFN) and tert-butylhydroquinone (tBHQ), markedly activate E1b transcription in human lung and liver cells.	sulforaphane	87-90	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
24704207-4	2014	The results presented demonstrate that exposures to the Nrf2 activators, sulforaphane (SFN) and tert-butylhydroquinone (tBHQ), markedly activate E1b transcription in human lung and liver cells.	sulforaphane	87-90	branched chain keto acid dehydrogenase E1 subunit beta	Homo sapiens	145-148
24704207-6	2014	In BEAS-2B cells, the Nrf2 effectors, SFN and tBHQ, selectively activated the more distal HS-2 through an antioxidant response element (ARE).	sulforaphane	38-41	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
24746830-6	2014	Sulforaphane (2.0 muM) caused an increase in LTR transcriptional activity in cultured cells.	sulforaphane	0-12	latexin	Homo sapiens	18-21
24828241-13	2014	Nrf2 is required for the cancer preventive effects of compounds such as sulforaphane, but Nrf2 can help maintain an aggressive tumor phenotype by stimulating proliferation and offering protection from chemotherapy.	sulforaphane	72-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
23784363-0	2014	Sulforaphane protects H9c2 cardiomyocytes from angiotensin II-induced hypertrophy.	sulforaphane	0-12	angiotensinogen	Rattus norvegicus	47-61
24871574-1	2014	Dietary R-sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway.	sulforaphane	8-22	kelch like ECH associated protein 1	Homo sapiens	57-62
24871574-1	2014	Dietary R-sulforaphane is a highly potent inducer of the Keap1/Nrf2/ARE pathway.	sulforaphane	8-22	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
23752191-10	2014	We examined a model of ERalpha-negative/basal-like DCIS and found that restoration of miR-140 via a genetic approach or with the dietary compound sulforaphane decreased SOX9 and ALDH1, and reduced tumor growth in vivo.	sulforaphane	146-158	estrogen receptor 1	Homo sapiens	23-30
23752191-10	2014	We examined a model of ERalpha-negative/basal-like DCIS and found that restoration of miR-140 via a genetic approach or with the dietary compound sulforaphane decreased SOX9 and ALDH1, and reduced tumor growth in vivo.	sulforaphane	146-158	microRNA 140	Homo sapiens	86-93
23752191-10	2014	We examined a model of ERalpha-negative/basal-like DCIS and found that restoration of miR-140 via a genetic approach or with the dietary compound sulforaphane decreased SOX9 and ALDH1, and reduced tumor growth in vivo.	sulforaphane	146-158	SRY-box transcription factor 9	Homo sapiens	169-173
23752191-10	2014	We examined a model of ERalpha-negative/basal-like DCIS and found that restoration of miR-140 via a genetic approach or with the dietary compound sulforaphane decreased SOX9 and ALDH1, and reduced tumor growth in vivo.	sulforaphane	146-158	aldehyde dehydrogenase 1 family member A1	Homo sapiens	178-183
23784363-3	2014	AIMS: To investigate the effect of sulforaphane on angiotensin II (Ang II)-induced cardiac hypertrophy in vitro.	sulforaphane	35-47	angiotensinogen	Rattus norvegicus	51-65
23784363-3	2014	AIMS: To investigate the effect of sulforaphane on angiotensin II (Ang II)-induced cardiac hypertrophy in vitro.	sulforaphane	35-47	angiotensinogen	Rattus norvegicus	67-73
23784363-7	2014	RESULTS: We found that H9c2 cells pretreated with sulforaphane were protected from Ang II-induced hypertrophy.	sulforaphane	50-62	angiotensinogen	Rattus norvegicus	83-89
23784363-8	2014	The increasing mRNA levels of ANP, BNP, and beta-MHC in Ang II-stimulated cells were also down-regulated after sulforaphane treatment.	sulforaphane	111-123	natriuretic peptide B	Rattus norvegicus	35-38
23784363-8	2014	The increasing mRNA levels of ANP, BNP, and beta-MHC in Ang II-stimulated cells were also down-regulated after sulforaphane treatment.	sulforaphane	111-123	angiogenin	Rattus norvegicus	56-59
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	angiotensinogen	Rattus norvegicus	37-43
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	glycogen synthase kinase 3 beta	Rattus norvegicus	76-84
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	mechanistic target of rapamycin kinase	Rattus norvegicus	86-90
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	eukaryotic translation initiation factor 4E	Rattus norvegicus	92-97
23784363-9	2014	Moreover, sulforaphane repressed the Ang II-induced phosphorylation of Akt, GSK3beta, mTOR, eIF4e, as well as of IkappaBalpha and NF-kappaB.	sulforaphane	10-22	NFKB inhibitor alpha	Rattus norvegicus	113-125
23784363-10	2014	CONCLUSION: Based on our results, sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-kappaB.	sulforaphane	34-46	angiotensinogen	Rattus norvegicus	58-64
23784363-10	2014	CONCLUSION: Based on our results, sulforaphane attenuates Ang II-induced hypertrophy of H9c2 cardiomyocytes mediated by the inhibition of intracellular signaling pathways including Akt and NF-kappaB.	sulforaphane	34-46	AKT serine/threonine kinase 1	Rattus norvegicus	181-184
24603300-0	2014	Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
24691443-4	2014	Furthermore, overexpression of proteasomal regulatory components or treatment with proteasomal activators sulforaphane (SFN) and mevalonolactone (MVA) ameliorated signaling defects in cells lacking BBS1, BBS4, and OFD1, in morphant zebrafish embryos, and in induced neurons from Ofd1-deficient mice.	sulforaphane	106-118	Bardet-Biedl syndrome 1	Danio rerio	198-202
24691443-4	2014	Furthermore, overexpression of proteasomal regulatory components or treatment with proteasomal activators sulforaphane (SFN) and mevalonolactone (MVA) ameliorated signaling defects in cells lacking BBS1, BBS4, and OFD1, in morphant zebrafish embryos, and in induced neurons from Ofd1-deficient mice.	sulforaphane	106-118	Bardet-Biedl syndrome 4	Danio rerio	204-208
24691443-4	2014	Furthermore, overexpression of proteasomal regulatory components or treatment with proteasomal activators sulforaphane (SFN) and mevalonolactone (MVA) ameliorated signaling defects in cells lacking BBS1, BBS4, and OFD1, in morphant zebrafish embryos, and in induced neurons from Ofd1-deficient mice.	sulforaphane	106-118	OFD1 centriole and centriolar satellite protein	Danio rerio	214-218
24691443-4	2014	Furthermore, overexpression of proteasomal regulatory components or treatment with proteasomal activators sulforaphane (SFN) and mevalonolactone (MVA) ameliorated signaling defects in cells lacking BBS1, BBS4, and OFD1, in morphant zebrafish embryos, and in induced neurons from Ofd1-deficient mice.	sulforaphane	120-123	Bardet-Biedl syndrome 1	Danio rerio	198-202
24691443-4	2014	Furthermore, overexpression of proteasomal regulatory components or treatment with proteasomal activators sulforaphane (SFN) and mevalonolactone (MVA) ameliorated signaling defects in cells lacking BBS1, BBS4, and OFD1, in morphant zebrafish embryos, and in induced neurons from Ofd1-deficient mice.	sulforaphane	120-123	Bardet-Biedl syndrome 4	Danio rerio	204-208
24691443-4	2014	Furthermore, overexpression of proteasomal regulatory components or treatment with proteasomal activators sulforaphane (SFN) and mevalonolactone (MVA) ameliorated signaling defects in cells lacking BBS1, BBS4, and OFD1, in morphant zebrafish embryos, and in induced neurons from Ofd1-deficient mice.	sulforaphane	120-123	OFD1 centriole and centriolar satellite protein	Danio rerio	214-218
24691443-6	2014	We found that loss of BBS1, BBS4, or OFD1 led to decreased NF-kappaB activity and concomitant IkappaBbeta accumulation and that these defects were ameliorated with SFN treatment.	sulforaphane	164-167	Bardet-Biedl syndrome 1	Homo sapiens	22-26
24691443-6	2014	We found that loss of BBS1, BBS4, or OFD1 led to decreased NF-kappaB activity and concomitant IkappaBbeta accumulation and that these defects were ameliorated with SFN treatment.	sulforaphane	164-167	Bardet-Biedl syndrome 4	Homo sapiens	28-32
24691443-6	2014	We found that loss of BBS1, BBS4, or OFD1 led to decreased NF-kappaB activity and concomitant IkappaBbeta accumulation and that these defects were ameliorated with SFN treatment.	sulforaphane	164-167	OFD1 centriole and centriolar satellite protein	Homo sapiens	37-41
24691443-6	2014	We found that loss of BBS1, BBS4, or OFD1 led to decreased NF-kappaB activity and concomitant IkappaBbeta accumulation and that these defects were ameliorated with SFN treatment.	sulforaphane	164-167	NFKB inhibitor beta	Homo sapiens	94-105
24383989-7	2014	To further examine whether sulforaphane promotes mutant huntingtin (mHtt) degradation, we treated Huntington"s disease cells with sulforaphane and found that sulforaphane not only enhanced mHtt degradation but also reduced mHtt cytotoxicity.	sulforaphane	27-39	huntingtin	Mus musculus	56-66
24603300-2	2014	Cellular protection from free radicals can be stimulated several fold by sulforaphane-mediated activation of the transcription factor Nrf2 that regulates more than 50 genes involved in the detoxification of reactive substances and radicals.	sulforaphane	73-85	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
24603300-5	2014	Fibroblasts exposed to repeated-sulforaphane treatment showed a more pronounced dose-dependent induction of Nrf2-regulated mRNA and reduced amount of radiation-induced free radicals compared with cells treated once with sulforaphane.	sulforaphane	32-44	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
24603300-8	2014	Sulforaphane treatment was unable to protect Nrf2 knockout mouse embryonic fibroblasts, indicating that the sulforaphane-induced radioprotection was Nrf2-dependent.	sulforaphane	108-120	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
24691097-5	2014	Therefore, the activation of NRF2 signaling with sulforaphane effectively attenuated the TGFbeta1-stimulated increase in fibronectin-1 and collagen 1A1.	sulforaphane	49-61	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
23611476-13	2014	CONCLUSION: Topically applied SFN in the PEG base formulation significantly reduced AP-1 activation after UV stimulation in the skin of a transgenic mouse model, indicating that SFN in this formulation retains efficacy in vivo.	sulforaphane	30-33	jun proto-oncogene	Mus musculus	84-88
24170324-8	2014	The cell-free extract of E. coli VL8 containing the reductase enzyme was able to reduce both the GSL glucoraphanin and its hydrolysis product sulforaphane to glucoerucin and erucin/erucin NIT, respectively.	sulforaphane	142-154	cathepsin A	Homo sapiens	97-100
24626333-10	2014	These findings suggest that sulforaphane shifts the balance from TRAIL-induced survival signals to apoptosis and thus explains the observed synergistic effect.	sulforaphane	28-40	TNF superfamily member 10	Homo sapiens	65-70
24626333-11	2014	A nutritional strategy for high sulforaphane intake may target the cancer-specific activity of TRAIL in CSCs.	sulforaphane	32-44	TNF superfamily member 10	Homo sapiens	95-100
24639357-0	2014	Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.	sulforaphane	0-12	interleukin 23, alpha subunit p19	Mus musculus	79-84
24639357-7	2014	In contrast, SFN treatment of dendritic cells (DCs) inhibited TLR4-induced IL-12 and IL-23 production, and severely suppressed Th1 and Th17 development of T cells primed by SFN-treated DCs.	sulforaphane	13-16	toll-like receptor 4	Mus musculus	62-66
24639357-7	2014	In contrast, SFN treatment of dendritic cells (DCs) inhibited TLR4-induced IL-12 and IL-23 production, and severely suppressed Th1 and Th17 development of T cells primed by SFN-treated DCs.	sulforaphane	13-16	interleukin 23, alpha subunit p19	Mus musculus	85-90
24639357-7	2014	In contrast, SFN treatment of dendritic cells (DCs) inhibited TLR4-induced IL-12 and IL-23 production, and severely suppressed Th1 and Th17 development of T cells primed by SFN-treated DCs.	sulforaphane	13-16	negative elongation factor complex member C/D, Th1l	Mus musculus	127-130
24639357-7	2014	In contrast, SFN treatment of dendritic cells (DCs) inhibited TLR4-induced IL-12 and IL-23 production, and severely suppressed Th1 and Th17 development of T cells primed by SFN-treated DCs.	sulforaphane	173-176	interleukin 23, alpha subunit p19	Mus musculus	85-90
24639357-7	2014	In contrast, SFN treatment of dendritic cells (DCs) inhibited TLR4-induced IL-12 and IL-23 production, and severely suppressed Th1 and Th17 development of T cells primed by SFN-treated DCs.	sulforaphane	173-176	negative elongation factor complex member C/D, Th1l	Mus musculus	127-130
24092501-0	2014	Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells.	sulforaphane	24-40	vimentin	Homo sapiens	63-71
24092501-0	2014	Functional relevance of D,L-sulforaphane-mediated induction of vimentin and plasminogen activator inhibitor-1 in human prostate cancer cells.	sulforaphane	24-40	serpin family E member 1	Homo sapiens	76-109
24092501-1	2014	PURPOSE: D,L-Sulforaphane (SFN) is a promising chemopreventive agent with in vivo efficacy against prostate cancer in experimental rodents.	sulforaphane	9-25	RNA exonuclease 2	Homo sapiens	27-30
24691097-5	2014	Therefore, the activation of NRF2 signaling with sulforaphane effectively attenuated the TGFbeta1-stimulated increase in fibronectin-1 and collagen 1A1.	sulforaphane	49-61	transforming growth factor beta 1	Homo sapiens	89-97
24691097-5	2014	Therefore, the activation of NRF2 signaling with sulforaphane effectively attenuated the TGFbeta1-stimulated increase in fibronectin-1 and collagen 1A1.	sulforaphane	49-61	fibronectin 1	Homo sapiens	121-134
24969711-14	2014	Sulforaphane could inhibit the TLR4/MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD.	sulforaphane	129-141	MYD88 innate immune signal transduction adaptor	Homo sapiens	36-41
24742583-0	2014	Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication.	sulforaphane	0-12	gap junction protein alpha 1	Homo sapiens	84-88
24742583-7	2014	The bioactive substance sulforaphane enhanced Cx43 and E-cadherin levels, inhibited the CSC markers c-Met and CD133, improved the functional morphology of GJs and enhanced GJIC.	sulforaphane	24-36	gap junction protein alpha 1	Homo sapiens	46-50
24742583-7	2014	The bioactive substance sulforaphane enhanced Cx43 and E-cadherin levels, inhibited the CSC markers c-Met and CD133, improved the functional morphology of GJs and enhanced GJIC.	sulforaphane	24-36	cadherin 1	Homo sapiens	55-65
24742583-7	2014	The bioactive substance sulforaphane enhanced Cx43 and E-cadherin levels, inhibited the CSC markers c-Met and CD133, improved the functional morphology of GJs and enhanced GJIC.	sulforaphane	24-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	100-105
24742583-8	2014	Sulforaphane altered the phosphorylation of several kinases and their substrates and inhibition of GSK3, JNK and PKC prevented sulforaphane-induced CX43 expression.	sulforaphane	127-139	mitogen-activated protein kinase 8	Homo sapiens	105-108
24742583-8	2014	Sulforaphane altered the phosphorylation of several kinases and their substrates and inhibition of GSK3, JNK and PKC prevented sulforaphane-induced CX43 expression.	sulforaphane	127-139	gap junction protein alpha 1	Homo sapiens	148-152
24742583-9	2014	The sulforaphane-mediated expression of Cx43 was not correlated with enhanced Cx43 RNA expression, acetylated histone binding and Cx43 promoter de-methylation, suggesting that posttranslational phosphorylation is the dominant regulatory mechanism.	sulforaphane	4-16	gap junction protein alpha 1	Homo sapiens	40-44
24969711-0	2014	[Effects of sulforaphane on Toll-like receptor 4/myeloid differentiation factor 88 pathway of monocyte-derived macrophages from patients with chronic obstructive pulmonary disease].	sulforaphane	12-24	toll like receptor 4	Homo sapiens	28-48
24969711-14	2014	Sulforaphane could inhibit the TLR4/MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD.	sulforaphane	129-141	COPD	Homo sapiens	182-186
24667842-0	2014	Sulforaphane induces oxidative stress and death by p53-independent mechanism: implication of impaired glutathione recycling.	sulforaphane	0-12	tumor protein p53	Homo sapiens	51-54
24969711-1	2014	OBJECTIVE: To explore the effects of sulforaphane on Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway and its downstream inflammatory cytokines in patients with chronic obstructive pulmonary disease (COPD).	sulforaphane	37-49	toll like receptor 4	Homo sapiens	53-73
24969711-1	2014	OBJECTIVE: To explore the effects of sulforaphane on Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway and its downstream inflammatory cytokines in patients with chronic obstructive pulmonary disease (COPD).	sulforaphane	37-49	toll like receptor 4	Homo sapiens	75-79
24969711-1	2014	OBJECTIVE: To explore the effects of sulforaphane on Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway and its downstream inflammatory cytokines in patients with chronic obstructive pulmonary disease (COPD).	sulforaphane	37-49	MYD88 innate immune signal transduction adaptor	Homo sapiens	116-121
24969711-1	2014	OBJECTIVE: To explore the effects of sulforaphane on Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88) pathway and its downstream inflammatory cytokines in patients with chronic obstructive pulmonary disease (COPD).	sulforaphane	37-49	COPD	Homo sapiens	229-233
24969711-14	2014	Sulforaphane could inhibit the TLR4/MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD.	sulforaphane	0-12	toll like receptor 4	Homo sapiens	31-35
24969711-14	2014	Sulforaphane could inhibit the TLR4/MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD.	sulforaphane	0-12	MYD88 innate immune signal transduction adaptor	Homo sapiens	36-41
24969711-14	2014	Sulforaphane could inhibit the TLR4/MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD.	sulforaphane	0-12	COPD	Homo sapiens	182-186
24969711-14	2014	Sulforaphane could inhibit the TLR4/MyD88 pathway and reduce the releasing of downstream inflammatory cytokines, suggesting that sulforaphane may have an anti-inflammatory effect in COPD.	sulforaphane	129-141	toll like receptor 4	Homo sapiens	31-35
24667842-5	2014	MG-63 cells were exposed to SFN for up to 48 h. At 10 muM concentration or higher, SFN decreased cell viability, increased the%early apoptotic cells and increased caspase 3 activity.	sulforaphane	83-86	caspase 3	Homo sapiens	163-172
24667842-9	2014	In conclusion, SFN induced oxidative stress and apoptosis via a p53-independent mechanism.	sulforaphane	15-18	tumor protein p53	Homo sapiens	64-67
24637114-5	2014	Timed administration of sulforaphane, an NRF2 activator, significantly blocked this phenotype.	sulforaphane	24-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
24734194-12	2014	This is the first demonstration that SF modulates the metabolism of AA by both P450 enzymes and sEH in SHR rats.	sulforaphane	37-39	epoxide hydrolase 2	Rattus norvegicus	96-99
24352536-1	2014	The isothiocyanate sulforaphane (SFN), the major hydrolysis product of glucosinolates present in broccoli, has frequently been proposed to exert anticarcinogenic properties, mainly due to the induction of the nrf2/Keap1/ARE-signaling pathway.	sulforaphane	33-36	NFE2 like bZIP transcription factor 2	Homo sapiens	209-213
24352536-1	2014	The isothiocyanate sulforaphane (SFN), the major hydrolysis product of glucosinolates present in broccoli, has frequently been proposed to exert anticarcinogenic properties, mainly due to the induction of the nrf2/Keap1/ARE-signaling pathway.	sulforaphane	33-36	kelch like ECH associated protein 1	Homo sapiens	214-219
24352536-4	2014	Within this study, a SFN-induced deliberation of zinc from a synthesized peptide resembling the zinc binding domain of the xeroderma pigmentosum A (XPA) protein was observed starting at 50 muM SFN.	sulforaphane	21-24	XPA, DNA damage recognition and repair factor	Homo sapiens	123-146
24352536-4	2014	Within this study, a SFN-induced deliberation of zinc from a synthesized peptide resembling the zinc binding domain of the xeroderma pigmentosum A (XPA) protein was observed starting at 50 muM SFN.	sulforaphane	21-24	XPA, DNA damage recognition and repair factor	Homo sapiens	148-151
24352536-4	2014	Within this study, a SFN-induced deliberation of zinc from a synthesized peptide resembling the zinc binding domain of the xeroderma pigmentosum A (XPA) protein was observed starting at 50 muM SFN.	sulforaphane	193-196	XPA, DNA damage recognition and repair factor	Homo sapiens	123-146
24352536-4	2014	Within this study, a SFN-induced deliberation of zinc from a synthesized peptide resembling the zinc binding domain of the xeroderma pigmentosum A (XPA) protein was observed starting at 50 muM SFN.	sulforaphane	193-196	XPA, DNA damage recognition and repair factor	Homo sapiens	148-151
24352536-8	2014	In support of an inactivation of XPA also in cells, SFN increased the (+)-anti-BPDE-induced cytotoxicity XPA dependently in XP12RO cells.	sulforaphane	52-55	XPA, DNA damage recognition and repair factor	Homo sapiens	33-36
24352536-8	2014	In support of an inactivation of XPA also in cells, SFN increased the (+)-anti-BPDE-induced cytotoxicity XPA dependently in XP12RO cells.	sulforaphane	52-55	XPA, DNA damage recognition and repair factor	Homo sapiens	105-108
24441674-0	2014	Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane.	sulforaphane	129-141	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	sulforaphane	69-72	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	sulforaphane	69-72	nuclear factor, erythroid derived 2, like 2	Mus musculus	46-50
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	sulforaphane	69-72	heme oxygenase 1	Mus musculus	52-56
24441674-9	2014	Collectively, these results suggest that the anti-cancer effect of SFN against TPA-induced neoplastic transformation of mouse skin could involve the epigenetic reprogramming of anti-cancer genes such as Nrf2, leading to the epigenetic reactivation of Nrf2 and the subsequent induction of downstream target genes involved in cellular protection.	sulforaphane	67-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	203-207
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	sulforaphane	69-72	NAD(P)H dehydrogenase, quinone 1	Mus musculus	61-65
24441674-5	2014	Knockdown of Nrf2 attenuated the induction of Nrf2, HO-1 and NQO1 by SFN, enhanced TPA-induced colony formation and dampened the inhibitory effect of SFN on TPA-induced JB6 transformation.	sulforaphane	150-153	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24441674-9	2014	Collectively, these results suggest that the anti-cancer effect of SFN against TPA-induced neoplastic transformation of mouse skin could involve the epigenetic reprogramming of anti-cancer genes such as Nrf2, leading to the epigenetic reactivation of Nrf2 and the subsequent induction of downstream target genes involved in cellular protection.	sulforaphane	67-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	251-255
24465597-6	2014	RESULTS: Celastrol, resveratrol, sulphoraphane and curcumin inhibited the NF-kappaB promoter activity significantly and in a dose dependent manner.	sulforaphane	33-46	nuclear factor kappa B subunit 1	Homo sapiens	74-83
24587385-0	2014	Sulforaphane inhibits invasion via activating ERK1/2 signaling in human glioblastoma U87MG and U373MG cells.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	46-52
24587385-17	2014	SFN might be a potential therapeutic agent by activating ERK1/2 signaling against human glioblastoma.	sulforaphane	0-3	mitogen-activated protein kinase 3	Homo sapiens	57-63
24559113-2	2014	Dietary components such as sulforaphane in broccoli and quercetin in onions have been shown to be inducers of Nrf2.	sulforaphane	27-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
24296129-3	2014	The sulforaphane-induced mitotic arrest correlated with an induction of cyclin B1 and phosphorylation of Cdk1, as well as a concomitant increased complex between cyclin B1 and Cdk1.	sulforaphane	4-16	cyclin B1	Homo sapiens	72-81
24296129-3	2014	The sulforaphane-induced mitotic arrest correlated with an induction of cyclin B1 and phosphorylation of Cdk1, as well as a concomitant increased complex between cyclin B1 and Cdk1.	sulforaphane	4-16	cyclin dependent kinase 1	Homo sapiens	105-109
24296129-3	2014	The sulforaphane-induced mitotic arrest correlated with an induction of cyclin B1 and phosphorylation of Cdk1, as well as a concomitant increased complex between cyclin B1 and Cdk1.	sulforaphane	4-16	cyclin B1	Homo sapiens	162-171
24296129-3	2014	The sulforaphane-induced mitotic arrest correlated with an induction of cyclin B1 and phosphorylation of Cdk1, as well as a concomitant increased complex between cyclin B1 and Cdk1.	sulforaphane	4-16	cyclin dependent kinase 1	Homo sapiens	176-180
24296129-4	2014	Sulforaphane-induced apoptosis was associated with the activation of caspase-8 and -9, the initiators caspases of the extrinsic and intrinsic apoptotic pathways, respectively, and activation of effector caspase-3 and cleavage of poly (ADP-ribose) polymerase.	sulforaphane	0-12	caspase 8	Homo sapiens	69-85
24296129-4	2014	Sulforaphane-induced apoptosis was associated with the activation of caspase-8 and -9, the initiators caspases of the extrinsic and intrinsic apoptotic pathways, respectively, and activation of effector caspase-3 and cleavage of poly (ADP-ribose) polymerase.	sulforaphane	0-12	caspase 3	Homo sapiens	203-212
24296129-4	2014	Sulforaphane-induced apoptosis was associated with the activation of caspase-8 and -9, the initiators caspases of the extrinsic and intrinsic apoptotic pathways, respectively, and activation of effector caspase-3 and cleavage of poly (ADP-ribose) polymerase.	sulforaphane	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	229-257
24025640-6	2014	In addition, Nrf2(+/+) mice showed ameliorative renal function when treated with sulforaphane, an Nrf2 inducer.	sulforaphane	81-93	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
24025640-6	2014	In addition, Nrf2(+/+) mice showed ameliorative renal function when treated with sulforaphane, an Nrf2 inducer.	sulforaphane	81-93	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
24333359-6	2014	Sulforaphane (SF) was used to activate Nrf2-ARE signal pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
24333359-6	2014	Sulforaphane (SF) was used to activate Nrf2-ARE signal pathway.	sulforaphane	14-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-43
24297178-4	2014	We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation.	sulforaphane	45-57	aldehyde dehydrogenase 1 family member A1	Homo sapiens	104-128
24297178-4	2014	We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation.	sulforaphane	45-57	aldehyde dehydrogenase 1 family member A1	Homo sapiens	130-135
24060752-0	2014	Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
24416372-0	2014	SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.	sulforaphane	10-22	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
24416372-0	2014	SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.	sulforaphane	10-22	sequestosome 1	Homo sapiens	115-118
24416372-0	2014	SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.	sulforaphane	10-22	sequestosome 1	Homo sapiens	119-125
24416372-4	2014	Sulforaphane, an isothiocyanate derived from cruciferous vegetables, is a potent inducer of KEAP1-NRF2 signaling and antioxidant response element driven gene expression.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	92-97
24416372-4	2014	Sulforaphane, an isothiocyanate derived from cruciferous vegetables, is a potent inducer of KEAP1-NRF2 signaling and antioxidant response element driven gene expression.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
24416372-5	2014	In this study, we show that sulforaphane enhances the expression of the transcriptional coregulator SPBP.	sulforaphane	28-40	transcription factor 20	Homo sapiens	100-104
24416372-6	2014	The expression curve peaks 6-8 hours post stimulation, and parallels the sulforaphane-induced expression of NRF2 and the autophagy receptor protein p62/SQSTM1.	sulforaphane	73-85	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
24416372-6	2014	The expression curve peaks 6-8 hours post stimulation, and parallels the sulforaphane-induced expression of NRF2 and the autophagy receptor protein p62/SQSTM1.	sulforaphane	73-85	sequestosome 1	Homo sapiens	148-151
24416372-6	2014	The expression curve peaks 6-8 hours post stimulation, and parallels the sulforaphane-induced expression of NRF2 and the autophagy receptor protein p62/SQSTM1.	sulforaphane	73-85	sequestosome 1	Homo sapiens	152-158
24416372-8	2014	Furthermore, SPBP siRNA reduces the sulforaphane induced expression of NRF2, and the expression of the autophagy marker protein LC3B.	sulforaphane	36-48	transcription factor 20	Homo sapiens	13-17
24416372-8	2014	Furthermore, SPBP siRNA reduces the sulforaphane induced expression of NRF2, and the expression of the autophagy marker protein LC3B.	sulforaphane	36-48	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
24416372-0	2014	SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.	sulforaphane	10-22	transcription factor 20	Homo sapiens	0-4
24641360-0	2014	Sulforaphane inhibits the proliferation of the BIU87 bladder cancer cell line via IGFBP-3 elevation.	sulforaphane	0-12	insulin like growth factor binding protein 3	Homo sapiens	82-89
24641360-2	2014	METHODS: Both BIU87 and IGFBP-3-silenced BIU87 cells were treated with sulforaphane.	sulforaphane	71-83	insulin like growth factor binding protein 3	Homo sapiens	24-31
24641360-6	2014	RESULTS: Sulforaphane (80 muM) treatment could inhibit cell proliferation, inducing apoptosis and cell cycle arrest at G2/M phase.	sulforaphane	9-21	latexin	Homo sapiens	26-29
24641360-8	2014	Furthermore, sulforaphane (80 muM) could down-regulate NF-kappaB expression while elevating that of IGFBP-3.	sulforaphane	13-25	latexin	Homo sapiens	30-33
24641360-8	2014	Furthermore, sulforaphane (80 muM) could down-regulate NF-kappaB expression while elevating that of IGFBP-3.	sulforaphane	13-25	nuclear factor kappa B subunit 1	Homo sapiens	55-64
24641360-8	2014	Furthermore, sulforaphane (80 muM) could down-regulate NF-kappaB expression while elevating that of IGFBP-3.	sulforaphane	13-25	insulin like growth factor binding protein 3	Homo sapiens	100-107
24641360-9	2014	CONCLUSIONS: Sulforaphane could suppress the proliferation of BIU87 cells via enhancing IGFBP-3 expression, which negatively regulating the NF-kappaB signaling pathway.	sulforaphane	13-25	insulin like growth factor binding protein 3	Homo sapiens	88-95
24641360-9	2014	CONCLUSIONS: Sulforaphane could suppress the proliferation of BIU87 cells via enhancing IGFBP-3 expression, which negatively regulating the NF-kappaB signaling pathway.	sulforaphane	13-25	nuclear factor kappa B subunit 1	Homo sapiens	140-149
24060752-0	2014	Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis.	sulforaphane	0-12	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	47-53
24060752-4	2014	METHOD: The current study was designed to evaluate the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.	sulforaphane	66-78	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
24060752-4	2014	METHOD: The current study was designed to evaluate the ability of sulforaphane, an activator of Nrf2, to blunt CYP2E1-dependent, ethanol-induced steatosis in vivo and in vitro.	sulforaphane	66-78	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	111-117
24060752-5	2014	RESULTS: The sulforaphane treatment activated Nrf2, increased levels of the Nrf2 target heme oxygenase-1 and subsequently lowered oxidant stress as shown by the decline in lipid peroxidation and 3-nitrotyrosine protein adducts and an increase in GSH levels after the acute ethanol treatment.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
24060752-5	2014	RESULTS: The sulforaphane treatment activated Nrf2, increased levels of the Nrf2 target heme oxygenase-1 and subsequently lowered oxidant stress as shown by the decline in lipid peroxidation and 3-nitrotyrosine protein adducts and an increase in GSH levels after the acute ethanol treatment.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
24060752-5	2014	RESULTS: The sulforaphane treatment activated Nrf2, increased levels of the Nrf2 target heme oxygenase-1 and subsequently lowered oxidant stress as shown by the decline in lipid peroxidation and 3-nitrotyrosine protein adducts and an increase in GSH levels after the acute ethanol treatment.	sulforaphane	13-25	heme oxygenase 1	Homo sapiens	88-104
24060752-7	2014	Similar results were found in vitro as addition of sulforaphane to HepG2 E47 cells, which express CYP2E1, elevated Nrf2 levels and decreased the accumulation of lipid in cells cultured with ethanol.	sulforaphane	51-63	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	98-104
24060752-7	2014	Similar results were found in vitro as addition of sulforaphane to HepG2 E47 cells, which express CYP2E1, elevated Nrf2 levels and decreased the accumulation of lipid in cells cultured with ethanol.	sulforaphane	51-63	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
24139870-6	2014	Sulforaphane, an inducer of Nrf2 was given to timed pregnant mice to determine if in utero exposure attenuated p21 and IL-6 gene expression in wildtype neonatal mice exposed to hyperoxia.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
24287881-4	2014	SFN is capable of inducing an antioxidant and phase II response via activation of the nuclear transcription factor (erythroid-derived 2)-like 2 (Nrf2).	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
24405297-3	2014	In this work, the MG-63 osteosarcoma cell line was exposed to SFN up to 20 muM for 24 and 48 h. SFN induced G2/M phase arrest and decreased nuclear division index, associated with disruption of cytoskeletal organization.	sulforaphane	62-65	latexin	Homo sapiens	75-78
24405297-3	2014	In this work, the MG-63 osteosarcoma cell line was exposed to SFN up to 20 muM for 24 and 48 h. SFN induced G2/M phase arrest and decreased nuclear division index, associated with disruption of cytoskeletal organization.	sulforaphane	96-99	latexin	Homo sapiens	75-78
24405297-5	2014	After 48-h exposure, SFN at a dietary concentration (5 muM) contributed to genomic instability in the MG-63 cells as confirmed by increased number of DNA breaks, clastogenicity, and nuclear and mitotic abnormalities.	sulforaphane	21-24	latexin	Homo sapiens	55-58
24707343-0	2014	Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
24707343-4	2014	Sulforaphane protects against oxidative damage by increasing Nrf2 expression and its downstream target genes.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
24707343-8	2014	However, these pathological changes were significantly attenuated by sulforaphane treatment that was associated with a significant upregulation of Nrf2 expression and function.	sulforaphane	69-81	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
24707343-9	2014	These results suggest that sulforaphane is able to upregulate aortic Nrf2 expression and function and to protect the aorta from T2DM-induced pathological changes.	sulforaphane	27-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	69-73
24120440-5	2013	Furthermore, the protection of SFN was also related to decreased levels of oxidative stress in the brains of mice by enhanced activation of the Nrf2/ARE pathway and increased levels of anti-oxidant HO-1 and NQO1 expression.	sulforaphane	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
23389114-5	2013	Cell viability and ultrastructure, protein synthesis, autophagy induction and phosphorylation status of Akt and S6K1 kinases upon SFN treatment were determined.	sulforaphane	130-133	AKT serine/threonine kinase 1	Homo sapiens	104-107
23389114-5	2013	Cell viability and ultrastructure, protein synthesis, autophagy induction and phosphorylation status of Akt and S6K1 kinases upon SFN treatment were determined.	sulforaphane	130-133	ribosomal protein S6 kinase B1	Homo sapiens	112-116
23389114-9	2013	CONCLUSION: These results indicate that SFN is a potent inhibitor of the viability of breast cancer cells representing different activity of the ErbB2/ER-PI3K-Akt-mTOR-S6K1 [corrected] pro-survival pathway and suggest that it targets downstream elements of the pathway.	sulforaphane	40-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-150
23389114-9	2013	CONCLUSION: These results indicate that SFN is a potent inhibitor of the viability of breast cancer cells representing different activity of the ErbB2/ER-PI3K-Akt-mTOR-S6K1 [corrected] pro-survival pathway and suggest that it targets downstream elements of the pathway.	sulforaphane	40-43	AKT serine/threonine kinase 1	Homo sapiens	159-162
23389114-9	2013	CONCLUSION: These results indicate that SFN is a potent inhibitor of the viability of breast cancer cells representing different activity of the ErbB2/ER-PI3K-Akt-mTOR-S6K1 [corrected] pro-survival pathway and suggest that it targets downstream elements of the pathway.	sulforaphane	40-43	mechanistic target of rapamycin kinase	Homo sapiens	163-167
23389114-9	2013	CONCLUSION: These results indicate that SFN is a potent inhibitor of the viability of breast cancer cells representing different activity of the ErbB2/ER-PI3K-Akt-mTOR-S6K1 [corrected] pro-survival pathway and suggest that it targets downstream elements of the pathway.	sulforaphane	40-43	ribosomal protein S6 kinase B1	Homo sapiens	168-172
24184564-0	2014	Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.	sulforaphane	12-24	NAD(P)H dehydrogenase, quinone 1	Mus musculus	74-104
24184564-0	2014	Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.	sulforaphane	12-24	NAD(P)H dehydrogenase, quinone 1	Mus musculus	106-110
24184564-0	2014	Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.	sulforaphane	12-24	NAD(P)H dehydrogenase, quinone 1	Mus musculus	144-148
24184564-0	2014	Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure.	sulforaphane	12-24	hematopoietic prostaglandin D synthase	Mus musculus	150-175
24184564-1	2014	The study objective was to determine if maternal administration of sulforaphane (SFN) induced Nrf2-controlled genes.	sulforaphane	67-79	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
24184564-1	2014	The study objective was to determine if maternal administration of sulforaphane (SFN) induced Nrf2-controlled genes.	sulforaphane	81-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
24184564-2	2014	In acute studies, when non-pregnant and pregnant mice were orally exposed to SFN (50 or 100 mg/kg) on gestational day (GD) 14 and euthanized after 2, 6 or 24h, results demonstrated increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels in adult liver, but no change in NQO1 activity.	sulforaphane	77-80	glutathione S-transferase, mu 1	Mus musculus	191-196
24184564-2	2014	In acute studies, when non-pregnant and pregnant mice were orally exposed to SFN (50 or 100 mg/kg) on gestational day (GD) 14 and euthanized after 2, 6 or 24h, results demonstrated increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels in adult liver, but no change in NQO1 activity.	sulforaphane	77-80	NAD(P)H dehydrogenase, quinone 1	Mus musculus	198-202
24184564-2	2014	In acute studies, when non-pregnant and pregnant mice were orally exposed to SFN (50 or 100 mg/kg) on gestational day (GD) 14 and euthanized after 2, 6 or 24h, results demonstrated increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels in adult liver, but no change in NQO1 activity.	sulforaphane	77-80	heme oxygenase 1	Mus musculus	204-208
24184564-2	2014	In acute studies, when non-pregnant and pregnant mice were orally exposed to SFN (50 or 100 mg/kg) on gestational day (GD) 14 and euthanized after 2, 6 or 24h, results demonstrated increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels in adult liver, but no change in NQO1 activity.	sulforaphane	77-80	glutamate-cysteine ligase, catalytic subunit	Mus musculus	214-218
24184564-2	2014	In acute studies, when non-pregnant and pregnant mice were orally exposed to SFN (50 or 100 mg/kg) on gestational day (GD) 14 and euthanized after 2, 6 or 24h, results demonstrated increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels in adult liver, but no change in NQO1 activity.	sulforaphane	77-80	NAD(P)H dehydrogenase, quinone 1	Mus musculus	275-279
24184564-3	2014	In sub-chronic studies, when non-pregnant and pregnant mice were orally exposed to SFN (65 mg/kg) daily for 30 days and euthanized on GD14, results demonstrated a 2- to 3-fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2-fold increase in NQO1 activity in adult livers.	sulforaphane	83-86	glutathione S-transferase, mu 1	Mus musculus	188-193
24184564-3	2014	In sub-chronic studies, when non-pregnant and pregnant mice were orally exposed to SFN (65 mg/kg) daily for 30 days and euthanized on GD14, results demonstrated a 2- to 3-fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2-fold increase in NQO1 activity in adult livers.	sulforaphane	83-86	glutamate-cysteine ligase, catalytic subunit	Mus musculus	195-199
24184564-3	2014	In sub-chronic studies, when non-pregnant and pregnant mice were orally exposed to SFN (65 mg/kg) daily for 30 days and euthanized on GD14, results demonstrated a 2- to 3-fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2-fold increase in NQO1 activity in adult livers.	sulforaphane	83-86	NAD(P)H dehydrogenase, quinone 1	Mus musculus	204-208
24184564-3	2014	In sub-chronic studies, when non-pregnant and pregnant mice were orally exposed to SFN (65 mg/kg) daily for 30 days and euthanized on GD14, results demonstrated a 2- to 3-fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2-fold increase in NQO1 activity in adult livers.	sulforaphane	83-86	NAD(P)H dehydrogenase, quinone 1	Mus musculus	253-257
24004877-6	2013	Sulforaphane post-irradiation treatment enhanced the CD 34(+)Lin(-) cell population in culture.	sulforaphane	0-12	CD34 molecule	Homo sapiens	53-58
24349480-7	2013	In particular, to gain insight into the cardioprotective role of the modulation of glyoxalase 1 by sulforaphane, further experiments were performed using methylglyoxal to mimic glycative stress.	sulforaphane	99-111	glyoxalase 1	Rattus norvegicus	83-95
24349480-8	2013	Sulforaphane was able to counteract methylglyoxal-induced apoptosis, ROS production, and glycative stress, likely through glyoxalase 1 up-regulation.	sulforaphane	0-12	glyoxalase 1	Rattus norvegicus	122-134
24349480-9	2013	In this study, we reported for the first time new molecular targets of sulforaphane, such as MIF, CLP36 and glyoxalase 1.	sulforaphane	71-83	macrophage migration inhibitory factor	Rattus norvegicus	93-96
24349480-9	2013	In this study, we reported for the first time new molecular targets of sulforaphane, such as MIF, CLP36 and glyoxalase 1.	sulforaphane	71-83	PDZ and LIM domain 1	Rattus norvegicus	98-103
24349480-9	2013	In this study, we reported for the first time new molecular targets of sulforaphane, such as MIF, CLP36 and glyoxalase 1.	sulforaphane	71-83	glyoxalase 1	Rattus norvegicus	108-120
23389114-3	2013	Since epidemiologic as well as rodent tumor studies indicate that sulforaphane (SFN), a constituent of many edible cruciferous vegetables, might be a potent inhibitor of mammary carcinogenesis, we analyzed the response of four breast cancer cell lines representing different abnormalities in ErbB2/ER-PI3K-Akt-mTOR-S6K1[corrected] signaling pathway to this compound.	sulforaphane	66-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	292-297
23389114-3	2013	Since epidemiologic as well as rodent tumor studies indicate that sulforaphane (SFN), a constituent of many edible cruciferous vegetables, might be a potent inhibitor of mammary carcinogenesis, we analyzed the response of four breast cancer cell lines representing different abnormalities in ErbB2/ER-PI3K-Akt-mTOR-S6K1[corrected] signaling pathway to this compound.	sulforaphane	66-78	AKT serine/threonine kinase 1	Homo sapiens	306-309
23389114-3	2013	Since epidemiologic as well as rodent tumor studies indicate that sulforaphane (SFN), a constituent of many edible cruciferous vegetables, might be a potent inhibitor of mammary carcinogenesis, we analyzed the response of four breast cancer cell lines representing different abnormalities in ErbB2/ER-PI3K-Akt-mTOR-S6K1[corrected] signaling pathway to this compound.	sulforaphane	66-78	mechanistic target of rapamycin kinase	Homo sapiens	310-314
23389114-3	2013	Since epidemiologic as well as rodent tumor studies indicate that sulforaphane (SFN), a constituent of many edible cruciferous vegetables, might be a potent inhibitor of mammary carcinogenesis, we analyzed the response of four breast cancer cell lines representing different abnormalities in ErbB2/ER-PI3K-Akt-mTOR-S6K1[corrected] signaling pathway to this compound.	sulforaphane	66-78	ribosomal protein S6 kinase B1	Homo sapiens	315-319
24120440-5	2013	Furthermore, the protection of SFN was also related to decreased levels of oxidative stress in the brains of mice by enhanced activation of the Nrf2/ARE pathway and increased levels of anti-oxidant HO-1 and NQO1 expression.	sulforaphane	31-34	heme oxygenase 1	Mus musculus	198-202
24120440-5	2013	Furthermore, the protection of SFN was also related to decreased levels of oxidative stress in the brains of mice by enhanced activation of the Nrf2/ARE pathway and increased levels of anti-oxidant HO-1 and NQO1 expression.	sulforaphane	31-34	NAD(P)H dehydrogenase, quinone 1	Mus musculus	207-211
24231100-1	2013	The Brassica-derived isothiocyanate sulforaphane (SFN) is known to induce factor erythroid 2-related factor 2 (Nrf2), a transcription factor centrally involved in chemoprevention.	sulforaphane	50-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
24017972-0	2013	Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	36-40
24017972-0	2013	Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	41-45
24017972-2	2013	The brain protects itself against infarction via activation of endogenous antioxidant defense mechanisms, and we here report the first evidence that sulforaphane-mediated preactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1) in the cerebral vasculature protects the brain against stroke.	sulforaphane	149-161	NFE2 like bZIP transcription factor 2	Rattus norvegicus	188-231
24017972-2	2013	The brain protects itself against infarction via activation of endogenous antioxidant defense mechanisms, and we here report the first evidence that sulforaphane-mediated preactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1) in the cerebral vasculature protects the brain against stroke.	sulforaphane	149-161	NFE2 like bZIP transcription factor 2	Rattus norvegicus	233-237
24017972-2	2013	The brain protects itself against infarction via activation of endogenous antioxidant defense mechanisms, and we here report the first evidence that sulforaphane-mediated preactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1) in the cerebral vasculature protects the brain against stroke.	sulforaphane	149-161	heme oxygenase 1	Rattus norvegicus	265-281
24017972-2	2013	The brain protects itself against infarction via activation of endogenous antioxidant defense mechanisms, and we here report the first evidence that sulforaphane-mediated preactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target heme oxygenase-1 (HO-1) in the cerebral vasculature protects the brain against stroke.	sulforaphane	149-161	heme oxygenase 1	Rattus norvegicus	283-287
24017972-5	2013	In naive rats, treatment with sulforaphane increased Nrf2 expression in cerebral microvessels after 24h.	sulforaphane	30-42	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-57
24017972-6	2013	Upregulation of Nrf2 by sulforaphane treatment prior to transient MCAo (1h) was associated with increased HO-1 expression in perivascular astrocytes in peri-infarct regions and cerebral endothelium in the infarct core.	sulforaphane	24-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	16-20
24017972-6	2013	Upregulation of Nrf2 by sulforaphane treatment prior to transient MCAo (1h) was associated with increased HO-1 expression in perivascular astrocytes in peri-infarct regions and cerebral endothelium in the infarct core.	sulforaphane	24-36	heme oxygenase 1	Rattus norvegicus	106-110
23954472-7	2013	Pretreatment with sulforaphane and curcumin also inhibited the OC differentiation by activating Nrf2 in part.	sulforaphane	18-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
24231100-13	2013	mRNA analysis of distal colon samples confirmed reduced expression of inflammatory markers and increased expression of Nrf2-dependent genes in SFN pre-treated mice.	sulforaphane	143-146	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-103
24121007-0	2013	Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: role of Nrf2-dependent gene expression and antioxidant enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	105-109
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	0-12	glutathione S-transferase kappa 1	Homo sapiens	115-140
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	0-12	glutathione S-transferase kappa 1	Homo sapiens	142-145
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	232-237
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	14-17	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-103
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	14-17	NAD(P)H quinone dehydrogenase 1	Homo sapiens	105-109
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	14-17	glutathione S-transferase kappa 1	Homo sapiens	115-140
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	14-17	glutathione S-transferase kappa 1	Homo sapiens	142-145
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	14-17	kelch like ECH associated protein 1	Homo sapiens	232-237
23843041-1	2013	Sulforaphane (SFN) is a potent inducer of detoxication enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase (GST) via the Kelch-like erythroid-derived protein with CNC homology-associated protein 1 (Keap1)-NF-E2-related factor 2 (Nrf2) signaling pathway.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
23715558-9	2013	Treatment with the Nrf2-activator sulforaphane increased Nrf2 and promoted its nuclear localization and increased GCLC and GCLM expression in both db/m and db/db.	sulforaphane	34-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
23836589-7	2013	SFN, BITC, and PEITC pretreatment reversed oxLDL-induced ROS production, NFkappaB nuclear translocation, kappaB-reporter activity, ICAM-1, VCAM-1, and E-selectin expression, and monocyte adhesion to endothelial cells.	sulforaphane	0-3	nuclear factor kappa B subunit 1	Homo sapiens	73-81
23836589-7	2013	SFN, BITC, and PEITC pretreatment reversed oxLDL-induced ROS production, NFkappaB nuclear translocation, kappaB-reporter activity, ICAM-1, VCAM-1, and E-selectin expression, and monocyte adhesion to endothelial cells.	sulforaphane	0-3	intercellular adhesion molecule 1	Homo sapiens	131-137
23836589-7	2013	SFN, BITC, and PEITC pretreatment reversed oxLDL-induced ROS production, NFkappaB nuclear translocation, kappaB-reporter activity, ICAM-1, VCAM-1, and E-selectin expression, and monocyte adhesion to endothelial cells.	sulforaphane	0-3	vascular cell adhesion molecule 1	Homo sapiens	139-145
23836589-7	2013	SFN, BITC, and PEITC pretreatment reversed oxLDL-induced ROS production, NFkappaB nuclear translocation, kappaB-reporter activity, ICAM-1, VCAM-1, and E-selectin expression, and monocyte adhesion to endothelial cells.	sulforaphane	0-3	selectin E	Homo sapiens	151-161
24147970-3	2013	The crucifer-derived bioactive phytochemical sulforaphane is a significant inducer of nuclear factor erythroid 2-related factor 2 (Nrf2), the transcription factor that activates the cell"s endogenous defenses via a battery of cytoprotective genes.	sulforaphane	45-57	NFE2 like bZIP transcription factor 2	Homo sapiens	86-129
24147970-3	2013	The crucifer-derived bioactive phytochemical sulforaphane is a significant inducer of nuclear factor erythroid 2-related factor 2 (Nrf2), the transcription factor that activates the cell"s endogenous defenses via a battery of cytoprotective genes.	sulforaphane	45-57	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
23896025-3	2013	Modulation of Nrf2 through siRNA resulted in a more robust differentiation of C2C12s, whereas increasing Nrf2 with sulforaphane treatment inhibited differentiation.	sulforaphane	115-127	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
23896025-9	2013	Similarly, PGC-1alpha protein levels are correlated with Nrf2 levels in C2C12s after modulation by Nrf2 siRNA or sulforaphane treatment.	sulforaphane	113-125	PPARG coactivator 1 alpha	Homo sapiens	11-21
23896025-9	2013	Similarly, PGC-1alpha protein levels are correlated with Nrf2 levels in C2C12s after modulation by Nrf2 siRNA or sulforaphane treatment.	sulforaphane	113-125	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
24056254-10	2013	Very interestingly, Sulforaphane, Withaferin A, Celastrol and EGCG all decreased the complemented NRL-Hsp90alpha/Cdc37-CRL activities in the concentration-dependent manner.	sulforaphane	20-32	heat shock protein 90 alpha family class A member 1	Homo sapiens	102-112
24056254-10	2013	Very interestingly, Sulforaphane, Withaferin A, Celastrol and EGCG all decreased the complemented NRL-Hsp90alpha/Cdc37-CRL activities in the concentration-dependent manner.	sulforaphane	20-32	cell division cycle 37, HSP90 cochaperone	Homo sapiens	113-118
24056254-10	2013	Very interestingly, Sulforaphane, Withaferin A, Celastrol and EGCG all decreased the complemented NRL-Hsp90alpha/Cdc37-CRL activities in the concentration-dependent manner.	sulforaphane	20-32	interleukin 31 receptor A	Homo sapiens	119-122
23958496-8	2013	CNIs also activated an Nrf2/HO-1-dependent compensatory response and the Nrf2 activator sulforaphane inhibited JAK2 and JNK activation and inflammation.	sulforaphane	88-100	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
23958496-8	2013	CNIs also activated an Nrf2/HO-1-dependent compensatory response and the Nrf2 activator sulforaphane inhibited JAK2 and JNK activation and inflammation.	sulforaphane	88-100	Janus kinase 2	Homo sapiens	111-115
23958496-8	2013	CNIs also activated an Nrf2/HO-1-dependent compensatory response and the Nrf2 activator sulforaphane inhibited JAK2 and JNK activation and inflammation.	sulforaphane	88-100	mitogen-activated protein kinase 8	Homo sapiens	120-123
24030461-4	2013	In this study, we used sulforaphane (SFN) and D3T to investigate a strategy of targeting Nrf2-ARE in FECD.	sulforaphane	23-35	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
24030461-4	2013	In this study, we used sulforaphane (SFN) and D3T to investigate a strategy of targeting Nrf2-ARE in FECD.	sulforaphane	37-40	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
24030461-11	2013	SFN enhanced nuclear translocation of Nrf2 in FECD specimens and decreased p53 staining under oxidative stress.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
24030461-11	2013	SFN enhanced nuclear translocation of Nrf2 in FECD specimens and decreased p53 staining under oxidative stress.	sulforaphane	0-3	collagen type VIII alpha 2 chain	Homo sapiens	46-50
24030461-11	2013	SFN enhanced nuclear translocation of Nrf2 in FECD specimens and decreased p53 staining under oxidative stress.	sulforaphane	0-3	tumor protein p53	Homo sapiens	75-78
24030461-14	2013	SFN significantly upregulated major ARE-dependent antioxidants and ameliorated oxidative stress-induced apoptosis in FECD.	sulforaphane	0-3	collagen type VIII alpha 2 chain	Homo sapiens	117-121
23715558-9	2013	Treatment with the Nrf2-activator sulforaphane increased Nrf2 and promoted its nuclear localization and increased GCLC and GCLM expression in both db/m and db/db.	sulforaphane	34-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
23715558-9	2013	Treatment with the Nrf2-activator sulforaphane increased Nrf2 and promoted its nuclear localization and increased GCLC and GCLM expression in both db/m and db/db.	sulforaphane	34-46	glutamate-cysteine ligase, catalytic subunit	Mus musculus	114-118
23715558-9	2013	Treatment with the Nrf2-activator sulforaphane increased Nrf2 and promoted its nuclear localization and increased GCLC and GCLM expression in both db/m and db/db.	sulforaphane	34-46	glutamate-cysteine ligase, modifier subunit	Mus musculus	123-127
23715558-11	2013	CONCLUSION: Depleted Nrf2 and expression of its dependent genes compromises antioxidant capacity resulting in dysfunctional myogenic tone in diabetes that is reversed by the Nrf2-activator sulforaphane.	sulforaphane	189-201	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
23715558-11	2013	CONCLUSION: Depleted Nrf2 and expression of its dependent genes compromises antioxidant capacity resulting in dysfunctional myogenic tone in diabetes that is reversed by the Nrf2-activator sulforaphane.	sulforaphane	189-201	nuclear factor, erythroid derived 2, like 2	Mus musculus	174-178
23623252-4	2013	Furthermore, treatment of Nrf2 knockout mice with the anti-inflammatory drug rofecoxib reversed their depressive-like behavior, while induction of Nrf2 by sulforaphane, in an inflammatory model of depression elicited by LPS, afforded antidepressant-like effects.	sulforaphane	155-167	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151
23902242-5	2013	A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-kappaB, SHH, epithelial-mesenchymal transition and Wnt/beta-catenin pathways.	sulforaphane	40-52	nuclear factor kappa B subunit 1	Homo sapiens	120-129
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	9-21	kelch-like ECH-associated protein 1	Mus musculus	173-178
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	9-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	179-183
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	9-21	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	240-244
23825090-4	2013	METHODS: Sulforaphane [SF, 1-isothiocyano-4-(methylsulfinyl)butane] derived from its glucosinolate precursor contained in cruciferous vegetables and related inducers of the Keap1/Nrf2/ARE pathway were assessed for their potencies to induce ALDH in murine hepatoma Hepa1c1c7 cells.	sulforaphane	23-25	kelch-like ECH-associated protein 1	Mus musculus	173-178
23825090-9	2013	In mice, in vivo, feeding of SF induced tissue ALDH and dramatically increased (doubled) the rate of elimination of acetaldehyde arising from the administration of ethanol.	sulforaphane	29-31	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	47-51
23756573-0	2013	Sulforaphane enhances the activity of the Nrf2-ARE pathway and attenuates inflammation in OxyHb-induced rat vascular smooth muscle cells.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
23756573-6	2013	SUL enhanced the activity of the Nrf2-ARE pathway and suppressed cytokine release.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	33-37
23748533-5	2013	In contrast, upregulating Nrf2 activity, either by plasmid-mediated overexpression or treatment with the Nrf2 activator sulforaphane, increased the expression of ARE-dependent antioxidants, including NAD(P)H dehydrogenase, quinone 1 and glutathione, improved the expression of tight junction proteins, and restored the ability to form tight barriers in alveolar epithelial cells from HIV-1 transgenic rats.	sulforaphane	120-132	NFE2 like bZIP transcription factor 2	Rattus norvegicus	26-30
23748533-5	2013	In contrast, upregulating Nrf2 activity, either by plasmid-mediated overexpression or treatment with the Nrf2 activator sulforaphane, increased the expression of ARE-dependent antioxidants, including NAD(P)H dehydrogenase, quinone 1 and glutathione, improved the expression of tight junction proteins, and restored the ability to form tight barriers in alveolar epithelial cells from HIV-1 transgenic rats.	sulforaphane	120-132	NFE2 like bZIP transcription factor 2	Rattus norvegicus	105-109
23748533-7	2013	Furthermore, this study suggests that activating the Nrf2/ARE pathway with the dietary supplement sulforaphane could augment antioxidant defenses and lung health in HIV-1-infected individuals.	sulforaphane	98-110	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-57
24030395-6	2013	SF-PreCon significantly decreased MI/R-induced superoxide generation in wild-type (-43.6%) and AMPK dominant-negative overexpressing mice (-35.5%; P<0.01) but not in Cav-3 knockout mice.	sulforaphane	0-2	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	95-99
24030395-6	2013	SF-PreCon significantly decreased MI/R-induced superoxide generation in wild-type (-43.6%) and AMPK dominant-negative overexpressing mice (-35.5%; P<0.01) but not in Cav-3 knockout mice.	sulforaphane	0-2	caveolin 3	Mus musculus	169-174
24030395-8	2013	CONCLUSIONS: We demonstrate for the first time SF-PreCon mediates cardioprotection against MI/R injury via caveolin-3-dependent cyclooxygenase-2 inhibition and antioxidative effects.	sulforaphane	47-49	caveolin 3	Mus musculus	107-117
24030395-8	2013	CONCLUSIONS: We demonstrate for the first time SF-PreCon mediates cardioprotection against MI/R injury via caveolin-3-dependent cyclooxygenase-2 inhibition and antioxidative effects.	sulforaphane	47-49	prostaglandin-endoperoxide synthase 2	Mus musculus	128-144
23876469-10	2013	Treatment of rats with sulforaphane alone induced modest activation of Nrf2 and phase II antioxidant enzymes, although having no effect on BP, redox status, or D1R function.	sulforaphane	23-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
23876469-12	2013	In these animals, sulforaphane, whereas attenuating nuclear factor-kappaB activation, caused a robust stimulation of Nrf2 and phase II antioxidant enzyme pathway.	sulforaphane	18-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-121
23876469-14	2013	Sulforaphane via activation of Nrf2-phase II antioxidant enzyme pathway mitigated oxidative stress and nuclear factor-kappaB activation, preserved D1R function, and prevented hypertension.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	31-35
23812493-16	2013	Nrf2 translocated to the nucleus in response to 0.5- to 2.0-muM SFN exposure CONCLUSIONS: The dietary component SFN demonstrates an ability to protect human lens cells against oxidative stress and thus could potentially delay the onset of cataract.	sulforaphane	64-67	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
23812493-16	2013	Nrf2 translocated to the nucleus in response to 0.5- to 2.0-muM SFN exposure CONCLUSIONS: The dietary component SFN demonstrates an ability to protect human lens cells against oxidative stress and thus could potentially delay the onset of cataract.	sulforaphane	112-115	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
23797263-0	2013	Chronic sulforaphane oral treatment accentuates blood glucose impairment and may affect GLUT3 expression in the cerebral cortex and hypothalamus of rats fed with a highly palatable diet.	sulforaphane	8-20	solute carrier family 2 member 3	Rattus norvegicus	88-93
23797263-8	2013	Although expression of GLUT1 was similar between groups for all three brain structures analyzed, expression of GLUT3 in the cortex and hypothalamus had a tendency to decrease in the HP diet group treated with SFN.	sulforaphane	209-212	solute carrier family 2 member 3	Rattus norvegicus	111-116
23797263-9	2013	In conclusion, SFN at the specific dose was able to accentuate glucose intolerance and may affect GLUT3 expression in the cerebral cortex and hypothalamus.	sulforaphane	15-18	solute carrier family 2 member 3	Rattus norvegicus	98-103
23902242-5	2013	A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-kappaB, SHH, epithelial-mesenchymal transition and Wnt/beta-catenin pathways.	sulforaphane	40-52	sonic hedgehog signaling molecule	Homo sapiens	131-134
23902242-5	2013	A number of studies have indicated that sulforaphane may target CSCs in different types of cancer through modulation of NF-kappaB, SHH, epithelial-mesenchymal transition and Wnt/beta-catenin pathways.	sulforaphane	40-52	catenin beta 1	Homo sapiens	178-190
23690560-7	2013	Pretreatment with the Nrf2 inducer sulforaphane reduced total cellular Nrf2 levels in peri-infarct and core regions of the stroke hemisphere after 24 h reperfusion.	sulforaphane	35-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	22-26
23476038-9	2013	MDM2 blockade with nutlin-3a completely blocked the protective effects of sulforaphane on renal cell survival, outgrowth and wound closure.	sulforaphane	74-86	transformed mouse 3T3 cell double minute 2	Mus musculus	0-4
23583297-6	2013	In contrast, DIM+SFN or TCDD+SFN induced NQO1 and HMOX1 mRNA expression to levels higher than SFN alone, which was prevented by RNAi-mediated knockdown of AHR.	sulforaphane	17-20	NAD(P)H quinone dehydrogenase 1	Homo sapiens	41-45
23583297-6	2013	In contrast, DIM+SFN or TCDD+SFN induced NQO1 and HMOX1 mRNA expression to levels higher than SFN alone, which was prevented by RNAi-mediated knockdown of AHR.	sulforaphane	17-20	heme oxygenase 1	Homo sapiens	50-55
23583297-6	2013	In contrast, DIM+SFN or TCDD+SFN induced NQO1 and HMOX1 mRNA expression to levels higher than SFN alone, which was prevented by RNAi-mediated knockdown of AHR.	sulforaphane	17-20	aryl hydrocarbon receptor	Homo sapiens	155-158
23583297-6	2013	In contrast, DIM+SFN or TCDD+SFN induced NQO1 and HMOX1 mRNA expression to levels higher than SFN alone, which was prevented by RNAi-mediated knockdown of AHR.	sulforaphane	29-32	NAD(P)H quinone dehydrogenase 1	Homo sapiens	41-45
23583297-6	2013	In contrast, DIM+SFN or TCDD+SFN induced NQO1 and HMOX1 mRNA expression to levels higher than SFN alone, which was prevented by RNAi-mediated knockdown of AHR.	sulforaphane	29-32	heme oxygenase 1	Homo sapiens	50-55
23583297-6	2013	In contrast, DIM+SFN or TCDD+SFN induced NQO1 and HMOX1 mRNA expression to levels higher than SFN alone, which was prevented by RNAi-mediated knockdown of AHR.	sulforaphane	29-32	aryl hydrocarbon receptor	Homo sapiens	155-158
23583297-3	2013	In this study we investigated the crosstalk among NRF2, AHR and ERalpha in MCF-7 breast cancer cells treated with the NRF2 activator sulforaphane (SFN), a dual AHR and ERalpha activator, 3,3"-diindolylmethane (DIM), 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 17beta-estradiol (E2).	sulforaphane	133-145	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
23690560-7	2013	Pretreatment with the Nrf2 inducer sulforaphane reduced total cellular Nrf2 levels in peri-infarct and core regions of the stroke hemisphere after 24 h reperfusion.	sulforaphane	35-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75
23690560-8	2013	Treatment of cultured murine brain endothelial cells with sulforaphane (2.5 mum) increased nuclear accumulation of Nrf2 over 1-4 h. We report the first quantitative measurements of spatial and temporal nuclear Nrf2 expression in rat brains following stroke, and show that sulforaphane pretreatment affects Nrf2 distribution in the brain of naive rats and animals subjected to cerebral ischaemia.	sulforaphane	58-70	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
23690560-8	2013	Treatment of cultured murine brain endothelial cells with sulforaphane (2.5 mum) increased nuclear accumulation of Nrf2 over 1-4 h. We report the first quantitative measurements of spatial and temporal nuclear Nrf2 expression in rat brains following stroke, and show that sulforaphane pretreatment affects Nrf2 distribution in the brain of naive rats and animals subjected to cerebral ischaemia.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	210-214
23690560-8	2013	Treatment of cultured murine brain endothelial cells with sulforaphane (2.5 mum) increased nuclear accumulation of Nrf2 over 1-4 h. We report the first quantitative measurements of spatial and temporal nuclear Nrf2 expression in rat brains following stroke, and show that sulforaphane pretreatment affects Nrf2 distribution in the brain of naive rats and animals subjected to cerebral ischaemia.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	210-214
23690560-8	2013	Treatment of cultured murine brain endothelial cells with sulforaphane (2.5 mum) increased nuclear accumulation of Nrf2 over 1-4 h. We report the first quantitative measurements of spatial and temporal nuclear Nrf2 expression in rat brains following stroke, and show that sulforaphane pretreatment affects Nrf2 distribution in the brain of naive rats and animals subjected to cerebral ischaemia.	sulforaphane	272-284	NFE2 like bZIP transcription factor 2	Rattus norvegicus	210-214
23690560-8	2013	Treatment of cultured murine brain endothelial cells with sulforaphane (2.5 mum) increased nuclear accumulation of Nrf2 over 1-4 h. We report the first quantitative measurements of spatial and temporal nuclear Nrf2 expression in rat brains following stroke, and show that sulforaphane pretreatment affects Nrf2 distribution in the brain of naive rats and animals subjected to cerebral ischaemia.	sulforaphane	272-284	NFE2 like bZIP transcription factor 2	Rattus norvegicus	210-214
23657153-7	2013	Combination of SFN with (-)-epigallocatechin gallate as a demethylating agent is identified as an effective approach for re-expression of estrogen receptor in hormone negative breast cancer.	sulforaphane	15-18	estrogen receptor 1	Homo sapiens	138-155
23417518-0	2013	Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane.	sulforaphane	101-113	mitogen-activated protein kinase kinase 7	Homo sapiens	79-82
23417518-0	2013	Growth inhibition and apoptosis of neuroblastoma cells through ROS-independent MEK/ERK activation by sulforaphane.	sulforaphane	101-113	mitogen-activated protein kinase 1	Homo sapiens	83-86
23417518-5	2013	We found that treating SH-SY5Y cells with SFN resulted in the depletion of mitochondrial membrane potential (Deltapsi), which in turn increased caspase 9, caspase 3, and the up-regulation of phosphorylated MEK/ERK without generating reactive oxygen species.	sulforaphane	42-45	caspase 9	Homo sapiens	144-153
23417518-5	2013	We found that treating SH-SY5Y cells with SFN resulted in the depletion of mitochondrial membrane potential (Deltapsi), which in turn increased caspase 9, caspase 3, and the up-regulation of phosphorylated MEK/ERK without generating reactive oxygen species.	sulforaphane	42-45	caspase 3	Homo sapiens	155-164
23417518-5	2013	We found that treating SH-SY5Y cells with SFN resulted in the depletion of mitochondrial membrane potential (Deltapsi), which in turn increased caspase 9, caspase 3, and the up-regulation of phosphorylated MEK/ERK without generating reactive oxygen species.	sulforaphane	42-45	mitogen-activated protein kinase kinase 7	Homo sapiens	206-209
23417518-5	2013	We found that treating SH-SY5Y cells with SFN resulted in the depletion of mitochondrial membrane potential (Deltapsi), which in turn increased caspase 9, caspase 3, and the up-regulation of phosphorylated MEK/ERK without generating reactive oxygen species.	sulforaphane	42-45	mitogen-activated protein kinase 1	Homo sapiens	210-213
23657153-8	2013	Induction of miR-200c by SFN prevents epithelial-mesenchymal-transition and could be relevant for prevention of metastases.	sulforaphane	25-28	microRNA 200c	Homo sapiens	13-21
24024172-3	2013	In this study we show that activation of Nrf2, either by the small molecule sulforaphane or knockout of the Nrf2 inhibitor Keap1, leads to increased cellular glucose uptake and increased glucose addiction in fibroblasts.	sulforaphane	76-88	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
23810908-0	2013	Sulforaphane inhibits PDGF-induced proliferation of rat aortic vascular smooth muscle cell by up-regulation of p53 leading to G1/S cell cycle arrest.	sulforaphane	0-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	111-114
23810908-5	2013	Sulforaphane increased the cyclin-dependent kinase inhibitor p21 and p53 levels, while it decreased CDK2 and cyclin E expression.	sulforaphane	0-12	KRAS proto-oncogene, GTPase	Rattus norvegicus	61-64
23810908-5	2013	Sulforaphane increased the cyclin-dependent kinase inhibitor p21 and p53 levels, while it decreased CDK2 and cyclin E expression.	sulforaphane	0-12	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	69-72
23810908-5	2013	Sulforaphane increased the cyclin-dependent kinase inhibitor p21 and p53 levels, while it decreased CDK2 and cyclin E expression.	sulforaphane	0-12	cyclin dependent kinase 2	Rattus norvegicus	100-104
23810908-5	2013	Sulforaphane increased the cyclin-dependent kinase inhibitor p21 and p53 levels, while it decreased CDK2 and cyclin E expression.	sulforaphane	0-12	cyclin E1	Rattus norvegicus	109-117
23810908-9	2013	These results suggest that sulforaphane-inhibited VSMC proliferation may occur through the G1/S cell cycle arrest by up-regulation of p53 signaling pathway, and then lead to the decreased neointimal hyperplasia thickening.	sulforaphane	27-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	134-137
23799914-0	2013	Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.	sulforaphane	0-12	cyclin B1	Homo sapiens	77-86
23799914-0	2013	Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.	sulforaphane	0-12	cyclin dependent kinase 1	Homo sapiens	87-91
23799914-7	2013	SFN-treated cells accumulated in metaphase by CDC2 down-regulation and dissociation of the cyclin B1/CDC2 complex.	sulforaphane	0-3	cyclin dependent kinase 1	Homo sapiens	46-50
23799914-7	2013	SFN-treated cells accumulated in metaphase by CDC2 down-regulation and dissociation of the cyclin B1/CDC2 complex.	sulforaphane	0-3	cyclin B1	Homo sapiens	91-100
23799914-7	2013	SFN-treated cells accumulated in metaphase by CDC2 down-regulation and dissociation of the cyclin B1/CDC2 complex.	sulforaphane	0-3	cyclin dependent kinase 1	Homo sapiens	101-105
23566952-0	2013	Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro.	sulforaphane	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	22-28
23566952-3	2013	In this study, we studied the effects of SFN on CYP1A1 activity and genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).	sulforaphane	41-44	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	48-54
23566952-4	2013	The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking.	sulforaphane	24-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	51-57
23566952-4	2013	The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking.	sulforaphane	24-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	105-111
23566952-4	2013	The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking.	sulforaphane	24-27	aryl hydrocarbon receptor	Rattus norvegicus	150-175
23566952-4	2013	The results showed that SFN inhibited TCDD-induced CYP1A1 activity in H4IIE cells by directly inhibiting CYP1A1 activity, probably through binding to aryl hydrocarbon receptor and/or CYP1A1 revealed by molecular docking.	sulforaphane	24-27	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	105-111
23770684-0	2013	HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.	sulforaphane	105-117	RB binding protein 8, endonuclease	Homo sapiens	15-19
23159064-0	2013	Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells.	sulforaphane	53-65	microRNA 200c	Homo sapiens	100-108
23159064-0	2013	Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells.	sulforaphane	53-65	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-75
23159064-0	2013	Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells.	sulforaphane	53-65	zinc finger E-box binding homeobox 1	Homo sapiens	109-113
23159064-0	2013	Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells.	sulforaphane	53-65	matrix metallopeptidase 2	Homo sapiens	76-83
23159064-4	2013	Transfection with cyclooxygenase-2 (COX-2) overexpression plasmid largely abolished inhibition of MMP2/9 expression as well as cell invasive capability by sulforaphane.	sulforaphane	155-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34
23159064-0	2013	Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells.	sulforaphane	53-65	snail family transcriptional repressor 1	Homo sapiens	84-89
23246160-9	2013	Sulforaphane inhibited platelet activation accompanied by inhibiting relative Ca(2+) mobilization; phosphorylation of phospholipase C (PLC)gamma2, protein kinase C (PKC), mitogen-activated protein kinases (MAPKs) and Akt; and hydroxyl radical (OH( )) formation.	sulforaphane	0-12	phospholipase C, gamma 2	Mus musculus	135-145
23159064-4	2013	Transfection with cyclooxygenase-2 (COX-2) overexpression plasmid largely abolished inhibition of MMP2/9 expression as well as cell invasive capability by sulforaphane.	sulforaphane	155-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
23246160-9	2013	Sulforaphane inhibited platelet activation accompanied by inhibiting relative Ca(2+) mobilization; phosphorylation of phospholipase C (PLC)gamma2, protein kinase C (PKC), mitogen-activated protein kinases (MAPKs) and Akt; and hydroxyl radical (OH( )) formation.	sulforaphane	0-12	thymoma viral proto-oncogene 1	Mus musculus	217-220
23159064-0	2013	Epithelial-mesenchymal transition, a novel target of sulforaphane via COX-2/MMP2, 9/Snail, ZEB1 and miR-200c/ZEB1 pathways in human bladder cancer cells.	sulforaphane	53-65	zinc finger E-box binding homeobox 1	Homo sapiens	91-95
23159064-5	2013	Moreover, sulforaphane inhibited the epithelial-to-mesenchymal transition (EMT) process which underlies tumor cell invasion and migration mediated by E-cadherin induction through reducing transcriptional repressors, such as ZEB1 and Snail.	sulforaphane	10-22	cadherin 1	Homo sapiens	150-160
23246160-13	2013	This study demonstrates for the first time that in addition to it originally being considered as an agent for prevention of tumor growth, sulforaphane possesses potent antiplatelet activity which may initially activate adenylate cyclase/cAMP, followed by inhibiting intracellular signals (such as the PI3-kinase/Akt and PLCgamma2-PKC-p47 cascades) and ultimately inhibiting platelet activation.	sulforaphane	138-150	thymoma viral proto-oncogene 1	Mus musculus	312-315
23246160-10	2013	Sulforaphane markedly increased cyclic (c)AMP, but not cyclic (c)GMP levels, and stimulated vasodilator-stimulated phosphoprotein (VASP) phosphorylation.	sulforaphane	0-12	5'-nucleotidase, cytosolic II	Mus musculus	65-68
23159064-5	2013	Moreover, sulforaphane inhibited the epithelial-to-mesenchymal transition (EMT) process which underlies tumor cell invasion and migration mediated by E-cadherin induction through reducing transcriptional repressors, such as ZEB1 and Snail.	sulforaphane	10-22	zinc finger E-box binding homeobox 1	Homo sapiens	224-228
23246160-10	2013	Sulforaphane markedly increased cyclic (c)AMP, but not cyclic (c)GMP levels, and stimulated vasodilator-stimulated phosphoprotein (VASP) phosphorylation.	sulforaphane	0-12	vasodilator-stimulated phosphoprotein	Mus musculus	92-129
23159064-5	2013	Moreover, sulforaphane inhibited the epithelial-to-mesenchymal transition (EMT) process which underlies tumor cell invasion and migration mediated by E-cadherin induction through reducing transcriptional repressors, such as ZEB1 and Snail.	sulforaphane	10-22	snail family transcriptional repressor 1	Homo sapiens	233-238
23246160-10	2013	Sulforaphane markedly increased cyclic (c)AMP, but not cyclic (c)GMP levels, and stimulated vasodilator-stimulated phosphoprotein (VASP) phosphorylation.	sulforaphane	0-12	vasodilator-stimulated phosphoprotein	Mus musculus	131-135
23159064-6	2013	Under conditions of over-expression of COX-2 and/or MMP2/9, sulforaphane was still able to induce E-cadherin or reduce Snail/ZEB1 expression, suggesting that additional pathways might be involved.	sulforaphane	60-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	39-44
23159064-6	2013	Under conditions of over-expression of COX-2 and/or MMP2/9, sulforaphane was still able to induce E-cadherin or reduce Snail/ZEB1 expression, suggesting that additional pathways might be involved.	sulforaphane	60-72	matrix metallopeptidase 2	Homo sapiens	52-58
23159064-6	2013	Under conditions of over-expression of COX-2 and/or MMP2/9, sulforaphane was still able to induce E-cadherin or reduce Snail/ZEB1 expression, suggesting that additional pathways might be involved.	sulforaphane	60-72	cadherin 1	Homo sapiens	98-108
23159064-6	2013	Under conditions of over-expression of COX-2 and/or MMP2/9, sulforaphane was still able to induce E-cadherin or reduce Snail/ZEB1 expression, suggesting that additional pathways might be involved.	sulforaphane	60-72	snail family transcriptional repressor 1	Homo sapiens	119-124
23159064-6	2013	Under conditions of over-expression of COX-2 and/or MMP2/9, sulforaphane was still able to induce E-cadherin or reduce Snail/ZEB1 expression, suggesting that additional pathways might be involved.	sulforaphane	60-72	zinc finger E-box binding homeobox 1	Homo sapiens	125-129
23159064-8	2013	In conclusion, the EMT and two recognized signaling pathways (COX-2/MMP2,9/ ZEB1, Snail and miR-200c/ZEB1) are all targets for sulforaphane.	sulforaphane	127-139	prostaglandin-endoperoxide synthase 2	Homo sapiens	62-67
23159064-8	2013	In conclusion, the EMT and two recognized signaling pathways (COX-2/MMP2,9/ ZEB1, Snail and miR-200c/ZEB1) are all targets for sulforaphane.	sulforaphane	127-139	matrix metallopeptidase 2	Homo sapiens	68-74
23159064-8	2013	In conclusion, the EMT and two recognized signaling pathways (COX-2/MMP2,9/ ZEB1, Snail and miR-200c/ZEB1) are all targets for sulforaphane.	sulforaphane	127-139	zinc finger E-box binding homeobox 1	Homo sapiens	76-80
23159064-8	2013	In conclusion, the EMT and two recognized signaling pathways (COX-2/MMP2,9/ ZEB1, Snail and miR-200c/ZEB1) are all targets for sulforaphane.	sulforaphane	127-139	snail family transcriptional repressor 1	Homo sapiens	82-87
23159064-8	2013	In conclusion, the EMT and two recognized signaling pathways (COX-2/MMP2,9/ ZEB1, Snail and miR-200c/ZEB1) are all targets for sulforaphane.	sulforaphane	127-139	microRNA 200c	Homo sapiens	92-100
23159064-8	2013	In conclusion, the EMT and two recognized signaling pathways (COX-2/MMP2,9/ ZEB1, Snail and miR-200c/ZEB1) are all targets for sulforaphane.	sulforaphane	127-139	zinc finger E-box binding homeobox 1	Homo sapiens	101-105
23589329-7	2013	In contrast, activation of Nrf2 by sulforaphane (SF) and tert-butylhydroquinone (tBHQ) depends upon Keap1-C151 and not p62 (the canonical mechanism).	sulforaphane	35-47	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
23589329-7	2013	In contrast, activation of Nrf2 by sulforaphane (SF) and tert-butylhydroquinone (tBHQ) depends upon Keap1-C151 and not p62 (the canonical mechanism).	sulforaphane	35-47	kelch like ECH associated protein 1	Homo sapiens	100-105
23589329-7	2013	In contrast, activation of Nrf2 by sulforaphane (SF) and tert-butylhydroquinone (tBHQ) depends upon Keap1-C151 and not p62 (the canonical mechanism).	sulforaphane	49-51	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
23589329-7	2013	In contrast, activation of Nrf2 by sulforaphane (SF) and tert-butylhydroquinone (tBHQ) depends upon Keap1-C151 and not p62 (the canonical mechanism).	sulforaphane	49-51	kelch like ECH associated protein 1	Homo sapiens	100-105
23486012-11	2013	Phenotypically normal mice heterozygous for the Aqp11 mutation repeatedly treated with glucose showed increased blood urea nitrogen levels that were prevented by the antioxidant sulforaphane or by phlorizin.	sulforaphane	178-190	aquaporin 11	Mus musculus	48-53
23426129-0	2013	Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway.	sulforaphane	0-12	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	72-101
23426129-0	2013	Sulforaphane prevents human platelet aggregation through inhibiting the phosphatidylinositol 3-kinase/Akt pathway.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	102-105
23426129-3	2013	In the present study, we show that sulforaphane inhibited human platelet aggregation caused by different receptor agonists, including collagen, U46619 (a thromboxane A2 mimic), protease-activated receptor 1 agonist peptide (PAR1-AP), and an ADP P2Y12 receptor agonist.	sulforaphane	35-47	coagulation factor II thrombin receptor	Homo sapiens	177-206
23426129-5	2013	In exploring the underlying mechanism, we found that sulforaphane specifically prevented phosphatidylinositol 3-kinase (PI3K)/Akt signalling, without markedly affecting other signlaling pathways involved in platelet aggregation, such as protein kinase C activation, calcium mobilisation, and protein tyrosine phosphorylation.	sulforaphane	53-65	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	89-118
23426129-5	2013	In exploring the underlying mechanism, we found that sulforaphane specifically prevented phosphatidylinositol 3-kinase (PI3K)/Akt signalling, without markedly affecting other signlaling pathways involved in platelet aggregation, such as protein kinase C activation, calcium mobilisation, and protein tyrosine phosphorylation.	sulforaphane	53-65	AKT serine/threonine kinase 1	Homo sapiens	126-129
23426129-7	2013	In addition, sulforaphane caused ubiquitination and degradation of phosphoinositide-dependent kinase 1 (PDK1), which is required for Akt activation.	sulforaphane	13-25	pyruvate dehydrogenase kinase 1	Homo sapiens	67-102
23426129-7	2013	In addition, sulforaphane caused ubiquitination and degradation of phosphoinositide-dependent kinase 1 (PDK1), which is required for Akt activation.	sulforaphane	13-25	pyruvate dehydrogenase kinase 1	Homo sapiens	104-108
23426129-7	2013	In addition, sulforaphane caused ubiquitination and degradation of phosphoinositide-dependent kinase 1 (PDK1), which is required for Akt activation.	sulforaphane	13-25	AKT serine/threonine kinase 1	Homo sapiens	133-136
23426129-8	2013	Therefore, sulforaphane is able to inhibit the PI3K/Akt pathway at two distinct sites.	sulforaphane	11-23	AKT serine/threonine kinase 1	Homo sapiens	52-55
23426129-9	2013	In conclusion, we have demonstrated that sulforaphane prevented platelet aggregation and reduced thrombus formation in flow conditions; our data also support that the inhibition of the PI3K/Akt pathway by sulforaphane contributes it antiplatelet effects.	sulforaphane	41-53	AKT serine/threonine kinase 1	Homo sapiens	190-193
23426129-9	2013	In conclusion, we have demonstrated that sulforaphane prevented platelet aggregation and reduced thrombus formation in flow conditions; our data also support that the inhibition of the PI3K/Akt pathway by sulforaphane contributes it antiplatelet effects.	sulforaphane	205-217	AKT serine/threonine kinase 1	Homo sapiens	190-193
23425096-0	2013	Sulforaphane protects against ethanol-induced oxidative stress and apoptosis in neural crest cells by the induction of Nrf2-mediated antioxidant response.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
23583403-0	2013	Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.	sulforaphane	0-12	toll like receptor 4	Homo sapiens	49-53
23583403-0	2013	Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.	sulforaphane	0-12	lymphocyte antigen 96	Homo sapiens	54-57
23583403-0	2013	Sulforaphane inhibits the engagement of LPS with TLR4/MD2 complex by preferential binding to Cys133 in MD2.	sulforaphane	0-12	lymphocyte antigen 96	Homo sapiens	103-106
23583403-5	2013	In this study, we showed that sulforaphane (SFN) interfered with the binding of LPS to MD2 as determined by in vitro binding assay and co-immunoprecipitation of MD2 and LPS in a cell system.	sulforaphane	30-42	lymphocyte antigen 96	Homo sapiens	87-90
23583403-5	2013	In this study, we showed that sulforaphane (SFN) interfered with the binding of LPS to MD2 as determined by in vitro binding assay and co-immunoprecipitation of MD2 and LPS in a cell system.	sulforaphane	30-42	lymphocyte antigen 96	Homo sapiens	161-164
23583403-5	2013	In this study, we showed that sulforaphane (SFN) interfered with the binding of LPS to MD2 as determined by in vitro binding assay and co-immunoprecipitation of MD2 and LPS in a cell system.	sulforaphane	44-47	lymphocyte antigen 96	Homo sapiens	87-90
23583403-5	2013	In this study, we showed that sulforaphane (SFN) interfered with the binding of LPS to MD2 as determined by in vitro binding assay and co-immunoprecipitation of MD2 and LPS in a cell system.	sulforaphane	44-47	lymphocyte antigen 96	Homo sapiens	161-164
23583403-6	2013	The inhibitory effect of SFN on the interaction of LPS and MD2 was reversed by thiol supplementation with N-acetyl-L-cysteine or dithiothreitol showing that the inhibitory effect of SFN is dependent on its thiol-modifying activity.	sulforaphane	25-28	lymphocyte antigen 96	Homo sapiens	59-62
23583403-6	2013	The inhibitory effect of SFN on the interaction of LPS and MD2 was reversed by thiol supplementation with N-acetyl-L-cysteine or dithiothreitol showing that the inhibitory effect of SFN is dependent on its thiol-modifying activity.	sulforaphane	182-185	lymphocyte antigen 96	Homo sapiens	59-62
23583403-7	2013	Indeed, micro LC-MS/MS analysis showed that SFN preferentially formed adducts with Cys133 in the hydrophobic pocket of MD2, but not with Cys95 and Cys105.	sulforaphane	44-47	lymphocyte antigen 96	Homo sapiens	119-122
23624066-1	2013	Sulforaphane; [1-isothiocyanato-4-(methylsulfinyl) butane], (SFN) is an isothiocyanate derived from glucoraphanin present in cruciferous vegetables and has a variety of potential chemopreventive actions.	sulforaphane	0-12	RNA exonuclease 2	Homo sapiens	61-64
23624066-1	2013	Sulforaphane; [1-isothiocyanato-4-(methylsulfinyl) butane], (SFN) is an isothiocyanate derived from glucoraphanin present in cruciferous vegetables and has a variety of potential chemopreventive actions.	sulforaphane	15-57	RNA exonuclease 2	Homo sapiens	61-64
23416117-0	2013	Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
23416117-0	2013	Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.	sulforaphane	0-12	translocating chain-associating membrane protein 1	Mus musculus	57-62
23509350-2	2013	In this study, we investigated the effects of ITCs on TLR signaling, and found that the two most promising ITCs, phenethyl ITCs (PEITC) and D,L-sulforaphane (SFN), have differential effects on dsRNA-mediated innate immune signaling through TLR3.	sulforaphane	158-161	toll like receptor 3	Homo sapiens	54-57
23518299-6	2013	In addition, SFN protected 6-OHDA-induced apoptosis via blocking DNA fragmentation and caspase-3 activation.	sulforaphane	13-16	caspase 3	Mus musculus	87-96
23509350-2	2013	In this study, we investigated the effects of ITCs on TLR signaling, and found that the two most promising ITCs, phenethyl ITCs (PEITC) and D,L-sulforaphane (SFN), have differential effects on dsRNA-mediated innate immune signaling through TLR3.	sulforaphane	158-161	RNA exonuclease 2	Homo sapiens	140-156
23509350-2	2013	In this study, we investigated the effects of ITCs on TLR signaling, and found that the two most promising ITCs, phenethyl ITCs (PEITC) and D,L-sulforaphane (SFN), have differential effects on dsRNA-mediated innate immune signaling through TLR3.	sulforaphane	158-161	toll like receptor 3	Homo sapiens	240-244
23353773-0	2013	Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation.	sulforaphane	14-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	90-94
23306837-8	2013	In contrast, treating alcohol-exposed alveolar epithelial cells in vitro with the Nrf2 activator, sulforaphane, preserved Nrf2 expression, ARE activation, intracellular GSH levels, and epithelial barrier function.	sulforaphane	98-110	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
23306837-8	2013	In contrast, treating alcohol-exposed alveolar epithelial cells in vitro with the Nrf2 activator, sulforaphane, preserved Nrf2 expression, ARE activation, intracellular GSH levels, and epithelial barrier function.	sulforaphane	98-110	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
23306837-9	2013	These new experimental findings implicate down-regulation of the Nrf2-ARE signaling pathway as a fundamental mechanism by which alcohol causes profound oxidative stress and alveolar epithelial dysfunction, and suggest that treatments, such as sulforaphane, that activate this pathway could mitigate the pathophysiological consequences of alcohol on the lung and other organs.	sulforaphane	243-255	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
23615261-0	2013	Sulforaphane controls TPA-induced MMP-9 expression through the NF-kappaB signaling pathway, but not AP-1, in MCF-7 breast cancer cells.	sulforaphane	0-12	matrix metallopeptidase 9	Homo sapiens	34-39
23615261-4	2013	In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells.	sulforaphane	45-57	matrix metallopeptidase 9	Homo sapiens	113-118
23615261-5	2013	TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane treatment.	sulforaphane	65-77	matrix metallopeptidase 9	Homo sapiens	12-17
23615261-9	2013	In this study, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by sulforaphane was mediated by the suppression of the NF-kappaB pathway in MCF-7 cells.	sulforaphane	104-116	matrix metallopeptidase 9	Homo sapiens	66-71
23275005-0	2013	Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Rattus norvegicus	22-26
23353773-6	2013	SFN significantly prevented diabetes-induced high blood pressure and cardiac dysfunction at both 3 and 6 months, and also prevented diabetes-induced cardiac hypertrophy (increased the ratio of heart weight to tibia length and the expression of atrial natriuretic peptide mRNA and protein) and fibrosis (increased the accumulation of collagen and expression of connective tissue growth factor and tissue growth factor-beta).	sulforaphane	0-3	cellular communication network factor 2	Mus musculus	360-391
23353773-7	2013	SFN also almost completely prevented diabetes-induced cardiac oxidative damage (increased accumulation of 3-nitrotyrosine and 4-hydroxynonenal) and inflammation (increased tumor necrotic factor-alpha and plasminogen activator inhibitor 1 expression).	sulforaphane	0-3	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	178-237
23353773-10	2013	These results suggest that diabetes-induced cardiomyopathy can be prevented by SFN, which was associated with the up-regulated Nrf2 expression and transcription function.	sulforaphane	79-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
23404329-3	2013	Results             demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination             reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by             ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose)             polymerase (PARP) proteins.	sulforaphane	83-86	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	99-102
23404329-3	2013	Results             demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination             reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by             ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose)             polymerase (PARP) proteins.	sulforaphane	83-86	caspase 3	Homo sapiens	267-276
23404329-3	2013	Results             demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination             reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by             ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose)             polymerase (PARP) proteins.	sulforaphane	83-86	poly(ADP-ribose) polymerase 1	Homo sapiens	281-320
23404329-3	2013	Results             demonstrated that low doses of ASP (1 mM), CUR (10 microM) and SFN (5 microM) (ACS) combination             reduced cell viability by ~70% (P<0.001), and also induced cell apoptosis by             ~51% (P<0.001) accompanied by activation of caspase-3 and Poly(ADP-ribose)             polymerase (PARP) proteins.	sulforaphane	83-86	poly(ADP-ribose) polymerase 1	Homo sapiens	322-326
23403058-2	2013	However, little is known regarding the Nrf2-inducing activities of the lower structure-related sulforaphane homologues, such as iberverin, iberin and cheirolin, which exhibit different sulfur oxidation states.	sulforaphane	95-107	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
23403058-6	2013	Overall, iberverin, iberin and cheirolin exhibited a similar potency to sulforaphane in inducing Nrf2-dependent gene-expression.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
23195333-0	2013	Sulforaphane induces SLPI secretion in the nasal mucosa.	sulforaphane	0-12	secretory leukocyte peptidase inhibitor	Homo sapiens	21-25
23305850-6	2013	Firstly, in the normal human renal epithelial HK-2 cells, the measurement of the expression of 30 previously reported NRF2 target genes in response to NRF2 inducers (sulforaphane, tert-butylhydroquinone, cinnamic aldehyde, and hydrogen peroxide) showed that the aldo-keto reductase (AKR) 1C1 is highly inducible by all treatments.	sulforaphane	166-178	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
23305850-6	2013	Firstly, in the normal human renal epithelial HK-2 cells, the measurement of the expression of 30 previously reported NRF2 target genes in response to NRF2 inducers (sulforaphane, tert-butylhydroquinone, cinnamic aldehyde, and hydrogen peroxide) showed that the aldo-keto reductase (AKR) 1C1 is highly inducible by all treatments.	sulforaphane	166-178	NFE2 like bZIP transcription factor 2	Homo sapiens	151-155
23305850-10	2013	The treatment of U937 cells with NRF2 inducers including sulforaphane effectively elevated the expression of AKR1B1, 1B10, 1C1, 1C2, and 1C3.	sulforaphane	57-69	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
23305850-10	2013	The treatment of U937 cells with NRF2 inducers including sulforaphane effectively elevated the expression of AKR1B1, 1B10, 1C1, 1C2, and 1C3.	sulforaphane	57-69	aldo-keto reductase family 1 member B	Homo sapiens	109-115
23305850-11	2013	Whereas, the levels of both the basal and sulforaphane-inducible expression of AKR1C1 were significantly reduced in NRF2-silenced stable U937 cells compared to the control cells.	sulforaphane	42-54	aldo-keto reductase family 1 member C1	Homo sapiens	79-85
23305850-11	2013	Whereas, the levels of both the basal and sulforaphane-inducible expression of AKR1C1 were significantly reduced in NRF2-silenced stable U937 cells compared to the control cells.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
23333498-0	2013	Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation.	sulforaphane	29-41	telomerase reverse transcriptase	Homo sapiens	134-139
23333498-0	2013	Epigallocatechin gallate and sulforaphane combination treatment induce apoptosis in paclitaxel-resistant ovarian cancer cells through hTERT and Bcl-2 down-regulation.	sulforaphane	29-41	BCL2 apoptosis regulator	Homo sapiens	144-149
23333498-8	2013	Combined EGCG and SFN treatment increases apoptosis significantly in paclitaxel-resistant SKOV3TR-ip2 cells after 6 days of treatment, while reducing the expression of hTERT, the main regulatory subunit of telomerase.	sulforaphane	18-21	telomerase reverse transcriptase	Homo sapiens	168-173
23333498-11	2013	Furthermore, phosphorylated H2AX is up-regulated after 6 days of treatment with SFN alone, and EGCG can potentiate this effect, suggesting that DNA damage is a potential cellular mechanism contributing to the inhibiting effect of EGCG and SFN combination treatment.	sulforaphane	80-83	H2A.X variant histone	Homo sapiens	28-32
23333498-11	2013	Furthermore, phosphorylated H2AX is up-regulated after 6 days of treatment with SFN alone, and EGCG can potentiate this effect, suggesting that DNA damage is a potential cellular mechanism contributing to the inhibiting effect of EGCG and SFN combination treatment.	sulforaphane	239-242	H2A.X variant histone	Homo sapiens	28-32
23333498-12	2013	Taken together, these results indicate that EGCG and SFN combination treatment can induce apoptosis by down-regulating of hTERT and Bcl-2 and promote DNA damage response specifically in paclitaxel-resistant ovarian cancer cell lines and suggest the use of these compounds for overcoming paclitaxel resistance in ovarian cancer treatment.	sulforaphane	53-56	telomerase reverse transcriptase	Homo sapiens	122-127
23333498-12	2013	Taken together, these results indicate that EGCG and SFN combination treatment can induce apoptosis by down-regulating of hTERT and Bcl-2 and promote DNA damage response specifically in paclitaxel-resistant ovarian cancer cell lines and suggest the use of these compounds for overcoming paclitaxel resistance in ovarian cancer treatment.	sulforaphane	53-56	BCL2 apoptosis regulator	Homo sapiens	132-137
23254561-9	2013	The combination of SFN and 2 Gy radiation increased the cleavage and             activation of caspase-3 compared with SFN or radiation alone, as shown by western             blotting.	sulforaphane	19-22	caspase 3	Mus musculus	95-104
23254561-11	2013	We found that SFN enhanced             the radiosensitivity of LM8 murine osteosarcoma cells by inducing apoptosis through             G2/M-phase arrest and by inhibiting ERK and Akt activation.	sulforaphane	14-17	mitogen-activated protein kinase 1	Mus musculus	171-174
23254561-11	2013	We found that SFN enhanced             the radiosensitivity of LM8 murine osteosarcoma cells by inducing apoptosis through             G2/M-phase arrest and by inhibiting ERK and Akt activation.	sulforaphane	14-17	thymoma viral proto-oncogene 1	Mus musculus	179-182
26105875-11	2013	CONCLUSION: The activation of HO-1/CO via Nrf2 inducer such as sulforaphane inhibited in vitro the release of sFlt-1, thus the activation of Nrf2 during the first trimester may improve the balance of the pro- and anti-angiogenic factors.	sulforaphane	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
26105875-11	2013	CONCLUSION: The activation of HO-1/CO via Nrf2 inducer such as sulforaphane inhibited in vitro the release of sFlt-1, thus the activation of Nrf2 during the first trimester may improve the balance of the pro- and anti-angiogenic factors.	sulforaphane	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	141-145
23271678-1	2013	The anti-carcinogenic effects of sulforaphane (SFN) are based on the up-regulation of antioxidant enzymes (AE) and phase II enzymes (PIIE) through the transcription factor Nrf2.	sulforaphane	33-45	NFE2 like bZIP transcription factor 2	Rattus norvegicus	172-176
23271678-1	2013	The anti-carcinogenic effects of sulforaphane (SFN) are based on the up-regulation of antioxidant enzymes (AE) and phase II enzymes (PIIE) through the transcription factor Nrf2.	sulforaphane	47-50	NFE2 like bZIP transcription factor 2	Rattus norvegicus	172-176
23195333-4	2013	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, enhances Nrf2 activity.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
23195333-4	2013	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, enhances Nrf2 activity.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
23195333-5	2013	Therefore, we hypothesized that SFN supplementation induces SLPI secretion in the nasal mucosa in an Nrf2 dependent manner.	sulforaphane	32-35	secretory leukocyte peptidase inhibitor	Homo sapiens	60-64
23195333-5	2013	Therefore, we hypothesized that SFN supplementation induces SLPI secretion in the nasal mucosa in an Nrf2 dependent manner.	sulforaphane	32-35	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
23195333-11	2013	SFN supplementation in vitro significantly enhanced SLPI secretion and these effects were significantly decreased in cells transduced with Nrf2-specific shRNA.	sulforaphane	0-3	secretory leukocyte peptidase inhibitor	Homo sapiens	52-56
23195333-11	2013	SFN supplementation in vitro significantly enhanced SLPI secretion and these effects were significantly decreased in cells transduced with Nrf2-specific shRNA.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
23195333-13	2013	Therefore, ingestion of SFN-containing foods has therapeutic potential to augment SLPI expression in the nasal mucosa.	sulforaphane	24-27	secretory leukocyte peptidase inhibitor	Homo sapiens	82-86
23663345-0	2013	[Effects of autophagy modulator on autophagy and uridine 5"-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane].	sulforaphane	109-121	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	49-97
23663345-1	2013	OBJECTIVE: To explore the effects of 3-methyladenine (3-MA) and rapamycin (Rapa) on autophagy and uridine 5"-diphospho-glucuronosyltransferase 1A1 (UGT1A1) induced by sulforaphane (SFN) in human colon cancer Caco-2 cells.	sulforaphane	167-179	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	98-146
23663345-1	2013	OBJECTIVE: To explore the effects of 3-methyladenine (3-MA) and rapamycin (Rapa) on autophagy and uridine 5"-diphospho-glucuronosyltransferase 1A1 (UGT1A1) induced by sulforaphane (SFN) in human colon cancer Caco-2 cells.	sulforaphane	181-184	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	98-146
23663345-10	2013	There was no obvious nuclear staining of Nrf2 in control group while intense nuclear fluorescent labeling of Nrf2 could be observed in the SFN-treated groups, especially the combination group of SFN and Rapa.	sulforaphane	139-142	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
23663345-10	2013	There was no obvious nuclear staining of Nrf2 in control group while intense nuclear fluorescent labeling of Nrf2 could be observed in the SFN-treated groups, especially the combination group of SFN and Rapa.	sulforaphane	195-198	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
23663345-13	2013	And Rapa also potentiates SFN-induced UGT1A1 expression.	sulforaphane	26-29	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	38-44
23581983-7	2013	Widely known natural Keap1-Nrf2 activators include curcumin, quercetin, resveratrol, and sulforaphane.	sulforaphane	89-101	kelch like ECH associated protein 1	Homo sapiens	21-26
23581983-7	2013	Widely known natural Keap1-Nrf2 activators include curcumin, quercetin, resveratrol, and sulforaphane.	sulforaphane	89-101	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
23188707-7	2013	The mechanism(s) by which known Nrf2 activators, such as the natural chemopreventive compounds SF and lipoic acid, protect against the deleterious effects caused by arsenic will also be discussed.	sulforaphane	95-97	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
23201461-4	2013	Furthermore, a glutathione S-transferase, GSTA4, is also induced in mouse skin by sulforaphane.	sulforaphane	82-94	hematopoietic prostaglandin D synthase	Mus musculus	15-40
23201461-4	2013	Furthermore, a glutathione S-transferase, GSTA4, is also induced in mouse skin by sulforaphane.	sulforaphane	82-94	glutathione S-transferase, alpha 4	Mus musculus	42-47
23129257-10	2013	Since aberrant Shh signaling occurs in pancreatic tumorigenesis, therapeutics that target Shh pathway may improve the outcomes of patients with pancreatic cancer by targeting CSCs, thus suggesting the use of sulforaphane to further improve preventive and therapeutic approaches in patients with this devastating disease.	sulforaphane	208-220	sonic hedgehog signaling molecule	Homo sapiens	90-93
23476648-0	2013	Enhancement of Cisplatin-Mediated Apoptosis in Ovarian Cancer Cells through Potentiating G2/M Arrest and p21 Upregulation by Combinatorial Epigallocatechin Gallate and Sulforaphane.	sulforaphane	168-180	H3 histone pseudogene 16	Homo sapiens	105-108
23476648-5	2013	In this study, EGCG or SFN was used to treat both cisplatin-sensitive (A2780) and cisplatin-resistant (A2780/CP20) ovarian cancer cells alone or in combination with cisplatin.	sulforaphane	23-26	lymphocyte cytosolic protein, molecular weight 20kD	Homo sapiens	109-113
23476648-8	2013	EGCG and SFN combinational treatment upregulated p21 expression induced by cisplatin in cisplatin-sensitive ovarian cancer cells, while p27 expression was not regulated by these treatments.	sulforaphane	9-12	H3 histone pseudogene 16	Homo sapiens	49-52
22703534-12	2013	INNOVATION AND CONCLUSION: Our findings confirm that decreased nuclear Nrf2 plays a role in myofibroblastic differentiation and that SFN induces human pulmonary fibroblast dedifferentiation in vitro via Nrf2 activation.	sulforaphane	133-136	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
24187484-0	2013	Sulforaphane-induced transcription of thioredoxin reductase in lens: possible significance against cataract formation.	sulforaphane	0-12	peroxiredoxin 2	Mus musculus	38-59
24187484-11	2013	RESULTS: The activity of TrxR in the lenses incubated with sulforaphane was found to be elevated to 18 times of that observed in lenses incubated without sulforaphane.	sulforaphane	59-71	peroxiredoxin 2	Mus musculus	25-29
24187484-11	2013	RESULTS: The activity of TrxR in the lenses incubated with sulforaphane was found to be elevated to 18 times of that observed in lenses incubated without sulforaphane.	sulforaphane	154-166	peroxiredoxin 2	Mus musculus	25-29
24187484-14	2013	CONCLUSION: Sulforaphane has been found to enhance TrxR activity in the mouse lens in culture.	sulforaphane	12-24	peroxiredoxin 2	Mus musculus	51-55
23662110-9	2013	In addition, SFN was able to prevent GM-induced protein nitration and decrease in the activity of antioxidant enzymes catalase and glutathione peroxidase in renal cortex.	sulforaphane	13-16	catalase	Rattus norvegicus	118-126
23129257-0	2013	Sulforaphane regulates self-renewal of pancreatic cancer stem cells through the modulation of Sonic hedgehog-GLI pathway.	sulforaphane	0-12	GLI family zinc finger 1	Homo sapiens	109-112
23129257-4	2013	We show here for the first time that sulforaphane treatment resulted in a significant reduction in the tumor growth of orthotopically implanted primary pancreatic CSCs isolated from human pancreatic tumors into the pancreas of NOD/SCID/IL2Rgamma mice, which is mediated through the modulation of Sonic hedgehog-GLI signaling.	sulforaphane	37-49	atrophin 1	Homo sapiens	227-230
23129257-4	2013	We show here for the first time that sulforaphane treatment resulted in a significant reduction in the tumor growth of orthotopically implanted primary pancreatic CSCs isolated from human pancreatic tumors into the pancreas of NOD/SCID/IL2Rgamma mice, which is mediated through the modulation of Sonic hedgehog-GLI signaling.	sulforaphane	37-49	GLI family zinc finger 1	Homo sapiens	311-314
23368923-5	2013	Compared to the structurally related sulforaphane, a well-studied broccoli-derived ITC, ER showed lower potency in inhibiting proliferation of PC3 cells, as well as in modulating p21 and pERK1/2 protein levels.	sulforaphane	37-49	proprotein convertase subtilisin/kexin type 1	Homo sapiens	143-146
23129257-5	2013	Hedgehog pathway blockade by SFN at a dose of 20 mg/kg resulted in a 45 % reduction in growth of pancreatic cancer tumors and reduced expression of Shh pathway components, Smo, Gli 1, and Gli 2 in mouse tissues.	sulforaphane	29-32	sonic hedgehog	Mus musculus	148-151
23129257-5	2013	Hedgehog pathway blockade by SFN at a dose of 20 mg/kg resulted in a 45 % reduction in growth of pancreatic cancer tumors and reduced expression of Shh pathway components, Smo, Gli 1, and Gli 2 in mouse tissues.	sulforaphane	29-32	smoothened, frizzled class receptor	Mus musculus	172-175
23129257-5	2013	Hedgehog pathway blockade by SFN at a dose of 20 mg/kg resulted in a 45 % reduction in growth of pancreatic cancer tumors and reduced expression of Shh pathway components, Smo, Gli 1, and Gli 2 in mouse tissues.	sulforaphane	29-32	GLI-Kruppel family member GLI1	Mus musculus	177-182
23129257-5	2013	Hedgehog pathway blockade by SFN at a dose of 20 mg/kg resulted in a 45 % reduction in growth of pancreatic cancer tumors and reduced expression of Shh pathway components, Smo, Gli 1, and Gli 2 in mouse tissues.	sulforaphane	29-32	GLI-Kruppel family member GLI2	Mus musculus	188-193
23129257-7	2013	Furthermore, SFN treatment resulted in a significant reduction in EMT markers Zeb-1, which correlated with increase in E-Cadherin expression suggesting the blockade of signaling involved in early metastasis.	sulforaphane	13-16	IL2 inducible T cell kinase	Homo sapiens	66-69
23129257-7	2013	Furthermore, SFN treatment resulted in a significant reduction in EMT markers Zeb-1, which correlated with increase in E-Cadherin expression suggesting the blockade of signaling involved in early metastasis.	sulforaphane	13-16	zinc finger E-box binding homeobox 1	Homo sapiens	78-83
23129257-7	2013	Furthermore, SFN treatment resulted in a significant reduction in EMT markers Zeb-1, which correlated with increase in E-Cadherin expression suggesting the blockade of signaling involved in early metastasis.	sulforaphane	13-16	cadherin 1	Homo sapiens	119-129
23129257-9	2013	These data demonstrate that, at a tolerable dose, inhibition of Shh pathway by SFN results in marked reduction in EMT, metastatic, angiogenic markers with significant inhibition in tumor growth in mice.	sulforaphane	79-82	sonic hedgehog	Mus musculus	64-67
23129257-9	2013	These data demonstrate that, at a tolerable dose, inhibition of Shh pathway by SFN results in marked reduction in EMT, metastatic, angiogenic markers with significant inhibition in tumor growth in mice.	sulforaphane	79-82	IL2 inducible T cell kinase	Homo sapiens	114-117
23441612-5	2013	In our study, using global expression profiling based on TaqMan Low-Density Arrays, we identified 3 common miRNAs (miR-155, miR-23b, miR-27b) regulated by ITCs (sulforaphane, iberin) in colonic epithelial cell lines NCM460 and NCM356.	sulforaphane	161-173	microRNA 23b	Homo sapiens	124-131
23441612-5	2013	In our study, using global expression profiling based on TaqMan Low-Density Arrays, we identified 3 common miRNAs (miR-155, miR-23b, miR-27b) regulated by ITCs (sulforaphane, iberin) in colonic epithelial cell lines NCM460 and NCM356.	sulforaphane	161-173	microRNA 27b	Homo sapiens	133-140
23441612-5	2013	In our study, using global expression profiling based on TaqMan Low-Density Arrays, we identified 3 common miRNAs (miR-155, miR-23b, miR-27b) regulated by ITCs (sulforaphane, iberin) in colonic epithelial cell lines NCM460 and NCM356.	sulforaphane	161-173	microRNA 155	Homo sapiens	115-122
23766848-3	2013	Using the dietary isothiocyanate sulforaphane (SFN) to activate NRF2, chromatin immunoprecipitation sequencing (ChIP-seq) identified several hundred novel NRF2-mediated targets beyond its role in oxidative stress.	sulforaphane	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
23766848-3	2013	Using the dietary isothiocyanate sulforaphane (SFN) to activate NRF2, chromatin immunoprecipitation sequencing (ChIP-seq) identified several hundred novel NRF2-mediated targets beyond its role in oxidative stress.	sulforaphane	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
23533698-5	2013	Importantly, Nrf2(-/-) recipient mice could not support the graft for longer than 7.5 days on average, whereas activation of Nrf2 by sulforaphane in Nrf2(+/+) hosts prolonged graft survival to 13 days.	sulforaphane	133-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
23864927-8	2013	The protective effect of SUL against Abeta(25-35)-induced apoptotic cell death was abolished by siRNA of Nrf2.	sulforaphane	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
23533698-5	2013	Importantly, Nrf2(-/-) recipient mice could not support the graft for longer than 7.5 days on average, whereas activation of Nrf2 by sulforaphane in Nrf2(+/+) hosts prolonged graft survival to 13 days.	sulforaphane	133-145	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
23864927-3	2013	In this study, we aimed to investigate effects of sulforaphane (SUL), an isothiocyanate in cruciferous vegetables, on Abeta-induced oxidative cell death in SH-SY5Y cells.	sulforaphane	50-62	amyloid beta precursor protein	Homo sapiens	118-123
23983898-4	2013	In particular, evidence suggests that sulforaphane beneficial effects could be mainly ascribed to its peculiar ability to activate the Nrf2/ARE pathway.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
23864927-3	2013	In this study, we aimed to investigate effects of sulforaphane (SUL), an isothiocyanate in cruciferous vegetables, on Abeta-induced oxidative cell death in SH-SY5Y cells.	sulforaphane	64-67	amyloid beta precursor protein	Homo sapiens	118-123
23864927-7	2013	SUL exerted antioxidant potential by upregulating expression of antioxidant enzymes including gamma-glutamylcysteine ligase, NAD(P)H:quinone oxidoreductase-1, and heme oxygenase-1 via activation of NF-E2-related factor 2(Nrf2).	sulforaphane	0-3	NAD(P)H quinone dehydrogenase 1	Homo sapiens	125-157
23864927-7	2013	SUL exerted antioxidant potential by upregulating expression of antioxidant enzymes including gamma-glutamylcysteine ligase, NAD(P)H:quinone oxidoreductase-1, and heme oxygenase-1 via activation of NF-E2-related factor 2(Nrf2).	sulforaphane	0-3	heme oxygenase 1	Homo sapiens	163-179
23864927-7	2013	SUL exerted antioxidant potential by upregulating expression of antioxidant enzymes including gamma-glutamylcysteine ligase, NAD(P)H:quinone oxidoreductase-1, and heme oxygenase-1 via activation of NF-E2-related factor 2(Nrf2).	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	221-225
22752583-0	2013	Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.	sulforaphane	56-68	kelch like ECH associated protein 1	Homo sapiens	0-5
23864927-8	2013	The protective effect of SUL against Abeta(25-35)-induced apoptotic cell death was abolished by siRNA of Nrf2.	sulforaphane	25-28	amyloid beta precursor protein	Homo sapiens	37-42
22752583-0	2013	Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane.	sulforaphane	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	6-10
22752583-4	2013	Interaction of sulforaphane with Keap1 disrupts this function and allows for nuclear accumulation of Nrf2 and activation of its transcriptional program.	sulforaphane	15-27	kelch like ECH associated protein 1	Homo sapiens	33-38
22752583-4	2013	Interaction of sulforaphane with Keap1 disrupts this function and allows for nuclear accumulation of Nrf2 and activation of its transcriptional program.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
22424477-3	2012	Following phytochemical treatment, a significant increase in mRNA of glutathione S-transferase A1 (GSTA1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) was observed, with the most marked increases seen in response to sulphoraphane (3-10-fold for GSTA1, P = 0 001, and 6-35-fold for NQO1, P = 0 001-0 017).	sulforaphane	215-228	glutathione S-transferase alpha 1	Homo sapiens	69-97
23153560-1	2013	Sulforaphane (SFN), is an effective in vitro antagonist of ligand activation of the human pregnane and xenobiotic receptor (PXR).	sulforaphane	0-12	nuclear receptor subfamily 1 group I member 2	Homo sapiens	124-127
23153560-1	2013	Sulforaphane (SFN), is an effective in vitro antagonist of ligand activation of the human pregnane and xenobiotic receptor (PXR).	sulforaphane	14-17	nuclear receptor subfamily 1 group I member 2	Homo sapiens	124-127
23153560-4	2013	To evaluate whether SFN can effectively antagonize ligand activation of human PXR in vivo, a three-armed, randomized, crossover trial was conducted with 24 healthy adults.	sulforaphane	20-23	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81
23153560-9	2013	Treatment with SFN alone also did not affect CYP3A4 activity in the cohort as a whole, although in the subset with the highest basal CYP3A4 activity there was a statistically significant increase in midazolam AUC (i.e., decrease in CYP3A4 activity).	sulforaphane	15-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139
23153560-9	2013	Treatment with SFN alone also did not affect CYP3A4 activity in the cohort as a whole, although in the subset with the highest basal CYP3A4 activity there was a statistically significant increase in midazolam AUC (i.e., decrease in CYP3A4 activity).	sulforaphane	15-18	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139
22424477-3	2012	Following phytochemical treatment, a significant increase in mRNA of glutathione S-transferase A1 (GSTA1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) was observed, with the most marked increases seen in response to sulphoraphane (3-10-fold for GSTA1, P = 0 001, and 6-35-fold for NQO1, P = 0 001-0 017).	sulforaphane	215-228	glutathione S-transferase alpha 1	Homo sapiens	99-104
22424477-3	2012	Following phytochemical treatment, a significant increase in mRNA of glutathione S-transferase A1 (GSTA1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) was observed, with the most marked increases seen in response to sulphoraphane (3-10-fold for GSTA1, P = 0 001, and 6-35-fold for NQO1, P = 0 001-0 017).	sulforaphane	215-228	NAD(P)H quinone dehydrogenase 1	Homo sapiens	110-142
22424477-3	2012	Following phytochemical treatment, a significant increase in mRNA of glutathione S-transferase A1 (GSTA1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) was observed, with the most marked increases seen in response to sulphoraphane (3-10-fold for GSTA1, P = 0 001, and 6-35-fold for NQO1, P = 0 001-0 017).	sulforaphane	215-228	NAD(P)H quinone dehydrogenase 1	Homo sapiens	144-148
22424477-5	2012	Moreover, NQO1 protein levels were significantly increased in 2-year-old and adult cell models in response to sulphoraphane treatment.	sulforaphane	110-123	NAD(P)H quinone dehydrogenase 1	Homo sapiens	10-14
22975029-0	2012	Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
22975029-6	2012	Two-week exposure to arsenic-containing dust resulted in pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung; all of which were blocked by sulforaphane (SF) in an Nrf2-dependent manner.	sulforaphane	177-189	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
22975029-6	2012	Two-week exposure to arsenic-containing dust resulted in pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung; all of which were blocked by sulforaphane (SF) in an Nrf2-dependent manner.	sulforaphane	191-193	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
23540163-9	2012	After the treatment of UUO rats with sulforaphane, approximately 24%, 45%, and 26% of the volume of the PCT, DCT and Henle"s loop remained intact, respectively (p < 0.01).	sulforaphane	37-49	dopachrome tautomerase	Rattus norvegicus	109-112
23540163-11	2012	After the treatment of UUO rats with sulforaphane, approximately 42% and 41% of the length of the PCT and DCT remained intact, respectively (p < 0.01).	sulforaphane	37-49	dopachrome tautomerase	Rattus norvegicus	106-109
22983983-2	2012	Sulforaphane, an isothiocyanate derived from broccoli, is a potent inducer of endogenous cellular defenses regulated by transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), including cytoprotective enzymes and glutathione, which in turn act as efficient indirect and direct antioxidants that have long-lasting effects.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	141-184
22983983-2	2012	Sulforaphane, an isothiocyanate derived from broccoli, is a potent inducer of endogenous cellular defenses regulated by transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), including cytoprotective enzymes and glutathione, which in turn act as efficient indirect and direct antioxidants that have long-lasting effects.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	186-190
23092945-6	2012	Compared with TSA and 5-aza-2"-deoxycytidine (5-aza-dC), SFN treatment significantly represses MSTN expression, accompanied by strongly attenuated expression of negative feedback inhibitors of the MSTN signaling pathway.	sulforaphane	57-60	myostatin	Homo sapiens	95-99
22936178-9	2012	Nrf2 activation via Keap1-KD or sulforaphane suppressed hormone-induced differentiation and decreased peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein alpha, and fatty acid-binding protein 4 expression in mouse embryonic fibroblasts.	sulforaphane	32-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
22936178-9	2012	Nrf2 activation via Keap1-KD or sulforaphane suppressed hormone-induced differentiation and decreased peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein alpha, and fatty acid-binding protein 4 expression in mouse embryonic fibroblasts.	sulforaphane	32-44	peroxisome proliferator activated receptor gamma	Mus musculus	102-150
22936178-9	2012	Nrf2 activation via Keap1-KD or sulforaphane suppressed hormone-induced differentiation and decreased peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein alpha, and fatty acid-binding protein 4 expression in mouse embryonic fibroblasts.	sulforaphane	32-44	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	152-188
22936178-9	2012	Nrf2 activation via Keap1-KD or sulforaphane suppressed hormone-induced differentiation and decreased peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding protein alpha, and fatty acid-binding protein 4 expression in mouse embryonic fibroblasts.	sulforaphane	32-44	fatty acid binding protein 4, adipocyte	Mus musculus	194-222
23092945-6	2012	Compared with TSA and 5-aza-2"-deoxycytidine (5-aza-dC), SFN treatment significantly represses MSTN expression, accompanied by strongly attenuated expression of negative feedback inhibitors of the MSTN signaling pathway.	sulforaphane	57-60	myostatin	Homo sapiens	197-201
23092945-0	2012	Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells.	sulforaphane	0-12	myostatin	Homo sapiens	53-62
22975350-4	2012	The present study was designed to investigate the role of sulphoraphane, a natural isothiocyanate on HSPs (27, 70, 90) and HSF1 in two different breast cancer cell lines MCF-7 and MDA-MB-231 cells expressing wild type and mutated p53 respectively, vis-a-vis in normal breast epithelial cell line MCF-12F.	sulforaphane	58-71	heat shock transcription factor 1	Homo sapiens	123-127
23092945-3	2012	Human diet contains many histone deacetylase (HDAC) inhibitors, such as the bioactive component sulforaphane (SFN), whose epigenetic effects on MSTN gene in satellite cells are unknown.	sulforaphane	96-108	myostatin	Homo sapiens	144-148
23092945-3	2012	Human diet contains many histone deacetylase (HDAC) inhibitors, such as the bioactive component sulforaphane (SFN), whose epigenetic effects on MSTN gene in satellite cells are unknown.	sulforaphane	110-113	myostatin	Homo sapiens	144-148
23092945-5	2012	The present work provides the first evidence, which is distinct from the effects of trichostatin A (TSA), that SFN supplementation in vitro not only acts as a HDAC inhibitor but also as a DNA methyltransferase (DNMT) inhibitor in porcine satellite cells.	sulforaphane	111-114	DNA methyltransferase 1	Homo sapiens	188-209
23092945-5	2012	The present work provides the first evidence, which is distinct from the effects of trichostatin A (TSA), that SFN supplementation in vitro not only acts as a HDAC inhibitor but also as a DNA methyltransferase (DNMT) inhibitor in porcine satellite cells.	sulforaphane	111-114	DNA methyltransferase 1	Homo sapiens	211-215
22898620-7	2012	RESULTS: Sulforaphane inhibited the mRNA and protein expression of VCAM-1 induced by tumor necrosis factor (TNF)-alpha in VSMCs.	sulforaphane	9-21	vascular cell adhesion molecule 1	Rattus norvegicus	67-73
22898620-7	2012	RESULTS: Sulforaphane inhibited the mRNA and protein expression of VCAM-1 induced by tumor necrosis factor (TNF)-alpha in VSMCs.	sulforaphane	9-21	tumor necrosis factor	Rattus norvegicus	85-118
22898620-8	2012	Treatment of VSMCs with sulforaphane blocked TNF-alpha-induced IkappaBalpha degradation and NF-kappaB p65 and GATA6 expression.	sulforaphane	24-36	tumor necrosis factor	Rattus norvegicus	45-54
22898620-8	2012	Treatment of VSMCs with sulforaphane blocked TNF-alpha-induced IkappaBalpha degradation and NF-kappaB p65 and GATA6 expression.	sulforaphane	24-36	NFKB inhibitor alpha	Rattus norvegicus	63-75
22898620-8	2012	Treatment of VSMCs with sulforaphane blocked TNF-alpha-induced IkappaBalpha degradation and NF-kappaB p65 and GATA6 expression.	sulforaphane	24-36	synaptotagmin 1	Rattus norvegicus	102-105
22898620-8	2012	Treatment of VSMCs with sulforaphane blocked TNF-alpha-induced IkappaBalpha degradation and NF-kappaB p65 and GATA6 expression.	sulforaphane	24-36	GATA binding protein 6	Rattus norvegicus	110-115
22898620-9	2012	Furthermore, NF-kappaB p65 and GATA6 expression were reduced in sulforaphane-treated carotid injury sections.	sulforaphane	64-76	synaptotagmin 1	Rattus norvegicus	23-26
22898620-9	2012	Furthermore, NF-kappaB p65 and GATA6 expression were reduced in sulforaphane-treated carotid injury sections.	sulforaphane	64-76	GATA binding protein 6	Rattus norvegicus	31-36
22898620-10	2012	Notably, binding of GATA6 to the VCAM-1 promoter was dramatically reduced by sulforaphane.	sulforaphane	77-89	GATA binding protein 6	Rattus norvegicus	20-25
22898620-10	2012	Notably, binding of GATA6 to the VCAM-1 promoter was dramatically reduced by sulforaphane.	sulforaphane	77-89	vascular cell adhesion molecule 1	Rattus norvegicus	33-39
22898620-13	2012	CONCLUSIONS: Our results indicate that sulforaphane inhibits neointima formation via targeting of adhesion molecules through the suppression of NF-kappaB/GATA6.	sulforaphane	39-51	GATA binding protein 6	Rattus norvegicus	154-159
22853439-3	2012	Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes.	sulforaphane	0-12	Kelch-like ECH-associated protein 1	Rattus norvegicus	107-112
22853439-3	2012	Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	113-117
22853439-3	2012	Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	205-238
22941232-5	2012	SFN induced cell cycle arrest at the G2/M phase by downregulation of cyclin B,             cdc2 and cdc25c and upregulation of p21WAF1/CIP1 and p53 in a dose- and time-dependent             manner, as determined by western blot analysis.	sulforaphane	0-3	M-phase inducer phosphatase 3	Oryctolagus cuniculus	100-106
22949501-5	2012	The nrf2(fh318) larvae displayed enhanced sensitivity to oxidative stress and electrophiles, especially peroxides, and pretreatment with an Nrf2-activating compound, sulforaphane, decreased peroxide-induced lethality in the wild type but not nrf2(fh318) mutants, indicating that resistance to oxidative stress is highly dependent on Nrf2 functions.	sulforaphane	166-178	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8
22949501-5	2012	The nrf2(fh318) larvae displayed enhanced sensitivity to oxidative stress and electrophiles, especially peroxides, and pretreatment with an Nrf2-activating compound, sulforaphane, decreased peroxide-induced lethality in the wild type but not nrf2(fh318) mutants, indicating that resistance to oxidative stress is highly dependent on Nrf2 functions.	sulforaphane	166-178	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
22949501-5	2012	The nrf2(fh318) larvae displayed enhanced sensitivity to oxidative stress and electrophiles, especially peroxides, and pretreatment with an Nrf2-activating compound, sulforaphane, decreased peroxide-induced lethality in the wild type but not nrf2(fh318) mutants, indicating that resistance to oxidative stress is highly dependent on Nrf2 functions.	sulforaphane	166-178	nuclear factor, erythroid derived 2, like 2	Mus musculus	242-246
22949501-5	2012	The nrf2(fh318) larvae displayed enhanced sensitivity to oxidative stress and electrophiles, especially peroxides, and pretreatment with an Nrf2-activating compound, sulforaphane, decreased peroxide-induced lethality in the wild type but not nrf2(fh318) mutants, indicating that resistance to oxidative stress is highly dependent on Nrf2 functions.	sulforaphane	166-178	nuclear factor, erythroid derived 2, like 2	Mus musculus	333-337
22922937-7	2012	ATO and sulforaphane co-treatment augmented apoptotic induction as demonstrated             by cleavage of caspase-3, -4 and PARP.	sulforaphane	8-20	caspase 3	Homo sapiens	107-120
22922937-7	2012	ATO and sulforaphane co-treatment augmented apoptotic induction as demonstrated             by cleavage of caspase-3, -4 and PARP.	sulforaphane	8-20	collagen type XI alpha 2 chain	Homo sapiens	125-129
23072510-0	2012	Sulforaphane has opposing effects on TNF-alpha stimulated and unstimulated synoviocytes.	sulforaphane	0-12	tumor necrosis factor	Homo sapiens	37-46
23072510-4	2012	We used sulforaphane, an isothiocyanate, which is both an Nrf2 inducer and a NF-kappaB and AP-1 inhibitor.	sulforaphane	8-20	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
23072510-4	2012	We used sulforaphane, an isothiocyanate, which is both an Nrf2 inducer and a NF-kappaB and AP-1 inhibitor.	sulforaphane	8-20	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-95
23072510-15	2012	In marked contrast to this, SFN induced apoptosis in TNF-alpha-pre-stimulated synoviocytes.	sulforaphane	28-31	tumor necrosis factor	Homo sapiens	53-62
23072510-17	2012	SFN induces the cytoprotective transcription factor Nrf2 in naive synoviocytes, whereas it induces apoptosis in inflamed synoviocytes.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
22444872-0	2012	Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.	sulforaphane	0-12	heat shock protein, 3	Mus musculus	59-64
22444872-0	2012	Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.	sulforaphane	0-12	cell division cycle 37	Mus musculus	65-68
22444872-0	2012	Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.	sulforaphane	0-12	cell division cycle 37	Mus musculus	69-74
22444872-0	2012	Sulforaphane inhibits pancreatic cancer through disrupting Hsp90-p50(Cdc37) complex and direct interactions with amino acids residues of Hsp90.	sulforaphane	0-12	heat shock protein, 3	Mus musculus	137-142
22444872-5	2012	We found that sulforaphane induced the degradation of heat shock protein 90 (Hsp90) client proteins and blocked the interaction of Hsp90 with its cochaperone p50(Cdc37) in pancreatic cancer cells.	sulforaphane	14-26	heat shock protein, 3	Mus musculus	54-75
22444872-5	2012	We found that sulforaphane induced the degradation of heat shock protein 90 (Hsp90) client proteins and blocked the interaction of Hsp90 with its cochaperone p50(Cdc37) in pancreatic cancer cells.	sulforaphane	14-26	heat shock protein, 3	Mus musculus	77-82
22444872-5	2012	We found that sulforaphane induced the degradation of heat shock protein 90 (Hsp90) client proteins and blocked the interaction of Hsp90 with its cochaperone p50(Cdc37) in pancreatic cancer cells.	sulforaphane	14-26	heat shock protein, 3	Mus musculus	131-136
22444872-5	2012	We found that sulforaphane induced the degradation of heat shock protein 90 (Hsp90) client proteins and blocked the interaction of Hsp90 with its cochaperone p50(Cdc37) in pancreatic cancer cells.	sulforaphane	14-26	cell division cycle 37	Mus musculus	158-161
22444872-5	2012	We found that sulforaphane induced the degradation of heat shock protein 90 (Hsp90) client proteins and blocked the interaction of Hsp90 with its cochaperone p50(Cdc37) in pancreatic cancer cells.	sulforaphane	14-26	cell division cycle 37	Mus musculus	162-167
22444872-6	2012	Using nuclear magnetic resonance spectroscopy (NMR) with an isoleucine-specific labeling strategy, we overcame the protein size limit of conventional NMR and studied the interaction of sulforaphane with full-length Hsp90 dimer (170 kDa) in solution.	sulforaphane	185-197	heat shock protein, 3	Mus musculus	215-220
22444872-7	2012	NMR revealed multiple chemical shifts in sheet 2 and the adjacent loop in Hsp90 N-terminal domain after incubation of Hsp90 with sulforaphane.	sulforaphane	129-141	heat shock protein, 3	Mus musculus	74-79
22444872-7	2012	NMR revealed multiple chemical shifts in sheet 2 and the adjacent loop in Hsp90 N-terminal domain after incubation of Hsp90 with sulforaphane.	sulforaphane	129-141	heat shock protein, 3	Mus musculus	118-123
22444872-9	2012	These data suggest a new mechanism of sulforaphane that disrupts protein-protein interaction in Hsp90 complex for its chemopreventive activity.	sulforaphane	38-50	heat shock protein, 3	Mus musculus	96-101
22853439-3	2012	Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes.	sulforaphane	14-16	Kelch-like ECH-associated protein 1	Rattus norvegicus	107-112
22853439-3	2012	Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes.	sulforaphane	14-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	113-117
22853439-3	2012	Sulforaphane (SF), an isothiocyanate derived from broccoli, is a potent naturally-occurring inducer of the Keap1/Nrf2/ARE pathway, leading to upregulation of genes encoding cytoprotective proteins such as NAD(P)H: quinone oxidoreductase 1, and GSH-regulatory enzymes.	sulforaphane	14-16	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	205-238
22853439-7	2012	SF (50 mg/kg) treatment resulted in both acute and long-term beneficial effects, including upregulation of the phase 2 antioxidant response at the injury site, decreased mRNA levels of inflammatory cytokines (i.e., MMP-9) in the injured spinal cord, inactivation of urinary MIF tautomerase activity, enhanced hindlimb locomotor function, and an increased number of serotonergic axons caudal to the lesion site.	sulforaphane	0-2	matrix metallopeptidase 9	Rattus norvegicus	215-220
22853439-7	2012	SF (50 mg/kg) treatment resulted in both acute and long-term beneficial effects, including upregulation of the phase 2 antioxidant response at the injury site, decreased mRNA levels of inflammatory cytokines (i.e., MMP-9) in the injured spinal cord, inactivation of urinary MIF tautomerase activity, enhanced hindlimb locomotor function, and an increased number of serotonergic axons caudal to the lesion site.	sulforaphane	0-2	macrophage migration inhibitory factor	Rattus norvegicus	274-277
22922937-5	2012	We found that sulforaphane, a dietary isothiocyanate             found in cruciferous vegetables, inhibits TNFalpha-induced Ikappabeta proteasomal degradation             in a manner similar to BTZ.	sulforaphane	14-26	tumor necrosis factor	Homo sapiens	107-115
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	sulforaphane	118-130	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	24-29
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	sulforaphane	118-130	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-38
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	sulforaphane	118-130	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	208-213
22932898-2	2012	We recently showed that Bmi-1 and Ezh2 protein level is reduced by treatment with the dietary chemopreventive agents, sulforaphane and green tea polyphenol, and that this reduction involves ubiquitination of Bmi-1 and Ezh2, suggesting a key role of the proteasome.	sulforaphane	118-130	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	218-222
23061798-12	2012	Furthermore, the known NRF2 small molecule activators CDDO and Sulphoraphane can also dose dependently inhibit Eotaxin-1 release from human lung fibroblasts.	sulforaphane	63-76	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
23061798-12	2012	Furthermore, the known NRF2 small molecule activators CDDO and Sulphoraphane can also dose dependently inhibit Eotaxin-1 release from human lung fibroblasts.	sulforaphane	63-76	C-C motif chemokine ligand 11	Homo sapiens	111-120
22975350-6	2012	Sulphoraphane was found to down-regulate the expressions of HSP70, 90 and HSF1, though the effect on HSP27 was not pronounced.	sulforaphane	0-13	heat shock protein family A (Hsp70) member 4	Homo sapiens	60-65
22975350-6	2012	Sulphoraphane was found to down-regulate the expressions of HSP70, 90 and HSF1, though the effect on HSP27 was not pronounced.	sulforaphane	0-13	heat shock transcription factor 1	Homo sapiens	74-78
22643862-5	2012	In further studies, it was demonstrated that R,S-sulforaphane could both prevent the interaction of and displace already bound benzo[a]pyrene from the Ah receptor, but no concentration dependency was observed with respect to the isothiocyanate.	sulforaphane	45-61	aryl hydrocarbon receptor	Rattus norvegicus	151-162
22982310-6	2012	Sulforaphane promoted lipolysis and increased both HSL gene expression and HSL activation.	sulforaphane	0-12	lipase E, hormone sensitive type	Homo sapiens	51-54
22982310-6	2012	Sulforaphane promoted lipolysis and increased both HSL gene expression and HSL activation.	sulforaphane	0-12	lipase E, hormone sensitive type	Homo sapiens	75-78
22982310-7	2012	Sulforaphane suppressed AMPK phosphorylation at Thr-172 in a dose-dependent manner, which was associated with a decrease in HSL phosphorylation at Ser-565, enhancing the phosphorylation of HSL Ser-563.	sulforaphane	0-12	lipase E, hormone sensitive type	Homo sapiens	124-127
22982310-7	2012	Sulforaphane suppressed AMPK phosphorylation at Thr-172 in a dose-dependent manner, which was associated with a decrease in HSL phosphorylation at Ser-565, enhancing the phosphorylation of HSL Ser-563.	sulforaphane	0-12	lipase E, hormone sensitive type	Homo sapiens	189-192
22643862-2	2012	It is demonstrated in this paper that the isothiocyanates R,S-sulforaphane and erucin are non-competitive antagonists of the aryl hydrocarbon (Ah) receptor.	sulforaphane	58-74	aryl hydrocarbon receptor	Rattus norvegicus	125-155
22643862-7	2012	Of the two isomers of R,S-sulforaphane, the naturally occurring R-isomer was more effective than the S-isomer in antagonizing the activation of the Ah receptor by benzo[a]pyrene.	sulforaphane	22-38	aryl hydrocarbon receptor	Rattus norvegicus	148-159
22931430-5	2012	We report the crystallographic structures of human MIF bound to phenethylisothiocyanate and to l-sulforaphane (dietary isothiocyanates derived from watercress and broccoli, respectively) and correlate structural features of these two isothiocyanates with their second-order rate constants for MIF inactivation.	sulforaphane	95-109	macrophage migration inhibitory factor	Homo sapiens	51-54
22640941-8	2012	However, human GSTs in general do not appear to be extensively induced by SFN, and GSTM1 - the only human GST with measurable catalytic activity toward aflatoxin B(1)-8,9-epoxide (AFBO; the genotoxic metabolite of AFB), does not appear to be induced by SFN, at least in human hepatocytes, even though its expression in human liver cells does appear to offer considerable protection against AFB-DNA damage.	sulforaphane	253-256	glutathione S-transferase mu 1	Homo sapiens	83-88
22640941-12	2012	SFN has been shown to protect animals from AFB-induced tumors, to reduce AFB biomarkers in humans in vivo and to reduce efficiently AFB adduct formation in human hepatocytes, although it appears that this protective effect is the result of repression of human hepatic CYP3A4 expression, rather than induction of protective GSTs, at least in human hepatocytes.	sulforaphane	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	268-274
22640941-12	2012	SFN has been shown to protect animals from AFB-induced tumors, to reduce AFB biomarkers in humans in vivo and to reduce efficiently AFB adduct formation in human hepatocytes, although it appears that this protective effect is the result of repression of human hepatic CYP3A4 expression, rather than induction of protective GSTs, at least in human hepatocytes.	sulforaphane	0-3	glutathione S-transferase mu 1	Homo sapiens	323-327
22931102-1	2012	This study assesses the pharmacokinetics (PK) and pharmacodynamics (PD) of Nrf2-mediated increased expression of phase II drug metabolizing enzymes (DME) and antioxidant enzymes which represents an important component of cancer chemoprevention in rat lymphocytes following intravenous (iv) administration of an anticancer phytochemical sulforaphane (SFN).	sulforaphane	336-348	NFE2 like bZIP transcription factor 2	Rattus norvegicus	75-79
22931102-1	2012	This study assesses the pharmacokinetics (PK) and pharmacodynamics (PD) of Nrf2-mediated increased expression of phase II drug metabolizing enzymes (DME) and antioxidant enzymes which represents an important component of cancer chemoprevention in rat lymphocytes following intravenous (iv) administration of an anticancer phytochemical sulforaphane (SFN).	sulforaphane	350-353	NFE2 like bZIP transcription factor 2	Rattus norvegicus	75-79
22931102-12	2012	Our present study shows that SFN could induce Nrf2-mediated phase II DME/antioxidant mRNA expression for NQO1, GSTT1, Nrf2, GPx, Maf, and HO-1 in rat lymphocytes after iv administration, suggesting that Nrf2-mediated mRNA expression in lymphocytes may serve as surrogate biomarkers.	sulforaphane	29-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-50
22931102-12	2012	Our present study shows that SFN could induce Nrf2-mediated phase II DME/antioxidant mRNA expression for NQO1, GSTT1, Nrf2, GPx, Maf, and HO-1 in rat lymphocytes after iv administration, suggesting that Nrf2-mediated mRNA expression in lymphocytes may serve as surrogate biomarkers.	sulforaphane	29-32	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	105-109
22931102-12	2012	Our present study shows that SFN could induce Nrf2-mediated phase II DME/antioxidant mRNA expression for NQO1, GSTT1, Nrf2, GPx, Maf, and HO-1 in rat lymphocytes after iv administration, suggesting that Nrf2-mediated mRNA expression in lymphocytes may serve as surrogate biomarkers.	sulforaphane	29-32	glutathione S-transferase theta 1	Rattus norvegicus	111-116
22931102-12	2012	Our present study shows that SFN could induce Nrf2-mediated phase II DME/antioxidant mRNA expression for NQO1, GSTT1, Nrf2, GPx, Maf, and HO-1 in rat lymphocytes after iv administration, suggesting that Nrf2-mediated mRNA expression in lymphocytes may serve as surrogate biomarkers.	sulforaphane	29-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
22931102-12	2012	Our present study shows that SFN could induce Nrf2-mediated phase II DME/antioxidant mRNA expression for NQO1, GSTT1, Nrf2, GPx, Maf, and HO-1 in rat lymphocytes after iv administration, suggesting that Nrf2-mediated mRNA expression in lymphocytes may serve as surrogate biomarkers.	sulforaphane	29-32	MAF bZIP transcription factor	Rattus norvegicus	129-132
22931102-12	2012	Our present study shows that SFN could induce Nrf2-mediated phase II DME/antioxidant mRNA expression for NQO1, GSTT1, Nrf2, GPx, Maf, and HO-1 in rat lymphocytes after iv administration, suggesting that Nrf2-mediated mRNA expression in lymphocytes may serve as surrogate biomarkers.	sulforaphane	29-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	118-122
22931102-13	2012	The PK-PD IDR model simultaneously linking the plasma concentrations of SFN and the PD response of lymphocyte mRNA expression is valuable for quantitating Nrf2-mediated effects of SFN.	sulforaphane	72-75	NFE2 like bZIP transcription factor 2	Rattus norvegicus	155-159
22978402-0	2012	Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
22776248-0	2012	Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.	sulforaphane	12-24	carboxylesterase 1	Homo sapiens	73-91
22776248-5	2012	Cells over-expressing Keap1 were treated with TNBS or SFN and the formation of disulfide bonds among Keap1 molecules were determined.	sulforaphane	54-57	kelch like ECH associated protein 1	Homo sapiens	22-27
22978402-12	2012	The aortic protection from diabetes by SFN was associated with the up-regulation of Nrf2 and its downstream antioxidants.	sulforaphane	39-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
22978402-10	2012	SFN completely prevented these diabetic pathogenic changes and also significantly up-regulated the expression of Nrf2 and its down-stream antioxidants.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-117
22749810-4	2012	The Nrf2 activators, tert-butylhydroquinone (t-BHQ) and sulforaphane (SFN), up-regulated Sesn2 expression in a dose- and time-dependent manner in hepatocytes.	sulforaphane	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
22925072-5	2012	SUL, PEITC, and BITC significantly inhibited apoptosis in the left ventricle by increasing the Bcl-2/Bax ratio compared with LP-BM5-infected mice.	sulforaphane	0-3	B cell leukemia/lymphoma 2	Mus musculus	95-100
22925072-5	2012	SUL, PEITC, and BITC significantly inhibited apoptosis in the left ventricle by increasing the Bcl-2/Bax ratio compared with LP-BM5-infected mice.	sulforaphane	0-3	BCL2-associated X protein	Mus musculus	101-104
22925072-6	2012	In addition, SUL and PEITC suppressed inducible nitric oxide synthase (iNOS) expression at both the mRNA and protein levels in the left ventricle of heart tissue infected with the LP-BM5 retrovirus by inactivating cytoplasmic nuclear factor kappaB (NF-kappaB).	sulforaphane	13-16	nitric oxide synthase 2, inducible	Mus musculus	71-75
22925072-6	2012	In addition, SUL and PEITC suppressed inducible nitric oxide synthase (iNOS) expression at both the mRNA and protein levels in the left ventricle of heart tissue infected with the LP-BM5 retrovirus by inactivating cytoplasmic nuclear factor kappaB (NF-kappaB).	sulforaphane	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	249-258
22683604-9	2012	Sulforaphane enhanced NQO1 protein (10.5-fold) and blunted triglyceride and FABP4 accumulation.	sulforaphane	0-12	NAD(P)H dehydrogenase, quinone 1	Mus musculus	22-26
22683604-9	2012	Sulforaphane enhanced NQO1 protein (10.5-fold) and blunted triglyceride and FABP4 accumulation.	sulforaphane	0-12	fatty acid binding protein 4, adipocyte	Mus musculus	76-81
22749810-4	2012	The Nrf2 activators, tert-butylhydroquinone (t-BHQ) and sulforaphane (SFN), up-regulated Sesn2 expression in a dose- and time-dependent manner in hepatocytes.	sulforaphane	56-68	sestrin 2	Homo sapiens	89-94
22749810-4	2012	The Nrf2 activators, tert-butylhydroquinone (t-BHQ) and sulforaphane (SFN), up-regulated Sesn2 expression in a dose- and time-dependent manner in hepatocytes.	sulforaphane	70-73	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
22749810-4	2012	The Nrf2 activators, tert-butylhydroquinone (t-BHQ) and sulforaphane (SFN), up-regulated Sesn2 expression in a dose- and time-dependent manner in hepatocytes.	sulforaphane	70-73	sestrin 2	Homo sapiens	89-94
22581777-3	2012	To identify human NRF2-regulated genes, we conducted chromatin immunoprecipitation (ChIP)-sequencing experiments in lymphoid cells treated with the dietary isothiocyanate, sulforaphane (SFN) and carried out follow-up biological experiments on candidates.	sulforaphane	172-184	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
22367278-9	2012	Sulforaphane, an activator of Nrf2, suppressed the pathological states and oxidative stress in the livers.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
22581777-3	2012	To identify human NRF2-regulated genes, we conducted chromatin immunoprecipitation (ChIP)-sequencing experiments in lymphoid cells treated with the dietary isothiocyanate, sulforaphane (SFN) and carried out follow-up biological experiments on candidates.	sulforaphane	186-189	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
22758632-6	2012	The model further revealed a GPx2-independent decrease in tumor development by selenium (Se) and detrimental effects of the Nrf2-activator sulforaphane in moderate Se deficiency.	sulforaphane	139-151	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
25683399-0	2012	Synergy between sulforaphane and selenium in the up-regulation of thioredoxin reductase and protection against hydrogen peroxide-induced cell death in human hepatocytes.	sulforaphane	16-28	peroxiredoxin 5	Homo sapiens	66-87
25683399-2	2012	It has been previously shown that sulforaphane and selenium have a synergistic effect on the upregulation of thioredoxin reductase-1 (TrxR-1) in human hepatoma HepG2 cells.	sulforaphane	34-46	thioredoxin reductase 1	Homo sapiens	109-132
25683399-2	2012	It has been previously shown that sulforaphane and selenium have a synergistic effect on the upregulation of thioredoxin reductase-1 (TrxR-1) in human hepatoma HepG2 cells.	sulforaphane	34-46	thioredoxin reductase 1	Homo sapiens	134-140
25683399-3	2012	In this paper, further evidence is presented to show that sulforaphane and selenium synergistically induce TrxR-1 expression in immortalised human hepatocytes.	sulforaphane	58-70	thioredoxin reductase 1	Homo sapiens	107-113
25683399-4	2012	Sulforaphane was found to be more toxic toward hepatocytes than HepG2 cells with IC50=25.1 and 56.4 muM, respectively.	sulforaphane	0-12	latexin	Homo sapiens	100-103
25683399-6	2012	Using siRNA to knock down TrxR-1 or Nrf2, sulforaphane (5 muM)-protected cell viability was reduced from 73% to 46% and 34%, respectively, suggesting that TrxR-1 is an important enzyme in protection against hydrogen peroxide-induced cell death.	sulforaphane	42-54	thioredoxin reductase 1	Homo sapiens	26-32
25683399-6	2012	Using siRNA to knock down TrxR-1 or Nrf2, sulforaphane (5 muM)-protected cell viability was reduced from 73% to 46% and 34%, respectively, suggesting that TrxR-1 is an important enzyme in protection against hydrogen peroxide-induced cell death.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
25683399-6	2012	Using siRNA to knock down TrxR-1 or Nrf2, sulforaphane (5 muM)-protected cell viability was reduced from 73% to 46% and 34%, respectively, suggesting that TrxR-1 is an important enzyme in protection against hydrogen peroxide-induced cell death.	sulforaphane	42-54	latexin	Homo sapiens	58-61
25683399-6	2012	Using siRNA to knock down TrxR-1 or Nrf2, sulforaphane (5 muM)-protected cell viability was reduced from 73% to 46% and 34%, respectively, suggesting that TrxR-1 is an important enzyme in protection against hydrogen peroxide-induced cell death.	sulforaphane	42-54	thioredoxin reductase 1	Homo sapiens	155-161
25683399-7	2012	Sulforaphane-induced TrxR-1 expression was positively associated with significant levels of Nrf2 translocation into the nucleus, but co-treatment with selenium showed no significant increase in Nrf2 translocation.	sulforaphane	0-12	thioredoxin reductase 1	Homo sapiens	21-27
25683399-7	2012	Sulforaphane-induced TrxR-1 expression was positively associated with significant levels of Nrf2 translocation into the nucleus, but co-treatment with selenium showed no significant increase in Nrf2 translocation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
22708678-0	2012	Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/beta-catenin function.	sulforaphane	0-12	catenin beta 1	Homo sapiens	128-140
25683399-9	2012	However, blocking ERK and JNK signalling pathways decreased sulforaphane-induced TrxR-1 mRNA by about 20%; whereas blocking p38 and PI3K/AKT increased TrxR-1 transcription.	sulforaphane	60-72	mitogen-activated protein kinase 1	Homo sapiens	18-21
25683399-9	2012	However, blocking ERK and JNK signalling pathways decreased sulforaphane-induced TrxR-1 mRNA by about 20%; whereas blocking p38 and PI3K/AKT increased TrxR-1 transcription.	sulforaphane	60-72	mitogen-activated protein kinase 8	Homo sapiens	26-29
25683399-9	2012	However, blocking ERK and JNK signalling pathways decreased sulforaphane-induced TrxR-1 mRNA by about 20%; whereas blocking p38 and PI3K/AKT increased TrxR-1 transcription.	sulforaphane	60-72	thioredoxin reductase 1	Homo sapiens	81-87
25683399-10	2012	In summary, a combination of sulforaphane and selenium resulted in a synergistic upregulation of TrxR-1 that contributed to the enhanced protection against free radical-mediated oxidative damage in human hepatocytes.	sulforaphane	29-41	thioredoxin reductase 1	Homo sapiens	97-103
22565590-0	2012	Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway.	sulforaphane	10-22	mitogen-activated protein kinase kinase 7	Homo sapiens	122-125
22565590-0	2012	Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway.	sulforaphane	10-22	mitogen-activated protein kinase 1	Homo sapiens	126-129
22552270-0	2012	Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress             by sulforaphane through the activation of Nrf2 nuclear translocation.	sulforaphane	84-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	123-127
21129940-4	2012	Sulforaphane is considered an indirect antioxidant; this compound is able to induce many cytoprotective proteins, including antioxidant enzymes, through the Nrf2-antioxidant response element pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
21129940-5	2012	Heme oxygenase-1, NAD(P)H: quinone oxidoreductase, glutathione-S-transferase, gamma-glutamyl cysteine ligase, and glutathione reductase are among the cytoprotective proteins induced by sulforaphane.	sulforaphane	185-197	heme oxygenase 1	Homo sapiens	0-16
21129940-5	2012	Heme oxygenase-1, NAD(P)H: quinone oxidoreductase, glutathione-S-transferase, gamma-glutamyl cysteine ligase, and glutathione reductase are among the cytoprotective proteins induced by sulforaphane.	sulforaphane	185-197	crystallin zeta	Homo sapiens	27-49
21129940-5	2012	Heme oxygenase-1, NAD(P)H: quinone oxidoreductase, glutathione-S-transferase, gamma-glutamyl cysteine ligase, and glutathione reductase are among the cytoprotective proteins induced by sulforaphane.	sulforaphane	185-197	glutathione S-transferase kappa 1	Homo sapiens	51-76
21129940-5	2012	Heme oxygenase-1, NAD(P)H: quinone oxidoreductase, glutathione-S-transferase, gamma-glutamyl cysteine ligase, and glutathione reductase are among the cytoprotective proteins induced by sulforaphane.	sulforaphane	185-197	glutathione-disulfide reductase	Homo sapiens	114-135
22552270-7	2012	We also found that transfection with NF-E2-related             factor-2 (Nrf2) siRNA reversed the inhibitory effects of SF on 6-OHDA-induced             ER stress responses.	sulforaphane	120-122	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-71
22552270-7	2012	We also found that transfection with NF-E2-related             factor-2 (Nrf2) siRNA reversed the inhibitory effects of SF on 6-OHDA-induced             ER stress responses.	sulforaphane	120-122	NFE2 like bZIP transcription factor 2	Rattus norvegicus	73-77
22552270-8	2012	In conclusion, our results show that SF can prevent ER stress             response induced by 6-OHDA through the activation of Nrf2.	sulforaphane	37-39	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
26105441-12	2012	In particular, activating of Nrf2 via sulforaphane, may have therapeutic potential in preeclampsia.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
22282047-11	2012	Additionally, sulforaphane modestly decreased the phosphorylation of ERK1/2 and Akt.	sulforaphane	14-26	thymoma viral proto-oncogene 1	Mus musculus	80-83
22282047-12	2012	Our results indicate that the inhibition of early-stage adipocyte differentiation by sulforaphane may be associated with cell cycle arrest at the G(0)/G(1) phase through upregulation of p27 expression.	sulforaphane	85-97	cyclin-dependent kinase inhibitor 1B	Mus musculus	186-189
22282047-5	2012	The expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), major transcription factors for adipocyte differentiation, was significantly reduced by sulforaphane.	sulforaphane	222-234	peroxisome proliferator activated receptor gamma	Mus musculus	18-66
22282047-5	2012	The expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), major transcription factors for adipocyte differentiation, was significantly reduced by sulforaphane.	sulforaphane	222-234	peroxisome proliferator activated receptor gamma	Mus musculus	68-77
22282047-5	2012	The expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), major transcription factors for adipocyte differentiation, was significantly reduced by sulforaphane.	sulforaphane	222-234	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	83-119
22282047-5	2012	The expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha (C/EBPalpha), major transcription factors for adipocyte differentiation, was significantly reduced by sulforaphane.	sulforaphane	222-234	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	121-131
22282047-7	2012	Thus, the expression of C/EBPbeta, an early-stage biomarker of adipogenesis, decreased in a concentration-dependent manner when the adipocytes were exposed to sulforaphane (0, 5, 10, and 20 micromol/l).	sulforaphane	159-171	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	24-33
22282047-10	2012	Sulforaphane arrested the cell cycle at the G(0)/G(1) phase, increased p27 expression, and decreased retinoblastoma (Rb) phosphorylation.	sulforaphane	0-12	cyclin-dependent kinase inhibitor 1B	Mus musculus	71-74
22282047-11	2012	Additionally, sulforaphane modestly decreased the phosphorylation of ERK1/2 and Akt.	sulforaphane	14-26	mitogen-activated protein kinase 3	Mus musculus	69-75
22200890-11	2012	In addition, the lowering of DA levels and DOPAC as well as DAT immunoreactivity in the striatum, usually seen after repeated administration of METH, was significantly attenuated by both pretreatment and the subsequent administration of SFN.	sulforaphane	237-240	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	60-63
22332123-10	2012	At a concentration as low as 5 muM, SFN completely inhibited mPGES, COX-2 and iNOS at the mRNA and protein levels, and proteoglycan and type II collagen degradation product release in explant culture.	sulforaphane	36-39	latexin	Homo sapiens	31-34
21382956-7	2012	Furthermore, SFN and eugenol combinations at synergistic dose significantly downregulated the expression of Bcl-2, COX-2 and IL-beta but not the antagonistic combinations.	sulforaphane	13-16	BCL2 apoptosis regulator	Homo sapiens	108-113
21382956-7	2012	Furthermore, SFN and eugenol combinations at synergistic dose significantly downregulated the expression of Bcl-2, COX-2 and IL-beta but not the antagonistic combinations.	sulforaphane	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
22449404-9	2012	When hippocampal slices were treated with sulforaphane, the expression and activity of GST were increased.	sulforaphane	42-54	hematopoietic prostaglandin D synthase	Rattus norvegicus	87-90
22332123-10	2012	At a concentration as low as 5 muM, SFN completely inhibited mPGES, COX-2 and iNOS at the mRNA and protein levels, and proteoglycan and type II collagen degradation product release in explant culture.	sulforaphane	36-39	prostaglandin E synthase	Mus musculus	61-66
22332123-10	2012	At a concentration as low as 5 muM, SFN completely inhibited mPGES, COX-2 and iNOS at the mRNA and protein levels, and proteoglycan and type II collagen degradation product release in explant culture.	sulforaphane	36-39	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	68-73
22332123-10	2012	At a concentration as low as 5 muM, SFN completely inhibited mPGES, COX-2 and iNOS at the mRNA and protein levels, and proteoglycan and type II collagen degradation product release in explant culture.	sulforaphane	36-39	nitric oxide synthase 2	Homo sapiens	78-82
21465338-1	2012	Brassica vegetables are attracting a great deal of attention as healthy foods because of the fact that they contain substantial amounts of secondary metabolite glucosinolates that are converted into isothiocyanates, such as sulforaphane [(-)1-isothiocyanato-4R-(methylsulfinyl)-butane] (R-SFN), through the actions of chopping or chewing the vegetables.	sulforaphane	224-236	RNA exonuclease 2	Homo sapiens	289-292
22578879-2	2012	Interest in these unique phytochemicals escalated following the discovery that sulforaphane, an isothiocyanate from broccoli, potently induces mammalian cytoprotective proteins through the Keap1-Nrf2-ARE pathway.	sulforaphane	79-91	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
22427654-0	2012	Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.	sulforaphane	0-12	H3 histone pseudogene 16	Homo sapiens	26-29
22427654-0	2012	Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-34
22427654-0	2012	Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.	sulforaphane	0-12	tumor protein p53	Homo sapiens	90-93
22427654-0	2012	Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent.	sulforaphane	0-12	tumor protein p53	Homo sapiens	131-134
22617456-0	2012	Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma.	sulforaphane	0-12	heart and neural crest derivatives expressed 2	Mus musculus	26-29
22617456-0	2012	Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma.	sulforaphane	0-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	49-58
22617456-3	2012	In this study, we attempt to determine whether sulforaphane regulates the inflammatory response in an ovalbumin (OVA)-induced murine asthma model.	sulforaphane	47-59	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	102-111
22617456-6	2012	Additionally, sulforaphane suppressed the increase in the levels of SOCS-3 and GATA-3 and IL-4 expression in the OVA-challenged mice.	sulforaphane	14-26	suppressor of cytokine signaling 3	Mus musculus	68-74
22617456-6	2012	Additionally, sulforaphane suppressed the increase in the levels of SOCS-3 and GATA-3 and IL-4 expression in the OVA-challenged mice.	sulforaphane	14-26	GATA binding protein 3	Mus musculus	79-85
22617456-6	2012	Additionally, sulforaphane suppressed the increase in the levels of SOCS-3 and GATA-3 and IL-4 expression in the OVA-challenged mice.	sulforaphane	14-26	interleukin 4	Mus musculus	90-94
22617456-7	2012	Collectively, our results demonstrate that sulforaphane regulates Th2 immune responses.	sulforaphane	43-55	heart and neural crest derivatives expressed 2	Mus musculus	66-69
22617456-8	2012	This sutdy provides novel insights into the regulatory role of sulforaphane in allergen-induced Th2 inflammation and airway responses, which indicates its therapeutic potential for asthma and other allergic diseases.	sulforaphane	63-75	heart and neural crest derivatives expressed 2	Mus musculus	96-99
22652377-0	2012	Sulforaphane retards the growth of UM-UC-3 xenographs, induces apoptosis, and reduces survivin in athymic mice.	sulforaphane	0-12	baculoviral IAP repeat-containing 5	Mus musculus	86-94
22652377-11	2012	Sulforaphane extract induced caspase 3 and cytochrome c expression but reduced the expression of survivin.	sulforaphane	0-12	caspase 3	Mus musculus	29-38
22652377-11	2012	Sulforaphane extract induced caspase 3 and cytochrome c expression but reduced the expression of survivin.	sulforaphane	0-12	baculoviral IAP repeat-containing 5	Mus musculus	97-105
22578879-2	2012	Interest in these unique phytochemicals escalated following the discovery that sulforaphane, an isothiocyanate from broccoli, potently induces mammalian cytoprotective proteins through the Keap1-Nrf2-ARE pathway.	sulforaphane	79-91	kelch like ECH associated protein 1	Homo sapiens	189-194
22559738-4	2012	SFN- induced UGT1A expression may have resulted from Nrf2 nuclear translocation or activation.	sulforaphane	0-3	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	13-18
22559738-4	2012	SFN- induced UGT1A expression may have resulted from Nrf2 nuclear translocation or activation.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	53-57
22559738-6	2012	Taken together, these results demonstrated the chemopreventive effects of SFN on human colon cancer Caco-2 cells may have been partly attributed to Nrf2-mediated UGT1A induction and apoptosis induction, and our studies provided theoretic and experimental basis for clinical application of SFN to human colon cancer prevention.	sulforaphane	74-77	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
22559738-6	2012	Taken together, these results demonstrated the chemopreventive effects of SFN on human colon cancer Caco-2 cells may have been partly attributed to Nrf2-mediated UGT1A induction and apoptosis induction, and our studies provided theoretic and experimental basis for clinical application of SFN to human colon cancer prevention.	sulforaphane	74-77	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	162-167
22559738-6	2012	Taken together, these results demonstrated the chemopreventive effects of SFN on human colon cancer Caco-2 cells may have been partly attributed to Nrf2-mediated UGT1A induction and apoptosis induction, and our studies provided theoretic and experimental basis for clinical application of SFN to human colon cancer prevention.	sulforaphane	289-292	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
21806470-6	2012	Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination.	sulforaphane	31-43	tumor necrosis factor	Rattus norvegicus	291-318
22269145-9	2012	The presence of the pregnane X receptor antagonist sulforaphane blocked the ETR-mediated increase in CYP3A4 mRNA expression.	sulforaphane	51-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
21806470-6	2012	Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination.	sulforaphane	31-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	61-65
21806470-6	2012	Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination.	sulforaphane	31-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119
21806470-6	2012	Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination.	sulforaphane	31-43	tumor necrosis factor	Rattus norvegicus	320-329
21806470-6	2012	Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination.	sulforaphane	31-43	interleukin 1 beta	Rattus norvegicus	258-275
21806470-7	2012	These results show that activation of the Nrf2/ARE pathway following SCI is neuroprotective and that sulforaphane is a viable compound for neurotherapeutic intervention in blocking pathomechanisms following SCI.	sulforaphane	101-113	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
21806470-6	2012	Treatment of injured rats with sulforaphane, an activator of Nrf2/ARE signaling, significantly increased levels of Nrf2 and glutamate-cysteine ligase (GCL), a rate-limiting enzyme for synthesis of glutathione, and decreased levels of inflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) thus leading to a reduction in contusion volume and improvement in coordination.	sulforaphane	31-43	interleukin 1 beta	Rattus norvegicus	277-285
22424098-9	2012	Furthermore, sulforaphane suppressed hypoxia- and CoCl(2)-induced upregulation of TLR4 mRNA and protein by inhibiting PI3K/Akt activation and the subsequent nuclear accumulation and transcriptional activation of HIF-1alpha.	sulforaphane	13-25	toll like receptor 4	Homo sapiens	82-86
22424098-9	2012	Furthermore, sulforaphane suppressed hypoxia- and CoCl(2)-induced upregulation of TLR4 mRNA and protein by inhibiting PI3K/Akt activation and the subsequent nuclear accumulation and transcriptional activation of HIF-1alpha.	sulforaphane	13-25	AKT serine/threonine kinase 1	Homo sapiens	123-126
22424098-9	2012	Furthermore, sulforaphane suppressed hypoxia- and CoCl(2)-induced upregulation of TLR4 mRNA and protein by inhibiting PI3K/Akt activation and the subsequent nuclear accumulation and transcriptional activation of HIF-1alpha.	sulforaphane	13-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	212-222
22180572-4	2012	Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications.	sulforaphane	45-57	glutathione peroxidase 2	Mus musculus	6-10
22180572-4	2012	Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications.	sulforaphane	59-62	glutathione peroxidase 2	Mus musculus	6-10
22180572-8	2012	NAD(P)H:quinone oxidoreductases, thioredoxin reductases and glutathione-S-transferases were upregulated in the ileum and/or colon by SFN, as was GPx2 in WT mice.	sulforaphane	133-136	glutathione peroxidase 2	Mus musculus	145-149
22180572-4	2012	Since GPx2 is induced by the chemopreventive sulforaphane (SFN) via the nuclear factor E2-related factor 2 (Nrf2)/Keap1 system, the susceptibility of GPx2-KO and wild-type (WT) mice to azoxymethane and dextran sulfate sodium (AOM/DSS)-induced colon carcinogenesis was tested under different selenium states and SFN applications.	sulforaphane	59-62	kelch-like ECH-associated protein 1	Mus musculus	114-119
20880684-0	2012	Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells.	sulforaphane	0-13	intercellular adhesion molecule 1	Homo sapiens	43-76
20880684-0	2012	Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells.	sulforaphane	0-13	vascular cell adhesion molecule 1	Homo sapiens	81-114
20880684-0	2012	Sulphoraphane inhibited the expressions of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 through MyD88-dependent toll-like receptor-4 pathway in cultured endothelial cells.	sulforaphane	0-13	MYD88 innate immune signal transduction adaptor	Homo sapiens	123-128
20880684-8	2012	The results demonstrated that sulphoraphane significantly suppresses the expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 stimulated by lipopolysaccharide (LPS) both at the transcriptional and translational levels.	sulforaphane	30-43	intercellular adhesion molecule 1	Homo sapiens	87-127
20880684-8	2012	The results demonstrated that sulphoraphane significantly suppresses the expression of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 stimulated by lipopolysaccharide (LPS) both at the transcriptional and translational levels.	sulforaphane	30-43	vascular cell adhesion molecule 1	Homo sapiens	132-172
20880684-10	2012	Sulphoraphane decreased the phosphorylation of extra-cellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), while further blockade and activation using individually specific agents confirm that p38 MAPK and JNK are mainly involved.	sulforaphane	0-13	mitogen-activated protein kinase 8	Homo sapiens	93-114
20880684-10	2012	Sulphoraphane decreased the phosphorylation of extra-cellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), while further blockade and activation using individually specific agents confirm that p38 MAPK and JNK are mainly involved.	sulforaphane	0-13	mitogen-activated protein kinase 8	Homo sapiens	116-119
20880684-10	2012	Sulphoraphane decreased the phosphorylation of extra-cellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), while further blockade and activation using individually specific agents confirm that p38 MAPK and JNK are mainly involved.	sulforaphane	0-13	mitogen-activated protein kinase 14	Homo sapiens	125-161
20880684-10	2012	Sulphoraphane decreased the phosphorylation of extra-cellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), while further blockade and activation using individually specific agents confirm that p38 MAPK and JNK are mainly involved.	sulforaphane	0-13	mitogen-activated protein kinase 14	Homo sapiens	125-128
20880684-10	2012	Sulphoraphane decreased the phosphorylation of extra-cellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK), while further blockade and activation using individually specific agents confirm that p38 MAPK and JNK are mainly involved.	sulforaphane	0-13	mitogen-activated protein kinase 8	Homo sapiens	269-272
20880684-11	2012	Interestingly, sulphoraphane down-regulated Toll-like receptor (TLR)-4, a receptor of LPS located on the membrane.	sulforaphane	15-28	toll like receptor 4	Homo sapiens	44-70
20880684-14	2012	Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-kB translocation and the subsequent expression of adhesion molecules.	sulforaphane	0-13	toll like receptor 4	Homo sapiens	25-30
20880684-14	2012	Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-kB translocation and the subsequent expression of adhesion molecules.	sulforaphane	0-13	MYD88 innate immune signal transduction adaptor	Homo sapiens	43-48
20880684-14	2012	Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-kB translocation and the subsequent expression of adhesion molecules.	sulforaphane	0-13	mitogen-activated protein kinase 14	Homo sapiens	80-83
20880684-14	2012	Sulphoraphane suppressed TLR-4 followed by MyD88 and downstream factors such as p38 MAPK and JNK, ultimately blocking NF-kB translocation and the subsequent expression of adhesion molecules.	sulforaphane	0-13	mitogen-activated protein kinase 8	Homo sapiens	93-96
22155163-6	2012	Sulforaphane also suppressed TNF-alpha-induced production of intracellular reactive oxygen species (ROS) and activation of p38, ERK and JNK.	sulforaphane	0-12	mitogen-activated protein kinase 1	Mus musculus	128-131
22155163-6	2012	Sulforaphane also suppressed TNF-alpha-induced production of intracellular reactive oxygen species (ROS) and activation of p38, ERK and JNK.	sulforaphane	0-12	mitogen-activated protein kinase 8	Mus musculus	136-139
22155163-0	2012	Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-alpha-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-kappaB and AP-1 signaling pathways.	sulforaphane	0-12	tumor necrosis factor	Mus musculus	67-76
22155163-4	2012	In the present study, we investigate the effect of sulforaphane on the expression of VCAM-1 induced by TNF-alpha in cultured mouse vascular smooth muscle cell lines.	sulforaphane	51-63	vascular cell adhesion molecule 1	Mus musculus	85-91
22155163-4	2012	In the present study, we investigate the effect of sulforaphane on the expression of VCAM-1 induced by TNF-alpha in cultured mouse vascular smooth muscle cell lines.	sulforaphane	51-63	tumor necrosis factor	Mus musculus	103-112
22155163-7	2012	Furthermore, sulforaphane inhibited NK-kappaB and AP-1 activation induced by TNF-alpha.	sulforaphane	13-25	tumor necrosis factor	Mus musculus	77-86
22155163-8	2012	Sulforaphane inhibited TNF-alpha-induced IotakappaBeta kinase activation, subsequent degradation of IotakappaBetaalpha and nuclear translocation of p65 NF-kappaB and decreased c-Jun and c-Fos protein level.	sulforaphane	0-12	tumor necrosis factor	Mus musculus	23-32
22155163-8	2012	Sulforaphane inhibited TNF-alpha-induced IotakappaBeta kinase activation, subsequent degradation of IotakappaBetaalpha and nuclear translocation of p65 NF-kappaB and decreased c-Jun and c-Fos protein level.	sulforaphane	0-12	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	148-161
22155163-8	2012	Sulforaphane inhibited TNF-alpha-induced IotakappaBeta kinase activation, subsequent degradation of IotakappaBetaalpha and nuclear translocation of p65 NF-kappaB and decreased c-Jun and c-Fos protein level.	sulforaphane	0-12	jun proto-oncogene	Mus musculus	176-181
22155163-8	2012	Sulforaphane inhibited TNF-alpha-induced IotakappaBeta kinase activation, subsequent degradation of IotakappaBetaalpha and nuclear translocation of p65 NF-kappaB and decreased c-Jun and c-Fos protein level.	sulforaphane	0-12	FBJ osteosarcoma oncogene	Mus musculus	186-191
22155163-5	2012	Pretreatment of VSMCs for 2h with sulforaphane (1-5mug/ml) dose-dependently inhibited TNF-alpha-induced adhesion of THP-1 monocytic cells and protein expression of VCAM-1.	sulforaphane	34-46	tumor necrosis factor	Homo sapiens	86-95
22155163-9	2012	This study suggests that sulforaphane inhibits the adhesive capacity of VSMC and downregulates the TNF-alpha-mediated induction of VCAM-1 in VSMC by inhibiting the MAPK, NF-kappaB and AP-1 signaling pathways and intracellular ROS production.	sulforaphane	25-37	tumor necrosis factor	Mus musculus	99-108
22155163-5	2012	Pretreatment of VSMCs for 2h with sulforaphane (1-5mug/ml) dose-dependently inhibited TNF-alpha-induced adhesion of THP-1 monocytic cells and protein expression of VCAM-1.	sulforaphane	34-46	vascular cell adhesion molecule 1	Homo sapiens	164-170
22155163-6	2012	Sulforaphane also suppressed TNF-alpha-induced production of intracellular reactive oxygen species (ROS) and activation of p38, ERK and JNK.	sulforaphane	0-12	tumor necrosis factor	Mus musculus	29-38
22155163-9	2012	This study suggests that sulforaphane inhibits the adhesive capacity of VSMC and downregulates the TNF-alpha-mediated induction of VCAM-1 in VSMC by inhibiting the MAPK, NF-kappaB and AP-1 signaling pathways and intracellular ROS production.	sulforaphane	25-37	vascular cell adhesion molecule 1	Mus musculus	131-137
22155163-6	2012	Sulforaphane also suppressed TNF-alpha-induced production of intracellular reactive oxygen species (ROS) and activation of p38, ERK and JNK.	sulforaphane	0-12	mitogen-activated protein kinase 14	Mus musculus	123-126
21745425-2	2012	Nrf2 agonists, such as isothiocyanate sulforaphane (SFN), have been shown to promote chemopreventive effects in skin both in vitro and in vivo.	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
22200816-0	2012	Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity             by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	109-125
22200816-0	2012	Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity             by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	136-139
22200816-3	2012	Sulforaphane (SF),             a naturally occurring isothiocyanate, has been shown to protect against oxidative             stress by inducing the expression of various NF-E2-related factor-2 (Nrf2) responsive             genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	170-192
22200816-3	2012	Sulforaphane (SF),             a naturally occurring isothiocyanate, has been shown to protect against oxidative             stress by inducing the expression of various NF-E2-related factor-2 (Nrf2) responsive             genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	194-198
22200816-3	2012	Sulforaphane (SF),             a naturally occurring isothiocyanate, has been shown to protect against oxidative             stress by inducing the expression of various NF-E2-related factor-2 (Nrf2) responsive             genes.	sulforaphane	14-16	NFE2 like bZIP transcription factor 2	Homo sapiens	170-192
22200816-3	2012	Sulforaphane (SF),             a naturally occurring isothiocyanate, has been shown to protect against oxidative             stress by inducing the expression of various NF-E2-related factor-2 (Nrf2) responsive             genes.	sulforaphane	14-16	NFE2 like bZIP transcription factor 2	Homo sapiens	194-198
21745425-6	2012	Furthermore, SFN-mediated Nrf2 activation and its target gene expression were not further enhanced by the co-application of SFN with cyanidin.	sulforaphane	13-16	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	205-237
22019695-0	2012	Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.	sulforaphane	125-137	AKT serine/threonine kinase 1	Homo sapiens	33-36
22019695-0	2012	Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.	sulforaphane	125-137	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
22019695-0	2012	Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells.	sulforaphane	125-137	heme oxygenase 1	Homo sapiens	94-110
22019695-2	2012	In this study, we investigated Nrf2/HO-1 induction in response to sulforaphane and determined the signaling pathways involved in this process.	sulforaphane	66-78	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
22019695-2	2012	In this study, we investigated Nrf2/HO-1 induction in response to sulforaphane and determined the signaling pathways involved in this process.	sulforaphane	66-78	heme oxygenase 1	Homo sapiens	36-40
22019695-5	2012	Erk1/2 was activated within 1h of sulforaphane addition, whereas Akt phosphorylation was suppressed until the first 8h, and was then maintained at an elevated level until 72h, displaying a biphasic regulatory feature.	sulforaphane	34-46	mitogen-activated protein kinase 3	Homo sapiens	0-6
22019695-5	2012	Erk1/2 was activated within 1h of sulforaphane addition, whereas Akt phosphorylation was suppressed until the first 8h, and was then maintained at an elevated level until 72h, displaying a biphasic regulatory feature.	sulforaphane	34-46	AKT serine/threonine kinase 1	Homo sapiens	65-68
22019695-6	2012	Nrf2 protein levels in both nuclear and whole cell lysates were increased after sulforaphane treatment and were decreased by pretreatment with NAC, actinomycin D and cycloheximide.	sulforaphane	80-92	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
22019695-7	2012	Activation of the Nrf2/HO-1 system after sulforaphane treatment was suppressed by pretreatment with NAC or Ly294002, a PI3K inhibitor.	sulforaphane	41-53	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
22019695-7	2012	Activation of the Nrf2/HO-1 system after sulforaphane treatment was suppressed by pretreatment with NAC or Ly294002, a PI3K inhibitor.	sulforaphane	41-53	heme oxygenase 1	Homo sapiens	23-27
22019695-8	2012	Knockdown of Nrf2 with siRNA decreased cell viability and attenuated sulforaphane-induced HO-1 up-regulation.	sulforaphane	69-81	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
22019695-8	2012	Knockdown of Nrf2 with siRNA decreased cell viability and attenuated sulforaphane-induced HO-1 up-regulation.	sulforaphane	69-81	heme oxygenase 1	Homo sapiens	90-94
22019695-9	2012	Overall, our results indicate that ROS generation and/or activation of PI3K/Akt signaling regulate cell survival and Nrf2-driven HO-1 expression in sulforaphane-treated MSTO-211H cells.	sulforaphane	148-160	AKT serine/threonine kinase 1	Homo sapiens	76-79
22019695-9	2012	Overall, our results indicate that ROS generation and/or activation of PI3K/Akt signaling regulate cell survival and Nrf2-driven HO-1 expression in sulforaphane-treated MSTO-211H cells.	sulforaphane	148-160	NFE2 like bZIP transcription factor 2	Homo sapiens	117-121
22019695-9	2012	Overall, our results indicate that ROS generation and/or activation of PI3K/Akt signaling regulate cell survival and Nrf2-driven HO-1 expression in sulforaphane-treated MSTO-211H cells.	sulforaphane	148-160	heme oxygenase 1	Homo sapiens	129-133
22155056-0	2012	Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-beta/Smad signaling.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	45-67
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	87-109
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	177-193
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	239-243
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	87-109
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	14-17	heme oxygenase 1	Homo sapiens	177-193
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	14-17	NAD(P)H quinone dehydrogenase 1	Homo sapiens	205-237
22155056-1	2012	Sulforaphane (SFN) is a dietary isothiocyanate that exerts chemopreventive effects via NF-E2-related factor 2 (Nrf2)-mediated induction of antioxidant/phase II enzymes, such as heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1).	sulforaphane	14-17	NAD(P)H quinone dehydrogenase 1	Homo sapiens	239-243
22155056-7	2012	However, inhibition of NQO1 activity reversed repression of TGF-beta-stimulated expression of type I collagen by SFN, suggesting the involvement of antioxidant activity of SFN in the suppression of Smad-independent fibrogenic gene expression.	sulforaphane	113-116	NAD(P)H quinone dehydrogenase 1	Homo sapiens	23-27
22155056-7	2012	However, inhibition of NQO1 activity reversed repression of TGF-beta-stimulated expression of type I collagen by SFN, suggesting the involvement of antioxidant activity of SFN in the suppression of Smad-independent fibrogenic gene expression.	sulforaphane	113-116	transforming growth factor beta 1	Homo sapiens	60-68
22155056-9	2012	Collectively, these results show that SFN elicits an antifibrotic effect on hepatic fibrosis through Nrf2-mediated inhibition of the TGF-beta/Smad signaling and subsequent suppression of HSC activation and fibrogenic gene expression.	sulforaphane	38-41	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
22155056-9	2012	Collectively, these results show that SFN elicits an antifibrotic effect on hepatic fibrosis through Nrf2-mediated inhibition of the TGF-beta/Smad signaling and subsequent suppression of HSC activation and fibrogenic gene expression.	sulforaphane	38-41	transforming growth factor beta 1	Homo sapiens	133-141
21956685-7	2012	SFN-treated MDA-MB-231 and MCF-7 cells also exhibited a marked decrease in protein level of peptidyl prolyl isomerase (Pin1), which is implicated in mitochondrial translocation of p66(shc) .	sulforaphane	0-3	DNA polymerase delta 3, accessory subunit	Homo sapiens	180-183
21956685-1	2012	Cancer chemopreventive response to D,L-sulforaphane (SFN), a synthetic racemic analogue of broccoli constituent L-sulforaphane, is partly attributable to apoptosis induction, but the mechanism of cell death is not fully understood.	sulforaphane	53-56	RNA exonuclease 2	Homo sapiens	35-51
22131196-2	2012	Allyl isothiocyanate (AITC), phenylethyl isothiocyanate (PEITC), and sulforaphane (SFN), but not butyl isothiocyanate (BITC) resulted in dose-dependent induction of PON1 transactivation in Huh7 cells in vitro.	sulforaphane	69-81	paraoxonase 1	Homo sapiens	165-169
21956685-7	2012	SFN-treated MDA-MB-231 and MCF-7 cells also exhibited a marked decrease in protein level of peptidyl prolyl isomerase (Pin1), which is implicated in mitochondrial translocation of p66(shc) .	sulforaphane	0-3	SHC adaptor protein 1	Homo sapiens	184-187
21956685-3	2012	Immortalized mouse embryonic fibroblasts (MEF) derived from p66(shc) knockout mice were significantly more resistant to SFN-induced apoptosis, collapse of mitochondrial membrane potential, and reactive oxygen species (ROS) production compared with MEF obtained from the wild-type mice.	sulforaphane	120-123	src homology 2 domain-containing transforming protein C1	Mus musculus	60-63
21956685-3	2012	Immortalized mouse embryonic fibroblasts (MEF) derived from p66(shc) knockout mice were significantly more resistant to SFN-induced apoptosis, collapse of mitochondrial membrane potential, and reactive oxygen species (ROS) production compared with MEF obtained from the wild-type mice.	sulforaphane	120-123	src homology 2 domain-containing transforming protein C1	Mus musculus	64-67
21956685-6	2012	SFN treatment resulted in increased S36 phosphorylation and mitochondrial translocation of p66(shc) in MDA-MB-231 and MCF-7 cells, and SFN-induced apoptosis was significantly attenuated by RNA interference of p66(shc) in both cells.	sulforaphane	0-3	DNA polymerase delta 3, accessory subunit	Homo sapiens	91-94
21956685-6	2012	SFN treatment resulted in increased S36 phosphorylation and mitochondrial translocation of p66(shc) in MDA-MB-231 and MCF-7 cells, and SFN-induced apoptosis was significantly attenuated by RNA interference of p66(shc) in both cells.	sulforaphane	0-3	SHC adaptor protein 1	Homo sapiens	95-98
21956685-6	2012	SFN treatment resulted in increased S36 phosphorylation and mitochondrial translocation of p66(shc) in MDA-MB-231 and MCF-7 cells, and SFN-induced apoptosis was significantly attenuated by RNA interference of p66(shc) in both cells.	sulforaphane	0-3	DNA polymerase delta 3, accessory subunit	Homo sapiens	209-212
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	9-12	DNA polymerase delta 3, accessory subunit	Homo sapiens	44-47
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	9-12	SHC adaptor protein 1	Homo sapiens	48-51
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	9-12	protein kinase C beta	Homo sapiens	69-89
21956685-6	2012	SFN treatment resulted in increased S36 phosphorylation and mitochondrial translocation of p66(shc) in MDA-MB-231 and MCF-7 cells, and SFN-induced apoptosis was significantly attenuated by RNA interference of p66(shc) in both cells.	sulforaphane	0-3	SHC adaptor protein 1	Homo sapiens	213-216
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	9-12	protein kinase C beta	Homo sapiens	91-98
21956685-6	2012	SFN treatment resulted in increased S36 phosphorylation and mitochondrial translocation of p66(shc) in MDA-MB-231 and MCF-7 cells, and SFN-induced apoptosis was significantly attenuated by RNA interference of p66(shc) in both cells.	sulforaphane	135-138	DNA polymerase delta 3, accessory subunit	Homo sapiens	209-212
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	9-12	protein kinase C beta	Homo sapiens	135-142
21956685-6	2012	SFN treatment resulted in increased S36 phosphorylation and mitochondrial translocation of p66(shc) in MDA-MB-231 and MCF-7 cells, and SFN-induced apoptosis was significantly attenuated by RNA interference of p66(shc) in both cells.	sulforaphane	135-138	SHC adaptor protein 1	Homo sapiens	213-216
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	203-206	DNA polymerase delta 3, accessory subunit	Homo sapiens	44-47
21956685-7	2012	SFN-treated MDA-MB-231 and MCF-7 cells also exhibited a marked decrease in protein level of peptidyl prolyl isomerase (Pin1), which is implicated in mitochondrial translocation of p66(shc) .	sulforaphane	0-3	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	119-123
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	203-206	SHC adaptor protein 1	Homo sapiens	48-51
21956685-9	2012	Finally, SFN-induced S36 phosphorylation of p66(Shc) was mediated by protein kinase Cbeta (PKCbeta), and pharmacological inhibition of PKCbeta significantly inhibited apoptotic cell death resulting from SFN exposure.	sulforaphane	203-206	protein kinase C beta	Homo sapiens	135-142
21956685-10	2012	In conclusion, the present study provides new insight into the mechanism of SFN-induced apoptosis involving PKCbeta -mediated S36 phosphorylation of p66(shc).	sulforaphane	76-79	protein kinase C beta	Homo sapiens	108-115
21956685-10	2012	In conclusion, the present study provides new insight into the mechanism of SFN-induced apoptosis involving PKCbeta -mediated S36 phosphorylation of p66(shc).	sulforaphane	76-79	DNA polymerase delta 3, accessory subunit	Homo sapiens	149-152
21956685-10	2012	In conclusion, the present study provides new insight into the mechanism of SFN-induced apoptosis involving PKCbeta -mediated S36 phosphorylation of p66(shc).	sulforaphane	76-79	src homology 2 domain-containing transforming protein C1	Mus musculus	153-156
22302019-7	2012	alphaTOS in combination with sulforaphane, a compound that blocked LPS-induced COX-2 expression, cooperatively and more significantly inhibited PGE(2) production.	sulforaphane	29-41	cytochrome c oxidase II, mitochondrial	Mus musculus	79-84
22303412-3	2012	The ITC sulforaphane, which is derived from glucoraphanin, has garnered particular interest as an indirect antioxidant due to its extraordinary ability to induce expression of several enzymes via the KEAP1/Nrf2/ARE pathway.	sulforaphane	8-20	kelch like ECH associated protein 1	Homo sapiens	200-205
22303412-3	2012	The ITC sulforaphane, which is derived from glucoraphanin, has garnered particular interest as an indirect antioxidant due to its extraordinary ability to induce expression of several enzymes via the KEAP1/Nrf2/ARE pathway.	sulforaphane	8-20	NFE2 like bZIP transcription factor 2	Homo sapiens	206-210
22919281-1	2012	BACKGROUND: Sulforaphane (SFN), an activator of nuclear factor erythroid-2 related factor 2 (Nrf2), is a promising chemopreventive agent which is undergoing clinical trial for several diseases.	sulforaphane	12-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-91
22919281-1	2012	BACKGROUND: Sulforaphane (SFN), an activator of nuclear factor erythroid-2 related factor 2 (Nrf2), is a promising chemopreventive agent which is undergoing clinical trial for several diseases.	sulforaphane	12-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
22919281-1	2012	BACKGROUND: Sulforaphane (SFN), an activator of nuclear factor erythroid-2 related factor 2 (Nrf2), is a promising chemopreventive agent which is undergoing clinical trial for several diseases.	sulforaphane	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-91
22919281-1	2012	BACKGROUND: Sulforaphane (SFN), an activator of nuclear factor erythroid-2 related factor 2 (Nrf2), is a promising chemopreventive agent which is undergoing clinical trial for several diseases.	sulforaphane	26-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
22919281-11	2012	Interestingly, localized delivery of SFN significantly attenuated the growth of A549 tumors in nude mice, suggesting an Nrf2-independent antitumorigenic activity of SFN.	sulforaphane	37-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	120-124
21804859-4	2012	Incubations at higher SFN doses (12.5 and 25 muM) resulted in cleavage of procaspase-3 and elevated caspase-2, -3, -8, and -9 activity, suggesting that the induction of apoptosis and the sulforaphane-induced mitosis delay at the lower dose are independently regulated.	sulforaphane	187-199	caspase 2	Homo sapiens	100-125
23050040-3	2012	At the end of 3-month SFN treatment, the diabetic nephropathy, shown by renal inflammation, oxidative damage, fibrosis, and dysfunction, was significantly prevented along with an elevation of renal Nrf2 expression and transcription in diabetes/SFN group compared with diabetic group.	sulforaphane	22-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	198-202
23050040-6	2012	Blockade of Nrf2 expression completely abolished SFN prevention of the profibrotic effect induced by high glucose plus palmitate.	sulforaphane	49-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	12-16
23238480-8	2012	Since these enzymes are regulated by Nrf2 pathway, the localization of Nrf2 (Nuclear erythroid 2-related factor) after exposure to the mixtures of SFN and the drugs was evaluated by confocal microscopy.	sulforaphane	147-150	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
23238480-8	2012	Since these enzymes are regulated by Nrf2 pathway, the localization of Nrf2 (Nuclear erythroid 2-related factor) after exposure to the mixtures of SFN and the drugs was evaluated by confocal microscopy.	sulforaphane	147-150	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	collagen type XI alpha 2 chain	Homo sapiens	203-207
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	tumor protein p53	Homo sapiens	209-212
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	241-244
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	245-249
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	cyclin dependent kinase inhibitor 1A	Homo sapiens	250-254
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	cyclin dependent kinase 1	Homo sapiens	279-283
23251470-5	2012	The treatment of ALL leukemic cells with sulforaphane resulted in dose-dependent apoptosis and G2/M cell cycle arrest, which was associated with the activation of caspases (3, 8, and 9), inactivation of PARP, p53-independent upregulation of p21(CIP1/WAF1), and inhibition of the Cdc2/Cyclin B1 complex.	sulforaphane	41-53	cyclin B1	Homo sapiens	284-293
23251470-6	2012	Interestingly, sulforaphane also inhibited the AKT and mTOR survival pathways in most of the tested cell lines by lowering the levels of both total and phosphorylated proteins.	sulforaphane	15-27	AKT serine/threonine kinase 1	Homo sapiens	47-50
23251470-6	2012	Interestingly, sulforaphane also inhibited the AKT and mTOR survival pathways in most of the tested cell lines by lowering the levels of both total and phosphorylated proteins.	sulforaphane	15-27	mechanistic target of rapamycin kinase	Homo sapiens	55-59
23251470-7	2012	Finally, the administration of sulforaphane to the ALL xenograft models resulted in a reduction of tumor burden, particularly following oral administration, suggesting a potential role as an adjunctive agent to improve the therapeutic response in high-risk ALL patients with activated AKT signaling.	sulforaphane	31-43	AKT serine/threonine kinase 1	Homo sapiens	285-288
22911746-1	2012	Sulforaphane-induced activation of the transcription factor NF-E2 related factor 2 (Nrf2 or the gene Nfe2l2) and subsequent induction of the phase II antioxidant system has previously been shown to exert neuroprotective action in a transient model of focal cerebral ischemia.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	60-82
23166763-0	2012	Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1.	sulforaphane	0-12	prostaglandin E synthase	Homo sapiens	64-101
23166763-3	2012	We found that SFN indeed blocked PGE2 production in human A549 cancer cells not by inhibiting COX-2, but rather by suppressing the expression of microsomal prostaglandin E synthase (mPGES-1), the enzyme that directly synthesizes PGE2.	sulforaphane	14-17	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
23166763-3	2012	We found that SFN indeed blocked PGE2 production in human A549 cancer cells not by inhibiting COX-2, but rather by suppressing the expression of microsomal prostaglandin E synthase (mPGES-1), the enzyme that directly synthesizes PGE2.	sulforaphane	14-17	prostaglandin E synthase	Mus musculus	182-189
23166763-7	2012	Together, these results point to the HIF-1alpha, mPGES-1 and PGE2 axis as a potential mediator of the anti-cancer effects of SFN, and illustrate the potential of SFN for therapeutic control of cancer and inflammation.	sulforaphane	125-128	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-47
23071780-2	2012	Sulforaphane activating NF-E2-related nuclear factor erythroid-2 (Nrf-2) signaling may ameliorate UUO-induced renal damage.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-64
23071780-2	2012	Sulforaphane activating NF-E2-related nuclear factor erythroid-2 (Nrf-2) signaling may ameliorate UUO-induced renal damage.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-71
23071780-6	2012	Effects of sulforaphane, an Nrf-2 activator, on Nrf-2- and mitochondrial stress-related proteins and renal injury were examined.	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	28-33
23071780-6	2012	Effects of sulforaphane, an Nrf-2 activator, on Nrf-2- and mitochondrial stress-related proteins and renal injury were examined.	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-53
23071780-11	2012	Sulforaphane significantly increased nuclear Nrf-2 translocation and decreased mitochondrial Bax translocation and Cytochrome c release into cytosol resulting in decreased renal injury.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	45-50
23071780-11	2012	Sulforaphane significantly increased nuclear Nrf-2 translocation and decreased mitochondrial Bax translocation and Cytochrome c release into cytosol resulting in decreased renal injury.	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	93-96
23071780-12	2012	In conclusion, sulforaphane via activating Nrf-2 signaling preserved mitochondrial function and suppressed UUO-induced renal oxidative stress, inflammation, fibrosis, autophagy, apoptosis and pyroptosis.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-48
23029396-0	2012	Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal.	sulforaphane	83-95	sonic hedgehog signaling molecule	Homo sapiens	0-14
23029396-9	2012	Interference of Shh-Gli signaling significantly blocked SFN-induced inhibitory effects demonstrating the requirement of an active pathway for the growth of pancreatic CSCs.	sulforaphane	56-59	sonic hedgehog signaling molecule	Homo sapiens	16-19
23029396-9	2012	Interference of Shh-Gli signaling significantly blocked SFN-induced inhibitory effects demonstrating the requirement of an active pathway for the growth of pancreatic CSCs.	sulforaphane	56-59	GLI family zinc finger 1	Homo sapiens	20-23
23029396-11	2012	Furthermore, SFN induced apoptosis by inhibition of BCL-2 and activation of caspases.	sulforaphane	13-16	BCL2 apoptosis regulator	Homo sapiens	52-57
23029396-13	2012	We propose that pancreatic cancer preventative effects of SFN may result from inhibition of the Shh pathway.	sulforaphane	58-61	sonic hedgehog signaling molecule	Homo sapiens	96-99
22911746-1	2012	Sulforaphane-induced activation of the transcription factor NF-E2 related factor 2 (Nrf2 or the gene Nfe2l2) and subsequent induction of the phase II antioxidant system has previously been shown to exert neuroprotective action in a transient model of focal cerebral ischemia.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
22911746-1	2012	Sulforaphane-induced activation of the transcription factor NF-E2 related factor 2 (Nrf2 or the gene Nfe2l2) and subsequent induction of the phase II antioxidant system has previously been shown to exert neuroprotective action in a transient model of focal cerebral ischemia.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-107
22911746-6	2012	Sulforaphane increased transcription of Nrf2, Hmox1, GCLC and GSTA4 mRNA in the brain confirming activation of the Nrf2 system.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
22911746-6	2012	Sulforaphane increased transcription of Nrf2, Hmox1, GCLC and GSTA4 mRNA in the brain confirming activation of the Nrf2 system.	sulforaphane	0-12	heme oxygenase 1	Mus musculus	46-51
22911746-6	2012	Sulforaphane increased transcription of Nrf2, Hmox1, GCLC and GSTA4 mRNA in the brain confirming activation of the Nrf2 system.	sulforaphane	0-12	glutamate-cysteine ligase, catalytic subunit	Mus musculus	53-57
22911746-6	2012	Sulforaphane increased transcription of Nrf2, Hmox1, GCLC and GSTA4 mRNA in the brain confirming activation of the Nrf2 system.	sulforaphane	0-12	glutathione S-transferase, alpha 4	Mus musculus	62-67
22911746-6	2012	Sulforaphane increased transcription of Nrf2, Hmox1, GCLC and GSTA4 mRNA in the brain confirming activation of the Nrf2 system.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
22558388-8	2012	Here, we demonstrate that the addition of sulforaphane, a potent stimulator of antioxidant responses, enhanced HO-1 and Gpx1 expression in astrocytes through the activation of nuclear factor-E2-related factor 2 (Nrf2).	sulforaphane	42-54	heme oxygenase 1	Mus musculus	111-115
22558388-8	2012	Here, we demonstrate that the addition of sulforaphane, a potent stimulator of antioxidant responses, enhanced HO-1 and Gpx1 expression in astrocytes through the activation of nuclear factor-E2-related factor 2 (Nrf2).	sulforaphane	42-54	glutathione peroxidase 1	Mus musculus	120-124
22662208-5	2012	In the present study, we have observed that treatment of ERalpha-negative breast cancer cells with GTPs and SFN alone or in combination leads to the reactivation of ERalpha expression.	sulforaphane	108-111	estrogen receptor 1	Homo sapiens	57-64
22558388-8	2012	Here, we demonstrate that the addition of sulforaphane, a potent stimulator of antioxidant responses, enhanced HO-1 and Gpx1 expression in astrocytes through the activation of nuclear factor-E2-related factor 2 (Nrf2).	sulforaphane	42-54	nuclear factor, erythroid derived 2, like 2	Mus musculus	212-216
22662208-5	2012	In the present study, we have observed that treatment of ERalpha-negative breast cancer cells with GTPs and SFN alone or in combination leads to the reactivation of ERalpha expression.	sulforaphane	108-111	estrogen receptor 1	Homo sapiens	165-172
22005276-11	2011	Suppression of both p38 MAPK and JNK reversed H(2)S- or SFN-reduced viability of PC-3 cells.	sulforaphane	56-59	mitogen-activated protein kinase 14	Homo sapiens	20-23
22662208-6	2012	The combination of 20 microg/mL GTPs and 5 microM SFN was found to be the optimal dose of ERalpha-reactivation at 3 days in MDA-MB-231 cells.	sulforaphane	50-53	estrogen receptor 1	Homo sapiens	90-97
22558124-5	2012	Here, we show that while the activation of Nrf2 by prototypical chemical activators, including 5,6-dihydrocyclopenta-1,2-dithiole-3-thione (CPDT) and sulforaphane (SF), results solely from inhibition of its ubiquitination, such inhibition occurs predominantly in the nucleus.	sulforaphane	150-162	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
22558124-5	2012	Here, we show that while the activation of Nrf2 by prototypical chemical activators, including 5,6-dihydrocyclopenta-1,2-dithiole-3-thione (CPDT) and sulforaphane (SF), results solely from inhibition of its ubiquitination, such inhibition occurs predominantly in the nucleus.	sulforaphane	164-166	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
21986339-2	2011	This study tested the hypothesis that treatment of rats with sulforaphane (SFP), an activator of the Nrf2 pathway of antioxidant gene expression, increases the resistance of liver mitochondria to redox-regulated PTP opening and elevates mitochondrial levels of antioxidants.	sulforaphane	61-73	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-105
22005276-11	2011	Suppression of both p38 MAPK and JNK reversed H(2)S- or SFN-reduced viability of PC-3 cells.	sulforaphane	56-59	mitogen-activated protein kinase 8	Homo sapiens	33-36
21681606-0	2011	Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice.	sulforaphane	38-50	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
21681606-1	2011	PURPOSE: To determine the metabolism and tissue distribution of the dietary chemoprotective agent sulforaphane following oral administration to wild-type and Nrf2 knockout (Nrf2(-/-)) mice.	sulforaphane	98-110	nuclear factor, erythroid derived 2, like 2	Mus musculus	158-162
21681606-7	2011	Only Nrf2(-/-) females given 20 mumoles sulforaphane for 6 h exhibited a marked increase in tissue sulforaphane metabolite concentrations.	sulforaphane	40-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	5-9
21681606-7	2011	Only Nrf2(-/-) females given 20 mumoles sulforaphane for 6 h exhibited a marked increase in tissue sulforaphane metabolite concentrations.	sulforaphane	99-111	nuclear factor, erythroid derived 2, like 2	Mus musculus	5-9
21681606-9	2011	CONCLUSIONS: Sulforaphane is metabolized and reaches target tissues in wild-type and Nrf2(-/-) mice.	sulforaphane	13-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
21504366-7	2011	Consistently, treatment of mice with sulforaphane (an Nrf2 activator) suppressed T0901317-induced lipogenesis, as confirmed by the experiments using hepatocytes.	sulforaphane	37-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
22065904-1	2011	Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117
22065904-1	2011	Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117
22065904-6	2011	Erk1/2 was activated within 30 min of SFN addition, whereas Akt phosphorylation did not significantly change until the first 8 hr after SFN treatment but then became substantially low until 48 hr.	sulforaphane	38-41	mitogen-activated protein kinase 3	Homo sapiens	0-6
22065904-8	2011	Nrf2 protein levels in both nuclear and whole cell lysates were increased by SFN treatment, which was dependent on ROS production.	sulforaphane	77-80	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
22065904-9	2011	Knockdown of Nrf2 with siRNA attenuated SFN-induced heme oxygenase-1 (HO-1) up-regulation.	sulforaphane	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
22065904-9	2011	Knockdown of Nrf2 with siRNA attenuated SFN-induced heme oxygenase-1 (HO-1) up-regulation.	sulforaphane	40-43	heme oxygenase 1	Homo sapiens	52-68
22065904-10	2011	Induction of the Nrf2/HO-1 after SFN treatment was potently suppressed by pretreatment with NAC.	sulforaphane	33-36	NFE2 like bZIP transcription factor 2	Homo sapiens	17-21
21807989-8	2011	Sulforaphane treatment also increases cleavage of procaspase 3, 8, and 9 and enhances PARP cleavage and apoptosis.	sulforaphane	0-12	caspase 3	Homo sapiens	50-62
21807989-8	2011	Sulforaphane treatment also increases cleavage of procaspase 3, 8, and 9 and enhances PARP cleavage and apoptosis.	sulforaphane	0-12	collagen type XI alpha 2 chain	Homo sapiens	86-90
22023613-0	2011	Nrf2 and NF-kappaB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes.	sulforaphane	33-45	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
22023613-7	2011	Antioxidant effect of sulforaphane is derived from nuclear erythroid 2-related factor 2 (Nrf2) activation as demonstrated by increased expression of Nrf2 and downstream targets hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1) in neuro2a cells and sciatic nerve of diabetic animals.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-87
22023613-7	2011	Antioxidant effect of sulforaphane is derived from nuclear erythroid 2-related factor 2 (Nrf2) activation as demonstrated by increased expression of Nrf2 and downstream targets hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1) in neuro2a cells and sciatic nerve of diabetic animals.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
22023613-7	2011	Antioxidant effect of sulforaphane is derived from nuclear erythroid 2-related factor 2 (Nrf2) activation as demonstrated by increased expression of Nrf2 and downstream targets hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1) in neuro2a cells and sciatic nerve of diabetic animals.	sulforaphane	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
22023613-7	2011	Antioxidant effect of sulforaphane is derived from nuclear erythroid 2-related factor 2 (Nrf2) activation as demonstrated by increased expression of Nrf2 and downstream targets hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1) in neuro2a cells and sciatic nerve of diabetic animals.	sulforaphane	22-34	NAD(P)H dehydrogenase, quinone 1	Mus musculus	204-236
22023613-7	2011	Antioxidant effect of sulforaphane is derived from nuclear erythroid 2-related factor 2 (Nrf2) activation as demonstrated by increased expression of Nrf2 and downstream targets hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1) in neuro2a cells and sciatic nerve of diabetic animals.	sulforaphane	22-34	NAD(P)H dehydrogenase, quinone 1	Mus musculus	238-243
22023613-8	2011	Nuclear factor-kappa B (NF-kappaB) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-kappaB expression and IkappaB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) levels.	sulforaphane	104-116	nitric oxide synthase 2	Rattus norvegicus	230-261
22023613-8	2011	Nuclear factor-kappa B (NF-kappaB) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-kappaB expression and IkappaB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) levels.	sulforaphane	104-116	nitric oxide synthase 2	Rattus norvegicus	263-267
22023613-8	2011	Nuclear factor-kappa B (NF-kappaB) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-kappaB expression and IkappaB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) levels.	sulforaphane	104-116	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	273-289
22023613-8	2011	Nuclear factor-kappa B (NF-kappaB) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-kappaB expression and IkappaB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) levels.	sulforaphane	104-116	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	291-296
22023613-8	2011	Nuclear factor-kappa B (NF-kappaB) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-kappaB expression and IkappaB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) levels.	sulforaphane	104-116	tumor necrosis factor	Rattus norvegicus	313-340
22023613-8	2011	Nuclear factor-kappa B (NF-kappaB) inhibition seemed to be responsible for antiinflammatory activity of sulforaphane as there was reduction in NF-kappaB expression and IkappaB kinase (IKK) phosphorylation along with abrogation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression and tumor necrosis factor-alpha (TNF-alpha) and interleukine-6 (IL-6) levels.	sulforaphane	104-116	tumor necrosis factor	Rattus norvegicus	342-351
22025779-9	2011	Furthermore, SF or CA improved renal performance and minimized pathological alterations in the glomerulus of STZ-Nrf2(+/+) mice.	sulforaphane	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-117
22005302-7	2011	Treatment with sulforaphane, a small-molecule activator of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), was also able to denitrosylate HDAC2, restoring dexamethasone sensitivity in alveolar macrophages from patients with COPD.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	84-127
22005302-7	2011	Treatment with sulforaphane, a small-molecule activator of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), was also able to denitrosylate HDAC2, restoring dexamethasone sensitivity in alveolar macrophages from patients with COPD.	sulforaphane	15-27	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
22005302-7	2011	Treatment with sulforaphane, a small-molecule activator of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), was also able to denitrosylate HDAC2, restoring dexamethasone sensitivity in alveolar macrophages from patients with COPD.	sulforaphane	15-27	histone deacetylase 2	Homo sapiens	167-172
21640852-0	2011	Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.	sulforaphane	0-12	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	83-135
21640852-8	2011	Our findings suggest that SFN is a potent inducer of apoptosis in hepatocellular carcinoma cells via PFKFB4-inhibition pathways.	sulforaphane	26-29	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	Homo sapiens	101-107
21382770-6	2011	RESULTS: The isothiocyanates 6-methylsulfinylhexyl isothiocyanate (6-HITC) and sulforaphane (SFN) activated Nrf2 and up-regulated downstream proteins associated with MeHg excretion, such as glutamate-cysteine ligase, glutathione S-transferase, and multidrug resistance-associated protein, in primary mouse hepatocytes.	sulforaphane	79-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
21745450-8	2011	Intraperitoneal administration of sulforaphane significantly reversed the suppression of Nrf2, oxidative damage in the promoter of Cacna1c, and suppression of Cacna1c on day 7 of inflammation.	sulforaphane	34-46	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
21745450-8	2011	Intraperitoneal administration of sulforaphane significantly reversed the suppression of Nrf2, oxidative damage in the promoter of Cacna1c, and suppression of Cacna1c on day 7 of inflammation.	sulforaphane	34-46	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	131-138
21745450-8	2011	Intraperitoneal administration of sulforaphane significantly reversed the suppression of Nrf2, oxidative damage in the promoter of Cacna1c, and suppression of Cacna1c on day 7 of inflammation.	sulforaphane	34-46	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	159-166
21557998-0	2011	Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53.	sulforaphane	0-12	tumor protein p53	Homo sapiens	121-124
21799005-6	2011	The Nrf2 inducer sulforaphane (SFN) as well as ectopic Nrf2 expression or knock-down of the Nrf2 negative regulator keap1, which stabilizes Nrf2, inhibited RON expression and invasion of carcinoma cells.	sulforaphane	17-29	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
22417554-0	2011	Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway.	sulforaphane	36-48	AKT serine/threonine kinase 1	Rattus norvegicus	141-144
21764072-5	2011	Sulforaphane (SFN) was used to activate Nrf2 after SCI.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
21764072-5	2011	Sulforaphane (SFN) was used to activate Nrf2 after SCI.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
21617865-0	2011	Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice.	sulforaphane	0-12	pleckstrin homology domain containing B1	Homo sapiens	36-41
21617865-0	2011	Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice.	sulforaphane	0-12	pleckstrin homology domain containing B1	Homo sapiens	149-154
21617865-1	2011	The anticancer effects of sulforaphane (SFN), which is found in cruciferous vegetables, were studied on KPL-1 human breast cancer cells in vitro and in vivo.	sulforaphane	26-38	pleckstrin homology domain containing B1	Homo sapiens	104-109
21617865-1	2011	The anticancer effects of sulforaphane (SFN), which is found in cruciferous vegetables, were studied on KPL-1 human breast cancer cells in vitro and in vivo.	sulforaphane	40-43	pleckstrin homology domain containing B1	Homo sapiens	104-109
21617865-3	2011	The MTT assay showed that SFN directly inhibited KPL-1 cell growth in vitro (IC50 at 48 h, 19.1 microM; IC50 at 72 h, 17.8 microM).	sulforaphane	26-29	pleckstrin homology domain containing B1	Homo sapiens	49-54
21617865-11	2011	Treatment with 50 mg/kg SFN significantly inhibited KPL-1 cell growth in vivo by suppressing cell proliferation and inducing apoptosis, and it tended to reduce axillary lymph node metastasis of KPL-1 human breast cancer cell xenografts in female athymic mice.	sulforaphane	24-27	pleckstrin homology domain containing B1	Homo sapiens	52-57
21617865-11	2011	Treatment with 50 mg/kg SFN significantly inhibited KPL-1 cell growth in vivo by suppressing cell proliferation and inducing apoptosis, and it tended to reduce axillary lymph node metastasis of KPL-1 human breast cancer cell xenografts in female athymic mice.	sulforaphane	24-27	pleckstrin homology domain containing B1	Homo sapiens	194-199
21723306-7	2011	Using NCTC2544 human keratinocytes, we found that both sulforaphane and methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) stimulated nuclear localization of Nrf2 and induced expression of the GSH synthesis gene, GCLM.	sulforaphane	55-67	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
21723306-7	2011	Using NCTC2544 human keratinocytes, we found that both sulforaphane and methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) stimulated nuclear localization of Nrf2 and induced expression of the GSH synthesis gene, GCLM.	sulforaphane	55-67	glutamate-cysteine ligase modifier subunit	Homo sapiens	221-225
21684301-3	2011	In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells.	sulforaphane	36-48	NFE2 like bZIP transcription factor 2	Homo sapiens	134-156
21684301-3	2011	In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells.	sulforaphane	36-48	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
21684301-3	2011	In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells.	sulforaphane	50-53	NFE2 like bZIP transcription factor 2	Homo sapiens	134-156
21684301-3	2011	In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells.	sulforaphane	50-53	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
21557998-1	2011	Mechanisms and pathways responsible for cytotoxicity of sulforaphane (SF) in colon cancer cells with deleted p53 were investigated during 48 h of exposure.	sulforaphane	56-68	tumor protein p53	Homo sapiens	109-112
21557998-1	2011	Mechanisms and pathways responsible for cytotoxicity of sulforaphane (SF) in colon cancer cells with deleted p53 were investigated during 48 h of exposure.	sulforaphane	70-72	tumor protein p53	Homo sapiens	109-112
21720717-7	2011	Sulforaphane treatment also resulted in apoptosis as evidenced by an increase in annexin V+/propidium iodide- (V+/PI-) cells, the cleavage of 116-kDa poly (ADP-ribose) polymerase (PARP) and ICAD and oligonucleosomal DNA fragmentation.	sulforaphane	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	180-184
21720717-7	2011	Sulforaphane treatment also resulted in apoptosis as evidenced by an increase in annexin V+/propidium iodide- (V+/PI-) cells, the cleavage of 116-kDa poly (ADP-ribose) polymerase (PARP) and ICAD and oligonucleosomal DNA fragmentation.	sulforaphane	0-12	DNA fragmentation factor subunit alpha	Homo sapiens	190-194
24278567-8	2011	Pretreatment of antioxidants, N-acetylcysteine (NAC) and sulforaphane restored decreased viability of N990-treated A-10 cells, and N-acetylcysteine, but not sulforaphane, attenuated N990-induced ROS generation in A-10 cells.	sulforaphane	57-69	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	115-119
24278567-8	2011	Pretreatment of antioxidants, N-acetylcysteine (NAC) and sulforaphane restored decreased viability of N990-treated A-10 cells, and N-acetylcysteine, but not sulforaphane, attenuated N990-induced ROS generation in A-10 cells.	sulforaphane	57-69	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	213-217
21382770-6	2011	RESULTS: The isothiocyanates 6-methylsulfinylhexyl isothiocyanate (6-HITC) and sulforaphane (SFN) activated Nrf2 and up-regulated downstream proteins associated with MeHg excretion, such as glutamate-cysteine ligase, glutathione S-transferase, and multidrug resistance-associated protein, in primary mouse hepatocytes.	sulforaphane	79-91	hematopoietic prostaglandin D synthase	Mus musculus	217-287
21382770-6	2011	RESULTS: The isothiocyanates 6-methylsulfinylhexyl isothiocyanate (6-HITC) and sulforaphane (SFN) activated Nrf2 and up-regulated downstream proteins associated with MeHg excretion, such as glutamate-cysteine ligase, glutathione S-transferase, and multidrug resistance-associated protein, in primary mouse hepatocytes.	sulforaphane	93-96	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
21382770-6	2011	RESULTS: The isothiocyanates 6-methylsulfinylhexyl isothiocyanate (6-HITC) and sulforaphane (SFN) activated Nrf2 and up-regulated downstream proteins associated with MeHg excretion, such as glutamate-cysteine ligase, glutathione S-transferase, and multidrug resistance-associated protein, in primary mouse hepatocytes.	sulforaphane	93-96	hematopoietic prostaglandin D synthase	Mus musculus	217-287
21549835-7	2011	Conversely, supplementation with the potent Nrf2 activators sulforaphane (SFN) and epigallocatechin gallate (EGCG) significantly decreased viral entry and replication.	sulforaphane	60-72	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
21615272-6	2011	DIM was less potent than sulforaphane (used as positive control) in inducing Nrf2-dependent gene expression.	sulforaphane	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
21487929-7	2011	Further studies in HPHs demonstrated that selective inhibition of PXR by sulforaphane preferentially repressed IFO- over CPA-mediated induction of CYP2B6.	sulforaphane	73-85	nuclear receptor subfamily 1 group I member 2	Homo sapiens	66-69
21487929-7	2011	Further studies in HPHs demonstrated that selective inhibition of PXR by sulforaphane preferentially repressed IFO- over CPA-mediated induction of CYP2B6.	sulforaphane	73-85	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	147-153
21549835-7	2011	Conversely, supplementation with the potent Nrf2 activators sulforaphane (SFN) and epigallocatechin gallate (EGCG) significantly decreased viral entry and replication.	sulforaphane	74-77	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
21549835-9	2011	Interestingly, the induction of Nrf2 via nutritional supplements SFN and EGCG increased antiviral mediators/responses: RIG-I, IFN-beta, and MxA at baseline in the absence of infection.	sulforaphane	65-68	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
21656528-2	2011	The aim of this study was to examine the potential activation and synergism of Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3"-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).	sulforaphane	328-340	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
21793854-0	2011	Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.	sulforaphane	55-67	kelch like ECH associated protein 1	Homo sapiens	18-23
21793854-0	2011	Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications.	sulforaphane	55-67	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
21793854-4	2011	Sulforaphane is an electrophile that can react with protein thiols to form thionoacyl adducts and is believed to affect the Cys residues in Keap1 protein.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	140-145
21793854-5	2011	In addition, sulforaphane might affect the activity of a variety of intracellular kinases to phosphorylate Nrf2 proteins, which dictates the nucleocytoplasmic trafficking of Nrf2 or modulates the Nrf2 protein stability.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
21793854-5	2011	In addition, sulforaphane might affect the activity of a variety of intracellular kinases to phosphorylate Nrf2 proteins, which dictates the nucleocytoplasmic trafficking of Nrf2 or modulates the Nrf2 protein stability.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
21793854-5	2011	In addition, sulforaphane might affect the activity of a variety of intracellular kinases to phosphorylate Nrf2 proteins, which dictates the nucleocytoplasmic trafficking of Nrf2 or modulates the Nrf2 protein stability.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
21656528-2	2011	The aim of this study was to examine the potential activation and synergism of Nrf2-ARE-mediated transcriptional activity between four common phytochemicals present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3"-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).	sulforaphane	342-345	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
21602309-0	2011	Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.	sulforaphane	82-94	macrophage migration inhibitory factor	Homo sapiens	40-78
21602309-2	2011	Isothiocyanates, such as sulforaphane from broccoli, are very potent inactivators of MIF tautomerase activity.	sulforaphane	25-37	macrophage migration inhibitory factor	Homo sapiens	85-88
21602309-6	2011	RESULTS: A structure-potency study of MIF tautomerase inactivation by isothiocyanates showed that sulforaphane, benzyl, n-hexyl, and phenethyl isothiocyanates were especially potent.	sulforaphane	98-110	macrophage migration inhibitory factor	Homo sapiens	38-41
21649489-6	2011	SFN-induced apoptosis was associated with the activation of caspases 3 and 9, Bax, and p53 and the downregulation of Bcl-2, caspase-8, Bid, and NF-kB.	sulforaphane	0-3	caspase 3	Mus musculus	60-76
21649489-6	2011	SFN-induced apoptosis was associated with the activation of caspases 3 and 9, Bax, and p53 and the downregulation of Bcl-2, caspase-8, Bid, and NF-kB.	sulforaphane	0-3	BCL2-associated X protein	Mus musculus	78-81
21649489-6	2011	SFN-induced apoptosis was associated with the activation of caspases 3 and 9, Bax, and p53 and the downregulation of Bcl-2, caspase-8, Bid, and NF-kB.	sulforaphane	0-3	transformation related protein 53, pseudogene	Mus musculus	87-90
21649489-6	2011	SFN-induced apoptosis was associated with the activation of caspases 3 and 9, Bax, and p53 and the downregulation of Bcl-2, caspase-8, Bid, and NF-kB.	sulforaphane	0-3	B cell leukemia/lymphoma 2	Mus musculus	117-122
21649489-6	2011	SFN-induced apoptosis was associated with the activation of caspases 3 and 9, Bax, and p53 and the downregulation of Bcl-2, caspase-8, Bid, and NF-kB.	sulforaphane	0-3	caspase 8	Mus musculus	124-133
21649489-6	2011	SFN-induced apoptosis was associated with the activation of caspases 3 and 9, Bax, and p53 and the downregulation of Bcl-2, caspase-8, Bid, and NF-kB.	sulforaphane	0-3	BH3 interacting domain death agonist	Mus musculus	135-138
21649489-7	2011	Caspase-3 is a most likely candidate to mediate SFN-induced apoptosis.	sulforaphane	48-51	caspase 3	Mus musculus	0-9
20726001-3	2011	R-sulforaphane elevated hepatic glutathione S-transferase and quinone reductase whereas the S-enantiomer had no effect; moreover, the R-enantiomer was more effective in up-regulating GSTalpha, GSTmu and quinone reductase protein levels.	sulforaphane	0-14	hematopoietic prostaglandin D synthase	Rattus norvegicus	32-57
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	60-72	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	60-72	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	60-72	heme oxygenase 1	Mus musculus	186-202
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	60-72	NAD(P)H dehydrogenase, quinone 1	Mus musculus	246-250
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	74-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	74-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	74-77	heme oxygenase 1	Mus musculus	186-202
21254817-5	2011	Intraperitoneal administration of the potent Nrf2 activator sulforaphane (SFN) increased Nrf2 protein levels in the basal ganglia and led to upregulation of phase II antioxidant enzymes heme oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase (NQO1).	sulforaphane	74-77	NAD(P)H dehydrogenase, quinone 1	Mus musculus	246-250
21374800-5	2011	We observed that 15 muM SFN selectively induced cell cycle arrest and apoptosis in BPH1, LnCap and PC3 cells but not PrEC cells.	sulforaphane	24-27	keratin 6A	Homo sapiens	99-102
21374800-6	2011	SFN treatment also selectively decreased HDAC activity, and Class I and II HDAC proteins, increased acetylated histone H3 at the promoter for P21, induced p21 expression and increased tubulin acetylation in prostate cancer cells.	sulforaphane	0-3	H3 histone pseudogene 16	Homo sapiens	142-145
21374800-6	2011	SFN treatment also selectively decreased HDAC activity, and Class I and II HDAC proteins, increased acetylated histone H3 at the promoter for P21, induced p21 expression and increased tubulin acetylation in prostate cancer cells.	sulforaphane	0-3	H3 histone pseudogene 16	Homo sapiens	155-158
21374800-7	2011	HDAC6 over-expression was able to reverse SFN-induced cyotoxicity.	sulforaphane	42-45	histone deacetylase 6	Homo sapiens	0-5
21374800-9	2011	The differences in sensitivity to SFN in PrEC and PC3 are likely not due to differences in SFN metabolism or differences in phase 2 enzyme induction.	sulforaphane	34-37	keratin 6A	Homo sapiens	50-53
20726001-6	2011	Finally, R-sulforaphane was the more effective of the two isomers in up-regulating CYP1A1/1B1 apoprotein levels in both liver and lung, and CYP1A2 in the liver.	sulforaphane	9-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	83-93
20726001-6	2011	Finally, R-sulforaphane was the more effective of the two isomers in up-regulating CYP1A1/1B1 apoprotein levels in both liver and lung, and CYP1A2 in the liver.	sulforaphane	9-23	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	140-146
21401388-0	2011	Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.	sulforaphane	0-12	chemokine (C-X-C motif) ligand 15	Mus musculus	43-47
20956097-5	2011	Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1beta by RT-PCR on HeLa cells.	sulforaphane	34-46	BCL2 apoptosis regulator	Homo sapiens	68-73
20956097-5	2011	Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1beta by RT-PCR on HeLa cells.	sulforaphane	34-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	75-80
20956097-5	2011	Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1beta by RT-PCR on HeLa cells.	sulforaphane	34-46	interleukin 1 beta	Homo sapiens	85-93
20956097-8	2011	Also, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2 and IL-1beta upon treatment with sulforaphane.	sulforaphane	163-175	BCL2 apoptosis regulator	Homo sapiens	117-122
20956097-8	2011	Also, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2 and IL-1beta upon treatment with sulforaphane.	sulforaphane	163-175	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	124-129
20956097-8	2011	Also, the expression analysis of genes involved in apoptosis and inflammation revealed significant downregulation of Bcl-2, COX-2 and IL-1beta upon treatment with sulforaphane.	sulforaphane	163-175	interleukin 1 beta	Homo sapiens	134-142
21401388-0	2011	Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.	sulforaphane	0-12	chemokine (C-C motif) ligand 2	Mus musculus	52-57
21401388-6	2011	We hypothesized that activating NRF2-dependent cytoprotective gene expression with sulforaphane (SFN) affords protection against CS-induced lung damage by inhibiting chemokine production.	sulforaphane	83-95	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
21401388-6	2011	We hypothesized that activating NRF2-dependent cytoprotective gene expression with sulforaphane (SFN) affords protection against CS-induced lung damage by inhibiting chemokine production.	sulforaphane	97-100	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
21401388-9	2011	Production of both chemokines was significantly reduced with SFN given prior to CSE; SFN inhibited IL-8 and MCP-1 gene expression at the transcription level.	sulforaphane	61-64	C-C motif chemokine ligand 2	Homo sapiens	108-113
21401388-9	2011	Production of both chemokines was significantly reduced with SFN given prior to CSE; SFN inhibited IL-8 and MCP-1 gene expression at the transcription level.	sulforaphane	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
21401388-9	2011	Production of both chemokines was significantly reduced with SFN given prior to CSE; SFN inhibited IL-8 and MCP-1 gene expression at the transcription level.	sulforaphane	85-88	C-C motif chemokine ligand 2	Homo sapiens	108-113
21401388-10	2011	Our results indicate that activating NRF2 pathways with SFN inhibits CSE-induced chemokine production in human epithelial cells.	sulforaphane	56-59	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
21557329-2	2011	Previously, we have shown that sulforaphane (SFN) inhibited chemically induced skin carcinogenesis via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and others have shown that broccoli sprout extracts containing high SFN protected against UV-induced skin carcinogenesis in SKH-1 hairless mice.	sulforaphane	31-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152
21557329-2	2011	Previously, we have shown that sulforaphane (SFN) inhibited chemically induced skin carcinogenesis via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and others have shown that broccoli sprout extracts containing high SFN protected against UV-induced skin carcinogenesis in SKH-1 hairless mice.	sulforaphane	45-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152
21557329-8	2011	SFN treatment of Nrf2 WT but not Nrf2 KO mice restored the number of sunburn cells back to their basal level by 8 d after UVB irradiation.	sulforaphane	0-3	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
21557329-10	2011	Taken together, our results show that functional Nrf2 confers a protective effect against UVB-induced inflammation, sunburn reaction, and SFN-mediated photoprotective effects in the skin.	sulforaphane	138-141	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
21624135-0	2011	Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.	sulforaphane	45-57	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	118-122
21631512-4	2011	Curcumin, helenalin, and cinnamaldehyde with alpha, beta-unsaturated carbonyl groups, or sulforaphane with an isothiocyanate group, inhibit TLR4 activation by interfering with cysteine residue-mediated receptor dimerization, while resveratrol, with no unsaturated carbonyl group, did not.	sulforaphane	89-101	toll like receptor 4	Homo sapiens	140-144
21624135-0	2011	Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.	sulforaphane	45-57	histone deacetylase 3	Homo sapiens	126-131
21624135-0	2011	Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.	sulforaphane	45-57	nuclear receptor corepressor 2	Homo sapiens	132-136
21624135-9	2011	Co-immunoprecipitation assays revealed SFN-induced dissociation of HDAC3/SMRT complexes coinciding with increased binding of HDAC3 to 14-3-3 and peptidyl-prolyl cis/trans isomerase 1 (Pin1).	sulforaphane	39-42	histone deacetylase 3	Homo sapiens	67-72
21624135-9	2011	Co-immunoprecipitation assays revealed SFN-induced dissociation of HDAC3/SMRT complexes coinciding with increased binding of HDAC3 to 14-3-3 and peptidyl-prolyl cis/trans isomerase 1 (Pin1).	sulforaphane	39-42	nuclear receptor corepressor 2	Homo sapiens	73-77
21624135-9	2011	Co-immunoprecipitation assays revealed SFN-induced dissociation of HDAC3/SMRT complexes coinciding with increased binding of HDAC3 to 14-3-3 and peptidyl-prolyl cis/trans isomerase 1 (Pin1).	sulforaphane	39-42	histone deacetylase 3	Homo sapiens	125-130
21624135-9	2011	Co-immunoprecipitation assays revealed SFN-induced dissociation of HDAC3/SMRT complexes coinciding with increased binding of HDAC3 to 14-3-3 and peptidyl-prolyl cis/trans isomerase 1 (Pin1).	sulforaphane	39-42	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	145-182
21624135-9	2011	Co-immunoprecipitation assays revealed SFN-induced dissociation of HDAC3/SMRT complexes coinciding with increased binding of HDAC3 to 14-3-3 and peptidyl-prolyl cis/trans isomerase 1 (Pin1).	sulforaphane	39-42	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	184-188
21624135-10	2011	Pin1 knockdown blocked the SFN-induced loss of HDAC3.	sulforaphane	27-30	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	0-4
21624135-10	2011	Pin1 knockdown blocked the SFN-induced loss of HDAC3.	sulforaphane	27-30	histone deacetylase 3	Homo sapiens	47-52
21238579-0	2011	Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells.	sulforaphane	88-100	crystallin zeta	Homo sapiens	46-68
21391649-0	2011	Modification of keap1 cysteine residues by sulforaphane.	sulforaphane	43-55	kelch like ECH associated protein 1	Homo sapiens	16-21
21391649-2	2011	Sulforaphane, occurring in cruciferous vegetables such as broccoli, is a potent natural ARE activator that functions by modifying Keap1 cysteine residues, but there are conflicting in vitro and in vivo data regarding which of these cysteine residues react.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	130-135
21391649-4	2011	We have reconciled these conflicting data using mass spectrometry with a revised sample preparation protocol and confirmed that C151 is indeed among the most readily modified cysteines of Keap1 by sulforaphane.	sulforaphane	197-209	kelch like ECH associated protein 1	Homo sapiens	188-193
21391649-5	2011	Previous mass spectrometry-based studies used iodoacetamide during sample preparation to derivatize free cysteine sulfhydryl groups causing the loss of sulforaphane from highly reactive and reversible cysteine residues on Keap1 including C151.	sulforaphane	152-164	kelch like ECH associated protein 1	Homo sapiens	222-227
21391649-6	2011	By omitting iodoacetamide from the protocol and reducing sample preparation time, our mass spectrometry-based studies now confirm previous cell-based studies which showed that sulforaphane reacts with at least four cysteine residues of Keap1 including C151.	sulforaphane	176-188	kelch like ECH associated protein 1	Homo sapiens	236-241
21731800-5	2011	Since SERMs have antioxidant activity, ER-independent mechanisms were studied using the classical phenolic antioxidants, BHT and Trolox, and the Nrf2-dependent cytoprotective electrophile, sulforaphane.	sulforaphane	189-201	NFE2 like bZIP transcription factor 2	Rattus norvegicus	145-149
21238579-1	2011	Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5muM, 24h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 +- 0.6 (mean +- SEM)-fold, but intact-cell NQO1 activity by only 2.8 +- 0.1-fold compared to control cells.	sulforaphane	101-113	crystallin zeta	Homo sapiens	170-192
21238579-1	2011	Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5muM, 24h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 +- 0.6 (mean +- SEM)-fold, but intact-cell NQO1 activity by only 2.8 +- 0.1-fold compared to control cells.	sulforaphane	101-113	NAD(P)H quinone dehydrogenase 1	Bos taurus	194-198
21238579-1	2011	Treatment of bovine pulmonary arterial endothelial cells in culture with the phase II enzyme inducer sulforaphane (5muM, 24h; sulf-treated) increased cell-lysate NAD(P)H:quinone oxidoreductase (NQO1) activity by 5.7 +- 0.6 (mean +- SEM)-fold, but intact-cell NQO1 activity by only 2.8 +- 0.1-fold compared to control cells.	sulforaphane	101-113	NAD(P)H quinone dehydrogenase 1	Bos taurus	259-263
21238579-2	2011	To evaluate the hypothesis that the threshold for sulforaphane-induced intact-cell NQO1 activity reflects a limitation in the capacity to supply NADPH at a sufficient rate to drive all the induced NQO1 to its maximum activity, total KOH-extractable pyridine nucleotides were measured in cells treated with duroquinone to stimulate maximal NQO1 activity.	sulforaphane	50-62	NAD(P)H quinone dehydrogenase 1	Homo sapiens	83-87
21238579-2	2011	To evaluate the hypothesis that the threshold for sulforaphane-induced intact-cell NQO1 activity reflects a limitation in the capacity to supply NADPH at a sufficient rate to drive all the induced NQO1 to its maximum activity, total KOH-extractable pyridine nucleotides were measured in cells treated with duroquinone to stimulate maximal NQO1 activity.	sulforaphane	50-62	NAD(P)H quinone dehydrogenase 1	Homo sapiens	197-201
21238579-2	2011	To evaluate the hypothesis that the threshold for sulforaphane-induced intact-cell NQO1 activity reflects a limitation in the capacity to supply NADPH at a sufficient rate to drive all the induced NQO1 to its maximum activity, total KOH-extractable pyridine nucleotides were measured in cells treated with duroquinone to stimulate maximal NQO1 activity.	sulforaphane	50-62	NAD(P)H quinone dehydrogenase 1	Homo sapiens	197-201
21490276-4	2011	Here, we test whether activation of Nrf2 by the phytochemical sulforaphane restores phagocytosis of clinical isolates of nontypeable Haemophilus influenza (NTHI) and Pseudomonas aeruginosa (PA) by alveolar macrophages from patients with COPD.	sulforaphane	62-74	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
21490276-8	2011	Disruption of Nrf2 or MARCO abrogated sulforaphane-mediated bacterial phagocytosis by COPD alveolar macrophages.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
21490276-8	2011	Disruption of Nrf2 or MARCO abrogated sulforaphane-mediated bacterial phagocytosis by COPD alveolar macrophages.	sulforaphane	38-50	macrophage receptor with collagenous structure	Homo sapiens	22-27
21490276-9	2011	Our findings demonstrate the importance of Nrf2 and its downstream target MARCO in improving antibacterial defenses and provide a rationale for targeting this pathway, via pharmacological agents such as sulforaphane, to prevent exacerbations of COPD caused by bacterial infection.	sulforaphane	203-215	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
21490276-9	2011	Our findings demonstrate the importance of Nrf2 and its downstream target MARCO in improving antibacterial defenses and provide a rationale for targeting this pathway, via pharmacological agents such as sulforaphane, to prevent exacerbations of COPD caused by bacterial infection.	sulforaphane	203-215	macrophage receptor with collagenous structure	Homo sapiens	74-79
23199123-3	2011	This review focuses on sulforaphane, an isothiocyanate derived from green vegetables, which induces multiple anti-oxidant enzymes via activation of a transcription factor called Nrf2.	sulforaphane	23-35	NFE2 like bZIP transcription factor 2	Homo sapiens	178-182
21303654-7	2011	We showed that two Nrf2 activators, diethyl maleate and sulforaphane (SFN; a natural Nrf2 activator found in broccoli), restored the LPS-induced suppression of Fpn1 mRNA in human and mouse macrophages, respectively.	sulforaphane	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
21303654-7	2011	We showed that two Nrf2 activators, diethyl maleate and sulforaphane (SFN; a natural Nrf2 activator found in broccoli), restored the LPS-induced suppression of Fpn1 mRNA in human and mouse macrophages, respectively.	sulforaphane	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
21303654-7	2011	We showed that two Nrf2 activators, diethyl maleate and sulforaphane (SFN; a natural Nrf2 activator found in broccoli), restored the LPS-induced suppression of Fpn1 mRNA in human and mouse macrophages, respectively.	sulforaphane	56-68	solute carrier family 40 member 1	Homo sapiens	160-164
21303654-7	2011	We showed that two Nrf2 activators, diethyl maleate and sulforaphane (SFN; a natural Nrf2 activator found in broccoli), restored the LPS-induced suppression of Fpn1 mRNA in human and mouse macrophages, respectively.	sulforaphane	70-73	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
21303654-7	2011	We showed that two Nrf2 activators, diethyl maleate and sulforaphane (SFN; a natural Nrf2 activator found in broccoli), restored the LPS-induced suppression of Fpn1 mRNA in human and mouse macrophages, respectively.	sulforaphane	70-73	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
21303654-7	2011	We showed that two Nrf2 activators, diethyl maleate and sulforaphane (SFN; a natural Nrf2 activator found in broccoli), restored the LPS-induced suppression of Fpn1 mRNA in human and mouse macrophages, respectively.	sulforaphane	70-73	solute carrier family 40 member 1	Homo sapiens	160-164
21259333-4	2011	In experiment 2, we assessed the effect of sulforaphane (SUL; a specific Nrf2 activator) on regulation of the Nrf2-ARE pathway in the SAH model and evaluated the impact of SUL on EBI after SAH.	sulforaphane	43-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	73-77
21259333-4	2011	In experiment 2, we assessed the effect of sulforaphane (SUL; a specific Nrf2 activator) on regulation of the Nrf2-ARE pathway in the SAH model and evaluated the impact of SUL on EBI after SAH.	sulforaphane	57-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	73-77
21259333-4	2011	In experiment 2, we assessed the effect of sulforaphane (SUL; a specific Nrf2 activator) on regulation of the Nrf2-ARE pathway in the SAH model and evaluated the impact of SUL on EBI after SAH.	sulforaphane	57-60	NFE2 like bZIP transcription factor 2	Rattus norvegicus	110-114
21259333-7	2011	After intraperitoneal SUL administration, the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-alpha1 (GST-alpha1) was detected in the cortex at 48 hr following blood injection.	sulforaphane	22-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	69-73
21259333-7	2011	After intraperitoneal SUL administration, the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-alpha1 (GST-alpha1) was detected in the cortex at 48 hr following blood injection.	sulforaphane	22-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	102-106
21259333-7	2011	After intraperitoneal SUL administration, the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-alpha1 (GST-alpha1) was detected in the cortex at 48 hr following blood injection.	sulforaphane	22-25	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	114-146
21259333-7	2011	After intraperitoneal SUL administration, the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-alpha1 (GST-alpha1) was detected in the cortex at 48 hr following blood injection.	sulforaphane	22-25	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	148-152
21259333-7	2011	After intraperitoneal SUL administration, the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-alpha1 (GST-alpha1) was detected in the cortex at 48 hr following blood injection.	sulforaphane	22-25	glutathione S-transferase alpha 1	Rattus norvegicus	159-191
21259333-7	2011	After intraperitoneal SUL administration, the elevated expression of Nrf2-ARE-related factors such as Nrf2, HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutathione S-transferase-alpha1 (GST-alpha1) was detected in the cortex at 48 hr following blood injection.	sulforaphane	22-25	glutathione S-transferase alpha 1	Rattus norvegicus	193-203
20857431-0	2011	Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity.	sulforaphane	135-147	glutathione S-transferase alpha 1	Homo sapiens	46-50
20857431-0	2011	Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity.	sulforaphane	135-147	glutathione S-transferase alpha 1	Homo sapiens	72-77
21219867-8	2011	It has been shown recently that sulforaphane is a potent and direct inactivator of macrophage migration inhibitory factor (MIF), an inflammatory cytokine.	sulforaphane	32-44	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	83-121
21468572-0	2011	Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	51-56
21468572-5	2011	Sulforaphane (SFN), a phenethyl isothiocyanate, elicits HIF-1alpha inactivation under hypoxia.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
21468572-5	2011	Sulforaphane (SFN), a phenethyl isothiocyanate, elicits HIF-1alpha inactivation under hypoxia.	sulforaphane	14-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66
21468572-6	2011	This study investigated whether hypoxic inhibition of TRAIL-mediated tumor cell death is increased by SFN-mediated HIF-1alpha instability.	sulforaphane	102-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
21468572-10	2011	SFN treatment enhanced TRAIL-induced activation of proteins, including caspase-3 and p53.	sulforaphane	0-3	TNF superfamily member 10	Homo sapiens	23-28
21468572-10	2011	SFN treatment enhanced TRAIL-induced activation of proteins, including caspase-3 and p53.	sulforaphane	0-3	caspase 3	Homo sapiens	71-80
21468572-10	2011	SFN treatment enhanced TRAIL-induced activation of proteins, including caspase-3 and p53.	sulforaphane	0-3	tumor protein p53	Homo sapiens	85-88
21468572-12	2011	This study demonstrated that SFN recovered hypoxia-mediated resistance to TRAIL via instability of HIF-1alpha, and also suggests that combination therapy with SFN and TRAIL may provide a novel strategy for treating hypoxic solid tumors.	sulforaphane	29-32	TNF superfamily member 10	Homo sapiens	74-79
21468572-12	2011	This study demonstrated that SFN recovered hypoxia-mediated resistance to TRAIL via instability of HIF-1alpha, and also suggests that combination therapy with SFN and TRAIL may provide a novel strategy for treating hypoxic solid tumors.	sulforaphane	29-32	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
21109004-1	2011	The isothiocyanate sulforaphane (SFN) has been shown to induce phase 2 and antioxidant enzymes in cultured cells and in vivo via a Nrf2 dependent signal transduction pathway.	sulforaphane	33-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
21219867-8	2011	It has been shown recently that sulforaphane is a potent and direct inactivator of macrophage migration inhibitory factor (MIF), an inflammatory cytokine.	sulforaphane	32-44	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	123-126
21219867-9	2011	Moreover, the addition of recombinant MIF to RAW 264.7 cells attenuated phagocytosis, but sulforaphane-inactivated MIF did not affect phagocytosis.	sulforaphane	90-102	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	115-118
21219867-10	2011	The inactivation of MIF may therefore be involved in the phagocytosis-enhancing activity of sulforaphane.	sulforaphane	92-104	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	20-23
21177068-5	2011	We demonstrated the inhibitory effects of orally administered sulforaphane on B[a]P-induced aryl hydrocarbon receptor (AHR) activation which subsequently resulted in decreased Phase-I enzyme activities in vivo.	sulforaphane	62-74	aryl-hydrocarbon receptor	Mus musculus	92-117
21177068-5	2011	We demonstrated the inhibitory effects of orally administered sulforaphane on B[a]P-induced aryl hydrocarbon receptor (AHR) activation which subsequently resulted in decreased Phase-I enzyme activities in vivo.	sulforaphane	62-74	aryl-hydrocarbon receptor	Mus musculus	119-122
21177068-6	2011	The study also highlights that treatment with sulforaphane enhanced the Nuclear factor erythroid 2-related factor 2 (Nrf2) transcription which reflects its nuclear accumulation and DNA binding in mice, together with the induction of phase II enzymes as evident from our results.	sulforaphane	46-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-115
21177068-6	2011	The study also highlights that treatment with sulforaphane enhanced the Nuclear factor erythroid 2-related factor 2 (Nrf2) transcription which reflects its nuclear accumulation and DNA binding in mice, together with the induction of phase II enzymes as evident from our results.	sulforaphane	46-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
20888844-8	2011	Sulforaphane stimulation for 4 h induced an Nrf2-dependent increase of Nqo1 and Hmox1 mRNA that remained elevated for 24 h, and the corresponding proteins remained elevated for over 48 h. In addition, peroxide-clearing activity and the levels of glutathione were elevated for more than 20 h after stimulation for 4 h with sulforaphane, resulting in an increased resistance to superoxide-induced cell damage.	sulforaphane	322-334	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
20888844-9	2011	Repeated sulforaphane stimulation resulted in an accumulation of mRNA and protein levels of Nqo1 and a persistent cell protection against oxidative damage.	sulforaphane	9-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	92-96
20888844-0	2011	Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
20888844-3	2011	Nrf2 can also be activated by xenobiotics like sulforaphane, a component highly enriched in cruciferous vegetables such as broccoli.	sulforaphane	47-59	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
20888844-10	2011	These findings indicate that brief stimulation of the Nrf2 pathway by sulforaphane results in long-lasting elevation of endogenous antioxidants in astrocytes.	sulforaphane	70-82	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
20888844-5	2011	Here we have examined whether the prolonged protection induced by sulforaphane is explained by a slow down regulation of the Nrf2 response.	sulforaphane	66-78	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
21196331-5	2011	SFN induced apoptosis by inhibiting the expression of Bcl-2 and XIAP, phosphorylation of FKHR, and activating caspase-3.	sulforaphane	0-3	BCL2 apoptosis regulator	Homo sapiens	54-59
20888844-6	2011	Furthermore, to simulate daily ingestion of sulforaphane, we examined the hypothesis that repeated transient sulforaphane stimulation results in an accumulation of Nrf2-mediated gene expression and an increased protection against oxidative damage.	sulforaphane	109-121	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
20888844-7	2011	The kinetics of sulforaphane-induced Nrf2 response was studied in astrocytes, a cell type known to be highly involved in the defense against oxidative stress in the brain.	sulforaphane	16-28	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
20888844-8	2011	Sulforaphane stimulation for 4 h induced an Nrf2-dependent increase of Nqo1 and Hmox1 mRNA that remained elevated for 24 h, and the corresponding proteins remained elevated for over 48 h. In addition, peroxide-clearing activity and the levels of glutathione were elevated for more than 20 h after stimulation for 4 h with sulforaphane, resulting in an increased resistance to superoxide-induced cell damage.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
20888844-8	2011	Sulforaphane stimulation for 4 h induced an Nrf2-dependent increase of Nqo1 and Hmox1 mRNA that remained elevated for 24 h, and the corresponding proteins remained elevated for over 48 h. In addition, peroxide-clearing activity and the levels of glutathione were elevated for more than 20 h after stimulation for 4 h with sulforaphane, resulting in an increased resistance to superoxide-induced cell damage.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-75
20888844-8	2011	Sulforaphane stimulation for 4 h induced an Nrf2-dependent increase of Nqo1 and Hmox1 mRNA that remained elevated for 24 h, and the corresponding proteins remained elevated for over 48 h. In addition, peroxide-clearing activity and the levels of glutathione were elevated for more than 20 h after stimulation for 4 h with sulforaphane, resulting in an increased resistance to superoxide-induced cell damage.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	80-85
20887713-4	2011	Real-time RT-PCR analysis revealed that the CYP2A6 mRNA level in human hepatocytes was significantly (P<0.01, 1.4-fold) induced by 10muM sulforaphane (SFN), a typical activator of Nrf2.	sulforaphane	140-152	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	44-50
20887713-4	2011	Real-time RT-PCR analysis revealed that the CYP2A6 mRNA level in human hepatocytes was significantly (P<0.01, 1.4-fold) induced by 10muM sulforaphane (SFN), a typical activator of Nrf2.	sulforaphane	154-157	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	44-50
20887713-4	2011	Real-time RT-PCR analysis revealed that the CYP2A6 mRNA level in human hepatocytes was significantly (P<0.01, 1.4-fold) induced by 10muM sulforaphane (SFN), a typical activator of Nrf2.	sulforaphane	154-157	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
21280976-0	2011	Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury.	sulforaphane	0-13	aquaporin 4	Mus musculus	23-34
21280976-2	2011	Sulphoraphane (SFN) increases AQP4 levels with reduction of brain oedema at 3 days post-traumatic brain injury.	sulforaphane	0-13	RNA exonuclease 2	Mus musculus	15-18
21280976-2	2011	Sulphoraphane (SFN) increases AQP4 levels with reduction of brain oedema at 3 days post-traumatic brain injury.	sulforaphane	0-13	aquaporin 4	Mus musculus	30-34
22303414-0	2011	Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells.	sulforaphane	40-52	cyclin D2	Homo sapiens	27-36
20888374-7	2011	MCF-7 cells treated with sulforaphane, an autophagy-inducing drug, also showed marked accumulation of LC3-II, and co-treatment with caspase-9 inhibitor brought about increased susceptibility to sulforaphane-induced cell death.	sulforaphane	25-37	caspase 9	Homo sapiens	132-141
20888374-7	2011	MCF-7 cells treated with sulforaphane, an autophagy-inducing drug, also showed marked accumulation of LC3-II, and co-treatment with caspase-9 inhibitor brought about increased susceptibility to sulforaphane-induced cell death.	sulforaphane	194-206	caspase 9	Homo sapiens	132-141
20888374-8	2011	Different from the cases with FR or sulforaphane, etoposide- or doxorubicin-induced cell death was suppressed with co-treatment of caspase-9 inhibitor, and the drugs failed to induce significant autophagy in MCF-7 cells.	sulforaphane	36-48	caspase 9	Homo sapiens	131-140
21196331-5	2011	SFN induced apoptosis by inhibiting the expression of Bcl-2 and XIAP, phosphorylation of FKHR, and activating caspase-3.	sulforaphane	0-3	X-linked inhibitor of apoptosis	Homo sapiens	64-68
21196331-5	2011	SFN induced apoptosis by inhibiting the expression of Bcl-2 and XIAP, phosphorylation of FKHR, and activating caspase-3.	sulforaphane	0-3	forkhead box O1	Homo sapiens	89-93
21196331-5	2011	SFN induced apoptosis by inhibiting the expression of Bcl-2 and XIAP, phosphorylation of FKHR, and activating caspase-3.	sulforaphane	0-3	caspase 3	Homo sapiens	110-119
21358121-0	2011	Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate.	sulforaphane	177-189	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
21358121-4	2011	Sulforaphane and 6-HITC induced the translocation of nuclear factor E2-related factor 2 (Nrf2) into the nucleus and increased the expression of gamma-glutamylcysteine synthetase (gamma-GCS), a rate-limiting enzyme in glutathione synthesis, and the intracellular glutathione content.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
21358121-4	2011	Sulforaphane and 6-HITC induced the translocation of nuclear factor E2-related factor 2 (Nrf2) into the nucleus and increased the expression of gamma-glutamylcysteine synthetase (gamma-GCS), a rate-limiting enzyme in glutathione synthesis, and the intracellular glutathione content.	sulforaphane	0-12	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	144-177
21358121-4	2011	Sulforaphane and 6-HITC induced the translocation of nuclear factor E2-related factor 2 (Nrf2) into the nucleus and increased the expression of gamma-glutamylcysteine synthetase (gamma-GCS), a rate-limiting enzyme in glutathione synthesis, and the intracellular glutathione content.	sulforaphane	0-12	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	179-188
21358121-6	2011	Moreover, exposure to L-buthionine-sulfoximine, an irreversible inhibitor of gamma-GCS, suppressed the protective effects of sulforaphane and 6-HITC.	sulforaphane	125-137	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	77-86
21358121-7	2011	In contrast, sulforaphane and 6-HITC increased heme oxygenase-1 (HO-1) expression in neurons.	sulforaphane	13-25	heme oxygenase 1	Rattus norvegicus	47-63
21358121-7	2011	In contrast, sulforaphane and 6-HITC increased heme oxygenase-1 (HO-1) expression in neurons.	sulforaphane	13-25	heme oxygenase 1	Rattus norvegicus	65-69
21358121-9	2011	These results suggest that sulforaphane and 6-HITC prevent oxidative stress-induced cytotoxicity in rat striatal cultures by raising the intracellular glutathione content via an increase in gamma-GCS expression induced by the activation of the Nrf2-antioxidant response element pathway.	sulforaphane	27-39	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	190-199
21358121-9	2011	These results suggest that sulforaphane and 6-HITC prevent oxidative stress-induced cytotoxicity in rat striatal cultures by raising the intracellular glutathione content via an increase in gamma-GCS expression induced by the activation of the Nrf2-antioxidant response element pathway.	sulforaphane	27-39	NFE2 like bZIP transcription factor 2	Rattus norvegicus	244-248
20736322-11	2010	In HepaRG cells, N-methylcytisine significantly induced CYP3A4 expression, and this induction was suppressed by the PXR antagonist sulforaphane.	sulforaphane	131-143	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-62
21271458-6	2011	In contrast, SFN enhanced the phosphorylation of stress-activated protein kinase (SAPK) and decreased cellular myelocytomatosis oncogene (c-Myc) expression in HCT116 cells but not NCM460 cells.	sulforaphane	13-16	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-136
21271458-6	2011	In contrast, SFN enhanced the phosphorylation of stress-activated protein kinase (SAPK) and decreased cellular myelocytomatosis oncogene (c-Myc) expression in HCT116 cells but not NCM460 cells.	sulforaphane	13-16	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	138-143
22046393-5	2011	Tissue-restricted induction was observed in the nose, gill, and/or liver for all seven genes in response to Nrf2-activating compounds, diethylmaleate (DEM) and sulforaphane.	sulforaphane	160-172	nfe2 like bZIP transcription factor 2a	Danio rerio	108-112
21159204-0	2010	Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells.	sulforaphane	49-61	phosphoglucomutase 3	Homo sapiens	19-39
21159204-7	2010	CONCLUSION: Taken together, these findings suggest that PGM3 plays a role in mediating SFN-induced cell death in LNCaP cells, and is a potential molecular therapeutic target for prostate cancer.	sulforaphane	87-90	phosphoglucomutase 3	Homo sapiens	56-60
21875325-0	2011	Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function.	sulforaphane	0-12	heat shock protein 90 alpha family class A member 1	Homo sapiens	137-142
21875325-3	2011	MTS assay demonstrated that sulforaphane sensitized pancreatic cancer cells to 17-AAG in vitro.	sulforaphane	28-40	N-methylpurine DNA glycosylase	Homo sapiens	82-85
21875325-4	2011	Caspase-3 was activated to 6.4-fold in response to simultaneous treatment with sulforaphane and 17-AAG, whereas 17-AAG alone induced caspase-3 activity to 2-fold compared to control.	sulforaphane	79-91	caspase 3	Homo sapiens	0-9
21875325-5	2011	ATP binding assay and coimmunoprecipitation revealed that sulforaphane disrupted Hsp90-p50(Cdc37) interaction, whereas 17-AAG inhibited ATP binding to Hsp90.	sulforaphane	58-70	heat shock protein 90 alpha family class A member 1	Homo sapiens	81-86
21875325-5	2011	ATP binding assay and coimmunoprecipitation revealed that sulforaphane disrupted Hsp90-p50(Cdc37) interaction, whereas 17-AAG inhibited ATP binding to Hsp90.	sulforaphane	58-70	nuclear factor kappa B subunit 1	Homo sapiens	87-90
21875325-5	2011	ATP binding assay and coimmunoprecipitation revealed that sulforaphane disrupted Hsp90-p50(Cdc37) interaction, whereas 17-AAG inhibited ATP binding to Hsp90.	sulforaphane	58-70	cell division cycle 37, HSP90 cochaperone	Homo sapiens	91-96
21875325-6	2011	Concomitant use of sulforaphane and 17-AAG synergistically downregulated Hsp90 client proteins in Mia Paca-2 cells.	sulforaphane	19-31	heat shock protein 90 alpha family class A member 1	Homo sapiens	73-78
21875325-8	2011	Our data suggest that sulforaphane potentiates the efficacy of 17-AAG against pancreatic cancer through enhanced abrogation of Hsp90 function.	sulforaphane	22-34	N-methylpurine DNA glycosylase	Homo sapiens	66-69
21875325-8	2011	Our data suggest that sulforaphane potentiates the efficacy of 17-AAG against pancreatic cancer through enhanced abrogation of Hsp90 function.	sulforaphane	22-34	heat shock protein 90 alpha family class A member 1	Homo sapiens	127-132
20736322-11	2010	In HepaRG cells, N-methylcytisine significantly induced CYP3A4 expression, and this induction was suppressed by the PXR antagonist sulforaphane.	sulforaphane	131-143	nuclear receptor subfamily 1 group I member 2	Homo sapiens	116-119
20816911-0	2010	Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross.	sulforaphane	0-12	Cytochrome P450-6a2	Drosophila melanogaster	41-47
20816911-0	2010	Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross.	sulforaphane	0-12	Cyp6g1	Drosophila melanogaster	52-58
20816911-6	2010	Sulforaphane decreased Cyp6g1 in the HB cross and increased it in the ST cross; Cyp6a2 expression was inhibited in the ST cross.	sulforaphane	0-12	Cyp6g1	Drosophila melanogaster	23-29
20816911-7	2010	Sulforaphane resulted mutagenic in the ST cross, which could be related to the inhibition of Cyp6a2.	sulforaphane	0-12	Cytochrome P450-6a2	Drosophila melanogaster	93-99
21061051-2	2010	One approach to pre-conditioning against oxidative stress is pharmacologic activation of the Nrf2/ARE pathway of antioxidant gene expression by agents such as sulforaphane (SFP).	sulforaphane	159-171	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
21061051-2	2010	One approach to pre-conditioning against oxidative stress is pharmacologic activation of the Nrf2/ARE pathway of antioxidant gene expression by agents such as sulforaphane (SFP).	sulforaphane	173-176	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
20732396-1	2010	This work was designed to further study the mechanism by which sulforaphane (SFN) exerts a renoprotective effect against cisplatin (CIS)-induced damage.	sulforaphane	63-75	14-3-3 protein sigma	Sus scrofa	77-80
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	50-52	keratin 16	Mus musculus	152-155
20926689-0	2010	Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia.	sulforaphane	49-61	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	36-48	keratin 14	Mus musculus	85-95
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	36-48	keratin 14	Mus musculus	97-100
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	36-48	keratin 16	Mus musculus	152-155
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	36-48	keratin 17	Mus musculus	160-163
20732396-0	2010	Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and gamma glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells.	sulforaphane	21-33	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	120-153
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	50-52	keratin 14	Mus musculus	85-95
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	50-52	keratin 14	Mus musculus	97-100
20926689-1	2010	Treatment with the natural chemical sulforaphane (SF) ameliorates skin blistering in keratin 14 (K14)-deficient mice, correlating with the induction of K16 and K17 in the basal layer of epidermis (Kerns et al., PNAS 104:14460, 2007).	sulforaphane	50-52	keratin 17	Mus musculus	160-163
20732396-1	2010	This work was designed to further study the mechanism by which sulforaphane (SFN) exerts a renoprotective effect against cisplatin (CIS)-induced damage.	sulforaphane	63-75	cytokine inducible SH2 containing protein	Sus scrofa	132-135
20953205-3	2010	Sulforaphane (SFN), a potent Nrf2 activator, was used to activate Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
20953205-3	2010	Sulforaphane (SFN), a potent Nrf2 activator, was used to activate Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
20953205-3	2010	Sulforaphane (SFN), a potent Nrf2 activator, was used to activate Nrf2.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
20953205-3	2010	Sulforaphane (SFN), a potent Nrf2 activator, was used to activate Nrf2.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
20953205-6	2010	RESULTS: Activation of Nrf2 by SFN( 5 mg/kg, ip) induced the nuclear translocation and activation of Nrf2, which resulted in an up-regulation of Nrf2-dependent antioxidant enzymes and a reduction of oxidative damage after TBI.	sulforaphane	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
20953205-6	2010	RESULTS: Activation of Nrf2 by SFN( 5 mg/kg, ip) induced the nuclear translocation and activation of Nrf2, which resulted in an up-regulation of Nrf2-dependent antioxidant enzymes and a reduction of oxidative damage after TBI.	sulforaphane	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
20953205-6	2010	RESULTS: Activation of Nrf2 by SFN( 5 mg/kg, ip) induced the nuclear translocation and activation of Nrf2, which resulted in an up-regulation of Nrf2-dependent antioxidant enzymes and a reduction of oxidative damage after TBI.	sulforaphane	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
20953205-10	2010	In addition, pharmacological activation of the Nrf2 signaling pathway by small molecule inducers such as SFN attenuated oxidative stress and neuronal damage following TBI.	sulforaphane	105-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51
20688330-11	2010	CONCLUSIONS: Collectively, these results indicate that SFN inhibits EL expression via inhibition of NF-kappaB which may have a beneficial effect on HDL cholesterol levels.	sulforaphane	55-58	lipase G, endothelial type	Homo sapiens	68-70
20688330-11	2010	CONCLUSIONS: Collectively, these results indicate that SFN inhibits EL expression via inhibition of NF-kappaB which may have a beneficial effect on HDL cholesterol levels.	sulforaphane	55-58	nuclear factor kappa B subunit 1	Homo sapiens	100-109
20688330-0	2010	Sulforaphane inhibits endothelial lipase expression through NF-kappaB in endothelial cells.	sulforaphane	0-12	lipase G, endothelial type	Homo sapiens	22-40
21116791-0	2010	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kappaB in human keratinocytes.	sulforaphane	0-12	C-C motif chemokine ligand 17	Homo sapiens	24-28
20688330-0	2010	Sulforaphane inhibits endothelial lipase expression through NF-kappaB in endothelial cells.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	60-69
21116791-0	2010	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kappaB in human keratinocytes.	sulforaphane	0-12	C-C motif chemokine ligand 17	Homo sapiens	29-34
20833711-0	2010	Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27.	sulforaphane	0-12	heat shock protein family B (small) member 1	Homo sapiens	101-106
21116791-0	2010	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kappaB in human keratinocytes.	sulforaphane	0-12	C-C motif chemokine ligand 22	Homo sapiens	39-42
20833711-4	2010	Specifically, SFN-induced expression of heat shock protein 27 (Hsp27) underlies SFN-stimulated proteasome activity.	sulforaphane	14-17	heat shock protein family B (small) member 1	Homo sapiens	40-61
21116791-0	2010	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kappaB in human keratinocytes.	sulforaphane	0-12	C-C motif chemokine ligand 22	Homo sapiens	43-48
20833711-4	2010	Specifically, SFN-induced expression of heat shock protein 27 (Hsp27) underlies SFN-stimulated proteasome activity.	sulforaphane	14-17	heat shock protein family B (small) member 1	Homo sapiens	63-68
21116791-0	2010	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kappaB in human keratinocytes.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	68-84
20833711-4	2010	Specifically, SFN-induced expression of heat shock protein 27 (Hsp27) underlies SFN-stimulated proteasome activity.	sulforaphane	80-83	heat shock protein family B (small) member 1	Homo sapiens	40-61
20833711-4	2010	Specifically, SFN-induced expression of heat shock protein 27 (Hsp27) underlies SFN-stimulated proteasome activity.	sulforaphane	80-83	heat shock protein family B (small) member 1	Homo sapiens	63-68
21116791-0	2010	Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-kappaB in human keratinocytes.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	89-98
20833711-5	2010	SFN-induced proteasome activity was significantly enhanced in Hsp27-overexpressing cells but absent in Hsp27-silenced cells.	sulforaphane	0-3	heat shock protein family B (small) member 1	Homo sapiens	62-67
21116791-1	2010	Sulforaphane (4-methylsulfinylbutyl isothiocyanate, SFN) from broccoli has been used a chemopreventive photochemical as detoxification of xenobiotics and anti-inflammatory, however, there is no studies for Th2 chemokine expression through heme oxygenase-1 and NF-kappaB in keratinocytes.	sulforaphane	0-12	RNA exonuclease 2	Homo sapiens	52-55
20833711-5	2010	SFN-induced proteasome activity was significantly enhanced in Hsp27-overexpressing cells but absent in Hsp27-silenced cells.	sulforaphane	0-3	heat shock protein family B (small) member 1	Homo sapiens	103-108
20833711-6	2010	The role of Hsp27 in regulating proteasome activity was further confirmed in isogenic REG cells, in which SFN-induced proteasome activation was only observed in cells stably overexpressing Hsp27, but not in the Hsp27-free parental cells.	sulforaphane	106-109	heat shock protein family B (small) member 1	Homo sapiens	12-17
21116791-1	2010	Sulforaphane (4-methylsulfinylbutyl isothiocyanate, SFN) from broccoli has been used a chemopreventive photochemical as detoxification of xenobiotics and anti-inflammatory, however, there is no studies for Th2 chemokine expression through heme oxygenase-1 and NF-kappaB in keratinocytes.	sulforaphane	0-12	heme oxygenase 1	Homo sapiens	239-255
20833711-6	2010	The role of Hsp27 in regulating proteasome activity was further confirmed in isogenic REG cells, in which SFN-induced proteasome activation was only observed in cells stably overexpressing Hsp27, but not in the Hsp27-free parental cells.	sulforaphane	106-109	heat shock protein family B (small) member 1	Homo sapiens	189-194
21116791-1	2010	Sulforaphane (4-methylsulfinylbutyl isothiocyanate, SFN) from broccoli has been used a chemopreventive photochemical as detoxification of xenobiotics and anti-inflammatory, however, there is no studies for Th2 chemokine expression through heme oxygenase-1 and NF-kappaB in keratinocytes.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	260-269
20833711-6	2010	The role of Hsp27 in regulating proteasome activity was further confirmed in isogenic REG cells, in which SFN-induced proteasome activation was only observed in cells stably overexpressing Hsp27, but not in the Hsp27-free parental cells.	sulforaphane	106-109	heat shock protein family B (small) member 1	Homo sapiens	189-194
20833711-9	2010	This is the first report to show that heat shock response by SFN, in addition to the antioxidant response mediated by the Keap1-Nrf2 pathway, may contribute to cytoprotection.	sulforaphane	61-64	NFE2 like bZIP transcription factor 2	Homo sapiens	128-132
21116791-1	2010	Sulforaphane (4-methylsulfinylbutyl isothiocyanate, SFN) from broccoli has been used a chemopreventive photochemical as detoxification of xenobiotics and anti-inflammatory, however, there is no studies for Th2 chemokine expression through heme oxygenase-1 and NF-kappaB in keratinocytes.	sulforaphane	14-50	heme oxygenase 1	Homo sapiens	239-255
21116791-1	2010	Sulforaphane (4-methylsulfinylbutyl isothiocyanate, SFN) from broccoli has been used a chemopreventive photochemical as detoxification of xenobiotics and anti-inflammatory, however, there is no studies for Th2 chemokine expression through heme oxygenase-1 and NF-kappaB in keratinocytes.	sulforaphane	14-50	nuclear factor kappa B subunit 1	Homo sapiens	260-269
20810543-5	2010	Moreover, Nrf2 activation by SF in the bladder occurs primarily in the epithelium, which is the principal site of bladder cancer development.	sulforaphane	29-31	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
20603835-10	2010	The coherency of these results was further confirmed by using TGF-beta receptor kinase inhibitor SB431542, which largely abolishes inhibitory effects of SFN on both, ODC activity and cell growth.	sulforaphane	153-156	transforming growth factor beta 1	Homo sapiens	62-70
22993618-0	2010	Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9.	sulforaphane	14-26	matrix metallopeptidase 9	Mus musculus	110-136
20806931-6	2010	CBR3 mRNA could be induced in HT-29 cells by Nrf2 agonists [sulforaphane (SUL, 7-fold) and diethyl maleate (DEM, 4-fold)] or hormone receptor ligand Z-guggulsterone (5-fold).	sulforaphane	60-72	carbonyl reductase 3	Homo sapiens	0-4
20806931-6	2010	CBR3 mRNA could be induced in HT-29 cells by Nrf2 agonists [sulforaphane (SUL, 7-fold) and diethyl maleate (DEM, 4-fold)] or hormone receptor ligand Z-guggulsterone (5-fold).	sulforaphane	60-72	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
20868228-5	2010	We therefore investigated myrosinase-treated GRA, nGBS and synthetic SFN for their ability to induce NAD(P)H:quinone oxidoreductase 1 (NQO1) as typical phase 2 enzyme, and glutathione peroxidase 2 (GPx2) as novel Nrf2 target in HepG2 cells.	sulforaphane	69-72	NAD(P)H quinone dehydrogenase 1	Homo sapiens	101-133
20868228-5	2010	We therefore investigated myrosinase-treated GRA, nGBS and synthetic SFN for their ability to induce NAD(P)H:quinone oxidoreductase 1 (NQO1) as typical phase 2 enzyme, and glutathione peroxidase 2 (GPx2) as novel Nrf2 target in HepG2 cells.	sulforaphane	69-72	NAD(P)H quinone dehydrogenase 1	Homo sapiens	135-139
20868228-5	2010	We therefore investigated myrosinase-treated GRA, nGBS and synthetic SFN for their ability to induce NAD(P)H:quinone oxidoreductase 1 (NQO1) as typical phase 2 enzyme, and glutathione peroxidase 2 (GPx2) as novel Nrf2 target in HepG2 cells.	sulforaphane	69-72	glutathione peroxidase 2	Homo sapiens	172-196
20868228-5	2010	We therefore investigated myrosinase-treated GRA, nGBS and synthetic SFN for their ability to induce NAD(P)H:quinone oxidoreductase 1 (NQO1) as typical phase 2 enzyme, and glutathione peroxidase 2 (GPx2) as novel Nrf2 target in HepG2 cells.	sulforaphane	69-72	glutathione peroxidase 2	Homo sapiens	198-202
20868228-5	2010	We therefore investigated myrosinase-treated GRA, nGBS and synthetic SFN for their ability to induce NAD(P)H:quinone oxidoreductase 1 (NQO1) as typical phase 2 enzyme, and glutathione peroxidase 2 (GPx2) as novel Nrf2 target in HepG2 cells.	sulforaphane	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	213-217
20947810-0	2010	Sulforaphane attenuates matrix metalloproteinase-9 expression following spinal cord injury in mice.	sulforaphane	0-12	matrix metallopeptidase 9	Mus musculus	24-50
20947810-2	2010	The present study explored the effect of sulforaphane (SFN), a potent anti-inflammatory extract of cruciferous vegetables, on the expression of two inflammatory mediators, metalloproteinase (MMP)-9 and TNF-alpha, in a murine model of SCI.	sulforaphane	41-53	matrix metallopeptidase 9	Mus musculus	172-197
20947810-2	2010	The present study explored the effect of sulforaphane (SFN), a potent anti-inflammatory extract of cruciferous vegetables, on the expression of two inflammatory mediators, metalloproteinase (MMP)-9 and TNF-alpha, in a murine model of SCI.	sulforaphane	41-53	tumor necrosis factor	Mus musculus	202-211
20947810-2	2010	The present study explored the effect of sulforaphane (SFN), a potent anti-inflammatory extract of cruciferous vegetables, on the expression of two inflammatory mediators, metalloproteinase (MMP)-9 and TNF-alpha, in a murine model of SCI.	sulforaphane	55-58	matrix metallopeptidase 9	Mus musculus	172-197
20947810-2	2010	The present study explored the effect of sulforaphane (SFN), a potent anti-inflammatory extract of cruciferous vegetables, on the expression of two inflammatory mediators, metalloproteinase (MMP)-9 and TNF-alpha, in a murine model of SCI.	sulforaphane	55-58	tumor necrosis factor	Mus musculus	202-211
20947810-8	2010	The decrease of MMP-9 in mice treated with SFN was associated with decreased levels of spinal cord water content and TNF-alpha.	sulforaphane	43-46	matrix metallopeptidase 9	Mus musculus	16-21
20947810-8	2010	The decrease of MMP-9 in mice treated with SFN was associated with decreased levels of spinal cord water content and TNF-alpha.	sulforaphane	43-46	tumor necrosis factor	Mus musculus	117-126
20603835-10	2010	The coherency of these results was further confirmed by using TGF-beta receptor kinase inhibitor SB431542, which largely abolishes inhibitory effects of SFN on both, ODC activity and cell growth.	sulforaphane	153-156	ornithine decarboxylase 1	Homo sapiens	166-169
20603835-11	2010	CONCLUSION: Since elevated ODC enzyme activity is associated with enhanced tumor development, SFN may be a dietary phytochemical with potential to prevent carcinogenesis.	sulforaphane	94-97	ornithine decarboxylase 1	Homo sapiens	27-30
20451318-4	2010	We suggest that elevated intracellular reactive oxygen species (ROS) levels, due to exposure to SFN, has a critical role in abolishing since pretreatment with NAC, an antioxidant, resulted in the recovery of hTERT expression.	sulforaphane	96-99	synuclein alpha	Homo sapiens	159-162
20600671-7	2010	However, sulforaphane could upregulate the expression of HO-1 and NAD(P)H/quinone oxidoreductase-1 (NQO-1) in cells transfected with the empty vector and the wild-type TDP-43.	sulforaphane	9-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	100-105
20600671-7	2010	However, sulforaphane could upregulate the expression of HO-1 and NAD(P)H/quinone oxidoreductase-1 (NQO-1) in cells transfected with the empty vector and the wild-type TDP-43.	sulforaphane	9-21	TAR DNA binding protein	Homo sapiens	168-174
20600671-8	2010	Thus, sulforaphane protected cells against mutant TDP-43 independent of Nrf2-antioxidant response element (ARE) pathway.	sulforaphane	6-18	TAR DNA binding protein	Homo sapiens	50-56
20600671-9	2010	How mutant TDP-43 reduces expression of HO-1 and prevents sulforaphane from activating Nrf2 signaling remains to be investigated.	sulforaphane	58-70	TAR DNA binding protein	Homo sapiens	11-17
20600671-9	2010	How mutant TDP-43 reduces expression of HO-1 and prevents sulforaphane from activating Nrf2 signaling remains to be investigated.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
20599909-5	2010	Indeed, we found that similar to the known phase II inducer sulforaphane, the heteroaromatic 4-arylquinols PMX290 and PMX464 increase both Nrf2 protein concentrations and transcriptional activity.	sulforaphane	60-72	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
20599909-8	2010	While sulforaphane was found to decrease binding of Cullin3 to Keap1, PMX290 markedly increased the interaction between these two proteins in intact cells.	sulforaphane	6-18	cullin 3	Homo sapiens	52-59
20599909-8	2010	While sulforaphane was found to decrease binding of Cullin3 to Keap1, PMX290 markedly increased the interaction between these two proteins in intact cells.	sulforaphane	6-18	kelch like ECH associated protein 1	Homo sapiens	63-68
20600671-6	2010	Nevertheless, sulforaphane reduced the level of lactate dehydrogenase and lipoperoxidation products in cells expressing TDP-43 mutant.	sulforaphane	14-26	TAR DNA binding protein	Homo sapiens	120-126
20600671-7	2010	However, sulforaphane could upregulate the expression of HO-1 and NAD(P)H/quinone oxidoreductase-1 (NQO-1) in cells transfected with the empty vector and the wild-type TDP-43.	sulforaphane	9-21	heme oxygenase 1	Homo sapiens	57-61
20600671-7	2010	However, sulforaphane could upregulate the expression of HO-1 and NAD(P)H/quinone oxidoreductase-1 (NQO-1) in cells transfected with the empty vector and the wild-type TDP-43.	sulforaphane	9-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	66-98
20729872-0	2010	Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.	sulforaphane	88-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	14-18
20729872-0	2010	Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.	sulforaphane	88-100	jun proto-oncogene	Mus musculus	24-28
20729872-0	2010	Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells.	sulforaphane	88-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
20729872-1	2010	AIM: To examine the regulatory crosstalk between the transcription factors Nrf2 and AP-1 in prostate cancer (PCa) by dietary cancer chemopreventive compounds (-)epigallocatechin-3-gallate (EGCG) from green tea and sulforaphane (SFN) from cruciferous vegetables.	sulforaphane	214-226	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
20729872-1	2010	AIM: To examine the regulatory crosstalk between the transcription factors Nrf2 and AP-1 in prostate cancer (PCa) by dietary cancer chemopreventive compounds (-)epigallocatechin-3-gallate (EGCG) from green tea and sulforaphane (SFN) from cruciferous vegetables.	sulforaphane	228-231	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
20729872-3	2010	RESULTS: Our study shows that AP-1 activation was attenuated by the combinations of SFN (25 micromol/L) and EGCG (20 or 100 micromol/L) in PC-3 cells.	sulforaphane	84-87	jun proto-oncogene	Mus musculus	30-34
20729872-4	2010	Several key Nrf2-dependent genes were down-regulated (3-fold to 35-fold) after in vivo administration of the combination of EGCG (100 mg/kg) and SFN (45 mg/kg).	sulforaphane	145-148	nuclear factor, erythroid derived 2, like 2	Mus musculus	12-16
20729872-6	2010	CONCLUSION: Taken together, our present study of transcriptome profiling the gene expression changes induced by dietary phytochemicals SFN and EGCG in Nrf2-deficient mice and in PC-3 cells in vitro demonstrates that the effects of SFN+EGCG could be mediated via concerted modulation of Nrf2 and AP-1 pathways in the prostate.	sulforaphane	135-138	nuclear factor, erythroid derived 2, like 2	Mus musculus	151-155
20729872-6	2010	CONCLUSION: Taken together, our present study of transcriptome profiling the gene expression changes induced by dietary phytochemicals SFN and EGCG in Nrf2-deficient mice and in PC-3 cells in vitro demonstrates that the effects of SFN+EGCG could be mediated via concerted modulation of Nrf2 and AP-1 pathways in the prostate.	sulforaphane	135-138	jun proto-oncogene	Mus musculus	295-299
20451318-4	2010	We suggest that elevated intracellular reactive oxygen species (ROS) levels, due to exposure to SFN, has a critical role in abolishing since pretreatment with NAC, an antioxidant, resulted in the recovery of hTERT expression.	sulforaphane	96-99	telomerase reverse transcriptase	Homo sapiens	208-213
20451318-5	2010	SFN also suppressed the phosphorylation of Akt (Ser-473), thereby inhibiting hTERT phosphorylation and this effect was reversed by pretreatment with NAC.	sulforaphane	0-3	AKT serine/threonine kinase 1	Homo sapiens	43-46
20451318-5	2010	SFN also suppressed the phosphorylation of Akt (Ser-473), thereby inhibiting hTERT phosphorylation and this effect was reversed by pretreatment with NAC.	sulforaphane	0-3	telomerase reverse transcriptase	Homo sapiens	77-82
20451318-5	2010	SFN also suppressed the phosphorylation of Akt (Ser-473), thereby inhibiting hTERT phosphorylation and this effect was reversed by pretreatment with NAC.	sulforaphane	0-3	synuclein alpha	Homo sapiens	149-152
20600217-0	2010	Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
20944112-6	2010	In MDA-MB-231 cells, 30 muM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels.	sulforaphane	28-31	cyclin dependent kinase inhibitor 1B	Homo sapiens	106-113
20944112-6	2010	In MDA-MB-231 cells, 30 muM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels.	sulforaphane	28-31	cyclin A2	Homo sapiens	135-143
20944112-6	2010	In MDA-MB-231 cells, 30 muM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels.	sulforaphane	28-31	cyclin B1	Homo sapiens	145-154
20944112-6	2010	In MDA-MB-231 cells, 30 muM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels.	sulforaphane	28-31	cyclin dependent kinase 1	Homo sapiens	159-163
20944112-8	2010	In addition, the SFN-treated cells exhibited autophagy, as characterized by the appearance of autophagic vacuoles by electron microscopy, the accumulation of acidic vesicular organelles by flow cytometry, and the punctuate patterns of microtubule-associated protein 1 light chain 3 (LC3) by fluorescein microscopy.	sulforaphane	17-20	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	283-286
20944112-10	2010	Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim).	sulforaphane	81-84	BCL2 associated X, apoptosis regulator	Homo sapiens	170-173
20944112-10	2010	Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim).	sulforaphane	81-84	caspase 3	Homo sapiens	194-203
20944112-10	2010	Treatment with autophagy inhibitor bafilomycin A1 (but not 3-methyladenine) with SFN significantly enhanced apoptosis, which was accompanied by increases in the level of BAX and the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP)-1 and decreases in the mitochondrial membrane potential (DeltaPsim).	sulforaphane	81-84	poly(ADP-ribose) polymerase 1	Homo sapiens	208-243
20600217-10	2010	SFN-induced protective response was mediated through Nrf2 pathway.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	53-57
20417626-0	2010	Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	82-86
21793331-8	2010	Collectively, in MDCK cells, sulforaphane induced [Ca2+]i rises by causing Ca2+ entry through phospholipase A2-sensitive pathways without inducing Ca2+ release from the endoplasmic reticulum.	sulforaphane	29-41	phospholipase A2 group IB	Canis lupus familiaris	94-110
20442190-0	2010	Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.	sulforaphane	0-12	glutathione S-transferase mu 1	Homo sapiens	130-135
20442190-0	2010	Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression.	sulforaphane	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155
20442190-7	2010	Transcriptional repression of genes involved in AFB bioactivation (CYP3A4 and CYP1A2), but not transcriptional activation of GSTs, may be responsible for the protective effects of SFN.	sulforaphane	180-183	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-73
20442190-7	2010	Transcriptional repression of genes involved in AFB bioactivation (CYP3A4 and CYP1A2), but not transcriptional activation of GSTs, may be responsible for the protective effects of SFN.	sulforaphane	180-183	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	78-84
20442190-9	2010	The downregulation of CYP3A4 by SFN may have important implications for drug interactions.	sulforaphane	32-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	22-28
20626841-2	2010	In this study, we investigate the interaction between sulforaphane, a dietary isothiocyanate derived from broccoli, PTEN expression and gene expression in pre malignant prostate tissue.	sulforaphane	54-66	phosphatase and tensin homolog	Mus musculus	116-120
20626841-4	2010	We subsequently use the mouse prostate-specific PTEN deletion model, to show that sulforaphane suppresses transcriptional changes induced by PTEN deletion and induces additional changes in gene expression associated with cell cycle arrest and apoptosis in PTEN null tissue, but has no effect on transcription in wild type tissue.	sulforaphane	82-94	phosphatase and tensin homolog	Mus musculus	48-52
20626841-4	2010	We subsequently use the mouse prostate-specific PTEN deletion model, to show that sulforaphane suppresses transcriptional changes induced by PTEN deletion and induces additional changes in gene expression associated with cell cycle arrest and apoptosis in PTEN null tissue, but has no effect on transcription in wild type tissue.	sulforaphane	82-94	phosphatase and tensin homolog	Mus musculus	141-145
20626841-4	2010	We subsequently use the mouse prostate-specific PTEN deletion model, to show that sulforaphane suppresses transcriptional changes induced by PTEN deletion and induces additional changes in gene expression associated with cell cycle arrest and apoptosis in PTEN null tissue, but has no effect on transcription in wild type tissue.	sulforaphane	82-94	phosphatase and tensin homolog	Mus musculus	141-145
20626841-6	2010	Global analyses of exon expression demonstrated that sulforaphane interacts with PTEN deletion to modulate alternative gene splicing, illustrated through a more detailed analysis of DMBT1 splicing.	sulforaphane	53-65	phosphatase and tensin homolog	Mus musculus	81-85
20626841-6	2010	Global analyses of exon expression demonstrated that sulforaphane interacts with PTEN deletion to modulate alternative gene splicing, illustrated through a more detailed analysis of DMBT1 splicing.	sulforaphane	53-65	deleted in malignant brain tumors 1	Mus musculus	182-187
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	14-17	heme oxygenase 1	Rattus norvegicus	213-229
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	14-17	heme oxygenase 1	Rattus norvegicus	231-235
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	253-257
20417626-7	2010	SFN pretreatment increased the expression of Nrf2 and HO-1 in the brain and reduced infarct ratio at 24h after HI.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	45-49
20417626-7	2010	SFN pretreatment increased the expression of Nrf2 and HO-1 in the brain and reduced infarct ratio at 24h after HI.	sulforaphane	0-3	heme oxygenase 1	Rattus norvegicus	54-58
20417626-8	2010	The number of TUNEL-positive neurons as well as activated macroglia and the amount of 8OH-dG, were markedly reduced after SFN treatment, accompanied by suppressed caspase-3 activity and reduced lipid peroxidation (MDA) level.	sulforaphane	122-125	caspase 3	Rattus norvegicus	163-172
20722931-6	2010	Liver expression of CYP1A1 and epoxide hydrolase, measured using real-time PCR, was correlated with the plasma concentration of sulforaphane.	sulforaphane	128-140	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	20-26
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-176
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	178-182
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	213-229
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	231-235
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	253-257
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-176
20417626-2	2010	Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has cytoprotective effects against oxidative stress and its effect was mediated by NF-E2-related factor-2 (Nrf2), a transcription factor, and heme oxygenase 1 (HO-1) which is one of Nrf2 downstream target genes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	178-182
20625516-0	2010	Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.	sulforaphane	0-12	telomerase reverse transcriptase	Homo sapiens	45-50
20625516-6	2010	DNA methyltransferases (DNMTs), especially DNMT1 and DNMT3a, were also decreased in SFN-treated breast cancer cells suggesting that SFN may repress hTERT by impacting epigenetic pathways.	sulforaphane	84-87	DNA methyltransferase 1	Homo sapiens	43-48
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	H3 histone pseudogene 16	Homo sapiens	30-33
20625516-6	2010	DNA methyltransferases (DNMTs), especially DNMT1 and DNMT3a, were also decreased in SFN-treated breast cancer cells suggesting that SFN may repress hTERT by impacting epigenetic pathways.	sulforaphane	84-87	DNA methyltransferase 3 alpha	Homo sapiens	53-59
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	34-38
20625516-6	2010	DNA methyltransferases (DNMTs), especially DNMT1 and DNMT3a, were also decreased in SFN-treated breast cancer cells suggesting that SFN may repress hTERT by impacting epigenetic pathways.	sulforaphane	84-87	telomerase reverse transcriptase	Homo sapiens	148-153
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	interferon alpha inducible protein 27	Homo sapiens	43-46
20625516-7	2010	Down-regulation of DNMTs in response to SFN induced site-specific CpG demethylation occurring primarily in the first exon of the hTERT gene thereby facilitating CTCF binding associated with hTERT repression.	sulforaphane	40-43	telomerase reverse transcriptase	Homo sapiens	129-134
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	cyclin dependent kinase inhibitor 1B	Homo sapiens	47-51
20642839-7	2010	SFN induced the expression of p21/CIP1 and p27/KIP1, and inhibited the expression of cyclin D1.	sulforaphane	0-3	cyclin D1	Homo sapiens	85-94
20625516-7	2010	Down-regulation of DNMTs in response to SFN induced site-specific CpG demethylation occurring primarily in the first exon of the hTERT gene thereby facilitating CTCF binding associated with hTERT repression.	sulforaphane	40-43	CCCTC-binding factor	Homo sapiens	161-165
20625516-7	2010	Down-regulation of DNMTs in response to SFN induced site-specific CpG demethylation occurring primarily in the first exon of the hTERT gene thereby facilitating CTCF binding associated with hTERT repression.	sulforaphane	40-43	telomerase reverse transcriptase	Homo sapiens	190-195
20625516-9	2010	SFN-induced hyperacetylation facilitated the binding of many hTERT repressor proteins such as MAD1 and CTCF to the hTERT regulatory region.	sulforaphane	0-3	telomerase reverse transcriptase	Homo sapiens	61-66
20625516-9	2010	SFN-induced hyperacetylation facilitated the binding of many hTERT repressor proteins such as MAD1 and CTCF to the hTERT regulatory region.	sulforaphane	0-3	MAX dimerization protein 1	Homo sapiens	94-98
20625516-9	2010	SFN-induced hyperacetylation facilitated the binding of many hTERT repressor proteins such as MAD1 and CTCF to the hTERT regulatory region.	sulforaphane	0-3	CCCTC-binding factor	Homo sapiens	103-107
20625516-9	2010	SFN-induced hyperacetylation facilitated the binding of many hTERT repressor proteins such as MAD1 and CTCF to the hTERT regulatory region.	sulforaphane	0-3	telomerase reverse transcriptase	Homo sapiens	115-120
20625516-10	2010	Depletion of CTCF using siRNA reduced the SFN-induced down-regulation of hTERT mRNA transcription in these breast cancer cells.	sulforaphane	42-45	CCCTC-binding factor	Homo sapiens	13-17
20625516-10	2010	Depletion of CTCF using siRNA reduced the SFN-induced down-regulation of hTERT mRNA transcription in these breast cancer cells.	sulforaphane	42-45	telomerase reverse transcriptase	Homo sapiens	73-78
20818711-4	2010	SFN induced the expression of GST A3, GST A4, GST M1, GST P1, and GST T1 in alpha mouse line (AML) 12 cells.	sulforaphane	0-3	glutathione S-transferase, alpha 3	Mus musculus	30-52
20818711-4	2010	SFN induced the expression of GST A3, GST A4, GST M1, GST P1, and GST T1 in alpha mouse line (AML) 12 cells.	sulforaphane	0-3	glutathione S-transferase, pi 1	Mus musculus	54-60
20818711-4	2010	SFN induced the expression of GST A3, GST A4, GST M1, GST P1, and GST T1 in alpha mouse line (AML) 12 cells.	sulforaphane	0-3	glutathione S-transferase, theta 1	Mus musculus	66-72
20405237-10	2010	Taken together, these data indicated that sulforaphane exhibited the protective role against the inflammatory injury in vascular endothelia cells, through inactivating p38 MAPK and JNK, as well as inducing phase 2 enzymes.	sulforaphane	42-54	mitogen-activated protein kinase 8	Homo sapiens	181-184
20572303-0	2010	Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-90
20572303-1	2010	AIM: To investigate the effect of sulforaphane (SFN) on regulation of NF-E2-related factor-2 (Nrf2)-antioxidant response element (ARE) pathway in liver injury induced by intestinal ischemia/reperfusion (I/R).	sulforaphane	34-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-92
20572303-1	2010	AIM: To investigate the effect of sulforaphane (SFN) on regulation of NF-E2-related factor-2 (Nrf2)-antioxidant response element (ARE) pathway in liver injury induced by intestinal ischemia/reperfusion (I/R).	sulforaphane	34-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98
20572303-1	2010	AIM: To investigate the effect of sulforaphane (SFN) on regulation of NF-E2-related factor-2 (Nrf2)-antioxidant response element (ARE) pathway in liver injury induced by intestinal ischemia/reperfusion (I/R).	sulforaphane	48-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-92
20572303-1	2010	AIM: To investigate the effect of sulforaphane (SFN) on regulation of NF-E2-related factor-2 (Nrf2)-antioxidant response element (ARE) pathway in liver injury induced by intestinal ischemia/reperfusion (I/R).	sulforaphane	48-51	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98
20405237-4	2010	The results showed that sulforaphane inhibited the expression of COX-2 and iNOS stimulated by lipopolysaccharide in a dose- and time-dependent manner.	sulforaphane	24-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	65-70
20405237-4	2010	The results showed that sulforaphane inhibited the expression of COX-2 and iNOS stimulated by lipopolysaccharide in a dose- and time-dependent manner.	sulforaphane	24-36	inositol-3-phosphate synthase 1	Homo sapiens	75-79
20237067-0	2010	Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation.	sulforaphane	0-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	80-105
20405237-5	2010	Moreover, sulforaphane suppressed the phosphorylation of ERK1/2, JNK, and p38 activated by lipopolysaccharide.	sulforaphane	10-22	mitogen-activated protein kinase 3	Homo sapiens	57-63
20405237-5	2010	Moreover, sulforaphane suppressed the phosphorylation of ERK1/2, JNK, and p38 activated by lipopolysaccharide.	sulforaphane	10-22	mitogen-activated protein kinase 8	Homo sapiens	65-68
20405237-5	2010	Moreover, sulforaphane suppressed the phosphorylation of ERK1/2, JNK, and p38 activated by lipopolysaccharide.	sulforaphane	10-22	mitogen-activated protein kinase 1	Homo sapiens	74-77
20405237-8	2010	Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane.	sulforaphane	145-157	mitogen-activated protein kinase 1	Homo sapiens	61-64
20405237-8	2010	Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane.	sulforaphane	145-157	mitogen-activated protein kinase 8	Homo sapiens	69-72
20405237-8	2010	Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane.	sulforaphane	145-157	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	108-113
20405237-8	2010	Moreover, pretreatment with anisomycin (AM), an activator of p38 and JNK, instead of LPS, the expression of COX-2 and iNOS is still inhibited by sulforaphane.	sulforaphane	145-157	inositol-3-phosphate synthase 1	Homo sapiens	118-122
20405237-10	2010	Taken together, these data indicated that sulforaphane exhibited the protective role against the inflammatory injury in vascular endothelia cells, through inactivating p38 MAPK and JNK, as well as inducing phase 2 enzymes.	sulforaphane	42-54	mitogen-activated protein kinase 1	Homo sapiens	168-171
20405237-10	2010	Taken together, these data indicated that sulforaphane exhibited the protective role against the inflammatory injury in vascular endothelia cells, through inactivating p38 MAPK and JNK, as well as inducing phase 2 enzymes.	sulforaphane	42-54	mitogen-activated protein kinase 3	Homo sapiens	172-176
19924513-2	2010	Additionally, we investigated the effects of SF and LPS on the activity of Nrf2.	sulforaphane	45-47	NFE2 like bZIP transcription factor 2	Rattus norvegicus	75-79
19924513-13	2010	Moreover, SF and LPS together are able to induce Nrf2 activation.	sulforaphane	10-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	49-53
20200220-10	2010	In addition, we found that coexposure with sulforaphane, an Nrf2 activator, could significantly protect against PFOS-induced ROS generation, whereas inhibition of MAPKs did not exhibit significant effects on PFOS-induced HO-1 gene expression and ROS production.	sulforaphane	43-55	nfe2 like bZIP transcription factor 2a	Danio rerio	60-64
20439747-2	2010	The mechanism of action of sulforaphane is believed to involve modifications of critical cysteine residues of Keap1, which lead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.	sulforaphane	27-39	kelch-like ECH-associated protein 1	Mus musculus	110-115
20439747-2	2010	The mechanism of action of sulforaphane is believed to involve modifications of critical cysteine residues of Keap1, which lead to stabilization of Nrf2 to activate the antioxidant response element of phase 2 enzymes.	sulforaphane	27-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152
20439747-3	2010	However, the dithiocarbamate functional group formed by a reversible reaction between isothiocyanate of sulforaphane and sulfhydryl nucleophiles of Keap1 is kinetically labile, and such modification in intact cells has not yet been demonstrated.	sulforaphane	104-116	kelch-like ECH-associated protein 1	Mus musculus	148-153
20202476-7	2010	Trx levels were undetectable in Nrf2-deficient mouse embryo fibroblasts (MEFs), whereas they were constitutively high in Keap1-deficient MEFs as well as in SH-SY5Y cells treated with sulforaphane (SFN).	sulforaphane	183-195	thioredoxin 1	Mus musculus	0-3
20202476-7	2010	Trx levels were undetectable in Nrf2-deficient mouse embryo fibroblasts (MEFs), whereas they were constitutively high in Keap1-deficient MEFs as well as in SH-SY5Y cells treated with sulforaphane (SFN).	sulforaphane	197-200	thioredoxin 1	Mus musculus	0-3
20486933-5	2010	To identify chemical modulator targeting the IVR domain of Keap1, we built a 3D structural model of the Keap1 IVR domain and demonstrated this structural model is effective in retrieving novel Nrf2 inducers from chemical databases, BM10, 31, and 40 increase concentration of nuclear Nrf2, with a potency comparable to that of sulforaphane.	sulforaphane	326-338	kelch like ECH associated protein 1	Homo sapiens	59-64
20486933-5	2010	To identify chemical modulator targeting the IVR domain of Keap1, we built a 3D structural model of the Keap1 IVR domain and demonstrated this structural model is effective in retrieving novel Nrf2 inducers from chemical databases, BM10, 31, and 40 increase concentration of nuclear Nrf2, with a potency comparable to that of sulforaphane.	sulforaphane	326-338	kelch like ECH associated protein 1	Homo sapiens	104-109
20486933-5	2010	To identify chemical modulator targeting the IVR domain of Keap1, we built a 3D structural model of the Keap1 IVR domain and demonstrated this structural model is effective in retrieving novel Nrf2 inducers from chemical databases, BM10, 31, and 40 increase concentration of nuclear Nrf2, with a potency comparable to that of sulforaphane.	sulforaphane	326-338	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
19998483-4	2010	In this study, we tested the hypothesis that sulforaphane (SFP), a naturally occurring isothiocyanate that is also a known activator of the ARE/Nrf2 antioxidant pathway, can protect immature neurons from oxidative stress-induced death.	sulforaphane	45-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
19998483-4	2010	In this study, we tested the hypothesis that sulforaphane (SFP), a naturally occurring isothiocyanate that is also a known activator of the ARE/Nrf2 antioxidant pathway, can protect immature neurons from oxidative stress-induced death.	sulforaphane	59-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
20216230-10	2010	Pretreatment with the potent Nrf2 activator sulforaphane had the reverse effect.	sulforaphane	44-56	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
20388854-9	2010	Western blotting analysis and beta-catenin reporter assay showed that sulforaphane downregulated the Wnt/beta-catenin self-renewal pathway.	sulforaphane	70-82	catenin (cadherin associated protein), beta 1	Mus musculus	30-42
20388854-9	2010	Western blotting analysis and beta-catenin reporter assay showed that sulforaphane downregulated the Wnt/beta-catenin self-renewal pathway.	sulforaphane	70-82	catenin (cadherin associated protein), beta 1	Mus musculus	105-117
20388854-10	2010	CONCLUSIONS: Sulforaphane inhibits breast CSCs and downregulates the Wnt/beta-catenin self-renewal pathway.	sulforaphane	13-25	catenin (cadherin associated protein), beta 1	Mus musculus	73-85
20237067-0	2010	Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-128
20237067-3	2010	Here, we examined the modulatory effect of sulforaphane (SFN) and alpha-lipoic acid (LA) or dihydrolipoic acid (DHLA) on GSTP expression in rat Clone 9 liver cells.	sulforaphane	43-55	glutathione S-transferase pi 1	Rattus norvegicus	121-125
20237067-6	2010	The increase in GSTP enzyme activity in cells treated with 5 micromol/L SFN, 50 micromol/L DATS, and 600 micromol/L LA and DHLA was 172, 75, 122, and 117%, respectively (P < 0.05).	sulforaphane	72-75	glutathione S-transferase pi 1	Rattus norvegicus	16-20
20096777-4	2010	Pretreatment of rat tubular epithelial NRK-52E cells with sulforaphane, an activator of NRF2, could prevent EMT gene changes such as the loss of E-cadherin and the increase in alpha-smooth muscle actin (alpha-SMA) expression.	sulforaphane	58-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	88-92
20096777-4	2010	Pretreatment of rat tubular epithelial NRK-52E cells with sulforaphane, an activator of NRF2, could prevent EMT gene changes such as the loss of E-cadherin and the increase in alpha-smooth muscle actin (alpha-SMA) expression.	sulforaphane	58-70	cadherin 1	Rattus norvegicus	145-155
20096777-4	2010	Pretreatment of rat tubular epithelial NRK-52E cells with sulforaphane, an activator of NRF2, could prevent EMT gene changes such as the loss of E-cadherin and the increase in alpha-smooth muscle actin (alpha-SMA) expression.	sulforaphane	58-70	actin gamma 2, smooth muscle	Rattus norvegicus	176-201
20096777-4	2010	Pretreatment of rat tubular epithelial NRK-52E cells with sulforaphane, an activator of NRF2, could prevent EMT gene changes such as the loss of E-cadherin and the increase in alpha-smooth muscle actin (alpha-SMA) expression.	sulforaphane	58-70	actin gamma 2, smooth muscle	Rattus norvegicus	203-212
20205397-1	2010	D,L-sulforaphane (SFN), a synthetic analogue of the broccoli-derived l-isomer, is a highly promising cancer chemopreventive agent substantiated by inhibition of chemically induced cancer in rodents and prevention of cancer development and distant site metastasis in transgenic mouse models of cancer.	sulforaphane	18-21	RNA exonuclease 2	Mus musculus	0-16
20304643-0	2010	Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane.	sulforaphane	110-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	9-13
20304643-4	2010	Enhancement of GSH biosynthetic enzymes including the rate-limiting glutamate cysteine ligase (GCL), as well as other Phase II detoxification enzymes results from SFN-mediated induction of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response elements (ARE) signaling pathway.	sulforaphane	163-166	glutamate-cysteine ligase catalytic subunit	Homo sapiens	68-93
20304643-4	2010	Enhancement of GSH biosynthetic enzymes including the rate-limiting glutamate cysteine ligase (GCL), as well as other Phase II detoxification enzymes results from SFN-mediated induction of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response elements (ARE) signaling pathway.	sulforaphane	163-166	glutamate-cysteine ligase catalytic subunit	Homo sapiens	95-98
20304643-4	2010	Enhancement of GSH biosynthetic enzymes including the rate-limiting glutamate cysteine ligase (GCL), as well as other Phase II detoxification enzymes results from SFN-mediated induction of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response elements (ARE) signaling pathway.	sulforaphane	163-166	NFE2 like bZIP transcription factor 2	Homo sapiens	193-236
20304643-4	2010	Enhancement of GSH biosynthetic enzymes including the rate-limiting glutamate cysteine ligase (GCL), as well as other Phase II detoxification enzymes results from SFN-mediated induction of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response elements (ARE) signaling pathway.	sulforaphane	163-166	NFE2 like bZIP transcription factor 2	Homo sapiens	238-242
20304643-5	2010	While isothiocyanate compounds such as SFN are among the most potent Nrf2 inducers known, we hypothesized that substitution of sulfur with selenium in the isothiocyanate functional group of SFN would result in an isoselenocyanate compound (SFN-isoSe) with enhanced Nrf2 induction capability.	sulforaphane	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
20304643-5	2010	While isothiocyanate compounds such as SFN are among the most potent Nrf2 inducers known, we hypothesized that substitution of sulfur with selenium in the isothiocyanate functional group of SFN would result in an isoselenocyanate compound (SFN-isoSe) with enhanced Nrf2 induction capability.	sulforaphane	190-193	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
20304643-5	2010	While isothiocyanate compounds such as SFN are among the most potent Nrf2 inducers known, we hypothesized that substitution of sulfur with selenium in the isothiocyanate functional group of SFN would result in an isoselenocyanate compound (SFN-isoSe) with enhanced Nrf2 induction capability.	sulforaphane	190-193	NFE2 like bZIP transcription factor 2	Homo sapiens	265-269
20205397-4	2010	The SFN-induced formation of 4-HNE was suppressed in hGSTA1-1-overexpressing cells, which also acquired resistance to SFN-induced cytotoxicity, cell cycle arrest, and apoptosis.	sulforaphane	4-7	glutathione S-transferase alpha 1	Homo sapiens	53-59
20205397-4	2010	The SFN-induced formation of 4-HNE was suppressed in hGSTA1-1-overexpressing cells, which also acquired resistance to SFN-induced cytotoxicity, cell cycle arrest, and apoptosis.	sulforaphane	118-121	glutathione S-transferase alpha 1	Homo sapiens	53-59
20205397-5	2010	While resistance to SFN-induced cell cycle arrest by ectopic expression of hGSTA1-1 was associated with changes in levels of G2/M regulatory proteins, resistance to apoptosis correlated with an increased Bcl-xL/Bax ratio, inhibition of nuclear translocation of AIF, and attenuated cytochrome c release in cytosol.	sulforaphane	20-23	glutathione S-transferase alpha 1	Homo sapiens	75-83
20205397-5	2010	While resistance to SFN-induced cell cycle arrest by ectopic expression of hGSTA1-1 was associated with changes in levels of G2/M regulatory proteins, resistance to apoptosis correlated with an increased Bcl-xL/Bax ratio, inhibition of nuclear translocation of AIF, and attenuated cytochrome c release in cytosol.	sulforaphane	20-23	BCL2 like 1	Homo sapiens	204-210
20205397-5	2010	While resistance to SFN-induced cell cycle arrest by ectopic expression of hGSTA1-1 was associated with changes in levels of G2/M regulatory proteins, resistance to apoptosis correlated with an increased Bcl-xL/Bax ratio, inhibition of nuclear translocation of AIF, and attenuated cytochrome c release in cytosol.	sulforaphane	20-23	BCL2 associated X, apoptosis regulator	Homo sapiens	211-214
20205397-5	2010	While resistance to SFN-induced cell cycle arrest by ectopic expression of hGSTA1-1 was associated with changes in levels of G2/M regulatory proteins, resistance to apoptosis correlated with an increased Bcl-xL/Bax ratio, inhibition of nuclear translocation of AIF, and attenuated cytochrome c release in cytosol.	sulforaphane	20-23	cytochrome c, somatic	Homo sapiens	281-293
20233902-0	2010	Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.	sulforaphane	0-12	interleukin 6	Homo sapiens	39-52
20233902-0	2010	Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	75-125
20233902-1	2010	D,L-sulforaphane (SFN), a synthetic analogue of broccoli-derived L-isomer, inhibits viability of human prostate cancer cells and prevents development of prostate cancer and distant site metastasis in a transgenic mouse model.	sulforaphane	0-16	RNA exonuclease 2	Homo sapiens	18-21
19948220-2	2010	Sulforaphane is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	74-78
20166144-0	2010	Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	113-119
20166144-0	2010	Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	121-126
20204301-0	2010	p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.	sulforaphane	34-46	mitogen-activated protein kinase 14	Homo sapiens	0-3
20204301-0	2010	p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells.	sulforaphane	34-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	117-122
20204301-2	2010	In the present study, sulforaphane up-regulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells.	sulforaphane	22-34	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
20204301-2	2010	In the present study, sulforaphane up-regulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells.	sulforaphane	22-34	glutathione S-transferase alpha 1	Homo sapiens	119-126
20204301-2	2010	In the present study, sulforaphane up-regulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells.	sulforaphane	22-34	thioredoxin reductase 1	Homo sapiens	155-159
20204301-2	2010	In the present study, sulforaphane up-regulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells.	sulforaphane	22-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	181-197
20204301-2	2010	In the present study, sulforaphane up-regulated the expression of two Nrf2-dependent enzymes, glutathione transferase (GSTA1-1) and thioredoxin reductase (TR-1), and down-regulated cyclooxygenase 2 (COX-2) in human bladder cancer T24 cells.	sulforaphane	22-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	199-204
20204301-3	2010	This action of sulforaphane was associated with the p38 MAPK activity.	sulforaphane	15-27	mitogen-activated protein kinase 14	Homo sapiens	52-55
19948220-11	2010	Decreases on Mn-superoxide dismutase (SOD), catalase, and heme oxygenase-1 levels by I/R were increased by sulforaphane treatment and pretreatment of 5-HD blocked the sulforaphane effects.	sulforaphane	107-119	catalase	Rattus norvegicus	44-52
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	mitogen-activated protein kinase 14	Homo sapiens	16-19
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	glutathione S-transferase alpha 1	Homo sapiens	99-106
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	thioredoxin reductase 1	Homo sapiens	111-115
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-144
19948220-11	2010	Decreases on Mn-superoxide dismutase (SOD), catalase, and heme oxygenase-1 levels by I/R were increased by sulforaphane treatment and pretreatment of 5-HD blocked the sulforaphane effects.	sulforaphane	107-119	heme oxygenase 1	Rattus norvegicus	58-74
19948220-12	2010	Increases in Bax and caspase-3 levels, and decrease in Bcl-2 level by I/R were attenuated by sulforaphane treatment.	sulforaphane	93-105	BCL2 associated X, apoptosis regulator	Rattus norvegicus	13-16
19948220-12	2010	Increases in Bax and caspase-3 levels, and decrease in Bcl-2 level by I/R were attenuated by sulforaphane treatment.	sulforaphane	93-105	caspase 3	Rattus norvegicus	21-30
19948220-12	2010	Increases in Bax and caspase-3 levels, and decrease in Bcl-2 level by I/R were attenuated by sulforaphane treatment.	sulforaphane	93-105	BCL2, apoptosis regulator	Rattus norvegicus	55-60
20196847-8	2010	Cells treated with cytotoxic concentrations of SFN have reduced cell migration and increased apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP).	sulforaphane	47-50	BCL2 antagonist/killer 1	Homo sapiens	133-136
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	mitogen-activated protein kinase 14	Homo sapiens	191-194
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	thioredoxin reductase 1	Homo sapiens	271-275
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	61-73	prostaglandin-endoperoxide synthase 2	Homo sapiens	280-285
20204301-4	2010	When a specific p38 MAPK inhibitor, SB202190, was used, both sulforaphane-induced up-regulation of GSTA1-1 and TR-1 and down-regulation of COX-2 were eliminated; in contrast, an activator of p38 MAPK, anisomycin, enhanced the effect of sulforaphane on modulation of GST, TR-1 and COX-2 expression.	sulforaphane	236-248	mitogen-activated protein kinase 14	Homo sapiens	16-19
20204301-5	2010	Moreover, it was established that anisomycin increased nuclear translocation of Nrf2, whereas SB202190 abrogated sulforaphane-induced Nrf2 translocation into the nucleus.	sulforaphane	113-125	NFE2 like bZIP transcription factor 2	Homo sapiens	134-138
20204301-6	2010	In summary, these data suggest that p38 MAPK activation can regulate Nrf2-antioxidant response element (ARE)-driven enzymes and COX-2 expression, thereby facilitating the role of sulforaphane in cancer prevention.	sulforaphane	179-191	mitogen-activated protein kinase 14	Homo sapiens	36-39
20204301-6	2010	In summary, these data suggest that p38 MAPK activation can regulate Nrf2-antioxidant response element (ARE)-driven enzymes and COX-2 expression, thereby facilitating the role of sulforaphane in cancer prevention.	sulforaphane	179-191	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
20204301-6	2010	In summary, these data suggest that p38 MAPK activation can regulate Nrf2-antioxidant response element (ARE)-driven enzymes and COX-2 expression, thereby facilitating the role of sulforaphane in cancer prevention.	sulforaphane	179-191	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
20204301-7	2010	This study strongly supports the contention that p38 MAPK is a pivotal and efficient target of sulforaphane in the chemoprevention of bladder cancer.	sulforaphane	95-107	mitogen-activated protein kinase 14	Homo sapiens	49-52
20196847-8	2010	Cells treated with cytotoxic concentrations of SFN have reduced cell migration and increased apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP).	sulforaphane	47-50	poly(ADP-ribose) polymerase 1	Homo sapiens	165-210
20196847-8	2010	Cells treated with cytotoxic concentrations of SFN have reduced cell migration and increased apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP).	sulforaphane	47-50	poly(ADP-ribose) polymerase 1	Homo sapiens	212-216
20196847-10	2010	SFN treatment resulted in G1 cell cycle arrest through down modulation of RB phosphorylation and by protecting the RB-E2F-1 complex.	sulforaphane	0-3	RB transcriptional corepressor 1	Homo sapiens	74-76
20196847-8	2010	Cells treated with cytotoxic concentrations of SFN have reduced cell migration and increased apoptotic cell death via an increase in Bak/Bcl-2 ratio and cleavage of procaspase-9 and poly (ADP-ribose)-polymerase (PARP).	sulforaphane	47-50	BCL2 apoptosis regulator	Homo sapiens	137-142
19857366-7	2010	The expressions of proteins of the thioredoxin (Trx) superfamily including Trx1 and its precursor sulphoraphane, Trx2 and Trx reductase, were enhanced only in the steamed broccoli group.	sulforaphane	98-111	thioredoxin 1	Rattus norvegicus	35-46
19857366-7	2010	The expressions of proteins of the thioredoxin (Trx) superfamily including Trx1 and its precursor sulphoraphane, Trx2 and Trx reductase, were enhanced only in the steamed broccoli group.	sulforaphane	98-111	thioredoxin 1	Rattus norvegicus	48-51
19913604-3	2010	SFN is able to induce cytoprotective enzymes through the transcription factor Nrf2.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	78-82
19913604-6	2010	Immunofluorescent staining confirmed the nuclear translocation of Nrf2 after treatment with SFN.	sulforaphane	92-95	NFE2 like bZIP transcription factor 2	Rattus norvegicus	66-70
19913604-12	2010	SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase).	sulforaphane	0-3	catalase	Rattus norvegicus	205-213
19913604-12	2010	SFN attenuated CDDP-induced renal dysfunction, structural damage, oxidative/nitrosative stress, glutathione depletion, enhanced urinary hydrogen peroxide excretion and the decrease in antioxidant enzymes (catalase, glutathione peroxidase and glutathione-S-transferase).	sulforaphane	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	242-267
19558496-0	2010	Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	105-109
19830499-10	2010	Treatment of cells with a specific autophagy inhibitor (3-methyladenine) potentiated the proapoptotic effect of SUL, which was dependent on the activation of caspases and the release of cytochrome c to the cytosol.	sulforaphane	112-115	cytochrome c, somatic	Homo sapiens	186-198
20085276-12	2010	We hypothesize that within whole broccoli additional components enhanced sulforaphane-dependent upregulation of NQO1 in liver.	sulforaphane	73-85	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	112-116
19558496-5	2010	SFN but not ABG and its precursors I3C and ascorbic acid induced Nrf2 dependent gene expression at a relatively low concentration (5 micromol/l).	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
19558496-6	2010	Induction of Nrf2 due to SFN was accompanied by an increase in mRNA and protein levels of NADPH quinone oxidoreductase 1, heme oxygenase 1 and gamma-glutamylcysteine-synthetase.	sulforaphane	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
19558496-6	2010	Induction of Nrf2 due to SFN was accompanied by an increase in mRNA and protein levels of NADPH quinone oxidoreductase 1, heme oxygenase 1 and gamma-glutamylcysteine-synthetase.	sulforaphane	25-28	NAD(P)H quinone dehydrogenase 1	Homo sapiens	90-120
19558496-6	2010	Induction of Nrf2 due to SFN was accompanied by an increase in mRNA and protein levels of NADPH quinone oxidoreductase 1, heme oxygenase 1 and gamma-glutamylcysteine-synthetase.	sulforaphane	25-28	heme oxygenase 1	Homo sapiens	122-138
19558496-6	2010	Induction of Nrf2 due to SFN was accompanied by an increase in mRNA and protein levels of NADPH quinone oxidoreductase 1, heme oxygenase 1 and gamma-glutamylcysteine-synthetase.	sulforaphane	25-28	glutamate-cysteine ligase catalytic subunit	Homo sapiens	143-176
19715681-5	2010	Real-time reverse transcription-PCR assays revealed that CES1A1 mRNA was significantly induced by tert-butylhydroquinone (tBHQ) and sulforaphane (SFN), which are representative activators of Nrf2 in HepG2, Caco-2 and HeLa cells.	sulforaphane	132-144	NFE2 like bZIP transcription factor 2	Homo sapiens	191-195
19715681-5	2010	Real-time reverse transcription-PCR assays revealed that CES1A1 mRNA was significantly induced by tert-butylhydroquinone (tBHQ) and sulforaphane (SFN), which are representative activators of Nrf2 in HepG2, Caco-2 and HeLa cells.	sulforaphane	146-149	NFE2 like bZIP transcription factor 2	Homo sapiens	191-195
19949083-0	2010	Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner.	sulforaphane	0-12	toll like receptor 4	Homo sapiens	43-47
20208349-0	2010	Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells.	sulforaphane	0-12	tyrosinase	Mus musculus	55-65
20208349-3	2010	In this study, we found that sulforaphane inhibited melanogenesis and tyrosinase expression.	sulforaphane	29-41	tyrosinase	Mus musculus	70-80
20208349-5	2010	In addition, sulforaphane induced phosphorylated extracellular signal-regulated kinase (ERK) and inhibited phosphorylated p38.	sulforaphane	13-25	mitogen-activated protein kinase 1	Mus musculus	49-86
20208349-5	2010	In addition, sulforaphane induced phosphorylated extracellular signal-regulated kinase (ERK) and inhibited phosphorylated p38.	sulforaphane	13-25	mitogen-activated protein kinase 1	Mus musculus	88-91
20208349-5	2010	In addition, sulforaphane induced phosphorylated extracellular signal-regulated kinase (ERK) and inhibited phosphorylated p38.	sulforaphane	13-25	mitogen-activated protein kinase 14	Mus musculus	122-125
20208349-7	2010	Our data indicate that sulforaphane inhibited melanogenesis and tyrosinase expression by affecting the phosphorylated MAP kinase family.	sulforaphane	23-35	tyrosinase	Mus musculus	64-74
20039434-10	2010	The production of IL-17, TNFalpha, IL-6, and interferon-gamma by lymph node cells and spleen cells from these mice was markedly reduced by treatment with SFN.	sulforaphane	154-157	interleukin 17A	Mus musculus	18-23
20039434-10	2010	The production of IL-17, TNFalpha, IL-6, and interferon-gamma by lymph node cells and spleen cells from these mice was markedly reduced by treatment with SFN.	sulforaphane	154-157	tumor necrosis factor	Mus musculus	25-33
20039434-10	2010	The production of IL-17, TNFalpha, IL-6, and interferon-gamma by lymph node cells and spleen cells from these mice was markedly reduced by treatment with SFN.	sulforaphane	154-157	interleukin 6	Mus musculus	35-39
20039434-10	2010	The production of IL-17, TNFalpha, IL-6, and interferon-gamma by lymph node cells and spleen cells from these mice was markedly reduced by treatment with SFN.	sulforaphane	154-157	interferon gamma	Mus musculus	45-61
20104266-0	2010	Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest.	sulforaphane	0-12	cyclin dependent kinase inhibitor 3	Homo sapiens	23-56
20104266-0	2010	Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest.	sulforaphane	0-12	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	58-61
20104266-3	2010	Cell cycle arrest induced by SFN was associated with a significant increase in the p21 protein level and a decrease in cyclin B expression, but there was no change in the cyclin A protein level.	sulforaphane	29-32	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-86
20104266-5	2010	Furthermore, SFN induced p21 protein expression in a nude mouse xenograft model suggesting that SFN is a potent inducer of the p21 protein in human oral squamous carcinoma cells.	sulforaphane	13-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	25-28
20104266-5	2010	Furthermore, SFN induced p21 protein expression in a nude mouse xenograft model suggesting that SFN is a potent inducer of the p21 protein in human oral squamous carcinoma cells.	sulforaphane	13-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	127-130
20104266-5	2010	Furthermore, SFN induced p21 protein expression in a nude mouse xenograft model suggesting that SFN is a potent inducer of the p21 protein in human oral squamous carcinoma cells.	sulforaphane	96-99	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	25-28
20104266-5	2010	Furthermore, SFN induced p21 protein expression in a nude mouse xenograft model suggesting that SFN is a potent inducer of the p21 protein in human oral squamous carcinoma cells.	sulforaphane	96-99	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	127-130
19685289-5	2010	Our study shows that combination treatment with resveratrol and sulforaphane inhibits cell proliferation and migration, reduces cell viability, induces lactate dehydrogenase release, decreases pro-survival Akt phosphorylation and increases caspase-3 activation.	sulforaphane	64-76	caspase 3	Homo sapiens	240-249
19934254-9	2010	Significantly, treatment of cells with hydrogen peroxide (H(2)O(2)) and phyto-oxidant sulforaphane further stimulated IRES(Nrf2)-mediated translation initiation despite the attenuation of global protein synthesis.	sulforaphane	86-98	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
19949083-8	2010	SFN formed adducts with cysteine residues in the extracellular domain of TLR4 as confirmed by liquid chromatography-tandem mass spectrometry analysis and the inhibitory effects of SFN on oligomerization and NF-kappaB activation were reversed by thiol donors (DTT and N-acetyl-L-cysteine).	sulforaphane	0-3	toll like receptor 4	Homo sapiens	73-77
20175231-0	2010	[Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells].	sulforaphane	20-32	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
20175231-1	2010	OBJECTIVE: To investigate the effect of tBHQ and sulforaphane on the protein expression in Nrf2-ARE signaling pathway of Caco2 cells.	sulforaphane	49-61	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
19949083-8	2010	SFN formed adducts with cysteine residues in the extracellular domain of TLR4 as confirmed by liquid chromatography-tandem mass spectrometry analysis and the inhibitory effects of SFN on oligomerization and NF-kappaB activation were reversed by thiol donors (DTT and N-acetyl-L-cysteine).	sulforaphane	180-183	toll like receptor 4	Homo sapiens	73-77
19729611-5	2009	Treatment with sulforaphane, a dietary antioxidant, activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC activation via Nrf2.	sulforaphane	15-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	62-66
20175231-4	2010	RESULTS: Nrf2, AKR1C1 and NQO1 protein expressions were increased time-dependently in Caco2 cells after treatment with tBHQ and SFN.	sulforaphane	128-131	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
20175231-4	2010	RESULTS: Nrf2, AKR1C1 and NQO1 protein expressions were increased time-dependently in Caco2 cells after treatment with tBHQ and SFN.	sulforaphane	128-131	aldo-keto reductase family 1 member C1	Homo sapiens	15-21
20175231-4	2010	RESULTS: Nrf2, AKR1C1 and NQO1 protein expressions were increased time-dependently in Caco2 cells after treatment with tBHQ and SFN.	sulforaphane	128-131	NAD(P)H quinone dehydrogenase 1	Homo sapiens	26-30
20175231-5	2010	Time-course experiments showed that tBHQ and SFN increased the accumulation of Nrf2, and concomitantly increased the protein levels of AKR1C1 and NQO1.	sulforaphane	45-48	NFE2 like bZIP transcription factor 2	Homo sapiens	79-83
20175231-5	2010	Time-course experiments showed that tBHQ and SFN increased the accumulation of Nrf2, and concomitantly increased the protein levels of AKR1C1 and NQO1.	sulforaphane	45-48	aldo-keto reductase family 1 member C1	Homo sapiens	135-141
20175231-5	2010	Time-course experiments showed that tBHQ and SFN increased the accumulation of Nrf2, and concomitantly increased the protein levels of AKR1C1 and NQO1.	sulforaphane	45-48	NAD(P)H quinone dehydrogenase 1	Homo sapiens	146-150
20175231-8	2010	CONCLUSION: tBHQ and SFN induced nuclear accumulation of Nrf2 and activated Nrf2-dependent regulation of ARE-mediated gene expression in Caco2 cells.	sulforaphane	21-24	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
20175231-8	2010	CONCLUSION: tBHQ and SFN induced nuclear accumulation of Nrf2 and activated Nrf2-dependent regulation of ARE-mediated gene expression in Caco2 cells.	sulforaphane	21-24	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
19780897-3	2009	In this study, we demonstrated that treatment of the dopaminergic-like neuroblastoma SH-SY5Y cell line with sulforaphane (SF), a cruciferous vegetables inducer, resulted in significant increases of total GSH level, NAD(P)H : quinone oxidoreductase-1, GSH-transferase and -reductase, but not GSH-peroxidase, catalase and superoxide dismutase activities.	sulforaphane	108-120	NAD(P)H quinone dehydrogenase 1	Homo sapiens	215-281
19780897-3	2009	In this study, we demonstrated that treatment of the dopaminergic-like neuroblastoma SH-SY5Y cell line with sulforaphane (SF), a cruciferous vegetables inducer, resulted in significant increases of total GSH level, NAD(P)H : quinone oxidoreductase-1, GSH-transferase and -reductase, but not GSH-peroxidase, catalase and superoxide dismutase activities.	sulforaphane	108-120	catalase	Homo sapiens	307-315
19780897-3	2009	In this study, we demonstrated that treatment of the dopaminergic-like neuroblastoma SH-SY5Y cell line with sulforaphane (SF), a cruciferous vegetables inducer, resulted in significant increases of total GSH level, NAD(P)H : quinone oxidoreductase-1, GSH-transferase and -reductase, but not GSH-peroxidase, catalase and superoxide dismutase activities.	sulforaphane	122-124	NAD(P)H quinone dehydrogenase 1	Homo sapiens	215-281
19780897-3	2009	In this study, we demonstrated that treatment of the dopaminergic-like neuroblastoma SH-SY5Y cell line with sulforaphane (SF), a cruciferous vegetables inducer, resulted in significant increases of total GSH level, NAD(P)H : quinone oxidoreductase-1, GSH-transferase and -reductase, but not GSH-peroxidase, catalase and superoxide dismutase activities.	sulforaphane	122-124	catalase	Homo sapiens	307-315
19885601-4	2009	Inhibition of MEK/ERK and PI3K/AKT pathways synergistically inhibited cell migration and capillary tube formation by HUVECs and further enhanced the anti-angiogenic effects of sulforaphane.	sulforaphane	176-188	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
19885601-4	2009	Inhibition of MEK/ERK and PI3K/AKT pathways synergistically inhibited cell migration and capillary tube formation by HUVECs and further enhanced the anti-angiogenic effects of sulforaphane.	sulforaphane	176-188	mitogen-activated protein kinase 1	Homo sapiens	18-21
19885601-4	2009	Inhibition of MEK/ERK and PI3K/AKT pathways synergistically inhibited cell migration and capillary tube formation by HUVECs and further enhanced the anti-angiogenic effects of sulforaphane.	sulforaphane	176-188	AKT serine/threonine kinase 1	Homo sapiens	31-34
19885601-6	2009	Inhibition of the MEK/ERK and PI3K/AKT pathways synergistically induced FOXO transcriptional activity and inhibited cell migration and capillary tube formation; these events were further enhanced in the presence of sulforaphane.	sulforaphane	215-227	mitogen-activated protein kinase kinase 7	Homo sapiens	18-21
19885601-6	2009	Inhibition of the MEK/ERK and PI3K/AKT pathways synergistically induced FOXO transcriptional activity and inhibited cell migration and capillary tube formation; these events were further enhanced in the presence of sulforaphane.	sulforaphane	215-227	mitogen-activated protein kinase 1	Homo sapiens	22-25
19885601-6	2009	Inhibition of the MEK/ERK and PI3K/AKT pathways synergistically induced FOXO transcriptional activity and inhibited cell migration and capillary tube formation; these events were further enhanced in the presence of sulforaphane.	sulforaphane	215-227	AKT serine/threonine kinase 1	Homo sapiens	35-38
19812222-0	2009	Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention.	sulforaphane	8-20	histone deacetylase 9	Homo sapiens	24-43
19812222-5	2009	We have previously found that sulforaphane (SFN), a compound found in cruciferous vegetables, inhibits HDAC activity in human colorectal and prostate cancer cells.	sulforaphane	30-42	histone deacetylase 9	Homo sapiens	103-107
19812222-5	2009	We have previously found that sulforaphane (SFN), a compound found in cruciferous vegetables, inhibits HDAC activity in human colorectal and prostate cancer cells.	sulforaphane	44-47	histone deacetylase 9	Homo sapiens	103-107
19812222-6	2009	Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, we previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention.	sulforaphane	126-138	histone deacetylase 9	Homo sapiens	77-81
19812222-6	2009	Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, we previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention.	sulforaphane	126-138	histone deacetylase 9	Homo sapiens	151-155
19812222-6	2009	Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, we previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention.	sulforaphane	126-138	H3 histone pseudogene 16	Homo sapiens	237-240
19812222-6	2009	Based on the similarity of SFN metabolites and other phytochemicals to known HDAC inhibitors, we previously demonstrated that sulforaphane acted as an HDAC inhibitor in the prostate, causing enhanced histone acetylation, derepression of P21 and Bax, and induction of cell cycle arrest/apoptosis, leading to cancer prevention.	sulforaphane	126-138	BCL2 associated X, apoptosis regulator	Homo sapiens	245-248
19729611-5	2009	Treatment with sulforaphane, a dietary antioxidant, activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC activation via Nrf2.	sulforaphane	15-27	mitogen-activated protein kinase 14	Mus musculus	82-85
19729611-5	2009	Treatment with sulforaphane, a dietary antioxidant, activated Nrf2 and suppressed p38-VCAM-1 signaling at the susceptible site in wild-type but not Nrf2(-/-) animals, indicating that it suppresses EC activation via Nrf2.	sulforaphane	15-27	vascular cell adhesion molecule 1	Mus musculus	86-92
19595745-5	2009	When co-incubated, optimal concentrations of Se (40 nM) and sulforaphane (4 microM) only modestly increased TrxR2 protein (approximately 1.3-fold), compared with TrxR1 (approximately 4-fold).	sulforaphane	60-72	thioredoxin reductase 2	Homo sapiens	108-113
19595745-9	2009	In Se deficiency an inactive (possibly truncated) TrxR1 is produced in response to stimulus by sulforaphane and A23187.	sulforaphane	95-107	thioredoxin reductase 1	Homo sapiens	50-55
19363674-2	2009	In the present study, we examined the actions of PEITC and sulphoraphane in modulating the activity of protein kinase C (PKC) and telomerase in cervical cancer cell line HeLa.	sulforaphane	59-72	protein kinase C alpha	Homo sapiens	121-124
19805354-0	2009	Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.	sulforaphane	0-12	androgen receptor	Homo sapiens	30-47
19805354-0	2009	Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.	sulforaphane	0-12	histone deacetylase 6	Homo sapiens	89-110
19805354-6	2009	However, it is not known whether the effects of sulforaphane involve suppression of AR.	sulforaphane	48-60	androgen receptor	Homo sapiens	84-86
19805354-7	2009	We hypothesized that sulforaphane treatment would lead to hyperacetylation of HSP90 and that this would destabilize AR and attenuate AR signaling.	sulforaphane	21-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
19805354-7	2009	We hypothesized that sulforaphane treatment would lead to hyperacetylation of HSP90 and that this would destabilize AR and attenuate AR signaling.	sulforaphane	21-33	androgen receptor	Homo sapiens	116-118
19805354-7	2009	We hypothesized that sulforaphane treatment would lead to hyperacetylation of HSP90 and that this would destabilize AR and attenuate AR signaling.	sulforaphane	21-33	androgen receptor	Homo sapiens	133-135
19805354-8	2009	We confirmed this by demonstrating that sulforaphane enhances HSP90 acetylation, thereby inhibiting its association with AR.	sulforaphane	40-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	62-67
19805354-8	2009	We confirmed this by demonstrating that sulforaphane enhances HSP90 acetylation, thereby inhibiting its association with AR.	sulforaphane	40-52	androgen receptor	Homo sapiens	121-123
19805354-10	2009	Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA.	sulforaphane	9-21	histone deacetylase 6	Homo sapiens	31-36
19805354-10	2009	Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA.	sulforaphane	9-21	histone deacetylase 6	Homo sapiens	140-145
19805354-10	2009	Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA.	sulforaphane	9-21	histone deacetylase 6	Homo sapiens	140-145
19805354-10	2009	Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA.	sulforaphane	78-90	androgen receptor	Homo sapiens	94-96
19805354-10	2009	Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA.	sulforaphane	78-90	histone deacetylase 6	Homo sapiens	140-145
19805354-10	2009	Finally, sulforaphane inhibits HDAC6 deacetylase activity, and the effects of sulforaphane on AR protein are abrogated by overexpression of HDAC6 and mimicked by HDAC6 siRNA.	sulforaphane	78-90	histone deacetylase 6	Homo sapiens	140-145
19805354-11	2009	The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent"s effects in prostate cancer.	sulforaphane	20-32	histone deacetylase 6	Homo sapiens	36-41
19805354-11	2009	The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent"s effects in prostate cancer.	sulforaphane	20-32	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
19805354-11	2009	The inactivation by sulforaphane of HDAC6-mediated HSP90 deacetylation and consequent attenuation of AR signaling represents a newly defined mechanism that may help explain this agent"s effects in prostate cancer.	sulforaphane	20-32	androgen receptor	Homo sapiens	101-103
19671797-0	2009	Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.	sulforaphane	37-49	FBJ osteosarcoma oncogene	Mus musculus	92-96
19671797-2	2009	Although the role of sulforaphane in the induction of the transcription factor Nrf2 has been studied extensively, there is also evidence that inhibition of the transcription factor activator protein-1 (AP-1) may contribute to the chemopreventive properties of this compound.	sulforaphane	21-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
19671797-0	2009	Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer.	sulforaphane	37-49	jun proto-oncogene	Mus musculus	14-33
19671797-4	2009	We also show that sulforaphane pretreatment is able to reduce the activity of AP-1 luciferase in the skin of transgenic mice after UVB.	sulforaphane	18-30	jun proto-oncogene	Mus musculus	78-82
19671797-5	2009	Chromatin immunoprecipitation analysis verified that a main constituent of the AP-1 dimer, cFos, is inhibited from binding to the AP-1 DNA binding site by sulforaphane.	sulforaphane	155-167	jun proto-oncogene	Mus musculus	79-83
19671797-5	2009	Chromatin immunoprecipitation analysis verified that a main constituent of the AP-1 dimer, cFos, is inhibited from binding to the AP-1 DNA binding site by sulforaphane.	sulforaphane	155-167	FBJ osteosarcoma oncogene	Mus musculus	91-95
19671797-5	2009	Chromatin immunoprecipitation analysis verified that a main constituent of the AP-1 dimer, cFos, is inhibited from binding to the AP-1 DNA binding site by sulforaphane.	sulforaphane	155-167	jun proto-oncogene	Mus musculus	130-134
19671797-6	2009	Electrophoretic mobility shift assay analysis of nuclear proteins also shows that sulforaphane and diamide, both known to react with cysteine amino acids, are effective at inhibiting AP-1 from binding to its response element.	sulforaphane	82-94	jun proto-oncogene	Mus musculus	183-187
19671797-7	2009	Using truncated recombinant cFos and cJun, we show that mutation of critical cysteines in the DNA-binding domain of these proteins (Cys(154) in cFos and Cys(272) in cJun) results in loss of sensitivity to both sulforaphane and diamide in electrophoretic mobility shift assay analysis.	sulforaphane	210-222	FBJ osteosarcoma oncogene	Mus musculus	28-32
19671797-7	2009	Using truncated recombinant cFos and cJun, we show that mutation of critical cysteines in the DNA-binding domain of these proteins (Cys(154) in cFos and Cys(272) in cJun) results in loss of sensitivity to both sulforaphane and diamide in electrophoretic mobility shift assay analysis.	sulforaphane	210-222	jun proto-oncogene	Mus musculus	37-41
19671797-7	2009	Using truncated recombinant cFos and cJun, we show that mutation of critical cysteines in the DNA-binding domain of these proteins (Cys(154) in cFos and Cys(272) in cJun) results in loss of sensitivity to both sulforaphane and diamide in electrophoretic mobility shift assay analysis.	sulforaphane	210-222	FBJ osteosarcoma oncogene	Mus musculus	144-148
19671797-7	2009	Using truncated recombinant cFos and cJun, we show that mutation of critical cysteines in the DNA-binding domain of these proteins (Cys(154) in cFos and Cys(272) in cJun) results in loss of sensitivity to both sulforaphane and diamide in electrophoretic mobility shift assay analysis.	sulforaphane	210-222	jun proto-oncogene	Mus musculus	165-169
19671797-8	2009	Together, these data indicate that inhibition of AP-1 activity may be an important molecular mechanism in chemoprevention of squamous cell carcinoma by sulforaphane.	sulforaphane	152-164	jun proto-oncogene	Mus musculus	49-53
19515491-3	2009	These beneficial effects of sulforaphane have been shown to involve induction of a group of cytoprotective, Nrf2-driven genes, whose protein products include free radical scavenging and detoxifying enzymes.	sulforaphane	28-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	108-112
19429419-5	2009	Sulforaphane significantly suppressed the expression of MDR1 and CYP3A mRNAs induced by atorvastatin lactone, lovastatin acid, and lovastatin lactone, comparable to the control level, and moderately inhibited that by cerivastatin acid, fluvastatin acid and simvastatin lactone.	sulforaphane	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	56-60
19653226-0	2009	Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells.	sulforaphane	21-33	heme oxygenase 1	Homo sapiens	75-91
19653226-1	2009	Sulforaphane is known to be an indirect antioxidant that acts by inducing NF-E2-related factor 2 (Nrf2)-dependent phase II enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	74-96
19653226-1	2009	Sulforaphane is known to be an indirect antioxidant that acts by inducing NF-E2-related factor 2 (Nrf2)-dependent phase II enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
19653226-2	2009	In the present study, we investigated the effect of sulforaphane on the expression of heme oxygenase-1 (HO-1) in human intestinal Int 407 cells.	sulforaphane	52-64	heme oxygenase 1	Homo sapiens	86-102
19653226-2	2009	In the present study, we investigated the effect of sulforaphane on the expression of heme oxygenase-1 (HO-1) in human intestinal Int 407 cells.	sulforaphane	52-64	heme oxygenase 1	Homo sapiens	104-108
19653226-3	2009	RT-PCR and Western blot data revealed that sulforaphane induced an increase in HO-1 expression at the mRNA and protein levels, respectively.	sulforaphane	43-55	heme oxygenase 1	Homo sapiens	79-83
19653226-5	2009	Actinomycin D (an RNA synthesis inhibitor) and cycloheximide (a protein synthesis inhibitor) inhibited sulforaphane-responsive HO-1 mRNA expression, indicating that sulforaphane is a requirement for transcription and de novo protein synthesis.	sulforaphane	103-115	heme oxygenase 1	Homo sapiens	127-131
19653226-5	2009	Actinomycin D (an RNA synthesis inhibitor) and cycloheximide (a protein synthesis inhibitor) inhibited sulforaphane-responsive HO-1 mRNA expression, indicating that sulforaphane is a requirement for transcription and de novo protein synthesis.	sulforaphane	165-177	heme oxygenase 1	Homo sapiens	127-131
19653226-6	2009	Moreover, sulforaphane increased the nuclear levels of Nrf2 and increased the binding activity of nuclear proteins to the antioxidant responsive element consensus sequence.	sulforaphane	10-22	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
19653226-7	2009	We also found that U0126, an ERK kinase inhibitor, suppressed the sulforaphane-induced HO-1 expression and nuclear translocation of Nrf2.	sulforaphane	66-78	mitogen-activated protein kinase 1	Homo sapiens	29-32
19653226-7	2009	We also found that U0126, an ERK kinase inhibitor, suppressed the sulforaphane-induced HO-1 expression and nuclear translocation of Nrf2.	sulforaphane	66-78	heme oxygenase 1	Homo sapiens	87-91
19653226-7	2009	We also found that U0126, an ERK kinase inhibitor, suppressed the sulforaphane-induced HO-1 expression and nuclear translocation of Nrf2.	sulforaphane	66-78	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	39-51	mitogen-activated protein kinase 1	Homo sapiens	115-118
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	39-51	heme oxygenase 1	Homo sapiens	123-127
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	39-51	mitogen-activated protein kinase 1	Homo sapiens	240-243
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	39-51	heme oxygenase 1	Homo sapiens	248-252
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	167-179	mitogen-activated protein kinase 1	Homo sapiens	115-118
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	167-179	heme oxygenase 1	Homo sapiens	123-127
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	167-179	mitogen-activated protein kinase 1	Homo sapiens	240-243
19653226-8	2009	Moreover, the cytoprotective effect of sulforaphane on indomethancin-induced cytotoxicity was partially blocked by ERK and HO-1 inhibitors, further demonstrating that sulforaphane attenuated oxidative stress through a pathway that involved ERK and HO-1.	sulforaphane	167-179	heme oxygenase 1	Homo sapiens	248-252
19277846-0	2009	Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.	sulforaphane	0-12	tumor necrosis factor	Mus musculus	22-31
19277846-0	2009	Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.	sulforaphane	0-12	mitogen-activated protein kinase 14	Mus musculus	54-57
19277846-0	2009	Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.	sulforaphane	0-12	vascular cell adhesion molecule 1	Mus musculus	73-79
19277846-0	2009	Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.	sulforaphane	0-12	mast cell protease 1	Mus musculus	84-89
19277846-3	2009	RESULTS: One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM-1 mRNA and protein levels, but had no effect on TNF-alpha-induced ICAM-1 expression.	sulforaphane	62-74	tumor necrosis factor	Mus musculus	96-105
19277846-3	2009	RESULTS: One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM-1 mRNA and protein levels, but had no effect on TNF-alpha-induced ICAM-1 expression.	sulforaphane	62-74	mast cell protease 1	Mus musculus	114-119
19277846-3	2009	RESULTS: One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM-1 mRNA and protein levels, but had no effect on TNF-alpha-induced ICAM-1 expression.	sulforaphane	62-74	vascular cell adhesion molecule 1	Mus musculus	124-130
19277846-3	2009	RESULTS: One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM-1 mRNA and protein levels, but had no effect on TNF-alpha-induced ICAM-1 expression.	sulforaphane	62-74	tumor necrosis factor	Mus musculus	177-186
19277846-3	2009	RESULTS: One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed TNF-alpha-induced MCP-1 and VCAM-1 mRNA and protein levels, but had no effect on TNF-alpha-induced ICAM-1 expression.	sulforaphane	62-74	intercellular adhesion molecule 1	Mus musculus	195-201
19277846-4	2009	Sulforaphane also inhibited TNF-alpha-induced activation of p38 MAP kinase, but not c-Jun-N-terminal kinase.	sulforaphane	0-12	tumor necrosis factor	Mus musculus	28-37
19277846-4	2009	Sulforaphane also inhibited TNF-alpha-induced activation of p38 MAP kinase, but not c-Jun-N-terminal kinase.	sulforaphane	0-12	mitogen-activated protein kinase 14	Mus musculus	60-63
19277846-6	2009	Expression of dominant negative Nrf2 inhibited sulforaphane-induced antioxidant response element (ARE)-driven promoter activity, but had no effect on sulforaphane-mediated inhibition of VCAM-1 and MCP-1 expression.	sulforaphane	47-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
19362136-4	2009	In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7.	sulforaphane	58-70	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	140-146
19362136-4	2009	In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7.	sulforaphane	58-70	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	151-157
18829980-10	2009	Freshly isolated patient tumour cells expressing markers for TICs could be sensitised by sulforaphane for TRAIL-induced cytotoxicity.	sulforaphane	89-101	TNF superfamily member 10	Homo sapiens	106-111
19125416-7	2009	Treatment of organotypic nigrostriatal cocultures with either tert-butylhydroquinone (tBHQ) or sulforaphane, known activators of Nrf2, mitigated dopaminergic cell loss.	sulforaphane	95-107	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133
19712481-4	2009	We examined whether the inhibitory activities of bioactive compounds from cruciferous vegetables, such as Benzyl isothiocyanate (BITC) and sulforaphane, extended to STAT3 activation in PANC-1 human pancreatic cancer cells.	sulforaphane	139-151	signal transducer and activator of transcription 3	Homo sapiens	165-170
19712481-6	2009	Sulforaphane had minimal effect on the direct inhibition of STAT3 tyrosine phosphorylation, however, suggesting its inhibitory activities are most likely STAT3-independent.	sulforaphane	0-12	signal transducer and activator of transcription 3	Homo sapiens	154-159
19712481-10	2009	Furthermore, combinations of BITC and sulforaphane inhibited cell viability and STAT3 phosphorylation more dramatically than either agent alone.	sulforaphane	38-50	signal transducer and activator of transcription 3	Homo sapiens	80-85
18805045-0	2009	Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-88
18805045-5	2009	Also, we observed that SFN inhibited COX-2 but not COX-1.	sulforaphane	23-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	37-42
18805045-8	2009	These results show that SFN can act as a potent anti-oral cancer compound by inhibiting COX-2 activity.	sulforaphane	24-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93
19491303-2	2009	In this study, we examined the influence of sulphoraphane (SPN), one of the most potent inducers of the phase II enzymes on the production of MMPs by pro-inflammatory cytokines in human articular chondrocytes.	sulforaphane	44-57	matrix metallopeptidase 1	Homo sapiens	142-146
19491303-2	2009	In this study, we examined the influence of sulphoraphane (SPN), one of the most potent inducers of the phase II enzymes on the production of MMPs by pro-inflammatory cytokines in human articular chondrocytes.	sulforaphane	59-62	matrix metallopeptidase 1	Homo sapiens	142-146
19491303-4	2009	Induction of a phase II enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), in chondrocytes was assayed after incubation with various concentrations of SPN.	sulforaphane	149-152	NAD(P)H quinone dehydrogenase 1	Homo sapiens	32-64
19491303-4	2009	Induction of a phase II enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), in chondrocytes was assayed after incubation with various concentrations of SPN.	sulforaphane	149-152	NAD(P)H quinone dehydrogenase 1	Homo sapiens	66-70
19491303-8	2009	RESULTS: SPN significantly induced NQO1 activity in chondrocytes and the induction was maximal at 24 h. SPN inhibited the production of MMP-1, -3 and -13 protein and mRNA induced by either IL-1 or TNF-alpha in a dose-dependent manner.	sulforaphane	9-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	35-39
19491303-8	2009	RESULTS: SPN significantly induced NQO1 activity in chondrocytes and the induction was maximal at 24 h. SPN inhibited the production of MMP-1, -3 and -13 protein and mRNA induced by either IL-1 or TNF-alpha in a dose-dependent manner.	sulforaphane	9-12	matrix metallopeptidase 1	Homo sapiens	136-153
19491303-8	2009	RESULTS: SPN significantly induced NQO1 activity in chondrocytes and the induction was maximal at 24 h. SPN inhibited the production of MMP-1, -3 and -13 protein and mRNA induced by either IL-1 or TNF-alpha in a dose-dependent manner.	sulforaphane	9-12	tumor necrosis factor	Homo sapiens	197-206
19303893-0	2009	Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.	sulforaphane	59-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
19303893-1	2009	Sulforaphane can stimulate cellular adaptation to redox stressors through transcription factor Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
19303893-3	2009	Furthermore, the rate of glutathione synthesis following its acute depletion upon treatment with 3 micromol/l sulforaphane was very substantially lower in Nrf2(-/-) MEFs than in wild-type cells, and the rebound leading to a approximately 1.9-fold increase in glutathione that occurred 12-24 h after Nrf2(+/+) MEFs were treated with sulforaphane was not observed in Nrf2(-/-) fibroblasts.	sulforaphane	110-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
19303893-3	2009	Furthermore, the rate of glutathione synthesis following its acute depletion upon treatment with 3 micromol/l sulforaphane was very substantially lower in Nrf2(-/-) MEFs than in wild-type cells, and the rebound leading to a approximately 1.9-fold increase in glutathione that occurred 12-24 h after Nrf2(+/+) MEFs were treated with sulforaphane was not observed in Nrf2(-/-) fibroblasts.	sulforaphane	110-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	299-303
19303893-3	2009	Furthermore, the rate of glutathione synthesis following its acute depletion upon treatment with 3 micromol/l sulforaphane was very substantially lower in Nrf2(-/-) MEFs than in wild-type cells, and the rebound leading to a approximately 1.9-fold increase in glutathione that occurred 12-24 h after Nrf2(+/+) MEFs were treated with sulforaphane was not observed in Nrf2(-/-) fibroblasts.	sulforaphane	110-122	nuclear factor, erythroid derived 2, like 2	Mus musculus	299-303
19303893-3	2009	Furthermore, the rate of glutathione synthesis following its acute depletion upon treatment with 3 micromol/l sulforaphane was very substantially lower in Nrf2(-/-) MEFs than in wild-type cells, and the rebound leading to a approximately 1.9-fold increase in glutathione that occurred 12-24 h after Nrf2(+/+) MEFs were treated with sulforaphane was not observed in Nrf2(-/-) fibroblasts.	sulforaphane	332-344	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
19303893-5	2009	Pre-treatment of Nrf2(+/+) MEFs with sulforaphane also protected against hydroperoxides (e.g. cumene hydroperoxide, CuOOH), free radical-generating compounds (e.g. menadione), and genotoxic electrophiles (e.g. chlorambucil).	sulforaphane	37-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
19303893-8	2009	In Nrf2(+/+) MEFs pre-treated with sulforaphane, BSO diminished intrinsic resistance and abolished inducible resistance to acrolein, CuOOH and chlorambucil, but not menadione.	sulforaphane	35-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	3-7
19303893-9	2009	Thus Nrf2-dependent up-regulation of GSH is the principal mechanism by which sulforaphane pre-treatment induced resistance to acrolein, CuOOH and chlorambucil, but not menadione.	sulforaphane	77-89	nuclear factor, erythroid derived 2, like 2	Mus musculus	5-9
19429419-5	2009	Sulforaphane significantly suppressed the expression of MDR1 and CYP3A mRNAs induced by atorvastatin lactone, lovastatin acid, and lovastatin lactone, comparable to the control level, and moderately inhibited that by cerivastatin acid, fluvastatin acid and simvastatin lactone.	sulforaphane	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-70
19459144-4	2009	Both MTBI and its oxidized derivative sulforaphane (SFN), which was found in the rocket seed at a low concentration, downregulated the expression of the proinflammatory genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23 p40, as well as that of intercellular adhesion molecule-1, in activated THP-1 cells.	sulforaphane	38-50	tumor necrosis factor	Homo sapiens	176-209
19459144-4	2009	Both MTBI and its oxidized derivative sulforaphane (SFN), which was found in the rocket seed at a low concentration, downregulated the expression of the proinflammatory genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23 p40, as well as that of intercellular adhesion molecule-1, in activated THP-1 cells.	sulforaphane	38-50	intercellular adhesion molecule 1	Homo sapiens	261-294
19459144-4	2009	Both MTBI and its oxidized derivative sulforaphane (SFN), which was found in the rocket seed at a low concentration, downregulated the expression of the proinflammatory genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23 p40, as well as that of intercellular adhesion molecule-1, in activated THP-1 cells.	sulforaphane	52-55	tumor necrosis factor	Homo sapiens	176-209
19459144-4	2009	Both MTBI and its oxidized derivative sulforaphane (SFN), which was found in the rocket seed at a low concentration, downregulated the expression of the proinflammatory genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23 p40, as well as that of intercellular adhesion molecule-1, in activated THP-1 cells.	sulforaphane	52-55	intercellular adhesion molecule 1	Homo sapiens	261-294
19287971-0	2009	Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	28-33
19287971-0	2009	Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells.	sulforaphane	0-12	mitogen-activated protein kinase 14	Homo sapiens	59-62
18942756-3	2009	This study tested the hypothesis that pre- or post-treatment of cultured cortical astrocytes with sulforaphane, an alkylating agent known to activate the NRF2 pathway of gene expression protects against death of astrocytes caused by transient exposure to O(2) and glucose deprivation (OGD).	sulforaphane	98-110	NFE2 like bZIP transcription factor 2	Rattus norvegicus	154-158
18942756-7	2009	Sulforaphane exposure was followed by an increase in cellular and nuclear NRF2 immunoreactivity.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	74-78
18942756-8	2009	Moreover, sulforaphane also increased the mRNA, protein level, and enzyme activity of NAD(P)H/Quinone Oxidoreductase1, a known target of NRF2 transcriptional activation.	sulforaphane	10-22	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	86-117
18942756-8	2009	Moreover, sulforaphane also increased the mRNA, protein level, and enzyme activity of NAD(P)H/Quinone Oxidoreductase1, a known target of NRF2 transcriptional activation.	sulforaphane	10-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	137-141
18942756-9	2009	We conclude that sulforaphane stimulates the NRF2 pathway of antioxidant gene expression in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion.	sulforaphane	17-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	45-49
19287971-2	2009	In this study, sulforaphane, a dietary isothiocyanate, down-regulated COX-2 expression in human bladder transitional cancer T24 cells at both transcriptional- and translational levels.	sulforaphane	15-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	70-75
19013013-9	2009	Furthermore, SUL successfully activated AhR transformation and its subsequent binding to the XRE.	sulforaphane	13-16	aryl hydrocarbon receptor	Homo sapiens	40-43
19287971-3	2009	Sulforaphane (5-20 microM) induced nuclear translocation of NF-kappaB and reduced its binding to the COX-2 promoter, a key mechanism for suppressing COX-2 expression by sulforaphane.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
19287971-3	2009	Sulforaphane (5-20 microM) induced nuclear translocation of NF-kappaB and reduced its binding to the COX-2 promoter, a key mechanism for suppressing COX-2 expression by sulforaphane.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154
19287971-3	2009	Sulforaphane (5-20 microM) induced nuclear translocation of NF-kappaB and reduced its binding to the COX-2 promoter, a key mechanism for suppressing COX-2 expression by sulforaphane.	sulforaphane	169-181	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
19287971-3	2009	Sulforaphane (5-20 microM) induced nuclear translocation of NF-kappaB and reduced its binding to the COX-2 promoter, a key mechanism for suppressing COX-2 expression by sulforaphane.	sulforaphane	169-181	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154
19287971-4	2009	Moreover, sulforaphane increased expression of p38 and phosphorylated-p38 protein.	sulforaphane	10-22	mitogen-activated protein kinase 14	Homo sapiens	47-50
19287971-4	2009	Moreover, sulforaphane increased expression of p38 and phosphorylated-p38 protein.	sulforaphane	10-22	mitogen-activated protein kinase 14	Homo sapiens	70-73
19287971-5	2009	A specific inhibitor of p38 MAPK, SB202190, was used to further investigate its pivotal role in sulforaphane-mediated down-regulation of COX-2.	sulforaphane	96-108	mitogen-activated protein kinase 14	Homo sapiens	24-27
19287971-5	2009	A specific inhibitor of p38 MAPK, SB202190, was used to further investigate its pivotal role in sulforaphane-mediated down-regulation of COX-2.	sulforaphane	96-108	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-142
19287971-6	2009	Exposure of T24 cells to SB202190 1 hour prior to sulforaphane treatment abolished the effect of sulforaphane on COX-2 mRNA down-regulation, but enhanced COX-2 transcription.	sulforaphane	50-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-118
19287971-6	2009	Exposure of T24 cells to SB202190 1 hour prior to sulforaphane treatment abolished the effect of sulforaphane on COX-2 mRNA down-regulation, but enhanced COX-2 transcription.	sulforaphane	97-109	prostaglandin-endoperoxide synthase 2	Homo sapiens	113-118
19287971-8	2009	Taken together, these data suggest that p38 is essential in sulforaphane-mediated COX-2 suppression and provide new insights into the molecular mechanisms of sulforaphane in the chemoprevention of bladder cancer.	sulforaphane	60-72	mitogen-activated protein kinase 14	Homo sapiens	40-43
19287971-8	2009	Taken together, these data suggest that p38 is essential in sulforaphane-mediated COX-2 suppression and provide new insights into the molecular mechanisms of sulforaphane in the chemoprevention of bladder cancer.	sulforaphane	60-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	82-87
19013013-0	2009	Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.	sulforaphane	0-12	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	21-27
19013013-0	2009	Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells.	sulforaphane	0-12	aryl-hydrocarbon receptor	Mus musculus	80-83
19013013-5	2009	Our results showed that SUL-induced CYP1A1 mRNA in a dose- and time-dependent manner.	sulforaphane	24-27	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	36-42
19013013-11	2009	This is the first demonstration that the broccoli-derived SUL can directly induce Cyp1a1 gene expression in an AhR-dependent manner and represents a novel mechanism by which SUL induces this enzyme.	sulforaphane	58-61	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
19013013-11	2009	This is the first demonstration that the broccoli-derived SUL can directly induce Cyp1a1 gene expression in an AhR-dependent manner and represents a novel mechanism by which SUL induces this enzyme.	sulforaphane	58-61	aryl hydrocarbon receptor	Homo sapiens	111-114
19013013-7	2009	Investigating the effect of SUL at the transcriptional level revealed that SUL increases the Cyp1a1 mRNA as early as 1h.	sulforaphane	75-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	93-99
19013013-11	2009	This is the first demonstration that the broccoli-derived SUL can directly induce Cyp1a1 gene expression in an AhR-dependent manner and represents a novel mechanism by which SUL induces this enzyme.	sulforaphane	174-177	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	82-88
19013013-11	2009	This is the first demonstration that the broccoli-derived SUL can directly induce Cyp1a1 gene expression in an AhR-dependent manner and represents a novel mechanism by which SUL induces this enzyme.	sulforaphane	174-177	aryl hydrocarbon receptor	Homo sapiens	111-114
19071154-1	2009	Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-174
19223537-0	2009	Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.	sulforaphane	0-12	tumor necrosis factor receptor superfamily, member 25	Mus musculus	74-79
19223537-1	2009	The present study shows that oral gavage of 6 mumol d,l-sulforaphane (SFN), a synthetic analogue of cruciferous vegetable-derived L isomer, thrice per week beginning at 6 weeks of age, significantly inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice without causing any side effects.	sulforaphane	52-68	tumor necrosis factor receptor superfamily, member 25	Mus musculus	260-265
19223537-1	2009	The present study shows that oral gavage of 6 mumol d,l-sulforaphane (SFN), a synthetic analogue of cruciferous vegetable-derived L isomer, thrice per week beginning at 6 weeks of age, significantly inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice without causing any side effects.	sulforaphane	70-73	tumor necrosis factor receptor superfamily, member 25	Mus musculus	260-265
19223537-6	2009	Additionally, SFN administration enhanced cytotoxicity of cocultures of natural killer (NK) cells and dendritic cells (DC) against TRAMP-C1 target cells, which correlated with infiltration of T cells in the neoplastic lesions and increased levels of interleukin-12 production by the DC.	sulforaphane	14-17	tumor necrosis factor receptor superfamily, member 25	Mus musculus	131-136
19223537-7	2009	In conclusion, the results of the present study indicate that SFN administration inhibits prostate cancer progression and pulmonary metastasis in TRAMP mice by reducing cell proliferation and augmenting NK cell lytic activity.	sulforaphane	62-65	tumor necrosis factor receptor superfamily, member 25	Mus musculus	146-151
18602823-0	2009	Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane.	sulforaphane	81-93	estrogen receptor 1	Homo sapiens	14-37
18602823-3	2009	Sulforaphane inhibited cell proliferation with IC(50) values at 24 and 48 h of 12.5 and 7.5 muM doses, respectively, and decreased ERalpha protein expression at concentrations between 2.5 and 30 muM.	sulforaphane	0-12	latexin	Homo sapiens	92-95
18602823-3	2009	Sulforaphane inhibited cell proliferation with IC(50) values at 24 and 48 h of 12.5 and 7.5 muM doses, respectively, and decreased ERalpha protein expression at concentrations between 2.5 and 30 muM.	sulforaphane	0-12	estrogen receptor 1	Homo sapiens	131-138
18602823-3	2009	Sulforaphane inhibited cell proliferation with IC(50) values at 24 and 48 h of 12.5 and 7.5 muM doses, respectively, and decreased ERalpha protein expression at concentrations between 2.5 and 30 muM.	sulforaphane	0-12	latexin	Homo sapiens	195-198
18844240-1	2009	The present study aimed to evaluate the growth-inhibitory effect of sulforaphane (SFN) and a traditional chemotherapy agent, 5-fluorouracil (5-Fu), against the proliferation of salivary gland adenoid cystic carcinoma high metastatic cell line (ACC-M) and low metastasis cell line (ACC-2).	sulforaphane	68-80	BCL2 related protein A1	Homo sapiens	281-286
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	glutathione S-transferase mu 1	Homo sapiens	198-226
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	glutathione S-transferase mu 1	Homo sapiens	228-233
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	glutathione S-transferase pi 1	Homo sapiens	236-264
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	glutathione S-transferase pi 1	Homo sapiens	266-271
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	crystallin zeta	Homo sapiens	280-302
19028145-3	2009	OBJECTIVE: We conducted a placebo-controlled dose escalation trial to investigate the in vivo effects of sulforaphane, a naturally occurring potent inducer of Phase II enzymes, on the expression of glutathione-s-transferase M1 (GSTM1), glutathione-s-transferase P1 (GSTP1), NADPH quinone oxidoreductase (NQO1), and hemoxygenase-1 (HO-1) in the upper airway of human subjects.	sulforaphane	105-117	NAD(P)H quinone dehydrogenase 1	Homo sapiens	304-308
19114066-5	2009	This report also examined the therapeutic effect of sulforaphane (SF) on the cochlear degeneration, which showed a protective effect on the tub-related retinal degeneration in our previous report.	sulforaphane	52-64	tubby bipartite transcription factor	Mus musculus	140-143
19114066-5	2009	This report also examined the therapeutic effect of sulforaphane (SF) on the cochlear degeneration, which showed a protective effect on the tub-related retinal degeneration in our previous report.	sulforaphane	66-68	tubby bipartite transcription factor	Mus musculus	140-143
19071154-1	2009	Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	176-180
19071154-1	2009	Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	152-174
19071154-1	2009	Sulforaphane (SFN) is an indirect antioxidant that protects animal tissues from chemical or biological insults by stimulating the expression of several NF-E2-related factor-2 (Nrf2)-regulated phase 2 enzymes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	176-180
19071154-3	2009	In this study, we investigated whether the activation of Nrf2 by SFN treatment or ectopic overexpression of Nrf2 inhibited cytokine-induced beta-cell damage.	sulforaphane	65-68	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
19071154-5	2009	Activation of Nrf2 by treatment with SFN and induction of Nrf2 overexpression by transfection with Nrf2 prevented cytokine toxicity.	sulforaphane	37-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
18823965-4	2009	Neither compound influenced the O-depentylation of pentoxyresorufin or CYP2B apoprotein levels, but sulforaphane caused a modest increase in CYP3A2 apoprotein levels.	sulforaphane	100-112	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	141-147
18952368-0	2009	Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3.	sulforaphane	0-12	tumor necrosis factor	Homo sapiens	24-33
18952368-0	2009	Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3.	sulforaphane	0-12	caspase 3	Homo sapiens	145-154
18952368-8	2009	In conclusion, the results of the present study indicate that SFN suppresses TNF-alpha-induced NF-kappaB activity and induces apoptosis through activation of ROS-dependent caspase-3.	sulforaphane	62-65	tumor necrosis factor	Homo sapiens	77-86
18952368-8	2009	In conclusion, the results of the present study indicate that SFN suppresses TNF-alpha-induced NF-kappaB activity and induces apoptosis through activation of ROS-dependent caspase-3.	sulforaphane	62-65	caspase 3	Homo sapiens	172-181
19034579-0	2009	Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells.	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
19183883-2	2009	The indirect antioxidant including sulforaphane (SFN) protects cells from oxidative damage by increasing the expression of Nrf2-target genes.	sulforaphane	35-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
18931336-8	2009	Sulforaphane pretreatment significantly limited lung RSV replication and virus-induced inflammation in Nrf2(+/+) but not in Nrf2(-/-) mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
19183883-2	2009	The indirect antioxidant including sulforaphane (SFN) protects cells from oxidative damage by increasing the expression of Nrf2-target genes.	sulforaphane	49-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
19202560-0	2009	Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.	sulforaphane	0-12	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
19202560-0	2009	Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene.	sulforaphane	0-12	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	50-56
19116884-0	2009	Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1).	sulforaphane	23-35	Kruppel like factor 4	Homo sapiens	15-19
18980980-5	2008	RESULTS: Sulforaphane enhanced the therapeutic potential of TRAIL in PC-3 cells and sensitized TRAIL-resistant LNCaP cells.	sulforaphane	9-21	TNF superfamily member 10	Homo sapiens	95-100
19116884-0	2009	Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1).	sulforaphane	23-35	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-83
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	185-221
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	223-226
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	227-231
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	0-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	232-236
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	185-221
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	223-226
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	227-231
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	14-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	232-236
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	18-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	185-221
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	18-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	223-226
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	18-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	227-231
19116884-1	2009	Sulforaphane (SF; 4-methylsulfinylbutyl isothiocyanate), a dietary compound derived from broccoli, may exhibit chemopreventive properties by inducing cell cycle arrest via induction of cyclin-dependent kinase inhibitor 1A (p21(waf1/cip1)), but the exact molecular mechanism has not been determined.	sulforaphane	18-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	232-236
18854174-4	2008	These DSBs were predominantly processed by homologous recombination repair (HRR), judging from the SFN concentration-dependent manner of Rad51 foci formation.	sulforaphane	99-102	RAD51 recombinase	Homo sapiens	137-142
18854174-5	2008	On the other hand, the phosphorylation of DNA-PKcs, a key non-homologous end joining (NHEJ) protein, was not observed by SFN treatment, suggesting that NHEJ may not be involved in DSBs induced by this chemical.	sulforaphane	121-124	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	42-50
18313257-4	2008	The sulforaphane-induced apoptosis in U937 cells correlated with the generation of intracellular ROS, collapse of MMP, activation of caspase-3, and down-regulation of anti-apoptotic Bcl-2 expression.	sulforaphane	4-16	caspase 3	Homo sapiens	133-142
18313257-4	2008	The sulforaphane-induced apoptosis in U937 cells correlated with the generation of intracellular ROS, collapse of MMP, activation of caspase-3, and down-regulation of anti-apoptotic Bcl-2 expression.	sulforaphane	4-16	BCL2 apoptosis regulator	Homo sapiens	182-187
18313257-5	2008	The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against sulforaphane-elicited ROS generation, disruption of the MMP, caspase-3 activation and apoptosis.	sulforaphane	110-122	caspase 3	Homo sapiens	171-180
18980980-0	2008	Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	51-56
18980980-1	2008	PURPOSE: The purpose of this study was to examine the molecular mechanisms by which sulforaphane enhances the therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in prostate cancer.	sulforaphane	84-96	TNF superfamily member 10	Homo sapiens	135-190
18980980-1	2008	PURPOSE: The purpose of this study was to examine the molecular mechanisms by which sulforaphane enhances the therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in prostate cancer.	sulforaphane	84-96	TNF superfamily member 10	Homo sapiens	192-197
18980980-5	2008	RESULTS: Sulforaphane enhanced the therapeutic potential of TRAIL in PC-3 cells and sensitized TRAIL-resistant LNCaP cells.	sulforaphane	9-21	TNF superfamily member 10	Homo sapiens	60-65
18980980-6	2008	Sulforaphane-induced apoptosis in PC-3 cells correlated with the generation of intracellular reactive oxygen species (ROS), collapse of mitochondrial membrane potential, activation of caspase-3 and caspase-9, and up-regulation of DR4 and DR5.	sulforaphane	0-12	caspase 3	Homo sapiens	184-193
18980980-6	2008	Sulforaphane-induced apoptosis in PC-3 cells correlated with the generation of intracellular reactive oxygen species (ROS), collapse of mitochondrial membrane potential, activation of caspase-3 and caspase-9, and up-regulation of DR4 and DR5.	sulforaphane	0-12	caspase 9	Homo sapiens	198-207
18980980-6	2008	Sulforaphane-induced apoptosis in PC-3 cells correlated with the generation of intracellular reactive oxygen species (ROS), collapse of mitochondrial membrane potential, activation of caspase-3 and caspase-9, and up-regulation of DR4 and DR5.	sulforaphane	0-12	TNF receptor superfamily member 10a	Homo sapiens	230-233
18980980-6	2008	Sulforaphane-induced apoptosis in PC-3 cells correlated with the generation of intracellular reactive oxygen species (ROS), collapse of mitochondrial membrane potential, activation of caspase-3 and caspase-9, and up-regulation of DR4 and DR5.	sulforaphane	0-12	TNF receptor superfamily member 10b	Homo sapiens	238-241
18980980-7	2008	Sulforaphane induced the expression of Bax, Bak, Bim, and Noxa and inhibited the expression of Bcl-2, Bcl-X(L), and Mcl-1.	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
18980980-7	2008	Sulforaphane induced the expression of Bax, Bak, Bim, and Noxa and inhibited the expression of Bcl-2, Bcl-X(L), and Mcl-1.	sulforaphane	0-12	BCL2 antagonist/killer 1	Homo sapiens	44-47
18725505-10	2008	At concentrations (5 and 10 microM) that did not down-regulate PXR gene expression and were not cytotoxic, L-sulforaphane (an hPXR antagonist) decreased CYP3A4, CYP3A5, and ABCB1 gene expression in cells treated with G. biloba extract.	sulforaphane	107-121	nuclear receptor subfamily 1 group I member 2	Homo sapiens	126-130
18980980-7	2008	Sulforaphane induced the expression of Bax, Bak, Bim, and Noxa and inhibited the expression of Bcl-2, Bcl-X(L), and Mcl-1.	sulforaphane	0-12	BCL2 apoptosis regulator	Homo sapiens	95-100
18725505-10	2008	At concentrations (5 and 10 microM) that did not down-regulate PXR gene expression and were not cytotoxic, L-sulforaphane (an hPXR antagonist) decreased CYP3A4, CYP3A5, and ABCB1 gene expression in cells treated with G. biloba extract.	sulforaphane	107-121	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	173-178
18980980-7	2008	Sulforaphane induced the expression of Bax, Bak, Bim, and Noxa and inhibited the expression of Bcl-2, Bcl-X(L), and Mcl-1.	sulforaphane	0-12	BCL2 like 1	Homo sapiens	102-110
18980980-7	2008	Sulforaphane induced the expression of Bax, Bak, Bim, and Noxa and inhibited the expression of Bcl-2, Bcl-X(L), and Mcl-1.	sulforaphane	0-12	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	116-121
18980980-8	2008	The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against sulforaphane-induced ROS generation, mitochondrial membrane potential disruption, caspase-3 activation, and apoptosis.	sulforaphane	110-122	caspase 3	Homo sapiens	192-201
18980980-9	2008	Sulforaphane inhibited growth of orthotopically implanted PC-3 tumors by inducing apoptosis and inhibiting proliferation and also enhanced the antitumor activity of TRAIL.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	165-170
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	TNF receptor superfamily member 10a	Homo sapiens	45-53
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	TNF receptor superfamily member 10a	Homo sapiens	54-57
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	TNF receptor superfamily member 10b	Homo sapiens	59-67
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	TNF receptor superfamily member 10b	Homo sapiens	68-71
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	73-76
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	BCL2 antagonist/killer 1	Homo sapiens	81-84
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	mitogen-activated protein kinase kinase 7	Homo sapiens	152-155
18980980-10	2008	Sulforaphane up-regulated the expressions of TRAIL-R1/DR4, TRAIL-R2/DR5, Bax and Bak and inhibited the activation of nuclear factor-kappaB P13K/AKT and MEK/ERK pathways in tumor tissues.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	156-159
18980980-11	2008	The combination of sulforaphane and TRAIL was more effective in inhibiting markers of angiogenesis and metastasis and activating FOXO3a transcription factor than single agent alone.	sulforaphane	19-31	forkhead box O3	Homo sapiens	129-135
18980980-12	2008	CONCLUSIONS: The ability of sulforaphane to inhibit tumor growth, metastasis, and angiogenesis and to enhance the therapeutic potential of TRAIL suggests that sulforaphane alone or in combination with TRAIL can be used for the management of prostate cancer.	sulforaphane	28-40	TNF superfamily member 10	Homo sapiens	201-206
18980980-12	2008	CONCLUSIONS: The ability of sulforaphane to inhibit tumor growth, metastasis, and angiogenesis and to enhance the therapeutic potential of TRAIL suggests that sulforaphane alone or in combination with TRAIL can be used for the management of prostate cancer.	sulforaphane	159-171	TNF superfamily member 10	Homo sapiens	139-144
18755157-0	2008	Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	89-93
18755157-7	2008	We concluded that SFN exerts its anti-inflammatory activity mainly via activation of Nrf2 in mouse peritoneal macrophages.	sulforaphane	18-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
18607771-3	2008	Sulforaphane also increased levels/activities of SOD, catalase, GSH and GST in isolated mitochondria of aortic smooth muscle cells.	sulforaphane	0-12	catalase	Rattus norvegicus	54-62
18607771-3	2008	Sulforaphane also increased levels/activities of SOD, catalase, GSH and GST in isolated mitochondria of aortic smooth muscle cells.	sulforaphane	0-12	hematopoietic prostaglandin D synthase	Rattus norvegicus	72-75
18607771-4	2008	Time-dependent sulforaphane-induced increases in the mRNA levels for MnSOD, catalase, the catalytic subunit of gamma-glutamylcysteine ligase, GR, GST-A1, GST-P1, and NQO1 were observed.	sulforaphane	15-27	superoxide dismutase 2	Rattus norvegicus	69-74
18607771-4	2008	Time-dependent sulforaphane-induced increases in the mRNA levels for MnSOD, catalase, the catalytic subunit of gamma-glutamylcysteine ligase, GR, GST-A1, GST-P1, and NQO1 were observed.	sulforaphane	15-27	catalase	Rattus norvegicus	76-84
18607771-4	2008	Time-dependent sulforaphane-induced increases in the mRNA levels for MnSOD, catalase, the catalytic subunit of gamma-glutamylcysteine ligase, GR, GST-A1, GST-P1, and NQO1 were observed.	sulforaphane	15-27	glutathione-disulfide reductase	Rattus norvegicus	142-144
18607771-4	2008	Time-dependent sulforaphane-induced increases in the mRNA levels for MnSOD, catalase, the catalytic subunit of gamma-glutamylcysteine ligase, GR, GST-A1, GST-P1, and NQO1 were observed.	sulforaphane	15-27	glutathione S-transferase alpha 1	Rattus norvegicus	146-152
18607771-4	2008	Time-dependent sulforaphane-induced increases in the mRNA levels for MnSOD, catalase, the catalytic subunit of gamma-glutamylcysteine ligase, GR, GST-A1, GST-P1, and NQO1 were observed.	sulforaphane	15-27	glutathione S-transferase pi 1	Rattus norvegicus	154-160
18607771-4	2008	Time-dependent sulforaphane-induced increases in the mRNA levels for MnSOD, catalase, the catalytic subunit of gamma-glutamylcysteine ligase, GR, GST-A1, GST-P1, and NQO1 were observed.	sulforaphane	15-27	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	166-170
18633117-1	2008	OBJECTIVE: Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE).	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Homo sapiens	64-86
18633117-9	2008	This also abolished the counteracting effect of sulforaphane, suggesting mediation by nrf2 and related increase of transketolase expression.	sulforaphane	48-60	transketolase	Homo sapiens	115-128
18633117-1	2008	OBJECTIVE: Sulforaphane is an activator of transcription factor NF-E2-related factor-2 (nrf2) that regulates gene expression through the promoter antioxidant response element (ARE).	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
18633117-3	2008	The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia.	sulforaphane	66-78	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
18633117-6	2008	RESULTS: Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase.	sulforaphane	31-43	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
18633117-6	2008	RESULTS: Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase.	sulforaphane	31-43	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
18633117-6	2008	RESULTS: Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase.	sulforaphane	31-43	transketolase	Homo sapiens	180-193
18633117-6	2008	RESULTS: Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase.	sulforaphane	31-43	glutathione-disulfide reductase	Homo sapiens	198-219
18633117-9	2008	This also abolished the counteracting effect of sulforaphane, suggesting mediation by nrf2 and related increase of transketolase expression.	sulforaphane	48-60	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
18761713-4	2008	In both neurons and glia, Nrf2 expression and treatment with chemopreventive Nrf2 activators, including D3T and sulforaphane, up-regulates sulfiredoxin, an enzyme responsible for reducing hyperoxidized peroxiredoxins.	sulforaphane	112-124	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
18373608-0	2008	The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells.	sulforaphane	42-54	histone deacetylase 9	Homo sapiens	12-31
18373608-0	2008	The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells.	sulforaphane	42-54	defensin beta 4A	Homo sapiens	69-84
18373608-2	2008	The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection.	sulforaphane	50-62	histone deacetylase 9	Homo sapiens	12-31
18373608-2	2008	The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection.	sulforaphane	50-62	histone deacetylase 9	Homo sapiens	33-37
18373608-2	2008	The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection.	sulforaphane	64-67	histone deacetylase 9	Homo sapiens	12-31
18373608-2	2008	The dietary histone deacetylase (HDAC) inhibitors sulforaphane (SFN) and butyrate have received a great deal of attention because of their ability to simultaneously modulate multiple cellular targets involved in cellular protection.	sulforaphane	64-67	histone deacetylase 9	Homo sapiens	33-37
18373608-3	2008	In this study the influence of SFN and butyrate on HBD-2 expression as well as the molecular pathways involved in SFN-mediated induction of HBD-2 were scrutinized.	sulforaphane	114-117	defensin beta 4A	Homo sapiens	140-145
18373608-11	2008	The data clearly demonstrate for the first time that the dietary HDAC inhibitor SFN is able to induce antimicrobial peptides in colonocytes.	sulforaphane	80-83	histone deacetylase 9	Homo sapiens	65-69
18761713-4	2008	In both neurons and glia, Nrf2 expression and treatment with chemopreventive Nrf2 activators, including D3T and sulforaphane, up-regulates sulfiredoxin, an enzyme responsible for reducing hyperoxidized peroxiredoxins.	sulforaphane	112-124	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
18579710-7	2008	We have also used our computational pharmacophore and docking tools to suggest that most of the known PXR antagonists, such as coumestrol and sulforaphane, could also interact on the outer surface of PXR at the AF-2 domain.	sulforaphane	142-154	nuclear receptor subfamily 1 group I member 2	Homo sapiens	102-105
26050183-3	2008	Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.	sulforaphane	16-28	thioredoxin reductase 1	Homo sapiens	62-85
26050183-6	2008	Sulforaphane, erucin and iberin up-regulate thioredoxin reductase expression in human MCF-7 cells.	sulforaphane	0-12	peroxiredoxin 5	Homo sapiens	44-65
18556627-9	2008	Interestingly, targeting KEAP1 by siRNA or the small-molecule activator sulforaphane restored induction of NRF2-dependent antioxidants in DJ-1-disrupted cells in response to cigarette smoke.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
18556627-9	2008	Interestingly, targeting KEAP1 by siRNA or the small-molecule activator sulforaphane restored induction of NRF2-dependent antioxidants in DJ-1-disrupted cells in response to cigarette smoke.	sulforaphane	72-84	Parkinsonism associated deglycase	Homo sapiens	138-142
18561315-0	2008	Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	37-68
18561315-8	2008	In our study, we investigated the effects of sulforaphane on expression of hypoxia-inducible factor-1alpha (HIF-1alpha), which was overexpressed in many human malignant tumors, human tongue squamous cell carcinoma and prostate cancer DU145 cells.	sulforaphane	45-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-106
18561315-8	2008	In our study, we investigated the effects of sulforaphane on expression of hypoxia-inducible factor-1alpha (HIF-1alpha), which was overexpressed in many human malignant tumors, human tongue squamous cell carcinoma and prostate cancer DU145 cells.	sulforaphane	45-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
18561315-9	2008	Sulforaphane inhibited hypoxia induced expression of HIF-1alpha via inhibiting synthesis of HIF-1alpha.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	53-63
18561315-9	2008	Sulforaphane inhibited hypoxia induced expression of HIF-1alpha via inhibiting synthesis of HIF-1alpha.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	92-102
18561315-10	2008	Sulforaphane was also found to inhibit hypoxia induced HIF-1alpha expression through activating JNK and ERK signaling pathways, but not AKT pathway.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
18561315-10	2008	Sulforaphane was also found to inhibit hypoxia induced HIF-1alpha expression through activating JNK and ERK signaling pathways, but not AKT pathway.	sulforaphane	0-12	mitogen-activated protein kinase 8	Homo sapiens	96-99
18561315-11	2008	Inhibition of HIF-1alpha by sulforaphane resulted in decreasing expression of VEGF.	sulforaphane	28-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
18561315-11	2008	Inhibition of HIF-1alpha by sulforaphane resulted in decreasing expression of VEGF.	sulforaphane	28-40	vascular endothelial growth factor A	Homo sapiens	78-82
18561315-12	2008	Taken together, these results suggest that sulforaphane is an effective chemopreventive compound against tongue cancers and prostate cell angiogenesis in vitro, and that the HIF-1alpha target provides a new sight into the mechanisms of sulforaphane"s inhibition against tumor cell proliferation.	sulforaphane	236-248	hypoxia inducible factor 1 subunit alpha	Homo sapiens	174-184
18619545-5	2008	Lithium, a GSK-3beta inhibitor, promoted Nrf2 transcriptional activity towards an Antioxidant-Response-Element (ARE) luciferase reporter and cooperated with sulforaphane (SFN) to induce this reporter and to increase the protein levels of heme oxygenase-1 (HO-1), coded by a representative ARE-containing gene.	sulforaphane	171-174	heme oxygenase 1	Mus musculus	238-254
18619545-6	2008	Conversely, ARE activation by SFN was attenuated by over-expression of active GSK-3beta.	sulforaphane	30-33	glycogen synthase kinase 3 beta	Mus musculus	78-87
18579710-7	2008	We have also used our computational pharmacophore and docking tools to suggest that most of the known PXR antagonists, such as coumestrol and sulforaphane, could also interact on the outer surface of PXR at the AF-2 domain.	sulforaphane	142-154	nuclear receptor subfamily 1 group I member 2	Homo sapiens	200-203
18636164-0	2008	Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane.	sulforaphane	168-180	interleukin 6	Homo sapiens	71-75
18636164-11	2008	Furthermore, sulforaphane also inhibits norepinephrine-mediated increase of the IL-6 levels but not VEGF levels.	sulforaphane	13-25	interleukin 6	Homo sapiens	80-84
18636164-12	2008	Our study is the first to demonstrate that stress-associated hormone, norepinephrine, can increase the cell proliferation and IL-6 levels of human pancreatic duct epithelial cells, which can be inhibited by sulforaphane, a chemopreventive agent and a natural compound from the Cruciferous vegetables.	sulforaphane	207-219	interleukin 6	Homo sapiens	126-130
18566435-5	2008	Animals treated with sulforaphane displayed a 2-3-fold increase in heme oxygenase-1, a reduced abundance of microglial cells in the hippocampus and an attenuated production of inflammation markers (inducible NO synthase, IL-6, and TNF-alpha) in response to LPS.	sulforaphane	21-33	heme oxygenase 1	Mus musculus	67-83
18622263-8	2008	In HepG2 cells, the UGT2B7 protein level and morphine glucuronosyltransferase activity were also significantly induced by SFN.	sulforaphane	122-125	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	20-26
18417180-6	2008	Similar to tert-butylhydroquinone (tBHQ) or sulforaphane (SF), arsenic induced the Nrf2-dependent response through enhancing Nrf2 protein levels by inhibiting Nrf2 ubiquitination and degradation.	sulforaphane	58-60	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
18417180-9	2008	Furthermore, induction of Nrf2 by arsenic is independent of the previously identified C151 residue in Keap1 that is required for Nrf2 activation by tBHQ or SF.	sulforaphane	156-158	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
18417180-9	2008	Furthermore, induction of Nrf2 by arsenic is independent of the previously identified C151 residue in Keap1 that is required for Nrf2 activation by tBHQ or SF.	sulforaphane	156-158	kelch like ECH associated protein 1	Homo sapiens	102-107
18596959-7	2008	We also provide evidence that sulforaphane (the isothiocyanate derived from 4-methylsuphinylbutyl glucosinolate that accumulates in broccoli) chemically interacts with TGFbeta1, EGF and insulin peptides to form thioureas, and enhances TGFbeta1/Smad-mediated transcription.	sulforaphane	30-42	transforming growth factor beta 1	Homo sapiens	168-176
18596959-7	2008	We also provide evidence that sulforaphane (the isothiocyanate derived from 4-methylsuphinylbutyl glucosinolate that accumulates in broccoli) chemically interacts with TGFbeta1, EGF and insulin peptides to form thioureas, and enhances TGFbeta1/Smad-mediated transcription.	sulforaphane	30-42	epidermal growth factor	Homo sapiens	178-181
18596959-7	2008	We also provide evidence that sulforaphane (the isothiocyanate derived from 4-methylsuphinylbutyl glucosinolate that accumulates in broccoli) chemically interacts with TGFbeta1, EGF and insulin peptides to form thioureas, and enhances TGFbeta1/Smad-mediated transcription.	sulforaphane	30-42	transforming growth factor beta 1	Homo sapiens	235-243
18566435-5	2008	Animals treated with sulforaphane displayed a 2-3-fold increase in heme oxygenase-1, a reduced abundance of microglial cells in the hippocampus and an attenuated production of inflammation markers (inducible NO synthase, IL-6, and TNF-alpha) in response to LPS.	sulforaphane	21-33	nitric oxide synthase 2, inducible	Mus musculus	198-219
18566435-5	2008	Animals treated with sulforaphane displayed a 2-3-fold increase in heme oxygenase-1, a reduced abundance of microglial cells in the hippocampus and an attenuated production of inflammation markers (inducible NO synthase, IL-6, and TNF-alpha) in response to LPS.	sulforaphane	21-33	interleukin 6	Mus musculus	221-225
18566435-5	2008	Animals treated with sulforaphane displayed a 2-3-fold increase in heme oxygenase-1, a reduced abundance of microglial cells in the hippocampus and an attenuated production of inflammation markers (inducible NO synthase, IL-6, and TNF-alpha) in response to LPS.	sulforaphane	21-33	tumor necrosis factor	Mus musculus	231-240
18435488-0	2008	The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis.	sulforaphane	17-29	matrix metallopeptidase 9	Homo sapiens	39-65
18407246-0	2008	Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
18407246-2	2008	Sulforaphane, which is a naturally occurring isothiocyanate that is present in cruciferous vegetables such as broccoli, is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	181-185
18407246-4	2008	Therefore, we evaluated the preactivation of Nrf2 by sulforaphane to determine if it could inhibit ischemia-reperfusion-induced kidney damage.	sulforaphane	53-65	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
18407246-5	2008	Treatment of HK2 renal tubular epithelial cells with sulforaphane effectively protected cells against cytotoxicity induced by hypoxia-reoxygenation, and sulforaphane dramatically induced phase 2 enzymes by decreasing the Keap1 protein levels and increasing Nrf2 nuclear translocation.	sulforaphane	53-65	hexokinase 2	Homo sapiens	13-16
18407246-5	2008	Treatment of HK2 renal tubular epithelial cells with sulforaphane effectively protected cells against cytotoxicity induced by hypoxia-reoxygenation, and sulforaphane dramatically induced phase 2 enzymes by decreasing the Keap1 protein levels and increasing Nrf2 nuclear translocation.	sulforaphane	53-65	NFE2 like bZIP transcription factor 2	Homo sapiens	257-261
18407246-5	2008	Treatment of HK2 renal tubular epithelial cells with sulforaphane effectively protected cells against cytotoxicity induced by hypoxia-reoxygenation, and sulforaphane dramatically induced phase 2 enzymes by decreasing the Keap1 protein levels and increasing Nrf2 nuclear translocation.	sulforaphane	153-165	hexokinase 2	Homo sapiens	13-16
18407246-5	2008	Treatment of HK2 renal tubular epithelial cells with sulforaphane effectively protected cells against cytotoxicity induced by hypoxia-reoxygenation, and sulforaphane dramatically induced phase 2 enzymes by decreasing the Keap1 protein levels and increasing Nrf2 nuclear translocation.	sulforaphane	153-165	kelch like ECH associated protein 1	Homo sapiens	221-226
18407246-5	2008	Treatment of HK2 renal tubular epithelial cells with sulforaphane effectively protected cells against cytotoxicity induced by hypoxia-reoxygenation, and sulforaphane dramatically induced phase 2 enzymes by decreasing the Keap1 protein levels and increasing Nrf2 nuclear translocation.	sulforaphane	153-165	NFE2 like bZIP transcription factor 2	Homo sapiens	257-261
18407246-6	2008	Additionally, a second set of experiments using a renal ischemia-reperfusion model produced results that were essentially the same as those observed when HK2 cells were used; namely, that sulforaphane induced Nrf2-dependent phase 2 enzymes and thereby improved ischemia-reperfusion-induced changes in the lipid hydroperoxides, glutathione, creatinine clearance, kidney weight, and histologic abnormalities.	sulforaphane	188-200	hexokinase 2	Homo sapiens	154-157
18407246-6	2008	Additionally, a second set of experiments using a renal ischemia-reperfusion model produced results that were essentially the same as those observed when HK2 cells were used; namely, that sulforaphane induced Nrf2-dependent phase 2 enzymes and thereby improved ischemia-reperfusion-induced changes in the lipid hydroperoxides, glutathione, creatinine clearance, kidney weight, and histologic abnormalities.	sulforaphane	188-200	NFE2 like bZIP transcription factor 2	Homo sapiens	209-213
18435488-4	2008	Sulforaphane (SFN), an isothiocyanate present in broccoli which exhibits chemopreventive properties, selectively inhibited the secretion of MMP-9 but not that of MMP-2.	sulforaphane	0-12	matrix metallopeptidase 9	Homo sapiens	140-145
18435488-4	2008	Sulforaphane (SFN), an isothiocyanate present in broccoli which exhibits chemopreventive properties, selectively inhibited the secretion of MMP-9 but not that of MMP-2.	sulforaphane	0-12	matrix metallopeptidase 2	Homo sapiens	162-167
18435488-4	2008	Sulforaphane (SFN), an isothiocyanate present in broccoli which exhibits chemopreventive properties, selectively inhibited the secretion of MMP-9 but not that of MMP-2.	sulforaphane	14-17	matrix metallopeptidase 9	Homo sapiens	140-145
18204073-4	2008	Compared with parental cells, expression of GSTP1-1 alone enhanced the rate of intracellular accumulation of SFN and its glutathione conjugate, SFN-SG--an effect that was associated with increased ARE-containing reporter gene induction.	sulforaphane	109-112	glutathione S-transferase pi 1	Homo sapiens	44-51
18325578-0	2008	Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.	sulforaphane	19-31	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
18325578-0	2008	Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells.	sulforaphane	19-31	heart and neural crest derivatives expressed 1	Mus musculus	69-74
18204073-5	2008	Expression of MRP1 greatly reduced SFN/SFN-SG accumulation and resulted in significant attenuation of SFN-mediated induction of ARE-containing reporter and endogenous gene expression.	sulforaphane	35-38	ATP binding cassette subfamily C member 1	Homo sapiens	14-18
18204073-0	2008	Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.	sulforaphane	122-134	ATP binding cassette subfamily C member 1	Homo sapiens	14-18
18204073-0	2008	Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane.	sulforaphane	122-134	glutathione S-transferase pi 1	Homo sapiens	23-30
18204073-7	2008	Depletion of GSH prior to SFN treatment or the substitution of tert-butylhydroquinone for SFN abolished the effects of MRP1/GSTP1-1 on ARE-containing gene induction-indicating that these effects are GSH dependent.	sulforaphane	90-93	ATP binding cassette subfamily C member 1	Homo sapiens	119-123
18204073-2	2008	Because SFN is a reactive electrophile--readily forming conjugates with glutathione (GSH)--we asked whether expression of glutathione S-transferase (GST) P1-1 and the GSH conjugate efflux pump, multidrug resistance or resistance-associated protein (MRP) 1, would significantly modify the cellular response to SFN exposure.	sulforaphane	8-11	glutathione S-transferase pi 1	Homo sapiens	122-158
18204073-7	2008	Depletion of GSH prior to SFN treatment or the substitution of tert-butylhydroquinone for SFN abolished the effects of MRP1/GSTP1-1 on ARE-containing gene induction-indicating that these effects are GSH dependent.	sulforaphane	90-93	glutathione S-transferase pi 1	Homo sapiens	124-131
18204073-2	2008	Because SFN is a reactive electrophile--readily forming conjugates with glutathione (GSH)--we asked whether expression of glutathione S-transferase (GST) P1-1 and the GSH conjugate efflux pump, multidrug resistance or resistance-associated protein (MRP) 1, would significantly modify the cellular response to SFN exposure.	sulforaphane	8-11	ATP binding cassette subfamily C member 1	Homo sapiens	194-255
17618109-0	2008	Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines.	sulforaphane	0-12	ATP binding cassette subfamily C member 1	Homo sapiens	33-37
18160582-3	2008	We have demonstrated that sFn inhibited monocyte adherence and cytotoxicity by a mechanism involving blockade of monocyte alphaMbeta2 and tumor cell CD54.	sulforaphane	26-29	intercellular adhesion molecule 1	Homo sapiens	149-153
18160582-4	2008	It was, therefore, hypothesized that sFn also inhibits lymphocyte and interleukin-2-activated lymphocyte (LAK) adherence and cytotoxicity against tumor cells.	sulforaphane	37-40	alpha kinase 1	Homo sapiens	106-109
18160582-6	2008	Lymphocyte and LAK cell adherence and cytotoxicity, which was adherence dependent, were inhibited by preincubation with purified or plasma-derived sFn.	sulforaphane	147-150	alpha kinase 1	Homo sapiens	15-18
18385090-2	2008	METHODS: Cultured ARPE-19 cells were treated with different concentrations of PI3K inhibitors, followed by exposure to sulforaphane, an Nrf2 inducer.	sulforaphane	119-131	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
18385090-12	2008	LY294002 also inhibited sulforaphane-induced Nrf2 nuclear translocation.	sulforaphane	24-36	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
17618109-0	2008	Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines.	sulforaphane	0-12	ATP binding cassette subfamily C member 2	Homo sapiens	42-46
17913594-6	2008	Examples include: activation of the Nrf-2 -- ARE pathway by sulforaphane and curcumin; activation of TRP ion channels by allicin and capsaicin; and activation of sirtuin-1 by resveratrol.	sulforaphane	60-72	NFE2 like bZIP transcription factor 2	Homo sapiens	36-41
17657594-6	2008	Interestingly, co-treatment with 20units/ml of SOD, a free radical scavenger, attenuated the synergism elicited by the combinations (2-fold with 25 muM SFN and 20 muM EGCG; and 15-fold with 25 microM SFN and 100 microM EGCG).	sulforaphane	152-155	superoxide dismutase 1	Homo sapiens	47-50
17657594-6	2008	Interestingly, co-treatment with 20units/ml of SOD, a free radical scavenger, attenuated the synergism elicited by the combinations (2-fold with 25 muM SFN and 20 muM EGCG; and 15-fold with 25 microM SFN and 100 microM EGCG).	sulforaphane	200-203	superoxide dismutase 1	Homo sapiens	47-50
17657594-15	2008	CONCLUSION: Taken together, the synergistic activation of AP-1 by the combination of SFN and EGCG that was potentiated by HDAC inhibitor TSA and attenuated by free radical scavenger SOD point to a possible multifactorial control of colon carcinoma that may involve a role for HDACs, inhibition of cellular senescence, and SOD signaling.	sulforaphane	85-88	superoxide dismutase 1	Homo sapiens	182-185
17657594-15	2008	CONCLUSION: Taken together, the synergistic activation of AP-1 by the combination of SFN and EGCG that was potentiated by HDAC inhibitor TSA and attenuated by free radical scavenger SOD point to a possible multifactorial control of colon carcinoma that may involve a role for HDACs, inhibition of cellular senescence, and SOD signaling.	sulforaphane	85-88	superoxide dismutase 1	Homo sapiens	322-325
17962605-6	2007	Sulforaphane was used to activate Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
18090122-0	2007	Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.	sulforaphane	12-24	mitogen-activated protein kinase 14	Homo sapiens	40-43
18090122-0	2007	Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.	sulforaphane	12-24	caspase 7	Homo sapiens	59-68
18090122-0	2007	Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells.	sulforaphane	12-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	100-105
18090122-3	2007	Sulforaphane reduced proliferation in MCF-7 cells and inhibited cyclooxygenase-2 expression in M13SV1 cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA).	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-80
18090122-4	2007	The chemopreventive effects of sulforaphane were associated with p38 mitogen-activated protein kinase suggest its important role in cell survival/apoptosis regulation and stabilization of cyclooxygenase-2.	sulforaphane	31-43	mitogen-activated protein kinase 14	Homo sapiens	65-68
18090122-4	2007	The chemopreventive effects of sulforaphane were associated with p38 mitogen-activated protein kinase suggest its important role in cell survival/apoptosis regulation and stabilization of cyclooxygenase-2.	sulforaphane	31-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	188-204
18090122-5	2007	Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells.	sulforaphane	0-12	mitogen-activated protein kinase 14	Homo sapiens	25-28
18090122-5	2007	Sulforaphane upregulates p38 in MCF-7 cells and prevented TPA-reduced phosphorylation of p38 in M13SV1 cells, but activated caspase-7 associated with apoptosis in MCF-7 cells.	sulforaphane	0-12	mitogen-activated protein kinase 14	Homo sapiens	89-92
18090122-6	2007	These results suggest that sulforaphane may be an alternative candidate for targeted prevention of ER-positive and cyclooxygenase-2-induced phenotypes and breast cancer.	sulforaphane	27-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	115-131
18248854-0	2008	Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells.	sulforaphane	0-12	intercellular adhesion molecule 1	Homo sapiens	68-74
18248854-0	2008	Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	79-88
18248854-6	2008	The intracellular GSH levels in SFN-treated ECs were observed to be reduced, the time course coincident with the suppression of P65 translocation and IkappaB-alpha degradation.	sulforaphane	32-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	128-131
18248854-6	2008	The intracellular GSH levels in SFN-treated ECs were observed to be reduced, the time course coincident with the suppression of P65 translocation and IkappaB-alpha degradation.	sulforaphane	32-35	NFKB inhibitor alpha	Homo sapiens	150-163
18248854-7	2008	NAC and GSH reverse the inhibitory effects of SFN upon p65 translocation and IkappaB-alpha degradation when preincubated with this agent.	sulforaphane	46-49	synuclein alpha	Homo sapiens	0-3
18248854-7	2008	NAC and GSH reverse the inhibitory effects of SFN upon p65 translocation and IkappaB-alpha degradation when preincubated with this agent.	sulforaphane	46-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	55-58
17854798-8	2007	Involvement of the ERK1/2 cascade in inducible ARE-transcription activities was also observed in cells treated with other types of inducers oltipraz, sulforaphane and hydrogen peroxide.	sulforaphane	150-162	mitogen-activated protein kinase 3	Mus musculus	19-25
17996688-0	2007	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	51-67
17996688-0	2007	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	69-74
17996688-0	2007	Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	133-138
17996688-3	2007	The mechanism by which sulforaphane suppresses COX-2 expression remains poorly understood.	sulforaphane	23-35	prostaglandin-endoperoxide synthase 2	Mus musculus	47-52
17996688-4	2007	In the present report, we investigated the effect of sulforaphane on the expression of COX-2 in lipopolysaccharide (LPS)-activated Raw 264.7 cells.	sulforaphane	53-65	prostaglandin-endoperoxide synthase 2	Mus musculus	87-92
17996688-5	2007	Sulforaphane significantly suppressed the LPS-induced COX-2 protein and mRNA expression in a dose-dependent manner.	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	54-59
17996688-6	2007	The ability of sulforaphane to suppress the expression of the COX-2 was investigated using luciferase reporters controlled by various cis-elements in COX-2 promoter region.	sulforaphane	15-27	prostaglandin-endoperoxide synthase 2	Mus musculus	62-67
17996688-6	2007	The ability of sulforaphane to suppress the expression of the COX-2 was investigated using luciferase reporters controlled by various cis-elements in COX-2 promoter region.	sulforaphane	15-27	prostaglandin-endoperoxide synthase 2	Mus musculus	150-155
17996688-7	2007	Electrophoretic mobility shift assay (EMSA) verified that NF-kappaB, C/EBP, CREB and AP-1 were identified as responsible for the sulforaphane-mediated COX-2 down-regulation.	sulforaphane	129-141	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	58-67
17996688-7	2007	Electrophoretic mobility shift assay (EMSA) verified that NF-kappaB, C/EBP, CREB and AP-1 were identified as responsible for the sulforaphane-mediated COX-2 down-regulation.	sulforaphane	129-141	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	69-74
17996688-7	2007	Electrophoretic mobility shift assay (EMSA) verified that NF-kappaB, C/EBP, CREB and AP-1 were identified as responsible for the sulforaphane-mediated COX-2 down-regulation.	sulforaphane	129-141	cAMP responsive element binding protein 1	Mus musculus	76-80
17996688-7	2007	Electrophoretic mobility shift assay (EMSA) verified that NF-kappaB, C/EBP, CREB and AP-1 were identified as responsible for the sulforaphane-mediated COX-2 down-regulation.	sulforaphane	129-141	jun proto-oncogene	Mus musculus	85-89
17996688-7	2007	Electrophoretic mobility shift assay (EMSA) verified that NF-kappaB, C/EBP, CREB and AP-1 were identified as responsible for the sulforaphane-mediated COX-2 down-regulation.	sulforaphane	129-141	prostaglandin-endoperoxide synthase 2	Mus musculus	151-156
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	prostaglandin-endoperoxide synthase 2	Mus musculus	99-104
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	175-180
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	cAMP responsive element binding protein 1	Mus musculus	182-186
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	jun proto-oncogene	Mus musculus	191-195
17996688-9	2007	Taken together, these results demonstrate that sulforaphane effectively suppressed the LPS-induced COX-2 protein via modulation of multiple core promoter elements (NF-kappaB, C/EBP, CREB and AP-1) in the COX-2 transcriptional regulation.	sulforaphane	47-59	prostaglandin-endoperoxide synthase 2	Mus musculus	204-209
17765279-6	2007	On the other hand, the activation of the Nrf2 pathway by tert-butylhydroquinone (tBHQ) and sulforaphane (SF), the known Nrf2-inducers, rendered UROtsa cells more resistant to As(III) and MMA(III).	sulforaphane	91-103	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
17765279-6	2007	On the other hand, the activation of the Nrf2 pathway by tert-butylhydroquinone (tBHQ) and sulforaphane (SF), the known Nrf2-inducers, rendered UROtsa cells more resistant to As(III) and MMA(III).	sulforaphane	91-103	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
17765279-6	2007	On the other hand, the activation of the Nrf2 pathway by tert-butylhydroquinone (tBHQ) and sulforaphane (SF), the known Nrf2-inducers, rendered UROtsa cells more resistant to As(III) and MMA(III).	sulforaphane	105-107	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
17765279-6	2007	On the other hand, the activation of the Nrf2 pathway by tert-butylhydroquinone (tBHQ) and sulforaphane (SF), the known Nrf2-inducers, rendered UROtsa cells more resistant to As(III) and MMA(III).	sulforaphane	105-107	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
17962605-8	2007	RESULTS: Sulforaphane activated Nrf2 in ICH-affected brain tissue and reduced neutrophil count, oxidative damage, and behavioral deficits caused by ICH.	sulforaphane	9-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
17914583-5	2007	SFN induced the expression of p21(WAF1/CIP1) protein causing the cell cycle arrest in a dose-dependent manner.	sulforaphane	0-3	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	30-33
17914583-5	2007	SFN induced the expression of p21(WAF1/CIP1) protein causing the cell cycle arrest in a dose-dependent manner.	sulforaphane	0-3	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	34-43
17914583-6	2007	SFN induced apoptosis which was characterized by the appearance of cells with sub-G1 DNA content and the cleavage and activation of caspase-3.	sulforaphane	0-3	caspase 3	Mus musculus	132-141
17914583-7	2007	We showed that SFN induced the growth arrest and up-regulated the expression of p21(WAF1/CIP1) protein in a p53-independent manner in human osteosarcoma MG63 cells.	sulforaphane	15-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	80-83
17914583-7	2007	We showed that SFN induced the growth arrest and up-regulated the expression of p21(WAF1/CIP1) protein in a p53-independent manner in human osteosarcoma MG63 cells.	sulforaphane	15-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	84-93
17914583-7	2007	We showed that SFN induced the growth arrest and up-regulated the expression of p21(WAF1/CIP1) protein in a p53-independent manner in human osteosarcoma MG63 cells.	sulforaphane	15-18	tumor protein p53	Homo sapiens	108-111
17914583-11	2007	Furthermore, SFN is a potent inducer of p21(WAF1/CIP1) in osteosarcoma cells.	sulforaphane	13-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	40-43
17914583-11	2007	Furthermore, SFN is a potent inducer of p21(WAF1/CIP1) in osteosarcoma cells.	sulforaphane	13-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	44-48
17914583-11	2007	Furthermore, SFN is a potent inducer of p21(WAF1/CIP1) in osteosarcoma cells.	sulforaphane	13-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	49-53
17881530-4	2007	Activation of the transcription factor NF-E2-related factor-2 (Nrf2) by sulforaphane, a naturally occurring compound present in high levels in cruciferous vegetables, significantly increased the expression of endogenous cytoprotective genes in brain tissue and microvessels as indicated by real-time PCR analysis.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	39-61
17898303-9	2007	Pretreatment with minocycline or sulforaphane for 1 hour inhibited light-induced downregulation of the NF-kappaB p65 subunit and inhibited photoreceptor apoptosis.	sulforaphane	33-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
17898303-12	2007	Minocycline and sulforaphane inhibit light-induced photoreceptor apoptosis, partly through an NF-kappaB-dependent mechanism, but not through the MAPK pathway.	sulforaphane	16-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
17555985-4	2007	SFN also inhibited the growth of prostate cancer xenografts and spontaneous intestinal polyps in mouse models, with evidence for altered histone acetylation and HDAC activities in vivo.	sulforaphane	0-3	histone deacetylase 9	Homo sapiens	161-165
17881530-4	2007	Activation of the transcription factor NF-E2-related factor-2 (Nrf2) by sulforaphane, a naturally occurring compound present in high levels in cruciferous vegetables, significantly increased the expression of endogenous cytoprotective genes in brain tissue and microvessels as indicated by real-time PCR analysis.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
17653053-12	2007	We suggested that the inhibitory effect of minocycline and sulforaphane was partly through a p38 MAPK-dependent mechanism.	sulforaphane	59-71	mitogen-activated protein kinase 14	Homo sapiens	93-96
17724334-7	2007	Nrf2 induction is brought about by treatment with sulforaphane, a natural product.	sulforaphane	50-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
17724334-8	2007	Sulforaphane thus represents an attractive option for the prevention of skin blistering associated with K14 mutations in EBS.	sulforaphane	0-12	keratin 14	Mus musculus	104-107
17664144-2	2007	The indirect antioxidant sulforaphane (SFN) protects animal tissues from chemical toxicants by increasing the expression of several families of Nrf2-regulated genes.	sulforaphane	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
17664144-2	2007	The indirect antioxidant sulforaphane (SFN) protects animal tissues from chemical toxicants by increasing the expression of several families of Nrf2-regulated genes.	sulforaphane	39-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
17664144-8	2007	Pretreatment of PSMB5-overexpressing cells with SFN did not further enhance this resistance.	sulforaphane	48-51	proteasome (prosome, macropain) subunit, beta type 5	Mus musculus	16-21
17347138-8	2007	An observed 3-fold increase in NQO1 enzymatic activity, as well as 4-fold elevated immunostaining of HO-1 in rat mammary epithelium, provides strong evidence of a pronounced pharmacodynamic action of sulforaphane.	sulforaphane	200-212	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	31-35
17347138-8	2007	An observed 3-fold increase in NQO1 enzymatic activity, as well as 4-fold elevated immunostaining of HO-1 in rat mammary epithelium, provides strong evidence of a pronounced pharmacodynamic action of sulforaphane.	sulforaphane	200-212	heme oxygenase 1	Rattus norvegicus	101-105
17300148-0	2007	Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.	sulforaphane	15-27	peroxiredoxin 5	Homo sapiens	49-70
17183064-0	2007	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	24-79
17183064-0	2007	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.	sulforaphane	0-12	mitogen-activated protein kinase 1	Homo sapiens	125-128
17183064-0	2007	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells.	sulforaphane	0-12	AKT serine/threonine kinase 1	Homo sapiens	133-136
17183064-2	2007	However, treatment with TRAIL in combination with subtoxic concentrations of sulforaphane (SFN) sensitizes TRAIL-resistant A549 cells to TRAIL-mediated apoptosis.	sulforaphane	77-89	TNF superfamily member 10	Homo sapiens	107-112
17183064-2	2007	However, treatment with TRAIL in combination with subtoxic concentrations of sulforaphane (SFN) sensitizes TRAIL-resistant A549 cells to TRAIL-mediated apoptosis.	sulforaphane	77-89	TNF superfamily member 10	Homo sapiens	107-112
17183064-2	2007	However, treatment with TRAIL in combination with subtoxic concentrations of sulforaphane (SFN) sensitizes TRAIL-resistant A549 cells to TRAIL-mediated apoptosis.	sulforaphane	91-94	TNF superfamily member 10	Homo sapiens	24-29
17183064-2	2007	However, treatment with TRAIL in combination with subtoxic concentrations of sulforaphane (SFN) sensitizes TRAIL-resistant A549 cells to TRAIL-mediated apoptosis.	sulforaphane	91-94	TNF superfamily member 10	Homo sapiens	107-112
17183064-2	2007	However, treatment with TRAIL in combination with subtoxic concentrations of sulforaphane (SFN) sensitizes TRAIL-resistant A549 cells to TRAIL-mediated apoptosis.	sulforaphane	91-94	TNF superfamily member 10	Homo sapiens	107-112
17183064-3	2007	Combined treatment with SFN and TRAIL induced chromatin condensation, DNA fragmentation, annexin V staining and sub-G(1) phase DNA content.	sulforaphane	24-27	annexin A5	Homo sapiens	89-98
17416783-4	2007	Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase A1, and heme oxygenase 1, three representative phase 2 enzymes, in mouse skin epidermis.	sulforaphane	54-66	NAD(P)H dehydrogenase, quinone 1	Mus musculus	105-137
17416783-4	2007	Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase A1, and heme oxygenase 1, three representative phase 2 enzymes, in mouse skin epidermis.	sulforaphane	54-66	NAD(P)H dehydrogenase, quinone 1	Mus musculus	139-143
17416783-4	2007	Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase A1, and heme oxygenase 1, three representative phase 2 enzymes, in mouse skin epidermis.	sulforaphane	54-66	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	146-174
17416783-4	2007	Topical application of an extract delivering 100 nmol sulforaphane/cm(2) increased the protein levels of NAD(P)H:quinone oxidoreductase 1 (NQO1), glutathione S-transferase A1, and heme oxygenase 1, three representative phase 2 enzymes, in mouse skin epidermis.	sulforaphane	54-66	heme oxygenase 1	Mus musculus	180-196
17339367-3	2007	Sulforaphane treatment inhibited cell growth, induced a G(2)-M cell cycle block, increased expression of cyclin B1, and induced oligonucleosomal DNA fragmentation in the four human breast cancer cell lines examined, MDA-MB-231, MDA-MB-468, MCF-7, and T47D cells.	sulforaphane	0-12	cyclin B1	Homo sapiens	105-114
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	Fas ligand	Homo sapiens	104-114
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	caspase 8	Homo sapiens	148-157
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	caspase 3	Homo sapiens	159-168
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	poly(ADP-ribose) polymerase 1	Homo sapiens	174-201
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	BCL2 apoptosis regulator	Homo sapiens	286-291
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	cytochrome c, somatic	Homo sapiens	315-327
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	caspase 9	Homo sapiens	360-369
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	caspase 3	Homo sapiens	374-383
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	caspase 8	Homo sapiens	393-402
17339367-4	2007	Activation of apoptosis by sulforaphane in MDA-MB-231 cells seemed to be initiated through induction of Fas ligand, which resulted in activation of caspase-8, caspase-3, and poly(ADP-ribose) polymerase, whereas apoptosis in the other breast cancer cell lines was initiated by decreased Bcl-2 expression, release of cytochrome c into the cytosol, activation of caspase-9 and caspase-3, but not caspase-8, and poly(ADP-ribose) polymerase cleavage.	sulforaphane	27-39	poly(ADP-ribose) polymerase 1	Homo sapiens	408-435
17339367-5	2007	Sulforaphane inhibited HDAC activity and decreased the expression of estrogen receptor-alpha, epidermal growth factor receptor, and human epidermal growth factor receptor-2 in each cell line, although no change in the acetylation of H3 or H4 was seen.	sulforaphane	0-12	estrogen receptor 1	Homo sapiens	69-92
17339367-5	2007	Sulforaphane inhibited HDAC activity and decreased the expression of estrogen receptor-alpha, epidermal growth factor receptor, and human epidermal growth factor receptor-2 in each cell line, although no change in the acetylation of H3 or H4 was seen.	sulforaphane	0-12	epidermal growth factor receptor	Homo sapiens	94-172
17300148-10	2007	The effects of PI3K and MAPK kinase inhibitors, LY294002, PD98059, SP600125, and SB202190, have been investigated on the sulforaphane-induced expression of thioredoxin reductase and thioredoxin.	sulforaphane	121-133	peroxiredoxin 5	Homo sapiens	156-177
17300148-10	2007	The effects of PI3K and MAPK kinase inhibitors, LY294002, PD98059, SP600125, and SB202190, have been investigated on the sulforaphane-induced expression of thioredoxin reductase and thioredoxin.	sulforaphane	121-133	thioredoxin	Homo sapiens	156-167
17300148-11	2007	PD98059 abrogates the sulforaphane-induced thioredoxin reductase at both mRNA and protein levels in HepG2 cells, although other inhibitors were found less effective.	sulforaphane	22-34	peroxiredoxin 5	Homo sapiens	43-64
17300148-14	2007	In summary, the dietary isothiocyanate, sulforaphane, is important in the regulation of thioredoxin reductase/thioredoxin redox system in cells.	sulforaphane	40-52	peroxiredoxin 5	Homo sapiens	88-109
17300148-14	2007	In summary, the dietary isothiocyanate, sulforaphane, is important in the regulation of thioredoxin reductase/thioredoxin redox system in cells.	sulforaphane	40-52	thioredoxin	Homo sapiens	88-99
17549366-6	2007	SFN-induced apoptosis was associated with the proteolytic activation of caspase-3, and the degradation/cleavage of poly (ADP-ribose) polymerase and the beta-catenin protein.	sulforaphane	0-3	caspase 3	Homo sapiens	72-81
17549366-6	2007	SFN-induced apoptosis was associated with the proteolytic activation of caspase-3, and the degradation/cleavage of poly (ADP-ribose) polymerase and the beta-catenin protein.	sulforaphane	0-3	poly(ADP-ribose) polymerase 1	Homo sapiens	115-143
17549366-7	2007	z-DEVD-fmk, a caspase-3 specific inhibitor, blocked the activation of caspase-3 and increased the survival of the SFN-treated HeLa and HepG3 cells, suggesting that caspase-3 activation is essential for SFN-induced apoptosis.	sulforaphane	114-117	caspase 3	Homo sapiens	14-23
17549366-7	2007	z-DEVD-fmk, a caspase-3 specific inhibitor, blocked the activation of caspase-3 and increased the survival of the SFN-treated HeLa and HepG3 cells, suggesting that caspase-3 activation is essential for SFN-induced apoptosis.	sulforaphane	202-205	caspase 3	Homo sapiens	70-79
17549366-7	2007	z-DEVD-fmk, a caspase-3 specific inhibitor, blocked the activation of caspase-3 and increased the survival of the SFN-treated HeLa and HepG3 cells, suggesting that caspase-3 activation is essential for SFN-induced apoptosis.	sulforaphane	202-205	caspase 3	Homo sapiens	70-79
17461789-6	2007	Identification of FMO(GS-OX1) provides a molecular tool for breeding of Brassica vegetable crops with increased levels of this important GSL, which has implications for production of functional foods enriched with the cancer-preventive sulforaphane.	sulforaphane	236-248	Flavin-binding monooxygenase family protein	Arabidopsis thaliana	18-21
17513615-0	2007	Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.	sulforaphane	42-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	13-16
17513615-1	2007	Previous studies have indicated that d,l-sulforaphane (SFN), a synthetic cancer chemopreventive analogue of cruciferous vegetable-derived isomer (-)-1-isothiocyanato-(4R)-(methylsulfinyl)-butane, activates a checkpoint kinase 2 (Chk2)-dependent G(2)-M phase cell cycle arrest in p53-deficient human prostate cancer cells.	sulforaphane	37-53	RNA exonuclease 2	Homo sapiens	55-58
17513615-1	2007	Previous studies have indicated that d,l-sulforaphane (SFN), a synthetic cancer chemopreventive analogue of cruciferous vegetable-derived isomer (-)-1-isothiocyanato-(4R)-(methylsulfinyl)-butane, activates a checkpoint kinase 2 (Chk2)-dependent G(2)-M phase cell cycle arrest in p53-deficient human prostate cancer cells.	sulforaphane	37-53	checkpoint kinase 2	Homo sapiens	208-227
17513615-1	2007	Previous studies have indicated that d,l-sulforaphane (SFN), a synthetic cancer chemopreventive analogue of cruciferous vegetable-derived isomer (-)-1-isothiocyanato-(4R)-(methylsulfinyl)-butane, activates a checkpoint kinase 2 (Chk2)-dependent G(2)-M phase cell cycle arrest in p53-deficient human prostate cancer cells.	sulforaphane	37-53	checkpoint kinase 2	Homo sapiens	229-233
17259450-4	2007	Sulforaphane (SF) is a drug identified as a potent inducer of QR1 in various non-neuronal cells.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	62-65
17259450-4	2007	Sulforaphane (SF) is a drug identified as a potent inducer of QR1 in various non-neuronal cells.	sulforaphane	14-16	NAD(P)H quinone dehydrogenase 1	Homo sapiens	62-65
17405687-11	2007	A recent study of sulforaphane pharmacokinetics suggests that lack of the GSTM1 enzyme is associated with more rapid excretion of sulforaphane.	sulforaphane	18-30	glutathione S-transferase mu 1	Homo sapiens	74-79
17405687-11	2007	A recent study of sulforaphane pharmacokinetics suggests that lack of the GSTM1 enzyme is associated with more rapid excretion of sulforaphane.	sulforaphane	130-142	glutathione S-transferase mu 1	Homo sapiens	74-79
17300148-0	2007	Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells.	sulforaphane	15-27	thioredoxin	Homo sapiens	49-60
17300148-1	2007	We have previously demonstrated that sulforaphane is a potent inducer for thioredoxin reductase in HepG2 and MCF-7 cells (Zhang et al.	sulforaphane	37-49	peroxiredoxin 5	Homo sapiens	74-95
17300148-6	2007	In this study, we have shown that sulforaphane is not only an inducer for thioredoxin reductase but also an inducer for its substrate, thioredoxin in HepG2, and undifferentiated Caco-2 cells.	sulforaphane	34-46	peroxiredoxin 5	Homo sapiens	74-95
17300148-6	2007	In this study, we have shown that sulforaphane is not only an inducer for thioredoxin reductase but also an inducer for its substrate, thioredoxin in HepG2, and undifferentiated Caco-2 cells.	sulforaphane	34-46	thioredoxin	Homo sapiens	74-85
17300148-7	2007	Sulforaphane acts at two levels in the regulation of thioredoxin reductase/thioredoxin system by the upregulation of the expression of both the enzyme and the substrate.	sulforaphane	0-12	peroxiredoxin 5	Homo sapiens	53-74
17300148-7	2007	Sulforaphane acts at two levels in the regulation of thioredoxin reductase/thioredoxin system by the upregulation of the expression of both the enzyme and the substrate.	sulforaphane	0-12	thioredoxin	Homo sapiens	53-64
17300148-8	2007	In human hepatoma HepG2 cells, sulforaphane induced thioredoxin reductase mRNA and protein by 4- and 2-fold, respectively, whereas thioredoxin mRNA was induced 2.9-fold and thioredoxin protein was unchanged in whole cell extracts, but an increase in nuclear accumulation (1.8-fold) was observed.	sulforaphane	31-43	peroxiredoxin 5	Homo sapiens	52-73
17300148-8	2007	In human hepatoma HepG2 cells, sulforaphane induced thioredoxin reductase mRNA and protein by 4- and 2-fold, respectively, whereas thioredoxin mRNA was induced 2.9-fold and thioredoxin protein was unchanged in whole cell extracts, but an increase in nuclear accumulation (1.8-fold) was observed.	sulforaphane	31-43	thioredoxin	Homo sapiens	52-63
17259330-0	2007	Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.	sulforaphane	0-12	chromobox 8	Homo sapiens	41-45
17259330-5	2007	When consumed in the diet at an average daily dose of 7.5 mumol per animal for 21 days, SFN suppressed the growth of human PC-3 prostate cancer cells by 40% in male nude mice.	sulforaphane	88-91	chromobox 8	Homo sapiens	123-127
17316439-8	2007	Bone resorption induced by SFs was inhibited by addition of OPG.	sulforaphane	27-30	TNF receptor superfamily member 11b	Homo sapiens	60-63
17150329-1	2007	OBJECTIVE: We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells.	sulforaphane	38-50	thioredoxin reductase 1	Homo sapiens	115-119
17150329-1	2007	OBJECTIVE: We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells.	sulforaphane	38-50	glutathione peroxidase 1	Homo sapiens	154-159
17150329-1	2007	OBJECTIVE: We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells.	sulforaphane	38-50	glutathione peroxidase 4	Homo sapiens	164-169
17150329-6	2007	Sulforaphane induced TR-1 expression in selenium-deficient cells (1.83 +/- 0.11 fold, P < 0.001) and selenium-supplemented cells (2.90 +/- 0.17 fold, P < 0.001) but had no inductive effect on GPX-1 or GPX-4.	sulforaphane	0-12	thioredoxin reductase 1	Homo sapiens	21-25
17150329-6	2007	Sulforaphane induced TR-1 expression in selenium-deficient cells (1.83 +/- 0.11 fold, P < 0.001) and selenium-supplemented cells (2.90 +/- 0.17 fold, P < 0.001) but had no inductive effect on GPX-1 or GPX-4.	sulforaphane	0-12	glutathione peroxidase 1	Homo sapiens	198-203
17150329-6	2007	Sulforaphane induced TR-1 expression in selenium-deficient cells (1.83 +/- 0.11 fold, P < 0.001) and selenium-supplemented cells (2.90 +/- 0.17 fold, P < 0.001) but had no inductive effect on GPX-1 or GPX-4.	sulforaphane	0-12	glutathione peroxidase 4	Homo sapiens	207-212
17150329-7	2007	The combination of selenite and sulforaphane produced an increase in TR-1 expression that was significantly greater (P < 0.001) than that achieved when each agent was added alone.	sulforaphane	32-44	thioredoxin reductase 1	Homo sapiens	69-73
17150329-10	2007	CONCLUSION: In endothelial cells, sulforaphane increases TR-1 but not GPX-1 and GPX-4 and in doing so confers protection against oxidative damage induced by lipid hydroperoxides.	sulforaphane	34-46	thioredoxin reductase 1	Homo sapiens	57-61
17150329-10	2007	CONCLUSION: In endothelial cells, sulforaphane increases TR-1 but not GPX-1 and GPX-4 and in doing so confers protection against oxidative damage induced by lipid hydroperoxides.	sulforaphane	34-46	glutathione peroxidase 1	Homo sapiens	70-75
17150329-10	2007	CONCLUSION: In endothelial cells, sulforaphane increases TR-1 but not GPX-1 and GPX-4 and in doing so confers protection against oxidative damage induced by lipid hydroperoxides.	sulforaphane	34-46	glutathione peroxidase 4	Homo sapiens	80-85
16905640-10	2007	Similarly, whereas diesel extract stimulated production of IL-8, granulocyte-macrophage colony-stimulating factor, and IL-1beta from primary human bronchial epithelial cells, sulforaphane pretreatment inhibited diesel-induced production of all of these cytokines.	sulforaphane	175-187	interleukin 1 beta	Homo sapiens	119-127
17404018-0	2007	Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation.	sulforaphane	31-43	transformation related protein 53, pseudogene	Mus musculus	116-119
17404018-8	2007	Moreover, since p53(Ser220) mutation fibroblasts showed a doxorubicin-resistant phenotype, we treated the cells with a combination of doxorubicin plus sulforaphane.	sulforaphane	151-163	transformation related protein 53, pseudogene	Mus musculus	16-19
16905640-8	2007	We verified that sulforaphane significantly augmented expression of the phase II enzyme genes GSTM1 and NQO1 and confirmed that sulforaphane treatment increased glutathione S-transferase activity in epithelial cells without inducing cell death or apoptosis.	sulforaphane	17-29	glutathione S-transferase mu 1	Homo sapiens	94-99
16905640-8	2007	We verified that sulforaphane significantly augmented expression of the phase II enzyme genes GSTM1 and NQO1 and confirmed that sulforaphane treatment increased glutathione S-transferase activity in epithelial cells without inducing cell death or apoptosis.	sulforaphane	17-29	NAD(P)H quinone dehydrogenase 1	Homo sapiens	104-108
16905640-9	2007	Sulforaphane pretreatment inhibited IL-8 production by BEAS-2B cells upon stimulation with diesel extract.	sulforaphane	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	36-40
17886065-8	2007	We have shown that the induction of phase II enzymes by the chemical sulforaphane can block DEP-induced enhanced immunoglobulin (Ig) E production in B cells and DEP-induced proinflammatory cytokine production in epithelial cells.	sulforaphane	69-81	immunoglobulin heavy constant epsilon	Homo sapiens	113-134
17849266-5	2007	Administration of sulforaphane significantly enhanced the production of IL-2 and IFN-gamma in metastatic tumor-bearing animals.	sulforaphane	18-30	interleukin 2	Mus musculus	72-76
17849266-5	2007	Administration of sulforaphane significantly enhanced the production of IL-2 and IFN-gamma in metastatic tumor-bearing animals.	sulforaphane	18-30	interferon gamma	Mus musculus	81-90
17849266-6	2007	In addition, sulforaphane significantly downregulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and GM-CSF during metastasis.	sulforaphane	13-25	interleukin 1 beta	Mus musculus	108-116
17849266-6	2007	In addition, sulforaphane significantly downregulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and GM-CSF during metastasis.	sulforaphane	13-25	interleukin 6	Mus musculus	118-122
17849266-6	2007	In addition, sulforaphane significantly downregulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and GM-CSF during metastasis.	sulforaphane	13-25	tumor necrosis factor	Mus musculus	124-133
17849266-6	2007	In addition, sulforaphane significantly downregulated the serum levels of proinflammatory cytokines such as IL-1beta, IL-6, TNF-alpha, and GM-CSF during metastasis.	sulforaphane	13-25	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	139-145
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	interleukin 2	Mus musculus	152-156
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	interferon gamma	Mus musculus	161-170
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	interleukin 1 beta	Mus musculus	220-228
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	interleukin 6	Mus musculus	230-234
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	tumor necrosis factor	Mus musculus	236-245
17849266-7	2007	These data clearly suggest that sulforaphane effectively inhibited the spread of metastatic tumor cells through the stimulation of CMI, upregulation of IL-2 and IFN-gamma, and downregulation of proinflammatory cytokines IL-1beta, IL-6, TNF-alpha, and GM-CSF.	sulforaphane	32-44	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	251-257
17237292-0	2007	Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells.	sulforaphane	30-42	AKT serine/threonine kinase 1	Homo sapiens	46-49
17028159-2	2007	SFN has been promoted as a putative chemopreventive agent to reduce cancer, and most studies have associated its anti-cancer effects with the induction of phase II xenobiotic metabolism enzymes via activation of the Keap1/Nrf2 antioxidant response pathway.	sulforaphane	0-3	kelch like ECH associated protein 1	Homo sapiens	216-221
17028159-2	2007	SFN has been promoted as a putative chemopreventive agent to reduce cancer, and most studies have associated its anti-cancer effects with the induction of phase II xenobiotic metabolism enzymes via activation of the Keap1/Nrf2 antioxidant response pathway.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	222-226
17028159-7	2007	Here, we report that SFN is a specific antagonist of human SXR and that it inhibits SXR-mediated induction of drug clearance.	sulforaphane	21-24	nuclear receptor subfamily 1 group I member 2	Homo sapiens	59-62
17028159-7	2007	Here, we report that SFN is a specific antagonist of human SXR and that it inhibits SXR-mediated induction of drug clearance.	sulforaphane	21-24	nuclear receptor subfamily 1 group I member 2	Homo sapiens	84-87
17028159-8	2007	SFN can bind directly to SXR, inhibit SXR coactivator recruitment, and efficiently repress SXR activities.	sulforaphane	0-3	nuclear receptor subfamily 1 group I member 2	Homo sapiens	25-28
17028159-8	2007	SFN can bind directly to SXR, inhibit SXR coactivator recruitment, and efficiently repress SXR activities.	sulforaphane	0-3	nuclear receptor subfamily 1 group I member 2	Homo sapiens	38-41
17028159-8	2007	SFN can bind directly to SXR, inhibit SXR coactivator recruitment, and efficiently repress SXR activities.	sulforaphane	0-3	nuclear receptor subfamily 1 group I member 2	Homo sapiens	38-41
17028159-10	2007	Thus, SFN is the first identified naturally occurring antagonist for SXR (hPXR).	sulforaphane	6-9	nuclear receptor subfamily 1 group I member 2	Homo sapiens	69-72
17028159-10	2007	Thus, SFN is the first identified naturally occurring antagonist for SXR (hPXR).	sulforaphane	6-9	nuclear receptor subfamily 1 group I member 2	Homo sapiens	74-78
17237292-9	2007	Our study is the first to report the antiproliferative effects of sulforaphane in ovarian cancer and identifying the Akt pathway as a target of sulforaphane, with implications for the inhibition of carcinogenesis by diet-based chemoprevention.	sulforaphane	144-156	AKT serine/threonine kinase 1	Homo sapiens	117-120
17237292-7	2007	Both total Akt protein and active phosphorylated levels of Akt (Ser(473)) and phosphoinositide 3-kinase were significantly decreased in sulforaphane-treated SKOV3, C3, and T3 cells with a concomitant inhibition of Akt kinase activity by sulforaphane in SKOV3 and C3 cells.	sulforaphane	136-148	AKT serine/threonine kinase 1	Homo sapiens	11-14
17237292-7	2007	Both total Akt protein and active phosphorylated levels of Akt (Ser(473)) and phosphoinositide 3-kinase were significantly decreased in sulforaphane-treated SKOV3, C3, and T3 cells with a concomitant inhibition of Akt kinase activity by sulforaphane in SKOV3 and C3 cells.	sulforaphane	136-148	AKT serine/threonine kinase 1	Homo sapiens	59-62
17237292-7	2007	Both total Akt protein and active phosphorylated levels of Akt (Ser(473)) and phosphoinositide 3-kinase were significantly decreased in sulforaphane-treated SKOV3, C3, and T3 cells with a concomitant inhibition of Akt kinase activity by sulforaphane in SKOV3 and C3 cells.	sulforaphane	136-148	AKT serine/threonine kinase 1	Homo sapiens	59-62
17237292-7	2007	Both total Akt protein and active phosphorylated levels of Akt (Ser(473)) and phosphoinositide 3-kinase were significantly decreased in sulforaphane-treated SKOV3, C3, and T3 cells with a concomitant inhibition of Akt kinase activity by sulforaphane in SKOV3 and C3 cells.	sulforaphane	237-249	AKT serine/threonine kinase 1	Homo sapiens	59-62
17237292-7	2007	Both total Akt protein and active phosphorylated levels of Akt (Ser(473)) and phosphoinositide 3-kinase were significantly decreased in sulforaphane-treated SKOV3, C3, and T3 cells with a concomitant inhibition of Akt kinase activity by sulforaphane in SKOV3 and C3 cells.	sulforaphane	237-249	AKT serine/threonine kinase 1	Homo sapiens	59-62
17237292-8	2007	This inhibitory effect of sulforaphane leads to a potent induction of apoptosis in all three cell lines, along with the cleavage of poly(ADP)ribose polymerase.	sulforaphane	26-38	poly(ADP-ribose) polymerase 1	Homo sapiens	132-158
16843502-0	2006	Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations.	sulforaphane	0-12	transformation related protein 53, pseudogene	Mus musculus	89-92
17046835-6	2006	Quinone-induced oxidative stress and the chemopreventive agent sulforaphane inhibit Keap1-dependent ubiquitination of PGAM5.	sulforaphane	63-75	kelch like ECH associated protein 1	Homo sapiens	84-89
17046835-6	2006	Quinone-induced oxidative stress and the chemopreventive agent sulforaphane inhibit Keap1-dependent ubiquitination of PGAM5.	sulforaphane	63-75	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	118-123
16516379-4	2006	The Nrf2-dependent, SFN-inducible genes were identified which include detoxification phase I, II drug metabolizing enzymes and phase III transporters.	sulforaphane	20-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8
16843502-7	2006	Sulforaphane restored chemosensitivity and induced apoptosis in doxorubicin-resistant p53(Ser220) and p53 knock-out cells, irrespective of p53 status.	sulforaphane	0-12	transformation related protein 53, pseudogene	Mus musculus	102-105
16843502-2	2006	Sulforaphane is a particularly promising chemopreventive agent, which has been shown to exert proapoptotic effects on tumor cells containing p53 mutations.	sulforaphane	0-12	transformation related protein 53, pseudogene	Mus musculus	141-144
16843502-7	2006	Sulforaphane restored chemosensitivity and induced apoptosis in doxorubicin-resistant p53(Ser220) and p53 knock-out cells, irrespective of p53 status.	sulforaphane	0-12	transformation related protein 53, pseudogene	Mus musculus	86-89
16843502-7	2006	Sulforaphane restored chemosensitivity and induced apoptosis in doxorubicin-resistant p53(Ser220) and p53 knock-out cells, irrespective of p53 status.	sulforaphane	0-12	transformation related protein 53, pseudogene	Mus musculus	102-105
16964384-4	2006	Sulforaphane (5-20 microM) induced early apoptosis and blocked cell cycle progression at G(0)/G(1) phase which was associated with upregulation of cyclin-dependent kinase inhibitor p27 expression.	sulforaphane	0-12	interferon alpha inducible protein 27	Homo sapiens	181-184
16951197-2	2006	Using human HO-1 promoter reporter plasmids and ChIP assay, we have identified that sulforaphane transcriptionally activated the upstream ARE-rich enhancer region, located at -9.0 kb upstream human HO-1 promoter.	sulforaphane	84-96	heme oxygenase 1	Homo sapiens	198-202
16571651-0	2006	Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	22-27
16571651-0	2006	Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells.	sulforaphane	0-12	TNF receptor superfamily member 10b	Homo sapiens	71-74
16571651-4	2006	In this study, we report that SFN enhances TRAIL-induced apoptosis in human osteosarcoma cells, Saos2 and MG63.	sulforaphane	30-33	TNF superfamily member 10	Homo sapiens	43-48
16571651-5	2006	The apoptosis induced by co-treatment with SFN and TRAIL was markedly blocked by a dominant negative form of the TRAIL receptor or caspase inhibitors.	sulforaphane	43-46	TNF superfamily member 10	Homo sapiens	113-118
16571651-5	2006	The apoptosis induced by co-treatment with SFN and TRAIL was markedly blocked by a dominant negative form of the TRAIL receptor or caspase inhibitors.	sulforaphane	43-46	caspase 8	Homo sapiens	131-138
16951197-0	2006	Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.	sulforaphane	23-35	mitogen-activated protein kinase 14	Homo sapiens	51-87
16951197-3	2006	Induction of HO-1 by sulforaphane was attenuated by overexpression of mutant Nrf2 plasmid in HepG2 cells and totally abolished in Nrf2 knockout mouse embryonic keratinocytes and fibroblasts.	sulforaphane	21-33	heme oxygenase 1	Homo sapiens	13-17
16951197-0	2006	Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells.	sulforaphane	23-35	heme oxygenase 1	Homo sapiens	168-184
16951197-3	2006	Induction of HO-1 by sulforaphane was attenuated by overexpression of mutant Nrf2 plasmid in HepG2 cells and totally abolished in Nrf2 knockout mouse embryonic keratinocytes and fibroblasts.	sulforaphane	21-33	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
16951197-1	2006	Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element (ARE) through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	12-24	heme oxygenase 1	Homo sapiens	50-66
16951197-1	2006	Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element (ARE) through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	12-24	heme oxygenase 1	Homo sapiens	68-72
16951197-3	2006	Induction of HO-1 by sulforaphane was attenuated by overexpression of mutant Nrf2 plasmid in HepG2 cells and totally abolished in Nrf2 knockout mouse embryonic keratinocytes and fibroblasts.	sulforaphane	21-33	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
16951197-1	2006	Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element (ARE) through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	12-24	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
16951197-4	2006	Overexpression of individual p38 mitogen-activated protein (MAP) kinase (MAPK) isoforms also suppressed constitutive as well as sulforaphane- or Nrf2-induced ARE-dependent gene expression.	sulforaphane	128-140	mitogen-activated protein kinase 14	Homo sapiens	29-32
16951197-1	2006	Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element (ARE) through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	12-24	kelch like ECH associated protein 1	Homo sapiens	179-214
16951197-1	2006	Exposure of sulforaphane to HepG2 cells increased heme oxygenase-1 (HO-1) expression by activating antioxidant response element (ARE) through induction of Nrf2 and suppression of Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	12-24	kelch like ECH associated protein 1	Homo sapiens	216-221
16951197-4	2006	Overexpression of individual p38 mitogen-activated protein (MAP) kinase (MAPK) isoforms also suppressed constitutive as well as sulforaphane- or Nrf2-induced ARE-dependent gene expression.	sulforaphane	128-140	mitogen-activated protein kinase 3	Homo sapiens	73-77
16951197-2	2006	Using human HO-1 promoter reporter plasmids and ChIP assay, we have identified that sulforaphane transcriptionally activated the upstream ARE-rich enhancer region, located at -9.0 kb upstream human HO-1 promoter.	sulforaphane	84-96	heme oxygenase 1	Homo sapiens	12-16
16951197-6	2006	Importantly, sulforaphane not only activated MAP/extracellular signal-regulated kinase (ERK) kinases 1/2 and ERK1/2, but also strongly suppressed anisomycin-induced activation of p38 MAPK isoforms by blocking phosphorylation of upstream kinases, MKK3/6.	sulforaphane	13-25	mitogen-activated protein kinase 3	Homo sapiens	109-115
16951197-6	2006	Importantly, sulforaphane not only activated MAP/extracellular signal-regulated kinase (ERK) kinases 1/2 and ERK1/2, but also strongly suppressed anisomycin-induced activation of p38 MAPK isoforms by blocking phosphorylation of upstream kinases, MKK3/6.	sulforaphane	13-25	mitogen-activated protein kinase 14	Homo sapiens	179-182
16951197-6	2006	Importantly, sulforaphane not only activated MAP/extracellular signal-regulated kinase (ERK) kinases 1/2 and ERK1/2, but also strongly suppressed anisomycin-induced activation of p38 MAPK isoforms by blocking phosphorylation of upstream kinases, MKK3/6.	sulforaphane	13-25	mitogen-activated protein kinase kinase 3	Homo sapiens	246-250
16951197-8	2006	Collectively, our results indicate that transcriptional activation of Nrf2/ARE is critical in sulforaphane-mediated induction of HO-1, which can be modulated in part by the blockade of p38 MAPK signaling pathway.	sulforaphane	94-106	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
16951197-8	2006	Collectively, our results indicate that transcriptional activation of Nrf2/ARE is critical in sulforaphane-mediated induction of HO-1, which can be modulated in part by the blockade of p38 MAPK signaling pathway.	sulforaphane	94-106	heme oxygenase 1	Homo sapiens	129-133
16951197-8	2006	Collectively, our results indicate that transcriptional activation of Nrf2/ARE is critical in sulforaphane-mediated induction of HO-1, which can be modulated in part by the blockade of p38 MAPK signaling pathway.	sulforaphane	94-106	mitogen-activated protein kinase 14	Homo sapiens	185-188
16951197-8	2006	Collectively, our results indicate that transcriptional activation of Nrf2/ARE is critical in sulforaphane-mediated induction of HO-1, which can be modulated in part by the blockade of p38 MAPK signaling pathway.	sulforaphane	94-106	mitogen-activated protein kinase 3	Homo sapiens	189-193
16912211-1	2006	Sulforaphane, a dietary isothiocyanate, possesses potent chemopreventive effects through the induction of cellular detoxifying/antioxidant enzymes via the transcription factor nuclear factor E2-related factor 2 (Nrf2).	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	212-216
16920990-8	2006	Induction of both NQO1 mRNA and protein expression could be blocked by coculture with an antioxidant and partly repressed by inhibitors of PI3K and p38 MAPK, but not by inhibitors of MAPK/ERK kinase (MEK/ERK) or protein kinase C. The ability of DEPX to enhance IgE production was blocked by the induction of phase II enzymes, including NQO1 in B cells by the chemical sulforaphane.	sulforaphane	368-380	NAD(P)H quinone dehydrogenase 1	Homo sapiens	18-22
16271437-5	2006	Sulforaphane inhibited cytokine-dependent (gamma-interferon or lipopolysaccharide) induction of iNOS in RAW 264.7 macrophages.	sulforaphane	0-12	nitric oxide synthase 2, inducible	Mus musculus	96-100
16912211-6	2006	Topical application of 100 nmol of sulforaphane once a day for 14 days prior to 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate applications decreased the incidence of skin tumor in the Nrf2(+/+) mice when compared with the vehicle-treated group.	sulforaphane	35-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	206-210
16912211-8	2006	Taken together, our results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through Nrf2.	sulforaphane	155-167	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
16912211-8	2006	Taken together, our results show for the first time that Nrf2(-/-) mice are more susceptible to skin tumorigenesis and that the chemopreventive effects of sulforaphane are mediated, at least in part, through Nrf2.	sulforaphane	155-167	nuclear factor, erythroid derived 2, like 2	Mus musculus	208-212
16500682-6	2006	Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3"-diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379.2 cell lines, suggestive of a p53-independent mechanism of apoptosis induction.	sulforaphane	15-27	poly(ADP-ribose) polymerase 1	Homo sapiens	136-140
17015256-5	2006	Sulforaphane induces via activation of the Nrf2/Keap1 system phase 2 enzymes that protect against carcinogens and oxidants.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
17015256-5	2006	Sulforaphane induces via activation of the Nrf2/Keap1 system phase 2 enzymes that protect against carcinogens and oxidants.	sulforaphane	0-12	kelch-like ECH-associated protein 1	Mus musculus	48-53
16500682-6	2006	Treatment with sulforaphane (15 microM), PEITC (10 microM), indole-3-carbinol (10 microM) and 3,3"-diindolylmethane (10 microM) induced PARP cleavage after 24 and 48 h in both 40-16 and the 379.2 cell lines, suggestive of a p53-independent mechanism of apoptosis induction.	sulforaphane	15-27	tumor protein p53	Homo sapiens	224-227
16500682-9	2006	Of note is that for sulforaphane only, ratios of pro- to anti-apoptotic Bcl-2 family protein levels directly correlated with apoptosis induction measured by PARP cleavage.	sulforaphane	20-32	BCL2 apoptosis regulator	Homo sapiens	72-77
16500682-9	2006	Of note is that for sulforaphane only, ratios of pro- to anti-apoptotic Bcl-2 family protein levels directly correlated with apoptosis induction measured by PARP cleavage.	sulforaphane	20-32	poly(ADP-ribose) polymerase 1	Homo sapiens	157-161
17569364-8	2006	The activity of SOD, bcl-2 expression and the ratio of bcl-2 and Bax were higher, while the content of MDA, the activity of MPO, apoptotic indexes, and Bax expression were lower in the SF group, HS group and FZ group than those in the I/R group.	sulforaphane	185-187	BCL2 associated X, apoptosis regulator	Rattus norvegicus	65-68
16778223-6	2006	Basal HAP3 reporter activity was significantly elevated (1.8-fold) but decreased to the same levels as HAP2 and HAP1 with increasing concentrations of sulforaphane, benzyl isothiocyanate (BITC), and epigallocatechin gallate (EGCG).	sulforaphane	151-163	nuclear transcription factor Y subunit beta	Homo sapiens	6-10
16778223-6	2006	Basal HAP3 reporter activity was significantly elevated (1.8-fold) but decreased to the same levels as HAP2 and HAP1 with increasing concentrations of sulforaphane, benzyl isothiocyanate (BITC), and epigallocatechin gallate (EGCG).	sulforaphane	151-163	huntingtin associated protein 1	Homo sapiens	103-107
16778223-6	2006	Basal HAP3 reporter activity was significantly elevated (1.8-fold) but decreased to the same levels as HAP2 and HAP1 with increasing concentrations of sulforaphane, benzyl isothiocyanate (BITC), and epigallocatechin gallate (EGCG).	sulforaphane	151-163	huntingtin associated protein 1	Homo sapiens	112-116
16740722-0	2006	Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells.	sulforaphane	0-12	cytochrome c, somatic	Homo sapiens	52-64
16740722-1	2006	The present study reports a novel response to sulforaphane, a highly promising anticancer constituent of several edible cruciferous vegetables, in PC-3 and LNCaP human prostate cancer cells involving induction of autophagy.	sulforaphane	46-58	chromobox 8	Homo sapiens	147-151
16740722-2	2006	Exposure of PC-3 and LNCaP cells to sulforaphane resulted in several specific features characteristic of autophagy, including appearance of membranous vacuoles in the cytoplasm as revealed by transmission electron microscopy and formation of acidic vesicular organelles as revealed by fluorescence microscopy following staining with the lysosomotropic agent acridine orange.	sulforaphane	36-48	chromobox 8	Homo sapiens	12-16
16740722-3	2006	The sulforaphane-induced autophagy was associated with up-regulation, processing, and recruitment to autophagosomes of microtubule-associated protein 1 light chain 3 (LC3), which is a mammalian homologue of the yeast autophagy regulating protein Apg8/Aut7p.	sulforaphane	4-16	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	167-170
16740722-3	2006	The sulforaphane-induced autophagy was associated with up-regulation, processing, and recruitment to autophagosomes of microtubule-associated protein 1 light chain 3 (LC3), which is a mammalian homologue of the yeast autophagy regulating protein Apg8/Aut7p.	sulforaphane	4-16	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	246-250
16740722-3	2006	The sulforaphane-induced autophagy was associated with up-regulation, processing, and recruitment to autophagosomes of microtubule-associated protein 1 light chain 3 (LC3), which is a mammalian homologue of the yeast autophagy regulating protein Apg8/Aut7p.	sulforaphane	4-16	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	251-256
16778223-10	2006	After culture and in vitro exposure to sulforaphane, BITC, or EGCG, the elevated GSTP1 mRNA expression of PBMCs from HAP3 individuals decreased to common expression levels.	sulforaphane	39-51	glutathione S-transferase pi 1	Homo sapiens	81-86
16778223-10	2006	After culture and in vitro exposure to sulforaphane, BITC, or EGCG, the elevated GSTP1 mRNA expression of PBMCs from HAP3 individuals decreased to common expression levels.	sulforaphane	39-51	nuclear transcription factor Y subunit beta	Homo sapiens	117-121
17569364-8	2006	The activity of SOD, bcl-2 expression and the ratio of bcl-2 and Bax were higher, while the content of MDA, the activity of MPO, apoptotic indexes, and Bax expression were lower in the SF group, HS group and FZ group than those in the I/R group.	sulforaphane	185-187	myeloperoxidase	Rattus norvegicus	124-127
17569364-8	2006	The activity of SOD, bcl-2 expression and the ratio of bcl-2 and Bax were higher, while the content of MDA, the activity of MPO, apoptotic indexes, and Bax expression were lower in the SF group, HS group and FZ group than those in the I/R group.	sulforaphane	185-187	BCL2 associated X, apoptosis regulator	Rattus norvegicus	152-155
15993536-5	2006	Separately, SF inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in TPA-induced promotion of carcinogenesis.	sulforaphane	12-14	ornithine decarboxylase, structural 1	Mus musculus	37-60
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	sulforaphane	88-100	thioredoxin	Homo sapiens	129-140
16280330-0	2006	Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells.	sulforaphane	0-12	histone deacetylase 9	Homo sapiens	22-41
16280330-2	2006	We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (HDAC).	sulforaphane	64-67	histone deacetylase 9	Homo sapiens	122-141
16280330-2	2006	We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (HDAC).	sulforaphane	64-67	histone deacetylase 9	Homo sapiens	143-147
16280330-3	2006	Here, we show that addition of 15 microM SFN also inhibited HDAC activity by 40, 30 and 40% in BPH-1, LnCaP and PC-3 prostate epithelial cells, respectively.	sulforaphane	41-44	histone deacetylase 9	Homo sapiens	60-64
16280330-4	2006	The inhibition of HDAC was accompanied by a 50-100% increase in acetylated histones in all three prostate cell lines, and in BPH-1 cells treated with SFN there was enhanced interaction of acetylated histone H4 with the promoter region of the P21 gene and the bax gene.	sulforaphane	150-153	histone deacetylase 9	Homo sapiens	18-22
16280330-4	2006	The inhibition of HDAC was accompanied by a 50-100% increase in acetylated histones in all three prostate cell lines, and in BPH-1 cells treated with SFN there was enhanced interaction of acetylated histone H4 with the promoter region of the P21 gene and the bax gene.	sulforaphane	150-153	cyclin dependent kinase inhibitor 1A	Homo sapiens	242-245
16280330-4	2006	The inhibition of HDAC was accompanied by a 50-100% increase in acetylated histones in all three prostate cell lines, and in BPH-1 cells treated with SFN there was enhanced interaction of acetylated histone H4 with the promoter region of the P21 gene and the bax gene.	sulforaphane	150-153	BCL2 associated X, apoptosis regulator	Homo sapiens	259-262
16611031-8	2006	Interestingly, three dietary chemopreventive agents, butyrate, diallyl disulfide, and sulforaphane, also have HDAC inhibitory activity.	sulforaphane	86-98	histone deacetylase 9	Homo sapiens	110-114
16536577-3	2006	Here, for the first time, we show that ESP activity is negatively correlated with the extent of formation of the health-promoting phytochemical sulforaphane in broccoli (Brassica oleracea L. ssp.	sulforaphane	144-156	epithiospecifier protein	Arabidopsis thaliana	39-42
16536577-9	2006	Genetic manipulation designed to attenuate or eliminate expression of ESP in broccoli could increase the fractional conversion of glucoraphanin to sulforaphane, enhancing potential health benefits.	sulforaphane	147-159	epithiospecifier protein	Arabidopsis thaliana	70-73
16516206-0	2006	Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
16516206-1	2006	Sulforaphane (SFN) is an activator of the transcription factor Nrf2, which plays a critical role in metabolism and excretion of xenobiotics.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
16516206-1	2006	Sulforaphane (SFN) is an activator of the transcription factor Nrf2, which plays a critical role in metabolism and excretion of xenobiotics.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
16516206-2	2006	Exposure of primary mouse hepatocytes to SFN resulted in activation of Nrf2 and significant elevation of protein expressions responsible for excretion of arsenic into extracellular space.	sulforaphane	41-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	71-75
16377050-2	2006	Sulforaphane up-regulates transcription of Phase II detoxification proteins (e.g. quinone reductase [QR]), whereas Se is needed for the production of thioredoxin reductase (TR) and glutathione peroxidase-1 (GPx1), both of which exhibit antioxidant activity.	sulforaphane	0-12	crystallin, zeta	Mus musculus	82-99
16377050-2	2006	Sulforaphane up-regulates transcription of Phase II detoxification proteins (e.g. quinone reductase [QR]), whereas Se is needed for the production of thioredoxin reductase (TR) and glutathione peroxidase-1 (GPx1), both of which exhibit antioxidant activity.	sulforaphane	0-12	glutathione peroxidase 1	Mus musculus	207-211
16539699-5	2006	RESULTS: In prostatic tissues, sulforaphane produced modest but significant increases in the enzymatic activities of NQO1, total GST and GST-mu compared to control animals.	sulforaphane	31-43	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	117-121
16539699-8	2006	Compared to control animals, sulforaphane also significantly induced NQO1 or total GST enzyme activity in the liver, kidney and, most significantly, in the bladder tissues.	sulforaphane	29-41	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	69-73
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	sulforaphane	88-100	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	142-145
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	sulforaphane	88-100	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	146-151
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	sulforaphane	88-100	nuclear factor kappa B subunit 1	Homo sapiens	179-188
16506816-1	2006	Early effects (only 1 h of exposure) of three isothiocyanates (benzyl, phenylethyl, and sulforaphane) on nuclear accumulation of thioredoxin, APE/Ref-1, and transcription factors NF-kappaB and Nrf2, as well as production of reactive oxygen species (ROS) and reduced glutathione levels were examined in human adenocarcinoma Caco-2 cells.	sulforaphane	88-100	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
16506816-3	2006	Sulforaphane was the most potent inducer of Nrf2 nuclear accumulation (10 microM, 1.9-fold) and NF-kappaB nuclear accumulation at higher concentration (25 microM, 6.3-fold).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
16272172-5	2006	Transfection with ERK2 and upstream kinase DNEE-MEK1 activated AP-1 activity, and transfection with dominant-negative mutant ERK2 (dnERK2) potently decreased AP-1 activation induced by SFN, PEITC and AITC.	sulforaphane	185-188	mitogen-activated protein kinase 1	Homo sapiens	18-22
16520658-3	2006	In this paper, we report that the NAC conjugates of four naturally occurring ITCs, including allyl ITC, benzyl ITC (BITC), phenethyl ITC and sulforaphane, potently inhibited the growth of cells derived from both low-grade superficial and high-grade invasive human bladder cancers and drug-resistant bladder cancer cells.	sulforaphane	141-153	synuclein alpha	Homo sapiens	34-37
16272172-5	2006	Transfection with ERK2 and upstream kinase DNEE-MEK1 activated AP-1 activity, and transfection with dominant-negative mutant ERK2 (dnERK2) potently decreased AP-1 activation induced by SFN, PEITC and AITC.	sulforaphane	185-188	mitogen-activated protein kinase kinase 1	Homo sapiens	48-52
16272172-5	2006	Transfection with ERK2 and upstream kinase DNEE-MEK1 activated AP-1 activity, and transfection with dominant-negative mutant ERK2 (dnERK2) potently decreased AP-1 activation induced by SFN, PEITC and AITC.	sulforaphane	185-188	mitogen-activated protein kinase 1	Homo sapiens	125-129
16272172-5	2006	Transfection with ERK2 and upstream kinase DNEE-MEK1 activated AP-1 activity, and transfection with dominant-negative mutant ERK2 (dnERK2) potently decreased AP-1 activation induced by SFN, PEITC and AITC.	sulforaphane	185-188	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-162
16272172-7	2006	Pretreatment with MEK1-ERK inhibitor U0126 and JNK inhibitor SP600125 substantially attenuated the decrease in cell viability induced by SFN, PEITC and AITC.	sulforaphane	137-140	mitogen-activated protein kinase kinase 1	Homo sapiens	18-22
16272172-7	2006	Pretreatment with MEK1-ERK inhibitor U0126 and JNK inhibitor SP600125 substantially attenuated the decrease in cell viability induced by SFN, PEITC and AITC.	sulforaphane	137-140	mitogen-activated protein kinase 1	Homo sapiens	23-26
16272172-7	2006	Pretreatment with MEK1-ERK inhibitor U0126 and JNK inhibitor SP600125 substantially attenuated the decrease in cell viability induced by SFN, PEITC and AITC.	sulforaphane	137-140	mitogen-activated protein kinase 8	Homo sapiens	47-50
16407454-0	2006	Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice.	sulforaphane	0-12	histone deacetylase 9	Homo sapiens	22-41
16407454-3	2006	In mice treated with a single oral dose of 10 mumol SFN, there was significant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer-term treatment with SFN in the diet resulted in levels of acetylated histones and p21(WAF1) in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls.	sulforaphane	52-55	histone deacetylase 9	Homo sapiens	93-97
16407454-3	2006	In mice treated with a single oral dose of 10 mumol SFN, there was significant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer-term treatment with SFN in the diet resulted in levels of acetylated histones and p21(WAF1) in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls.	sulforaphane	52-55	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	353-356
16407454-3	2006	In mice treated with a single oral dose of 10 mumol SFN, there was significant inhibition of HDAC activity in the colonic mucosa after 6 h, and immunoblots revealed a concomitant increase in acetylated histones H3 and H4, which returned to control levels by 48 h. Longer-term treatment with SFN in the diet resulted in levels of acetylated histones and p21(WAF1) in the ileum, colon, prostate, and peripheral blood mononuclear cells that were elevated compared with controls.	sulforaphane	52-55	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	357-361
16407454-5	2006	These results provide the first evidence for HDAC inhibition by SFN in vivo and imply that such a mechanism might contribute to the cancer chemoprotective and therapeutic effects of SFN, alone or in combination with other HDAC inhibitors currently undergoing clinical trials.	sulforaphane	64-67	histone deacetylase 9	Homo sapiens	45-49
16407454-5	2006	These results provide the first evidence for HDAC inhibition by SFN in vivo and imply that such a mechanism might contribute to the cancer chemoprotective and therapeutic effects of SFN, alone or in combination with other HDAC inhibitors currently undergoing clinical trials.	sulforaphane	182-185	histone deacetylase 9	Homo sapiens	45-49
16452234-0	2006	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	24-79
16382025-0	2006	The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.	sulforaphane	45-60	high mobility group box 1	Mus musculus	110-135
16382025-9	2006	Incubating RAW 264.7 cells with either oltipraz or DL-sulforaphane inhibited LPS-induced HMGB1 secretion.	sulforaphane	51-66	high mobility group box 1	Mus musculus	89-94
16382025-10	2006	Moreover, both EA and DL-sulforaphane inhibited relocalization of nuclear HMGB1 into the cytoplasm of LPS-stimulated RAW 264.7 cells.	sulforaphane	22-37	high mobility group box 1	Mus musculus	74-79
16546971-5	2006	Sulforaphane showed time- and concentration-dependent inhibitory effects on hypoxia-induced mRNA expression of vascular endothelial growth factor and two angiogenesis-associated transcription factors, hypoxia-inducible factor-1alpha and c-Myc, in a concentration range of 0.8 to 25 micromol/L.	sulforaphane	0-12	vascular endothelial growth factor A	Homo sapiens	111-145
16546971-5	2006	Sulforaphane showed time- and concentration-dependent inhibitory effects on hypoxia-induced mRNA expression of vascular endothelial growth factor and two angiogenesis-associated transcription factors, hypoxia-inducible factor-1alpha and c-Myc, in a concentration range of 0.8 to 25 micromol/L.	sulforaphane	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	201-232
16546971-5	2006	Sulforaphane showed time- and concentration-dependent inhibitory effects on hypoxia-induced mRNA expression of vascular endothelial growth factor and two angiogenesis-associated transcription factors, hypoxia-inducible factor-1alpha and c-Myc, in a concentration range of 0.8 to 25 micromol/L.	sulforaphane	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	237-242
16546971-6	2006	In addition, the expression of the vascular endothelial growth factor receptor KDR/flk-1 was inhibited by sulforaphane at the transcriptional level.	sulforaphane	106-118	vascular endothelial growth factor A	Homo sapiens	35-69
16546971-6	2006	In addition, the expression of the vascular endothelial growth factor receptor KDR/flk-1 was inhibited by sulforaphane at the transcriptional level.	sulforaphane	106-118	kinase insert domain receptor	Homo sapiens	79-82
16546971-6	2006	In addition, the expression of the vascular endothelial growth factor receptor KDR/flk-1 was inhibited by sulforaphane at the transcriptional level.	sulforaphane	106-118	kinase insert domain receptor	Homo sapiens	83-88
16520150-0	2006	Chemoprotection by sulforaphane: keep one eye beyond Keap1.	sulforaphane	19-31	kelch like ECH associated protein 1	Homo sapiens	53-58
16520150-3	2006	Considerable attention has focused on SFN as a "blocking" agent, with the ability to modulate the Nrf2/Keap1 pathway, but recent evidence suggests that SFN acts by numerous other mechanisms.	sulforaphane	38-41	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
16520150-3	2006	Considerable attention has focused on SFN as a "blocking" agent, with the ability to modulate the Nrf2/Keap1 pathway, but recent evidence suggests that SFN acts by numerous other mechanisms.	sulforaphane	38-41	kelch like ECH associated protein 1	Homo sapiens	103-108
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	100-103	cyclin dependent kinase inhibitor 1A	Homo sapiens	189-193
16452234-3	2006	Neither TNF-alpha- nor Fas-mediated apoptosis was sensitized in hepatoma cells by cotreatment with sulforaphane, suggesting that sulforaphane can selectively sensitize cells to TRAIL-induced apoptosis but not to apoptosis mediated by other death receptors.	sulforaphane	129-141	TNF superfamily member 10	Homo sapiens	177-182
16452234-4	2006	We found that sulforaphane treatment significantly up-regulated mRNA and protein levels of DR5, a death receptor of TRAIL.	sulforaphane	14-26	TNF receptor superfamily member 10b	Homo sapiens	91-94
16452234-4	2006	We found that sulforaphane treatment significantly up-regulated mRNA and protein levels of DR5, a death receptor of TRAIL.	sulforaphane	14-26	TNF superfamily member 10	Homo sapiens	116-121
16170570-0	2006	p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.	sulforaphane	77-89	tumor protein p53	Homo sapiens	0-3
16170570-0	2006	p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.	sulforaphane	77-89	cyclin dependent kinase inhibitor 1A	Homo sapiens	122-129
16170570-0	2006	p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.	sulforaphane	77-89	cyclin D1	Homo sapiens	162-171
16170570-5	2006	At high doses (>25 microM), SFN dramatically induces the expression of p21(CIP1) while significantly inhibits the expression of the G(1) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc.	sulforaphane	31-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-77
16170570-5	2006	At high doses (>25 microM), SFN dramatically induces the expression of p21(CIP1) while significantly inhibits the expression of the G(1) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc.	sulforaphane	31-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-82
16170570-5	2006	At high doses (>25 microM), SFN dramatically induces the expression of p21(CIP1) while significantly inhibits the expression of the G(1) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc.	sulforaphane	31-34	cyclin D1	Homo sapiens	182-191
16170570-5	2006	At high doses (>25 microM), SFN dramatically induces the expression of p21(CIP1) while significantly inhibits the expression of the G(1) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc.	sulforaphane	31-34	cyclin A2	Homo sapiens	193-201
16170570-5	2006	At high doses (>25 microM), SFN dramatically induces the expression of p21(CIP1) while significantly inhibits the expression of the G(1) phase cell cycle regulatory genes such as cyclin D1, cyclin A, and c-myc.	sulforaphane	31-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	207-212
16170570-7	2006	Additionally, SFN activates MAPKs pathways, including ERK, JNK and p38.	sulforaphane	14-17	mitogen-activated protein kinase 14	Homo sapiens	67-70
16452234-0	2006	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	81-86
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	34-37	synuclein alpha	Homo sapiens	65-68
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	34-37	cyclin D1	Homo sapiens	172-181
16452234-0	2006	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.	sulforaphane	0-12	TNF superfamily member 10	Homo sapiens	116-121
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	34-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	185-188
16452234-6	2006	Pretreatment with N-acetyl-l-cysteine and overexpression of catalase inhibited sulforaphane-induced up-regulation of DR5 and almost completely blocked the cotreatment-induced apoptosis.	sulforaphane	79-91	catalase	Homo sapiens	60-68
16452234-0	2006	Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.	sulforaphane	0-12	TNF receptor superfamily member 10b	Homo sapiens	198-201
16452234-6	2006	Pretreatment with N-acetyl-l-cysteine and overexpression of catalase inhibited sulforaphane-induced up-regulation of DR5 and almost completely blocked the cotreatment-induced apoptosis.	sulforaphane	79-91	TNF receptor superfamily member 10b	Homo sapiens	117-120
16452234-7	2006	Furthermore, the sulforaphane-mediated sensitization to TRAIL was efficiently reduced by administration of a blocking antibody or small interfering RNAs for DR5.	sulforaphane	17-29	TNF superfamily member 10	Homo sapiens	56-61
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	34-37	cyclin dependent kinase inhibitor 1A	Homo sapiens	189-193
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	100-103	synuclein alpha	Homo sapiens	65-68
16452234-7	2006	Furthermore, the sulforaphane-mediated sensitization to TRAIL was efficiently reduced by administration of a blocking antibody or small interfering RNAs for DR5.	sulforaphane	17-29	TNF receptor superfamily member 10b	Homo sapiens	157-160
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	100-103	cyclin D1	Homo sapiens	172-181
16452234-2	2006	Here, we show that treatment with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in combination with subtoxic doses of sulforaphane significantly induces rapid apoptosis in TRAIL-resistant hepatoma cells.	sulforaphane	142-154	TNF superfamily member 10	Homo sapiens	97-102
16170570-8	2006	Exposure of HT-29 cells with both SFN and an antioxidant, either NAC or GSH, completely blocked the SFN-mediated activation of these MAPK signaling cascades, regulation of cyclin D1and p21(CIP1) gene expression, and G(1)phase cell cycle arrest.	sulforaphane	100-103	cyclin dependent kinase inhibitor 1A	Homo sapiens	185-188
16452234-8	2006	These results collectively indicate that sulforaphane-induced generation of ROS and the subsequent up-regulation of DR5 are critical for triggering and amplifying TRAIL-induced apoptotic signaling.	sulforaphane	41-53	TNF receptor superfamily member 10b	Homo sapiens	116-119
16452234-8	2006	These results collectively indicate that sulforaphane-induced generation of ROS and the subsequent up-regulation of DR5 are critical for triggering and amplifying TRAIL-induced apoptotic signaling.	sulforaphane	41-53	TNF superfamily member 10	Homo sapiens	163-168
16452234-9	2006	We also found that sulforaphane can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and sulforaphane may be a safe strategy for treating resistant hepatomas.	sulforaphane	19-31	BCL2 like 1	Homo sapiens	51-57
16452234-9	2006	We also found that sulforaphane can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and sulforaphane may be a safe strategy for treating resistant hepatomas.	sulforaphane	19-31	BCL2 apoptosis regulator	Homo sapiens	63-68
16452234-9	2006	We also found that sulforaphane can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and sulforaphane may be a safe strategy for treating resistant hepatomas.	sulforaphane	19-31	TNF superfamily member 10	Homo sapiens	102-107
16452234-9	2006	We also found that sulforaphane can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and sulforaphane may be a safe strategy for treating resistant hepatomas.	sulforaphane	19-31	TNF superfamily member 10	Homo sapiens	175-180
16452234-9	2006	We also found that sulforaphane can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and sulforaphane may be a safe strategy for treating resistant hepatomas.	sulforaphane	185-197	BCL2 apoptosis regulator	Homo sapiens	63-68
16452234-9	2006	We also found that sulforaphane can sensitize both Bcl-xL- and Bcl-2-overexpressing hepatoma cells to TRAIL-induced apoptosis, indicating that treatment with a combination of TRAIL and sulforaphane may be a safe strategy for treating resistant hepatomas.	sulforaphane	185-197	TNF superfamily member 10	Homo sapiens	102-107
16452234-2	2006	Here, we show that treatment with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in combination with subtoxic doses of sulforaphane significantly induces rapid apoptosis in TRAIL-resistant hepatoma cells.	sulforaphane	142-154	TNF superfamily member 10	Homo sapiens	196-201
16404151-1	2005	We show that sulforaphane inhibits osteoclastogenesis in the presence of macrophage colony-stimulating factor (M-CSF) and receptor for activation of nuclear factor-kB ligand (RANKL) in osteoclast (OC) precursors.	sulforaphane	13-25	colony stimulating factor 1	Homo sapiens	73-109
16233958-3	2006	Sulforaphane (SUL), a naturally occurring isothiocyanate present in cruciferous vegetables, has been shown to induce the expression of multiple NF-E2-related factor-2 (Nrf2) responsive genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	144-166
16233958-3	2006	Sulforaphane (SUL), a naturally occurring isothiocyanate present in cruciferous vegetables, has been shown to induce the expression of multiple NF-E2-related factor-2 (Nrf2) responsive genes.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
16233958-3	2006	Sulforaphane (SUL), a naturally occurring isothiocyanate present in cruciferous vegetables, has been shown to induce the expression of multiple NF-E2-related factor-2 (Nrf2) responsive genes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	144-166
16233958-3	2006	Sulforaphane (SUL), a naturally occurring isothiocyanate present in cruciferous vegetables, has been shown to induce the expression of multiple NF-E2-related factor-2 (Nrf2) responsive genes.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
16233958-4	2006	In the present study, we demonstrate that systemically administered SUL can enter the brain as determined by increased mRNA and protein levels of the Nrf2-responsive gene heme oxygenase 1 (HO-1).	sulforaphane	68-71	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
16233958-4	2006	In the present study, we demonstrate that systemically administered SUL can enter the brain as determined by increased mRNA and protein levels of the Nrf2-responsive gene heme oxygenase 1 (HO-1).	sulforaphane	68-71	heme oxygenase 1	Homo sapiens	171-187
16997793-0	2006	Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma.	sulforaphane	99-111	interleukin 2	Mus musculus	205-209
16997793-0	2006	Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma.	sulforaphane	99-111	interferon gamma	Mus musculus	214-223
16997793-5	2006	Administration of sulforaphane significantly enhanced the production of Interleukin-2 and Interferon-gamma in normal as well as tumor-bearing animals.	sulforaphane	18-30	interleukin 2	Mus musculus	72-85
16997793-5	2006	Administration of sulforaphane significantly enhanced the production of Interleukin-2 and Interferon-gamma in normal as well as tumor-bearing animals.	sulforaphane	18-30	interferon gamma	Mus musculus	90-106
16404151-1	2005	We show that sulforaphane inhibits osteoclastogenesis in the presence of macrophage colony-stimulating factor (M-CSF) and receptor for activation of nuclear factor-kB ligand (RANKL) in osteoclast (OC) precursors.	sulforaphane	13-25	colony stimulating factor 1	Homo sapiens	111-116
16404151-1	2005	We show that sulforaphane inhibits osteoclastogenesis in the presence of macrophage colony-stimulating factor (M-CSF) and receptor for activation of nuclear factor-kB ligand (RANKL) in osteoclast (OC) precursors.	sulforaphane	13-25	TNF superfamily member 11	Homo sapiens	122-173
16404151-1	2005	We show that sulforaphane inhibits osteoclastogenesis in the presence of macrophage colony-stimulating factor (M-CSF) and receptor for activation of nuclear factor-kB ligand (RANKL) in osteoclast (OC) precursors.	sulforaphane	13-25	TNF superfamily member 11	Homo sapiens	175-180
16033772-2	2005	Treatment of the cells with sulforaphane at non-toxicity concentration (0-20 microM) resulted in coordinate increases in the induction of MT-I and MT-II mRNA, followed by corresponding increases in MT protein expression.	sulforaphane	28-40	metallothionein 2A	Homo sapiens	147-152
16332662-0	2005	Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli.	sulforaphane	60-72	glutathione S-transferase mu 1	Homo sapiens	0-28
16332662-3	2005	OBJECTIVE: We compared sulforaphane metabolism in GSTM1-null and GSTM1-positive subjects after they consumed standard broccoli and high-glucosinolate broccoli (super broccoli).	sulforaphane	23-35	glutathione S-transferase mu 1	Homo sapiens	50-55
16332662-6	2005	RESULTS: GSTM1-null subjects had slightly higher, but statistically significant, areas under the curve for sulforaphane metabolite concentrations in plasma, a greater rate of urinary excretion of sulforaphane metabolites during the first 6 h after broccoli consumption, and a higher percentage of sulforaphane excretion 24 h after ingestion than did GSTM1-positive subjects.	sulforaphane	107-119	glutathione S-transferase mu 1	Homo sapiens	9-14
16332662-6	2005	RESULTS: GSTM1-null subjects had slightly higher, but statistically significant, areas under the curve for sulforaphane metabolite concentrations in plasma, a greater rate of urinary excretion of sulforaphane metabolites during the first 6 h after broccoli consumption, and a higher percentage of sulforaphane excretion 24 h after ingestion than did GSTM1-positive subjects.	sulforaphane	196-208	glutathione S-transferase mu 1	Homo sapiens	9-14
16332662-6	2005	RESULTS: GSTM1-null subjects had slightly higher, but statistically significant, areas under the curve for sulforaphane metabolite concentrations in plasma, a greater rate of urinary excretion of sulforaphane metabolites during the first 6 h after broccoli consumption, and a higher percentage of sulforaphane excretion 24 h after ingestion than did GSTM1-positive subjects.	sulforaphane	196-208	glutathione S-transferase mu 1	Homo sapiens	9-14
16332662-8	2005	CONCLUSIONS: GSTM1 genotypes have a significant effect on the metabolism of sulforaphane derived from standard or high-glucosinolate broccoli.	sulforaphane	76-88	glutathione S-transferase mu 1	Homo sapiens	13-18
16359182-0	2005	Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane.	sulforaphane	95-107	kelch like ECH associated protein 1	Homo sapiens	44-49
16033772-3	2005	Western blot analysis revealed the increased level of the transcription factor, Nrf2 in a time-dependent manner from sulforaphane-treated cells.	sulforaphane	117-129	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
16359182-2	2005	Sulforaphane exerts cancer chemopreventive effects by inducing antioxidant/electrophile response element (ARE)-regulated phase 2 enzyme and antioxidant genes through activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which is regulated by the thiol-rich sensor protein Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	205-239
16359182-2	2005	Sulforaphane exerts cancer chemopreventive effects by inducing antioxidant/electrophile response element (ARE)-regulated phase 2 enzyme and antioxidant genes through activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which is regulated by the thiol-rich sensor protein Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	241-245
16033772-4	2005	Furthermore, sulforaphane activated the extracellular signal-regulated protein kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways.	sulforaphane	13-25	mitogen-activated protein kinase 1	Homo sapiens	40-85
16359182-2	2005	Sulforaphane exerts cancer chemopreventive effects by inducing antioxidant/electrophile response element (ARE)-regulated phase 2 enzyme and antioxidant genes through activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which is regulated by the thiol-rich sensor protein Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	300-335
16033772-4	2005	Furthermore, sulforaphane activated the extracellular signal-regulated protein kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways.	sulforaphane	13-25	mitogen-activated protein kinase 1	Homo sapiens	87-90
16359182-2	2005	Sulforaphane exerts cancer chemopreventive effects by inducing antioxidant/electrophile response element (ARE)-regulated phase 2 enzyme and antioxidant genes through activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which is regulated by the thiol-rich sensor protein Kelch-like ECH-associated protein 1 (Keap1).	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	337-342
16359182-4	2005	We hypothesized that, like other electrophilic Nrf2 activators, sulforaphane activates this system through specific modifications of the Keap1 protein.	sulforaphane	64-76	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
16033772-4	2005	Furthermore, sulforaphane activated the extracellular signal-regulated protein kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways.	sulforaphane	13-25	mitogen-activated protein kinase 1	Homo sapiens	93-96
16359182-4	2005	We hypothesized that, like other electrophilic Nrf2 activators, sulforaphane activates this system through specific modifications of the Keap1 protein.	sulforaphane	64-76	kelch like ECH associated protein 1	Homo sapiens	137-142
16033772-4	2005	Furthermore, sulforaphane activated the extracellular signal-regulated protein kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways.	sulforaphane	13-25	mitogen-activated protein kinase 8	Homo sapiens	101-124
16359182-5	2005	However, thionoacyl adducts are labile to hydrolysis and transacylation reactions, which complicate the identification of the sulforaphane adduct sites on Keap1.	sulforaphane	126-138	kelch like ECH associated protein 1	Homo sapiens	155-160
16359182-6	2005	In this study, we characterized the stability of sulforaphane thionoacyl adducts and developed a liquid chromatography-tandem mass spectrometry method to map labile sulforaphane adduct sites formed on Keap1 in vitro.	sulforaphane	165-177	kelch like ECH associated protein 1	Homo sapiens	201-206
16033772-4	2005	Furthermore, sulforaphane activated the extracellular signal-regulated protein kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways.	sulforaphane	13-25	mitogen-activated protein kinase 8	Homo sapiens	126-129
16359182-7	2005	Sulforaphane displays a distinctly different pattern of Keap1 modification than previously studied ARE inducers that modify Keap1 by alkylation.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	56-61
16033772-4	2005	Furthermore, sulforaphane activated the extracellular signal-regulated protein kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) pathways.	sulforaphane	13-25	mitogen-activated protein kinase 1	Homo sapiens	165-169
16359182-7	2005	Sulforaphane displays a distinctly different pattern of Keap1 modification than previously studied ARE inducers that modify Keap1 by alkylation.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	124-129
16359182-8	2005	Sulforaphane modified Keap1 most readily in the Kelch domain, rather than in the central linker domain, which is targeted by previously characterized ARE inducers.	sulforaphane	0-12	kelch like ECH associated protein 1	Homo sapiens	22-27
16033772-5	2005	SB203580, a specific inhibitor of p38 and PD98059, a specific inhibitor of ERK, abolished sulforaphane-induced MT protein expression, whereas SP600125, a specific inhibitor of JNK, had no significant effect.	sulforaphane	90-102	mitogen-activated protein kinase 1	Homo sapiens	34-37
16359182-13	2005	Our observations suggest a novel mechanism for Nrf2 stabilization by sulforaphane-Keap1 thionoacyl adduct formation.	sulforaphane	69-81	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
16033772-5	2005	SB203580, a specific inhibitor of p38 and PD98059, a specific inhibitor of ERK, abolished sulforaphane-induced MT protein expression, whereas SP600125, a specific inhibitor of JNK, had no significant effect.	sulforaphane	90-102	mitogen-activated protein kinase 1	Homo sapiens	75-78
16359182-13	2005	Our observations suggest a novel mechanism for Nrf2 stabilization by sulforaphane-Keap1 thionoacyl adduct formation.	sulforaphane	69-81	kelch like ECH associated protein 1	Homo sapiens	82-87
16033772-6	2005	At relatively high concentration (30-100 microM), sulforaphane is a cell growth modulator, as it induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase 3 activity, according to the appearance of the caspase 3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase in a time-dependent manner.	sulforaphane	50-62	caspase 3	Homo sapiens	210-219
16033772-6	2005	At relatively high concentration (30-100 microM), sulforaphane is a cell growth modulator, as it induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase 3 activity, according to the appearance of the caspase 3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase in a time-dependent manner.	sulforaphane	50-62	caspase 3	Homo sapiens	265-274
16033772-6	2005	At relatively high concentration (30-100 microM), sulforaphane is a cell growth modulator, as it induced apoptotic cell death characterized by internucleosomal DNA fragmentation and caused a rapid induction of caspase 3 activity, according to the appearance of the caspase 3 fragments and stimulated proteolytic cleavage of poly (ADP-ribose) polymerase in a time-dependent manner.	sulforaphane	50-62	poly(ADP-ribose) polymerase 1	Homo sapiens	324-352
16033772-7	2005	Moreover, sulforaphane-induced apoptotic cell death was accompanied by upregulation of Bax and downregulation of Bcl-2 and Bcl-X(l) protein.	sulforaphane	10-22	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
16033772-7	2005	Moreover, sulforaphane-induced apoptotic cell death was accompanied by upregulation of Bax and downregulation of Bcl-2 and Bcl-X(l) protein.	sulforaphane	10-22	BCL2 apoptosis regulator	Homo sapiens	113-118
16033772-7	2005	Moreover, sulforaphane-induced apoptotic cell death was accompanied by upregulation of Bax and downregulation of Bcl-2 and Bcl-X(l) protein.	sulforaphane	10-22	BCL2 like 1	Homo sapiens	123-131
16033772-9	2005	Taken together these results strongly suggest that at low concentrations of sulforaphane, activation of MAPKs, such as ERK and p38 pathway, lead to Nrf2-mediated MT gene expression.	sulforaphane	76-88	mitogen-activated protein kinase 1	Homo sapiens	119-122
16033772-9	2005	Taken together these results strongly suggest that at low concentrations of sulforaphane, activation of MAPKs, such as ERK and p38 pathway, lead to Nrf2-mediated MT gene expression.	sulforaphane	76-88	mitogen-activated protein kinase 1	Homo sapiens	127-130
16033772-9	2005	Taken together these results strongly suggest that at low concentrations of sulforaphane, activation of MAPKs, such as ERK and p38 pathway, lead to Nrf2-mediated MT gene expression.	sulforaphane	76-88	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
16033772-10	2005	Whereas at a higher concentration, sulforaphane is an effective apoptosis inducer in HepG(2) cells through regulation of Bcl-2 family molecular and activation of ICE/Ced-3 protease (caspase 3) cascade.	sulforaphane	35-47	BCL2 apoptosis regulator	Homo sapiens	121-126
16033772-10	2005	Whereas at a higher concentration, sulforaphane is an effective apoptosis inducer in HepG(2) cells through regulation of Bcl-2 family molecular and activation of ICE/Ced-3 protease (caspase 3) cascade.	sulforaphane	35-47	caspase 3	Homo sapiens	182-191
16356123-0	2005	Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.	sulforaphane	80-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
16211562-0	2005	Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury.	sulforaphane	0-12	aquaporin 4	Homo sapiens	22-33
16211562-5	2005	Postinjury administration of sulforaphane (SUL), an isothiocyanate present in abundance in cruciferous vegetables such as broccoli, attenuated AQP4 loss in the injury core and further increased AQP4 levels in the penumbra region compared with injured animals receiving vehicle.	sulforaphane	29-41	aquaporin 4	Homo sapiens	143-147
16211562-5	2005	Postinjury administration of sulforaphane (SUL), an isothiocyanate present in abundance in cruciferous vegetables such as broccoli, attenuated AQP4 loss in the injury core and further increased AQP4 levels in the penumbra region compared with injured animals receiving vehicle.	sulforaphane	29-41	aquaporin 4	Homo sapiens	194-198
16211562-5	2005	Postinjury administration of sulforaphane (SUL), an isothiocyanate present in abundance in cruciferous vegetables such as broccoli, attenuated AQP4 loss in the injury core and further increased AQP4 levels in the penumbra region compared with injured animals receiving vehicle.	sulforaphane	43-46	aquaporin 4	Homo sapiens	143-147
16211562-5	2005	Postinjury administration of sulforaphane (SUL), an isothiocyanate present in abundance in cruciferous vegetables such as broccoli, attenuated AQP4 loss in the injury core and further increased AQP4 levels in the penumbra region compared with injured animals receiving vehicle.	sulforaphane	43-46	aquaporin 4	Homo sapiens	194-198
16211562-7	2005	These findings suggest that the reduction of brain edema in response to SUL administration could be due, in part, to water clearance by AQP4 from the injured brain.	sulforaphane	72-75	aquaporin 4	Homo sapiens	136-140
15906351-5	2005	However, sulforaphane treatment upregulated CYP1A2 levels, determined immunologically, but the dealkylations of methoxy- and ethoxyresorufin were not similarly increased.	sulforaphane	9-21	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	44-50
15906351-9	2005	It may be inferred that sulforaphane induces hepatic CYP1A2 but the enzyme is not catalytically competent because of bound sulforaphane metabolite(s).	sulforaphane	24-36	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	53-59
16356123-1	2005	The chemopreventive agent sulforaphane (SFN) exerts anti-inflammatory activity by thiol-dependent inhibition of nuclear factor kappaB (NF-kappaB) DNA binding.	sulforaphane	26-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
16356123-1	2005	The chemopreventive agent sulforaphane (SFN) exerts anti-inflammatory activity by thiol-dependent inhibition of nuclear factor kappaB (NF-kappaB) DNA binding.	sulforaphane	40-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
15896333-0	2005	Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.	sulforaphane	51-63	AKT serine/threonine kinase 1	Homo sapiens	13-16
15993952-7	2005	DMF and SP attenuated the LPS-induced production and release of TNFalpha, IL-1beta, IL-6 and NO.	sulforaphane	8-10	tumor necrosis factor	Rattus norvegicus	64-72
15993952-7	2005	DMF and SP attenuated the LPS-induced production and release of TNFalpha, IL-1beta, IL-6 and NO.	sulforaphane	8-10	interleukin 1 beta	Rattus norvegicus	74-82
15993952-7	2005	DMF and SP attenuated the LPS-induced production and release of TNFalpha, IL-1beta, IL-6 and NO.	sulforaphane	8-10	interleukin 6	Rattus norvegicus	84-88
15993952-8	2005	In addition, DMF and SP increase both mRNA level and activity of NAD(P)H:quinone reductase (NQO-1), a detoxication enzyme, as well as the cellular glutathione content.	sulforaphane	21-23	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	92-97
16006525-4	2005	Chemical inducers such as sulforaphane are known to react with Keap1 cysteine residues, thereby promoting Nrf2 nuclear accumulation and hence ARE activation.	sulforaphane	26-38	kelch like ECH associated protein 1	Homo sapiens	63-68
16006525-4	2005	Chemical inducers such as sulforaphane are known to react with Keap1 cysteine residues, thereby promoting Nrf2 nuclear accumulation and hence ARE activation.	sulforaphane	26-38	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
15856023-0	2005	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.	sulforaphane	68-80	nuclear factor kappa B subunit 1	Homo sapiens	15-24
15856023-0	2005	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.	sulforaphane	68-80	nuclear factor kappa B subunit 1	Homo sapiens	29-38
15856023-0	2005	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.	sulforaphane	68-80	NFKB inhibitor alpha	Homo sapiens	99-111
15856023-4	2005	Treatment with SFN (20 and 30 microM) and PEITC (5 and 7.5 microM) significantly inhibited NF-kappaB transcriptional activity, nuclear transloction of p65, and gene expression of NF-kappaB-regulated VEGF, cylcin D1, and Bcl-X(L) in PC-3 C4 cells.	sulforaphane	15-18	nuclear factor kappa B subunit 1	Homo sapiens	91-100
15856023-4	2005	Treatment with SFN (20 and 30 microM) and PEITC (5 and 7.5 microM) significantly inhibited NF-kappaB transcriptional activity, nuclear transloction of p65, and gene expression of NF-kappaB-regulated VEGF, cylcin D1, and Bcl-X(L) in PC-3 C4 cells.	sulforaphane	15-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
15856023-4	2005	Treatment with SFN (20 and 30 microM) and PEITC (5 and 7.5 microM) significantly inhibited NF-kappaB transcriptional activity, nuclear transloction of p65, and gene expression of NF-kappaB-regulated VEGF, cylcin D1, and Bcl-X(L) in PC-3 C4 cells.	sulforaphane	15-18	nuclear factor kappa B subunit 1	Homo sapiens	179-188
15856023-4	2005	Treatment with SFN (20 and 30 microM) and PEITC (5 and 7.5 microM) significantly inhibited NF-kappaB transcriptional activity, nuclear transloction of p65, and gene expression of NF-kappaB-regulated VEGF, cylcin D1, and Bcl-X(L) in PC-3 C4 cells.	sulforaphane	15-18	vascular endothelial growth factor A	Homo sapiens	199-203
15856023-4	2005	Treatment with SFN (20 and 30 microM) and PEITC (5 and 7.5 microM) significantly inhibited NF-kappaB transcriptional activity, nuclear transloction of p65, and gene expression of NF-kappaB-regulated VEGF, cylcin D1, and Bcl-X(L) in PC-3 C4 cells.	sulforaphane	15-18	BCL2 like 1	Homo sapiens	220-228
15856023-9	2005	In addition, treatment with SFN and PEITC potently inhibited phosphorylation of both IKKbeta and IKKalpha and significantly inhibited the in vitro phosphorylation of IkappaBalpha mediated by IKKbeta.	sulforaphane	28-31	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	85-92
15856023-9	2005	In addition, treatment with SFN and PEITC potently inhibited phosphorylation of both IKKbeta and IKKalpha and significantly inhibited the in vitro phosphorylation of IkappaBalpha mediated by IKKbeta.	sulforaphane	28-31	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	97-105
15856023-9	2005	In addition, treatment with SFN and PEITC potently inhibited phosphorylation of both IKKbeta and IKKalpha and significantly inhibited the in vitro phosphorylation of IkappaBalpha mediated by IKKbeta.	sulforaphane	28-31	NFKB inhibitor alpha	Homo sapiens	166-178
15856023-9	2005	In addition, treatment with SFN and PEITC potently inhibited phosphorylation of both IKKbeta and IKKalpha and significantly inhibited the in vitro phosphorylation of IkappaBalpha mediated by IKKbeta.	sulforaphane	28-31	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	191-198
15896333-2	2005	In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin (ERN), have been examined on the induction of the phase II enzymes, quinine oxidoreductase (NQO1) and UDP-glucuronosyl transferase (UGT1A1), multidrug transporter (MRP2), cell cycle arrest and cell death in human colon adenocarcinoma Caco-2 cells.	sulforaphane	30-42	NAD(P)H quinone dehydrogenase 1	Homo sapiens	172-176
15896333-2	2005	In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin (ERN), have been examined on the induction of the phase II enzymes, quinine oxidoreductase (NQO1) and UDP-glucuronosyl transferase (UGT1A1), multidrug transporter (MRP2), cell cycle arrest and cell death in human colon adenocarcinoma Caco-2 cells.	sulforaphane	30-42	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	212-218
15896333-2	2005	In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin (ERN), have been examined on the induction of the phase II enzymes, quinine oxidoreductase (NQO1) and UDP-glucuronosyl transferase (UGT1A1), multidrug transporter (MRP2), cell cycle arrest and cell death in human colon adenocarcinoma Caco-2 cells.	sulforaphane	30-42	ATP binding cassette subfamily C member 2	Homo sapiens	244-248
15896333-2	2005	In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin (ERN), have been examined on the induction of the phase II enzymes, quinine oxidoreductase (NQO1) and UDP-glucuronosyl transferase (UGT1A1), multidrug transporter (MRP2), cell cycle arrest and cell death in human colon adenocarcinoma Caco-2 cells.	sulforaphane	44-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	172-176
15896333-2	2005	In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin (ERN), have been examined on the induction of the phase II enzymes, quinine oxidoreductase (NQO1) and UDP-glucuronosyl transferase (UGT1A1), multidrug transporter (MRP2), cell cycle arrest and cell death in human colon adenocarcinoma Caco-2 cells.	sulforaphane	44-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	212-218
15896333-2	2005	In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin (ERN), have been examined on the induction of the phase II enzymes, quinine oxidoreductase (NQO1) and UDP-glucuronosyl transferase (UGT1A1), multidrug transporter (MRP2), cell cycle arrest and cell death in human colon adenocarcinoma Caco-2 cells.	sulforaphane	44-47	ATP binding cassette subfamily C member 2	Homo sapiens	244-248
15896333-3	2005	Additionally, the roles of PI3K/Akt and MEK/ERK signaling pathways have been assessed in these sulforaphane- and erucin-induced events.	sulforaphane	95-107	mitogen-activated protein kinase kinase 7	Homo sapiens	40-43
15877230-7	2005	Dimethyl fumarate and sulforaphane treatment increased NQO1 activity by 1.4- to 2.8-fold and resulted in a significant enhancement of the antitumor activity of mitomycin C, but not of RH1.	sulforaphane	22-34	NAD(P)H quinone dehydrogenase 1	Homo sapiens	55-59
15998110-1	2005	Previous studies have demonstrated transcriptional induction of thioredoxin reductase (TR) by sulforaphane (SF) purified from broccoli; the mechanism of induction is via an antioxidant response element (ARE) in the promoter region of the gene.	sulforaphane	94-106	peroxiredoxin 5	Homo sapiens	64-85
15998110-1	2005	Previous studies have demonstrated transcriptional induction of thioredoxin reductase (TR) by sulforaphane (SF) purified from broccoli; the mechanism of induction is via an antioxidant response element (ARE) in the promoter region of the gene.	sulforaphane	94-106	peroxiredoxin 5	Homo sapiens	87-89
16117612-0	2005	Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.	sulforaphane	34-46	crystallin, zeta	Mus musculus	13-30
16117612-0	2005	Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells.	sulforaphane	51-63	crystallin, zeta	Mus musculus	13-30
15896333-0	2005	Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.	sulforaphane	51-63	mitogen-activated protein kinase kinase 7	Homo sapiens	21-24
15896333-3	2005	Additionally, the roles of PI3K/Akt and MEK/ERK signaling pathways have been assessed in these sulforaphane- and erucin-induced events.	sulforaphane	95-107	mitogen-activated protein kinase 1	Homo sapiens	44-47
15896333-6	2005	Both erucin and sulforaphane induced activation (phosphorylation) of ERK1/2 and Akt kinases but had no effect on JNK and p38 activation.	sulforaphane	16-28	mitogen-activated protein kinase 3	Homo sapiens	69-75
15896333-0	2005	Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells.	sulforaphane	51-63	mitogen-activated protein kinase 1	Homo sapiens	25-28
15868375-5	2005	Indeed, the caspase-3 assays and poly(ADP-ribose)polymerase (PARP) cleavage data indicated that sulforaphane stimulated caspase-3-like activity and degradation of PARP.	sulforaphane	96-108	caspase 3	Mus musculus	12-21
15896333-6	2005	Both erucin and sulforaphane induced activation (phosphorylation) of ERK1/2 and Akt kinases but had no effect on JNK and p38 activation.	sulforaphane	16-28	AKT serine/threonine kinase 1	Homo sapiens	80-83
15896333-11	2005	Taken together, these results demonstrate that PI3K/Akt and MEK/ERK signals are important intracellular mediators in erucin- and sulforaphane-mediated phase II enzyme transcription and cell cycle arrest in Caco-2 cells.	sulforaphane	129-141	AKT serine/threonine kinase 1	Homo sapiens	52-55
15896333-11	2005	Taken together, these results demonstrate that PI3K/Akt and MEK/ERK signals are important intracellular mediators in erucin- and sulforaphane-mediated phase II enzyme transcription and cell cycle arrest in Caco-2 cells.	sulforaphane	129-141	mitogen-activated protein kinase kinase 7	Homo sapiens	60-63
15896333-11	2005	Taken together, these results demonstrate that PI3K/Akt and MEK/ERK signals are important intracellular mediators in erucin- and sulforaphane-mediated phase II enzyme transcription and cell cycle arrest in Caco-2 cells.	sulforaphane	129-141	mitogen-activated protein kinase 1	Homo sapiens	64-67
15868375-5	2005	Indeed, the caspase-3 assays and poly(ADP-ribose)polymerase (PARP) cleavage data indicated that sulforaphane stimulated caspase-3-like activity and degradation of PARP.	sulforaphane	96-108	poly (ADP-ribose) polymerase family, member 1	Mus musculus	33-59
15868375-5	2005	Indeed, the caspase-3 assays and poly(ADP-ribose)polymerase (PARP) cleavage data indicated that sulforaphane stimulated caspase-3-like activity and degradation of PARP.	sulforaphane	96-108	poly (ADP-ribose) polymerase family, member 1	Mus musculus	61-65
15868375-5	2005	Indeed, the caspase-3 assays and poly(ADP-ribose)polymerase (PARP) cleavage data indicated that sulforaphane stimulated caspase-3-like activity and degradation of PARP.	sulforaphane	96-108	caspase 3	Mus musculus	120-129
15868375-5	2005	Indeed, the caspase-3 assays and poly(ADP-ribose)polymerase (PARP) cleavage data indicated that sulforaphane stimulated caspase-3-like activity and degradation of PARP.	sulforaphane	96-108	poly (ADP-ribose) polymerase family, member 1	Mus musculus	163-167
15868375-6	2005	However, cells with a wild-type or mutated p53 appeared to be more sensitive to the effects of sulforaphane than cells lacking p53.	sulforaphane	95-107	transformation related protein 53, pseudogene	Mus musculus	43-46
15868375-7	2005	Taken together, our results suggest that sulforaphane could act by a p53-independent pathway.	sulforaphane	41-53	transformation related protein 53, pseudogene	Mus musculus	69-72
15868375-8	2005	For this reason, sulforaphane can be viewed as a novel agent useful not only in the treatment of Li-Fraumeni-associated tumors but also drug resistant tumors where p53 dysregulation is a feature.	sulforaphane	17-29	transformation related protein 53, pseudogene	Mus musculus	164-167
15764812-3	2005	Exposure of PC-3 cells to growth-suppressive concentrations of SFN resulted in ROS generation, which was accompanied by disruption of mitochondrial membrane potential, cytosolic release of cytochrome c, and apoptosis.	sulforaphane	63-66	cytochrome c, somatic	Homo sapiens	189-201
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	71-83	glutathione peroxidase 2	Homo sapiens	17-23
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	71-83	kelch like ECH associated protein 1	Homo sapiens	211-216
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	71-83	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	71-83	kelch like ECH associated protein 1	Homo sapiens	229-234
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	85-88	glutathione peroxidase 2	Homo sapiens	17-23
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	85-88	kelch like ECH associated protein 1	Homo sapiens	211-216
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	85-88	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	sulforaphane	85-88	kelch like ECH associated protein 1	Homo sapiens	229-234
15923610-3	2005	The functional significance of a putative ARE in the GI-GPx promoter was validated by transcriptional activation of reporter gene constructs upon exposure to electrophiles (tBHQ, SFN, and curcumin) or overexpression of Nrf2 and by reversal of these effects by mutation of the ARE in the promoter and by overexpressed Keap1.	sulforaphane	179-182	glutathione peroxidase 2	Homo sapiens	53-59
15923610-3	2005	The functional significance of a putative ARE in the GI-GPx promoter was validated by transcriptional activation of reporter gene constructs upon exposure to electrophiles (tBHQ, SFN, and curcumin) or overexpression of Nrf2 and by reversal of these effects by mutation of the ARE in the promoter and by overexpressed Keap1.	sulforaphane	179-182	NFE2 like bZIP transcription factor 2	Homo sapiens	219-223
15923610-3	2005	The functional significance of a putative ARE in the GI-GPx promoter was validated by transcriptional activation of reporter gene constructs upon exposure to electrophiles (tBHQ, SFN, and curcumin) or overexpression of Nrf2 and by reversal of these effects by mutation of the ARE in the promoter and by overexpressed Keap1.	sulforaphane	179-182	kelch like ECH associated protein 1	Homo sapiens	317-322
15923610-5	2005	Thus, the presumed natural antioxidants sulforaphane and curcumin may exert their anti-inflammatory and anticarcinogenic effects not only by induction of phase 2 enzymes but also by the up-regulation of the selenoprotein GI-GPx.	sulforaphane	40-52	glutathione peroxidase 2	Homo sapiens	221-227
15764812-8	2005	Ectopic expression of Bcl-xL, but not Bcl-2, in PC-3 cells offered significant protection against the cell death caused by SFN.	sulforaphane	123-126	BCL2 like 1	Homo sapiens	22-28
15764812-10	2005	Furthermore, SV40-immortalized mouse embryonic fibroblasts (MEFs) derived from Bid knock-out mice displayed significant resistance toward SFN-induced apoptosis compared with wild-type MEFs.	sulforaphane	138-141	BH3 interacting domain death agonist	Mus musculus	79-82
15826493-3	2005	SUL strongly induced Nrf2 protein expression and ARE-mediated transcription activation, retarded degradation of Nrf2 through inhibiting Keap1, and thereby activating the transcriptional expression of HO-1.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
15806309-7	2005	The effect of sulforaphane (10(-6) M) in decreasing the number of wild-type cells was significantly prevented in the presence of caspase-3 inhibitor (10(-9) M), while the presence of Nomega-nitro-L-arginine methylester (NAME), an inhibitor of nitric oxide synthase, did not prevent sulforaphane-induced death of wild-type cells.	sulforaphane	14-26	caspase 3	Rattus norvegicus	129-138
15806309-7	2005	The effect of sulforaphane (10(-6) M) in decreasing the number of wild-type cells was significantly prevented in the presence of caspase-3 inhibitor (10(-9) M), while the presence of Nomega-nitro-L-arginine methylester (NAME), an inhibitor of nitric oxide synthase, did not prevent sulforaphane-induced death of wild-type cells.	sulforaphane	282-294	caspase 3	Rattus norvegicus	129-138
15806309-9	2005	This study demonstrates that sulforaphane induces cell death and apoptosis in the cloned rat hepatoma H4-II-E cells, and that overexpression of regucalcin suppresses sulforaphane-induced apoptotic cell death which is partly mediated through caspase-3..	sulforaphane	166-178	regucalcin	Rattus norvegicus	144-154
15806309-9	2005	This study demonstrates that sulforaphane induces cell death and apoptosis in the cloned rat hepatoma H4-II-E cells, and that overexpression of regucalcin suppresses sulforaphane-induced apoptotic cell death which is partly mediated through caspase-3..	sulforaphane	166-178	caspase 3	Rattus norvegicus	241-250
15949398-14	2005	CONCLUSION: (1) Low dose sulforaphane induces the expression of UGT1A, UGT1A1, UGT1A A8, and UGT1A A10 mRNA significantly.	sulforaphane	25-37	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	64-69
15949398-14	2005	CONCLUSION: (1) Low dose sulforaphane induces the expression of UGT1A, UGT1A1, UGT1A A8, and UGT1A A10 mRNA significantly.	sulforaphane	25-37	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	71-77
15949398-14	2005	CONCLUSION: (1) Low dose sulforaphane induces the expression of UGT1A, UGT1A1, UGT1A A8, and UGT1A A10 mRNA significantly.	sulforaphane	25-37	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	71-76
15949398-14	2005	CONCLUSION: (1) Low dose sulforaphane induces the expression of UGT1A, UGT1A1, UGT1A A8, and UGT1A A10 mRNA significantly.	sulforaphane	25-37	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	71-76
15949398-14	2005	CONCLUSION: (1) Low dose sulforaphane induces the expression of UGT1A, UGT1A1, UGT1A A8, and UGT1A A10 mRNA significantly.	sulforaphane	25-37	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	99-102
15756439-0	2005	Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations.	sulforaphane	55-67	BRCA1 DNA repair associated	Homo sapiens	109-114
15949398-1	2005	OBJECTIVE: To study the induction of expression of uridine 5"-diphosphate (UDP)-glucuronosyltransferase (UGT) 1A in colon cancer cells by sulforaphane (SFN) and its possible mechanism.	sulforaphane	138-150	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-112
15949398-1	2005	OBJECTIVE: To study the induction of expression of uridine 5"-diphosphate (UDP)-glucuronosyltransferase (UGT) 1A in colon cancer cells by sulforaphane (SFN) and its possible mechanism.	sulforaphane	152-155	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	105-112
15949398-8	2005	Sulforaphane of the concentration of 25 micromol/L induced the UGT1A mRNA expression time-dependently.	sulforaphane	0-12	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	63-68
15949398-9	2005	The levels of UGT1A1, UGT1A8, and UGT1A10 mRNA expression were significantly increased in the cells treated with 25 micromol/L sulforaphane compared to that in the controls (P = 0.006, P = 0.017, and P = 0.008 respectively).	sulforaphane	127-139	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	14-20
15949398-9	2005	The levels of UGT1A1, UGT1A8, and UGT1A10 mRNA expression were significantly increased in the cells treated with 25 micromol/L sulforaphane compared to that in the controls (P = 0.006, P = 0.017, and P = 0.008 respectively).	sulforaphane	127-139	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	22-28
15949398-9	2005	The levels of UGT1A1, UGT1A8, and UGT1A10 mRNA expression were significantly increased in the cells treated with 25 micromol/L sulforaphane compared to that in the controls (P = 0.006, P = 0.017, and P = 0.008 respectively).	sulforaphane	127-139	UDP glucuronosyltransferase family 1 member A10	Homo sapiens	34-41
15949398-10	2005	(2) The UGT1A protein band intensity increased significantly in the Coco-2 cells treated with sulforaphane of the concentrations 10 micromol/L approximately 30 micromol/L for 24 h in comparison with the control cells.	sulforaphane	94-106	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	8-13
15949398-13	2005	(4) Cytoplasmic labeling of NF-E2-related factor 2 (Nrf2), a transcription factor, with no nuclear staining was observed in the non-stimulated cells, whereas an intense nuclear labeling was observed in the sulforaphane-treated cells, indicating the induction of nuclear translocation of Nrf2 by sulforaphane.	sulforaphane	206-218	NFE2 like bZIP transcription factor 2	Homo sapiens	28-50
15949398-13	2005	(4) Cytoplasmic labeling of NF-E2-related factor 2 (Nrf2), a transcription factor, with no nuclear staining was observed in the non-stimulated cells, whereas an intense nuclear labeling was observed in the sulforaphane-treated cells, indicating the induction of nuclear translocation of Nrf2 by sulforaphane.	sulforaphane	206-218	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
15949398-13	2005	(4) Cytoplasmic labeling of NF-E2-related factor 2 (Nrf2), a transcription factor, with no nuclear staining was observed in the non-stimulated cells, whereas an intense nuclear labeling was observed in the sulforaphane-treated cells, indicating the induction of nuclear translocation of Nrf2 by sulforaphane.	sulforaphane	206-218	NFE2 like bZIP transcription factor 2	Homo sapiens	287-291
15949398-13	2005	(4) Cytoplasmic labeling of NF-E2-related factor 2 (Nrf2), a transcription factor, with no nuclear staining was observed in the non-stimulated cells, whereas an intense nuclear labeling was observed in the sulforaphane-treated cells, indicating the induction of nuclear translocation of Nrf2 by sulforaphane.	sulforaphane	295-307	NFE2 like bZIP transcription factor 2	Homo sapiens	28-50
15949398-13	2005	(4) Cytoplasmic labeling of NF-E2-related factor 2 (Nrf2), a transcription factor, with no nuclear staining was observed in the non-stimulated cells, whereas an intense nuclear labeling was observed in the sulforaphane-treated cells, indicating the induction of nuclear translocation of Nrf2 by sulforaphane.	sulforaphane	295-307	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
15826493-3	2005	SUL strongly induced Nrf2 protein expression and ARE-mediated transcription activation, retarded degradation of Nrf2 through inhibiting Keap1, and thereby activating the transcriptional expression of HO-1.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
15826493-3	2005	SUL strongly induced Nrf2 protein expression and ARE-mediated transcription activation, retarded degradation of Nrf2 through inhibiting Keap1, and thereby activating the transcriptional expression of HO-1.	sulforaphane	0-3	kelch like ECH associated protein 1	Homo sapiens	136-141
15826493-3	2005	SUL strongly induced Nrf2 protein expression and ARE-mediated transcription activation, retarded degradation of Nrf2 through inhibiting Keap1, and thereby activating the transcriptional expression of HO-1.	sulforaphane	0-3	heme oxygenase 1	Homo sapiens	200-204
16201852-6	2005	A peptide inhibitor of caspase-8 completely blocked SFN-induced apoptosis and that for caspase-9 exerted a major protection; however, neither inhibitor attenuated SFN-induced G2/M arrest.	sulforaphane	52-55	caspase 8	Homo sapiens	23-32
15740016-0	2005	Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells.	sulforaphane	0-12	thioredoxin reductase 1	Homo sapiens	45-68
15740016-2	2005	In this study, we have shown that three isothiocyanates, sulforaphane, erucin, and iberin, are potent inducers of thioredoxin reductase 1 (TrxR1) in human breast cancer MCF-7 cells.	sulforaphane	57-69	thioredoxin reductase 1	Homo sapiens	114-137
15740016-2	2005	In this study, we have shown that three isothiocyanates, sulforaphane, erucin, and iberin, are potent inducers of thioredoxin reductase 1 (TrxR1) in human breast cancer MCF-7 cells.	sulforaphane	57-69	thioredoxin reductase 1	Homo sapiens	139-144
15740016-3	2005	Sulforaphane, erucin, and iberin at 1 microM induce TrxR1 mRNA 2-3-fold within 8 h of treatment, and induce mRNA 5-7-fold with 12 microM ITC treatments.	sulforaphane	0-12	thioredoxin reductase 1	Homo sapiens	52-57
16201852-7	2005	Regarding potential mediators, SFN treatment induced a transient rise of reactive oxygen species (ROS) peaking within (1/2) h and the activation of JNK within 1 h but did not have any detectable effect on the phosphorylation of p38MAPK or ERK1/2 from 6 h to 24 h. Pretreatment of cells with N-acetylcysteine to enrich intracellular glutathione blocked SFN-induced ROS and apoptotic cell death.	sulforaphane	31-34	mitogen-activated protein kinase 3	Homo sapiens	239-245
15728556-0	2005	Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice.	sulforaphane	0-12	thioredoxin 1	Mus musculus	21-32
15728556-2	2005	This study was conducted to test whether sulforaphane (SF), a naturally occurring isothiocyanate that is highly concentrated in broccoli sprouts, induces Trx in retinal tissues and whether pretreatment with SF protects against light-induced retinal damage in mice.	sulforaphane	55-57	thioredoxin 1	Mus musculus	154-157
16201852-8	2005	Inhibiting the JNK activity with a pharmacologic inhibitor SP600125 abolished the induction of G2/M arrest and apoptosis by SFN, whereas chemical inhibitors for p38MAPK and MEK1/2 did not have any modulating effect on SFN-induced apoptosis.	sulforaphane	124-127	mitogen-activated protein kinase 8	Homo sapiens	15-18
16201852-8	2005	Inhibiting the JNK activity with a pharmacologic inhibitor SP600125 abolished the induction of G2/M arrest and apoptosis by SFN, whereas chemical inhibitors for p38MAPK and MEK1/2 did not have any modulating effect on SFN-induced apoptosis.	sulforaphane	218-221	mitogen-activated protein kinase 8	Homo sapiens	15-18
15572695-5	2004	Keap1-dependent ubiquitination of Nrf2 is inhibited following exposure of cells to quinone-induced oxidative stress and sulforaphane, a cancer-preventive isothiocyanate.	sulforaphane	120-132	kelch like ECH associated protein 1	Homo sapiens	0-5
15572695-5	2004	Keap1-dependent ubiquitination of Nrf2 is inhibited following exposure of cells to quinone-induced oxidative stress and sulforaphane, a cancer-preventive isothiocyanate.	sulforaphane	120-132	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	sulforaphane	203-215	kelch like ECH associated protein 1	Homo sapiens	9-14
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	sulforaphane	203-215	kelch like ECH associated protein 1	Homo sapiens	115-120
15486191-2	2004	Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)].	sulforaphane	0-12	cyclin A2	Homo sapiens	101-109
15486191-5	2004	Incubations at higher sulforaphane doses (>10 micromol/L) resulted in cleavage of caspase-3 in the G(1) subpopulation, suggesting that the induction of apoptosis and the sulforaphane-induced mitosis delay at the lower dose are independently regulated.	sulforaphane	22-34	caspase 3	Homo sapiens	85-94
15488464-4	2004	Although, the induction was lower than that observed with classic nrf-2 inducer, sulforaphane (10 microL; 7-fold), ebselen also induced expression of native NAD(P)H:quinone oxidoreductase (1.6-fold) activity; induction of this protein is known to be dependent on nrf-2 action.	sulforaphane	81-93	NFE2 like bZIP transcription factor 2	Homo sapiens	66-71
15390080-0	2004	Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism.	sulforaphane	25-37	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-64
15390080-3	2004	We have, therefore, examined the effects of two well-known inducers of phase II enzymes, sulforaphane (SF) and tert-butylhydroquinone (tBHQ), on UVB-induced AP-1 activation, with an AP-1-luciferase reporter plasmid that was stably transfected into human HaCaT keratinocytes (HCL14 cells).	sulforaphane	89-101	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-161
15390080-3	2004	We have, therefore, examined the effects of two well-known inducers of phase II enzymes, sulforaphane (SF) and tert-butylhydroquinone (tBHQ), on UVB-induced AP-1 activation, with an AP-1-luciferase reporter plasmid that was stably transfected into human HaCaT keratinocytes (HCL14 cells).	sulforaphane	89-101	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	182-186
15390080-3	2004	We have, therefore, examined the effects of two well-known inducers of phase II enzymes, sulforaphane (SF) and tert-butylhydroquinone (tBHQ), on UVB-induced AP-1 activation, with an AP-1-luciferase reporter plasmid that was stably transfected into human HaCaT keratinocytes (HCL14 cells).	sulforaphane	103-105	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	157-161
15390080-4	2004	Exposure of HCL14 cells to SF or tBHQ led to the induction of quinone reductase-1 (QR-1), a marker of global cellular phase II enzymes, as well as elevation of cellular GSH levels.	sulforaphane	27-29	NAD(P)H quinone dehydrogenase 1	Homo sapiens	62-81
15390080-4	2004	Exposure of HCL14 cells to SF or tBHQ led to the induction of quinone reductase-1 (QR-1), a marker of global cellular phase II enzymes, as well as elevation of cellular GSH levels.	sulforaphane	27-29	NAD(P)H quinone dehydrogenase 1	Homo sapiens	83-87
15486191-2	2004	Sulforaphane-treated cells accumulated in metaphase as determined by flow cytometry [4C DNA content, cyclin A(-), cyclin B1(+), and phospho-histone H3 (Ser(10))(+)].	sulforaphane	0-12	cyclin B1	Homo sapiens	114-123
15486191-4	2004	The initial detection of caspase-3 cleavage occurring in G(2)-M arrest was independent of a change in phospho-cdc2 (Tyr(15)) protein; consequently, sulforaphane treatment combined with UCN-01 had no significant impact on cellular toxicity.	sulforaphane	148-160	caspase 3	Homo sapiens	25-34
12949046-6	2003	In contrast, SFN induced phase II detoxification enzymes, UDP-glucuronosyltransferase 1A1 and glutathione S-transferase A1 mRNA expression.	sulforaphane	13-16	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	58-89
15090468-0	2004	Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.	sulforaphane	21-33	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	67-73
15090468-0	2004	Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells.	sulforaphane	21-33	glutathione S-transferase alpha 1	Homo sapiens	78-83
15090468-1	2004	The isothiocyanate, sulforaphane and the flavonoid, apigenin modulate gene expression including phase II detoxifying enzymes, such as glutathione S-transferases (GST) and UDP-glucuronosyltransferases (UGT).	sulforaphane	20-32	beta-1,3-glucuronyltransferase 2	Homo sapiens	171-199
15090468-1	2004	The isothiocyanate, sulforaphane and the flavonoid, apigenin modulate gene expression including phase II detoxifying enzymes, such as glutathione S-transferases (GST) and UDP-glucuronosyltransferases (UGT).	sulforaphane	20-32	beta-1,3-glucuronyltransferase 2	Homo sapiens	201-204
15090468-2	2004	Using undifferentiated CaCo-2 cells, we have examined the interactions between sulforaphane and apigenin in the regulation of UGT and GST expression.	sulforaphane	79-91	beta-1,3-glucuronyltransferase 2	Homo sapiens	126-129
15090468-3	2004	We show that apigenin induces UGT1A1 transcription (4-fold) but not GSTA1, and that sulforaphane induces both UGT1A1 (3.7-fold) and GSTA1 (2.8-fold) transcription in both dose- and time-dependent manners.	sulforaphane	84-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	110-116
15090468-3	2004	We show that apigenin induces UGT1A1 transcription (4-fold) but not GSTA1, and that sulforaphane induces both UGT1A1 (3.7-fold) and GSTA1 (2.8-fold) transcription in both dose- and time-dependent manners.	sulforaphane	84-96	glutathione S-transferase alpha 1	Homo sapiens	132-137
15090468-4	2004	The combination of sulforaphane and apigenin resulted in a synergistic induction of UGT1A1 mRNA up to 12-fold, although this interaction was not seen for GSTA1.	sulforaphane	19-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-90
15090468-5	2004	Nuclear factor kappa B (NF-kappaB) mRNA was induced by apigenin and sulforaphane (2.5- and 2-fold, respectively).	sulforaphane	68-80	nuclear factor kappa B subunit 1	Homo sapiens	0-22
15090468-5	2004	Nuclear factor kappa B (NF-kappaB) mRNA was induced by apigenin and sulforaphane (2.5- and 2-fold, respectively).	sulforaphane	68-80	nuclear factor kappa B subunit 1	Homo sapiens	24-33
15090468-6	2004	NF-kappaB translocation inhibitor SN50 and phosphatidylinositol 3-kinase (PI3) inhibitor LY294002 decreased the induction of GSTA1 by sulforaphane almost to baseline level.	sulforaphane	134-146	nuclear factor kappa B subunit 1	Homo sapiens	0-9
15090468-6	2004	NF-kappaB translocation inhibitor SN50 and phosphatidylinositol 3-kinase (PI3) inhibitor LY294002 decreased the induction of GSTA1 by sulforaphane almost to baseline level.	sulforaphane	134-146	glutathione S-transferase alpha 1	Homo sapiens	125-130
15090468-7	2004	However, the MEK inhibitor PD98059 enhanced significantly the induction of GSTA1 by sulforaphane.	sulforaphane	84-96	mitogen-activated protein kinase kinase 7	Homo sapiens	13-16
15090468-7	2004	However, the MEK inhibitor PD98059 enhanced significantly the induction of GSTA1 by sulforaphane.	sulforaphane	84-96	glutathione S-transferase alpha 1	Homo sapiens	75-80
15090468-9	2004	Conversely, the induction of UGT1A1 transcription by sulforaphane was totally abolished by PD98059, although PD98059 slightly enhanced (20%) the induction of UGT1A1 by apigenin implying that the induction of UGT1A1 by sulforaphane is mediated by MAPK/extracellular signal-regulated kinase kinase, whereas UGT1A1 induction by apigenin may be associated with NF-kappaB translocation since the NF-kappaB translocation inhibitor, SN50 enhanced the induction of UGT by apigenin.	sulforaphane	53-65	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
15090468-9	2004	Conversely, the induction of UGT1A1 transcription by sulforaphane was totally abolished by PD98059, although PD98059 slightly enhanced (20%) the induction of UGT1A1 by apigenin implying that the induction of UGT1A1 by sulforaphane is mediated by MAPK/extracellular signal-regulated kinase kinase, whereas UGT1A1 induction by apigenin may be associated with NF-kappaB translocation since the NF-kappaB translocation inhibitor, SN50 enhanced the induction of UGT by apigenin.	sulforaphane	53-65	beta-1,3-glucuronyltransferase 2	Homo sapiens	29-32
15090468-9	2004	Conversely, the induction of UGT1A1 transcription by sulforaphane was totally abolished by PD98059, although PD98059 slightly enhanced (20%) the induction of UGT1A1 by apigenin implying that the induction of UGT1A1 by sulforaphane is mediated by MAPK/extracellular signal-regulated kinase kinase, whereas UGT1A1 induction by apigenin may be associated with NF-kappaB translocation since the NF-kappaB translocation inhibitor, SN50 enhanced the induction of UGT by apigenin.	sulforaphane	218-230	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	29-35
15337839-5	2004	The IC50 values for DNM and VBL in MCF-7/Adr cells were 7.12 +/- 0.42 microM and 0.106 +/- 0.004 microM (mean +/- SE) following a 48-hr exposure; IC50 values for BITC, PEITC, NITC, and sulforaphane were 5.95 +/- 0.10, 7.32 +/- 0.25, 77.9 +/- 8.03, and 13.7 +/- 0.82 microM, respectively, with similar values obtained in MCF-7/wt cells.	sulforaphane	185-197	dynamin 1	Homo sapiens	20-31
15313918-0	2004	A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.	sulforaphane	40-52	histone deacetylase 9	Homo sapiens	68-87
15313918-3	2004	We tested the hypothesis that SFN acts as an inhibitor of histone deacetylase (HDAC).	sulforaphane	30-33	histone deacetylase 9	Homo sapiens	58-77
15313918-3	2004	We tested the hypothesis that SFN acts as an inhibitor of histone deacetylase (HDAC).	sulforaphane	30-33	histone deacetylase 9	Homo sapiens	79-83
15313918-4	2004	In human embryonic kidney 293 cells, SFN dose-dependently increased the activity of a beta-catenin-responsive reporter (TOPflash), without altering beta-catenin or HDAC protein levels.	sulforaphane	37-40	catenin beta 1	Homo sapiens	86-98
15313918-8	2004	Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter.	sulforaphane	95-98	histone deacetylase 9	Homo sapiens	167-171
15313918-8	2004	Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter.	sulforaphane	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	234-237
15313918-8	2004	Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter.	sulforaphane	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	238-242
15313918-8	2004	Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter.	sulforaphane	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	243-247
15313918-8	2004	Finally, several of these findings were recapitulated in HCT116 human colorectal cancer cells: SFN dose-dependently increased TOPflash reporter activity and inhibited HDAC activity, there was an increase in acetylated histones and in p21(Cip1/Waf1), and chromatin immunoprecipitation assays revealed an increase in acetylated histones bound to the P21 promoter.	sulforaphane	95-98	cyclin dependent kinase inhibitor 1A	Homo sapiens	348-351
15672752-11	2004	NQO1 expression responded to PEITC (11 x at 25 microM), DIM (4.5 x at 50 microM) and SFN (5 x at 10 microM) treatments.	sulforaphane	85-88	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-4
15073169-9	2004	These findings indicate that Chk2-mediated phosphorylation of Cdc25C plays a major role in irreversible G(2)/M arrest by SFN.	sulforaphane	121-124	cell division cycle 25C	Homo sapiens	62-68
15184012-9	2004	The induction of QR in cultured mouse hepatoma Hepa lclc7 cells paralleled increases in sulforaphane formation.	sulforaphane	88-100	crystallin, zeta	Mus musculus	17-19
14578157-4	2004	Treatment of asynchronous F3II cells with 15 microM SUL resulted in G2/M cell cycle arrest, elevated p34cdc2 (cdc2) kinase activity, Bcl-2 down-regulation, evidence of caspase activation, and aggregation of condensed nuclear chromatin.	sulforaphane	52-55	cyclin-dependent kinase 1	Mus musculus	101-108
14578157-4	2004	Treatment of asynchronous F3II cells with 15 microM SUL resulted in G2/M cell cycle arrest, elevated p34cdc2 (cdc2) kinase activity, Bcl-2 down-regulation, evidence of caspase activation, and aggregation of condensed nuclear chromatin.	sulforaphane	52-55	cyclin-dependent kinase 1	Mus musculus	104-108
14578157-4	2004	Treatment of asynchronous F3II cells with 15 microM SUL resulted in G2/M cell cycle arrest, elevated p34cdc2 (cdc2) kinase activity, Bcl-2 down-regulation, evidence of caspase activation, and aggregation of condensed nuclear chromatin.	sulforaphane	52-55	B cell leukemia/lymphoma 2	Mus musculus	133-138
14578157-9	2004	Western blot analysis of tumor proteins demonstrated significantly (P<0.05) reduced PCNA and elevated PARP fragmentation in samples from animals dosed with SUL.	sulforaphane	159-162	proliferating cell nuclear antigen	Mus musculus	87-91
14578157-9	2004	Western blot analysis of tumor proteins demonstrated significantly (P<0.05) reduced PCNA and elevated PARP fragmentation in samples from animals dosed with SUL.	sulforaphane	159-162	poly (ADP-ribose) polymerase family, member 1	Mus musculus	105-109
14670615-5	2004	Both the cytotoxic effect and apoptotic characteristics induced by sulforaphane were reversed by zVAD-fmk, a broad spectrum caspase inhibitor, demonstrating the important role of caspases in its cytotoxic effect.	sulforaphane	67-79	caspase 9	Homo sapiens	179-187
14514658-4	2004	SFN-induced apoptosis, and cleavage of procaspase-3 and PARP were blocked upon pre-treatment of cells with pan caspase inhibitor z-VADfmk, and specific inhibitors of caspase-9 (z-LEHDfmk) and caspase-8 (z-IETDfmk) suggesting involvement of both caspase-9 and caspase-8 pathways in SFN-induced cell death.	sulforaphane	0-3	caspase 9	Homo sapiens	166-175
14514658-4	2004	SFN-induced apoptosis, and cleavage of procaspase-3 and PARP were blocked upon pre-treatment of cells with pan caspase inhibitor z-VADfmk, and specific inhibitors of caspase-9 (z-LEHDfmk) and caspase-8 (z-IETDfmk) suggesting involvement of both caspase-9 and caspase-8 pathways in SFN-induced cell death.	sulforaphane	0-3	caspase 8	Homo sapiens	192-201
14514658-4	2004	SFN-induced apoptosis, and cleavage of procaspase-3 and PARP were blocked upon pre-treatment of cells with pan caspase inhibitor z-VADfmk, and specific inhibitors of caspase-9 (z-LEHDfmk) and caspase-8 (z-IETDfmk) suggesting involvement of both caspase-9 and caspase-8 pathways in SFN-induced cell death.	sulforaphane	0-3	caspase 9	Homo sapiens	245-254
14514658-4	2004	SFN-induced apoptosis, and cleavage of procaspase-3 and PARP were blocked upon pre-treatment of cells with pan caspase inhibitor z-VADfmk, and specific inhibitors of caspase-9 (z-LEHDfmk) and caspase-8 (z-IETDfmk) suggesting involvement of both caspase-9 and caspase-8 pathways in SFN-induced cell death.	sulforaphane	0-3	caspase 8	Homo sapiens	259-268
14514658-4	2004	SFN-induced apoptosis, and cleavage of procaspase-3 and PARP were blocked upon pre-treatment of cells with pan caspase inhibitor z-VADfmk, and specific inhibitors of caspase-9 (z-LEHDfmk) and caspase-8 (z-IETDfmk) suggesting involvement of both caspase-9 and caspase-8 pathways in SFN-induced cell death.	sulforaphane	281-284	caspase 3	Homo sapiens	39-51
14654956-7	2004	SFN induced signals that inhibited the activity of cyclin-dependent kinase cdk4 with an up-stream induction of cdk inhibitor p21WAF-1/Cip-1, and reduced cyclin D1.	sulforaphane	0-3	cyclin dependent kinase 4	Homo sapiens	75-79
14654956-7	2004	SFN induced signals that inhibited the activity of cyclin-dependent kinase cdk4 with an up-stream induction of cdk inhibitor p21WAF-1/Cip-1, and reduced cyclin D1.	sulforaphane	0-3	cyclin dependent kinase inhibitor 1A	Homo sapiens	125-139
14654956-7	2004	SFN induced signals that inhibited the activity of cyclin-dependent kinase cdk4 with an up-stream induction of cdk inhibitor p21WAF-1/Cip-1, and reduced cyclin D1.	sulforaphane	0-3	cyclin D1	Homo sapiens	153-162
15623468-1	2004	Cruciferous vegetables contain anticarcinogenic isothiocyanates (ITCs), particularly the potent sulforaphane, which may decrease risk of prostate cancer through induction of phase II enzymes, including glutathione S-transferases (GSTs).	sulforaphane	96-108	glutathione S-transferase mu 1	Homo sapiens	230-234
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	56-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	56-68	glutathione S-transferase alpha 1	Homo sapiens	33-38
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	56-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	171-177
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	56-68	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	171-177
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	195-207	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	22-28
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	195-207	glutathione S-transferase alpha 1	Homo sapiens	33-38
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	195-207	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	171-177
15090468-10	2004	The results show that UGT1A1 and GSTA1 are regulated by sulforaphane through different signal transduction pathways and the differences in the mechanisms of modulation of UGT1A1 transcription by sulforaphane and apigenin resulted in a synergistic effect between these two compounds in the induction of UGT1A1.	sulforaphane	195-207	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	171-177
15073169-0	2004	Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.	sulforaphane	0-12	checkpoint kinase 2	Homo sapiens	59-78
15073169-1	2004	Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer cells by causing caspase-9- and caspase-8-mediated apoptosis.	sulforaphane	27-39	caspase 9	Homo sapiens	181-190
15073169-1	2004	Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer cells by causing caspase-9- and caspase-8-mediated apoptosis.	sulforaphane	27-39	caspase 8	Homo sapiens	196-205
15073169-1	2004	Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer cells by causing caspase-9- and caspase-8-mediated apoptosis.	sulforaphane	41-44	caspase 9	Homo sapiens	181-190
15073169-1	2004	Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer cells by causing caspase-9- and caspase-8-mediated apoptosis.	sulforaphane	41-44	caspase 8	Homo sapiens	196-205
15073169-3	2004	Cell cycle arrest induced by SFN was associated with a significant decrease in protein levels of cyclin B1, cell division cycle (Cdc) 25B, and Cdc25C, leading to accumulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.	sulforaphane	29-32	cyclin B1	Homo sapiens	97-106
15073169-3	2004	Cell cycle arrest induced by SFN was associated with a significant decrease in protein levels of cyclin B1, cell division cycle (Cdc) 25B, and Cdc25C, leading to accumulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.	sulforaphane	29-32	cell division cycle 25B	Homo sapiens	129-137
15073169-3	2004	Cell cycle arrest induced by SFN was associated with a significant decrease in protein levels of cyclin B1, cell division cycle (Cdc) 25B, and Cdc25C, leading to accumulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.	sulforaphane	29-32	cell division cycle 25C	Homo sapiens	143-149
15073169-3	2004	Cell cycle arrest induced by SFN was associated with a significant decrease in protein levels of cyclin B1, cell division cycle (Cdc) 25B, and Cdc25C, leading to accumulation of Tyr-15-phosphorylated (inactive) cyclin-dependent kinase 1.	sulforaphane	29-32	cyclin dependent kinase 1	Homo sapiens	211-236
15073169-5	2004	Interestingly, SFN treatment also resulted in a rapid and sustained phosphorylation of Cdc25C at Ser-216, leading to its translocation from the nucleus to the cytoplasm because of increased binding with 14-3-3beta.	sulforaphane	15-18	cell division cycle 25C	Homo sapiens	87-93
15073169-7	2004	Transient transfection of PC-3 cells with Chk2-specific small interfering RNA duplexes significantly attenuated SFN-induced G(2)/M arrest.	sulforaphane	112-115	checkpoint kinase 2	Homo sapiens	42-46
15073169-8	2004	HCT116 human colon cancer-derived Chk2(-/-) cells were significantly more resistant to G(2)/M arrest by SFN compared with the wild type HCT116 cells.	sulforaphane	104-107	checkpoint kinase 2	Homo sapiens	34-38
15073169-9	2004	These findings indicate that Chk2-mediated phosphorylation of Cdc25C plays a major role in irreversible G(2)/M arrest by SFN.	sulforaphane	121-124	checkpoint kinase 2	Homo sapiens	29-33
15139522-8	2004	Phenethyl isothiocyanate, sulforaphane, curcumin, and resveratrol increased AP-1-luciferase activity dose-dependently and then decreased at higher doses in the presence or absence of TPA.	sulforaphane	26-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-80
14514658-2	2004	Here, we report that SFN inhibited proliferation of cultured PC-3 human prostate cancer cells by inducing apoptosis that was characterized by appearance of cells with sub-G0/G1 DNA content, formation of cytoplasmic histone associated DNA fragments and cleavage of poly(ADP-ribose)polymerase (PARP).	sulforaphane	21-24	poly(ADP-ribose) polymerase 1	Homo sapiens	264-290
14514658-2	2004	Here, we report that SFN inhibited proliferation of cultured PC-3 human prostate cancer cells by inducing apoptosis that was characterized by appearance of cells with sub-G0/G1 DNA content, formation of cytoplasmic histone associated DNA fragments and cleavage of poly(ADP-ribose)polymerase (PARP).	sulforaphane	21-24	poly(ADP-ribose) polymerase 1	Homo sapiens	292-296
14514658-3	2004	SFN-induced apoptosis was associated with up-regulation of Bax, down-regulation of Bcl-2 and activation of caspases-3, -9 and -8.	sulforaphane	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
14514658-3	2004	SFN-induced apoptosis was associated with up-regulation of Bax, down-regulation of Bcl-2 and activation of caspases-3, -9 and -8.	sulforaphane	0-3	BCL2 apoptosis regulator	Homo sapiens	83-88
14514658-3	2004	SFN-induced apoptosis was associated with up-regulation of Bax, down-regulation of Bcl-2 and activation of caspases-3, -9 and -8.	sulforaphane	0-3	caspase 3	Homo sapiens	107-128
15231455-4	2004	In previously published data, a significant increase in the G2/M phase of the cell cycle has been observed in SFN-treated cells that was associated with increased cyclin B1 protein levels.	sulforaphane	110-113	cyclin B1	Homo sapiens	163-172
15231455-5	2004	In the present study, our results show that SFN induced p21 expression.	sulforaphane	44-47	cyclin dependent kinase inhibitor 1A	Homo sapiens	56-59
15231455-6	2004	Moreover, preincubation of HT29 cells with roscovitine, a specific cdc2 kinase inhibitor, blocked the G2/M phase accumulation of HT29 cells treated with SFN and abolished its apoptotic effect (22.2 +/- 4 of floating cells in SFN-treated cells vs. 6.55 +/- 2 in cells treated with both SFN and roscovitine).	sulforaphane	153-156	cyclin dependent kinase 1	Homo sapiens	67-71
12949046-6	2003	In contrast, SFN induced phase II detoxification enzymes, UDP-glucuronosyltransferase 1A1 and glutathione S-transferase A1 mRNA expression.	sulforaphane	13-16	glutathione S-transferase alpha 1	Homo sapiens	94-122
14612554-8	2003	The decrease in ARE expression at higher concentrations of SFN and SFN-NAC was correlated with accelerated apoptotic cell death, with a dose-dependent activation of caspase 3 activity by SFN.	sulforaphane	59-62	caspase 3	Homo sapiens	165-174
15033759-7	2003	We demonstrated that sulforaphane arrested cell-cycle progression in G1 phase by a significant down-modulation of cyclin D3.	sulforaphane	21-33	cyclin D3	Homo sapiens	114-123
15033759-8	2003	Moreover, sulforaphane induced apoptosis (and also necrosis), mediated by an increase in the expression of p53, whereas it exerted little effect on bcl-2 and bax levels.	sulforaphane	10-22	tumor protein p53	Homo sapiens	107-110
14612554-1	2003	Sulforaphane (SFN) and its N-acetyl-L-cysteine (NAC) conjugate are effective inhibitors of tumorigenesis in animal models.	sulforaphane	0-12	X-linked Kx blood group	Homo sapiens	48-51
14612554-1	2003	Sulforaphane (SFN) and its N-acetyl-L-cysteine (NAC) conjugate are effective inhibitors of tumorigenesis in animal models.	sulforaphane	14-17	X-linked Kx blood group	Homo sapiens	48-51
14612554-8	2003	The decrease in ARE expression at higher concentrations of SFN and SFN-NAC was correlated with accelerated apoptotic cell death, with a dose-dependent activation of caspase 3 activity by SFN.	sulforaphane	67-70	X-linked Kx blood group	Homo sapiens	71-74
14612554-8	2003	The decrease in ARE expression at higher concentrations of SFN and SFN-NAC was correlated with accelerated apoptotic cell death, with a dose-dependent activation of caspase 3 activity by SFN.	sulforaphane	67-70	caspase 3	Homo sapiens	165-174
14612554-11	2003	Taken together, these results suggest that the biological effects of SFN and SFN-NAC on the induction of ARE-related gene expression and apoptosis could be different from each other; however, the different effects on ARE-related gene expression and apoptosis elicited by SFN can be blocked by the addition of GSH.	sulforaphane	77-80	X-linked Kx blood group	Homo sapiens	81-84
14573750-6	2003	Expression of mGSTA3 in Hepa1c1c7 mouse hepatoma cells was found to be inducible by sulforaphane, an organic isothiocyanate that can transcriptionally activate genes through the antioxidant response element (ARE).	sulforaphane	84-96	glutathione S-transferase, alpha 3	Mus musculus	14-20
14573750-7	2003	Sulforaphane also induced transcription of a luciferase reporter containing a 1.5 kb fragment of the mGSTA3 5"-upstream region.	sulforaphane	0-12	glutathione S-transferase, alpha 3	Mus musculus	101-107
12816537-5	2003	Examination of wild-type and nrf2 (-/-) mouse embryonic fibroblasts demonstrated that Nrf2 is essential for both constitutive expression of NQO1 and its induction by sulphoraphane.	sulforaphane	166-179	nuclear factor, erythroid derived 2, like 2	Mus musculus	29-33
14585973-7	2003	Both sulforaphane, a chemopreventive isothiocyanate, and oxidative stress enable Nrf2 to escape Keap1-dependent degradation, leading to stabilization of Nrf2, increased nuclear localization of Nrf2, and activation of Nrf2-dependent cancer-protective genes.	sulforaphane	5-17	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
14585973-7	2003	Both sulforaphane, a chemopreventive isothiocyanate, and oxidative stress enable Nrf2 to escape Keap1-dependent degradation, leading to stabilization of Nrf2, increased nuclear localization of Nrf2, and activation of Nrf2-dependent cancer-protective genes.	sulforaphane	5-17	kelch like ECH associated protein 1	Homo sapiens	96-101
14585973-7	2003	Both sulforaphane, a chemopreventive isothiocyanate, and oxidative stress enable Nrf2 to escape Keap1-dependent degradation, leading to stabilization of Nrf2, increased nuclear localization of Nrf2, and activation of Nrf2-dependent cancer-protective genes.	sulforaphane	5-17	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
14585973-7	2003	Both sulforaphane, a chemopreventive isothiocyanate, and oxidative stress enable Nrf2 to escape Keap1-dependent degradation, leading to stabilization of Nrf2, increased nuclear localization of Nrf2, and activation of Nrf2-dependent cancer-protective genes.	sulforaphane	5-17	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
14585973-7	2003	Both sulforaphane, a chemopreventive isothiocyanate, and oxidative stress enable Nrf2 to escape Keap1-dependent degradation, leading to stabilization of Nrf2, increased nuclear localization of Nrf2, and activation of Nrf2-dependent cancer-protective genes.	sulforaphane	5-17	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
14585973-8	2003	We have identified a third cysteine residue in Keap1, C151, that is uniquely required for inhibition of Keap1-dependent degradation of Nrf2 by sulforaphane and oxidative stress.	sulforaphane	143-155	kelch like ECH associated protein 1	Homo sapiens	47-52
14585973-8	2003	We have identified a third cysteine residue in Keap1, C151, that is uniquely required for inhibition of Keap1-dependent degradation of Nrf2 by sulforaphane and oxidative stress.	sulforaphane	143-155	kelch like ECH associated protein 1	Homo sapiens	104-109
14585973-8	2003	We have identified a third cysteine residue in Keap1, C151, that is uniquely required for inhibition of Keap1-dependent degradation of Nrf2 by sulforaphane and oxidative stress.	sulforaphane	143-155	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
12816537-5	2003	Examination of wild-type and nrf2 (-/-) mouse embryonic fibroblasts demonstrated that Nrf2 is essential for both constitutive expression of NQO1 and its induction by sulphoraphane.	sulforaphane	166-179	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
12816537-5	2003	Examination of wild-type and nrf2 (-/-) mouse embryonic fibroblasts demonstrated that Nrf2 is essential for both constitutive expression of NQO1 and its induction by sulphoraphane.	sulforaphane	166-179	NAD(P)H dehydrogenase, quinone 1	Mus musculus	140-144
11836580-9	2002	SFN and its metabolite SFN-NAC have similar activities to induce growth arrest and apoptosis, indicating that the effects of SFN are maintained through the metabolic processes.	sulforaphane	0-3	X-linked Kx blood group	Homo sapiens	27-30
12756216-8	2003	The changes in gene expression were also seen in differentiated Caco-2 cells, where sulforaphane was responsible for induction of GSTA1 and quercetin for induction of UGT1A1.	sulforaphane	84-96	glutathione S-transferase alpha 1	Homo sapiens	130-135
12756216-8	2003	The changes in gene expression were also seen in differentiated Caco-2 cells, where sulforaphane was responsible for induction of GSTA1 and quercetin for induction of UGT1A1.	sulforaphane	84-96	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	167-173
12651614-9	2003	Nuclear factor-kappa B translocation in SFs was triggered by TLR2-mediated cell stimulation.	sulforaphane	40-43	toll like receptor 2	Homo sapiens	61-65
12663510-0	2003	Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation.	sulforaphane	16-28	thioredoxin reductase 1	Homo sapiens	62-85
12663510-3	2003	We show that TrxR1 mRNA, but not TrxR2 mRNA, is induced up to 4-fold by sulforaphane, and this increase was abolished by actinomycin D, a transcription inhibitor.	sulforaphane	72-84	thioredoxin reductase 1	Homo sapiens	13-18
12663510-5	2003	In combination, sulforaphane and Se synergistically induced TrxR1 protein (5.5-fold), activity (13-fold) and mRNA (6.5-fold).	sulforaphane	16-28	thioredoxin reductase 1	Homo sapiens	60-65
12663510-6	2003	Although Se does not induce TrxR1 mRNA, Se can delay the degradation of sulforaphane-induced TrxR1 mRNA.	sulforaphane	72-84	thioredoxin reductase 1	Homo sapiens	93-98
12663510-7	2003	Modulation of TrxR1 mRNA by sulforaphane was glutathione and protein kinase C-dependent, as L-buthionine-S,R-sulfoximine (a specific inhibitor of glutathione synthesis), and the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine, significantly reduced the induction.	sulforaphane	28-40	thioredoxin reductase 1	Homo sapiens	14-19
12151360-0	2002	Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.	sulforaphane	0-12	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	109-115
12151360-0	2002	Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells.	sulforaphane	0-12	glutathione S-transferase alpha 1	Homo sapiens	146-151
12151360-2	2002	Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane and its glutathione conjugate, but not the nitrile, increased significantly (P < 0.05) both UGT1A1 and GSTA1 mRNA levels in HepG2 and HT29 cells.	sulforaphane	118-130	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	226-232
12151360-2	2002	Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane and its glutathione conjugate, but not the nitrile, increased significantly (P < 0.05) both UGT1A1 and GSTA1 mRNA levels in HepG2 and HT29 cells.	sulforaphane	118-130	glutathione S-transferase alpha 1	Homo sapiens	237-242
12151360-5	2002	The induction of UGT1A1 and GSTA1 mRNA by sulforaphane was time and concentration dependent.	sulforaphane	42-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	17-23
12151360-5	2002	The induction of UGT1A1 and GSTA1 mRNA by sulforaphane was time and concentration dependent.	sulforaphane	42-54	glutathione S-transferase alpha 1	Homo sapiens	28-33
12949356-0	2003	Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element.	sulforaphane	80-92	peroxiredoxin 5	Homo sapiens	0-21
12949356-1	2003	We previously reported the in vitro and in vivo induction of thioredoxin reductase (TR) by sulforaphane (SF) purified from broccoli.	sulforaphane	91-103	peroxiredoxin 5	Homo sapiens	61-82
12949356-1	2003	We previously reported the in vitro and in vivo induction of thioredoxin reductase (TR) by sulforaphane (SF) purified from broccoli.	sulforaphane	91-103	peroxiredoxin 5	Homo sapiens	84-86
12682069-4	2003	In the RL34 non-transformed rat liver cell line, Nrf2 was found to accumulate rapidly in response to oxidative stress caused by treatment with sulforaphane, and the accumulation resulted from inhibition of proteasomal-mediated degradation of the bZIP protein.	sulforaphane	143-155	NFE2 like bZIP transcription factor 2	Rattus norvegicus	49-53
12742546-0	2003	Induction of hepatic thioredoxin reductase activity by sulforaphane, both in Hepa1c1c7 cells and in male Fisher 344 rats.	sulforaphane	55-67	peroxiredoxin 2	Mus musculus	21-42
12530531-0	2002	Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes.	sulforaphane	26-38	cyclin D3	Homo sapiens	0-9
12530531-0	2002	Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes.	sulforaphane	26-38	tumor protein p53	Homo sapiens	14-17
12530531-2	2002	Following our previous demonstration that sulforaphane induces cell cycle arrest and apoptosis in human T lymphoblastoid Jurkat leukemia cells and increases p53 and bax protein expression, we tested sulforaphane on non-transformed phytohemagglutinin-stimulated human lymphocytes.	sulforaphane	42-54	tumor protein p53	Homo sapiens	157-160
12530531-2	2002	Following our previous demonstration that sulforaphane induces cell cycle arrest and apoptosis in human T lymphoblastoid Jurkat leukemia cells and increases p53 and bax protein expression, we tested sulforaphane on non-transformed phytohemagglutinin-stimulated human lymphocytes.	sulforaphane	42-54	BCL2 associated X, apoptosis regulator	Homo sapiens	165-168
12530531-3	2002	Here, we demonstrate that sulforaphane arrested cell cycle progression in G, phase, through a decrease in the protein expression of cyclin D3.	sulforaphane	26-38	cyclin D3	Homo sapiens	132-141
12530531-4	2002	Moreover, sulforaphane induced apoptosis (and also necrosis), mediated by an increase in the expression of p53.	sulforaphane	10-22	tumor protein p53	Homo sapiens	107-110
12234984-0	2002	Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.	sulforaphane	76-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
12234984-5	2002	Sulforaphane is a promising chemopreventive agent that exerts its effect by strong induction of phase 2 enzymes via activation of Nrf2.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	kelch-like ECH-associated protein 1	Mus musculus	46-51
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	kelch-like ECH-associated protein 1	Mus musculus	114-119
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	sulforaphane	214-226	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
11836580-9	2002	SFN and its metabolite SFN-NAC have similar activities to induce growth arrest and apoptosis, indicating that the effects of SFN are maintained through the metabolic processes.	sulforaphane	23-26	X-linked Kx blood group	Homo sapiens	27-30
12206135-4	2002	The chemical carcinogen 2-acetylaminofluorene and chemopreventive agents such as oltipraz and sulforaphane also markedly increased MRP2 expression in liver parenchymal cells.	sulforaphane	94-106	ATP binding cassette subfamily C member 2	Homo sapiens	131-135
11706044-0	2002	A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway.	sulforaphane	2-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-56
11743757-6	2001	Hepatic, colonic mucosal, and pancreatic quinone reductase and glutathione S-transferase activities were induced by high doses of SF, but not by SF nitrile.	sulforaphane	130-132	hematopoietic prostaglandin D synthase	Rattus norvegicus	63-88
12416265-3	2002	In this study, we compared the effects of seven daily oral doses of crambene (50 mg/kg rat/day) and sulforaphane (50 mg/kg rat/day) on induction of hepatic quinone reductase activity in Fischer 344 rats.	sulforaphane	100-112	crystallin, zeta	Mus musculus	156-173
12416265-4	2002	The two treatments produced similar effects, with crambene and sulforaphane producing 1.5- and 1.7-fold induction in hepatic quinone reductase activity, respectively.	sulforaphane	63-75	crystallin, zeta	Mus musculus	125-142
11593102-6	2001	Sulforaphane (0.05-1 micromol/l) and t-BHQ (10-100 micromol/l) induced significant and concentration-dependent increases in cellular GSH levels, HO-1 protein content and activities of GSH-reductase and GSH-peroxidase in SMCs from both rat strains.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	145-149
11535546-10	2001	Sulforaphane and broccoli sprout extract potently induce quinone reductase activity in cultured prostate cells, and this induction appears to be mediated by increased transcription of the NQO-1 gene.	sulforaphane	0-12	NAD(P)H quinone dehydrogenase 1	Homo sapiens	188-193
11535546-11	2001	Sulforaphane also induces expression of gamma-glutamylcysteine synthetase light subunit but not the heavy subunit, and this induction is associated with moderate increases in intracellular glutathione levels.	sulforaphane	0-12	glutamate-cysteine ligase catalytic subunit	Homo sapiens	40-73
11506817-10	2001	A model is proposed for BHA and SUL, in that at low concentrations, these potential chemopreventive agents may modulate MAPK pathway leading to transcription activation of Nrf2 and ARE with subsequent induction of cellular defensive enzymes including phase II detoxifying enzymes as well as other defensive genes, which may protect the cells against cellular injury, which is a homeostatic response.	sulforaphane	32-35	NFE2 like bZIP transcription factor 2	Homo sapiens	172-176
11264000-0	2001	Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane.	sulforaphane	132-144	ATP binding cassette subfamily C member 2	Rattus norvegicus	45-86
11410599-0	2001	Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.	sulforaphane	49-61	nuclear factor kappa B subunit 1	Homo sapiens	0-22
11410599-2	2001	Aiming to investigate anti-inflammatory mechanisms of SFN, we here report a potent decrease in lipopolysaccharide (LPS)-induced secretion of pro-inflammatory and pro-carcinogenic signaling factors in cultured Raw 264.7 macrophages after SFN treatment, i.e. NO, prostaglandin E(2), and tumor necrosis factor alpha.	sulforaphane	54-57	tumor necrosis factor	Homo sapiens	285-312
11507062-5	2001	By contrast, nontoxic doses of SUL, BITC, or PEITC failed to induce expression of CYP1A1 in LS-174 cells, but caused an increase of between 11- and 17-fold in the protein levels of AKR1C1, NQO1, and GCS(h).	sulforaphane	31-34	aldo-keto reductase family 1 member C1	Homo sapiens	181-187
11507062-6	2001	Treatment of the colon cell line with ICZ or SUL caused increases in the levels of mRNA for CYP1A1, AKR1C1, and NQO1 that were consistent with the enzyme data.	sulforaphane	45-48	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	92-98
11507062-6	2001	Treatment of the colon cell line with ICZ or SUL caused increases in the levels of mRNA for CYP1A1, AKR1C1, and NQO1 that were consistent with the enzyme data.	sulforaphane	45-48	aldo-keto reductase family 1 member C1	Homo sapiens	100-106
11507062-6	2001	Treatment of the colon cell line with ICZ or SUL caused increases in the levels of mRNA for CYP1A1, AKR1C1, and NQO1 that were consistent with the enzyme data.	sulforaphane	45-48	NAD(P)H quinone dehydrogenase 1	Homo sapiens	112-116
11768769-10	2001	Other phytochemicals including PEITC, and sulforaphane, also differentially regulated the activities of MAPKs, Nrf2, and ARE-mediated luciferase reporter gene activity and Phase II enzyme induction.	sulforaphane	42-54	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
11768769-11	2001	A model is proposed where these xenobiotics (BHA, tBHQ, GTP, EGCG, PEITC, sulforaphane) activate the MAPK pathway via an electrophilic-mediated stress response, leading to the transcription activation of Nrf2/Maf heterodimers on ARE/EpRE enhancers, with the subsequent induction of cellular defense/detoxifying genes including Phase II DMEs, which may protect the cells against toxic environmental insults and thereby enhance cell survival.	sulforaphane	74-86	mitogen-activated protein kinase 1	Homo sapiens	101-105
11768769-11	2001	A model is proposed where these xenobiotics (BHA, tBHQ, GTP, EGCG, PEITC, sulforaphane) activate the MAPK pathway via an electrophilic-mediated stress response, leading to the transcription activation of Nrf2/Maf heterodimers on ARE/EpRE enhancers, with the subsequent induction of cellular defense/detoxifying genes including Phase II DMEs, which may protect the cells against toxic environmental insults and thereby enhance cell survival.	sulforaphane	74-86	NFE2 like bZIP transcription factor 2	Homo sapiens	204-208
11768769-11	2001	A model is proposed where these xenobiotics (BHA, tBHQ, GTP, EGCG, PEITC, sulforaphane) activate the MAPK pathway via an electrophilic-mediated stress response, leading to the transcription activation of Nrf2/Maf heterodimers on ARE/EpRE enhancers, with the subsequent induction of cellular defense/detoxifying genes including Phase II DMEs, which may protect the cells against toxic environmental insults and thereby enhance cell survival.	sulforaphane	74-86	MAF bZIP transcription factor	Homo sapiens	209-212
11264000-1	2001	Expression of multidrug resistance-associated protein 2 (MRP2), an efflux pump contributing to biliary secretion of xenobiotics, was investigated in primary rat and human hepatocytes exposed to sulforaphane, a naturally-occurring chemopreventive agent.	sulforaphane	194-206	ATP binding cassette subfamily C member 2	Rattus norvegicus	14-55
11264000-1	2001	Expression of multidrug resistance-associated protein 2 (MRP2), an efflux pump contributing to biliary secretion of xenobiotics, was investigated in primary rat and human hepatocytes exposed to sulforaphane, a naturally-occurring chemopreventive agent.	sulforaphane	194-206	ATP binding cassette subfamily C member 2	Rattus norvegicus	57-61
11264000-2	2001	Northern blot indicated that sulforaphane increased MRP2 mRNA levels in primary rat hepatocytes; it also induced expression of drug metabolizing enzymes such as glutathione S-transferase A1/2 isoforms and NAD(P)H:quinone oxidoreductase in a dose-response and time-course manner similar to that observed for the upregulation of MRP2 transcripts.	sulforaphane	29-41	ATP binding cassette subfamily C member 2	Rattus norvegicus	52-56
11264000-2	2001	Northern blot indicated that sulforaphane increased MRP2 mRNA levels in primary rat hepatocytes; it also induced expression of drug metabolizing enzymes such as glutathione S-transferase A1/2 isoforms and NAD(P)H:quinone oxidoreductase in a dose-response and time-course manner similar to that observed for the upregulation of MRP2 transcripts.	sulforaphane	29-41	ATP binding cassette subfamily C member 2	Rattus norvegicus	327-331
11264000-5	2001	In addition to rat cells, primary human hepatocytes exposed to sulforaphane also displayed induced MRP2 expression evidenced at both mRNA and protein levels.	sulforaphane	63-75	ATP binding cassette subfamily C member 2	Homo sapiens	99-103
11264000-6	2001	All these observations strongly support the conclusion that the export pump MRP2 can be classified among the detoxifying proteins that are regulated by sulforaphane and that are thought to contribute, at least in part, to its anticarcinogenic properties.	sulforaphane	152-164	ATP binding cassette subfamily C member 2	Rattus norvegicus	76-80
11133247-3	2001	A number of phytochemicals can also potently inhibit CYP2E1 - most notably certain isothiocyanates found in crucifera, such as sulforaphane and phenethylisothiocyanate.	sulforaphane	127-139	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	53-59
10706716-5	2000	In this study we show that HIV-1IIIB efficiently binds to multimeric fibronectin (sFN) and that HIV infection of primary CD4+ lymphocytes is enhanced by >1 order of magnitude in the presence of sFN.	sulforaphane	82-85	fibronectin 1	Homo sapiens	69-80
10814878-8	2000	The expression of QR and GSTP1-1 proteins were increased by 3 to 4-fold and 3 to 5-fold, respectively, for MCF-10F cells treated with sulforaphane (0.5-2.0 microM).	sulforaphane	134-146	crystallin zeta	Homo sapiens	18-20
10814878-8	2000	The expression of QR and GSTP1-1 proteins were increased by 3 to 4-fold and 3 to 5-fold, respectively, for MCF-10F cells treated with sulforaphane (0.5-2.0 microM).	sulforaphane	134-146	glutathione S-transferase pi 1	Homo sapiens	25-32
10814878-11	2000	The inhibition of BP-DNA and 1, 6-DNP adduct formation by sulforaphane was associated with increases in QR and GST protein expression.	sulforaphane	58-70	crystallin zeta	Homo sapiens	104-106
10814878-11	2000	The inhibition of BP-DNA and 1, 6-DNP adduct formation by sulforaphane was associated with increases in QR and GST protein expression.	sulforaphane	58-70	glutathione S-transferase kappa 1	Homo sapiens	111-114
10834863-7	2000	MMP-7 and MMP-13 were detectable in more than 45% of RA SFs and in less than 20% of OA SFs, respectively.	sulforaphane	56-59	matrix metallopeptidase 7	Homo sapiens	0-5
10834863-7	2000	MMP-7 and MMP-13 were detectable in more than 45% of RA SFs and in less than 20% of OA SFs, respectively.	sulforaphane	56-59	matrix metallopeptidase 13	Homo sapiens	10-16
10834863-7	2000	MMP-7 and MMP-13 were detectable in more than 45% of RA SFs and in less than 20% of OA SFs, respectively.	sulforaphane	87-90	matrix metallopeptidase 7	Homo sapiens	0-5
10834863-7	2000	MMP-7 and MMP-13 were detectable in more than 45% of RA SFs and in less than 20% of OA SFs, respectively.	sulforaphane	87-90	matrix metallopeptidase 13	Homo sapiens	10-16
10644681-8	2000	In addition, inhibition of p38 activity augmented the induction of ARE reporter gene activity by tert-butylhydroxyanisole, sulforaphane, and beta-naphthoflavone.	sulforaphane	123-135	mitogen-activated protein kinase 14	Homo sapiens	27-30
10376975-5	1999	DT-diaphorase was induced by many dietary inducers, including propyl gallate, dimethyl maleate, dimethyl fumarate and sulforaphane.	sulforaphane	118-130	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
10488090-9	1999	Indeed, both tBHQ and SUL were able to stimulate Raf-1 kinase activity in vivo as well as in vitro.	sulforaphane	22-25	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	49-54
10919717-7	1999	Although thrombin treatment increased adherence, pre-incubation of the tumor cells with sFn resulted in a further increase in platelet binding to tumor cells.	sulforaphane	88-91	coagulation factor II	Mus musculus	9-17
10226522-5	1999	With cultured Hepa 1c1c7 cells, sulforaphane and 1,2-dithiole-3-thione mediated strong induction of quinone reductase, and genistein and ursolic acid were moderate inducers.	sulforaphane	32-44	crystallin, zeta	Mus musculus	100-117
9600344-2	1998	4-Methylsulphinylbutyl isothiocyanate (sulphoraphane), derived from the corresponding glucosinolate found in broccoli, has previously been identified as a potent inducer of the anticarcinogenic marker enzyme quinone reductase [NADP(H):quinone-acceptor oxidoreductase] in murine hepatoma Hepa 1c1c7 cells.	sulforaphane	39-52	crystallin, zeta	Mus musculus	208-225
9855024-7	1998	Gastric rGSTT1-1 protein levels were enhanced by alpha-angelicalactone, alpha-tocopherol, coumarin, ellagic acid, oltipraz, PEITC and the sulphoraphane analogue compound-30.	sulforaphane	138-151	glutathione S-transferase theta 1	Rattus norvegicus	8-16
9675256-5	1998	The ability of sulforaphane to inhibit both CYP2E1 and CYP1A2-mediated genotoxicity therefore is relevant to human isoforms of these enzymes and may contribute to a chemopreventative activity.	sulforaphane	15-27	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	44-50
9675256-5	1998	The ability of sulforaphane to inhibit both CYP2E1 and CYP1A2-mediated genotoxicity therefore is relevant to human isoforms of these enzymes and may contribute to a chemopreventative activity.	sulforaphane	15-27	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	55-61
33819785-4	2021	Low-level methionine content and downregulated SOT18 were the main factors inhibiting GSLs and sulforaphane accumulation under blue LED illumination.	sulforaphane	95-107	small integral membrane protein 10 like 2A	Homo sapiens	132-135
9230294-0	1997	Re: Barcelo, S., Gardiner, J.M., and Gescher, A. and Chipman, J.K. (1996) CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane.	sulforaphane	149-161	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	74-80
8625450-0	1996	CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane.	sulforaphane	75-87	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	0-6
8625450-2	1996	We investigated the ability of sulforaphane to also inhibit the phase I enzyme cytochrome P450 isoenzyme 2E1 (CYP2E1), which is responsible for activation of several carcinogens, including dialkylnitrosamines.	sulforaphane	31-43	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	110-116
8625450-3	1996	Using the p-nitrophenol hydroxylation assay in microsomes from livers of acetone-treated Sprague-Dawley rats, sulforaphane was shown to be a potent competitive inhibitor of CYP2E1 with a Ki of 37.0 +/- 4.5 microM.	sulforaphane	110-122	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	173-179
8625450-9	1996	These findings suggest that inhibition of CYP2E1 by sulforaphane may offer chemoprotection against carcinogenic substrates of this enzyme.	sulforaphane	52-64	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	42-48
9545594-4	1998	Sulforaphane analog compound 30 enhanced GST activity in all organs studied (1.2-2.4 x).	sulforaphane	0-12	glutathione S-transferase kappa 1	Homo sapiens	41-44
1549603-9	1992	Sulforaphane and its sulfide and sulfone analogues induced both quinone reductase and glutathione transferase activities in several mouse tissues.	sulforaphane	0-12	crystallin, zeta	Mus musculus	64-81
33774519-1	2021	Sulforaphane(SFN) and erucin(ERN) are isothiocyanates (ITCs) bearing, respectively, methylsulfinyl and methylsulfanyl groups.	sulforaphane	0-12	RNA exonuclease 2	Homo sapiens	13-16
33819468-0	2021	miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.	sulforaphane	68-80	collagen type III alpha 1 chain	Homo sapiens	21-27
33819468-0	2021	miR-29a-3p-dependent COL3A1 and COL5A1 expression reduction assists sulforaphane to inhibit gastric cancer progression.	sulforaphane	68-80	collagen type V alpha 1 chain	Homo sapiens	32-38
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	183-195	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	8-13
33590951-10	2021	Pretreatment of MDMs from COPD patients with SFN significantly suppressed Pam3CSK4- or LPS-induced TLR2, TLR4 and MyD88 expression, along with a reduction in the production of IL-6 and TNF-alpha (P < 0.05).	sulforaphane	45-48	toll like receptor 2	Homo sapiens	99-103
33590951-10	2021	Pretreatment of MDMs from COPD patients with SFN significantly suppressed Pam3CSK4- or LPS-induced TLR2, TLR4 and MyD88 expression, along with a reduction in the production of IL-6 and TNF-alpha (P < 0.05).	sulforaphane	45-48	toll like receptor 4	Homo sapiens	105-109
33590951-10	2021	Pretreatment of MDMs from COPD patients with SFN significantly suppressed Pam3CSK4- or LPS-induced TLR2, TLR4 and MyD88 expression, along with a reduction in the production of IL-6 and TNF-alpha (P < 0.05).	sulforaphane	45-48	MYD88 innate immune signal transduction adaptor	Homo sapiens	114-119
33590951-10	2021	Pretreatment of MDMs from COPD patients with SFN significantly suppressed Pam3CSK4- or LPS-induced TLR2, TLR4 and MyD88 expression, along with a reduction in the production of IL-6 and TNF-alpha (P < 0.05).	sulforaphane	45-48	interleukin 6	Homo sapiens	176-180
33590951-10	2021	Pretreatment of MDMs from COPD patients with SFN significantly suppressed Pam3CSK4- or LPS-induced TLR2, TLR4 and MyD88 expression, along with a reduction in the production of IL-6 and TNF-alpha (P < 0.05).	sulforaphane	45-48	tumor necrosis factor	Homo sapiens	185-194
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	183-195	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	97-102
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	183-195	histone deacetylase 3	Rattus norvegicus	143-164
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	183-195	histone deacetylase 3	Rattus norvegicus	166-171
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	197-200	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	8-13
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	197-200	histone deacetylase 3	Rattus norvegicus	143-164
33809839-6	2021	Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells, plus Ercc2 in rat tumors, after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family.	sulforaphane	197-200	histone deacetylase 3	Rattus norvegicus	166-171
33032098-10	2020	In mouse mesenteric arteries, sulforaphane reduced contraction evoked by potassium (p < 0.001), phenylephrine and endothelin 1 (all p < 0.001).	sulforaphane	30-42	endothelin 1	Mus musculus	114-126
33805772-2	2021	Sulforaphane potently induces transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated expression of detoxification, anti-oxidation, and immune system-modulating enzymes, and possibly acts as an anti-carcinogenic agent.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	51-94
33805772-2	2021	Sulforaphane potently induces transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated expression of detoxification, anti-oxidation, and immune system-modulating enzymes, and possibly acts as an anti-carcinogenic agent.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
33805772-5	2021	Animal and cell studies that employ sulforaphane against memory impairment and AD-related pre-clinical biomarkers on amyloid-beta, tau, inflammation, oxidative stress, and neurodegeneration are summarized, and plausible neuroprotective mechanisms of sulforaphane to help prevent AD are discussed.	sulforaphane	36-48	amyloid beta precursor protein	Homo sapiens	117-129
33805772-5	2021	Animal and cell studies that employ sulforaphane against memory impairment and AD-related pre-clinical biomarkers on amyloid-beta, tau, inflammation, oxidative stress, and neurodegeneration are summarized, and plausible neuroprotective mechanisms of sulforaphane to help prevent AD are discussed.	sulforaphane	36-48	microtubule associated protein tau	Homo sapiens	131-134
33426091-13	2020	Activation of nrf2 by sulforaphane (SFN) profoundly inhibited the TNF-alpha-induced proliferation and invasion of RA-FLS.	sulforaphane	22-34	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
33426091-13	2020	Activation of nrf2 by sulforaphane (SFN) profoundly inhibited the TNF-alpha-induced proliferation and invasion of RA-FLS.	sulforaphane	22-34	tumor necrosis factor	Homo sapiens	66-75
33426091-13	2020	Activation of nrf2 by sulforaphane (SFN) profoundly inhibited the TNF-alpha-induced proliferation and invasion of RA-FLS.	sulforaphane	36-39	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
33426091-13	2020	Activation of nrf2 by sulforaphane (SFN) profoundly inhibited the TNF-alpha-induced proliferation and invasion of RA-FLS.	sulforaphane	36-39	tumor necrosis factor	Homo sapiens	66-75
32859007-0	2020	Sulforaphane Inhibits MGO-AGE-Mediated Neuroinflammation by Suppressing NF-kappaB, MAPK, and AGE-RAGE Signaling Pathways in Microglial Cells.	sulforaphane	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
32859007-0	2020	Sulforaphane Inhibits MGO-AGE-Mediated Neuroinflammation by Suppressing NF-kappaB, MAPK, and AGE-RAGE Signaling Pathways in Microglial Cells.	sulforaphane	0-12	advanced glycosylation end product-specific receptor	Mus musculus	97-101
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	sulforaphane	143-155	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	sulforaphane	143-155	coagulation factor III, tissue factor	Homo sapiens	192-194
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	sulforaphane	143-155	coagulation factor III, tissue factor	Homo sapiens	192-194
33814512-5	2021	We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs.	sulforaphane	143-155	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33032098-13	2020	In human omental arteries, sulforaphane induced vasodilation (p < 0.001), and prevented PEM-induced endothelial dysfunction by restoring arterial sensitivity to the endothelium-dependent vasodilator bradykinin (p = 0.008).	sulforaphane	27-39	kininogen 1	Homo sapiens	199-209
34655754-0	2022	Anti-obesity effect of sulforaphane in broccoli leaf extract on 3T3-L1 adipocytes and ob/ob mice.	sulforaphane	23-35	leptin	Mus musculus	86-88
33034881-0	2020	Sulforaphane modulates CX3CL1/CX3CR1 axis and inflammation in palmitic acid-induced cell injury in C2C12 skeletal muscle cells.	sulforaphane	0-12	chemokine (C-X3-C motif) ligand 1	Mus musculus	23-29
33034881-0	2020	Sulforaphane modulates CX3CL1/CX3CR1 axis and inflammation in palmitic acid-induced cell injury in C2C12 skeletal muscle cells.	sulforaphane	0-12	chemokine (C-X3-C motif) receptor 1	Mus musculus	30-36
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	TIMP metallopeptidase inhibitor 1	Homo sapiens	47-52
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	aurora kinase A	Homo sapiens	54-59
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	centrosomal protein 55	Homo sapiens	65-70
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	crystallin alpha B	Homo sapiens	99-104
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	phospholipase C epsilon 1	Homo sapiens	106-111
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	matrix metallopeptidase 28	Homo sapiens	117-122
34959120-7	2022	Sulforaphane potentiates the overexpression of TIMP1, AURKA, and CEP55, and promotes inhibition of CRYAB, PLCE1, and MMP28, that might lead to the progression of CRC (CTD).	sulforaphane	0-12	CTD	Homo sapiens	167-170
34655754-0	2022	Anti-obesity effect of sulforaphane in broccoli leaf extract on 3T3-L1 adipocytes and ob/ob mice.	sulforaphane	23-35	leptin	Mus musculus	89-91
34655754-6	2022	Treatment with SFN and BLE significantly reduced (P < 0.05) TG content, low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), and glucose in the serum of ob/ob mice.	sulforaphane	15-18	leptin	Mus musculus	167-169
34655754-6	2022	Treatment with SFN and BLE significantly reduced (P < 0.05) TG content, low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), and glucose in the serum of ob/ob mice.	sulforaphane	15-18	leptin	Mus musculus	170-172
34823019-8	2022	We also observed the effects of sulforaphane (SFN), a Nrf2 activator, in restoring mitochondrial function in senescent C2C12 cells and improving sarcopenia in older WT mice, which were abolished by Nrf2 deficiency.	sulforaphane	32-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
34610184-0	2022	Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity.	sulforaphane	0-12	transglutaminase 2	Homo sapiens	43-61
34731371-0	2022	mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma.	sulforaphane	53-65	mechanistic target of rapamycin kinase	Homo sapiens	0-4
34731371-0	2022	mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma.	sulforaphane	53-65	AKT serine/threonine kinase 1	Homo sapiens	78-81
34731371-0	2022	mTOR inhibitor PP242 increases antitumor activity of sulforaphane by blocking Akt/mTOR pathway in esophageal squamous cell carcinoma.	sulforaphane	53-65	mechanistic target of rapamycin kinase	Homo sapiens	82-86
34731371-9	2022	The mechanism was that PP242 abrogated the promoting effects of SFN on p-p70S6K (Thr389) and p-Akt (Ser473) in ESCC.	sulforaphane	64-67	ribosomal protein S6 kinase B1	Homo sapiens	73-79
34731371-9	2022	The mechanism was that PP242 abrogated the promoting effects of SFN on p-p70S6K (Thr389) and p-Akt (Ser473) in ESCC.	sulforaphane	64-67	AKT serine/threonine kinase 1	Homo sapiens	95-98
34791822-0	2022	AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.	sulforaphane	73-85	AKT serine/threonine kinase 1	Homo sapiens	0-4
34791822-0	2022	AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.	sulforaphane	73-85	hexokinase 2	Homo sapiens	5-8
34823019-8	2022	We also observed the effects of sulforaphane (SFN), a Nrf2 activator, in restoring mitochondrial function in senescent C2C12 cells and improving sarcopenia in older WT mice, which were abolished by Nrf2 deficiency.	sulforaphane	32-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	198-202
34823019-8	2022	We also observed the effects of sulforaphane (SFN), a Nrf2 activator, in restoring mitochondrial function in senescent C2C12 cells and improving sarcopenia in older WT mice, which were abolished by Nrf2 deficiency.	sulforaphane	46-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
34823019-8	2022	We also observed the effects of sulforaphane (SFN), a Nrf2 activator, in restoring mitochondrial function in senescent C2C12 cells and improving sarcopenia in older WT mice, which were abolished by Nrf2 deficiency.	sulforaphane	46-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	198-202
34926464-0	2021	Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan.	sulforaphane	0-12	Sex-determining transformer protein 1	Caenorhabditis elegans	21-26
34960110-3	2021	Sulforaphane (SFN) is a natural isothiocyanate with anti-inflammatory and anti-oxidative properties via its activation of Nrf2 signalling that has been shown to improve aspects of the skeletal muscle pathology in dystrophic mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
34960110-3	2021	Sulforaphane (SFN) is a natural isothiocyanate with anti-inflammatory and anti-oxidative properties via its activation of Nrf2 signalling that has been shown to improve aspects of the skeletal muscle pathology in dystrophic mice.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
34926464-0	2021	Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan.	sulforaphane	0-12	GLI family zinc finger 1	Homo sapiens	27-30
34926464-0	2021	Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote C. elegans Longevity and Healthspan.	sulforaphane	0-12	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	43-49
34926464-6	2021	In the wild type, sulforaphane prolonged lifespan and increased mobility and food intake because of sulforaphane-induced upregulation of the sex-determination transcription factor TRA-1, which is the ortholog of the human GLI mediator of sonic hedgehog signaling.	sulforaphane	18-30	transformation/transcription domain associated protein	Homo sapiens	180-185
34926464-6	2021	In the wild type, sulforaphane prolonged lifespan and increased mobility and food intake because of sulforaphane-induced upregulation of the sex-determination transcription factor TRA-1, which is the ortholog of the human GLI mediator of sonic hedgehog signaling.	sulforaphane	18-30	GLI family zinc finger 1	Homo sapiens	222-225
34926464-6	2021	In the wild type, sulforaphane prolonged lifespan and increased mobility and food intake because of sulforaphane-induced upregulation of the sex-determination transcription factor TRA-1, which is the ortholog of the human GLI mediator of sonic hedgehog signaling.	sulforaphane	100-112	transformation/transcription domain associated protein	Homo sapiens	180-185
34926464-6	2021	In the wild type, sulforaphane prolonged lifespan and increased mobility and food intake because of sulforaphane-induced upregulation of the sex-determination transcription factor TRA-1, which is the ortholog of the human GLI mediator of sonic hedgehog signaling.	sulforaphane	100-112	GLI family zinc finger 1	Homo sapiens	222-225
34926464-10	2021	Our data suggest the involvement of sulforaphane in regulating healthy aging and prolonging lifespan by inducing the expression and nuclear translocation of TRA-1/GLI and its downstream target DAF-16/FOXO.	sulforaphane	36-48	Sex-determining transformer protein 1	Caenorhabditis elegans	157-162
34926464-10	2021	Our data suggest the involvement of sulforaphane in regulating healthy aging and prolonging lifespan by inducing the expression and nuclear translocation of TRA-1/GLI and its downstream target DAF-16/FOXO.	sulforaphane	36-48	GLI family zinc finger 1	Homo sapiens	163-166
34926464-10	2021	Our data suggest the involvement of sulforaphane in regulating healthy aging and prolonging lifespan by inducing the expression and nuclear translocation of TRA-1/GLI and its downstream target DAF-16/FOXO.	sulforaphane	36-48	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	193-199
34308769-0	2021	Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1alpha pathway.	sulforaphane	0-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114
34982643-0	2021	Sulforaphane ameliorates amyloid-beta-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells.	sulforaphane	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	85-90
34982643-0	2021	Sulforaphane ameliorates amyloid-beta-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells.	sulforaphane	0-12	sirtuin 1	Homo sapiens	91-96
34982643-7	2021	Sulforaphane also mitigated the injury due to oligomeric amyloid-beta1-42 through a mechanism involving inactivation of the PARP1/SIRT1 pathway.	sulforaphane	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	124-129
34982643-7	2021	Sulforaphane also mitigated the injury due to oligomeric amyloid-beta1-42 through a mechanism involving inactivation of the PARP1/SIRT1 pathway.	sulforaphane	0-12	sirtuin 1	Homo sapiens	130-135
34982643-9	2021	Moreover, sulforaphane can induce cell viability and SIRT1 expression, but reduce cell apoptosis, the activity of caspase-3 or -9, and PARP1 expression in oAbeta1-42-treated cells.	sulforaphane	10-22	sirtuin 1	Homo sapiens	53-58
34982643-9	2021	Moreover, sulforaphane can induce cell viability and SIRT1 expression, but reduce cell apoptosis, the activity of caspase-3 or -9, and PARP1 expression in oAbeta1-42-treated cells.	sulforaphane	10-22	caspase 3	Homo sapiens	114-129
34982643-9	2021	Moreover, sulforaphane can induce cell viability and SIRT1 expression, but reduce cell apoptosis, the activity of caspase-3 or -9, and PARP1 expression in oAbeta1-42-treated cells.	sulforaphane	10-22	poly(ADP-ribose) polymerase 1	Homo sapiens	135-140
34982643-11	2021	In summary, sulforaphane reduces the inflammatory injury induced by oAbeta1-42 in ARPE-19 cell by inactivating the PARP1/SIRT1 pathway.	sulforaphane	12-24	poly(ADP-ribose) polymerase 1	Homo sapiens	115-120
34982643-11	2021	In summary, sulforaphane reduces the inflammatory injury induced by oAbeta1-42 in ARPE-19 cell by inactivating the PARP1/SIRT1 pathway.	sulforaphane	12-24	sirtuin 1	Homo sapiens	121-126
34308769-0	2021	Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1alpha pathway.	sulforaphane	0-12	sirtuin 1	Homo sapiens	115-120
34308769-0	2021	Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1alpha pathway.	sulforaphane	0-12	PPARG coactivator 1 alpha	Homo sapiens	121-131
34308769-7	2021	Sulforaphane weakened LPS-induced increases in intestinal epithelial cell permeability and oxidative stress (based on assays of reactive oxygen species, DMA, and H2O2), and it increased levels of antioxidants (SOD, GPx, CAT and T-AOC).	sulforaphane	0-12	superoxide dismutase 1	Homo sapiens	210-213
34308769-7	2021	Sulforaphane weakened LPS-induced increases in intestinal epithelial cell permeability and oxidative stress (based on assays of reactive oxygen species, DMA, and H2O2), and it increased levels of antioxidants (SOD, GPx, CAT and T-AOC).	sulforaphane	0-12	catalase	Homo sapiens	220-223
34308769-8	2021	At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9.	sulforaphane	18-30	interleukin 1 alpha	Homo sapiens	107-115
34308769-8	2021	At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9.	sulforaphane	18-30	interleukin 6	Homo sapiens	117-121
34308769-8	2021	At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9.	sulforaphane	18-30	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
34308769-8	2021	At the same time, sulforaphane weakened the ability of LPS to induce production of inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-alpha) and the pro-apoptotic caspases-3 and -9.	sulforaphane	18-30	tumor necrosis factor	Homo sapiens	132-141
34308769-9	2021	Sulforaphane also upregulated p-AMPK, SIRT1, and PGC-1alpha, whose inhibitors antagonized the compound"s protective effects.	sulforaphane	0-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	32-36
34308769-9	2021	Sulforaphane also upregulated p-AMPK, SIRT1, and PGC-1alpha, whose inhibitors antagonized the compound"s protective effects.	sulforaphane	0-12	sirtuin 1	Homo sapiens	38-43
34308769-9	2021	Sulforaphane also upregulated p-AMPK, SIRT1, and PGC-1alpha, whose inhibitors antagonized the compound"s protective effects.	sulforaphane	0-12	PPARG coactivator 1 alpha	Homo sapiens	49-59
34829721-0	2021	Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
34749521-0	2021	Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway.	sulforaphane	0-12	microRNA 4521	Homo sapiens	103-111
34749521-0	2021	Sulforaphane suppresses autophagy during the malignant progression of gastric carcinoma via activating miR-4521/PIK3R3 pathway.	sulforaphane	0-12	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	112-118
34749521-9	2021	MiR-4521 inhibition or PIK3R3 over-expression weakened the anti-cancer functions of sulforaphane in gastric carcinoma cells.	sulforaphane	84-96	microRNA 4521	Homo sapiens	0-8
34749521-9	2021	MiR-4521 inhibition or PIK3R3 over-expression weakened the anti-cancer functions of sulforaphane in gastric carcinoma cells.	sulforaphane	84-96	phosphoinositide-3-kinase regulatory subunit 3	Homo sapiens	23-29
34749521-11	2021	Thus, miR-4521 may be applied as a therapeutic target for sulforaphane in gastric carcinoma.	sulforaphane	58-70	microRNA 4521	Homo sapiens	6-14
34717147-0	2021	Inhibitory effects of sulforaphane on NLRP3 inflammasome activation.	sulforaphane	22-34	NLR family pyrin domain containing 3	Homo sapiens	38-43
34927380-2	2021	Sulforaphane activates nuclear factor erythroid 2-related factor 2 (Nrf2) and induces a protective effect against oxidative stress.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	23-66
34927380-2	2021	Sulforaphane activates nuclear factor erythroid 2-related factor 2 (Nrf2) and induces a protective effect against oxidative stress.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
34927380-11	2021	RESULTS: Sulforaphane supplement intake for 2 weeks increased NQO1 mRNA expression in peripheral blood mononuclear cells (PBMCs).	sulforaphane	9-21	NAD(P)H quinone dehydrogenase 1	Homo sapiens	62-66
34927380-14	2021	CONCLUSION: Our findings suggest that sulforaphane intake from 2 weeks before to 4 days after the exercise increased NQO1, a target gene of Nrf2, and suppressed DOMS after 2 days of eccentric exercise.	sulforaphane	38-50	NAD(P)H quinone dehydrogenase 1	Homo sapiens	117-121
34927380-14	2021	CONCLUSION: Our findings suggest that sulforaphane intake from 2 weeks before to 4 days after the exercise increased NQO1, a target gene of Nrf2, and suppressed DOMS after 2 days of eccentric exercise.	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
34819055-0	2021	Sulforaphane enhances the antitumor response of chimeric antigen receptor T cells by regulating PD-1/PD-L1 pathway.	sulforaphane	0-12	CD274 molecule	Homo sapiens	101-106
34819055-2	2021	Sulforaphane (SFN) is known to play an important role in inhibiting tumor growth, but its effect on CAR-T cells remains unclear.	sulforaphane	0-12	CXADR pseudogene 1	Homo sapiens	100-103
34942977-3	2021	To investigate the prenatal antioxidant effect on neonatal oxidative lung injury, time-pregnant Nrf2-/- and Nrf2+/+ mice were given an oral NRF2 agonist (sulforaphane) on embryonic days 11.5-17.5, and offspring were exposed to hyperoxia.	sulforaphane	154-166	nuclear factor, erythroid derived 2, like 2	Mus musculus	140-144
34942962-6	2021	Additionally, we discussed the phytochemicals like curcumin, quercetin, resveratrol, epigallocatechin gallate, apigenin, sulforaphane, and ursolic acid that have effectively modified NRF2 signaling and prevented various diseases in both in vitro and in vivo models.	sulforaphane	121-133	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	solute carrier family 10 member 1	Homo sapiens	70-74
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	solute carrier family 51 subunit alpha	Homo sapiens	76-84
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	ATP binding cassette subfamily G member 5	Homo sapiens	86-91
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	93-99
34767876-7	2021	Activation of NRF2 by sulforaphane also resulted in downregulation of NTCP, OSTalpha, ABCG5, CYP7A1 and CYP8B1.	sulforaphane	22-34	cytochrome P450 family 8 subfamily B member 1	Homo sapiens	104-110
34854886-12	2021	SFN significantly depleted GSH, the major antioxidant in the eye, and reduced GR activity, despite doubling its protein levels.	sulforaphane	0-3	glutathione-disulfide reductase	Homo sapiens	78-80
34271100-0	2021	Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway.	sulforaphane	29-41	kelch-like ECH-associated protein 1	Mus musculus	91-96
34271100-0	2021	Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway.	sulforaphane	29-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
34271100-2	2021	Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-pathway, which is important in controlling inflammation and oxidative stress that occur during aging, can be triggered by sulforaphane (SFN), an isothiocyanate found in plants from the Brassicaceae family.	sulforaphane	191-203	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-61
34271100-2	2021	Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-pathway, which is important in controlling inflammation and oxidative stress that occur during aging, can be triggered by sulforaphane (SFN), an isothiocyanate found in plants from the Brassicaceae family.	sulforaphane	191-203	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
34271100-2	2021	Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-pathway, which is important in controlling inflammation and oxidative stress that occur during aging, can be triggered by sulforaphane (SFN), an isothiocyanate found in plants from the Brassicaceae family.	sulforaphane	205-208	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-61
34271100-2	2021	Activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-pathway, which is important in controlling inflammation and oxidative stress that occur during aging, can be triggered by sulforaphane (SFN), an isothiocyanate found in plants from the Brassicaceae family.	sulforaphane	205-208	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
34678578-0	2021	The protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling pathway.	sulforaphane	25-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	154-158
34678578-0	2021	The protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling pathway.	sulforaphane	25-37	AKT serine/threonine kinase 1	Homo sapiens	159-162
34678578-0	2021	The protective effect of sulforaphane against oxidative stress in granulosa cells of patients with polycystic ovary syndrome (PCOS) through activation of AMPK/AKT/NRF2 signaling pathway.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
34678578-2	2021	Sulforaphane (SFN) has received a great deal of attention as potent antioxidant because of its ability to induce expression of antioxidant enzymes through nuclear factor (erythroid-derived 2)-like 2 (NRF2) signaling pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	155-198
34678578-2	2021	Sulforaphane (SFN) has received a great deal of attention as potent antioxidant because of its ability to induce expression of antioxidant enzymes through nuclear factor (erythroid-derived 2)-like 2 (NRF2) signaling pathway.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
34678578-2	2021	Sulforaphane (SFN) has received a great deal of attention as potent antioxidant because of its ability to induce expression of antioxidant enzymes through nuclear factor (erythroid-derived 2)-like 2 (NRF2) signaling pathway.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	155-198
34678578-2	2021	Sulforaphane (SFN) has received a great deal of attention as potent antioxidant because of its ability to induce expression of antioxidant enzymes through nuclear factor (erythroid-derived 2)-like 2 (NRF2) signaling pathway.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	200-204
34678578-10	2021	Our findings demonstrated the protective effect of SFN against OS by lowering level of ROS and apoptosis possibly through activation of AMPK, AKT, and NRF2 proteins and genes expression.	sulforaphane	51-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	136-140
34678578-10	2021	Our findings demonstrated the protective effect of SFN against OS by lowering level of ROS and apoptosis possibly through activation of AMPK, AKT, and NRF2 proteins and genes expression.	sulforaphane	51-54	AKT serine/threonine kinase 1	Homo sapiens	142-145
34678578-10	2021	Our findings demonstrated the protective effect of SFN against OS by lowering level of ROS and apoptosis possibly through activation of AMPK, AKT, and NRF2 proteins and genes expression.	sulforaphane	51-54	NFE2 like bZIP transcription factor 2	Homo sapiens	151-155
34942977-10	2021	In utero sulforaphane intervention suggested NRF2-dependent and -independent pulmonary protection mechanisms against early-life oxidant injury.	sulforaphane	9-21	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
34829721-0	2021	Sulforaphane-Mediated Nrf2 Activation Prevents Radiation-Induced Skin Injury through Inhibiting the Oxidative-Stress-Activated DNA Damage and NLRP3 Inflammasome.	sulforaphane	0-12	NLR family, pyrin domain containing 3	Mus musculus	142-147
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	83-86
34363387-8	2021	Activation of rat Leydig cells Sirt1 with honokiol or of Nrf2 with sulforaphane resulted in the maintenance of testosterone production despite the exposure of the cells to oxidizing agent.	sulforaphane	67-79	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
34775646-0	2021	EGF-functionalized lipid-polymer hybrid nanoparticles of 5-Fluorouracil and Sulphoraphane with enhanced bioavailability and anticancer activity against colon carcinoma.	sulforaphane	76-89	epidermal growth factor	Homo sapiens	0-3
34775646-2	2021	The epidermal growth factor (EGF)-functionalized LPHNPs co-loaded with 5-fluorouracil (FU) and Sulforaphane (SFN) were prepared by one-step nanoprecipitation method.	sulforaphane	95-107	epidermal growth factor	Homo sapiens	4-27
34775646-2	2021	The epidermal growth factor (EGF)-functionalized LPHNPs co-loaded with 5-fluorouracil (FU) and Sulforaphane (SFN) were prepared by one-step nanoprecipitation method.	sulforaphane	95-107	epidermal growth factor	Homo sapiens	29-32
34775646-2	2021	The epidermal growth factor (EGF)-functionalized LPHNPs co-loaded with 5-fluorouracil (FU) and Sulforaphane (SFN) were prepared by one-step nanoprecipitation method.	sulforaphane	109-112	epidermal growth factor	Homo sapiens	4-27
34775646-2	2021	The epidermal growth factor (EGF)-functionalized LPHNPs co-loaded with 5-fluorouracil (FU) and Sulforaphane (SFN) were prepared by one-step nanoprecipitation method.	sulforaphane	109-112	epidermal growth factor	Homo sapiens	29-32
34939763-0	2021	The Protective Effect of Sulforaphane against Oxidative Stress through Activation of NRF2/ARE Pathway in Human Granulosa Cells.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
34939763-1	2021	Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signaling pathway and the downstream antioxidant enzymes.	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Homo sapiens	122-165
34939763-1	2021	Objective: Sulforaphane (SFN) is a natural free radical scavenger that can reduce oxidative stress (OS) through mediating nuclear factor (erythroid-derived 2)-like 2 (NF-E2-related factor 2 or NRF2)/antioxidant response element (ARE) signaling pathway and the downstream antioxidant enzymes.	sulforaphane	11-23	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
34690024-10	2021	Importantly, BaP-conditioned medium-induced DNA damage and POMC secretion is prevented by antioxidants vitamin E, vitamin C and sulforaphane, as well as the prototypical corticosteroid dexamethasone.	sulforaphane	128-140	proopiomelanocortin	Homo sapiens	59-63
34772403-10	2021	The restoration of Nrf2 expression or treatment with the Nrf2 activator sulforaphane counteracted the inhibitory effect of Nestin knockdown on the proliferation, migration, invasion, and antioxidant enzyme production in GC cells.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
34772403-10	2021	The restoration of Nrf2 expression or treatment with the Nrf2 activator sulforaphane counteracted the inhibitory effect of Nestin knockdown on the proliferation, migration, invasion, and antioxidant enzyme production in GC cells.	sulforaphane	72-84	nestin	Homo sapiens	123-129
34082508-0	2021	Sulforaphane Ameliorates Diabetes-Induced Renal Fibrosis through Epigenetic Up-Regulation of BMP-7.	sulforaphane	0-12	bone morphogenetic protein 7	Homo sapiens	93-98
34082508-1	2021	Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity.	sulforaphane	30-42	histone deacetylase 9	Homo sapiens	129-148
34082508-1	2021	Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity.	sulforaphane	30-42	histone deacetylase 9	Homo sapiens	150-154
34082508-1	2021	Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity.	sulforaphane	44-47	histone deacetylase 9	Homo sapiens	129-148
34082508-1	2021	Background: The dietary agent sulforaphane (SFN) has been reported to reduce diabetes-induced renal fibrosis, as well as inhibit histone deacetylase (HDAC) activity.	sulforaphane	44-47	histone deacetylase 9	Homo sapiens	150-154
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	tumor necrosis factor	Rattus norvegicus	123-132
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	interleukin 1 alpha	Rattus norvegicus	134-142
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	144-149
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	nitric oxide synthase 2	Rattus norvegicus	151-155
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	189-192
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	caspase 3	Rattus norvegicus	194-203
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	BCL2, apoptosis regulator	Rattus norvegicus	270-275
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	281-285
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	286-290
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	300-304
34174694-8	2021	Sulforaphane downregulated the expressions of liver function-related factors (ALT, AST, TB), inflammation-related factors (TNF-alpha, IL-1beta, COX-2, iNOS), and apoptosis-related factors (Bax, Caspase-3) and upregulated the expressions of factors related to apoptosis (Bcl-2) and Nrf2/HO-1 pathway (Nrf2, HO-1).	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	306-310
34174694-9	2021	CONCLUSION: Sulforaphane protected the liver against traumatic hemorrhagic shock through ameliorating the apoptosis and inflammation of the liver via activating the Nrf2/HO-1 pathway.	sulforaphane	12-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	165-169
34174694-9	2021	CONCLUSION: Sulforaphane protected the liver against traumatic hemorrhagic shock through ameliorating the apoptosis and inflammation of the liver via activating the Nrf2/HO-1 pathway.	sulforaphane	12-24	heme oxygenase 1	Rattus norvegicus	170-174
34829573-0	2021	Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model.	sulforaphane	33-45	NFE2 like bZIP transcription factor 2	Rattus norvegicus	17-21
34583226-5	2021	We found that the phytochemical compounds, such as curcumin, naringenin, sulforaphane, diallyl disulfide, mangiferin, oleanolic acid, umbelliferone, daphnetin, quercetin, isorhamnetin-3-O-galactoside, hesperidin, diammonium glycyrrhizinate, corilagin, shikonin, farrerol, and chenpi, had the potential to improve the Nrf2-ARE signaling thereby combat hepatotoxicity.	sulforaphane	73-85	NFE2 like bZIP transcription factor 2	Homo sapiens	317-321
34829573-4	2021	Here, we aim to test the neuroprotective potential of a naturally occurring Nrf2 activator sulforaphane, in in vitro epileptiform activity model and a temporal lobe epilepsy rat model.	sulforaphane	91-103	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
34829573-6	2021	When given to rats after 2 h of kainic acid-induced status epilepticus, sulforaphane significantly increased the expression of Nrf2 and related antioxidant genes, improved oxidative stress markers, and increased the total antioxidant capacity in both the plasma and hippocampus.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	127-131
34320386-0	2021	Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the activation of Nrf-2/HO-1 signaling.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	96-101
34119834-3	2021	In the present work, a series of novel isothiocyanate-containing naphthalensulfonamides with the thioether, sulfoxide and sulfone moieties were designed by a structure-based molecular hybridization strategy using NXPZ-2 and the Nrf2 activator sulforaphane.	sulforaphane	243-255	NFE2 like bZIP transcription factor 2	Homo sapiens	228-232
34119834-7	2021	In an LPS-induced peritoneal macrophage cell model, this compound could cause a significant increase in the nuclear Nrf2 protein, decrease in the cytosolic Nrf2 protein, and further elevate the downstream protective enzymes HO-1 and NQO-1, which were better than the lead compound NXPZ-2 and sulforaphane.	sulforaphane	292-304	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
34119834-7	2021	In an LPS-induced peritoneal macrophage cell model, this compound could cause a significant increase in the nuclear Nrf2 protein, decrease in the cytosolic Nrf2 protein, and further elevate the downstream protective enzymes HO-1 and NQO-1, which were better than the lead compound NXPZ-2 and sulforaphane.	sulforaphane	292-304	NFE2 like bZIP transcription factor 2	Homo sapiens	156-160
34119834-7	2021	In an LPS-induced peritoneal macrophage cell model, this compound could cause a significant increase in the nuclear Nrf2 protein, decrease in the cytosolic Nrf2 protein, and further elevate the downstream protective enzymes HO-1 and NQO-1, which were better than the lead compound NXPZ-2 and sulforaphane.	sulforaphane	292-304	heme oxygenase 1	Homo sapiens	224-228
34119834-7	2021	In an LPS-induced peritoneal macrophage cell model, this compound could cause a significant increase in the nuclear Nrf2 protein, decrease in the cytosolic Nrf2 protein, and further elevate the downstream protective enzymes HO-1 and NQO-1, which were better than the lead compound NXPZ-2 and sulforaphane.	sulforaphane	292-304	NAD(P)H quinone dehydrogenase 1	Homo sapiens	233-238
34620841-0	2021	Sulforaphane downregulated fatty acid synthase and inhibited microtubule-mediated mitophagy leading to apoptosis.	sulforaphane	0-12	fatty acid synthase	Homo sapiens	27-46
34722615-0	2021	Role of the Aryl Hydrocarbon Receptor and Gut Microbiota-Derived Metabolites Indole-3-Acetic Acid in Sulforaphane Alleviates Hepatic Steatosis in Mice.	sulforaphane	101-113	aryl-hydrocarbon receptor	Mus musculus	12-37
34722615-3	2021	In this study, we aimed to investigate the role of indole-3-acetic acid (IAA) and AHR in sulforaphane (SFN) alleviates hepatic steatosis in mice fed on a high-fat diet (HFD).	sulforaphane	89-101	aryl-hydrocarbon receptor	Mus musculus	82-85
34722615-3	2021	In this study, we aimed to investigate the role of indole-3-acetic acid (IAA) and AHR in sulforaphane (SFN) alleviates hepatic steatosis in mice fed on a high-fat diet (HFD).	sulforaphane	103-106	aryl-hydrocarbon receptor	Mus musculus	82-85
34112534-9	2021	The activation of Nrf2 by Sulforaphane (SFP) could reverse the chemotherapeutic effect and changes of glycolysis of concomitant of Ara-C with Brusatol in AML cell lines.	sulforaphane	26-38	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
34112534-9	2021	The activation of Nrf2 by Sulforaphane (SFP) could reverse the chemotherapeutic effect and changes of glycolysis of concomitant of Ara-C with Brusatol in AML cell lines.	sulforaphane	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
34082215-11	2021	Conversely, sulforaphane, a Nrf2 inducer, ameliorated the pulmonary damage induced by DBP in the above.	sulforaphane	12-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	28-32
34320386-0	2021	Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the activation of Nrf-2/HO-1 signaling.	sulforaphane	0-12	heme oxygenase 1	Rattus norvegicus	102-106
34320386-8	2021	CONCLUSION: Sulforaphane can inhibit the inflammatory response and oxidative stress induced by HI/RI through promoting the activation of the Nrf-2 / HO-1 signal pathway.	sulforaphane	12-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	141-146
34320386-8	2021	CONCLUSION: Sulforaphane can inhibit the inflammatory response and oxidative stress induced by HI/RI through promoting the activation of the Nrf-2 / HO-1 signal pathway.	sulforaphane	12-24	heme oxygenase 1	Rattus norvegicus	149-153
34474895-1	2021	Sulforaphane (SFN) is an isothiocyanate with anti-arthritic and immuno-regulatory activities, supported by the downregulation of NF-kappaB pathway, reduction on metalloproteinases expression and prevention of cytokine-induced cartilage degeneration implicated in OA progression.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	129-138
34589134-10	2021	In addition, Western blotting revealed that the expressions of HER-2, p-HER-2, AKT, p-AKT, ERK, and p-ERK were downregulated by lapatinib-sulforaphane treatment.	sulforaphane	138-150	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-68
34589134-10	2021	In addition, Western blotting revealed that the expressions of HER-2, p-HER-2, AKT, p-AKT, ERK, and p-ERK were downregulated by lapatinib-sulforaphane treatment.	sulforaphane	138-150	erb-b2 receptor tyrosine kinase 2	Homo sapiens	72-77
34589134-10	2021	In addition, Western blotting revealed that the expressions of HER-2, p-HER-2, AKT, p-AKT, ERK, and p-ERK were downregulated by lapatinib-sulforaphane treatment.	sulforaphane	138-150	AKT serine/threonine kinase 1	Homo sapiens	79-82
34589134-10	2021	In addition, Western blotting revealed that the expressions of HER-2, p-HER-2, AKT, p-AKT, ERK, and p-ERK were downregulated by lapatinib-sulforaphane treatment.	sulforaphane	138-150	AKT serine/threonine kinase 1	Homo sapiens	86-89
34589134-10	2021	In addition, Western blotting revealed that the expressions of HER-2, p-HER-2, AKT, p-AKT, ERK, and p-ERK were downregulated by lapatinib-sulforaphane treatment.	sulforaphane	138-150	EPH receptor B2	Homo sapiens	91-94
34589134-10	2021	In addition, Western blotting revealed that the expressions of HER-2, p-HER-2, AKT, p-AKT, ERK, and p-ERK were downregulated by lapatinib-sulforaphane treatment.	sulforaphane	138-150	EPH receptor B2	Homo sapiens	102-105
34455814-7	2021	Cruciferous vegetables in general, and broccoli in particular, are rich in glucoraphanin, a precursor of sulforaphane that has been shown to have protective effects against oxidative damage through the activation of Nrf2.	sulforaphane	105-117	NFE2 like bZIP transcription factor 2	Homo sapiens	216-220
34474895-1	2021	Sulforaphane (SFN) is an isothiocyanate with anti-arthritic and immuno-regulatory activities, supported by the downregulation of NF-kappaB pathway, reduction on metalloproteinases expression and prevention of cytokine-induced cartilage degeneration implicated in OA progression.	sulforaphane	14-17	nuclear factor kappa B subunit 1	Homo sapiens	129-138
34441704-4	2021	The formation of sulforaphane is controlled by the epithiospecifier protein, a myrosinase co-factor, which is temperature-specific.	sulforaphane	17-29	myrosinase	Raphanus sativus	79-89
34502168-11	2021	In addition, the review explores possible new AhR-mediated mechanisms of several drugs used for treatment of ASD, such as sulforaphane, resveratrol, haloperidol, and metformin.	sulforaphane	122-134	aryl hydrocarbon receptor	Homo sapiens	46-49
34424425-0	2021	Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3.	sulforaphane	0-12	sonic hedgehog signaling molecule	Homo sapiens	87-101
34424425-0	2021	Sulforaphane inhibits self-renewal of lung cancer stem cells through the modulation of sonic Hedgehog signaling pathway and polyhomeotic homolog 3.	sulforaphane	0-12	polyhomeotic homolog 3	Homo sapiens	124-146
34153466-3	2021	Here, we demonstrated the beneficial effect of the phytochemical sulforaphane (SFN), exerted through NRF2-dependent and independent manner, on pathways relevant to brain function, bioenergetics, unfolded protein response, proteosome, antioxidant defenses, and iron metabolism in fibroblasts from FXTAS-affected subjects at all disease stages.	sulforaphane	65-77	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
34153466-3	2021	Here, we demonstrated the beneficial effect of the phytochemical sulforaphane (SFN), exerted through NRF2-dependent and independent manner, on pathways relevant to brain function, bioenergetics, unfolded protein response, proteosome, antioxidant defenses, and iron metabolism in fibroblasts from FXTAS-affected subjects at all disease stages.	sulforaphane	79-82	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
34362481-12	2021	At the same time, the protein level of P53 was significantly increased in KG1 and kG1a cells after treated by SFN(P<0.05).	sulforaphane	110-113	tumor protein p53	Homo sapiens	39-42
34443505-6	2021	Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24 cell growth since Nrf2 siRNA and GSH-depleting agent L-Buthionine-sulfoximine abolished the effect of SFN on cell proliferation.	sulforaphane	78-81	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
34443505-6	2021	Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24 cell growth since Nrf2 siRNA and GSH-depleting agent L-Buthionine-sulfoximine abolished the effect of SFN on cell proliferation.	sulforaphane	191-194	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34443505-6	2021	Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24 cell growth since Nrf2 siRNA and GSH-depleting agent L-Buthionine-sulfoximine abolished the effect of SFN on cell proliferation.	sulforaphane	191-194	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
34443505-7	2021	In summary, the inhibitory effect of SFN on bladder cancer cell growth and migration is highly dependent on Nrf2-mediated GSH depletion and following production.	sulforaphane	37-40	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
34411187-0	2021	Correction: The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines.	sulforaphane	41-53	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
34107274-8	2021	The Nrf2 agonist sulforaphane, which upregulated the transcriptional activity of the Nrf2-antioxidant response element (ARE) pathway, remarkably inhibited hepatocyte senescence and its activation effect on HSCs.	sulforaphane	17-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	4-8
34107274-8	2021	The Nrf2 agonist sulforaphane, which upregulated the transcriptional activity of the Nrf2-antioxidant response element (ARE) pathway, remarkably inhibited hepatocyte senescence and its activation effect on HSCs.	sulforaphane	17-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
34443505-0	2021	The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation.	sulforaphane	25-37	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
34443505-6	2021	Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24 cell growth since Nrf2 siRNA and GSH-depleting agent L-Buthionine-sulfoximine abolished the effect of SFN on cell proliferation.	sulforaphane	78-81	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34184072-0	2021	Sulforaphane protects against oxidative stress-induced apoptosis via activating SIRT1 in mouse osteoarthritis.	sulforaphane	0-12	sirtuin 1	Mus musculus	80-85
34184072-3	2021	Sulforaphane (SFN), a dietary isothiocyanate obtained from cruciferous vegetables, has been reported to exert an anti-apoptotic effect by activating sirtuin 1 (SIRT1).	sulforaphane	0-12	sirtuin 1	Mus musculus	149-158
34184072-3	2021	Sulforaphane (SFN), a dietary isothiocyanate obtained from cruciferous vegetables, has been reported to exert an anti-apoptotic effect by activating sirtuin 1 (SIRT1).	sulforaphane	0-12	sirtuin 1	Homo sapiens	160-165
34184072-3	2021	Sulforaphane (SFN), a dietary isothiocyanate obtained from cruciferous vegetables, has been reported to exert an anti-apoptotic effect by activating sirtuin 1 (SIRT1).	sulforaphane	14-17	sirtuin 1	Mus musculus	149-158
34184072-3	2021	Sulforaphane (SFN), a dietary isothiocyanate obtained from cruciferous vegetables, has been reported to exert an anti-apoptotic effect by activating sirtuin 1 (SIRT1).	sulforaphane	14-17	sirtuin 1	Homo sapiens	160-165
34316328-8	2021	Both H727 and H720 cells were associated with induction of apoptosis, upregulation of the p21 cell cycle inhibitor, and downregulation of the PI3K/Akt/mTOR pathway, suggesting that the PI3K/Akt/mTOR pathway is a primary target of the AZ+SFN combination therapy.	sulforaphane	237-240	AKT serine/threonine kinase 1	Homo sapiens	147-150
34316328-0	2021	Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis.	sulforaphane	62-74	AKT serine/threonine kinase 1	Homo sapiens	174-177
34316328-8	2021	Both H727 and H720 cells were associated with induction of apoptosis, upregulation of the p21 cell cycle inhibitor, and downregulation of the PI3K/Akt/mTOR pathway, suggesting that the PI3K/Akt/mTOR pathway is a primary target of the AZ+SFN combination therapy.	sulforaphane	237-240	mechanistic target of rapamycin kinase	Homo sapiens	151-155
34316328-0	2021	Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis.	sulforaphane	62-74	mechanistic target of rapamycin kinase	Homo sapiens	178-182
34316328-8	2021	Both H727 and H720 cells were associated with induction of apoptosis, upregulation of the p21 cell cycle inhibitor, and downregulation of the PI3K/Akt/mTOR pathway, suggesting that the PI3K/Akt/mTOR pathway is a primary target of the AZ+SFN combination therapy.	sulforaphane	237-240	AKT serine/threonine kinase 1	Homo sapiens	190-193
34316328-2	2021	The phytochemical and bioactive agent sulforaphane (SFN) has nutrigenomic potential in activating the expression of several cellular protective genes via the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	179-222
34316328-2	2021	The phytochemical and bioactive agent sulforaphane (SFN) has nutrigenomic potential in activating the expression of several cellular protective genes via the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).	sulforaphane	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
34316328-2	2021	The phytochemical and bioactive agent sulforaphane (SFN) has nutrigenomic potential in activating the expression of several cellular protective genes via the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	179-222
34316328-2	2021	The phytochemical and bioactive agent sulforaphane (SFN) has nutrigenomic potential in activating the expression of several cellular protective genes via the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2).	sulforaphane	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	224-228
34316328-8	2021	Both H727 and H720 cells were associated with induction of apoptosis, upregulation of the p21 cell cycle inhibitor, and downregulation of the PI3K/Akt/mTOR pathway, suggesting that the PI3K/Akt/mTOR pathway is a primary target of the AZ+SFN combination therapy.	sulforaphane	237-240	mechanistic target of rapamycin kinase	Homo sapiens	194-198
34316328-9	2021	CONCLUSIONS: Combining SFN+AZ significantly inhibits the PI3K/Akt/mTOR pathway and significantly reducing 5-HT secretion in carcinoid syndrome.	sulforaphane	23-26	AKT serine/threonine kinase 1	Homo sapiens	62-65
34316328-9	2021	CONCLUSIONS: Combining SFN+AZ significantly inhibits the PI3K/Akt/mTOR pathway and significantly reducing 5-HT secretion in carcinoid syndrome.	sulforaphane	23-26	mechanistic target of rapamycin kinase	Homo sapiens	66-70
34205320-9	2021	The expression of Nrf2 was decreased by CLDN2 knockdown, which was inhibited by fasentin and sulforaphane, a typical Nrf2 activator, in spheroid cells.	sulforaphane	93-105	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
34282380-0	2021	Inhibition of TGF-beta2-induced migration and epithelial-mesenchymal transition in ARPE-19 by sulforaphane.	sulforaphane	94-106	transforming growth factor beta 2	Homo sapiens	14-23
34282380-1	2021	AIM: To investigate the effects of sulforaphane (SFN) on transforming growth factor (TGF)-beta2 stimulated migration and epithelial-mesenchymal transition (EMT) in ARPE-19 cells.	sulforaphane	35-47	transforming growth factor beta 2	Homo sapiens	57-95
34282380-1	2021	AIM: To investigate the effects of sulforaphane (SFN) on transforming growth factor (TGF)-beta2 stimulated migration and epithelial-mesenchymal transition (EMT) in ARPE-19 cells.	sulforaphane	49-52	transforming growth factor beta 2	Homo sapiens	57-95
34272506-0	2022	Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription.	sulforaphane	0-12	brain derived neurotrophic factor	Mus musculus	97-101
34272506-1	2022	Sulforaphane (SFN) is an organic isothiocyanate and an NF-E2-related factor-2 (Nrf2) inducer that exerts prophylactic effects on depression-like behavior in mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-77
34272506-1	2022	Sulforaphane (SFN) is an organic isothiocyanate and an NF-E2-related factor-2 (Nrf2) inducer that exerts prophylactic effects on depression-like behavior in mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
34272506-1	2022	Sulforaphane (SFN) is an organic isothiocyanate and an NF-E2-related factor-2 (Nrf2) inducer that exerts prophylactic effects on depression-like behavior in mice.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-77
34272506-1	2022	Sulforaphane (SFN) is an organic isothiocyanate and an NF-E2-related factor-2 (Nrf2) inducer that exerts prophylactic effects on depression-like behavior in mice.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
34202008-2	2021	As sulforaphane N-acetylcysteine (SFN-NAC), a major sulforaphane metabolite, has presented similar pharmacological activities to those of SFN, it is crucial to simultaneously analyze the pharmacokinetics and activities of SFN and SFN-NAC, to comprehensively elucidate the efficacy of SFN-containing products.	sulforaphane	3-15	synuclein alpha	Homo sapiens	38-41
34202008-2	2021	As sulforaphane N-acetylcysteine (SFN-NAC), a major sulforaphane metabolite, has presented similar pharmacological activities to those of SFN, it is crucial to simultaneously analyze the pharmacokinetics and activities of SFN and SFN-NAC, to comprehensively elucidate the efficacy of SFN-containing products.	sulforaphane	52-64	synuclein alpha	Homo sapiens	38-41
34202008-8	2021	Although the plasma SFN-NAC concentration was low owing to poor absorption following oral administration, SFN-NAC was converted to SFN in vivo, as in plasma.	sulforaphane	131-134	synuclein alpha	Homo sapiens	110-113
34205320-10	2021	The sensitivity of spheroid cells to doxorubicin, an anthracycline antitumor antibiotic, was enhanced by CLDN2 knockdown, which was inhibited by fasentin and sulforaphane.	sulforaphane	158-170	claudin 2	Homo sapiens	105-110
34205320-9	2021	The expression of Nrf2 was decreased by CLDN2 knockdown, which was inhibited by fasentin and sulforaphane, a typical Nrf2 activator, in spheroid cells.	sulforaphane	93-105	claudin 2	Homo sapiens	40-45
34205320-9	2021	The expression of Nrf2 was decreased by CLDN2 knockdown, which was inhibited by fasentin and sulforaphane, a typical Nrf2 activator, in spheroid cells.	sulforaphane	93-105	NFE2 like bZIP transcription factor 2	Homo sapiens	117-121
34206048-2	2021	To investigate the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in acrylamide-induced neuropathy, male C57Bl/6JJcl adult mice were exposed to acrylamide at 0, 200 or 300 ppm in drinking water and co-administered with subcutaneous injections of sulforaphane, a known activator of the Nrf2 signaling pathway at 0 or 25 mg/kg body weight daily for 4 weeks.	sulforaphane	258-270	nuclear factor, erythroid derived 2, like 2	Mus musculus	297-301
34222291-10	2021	PM2.5 treatment decreased the enzymatic activities of the antioxidant enzymes including superoxide dismutase and catalase, which were restored by SFN treatment.	sulforaphane	146-149	catalase	Homo sapiens	113-121
34200377-6	2021	Pharmacological activation of Nrf2 with SFN abrogated Aldo-induced vascular dysfunction and ROS generation.	sulforaphane	40-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	sulforaphane	31-43	nitric oxide synthase 2, inducible	Mus musculus	237-268
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	sulforaphane	31-43	nitric oxide synthase 2, inducible	Mus musculus	270-274
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	sulforaphane	31-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
34206048-6	2021	The results demonstrate that activation of the Nrf2 signaling pathway by co-treatment of sulforaphane provides protection against acrylamide-induced neurotoxicity through suppression of oxidative stress and inflammation.	sulforaphane	89-101	nuclear factor, erythroid derived 2, like 2	Mus musculus	47-51
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	sulforaphane	31-43	tumor necrosis factor	Mus musculus	193-220
34206048-5	2021	Moreover, co-administration of sulforaphane enhanced acrylamide-induced mRNA upregulation of Nrf2 and its downstream antioxidant proteins and suppressed acrylamide-induced mRNA upregulation of tumor necrosis factor alpha (TNF-alpha) and inducible nitric oxide synthase (iNOS) in the cerebral cortex.	sulforaphane	31-43	tumor necrosis factor	Mus musculus	222-231
34072812-6	2021	SFN treatment also induced DNA demethylation in the promoter region of the MHC-SLA1 gene, resulting in the upregulation of Toll-like receptor 4 (TLR4), MHC-SLA1, and inflammatory cytokines" expression at 6 h of LPS stimulation.	sulforaphane	0-3	major histocompatibility complex, class I, C	Homo sapiens	152-155
34072812-0	2021	Epigenetic Modulation of TLR4 Expression by Sulforaphane Increases Anti-Inflammatory Capacity in Porcine Monocyte-Derived Dendritic Cells.	sulforaphane	44-56	toll like receptor 4	Homo sapiens	25-29
34072812-6	2021	SFN treatment also induced DNA demethylation in the promoter region of the MHC-SLA1 gene, resulting in the upregulation of Toll-like receptor 4 (TLR4), MHC-SLA1, and inflammatory cytokines" expression at 6 h of LPS stimulation.	sulforaphane	0-3	Src like adaptor	Homo sapiens	156-160
34072812-6	2021	SFN treatment also induced DNA demethylation in the promoter region of the MHC-SLA1 gene, resulting in the upregulation of Toll-like receptor 4 (TLR4), MHC-SLA1, and inflammatory cytokines" expression at 6 h of LPS stimulation.	sulforaphane	0-3	major histocompatibility complex, class I, C	Homo sapiens	75-78
35616153-0	2022	(Corrigendum) Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT-1.	sulforaphane	14-26	FAT atypical cadherin 1	Homo sapiens	151-156
34072812-6	2021	SFN treatment also induced DNA demethylation in the promoter region of the MHC-SLA1 gene, resulting in the upregulation of Toll-like receptor 4 (TLR4), MHC-SLA1, and inflammatory cytokines" expression at 6 h of LPS stimulation.	sulforaphane	0-3	Src like adaptor	Homo sapiens	79-83
34072812-6	2021	SFN treatment also induced DNA demethylation in the promoter region of the MHC-SLA1 gene, resulting in the upregulation of Toll-like receptor 4 (TLR4), MHC-SLA1, and inflammatory cytokines" expression at 6 h of LPS stimulation.	sulforaphane	0-3	toll like receptor 4	Homo sapiens	123-143
34072812-6	2021	SFN treatment also induced DNA demethylation in the promoter region of the MHC-SLA1 gene, resulting in the upregulation of Toll-like receptor 4 (TLR4), MHC-SLA1, and inflammatory cytokines" expression at 6 h of LPS stimulation.	sulforaphane	0-3	toll like receptor 4	Homo sapiens	145-149
35512617-10	2022	The NRF2-activator sulforaphane is a potential chemo-preventive agent for oral cancer.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
34094831-0	2021	Inhibiting autophagy enhances sulforaphane-induced apoptosis via targeting NRF2 in esophageal squamous cell carcinoma.	sulforaphane	30-42	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
34077026-0	2021	Sulforaphane exerts anticancer effects on human liver cancer cells via induction of apoptosis and inhibition of migration and invasion by targeting MAPK7 signalling pathway.	sulforaphane	0-12	mitogen-activated protein kinase 7	Homo sapiens	148-153
34077026-1	2021	Retraction of: "Sulforaphane exerts anticancer effects on human liver cancer cells via induction of apoptosis and inhibition of migration and invasion by targeting MAPK7 signalling pathway", by Bo Huang, Shixiong Lei, Dong Wang, Yibo Sun, Jikai Yin JBUON 2019;25(2):959-964; PMID:32521892.	sulforaphane	16-28	mitogen-activated protein kinase 7	Homo sapiens	164-169
35461903-0	2022	Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes.	sulforaphane	0-12	mechanistic target of rapamycin kinase	Mus musculus	62-66
35461903-0	2022	Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes.	sulforaphane	0-12	unc-51 like kinase 1	Mus musculus	67-71
35461903-2	2022	The chemotherapeutic isothiocyanate sulforaphane (SFN) contributes to lipolysis through the activation of hormone-sensitive lipase and the browning of white adipocytes.	sulforaphane	50-53	lipase, hormone sensitive	Mus musculus	106-130
35461903-7	2022	Immunofluorescence showed that the SFN-induced LC3 expression was co-localized with LDs in 3T3-L1 adipocytes and with perilipin, the most abundant adipocyte-specific protein, in adipocytes of mice fed an HFD.	sulforaphane	35-38	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	47-50
35461903-10	2022	ATG5 knockdown partially blocked the SFN-induced release of fatty acids from LDs in mature 3T3-L1 adipocytes.	sulforaphane	37-40	autophagy related 5	Mus musculus	0-4
35512617-2	2022	DESIGN: The BRCA1 gene was silenced in CAL-27 and DOK cells using specific shRNA, and NRF2 was activated with sulforaphane.	sulforaphane	110-122	BRCA1 DNA repair associated	Homo sapiens	12-17
35512617-2	2022	DESIGN: The BRCA1 gene was silenced in CAL-27 and DOK cells using specific shRNA, and NRF2 was activated with sulforaphane.	sulforaphane	110-122	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
35512617-7	2022	Activation of NRF2 by sulforaphane significantly upregulated NRF2 levels in the BRCA1-depleted cells, and restored proliferation, apoptosis and 8-OXo-2"-deoxyguanosine level in a dose-dependent manner.	sulforaphane	22-34	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
35512617-7	2022	Activation of NRF2 by sulforaphane significantly upregulated NRF2 levels in the BRCA1-depleted cells, and restored proliferation, apoptosis and 8-OXo-2"-deoxyguanosine level in a dose-dependent manner.	sulforaphane	22-34	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
35512617-7	2022	Activation of NRF2 by sulforaphane significantly upregulated NRF2 levels in the BRCA1-depleted cells, and restored proliferation, apoptosis and 8-OXo-2"-deoxyguanosine level in a dose-dependent manner.	sulforaphane	22-34	BRCA1 DNA repair associated	Homo sapiens	80-85
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	mitogen-activated protein kinase 14	Mus musculus	166-174
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor 21	Mus musculus	194-199
34654875-0	2022	Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway.	sulforaphane	0-12	fibroblast growth factor 21	Mus musculus	80-85
35157168-2	2022	We recently demonstrated that sulforaphane (SFN) protected mice from developing pulmonary arterial hypertension (PAH) and right ventricular (RV) dysfunction by elevating cardiac Nrf2 expression and function.	sulforaphane	30-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
34654875-0	2022	Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway.	sulforaphane	0-12	fibroblast growth factor receptor 1	Mus musculus	86-91
34654875-1	2022	Most studies regarding the beneficial effect of sulforaphane (SFN) on non-alcoholic fatty liver disease (NAFLD) have focused on nuclear factor E2-related factor 2 (Nrf2).	sulforaphane	48-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-162
34654875-1	2022	Most studies regarding the beneficial effect of sulforaphane (SFN) on non-alcoholic fatty liver disease (NAFLD) have focused on nuclear factor E2-related factor 2 (Nrf2).	sulforaphane	48-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	164-168
34654875-1	2022	Most studies regarding the beneficial effect of sulforaphane (SFN) on non-alcoholic fatty liver disease (NAFLD) have focused on nuclear factor E2-related factor 2 (Nrf2).	sulforaphane	62-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-162
34654875-1	2022	Most studies regarding the beneficial effect of sulforaphane (SFN) on non-alcoholic fatty liver disease (NAFLD) have focused on nuclear factor E2-related factor 2 (Nrf2).	sulforaphane	62-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	164-168
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor receptor 1	Mus musculus	65-70
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor 21	Mus musculus	75-102
34654875-7	2022	SFN administration significantly increased hepatic expression of FGFR1 and fibroblast growth factor 21 (FGF21) in NAFLD mice, along with decreased phosphorylation of p38 MAPK (the downstream of FGF21).	sulforaphane	0-3	fibroblast growth factor 21	Mus musculus	104-109
35157168-2	2022	We recently demonstrated that sulforaphane (SFN) protected mice from developing pulmonary arterial hypertension (PAH) and right ventricular (RV) dysfunction by elevating cardiac Nrf2 expression and function.	sulforaphane	44-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
35271969-2	2022	PA and LPS may contribute to SI observed in obesity, while the dietary antioxidant sulforaphane has been shown to reduce activation of the NLRP3 inflammasome.	sulforaphane	83-95	NLR family pyrin domain containing 3	Homo sapiens	139-144
35271969-3	2022	This study investigated immune cell responses from obese subjects to PA, and the effects of sulforaphane on NLRP3 activation/inflammation.	sulforaphane	92-104	NLR family pyrin domain containing 3	Homo sapiens	108-113
35271969-8	2022	Sulforaphane reduced TNF-alpha and IL-1beta from monocytes in both groups, however inflammasome associated genes were only reduced in monocytes from obese subjects.	sulforaphane	0-12	tumor necrosis factor	Homo sapiens	21-30
35271969-8	2022	Sulforaphane reduced TNF-alpha and IL-1beta from monocytes in both groups, however inflammasome associated genes were only reduced in monocytes from obese subjects.	sulforaphane	0-12	interleukin 1 alpha	Homo sapiens	35-43
35609851-0	2022	DeltaNp63alpha mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2.	sulforaphane	24-36	Nanog homeobox	Homo sapiens	125-130
35316762-0	2022	Sulforaphane protects myocardium from ischemia-reperfusion injury by regulating CaMKIIN2 and CaMKIIdelta.	sulforaphane	0-12	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	93-104
35610278-2	2022	In this study, we describe that naturally occurring isothiocyanate sulforaphane (SFaN) impairs fatty acid synthase promoter activity and reduces SREBP target gene (e.g., fatty acid synthase and acetyl-CoA carboxylase 1) expression in human hepatoma Huh-7 cells.	sulforaphane	81-85	fatty acid synthase	Homo sapiens	95-114
35610278-2	2022	In this study, we describe that naturally occurring isothiocyanate sulforaphane (SFaN) impairs fatty acid synthase promoter activity and reduces SREBP target gene (e.g., fatty acid synthase and acetyl-CoA carboxylase 1) expression in human hepatoma Huh-7 cells.	sulforaphane	81-85	fatty acid synthase	Homo sapiens	170-189
35610278-2	2022	In this study, we describe that naturally occurring isothiocyanate sulforaphane (SFaN) impairs fatty acid synthase promoter activity and reduces SREBP target gene (e.g., fatty acid synthase and acetyl-CoA carboxylase 1) expression in human hepatoma Huh-7 cells.	sulforaphane	81-85	acetyl-CoA carboxylase alpha	Homo sapiens	194-218
35609851-0	2022	DeltaNp63alpha mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2.	sulforaphane	24-36	POU class 5 homeobox 1	Homo sapiens	131-135
35609851-0	2022	DeltaNp63alpha mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2.	sulforaphane	24-36	SRY-box transcription factor 2	Homo sapiens	136-140
35600947-0	2022	Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
35595779-5	2022	Repeated administration of sulforaphane (SFN, an Nrf2 activator) attenuated dopaminergic neurotoxicity in MPTP-treated mice through activation of BDNF and suppression of MeCP2 expression.	sulforaphane	27-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
35595779-5	2022	Repeated administration of sulforaphane (SFN, an Nrf2 activator) attenuated dopaminergic neurotoxicity in MPTP-treated mice through activation of BDNF and suppression of MeCP2 expression.	sulforaphane	27-39	brain derived neurotrophic factor	Mus musculus	146-150
35595779-5	2022	Repeated administration of sulforaphane (SFN, an Nrf2 activator) attenuated dopaminergic neurotoxicity in MPTP-treated mice through activation of BDNF and suppression of MeCP2 expression.	sulforaphane	27-39	methyl CpG binding protein 2	Mus musculus	170-175
35595779-5	2022	Repeated administration of sulforaphane (SFN, an Nrf2 activator) attenuated dopaminergic neurotoxicity in MPTP-treated mice through activation of BDNF and suppression of MeCP2 expression.	sulforaphane	41-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
35595779-5	2022	Repeated administration of sulforaphane (SFN, an Nrf2 activator) attenuated dopaminergic neurotoxicity in MPTP-treated mice through activation of BDNF and suppression of MeCP2 expression.	sulforaphane	41-44	brain derived neurotrophic factor	Mus musculus	146-150
35595779-5	2022	Repeated administration of sulforaphane (SFN, an Nrf2 activator) attenuated dopaminergic neurotoxicity in MPTP-treated mice through activation of BDNF and suppression of MeCP2 expression.	sulforaphane	41-44	methyl CpG binding protein 2	Mus musculus	170-175
35184385-8	2022	Additionally, the effect of VDR activation on CYP3A4 mRNA expression was abolished by natural dietary compound sulforaphane, a common suppressor of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	sulforaphane	111-123	vitamin D receptor	Homo sapiens	28-31
35563563-0	2022	Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-kappaB Signaling in Human Gastric Cancer Cells.	sulforaphane	0-12	matrix metallopeptidase 9	Homo sapiens	63-89
35563563-0	2022	Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-kappaB Signaling in Human Gastric Cancer Cells.	sulforaphane	0-12	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	118-122
35563563-0	2022	Sulforaphane Suppresses the Nicotine-Induced Expression of the Matrix Metalloproteinase-9 via Inhibiting ROS-Mediated AP-1 and NF-kappaB Signaling in Human Gastric Cancer Cells.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	127-136
35600210-0	2022	Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3beta Signaling Pathway.	sulforaphane	0-12	thymoma viral proto-oncogene 1	Mus musculus	99-102
35600210-0	2022	Sulforaphane Ameliorates the Intestinal Injury in Necrotizing Enterocolitis by Regulating the PI3K/Akt/GSK-3beta Signaling Pathway.	sulforaphane	0-12	glycogen synthase kinase 3 alpha	Mus musculus	103-112
35563563-3	2022	However, the role of sulforaphane in MMP-9 expression in gastric cancer is not yet defined.	sulforaphane	21-33	matrix metallopeptidase 9	Homo sapiens	37-42
35563563-5	2022	Here, we found that sulforaphane suppresses the nicotine-mediated induction of MMP-9 in human gastric cancer cells.	sulforaphane	20-32	matrix metallopeptidase 9	Homo sapiens	79-84
35563563-9	2022	Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-kappaB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells.	sulforaphane	0-12	matrix metallopeptidase 9	Homo sapiens	45-50
35563563-9	2022	Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-kappaB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells.	sulforaphane	0-12	mitogen-activated protein kinase 3	Homo sapiens	94-100
35563563-9	2022	Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-kappaB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells.	sulforaphane	0-12	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	102-106
35563563-9	2022	Sulforaphane suppresses the nicotine-induced MMP-9 by inhibiting ROS-mediated MAPK (p38 MAPK, Erk1/2)/AP-1 and ROS-mediated NF-kappaB signaling axes, which in turn inhibit cell invasion in human gastric cancer AGS cells.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	124-133
35303531-4	2022	Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.	sulforaphane	0-12	NLR family pyrin domain containing 3	Homo sapiens	47-52
35303531-4	2022	Sulforaphane mediates the inhibitory effect on NLRP3 inflammasome activation and we believe that this could be the main mechanism where sulforaphane is useful for patients with COVID-19.	sulforaphane	136-148	NLR family pyrin domain containing 3	Homo sapiens	47-52
35184385-8	2022	Additionally, the effect of VDR activation on CYP3A4 mRNA expression was abolished by natural dietary compound sulforaphane, a common suppressor of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	sulforaphane	111-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	46-52
35184385-8	2022	Additionally, the effect of VDR activation on CYP3A4 mRNA expression was abolished by natural dietary compound sulforaphane, a common suppressor of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	sulforaphane	111-123	nuclear receptor subfamily 1 group I member 2	Homo sapiens	148-167
35184385-8	2022	Additionally, the effect of VDR activation on CYP3A4 mRNA expression was abolished by natural dietary compound sulforaphane, a common suppressor of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	sulforaphane	111-123	nuclear receptor subfamily 1 group I member 2	Homo sapiens	169-172
35184385-8	2022	Additionally, the effect of VDR activation on CYP3A4 mRNA expression was abolished by natural dietary compound sulforaphane, a common suppressor of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	sulforaphane	111-123	nuclear receptor subfamily 1 group I member 3	Homo sapiens	178-210
35184385-8	2022	Additionally, the effect of VDR activation on CYP3A4 mRNA expression was abolished by natural dietary compound sulforaphane, a common suppressor of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).	sulforaphane	111-123	nuclear receptor subfamily 1 group I member 3	Homo sapiens	212-215
35388300-9	2022	Codonopsis pilosula could upregulate HMOX1 via luteolin, capsaicin, and sulforaphane.	sulforaphane	72-84	heme oxygenase 1	Homo sapiens	37-42
35041848-3	2022	Accumulating evidence suggest that signaling between Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays an important role in the pathogenesis and treatment of brain dysfunction, while sulforaphane (SFN), a natural compound acting as an Nrf2 agonist, can improve brain function.	sulforaphane	289-301	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-195
35041848-3	2022	Accumulating evidence suggest that signaling between Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays an important role in the pathogenesis and treatment of brain dysfunction, while sulforaphane (SFN), a natural compound acting as an Nrf2 agonist, can improve brain function.	sulforaphane	289-301	NFE2 like bZIP transcription factor 2	Homo sapiens	197-201
35041848-3	2022	Accumulating evidence suggest that signaling between Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays an important role in the pathogenesis and treatment of brain dysfunction, while sulforaphane (SFN), a natural compound acting as an Nrf2 agonist, can improve brain function.	sulforaphane	289-301	NFE2 like bZIP transcription factor 2	Homo sapiens	341-345
35041848-7	2022	Interestingly, both pretreatment and posttreatment with SFN significantly improved the abnormal behaviors of mice in the MWMT, in parallel with the up-regulated levels of Keap1-Nrf2 signaling in the mPFC, hippocampus and liver.	sulforaphane	56-59	kelch-like ECH-associated protein 1	Mus musculus	171-176
35041848-7	2022	Interestingly, both pretreatment and posttreatment with SFN significantly improved the abnormal behaviors of mice in the MWMT, in parallel with the up-regulated levels of Keap1-Nrf2 signaling in the mPFC, hippocampus and liver.	sulforaphane	56-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	177-181
35422807-11	2022	The increases in miRNA-21 and miR-690 (observed using miRNA microarray) were further validated by RT-PCR, and the TCE-mediated increases in miR-21 and miR-690 were ameliorated by SFN treatment.	sulforaphane	179-182	microRNA 690	Mus musculus	30-37
35422807-11	2022	The increases in miRNA-21 and miR-690 (observed using miRNA microarray) were further validated by RT-PCR, and the TCE-mediated increases in miR-21 and miR-690 were ameliorated by SFN treatment.	sulforaphane	179-182	microRNA 21a	Mus musculus	140-146
35422807-11	2022	The increases in miRNA-21 and miR-690 (observed using miRNA microarray) were further validated by RT-PCR, and the TCE-mediated increases in miR-21 and miR-690 were ameliorated by SFN treatment.	sulforaphane	179-182	microRNA 690	Mus musculus	151-158
35563167-8	2022	Many agents, including lipoic acid, melatonin, thymoquinone, astaxanthin, and crucifera-derived sulforaphane, can promote Nrf2 activity.	sulforaphane	96-108	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
35469083-0	2022	The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1.	sulforaphane	19-31	heme oxygenase 1	Mus musculus	170-186
35469083-11	2022	Inhibition of heme oxygenase-1 (HO-1) suppressed the mitochondrial protection and anti-inflammatory action afforded by SFN in this experimental model.	sulforaphane	119-122	heme oxygenase 1	Mus musculus	14-30
35469083-11	2022	Inhibition of heme oxygenase-1 (HO-1) suppressed the mitochondrial protection and anti-inflammatory action afforded by SFN in this experimental model.	sulforaphane	119-122	heme oxygenase 1	Mus musculus	32-36
35397612-9	2022	Furthermore, sulforaphane (SFN) pre-treatment attenuated the FFA-induced oxidative stress by activating NFE2L2-mediated autophagy.	sulforaphane	13-25	NFE2 like bZIP transcription factor 2	Bos taurus	104-110
35397612-9	2022	Furthermore, sulforaphane (SFN) pre-treatment attenuated the FFA-induced oxidative stress by activating NFE2L2-mediated autophagy.	sulforaphane	27-30	NFE2 like bZIP transcription factor 2	Bos taurus	104-110
35441581-0	2022	Sulforaphane alleviates hypoxic vestibular vertigo (HVV) by increasing NO production via upregulating the expression of NRF2.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
35441581-1	2022	Sulforaphane (SFP) treatment represses oxidative stress by activating NRF2.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-74
35441581-1	2022	Sulforaphane (SFP) treatment represses oxidative stress by activating NRF2.	sulforaphane	14-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	70-74
35441581-7	2022	SFP treatment helped to maintain the escape latency and MDA, GSH, SOD concentrations in the brain of HVV rats, and recovered the expression of NRF2 inhibited in the brain of HVV rats.	sulforaphane	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
35041848-3	2022	Accumulating evidence suggest that signaling between Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays an important role in the pathogenesis and treatment of brain dysfunction, while sulforaphane (SFN), a natural compound acting as an Nrf2 agonist, can improve brain function.	sulforaphane	289-301	kelch like ECH associated protein 1	Homo sapiens	141-146
35323110-0	2022	Sulforaphane reduces obesity by reversing leptin resistance.	sulforaphane	0-12	leptin	Mus musculus	42-48
35323110-6	2022	Leptin-deficient Lepob/ob mice and leptin receptor mutant Leprdb/db mice display resistance to the weight-reducing effect of sulforaphane, supporting the conclusion that the antiobesity effect of sulforaphane requires functional leptin receptor signaling.	sulforaphane	196-208	leptin receptor	Mus musculus	229-244
35323110-4	2022	Here, we show that the natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia.	sulforaphane	72-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
35323110-7	2022	Furthermore, our results suggest the skeletal muscle as the most notable site of action of sulforaphane whose peripheral NRF2 action signals to alleviate leptin resistance.	sulforaphane	91-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
35323110-7	2022	Furthermore, our results suggest the skeletal muscle as the most notable site of action of sulforaphane whose peripheral NRF2 action signals to alleviate leptin resistance.	sulforaphane	91-103	leptin	Mus musculus	154-160
35323110-4	2022	Here, we show that the natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia.	sulforaphane	72-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	161-165
35323110-4	2022	Here, we show that the natural isothiocyanate and potent NRF2 activator sulforaphane reverses diet-induced obesity through a predominantly, but not exclusively, NRF2-dependent mechanism that requires a functional leptin receptor signaling and hyperleptinemia.	sulforaphane	72-84	leptin receptor	Mus musculus	213-228
35323110-5	2022	Sulforaphane does not reduce the body weight or food intake of lean mice but induces an anorectic response when coadministered with exogenous leptin.	sulforaphane	0-12	leptin	Mus musculus	142-148
35325302-5	2022	Since the genetic signature of microglia offers many potential targets for drug discovery, molecular docking followed by molecular dynamics (MD) simulations of cluster of differentiation 40 ligand (CD40L) and colony-stimulating factor 1 receptor (CSF1R) kinase domain protein with some known neuro-immunomodulators (Curcumin, Cannabidiol, Ginsenoside Rg1, Resveratrol, and Sulforaphane) has been evaluated.	sulforaphane	373-385	CD40 ligand	Homo sapiens	198-203
35325302-5	2022	Since the genetic signature of microglia offers many potential targets for drug discovery, molecular docking followed by molecular dynamics (MD) simulations of cluster of differentiation 40 ligand (CD40L) and colony-stimulating factor 1 receptor (CSF1R) kinase domain protein with some known neuro-immunomodulators (Curcumin, Cannabidiol, Ginsenoside Rg1, Resveratrol, and Sulforaphane) has been evaluated.	sulforaphane	373-385	colony stimulating factor 1 receptor	Homo sapiens	209-245
35157913-0	2022	Sulforaphane regulates the proliferation of leukemia stem-like cells via Sonic Hedgehog signaling pathway.	sulforaphane	0-12	sonic hedgehog signaling molecule	Homo sapiens	73-87
35401114-0	2022	Sulforaphane Attenuates Chronic Intermittent Hypoxia-Induced Brain Damage in Mice via Augmenting Nrf2 Nuclear Translocation and Autophagy.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
35401114-2	2022	Sulforaphane (SFN), an activator of nuclear factor E2-related factor 2 (Nrf2), has been demonstrated to protect against oxidative stress in various diseases.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-70
35401114-2	2022	Sulforaphane (SFN), an activator of nuclear factor E2-related factor 2 (Nrf2), has been demonstrated to protect against oxidative stress in various diseases.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
35401114-2	2022	Sulforaphane (SFN), an activator of nuclear factor E2-related factor 2 (Nrf2), has been demonstrated to protect against oxidative stress in various diseases.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-70
35401114-2	2022	Sulforaphane (SFN), an activator of nuclear factor E2-related factor 2 (Nrf2), has been demonstrated to protect against oxidative stress in various diseases.	sulforaphane	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
35327653-4	2022	Here, we found that NRF2 activation by sulforaphane (SFN) reduced cisplatin (CDDP)-induced cell death only in NRF2-proficient cells (NRF2-ctr) compared to NRF2-Cas9 cells.	sulforaphane	39-51	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
35327653-4	2022	Here, we found that NRF2 activation by sulforaphane (SFN) reduced cisplatin (CDDP)-induced cell death only in NRF2-proficient cells (NRF2-ctr) compared to NRF2-Cas9 cells.	sulforaphane	53-56	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
35038457-0	2022	Sulforaphane inhibits cytokine-stimulated chemokine and adhesion molecule expressions in human corneal fibroblasts: Involvement of the MAPK, STAT, and NF-kappaB signaling pathways.	sulforaphane	0-12	nuclear factor kappa B subunit 1	Homo sapiens	151-160
34984918-8	2022	Young cells were induced to express the senescence and pro-fibrotic phenotype by sulfasalazine, an Slc7a11 inhibitor, whereas treatment of old cells with sulforaphane, an Slc7a11 inducer, decreased senescence without affecting pro-fibrotic genes.	sulforaphane	154-166	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	99-106
34984918-8	2022	Young cells were induced to express the senescence and pro-fibrotic phenotype by sulfasalazine, an Slc7a11 inhibitor, whereas treatment of old cells with sulforaphane, an Slc7a11 inducer, decreased senescence without affecting pro-fibrotic genes.	sulforaphane	154-166	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	171-178
35370554-3	2022	To influence these changes, organic isothiocyanate compound sulforaphane (SFN) has been used in the present study for its known effect of enhancing antioxidative, cytoprotective, and metabolic cellular properties via the Nrf2 pathway.	sulforaphane	60-72	NFE2 like bZIP transcription factor 2	Homo sapiens	221-225
35370554-3	2022	To influence these changes, organic isothiocyanate compound sulforaphane (SFN) has been used in the present study for its known effect of enhancing antioxidative, cytoprotective, and metabolic cellular properties via the Nrf2 pathway.	sulforaphane	74-77	NFE2 like bZIP transcription factor 2	Homo sapiens	221-225
35370554-10	2022	We have demonstrated that the Nrf2 pathway is upregulated in the CNS of immature rats after SFN treatment.	sulforaphane	92-95	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
35179529-0	2022	Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics.	sulforaphane	19-31	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
35179529-5	2022	Under hypoxia, the expression of Nrf2 and heme oxygenase-1 was up-regulated by SFN treatment.	sulforaphane	79-82	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
35179529-5	2022	Under hypoxia, the expression of Nrf2 and heme oxygenase-1 was up-regulated by SFN treatment.	sulforaphane	79-82	heme oxygenase 1	Homo sapiens	42-58
35209084-0	2022	Treatment of Human Glioblastoma U251 Cells with Sulforaphane and a Peptide Nucleic Acid (PNA) Targeting miR-15b-5p: Synergistic Effects on Induction of Apoptosis.	sulforaphane	48-60	microRNA 15b	Homo sapiens	104-111
35256941-0	2022	Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways.	sulforaphane	73-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
35222401-0	2022	Sulforaphane Exerts Beneficial Immunomodulatory Effects on Liver Tissue via a Nrf2 Pathway-Related Mechanism in a Murine Model of Hemorrhagic Shock and Resuscitation.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
35222401-1	2022	Our research explores the immunomodulatory effects of sulforaphane (SFN), a well-known nuclear factor erythroid 2-related factor 2 (Nrf2) pathway agonist, on the sterile inflammation of and ischemia-reperfusion injuries to the liver after hemorrhagic shock (HS) followed by resuscitation (R).	sulforaphane	54-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-130
35222401-1	2022	Our research explores the immunomodulatory effects of sulforaphane (SFN), a well-known nuclear factor erythroid 2-related factor 2 (Nrf2) pathway agonist, on the sterile inflammation of and ischemia-reperfusion injuries to the liver after hemorrhagic shock (HS) followed by resuscitation (R).	sulforaphane	54-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	132-136
35222401-1	2022	Our research explores the immunomodulatory effects of sulforaphane (SFN), a well-known nuclear factor erythroid 2-related factor 2 (Nrf2) pathway agonist, on the sterile inflammation of and ischemia-reperfusion injuries to the liver after hemorrhagic shock (HS) followed by resuscitation (R).	sulforaphane	68-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-130
35222401-1	2022	Our research explores the immunomodulatory effects of sulforaphane (SFN), a well-known nuclear factor erythroid 2-related factor 2 (Nrf2) pathway agonist, on the sterile inflammation of and ischemia-reperfusion injuries to the liver after hemorrhagic shock (HS) followed by resuscitation (R).	sulforaphane	68-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	132-136
35216054-6	2022	Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-alpha, IL-1beta and IL-6, was observed.	sulforaphane	45-57	tumor necrosis factor	Homo sapiens	184-193
35216054-6	2022	Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-alpha, IL-1beta and IL-6, was observed.	sulforaphane	45-57	interleukin 1 alpha	Homo sapiens	195-203
35216054-6	2022	Furthermore, the anti-inflammatory action of sulforaphane-loaded membrane vesicles was demonstrated, as a decrease in interleukins crucial for the development of inflammation, such as TNF-alpha, IL-1beta and IL-6, was observed.	sulforaphane	45-57	interleukin 6	Homo sapiens	208-212
35256941-7	2022	Nuclear factor erythroid 2-related factor 2 (NRF2) activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7A11 levels.	sulforaphane	64-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-43
35256941-7	2022	Nuclear factor erythroid 2-related factor 2 (NRF2) activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7A11 levels.	sulforaphane	64-76	nuclear factor, erythroid derived 2, like 2	Mus musculus	45-49
35256941-7	2022	Nuclear factor erythroid 2-related factor 2 (NRF2) activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7A11 levels.	sulforaphane	64-76	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	189-196
35256941-9	2022	These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM; sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.	sulforaphane	92-104	nuclear factor, erythroid derived 2, like 2	Mus musculus	172-176
35126161-10	2022	Results: Sulforaphane ameliorated the skin lesions in IMQ-induced psoriasis-like mice and the renal damage in lupus-prone MRL/lpr mice.	sulforaphane	9-21	Fas (TNF receptor superfamily member 6)	Mus musculus	126-129
34559743-0	2022	Sulforaphane-Dependent Up-Regulation of NRF2 Activity Alleviates Both Systemic Inflammatory Response and Lung Injury After Hemorrhagic Shock/Resuscitation In Mice.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
34559743-2	2022	As an effective activator of the nuclear factor-erythroid factor 2 related factor 2 (Nrf2) pathway, sulforaphane (SFN) exerts antioxidant and anti-inflammatory effects.	sulforaphane	100-112	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
34559743-2	2022	As an effective activator of the nuclear factor-erythroid factor 2 related factor 2 (Nrf2) pathway, sulforaphane (SFN) exerts antioxidant and anti-inflammatory effects.	sulforaphane	114-117	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
34559743-12	2022	Sulforaphane enhanced pulmonary Nrf2 activity and the Nrf2-activation of AM, while it decreased lung damage.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	32-36
34559743-12	2022	Sulforaphane enhanced pulmonary Nrf2 activity and the Nrf2-activation of AM, while it decreased lung damage.	sulforaphane	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
35126161-11	2022	In IMQ-induced psoriasis-like mice, sulforaphane reduced the proportions of Th1 and Th17 cells and increased the expression of antioxidant gene Prdx1.	sulforaphane	36-48	peroxiredoxin 1	Mus musculus	144-149
35126161-12	2022	In lupus-prone MRL/lpr mice, sulforaphane increased the lifespan and the expression of Prdx1, and decreased the proportions of plasma cells, Tfh cells, neutrophils, and dendritic cells in the dLNs and spleens and the concentration of MDA.	sulforaphane	29-41	Fas (TNF receptor superfamily member 6)	Mus musculus	19-22
35126161-12	2022	In lupus-prone MRL/lpr mice, sulforaphane increased the lifespan and the expression of Prdx1, and decreased the proportions of plasma cells, Tfh cells, neutrophils, and dendritic cells in the dLNs and spleens and the concentration of MDA.	sulforaphane	29-41	peroxiredoxin 1	Mus musculus	87-92
35126161-13	2022	Conclusion: Sulforaphane has significant therapeutic effects on IMQ-induced psoriasis-like mice and lupus-like MRL/Lpr mice by reducing inflammatory and autoimmune-related cells and oxidative stress.	sulforaphane	12-24	Fas (TNF receptor superfamily member 6)	Mus musculus	115-118
35096424-4	2022	We found that, at a concentration as low as one-tenth that of allyl isothiocyanate, sulforaphane reduced triacylglycerol levels, lipid-filled adipocyte quantity, and mRNA and protein levels of CCAAT-enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma).	sulforaphane	84-96	CCAAT enhancer binding protein alpha	Homo sapiens	193-229
35096424-4	2022	We found that, at a concentration as low as one-tenth that of allyl isothiocyanate, sulforaphane reduced triacylglycerol levels, lipid-filled adipocyte quantity, and mRNA and protein levels of CCAAT-enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma).	sulforaphane	84-96	CCAAT enhancer binding protein alpha	Homo sapiens	231-241
35096424-4	2022	We found that, at a concentration as low as one-tenth that of allyl isothiocyanate, sulforaphane reduced triacylglycerol levels, lipid-filled adipocyte quantity, and mRNA and protein levels of CCAAT-enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma).	sulforaphane	84-96	peroxisome proliferator activated receptor gamma	Homo sapiens	247-295
35096424-4	2022	We found that, at a concentration as low as one-tenth that of allyl isothiocyanate, sulforaphane reduced triacylglycerol levels, lipid-filled adipocyte quantity, and mRNA and protein levels of CCAAT-enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma).	sulforaphane	84-96	peroxisome proliferator activated receptor gamma	Homo sapiens	297-306
35052660-0	2022	Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2.	sulforaphane	72-84	renin binding protein	Rattus norvegicus	0-3
35052660-0	2022	Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2.	sulforaphane	72-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-128
35052660-4	2022	Herein, we investigated the role of sulforaphane, a well-known NRF2 activator, on age-related mitochondrial and kidney dysfunction.	sulforaphane	36-48	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
35052660-4	2022	Herein, we investigated the role of sulforaphane, a well-known NRF2 activator, on age-related mitochondrial and kidney dysfunction.	sulforaphane	36-48	renin binding protein	Rattus norvegicus	82-85
35052660-7	2022	Sulforaphane significantly improved mitochondrial function and ameliorated kidney injury by increasing cortical NRF2 expression and activity and decreasing protein expression of KEAP1, an NRF2 repressor.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	112-116
35052660-7	2022	Sulforaphane significantly improved mitochondrial function and ameliorated kidney injury by increasing cortical NRF2 expression and activity and decreasing protein expression of KEAP1, an NRF2 repressor.	sulforaphane	0-12	Kelch-like ECH-associated protein 1	Rattus norvegicus	178-183
35052660-7	2022	Sulforaphane significantly improved mitochondrial function and ameliorated kidney injury by increasing cortical NRF2 expression and activity and decreasing protein expression of KEAP1, an NRF2 repressor.	sulforaphane	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	188-192
35052660-9	2022	Taken together, our results provide novel insights into the protective role of the NRF2 pathway in kidneys during aging and highlight the therapeutic potential of sulforaphane in mitigating kidney dysfunction in elders.	sulforaphane	163-175	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
35181615-8	2022	CONCLUSION: By targeting the Sirt1, EZH2 and CXCR4 pathways using relatively non-toxic adjuvant therapeutic agents such as metformin, melatonin, curcumin, sulforaphane, vitamin D3 and plerixafor, we should be able to target the biology of DLBCL.	sulforaphane	155-167	sirtuin 1	Homo sapiens	29-34