PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28752270-0 2017 Combination treatment with dendrosomal nanocurcumin and doxorubicin improves anticancer effects on breast cancer cells through modulating CXCR4/NF-kappaB/Smo regulatory network. nanocurcumin 39-51 C-X-C motif chemokine receptor 4 Homo sapiens 138-143 28752270-0 2017 Combination treatment with dendrosomal nanocurcumin and doxorubicin improves anticancer effects on breast cancer cells through modulating CXCR4/NF-kappaB/Smo regulatory network. nanocurcumin 39-51 nuclear factor kappa B subunit 1 Homo sapiens 144-153 28752270-0 2017 Combination treatment with dendrosomal nanocurcumin and doxorubicin improves anticancer effects on breast cancer cells through modulating CXCR4/NF-kappaB/Smo regulatory network. nanocurcumin 39-51 smoothened, frizzled class receptor Homo sapiens 154-157 27165229-10 2016 The aim of the current study was to investigate the effect of dendrosomal nanocurcumin (DNC) on expression of mir-34 family members in two HCC cell lines, HepG2 and Huh7. nanocurcumin 74-86 microRNA 34a Homo sapiens 110-116 28698350-0 2017 Efficacy of nanocurcumin supplementation on insulin resistance, lipids, inflammatory factors and nesfatin among obese patients with non-alcoholic fatty liver disease (NAFLD): a trial protocol. nanocurcumin 12-24 insulin Homo sapiens 44-51 27137748-0 2017 Enhanced nanocurcumin toxicity against (PC3) tumor and microbial by using magnetic field in vitro. nanocurcumin 9-21 chromobox 8 Homo sapiens 40-43 27137748-2 2017 In this study, nanocurcumin combined with 8 mT AC static magnetic field was used to enhance cellular uptake, bioavailability, and ultimate efficiency of curcumin against prostate cancer cell line (PC3), four bacteria strains (two Gram positive: Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 29213 and two Gram negative: Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), mammalian cell line (HEK) and human erythrocytes (RBC). nanocurcumin 15-27 chromobox 8 Homo sapiens 197-200 27137748-3 2017 The efficiency (E%) between IC50 of nanocurcumin combined with magnetic field (NANOCUR-MF) and control against PC3 was 35.93%, which is three times higher compared to curcumin combined with magnetic field (CUR-MF); i.e., 10.77%. nanocurcumin 36-48 chromobox 8 Homo sapiens 111-114 27626325-12 2016 Nanocurcumin supplementation decreased HH-induced RVH and apoptosis while modulating cardiac cGMP/cGK-1 signaling, and maintaining CaMkinase II, intracellular calcium levels and redox status better than curcumin. nanocurcumin 0-12 protein kinase cGMP-dependent 1 Rattus norvegicus 98-103 27534650-6 2016 The protective efficacy of nanocurcumin was analysed by examination of Akt/Erk signalling cascade by western blot. nanocurcumin 27-39 AKT serine/threonine kinase 1 Rattus norvegicus 71-74 27534650-6 2016 The protective efficacy of nanocurcumin was analysed by examination of Akt/Erk signalling cascade by western blot. nanocurcumin 27-39 Eph receptor B1 Rattus norvegicus 75-78 27534650-9 2016 Nanocurcumin treatment prevented lung edema formation and restored expression levels of ET-1/2/3 and its receptors while restoring the blood analytes, circulatory cytokines and pulmonary redox status better than curcumin. nanocurcumin 0-12 endothelin 1 Rattus norvegicus 88-96 27534650-10 2016 Modulation in Akt/Erk signalling pathway in rat lungs under HH confirmed the protective efficacy of nanocurcumin. nanocurcumin 100-112 AKT serine/threonine kinase 1 Rattus norvegicus 14-17 27534650-10 2016 Modulation in Akt/Erk signalling pathway in rat lungs under HH confirmed the protective efficacy of nanocurcumin. nanocurcumin 100-112 Eph receptor B1 Rattus norvegicus 18-21 27106025-6 2016 Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. nanocurcumin 13-25 mitogen-activated protein kinase 8 Homo sapiens 53-76 27106025-6 2016 Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. nanocurcumin 13-25 mitogen-activated protein kinase 8 Homo sapiens 78-81 27106025-6 2016 Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. nanocurcumin 13-25 caspase 3 Homo sapiens 114-123 27106025-6 2016 Photoexcited nanocurcumin induced phosphorylation of c-Jun N-terminal kinase (JNK), mitochondrial depolarization, caspase-3 activation, and cleavage of poly (ADP-ribose) polymerase, indicating apoptotic cell death. nanocurcumin 13-25 poly(ADP-ribose) polymerase 1 Homo sapiens 152-180 27106025-7 2016 Accordingly, pharmacologial inhibition of JNK and caspase activity rescued cancer cells from photoexcited nanocurcumin. nanocurcumin 106-118 mitogen-activated protein kinase 8 Homo sapiens 42-45 27106025-9 2016 By demonstrating the ability of photoexcited nanocurcumin to induce oxidative-stress independent, JNK- and caspase-dependent apoptosis, our results support its further investigation in cancer therapy. nanocurcumin 45-57 mitogen-activated protein kinase 8 Homo sapiens 98-114 27165229-10 2016 The aim of the current study was to investigate the effect of dendrosomal nanocurcumin (DNC) on expression of mir-34 family members in two HCC cell lines, HepG2 and Huh7. nanocurcumin 74-86 MIR7-3 host gene Homo sapiens 165-169 26406246-6 2015 Nanocurcumin prevented translocation of p53 to mitochondria by stabilizing mitochondrial membrane potential and de-stressed hypertrophied HVCM cells by significant restoration in lactate, acetyl-coenzyme A, pyruvate and glucose content along with lactate dehydrogenase (LDH) and 5" adenosine monophosphate-activated protein kinase (AMPKalpha) activity. nanocurcumin 0-12 tumor protein p53 Homo sapiens 40-43 26406246-7 2015 Significant restoration in glucose and modulation of GLUT-1 and GLUT-4 levels confirmed that nanocurcumin mediated prevention of substrate switching. nanocurcumin 93-105 solute carrier family 2 member 1 Homo sapiens 53-59 26406246-7 2015 Significant restoration in glucose and modulation of GLUT-1 and GLUT-4 levels confirmed that nanocurcumin mediated prevention of substrate switching. nanocurcumin 93-105 solute carrier family 2 member 4 Homo sapiens 64-70 26406246-8 2015 Nanocurcumin prevented of mitochondrial stress as confirmed by c-fos/c-jun/p53 signalling. nanocurcumin 0-12 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 63-68 26406246-8 2015 Nanocurcumin prevented of mitochondrial stress as confirmed by c-fos/c-jun/p53 signalling. nanocurcumin 0-12 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 69-74 26406246-8 2015 Nanocurcumin prevented of mitochondrial stress as confirmed by c-fos/c-jun/p53 signalling. nanocurcumin 0-12 tumor protein p53 Homo sapiens 75-78 26406246-9 2015 The data indicates decrease in p-300 histone acetyl transferase (HAT) mediated histone acetylation and GATA-4 activation as pharmacological targets of nanocurcumin in preventing hypoxia induced hypertrophy. nanocurcumin 151-163 GATA binding protein 4 Homo sapiens 103-109 25846484-5 2015 The molecular mechanism underlying the protective efficacy of nanocurcumin was evaluated in regulating Raf-1/Erk-1/2 apoptosis by caspase-3/-7 pathway and oxidative stress. nanocurcumin 62-74 Raf-1 proto-oncogene, serine/threonine kinase Rattus norvegicus 103-108 25846484-5 2015 The molecular mechanism underlying the protective efficacy of nanocurcumin was evaluated in regulating Raf-1/Erk-1/2 apoptosis by caspase-3/-7 pathway and oxidative stress. nanocurcumin 62-74 mitogen activated protein kinase 3 Rattus norvegicus 109-116 25846484-5 2015 The molecular mechanism underlying the protective efficacy of nanocurcumin was evaluated in regulating Raf-1/Erk-1/2 apoptosis by caspase-3/-7 pathway and oxidative stress. nanocurcumin 62-74 caspase 3 Rattus norvegicus 130-139 25846484-6 2015 Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p <= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin. nanocurcumin 0-12 natriuretic peptide A Rattus norvegicus 129-154 25846484-6 2015 Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p <= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin. nanocurcumin 0-12 caspase 3 Rattus norvegicus 167-176 25846484-6 2015 Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p <= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin. nanocurcumin 0-12 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 225-256 25846484-6 2015 Nanocurcumin ameliorated hypoxia-induced hypertrophy and apoptosis in H9c2 cells significantly (p <= 0.01), by downregulating atrial natriuretic factor expression, caspase-3/-7 activation, oxidative stress and stabilizing hypoxia-inducible factor-1alpha (HIF-1alpha) better than curcumin. nanocurcumin 0-12 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 258-268 25747863-11 2015 The cleaved caspase-3 and -9a was significantly reduced in 300mug/kg nanocurcumin treatment groups (P<0.05). nanocurcumin 69-81 caspase 3 Rattus norvegicus 12-29 25747863-12 2015 CONCLUSION: Treatment with nanocurcumin exerts its neuroprotective effect through the upward regulation of NF-kappaB (p65) and also reduced mitochondrion related caspase-9a expression. nanocurcumin 27-39 synaptotagmin 1 Rattus norvegicus 118-121 25747863-12 2015 CONCLUSION: Treatment with nanocurcumin exerts its neuroprotective effect through the upward regulation of NF-kappaB (p65) and also reduced mitochondrion related caspase-9a expression. nanocurcumin 27-39 caspase 9 Rattus norvegicus 162-171 25747863-13 2015 Besides, nanocurcumin decreased CSF levels of TNF-alpha and IL-1beta, which may contribute to the extrinsic antiapoptotic effect. nanocurcumin 9-21 colony stimulating factor 2 Rattus norvegicus 32-35 25747863-13 2015 Besides, nanocurcumin decreased CSF levels of TNF-alpha and IL-1beta, which may contribute to the extrinsic antiapoptotic effect. nanocurcumin 9-21 tumor necrosis factor Rattus norvegicus 46-55 25747863-13 2015 Besides, nanocurcumin decreased CSF levels of TNF-alpha and IL-1beta, which may contribute to the extrinsic antiapoptotic effect. nanocurcumin 9-21 interleukin 1 beta Rattus norvegicus 60-68 23292317-9 2013 Coadministration of nanocurcumin with lead restored the altered delta-aminolevulinic acid dehydratase activity, glutathione (reduced and oxidized) levels, and also decreased reactive oxygen species, and thiobarbituric acid reactive substances levels. nanocurcumin 20-32 aminolevulinate, delta-, dehydratase Mus musculus 64-101 25747863-7 2015 RESULTS: Nanocurcumin significantly reduced the bio-expression of NF-kappaB (p65), when compared with the SAH groups. nanocurcumin 9-21 synaptotagmin 1 Rattus norvegicus 77-80 25747863-8 2015 The levels of IL-1beta and IL-6 were increased in animals subjected to SAH, compared with the healthy controls, but absent in the high dose nanocurcumin+SAH group. nanocurcumin 140-152 interleukin 1 beta Rattus norvegicus 14-22 25747863-8 2015 The levels of IL-1beta and IL-6 were increased in animals subjected to SAH, compared with the healthy controls, but absent in the high dose nanocurcumin+SAH group. nanocurcumin 140-152 interleukin 6 Rattus norvegicus 27-31 24330336-9 2013 RESULTS: Results of the manual patch clamp assay of HEK 293 cells clearly illustrated that our hybrid nanocurcumin formulation prevented the curcumin induced inhibition of hERG K+ channel at concentrations higher than the therapeutic concentrations of curcumin. nanocurcumin 102-114 ETS transcription factor ERG Homo sapiens 172-176 33789145-5 2021 In both mild and severe COVID-19 patients, Nanocurcumin could considerably upregulate the frequency of Treg cells, the expression levels of FoxP3, IL-10, IL-35, and TGF-beta, as well as the serum secretion levels of cytokines in the Nanocurcumin-treated group compared to the placebo group. nanocurcumin 43-55 forkhead box P3 Homo sapiens 140-145 34482462-0 2022 Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-kappaB and HMGB1 signaling pathways in rats. nanocurcumin 0-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 34482462-0 2022 Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-kappaB and HMGB1 signaling pathways in rats. nanocurcumin 0-12 toll-like receptor 4 Rattus norvegicus 121-125 34482462-0 2022 Nanocurcumin alleviates inflammation and oxidative stress in LPS-induced mastitis via activation of Nrf2 and suppressing TLR4-mediated NF-kappaB and HMGB1 signaling pathways in rats. nanocurcumin 0-12 high mobility group box 1 Rattus norvegicus 149-154 34482462-6 2022 The results showed that nanocurcumin significantly attenuated the lipid peroxidation (MDA), oxidized glutathione, the release of pro-inflammatory cytokines (TNF-alpha and IL-1beta), and the gene expression of TLR4, NF-kappaB p65, and HMGB1. nanocurcumin 24-36 tumor necrosis factor Rattus norvegicus 157-166 34482462-6 2022 The results showed that nanocurcumin significantly attenuated the lipid peroxidation (MDA), oxidized glutathione, the release of pro-inflammatory cytokines (TNF-alpha and IL-1beta), and the gene expression of TLR4, NF-kappaB p65, and HMGB1. nanocurcumin 24-36 interleukin 1 alpha Rattus norvegicus 171-179 34482462-6 2022 The results showed that nanocurcumin significantly attenuated the lipid peroxidation (MDA), oxidized glutathione, the release of pro-inflammatory cytokines (TNF-alpha and IL-1beta), and the gene expression of TLR4, NF-kappaB p65, and HMGB1. nanocurcumin 24-36 toll-like receptor 4 Rattus norvegicus 209-213 34482462-6 2022 The results showed that nanocurcumin significantly attenuated the lipid peroxidation (MDA), oxidized glutathione, the release of pro-inflammatory cytokines (TNF-alpha and IL-1beta), and the gene expression of TLR4, NF-kappaB p65, and HMGB1. nanocurcumin 24-36 high mobility group box 1 Rattus norvegicus 234-239 35384739-0 2022 A Nanocurcumin and Pyrroloquinoline Quinone Formulation Prevents Hypobaric Hypoxia-Induced Skeletal Muscle Atrophy by Modulating NF-kappaB Signaling Pathway. nanocurcumin 2-14 nuclear factor kappa B subunit 1 Homo sapiens 129-138 35384739-2 2022 A nanocurcumin and pyrroloquinoline quinone formulation prevents hypobaric hypoxia-induced skeletal muscle atrophy by modulating NF-kappaB signaling pathway. nanocurcumin 2-14 nuclear factor kappa B subunit 1 Homo sapiens 129-138 34614532-0 2022 Evaluation of Protective Effects of Curcumin and Nanocurcumin on Aluminium Phosphide-Induced Subacute Lung Injury in Rats: Modulation of Oxidative Stress through SIRT1/FOXO3 Signalling Pathway. nanocurcumin 49-61 sirtuin 1 Rattus norvegicus 162-167 34614532-0 2022 Evaluation of Protective Effects of Curcumin and Nanocurcumin on Aluminium Phosphide-Induced Subacute Lung Injury in Rats: Modulation of Oxidative Stress through SIRT1/FOXO3 Signalling Pathway. nanocurcumin 49-61 forkhead box O3 Rattus norvegicus 168-173 34614532-9 2022 RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue. nanocurcumin 22-34 catalase Rattus norvegicus 192-195 34614532-9 2022 RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue. nanocurcumin 22-34 sirtuin 1 Rattus norvegicus 285-290 34614532-9 2022 RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue. nanocurcumin 22-34 forkhead box O3 Rattus norvegicus 292-297 34614532-9 2022 RESULTS: Curcumin and nanocurcumin produced a remarkable improvement in AlP-induced lung damage through reduction of MDA, induction of antioxidant capacity (TAC, TTG) and antioxidant enzymes (CAT, GPx), modulation of histopathological changes, and up-regulation of genes expression of SIRT1, FOXO3, FOXO1 in lung tissue. nanocurcumin 22-34 forkhead box O1 Rattus norvegicus 299-304 34653732-7 2021 Significant increases in serum TGF-beta and IL-10 were seen in nanocurcumin group compared with baseline (P < 0.001) and placebo group (P = 0.001 and P < 0.001, respectively). nanocurcumin 63-75 transforming growth factor alpha Homo sapiens 31-39 34653732-7 2021 Significant increases in serum TGF-beta and IL-10 were seen in nanocurcumin group compared with baseline (P < 0.001) and placebo group (P = 0.001 and P < 0.001, respectively). nanocurcumin 63-75 interleukin 10 Homo sapiens 44-49 35112841-0 2022 Nanocurcumin Potently Inhibits SARS-CoV-2 Spike Protein-Induced Cytokine Storm by Deactivation of MAPK/NF-kappaB Signaling in Epithelial Cells. nanocurcumin 0-12 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 42-47 35112841-0 2022 Nanocurcumin Potently Inhibits SARS-CoV-2 Spike Protein-Induced Cytokine Storm by Deactivation of MAPK/NF-kappaB Signaling in Epithelial Cells. nanocurcumin 0-12 nuclear factor kappa B subunit 1 Homo sapiens 103-112 33789145-5 2021 In both mild and severe COVID-19 patients, Nanocurcumin could considerably upregulate the frequency of Treg cells, the expression levels of FoxP3, IL-10, IL-35, and TGF-beta, as well as the serum secretion levels of cytokines in the Nanocurcumin-treated group compared to the placebo group. nanocurcumin 43-55 interleukin 10 Homo sapiens 147-152 33789145-5 2021 In both mild and severe COVID-19 patients, Nanocurcumin could considerably upregulate the frequency of Treg cells, the expression levels of FoxP3, IL-10, IL-35, and TGF-beta, as well as the serum secretion levels of cytokines in the Nanocurcumin-treated group compared to the placebo group. nanocurcumin 43-55 transforming growth factor alpha Homo sapiens 165-173 33404738-0 2021 Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1beta and TNFalpha in the chronic constriction injury model of neuropathic pain. nanocurcumin 8-20 interleukin 1 alpha Rattus norvegicus 125-133 33544450-9 2021 Our findings showed that nanocurcumin had better hepatoprotective effect than curcumin in liver damage after PQ exposure most likely through modulation of oxidative stress and genes expression of Nrf2 pathway. nanocurcumin 25-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 196-200 33956815-0 2021 Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-beta, VEGF, TNF-alpha and IL-6 expressions involved in wound healing process. nanocurcumin 37-49 transforming growth factor alpha Mus musculus 156-164 33956815-0 2021 Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-beta, VEGF, TNF-alpha and IL-6 expressions involved in wound healing process. nanocurcumin 37-49 vascular endothelial growth factor A Mus musculus 166-170 33956815-0 2021 Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-beta, VEGF, TNF-alpha and IL-6 expressions involved in wound healing process. nanocurcumin 37-49 tumor necrosis factor Mus musculus 172-181 33956815-0 2021 Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-beta, VEGF, TNF-alpha and IL-6 expressions involved in wound healing process. nanocurcumin 37-49 interleukin 6 Mus musculus 186-190 33544450-0 2021 Evaluation of the hepatoprotective effects of curcumin and nanocurcumin against paraquat-induced liver injury in rats: Modulation of oxidative stress and Nrf2 pathway. nanocurcumin 59-71 NFE2 like bZIP transcription factor 2 Rattus norvegicus 154-158 33544450-3 2021 The aim of this study is to evaluate and compare the hepatoprotective effects of curcumin and nanocurcumin against liver damage caused by sub-acute exposure with PQ via modulation of oxidative stress and genes expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. nanocurcumin 94-106 NFE2 like bZIP transcription factor 2 Rattus norvegicus 224-267 33544450-3 2021 The aim of this study is to evaluate and compare the hepatoprotective effects of curcumin and nanocurcumin against liver damage caused by sub-acute exposure with PQ via modulation of oxidative stress and genes expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. nanocurcumin 94-106 NFE2 like bZIP transcription factor 2 Rattus norvegicus 269-273 33559343-6 2021 FINDINGS: Serum levels of IL-6 and TNF-alpha were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). nanocurcumin 136-148 interleukin 6 Homo sapiens 26-30 33559343-6 2021 FINDINGS: Serum levels of IL-6 and TNF-alpha were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). nanocurcumin 136-148 tumor necrosis factor Homo sapiens 35-44 33559343-6 2021 FINDINGS: Serum levels of IL-6 and TNF-alpha were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). nanocurcumin 136-148 interleukin 6 Homo sapiens 184-188 33559343-6 2021 FINDINGS: Serum levels of IL-6 and TNF-alpha were similar in the two groups at baseline but were lower after 12 weeks of treatment with nanocurcumin compared to placebo (P = 0.024 for IL-6 and 0.02 for TNF). nanocurcumin 136-148 tumor necrosis factor Homo sapiens 35-38 33404738-0 2021 Chronic nanocurcumin treatment ameliorates pain-related behavior, improves spatial memory, and reduces hippocampal levels of IL-1beta and TNFalpha in the chronic constriction injury model of neuropathic pain. nanocurcumin 8-20 tumor necrosis factor Rattus norvegicus 138-146 33404738-9 2021 Chronic treatment with nanocurcumin significantly increased pain threshold (P < 0.001; F = 27.63, F = 20.58), improved spatial memory (P < 0.01; F = 47.37), and decreased the hippocampal levels of IL-1beta (P < 0.001; F = 33.57) and TNF-alpha (P < 0.01; F = 7.25) in CCI rats. nanocurcumin 23-35 interleukin 1 alpha Rattus norvegicus 197-205 33404738-9 2021 Chronic treatment with nanocurcumin significantly increased pain threshold (P < 0.001; F = 27.63, F = 20.58), improved spatial memory (P < 0.01; F = 47.37), and decreased the hippocampal levels of IL-1beta (P < 0.001; F = 33.57) and TNF-alpha (P < 0.01; F = 7.25) in CCI rats. nanocurcumin 23-35 tumor necrosis factor Rattus norvegicus 233-242 33404738-10 2021 CONCLUSION: Chronic nanocurcumin can ameliorate pain-related behavior, improve spatial learning and memory deficits, and is associated with the reduction of IL-1beta and TNF-alpha levels in the hippocampus in CCI rats. nanocurcumin 20-32 interleukin 1 alpha Rattus norvegicus 157-165 33404738-10 2021 CONCLUSION: Chronic nanocurcumin can ameliorate pain-related behavior, improve spatial learning and memory deficits, and is associated with the reduction of IL-1beta and TNF-alpha levels in the hippocampus in CCI rats. nanocurcumin 20-32 tumor necrosis factor Rattus norvegicus 170-179 32676763-7 2020 The sensitivity of the described method in terms of detection limits was 0.3 and 0.1 mug mL-1 for curcumin and nanocurcumin, respectively. nanocurcumin 111-123 L1 cell adhesion molecule Mus musculus 89-93 32589998-0 2020 Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTOR and TNF-alpha modulations. nanocurcumin 0-12 AKT serine/threonine kinase 1 Rattus norvegicus 119-122 32589998-0 2020 Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTOR and TNF-alpha modulations. nanocurcumin 0-12 mechanistic target of rapamycin kinase Rattus norvegicus 123-127 32589998-0 2020 Nanocurcumin alleviates insulin resistance and pancreatic deficits in polycystic ovary syndrome rats: Insights on PI3K/AkT/mTOR and TNF-alpha modulations. nanocurcumin 0-12 tumor necrosis factor Rattus norvegicus 132-141 32589998-13 2020 Nanocurcumin significantly improved oxidative markers, glucose indices and TNF-alpha levels. nanocurcumin 0-12 tumor necrosis factor Rattus norvegicus 75-84 33536913-9 2020 Co-treatment of cisplatin and nanocurcumin also reduced JAK expression, STAT3 phosphorylation, and reduced IL-6 concentrations. nanocurcumin 30-42 signal transducer and activator of transcription 3 Rattus norvegicus 72-77 33536913-9 2020 Co-treatment of cisplatin and nanocurcumin also reduced JAK expression, STAT3 phosphorylation, and reduced IL-6 concentrations. nanocurcumin 30-42 interleukin 6 Rattus norvegicus 107-111 33536913-10 2020 Altogether, nanocurcumin, given as a co-treatment with cisplatin has therapeutic potential in ovarian cancer models by inhibiting proliferation through downregulation of PI3K/Akt and JAK/STAT3 signaling pathways. nanocurcumin 12-24 AKT serine/threonine kinase 1 Rattus norvegicus 175-178 33536913-10 2020 Altogether, nanocurcumin, given as a co-treatment with cisplatin has therapeutic potential in ovarian cancer models by inhibiting proliferation through downregulation of PI3K/Akt and JAK/STAT3 signaling pathways. nanocurcumin 12-24 signal transducer and activator of transcription 3 Rattus norvegicus 187-192 31074089-9 2020 The RT-PCR data indicated that the expression of miR-17 and miR-27 were significantly decreased following nanocurcumin treatment while miR-146a and FoxP3 were significantly increased. nanocurcumin 106-118 microRNA 17 Homo sapiens 49-55 32031071-0 2020 Nanocurcumin inhibits angiogenesis via down-regulating hif1a/vegfa signaling in Zebrafish. nanocurcumin 0-12 hypoxia inducible factor 1 subunit alpha a Danio rerio 55-60 32031071-0 2020 Nanocurcumin inhibits angiogenesis via down-regulating hif1a/vegfa signaling in Zebrafish. nanocurcumin 0-12 vascular endothelial growth factor Aa Danio rerio 61-66 31074089-9 2020 The RT-PCR data indicated that the expression of miR-17 and miR-27 were significantly decreased following nanocurcumin treatment while miR-146a and FoxP3 were significantly increased. nanocurcumin 106-118 microRNA 27a Homo sapiens 60-66 31074089-9 2020 The RT-PCR data indicated that the expression of miR-17 and miR-27 were significantly decreased following nanocurcumin treatment while miR-146a and FoxP3 were significantly increased. nanocurcumin 106-118 microRNA 146a Homo sapiens 135-143 31074089-9 2020 The RT-PCR data indicated that the expression of miR-17 and miR-27 were significantly decreased following nanocurcumin treatment while miR-146a and FoxP3 were significantly increased. nanocurcumin 106-118 forkhead box P3 Homo sapiens 148-153 31074089-10 2020 Moreover, nanocurcumin-treated group had high levels of IL-10 and TGF-beta and low levels of IL-6 production than control group. nanocurcumin 10-22 interleukin 10 Homo sapiens 56-61 31074089-10 2020 Moreover, nanocurcumin-treated group had high levels of IL-10 and TGF-beta and low levels of IL-6 production than control group. nanocurcumin 10-22 transforming growth factor beta 1 Homo sapiens 66-74 31074089-10 2020 Moreover, nanocurcumin-treated group had high levels of IL-10 and TGF-beta and low levels of IL-6 production than control group. nanocurcumin 10-22 interleukin 6 Homo sapiens 93-97 30622449-0 2018 Prophylactic Administration of Nanocurcumin Abates the Incidence of Liver Toxicity Induced by an Overdose of Copper Sulfate: Role of CYP4502E1, NF-kappaB and Bax Expressions. nanocurcumin 31-43 BCL2 associated X, apoptosis regulator Homo sapiens 158-161 31610197-8 2019 KEY FINDINGS: Our data indicates that nanocurcumin -in a specific dose-reduces the expression of Nestin with no significant effect on insulin expression in mRNA and protein level. nanocurcumin 38-50 nestin Rattus norvegicus 97-103 30805973-9 2019 Posttreatment data of miR-155 and miR-200 in the nanocurcumin and placebo groups also showed a higher expression level in the placebo group compared with nanocurcumin-treated patients. nanocurcumin 49-61 microRNA 155 Homo sapiens 22-29 30805973-9 2019 Posttreatment data of miR-155 and miR-200 in the nanocurcumin and placebo groups also showed a higher expression level in the placebo group compared with nanocurcumin-treated patients. nanocurcumin 154-166 microRNA 155 Homo sapiens 22-29 30984574-6 2019 In this study, we aimed to produce a BSA-based nanocurcumin to assess its effect on 6-hydroxydopamine (6-OHDA)-induced death and Akt signaling disruption in SH-SY5Y cells. nanocurcumin 47-59 AKT serine/threonine kinase 1 Homo sapiens 129-132 30380516-0 2018 Nanocurcumin ameliorates Staphylococcus aureus-induced mastitis in mouse by suppressing NF-kappaB signaling and inflammation. nanocurcumin 0-12 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 88-97 30343126-0 2018 Chitosan encapsulated nanocurcumin induces GLUT-4 translocation and exhibits enhanced anti-hyperglycemic function. nanocurcumin 22-34 solute carrier family 2 member 4 Homo sapiens 43-49 29852475-5 2018 Post-treatment evaluation of the nanocurcumin group revealed a significant decrease in Th17 associated parameters such as Th17 frequency (p = 0.029), expression levels of RORgammat (p < 0.0001) and IL-17 (p = 0.0044) and also secretion level of IL-17 (p = 0.0011), but IL-23 mRNA expression levels and IL-23 concentration were not influenced by nanocurcumin. nanocurcumin 33-45 interleukin 17A Homo sapiens 201-206 29852475-5 2018 Post-treatment evaluation of the nanocurcumin group revealed a significant decrease in Th17 associated parameters such as Th17 frequency (p = 0.029), expression levels of RORgammat (p < 0.0001) and IL-17 (p = 0.0044) and also secretion level of IL-17 (p = 0.0011), but IL-23 mRNA expression levels and IL-23 concentration were not influenced by nanocurcumin. nanocurcumin 33-45 interleukin 17A Homo sapiens 248-253 29852475-5 2018 Post-treatment evaluation of the nanocurcumin group revealed a significant decrease in Th17 associated parameters such as Th17 frequency (p = 0.029), expression levels of RORgammat (p < 0.0001) and IL-17 (p = 0.0044) and also secretion level of IL-17 (p = 0.0011), but IL-23 mRNA expression levels and IL-23 concentration were not influenced by nanocurcumin. nanocurcumin 33-45 interleukin 23 subunit alpha Homo sapiens 272-277 29852475-5 2018 Post-treatment evaluation of the nanocurcumin group revealed a significant decrease in Th17 associated parameters such as Th17 frequency (p = 0.029), expression levels of RORgammat (p < 0.0001) and IL-17 (p = 0.0044) and also secretion level of IL-17 (p = 0.0011), but IL-23 mRNA expression levels and IL-23 concentration were not influenced by nanocurcumin. nanocurcumin 33-45 interleukin 23 subunit alpha Homo sapiens 305-310 28992682-0 2018 Nanocurcumin-Mediated Down-Regulation of Telomerase Via Stimulating TGFbeta1 Signaling Pathway in Hepatocellular Carcinoma Cells Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. nanocurcumin 0-12 transforming growth factor beta 1 Homo sapiens 68-76 28992682-2 2018 In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGFbeta1 pathway in a hepatocellular carcinoma cell line (Huh7). nanocurcumin 65-77 transforming growth factor beta 1 Homo sapiens 111-119 28992682-6 2018 RT-PCR analysis indicated that nanocurcumin results in augmentation of TGFbeta1 72 hours post treatment and leads to the reduction of telomerase expression 48 and 72 hours post exposure. nanocurcumin 31-43 transforming growth factor beta 1 Homo sapiens 71-79 28992682-7 2018 Also, up-regulation of Smad3 and E2F1 and down-regulation of Smad7 confirmed the effect of nanocurcumin on intermediate components of TGFbeta1 pathway. nanocurcumin 91-103 transforming growth factor beta 1 Homo sapiens 134-142