PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33953744-0 2021 miR-139-5p Regulates the Proliferation of Acute Promyelocytic Leukemia Cells by Targeting MNT. mir-139-5p 0-10 MAX network transcriptional repressor Homo sapiens 90-93 33675896-8 2021 In contrast to PMP22 silencing, miR-139-5p inhibition enhanced TGF-beta-induced hHSC activation; the effects of miR-139-5p inhibition on TGF-beta-induced hHSC activation were partially reversed by PMP22 silencing. mir-139-5p 32-42 transforming growth factor alpha Mus musculus 63-71 33675896-8 2021 In contrast to PMP22 silencing, miR-139-5p inhibition enhanced TGF-beta-induced hHSC activation; the effects of miR-139-5p inhibition on TGF-beta-induced hHSC activation were partially reversed by PMP22 silencing. mir-139-5p 112-122 transforming growth factor alpha Mus musculus 137-145 33675896-8 2021 In contrast to PMP22 silencing, miR-139-5p inhibition enhanced TGF-beta-induced hHSC activation; the effects of miR-139-5p inhibition on TGF-beta-induced hHSC activation were partially reversed by PMP22 silencing. mir-139-5p 112-122 peripheral myelin protein 22 Mus musculus 197-202 34051810-17 2021 MiR-139-5p inhibitor or SDC4 overexpression could restore the suppressive influence of silenced WDFY3-AS2 on tumor growth. mir-139-5p 0-10 WD repeat and FYVE domain containing 3 Mus musculus 96-101 34051810-17 2021 MiR-139-5p inhibitor or SDC4 overexpression could restore the suppressive influence of silenced WDFY3-AS2 on tumor growth. mir-139-5p 0-10 arylsulfatase A Mus musculus 102-105 34001135-0 2021 Mir-139-5p inhibits glioma cell proliferation and progression by targeting GABRA1. mir-139-5p 0-10 gamma-aminobutyric acid type A receptor subunit alpha1 Homo sapiens 75-81 34001135-11 2021 Finally, we validated that miR-139-5p affected glioma malignant biological behavior via targeting gamma-aminobutyric acid A receptor alpha 1(GABRA1) through rescue experiments. mir-139-5p 27-37 gamma-aminobutyric acid type A receptor subunit alpha1 Homo sapiens 141-147 33981163-0 2021 MiR-139-5p Targetedly Regulates YAF2 and Mediates the AKT/P38 MAPK Signaling Pathway to Alleviate the Metastasis of Non-Small Cell Lung Cancer Cells and Their Resistance Against Cisplatin. mir-139-5p 0-10 YY1 associated factor 2 Homo sapiens 32-36 33981163-0 2021 MiR-139-5p Targetedly Regulates YAF2 and Mediates the AKT/P38 MAPK Signaling Pathway to Alleviate the Metastasis of Non-Small Cell Lung Cancer Cells and Their Resistance Against Cisplatin. mir-139-5p 0-10 AKT serine/threonine kinase 1 Homo sapiens 54-57 33981163-8 2021 Overexpression of miR-139-5p and knockdown of YAF2 reversed the resistance of A549/DDP cells against DDP, inactivated p38 and Akt proteins, and inhibited the AKT/p38 MAPK signaling pathway. mir-139-5p 18-28 translocase of inner mitochondrial membrane 8A Homo sapiens 83-86 33981163-8 2021 Overexpression of miR-139-5p and knockdown of YAF2 reversed the resistance of A549/DDP cells against DDP, inactivated p38 and Akt proteins, and inhibited the AKT/p38 MAPK signaling pathway. mir-139-5p 18-28 translocase of inner mitochondrial membrane 8A Homo sapiens 101-104 33981163-8 2021 Overexpression of miR-139-5p and knockdown of YAF2 reversed the resistance of A549/DDP cells against DDP, inactivated p38 and Akt proteins, and inhibited the AKT/p38 MAPK signaling pathway. mir-139-5p 18-28 mitogen-activated protein kinase 14 Homo sapiens 118-121 33981163-8 2021 Overexpression of miR-139-5p and knockdown of YAF2 reversed the resistance of A549/DDP cells against DDP, inactivated p38 and Akt proteins, and inhibited the AKT/p38 MAPK signaling pathway. mir-139-5p 18-28 AKT serine/threonine kinase 1 Homo sapiens 126-129 33981163-8 2021 Overexpression of miR-139-5p and knockdown of YAF2 reversed the resistance of A549/DDP cells against DDP, inactivated p38 and Akt proteins, and inhibited the AKT/p38 MAPK signaling pathway. mir-139-5p 18-28 AKT serine/threonine kinase 1 Homo sapiens 158-161 33981163-9 2021 Furthermore, inhibiting the AKT/p38 MAPK signaling pathway with MK2206 resisted the effects of knock-down of miR-139-5p on DDP resistance in NSCLC cells. mir-139-5p 109-119 AKT serine/threonine kinase 1 Homo sapiens 28-31 33981163-9 2021 Furthermore, inhibiting the AKT/p38 MAPK signaling pathway with MK2206 resisted the effects of knock-down of miR-139-5p on DDP resistance in NSCLC cells. mir-139-5p 109-119 translocase of inner mitochondrial membrane 8A Homo sapiens 123-126 33981163-10 2021 Conclusion: MiR-139-5p targetedly regulates YAF2 and mediates the AKT/p38 MAPK signaling pathway to alleviate the metastasis of NSCLC cells and their resistance against cisplatin, which may be a novel target for improving the therapeutic effect on NSCLC. mir-139-5p 12-22 YY1 associated factor 2 Homo sapiens 44-48 33981163-10 2021 Conclusion: MiR-139-5p targetedly regulates YAF2 and mediates the AKT/p38 MAPK signaling pathway to alleviate the metastasis of NSCLC cells and their resistance against cisplatin, which may be a novel target for improving the therapeutic effect on NSCLC. mir-139-5p 12-22 AKT serine/threonine kinase 1 Homo sapiens 66-69 33953744-8 2021 miR-139-5p significantly inhibited the proliferation, invasion, and migration function of NB4 cells through targeting MNT. mir-139-5p 0-10 MAX network transcriptional repressor Homo sapiens 118-121 33937023-0 2021 miR-139-5p Loss-Mediated WTAP Activation Contributes to Hepatocellular Carcinoma Progression by Promoting the Epithelial to Mesenchymal Transition. mir-139-5p 0-10 WT1 associated protein Homo sapiens 25-29 33937023-11 2021 Moreover, the overexpression of WTAP could partly abolish the inhibitory effects of miR-139-5p on the HCC cell growth and invasion. mir-139-5p 84-94 WT1 associated protein Homo sapiens 32-36 33937023-13 2021 Conclusions: In summary, the results indicate that WTAP is a potential oncogene in HCC and miR-139-5p negatively regulates the WTAP expression. mir-139-5p 91-101 WT1 associated protein Homo sapiens 127-131 33937023-14 2021 MiR-139-5p/WTAP can be utilized as a potential therapeutic target for HCC. mir-139-5p 0-10 WT1 associated protein Homo sapiens 11-15 33789378-7 2021 Dual-Luciferase Reporter assay was used to analyze the interaction between miR-139-5p with TBX1. mir-139-5p 75-85 T-box transcription factor 1 Homo sapiens 91-95 33789378-15 2021 miR-139-5p mimic or inhibitor suppressed or promoted the expression of TBX1 protein in Eca109 and TE1 cells, respectively (all P<0.05). mir-139-5p 0-10 T-box transcription factor 1 Homo sapiens 71-75 33789378-17 2021 In addition, pcDNA3.1-TBX1 partially reversed the inhibition of miR-139-5p-mediated invasion ability (all P<0.05), while TBX1 siRNA partially reversed the enhancement of miR-139-5p inhibitor-mediated invasion ability (all P<0.05). mir-139-5p 64-74 T-box transcription factor 1 Homo sapiens 22-26 33789378-17 2021 In addition, pcDNA3.1-TBX1 partially reversed the inhibition of miR-139-5p-mediated invasion ability (all P<0.05), while TBX1 siRNA partially reversed the enhancement of miR-139-5p inhibitor-mediated invasion ability (all P<0.05). mir-139-5p 170-180 T-box transcription factor 1 Homo sapiens 121-125 33789378-18 2021 Conclusion: miR-139-5p suppressed ESCC cell proliferation and invasion by targeting TBX1. mir-139-5p 12-22 T-box transcription factor 1 Homo sapiens 84-88 33400954-9 2021 MiR-139-5p up-regulation or HDAC4 down-regulation alleviated pathological status, impaired oxidative stress, increased NGF and BDNF expression and inhibited neurons apoptosis of brain tissues in rats with HIBD. mir-139-5p 0-10 brain-derived neurotrophic factor Rattus norvegicus 127-131 33400954-11 2021 CONCLUSION: Our study highlights that miR-139-5p elevation or HDAC4 knockdown alleviated neurological deficit and induced neurons growth via Bcl-2 elevation. mir-139-5p 38-48 BCL2, apoptosis regulator Rattus norvegicus 141-146 33994349-8 2021 Eif4g2, a protein that supports neutrophil proliferation and differentiation, was identified as a key downstream mediator of miR-139-5p. mir-139-5p 125-135 eukaryotic translation initiation factor 4, gamma 2 Mus musculus 0-6 33609236-0 2021 miR-139-5p promotes neovascularization in diabetic retinopathy by regulating the phosphatase and tensin homolog. mir-139-5p 0-10 phosphatase and tensin homolog Mus musculus 81-111 33609236-5 2021 The miR-139-5p overexpression elevated cell migration, facilitated tube formation, and increased vascular endothelial growth factor (VEGF) protein level in the hRMECs. mir-139-5p 4-14 vascular endothelial growth factor A Mus musculus 97-131 33609236-5 2021 The miR-139-5p overexpression elevated cell migration, facilitated tube formation, and increased vascular endothelial growth factor (VEGF) protein level in the hRMECs. mir-139-5p 4-14 vascular endothelial growth factor A Mus musculus 133-137 33609236-6 2021 While the angiogenic effect of miR-139-5p overexpression was halted by an anti-VEGF antibody. mir-139-5p 31-41 vascular endothelial growth factor A Mus musculus 79-83 33609236-7 2021 Meanwhile, the miR-139-5p knockdown eliminated the VEGF-induced cell migration and tube formation in the hRMECs. mir-139-5p 15-25 vascular endothelial growth factor A Mus musculus 51-55 33609236-9 2021 PTEN overexpression removed the angiogenic effect of miR-139-5p overexpression, which led to reduced cell migration and tube formation. mir-139-5p 53-63 phosphatase and tensin homolog Mus musculus 0-4 33317757-8 2021 The target of miR-139-5p was predicted by starBase software, and the target relationship between miR-139-5p and ARF6 in BC cells was confirmed by dual-luciferase reporter assay. mir-139-5p 97-107 ADP ribosylation factor 6 Homo sapiens 112-116 33681946-5 2021 RESULTS: A web-based bioinformatic tool predicted that MyD88 was a target of miR-139-5p, which was verified by a dual luciferase reporter assay. mir-139-5p 77-87 myeloid differentiation primary response gene 88 Mus musculus 55-60 33681946-9 2021 CONCLUSION: miR-139-5p inhibits the TLR4/MyD88/NF-kappaB signaling pathway to alleviate acute lung injury in septic mice. mir-139-5p 12-22 toll-like receptor 4 Mus musculus 36-40 33681946-9 2021 CONCLUSION: miR-139-5p inhibits the TLR4/MyD88/NF-kappaB signaling pathway to alleviate acute lung injury in septic mice. mir-139-5p 12-22 myeloid differentiation primary response gene 88 Mus musculus 41-46 33681946-9 2021 CONCLUSION: miR-139-5p inhibits the TLR4/MyD88/NF-kappaB signaling pathway to alleviate acute lung injury in septic mice. mir-139-5p 12-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 47-56 33559815-0 2021 Correction to: MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. mir-139-5p 15-25 autocrine motility factor receptor Homo sapiens 97-101 33559815-0 2021 Correction to: MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. mir-139-5p 15-25 notch receptor 1 Homo sapiens 106-112 33247610-0 2021 MiR-139-5p Upregulation Alleviated Spontaneous Recurrent Epileptiform Discharge-induced Oxidative Stress and Apoptosis in Rat Hippocampal Neurons via Regulating the Notch Pathway. mir-139-5p 0-10 notch receptor 1 Rattus norvegicus 165-170 33247610-12 2021 Besides, Notch-1 overexpression reversed the effects of miR-139-5p upregulation on the expressions of Notch pathway-related proteins and apoptosis-related proteins, cell apoptosis, oxidative stress and MMP in SREDs-treated cells. mir-139-5p 56-66 notch receptor 1 Rattus norvegicus 9-16 33247610-12 2021 Besides, Notch-1 overexpression reversed the effects of miR-139-5p upregulation on the expressions of Notch pathway-related proteins and apoptosis-related proteins, cell apoptosis, oxidative stress and MMP in SREDs-treated cells. mir-139-5p 56-66 notch receptor 1 Rattus norvegicus 9-14 33247610-13 2021 Our results indicated that miR-139-5p upregulation alleviated SREDs-induced oxidative stress and cell apoptosis via regulating the Notch pathway, which provides new insights into the role of miRNA in the occurrence and development of epilepsy. mir-139-5p 27-37 notch receptor 1 Rattus norvegicus 131-136 33317757-15 2021 MiR-139-5p bound to ARF6 and inversely modulated the level of ARF6 in BC cells. mir-139-5p 0-10 ADP ribosylation factor 6 Homo sapiens 20-24 33317757-15 2021 MiR-139-5p bound to ARF6 and inversely modulated the level of ARF6 in BC cells. mir-139-5p 0-10 ADP ribosylation factor 6 Homo sapiens 62-66 33317757-16 2021 The transfection of si-ARF6 attenuated the promoting effects of miR-139-5p depletion on the migration, invasion, and EMT of BC cells treated with SEV. mir-139-5p 64-74 ADP ribosylation factor 6 Homo sapiens 23-27 33300085-0 2021 miR-139-5p enhances cisplatin sensitivity in non-small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox-B2. mir-139-5p 0-10 homeobox B2 Homo sapiens 156-179 33300085-11 2021 Additionally, miR-139-5p increased cell apoptosis and inhibited NSCLC cell proliferation induced by DDP in vitro via modulating the PI3K/AKT/caspase-3 signaling pathway. mir-139-5p 14-24 AKT serine/threonine kinase 1 Homo sapiens 137-140 33300085-11 2021 Additionally, miR-139-5p increased cell apoptosis and inhibited NSCLC cell proliferation induced by DDP in vitro via modulating the PI3K/AKT/caspase-3 signaling pathway. mir-139-5p 14-24 caspase 3 Homo sapiens 141-150 33211272-5 2021 Wild-type mice and Mst1(-/-) mice were exposed to SCI and treated with miR-139-5p agomir via intrathecal infusion. mir-139-5p 71-81 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 19-23 33211272-7 2021 Treatment with miR-139-5p enhanced phosphorylation of adenosine monophosphate-activated protein kinase alpha (AMPKalpha), improved mitochondrial function, and suppressed NF-kappaB-related inflammation in damaged spinal cords. mir-139-5p 15-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 170-179 33211272-10 2021 In conclusion, miR-139-5p treatment enhanced functional recovery and reduced pain hypersensitivity in mice with SCI, possibly through targeting Mst1. mir-139-5p 15-25 macrophage stimulating 1 (hepatocyte growth factor-like) Mus musculus 144-148 33552243-11 2021 Transfection of miR-139-5p inhibitor significantly reversed the inhibitory effect of SNHG3 knockdown on OVCAR3 proliferation and migration. mir-139-5p 16-26 small nucleolar RNA host gene 3 Homo sapiens 85-90 33552243-11 2021 Transfection of miR-139-5p inhibitor significantly reversed the inhibitory effect of SNHG3 knockdown on OVCAR3 proliferation and migration. mir-139-5p 16-26 carbonic anhydrase 3 Homo sapiens 104-110 33552243-12 2021 Moreover, SNHG3 inhibition or miR-139-5p mimic abolished the promotion of Notch1 overexpression on OVCAR3 proliferation and migration. mir-139-5p 30-40 notch receptor 1 Homo sapiens 74-80 33204298-0 2020 miR-139-5p Inhibits Lung Adenocarcinoma Cell Proliferation, Migration, and Invasion by Targeting MAD2L1. mir-139-5p 0-10 mitotic arrest deficient 2 like 1 Homo sapiens 97-103 33552243-12 2021 Moreover, SNHG3 inhibition or miR-139-5p mimic abolished the promotion of Notch1 overexpression on OVCAR3 proliferation and migration. mir-139-5p 30-40 carbonic anhydrase 3 Homo sapiens 99-105 33991848-12 2021 These findings were clinically validated by a positive correlation between RP3-439F8.1 and NR5A2 and a negative correlation between RP3-439F8.1 and miR-139-5p in GBM tumors. mir-139-5p 148-158 DNA segment, Roswell Park 3 Mus musculus 132-135 33331071-11 2021 miR-139-5p silencing antagonized the effects of EZH2 down-regulation on AS. mir-139-5p 0-10 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 48-52 33331071-12 2021 This study manifests that down-regulated EZH2 or elevated miR-139-5p inhibits ox-LDL-induced HASMCs apoptosis, plaque formation, and inflammatory response in AS mice, which may be related to down-regulated STAT1. mir-139-5p 58-68 signal transducer and activator of transcription 1 Mus musculus 206-211 33204298-6 2020 A dual-luciferase reporter gene assay was conducted to verify the direct targeting relationship between miR-139-5p and MAD2L1. mir-139-5p 104-114 mitotic arrest deficient 2 like 1 Homo sapiens 119-125 33204298-10 2020 Besides, the inhibitory effect of miR-139-5p overexpression on LUAD cell proliferation, migration, and invasion was attenuated by overexpressing MAD2L1. mir-139-5p 34-44 mitotic arrest deficient 2 like 1 Homo sapiens 145-151 33204298-11 2020 Conclusion: Our study suggests that miR-139-5p is lowly expressed in LUAD cells and inhibits LUAD cell proliferation, migration, and invasion by targeted suppressing MAD2L1 expression. mir-139-5p 36-46 mitotic arrest deficient 2 like 1 Homo sapiens 166-172 32734536-11 2020 The tumor-promoting effects of LINC00324 were attenuated through miR-139-5p overexpression. mir-139-5p 65-75 long intergenic non-protein coding RNA 324 Homo sapiens 31-40 33293476-5 2020 MiR-139-5p mimics inhibited tube formation, migration, proliferation, and down-regulated expression of c-jun, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-B, in ECFCs and HUVECs, respectively; moreover, miR-139-5p inhibitors reversed the tendency. mir-139-5p 0-10 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 33293476-5 2020 MiR-139-5p mimics inhibited tube formation, migration, proliferation, and down-regulated expression of c-jun, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-B, in ECFCs and HUVECs, respectively; moreover, miR-139-5p inhibitors reversed the tendency. mir-139-5p 0-10 vascular endothelial growth factor A Homo sapiens 110-144 33293476-5 2020 MiR-139-5p mimics inhibited tube formation, migration, proliferation, and down-regulated expression of c-jun, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-B, in ECFCs and HUVECs, respectively; moreover, miR-139-5p inhibitors reversed the tendency. mir-139-5p 0-10 vascular endothelial growth factor A Homo sapiens 146-150 33293476-5 2020 MiR-139-5p mimics inhibited tube formation, migration, proliferation, and down-regulated expression of c-jun, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-B, in ECFCs and HUVECs, respectively; moreover, miR-139-5p inhibitors reversed the tendency. mir-139-5p 0-10 platelet derived growth factor subunit B Homo sapiens 157-196 33293476-5 2020 MiR-139-5p mimics inhibited tube formation, migration, proliferation, and down-regulated expression of c-jun, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF)-B, in ECFCs and HUVECs, respectively; moreover, miR-139-5p inhibitors reversed the tendency. mir-139-5p 243-253 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 103-108 33293476-6 2020 Further, gain- and-loss function experiments and ChIP assay indicated that miR-139-5p regulate functions of ECFCs by targeting c-jun-VEGF/PDGF-B pathway. mir-139-5p 75-85 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 127-132 33293476-6 2020 Further, gain- and-loss function experiments and ChIP assay indicated that miR-139-5p regulate functions of ECFCs by targeting c-jun-VEGF/PDGF-B pathway. mir-139-5p 75-85 vascular endothelial growth factor A Homo sapiens 133-137 33293476-6 2020 Further, gain- and-loss function experiments and ChIP assay indicated that miR-139-5p regulate functions of ECFCs by targeting c-jun-VEGF/PDGF-B pathway. mir-139-5p 75-85 platelet derived growth factor subunit B Homo sapiens 138-144 33293476-8 2020 In conclusion, diabetes-mediated high miR-139-5p expression inhibits the c-jun-VEGF/PDGF-B pathway, thus decreasing ECFCs migration, tube formation and proliferation, which subsequently reduces ECs survival. mir-139-5p 38-48 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 73-78 33293476-8 2020 In conclusion, diabetes-mediated high miR-139-5p expression inhibits the c-jun-VEGF/PDGF-B pathway, thus decreasing ECFCs migration, tube formation and proliferation, which subsequently reduces ECs survival. mir-139-5p 38-48 vascular endothelial growth factor A Homo sapiens 79-83 33293476-8 2020 In conclusion, diabetes-mediated high miR-139-5p expression inhibits the c-jun-VEGF/PDGF-B pathway, thus decreasing ECFCs migration, tube formation and proliferation, which subsequently reduces ECs survival. mir-139-5p 38-48 platelet derived growth factor subunit B Homo sapiens 84-90 32852921-0 2020 MiR-139-5p alleviates neural cell apoptosis induced by spinal cord injury through targeting TRAF3. mir-139-5p 0-10 Tnf receptor-associated factor 3 Rattus norvegicus 92-97 32852921-8 2020 Therefore, TRAF3 mediated the anti-apoptosis effect of miR-139-5p in SCI rats and miR-139-5p could be a promising candidate for SCI therapy by alleviating neural cell apoptosis through targeting TRAF3. mir-139-5p 55-65 Tnf receptor-associated factor 3 Rattus norvegicus 11-16 32852921-8 2020 Therefore, TRAF3 mediated the anti-apoptosis effect of miR-139-5p in SCI rats and miR-139-5p could be a promising candidate for SCI therapy by alleviating neural cell apoptosis through targeting TRAF3. mir-139-5p 55-65 Tnf receptor-associated factor 3 Rattus norvegicus 195-200 32852921-8 2020 Therefore, TRAF3 mediated the anti-apoptosis effect of miR-139-5p in SCI rats and miR-139-5p could be a promising candidate for SCI therapy by alleviating neural cell apoptosis through targeting TRAF3. mir-139-5p 82-92 Tnf receptor-associated factor 3 Rattus norvegicus 195-200 32913469-8 2020 Importantly, overexpression of miR-139-5p blocked Notch1 pathway activation and inhibited EMT event in PM2.5 treated cells. mir-139-5p 31-41 notch receptor 1 Homo sapiens 50-56 32913469-8 2020 Importantly, overexpression of miR-139-5p blocked Notch1 pathway activation and inhibited EMT event in PM2.5 treated cells. mir-139-5p 31-41 IL2 inducible T cell kinase Homo sapiens 90-93 32764976-0 2020 miR-139-5p Regulates Proliferation, Apoptosis, and Cell Cycle of Uterine Leiomyoma Cells by Targeting TPD52 [Expression of Concern]. mir-139-5p 0-10 tumor protein D52 Homo sapiens 102-107 32006899-11 2020 Downregulation of miR-139-5p or upregulation of ROCK2 partially rescued the inhibitory impact of TTN-AS1 knockdown on OC cells. mir-139-5p 18-28 TTN antisense RNA 1 Homo sapiens 97-104 32507766-7 2020 Additionally, we show that suppression NOTCH1 by miR-139-5p could be partially rescued by overexpressing RP11-59H7.3. mir-139-5p 49-59 notch receptor 1 Homo sapiens 39-45 32507766-7 2020 Additionally, we show that suppression NOTCH1 by miR-139-5p could be partially rescued by overexpressing RP11-59H7.3. mir-139-5p 49-59 pre-mRNA processing factor 31 Homo sapiens 105-109 32641995-7 2020 Results: miR-139-5p was significantly downregulated in KRAS-mutated CRC cells and tissues compared with their wild-type counterparts. mir-139-5p 9-19 KRAS proto-oncogene, GTPase Homo sapiens 55-59 32641995-12 2020 Conclusions: We identified miR-139-5p as a KRAS-responsive miRNA and demonstrated its involvement in CRC progression. mir-139-5p 27-37 KRAS proto-oncogene, GTPase Homo sapiens 43-47 32109492-6 2020 RESULTS: MiR-139-5p could regulate and affect the protein expression of P13K and Akt associated with phosphatidylinositol signaling pathway by inhibiting SLC7A11. mir-139-5p 9-19 AKT serine/threonine kinase 1 Homo sapiens 81-84 32109492-6 2020 RESULTS: MiR-139-5p could regulate and affect the protein expression of P13K and Akt associated with phosphatidylinositol signaling pathway by inhibiting SLC7A11. mir-139-5p 9-19 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 154-161 32109492-11 2020 Therefore, the inhibitory of miR-139-5p to PANC cell proliferation, invasion and metastasis was partly due to its inhibiting effect on SLC7A11 expression. mir-139-5p 29-39 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 135-142 32472755-1 2020 miR-139-5p has a tumor suppressor effect in some cancers and negatively regulates CXCR4. mir-139-5p 0-10 C-X-C motif chemokine receptor 4 Homo sapiens 82-87 32472755-5 2020 Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4. mir-139-5p 18-28 MYC proto-oncogene, bHLH transcription factor Homo sapiens 164-169 32472755-5 2020 Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4. mir-139-5p 18-28 cyclin D1 Homo sapiens 171-179 32472755-5 2020 Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4. mir-139-5p 18-28 BCL2 apoptosis regulator Homo sapiens 185-190 32472755-5 2020 Overexpression of miR-139-5p in OSCC inhibited in vitro and in vivo cell proliferation and in vitro mobility of OSCC and inhibited the expression of WNT responsive c-myc, cyclinD1, and Bcl-2, and such effects were all reversible by an inhibitor of miR-139-5p or over-expression of CXCR4. mir-139-5p 18-28 C-X-C motif chemokine receptor 4 Homo sapiens 281-286 32327260-0 2020 MiR-139-5p inhibits the proliferation of gastric cancer cells by targeting Regulation of Nuclear Pre-mRNA Domain Containing 1B. mir-139-5p 0-10 regulation of nuclear pre-mRNA domain containing 1B Homo sapiens 75-126 32327260-10 2020 We demonstrated that the ability of miR-139-5p to regulate GC cell proliferation depends on RPRD1B. mir-139-5p 36-46 regulation of nuclear pre-mRNA domain containing 1B Homo sapiens 92-98 32194674-7 2020 Rescue experiments demonstrated that the inhibitory function of miR-139-5p on cell viability, migration and invasion was partially mediated by suppressing HDGF expression. mir-139-5p 64-74 heparin binding growth factor Homo sapiens 155-159 32293663-0 2020 Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway. mir-139-5p 17-27 notch 1 Mus musculus 116-121 32256083-13 2020 Downregulation of miR-139-5p reversed the effects of TUG1 deletion on proliferation, apoptosis and colony survival fraction in PCa cells treated with 4 Gy of X-ray radiation. mir-139-5p 18-28 taurine up-regulated 1 Homo sapiens 53-57 32103995-11 2020 MiR-139-5p was found to target ROCK1 directly, leading to suppression of ROCK1 expression; this effect could be partially reversed by inhibiting XIST expression. mir-139-5p 0-10 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 31-36 32109290-0 2020 SLC39A7, regulated by miR-139-5p, induces cell proliferation, migration and inhibits apoptosis in gastric cancer via Akt/mTOR signaling pathway. mir-139-5p 22-32 solute carrier family 39 member 7 Homo sapiens 0-7 32109290-7 2020 miR-139-5p mimic had adverse effects on SLC39A7 expression and influence in the GC cell proliferation, migration and apoptosis by Akt/mTOR signaling pathway, while miR-139-5p inhibitor showed opposite effects. mir-139-5p 0-10 solute carrier family 39 member 7 Homo sapiens 40-47 32109290-7 2020 miR-139-5p mimic had adverse effects on SLC39A7 expression and influence in the GC cell proliferation, migration and apoptosis by Akt/mTOR signaling pathway, while miR-139-5p inhibitor showed opposite effects. mir-139-5p 0-10 AKT serine/threonine kinase 1 Homo sapiens 130-133 32109290-7 2020 miR-139-5p mimic had adverse effects on SLC39A7 expression and influence in the GC cell proliferation, migration and apoptosis by Akt/mTOR signaling pathway, while miR-139-5p inhibitor showed opposite effects. mir-139-5p 0-10 mechanistic target of rapamycin kinase Homo sapiens 134-138 32103995-11 2020 MiR-139-5p was found to target ROCK1 directly, leading to suppression of ROCK1 expression; this effect could be partially reversed by inhibiting XIST expression. mir-139-5p 0-10 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 73-78 32103995-11 2020 MiR-139-5p was found to target ROCK1 directly, leading to suppression of ROCK1 expression; this effect could be partially reversed by inhibiting XIST expression. mir-139-5p 0-10 X inactive specific transcript Homo sapiens 145-149 31894289-0 2020 miR-139-5p affects cell proliferation, migration and adipogenesis by targeting insulin-like growth factor 1 receptor in hemangioma stem cells. mir-139-5p 0-10 insulin like growth factor 1 receptor Homo sapiens 79-116 32174796-0 2020 MiR-139-5p negatively regulates PMP22 to repress cell proliferation by targeting the NF-kappaB signaling pathway in gastric cancer. mir-139-5p 0-10 peripheral myelin protein 22 Mus musculus 32-37 32174796-8 2020 Mechanistically, miR-139-5p may negatively regulate PMP22 to repress cell proliferation by targeting the NF-kappaB signaling pathway in gastric cancer. mir-139-5p 17-27 peripheral myelin protein 22 Mus musculus 52-57 31894289-12 2020 Overall, miR-139-5p is able to affect the IGF-1/IGF-1R pathway by regulating IGF-1R expression, which ultimately affects the proliferation, migration and adipogenesis of HemSCs. mir-139-5p 9-19 insulin like growth factor 1 Homo sapiens 42-47 31894289-12 2020 Overall, miR-139-5p is able to affect the IGF-1/IGF-1R pathway by regulating IGF-1R expression, which ultimately affects the proliferation, migration and adipogenesis of HemSCs. mir-139-5p 9-19 insulin like growth factor 1 receptor Homo sapiens 48-54 31894289-12 2020 Overall, miR-139-5p is able to affect the IGF-1/IGF-1R pathway by regulating IGF-1R expression, which ultimately affects the proliferation, migration and adipogenesis of HemSCs. mir-139-5p 9-19 insulin like growth factor 1 receptor Homo sapiens 77-83 31894289-8 2020 miR-139-5p overexpression reduced IGF-1R expression, and miR-139-5p inhibition increased IGF-1R expression. mir-139-5p 0-10 insulin like growth factor 1 receptor Homo sapiens 34-40 31894289-8 2020 miR-139-5p overexpression reduced IGF-1R expression, and miR-139-5p inhibition increased IGF-1R expression. mir-139-5p 57-67 insulin like growth factor 1 receptor Homo sapiens 89-95 31187495-6 2019 Furthermore, the positive correlation of LINC01579 and EIF4G2 as well as the converse correlation between miR-139-5p and LINC01579 (or EIF4G2) were revealed by the experiments. mir-139-5p 106-116 long intergenic non-protein coding RNA 1579 Homo sapiens 121-130 31758243-11 2020 FOXD2-AS1 knockdown induced a marked increase in miR-139-5p and EMT inhibition. mir-139-5p 49-59 forkhead box D2 Homo sapiens 0-5 31758243-11 2020 FOXD2-AS1 knockdown induced a marked increase in miR-139-5p and EMT inhibition. mir-139-5p 49-59 prostaglandin D2 receptor Homo sapiens 6-9 31758243-13 2020 Conversely, miR-139-5p overexpression suppressed BLVRA and CYTH expression and EMT process. mir-139-5p 12-22 biliverdin reductase A Homo sapiens 49-54 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 25-35 myocardial infarction associated transcript Homo sapiens 40-44 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 25-35 myocardial infarction associated transcript Homo sapiens 130-134 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 25-35 matrix metallopeptidase 2 Homo sapiens 209-213 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 160-170 myocardial infarction associated transcript Homo sapiens 40-44 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 160-170 matrix metallopeptidase 2 Homo sapiens 48-52 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 160-170 myocardial infarction associated transcript Homo sapiens 130-134 32345777-7 2020 The relationship between miR-139-5p and MIAT or MMP2 was then confirmed by Luciferase reporter assay, and the results showed that MIAT directly interacted with miR-139-5p and miR-139- 5p targetedly suppressed MMP2 in NSCLC cells. mir-139-5p 160-170 matrix metallopeptidase 2 Homo sapiens 209-213 32345777-9 2020 Finally, rescue assay suggested that miR-139-5p restoration reversed MIAT-overexpression-induced promotion on the migration and invasion of NSCLC cells. mir-139-5p 37-47 myocardial infarction associated transcript Homo sapiens 69-73 31187495-6 2019 Furthermore, the positive correlation of LINC01579 and EIF4G2 as well as the converse correlation between miR-139-5p and LINC01579 (or EIF4G2) were revealed by the experiments. mir-139-5p 106-116 eukaryotic translation initiation factor 4 gamma 2 Homo sapiens 135-141 31187495-7 2019 Based on rescue assays, EIF4G2 overexpression or miR-139-5p inhibitor partially recovered the function of LINC01579 knockdown on cell proliferation and apoptosis. mir-139-5p 49-59 long intergenic non-protein coding RNA 1579 Homo sapiens 106-115 31120140-0 2019 miR-139-5p reverses stemness maintenance and metastasis of colon cancer stem-like cells by targeting E2-2. mir-139-5p 0-10 transcription factor 4 Homo sapiens 101-105 31120140-4 2019 This research discovered that miR-139-5p targets the Wnt/beta-catenin/TCF7L2 downstream effector E2-2 in CCSCs. mir-139-5p 30-40 catenin beta 1 Homo sapiens 57-69 31120140-4 2019 This research discovered that miR-139-5p targets the Wnt/beta-catenin/TCF7L2 downstream effector E2-2 in CCSCs. mir-139-5p 30-40 transcription factor 7 like 2 Homo sapiens 70-76 31120140-4 2019 This research discovered that miR-139-5p targets the Wnt/beta-catenin/TCF7L2 downstream effector E2-2 in CCSCs. mir-139-5p 30-40 transcription factor 4 Homo sapiens 97-101 31120140-7 2019 This study provides a theoretical foundation for the clinical diagnosis and medical treatment of recurrent or metastatic colon cancer with miR-139-5p and its target E2-2. mir-139-5p 139-149 transcription factor 4 Homo sapiens 165-169 30367526-4 2019 Luciferase reporter assay, qRT-PCR, and Western blot analysis were carried out to detect the interaction between miR-139-5p and Tspan3. mir-139-5p 113-123 tetraspanin 3 Homo sapiens 128-134 31516562-0 2019 Downregulation of thymopoietin by miR-139-5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma. mir-139-5p 34-44 thymopoietin Homo sapiens 18-30 30710422-0 2019 MiR-139-5p, miR-940 and miR-193a-5p inhibit the growth of hepatocellular carcinoma by targeting SPOCK1. mir-139-5p 0-10 sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 Mus musculus 96-102 32233587-5 2019 RNA binding protein immunoprecipitation assay was employed to test the targeted relationship between miR-139-5p and COL11A1, which was further verified by dual-luciferase reporter gene assay. mir-139-5p 101-111 collagen type XI alpha 1 chain Homo sapiens 116-123 32233587-9 2019 According to the database analysis, we predicted that miR-139-5p was much likely to target the expression of COL11A1. mir-139-5p 54-64 collagen type XI alpha 1 chain Homo sapiens 109-116 32233587-10 2019 MiR-139-5p was poorly expressed in breast cancer cells and targeted inhibited COL11A1. mir-139-5p 0-10 collagen type XI alpha 1 chain Homo sapiens 78-85 31258024-0 2019 Up-regulation of SNHG6 activates SERPINH1 expression by competitive binding to miR-139-5p to promote hepatocellular carcinoma progression. mir-139-5p 79-89 small nucleolar RNA host gene 6 Homo sapiens 17-22 31258024-0 2019 Up-regulation of SNHG6 activates SERPINH1 expression by competitive binding to miR-139-5p to promote hepatocellular carcinoma progression. mir-139-5p 79-89 serpin family H member 1 Homo sapiens 33-41 30367526-10 2019 In addition, we found that miR-139-5p suppressed the phosphoinositide 3-kinase (PI3K)/Akt pathway in AML cells by targeting Tspan3. mir-139-5p 27-37 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 53-78 30367526-10 2019 In addition, we found that miR-139-5p suppressed the phosphoinositide 3-kinase (PI3K)/Akt pathway in AML cells by targeting Tspan3. mir-139-5p 27-37 AKT serine/threonine kinase 1 Homo sapiens 86-89 30367526-10 2019 In addition, we found that miR-139-5p suppressed the phosphoinositide 3-kinase (PI3K)/Akt pathway in AML cells by targeting Tspan3. mir-139-5p 27-37 tetraspanin 3 Homo sapiens 124-130 30367526-11 2019 In conclusion, our study concluded that miR-139-5p suppressed the leukemogenesis in AML cells by targeting Tspan3 through inactivation of the PI3K/Akt pathway, providing a better understanding of AML progression. mir-139-5p 40-50 tetraspanin 3 Homo sapiens 107-113 30367526-11 2019 In conclusion, our study concluded that miR-139-5p suppressed the leukemogenesis in AML cells by targeting Tspan3 through inactivation of the PI3K/Akt pathway, providing a better understanding of AML progression. mir-139-5p 40-50 AKT serine/threonine kinase 1 Homo sapiens 147-150 30796202-10 2019 Mechanistically, we confirmed that circBACH2 could directly bind to miR-139-5p and relieve suppression of the target LMO4. mir-139-5p 68-78 LIM domain only 4 Homo sapiens 117-121 30899394-9 2019 Dual-luciferase assay was performed to measure miR-139-5p-targeted relationship with lncRNA HCP5. mir-139-5p 47-57 HLA complex P5 Homo sapiens 92-96 30899394-12 2019 Moreover, luciferase reporter assay demonstrated that miR-139-5p was a directly target of HCP5 (P < 0.05). mir-139-5p 54-64 HLA complex P5 Homo sapiens 90-94 29478280-8 2018 We investigated the role of miR-139-5p in regulating PI3K/AKT signalling by the use of human cell cultures derived from supratentorial pLGGs. mir-139-5p 28-38 AKT serine/threonine kinase 1 Homo sapiens 58-61 30245290-0 2019 MiR-139-5p regulates VEGFR and downstream signaling pathways to inhibit the development of esophageal cancer. mir-139-5p 0-10 kinase insert domain receptor Homo sapiens 21-26 30245290-11 2019 MiR-139-5p expression in the serum of 92 patients with esophageal cancer was associated with gender (P = 0.039) and TNM stage (P = 0.015). mir-139-5p 0-10 teneurin transmembrane protein 1 Homo sapiens 116-119 30245290-18 2019 Upregulation of miR-139-5p inhibited the expression of Cyclin D1 and VEGFR-1 and increased the expression of E-cadherin. mir-139-5p 16-26 cyclin D1 Homo sapiens 55-64 30245290-18 2019 Upregulation of miR-139-5p inhibited the expression of Cyclin D1 and VEGFR-1 and increased the expression of E-cadherin. mir-139-5p 16-26 fms related receptor tyrosine kinase 1 Homo sapiens 69-76 30245290-18 2019 Upregulation of miR-139-5p inhibited the expression of Cyclin D1 and VEGFR-1 and increased the expression of E-cadherin. mir-139-5p 16-26 cadherin 1 Homo sapiens 109-119 30551470-9 2019 Our study indicated that miR-139-5p functioned as a tumor suppressor in prostate cancer cells by regulation of SOX5, and it might be a promising target for prostate cancer patients. mir-139-5p 25-35 SRY-box transcription factor 5 Homo sapiens 111-115 29478280-10 2018 The effect of miR-139-5p was mediated by PI3K inhibition, as suggested by the decrease in proliferation and phosphorylation of AKT and p70 S6K after treatment with the direct PI3K inhibitor LY294002. mir-139-5p 14-24 AKT serine/threonine kinase 1 Homo sapiens 127-130 29478280-10 2018 The effect of miR-139-5p was mediated by PI3K inhibition, as suggested by the decrease in proliferation and phosphorylation of AKT and p70 S6K after treatment with the direct PI3K inhibitor LY294002. mir-139-5p 14-24 ribosomal protein S6 kinase B1 Homo sapiens 135-142 29916183-8 2018 These findings suggested that miR-139-5p was involved in regulating chronic morphine-induced, naloxone-precipitated cAMP overshoot in a negative feedback manner through its target c-Jun, which extends our understanding of neurobiological mechanisms underlying morphine dependence and addiction. mir-139-5p 30-40 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 180-185 30304920-5 2018 Dual-luciferase report gene assay and chromatin immunoprecipitation assay were employed to identify the relationship between miR-139-5p and EZH2. mir-139-5p 125-135 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens 140-144 30304920-9 2018 EZH2 suppressed the expression of miR-139-5p through up-regulating Histone 3 Lysine 27 Trimethylation (H3K27me3). mir-139-5p 34-44 enhancer of zeste 2 polycomb repressive complex 2 subunit Homo sapiens 0-4 30153566-7 2018 The combination of miR-139-5p and yuanhuadine, a naturally derived antitumor agent, synergistically suppressed BMP4 expression in the resistant cells. mir-139-5p 19-29 bone morphogenetic protein 4 Mus musculus 111-115 29673587-0 2018 MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1. mir-139-5p 0-10 DNA methyltransferase 1 Homo sapiens 79-84 29673587-6 2018 The relationship between miR-139-5p and DNMT1was explored using luciferase reporter analysis and western blot. mir-139-5p 25-35 DNA methyltransferase 1 Homo sapiens 40-45 29673587-11 2018 MiR-139-5p regulated a down-regulation in DNMT1 protein expression levels. mir-139-5p 0-10 DNA methyltransferase 1 Homo sapiens 42-47 29673587-14 2018 CONCLUSION: MiR-139-5p suppressed the osteosarcoma progression by reducing DNMT1, supplying new insight into the molecular mechanism uncovering osteosarcoma growth. mir-139-5p 12-22 DNA methyltransferase 1 Homo sapiens 75-80 29705696-8 2018 Furthermore, treatment of phenylephrine (PE), a alpha1-adrenoceptor agonist, abolished the inhibitory effect of miR-139-5p on MyHC I and MyHC IIa expression. mir-139-5p 112-122 myosin, heavy polypeptide 7, cardiac muscle, beta Mus musculus 126-132 29705696-6 2018 Overexpression of miR-139-5p downregulated the expression of MyHC I and MyHC IIa, whereas inhibition of miR-139-5p upregulated them. mir-139-5p 18-28 myosin, heavy polypeptide 7, cardiac muscle, beta Mus musculus 61-67 29705696-6 2018 Overexpression of miR-139-5p downregulated the expression of MyHC I and MyHC IIa, whereas inhibition of miR-139-5p upregulated them. mir-139-5p 18-28 myosin, heavy polypeptide 2, skeletal muscle, adult Mus musculus 72-80 29240250-1 2018 The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. mir-139-5p 27-37 lysophosphatidic acid receptor 4 Homo sapiens 48-53 29240250-1 2018 The study explores whether miR-139-5p targeting LPAR4 affects epithelial-mesenchymal transition (EMT) and fibrosis in post-menopausal women with interstitial cystitis (IC) via the PI3K/Akt signaling pathway. mir-139-5p 27-37 AKT serine/threonine kinase 1 Homo sapiens 185-188 29240250-14 2018 The miR-139-5p decreased in the miR-139-5p inhibitor + siRNA-LPAR4 and miR-139-5p inhibitor + wortmannin groups. mir-139-5p 4-14 lysophosphatidic acid receptor 4 Homo sapiens 61-66 29240250-14 2018 The miR-139-5p decreased in the miR-139-5p inhibitor + siRNA-LPAR4 and miR-139-5p inhibitor + wortmannin groups. mir-139-5p 32-42 lysophosphatidic acid receptor 4 Homo sapiens 61-66 29240250-14 2018 The miR-139-5p decreased in the miR-139-5p inhibitor + siRNA-LPAR4 and miR-139-5p inhibitor + wortmannin groups. mir-139-5p 32-42 lysophosphatidic acid receptor 4 Homo sapiens 61-66 29240250-15 2018 Conclusively, miR-139-5p targeting LPAR4 inhibits EMT and fibrosis in post-menopausal IC women through the PI3K/Akt signaling pathway. mir-139-5p 14-24 lysophosphatidic acid receptor 4 Homo sapiens 35-40 29240250-15 2018 Conclusively, miR-139-5p targeting LPAR4 inhibits EMT and fibrosis in post-menopausal IC women through the PI3K/Akt signaling pathway. mir-139-5p 14-24 AKT serine/threonine kinase 1 Homo sapiens 112-115 29705696-8 2018 Furthermore, treatment of phenylephrine (PE), a alpha1-adrenoceptor agonist, abolished the inhibitory effect of miR-139-5p on MyHC I and MyHC IIa expression. mir-139-5p 112-122 myosin, heavy polypeptide 2, skeletal muscle, adult Mus musculus 137-145 29705696-9 2018 Together, our findings indicated that the role of miR-139-5p in regulating the MyHC isoforms, especially MyHC I and MyHC IIa, may be achieved through inhibiting CaN/NFAT signaling pathway. mir-139-5p 50-60 myosin heavy chain, cardiac muscle complex Mus musculus 79-83 29705696-9 2018 Together, our findings indicated that the role of miR-139-5p in regulating the MyHC isoforms, especially MyHC I and MyHC IIa, may be achieved through inhibiting CaN/NFAT signaling pathway. mir-139-5p 50-60 myosin, heavy polypeptide 7, cardiac muscle, beta Mus musculus 105-111 29705696-9 2018 Together, our findings indicated that the role of miR-139-5p in regulating the MyHC isoforms, especially MyHC I and MyHC IIa, may be achieved through inhibiting CaN/NFAT signaling pathway. mir-139-5p 50-60 myosin, heavy polypeptide 2, skeletal muscle, adult Mus musculus 116-124 28780773-0 2017 MiR-139-5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9. mir-139-5p 0-10 homeobox A9 Homo sapiens 100-105 28653604-10 2018 Rescue experiments showed that overexpression of ROCK2 effectively reversed the inhibitory effect of OC cells induced by miR-139-5p. mir-139-5p 121-131 Rho associated coiled-coil containing protein kinase 2 Homo sapiens 49-54 29393392-8 2018 We demonstrated that miR-139-5p inhibited the Flt1-mediated Wnt/beta-catenin signaling pathway in glioma cells. mir-139-5p 21-31 fms related receptor tyrosine kinase 1 Homo sapiens 46-50 29393392-8 2018 We demonstrated that miR-139-5p inhibited the Flt1-mediated Wnt/beta-catenin signaling pathway in glioma cells. mir-139-5p 21-31 catenin beta 1 Homo sapiens 64-76 29393392-9 2018 Conclusively, our study indicated that miR-139-5p can counteract the malignant phenotypes of glioma cells by the inhibitory effect of the Flt1-mediated Wnt/beta-catenin signaling pathway. mir-139-5p 39-49 fms related receptor tyrosine kinase 1 Homo sapiens 138-142 29393392-9 2018 Conclusively, our study indicated that miR-139-5p can counteract the malignant phenotypes of glioma cells by the inhibitory effect of the Flt1-mediated Wnt/beta-catenin signaling pathway. mir-139-5p 39-49 catenin beta 1 Homo sapiens 156-168 29440459-0 2018 miR-139-5p inhibits isoproterenol-induced cardiac hypertrophy by targetting c-Jun. mir-139-5p 0-10 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 76-81 29440459-7 2018 Overexpression of miR-139-5p antagonized isoproterenol (ISO)-induced cardiomyocyte enlargement and ANP/brain natriuretic peptide (BNP) up-regulation. mir-139-5p 18-28 natriuretic peptide B Homo sapiens 99-128 29440459-7 2018 Overexpression of miR-139-5p antagonized isoproterenol (ISO)-induced cardiomyocyte enlargement and ANP/brain natriuretic peptide (BNP) up-regulation. mir-139-5p 18-28 natriuretic peptide B Homo sapiens 130-133 29440459-9 2018 Knockdown of c-Jun expression significantly attenuated cardiac hypertrophy induced by miR-139-5p deprivation. mir-139-5p 86-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 29156518-5 2018 Our results revealed that miR-139-5p inhibited glycolysis by regulating AMP-activated, alpha 1 catalytic subunit (PRKAA1) expression in gastric cancer cells. mir-139-5p 26-36 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 114-120 30439707-0 2018 Recovery of miR-139-5p in Ovarian Cancer Reverses Cisplatin Resistance by Targeting C-Jun. mir-139-5p 12-22 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 84-89 30439707-11 2018 Recovery of miR-139-5p increased the sensitivity of SKOV3-R and A2780-R cells to cisplatin treatment, inhibited the interaction of c-Jun and ATF2, and decreased Bcl-xl expression in SKOV3-R and A2780-R cells. mir-139-5p 12-22 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 131-136 30439707-11 2018 Recovery of miR-139-5p increased the sensitivity of SKOV3-R and A2780-R cells to cisplatin treatment, inhibited the interaction of c-Jun and ATF2, and decreased Bcl-xl expression in SKOV3-R and A2780-R cells. mir-139-5p 12-22 activating transcription factor 2 Homo sapiens 141-145 30439707-11 2018 Recovery of miR-139-5p increased the sensitivity of SKOV3-R and A2780-R cells to cisplatin treatment, inhibited the interaction of c-Jun and ATF2, and decreased Bcl-xl expression in SKOV3-R and A2780-R cells. mir-139-5p 12-22 BCL2 like 1 Homo sapiens 161-167 30439707-13 2018 CONCLUSION: Recovery of miR-139-5p suppressed the expression of c-Jun and thus reversed cisplatin-resistance in ovarian cancer. mir-139-5p 24-34 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 64-69 28780773-5 2017 The target relationship between miR-139-5p and HOXA9 was verified by luciferase reporter assay and Western blot, respectively. mir-139-5p 32-42 homeobox A9 Homo sapiens 47-52 28780773-10 2017 Our results indicated that miR-139-5p could directly inhibit HOXA9, which might be a potential mechanism in inhibiting the proliferation, invasiveness and migration of OSCC cells. mir-139-5p 27-37 homeobox A9 Homo sapiens 61-66 28711603-0 2017 MiR-139-5p inhibits proliferation and promoted apoptosis of human airway smooth muscle cells by downregulating the Brg1 gene. mir-139-5p 0-10 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 115-119 28711603-6 2017 Ectopic expression of Brg1 partially reversed the effect of miR-139-5p on cell proliferation and apoptosis. mir-139-5p 60-70 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 22-26 28711603-7 2017 Moreover, overexpression of Brg1 restored miR-139-5p-induced downregulation of Akt and p70S6K phosphorylation. mir-139-5p 42-52 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 28-32 28711603-7 2017 Moreover, overexpression of Brg1 restored miR-139-5p-induced downregulation of Akt and p70S6K phosphorylation. mir-139-5p 42-52 AKT serine/threonine kinase 1 Homo sapiens 79-82 28711603-7 2017 Moreover, overexpression of Brg1 restored miR-139-5p-induced downregulation of Akt and p70S6K phosphorylation. mir-139-5p 42-52 ribosomal protein S6 kinase B1 Homo sapiens 87-93 28622009-0 2017 miR-139-5p Represses BMSC Osteogenesis via Targeting Wnt/beta-Catenin Signaling Pathway. mir-139-5p 0-10 catenin beta 1 Homo sapiens 57-69 28622009-8 2017 miR-139-5p exerts its role in BMSC osteogenesis most probably through the Wnt/beta-catenin pathway, by direct targeting CTNNB1 and frizzled 4 (FZD4), essential factors of Wnt/beta-catenin pathway. mir-139-5p 0-10 catenin beta 1 Homo sapiens 78-90 28622009-8 2017 miR-139-5p exerts its role in BMSC osteogenesis most probably through the Wnt/beta-catenin pathway, by direct targeting CTNNB1 and frizzled 4 (FZD4), essential factors of Wnt/beta-catenin pathway. mir-139-5p 0-10 catenin beta 1 Homo sapiens 120-126 28622009-8 2017 miR-139-5p exerts its role in BMSC osteogenesis most probably through the Wnt/beta-catenin pathway, by direct targeting CTNNB1 and frizzled 4 (FZD4), essential factors of Wnt/beta-catenin pathway. mir-139-5p 0-10 frizzled class receptor 4 Homo sapiens 131-141 28622009-8 2017 miR-139-5p exerts its role in BMSC osteogenesis most probably through the Wnt/beta-catenin pathway, by direct targeting CTNNB1 and frizzled 4 (FZD4), essential factors of Wnt/beta-catenin pathway. mir-139-5p 0-10 frizzled class receptor 4 Homo sapiens 143-147 28622009-8 2017 miR-139-5p exerts its role in BMSC osteogenesis most probably through the Wnt/beta-catenin pathway, by direct targeting CTNNB1 and frizzled 4 (FZD4), essential factors of Wnt/beta-catenin pathway. mir-139-5p 0-10 catenin beta 1 Homo sapiens 175-187 28346520-0 2017 Downregulation of miR-139-5p contributes to the antiapoptotic effect of liraglutide on the diabetic rat pancreas and INS-1 cells by targeting IRS1. mir-139-5p 18-28 insulin receptor substrate 1 Rattus norvegicus 142-146 28720065-2 2017 Here, we report that miR-139-5p functions as a tumor suppressor in bladder cancer and inhibits the cancer stem cell self-renewal by targeting Bmi1 directly. mir-139-5p 21-31 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 142-146 28720065-5 2017 Mechanism analysis revealed that miR-139-5p could decrease Bmi1 protein levels by binding to the 3" untranslated region of Bmi1 messenger RNA. mir-139-5p 33-43 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 59-63 28720065-5 2017 Mechanism analysis revealed that miR-139-5p could decrease Bmi1 protein levels by binding to the 3" untranslated region of Bmi1 messenger RNA. mir-139-5p 33-43 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 123-127 28346520-12 2017 Direct regulatory effects of miR-139-5p on IRS1 were found by a dual-luciferase reporter assay. mir-139-5p 29-39 insulin receptor substrate 1 Rattus norvegicus 43-47 27633066-6 2016 In vitro, it has been discovered that treatment of HCC cells with a miR-139-5p mimic lead to inhibition of cell growth and migration. mir-139-5p 68-78 HCC Homo sapiens 51-54 28231734-6 2017 PDK1 was identified as a direct target of miR-139-5p. mir-139-5p 42-52 pyruvate dehydrogenase kinase 1 Homo sapiens 0-4 27738333-0 2016 MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells. mir-139-5p 0-10 CD44 molecule (Indian blood group) Homo sapiens 20-24 27738333-0 2016 MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells. mir-139-5p 0-10 prominin 1 Homo sapiens 26-31 27738333-0 2016 MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells. mir-139-5p 0-10 notch receptor 1 Homo sapiens 83-89 27731509-12 2016 Overexpression of miR-139-5p decreased, whereas depletion of miR-139-5p enhanced the expression levels of NR2A, but not NR2B, induced by pilocarpine treatment. mir-139-5p 61-71 glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus 106-110 27731509-13 2016 Of interest, NMDA nonselective antagonist and NR2A selective antagonist enhanced miR-139-5p levels suppressed by pilocarpine treatment, whereas the NR2B selective antagonist was ineffective. mir-139-5p 81-91 glutamate ionotropic receptor NMDA type subunit 2A Rattus norvegicus 46-50 27633066-8 2016 Ectopic expression of miR-139-5p has not repressed the expression of KPNA4, but inhibited the nuclear import of NF-kappaB and phosphorylation of Akt. mir-139-5p 22-32 AKT serine/threonine kinase 1 Homo sapiens 145-148 27383270-0 2016 Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation. mir-139-5p 64-74 phosphodiesterase 4D Homo sapiens 40-60 27383270-0 2016 Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation. mir-139-5p 64-74 tumor protein p53 Homo sapiens 90-93 27383270-2 2016 Here, we report miR-139-5p as another new p53 microRNA target. mir-139-5p 16-26 tumor protein p53 Homo sapiens 42-45 27383270-7 2016 Finally, overexpression of miR-139-5p suppressed the growth of xenograft tumors, accompanied by decrease in PDE4D and increase in BIM. mir-139-5p 27-37 phosphodiesterase 4D Homo sapiens 108-113 27383270-7 2016 Finally, overexpression of miR-139-5p suppressed the growth of xenograft tumors, accompanied by decrease in PDE4D and increase in BIM. mir-139-5p 27-37 BCL2 like 11 Homo sapiens 130-133 27173050-0 2016 miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. mir-139-5p 0-10 notch receptor 1 Homo sapiens 77-84 27668889-13 2016 In vitro, the level of TNF-alpha was significantly elevated in supernatant of cells with upregulation of miR-139-5p. mir-139-5p 105-115 tumor necrosis factor Homo sapiens 23-32 27668889-15 2016 Thus, we have demonstrated a novel inflammation-regulatory mechanism involving TNF-alpha and c-FOS transcription through miR-139-5p in the NF-kappaB signaling pathway. mir-139-5p 121-131 tumor necrosis factor Homo sapiens 79-88 27668889-15 2016 Thus, we have demonstrated a novel inflammation-regulatory mechanism involving TNF-alpha and c-FOS transcription through miR-139-5p in the NF-kappaB signaling pathway. mir-139-5p 121-131 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 93-98 27173050-6 2016 In addition, miR-139-5p inhibited the expression of the miR-139-5p target gene NOTCH-1 and its downstream molecules MRP-1 and BCL-2, two key MDR-associated genes. mir-139-5p 13-23 notch receptor 1 Homo sapiens 79-86 27173050-6 2016 In addition, miR-139-5p inhibited the expression of the miR-139-5p target gene NOTCH-1 and its downstream molecules MRP-1 and BCL-2, two key MDR-associated genes. mir-139-5p 13-23 ATP binding cassette subfamily C member 1 Homo sapiens 116-121 27173050-6 2016 In addition, miR-139-5p inhibited the expression of the miR-139-5p target gene NOTCH-1 and its downstream molecules MRP-1 and BCL-2, two key MDR-associated genes. mir-139-5p 13-23 BCL2 apoptosis regulator Homo sapiens 126-131 27022656-0 2015 The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. mir-139-5p 12-22 thymoma viral proto-oncogene 1 Mus musculus 83-86 26859226-0 2016 Targeted deletion of miR-139-5p activates MAPK, NF-kappaB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. mir-139-5p 21-31 signal transducer and activator of transcription 3 Mus musculus 62-67 27022656-7 2015 Furthermore, biochemical studies in HCT-116 cells revealed that the over-expression of miR-139-5p inhibited the crosstalk between PI3K/AKT and Wnt pathway mediated by IGF-1R. mir-139-5p 87-97 AKT serine/threonine kinase 1 Homo sapiens 135-138 27022656-7 2015 Furthermore, biochemical studies in HCT-116 cells revealed that the over-expression of miR-139-5p inhibited the crosstalk between PI3K/AKT and Wnt pathway mediated by IGF-1R. mir-139-5p 87-97 insulin like growth factor 1 receptor Homo sapiens 167-173 26299922-0 2015 MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel. mir-139-5p 0-10 notch receptor 1 Homo sapiens 80-86 26497851-6 2015 In addition, miR-139-5p induced apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene Bcl2. mir-139-5p 13-23 BCL2 apoptosis regulator Homo sapiens 157-161 26497851-7 2015 Moreover, miR-139-5p inhibited cellular metastasis through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. mir-139-5p 10-20 matrix metallopeptidase 7 Homo sapiens 73-106 26497851-7 2015 Moreover, miR-139-5p inhibited cellular metastasis through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. mir-139-5p 10-20 matrix metallopeptidase 9 Homo sapiens 111-116 26097570-10 2015 CONCLUSIONS: Our results indicated that miR-139-5p acts as a tumor suppressor in NSCLC partially via down-regulating IGF1R expression. mir-139-5p 40-50 insulin like growth factor 1 receptor Homo sapiens 117-122 25833697-0 2015 miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM. mir-139-5p 0-10 zinc finger E-box binding homeobox 1 Homo sapiens 75-79 25833697-0 2015 miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM. mir-139-5p 0-10 zinc finger E-box binding homeobox 2 Homo sapiens 84-88 25833697-4 2015 Bioinformatics coupled with luciferase and Western blot assays also revealed that miR-139-5p inhibited expression of ZEB1 and ZEB2, which are master regulators of tumor metastasis. mir-139-5p 82-92 zinc finger E-box binding homeobox 1 Homo sapiens 117-121 25833697-4 2015 Bioinformatics coupled with luciferase and Western blot assays also revealed that miR-139-5p inhibited expression of ZEB1 and ZEB2, which are master regulators of tumor metastasis. mir-139-5p 82-92 zinc finger E-box binding homeobox 2 Homo sapiens 126-130 25536154-3 2015 Here, miR-139-5p was identified as an inhibitor of 3T3-L1 adipocyte differentiation with significantly down-regulating the expression levels of adipogenic marker genes PPAR gamma (P < 0.01), aP2 (P < 0.01) and FAS (P < 0.01). mir-139-5p 6-16 peroxisome proliferator activated receptor gamma Mus musculus 168-178 25536154-3 2015 Here, miR-139-5p was identified as an inhibitor of 3T3-L1 adipocyte differentiation with significantly down-regulating the expression levels of adipogenic marker genes PPAR gamma (P < 0.01), aP2 (P < 0.01) and FAS (P < 0.01). mir-139-5p 6-16 transcription factor AP-2, alpha Mus musculus 194-197 25536154-6 2015 In addition, the overexpression of Notch1 or IRS1 partially restored the suppressive effects miR-139-5p on differentiation of 3T3-L1 cells. mir-139-5p 93-103 notch 1 Mus musculus 35-41 25536154-6 2015 In addition, the overexpression of Notch1 or IRS1 partially restored the suppressive effects miR-139-5p on differentiation of 3T3-L1 cells. mir-139-5p 93-103 insulin receptor substrate 1 Mus musculus 45-49 25536154-7 2015 To our knowledge, this was the first report that miR-139-5p functioned negatively by targeting Notch1 and IRS1 during 3T3-L1 adipogenesis, regulating the transition from clonal expansion to terminal differentiation. mir-139-5p 49-59 notch 1 Mus musculus 95-101 25536154-7 2015 To our knowledge, this was the first report that miR-139-5p functioned negatively by targeting Notch1 and IRS1 during 3T3-L1 adipogenesis, regulating the transition from clonal expansion to terminal differentiation. mir-139-5p 49-59 insulin receptor substrate 1 Mus musculus 106-110 24647639-0 2014 miR-139-5p modulates cortical neuronal migration by targeting Lis1 in a rat model of focal cortical dysplasia. mir-139-5p 0-10 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Rattus norvegicus 62-66 25529604-8 2015 Taken together, these results suggest that miR-139-5p is an important negative regulator in myogenesis through blocking the Wnt1-mediated Wnt/beta-catenin signaling pathway. mir-139-5p 43-53 wingless-type MMTV integration site family, member 1 Mus musculus 124-128 25529604-8 2015 Taken together, these results suggest that miR-139-5p is an important negative regulator in myogenesis through blocking the Wnt1-mediated Wnt/beta-catenin signaling pathway. mir-139-5p 43-53 catenin (cadherin associated protein), beta 1 Mus musculus 142-154 25149074-0 2014 MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. mir-139-5p 0-10 autocrine motility factor receptor Homo sapiens 82-86 25149074-0 2014 MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. mir-139-5p 0-10 notch receptor 1 Homo sapiens 91-97 25149074-5 2014 Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1. mir-139-5p 41-51 autocrine motility factor receptor Homo sapiens 107-111 25149074-5 2014 Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1. mir-139-5p 41-51 notch receptor 1 Homo sapiens 116-122 24647639-10 2014 Moreover, the injured cortex showed a certain degree of recovery following the administration of miR-139-5p, demonstrating that the reduction in miR-139-5p was at least partially responsible for the upregulation of Lis1 in the rat brains. mir-139-5p 97-107 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Rattus norvegicus 215-219 24647639-10 2014 Moreover, the injured cortex showed a certain degree of recovery following the administration of miR-139-5p, demonstrating that the reduction in miR-139-5p was at least partially responsible for the upregulation of Lis1 in the rat brains. mir-139-5p 145-155 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Rattus norvegicus 215-219 24647639-11 2014 Our data suggest that miR-139-5p modulates cortical neuronal migration by targeting Lis1. mir-139-5p 22-32 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 Rattus norvegicus 84-88 24885920-7 2014 miR-139-5p induced apoptosis (P < 0.01), concomitantly with up-regulation of key apoptosis genes including cleaved caspase-8, caspase-3, caspase-7 and PARP. mir-139-5p 0-10 caspase 8 Mus musculus 118-127 24885920-7 2014 miR-139-5p induced apoptosis (P < 0.01), concomitantly with up-regulation of key apoptosis genes including cleaved caspase-8, caspase-3, caspase-7 and PARP. mir-139-5p 0-10 caspase 3 Mus musculus 129-138 24885920-7 2014 miR-139-5p induced apoptosis (P < 0.01), concomitantly with up-regulation of key apoptosis genes including cleaved caspase-8, caspase-3, caspase-7 and PARP. mir-139-5p 0-10 caspase 7 Mus musculus 140-149 24885920-7 2014 miR-139-5p induced apoptosis (P < 0.01), concomitantly with up-regulation of key apoptosis genes including cleaved caspase-8, caspase-3, caspase-7 and PARP. mir-139-5p 0-10 poly (ADP-ribose) polymerase family, member 1 Mus musculus 154-158 24885920-8 2014 miR-139-5p also caused cell cycle arrest in G0/G1 phase (P < 0.01), with upregulation of key G0/G1 phase regulators p21Cip1/Waf1 and p27Kip1. mir-139-5p 0-10 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 119-126 24885920-8 2014 miR-139-5p also caused cell cycle arrest in G0/G1 phase (P < 0.01), with upregulation of key G0/G1 phase regulators p21Cip1/Waf1 and p27Kip1. mir-139-5p 0-10 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 127-131 24885920-8 2014 miR-139-5p also caused cell cycle arrest in G0/G1 phase (P < 0.01), with upregulation of key G0/G1 phase regulators p21Cip1/Waf1 and p27Kip1. mir-139-5p 0-10 cyclin-dependent kinase inhibitor 1B Mus musculus 136-143 24885920-9 2014 Moreover, miR-139-5p inhibited cellular migration (P < 0.001) and invasiveness (P < 0.001) through the inhibition of matrix metalloproteinases (MMP)7 and MMP9. mir-139-5p 10-20 matrix metallopeptidase 7 Mus musculus 123-155 24885920-9 2014 Moreover, miR-139-5p inhibited cellular migration (P < 0.001) and invasiveness (P < 0.001) through the inhibition of matrix metalloproteinases (MMP)7 and MMP9. mir-139-5p 10-20 matrix metallopeptidase 9 Mus musculus 160-164 34790800-0 2021 MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway. mir-139-5p 0-10 phosphodiesterase 4D, cAMP specific Mus musculus 58-78 33822016-5 2021 Our findings revealed that miR-139-5p decreased IL-1beta and TNF-alpha levels to inhibit Salmonella-induced inflammatory responses in the RAW264.7 macrophage cell line. mir-139-5p 27-37 interleukin 1 alpha Mus musculus 48-56 33822016-5 2021 Our findings revealed that miR-139-5p decreased IL-1beta and TNF-alpha levels to inhibit Salmonella-induced inflammatory responses in the RAW264.7 macrophage cell line. mir-139-5p 27-37 tumor necrosis factor Mus musculus 61-70 33822016-6 2021 Furthermore, miR-139-5p inhibited Salmonella-induced oxidative stress by strengthening SOD, CAT, and GSH-PX activity, as well as lowering the malondialdehyde level in the RAW264.7 macrophages cell line. mir-139-5p 13-23 catalase Mus musculus 92-95 33822016-8 2021 Rescue assays indicated that the over-expression of miR-139-5p inhibits the effects of TRAF6 on inflammatory and oxidative stress responses including Salmonella infection in RAW264.7 cells. mir-139-5p 52-62 TNF receptor-associated factor 6 Mus musculus 87-92 33822016-9 2021 To our knowledge, this study is the first to verify that miR-139-5p inhibits inflammatory and oxidative stress responses of Salmonella-infected macrophages through regulating TRAF6. mir-139-5p 57-67 TNF receptor-associated factor 6 Mus musculus 175-180 34808393-13 2022 Finally, miR-139-5p inhibition mitigated the inhibitory effect of sh-NEAT1 on lipid accumulation. mir-139-5p 9-19 nuclear paraspeckle assembly transcript 1 Homo sapiens 69-74 34808393-14 2022 CONCLUSION: NEAT1 aggravated FFA-induced lipid accumulation in hepatocytes by regulating the c-Jun/SREBP1c axis by sponging miR-139-5p, indicating the potential of NEAT1 as a promising therapeutic target for NAFLD. mir-139-5p 124-134 nuclear paraspeckle assembly transcript 1 Homo sapiens 12-17 34808393-14 2022 CONCLUSION: NEAT1 aggravated FFA-induced lipid accumulation in hepatocytes by regulating the c-Jun/SREBP1c axis by sponging miR-139-5p, indicating the potential of NEAT1 as a promising therapeutic target for NAFLD. mir-139-5p 124-134 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 93-98 34808393-14 2022 CONCLUSION: NEAT1 aggravated FFA-induced lipid accumulation in hepatocytes by regulating the c-Jun/SREBP1c axis by sponging miR-139-5p, indicating the potential of NEAT1 as a promising therapeutic target for NAFLD. mir-139-5p 124-134 sterol regulatory element binding transcription factor 1 Homo sapiens 99-106 34808393-14 2022 CONCLUSION: NEAT1 aggravated FFA-induced lipid accumulation in hepatocytes by regulating the c-Jun/SREBP1c axis by sponging miR-139-5p, indicating the potential of NEAT1 as a promising therapeutic target for NAFLD. mir-139-5p 124-134 nuclear paraspeckle assembly transcript 1 Homo sapiens 164-169 34539847-14 2021 miR-139-5p inhibitor-induced upregulated BBC3 expression was reversed following transfection with BBC3-siRNA. mir-139-5p 0-10 BCL2 binding component 3 Homo sapiens 41-45 34539847-14 2021 miR-139-5p inhibitor-induced upregulated BBC3 expression was reversed following transfection with BBC3-siRNA. mir-139-5p 0-10 BCL2 binding component 3 Homo sapiens 98-102 34539847-17 2021 In conclusion, the results of the present study suggested that miR-139-5p may play a key role in the progression of endometriosis by regulating the viability of ESCs and directly targeting BBC3. mir-139-5p 63-73 BCL2 binding component 3 Homo sapiens 189-193 34745206-7 2021 In conclusion, these results suggest that miR-139-5p plays an important role in osteogenic differentiation of VICs via the Wnt/beta-Catenin pathway, which may further provide a new therapeutic target for CAVD. mir-139-5p 42-52 catenin beta 1 Homo sapiens 127-139 34899908-11 2021 CircRNF13 could serve as the molecular sponge of miR-139-5p to inhibit its association with IGF1R that eventually accelerated the malignant progression of PC. mir-139-5p 49-59 insulin like growth factor 1 receptor Homo sapiens 92-97 34899908-12 2021 Conclusion: CircRNF13 serves as a competitive endogenous RNA of IGF1R to inhibit the function of miR-139-5p that eventually reinforces the malignant phenotype of PC. mir-139-5p 97-107 insulin like growth factor 1 receptor Homo sapiens 64-69 34853466-9 2022 Rescue assays suggested that miR-139-5p affected GTF2E2-mediated ESCC progression. mir-139-5p 29-39 general transcription factor IIE subunit 2 Homo sapiens 49-55 34790800-0 2021 MiR-139-5p has an antidepressant-like effect by targeting phosphodiesterase 4D to activate the cAMP/PKA/CREB signaling pathway. mir-139-5p 0-10 cAMP responsive element binding protein 1 Mus musculus 104-108 34790800-13 2021 Conclusions: Our findings suggested that miR-139-5p acted like an antidepressant by targeting PDE4D, thereby regulating the cAMP/protein kinase A (PKA)/CREB/BDNF pathway to improve depression. mir-139-5p 41-51 phosphodiesterase 4D, cAMP specific Mus musculus 94-99 34790800-13 2021 Conclusions: Our findings suggested that miR-139-5p acted like an antidepressant by targeting PDE4D, thereby regulating the cAMP/protein kinase A (PKA)/CREB/BDNF pathway to improve depression. mir-139-5p 41-51 cAMP responsive element binding protein 1 Mus musculus 152-156 34790800-13 2021 Conclusions: Our findings suggested that miR-139-5p acted like an antidepressant by targeting PDE4D, thereby regulating the cAMP/protein kinase A (PKA)/CREB/BDNF pathway to improve depression. mir-139-5p 41-51 brain derived neurotrophic factor Mus musculus 157-161 34434273-8 2021 A dual-luciferase reporter assay was used to confirm the direct targeting of ROCK1 by miR-139-5p. mir-139-5p 86-96 Rho-associated coiled-coil containing protein kinase 1 Mus musculus 77-82 34434273-15 2021 Overexpression of ROCK1 in NHBEs restored the ROS levels and proinflammatory cytokine production inhibited by miR-139-5p. mir-139-5p 110-120 Rho-associated coiled-coil containing protein kinase 1 Mus musculus 18-23 34434273-16 2021 In conclusion, miR-139-5p alleviated sepsis-induced ALI via suppression of its downstream target, ROCK1, suggesting that miR-139-5p may hold promise in the treatment of sepsis-induced ALI. mir-139-5p 15-25 Rho-associated coiled-coil containing protein kinase 1 Mus musculus 98-103 34434273-16 2021 In conclusion, miR-139-5p alleviated sepsis-induced ALI via suppression of its downstream target, ROCK1, suggesting that miR-139-5p may hold promise in the treatment of sepsis-induced ALI. mir-139-5p 121-131 Rho-associated coiled-coil containing protein kinase 1 Mus musculus 98-103 34531378-5 2021 The co-localization of lncRNA NEAT1 with miR-139-5p was shown in the cytosols of activated HSCs. mir-139-5p 41-51 nuclear paraspeckle assembly transcript 1 (non-protein coding) Mus musculus 30-35 34725544-10 2021 The results demonstrated that overexpression of miR-139-5p effectively repressed HG-activated inflammation, as indicated by the upregulation of inflammation cytokines, including TNF-alpha, IL-6, and Cox-2, in ARPE-19 cells. mir-139-5p 48-58 tumor necrosis factor Homo sapiens 178-187 34725544-10 2021 The results demonstrated that overexpression of miR-139-5p effectively repressed HG-activated inflammation, as indicated by the upregulation of inflammation cytokines, including TNF-alpha, IL-6, and Cox-2, in ARPE-19 cells. mir-139-5p 48-58 interleukin 6 Homo sapiens 189-193 34725544-10 2021 The results demonstrated that overexpression of miR-139-5p effectively repressed HG-activated inflammation, as indicated by the upregulation of inflammation cytokines, including TNF-alpha, IL-6, and Cox-2, in ARPE-19 cells. mir-139-5p 48-58 mitochondrially encoded cytochrome c oxidase II Homo sapiens 199-204 34725544-13 2021 Mechanistically, knockdown of LMO4 reversed the biological role of miR-139-5p in proliferation, apoptosis, oxidative stress, and release of inflammation factors in vitro. mir-139-5p 67-77 LIM domain only 4 Homo sapiens 30-34 34725544-14 2021 Collectively, these results suggested that miR-139-5p significantly decreased ARPE-19 cell injury caused by HG by inducing proliferation and suppressing cell apoptosis, oxidant stress, and inflammation by modulating LMO4. mir-139-5p 43-53 LIM domain only 4 Homo sapiens 216-220 34531378-6 2021 miR-139-5p upregulation could suppress the expression of beta-catenin. mir-139-5p 0-10 catenin (cadherin associated protein), beta 1 Mus musculus 57-69 34522182-11 2021 A negative correlation between CCT5 and miR-139-5p was found in TCGA dataset. mir-139-5p 40-50 chaperonin containing TCP1 subunit 5 Homo sapiens 31-35 34144190-3 2021 METHODS: A dual-luciferase reporter assay was utilized to confirm the interaction of miR-139-5p with vascular endothelial growth factor receptor-1 (VEGFR-1). mir-139-5p 85-95 fms related receptor tyrosine kinase 1 Homo sapiens 101-146 34144190-3 2021 METHODS: A dual-luciferase reporter assay was utilized to confirm the interaction of miR-139-5p with vascular endothelial growth factor receptor-1 (VEGFR-1). mir-139-5p 85-95 fms related receptor tyrosine kinase 1 Homo sapiens 148-155 34144190-8 2021 RESULTS: miR-139-5p suppressed cell viability by directly targeting VEGFR-1 in HUVECs. mir-139-5p 9-19 fms related receptor tyrosine kinase 1 Homo sapiens 68-75 34144190-11 2021 miR-139-5p inhibited cell viability by inhibiting VEGFR-1 in hypoxia-treated HUVECs. mir-139-5p 0-10 fms related receptor tyrosine kinase 1 Homo sapiens 50-57 34144190-12 2021 CONCLUSION: miR-139-5p inhibits endothelial cell viability of AMI by inhibiting VEGFR-1, and increased miR-139-5p expression in AMI patients has high diagnostic value for AMI screening, indicating that miR-139-5p may serve as a diagnostic biomarker and molecular therapeutic target for AMI. mir-139-5p 12-22 fms related receptor tyrosine kinase 1 Homo sapiens 80-87 34144190-12 2021 CONCLUSION: miR-139-5p inhibits endothelial cell viability of AMI by inhibiting VEGFR-1, and increased miR-139-5p expression in AMI patients has high diagnostic value for AMI screening, indicating that miR-139-5p may serve as a diagnostic biomarker and molecular therapeutic target for AMI. mir-139-5p 202-212 fms related receptor tyrosine kinase 1 Homo sapiens 80-87 34522182-15 2021 Conclusions: MiR-139-5p suppresses HCC tumor aggression and conversely correlated with CCT5. mir-139-5p 13-23 chaperonin containing TCP1 subunit 5 Homo sapiens 87-91 34368980-8 2022 The relationship between miR-139-5p and circTHBS1 or MFN2 was confirmed using the dual-luciferase reporter assay and RIP assay. mir-139-5p 25-35 mitofusin 2 Homo sapiens 53-57 34368980-12 2022 In addition, miR-139-5p could target MFN2, and it could inhibit the progression of IC cells by targeting MFN2. mir-139-5p 13-23 mitofusin 2 Homo sapiens 37-41 34368980-12 2022 In addition, miR-139-5p could target MFN2, and it could inhibit the progression of IC cells by targeting MFN2. mir-139-5p 13-23 mitofusin 2 Homo sapiens 105-109 35254597-0 2022 MiR-139-5p/ENAH Affects Progression of Hepatocellular Carcinoma Cells. mir-139-5p 0-10 ENAH actin regulator Homo sapiens 11-15 34349521-0 2021 LINC00152 Promotes the Growth and Invasion of Oral Squamous Cell Carcinoma by Regulating miR-139-5p (Retraction). mir-139-5p 89-99 cytoskeleton regulator RNA Homo sapiens 0-9 34094932-0 2021 HOXA13, Negatively Regulated by miR-139-5p, Decreases the Sensitivity of Gastric Cancer to 5-Fluorouracil Possibly by Targeting ABCC4. mir-139-5p 32-42 homeobox A13 Homo sapiens 0-6 34094932-0 2021 HOXA13, Negatively Regulated by miR-139-5p, Decreases the Sensitivity of Gastric Cancer to 5-Fluorouracil Possibly by Targeting ABCC4. mir-139-5p 32-42 ATP binding cassette subfamily C member 4 Homo sapiens 128-133 34094932-9 2021 Luciferase reporter assay was performed to assess interaction of miR-139-5p and HOXA13. mir-139-5p 65-75 homeobox A13 Homo sapiens 80-86 34094932-12 2021 Mechanistically, HOXA13, directly targeted by miR-139-5p in GC, might upregulate ABCC4 expression, thereby accentuating 5-FU resistance of GC cells. mir-139-5p 46-56 homeobox A13 Homo sapiens 17-23 34094932-12 2021 Mechanistically, HOXA13, directly targeted by miR-139-5p in GC, might upregulate ABCC4 expression, thereby accentuating 5-FU resistance of GC cells. mir-139-5p 46-56 ATP binding cassette subfamily C member 4 Homo sapiens 81-86 35414313-10 2022 Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR-139-5p in endometriosis. mir-139-5p 141-151 dehydrogenase/reductase 4 Homo sapiens 37-42 35414313-10 2022 Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR-139-5p in endometriosis. mir-139-5p 141-151 prostaglandin D2 receptor Homo sapiens 43-46 35124564-6 2022 More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models. mir-139-5p 33-43 forkhead box O1 Mus musculus 55-60 35124564-6 2022 More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models. mir-139-5p 33-43 kelch-like ECH-associated protein 1 Mus musculus 77-82 35124564-6 2022 More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models. mir-139-5p 33-43 thioredoxin interacting protein Mus musculus 198-203 35124564-6 2022 More importantly, Rd upregulated miR-139-5p to inhibit FoxO1 which regulates Keap1 transcriptional activity, and subsequently activates the Nrf2 antioxidant pathway, resulting in attenuation of ROS/TXNIP/NLRP3 inflammasome axis-driven pyroptosis in these animal and cell models. mir-139-5p 33-43 NLR family, pyrin domain containing 3 Mus musculus 204-209 35350177-7 2022 Flow cytometry assays showed that HA increased CD31 positive cells proportion in MSC-ECFC and could be reversed by miR-139-5p mimics transfection. mir-139-5p 115-125 platelet and endothelial cell adhesion molecule 1 Homo sapiens 47-51 34142698-0 2021 miR-139-5p mediates the palmitate-induced inhibition of insulin secretion by targeting neuronal pentraxin 1 in INS-1 cells. mir-139-5p 0-10 neuronal pentraxin 1 Rattus norvegicus 87-107 34142698-5 2021 The regulation of NPTX1 by miR-139-5p was examined by luciferase assay. mir-139-5p 27-37 neuronal pentraxin 1 Rattus norvegicus 18-23 34142698-12 2021 Furthermore, we demonstrated that NPTX1 is a target of miR-139-5p. mir-139-5p 55-65 neuronal pentraxin 1 Rattus norvegicus 34-39 34142698-13 2021 miR-139-5p mediated palmitate-induced insulin secretion defects by targeting NPTX1. mir-139-5p 0-10 neuronal pentraxin 1 Rattus norvegicus 77-82 34142698-16 2021 Collectively, our results illustrate that the induction of beta-cell insulin secretion defects by fatty acids is mediated, at least in part, by miR-139-5p via downregulation of NPTX1 expression. mir-139-5p 144-154 neuronal pentraxin 1 Mus musculus 177-182 35543383-7 2022 Moreover, as a potential target for miR-139-5p, NR3C1 level was reduced by miR-139-5p mimic. mir-139-5p 36-46 nuclear receptor subfamily 3 group C member 1 Homo sapiens 48-53 35543383-7 2022 Moreover, as a potential target for miR-139-5p, NR3C1 level was reduced by miR-139-5p mimic. mir-139-5p 75-85 nuclear receptor subfamily 3 group C member 1 Homo sapiens 48-53 35543383-8 2022 Altogether, by activating the BDNF-TrkB signaling pathway, miR-139-5p inhibition plays an antidepressant-like role and might serve as an effective depression target (Fig. mir-139-5p 59-69 brain derived neurotrophic factor Homo sapiens 30-34 35543383-8 2022 Altogether, by activating the BDNF-TrkB signaling pathway, miR-139-5p inhibition plays an antidepressant-like role and might serve as an effective depression target (Fig. mir-139-5p 59-69 neurotrophic receptor tyrosine kinase 2 Homo sapiens 35-39 35396925-9 2022 Mechanistically, circDNER sponged miR-139-5p to upregulate ITGB8 expression. mir-139-5p 34-44 integrin subunit beta 8 Homo sapiens 59-64 35438846-13 2022 The miR-139-5p inhibited cell proliferation by negatively regulating NME1 expression. mir-139-5p 4-14 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 69-73 35438846-15 2022 The NME1 is negatively regulated by miR-139-5p to inhibit cell proliferation. mir-139-5p 36-46 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 4-8 35469231-7 2022 Furthermore, a rescue experiment confirmed miR-139-5p affected the proliferation and angiogenesis of HBMEC through FGB. mir-139-5p 43-53 fibrinogen beta chain Homo sapiens 115-118 35254597-10 2022 Additionally, ENAH could reverse the suppressive impacts of miR-139-5p on HCC cell behaviors. mir-139-5p 60-70 ENAH actin regulator Mus musculus 14-18 35254597-12 2022 MiR-139-5p hampered HCC cell processes by mediating ENAH, and miR-139-5p/ENAH is hopefully to be the possible target for HCC patients. mir-139-5p 0-10 ENAH actin regulator Homo sapiens 52-56 35254597-12 2022 MiR-139-5p hampered HCC cell processes by mediating ENAH, and miR-139-5p/ENAH is hopefully to be the possible target for HCC patients. mir-139-5p 62-72 ENAH actin regulator Homo sapiens 73-77 35181869-0 2022 MiR-139-5p Targeting CCNB1 Modulates Proliferation, Migration, Invasion and Cell Cycle in Lung Adenocarcinoma. mir-139-5p 0-10 cyclin B1 Homo sapiens 21-26 35181869-15 2022 MiR-139-5p expressed an evidently negative correlation with CCNB1 and was predicted to target CCNB1. mir-139-5p 0-10 cyclin B1 Homo sapiens 60-65 35181869-15 2022 MiR-139-5p expressed an evidently negative correlation with CCNB1 and was predicted to target CCNB1. mir-139-5p 0-10 cyclin B1 Homo sapiens 94-99 35181869-16 2022 MiR-139-5p mimics reduced CCNB1 mRNA and protein expression, and suppressed luciferase activity in a target-specific manner, as confirmed by a control construct with a mutated miR-139-5p binding site. mir-139-5p 0-10 cyclin B1 Homo sapiens 26-31 35181869-18 2022 Mechanistically, miR-139-5p might negatively regulate CCNB1 in LUAD, thereby suppressing cell proliferation, migration, invasion and cell cycle. mir-139-5p 17-27 cyclin B1 Homo sapiens 54-59 35222884-0 2022 MiR-139-5p Inhibits the Development of Gastric Cancer through Targeting TPD52. mir-139-5p 0-10 tumor protein D52 Homo sapiens 72-77 35222884-8 2022 Furthermore, miR-139-5p directly targeted TPD52. mir-139-5p 13-23 tumor protein D52 Homo sapiens 42-47 35222884-10 2022 And TPD52 upregulation weakened the antitumor effect of miR-139-5p in GC. mir-139-5p 56-66 tumor protein D52 Homo sapiens 4-9 35222884-11 2022 Conclusion: MiR-139-5p inhibits GC cell proliferation and metastasis through downregulating TPD52. mir-139-5p 12-22 tumor protein D52 Homo sapiens 92-97