PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33970415-15	2021	In conclusion, ursolic acid can inhibit the proliferation and migration of VSMCs in aortic aneurysm mice through the miR-126/PTEN/PI3K/AKT/mTOR signaling pathway.	ursolic acid	15-27	mechanistic target of rapamycin kinase	Mus musculus	139-143
33970415-9	2021	Compared with the model group, the expression of miR-126 and PTEN mRNA in the ursolic acid group was significantly reduced and increased, respectively.	ursolic acid	78-90	microRNA 126a	Mus musculus	49-56
33964283-4	2021	In this study, we discovered two derivatives of ursolic acid, 3beta-hydroxyurs-12,18-dien-28-oic acid (randialic acid B, RAB) and 3beta-hydroxyurs-12,19-dien-28-oic acid (tomentosolic acid, TA), as FPR1 inhibitors in human neutrophils with ability to suppress psoriatic symptoms in mice.	ursolic acid	48-60	ArfGAP with FG repeats 1	Homo sapiens	121-124
33970415-9	2021	Compared with the model group, the expression of miR-126 and PTEN mRNA in the ursolic acid group was significantly reduced and increased, respectively.	ursolic acid	78-90	phosphatase and tensin homolog	Mus musculus	61-65
33970415-13	2021	Compared with the model group, the expression of PI3K, AKT, and mTOR protein in the ursolic acid group was significantly reduced.	ursolic acid	84-96	thymoma viral proto-oncogene 1	Mus musculus	55-58
33970415-13	2021	Compared with the model group, the expression of PI3K, AKT, and mTOR protein in the ursolic acid group was significantly reduced.	ursolic acid	84-96	mechanistic target of rapamycin kinase	Mus musculus	64-68
33970415-15	2021	In conclusion, ursolic acid can inhibit the proliferation and migration of VSMCs in aortic aneurysm mice through the miR-126/PTEN/PI3K/AKT/mTOR signaling pathway.	ursolic acid	15-27	microRNA 126a	Mus musculus	117-124
33970415-15	2021	In conclusion, ursolic acid can inhibit the proliferation and migration of VSMCs in aortic aneurysm mice through the miR-126/PTEN/PI3K/AKT/mTOR signaling pathway.	ursolic acid	15-27	phosphatase and tensin homolog	Mus musculus	125-129
33970415-15	2021	In conclusion, ursolic acid can inhibit the proliferation and migration of VSMCs in aortic aneurysm mice through the miR-126/PTEN/PI3K/AKT/mTOR signaling pathway.	ursolic acid	15-27	thymoma viral proto-oncogene 1	Mus musculus	135-138
33964283-4	2021	In this study, we discovered two derivatives of ursolic acid, 3beta-hydroxyurs-12,18-dien-28-oic acid (randialic acid B, RAB) and 3beta-hydroxyurs-12,19-dien-28-oic acid (tomentosolic acid, TA), as FPR1 inhibitors in human neutrophils with ability to suppress psoriatic symptoms in mice.	ursolic acid	48-60	formyl peptide receptor 1	Homo sapiens	198-202
33452572-0	2021	Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1beta through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	62-70
34007853-8	2021	UA alleviated UC inflammation and lowered serum and colon IL-6 levels.	ursolic acid	0-2	interleukin 6	Mus musculus	58-62
34007853-9	2021	Three classical inflammatory pathways: MAPKs, IL-6/STAT3, and PI3K were downregulated by UA treatment.	ursolic acid	89-91	interleukin 6	Mus musculus	46-50
34007853-9	2021	Three classical inflammatory pathways: MAPKs, IL-6/STAT3, and PI3K were downregulated by UA treatment.	ursolic acid	89-91	signal transducer and activator of transcription 3	Mus musculus	51-56
33842675-6	2021	All the phytochemicals follow Lipinski"s rule of five and molecular docking result shows best binding affinity of Podofilox - 7.54 kcal/mol with ACE2, Psoralidin - 8.04 kcal/mol with Furin, Ursolic acid - 8.88 kcal/mol with 3CLpro and Epiafzelechin - 8.26 kcal/mol with RdRp.	ursolic acid	190-202	furin, paired basic amino acid cleaving enzyme	Homo sapiens	183-188
33842675-8	2021	Also blocking viral proteins 3CLpro and RdRp with Ursolic acid and Epiafzelechin may prevent viral replication or transcription.	ursolic acid	50-62	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	40-44
33452572-0	2021	Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1beta through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	0-12	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	88-94
33452572-0	2021	Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1beta through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	0-12	microRNA 206	Homo sapiens	95-102
33452572-0	2021	Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1beta through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	0-12	prostaglandin-endoperoxide synthase 1	Homo sapiens	103-108
33452572-0	2021	Ursolic acid ameliorates Nthy-ori 3-1 cells injury induced by IL-1beta through limiting MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	127-136
33452572-2	2021	OBJECTIVES: In the research, we assessed the effects of UA on Nthy-ori 3-1 cells stimulated by IL-1beta and attempted to elucidate the mechanisms underlying the effects.	ursolic acid	56-58	interleukin 1 alpha	Homo sapiens	95-103
33452572-13	2021	However, UA ameliorated the Nthy-ori 3-1 cells injury induced by IL-1beta through mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	9-11	interleukin 1 alpha	Homo sapiens	65-73
33452572-13	2021	However, UA ameliorated the Nthy-ori 3-1 cells injury induced by IL-1beta through mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	9-11	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	96-102
33452572-13	2021	However, UA ameliorated the Nthy-ori 3-1 cells injury induced by IL-1beta through mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	9-11	microRNA 206	Homo sapiens	103-110
33452572-13	2021	However, UA ameliorated the Nthy-ori 3-1 cells injury induced by IL-1beta through mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	9-11	prostaglandin-endoperoxide synthase 1	Homo sapiens	111-116
33452572-13	2021	However, UA ameliorated the Nthy-ori 3-1 cells injury induced by IL-1beta through mediating the MALAT1/miR-206/PTGS1 ceRNA network and NF-kappaB signaling pathway.	ursolic acid	9-11	nuclear factor kappa B subunit 1	Homo sapiens	135-144
33452572-14	2021	CONCLUSIONS: UA treatment significantly relieved the injury of Nthy-ori 3-1 cells via inhibiting the ceRNA mechanism of MALAT1/miR-206/PTGS1 and inflammatory pathways, insinuating that UA may be helpful for the treatment of AIT.	ursolic acid	13-15	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	120-126
33452572-14	2021	CONCLUSIONS: UA treatment significantly relieved the injury of Nthy-ori 3-1 cells via inhibiting the ceRNA mechanism of MALAT1/miR-206/PTGS1 and inflammatory pathways, insinuating that UA may be helpful for the treatment of AIT.	ursolic acid	13-15	microRNA 206	Homo sapiens	127-134
33452572-14	2021	CONCLUSIONS: UA treatment significantly relieved the injury of Nthy-ori 3-1 cells via inhibiting the ceRNA mechanism of MALAT1/miR-206/PTGS1 and inflammatory pathways, insinuating that UA may be helpful for the treatment of AIT.	ursolic acid	13-15	prostaglandin-endoperoxide synthase 1	Homo sapiens	135-140
33733926-3	2021	Additionally, GLUT4, AKT2 and AMPK were docked with catechin, epicatechin, kaempferol, metformin, quercetin and ursolic acid reportedly present in Potentilla fulgens.	ursolic acid	112-124	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	14-19
33394285-9	2021	Ursolic acid, but not fluoxetine, prevented CUS-induced increase in the expression of Bax, but both ursolic acid and fluoxetine prevented CUS-induced reduction on Bcl-2/Bax ratio.	ursolic acid	0-12	BCL2-associated X protein	Mus musculus	86-89
33682637-6	2021	It could be concluded that ursolic acid might be potential in inhibiting human pancreatic alpha-amylase, thus, potential to be developed as an anti-DMT2 drug candidate.	ursolic acid	27-39	amylase alpha 2A	Homo sapiens	79-103
33249187-8	2021	Further study showed that heat stress led to activation of PERK-eIF2alpha-CHOP signaling, which was attenuated by ursolic acid supplementation.	ursolic acid	114-126	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	59-63
33249187-8	2021	Further study showed that heat stress led to activation of PERK-eIF2alpha-CHOP signaling, which was attenuated by ursolic acid supplementation.	ursolic acid	114-126	eukaryotic translation initiation factor 2A	Mus musculus	64-73
33249187-8	2021	Further study showed that heat stress led to activation of PERK-eIF2alpha-CHOP signaling, which was attenuated by ursolic acid supplementation.	ursolic acid	114-126	DNA-damage inducible transcript 3	Mus musculus	74-78
33394285-9	2021	Ursolic acid, but not fluoxetine, prevented CUS-induced increase in the expression of Bax, but both ursolic acid and fluoxetine prevented CUS-induced reduction on Bcl-2/Bax ratio.	ursolic acid	100-112	B cell leukemia/lymphoma 2	Mus musculus	163-168
33394285-9	2021	Ursolic acid, but not fluoxetine, prevented CUS-induced increase in the expression of Bax, but both ursolic acid and fluoxetine prevented CUS-induced reduction on Bcl-2/Bax ratio.	ursolic acid	100-112	BCL2-associated X protein	Mus musculus	169-172
33394285-11	2021	Our study unveils the ability of ursolic acid to prevent the depressive-like behavior induced by stress and the modulation of Bcl-2/Bax expression could be associated with this response.	ursolic acid	33-45	BCL2-associated X protein	Mus musculus	132-135
33146673-7	2021	RESULTS: The network pharmacology research showed that TCM could decrease IL-6 using several compounds, such as quercetin, ursolic acid, luteolin, and rutin.	ursolic acid	123-135	interleukin 6	Homo sapiens	74-78
33009882-0	2021	Ursolic acid reduces Adriamycin resistance of human ovarian cancer cells through promoting the HuR translocation from cytoplasm to nucleus.	ursolic acid	0-12	ELAV like RNA binding protein 1	Homo sapiens	95-98
33009882-6	2021	Moreover, UA had no effects on HuR expression, but promoted the cytoplasm-nucleus translocation of HuR protein, decreased MDR1 mRNA stability and thus reduced MDR1 expression.	ursolic acid	10-12	ELAV like RNA binding protein 1	Homo sapiens	99-102
33009882-6	2021	Moreover, UA had no effects on HuR expression, but promoted the cytoplasm-nucleus translocation of HuR protein, decreased MDR1 mRNA stability and thus reduced MDR1 expression.	ursolic acid	10-12	ATP binding cassette subfamily B member 1	Homo sapiens	122-126
33009882-6	2021	Moreover, UA had no effects on HuR expression, but promoted the cytoplasm-nucleus translocation of HuR protein, decreased MDR1 mRNA stability and thus reduced MDR1 expression.	ursolic acid	10-12	ATP binding cassette subfamily B member 1	Homo sapiens	159-163
33549076-12	2021	UA arrested the cell cycle at the G0/G1 phase, and induced caspase-dependent apoptosis.	ursolic acid	0-2	caspase 8	Homo sapiens	59-66
33549076-13	2021	UA inhibited Bcl-2 expression and increased Bax expression.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	13-18
33549076-13	2021	UA inhibited Bcl-2 expression and increased Bax expression.	ursolic acid	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	44-47
33549076-15	2021	Furthermore, UA inhibited cell growth in a detached condition and induced anoikis in RKO cells that was accompanied by dampened phosphorylation of FAK, PI3K and AKT.	ursolic acid	13-15	protein tyrosine kinase 2	Homo sapiens	147-150
33549076-15	2021	Furthermore, UA inhibited cell growth in a detached condition and induced anoikis in RKO cells that was accompanied by dampened phosphorylation of FAK, PI3K and AKT.	ursolic acid	13-15	AKT serine/threonine kinase 1	Homo sapiens	161-164
33549076-17	2021	CONCLUSIONS: UA induced caspase-dependent apoptosis, and FAK/PI3K/AKT singling and EMT related anoikis in RKO cells.	ursolic acid	13-15	caspase 8	Homo sapiens	24-31
33368975-0	2021	Ursolic acid ameliorates hypobaric hypoxia-induced skeletal muscle protein loss via upregulating Akt pathway: An experimental study using rat model.	ursolic acid	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
33368975-10	2021	Furthermore, UA supplementation enhanced Akt, pAkt, and p70S6kinase activity (Akt pathway) and lowered the pro-inflammatory cytokines in HH exposed rats.	ursolic acid	13-15	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
33368975-10	2021	Furthermore, UA supplementation enhanced Akt, pAkt, and p70S6kinase activity (Akt pathway) and lowered the pro-inflammatory cytokines in HH exposed rats.	ursolic acid	13-15	AKT serine/threonine kinase 1	Rattus norvegicus	47-50
33368975-11	2021	UA has potent antioxidant and anti-inflammatory activity, and it enhanced the protein content via upregulation of Akt pathway-related proteins against HH exposure.	ursolic acid	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
33146673-11	2021	Quercetin, ursolic acid, luteolin, and rutin could inhibit COVID-19 by downregulating IL-6.	ursolic acid	11-23	interleukin 6	Homo sapiens	86-90
33493421-11	2021	Importantly, UA treatment impaired the malignant phenotypes of DOX-resistant MDA-MB-468 and MDA-MB-436 cells through ZEB1-AS1/ABCC1 axis.	ursolic acid	13-15	ATP binding cassette subfamily C member 1	Homo sapiens	126-131
33459176-9	2021	oleanolic acid, ursolic acid, 3beta-acetoxyolean-12-en-27-oic acid and isovitexin followed by the binding free energy calculations using MM-GBSA and these molecules have stable interactions with PLpro protein binding site.	ursolic acid	16-28	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	195-200
33493421-0	2021	Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis.	ursolic acid	0-12	zinc finger E-box binding homeobox 1	Homo sapiens	100-104
33493421-0	2021	Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis.	ursolic acid	0-12	prostaglandin D2 receptor	Homo sapiens	105-108
33493421-0	2021	Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis.	ursolic acid	0-12	microRNA 186	Homo sapiens	109-116
33493421-0	2021	Ursolic Acid Enhances Cytotoxicity of Doxorubicin-Resistant Triple-Negative Breast Cancer Cells via ZEB1-AS1/miR-186-5p/ABCC1 Axis.	ursolic acid	0-12	ATP binding cassette subfamily C member 1	Homo sapiens	120-125
33493421-8	2021	Mechanistically, multidrug resistance-associated protein 1 (ABCC1) expression was downregulated by UA treatment.	ursolic acid	99-101	ATP binding cassette subfamily C member 1	Homo sapiens	17-58
33493421-8	2021	Mechanistically, multidrug resistance-associated protein 1 (ABCC1) expression was downregulated by UA treatment.	ursolic acid	99-101	ATP binding cassette subfamily C member 1	Homo sapiens	60-65
33493421-11	2021	Importantly, UA treatment impaired the malignant phenotypes of DOX-resistant MDA-MB-468 and MDA-MB-436 cells through ZEB1-AS1/ABCC1 axis.	ursolic acid	13-15	zinc finger E-box binding homeobox 1	Homo sapiens	117-121
33493421-11	2021	Importantly, UA treatment impaired the malignant phenotypes of DOX-resistant MDA-MB-468 and MDA-MB-436 cells through ZEB1-AS1/ABCC1 axis.	ursolic acid	13-15	prostaglandin D2 receptor	Homo sapiens	122-125
33530486-0	2021	Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	61-64
33530486-4	2021	Inhibitor and fluorescent probe studies demonstrate that UA induces a caspase independent, JNK dependent, mechanism of cell death.	ursolic acid	57-59	mitogen-activated protein kinase 8	Homo sapiens	91-94
33628185-0	2020	Ursolic Acid Regulates Cell Cycle and Proliferation in Colon Adenocarcinoma by Suppressing Cyclin B1.	ursolic acid	0-12	cyclin B1	Homo sapiens	91-100
33452230-0	2021	Retracted: Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.	ursolic acid	11-23	mitogen-activated protein kinase 1	Homo sapiens	258-261
33532190-3	2021	Herein, a novel "core-shell" co-assembly carrier-free nanosystem was constructed based on natural sources of ursolic acid (UA) and polyphenol (EGCG) with the EpCAM-aptamer modification for hepatocellular carcinoma (HCC) synergistic treatment.	ursolic acid	123-125	epithelial cell adhesion molecule	Homo sapiens	158-163
33278391-0	2021	Inhibition of breast cancer stem-like cells by a triterpenoid, ursolic acid, via activation of Wnt antagonist, sFRP4 and suppression of miRNA-499a-5p.	ursolic acid	63-75	secreted frizzled related protein 4	Homo sapiens	111-116
33278391-4	2021	By using caspase 3/7, ROS, migration, TCF/LEF and CAM assays, overexpressing and inhibiting miR-499a-5p and NanoString PanCancer analysis, we observed that UA had significant anti-CSC ability.	ursolic acid	156-158	caspase 3	Homo sapiens	9-20
33278391-4	2021	By using caspase 3/7, ROS, migration, TCF/LEF and CAM assays, overexpressing and inhibiting miR-499a-5p and NanoString PanCancer analysis, we observed that UA had significant anti-CSC ability.	ursolic acid	156-158	hepatocyte nuclear factor 4 alpha	Homo sapiens	38-45
33278391-4	2021	By using caspase 3/7, ROS, migration, TCF/LEF and CAM assays, overexpressing and inhibiting miR-499a-5p and NanoString PanCancer analysis, we observed that UA had significant anti-CSC ability.	ursolic acid	156-158	microRNA 499a	Homo sapiens	92-100
33278391-6	2021	Furthermore, expression of the oncogenic miR-499a-5p was substantially diminished in CSCs after UA treatment.	ursolic acid	96-98	microRNA 499a	Homo sapiens	41-49
33200293-1	2022	Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives were synthesized and screened for their anti-inflammatory activity by evaluating their inhibition effect of using LPS-induced inflammatory response in RAW 264.7 macrophages in vitro; the effects of different concentrations of the compounds on the secretion of nitric oxide (NO) and inflammatory cytokines including TNF-alpha and IL-6 were evaluated.	ursolic acid	26-38	tumor necrosis factor	Homo sapiens	405-414
33728353-8	2021	Ursolic acid has the ability to modulate the activity of main protease (Mpro) that is essential for processing of SARS-CoV2 replicase-transcriptase machinery needed for viral replication and particle assembly.	ursolic acid	0-12	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	72-76
32942951-0	2020	The anti-tumor effect of ursolic acid on papillary thyroid carcinoma via suppressing Fibronectin-1.	ursolic acid	25-37	fibronectin 1	Homo sapiens	85-98
32942951-5	2020	The effects of overexpressed FN1 on UA-treated cells were detected following the previous procedures.	ursolic acid	36-38	fibronectin 1	Homo sapiens	29-32
32942951-8	2020	Effects of FN1 on cell viability, proliferation, and apoptosis- and EMT-related marker expressions were partially reversed by UA.	ursolic acid	126-128	fibronectin 1	Homo sapiens	11-14
32942951-9	2020	UA inhibited human PTC cell viability, proliferation, and EMT but promoted apoptosis via suppressing FN1.	ursolic acid	0-2	fibronectin 1	Homo sapiens	101-104
32926336-8	2021	Furthermore, ursolic acid as a positive control (IC50 3.42 +- 0.26 microM) and compounds 1 and 5 acted as mixed-competitive inhibitors against PTP1B enzyme with Ki values of 6.46, 10.28, and 15.01 microM, respectively.	ursolic acid	13-25	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	143-148
33065153-4	2020	Firstly through in vivo experiment, we confirmed that UA administration obviously protected against ovariectomy (OVX)-induced osteoporosis in rats by improving microarchitectural deterioration of trabecular bone (P < 0.001), decreasing numbers of TRAP positive osteoclast in vertebra (P < 0.001), as well as decreasing serum osteoclast-specific cytokines release (P < 0.001).	ursolic acid	54-56	tudor domain containing 7	Rattus norvegicus	247-251
33321911-5	2020	UA caused the accumulation of vacuoles and LC3 puncta, a marker of autophagosome, in a dose-dependent manner.	ursolic acid	0-2	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	43-46
33321911-9	2020	UA also significantly inhibited protein kinase B (Akt) activation and increased p-Akt expression in a dose-dependent manner in ESCC cells.	ursolic acid	0-2	protein tyrosine kinase 2 beta	Homo sapiens	32-48
33321911-9	2020	UA also significantly inhibited protein kinase B (Akt) activation and increased p-Akt expression in a dose-dependent manner in ESCC cells.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	50-53
33321911-9	2020	UA also significantly inhibited protein kinase B (Akt) activation and increased p-Akt expression in a dose-dependent manner in ESCC cells.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	82-85
32876525-0	2020	Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue.	ursolic acid	0-12	interleukin 6	Mus musculus	39-42
32876525-6	2020	IL6 and MCP1 levels in the cell culture medium and mouse serum were induced by UA treatment.	ursolic acid	79-81	interleukin 6	Mus musculus	0-3
32876525-6	2020	IL6 and MCP1 levels in the cell culture medium and mouse serum were induced by UA treatment.	ursolic acid	79-81	mast cell protease 1	Mus musculus	8-12
32876525-9	2020	Mechanistically, UA induced the expression of Tlr4 and the phosphorylation levels of ERK and NFkappaB in adipocytes.	ursolic acid	17-19	toll-like receptor 4	Mus musculus	46-50
32876525-9	2020	Mechanistically, UA induced the expression of Tlr4 and the phosphorylation levels of ERK and NFkappaB in adipocytes.	ursolic acid	17-19	mitogen-activated protein kinase 1	Mus musculus	85-88
32876525-9	2020	Mechanistically, UA induced the expression of Tlr4 and the phosphorylation levels of ERK and NFkappaB in adipocytes.	ursolic acid	17-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-101
32876525-10	2020	In conclusion, our study indicated that short-term UA administration could induce CD14+ monocytes infiltration by increasing the production of interleukins and chemokines in mouse adipose tissue, which might further impair glucose tolerance test.	ursolic acid	51-53	CD14 antigen	Mus musculus	82-86
33200293-1	2022	Here, two series of novel ursolic acid-based 1,2,4-triazolo[1,5-a]pyrimidines derivatives were synthesized and screened for their anti-inflammatory activity by evaluating their inhibition effect of using LPS-induced inflammatory response in RAW 264.7 macrophages in vitro; the effects of different concentrations of the compounds on the secretion of nitric oxide (NO) and inflammatory cytokines including TNF-alpha and IL-6 were evaluated.	ursolic acid	26-38	interleukin 6	Homo sapiens	419-423
33001454-9	2020	These results indicated that UA lowered the lipid content probably via activating the AMPK signaling pathway, thereby inhibiting lipid synthesis and promoting fat decomposition.	ursolic acid	29-31	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	86-90
32901853-7	2020	Moreover, the inhibition of autophagy by chloroquine (CQ) or siRNA for autophagy-related gene 5 (ATG5) enhanced the UA-induced inhibition of cell proliferation and promotion of apoptosis, indicating that UA-induced autophagy is a pro-survival mechanism in NSCLC cells.	ursolic acid	116-118	autophagy related 5	Homo sapiens	71-95
32901853-7	2020	Moreover, the inhibition of autophagy by chloroquine (CQ) or siRNA for autophagy-related gene 5 (ATG5) enhanced the UA-induced inhibition of cell proliferation and promotion of apoptosis, indicating that UA-induced autophagy is a pro-survival mechanism in NSCLC cells.	ursolic acid	116-118	autophagy related 5	Homo sapiens	97-101
32901853-7	2020	Moreover, the inhibition of autophagy by chloroquine (CQ) or siRNA for autophagy-related gene 5 (ATG5) enhanced the UA-induced inhibition of cell proliferation and promotion of apoptosis, indicating that UA-induced autophagy is a pro-survival mechanism in NSCLC cells.	ursolic acid	204-206	autophagy related 5	Homo sapiens	71-95
32901853-7	2020	Moreover, the inhibition of autophagy by chloroquine (CQ) or siRNA for autophagy-related gene 5 (ATG5) enhanced the UA-induced inhibition of cell proliferation and promotion of apoptosis, indicating that UA-induced autophagy is a pro-survival mechanism in NSCLC cells.	ursolic acid	204-206	autophagy related 5	Homo sapiens	97-101
33001454-0	2020	Ursolic acid alleviates lipid accumulation by activating the AMPK signaling pathway in vivo and in vitro.	ursolic acid	0-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65
33001454-7	2020	Of note, these protective effects of UA on a high-fat environment were blocked by the AMPK inhibitor (compound C) in vitro.	ursolic acid	37-39	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	86-90
33001454-8	2020	In addition, the molecular docking results suggested that UA could be docked to the AMPK protein as an AMPK activator.	ursolic acid	58-60	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	84-88
33001454-8	2020	In addition, the molecular docking results suggested that UA could be docked to the AMPK protein as an AMPK activator.	ursolic acid	58-60	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	103-107
32934737-9	2020	Additionally, UA exposure significantly decreased MMP-2 production and induced the activation of NLRP3 inflammasome, which was reversed by MCC950 treatment, indicating that NLRP3 activation may be involved in UA inhibition of A498 cell invasiveness.	ursolic acid	14-16	matrix metallopeptidase 2	Homo sapiens	50-55
32921392-0	2020	Ursolic acid treatment suppresses cuprizone-induced demyelination and motor dysfunction via upregulation of IGF-1.	ursolic acid	0-12	insulin like growth factor 1	Homo sapiens	108-113
32921392-4	2020	Oral administration of UA effectively suppressed cuprizone-induced demyelination and motor dysfunction via the enhancement of IGF-1 levels in the demyelinating lesions.	ursolic acid	23-25	insulin like growth factor 1	Homo sapiens	126-131
32934737-0	2020	Ursolic acid inhibits the invasiveness of A498 cells via NLRP3 inflammasome activation.	ursolic acid	0-12	NLR family pyrin domain containing 3	Homo sapiens	57-62
32934737-9	2020	Additionally, UA exposure significantly decreased MMP-2 production and induced the activation of NLRP3 inflammasome, which was reversed by MCC950 treatment, indicating that NLRP3 activation may be involved in UA inhibition of A498 cell invasiveness.	ursolic acid	14-16	NLR family pyrin domain containing 3	Homo sapiens	97-102
32934737-9	2020	Additionally, UA exposure significantly decreased MMP-2 production and induced the activation of NLRP3 inflammasome, which was reversed by MCC950 treatment, indicating that NLRP3 activation may be involved in UA inhibition of A498 cell invasiveness.	ursolic acid	14-16	NLR family pyrin domain containing 3	Homo sapiens	173-178
32934737-9	2020	Additionally, UA exposure significantly decreased MMP-2 production and induced the activation of NLRP3 inflammasome, which was reversed by MCC950 treatment, indicating that NLRP3 activation may be involved in UA inhibition of A498 cell invasiveness.	ursolic acid	209-211	NLR family pyrin domain containing 3	Homo sapiens	97-102
32934737-9	2020	Additionally, UA exposure significantly decreased MMP-2 production and induced the activation of NLRP3 inflammasome, which was reversed by MCC950 treatment, indicating that NLRP3 activation may be involved in UA inhibition of A498 cell invasiveness.	ursolic acid	209-211	NLR family pyrin domain containing 3	Homo sapiens	173-178
32792197-5	2020	We found that B16F1 cells treated with ursolic acid suppressed alpha-melanocyte stimulating hormone (alpha-MSH) stimulated increase in melanin content and activated autophagy.	ursolic acid	39-51	pro-opiomelanocortin-alpha	Mus musculus	63-99
33092305-10	2020	When animals were treated with Glu plus UA, higher leishmanicidal activity was observed in comparison to all groups treated with monotherapy schemes, and such activity was related to lesion improvement and upregulation of IFN-gamma production.	ursolic acid	40-42	interferon gamma	Mus musculus	222-231
33109038-0	2021	Protective Effect of Ursolic Acid in Prunella vulgaris L on LPS-induced asthenozoospermia via Bcl-2/Bax Apoptosis Signaling Pathway.	ursolic acid	21-33	BCL2, apoptosis regulator	Rattus norvegicus	94-99
33109038-0	2021	Protective Effect of Ursolic Acid in Prunella vulgaris L on LPS-induced asthenozoospermia via Bcl-2/Bax Apoptosis Signaling Pathway.	ursolic acid	21-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	100-103
32792197-5	2020	We found that B16F1 cells treated with ursolic acid suppressed alpha-melanocyte stimulating hormone (alpha-MSH) stimulated increase in melanin content and activated autophagy.	ursolic acid	39-51	STAM binding protein	Mus musculus	101-110
32792197-6	2020	In addition, we found that treatment with ursolic acid promotes melanosomal degradation, and bafilomycin A1 inhibition of autophagosome-lysosome fusion blocked the removal of melanosomes in alpha-MSH-stimulated B16F1 cells.	ursolic acid	42-54	STAM binding protein	Mus musculus	190-199
32792197-7	2020	Furthermore, depletion of the autophagy-related gene 5 (ATG5) resulted in significant suppression of ursolic acid-mediated anti-pigmentation activity and autophagy in alpha-MSH-treated B16F1 cells.	ursolic acid	101-113	autophagy related 5	Mus musculus	30-54
32792197-7	2020	Furthermore, depletion of the autophagy-related gene 5 (ATG5) resulted in significant suppression of ursolic acid-mediated anti-pigmentation activity and autophagy in alpha-MSH-treated B16F1 cells.	ursolic acid	101-113	autophagy related 5	Mus musculus	56-60
32880087-0	2020	Retraction Note to: Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFkappaB pathway in streptozocin-induced diabetic rats.	ursolic acid	52-64	advanced glycosylation end product-specific receptor	Rattus norvegicus	73-77
33028983-0	2021	Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo.	ursolic acid	0-12	caspase 3	Mus musculus	121-126
33028983-8	2021	In alcohol-treated HepG2 cells, pretreatment with the UA metabolite (10 muM) irreversibly inhibited CASP3 activities, and subsequently decreased the cleavage of PARP and cell apoptosis.	ursolic acid	54-56	caspase 3	Homo sapiens	100-105
33028983-8	2021	In alcohol-treated HepG2 cells, pretreatment with the UA metabolite (10 muM) irreversibly inhibited CASP3 activities, and subsequently decreased the cleavage of PARP and cell apoptosis.	ursolic acid	54-56	poly(ADP-ribose) polymerase 1	Homo sapiens	161-165
33028983-9	2021	Finally, pre-administration of UA (20-80 mg  kg-1 per day, ig, for 1 week) dose-dependently alleviated alcohol-induced liver injury in mice mainly via the inhibition of CASP3.	ursolic acid	31-33	caspase 3	Mus musculus	169-174
32828361-4	2020	In addition, both plant-derived compounds could induce the resistance responses of tobacco plants against TMV, showing increased antioxidant enzyme activities (SOD and POD) and H2O2 accumulation in tobacco leaves after treatment with UA or 4-methoxycoumarin, along with highly expressed regulatory and defence genes in the salicylic acid signaling pathway.	ursolic acid	234-236	superoxide dismutase 1	Homo sapiens	160-163
32745911-0	2020	Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-kappaB/NLRP3 inflammasome pathway and ameliorates osteoarthritis.	ursolic acid	0-12	NLR family, pyrin domain containing 3	Rattus norvegicus	106-111
32745911-6	2020	The expression of these most-enriched DEGs was reversed by UA following stimulation with TNF-alpha.	ursolic acid	59-61	tumor necrosis factor	Rattus norvegicus	89-98
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	tumor necrosis factor	Rattus norvegicus	71-80
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	synaptotagmin 1	Rattus norvegicus	114-117
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	NFKB inhibitor alpha	Rattus norvegicus	141-153
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	AKT serine/threonine kinase 1	Rattus norvegicus	158-161
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	tumor necrosis factor	Rattus norvegicus	176-185
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	heat shock protein family B (small) member 6	Rattus norvegicus	211-214
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	acyl-CoA synthetase long-chain family member 1	Rattus norvegicus	216-219
32745911-7	2020	Additional investigation demonstrated that treatment with UA inhibited TNF-alpha-induced nuclear translocation of p65 and phosphorylation of IkappaBalpha and AKT, and reversed TNF-alpha-induced up-regulation of P20, ACS and NLRP3.	ursolic acid	58-60	NLR family, pyrin domain containing 3	Rattus norvegicus	224-229
32591414-8	2020	In addition, ursolic acid, gambogic acid, and glycyrrhetic acid, if delivered intravenously, may attain high enough systemic concentrations to significantly inhibit CES1.	ursolic acid	13-25	carboxylesterase 1	Homo sapiens	165-169
32982435-0	2020	Ursolic Acid Protects Against Proliferation and Inflammatory Response in LPS-Treated Gastric Tumour Model and Cells by Inhibiting NLRP3 Inflammasome Activation.	ursolic acid	0-12	NLR family pyrin domain containing 3	Homo sapiens	130-135
32982435-5	2020	This study also aimed to confirm whether ursolic acid can protect against proliferation and the inflammatory response induced by LPS, by inhibiting the activation of the NLRP3 inflammasome via the NF-kappaB pathway.	ursolic acid	41-53	NLR family pyrin domain containing 3	Homo sapiens	170-175
32982435-5	2020	This study also aimed to confirm whether ursolic acid can protect against proliferation and the inflammatory response induced by LPS, by inhibiting the activation of the NLRP3 inflammasome via the NF-kappaB pathway.	ursolic acid	41-53	nuclear factor kappa B subunit 1	Homo sapiens	197-206
32982435-6	2020	Results: The present study demonstrated that ursolic acid significantly attenuated LPS-treated proliferation in a gastric tumour mouse model and the human gastric carcinoma BGC-823 cell line, reduced the expression of the NLRP3 inflammasome and suppressed the release of pro-inflammatory cytokines.	ursolic acid	45-57	NLR family pyrin domain containing 3	Homo sapiens	222-227
32982435-7	2020	In addition, ursolic acid inhibited the LPS-induced activation of NF-kappaB.	ursolic acid	13-25	nuclear factor kappa B subunit 1	Homo sapiens	66-75
32982435-9	2020	Conclusion: In conclusion, these results demonstrated that ursolic acid could suppress proliferation and the inflammatory response in an LPS-induced mouse gastric tumour model and human BGC-823 cells by inhibiting the activation of the NLRP3 inflammasome via the NF-kappaB pathway.	ursolic acid	59-71	NLR family pyrin domain containing 3	Homo sapiens	236-241
32982435-9	2020	Conclusion: In conclusion, these results demonstrated that ursolic acid could suppress proliferation and the inflammatory response in an LPS-induced mouse gastric tumour model and human BGC-823 cells by inhibiting the activation of the NLRP3 inflammasome via the NF-kappaB pathway.	ursolic acid	59-71	nuclear factor kappa B subunit 1	Homo sapiens	263-272
32628284-0	2020	PXR-ABC drug transporters/CYP-mediated ursolic acid transport and metabolism in vitro and vivo.	ursolic acid	39-51	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
32628284-0	2020	PXR-ABC drug transporters/CYP-mediated ursolic acid transport and metabolism in vitro and vivo.	ursolic acid	39-51	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	26-29
32628284-2	2020	Then, the pharmacokinetics features of ursolic acid and the expression of ATP-binding cassette transporters (ABC transporter) and cytochrome P450 (CYP) enzymes in tissues after pregnane X receptor (PXR) activation by 5-pregnen-3beta-ol-20-one-16alpha-carbonitrile (PCN) were investigated in rats.	ursolic acid	39-51	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	198-201
32628284-4	2020	The apparent permeability (PDR) values of 10, 20, and 50 microM ursolic acid in Caco2 cells were 2.19 +- 0.44, 1.40 +- 0.17, and 1.25 +- 0.07, respectively, whereas in Caco2-siRNA-PXR cells, they were 1.85 +- 0.36, 1.24 +- 0.11, and 1.19 +- 0.04, respectively.	ursolic acid	64-76	nuclear receptor subfamily 1 group I member 2	Homo sapiens	180-183
32628284-6	2020	Compared with Caco2 cells, when the concentrations of ursolic acid were 10, 20, and 50 microM, the PDR values increased in Caco2-PXR-RXRalpha cells after PXR activation: 1.60 +- 0.31 versus 1.97 +- 0.21, 1.46 +- 0.08 versus 2.01 +- 0.19, and 1.32 +- 0.26 versus 2.09 +- 0.22, respectively.	ursolic acid	54-66	nuclear receptor subfamily 1 group I member 2	Homo sapiens	129-132
32628284-7	2020	Simultaneously, PXR-RXRalpha would activate the expression of CYP2C9; metabolic kinetics of ursolic acid in CYP metabolizing enzyme lysate of Caco2 cells and Caco2-PXR-RXR cells was studied and it was found that the Km values were 81.99 +- 44.32 and 60.05 +- 29.62 microg/ml, and Vmax values were 3.77 +- 0.86 and 3.41 +- 0.96 microg   ml-1    min-1 , respectively.	ursolic acid	92-104	nuclear receptor subfamily 1 group I member 2	Homo sapiens	16-19
32628284-7	2020	Simultaneously, PXR-RXRalpha would activate the expression of CYP2C9; metabolic kinetics of ursolic acid in CYP metabolizing enzyme lysate of Caco2 cells and Caco2-PXR-RXR cells was studied and it was found that the Km values were 81.99 +- 44.32 and 60.05 +- 29.62 microg/ml, and Vmax values were 3.77 +- 0.86 and 3.41 +- 0.96 microg   ml-1    min-1 , respectively.	ursolic acid	92-104	retinoid X receptor alpha	Homo sapiens	20-28
32628284-7	2020	Simultaneously, PXR-RXRalpha would activate the expression of CYP2C9; metabolic kinetics of ursolic acid in CYP metabolizing enzyme lysate of Caco2 cells and Caco2-PXR-RXR cells was studied and it was found that the Km values were 81.99 +- 44.32 and 60.05 +- 29.62 microg/ml, and Vmax values were 3.77 +- 0.86 and 3.41 +- 0.96 microg   ml-1    min-1 , respectively.	ursolic acid	92-104	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	62-68
32628284-7	2020	Simultaneously, PXR-RXRalpha would activate the expression of CYP2C9; metabolic kinetics of ursolic acid in CYP metabolizing enzyme lysate of Caco2 cells and Caco2-PXR-RXR cells was studied and it was found that the Km values were 81.99 +- 44.32 and 60.05 +- 29.62 microg/ml, and Vmax values were 3.77 +- 0.86 and 3.41 +- 0.96 microg   ml-1    min-1 , respectively.	ursolic acid	92-104	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	62-65
32628284-7	2020	Simultaneously, PXR-RXRalpha would activate the expression of CYP2C9; metabolic kinetics of ursolic acid in CYP metabolizing enzyme lysate of Caco2 cells and Caco2-PXR-RXR cells was studied and it was found that the Km values were 81.99 +- 44.32 and 60.05 +- 29.62 microg/ml, and Vmax values were 3.77 +- 0.86 and 3.41 +- 0.96 microg   ml-1    min-1 , respectively.	ursolic acid	92-104	interleukin 17F	Homo sapiens	336-349
32628284-8	2020	However, in human CYP metabolizing recombinase, we found that both CYP2C9 and CYP34A were involved in the metabolism of ursolic acid.	ursolic acid	120-132	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	18-21
32628284-8	2020	However, in human CYP metabolizing recombinase, we found that both CYP2C9 and CYP34A were involved in the metabolism of ursolic acid.	ursolic acid	120-132	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	67-73
32626955-0	2020	Ursolic acid protects against cisplatin-induced ototoxicity by inhibiting oxidative stress and TRPV1-mediated Ca2+-signaling.	ursolic acid	0-12	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	ursolic acid	80-92	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32542667-7	2020	The effect of a combination with two natural compounds, oleanolic acid (OA) and ursolic acid (UA), was evaluated on the expression of the IL-8 axis and epithelial cell growth.	ursolic acid	94-96	C-X-C motif chemokine ligand 8	Homo sapiens	138-142
32626955-9	2020	UA co-treatment significantly attenuated CDDP-induced hearing loss and inhibited TRPV1 pathway activation.	ursolic acid	0-2	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
32626955-11	2020	Collectively, the present data suggested that UA could effectively attenuate CDDP-induced hearing loss by inhibiting the TRPV1/Ca2+/calpain-oxidative stress pathway without impairing the antitumor effects of CDDP.	ursolic acid	46-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-126
32185829-7	2020	High RAGE expression in MIA Paca-2GEMR cells was suppressed by UA treatment.	ursolic acid	63-65	advanced glycosylation end-product specific receptor	Homo sapiens	5-9
32185829-8	2020	Interestingly, knocking down RAGE expression showed similar UA-induced effects in both cell lines.	ursolic acid	60-62	advanced glycosylation end-product specific receptor	Homo sapiens	29-33
32774413-11	2020	The positive effects on liver regeneration were found in both the gCD and HAP forms of ursolic acid, whose effects were confirmed through the upregulation of HGF.	ursolic acid	87-99	hepatocyte growth factor	Rattus norvegicus	158-161
32551573-0	2020	The anti-proliferative activity of ursolic acid in MDA-MB-231 human breast cancer cells through Nrf2 pathway regulation.	ursolic acid	35-47	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
32551573-1	2020	The potential mechanisms of action of ursolic acid (UA) in regulating cell proliferation in MDA-MB-231 human breast cancer cells through Nrf2 pathway were investigated.	ursolic acid	38-50	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
32551573-1	2020	The potential mechanisms of action of ursolic acid (UA) in regulating cell proliferation in MDA-MB-231 human breast cancer cells through Nrf2 pathway were investigated.	ursolic acid	52-54	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
32551573-3	2020	The expressions of Nrf2 and p-Nrf2 in whole cell and nucleus, and NQO1 were inhibited by UA treatment, while the Keap1 expression was upregulated.	ursolic acid	89-91	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
32551573-3	2020	The expressions of Nrf2 and p-Nrf2 in whole cell and nucleus, and NQO1 were inhibited by UA treatment, while the Keap1 expression was upregulated.	ursolic acid	89-91	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
32551573-3	2020	The expressions of Nrf2 and p-Nrf2 in whole cell and nucleus, and NQO1 were inhibited by UA treatment, while the Keap1 expression was upregulated.	ursolic acid	89-91	NAD(P)H quinone dehydrogenase 1	Homo sapiens	66-70
32551573-7	2020	These results suggested that the proliferative inhibitory effect of UA might be partially through down-regulating Nrf2 via Keap1/Nrf2 pathway and EGFR/Nrf2 pathway in MDA-MB-231 cells.	ursolic acid	68-70	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
32551573-7	2020	These results suggested that the proliferative inhibitory effect of UA might be partially through down-regulating Nrf2 via Keap1/Nrf2 pathway and EGFR/Nrf2 pathway in MDA-MB-231 cells.	ursolic acid	68-70	kelch like ECH associated protein 1	Homo sapiens	123-128
32551573-7	2020	These results suggested that the proliferative inhibitory effect of UA might be partially through down-regulating Nrf2 via Keap1/Nrf2 pathway and EGFR/Nrf2 pathway in MDA-MB-231 cells.	ursolic acid	68-70	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
32551573-7	2020	These results suggested that the proliferative inhibitory effect of UA might be partially through down-regulating Nrf2 via Keap1/Nrf2 pathway and EGFR/Nrf2 pathway in MDA-MB-231 cells.	ursolic acid	68-70	epidermal growth factor receptor	Homo sapiens	146-150
32551573-7	2020	These results suggested that the proliferative inhibitory effect of UA might be partially through down-regulating Nrf2 via Keap1/Nrf2 pathway and EGFR/Nrf2 pathway in MDA-MB-231 cells.	ursolic acid	68-70	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
32617130-3	2020	UA-pretreated human skin dermal fibroblast (HDF) cells were exposed to UVB radiation to evaluated cell viability, reactive oxygen species (ROS), mitochondrial membrane potential, lipid peroxidation, antioxidant status, DNA damage, proinflammatory response, apoptotic induction, and matrix metalloproteinase (MMP) alteration.	ursolic acid	0-2	matrix metallopeptidase 2	Homo sapiens	308-311
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	tumor necrosis factor	Homo sapiens	84-93
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	nuclear factor kappa B subunit 1	Homo sapiens	98-107
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	tumor protein p53	Homo sapiens	124-127
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	caspase 3	Homo sapiens	138-147
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	matrix metallopeptidase 2	Homo sapiens	159-164
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	matrix metallopeptidase 9	Homo sapiens	169-174
32617130-5	2020	UA pretreatment of HDFs also attenuated the UVB-induced expression of inflammatory (TNF-alpha and NF-kappaB) and apoptotic (p53, Bax, and caspase-3) and MMPs (MMP-2 and MMP-9) and enhanced the Bcl-2 protein levels in 20 muM UA treatment, when compared to concentrations.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	193-198
32496208-0	2020	Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.	ursolic acid	0-12	NADPH oxidase 4	Mus musculus	63-67
32545262-4	2020	Ursolic acid and 3-O-acetylursolic acid have shown similar GI50 on A375 cells (26 microM vs. 32 microM, respectively) significantly increased both early and late apoptotic populations, activated caspases 3/7 (48-72 h), and enhanced Bax whilst attenuating Bcl-2 expression.	ursolic acid	0-12	caspase 3	Homo sapiens	195-207
32545262-4	2020	Ursolic acid and 3-O-acetylursolic acid have shown similar GI50 on A375 cells (26 microM vs. 32 microM, respectively) significantly increased both early and late apoptotic populations, activated caspases 3/7 (48-72 h), and enhanced Bax whilst attenuating Bcl-2 expression.	ursolic acid	0-12	BCL2-associated X protein	Mus musculus	232-235
32545262-4	2020	Ursolic acid and 3-O-acetylursolic acid have shown similar GI50 on A375 cells (26 microM vs. 32 microM, respectively) significantly increased both early and late apoptotic populations, activated caspases 3/7 (48-72 h), and enhanced Bax whilst attenuating Bcl-2 expression.	ursolic acid	0-12	B cell leukemia/lymphoma 2	Mus musculus	255-260
32448034-3	2021	In the current study, we report novel natural metabolites namely, ursolic acid, carvacrol and oleanolic acid as the potential inhibitors against main protease (Mpro) of COVID-19 by using integrated molecular modeling approaches.	ursolic acid	66-78	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	160-164
32448034-8	2021	ursolic acid, carvacrol and oleanolic acid could serve as potential inhibitors in regulating the Mpro protein"s function and controlling viral replication.	ursolic acid	0-12	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	97-101
32496208-0	2020	Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.	ursolic acid	0-12	ras homolog family member A	Mus musculus	76-80
32496208-0	2020	Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.	ursolic acid	0-12	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	81-86
32496208-5	2020	First, we confirmed that UA reversed CCl4-induced liver fibrosis.	ursolic acid	25-27	chemokine (C-C motif) ligand 4	Mus musculus	37-41
32496208-7	2020	Next, we determined that the expression of NOX4 and RhoA/ROCK1 was decreased in UA-treated liver fibrotic mice.	ursolic acid	80-82	NADPH oxidase 4	Mus musculus	43-47
32496208-7	2020	Next, we determined that the expression of NOX4 and RhoA/ROCK1 was decreased in UA-treated liver fibrotic mice.	ursolic acid	80-82	ras homolog family member A	Mus musculus	52-56
32496208-7	2020	Next, we determined that the expression of NOX4 and RhoA/ROCK1 was decreased in UA-treated liver fibrotic mice.	ursolic acid	80-82	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	57-62
32496208-12	2020	UA can reverse liver fibrosis by inhibiting the NOX4/ROS and RhoA/ROCK1 signalling pathways, which may interact with each other.	ursolic acid	0-2	NADPH oxidase 4	Mus musculus	48-52
32496208-12	2020	UA can reverse liver fibrosis by inhibiting the NOX4/ROS and RhoA/ROCK1 signalling pathways, which may interact with each other.	ursolic acid	0-2	ras homolog family member A	Mus musculus	61-65
32496208-12	2020	UA can reverse liver fibrosis by inhibiting the NOX4/ROS and RhoA/ROCK1 signalling pathways, which may interact with each other.	ursolic acid	0-2	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	66-71
32141989-8	2020	UA also attenuated the Phenylephrine-induced hypertrophy of neonatal rat ventricular myocytes and upregulated peroxisome proliferator-activated receptor-alpha (PPARalpha), a key fatty acid metabolism regulator, and its downstream factor carnitine palmitoyl transferase 1b.	ursolic acid	0-2	peroxisome proliferator activated receptor alpha	Rattus norvegicus	110-158
31855318-0	2020	The miRNA-149-5p/MyD88 axis is responsible for ursolic acid-mediated attenuation of the stemness and chemoresistance of non-small cell lung cancer cells.	ursolic acid	47-59	MYD88 innate immune signal transduction adaptor	Homo sapiens	17-22
32141989-8	2020	UA also attenuated the Phenylephrine-induced hypertrophy of neonatal rat ventricular myocytes and upregulated peroxisome proliferator-activated receptor-alpha (PPARalpha), a key fatty acid metabolism regulator, and its downstream factor carnitine palmitoyl transferase 1b.	ursolic acid	0-2	peroxisome proliferator activated receptor alpha	Rattus norvegicus	160-169
32141989-8	2020	UA also attenuated the Phenylephrine-induced hypertrophy of neonatal rat ventricular myocytes and upregulated peroxisome proliferator-activated receptor-alpha (PPARalpha), a key fatty acid metabolism regulator, and its downstream factor carnitine palmitoyl transferase 1b.	ursolic acid	0-2	carnitine palmitoyltransferase 1B	Rattus norvegicus	237-271
32141989-9	2020	In conclusion, UA exerts beneficial effects on PAH-induced RV dysfunction and remodeling by regulating PPARalpha-dependent fatty acid metabolism.	ursolic acid	15-17	peroxisome proliferator activated receptor alpha	Rattus norvegicus	103-112
32539919-4	2020	A combination of UA and Oxa induced apoptosis in RKO cells and increased the activities of caspase-3, caspase-8, and caspase-9.	ursolic acid	17-19	caspase 3	Homo sapiens	91-100
32539919-4	2020	A combination of UA and Oxa induced apoptosis in RKO cells and increased the activities of caspase-3, caspase-8, and caspase-9.	ursolic acid	17-19	caspase 8	Homo sapiens	102-111
32539919-4	2020	A combination of UA and Oxa induced apoptosis in RKO cells and increased the activities of caspase-3, caspase-8, and caspase-9.	ursolic acid	17-19	caspase 9	Homo sapiens	117-126
32539919-5	2020	Z-VAD-FMK, a caspase inhibitor, significantly antagonized UA- and Oxa-activated caspase-3, caspase-8, and caspase-9 and induced apoptosis.	ursolic acid	58-60	caspase 8	Homo sapiens	13-20
32539919-5	2020	Z-VAD-FMK, a caspase inhibitor, significantly antagonized UA- and Oxa-activated caspase-3, caspase-8, and caspase-9 and induced apoptosis.	ursolic acid	58-60	caspase 3	Homo sapiens	80-89
32539919-6	2020	In addition, UA and Oxa downregulated the expression of X-linked inhibitor of apoptosis (XIAP) and Survivin in RKO cells.	ursolic acid	13-15	X-linked inhibitor of apoptosis	Homo sapiens	56-87
32539919-6	2020	In addition, UA and Oxa downregulated the expression of X-linked inhibitor of apoptosis (XIAP) and Survivin in RKO cells.	ursolic acid	13-15	X-linked inhibitor of apoptosis	Homo sapiens	89-93
32523377-9	2020	Conclusion: Our data indicated that the anti-tumor effects of UA are due to the inhibited RAF/ERK pathway and IKK/NF-kappaB pathway.	ursolic acid	62-64	zinc fingers and homeoboxes 2	Homo sapiens	90-93
32523377-9	2020	Conclusion: Our data indicated that the anti-tumor effects of UA are due to the inhibited RAF/ERK pathway and IKK/NF-kappaB pathway.	ursolic acid	62-64	mitogen-activated protein kinase 1	Homo sapiens	94-97
30580622-7	2020	Specifically, ursolic acid and oleanolic acid showed better ACE inhibition than the other compounds.	ursolic acid	14-26	angiotensin I converting enzyme	Rattus norvegicus	60-63
31855318-4	2020	Mechanistic investigations revealed that UA inhibited the miR-149-5p/MyD88 signaling, which is responsible for UA-mediated effects on the stemness of A549-PR cells.	ursolic acid	41-43	MYD88 innate immune signal transduction adaptor	Homo sapiens	69-74
31855318-4	2020	Mechanistic investigations revealed that UA inhibited the miR-149-5p/MyD88 signaling, which is responsible for UA-mediated effects on the stemness of A549-PR cells.	ursolic acid	111-113	MYD88 innate immune signal transduction adaptor	Homo sapiens	69-74
31855318-6	2020	Therefore, these results suggest that UA could attenuate the stemness and chemoresistance of NSCLC cells through targeting miR-149-5p/MyD88 axis.	ursolic acid	38-40	MYD88 innate immune signal transduction adaptor	Homo sapiens	134-139
31981747-11	2020	The in vitro studies showed that quercetin and ursolic acid, the active components of XJR, could effectively inhibit the proliferation of breast cancer cells, and the combination of the two components could significantly decrease the mitochondrial membrane potential and suppress the activation of PI3K-Akt signaling pathway, thus inducing apoptosis of cancer cells.	ursolic acid	47-59	AKT serine/threonine kinase 1	Homo sapiens	303-306
31926193-1	2020	Ursolic acid (UA) is a potent triterpenoid compound found in plants and fruits with activities modulating key cell signaling pathways involving STATs, NF-kappaB, and TRAIL.	ursolic acid	0-12	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	166-171
31926193-1	2020	Ursolic acid (UA) is a potent triterpenoid compound found in plants and fruits with activities modulating key cell signaling pathways involving STATs, NF-kappaB, and TRAIL.	ursolic acid	14-16	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	166-171
31926193-6	2020	While the UA-liposomes were not generally toxic towards 4T1 triple negative breast cancer cells, they could effectively modulate CD4+CD25+Foxp3+ T cells from 4T1 tumor bearing mouse by inhibiting STAT5 phosphorylation and IL-10 secretion.	ursolic acid	10-12	CD4 antigen	Mus musculus	129-132
31926193-6	2020	While the UA-liposomes were not generally toxic towards 4T1 triple negative breast cancer cells, they could effectively modulate CD4+CD25+Foxp3+ T cells from 4T1 tumor bearing mouse by inhibiting STAT5 phosphorylation and IL-10 secretion.	ursolic acid	10-12	signal transducer and activator of transcription 5A	Mus musculus	196-201
31926193-6	2020	While the UA-liposomes were not generally toxic towards 4T1 triple negative breast cancer cells, they could effectively modulate CD4+CD25+Foxp3+ T cells from 4T1 tumor bearing mouse by inhibiting STAT5 phosphorylation and IL-10 secretion.	ursolic acid	10-12	interleukin 10	Mus musculus	222-227
32521863-0	2020	Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway.	ursolic acid	23-35	AKT serine/threonine kinase 1	Homo sapiens	147-150
31845520-9	2020	Oleanolic acid and ursolic acid from Ligustri Lucidi Fructus were chosen as ADA inhibitors with half maximal inhibitory concentration values of 21.82 +- 0.39 and 18.41 +- 0.14 mum, respectively.	ursolic acid	19-31	adenosine deaminase	Homo sapiens	76-79
32521863-7	2020	Further, western blot assay was used to study effects of ursolic acid on the apoptosis-related protein expressions including Bax, Bcl-2 as well as PI3K/AKT signalling pathway.	ursolic acid	57-69	family with sequence similarity 215 member A	Homo sapiens	77-102
32521863-7	2020	Further, western blot assay was used to study effects of ursolic acid on the apoptosis-related protein expressions including Bax, Bcl-2 as well as PI3K/AKT signalling pathway.	ursolic acid	57-69	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
32521863-10	2020	Ursolic acid inhibited the viability of cancer cells via induction of apoptotic cell death which was associated with increase in Bax and decrease in Bcl-2 levels.	ursolic acid	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
32521863-10	2020	Ursolic acid inhibited the viability of cancer cells via induction of apoptotic cell death which was associated with increase in Bax and decrease in Bcl-2 levels.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	149-154
32521863-13	2020	Western blot analysis revealed that ursolic acid had the potential to inhibit I3K/AKT signalling pathway.	ursolic acid	36-48	AKT serine/threonine kinase 1	Homo sapiens	82-85
31997265-7	2020	OB (100 and 200 muL/kg) and UA significantly attenuated the EB-induced neuroinflammation in terms of increase in the levels of pro-inflammatory cytokines (TNF-alpha and IL-6) in the rat PFC.	ursolic acid	28-30	tumor necrosis factor	Rattus norvegicus	155-164
31747348-12	2020	UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1beta and IL-6, concomitantly increasing adiponectin levels.	ursolic acid	0-2	C-C motif chemokine ligand 2	Rattus norvegicus	135-140
31747348-12	2020	UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1beta and IL-6, concomitantly increasing adiponectin levels.	ursolic acid	0-2	C-C motif chemokine ligand 2	Rattus norvegicus	142-176
31747348-12	2020	UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1beta and IL-6, concomitantly increasing adiponectin levels.	ursolic acid	0-2	interleukin 1 beta	Rattus norvegicus	179-201
31747348-12	2020	UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1beta and IL-6, concomitantly increasing adiponectin levels.	ursolic acid	0-2	interleukin 6	Rattus norvegicus	206-210
31747348-12	2020	UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1beta and IL-6, concomitantly increasing adiponectin levels.	ursolic acid	0-2	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	237-248
31997265-7	2020	OB (100 and 200 muL/kg) and UA significantly attenuated the EB-induced neuroinflammation in terms of increase in the levels of pro-inflammatory cytokines (TNF-alpha and IL-6) in the rat PFC.	ursolic acid	28-30	interleukin 6	Rattus norvegicus	169-173
31997265-8	2020	Further, OB (100 and 200 muL/kg) and UA significantly attenuated the EB-induced astrogliosis in terms of increase in the levels of GFAP (Glial fibrillary acidic protein) and Iba-1 (Ionized calcium binding adaptor molecule-1) in the rat PFC.	ursolic acid	37-39	glial fibrillary acidic protein	Rattus norvegicus	131-135
31997265-8	2020	Further, OB (100 and 200 muL/kg) and UA significantly attenuated the EB-induced astrogliosis in terms of increase in the levels of GFAP (Glial fibrillary acidic protein) and Iba-1 (Ionized calcium binding adaptor molecule-1) in the rat PFC.	ursolic acid	37-39	glial fibrillary acidic protein	Rattus norvegicus	137-168
31997265-8	2020	Further, OB (100 and 200 muL/kg) and UA significantly attenuated the EB-induced astrogliosis in terms of increase in the levels of GFAP (Glial fibrillary acidic protein) and Iba-1 (Ionized calcium binding adaptor molecule-1) in the rat PFC.	ursolic acid	37-39	allograft inflammatory factor 1	Rattus norvegicus	174-179
31997265-8	2020	Further, OB (100 and 200 muL/kg) and UA significantly attenuated the EB-induced astrogliosis in terms of increase in the levels of GFAP (Glial fibrillary acidic protein) and Iba-1 (Ionized calcium binding adaptor molecule-1) in the rat PFC.	ursolic acid	37-39	allograft inflammatory factor 1	Rattus norvegicus	181-223
31650545-3	2020	This study aimed to explore the inhibitory effect and interaction mechanism of ursolic acid against alpha-amylase and alpha-glucosidase.	ursolic acid	79-91	sucrase isomaltase (alpha-glucosidase)	Mus musculus	118-135
31650545-5	2020	The half-maximal inhibitory concentration (IC50 ) of ursolic acid on alpha-amylase and alpha-glucosidase was (0.482 +- 0.12) mg mL-1 and (0.213 +- 0.042) mg mL-1 , respectively.	ursolic acid	53-65	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
31650545-5	2020	The half-maximal inhibitory concentration (IC50 ) of ursolic acid on alpha-amylase and alpha-glucosidase was (0.482 +- 0.12) mg mL-1 and (0.213 +- 0.042) mg mL-1 , respectively.	ursolic acid	53-65	L1 cell adhesion molecule	Mus musculus	157-161
31650545-5	2020	The half-maximal inhibitory concentration (IC50 ) of ursolic acid on alpha-amylase and alpha-glucosidase was (0.482 +- 0.12) mg mL-1 and (0.213 +- 0.042) mg mL-1 , respectively.	ursolic acid	53-65	L1 cell adhesion molecule	Mus musculus	128-132
31650545-6	2020	The results of enzymatic kinetics showed that ursolic acid inhibited alpha-amylase and alpha-glucosidase activity in a noncompetitive manner.	ursolic acid	46-58	sucrase isomaltase (alpha-glucosidase)	Mus musculus	87-104
31650545-9	2020	Molecular docking results showed that ursolic acid bound to the inactive site of alpha-amylase and alpha-glucosidase through the formation of ursolic acid-glucosidase complex.	ursolic acid	38-50	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
32787765-10	2020	RESULTS: The results obtained in our study have suggested that UA significantly reduced the overexpression of alpha-Synuclein and regulated the phosphorylation of survival-related kinases (Akt and ERK) apart from alleviating the behavioral abnormalities and protecting the dopaminergic neurons from oxidative stress and neuroinflammation.	ursolic acid	63-65	synuclein, alpha	Mus musculus	110-125
31650545-9	2020	Molecular docking results showed that ursolic acid bound to the inactive site of alpha-amylase and alpha-glucosidase through the formation of ursolic acid-glucosidase complex.	ursolic acid	142-154	sucrase isomaltase (alpha-glucosidase)	Mus musculus	99-116
31650545-10	2020	Ursolic acid interacted with alpha-amylase and alpha-glucosidase mainly through hydrogen bonding.	ursolic acid	0-12	sucrase isomaltase (alpha-glucosidase)	Mus musculus	47-64
31533605-0	2020	Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-alpha during high-intensity resistance training in low activity men.	ursolic acid	21-33	fibronectin type III domain containing 5	Homo sapiens	67-73
31533605-0	2020	Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-alpha during high-intensity resistance training in low activity men.	ursolic acid	21-33	C-reactive protein	Homo sapiens	75-93
31533605-0	2020	Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-alpha during high-intensity resistance training in low activity men.	ursolic acid	21-33	interleukin 6	Homo sapiens	95-99
31533605-0	2020	Synergism effects of ursolic acid supplementation on the levels of irisin, C-reactive protein, IL-6, and TNF-alpha during high-intensity resistance training in low activity men.	ursolic acid	21-33	tumor necrosis factor	Homo sapiens	105-114
31533605-3	2020	OBJECTIVE: Current research was designed to show the effect of high-intensity resistance training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6, and TNF-alpha in the low activity men.	ursolic acid	135-137	fibronectin type III domain containing 5	Homo sapiens	161-167
31533605-8	2020	RESULTS: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p&lt;0.05).	ursolic acid	9-11	fibronectin type III domain containing 5	Homo sapiens	73-79
31533605-8	2020	RESULTS: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p&lt;0.05).	ursolic acid	92-94	fibronectin type III domain containing 5	Homo sapiens	73-79
31533605-9	2020	UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-alpha in the HIRT+UA group versus the HIRT+P group (p&lt;0.05).	ursolic acid	0-2	C-reactive protein	Homo sapiens	62-65
31533605-9	2020	UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-alpha in the HIRT+UA group versus the HIRT+P group (p&lt;0.05).	ursolic acid	0-2	interleukin 6	Homo sapiens	67-71
31533605-9	2020	UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-alpha in the HIRT+UA group versus the HIRT+P group (p&lt;0.05).	ursolic acid	0-2	tumor necrosis factor	Homo sapiens	77-86
31533605-9	2020	UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-alpha in the HIRT+UA group versus the HIRT+P group (p&lt;0.05).	ursolic acid	99-101	tumor necrosis factor	Homo sapiens	77-86
31533605-10	2020	CONCLUSION: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-alpha may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.	ursolic acid	41-43	fibronectin type III domain containing 5	Homo sapiens	73-79
31533605-10	2020	CONCLUSION: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-alpha may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.	ursolic acid	41-43	C-reactive protein	Homo sapiens	97-100
31533605-10	2020	CONCLUSION: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-alpha may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.	ursolic acid	41-43	interleukin 6	Homo sapiens	102-106
31533605-10	2020	CONCLUSION: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-alpha may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.	ursolic acid	41-43	tumor necrosis factor	Homo sapiens	112-121
32787765-10	2020	RESULTS: The results obtained in our study have suggested that UA significantly reduced the overexpression of alpha-Synuclein and regulated the phosphorylation of survival-related kinases (Akt and ERK) apart from alleviating the behavioral abnormalities and protecting the dopaminergic neurons from oxidative stress and neuroinflammation.	ursolic acid	63-65	thymoma viral proto-oncogene 1	Mus musculus	189-192
32787765-10	2020	RESULTS: The results obtained in our study have suggested that UA significantly reduced the overexpression of alpha-Synuclein and regulated the phosphorylation of survival-related kinases (Akt and ERK) apart from alleviating the behavioral abnormalities and protecting the dopaminergic neurons from oxidative stress and neuroinflammation.	ursolic acid	63-65	mitogen-activated protein kinase 1	Mus musculus	197-200
31527378-3	2020	Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression.	ursolic acid	20-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
31527378-3	2020	Here, we identified ursolic acid (UA) as a natural inhibitor of COX-2 and investigated its effects on endometriosis progression.	ursolic acid	34-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	64-69
31527378-8	2020	RESULTS: UA significantly decreased cell viability, inhibited proliferation, and increased caspase-3 activity in a dose-dependent manner.	ursolic acid	9-11	caspase 3	Homo sapiens	91-100
31527378-10	2020	Meanwhile, UA exposure decreased VEGF secretion in the stromal cells and the capillary-tubule formation assay confirmed the inhibitory effect of UA on angiogenesis.	ursolic acid	11-13	vascular endothelial growth factor A	Homo sapiens	33-37
31527378-11	2020	Furthermore, UA increased the phosphorylation of c-Jun N-terminal kinase and p38.	ursolic acid	13-15	mitogen-activated protein kinase 14	Homo sapiens	77-80
31527378-12	2020	CONCLUSIONS: Our data suggest that UA plays a role as a natural inhibitor of COX-2 to control the survival of human endometriotic stromal cells by inhibiting proliferation and angiogenesis and promoting apoptosis.	ursolic acid	35-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	77-82
31849504-0	2019	Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.	ursolic acid	0-12	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	75-80
31622615-3	2020	Ursolic acid hydrazide provided access to oxadiazoles attached directly to C-17 of the ursane core, but synthesis of structurally related 3-mercapto-1,2,4-triazoles was not possible in this way due to steric hindrance of the triterpenoid.	ursolic acid	0-22	cytokine like 1	Homo sapiens	75-79
31849504-0	2019	Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.	ursolic acid	0-12	angiotensin II, type I receptor-associated protein	Mus musculus	81-85
31849504-1	2019	Purpose: This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein (ARAP1)/angiotensin II type 1 receptor (AT1R) signaling pathway and subsequently alleviating renal damage.	ursolic acid	49-61	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	196-201
31849504-1	2019	Purpose: This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein (ARAP1)/angiotensin II type 1 receptor (AT1R) signaling pathway and subsequently alleviating renal damage.	ursolic acid	49-61	angiotensin II, type I receptor-associated protein	Mus musculus	235-239
31849504-1	2019	Purpose: This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein (ARAP1)/angiotensin II type 1 receptor (AT1R) signaling pathway and subsequently alleviating renal damage.	ursolic acid	63-65	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	196-201
31849504-1	2019	Purpose: This study aimed to investigate whether ursolic acid (UA) mitigates renal inflammation, oxidative stress and fibrosis by regulating the angiotensin II type 1 receptor-associated protein (ARAP1)/angiotensin II type 1 receptor (AT1R) signaling pathway and subsequently alleviating renal damage.	ursolic acid	63-65	angiotensin II, type I receptor-associated protein	Mus musculus	235-239
31849504-9	2019	Histochemical analysis results showed significantly lower expression levels of ARAP1, AT1R, FN, NOX2, 8-OHdG, IL-1beta and IL-18 in renal tissues in the UA treatment group than in the DN group.	ursolic acid	153-155	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	79-84
31849504-9	2019	Histochemical analysis results showed significantly lower expression levels of ARAP1, AT1R, FN, NOX2, 8-OHdG, IL-1beta and IL-18 in renal tissues in the UA treatment group than in the DN group.	ursolic acid	153-155	angiotensin II, type I receptor-associated protein	Mus musculus	86-90
31849504-9	2019	Histochemical analysis results showed significantly lower expression levels of ARAP1, AT1R, FN, NOX2, 8-OHdG, IL-1beta and IL-18 in renal tissues in the UA treatment group than in the DN group.	ursolic acid	153-155	cytochrome b-245, beta polypeptide	Mus musculus	96-100
31849504-9	2019	Histochemical analysis results showed significantly lower expression levels of ARAP1, AT1R, FN, NOX2, 8-OHdG, IL-1beta and IL-18 in renal tissues in the UA treatment group than in the DN group.	ursolic acid	153-155	interleukin 1 beta	Mus musculus	110-118
31849504-9	2019	Histochemical analysis results showed significantly lower expression levels of ARAP1, AT1R, FN, NOX2, 8-OHdG, IL-1beta and IL-18 in renal tissues in the UA treatment group than in the DN group.	ursolic acid	153-155	interleukin 18	Mus musculus	123-128
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	96-101
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	angiotensin II receptor, type 1a	Mus musculus	103-106
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	NADPH oxidase 4	Mus musculus	108-112
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	cytochrome b-245, beta polypeptide	Mus musculus	114-118
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	transforming growth factor, beta 1	Mus musculus	120-129
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	fibronectin 1	Mus musculus	131-133
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	interleukin 1 beta	Mus musculus	148-156
31849504-10	2019	Western blotting and RT-qPCR data also revealed UA-induced decreases in the renal levels of the ARAP1, AT1, NOX4, NOX2, TGF-beta1, FN, collagen IV, IL-1beta and IL-18 proteins in vivo and/or in vitro (p&lt;0.01).	ursolic acid	48-50	interleukin 18	Mus musculus	161-166
31849504-12	2019	Conclusion: UA alleviated renal damage in type 2 diabetic db/db mice by downregulating proteins in the ARAP1/AT1R signaling pathway to inhibit extracellular matrix accumulation, renal inflammation, fibrosis and oxidative stress.	ursolic acid	12-14	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mus musculus	103-108
31849504-12	2019	Conclusion: UA alleviated renal damage in type 2 diabetic db/db mice by downregulating proteins in the ARAP1/AT1R signaling pathway to inhibit extracellular matrix accumulation, renal inflammation, fibrosis and oxidative stress.	ursolic acid	12-14	angiotensin II, type I receptor-associated protein	Mus musculus	109-113
31366257-0	2019	Co-delivery of Bmi1 small interfering RNA with ursolic acid by folate receptor-targeted cationic liposomes enhances anti-tumor activity of ursolic acid in vitro and in vivo.	ursolic acid	139-151	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	15-19
31322286-0	2019	Ursolic Acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in NSCLCs harboring EGFR T790M.	ursolic acid	0-12	cancer/testis antigen family 45 member A2	Homo sapiens	76-82
31322286-0	2019	Ursolic Acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in NSCLCs harboring EGFR T790M.	ursolic acid	0-12	epidermal growth factor receptor	Homo sapiens	119-123
31322286-12	2019	Moreover, UA significantly induces apoptosis and inhibits the proliferation of H1975 cells by negatively regulating the beta-catenin/TCF4/CT45A2 signaling pathway.	ursolic acid	10-12	catenin beta 1	Homo sapiens	120-132
31322286-12	2019	Moreover, UA significantly induces apoptosis and inhibits the proliferation of H1975 cells by negatively regulating the beta-catenin/TCF4/CT45A2 signaling pathway.	ursolic acid	10-12	transcription factor 4	Homo sapiens	133-137
31322286-12	2019	Moreover, UA significantly induces apoptosis and inhibits the proliferation of H1975 cells by negatively regulating the beta-catenin/TCF4/CT45A2 signaling pathway.	ursolic acid	10-12	cancer/testis antigen family 45 member A2	Homo sapiens	138-144
31322286-13	2019	Therefore, UA may be a potential candidate for NSCLC harboring EGFR-L858R/T790M mutation therapy.	ursolic acid	11-13	epidermal growth factor receptor	Homo sapiens	63-67
30905239-9	2019	However, UA treatment significantly reduced collagen I and fibronectin accumulation in the fibrotic kidney.	ursolic acid	9-11	fibronectin 1	Mus musculus	59-70
31072147-0	2019	Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors.	ursolic acid	79-91	mitogen-activated protein kinase kinase 7	Homo sapiens	155-158
30905239-10	2019	UA treatment also decreased alpha-SMA and preserved E-cadherin in vivo.	ursolic acid	0-2	actin alpha 2, smooth muscle, aorta	Mus musculus	28-37
30905239-10	2019	UA treatment also decreased alpha-SMA and preserved E-cadherin in vivo.	ursolic acid	0-2	cadherin 1	Mus musculus	52-62
30905239-12	2019	UA pretreatment prevented E-cadherin loss and diminished alpha-SMA expression in HK-2 cells.	ursolic acid	0-2	cadherin 1	Mus musculus	26-36
30905239-12	2019	UA pretreatment prevented E-cadherin loss and diminished alpha-SMA expression in HK-2 cells.	ursolic acid	0-2	actin alpha 2, smooth muscle, aorta	Mus musculus	57-66
30905239-14	2019	UA also lowered TGF-beta1 protein expression and p-Smad3 in HK-2 cells.	ursolic acid	0-2	transforming growth factor, beta 1	Mus musculus	16-25
30905239-14	2019	UA also lowered TGF-beta1 protein expression and p-Smad3 in HK-2 cells.	ursolic acid	0-2	SMAD family member 3	Mus musculus	51-56
31713091-7	2019	Inhibition of protein kinase A (PKA), protein kinase C (PKC) and, Ca2+/calmodulin-dependent protein kinase II (CaMKII), but not phosphoinositide 3-kinase(PI3K), by using the pharmacological the inhibitors: H-89, chelerythrine, KN-62, and LY294002, respectively totally abolished the cytoprotective effects of UA.	ursolic acid	309-311	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	111-117
31713091-8	2019	Finally, UA abrogated the reduction in phospho-extracellular signal-regulated kinases 1 and 2 (ERK1/2) but not in phospho-c-Jun kinases induced by corticosterone.	ursolic acid	9-11	mitogen-activated protein kinase 3	Mus musculus	95-101
31713091-9	2019	These results indicate that the protective effect of UA against the cytotoxicity induced by corticosterone in HT22 cells may involve PKA, PKC, CaMKII, and ERK1/2 activation.	ursolic acid	53-55	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	143-149
31713091-9	2019	These results indicate that the protective effect of UA against the cytotoxicity induced by corticosterone in HT22 cells may involve PKA, PKC, CaMKII, and ERK1/2 activation.	ursolic acid	53-55	mitogen-activated protein kinase 3	Mus musculus	155-161
31302461-0	2019	Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy.	ursolic acid	0-12	toll-like receptor 4	Mus musculus	65-69
31302461-0	2019	Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy.	ursolic acid	0-12	myeloid differentiation primary response gene 88	Mus musculus	70-75
31302461-10	2019	More importantly, enhanced autophagy of macrophages by UA through increasing the expression of both LC3B and Beclin-1 led to alter macrophage function.	ursolic acid	55-57	microtubule-associated protein 1 light chain 3 beta	Mus musculus	100-104
31302461-10	2019	More importantly, enhanced autophagy of macrophages by UA through increasing the expression of both LC3B and Beclin-1 led to alter macrophage function.	ursolic acid	55-57	beclin 1, autophagy related	Mus musculus	109-117
30703491-2	2019	AIM OF THE STUDY: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors.	ursolic acid	62-74	elastase, neutrophil expressed	Homo sapiens	135-154
31736766-4	2019	We investigated the effects of ursolic acid (UA), a traditional Chinese medicine with anti-fibrotic effects, on intestinal damage and bacterial disorder through the RhoA pathway.	ursolic acid	31-43	ras homolog family member A	Mus musculus	165-169
31736766-4	2019	We investigated the effects of ursolic acid (UA), a traditional Chinese medicine with anti-fibrotic effects, on intestinal damage and bacterial disorder through the RhoA pathway.	ursolic acid	45-47	ras homolog family member A	Mus musculus	165-169
31736766-5	2019	UA treatment reduced intestinal damage by inhibiting the inflammatory factor TNF-alpha and increasing the expression of tight junction proteins and antibacterial peptides to protect the intestinal barrier.	ursolic acid	0-2	tumor necrosis factor	Mus musculus	77-86
31736766-9	2019	Moreover, UA inhibited the expression of RhoA pathway components.	ursolic acid	10-12	ras homolog family member A	Mus musculus	41-45
31736766-10	2019	In conclusion, UA improves intestinal damage and bacterial dysbiosis partly via the RhoA pathway.	ursolic acid	15-17	ras homolog family member A	Mus musculus	84-88
30703491-2	2019	AIM OF THE STUDY: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors.	ursolic acid	76-78	elastase, neutrophil expressed	Homo sapiens	135-154
31237383-9	2019	Antioxidative stress master regulator Nrf2, cyclin D1, DNA damage, and anti-inflammatory pathways were induced by UA.	ursolic acid	114-116	cyclin D1	Mus musculus	44-53
31237383-9	2019	Antioxidative stress master regulator Nrf2, cyclin D1, DNA damage, and anti-inflammatory pathways were induced by UA.	ursolic acid	114-116	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-42
31237383-12	2019	Particularly, UA appears to drive Nrf2 and its upstream/downstream genes, anti-inflammatory (at early stages) and cell cycle regulatory (both early and late stages) genes, of which might contribute to the overall chemopreventive effects of UVB-induced MNSC.	ursolic acid	14-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
31356822-0	2019	Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.	ursolic acid	23-35	lon peptidase 1, mitochondrial	Homo sapiens	91-96
31356822-0	2019	Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.	ursolic acid	23-35	aconitase 2	Homo sapiens	97-101
31356822-0	2019	Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75.	ursolic acid	23-35	TNF receptor associated protein 1	Homo sapiens	102-107
31356822-3	2019	Although studies have reported that oxidative stress was involved in both the nephrotoxicity of OTA and the renoprotective function of UA, the role of stress-responsive Lon protease 1 (Lonp1) in the renoprotection of UA against OTA is still unknown.	ursolic acid	217-219	lon peptidase 1, mitochondrial	Homo sapiens	185-190
31356822-9	2019	In conclusion, OTA could inhibit the expression of Lonp1, suppressing Aco2 and Hsp75 as a result, thereby activating ROS and inducing cell death in HEK293T cells, which could be alleviated by UA pre-treatment.	ursolic acid	192-194	lon peptidase 1, mitochondrial	Homo sapiens	51-56
31611795-5	2019	Methods: We analyzed the effect of OA and UA on UGT1A expression and on the PXR/CAR regulatory pathway in HepG2 cells, hPXR-silenced HepG2 cells, and hCAR-silenced HepG2 cells by Q-PCR, Western blotting, and dual-luciferase reporter gene assays.	ursolic acid	42-44	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	48-53
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	ursolic acid	32-34	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	80-86
31611795-0	2019	Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.	ursolic acid	19-31	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	39-45
31611795-0	2019	Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.	ursolic acid	19-31	nuclear receptor subfamily 1 group I member 2	Homo sapiens	86-89
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	ursolic acid	32-34	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	88-94
31611795-0	2019	Oleanolic Acid and Ursolic Acid Induce UGT1A1 Expression in HepG2 Cells by Activating PXR Rather Than CAR.	ursolic acid	19-31	nuclear receptor subfamily 1 group I member 3	Homo sapiens	102-105
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	ursolic acid	32-34	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	96-102
31611795-2	2019	We previously demonstrated that UA can inhibit the activities of UGT1A3 and UGT1A4, and OA inhibits UGT1A3 activity in liver microsomes.	ursolic acid	32-34	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	65-71
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	ursolic acid	32-34	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	108-114
31611795-2	2019	We previously demonstrated that UA can inhibit the activities of UGT1A3 and UGT1A4, and OA inhibits UGT1A3 activity in liver microsomes.	ursolic acid	32-34	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	76-82
31611795-3	2019	However, whether OA and UA affect the expression of UGT1As in HepG2 cells and the underlying regulatory mechanism remain unclear.	ursolic acid	24-26	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	52-56
31611795-6	2019	Results: In HepG2 cells, OA and UA both significantly induced the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 and upregulated the expression of PXR.	ursolic acid	32-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	149-152
31611795-4	2019	Purpose: The present study aimed to explore the effect of OA and UA on the expression of UGT1As in HepG2 cells and the regulatory mechanisms on UGT1A1 based on the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) signaling pathways.	ursolic acid	65-67	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	89-93
31611795-8	2019	A dual-luciferase reporter assay showed that OA and UA could markedly promote PXR-mediated UGT1A1 luciferase activity, whereas OA and UA did not affect CAR-mediated UGT1A1 luciferase activity.	ursolic acid	52-54	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-81
31611795-8	2019	A dual-luciferase reporter assay showed that OA and UA could markedly promote PXR-mediated UGT1A1 luciferase activity, whereas OA and UA did not affect CAR-mediated UGT1A1 luciferase activity.	ursolic acid	52-54	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	91-97
31611795-10	2019	However, the expression of UGT1A1 in hCAR-silenced HepG2 cells was markedly elevated compared to the control group or with non-silenced HepG2 cells treated with OA (10, 20, and 40 muM) or UA (10, 20, and 40 muM).	ursolic acid	188-190	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	27-33
31611795-10	2019	However, the expression of UGT1A1 in hCAR-silenced HepG2 cells was markedly elevated compared to the control group or with non-silenced HepG2 cells treated with OA (10, 20, and 40 muM) or UA (10, 20, and 40 muM).	ursolic acid	188-190	CXADR Ig-like cell adhesion molecule	Homo sapiens	37-41
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	62-68
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	70-76
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	78-84
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	90-96
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	136-142
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	nuclear receptor subfamily 1 group I member 2	Homo sapiens	158-161
31611795-11	2019	Conclusions: OA and UA significantly induce the expression of UGT1A1, UGT1A3, UGT1A4, and UGT1A9 in HepG2 cells, and their induction on UGT1A1 is mediated by PXR activation, not CAR.	ursolic acid	20-22	nuclear receptor subfamily 1 group I member 3	Homo sapiens	178-181
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	forkhead box M1	Homo sapiens	294-299
31547522-5	2019	Ursolic acid activates AKT/mTOR pathways and oleanolic acid triggers a pathway independent on AKT.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	23-26
31547522-5	2019	Ursolic acid activates AKT/mTOR pathways and oleanolic acid triggers a pathway independent on AKT.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	27-31
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	KRAS proto-oncogene, GTPase	Homo sapiens	301-305
31547522-7	2019	The PINK1/Parkin axis is a pathway usually associated with mitophagy, however, the mitophagy induced by ursolic or oleanolic acid is just dependent on PINK1.	ursolic acid	104-111	PTEN induced kinase 1	Homo sapiens	4-9
31547522-7	2019	The PINK1/Parkin axis is a pathway usually associated with mitophagy, however, the mitophagy induced by ursolic or oleanolic acid is just dependent on PINK1.	ursolic acid	104-111	PTEN induced kinase 1	Homo sapiens	151-156
31547587-0	2019	Activating Hippo Pathway via Rassf1 by Ursolic Acid Suppresses the Tumorigenesis of Gastric Cancer.	ursolic acid	39-51	Ras association domain family member 1	Homo sapiens	29-35
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	Ras association domain family member 1	Homo sapiens	131-137
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	macrophage stimulating 1	Homo sapiens	173-177
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	serine/threonine kinase 3	Homo sapiens	179-183
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	large tumor suppressor kinase 1	Homo sapiens	189-194
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	basic leucine zipper ATF-like transcription factor	Homo sapiens	311-315
31547587-8	2019	Gene ontology analysis revealed that several genes, such as the Hippo pathway upstream target gene, ras association domain family (RASSF1), and its downstream target genes (MST1, MST2, and LATS1) were significantly upregulated by UA, while the expression of YAP1 gene, together with oncogenes (FOXM1, KRAS, and BATF), were significantly decreased.	ursolic acid	230-232	Yes1 associated transcriptional regulator	Homo sapiens	258-262
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	Ras association domain family member 1	Homo sapiens	72-78
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	macrophage stimulating 1	Homo sapiens	80-84
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	serine/threonine kinase 3	Homo sapiens	86-90
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	large tumor suppressor kinase 1	Homo sapiens	92-97
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	Yes1 associated transcriptional regulator	Homo sapiens	105-108
31547587-9	2019	Similar to the gene expression profiling results, the protein levels of RASSF1, MST1, MST2, LATS1, and p-YAP were increased, whereas those of CTGF were decreased by UA in gastric cancer cells.	ursolic acid	165-167	cellular communication network factor 2	Homo sapiens	142-146
31547587-10	2019	The p-YAP expression induced in gastric cancer cells by UA was reversed with RASSF1 silencing.	ursolic acid	56-58	Yes1 associated transcriptional regulator	Homo sapiens	6-9
31547587-10	2019	The p-YAP expression induced in gastric cancer cells by UA was reversed with RASSF1 silencing.	ursolic acid	56-58	Ras association domain family member 1	Homo sapiens	77-83
31547587-12	2019	Collectively, UA diminishes the proliferation and metastasis of gastric cancer via the regulation of Hippo pathway through Rassf1, which suggests that UA can be used as a potential chemopreventive and therapeutic agent for gastric cancer.	ursolic acid	14-16	Ras association domain family member 1	Homo sapiens	123-129
31547587-12	2019	Collectively, UA diminishes the proliferation and metastasis of gastric cancer via the regulation of Hippo pathway through Rassf1, which suggests that UA can be used as a potential chemopreventive and therapeutic agent for gastric cancer.	ursolic acid	151-153	Ras association domain family member 1	Homo sapiens	123-129
31452805-0	2019	Ursolic acid suppresses the invasive potential of colorectal cancer cells by regulating the TGF-beta1/ZEB1/miR-200c signaling pathway.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	92-101
31062913-4	2019	UA induced caspase-dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF-kappaB signaling, ERK, and p38.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	129-132
31062913-4	2019	UA induced caspase-dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF-kappaB signaling, ERK, and p38.	ursolic acid	0-2	mechanistic target of rapamycin kinase	Homo sapiens	133-137
31062913-4	2019	UA induced caspase-dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF-kappaB signaling, ERK, and p38.	ursolic acid	0-2	mitogen-activated protein kinase 1	Homo sapiens	159-162
31062913-4	2019	UA induced caspase-dependent apoptosis accompanied with the modulation of various biological biomarkers including downregulating Akt/mTOR/NF-kappaB signaling, ERK, and p38.	ursolic acid	0-2	mitogen-activated protein kinase 14	Homo sapiens	168-171
31062913-5	2019	In addition, UA inhibited angiogenesis as evidenced by abrogation of migration/invasion and blocking MMP-2 secretion in Ca922 cells.	ursolic acid	13-15	matrix metallopeptidase 2	Homo sapiens	101-106
31062913-6	2019	Interestingly, UA induced autophagy in OSCC cells, as manifested by LC3B-II conversion and increased p62 expression and accumulation of autophagosomes.	ursolic acid	15-17	nucleoporin 62	Homo sapiens	101-104
31404298-5	2019	Western blot analysis and reverse transcription-quantitative polymerase chain reaction were used to detect the effects of different concentrations of ursolic acid on EGFR signaling pathway-related proteins, cell cycle, apoptosis and cell migration-related proteins.	ursolic acid	150-162	epidermal growth factor receptor	Homo sapiens	166-170
31404298-6	2019	After overexpression or silencing of EGFR, the effects of ursolic acid on EGFR pathway and cell biological function were subsequently detected, using the same methods.	ursolic acid	58-70	epidermal growth factor receptor	Homo sapiens	74-78
31404298-7	2019	The present study identified that ursolic acid had inhibitory effects on the growth and metastatic ability of osteosarcoma cells by suppressing EGFR.	ursolic acid	34-46	epidermal growth factor receptor	Homo sapiens	144-148
31545303-0	2019	Inhibition of Proliferation of SGC7901 and BGC823 Human Gastric Cancer Cells by Ursolic Acid Occurs Through a Caspase-Dependent Apoptotic Pathway.	ursolic acid	80-92	caspase 8	Homo sapiens	110-117
31545303-11	2019	Ursolic acid treatment significantly induced apoptosis in SGC7901 and BGC823 cells when compared with GES-1 cells (P<0.05), and significantly increased the activation of caspase-3, caspase-8, caspase-9, poly ADPribose polymerase (PARP), and the production of reactive oxygen species (ROS).	ursolic acid	0-12	caspase 3	Homo sapiens	170-179
31545303-11	2019	Ursolic acid treatment significantly induced apoptosis in SGC7901 and BGC823 cells when compared with GES-1 cells (P<0.05), and significantly increased the activation of caspase-3, caspase-8, caspase-9, poly ADPribose polymerase (PARP), and the production of reactive oxygen species (ROS).	ursolic acid	0-12	caspase 8	Homo sapiens	181-190
31545303-11	2019	Ursolic acid treatment significantly induced apoptosis in SGC7901 and BGC823 cells when compared with GES-1 cells (P<0.05), and significantly increased the activation of caspase-3, caspase-8, caspase-9, poly ADPribose polymerase (PARP), and the production of reactive oxygen species (ROS).	ursolic acid	0-12	caspase 9	Homo sapiens	192-201
31545303-11	2019	Ursolic acid treatment significantly induced apoptosis in SGC7901 and BGC823 cells when compared with GES-1 cells (P<0.05), and significantly increased the activation of caspase-3, caspase-8, caspase-9, poly ADPribose polymerase (PARP), and the production of reactive oxygen species (ROS).	ursolic acid	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	230-234
31545303-13	2019	<strong>CONCLUSIONS</strong> Ursolic acid inhibited the proliferation of SGC7901 and BGC823 human gastric cancer cells <i>in vitro</i> through a caspase-dependent apoptotic pathway.	ursolic acid	29-41	caspase 8	Homo sapiens	145-152
31452805-0	2019	Ursolic acid suppresses the invasive potential of colorectal cancer cells by regulating the TGF-beta1/ZEB1/miR-200c signaling pathway.	ursolic acid	0-12	zinc finger E-box binding homeobox 1	Homo sapiens	102-106
31452805-0	2019	Ursolic acid suppresses the invasive potential of colorectal cancer cells by regulating the TGF-beta1/ZEB1/miR-200c signaling pathway.	ursolic acid	0-12	microRNA 200c	Homo sapiens	107-115
31452805-6	2019	In addition, to evaluate whether the anticancer properties of UA were mediated by the regulation of a double-negative feedback loop consisting of the transforming growth factor-beta1 (TGF-beta1)/zinc finger E-box-binding homeobox (ZEB1) pathway and microRNA (miR)-200a/b/c, reverse transcription-quantitative PCR and western blot analysis were performed.	ursolic acid	62-64	transforming growth factor beta 1	Homo sapiens	150-182
31452805-6	2019	In addition, to evaluate whether the anticancer properties of UA were mediated by the regulation of a double-negative feedback loop consisting of the transforming growth factor-beta1 (TGF-beta1)/zinc finger E-box-binding homeobox (ZEB1) pathway and microRNA (miR)-200a/b/c, reverse transcription-quantitative PCR and western blot analysis were performed.	ursolic acid	62-64	transforming growth factor beta 1	Homo sapiens	184-193
31452805-8	2019	Furthermore, following UA treatment, several crucial mediators of the TGF-beta1 signaling pathway, including TGF-beta1, phosphorylated (p)-Smad2/3, p-focal adhesion kinase and ZEB1, were significantly downregulated in the HCT116 and HCT-8 cell lines compared with the control group.	ursolic acid	23-25	transforming growth factor beta 1	Homo sapiens	70-79
31452805-8	2019	Furthermore, following UA treatment, several crucial mediators of the TGF-beta1 signaling pathway, including TGF-beta1, phosphorylated (p)-Smad2/3, p-focal adhesion kinase and ZEB1, were significantly downregulated in the HCT116 and HCT-8 cell lines compared with the control group.	ursolic acid	23-25	transforming growth factor beta 1	Homo sapiens	109-118
31452805-8	2019	Furthermore, following UA treatment, several crucial mediators of the TGF-beta1 signaling pathway, including TGF-beta1, phosphorylated (p)-Smad2/3, p-focal adhesion kinase and ZEB1, were significantly downregulated in the HCT116 and HCT-8 cell lines compared with the control group.	ursolic acid	23-25	SMAD family member 2	Homo sapiens	139-146
31452805-8	2019	Furthermore, following UA treatment, several crucial mediators of the TGF-beta1 signaling pathway, including TGF-beta1, phosphorylated (p)-Smad2/3, p-focal adhesion kinase and ZEB1, were significantly downregulated in the HCT116 and HCT-8 cell lines compared with the control group.	ursolic acid	23-25	zinc finger E-box binding homeobox 1	Homo sapiens	176-180
31452805-10	2019	Finally, UA significantly upregulated miR200a/b/c, with miR-200c exhibiting the highest increase in expression levels following UA treatment.	ursolic acid	9-11	microRNA 200a	Homo sapiens	38-45
31452805-10	2019	Finally, UA significantly upregulated miR200a/b/c, with miR-200c exhibiting the highest increase in expression levels following UA treatment.	ursolic acid	128-130	microRNA 200c	Homo sapiens	56-64
31452805-11	2019	Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.	ursolic acid	82-84	transforming growth factor beta 1	Homo sapiens	116-125
31452805-11	2019	Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.	ursolic acid	82-84	zinc finger E-box binding homeobox 1	Homo sapiens	126-130
31452805-11	2019	Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.	ursolic acid	82-84	microRNA 200c	Homo sapiens	131-139
31452805-11	2019	Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.	ursolic acid	203-205	transforming growth factor beta 1	Homo sapiens	116-125
31452805-11	2019	Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.	ursolic acid	203-205	zinc finger E-box binding homeobox 1	Homo sapiens	126-130
31452805-11	2019	Collectively, the present study suggested that inhibition of CRC cell invasion by UA occurred via regulation of the TGF-beta1/ZEB1/miR-200c signaling network, which may be one of the mechanisms by which UA appears to be an effective therapeutic agent against colon cancer.	ursolic acid	203-205	microRNA 200c	Homo sapiens	131-139
31423212-11	2019	In summary, UA induces the apoptosis and inhibits the invasion of GBC-SD cells, which may be associated with the suppression of NF-kappaB and Akt signaling pathways.	ursolic acid	12-14	AKT serine/threonine kinase 1	Homo sapiens	142-145
31497225-5	2019	In addition, FAS inhibitors, such as curcumin, ursolic acid, and resveratrol, have shown anti-cancer potential.	ursolic acid	47-59	fatty acid synthase	Homo sapiens	13-16
31443577-0	2019	Ursolic Acid Derivatives as Potential Agents Against Acanthamoeba Spp.	ursolic acid	0-12	histocompatibility minor 13	Homo sapiens	66-69
31460269-4	2019	Rubrofusarin showed potent inhibition against the PTP1B enzyme (IC50; 16.95 +- 0.49 muM), and its glycosides reduced activity (IC50; 87.36 +- 1.08 muM for 1 and &gt;100 muM for 2-4) than did the reference drug, ursolic acid (IC50; 2.29 +- 0.04 muM).	ursolic acid	211-223	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	50-55
31417419-4	2019	The goal of this study was to investigate the effects of UA on the intestinal mucosal barrier in CCl4-induced hepatic fibrosis in rats and identify its associated mechanisms.	ursolic acid	57-59	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
31417419-7	2019	The results demonstrated that UA attenuated the following: (i) liver and intestinal pathological injury; (ii) cleaved caspase-3 expression in the ileal epithelial cells; (iii) serum lipopolysaccharide and procalcitonin levels; (iv) intestinal malondialdehyde levels; and (v) the expression of the NOX protein components NOX2 and P67phox in ileal tissues.	ursolic acid	30-32	cytochrome b-245 beta chain	Rattus norvegicus	320-324
31417419-8	2019	Furthermore, our results suggested that UA improved intestinal dysbiosis and the expression of the tight junction proteins Claudin 1 and Occludin in the ileum of rats.	ursolic acid	40-42	claudin 1	Rattus norvegicus	123-132
31417419-8	2019	Furthermore, our results suggested that UA improved intestinal dysbiosis and the expression of the tight junction proteins Claudin 1 and Occludin in the ileum of rats.	ursolic acid	40-42	occludin	Rattus norvegicus	137-145
31417419-9	2019	These results indicate that UA has protective effects on the intestinal mucosal barrier in rats with CCl4-induced liver fibrosis by inhibiting intestinal NOX-mediated oxidative stress.	ursolic acid	28-30	C-C motif chemokine ligand 4	Rattus norvegicus	101-105
31333459-6	2019	The results indicated that peiminine (PEI) target epidermal growth factor receptor (EGFR) prevented the exacerbation of COPD by inhibiting the EGFR signaling pathway, and ursolic acid (UA) can alleviate inflammation disorders via inhibition of CASP3 on mitogen-activated protein kinase (MAPK) signaling pathway.	ursolic acid	171-183	caspase 3	Mus musculus	244-249
30538052-5	2019	Experimental tracing of the dynamics of penetration and distribution of the labeled ursolic acid has shown that when the acid enters the cell, it initially localizes on the inner membranes where the predicted target Akt1/protein kinase B - a protein that inhibits apoptosis - is located.	ursolic acid	84-96	AKT serine/threonine kinase 1	Homo sapiens	216-220
30977399-6	2019	Furthermore, expression of MMP-2, MMP-9, collagen type I, alpha-SMA, and TGF-beta downregulated in UA-administered rats.	ursolic acid	99-101	matrix metallopeptidase 2	Rattus norvegicus	27-32
30977399-6	2019	Furthermore, expression of MMP-2, MMP-9, collagen type I, alpha-SMA, and TGF-beta downregulated in UA-administered rats.	ursolic acid	99-101	matrix metallopeptidase 9	Rattus norvegicus	34-39
30977399-6	2019	Furthermore, expression of MMP-2, MMP-9, collagen type I, alpha-SMA, and TGF-beta downregulated in UA-administered rats.	ursolic acid	99-101	actin gamma 2, smooth muscle	Rattus norvegicus	58-67
31281258-1	2019	Background: We found previously that ursolic acid (UA) administration could alleviate cigarette smoke-induced emphysema in rats partly through the unfolded protein response (UPR) PERK-CHOP and Nrf2 pathways, thus alleviating endoplasmic reticulum stress (ERS)-associated oxidative stress and cell apoptosis.	ursolic acid	37-49	DNA-damage inducible transcript 3	Rattus norvegicus	184-188
31281258-1	2019	Background: We found previously that ursolic acid (UA) administration could alleviate cigarette smoke-induced emphysema in rats partly through the unfolded protein response (UPR) PERK-CHOP and Nrf2 pathways, thus alleviating endoplasmic reticulum stress (ERS)-associated oxidative stress and cell apoptosis.	ursolic acid	37-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	193-197
31281258-1	2019	Background: We found previously that ursolic acid (UA) administration could alleviate cigarette smoke-induced emphysema in rats partly through the unfolded protein response (UPR) PERK-CHOP and Nrf2 pathways, thus alleviating endoplasmic reticulum stress (ERS)-associated oxidative stress and cell apoptosis.	ursolic acid	51-53	DNA-damage inducible transcript 3	Rattus norvegicus	184-188
31281258-1	2019	Background: We found previously that ursolic acid (UA) administration could alleviate cigarette smoke-induced emphysema in rats partly through the unfolded protein response (UPR) PERK-CHOP and Nrf2 pathways, thus alleviating endoplasmic reticulum stress (ERS)-associated oxidative stress and cell apoptosis.	ursolic acid	51-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	193-197
31281258-9	2019	UA exerted its effects through ameliorating apoptosis by down regulating UPR signalling pathways and subsequent apoptosis pathways, as well as, downregulating p-Smad2 and p-Smad3 molecules.	ursolic acid	0-2	SMAD family member 2	Rattus norvegicus	161-166
31281258-9	2019	UA exerted its effects through ameliorating apoptosis by down regulating UPR signalling pathways and subsequent apoptosis pathways, as well as, downregulating p-Smad2 and p-Smad3 molecules.	ursolic acid	0-2	SMAD family member 3	Rattus norvegicus	173-178
31281258-10	2019	Conclusions: UA attenuated CSE-induced emphysema and airway remodeling, exerting its effects partly through regulation of three UPR pathways, amelioration downstream apoptotic pathways, and alleviating activation of Smad2 and Smad3.	ursolic acid	13-15	SMAD family member 2	Rattus norvegicus	216-221
31281258-10	2019	Conclusions: UA attenuated CSE-induced emphysema and airway remodeling, exerting its effects partly through regulation of three UPR pathways, amelioration downstream apoptotic pathways, and alleviating activation of Smad2 and Smad3.	ursolic acid	13-15	SMAD family member 3	Rattus norvegicus	226-231
31006525-3	2019	Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-1alpha transcriptional inhibitors.	ursolic acid	37-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
31006525-3	2019	Here, we designed and synthesized 31 ursolic acid (UA) derivatives containing a tetrazole moiety and evaluated them for their potential anti-tumor activities as HIF-1alpha transcriptional inhibitors.	ursolic acid	51-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
31259152-11	2019	UA treatment significantly increased the expression of miR-149-5p, which was lower in 231/PTX cells than in 231 cells.	ursolic acid	0-2	microRNA 149	Mus musculus	55-62
31259152-12	2019	Furthermore, the overexpression of miR-149-5p increased the sensitivity of 231/PTX cells to PTX treatment, whereas the knockdown of the miR-149-5p gene attenuated the effects of UA on the regulation of PTX sensitivity.	ursolic acid	178-180	microRNA 149	Mus musculus	136-143
31259152-14	2019	Meanwhile, the downregulation of MyD88 through the overexpression of miR-149-5p or UA treatment inhibited the activation of the Akt signaling pathway in 231/PTX cells.	ursolic acid	83-85	myeloid differentiation primary response gene 88	Mus musculus	33-38
31259152-15	2019	Thus, our data indicate that UA can reverse PTX resistance by targeting the miRNA-149-5p/MyD88 axis in breast cancer cells.	ursolic acid	29-31	myeloid differentiation primary response gene 88	Mus musculus	89-94
31281396-0	2019	Ursolic Acid Inhibits Epithelial-Mesenchymal Transition through the Axl/NF-kappaB Pathway in Gastric Cancer Cells.	ursolic acid	0-12	AXL receptor tyrosine kinase	Homo sapiens	68-71
31281396-0	2019	Ursolic Acid Inhibits Epithelial-Mesenchymal Transition through the Axl/NF-kappaB Pathway in Gastric Cancer Cells.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	72-81
31281396-9	2019	(3) UA significantly decreased the expressions of N-Cadherin, Vimentin, Snail, Twist p-Axl, p-IKKalpha/beta, and p-NF-kappaB in BGC-823 and MGC-803 cells.	ursolic acid	4-6	cadherin 2	Homo sapiens	50-60
31281396-9	2019	(3) UA significantly decreased the expressions of N-Cadherin, Vimentin, Snail, Twist p-Axl, p-IKKalpha/beta, and p-NF-kappaB in BGC-823 and MGC-803 cells.	ursolic acid	4-6	vimentin	Homo sapiens	62-70
31281396-9	2019	(3) UA significantly decreased the expressions of N-Cadherin, Vimentin, Snail, Twist p-Axl, p-IKKalpha/beta, and p-NF-kappaB in BGC-823 and MGC-803 cells.	ursolic acid	4-6	snail family transcriptional repressor 1	Homo sapiens	72-77
31281396-9	2019	(3) UA significantly decreased the expressions of N-Cadherin, Vimentin, Snail, Twist p-Axl, p-IKKalpha/beta, and p-NF-kappaB in BGC-823 and MGC-803 cells.	ursolic acid	4-6	AXL receptor tyrosine kinase	Homo sapiens	87-90
31281396-9	2019	(3) UA significantly decreased the expressions of N-Cadherin, Vimentin, Snail, Twist p-Axl, p-IKKalpha/beta, and p-NF-kappaB in BGC-823 and MGC-803 cells.	ursolic acid	4-6	nuclear factor kappa B subunit 1	Homo sapiens	115-124
31281396-10	2019	(4) UA distinctly decreased the expressions of N-Cadherin, Snail, p-Axl, and p-IKKalpha/beta in gastric cancer xenograft model rats.	ursolic acid	4-6	cadherin 2	Homo sapiens	47-57
31281396-10	2019	(4) UA distinctly decreased the expressions of N-Cadherin, Snail, p-Axl, and p-IKKalpha/beta in gastric cancer xenograft model rats.	ursolic acid	4-6	snail family transcriptional repressor 1	Homo sapiens	59-64
31281396-10	2019	(4) UA distinctly decreased the expressions of N-Cadherin, Snail, p-Axl, and p-IKKalpha/beta in gastric cancer xenograft model rats.	ursolic acid	4-6	AXL receptor tyrosine kinase	Homo sapiens	68-71
30977399-0	2019	Ursolic acid modulates MMPs, collagen-I, alpha-SMA, and TGF-beta expression in isoproterenol-induced myocardial infarction in rats.	ursolic acid	0-12	matrix metallopeptidase 2	Rattus norvegicus	23-27
30977399-0	2019	Ursolic acid modulates MMPs, collagen-I, alpha-SMA, and TGF-beta expression in isoproterenol-induced myocardial infarction in rats.	ursolic acid	0-12	actin gamma 2, smooth muscle	Rattus norvegicus	41-50
31259152-0	2019	Ursolic Acid Reverses the Chemoresistance of Breast Cancer Cells to Paclitaxel by Targeting MiRNA-149-5p/MyD88.	ursolic acid	0-12	myeloid differentiation primary response gene 88	Mus musculus	105-110
30538052-5	2019	Experimental tracing of the dynamics of penetration and distribution of the labeled ursolic acid has shown that when the acid enters the cell, it initially localizes on the inner membranes where the predicted target Akt1/protein kinase B - a protein that inhibits apoptosis - is located.	ursolic acid	84-96	protein tyrosine kinase 2 beta	Homo sapiens	221-237
30419364-4	2019	The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances.	ursolic acid	104-106	citrate synthase	Homo sapiens	126-128
30419364-4	2019	The mesoporous structure within the MBG microspheres and the hydrogen bonding between the scaffolds and UA drugs made the MBG/CS/UA scaffolds have controlled drug release performances.	ursolic acid	129-131	citrate synthase	Homo sapiens	126-128
30419364-6	2019	Moreover, the results of micro-CT images, histomorphological observations demonstrated that the MBG/CS/UA scaffolds improved new bone formation ability.	ursolic acid	103-105	citrate synthase	Homo sapiens	100-102
31083310-7	2019	LPS upregulated gene expressions of NF-kappaB subunits and of ICAM-1, TNF-alpha, iNOS, and COX-2 within 8 h, which could be decreased by 18beta glycyrrhetinic acid, isoliquiritigenin and ursolic acid similarly to the anti-inflammatory drug dexamethasone.	ursolic acid	187-199	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	36-45
30920308-9	2019	In conclusion, UA is an effective oral GLP-2 secretagogue in parenterally fed pigs but is not capable of augmenting GLP-2 secretion or the intestinal adaptation response after massive small bowel resection.	ursolic acid	15-17	glucagon	Homo sapiens	39-44
31083310-8	2019	NF-kappaB translocation from cytoplasm to nucleus was observed after LPS stimulation for 2 h and was attenuated by extracts of Glycyrrhiza glabra and Eriobotrya japonica, as well as by 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid.	ursolic acid	236-248	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-9
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	intercellular adhesion molecule 1	Mus musculus	111-117
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	tumor necrosis factor	Mus musculus	119-128
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	cytochrome c oxidase II, mitochondrial	Mus musculus	130-135
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	nitric oxide synthase 2, inducible	Mus musculus	141-145
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	173-182
31083310-9	2019	Conclusions: 18beta glycyrrhetinic acid, isoliquiritigenin, and ursolic acid inhibited the gene expressions of ICAM-1, TNF-alpha, COX-2, and iNOS, partly through inhibiting NF-kappaB expression and attenuating NF-kappaB nuclear translocation.	ursolic acid	64-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	210-219
28911340-0	2019	Ursolic Acid Attenuates TGF-beta1-Induced Epithelial-Mesenchymal Transition in NSCLC by Targeting Integrin alphaVbeta5/MMPs Signaling.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	24-33
28911340-0	2019	Ursolic Acid Attenuates TGF-beta1-Induced Epithelial-Mesenchymal Transition in NSCLC by Targeting Integrin alphaVbeta5/MMPs Signaling.	ursolic acid	0-12	matrix metallopeptidase 2	Homo sapiens	119-123
28911340-4	2019	However, whether ursolic acid can attenuate TGF-beta1-induced EMT in H1975 cells and its underlying mechanisms remain unknown.	ursolic acid	17-29	transforming growth factor beta 1	Homo sapiens	44-53
28911340-5	2019	In this study, ursolic acid significantly attenuated the TGF-beta1-induced decrease in E-cadherin level and elevated the level of N-cadherin.	ursolic acid	15-27	transforming growth factor beta 1	Homo sapiens	57-66
28911340-5	2019	In this study, ursolic acid significantly attenuated the TGF-beta1-induced decrease in E-cadherin level and elevated the level of N-cadherin.	ursolic acid	15-27	cadherin 1	Homo sapiens	87-97
28911340-5	2019	In this study, ursolic acid significantly attenuated the TGF-beta1-induced decrease in E-cadherin level and elevated the level of N-cadherin.	ursolic acid	15-27	cadherin 2	Homo sapiens	130-140
28911340-6	2019	Furthermore, ursolic acid inhibited the mesenchymal-like responses in H1975 cells, including cell migration, invasion, and activity of matrix metallopeptidase (MMP)-2 and -9.	ursolic acid	13-25	matrix metallopeptidase 2	Homo sapiens	135-173
28911340-7	2019	Finally, our new findings provided evidence that ursolic acid could inhibit EMT in NSCLC through TGF-beta1 signaling pathway-mediated integrin alphaVbeta5 expression, and this might be the potential mechanism of resveratrol on the inhibition of invasion and metastases in NSCLC.	ursolic acid	49-61	transforming growth factor beta 1	Homo sapiens	97-106
28911340-8	2019	We conclude that ursolic acid attenuated TGF-beta1-induced EMT in H1975 cells and thus might be a promising therapeutic agent for treating NSCLC.	ursolic acid	17-29	transforming growth factor beta 1	Homo sapiens	41-50
31130857-0	2019	Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells.	ursolic acid	111-123	NADPH oxidase 4	Rattus norvegicus	35-39
31130857-0	2019	Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells.	ursolic acid	111-123	ras homolog family member A	Rattus norvegicus	48-52
31130857-0	2019	Interaction Mechanisms Between the NOX4/ROS and RhoA/ROCK1 Signaling Pathways as New Anti- fibrosis Targets of Ursolic Acid in Hepatic Stellate Cells.	ursolic acid	111-123	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	53-58
30467864-5	2019	KEY FINDINGS: The active substances betulinic acid (BA) and ursolic acid (UA) strongly inhibited CYP3A4 activity while UA and lupeol moderately inhibited CYP2C19.	ursolic acid	60-72	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	97-103
30976816-0	2019	Ursolic acid downregulates thymic stromal lymphopoietin through the blockade of intracellular calcium/caspase-1/NF-kappaB signaling cascade in HMC-1 cells.	ursolic acid	0-12	thymic stromal lymphopoietin	Homo sapiens	27-55
30976816-0	2019	Ursolic acid downregulates thymic stromal lymphopoietin through the blockade of intracellular calcium/caspase-1/NF-kappaB signaling cascade in HMC-1 cells.	ursolic acid	0-12	caspase 1	Homo sapiens	102-111
30976816-0	2019	Ursolic acid downregulates thymic stromal lymphopoietin through the blockade of intracellular calcium/caspase-1/NF-kappaB signaling cascade in HMC-1 cells.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	112-121
30976816-3	2019	However, the effect of UA on TSLP regulation has not been fully elucidated.	ursolic acid	23-25	thymic stromal lymphopoietin	Homo sapiens	29-33
30976816-4	2019	The aim of the present study was to analyze how UA regulates the production of TSLP in the human mast cell line HMC-1.	ursolic acid	48-50	thymic stromal lymphopoietin	Homo sapiens	79-83
31151763-0	2019	Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-beta1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene.	ursolic acid	22-34	transforming growth factor beta 1	Homo sapiens	65-74
31151763-0	2019	Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-beta1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene.	ursolic acid	22-34	AKT serine/threonine kinase 1	Homo sapiens	134-137
31151763-0	2019	Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-beta1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene.	ursolic acid	22-34	mechanistic target of rapamycin kinase	Homo sapiens	138-142
31151763-0	2019	Inhibitory effects of ursolic acid from Bushen Yijing Formula on TGF-beta1-induced human umbilical vein endothelial cell fibrosis via AKT/mTOR signaling and Snail gene.	ursolic acid	22-34	snail family transcriptional repressor 1	Homo sapiens	157-162
31151763-5	2019	Ursolic acid and drug-contained serum ameliorated EndMT biomarker gene expression changes and angiogenesis capacity suppression induced by TGF-beta treatment.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	139-147
31151763-6	2019	Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum.	ursolic acid	156-168	snail family transcriptional repressor 2	Homo sapiens	0-4
31151763-6	2019	Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum.	ursolic acid	156-168	snail family transcriptional repressor 1	Homo sapiens	6-11
31151763-6	2019	Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum.	ursolic acid	156-168	mechanistic target of rapamycin kinase	Homo sapiens	62-91
31151763-6	2019	Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum.	ursolic acid	156-168	mechanistic target of rapamycin kinase	Homo sapiens	93-97
31151763-6	2019	Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum.	ursolic acid	156-168	AKT serine/threonine kinase 1	Homo sapiens	103-106
31151763-6	2019	Slug, Snail, and Twist gene expression and phosphorylation of mammalian target of rapamycin (mTOR) and AKT altered by TGF-beta in HUVECs were suppressed by ursolic acid and drug-contained serum.	ursolic acid	156-168	transforming growth factor beta 1	Homo sapiens	118-126
31151763-8	2019	Overexpression of Snail gene promoted expression of EndMT-related genes and suppressed angiogenesis in HUVECs, which were attenuated by application of ursolic acid and drug-contained serum.	ursolic acid	151-163	snail family transcriptional repressor 1	Homo sapiens	18-23
31151763-9	2019	Ursolic acid from Bushen Yijing Formula inhibits human umbilical vein endothelial cell EndMT and fibrosis, mediated by AKT/mTOR signaling and Snail gene expression.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	119-122
31151763-9	2019	Ursolic acid from Bushen Yijing Formula inhibits human umbilical vein endothelial cell EndMT and fibrosis, mediated by AKT/mTOR signaling and Snail gene expression.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	123-127
31151763-9	2019	Ursolic acid from Bushen Yijing Formula inhibits human umbilical vein endothelial cell EndMT and fibrosis, mediated by AKT/mTOR signaling and Snail gene expression.	ursolic acid	0-12	snail family transcriptional repressor 1	Homo sapiens	142-147
30728113-0	2019	Design, synthesis, and screening of novel ursolic acid derivatives as potential anti-cancer agents that target the HIF-1alpha pathway.	ursolic acid	42-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
30728113-2	2019	Here, we designed and synthesized three novel series of ursolic acid derivatives containing an aminoguanidine moiety and evaluated them as HIF-1alpha inhibitors and anti-cancer agents using human cancer cell lines.	ursolic acid	56-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	139-149
30804116-0	2019	Ursolic Acid Induces Apoptotic Cell Death Through AIF and Endo G Release Through a Mitochondria-dependent Pathway in NCI-H292 Human Lung Cancer Cells In Vitro.	ursolic acid	0-12	apoptosis inducing factor mitochondria associated 1	Homo sapiens	50-53
30804116-0	2019	Ursolic Acid Induces Apoptotic Cell Death Through AIF and Endo G Release Through a Mitochondria-dependent Pathway in NCI-H292 Human Lung Cancer Cells In Vitro.	ursolic acid	0-12	endonuclease G	Homo sapiens	58-64
30804116-9	2019	CONCLUSION: Based on these observations, we suggest UA induces apoptotic cell death via AIF and Endo G release through a mitochondria-dependent pathway in NCI-H292 cells.	ursolic acid	52-54	apoptosis inducing factor mitochondria associated 1	Homo sapiens	88-91
30804116-9	2019	CONCLUSION: Based on these observations, we suggest UA induces apoptotic cell death via AIF and Endo G release through a mitochondria-dependent pathway in NCI-H292 cells.	ursolic acid	52-54	endonuclease G	Homo sapiens	96-102
30976816-6	2019	The results revealed that UA inhibited TSLP production and mRNA expression.	ursolic acid	26-28	thymic stromal lymphopoietin	Homo sapiens	39-43
30976816-8	2019	Caspase-1 activity was increased by exposure to phorbol myristate acetate plus calcium ionophore, whereas it was reduced by UA.	ursolic acid	124-126	caspase 1	Homo sapiens	0-9
30976816-10	2019	These results indicated that UA may be a useful agent for the treatment and/or prevention of atopic and inflammatory diseases, and its effects are likely mediated by TSLP downregulation.	ursolic acid	29-31	thymic stromal lymphopoietin	Homo sapiens	166-170
30609217-0	2019	Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling.	ursolic acid	0-12	nitric oxide synthase 3, endothelial cell	Mus musculus	75-79
30609217-0	2019	Ursolic acid prevents doxorubicin-induced cardiac toxicity in mice through eNOS activation and inhibition of eNOS uncoupling.	ursolic acid	0-12	nitric oxide synthase 3, endothelial cell	Mus musculus	109-113
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	thymoma viral proto-oncogene 1	Mus musculus	40-43
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	nitric oxide synthase 3, endothelial cell	Mus musculus	48-81
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	nitric oxide synthase 3, endothelial cell	Mus musculus	83-87
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	nitric oxide synthase 3, endothelial cell	Mus musculus	126-130
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	nitric oxide synthase 3, endothelial cell	Mus musculus	126-130
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	NADPH oxidase 4	Mus musculus	204-219
30609217-4	2019	Mechanistically, ursolic acid increased AKT and endothelial nitric-oxide synthase (eNOS) phosphorylation levels, and enhanced eNOS expression, while inhibiting doxorubicin induced eNOS uncoupling through NADPH oxidase 4 (NOX4) down-regulation.	ursolic acid	17-29	NADPH oxidase 4	Mus musculus	221-225
30467864-5	2019	KEY FINDINGS: The active substances betulinic acid (BA) and ursolic acid (UA) strongly inhibited CYP3A4 activity while UA and lupeol moderately inhibited CYP2C19.	ursolic acid	74-76	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	97-103
30467864-5	2019	KEY FINDINGS: The active substances betulinic acid (BA) and ursolic acid (UA) strongly inhibited CYP3A4 activity while UA and lupeol moderately inhibited CYP2C19.	ursolic acid	119-121	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	154-161
30572191-7	2019	Taken together, inhibition of P-gp function and disruption of the metabolism of energy and related amino acids could be the key mechanisms by which UA could reverse the MDR.	ursolic acid	148-150	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
30772887-0	2019	Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway.	ursolic acid	0-12	mitogen-activated protein kinase 1	Homo sapiens	247-250
30572191-5	2019	The synergistic effects were yielded by the combination of UA and Dox based on the investigation of the intracellular accumulation, the P-glycoprotein (P-gp) mediated transport, the energy metabolism including glycolysis, tricarboxylic acid (TCA) cycle, and glutamine metabolism as well as related amino acid metabolism.	ursolic acid	59-61	ATP binding cassette subfamily B member 1	Homo sapiens	136-150
30772887-11	2019	Our investigation of the underlying mechanism revealed that ursolic acid prompts apoptotic cell death of the SK-MEL-24 cells, which was linked with increased expression of Bax and Caspase 3 and 9, and decreased expression of Bcl-2.	ursolic acid	60-72	BCL2 associated X, apoptosis regulator	Homo sapiens	172-175
30772887-11	2019	Our investigation of the underlying mechanism revealed that ursolic acid prompts apoptotic cell death of the SK-MEL-24 cells, which was linked with increased expression of Bax and Caspase 3 and 9, and decreased expression of Bcl-2.	ursolic acid	60-72	caspase 3	Homo sapiens	180-195
30772887-11	2019	Our investigation of the underlying mechanism revealed that ursolic acid prompts apoptotic cell death of the SK-MEL-24 cells, which was linked with increased expression of Bax and Caspase 3 and 9, and decreased expression of Bcl-2.	ursolic acid	60-72	BCL2 apoptosis regulator	Homo sapiens	225-230
30772887-12	2019	Ursolic acid also halted the SK-MEL-24 cells at G0/G1 phase of the cell cycle and also downregulated the expression of Cyclin B1 and Cdc25.	ursolic acid	0-12	cyclin B1	Homo sapiens	119-128
30772887-12	2019	Ursolic acid also halted the SK-MEL-24 cells at G0/G1 phase of the cell cycle and also downregulated the expression of Cyclin B1 and Cdc25.	ursolic acid	0-12	cell division cycle 25C	Homo sapiens	133-138
30772887-14	2019	Finally, ursolic acid inhibited the MAPK/ERK pathway by suppressing the expression of p-P38 and p-ERK.	ursolic acid	9-21	mitogen-activated protein kinase 1	Homo sapiens	41-44
30772887-14	2019	Finally, ursolic acid inhibited the MAPK/ERK pathway by suppressing the expression of p-P38 and p-ERK.	ursolic acid	9-21	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	96-101
30564129-7	2018	FLL and OA+UA also significantly induced renal CYP27B1 protein expression and OA+UA treatment decreased CYP24A1 mRNA and protein expressions in aged female rats.	ursolic acid	11-13	cytochrome P450, family 27, subfamily b, polypeptide 1	Rattus norvegicus	47-54
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	ursolic acid	46-48	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	178-184
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	ursolic acid	46-48	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	196-199
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	ursolic acid	46-48	Rous sarcoma oncogene	Mus musculus	201-204
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	ursolic acid	46-48	jun proto-oncogene	Mus musculus	206-211
30346064-4	2019	In short-term experiments, the combination of UA + Curc given topically prior to 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited activation of epidermal EGFR, p70S6K, NF-kappaB p50, Src, c-Jun, Rb, and IkappaBalpha.	ursolic acid	46-48	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	221-233
31061311-3	2019	Here, using cultured human colon cancer cell lines SW620 and HCT116, this assay demonstrates that UA reduces cell viability, inhibits cell clone formation, and induces caspase-3 mediated apoptosis.	ursolic acid	98-100	caspase 3	Homo sapiens	168-177
31061311-4	2019	Additional experiments show that UA inhibits cell migration and epithelial-mesenchymal transition (EMT), including E-cadherin, Vimentin, Integrin, Twist, and Zeb1 biomakers.	ursolic acid	33-35	cadherin 1	Homo sapiens	115-125
31061311-4	2019	Additional experiments show that UA inhibits cell migration and epithelial-mesenchymal transition (EMT), including E-cadherin, Vimentin, Integrin, Twist, and Zeb1 biomakers.	ursolic acid	33-35	vimentin	Homo sapiens	127-135
31061311-4	2019	Additional experiments show that UA inhibits cell migration and epithelial-mesenchymal transition (EMT), including E-cadherin, Vimentin, Integrin, Twist, and Zeb1 biomakers.	ursolic acid	33-35	zinc finger E-box binding homeobox 1	Homo sapiens	158-162
30597956-0	2018	Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation.	ursolic acid	0-12	Janus kinase 2	Homo sapiens	120-124
30597956-0	2018	Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation.	ursolic acid	0-12	signal transducer and activator of transcription 3	Homo sapiens	125-130
30597956-2	2018	Thus, in the present study, the apoptotic mechanism of ursolic acid was elucidated in HCT116 and HT29 colorectal cancer cells in association with STAT3 and microRNA-4500 (miR-4500) by MTT assay, Terminal deoxynucleotidyl transferase-dT-mediated dUTP nick end labelling (TUNEL) assay, cell cycle analysis, immunofluorescence, and Western blotting.	ursolic acid	55-67	signal transducer and activator of transcription 3	Homo sapiens	146-151
30597956-2	2018	Thus, in the present study, the apoptotic mechanism of ursolic acid was elucidated in HCT116 and HT29 colorectal cancer cells in association with STAT3 and microRNA-4500 (miR-4500) by MTT assay, Terminal deoxynucleotidyl transferase-dT-mediated dUTP nick end labelling (TUNEL) assay, cell cycle analysis, immunofluorescence, and Western blotting.	ursolic acid	55-67	microRNA 4500	Homo sapiens	171-179
30597956-2	2018	Thus, in the present study, the apoptotic mechanism of ursolic acid was elucidated in HCT116 and HT29 colorectal cancer cells in association with STAT3 and microRNA-4500 (miR-4500) by MTT assay, Terminal deoxynucleotidyl transferase-dT-mediated dUTP nick end labelling (TUNEL) assay, cell cycle analysis, immunofluorescence, and Western blotting.	ursolic acid	55-67	DNA nucleotidylexotransferase	Homo sapiens	195-232
30597956-3	2018	Ursolic acid significantly exerted cytotoxicity, increased TUNEL positive cells and sub-G1 apoptotic portion, induced cleavage of poly (adenosine diphosphate-ribose) polymerase (PARP) and caspase 3 in HCT116 and HT29 cells.	ursolic acid	0-12	caspase 3	Homo sapiens	188-197
30597956-4	2018	Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells.	ursolic acid	9-21	Janus kinase 2	Homo sapiens	83-97
30597956-4	2018	Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells.	ursolic acid	9-21	Janus kinase 2	Homo sapiens	99-103
30597956-4	2018	Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells.	ursolic acid	9-21	signal transducer and activator of transcription 3	Homo sapiens	109-159
30597956-4	2018	Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells.	ursolic acid	9-21	signal transducer and activator of transcription 3	Homo sapiens	161-166
30597956-4	2018	Of note, ursolic acid attenuated the expression of anti-apoptotic proteins such as Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) and also blocked nuclear translocation of STAT3 in colorectal cancer cells.	ursolic acid	9-21	signal transducer and activator of transcription 3	Homo sapiens	210-215
30597956-5	2018	Notably, ursolic acid increased the expression level of miR-4500 in HCT116 cells by qRT-PCR analysis and conversely miR-4500 inhibitor reversed cytotoxic, anti-proliferative, and apoptotic effects by increasing TUNEL positive cells, PARP cleavage and inhibiting p-STAT3 in ursolic acid treated colorectal cancer cells.	ursolic acid	9-21	microRNA 4500	Homo sapiens	56-64
30597956-5	2018	Notably, ursolic acid increased the expression level of miR-4500 in HCT116 cells by qRT-PCR analysis and conversely miR-4500 inhibitor reversed cytotoxic, anti-proliferative, and apoptotic effects by increasing TUNEL positive cells, PARP cleavage and inhibiting p-STAT3 in ursolic acid treated colorectal cancer cells.	ursolic acid	9-21	signal transducer and activator of transcription 3	Homo sapiens	264-269
30541946-0	2018	Ursolic acid stimulates UCP2 expression and protects H9c2 cells from hypoxia-reoxygenation injury via p38 signaling.	ursolic acid	0-12	uncoupling protein 2	Rattus norvegicus	24-28
30541946-0	2018	Ursolic acid stimulates UCP2 expression and protects H9c2 cells from hypoxia-reoxygenation injury via p38 signaling.	ursolic acid	0-12	mitogen activated protein kinase 14	Rattus norvegicus	102-105
30541946-4	2018	Here, among six natural compounds, ursolic acid (UA) had the most significant induction effect on UCP2 expression in H9c2 cells under H/R conditions.	ursolic acid	35-47	uncoupling protein 2	Rattus norvegicus	98-102
30541946-4	2018	Here, among six natural compounds, ursolic acid (UA) had the most significant induction effect on UCP2 expression in H9c2 cells under H/R conditions.	ursolic acid	49-51	uncoupling protein 2	Rattus norvegicus	98-102
30541946-5	2018	Subsequently, we found that UA significantly attenuated cell apoptosis and Caspase 3 activity, but increased nitric oxide (NO) release under H/R conditions.	ursolic acid	28-30	caspase 3	Rattus norvegicus	75-84
30541946-7	2018	H/R caused a notable increase in the phosphorylation of p38, which was weakened by UA pretreatment.	ursolic acid	83-85	mitogen activated protein kinase 14	Rattus norvegicus	56-59
30541946-8	2018	Moreover, p38 inhibitor (SB203580) showed the similar effects on H/R cells as UA pretreatment, while UCP2 knockdown had the reverse biological effects.	ursolic acid	78-80	mitogen activated protein kinase 14	Rattus norvegicus	10-13
30541946-10	2018	Collectively, our data suggested the functions of UA on UCP2 expression and on the protection of H/Rstimulated H9c2 cells may be attributed to p38 signaling pathway.	ursolic acid	50-52	uncoupling protein 2	Rattus norvegicus	56-60
30541946-10	2018	Collectively, our data suggested the functions of UA on UCP2 expression and on the protection of H/Rstimulated H9c2 cells may be attributed to p38 signaling pathway.	ursolic acid	50-52	mitogen activated protein kinase 14	Rattus norvegicus	143-146
30359008-0	2018	Ursolic Acid, a Novel Liver X Receptor alpha (LXRalpha) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis.	ursolic acid	0-12	nuclear receptor subfamily 1, group H, member 3	Mus musculus	22-44
30643062-5	2018	However, after ursolic acid treatment, the migration and invasion ability were significantly reduced, and the expression of E-cadherin was increased while N-cadherin and vimentin levels were decreased.	ursolic acid	15-27	cadherin 1	Homo sapiens	124-134
30643062-5	2018	However, after ursolic acid treatment, the migration and invasion ability were significantly reduced, and the expression of E-cadherin was increased while N-cadherin and vimentin levels were decreased.	ursolic acid	15-27	cadherin 2	Homo sapiens	155-165
30643062-5	2018	However, after ursolic acid treatment, the migration and invasion ability were significantly reduced, and the expression of E-cadherin was increased while N-cadherin and vimentin levels were decreased.	ursolic acid	15-27	vimentin	Homo sapiens	170-178
30359008-0	2018	Ursolic Acid, a Novel Liver X Receptor alpha (LXRalpha) Antagonist Inhibiting Ligand-Induced Nonalcoholic Fatty Liver and Drug-Induced Lipogenesis.	ursolic acid	0-12	nuclear receptor subfamily 1, group H, member 3	Mus musculus	46-54
30359008-4	2018	Ursolic acid (UA) is a plant triterpenoid with many beneficial effects; however, the mechanism of its action on LXRalpha remains elusive.	ursolic acid	0-12	nuclear receptor subfamily 1, group H, member 3	Mus musculus	112-120
30359008-5	2018	We evaluated the effects of UA on T0901317 (T090)-induced LXRalpha activation and steatosis.	ursolic acid	28-30	nuclear receptor subfamily 1, group H, member 3	Mus musculus	58-66
30359008-6	2018	UA significantly decreased the LXR response element and sterol regulatory element-binding protein-1c ( SREBP-1c) gene promoter activities, mRNA, protein expression of LXRalpha target genes, and hepatic cellular lipid content in a T090-induced mouse model.	ursolic acid	0-2	nuclear receptor subfamily 1, group H, member 3	Mus musculus	31-34
30359008-6	2018	UA significantly decreased the LXR response element and sterol regulatory element-binding protein-1c ( SREBP-1c) gene promoter activities, mRNA, protein expression of LXRalpha target genes, and hepatic cellular lipid content in a T090-induced mouse model.	ursolic acid	0-2	sterol regulatory element binding transcription factor 1	Mus musculus	56-100
30359008-6	2018	UA significantly decreased the LXR response element and sterol regulatory element-binding protein-1c ( SREBP-1c) gene promoter activities, mRNA, protein expression of LXRalpha target genes, and hepatic cellular lipid content in a T090-induced mouse model.	ursolic acid	0-2	sterol regulatory element binding transcription factor 1	Mus musculus	103-111
30359008-6	2018	UA significantly decreased the LXR response element and sterol regulatory element-binding protein-1c ( SREBP-1c) gene promoter activities, mRNA, protein expression of LXRalpha target genes, and hepatic cellular lipid content in a T090-induced mouse model.	ursolic acid	0-2	nuclear receptor subfamily 1, group H, member 3	Mus musculus	167-175
30359008-7	2018	A molecular docking study indicated that UA bound competitively with T090 at the LXRalpha ligand binding domain.	ursolic acid	41-43	nuclear receptor subfamily 1, group H, member 3	Mus musculus	81-89
30359008-8	2018	UA stimulated AMP-activated protein kinase (AMPK) phosphorylation in hepatic cells and increased corepressor, small heterodimer partner-interacting leucine zipper protein (SMILE) but decreased coactivator, steroid receptor coactivator-1 (SRC-1) recruitment to the SREBP-1c promoter region.	ursolic acid	0-2	CREB/ATF bZIP transcription factor	Mus musculus	110-170
30359008-8	2018	UA stimulated AMP-activated protein kinase (AMPK) phosphorylation in hepatic cells and increased corepressor, small heterodimer partner-interacting leucine zipper protein (SMILE) but decreased coactivator, steroid receptor coactivator-1 (SRC-1) recruitment to the SREBP-1c promoter region.	ursolic acid	0-2	CREB/ATF bZIP transcription factor	Mus musculus	172-177
30359008-8	2018	UA stimulated AMP-activated protein kinase (AMPK) phosphorylation in hepatic cells and increased corepressor, small heterodimer partner-interacting leucine zipper protein (SMILE) but decreased coactivator, steroid receptor coactivator-1 (SRC-1) recruitment to the SREBP-1c promoter region.	ursolic acid	0-2	nuclear receptor coactivator 1	Mus musculus	206-236
30359008-8	2018	UA stimulated AMP-activated protein kinase (AMPK) phosphorylation in hepatic cells and increased corepressor, small heterodimer partner-interacting leucine zipper protein (SMILE) but decreased coactivator, steroid receptor coactivator-1 (SRC-1) recruitment to the SREBP-1c promoter region.	ursolic acid	0-2	nuclear receptor coactivator 1	Mus musculus	238-243
30359008-8	2018	UA stimulated AMP-activated protein kinase (AMPK) phosphorylation in hepatic cells and increased corepressor, small heterodimer partner-interacting leucine zipper protein (SMILE) but decreased coactivator, steroid receptor coactivator-1 (SRC-1) recruitment to the SREBP-1c promoter region.	ursolic acid	0-2	sterol regulatory element binding transcription factor 1	Mus musculus	264-272
30359008-9	2018	In contrast, UA induced SRC-1 binding but decreased SMILE binding to reverse cholesterol transport-related gene promoters in intestinal cells, increasing lipid excretion from intestinal cells.	ursolic acid	13-15	nuclear receptor coactivator 1	Mus musculus	24-29
30359008-9	2018	In contrast, UA induced SRC-1 binding but decreased SMILE binding to reverse cholesterol transport-related gene promoters in intestinal cells, increasing lipid excretion from intestinal cells.	ursolic acid	13-15	CREB/ATF bZIP transcription factor	Mus musculus	52-57
30157245-4	2018	Recent studies show that the natural compound ursolic acid (UA) enhances mTOR signaling intermediates, independently inhibiting atrophy and inducing hypertrophy.	ursolic acid	46-58	mechanistic target of rapamycin kinase	Mus musculus	73-77
29672850-0	2018	Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway.	ursolic acid	0-12	C-C motif chemokine ligand 4	Homo sapiens	25-29
29672850-4	2018	In this study, we verified that UA could alleviate CCl4-induced liver fibrosis by reducing the expression of NOXs/ROS in HCs, HSCs, KCs.	ursolic acid	32-34	C-C motif chemokine ligand 4	Homo sapiens	51-55
30214619-9	2018	Mechanistically, RME and UA inhibited G1-S phase transition resulting in an increased G1:S+G2/M ratio and decreased cyclin D1 expression.	ursolic acid	25-27	cyclin D1	Homo sapiens	116-125
29383876-1	2018	SCOPE: This study aims to investigate the role of the epigenetic regulator SET domain-containing lysine methyltransferase 7 (Setd7) in regulating the antioxidant Nrf2 pathway in prostate cancer (PCa) cells and examines the effects of two phytochemicals, phenethyl isothiocyanate (PEITC) and ursolic acid (UA).	ursolic acid	291-303	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	125-130
29383876-1	2018	SCOPE: This study aims to investigate the role of the epigenetic regulator SET domain-containing lysine methyltransferase 7 (Setd7) in regulating the antioxidant Nrf2 pathway in prostate cancer (PCa) cells and examines the effects of two phytochemicals, phenethyl isothiocyanate (PEITC) and ursolic acid (UA).	ursolic acid	291-303	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
29383876-1	2018	SCOPE: This study aims to investigate the role of the epigenetic regulator SET domain-containing lysine methyltransferase 7 (Setd7) in regulating the antioxidant Nrf2 pathway in prostate cancer (PCa) cells and examines the effects of two phytochemicals, phenethyl isothiocyanate (PEITC) and ursolic acid (UA).	ursolic acid	305-307	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	125-130
29383876-1	2018	SCOPE: This study aims to investigate the role of the epigenetic regulator SET domain-containing lysine methyltransferase 7 (Setd7) in regulating the antioxidant Nrf2 pathway in prostate cancer (PCa) cells and examines the effects of two phytochemicals, phenethyl isothiocyanate (PEITC) and ursolic acid (UA).	ursolic acid	305-307	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
29383876-6	2018	Interestingly, Setd7 expression could be induced by the dietary phytochemicals PEITC and UA.	ursolic acid	89-91	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	15-20
29383876-8	2018	CONCLUSION: Taken together, these results indicate that Setd7 knockdown decreases Nrf2 and Nrf2-target genes expression and that PEITC and UA induce Setd7 expression, which activates the Nrf2/antioxidant response element (ARE) signaling pathway and protects DNA from oxidative damage.	ursolic acid	139-141	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
29383876-8	2018	CONCLUSION: Taken together, these results indicate that Setd7 knockdown decreases Nrf2 and Nrf2-target genes expression and that PEITC and UA induce Setd7 expression, which activates the Nrf2/antioxidant response element (ARE) signaling pathway and protects DNA from oxidative damage.	ursolic acid	139-141	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	149-154
29383876-8	2018	CONCLUSION: Taken together, these results indicate that Setd7 knockdown decreases Nrf2 and Nrf2-target genes expression and that PEITC and UA induce Setd7 expression, which activates the Nrf2/antioxidant response element (ARE) signaling pathway and protects DNA from oxidative damage.	ursolic acid	139-141	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
30265541-0	2018	Modification of Cysteine 179 in IKKbeta by Ursolic Acid Inhibits Titanium-Wear-Particle-Induced Inflammation, Osteoclastogenesis, and Hydroxylapatite Resorption.	ursolic acid	43-55	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	32-39
30265541-3	2018	In the present study, that the suppressive effect of UA on Ti-particle-induced inflammation and osteoclastogenesis targets on IKKbeta cys-179 was demonstrated.	ursolic acid	53-55	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	126-133
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	nitric oxide synthase 2	Homo sapiens	166-170
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	tumor necrosis factor	Homo sapiens	206-215
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	interleukin 1 beta	Homo sapiens	217-225
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	interleukin 6	Homo sapiens	231-235
30265541-8	2018	As a result, a mutation of IKKbetaC179A rescued the therapeutic effect of UA on Ti-particle-induced inflammation, including morphological transforms, upregulation of iNOS and COX-2, increased secretions of TNF-alpha, IL-1beta, and IL-6, and decreased secretion of IL-10.	ursolic acid	74-76	interleukin 10	Homo sapiens	264-269
30265541-10	2018	Phosphorylations of p65 and the IKKalpha/beta complex and translocation of p65 into the nucleus were suppressed by UA but rescued by a mutation of IKKbetaC179A.	ursolic acid	115-117	RELA proto-oncogene, NF-kB subunit	Homo sapiens	20-23
30265541-10	2018	Phosphorylations of p65 and the IKKalpha/beta complex and translocation of p65 into the nucleus were suppressed by UA but rescued by a mutation of IKKbetaC179A.	ursolic acid	115-117	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	32-45
30265541-10	2018	Phosphorylations of p65 and the IKKalpha/beta complex and translocation of p65 into the nucleus were suppressed by UA but rescued by a mutation of IKKbetaC179A.	ursolic acid	115-117	RELA proto-oncogene, NF-kB subunit	Homo sapiens	75-78
30221655-0	2018	Ursolic acid alleviates inflammation and against diabetes-induced nephropathy through TLR4-mediated inflammatory pathway.	ursolic acid	0-12	toll-like receptor 4	Mus musculus	86-90
30221655-7	2018	The inhibition of TLR4 increased the anti-inflammation of UA on inflammation in rat with diabetes-induced nephropathy through the TLR4 signaling pathway.	ursolic acid	58-60	toll-like receptor 4	Rattus norvegicus	18-22
30221655-7	2018	The inhibition of TLR4 increased the anti-inflammation of UA on inflammation in rat with diabetes-induced nephropathy through the TLR4 signaling pathway.	ursolic acid	58-60	toll-like receptor 4	Rattus norvegicus	130-134
30221655-8	2018	In conclusion, UA alleviates inflammation and inhibits diabetes-induced nephropathy through a TLR4-mediated inflammatory pathway.	ursolic acid	15-17	toll-like receptor 4	Mus musculus	94-98
29778798-1	2018	A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing long-chain diamine moieties were designed and synthesized as well as evaluated the antitumor effects.	ursolic acid	45-57	nuclear factor kappa B subunit 1	Homo sapiens	26-35
29778798-1	2018	A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing long-chain diamine moieties were designed and synthesized as well as evaluated the antitumor effects.	ursolic acid	59-61	nuclear factor kappa B subunit 1	Homo sapiens	26-35
30021385-18	2018	Furthermore, renal structural abnormalities and the elevation of TNF-alpha, MCP-1 and IL-1beta expression level were blocked by the administration of UA.	ursolic acid	150-152	tumor necrosis factor	Rattus norvegicus	65-74
30021385-18	2018	Furthermore, renal structural abnormalities and the elevation of TNF-alpha, MCP-1 and IL-1beta expression level were blocked by the administration of UA.	ursolic acid	150-152	mast cell protease 1-like 1	Rattus norvegicus	76-81
30021385-18	2018	Furthermore, renal structural abnormalities and the elevation of TNF-alpha, MCP-1 and IL-1beta expression level were blocked by the administration of UA.	ursolic acid	150-152	interleukin 1 beta	Rattus norvegicus	86-94
29383876-0	2018	Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells.	ursolic acid	97-109	PR/SET domain 9	Homo sapiens	0-25
29383876-0	2018	Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells.	ursolic acid	97-109	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	26-31
29383876-0	2018	Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells.	ursolic acid	97-109	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
30181206-0	2018	Editor"s Note: Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells.	ursolic acid	15-27	signal transducer and activator of transcription 3	Homo sapiens	37-42
29956797-0	2018	Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin-resistant oral cancer CAR cells.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	92-95
29956797-6	2018	Ursolic acid also increased the activities of caspase-3 and caspase-9 in CAR cells, determined by a colorimetric assay.	ursolic acid	0-12	caspase 3	Homo sapiens	46-55
29956797-6	2018	Ursolic acid also increased the activities of caspase-3 and caspase-9 in CAR cells, determined by a colorimetric assay.	ursolic acid	0-12	caspase 9	Homo sapiens	60-69
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	AKT serine/threonine kinase 1	Homo sapiens	93-96
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 apoptosis regulator	Homo sapiens	110-127
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 apoptosis regulator	Homo sapiens	129-134
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 apoptosis regulator	Homo sapiens	210-215
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 like 1	Homo sapiens	237-243
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 associated X, apoptosis regulator	Homo sapiens	286-304
29956797-8	2018	The apoptosis-associated signaling showed that ursolic acid decreased the phosphorylation of AKT (Ser473) and B-cell lymphoma 2 (Bcl-2)-associated agonist of cell death (BAD; Ser136), and the protein levels of Bcl-2 and Bcl-extra large (Bcl-xL), and increased the expression of BAD and Bcl-2-associated X (Bax) protein in CAR cells.	ursolic acid	47-59	BCL2 associated X, apoptosis regulator	Homo sapiens	306-309
30154452-8	2018	Finally, several anti-inflammatory drugs, including resveratrol, aspirin, vitamin E and ursolic acid, significantly increased the levels of the HIPK2 mRNA and protein by modulating promoter activity and the 3"-UTR stability of the HIPK2 gene.	ursolic acid	88-100	homeodomain interacting protein kinase 2	Mus musculus	144-149
30154452-8	2018	Finally, several anti-inflammatory drugs, including resveratrol, aspirin, vitamin E and ursolic acid, significantly increased the levels of the HIPK2 mRNA and protein by modulating promoter activity and the 3"-UTR stability of the HIPK2 gene.	ursolic acid	88-100	homeodomain interacting protein kinase 2	Mus musculus	231-236
30157245-4	2018	Recent studies show that the natural compound ursolic acid (UA) enhances mTOR signaling intermediates, independently inhibiting atrophy and inducing hypertrophy.	ursolic acid	60-62	mechanistic target of rapamycin kinase	Mus musculus	73-77
30157245-5	2018	Here, we examine the effects of UA treatment on sub-lesional muscle mTOR signaling, catabolic genes, and functional deficits following severe SCI in mice.	ursolic acid	32-34	mechanistic target of rapamycin kinase	Mus musculus	68-72
30157245-6	2018	We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11.	ursolic acid	16-18	mechanistic target of rapamycin kinase	Mus musculus	98-102
30157245-6	2018	We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11.	ursolic acid	16-18	thymoma viral proto-oncogene 1	Mus musculus	138-141
30157245-6	2018	We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11.	ursolic acid	16-18	forkhead box O1	Mus musculus	202-207
30157245-6	2018	We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11.	ursolic acid	16-18	F-box protein 32	Mus musculus	209-214
30157245-6	2018	We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11.	ursolic acid	16-18	tripartite motif-containing 63	Mus musculus	216-222
30157245-6	2018	We observe that UA treatment significantly attenuates SCI induced decreases in activated forms of mTOR, and signaling intermediates PI3K, AKT, and S6K, and the upregulation of catabolic genes including FOXO1, MAFbx, MURF-1, and PSMD11.	ursolic acid	16-18	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Mus musculus	228-234
29758202-0	2018	Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1.	ursolic acid	28-40	sirtuin 1	Mus musculus	60-65
30114281-0	2018	Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations.	ursolic acid	109-121	xanthine dehydrogenase	Mus musculus	22-38
30104508-0	2018	Ursolic Acid-Induced Apoptosis via Regulation of the PI3K/Akt and MAPK Signaling Pathways in Huh-7 Cells.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	58-61
30104508-0	2018	Ursolic Acid-Induced Apoptosis via Regulation of the PI3K/Akt and MAPK Signaling Pathways in Huh-7 Cells.	ursolic acid	0-12	MIR7-3 host gene	Homo sapiens	93-98
30104508-2	2018	In this article, the effects of UA on apoptosis and the proliferation of human hepatoma Huh-7 cells were reported.	ursolic acid	32-34	MIR7-3 host gene	Homo sapiens	88-93
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	BCL2 apoptosis regulator	Homo sapiens	112-117
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	119-124
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	tumor protein, translationally-controlled 1	Homo sapiens	130-134
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	tumor necrosis factor	Homo sapiens	179-188
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	Fas associated via death domain	Homo sapiens	195-199
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	BCL2 associated X, apoptosis regulator	Homo sapiens	205-208
30104508-6	2018	The results showed that exposure to UA affected extrinsic and intrinsic pathways through, reduced expression of Bcl-2, Mcl-1, and TCTP; increased levels of the apoptotic proteins TNF-alpha, Fas, FADD, and Bax; and activation of cleaved caspase-3 and PARP.	ursolic acid	36-38	collagen type XI alpha 2 chain	Homo sapiens	250-254
30104508-7	2018	UA also inhibited the p-Akt and p38 MAPK signaling transduction pathways, and increased activity in the p-ERK signaling pathway.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	24-27
30104508-7	2018	UA also inhibited the p-Akt and p38 MAPK signaling transduction pathways, and increased activity in the p-ERK signaling pathway.	ursolic acid	0-2	mitogen-activated protein kinase 14	Homo sapiens	32-35
30104508-8	2018	Taken together, UA inhibited the cell growth of Huh-7 cells and affected apoptosis, via regulated cellular signaling transduction.	ursolic acid	16-18	MIR7-3 host gene	Homo sapiens	48-53
30015296-6	2018	RESULTS: Both dietary UA and 23-OHUA prevented dyslipidemia-induced loss of MKP-1 activity, and hyper-chemotactic activity, hallmarks of blood monocytes priming and dysfunction, but they did not affect plasma lipids or blood glucose levels nor WBC and monocyte counts.	ursolic acid	22-24	dual specificity phosphatase 1	Mus musculus	76-81
32454656-8	2018	Results: Ursolic acid treatment was found to significantly decrease DNA damage, GR enzyme activities, and MDA levels, and significantly increase GSH levels and CAT, SOD and GSH-Px enzyme activities in diabetic rats.	ursolic acid	9-21	catalase	Rattus norvegicus	160-163
30057155-5	2018	Biological investigations showed that (+)-ursolic acid (1) is the major cytotoxic component of S. corticosum, which exhibited also potent activities in the NF-kappaB and mitochondrial transmembrane potential (MTP) inhibition assays conducted, with IC50 values of 31 nM and 3.5 microM, respectively.	ursolic acid	38-54	nuclear factor kappa B subunit 1	Homo sapiens	156-165
29758202-0	2018	Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1.	ursolic acid	28-40	sirtuin 1	Mus musculus	119-124
29758202-2	2018	However, the role of UA in the regulation of aging and longevity is still controversial as we have previously demonstrated that UA increases SIRT1 protein level in aged-mice.	ursolic acid	128-130	sirtuin 1	Mus musculus	141-146
29758202-3	2018	Here, we reveal that UA directly activates SIRT1 in silico, in vitro and in vivo.	ursolic acid	21-23	sirtuin 1	Mus musculus	43-48
29758202-4	2018	We have identified that UA binds to outer surface of SIRT1 and leads to tight binding of substrates to enzyme in comparison with Resveratrol (RSV) and control.	ursolic acid	24-26	sirtuin 1	Mus musculus	53-58
29758202-5	2018	Furthermore, our results indicate that UA drives the structure of SIRT1 toward a closed state (an active form of enzyme).	ursolic acid	39-41	sirtuin 1	Mus musculus	66-71
29758202-10	2018	According to our results, it can be concluded that UA increases SIRT1 activity and mimics Lamin A and AROS behavior in the living cells.	ursolic acid	51-53	sirtuin 1	Mus musculus	64-69
29758202-10	2018	According to our results, it can be concluded that UA increases SIRT1 activity and mimics Lamin A and AROS behavior in the living cells.	ursolic acid	51-53	lamin A	Mus musculus	90-97
29499360-0	2018	Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.	ursolic acid	0-12	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	22-36
29867706-0	2018	Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFkappaB Pathway.	ursolic acid	0-12	high mobility group box 1	Rattus norvegicus	95-120
29867706-0	2018	Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFkappaB Pathway.	ursolic acid	0-12	toll-like receptor 4	Rattus norvegicus	121-141
29867706-10	2018	UA (10 and 20 mg/kg) treatment significantly decreased the neurological deficit scores, infarct volume, apoptotic cells, and IL-1beta, TNF-alpha, and IL-6 concentrations.	ursolic acid	0-2	interleukin 1 beta	Rattus norvegicus	125-133
29867706-10	2018	UA (10 and 20 mg/kg) treatment significantly decreased the neurological deficit scores, infarct volume, apoptotic cells, and IL-1beta, TNF-alpha, and IL-6 concentrations.	ursolic acid	0-2	tumor necrosis factor	Rattus norvegicus	135-144
29867706-10	2018	UA (10 and 20 mg/kg) treatment significantly decreased the neurological deficit scores, infarct volume, apoptotic cells, and IL-1beta, TNF-alpha, and IL-6 concentrations.	ursolic acid	0-2	interleukin 6	Rattus norvegicus	150-154
29867706-12	2018	Furthermore, UA (10 and 20 mg/kg) treatment significantly decreased HMGB1 release and the TLR4 level and inactivated NFkappaB signaling.	ursolic acid	13-15	high mobility group box 1	Rattus norvegicus	68-73
29867706-12	2018	Furthermore, UA (10 and 20 mg/kg) treatment significantly decreased HMGB1 release and the TLR4 level and inactivated NFkappaB signaling.	ursolic acid	13-15	toll-like receptor 4	Rattus norvegicus	90-94
29867706-14	2018	We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NFkappaB signaling pathway.	ursolic acid	31-33	high mobility group box 1	Rattus norvegicus	163-168
29867706-14	2018	We provide novel evidence that UA reduces inflammatory cytokine production to protect the brain from cerebral ischemia and reperfusion injury possibly through the HMGB1/TLR4/NFkappaB signaling pathway.	ursolic acid	31-33	toll-like receptor 4	Rattus norvegicus	169-173
29567576-0	2018	The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse.	ursolic acid	50-62	beta-1,3-glucuronyltransferase 1	Homo sapiens	28-33
29567576-2	2018	We have recently identified the small organic compound ursolic acid (UA) as a HNK-1 mimetic with the aim to test its therapeutic potential in the central nervous system.	ursolic acid	55-67	beta-1,3-glucuronyltransferase 1	Homo sapiens	78-83
29567576-2	2018	We have recently identified the small organic compound ursolic acid (UA) as a HNK-1 mimetic with the aim to test its therapeutic potential in the central nervous system.	ursolic acid	69-71	beta-1,3-glucuronyltransferase 1	Homo sapiens	78-83
29567576-6	2018	UA administration decreased levels of proinflammatory markers, including interleukin-6 and tumor necrosis factor-alpha, in the injured spinal cord at the acute phase of inflammation and activated the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways in the injured spinal cord.	ursolic acid	0-2	interleukin 6	Homo sapiens	73-118
29568928-9	2018	The findings suggested that UA may protect against sepsis-induced AKI by inhibiting reactive oxygen species and inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, in the kidney from septic mice.	ursolic acid	28-30	tumor necrosis factor	Mus musculus	146-173
29568928-9	2018	The findings suggested that UA may protect against sepsis-induced AKI by inhibiting reactive oxygen species and inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, in the kidney from septic mice.	ursolic acid	28-30	interleukin 1 beta	Mus musculus	175-197
29568928-9	2018	The findings suggested that UA may protect against sepsis-induced AKI by inhibiting reactive oxygen species and inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6, in the kidney from septic mice.	ursolic acid	28-30	interleukin 6	Mus musculus	202-206
30788937-14	2018	CONCLUSIONS: Ursolic acid has a obvious protective effect on myocardial injury in mice with diabetes induced by high-fat diet combined with low dose streptozotocin, and its mechanism may be associated with inhibiting NLRP3 inflammasome activation, reducing IL-1beta generation and alleviating myocardial inflammatory injury.	ursolic acid	13-25	NLR family, pyrin domain containing 3	Mus musculus	217-222
30788937-14	2018	CONCLUSIONS: Ursolic acid has a obvious protective effect on myocardial injury in mice with diabetes induced by high-fat diet combined with low dose streptozotocin, and its mechanism may be associated with inhibiting NLRP3 inflammasome activation, reducing IL-1beta generation and alleviating myocardial inflammatory injury.	ursolic acid	13-25	interleukin 1 beta	Mus musculus	257-265
29408311-2	2018	In this work, a carrier-free nanodrug was developed by co-assembly of the anti-cancer agent ursolic acid (UA), an asialoglycoprotein receptor (ASGPR), which can recognize the target molecule lactobionic acid (LA), and the near-infrared (NIR) probe dye indocyanine green (ICG) to form UA-LA-ICG NPs by a simple and green self-assembly approach.	ursolic acid	92-104	asialoglycoprotein receptor 1	Homo sapiens	143-148
29408311-2	2018	In this work, a carrier-free nanodrug was developed by co-assembly of the anti-cancer agent ursolic acid (UA), an asialoglycoprotein receptor (ASGPR), which can recognize the target molecule lactobionic acid (LA), and the near-infrared (NIR) probe dye indocyanine green (ICG) to form UA-LA-ICG NPs by a simple and green self-assembly approach.	ursolic acid	106-108	asialoglycoprotein receptor 1	Homo sapiens	143-148
29408311-9	2018	STATEMENT OF SIGNIFICANCE: The present study for the first time reported carrier-free nanoparticles (NPs) by co-assembly of a natural product ursolic acid (UA), an asialoglycoprotein receptor (ASGPR)-recognized sugar molecule lactobionic acid (LA), and the near-infrared dye indocyanine green (ICG) through a simple and green approach.	ursolic acid	142-154	asialoglycoprotein receptor 1	Homo sapiens	193-198
29677678-4	2018	The limit of detection of the method for ursolic acid and oleanolic acid were 14 ng mL-1 and 13 ng mL-1, respectively.	ursolic acid	41-53	L1 cell adhesion molecule	Mus musculus	84-103
29799788-0	2018	Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1.	ursolic acid	0-12	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	105-109
29799788-0	2018	Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1.	ursolic acid	0-12	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	152-157
29799788-3	2018	In this study, we discovered that ursolic acid (UA), a plant-derived pentacyclic triterpenoid, selectively induces B-cell lymphoma 2 homology 3-only protein Noxa in human RASFs.	ursolic acid	34-46	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	157-161
29799788-3	2018	In this study, we discovered that ursolic acid (UA), a plant-derived pentacyclic triterpenoid, selectively induces B-cell lymphoma 2 homology 3-only protein Noxa in human RASFs.	ursolic acid	48-50	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	157-161
29799788-4	2018	We observed that UA-induced Noxa expression was followed by a consequent decrease in Mcl-1 expression in a dose-dependent manner.	ursolic acid	17-19	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	28-32
29799788-4	2018	We observed that UA-induced Noxa expression was followed by a consequent decrease in Mcl-1 expression in a dose-dependent manner.	ursolic acid	17-19	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	85-90
29799788-5	2018	Subsequent evaluation of the signaling pathways showed that UA-induced Noxa is primarily mediated by the JNK pathway in human RASFs.	ursolic acid	60-62	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	71-75
29799788-5	2018	Subsequent evaluation of the signaling pathways showed that UA-induced Noxa is primarily mediated by the JNK pathway in human RASFs.	ursolic acid	60-62	mitogen-activated protein kinase 8	Homo sapiens	105-108
29799788-7	2018	Furthermore, the results from IP studies and proximity ligation assays indicated that UA-induced Noxa colocalizes and associates with Mcl-1 to prime it for proteasomal degradation through K48-linked ubiquitination by the selective recruitment of Mcl-1 ubiquitin ligase E3, a homologous to E6-associated protein C terminus domain-containing E3 ubiquitin ligase.	ursolic acid	86-88	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	97-101
29799788-7	2018	Furthermore, the results from IP studies and proximity ligation assays indicated that UA-induced Noxa colocalizes and associates with Mcl-1 to prime it for proteasomal degradation through K48-linked ubiquitination by the selective recruitment of Mcl-1 ubiquitin ligase E3, a homologous to E6-associated protein C terminus domain-containing E3 ubiquitin ligase.	ursolic acid	86-88	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	134-139
29799788-7	2018	Furthermore, the results from IP studies and proximity ligation assays indicated that UA-induced Noxa colocalizes and associates with Mcl-1 to prime it for proteasomal degradation through K48-linked ubiquitination by the selective recruitment of Mcl-1 ubiquitin ligase E3, a homologous to E6-associated protein C terminus domain-containing E3 ubiquitin ligase.	ursolic acid	86-88	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	Homo sapiens	246-271
29735887-0	2018	Ursolic Acid Attenuates Atherosclerosis in ApoE-/- Mice: Role of LOX-1 Mediated by ROS/NF-kappaB Pathway.	ursolic acid	0-12	apolipoprotein E	Mus musculus	43-47
29735887-0	2018	Ursolic Acid Attenuates Atherosclerosis in ApoE-/- Mice: Role of LOX-1 Mediated by ROS/NF-kappaB Pathway.	ursolic acid	0-12	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	65-70
29735887-0	2018	Ursolic Acid Attenuates Atherosclerosis in ApoE-/- Mice: Role of LOX-1 Mediated by ROS/NF-kappaB Pathway.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
29735887-6	2018	The evaluation in vitro suggested that UA significantly decreased endothelial LOX-1 expression induced by LPS both in mRNA and protein levels.	ursolic acid	39-41	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	78-83
29735887-7	2018	Pre-treatment of UA also inhibited TLR4/MyD88 signaling activated by LPS.	ursolic acid	17-19	toll-like receptor 4	Mus musculus	35-39
29735887-7	2018	Pre-treatment of UA also inhibited TLR4/MyD88 signaling activated by LPS.	ursolic acid	17-19	myeloid differentiation primary response gene 88	Mus musculus	40-45
29735887-8	2018	Moreover, UA reduced ROS production and suppressed the activation of NF-kappaB stimulated by LPS.	ursolic acid	10-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
29735887-10	2018	In ApoE-/- mice fed with an atherogenic diet, both UA (100 mg/kg/day) and simvastatin significantly attenuated atherosclerotic plaque formation and shrunk necrotic core areas.	ursolic acid	51-53	apolipoprotein E	Mus musculus	3-7
29735887-11	2018	The enhanced expression of LOX-1 in atherosclerotic aorta was also dramatically decreased by administration of UA.	ursolic acid	111-113	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	27-32
29735887-12	2018	Taken together, these results suggested that UA, with anti-atherosclerotic activity through inhibition of LOX-1 mediated by ROS/NF-kappaB signaling pathways, may become a valuable vascular protective candidate for the treatment of atherosclerosis.	ursolic acid	45-47	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	106-111
29735887-12	2018	Taken together, these results suggested that UA, with anti-atherosclerotic activity through inhibition of LOX-1 mediated by ROS/NF-kappaB signaling pathways, may become a valuable vascular protective candidate for the treatment of atherosclerosis.	ursolic acid	45-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-137
29499360-0	2018	Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.	ursolic acid	0-12	apolipoprotein E	Mus musculus	74-90
29499360-2	2018	However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA.	ursolic acid	36-48	signal transducer and activator of transcription 3	Mus musculus	129-134
29499360-2	2018	However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA.	ursolic acid	36-48	a disintegrin and metallopeptidase domain 17	Mus musculus	139-145
29499360-2	2018	However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA.	ursolic acid	50-52	signal transducer and activator of transcription 3	Mus musculus	129-134
29499360-2	2018	However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, can have an impact on STAT3 and ADAM17 and hence influence the formation of AAA.	ursolic acid	50-52	a disintegrin and metallopeptidase domain 17	Mus musculus	139-145
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	elastin	Mus musculus	33-40
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	matrix metallopeptidase 2	Mus musculus	97-101
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	matrix metallopeptidase 9	Mus musculus	103-107
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	a disintegrin and metallopeptidase domain 17	Mus musculus	109-115
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	signal transducer and activator of transcription 3	Mus musculus	128-133
29499360-8	2018	UA alleviated the degradation of elastin fibers and inflammation and decreased the expression of MMP2, MMP9, ADAM17 and phospho-STAT3 (pSTAT3) in aorta of mice induced with AngII.	ursolic acid	0-2	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	173-178
29499360-9	2018	UA inhibited the constitutive and stimuli-induced (AngII and tumor necrosis factor-alpha) expression of MMP2, MMP9, ADAM17 and pSTAT3 in vascular smooth muscle cells (VSMCs).	ursolic acid	0-2	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	51-56
29499360-9	2018	UA inhibited the constitutive and stimuli-induced (AngII and tumor necrosis factor-alpha) expression of MMP2, MMP9, ADAM17 and pSTAT3 in vascular smooth muscle cells (VSMCs).	ursolic acid	0-2	tumor necrosis factor	Mus musculus	61-88
29499360-9	2018	UA inhibited the constitutive and stimuli-induced (AngII and tumor necrosis factor-alpha) expression of MMP2, MMP9, ADAM17 and pSTAT3 in vascular smooth muscle cells (VSMCs).	ursolic acid	0-2	matrix metallopeptidase 2	Mus musculus	104-108
29499360-9	2018	UA inhibited the constitutive and stimuli-induced (AngII and tumor necrosis factor-alpha) expression of MMP2, MMP9, ADAM17 and pSTAT3 in vascular smooth muscle cells (VSMCs).	ursolic acid	0-2	matrix metallopeptidase 9	Mus musculus	110-114
29499360-9	2018	UA inhibited the constitutive and stimuli-induced (AngII and tumor necrosis factor-alpha) expression of MMP2, MMP9, ADAM17 and pSTAT3 in vascular smooth muscle cells (VSMCs).	ursolic acid	0-2	a disintegrin and metallopeptidase domain 17	Mus musculus	116-122
29499360-11	2018	CONCLUSIONS: We demonstrated that UA ameliorated the severity of AAA and exhibited an inhibitory effect on the expression of pSTAT3 and ADAM17.	ursolic acid	34-36	a disintegrin and metallopeptidase domain 17	Mus musculus	136-142
29558494-0	2018	Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-alpha and IL-1: Pharmacological and docking studies.	ursolic acid	0-12	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	148-153
29595211-0	2018	Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	102-114	tumor protein p53	Homo sapiens	170-173
29595211-0	2018	Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	102-114	matrix metallopeptidase 9	Homo sapiens	174-179
29595211-0	2018	Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	102-114	phosphatase and tensin homolog	Homo sapiens	180-184
29595211-0	2018	Correction: A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	102-114	CD44 molecule (Indian blood group)	Homo sapiens	185-189
29595211-1	2018	Correction for "A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways" by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439.	ursolic acid	106-118	tumor protein p53	Homo sapiens	174-177
29595211-1	2018	Correction for "A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways" by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439.	ursolic acid	106-118	matrix metallopeptidase 9	Homo sapiens	178-183
29595211-1	2018	Correction for "A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways" by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439.	ursolic acid	106-118	phosphatase and tensin homolog	Homo sapiens	184-188
29595211-1	2018	Correction for "A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways" by Kai Jiang et al., Nanoscale, 2017, 9, 9428-9439.	ursolic acid	106-118	CD44 molecule (Indian blood group)	Homo sapiens	189-193
29558494-0	2018	Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-alpha and IL-1: Pharmacological and docking studies.	ursolic acid	0-12	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	155-160
29558494-0	2018	Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-alpha and IL-1: Pharmacological and docking studies.	ursolic acid	0-12	tumor necrosis factor	Rattus norvegicus	162-171
29030193-0	2018	Inhibitory mechanism of two allosteric inhibitors, oleanolic acid and ursolic acid on alpha-glucosidase.	ursolic acid	70-82	sucrase-isomaltase	Homo sapiens	86-103
29374711-6	2018	UA treatment induced the accumulation of p62 and increased the LC3-II/LC3-I ratio.	ursolic acid	0-2	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	41-44
29168472-4	2018	Molecular docking studies showed that ursolic acid might occupy the ubiquitin binding pocket of USP7, with the 17-carboxyl group and 3-hydroxyl group playing a vital role in the USP7-ursolic acid interaction.	ursolic acid	38-50	ubiquitin specific peptidase 7	Homo sapiens	96-100
29168472-4	2018	Molecular docking studies showed that ursolic acid might occupy the ubiquitin binding pocket of USP7, with the 17-carboxyl group and 3-hydroxyl group playing a vital role in the USP7-ursolic acid interaction.	ursolic acid	183-195	ubiquitin specific peptidase 7	Homo sapiens	178-182
29168472-5	2018	Using the cellular thermal shift assay, we demonstrated that ursolic acid interacted with USP7 in RPMI8226 human myeloma cells.	ursolic acid	61-73	ubiquitin specific peptidase 7	Homo sapiens	90-94
29168472-6	2018	Ursolic acid dose-dependently inhibited the proliferation of the myeloma cells with IC50 of 6.56 mumol/L, accompanied by reductions in USP7 substrates such as MDM2, UHRF1 and DNMT1.	ursolic acid	0-12	ubiquitin specific peptidase 7	Homo sapiens	135-139
29168472-6	2018	Ursolic acid dose-dependently inhibited the proliferation of the myeloma cells with IC50 of 6.56 mumol/L, accompanied by reductions in USP7 substrates such as MDM2, UHRF1 and DNMT1.	ursolic acid	0-12	MDM2 proto-oncogene	Homo sapiens	159-163
29168472-6	2018	Ursolic acid dose-dependently inhibited the proliferation of the myeloma cells with IC50 of 6.56 mumol/L, accompanied by reductions in USP7 substrates such as MDM2, UHRF1 and DNMT1.	ursolic acid	0-12	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	165-170
29168472-6	2018	Ursolic acid dose-dependently inhibited the proliferation of the myeloma cells with IC50 of 6.56 mumol/L, accompanied by reductions in USP7 substrates such as MDM2, UHRF1 and DNMT1.	ursolic acid	0-12	DNA methyltransferase 1	Homo sapiens	175-180
29168472-7	2018	Overexpression of USP7 partially, but significantly attenuated ursolic acid-induced cell death as well as downregulation of MDM2, UHRF1 and DNMT1.	ursolic acid	63-75	ubiquitin specific peptidase 7	Homo sapiens	18-22
29168472-8	2018	In conclusion, we demonstrate for the first time that pentacyclic triterpenes represent a novel scaffold for developing USP7 inhibitors and that USP7 inhibition contributes to the anti-cancer effect of ursolic acid.	ursolic acid	202-214	ubiquitin specific peptidase 7	Homo sapiens	145-149
29380400-2	2018	Thus, the aim of current work was to obtain seven ursolic acid derivatives as potential antidiabetic agents with PTP-1B inhibition as main mechanism of action.	ursolic acid	50-62	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	113-119
29435058-0	2018	Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1.	ursolic acid	0-12	phosphatase and tensin homolog	Homo sapiens	65-69
29435058-0	2018	Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1.	ursolic acid	0-12	cofilin 1	Homo sapiens	110-119
29435058-3	2018	The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer.	ursolic acid	51-63	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	153-184
29435058-3	2018	The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer.	ursolic acid	51-63	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	186-191
29435058-3	2018	The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer.	ursolic acid	51-63	phosphatase and tensin homolog	Homo sapiens	225-229
29435058-3	2018	The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer.	ursolic acid	268-280	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	153-184
29435058-3	2018	The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer.	ursolic acid	268-280	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	186-191
29435058-3	2018	The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer.	ursolic acid	268-280	phosphatase and tensin homolog	Homo sapiens	225-229
29435058-8	2018	In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities.	ursolic acid	48-60	phosphatase and tensin homolog	Homo sapiens	113-117
29435058-8	2018	In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities.	ursolic acid	48-60	cofilin 1	Homo sapiens	127-136
29435058-8	2018	In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities.	ursolic acid	48-60	cytochrome c, somatic	Homo sapiens	137-149
29435058-8	2018	In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities.	ursolic acid	48-60	caspase 3	Homo sapiens	165-174
29428962-0	2018	Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	116-119
29428962-0	2018	Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	120-149
29428962-0	2018	Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	156-159
29428962-0	2018	Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	160-164
29428962-9	2018	CONCLUSIONS UA attenuated mesangial cell proliferation and ROS generation by inhibiting HG-mediated PI3K/Akt/mTOR pathway activation, thereby ameliorating mesangial cell damage.	ursolic acid	12-14	AKT serine/threonine kinase 1	Homo sapiens	105-108
29428962-9	2018	CONCLUSIONS UA attenuated mesangial cell proliferation and ROS generation by inhibiting HG-mediated PI3K/Akt/mTOR pathway activation, thereby ameliorating mesangial cell damage.	ursolic acid	12-14	mechanistic target of rapamycin kinase	Homo sapiens	109-113
29030193-2	2018	This work is to investigate the kinetics and inhibition mechanism of oleanolic acid and ursolic acid on alpha-glucosidase.	ursolic acid	88-100	sucrase-isomaltase	Homo sapiens	104-121
29030193-5	2018	The binding constants of oleanolic acid and ursolic acid with alpha-glucosidase at 298K were (2.04+-0.02)x103 and (1.87+-0.02)x103Lmol-1, respectively.	ursolic acid	44-56	sucrase-isomaltase	Homo sapiens	62-79
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	ursolic acid	47-59	sucrase-isomaltase	Homo sapiens	124-141
29030193-6	2018	Docking results showed that oleanolic acid and ursolic acid bound in different allosteric sites of cavity 2 and cavity 4 on alpha-glucosidase, respectively, which triggered allosteric regulation to perturb conformational dynamics of alpha-glucosidase, eventually leading to a decrease of catalytic activity of the enzyme.	ursolic acid	47-59	sucrase-isomaltase	Homo sapiens	233-250
29030193-8	2018	The combination of oleanolic acid and ursolic acid displayed a significant synergistic inhibition on alpha-glucosidase.	ursolic acid	38-50	sucrase-isomaltase	Homo sapiens	101-118
29227654-4	2017	The combination of high concentration of UA (25, 50, 75, 100 muM) and Met (5, 10, 20, 40 mM) resulted in synergetic cytotoxicity on MDA-MB-231 and MCF-7 cells (CI &lt; 0.8).	ursolic acid	41-43	latexin	Homo sapiens	61-64
28558631-11	2018	In addition, it seems that UA by enhancing of SIRT6 expression promotes cholesterol homeostasis through repressing SREBP1 and SREBP2.	ursolic acid	27-29	sterol regulatory element binding factor 2	Mus musculus	126-132
28558631-13	2018	Finally, UA might be as key regulators of mineral homeostasis and bile acid/cholesterol metabolism, by inducing Klotho overexpression.	ursolic acid	9-11	klotho	Mus musculus	112-118
28852850-8	2018	In particular, the expression of pfk and pykF, coding for glycolysis regulatory proteins phosphofructokinase and pyruvate kinase, respectively, were significantly decreased in the OA and UA groups (P &lt; 0.05), as were genes involved in fatty acid and amino acid synthesis.	ursolic acid	187-189	6-phosphofructokinase	Streptococcus mutans UA159	33-36
28852850-8	2018	In particular, the expression of pfk and pykF, coding for glycolysis regulatory proteins phosphofructokinase and pyruvate kinase, respectively, were significantly decreased in the OA and UA groups (P &lt; 0.05), as were genes involved in fatty acid and amino acid synthesis.	ursolic acid	187-189	pyruvate kinase	Streptococcus mutans UA159	41-45
28852850-8	2018	In particular, the expression of pfk and pykF, coding for glycolysis regulatory proteins phosphofructokinase and pyruvate kinase, respectively, were significantly decreased in the OA and UA groups (P &lt; 0.05), as were genes involved in fatty acid and amino acid synthesis.	ursolic acid	187-189	pyruvate kinase	Streptococcus mutans UA159	113-128
30504678-1	2018	The pentacyclic triterpenoid ursolic acid was previously shown to inhibit the intracellular trafficking of intercellular adhesion molecule-1 (ICAM-1) from the endoplasmic reticulum (ER) to the Golgi apparatus.	ursolic acid	29-41	intercellular adhesion molecule 1	Homo sapiens	107-140
30504678-1	2018	The pentacyclic triterpenoid ursolic acid was previously shown to inhibit the intracellular trafficking of intercellular adhesion molecule-1 (ICAM-1) from the endoplasmic reticulum (ER) to the Golgi apparatus.	ursolic acid	29-41	intercellular adhesion molecule 1	Homo sapiens	142-148
30504678-2	2018	In the present study, we further investigated the biological activities of three pentacyclic triterpenoids closely related to ursolic acid on the interleukin 1alpha-induced expression and intracellular trafficking of ICAM-1.	ursolic acid	126-138	interleukin 1 alpha	Homo sapiens	146-164
30504678-2	2018	In the present study, we further investigated the biological activities of three pentacyclic triterpenoids closely related to ursolic acid on the interleukin 1alpha-induced expression and intracellular trafficking of ICAM-1.	ursolic acid	126-138	intercellular adhesion molecule 1	Homo sapiens	217-223
28558631-4	2018	The aim of this study is to address whether UA might alter sensors of the cell metabolic state such as SIRT1, SIRT6, PGC-1beta and Klotho proteins.	ursolic acid	44-46	sirtuin 1	Mus musculus	103-108
28558631-4	2018	The aim of this study is to address whether UA might alter sensors of the cell metabolic state such as SIRT1, SIRT6, PGC-1beta and Klotho proteins.	ursolic acid	44-46	sirtuin 6	Mus musculus	110-115
28558631-4	2018	The aim of this study is to address whether UA might alter sensors of the cell metabolic state such as SIRT1, SIRT6, PGC-1beta and Klotho proteins.	ursolic acid	44-46	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	117-126
28558631-4	2018	The aim of this study is to address whether UA might alter sensors of the cell metabolic state such as SIRT1, SIRT6, PGC-1beta and Klotho proteins.	ursolic acid	44-46	klotho	Mus musculus	131-137
28558631-7	2018	RESULTS: Our findings clearly illustrated that UA enhanced SIRT1 (~ 5 +- 0.2 folds) and SIRT6 (~ 8 +- 0.5 folds) proteins levels in hepatic, p&lt;0.001.	ursolic acid	47-49	sirtuin 1	Mus musculus	59-64
28558631-7	2018	RESULTS: Our findings clearly illustrated that UA enhanced SIRT1 (~ 5 +- 0.2 folds) and SIRT6 (~ 8 +- 0.5 folds) proteins levels in hepatic, p&lt;0.001.	ursolic acid	47-49	sirtuin 6	Mus musculus	88-93
28558631-9	2018	Moreover, we showed that UA upregulated Klotho (~ 3.5 +- 0.2 folds) protein in order to improve hepatic performance, p&lt;0.01.	ursolic acid	25-27	klotho	Mus musculus	40-46
28558631-11	2018	In addition, it seems that UA by enhancing of SIRT6 expression promotes cholesterol homeostasis through repressing SREBP1 and SREBP2.	ursolic acid	27-29	sirtuin 6	Mus musculus	46-51
28558631-11	2018	In addition, it seems that UA by enhancing of SIRT6 expression promotes cholesterol homeostasis through repressing SREBP1 and SREBP2.	ursolic acid	27-29	sterol regulatory element binding transcription factor 1	Mus musculus	115-121
30398111-7	2018	Furthermore classical and steered dynamics revealed the favourable hydrophobic interactions between the lupeol and the residues of flap or catalytic dyadof BACE1; however, ursolic acid showed disfavorable interactions with the BACE1.	ursolic acid	172-184	beta-secretase 1	Homo sapiens	227-232
28767174-0	2018	Inactivation of Beclin-1-dependent autophagy promotes ursolic acid-induced apoptosis in hypertrophic scar fibroblasts.	ursolic acid	54-66	beclin 1	Homo sapiens	16-24
28767174-8	2018	We found that UA inhibited collagen synthesis and induced cell apoptosis in HSFBs, evidenced by the deregulated expression of Bim, Bcl-2 and Cyto C. Furthermore, we demonstrated that UA induced autophagy and inactivation of autophagy promoted UA-induced apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	14-16	BCL2 like 11	Homo sapiens	126-129
28767174-8	2018	We found that UA inhibited collagen synthesis and induced cell apoptosis in HSFBs, evidenced by the deregulated expression of Bim, Bcl-2 and Cyto C. Furthermore, we demonstrated that UA induced autophagy and inactivation of autophagy promoted UA-induced apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	14-16	BCL2 apoptosis regulator	Homo sapiens	131-136
28767174-8	2018	We found that UA inhibited collagen synthesis and induced cell apoptosis in HSFBs, evidenced by the deregulated expression of Bim, Bcl-2 and Cyto C. Furthermore, we demonstrated that UA induced autophagy and inactivation of autophagy promoted UA-induced apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	183-185	BCL2 like 11	Homo sapiens	126-129
28767174-8	2018	We found that UA inhibited collagen synthesis and induced cell apoptosis in HSFBs, evidenced by the deregulated expression of Bim, Bcl-2 and Cyto C. Furthermore, we demonstrated that UA induced autophagy and inactivation of autophagy promoted UA-induced apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	183-185	BCL2 apoptosis regulator	Homo sapiens	131-136
28767174-8	2018	We found that UA inhibited collagen synthesis and induced cell apoptosis in HSFBs, evidenced by the deregulated expression of Bim, Bcl-2 and Cyto C. Furthermore, we demonstrated that UA induced autophagy and inactivation of autophagy promoted UA-induced apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	183-185	BCL2 like 11	Homo sapiens	126-129
28767174-8	2018	We found that UA inhibited collagen synthesis and induced cell apoptosis in HSFBs, evidenced by the deregulated expression of Bim, Bcl-2 and Cyto C. Furthermore, we demonstrated that UA induced autophagy and inactivation of autophagy promoted UA-induced apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	183-185	BCL2 apoptosis regulator	Homo sapiens	131-136
28767174-9	2018	Molecular investigation indicated that UA-induced autophagy through upregulation of Beclin-1 and knockdown of Beclin-1 prevent UA-induced autophagy.	ursolic acid	39-41	beclin 1	Homo sapiens	84-92
28767174-9	2018	Molecular investigation indicated that UA-induced autophagy through upregulation of Beclin-1 and knockdown of Beclin-1 prevent UA-induced autophagy.	ursolic acid	39-41	beclin 1	Homo sapiens	110-118
28767174-9	2018	Molecular investigation indicated that UA-induced autophagy through upregulation of Beclin-1 and knockdown of Beclin-1 prevent UA-induced autophagy.	ursolic acid	127-129	beclin 1	Homo sapiens	110-118
28767174-10	2018	Overexpression of Bcl-2 prevents UA-induced autophagy, Beclin-1 upregulation, apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	33-35	BCL2 apoptosis regulator	Homo sapiens	18-23
28767174-10	2018	Overexpression of Bcl-2 prevents UA-induced autophagy, Beclin-1 upregulation, apoptosis and collagen synthesis inhibition in HSFBs.	ursolic acid	33-35	beclin 1	Homo sapiens	55-63
28950243-0	2017	Design, synthesis, and evaluation of novel ursolic acid derivatives as HIF-1alpha inhibitors with anticancer potential.	ursolic acid	43-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
28950243-2	2017	In this work, four novel series of ursolic acid derivatives containing oxadiazole, triazolone, and piperazine moieties were designed, synthesized, and evaluated for anti-tumor activity as HIF-1alpha inhibitors.	ursolic acid	35-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	188-198
29128805-0	2017	Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2.	ursolic acid	0-12	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	93-100
29157826-0	2017	Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.	ursolic acid	97-109	nuclear receptor subfamily 1 group I member 2	Homo sapiens	14-33
29157826-0	2017	Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.	ursolic acid	97-109	nuclear receptor subfamily 1 group I member 3	Homo sapiens	44-76
29157826-0	2017	Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.	ursolic acid	97-109	nuclear receptor subfamily 1 group I member 3	Homo sapiens	78-81
29157826-0	2017	Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.	ursolic acid	111-113	nuclear receptor subfamily 1 group I member 2	Homo sapiens	14-33
29157826-0	2017	Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.	ursolic acid	111-113	nuclear receptor subfamily 1 group I member 3	Homo sapiens	44-76
29157826-0	2017	Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity.	ursolic acid	111-113	nuclear receptor subfamily 1 group I member 3	Homo sapiens	78-81
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	55-67	nuclear receptor subfamily 1 group I member 2	Homo sapiens	157-160
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	55-67	nuclear receptor subfamily 1 group I member 3	Homo sapiens	189-221
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	55-67	nuclear receptor subfamily 1 group I member 3	Homo sapiens	223-226
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	55-67	nuclear receptor subfamily 1 group I member 3	Homo sapiens	228-233
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	69-71	nuclear receptor subfamily 1 group I member 2	Homo sapiens	157-160
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	69-71	nuclear receptor subfamily 1 group I member 3	Homo sapiens	189-221
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	69-71	nuclear receptor subfamily 1 group I member 3	Homo sapiens	223-226
29157826-2	2017	PURPOSE: In the present study, we aim to identify that ursolic acid (UA), a widely distributed pentacyclic triterpene, may act as an effective antagonist of PXR and its sister NR receptor, constitutive androstane receptor (CAR, NR1I3).	ursolic acid	69-71	nuclear receptor subfamily 1 group I member 3	Homo sapiens	228-233
29157826-6	2017	RESULTS: Transient transfection assays showed that UA effectively attenuated CYP3A4 and CYP2B6 promoter activities mediated by rifampin (RIF, human PXR agonist) and CITCO (human CAR agonist).	ursolic acid	51-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
29157826-6	2017	RESULTS: Transient transfection assays showed that UA effectively attenuated CYP3A4 and CYP2B6 promoter activities mediated by rifampin (RIF, human PXR agonist) and CITCO (human CAR agonist).	ursolic acid	51-53	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	88-94
29157826-6	2017	RESULTS: Transient transfection assays showed that UA effectively attenuated CYP3A4 and CYP2B6 promoter activities mediated by rifampin (RIF, human PXR agonist) and CITCO (human CAR agonist).	ursolic acid	51-53	nuclear receptor subfamily 1 group I member 2	Homo sapiens	148-151
29157826-6	2017	RESULTS: Transient transfection assays showed that UA effectively attenuated CYP3A4 and CYP2B6 promoter activities mediated by rifampin (RIF, human PXR agonist) and CITCO (human CAR agonist).	ursolic acid	51-53	nuclear receptor subfamily 1 group I member 3	Homo sapiens	178-181
29098660-3	2017	The biological effects of ursolic acid have been evaluated in vitro, in different cell types and against several toxic insults (i.e. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, amyloid-beta peptides, kainic acid and others); in animal models of brain-related disorders (Alzheimer disease, Parkinson disease, depression, traumatic brain injury) and ageing; and in clinical studies with cancer patients and for muscle atrophy.	ursolic acid	26-38	amyloid beta precursor protein	Homo sapiens	179-191
28801966-0	2017	Ursolic Acid, a Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation-Associated Downstream Signal Transduction.	ursolic acid	0-12	caspase 3	Homo sapiens	53-61
29157826-8	2017	Furthermore, the interaction of co-regulators with PXR and the transcriptional complexes in the CYP3A4 promoter activity and CYP3A4 promoter xenobiotic response element (everted repeat 6, ER6), respectively, were disrupted in the presence of UA.	ursolic acid	242-244	nuclear receptor subfamily 1 group I member 2	Homo sapiens	51-54
29157826-8	2017	Furthermore, the interaction of co-regulators with PXR and the transcriptional complexes in the CYP3A4 promoter activity and CYP3A4 promoter xenobiotic response element (everted repeat 6, ER6), respectively, were disrupted in the presence of UA.	ursolic acid	242-244	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	96-102
29157826-8	2017	Furthermore, the interaction of co-regulators with PXR and the transcriptional complexes in the CYP3A4 promoter activity and CYP3A4 promoter xenobiotic response element (everted repeat 6, ER6), respectively, were disrupted in the presence of UA.	ursolic acid	242-244	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131
29157826-9	2017	UA showed an antagonistic effect against PXR, and reversed the cytotoxic effects of isoniazid (INH) induced by RIF.	ursolic acid	0-2	nuclear receptor subfamily 1 group I member 2	Homo sapiens	41-44
29157826-10	2017	Taken together, these results show that UA inhibits the transactivation effects of PXR and CAR, and reduces the expression and function of CYP3A4 and CYP2B6.	ursolic acid	40-42	nuclear receptor subfamily 1 group I member 2	Homo sapiens	83-86
29157826-10	2017	Taken together, these results show that UA inhibits the transactivation effects of PXR and CAR, and reduces the expression and function of CYP3A4 and CYP2B6.	ursolic acid	40-42	nuclear receptor subfamily 1 group I member 3	Homo sapiens	91-94
29157826-10	2017	Taken together, these results show that UA inhibits the transactivation effects of PXR and CAR, and reduces the expression and function of CYP3A4 and CYP2B6.	ursolic acid	40-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145
29157826-10	2017	Taken together, these results show that UA inhibits the transactivation effects of PXR and CAR, and reduces the expression and function of CYP3A4 and CYP2B6.	ursolic acid	40-42	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	150-156
29128805-0	2017	Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2.	ursolic acid	0-12	mitogen-activated protein kinase kinase 1	Mus musculus	105-111
29128805-6	2017	CONCLUSIONS: These results suggest that activation of PKA, PKC, CAMK-II, MEK1/2 may underlie the antidepressant-like effects of ursolic acid.	ursolic acid	128-140	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	64-71
29128805-6	2017	CONCLUSIONS: These results suggest that activation of PKA, PKC, CAMK-II, MEK1/2 may underlie the antidepressant-like effects of ursolic acid.	ursolic acid	128-140	mitogen-activated protein kinase kinase 1	Mus musculus	73-79
28964635-3	2017	For alpha-glucosidase inhibition, the IC50 values of ursolic acid, corosolic acid, betulinic acid, and oleanolic acid were 12.1+-1.0muM, 17.2+-0.9muM, 14.9+-1.9muM, and 35.6+-2.6muM, respectively.	ursolic acid	53-65	sucrase-isomaltase	Homo sapiens	4-21
29798594-10	2017	However, with the ursolic acid concentration increasing, the relative expressions of pro-Caspase-3 protein decreased and the relative expressions of activated Caspase-3 increased; there were significant differences between groups ( P&lt;0.05).	ursolic acid	18-30	caspase 3	Homo sapiens	85-98
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	monoamine oxidase A	Homo sapiens	71-76
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	monoamine oxidase B	Homo sapiens	81-86
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	Leucine transport, high	Homo sapiens	88-92
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	solute carrier family 6 member 4	Homo sapiens	107-111
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	solute carrier family 6 member 2	Homo sapiens	113-116
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	solute carrier family 6 member 3	Homo sapiens	118-121
28034283-3	2017	METHODS: Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.	ursolic acid	9-21	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	144-148
28034283-5	2017	CONCLUSION: Significant binding affinity of ursolic acid was seen with MAO-A, which indicated its potential role in other neurological disorders, for example, Alzheimer"s disease and Parkinson disease besides depression.	ursolic acid	44-56	monoamine oxidase A	Homo sapiens	71-76
29798594-10	2017	However, with the ursolic acid concentration increasing, the relative expressions of pro-Caspase-3 protein decreased and the relative expressions of activated Caspase-3 increased; there were significant differences between groups ( P&lt;0.05).	ursolic acid	18-30	caspase 3	Homo sapiens	89-98
29798594-11	2017	Conclusion: Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS, induce the down-regulation of cyclin D1 expression leading to G 0/G 1 phase arrest, increase the activation of Caspase-3 and promote cell apoptosis.	ursolic acid	12-24	cyclin D1	Homo sapiens	130-139
29798594-11	2017	Conclusion: Ursolic acid can effectively inhibit the proliferation of osteosarcoma cell line U2-OS, induce the down-regulation of cyclin D1 expression leading to G 0/G 1 phase arrest, increase the activation of Caspase-3 and promote cell apoptosis.	ursolic acid	12-24	caspase 3	Homo sapiens	211-220
29077044-7	2017	Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b1, tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified.	ursolic acid	69-81	kallikrein related peptidase 5	Homo sapiens	41-45
29200908-7	2017	In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p&lt;0.05).	ursolic acid	13-15	natriuretic peptide B	Homo sapiens	60-63
28756460-0	2017	Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats.	ursolic acid	0-12	G protein-coupled bile acid receptor 1	Rattus norvegicus	27-31
28756460-0	2017	Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats.	ursolic acid	0-12	glucagon	Rattus norvegicus	52-57
28756460-5	2017	It is of special interest to determine the potential effect of ursolic acid on TGR5.	ursolic acid	63-75	G protein-coupled bile acid receptor 1	Rattus norvegicus	79-83
28756460-10	2017	Ursolic acid concentration dependently increased glucose uptake in CHO-K1 cells expressing TGR5.	ursolic acid	0-12	G protein-coupled bile acid receptor 1	Rattus norvegicus	91-95
28756460-11	2017	In NCI-H716 cells, ursolic acid induced a concentration-dependent elevation in GLP-1 secretion, which was inhibited by triamterene at the effective concentrations to block TGR5.	ursolic acid	19-31	glucagon like peptide 1 receptor	Homo sapiens	79-84
28756460-11	2017	In NCI-H716 cells, ursolic acid induced a concentration-dependent elevation in GLP-1 secretion, which was inhibited by triamterene at the effective concentrations to block TGR5.	ursolic acid	19-31	G protein-coupled bile acid receptor 1	Homo sapiens	172-176
28756460-12	2017	Ursolic acid also increased the plasma GLP-1 level via TGR5 activation, which was further characterized in vivo with type 1-like diabetic rats.	ursolic acid	0-12	glucagon	Rattus norvegicus	39-44
28756460-12	2017	Ursolic acid also increased the plasma GLP-1 level via TGR5 activation, which was further characterized in vivo with type 1-like diabetic rats.	ursolic acid	0-12	G protein-coupled bile acid receptor 1	Rattus norvegicus	55-59
28756460-13	2017	Moreover, ursolic acid is more effective than betulinic acid in reduction of hyperglycemia and increase of GLP-1 secretion.	ursolic acid	10-22	glucagon	Rattus norvegicus	107-112
28756460-14	2017	Therefore, we demonstrated that ursolic acid can activate TGR5, enhancing GLP-1 secretion in vitro and in vivo.	ursolic acid	32-44	G protein-coupled bile acid receptor 1	Rattus norvegicus	58-62
28756460-14	2017	Therefore, we demonstrated that ursolic acid can activate TGR5, enhancing GLP-1 secretion in vitro and in vivo.	ursolic acid	32-44	glucagon	Rattus norvegicus	74-79
28756460-15	2017	Therefore, ursolic acid is suitable for use in TGR5 activation.	ursolic acid	11-23	G protein-coupled bile acid receptor 1	Rattus norvegicus	47-51
29228621-0	2017	Synergism of ursolic acid and cisplatin promotes apoptosis and enhances growth inhibition of cervical cancer cells via suppressing NF-kappaB p65.	ursolic acid	13-25	nuclear factor kappa B subunit 1	Homo sapiens	131-140
29228621-0	2017	Synergism of ursolic acid and cisplatin promotes apoptosis and enhances growth inhibition of cervical cancer cells via suppressing NF-kappaB p65.	ursolic acid	13-25	RELA proto-oncogene, NF-kB subunit	Homo sapiens	141-144
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	32-34	BCL2 apoptosis regulator	Homo sapiens	61-66
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	32-34	RELA proto-oncogene, NF-kB subunit	Homo sapiens	71-84
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	32-34	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	32-34	caspase 3	Homo sapiens	148-157
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	32-34	collagen type XI alpha 2 chain	Homo sapiens	162-166
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	93-95	BCL2 apoptosis regulator	Homo sapiens	61-66
29228621-9	2017	Compared with the DDP group and UA group, the expressions of Bcl-2 and NF-kappaB p65 in DDP +UA group were decreased, while the expressions of Bax, Caspase-3 and PARP cleavage were observably increased.	ursolic acid	93-95	RELA proto-oncogene, NF-kB subunit	Homo sapiens	71-84
29228621-10	2017	The expression of nuclear NF-kappaB p65 significantly reduced in UA group and DDP +UA group.	ursolic acid	65-67	nuclear factor kappa B subunit 1	Homo sapiens	26-35
29228621-10	2017	The expression of nuclear NF-kappaB p65 significantly reduced in UA group and DDP +UA group.	ursolic acid	65-67	RELA proto-oncogene, NF-kB subunit	Homo sapiens	36-39
29228621-10	2017	The expression of nuclear NF-kappaB p65 significantly reduced in UA group and DDP +UA group.	ursolic acid	83-85	nuclear factor kappa B subunit 1	Homo sapiens	26-35
29228621-10	2017	The expression of nuclear NF-kappaB p65 significantly reduced in UA group and DDP +UA group.	ursolic acid	83-85	RELA proto-oncogene, NF-kB subunit	Homo sapiens	36-39
29035547-9	2017	In a lipopolysaccharide (LPS)-induced acute inflammation model, UA inhibited LPS-stimulated iNos expression and that of the epigenetic markers the DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in leukocytes.	ursolic acid	64-66	nitric oxide synthase 2	Rattus norvegicus	92-96
29077044-7	2017	Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b1, tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified.	ursolic acid	69-81	kallikrein related peptidase 5	Homo sapiens	164-168
29077044-7	2017	Screening assays for evaluating the anti-KLK5 activity revealed that ursolic acid, oleanolic acid, saikosaponin b1, tumulosic acid and pachymic acid suppressed the KLK5 protease activity, although critical molecular moieties contributing to anti-KLK5 activity were unclarified.	ursolic acid	69-81	kallikrein related peptidase 5	Homo sapiens	164-168
29077044-8	2017	Ursolic acid and tumulosic acid suppressed the proteolytic processing of LL-37 in keratinocytes at &lt;=10 muM; no cytotoxicity was observed.	ursolic acid	0-12	cathelicidin antimicrobial peptide	Homo sapiens	73-78
29077044-8	2017	Ursolic acid and tumulosic acid suppressed the proteolytic processing of LL-37 in keratinocytes at &lt;=10 muM; no cytotoxicity was observed.	ursolic acid	0-12	latexin	Homo sapiens	107-110
29077044-10	2017	Our study reveals that triterpenoids, such as ursolic acid and tumulosic acid, modulate the KLK5 protease activity and cathelicidin peptide production.	ursolic acid	46-58	kallikrein related peptidase 5	Homo sapiens	92-96
29190954-0	2017	Cyclooxygenase-2 mediated synergistic effect of ursolic acid in combination with paclitaxel against human gastric carcinoma.	ursolic acid	48-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
28847726-8	2017	Pretreatment with ursolic acid (0.12 muM) increased the mitochondrial coupling efficiency of intact cells by 4.1 +- 1.1% relative to vehicle (p &lt; 0.008) and attenuated the effect of curcumin when the two compounds were used in combination.	ursolic acid	18-30	latexin	Homo sapiens	37-40
29190954-1	2017	Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2).	ursolic acid	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-90
29190954-1	2017	Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2).	ursolic acid	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97
29190954-1	2017	Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2).	ursolic acid	14-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-90
29190954-1	2017	Ursolic acid (UA) induces apoptosis in gastric cancer cells by inhibiting cyclooxygenase-2 (COX-2).	ursolic acid	14-16	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97
29190954-7	2017	Combined delivery of UA and PTX synergistically reduced cell proliferation and induced apoptosis in these cells by lowering COX-2, PCNA, and Bcl-2 expression and by increasing Bax expression.	ursolic acid	21-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	124-129
29190954-7	2017	Combined delivery of UA and PTX synergistically reduced cell proliferation and induced apoptosis in these cells by lowering COX-2, PCNA, and Bcl-2 expression and by increasing Bax expression.	ursolic acid	21-23	proliferating cell nuclear antigen	Homo sapiens	131-135
29190954-7	2017	Combined delivery of UA and PTX synergistically reduced cell proliferation and induced apoptosis in these cells by lowering COX-2, PCNA, and Bcl-2 expression and by increasing Bax expression.	ursolic acid	21-23	BCL2 apoptosis regulator	Homo sapiens	141-146
29190954-7	2017	Combined delivery of UA and PTX synergistically reduced cell proliferation and induced apoptosis in these cells by lowering COX-2, PCNA, and Bcl-2 expression and by increasing Bax expression.	ursolic acid	21-23	BCL2 associated X, apoptosis regulator	Homo sapiens	176-179
29190954-8	2017	These results indicate that the synergistic inhibition of proliferation and induction of apoptosis by UA and PTX may be induced by reducing COX-2 expression in gastric cancer cells.	ursolic acid	102-104	prostaglandin-endoperoxide synthase 2	Homo sapiens	140-145
29042951-0	2017	Ursolic acid suppresses TGF-beta1-induced quiescent HSC activation and transformation by inhibiting NADPH oxidase expression and Hedgehog signaling.	ursolic acid	0-12	transforming growth factor, beta 1	Rattus norvegicus	24-33
29042957-0	2017	Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-kappaB signaling pathways in vitro.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	158-161
29042951-11	2017	Pretreatment of q-HSCs with UA or DPI prior to TGF-beta1 significantly downregulated expression of NOX subunits and Hh signaling components and additionally inhibited expression of alpha-SMA and type I collagen, thereby preventing transformation to MFBs.	ursolic acid	28-30	actin gamma 2, smooth muscle	Rattus norvegicus	181-190
29042957-11	2017	To the best of our knowledge, the present study is the first to assess the effect of ursolic acid on breast cancer cells through PI3K/AKT-regulated GSK and caspase-3 accompanied by NF-kappaB signaling pathways.	ursolic acid	85-97	AKT serine/threonine kinase 1	Homo sapiens	134-137
29042957-11	2017	To the best of our knowledge, the present study is the first to assess the effect of ursolic acid on breast cancer cells through PI3K/AKT-regulated GSK and caspase-3 accompanied by NF-kappaB signaling pathways.	ursolic acid	85-97	caspase 3	Homo sapiens	156-165
29042951-12	2017	UA inhibited TGF-beta1-induced activation of q-HSCs and their transformation by inhibiting expression of NOX subunits and the downstream Hh pathway.	ursolic acid	0-2	transforming growth factor, beta 1	Rattus norvegicus	13-22
28663034-10	2017	Akt phosphorylation/activation in cells was also diminished by UA.	ursolic acid	63-65	AKT serine/threonine kinase 1	Rattus norvegicus	0-3
28598231-5	2017	Ursolic acid administration leads to transient remission of metabolic syndrome, reducing body weight, BMI, waist circumference and fasting glucose, as well as increasing insulin sensitivity.	ursolic acid	0-12	insulin	Homo sapiens	170-177
27600106-0	2017	In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug-drug interaction risk prediction.	ursolic acid	41-53	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	23-29
28766764-4	2017	The antiproliferative testing against HL-60 cells revealed that the new compound 1 and ursolic acid (5) showed weak and moderate activities with IC50 values of 42.2 and 11.7 muM.	ursolic acid	87-99	latexin	Homo sapiens	174-177
27600106-0	2017	In vitro inhibition of UGT1A3, UGT1A4 by ursolic acid and oleanolic acid and drug-drug interaction risk prediction.	ursolic acid	41-53	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	31-37
27600106-8	2017	UA-mediated inhibition of UGT1A3 catalyzed 4-MU-beta-d-glucuronidation was via competitive inhibition (IC50 0.391 +- 0.013 muM; Ki 0.185 +- 0.015 muM).	ursolic acid	0-2	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	26-32
27600106-9	2017	UA also competitively inhibited UGT1A4-mediated trifluoperazine-N-glucuronidation (IC50 2.651 +- 0.201 muM; Ki 1.334 +- 0.146 muM).	ursolic acid	0-2	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	32-38
28771340-2	2017	Hence, a targeted drug delivery system (UA/siVEGF@MSN-FA) coloading ursolic acid (UA) and vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) based on mesoporous silica (MSN) nanocarrier modified by a folic acid (FA) molecule was designed and synthesized.	ursolic acid	68-80	moesin	Homo sapiens	50-53
28771340-6	2017	Our findings demonstrated that UA@MSN-FA nanoparticles were near-spherical, and the particle size was about 209 +- 9.21 nm.	ursolic acid	31-33	moesin	Homo sapiens	34-37
28771340-2	2017	Hence, a targeted drug delivery system (UA/siVEGF@MSN-FA) coloading ursolic acid (UA) and vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) based on mesoporous silica (MSN) nanocarrier modified by a folic acid (FA) molecule was designed and synthesized.	ursolic acid	68-80	vascular endothelial growth factor A	Homo sapiens	45-49
28771340-2	2017	Hence, a targeted drug delivery system (UA/siVEGF@MSN-FA) coloading ursolic acid (UA) and vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) based on mesoporous silica (MSN) nanocarrier modified by a folic acid (FA) molecule was designed and synthesized.	ursolic acid	40-42	vascular endothelial growth factor A	Homo sapiens	90-124
28766112-0	2017	Oleanolic acid and ursolic acid as potential inhibitors of human salivary alpha-amylase: insights from in vitro assays and in silico simulations.	ursolic acid	19-31	amylase alpha 1A	Homo sapiens	65-87
28714512-0	2017	Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma.	ursolic acid	41-53	signal transducer and activator of transcription 3	Homo sapiens	14-19
28714512-4	2017	However, whether UA could inhibit STAT3 phosphorylation in hepatocellular carcinoma has not been reported.	ursolic acid	17-19	signal transducer and activator of transcription 3	Homo sapiens	34-39
28714512-5	2017	The inhibitory effects of UA on STAT3 phosphorylation, along with cell viability, migration, colony formation in vitro, as well as tumor growth in vivo were examined in human liver cancer cell lines.	ursolic acid	26-28	signal transducer and activator of transcription 3	Homo sapiens	32-37
28714512-6	2017	Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3.	ursolic acid	21-23	signal transducer and activator of transcription 3	Homo sapiens	40-45
28714512-6	2017	Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3.	ursolic acid	21-23	interleukin 6	Homo sapiens	57-70
28714512-6	2017	Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3.	ursolic acid	21-23	interleukin 6	Homo sapiens	72-76
28714512-6	2017	Our data showed that UA inhibited the P-STAT3 induced by interleukin-6 (IL-6) in Hep3B liver cancer cells which express very low basal level of P-STAT3.	ursolic acid	21-23	signal transducer and activator of transcription 3	Homo sapiens	146-151
28714512-7	2017	The constitutive STAT3 phosphorylation was also inhibited by UA in HEPG2, 7721 and Huh7 human liver cancer cell lines.	ursolic acid	61-63	signal transducer and activator of transcription 3	Homo sapiens	17-22
28714512-8	2017	UA decreased the expression of downstream target genes of STAT3, such as Bcl-2, Bcl-xl and survivin in general, with difference in these cell lines.	ursolic acid	0-2	signal transducer and activator of transcription 3	Homo sapiens	58-63
28714512-8	2017	UA decreased the expression of downstream target genes of STAT3, such as Bcl-2, Bcl-xl and survivin in general, with difference in these cell lines.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	73-78
28714512-8	2017	UA decreased the expression of downstream target genes of STAT3, such as Bcl-2, Bcl-xl and survivin in general, with difference in these cell lines.	ursolic acid	0-2	BCL2 like 1	Homo sapiens	80-86
28714512-11	2017	UA, which exists widely in fruits and herbs, could inhibit STAT3 activation and the growth of human liver cancer cells in vitro and in vivo.	ursolic acid	0-2	signal transducer and activator of transcription 3	Homo sapiens	59-64
28766112-4	2017	Our in vitro inhibition studies demonstrated that oleanolic acid and ursolic acid non-competitively inhibit the activity and function of human salivary alpha-amylase.	ursolic acid	69-81	amylase alpha 1A	Homo sapiens	143-165
28766112-5	2017	The molecular simulations revealed that oleanolic acid and ursolic acid interact with amino acid residues within the binding pocket of human salivary alpha-amylase, among which the side chain of Arg195 and Asp 197 was supposed to be important in imparting the inhibitory activity of triterpenoids.	ursolic acid	59-71	amylase alpha 1A	Homo sapiens	141-163
28177667-11	2017	In rat VSMCs, UA effectively inhibited cell growth and the activity of MMP2 induced by leptin.	ursolic acid	14-16	matrix metallopeptidase 2	Rattus norvegicus	71-75
26567247-12	2017	Our data suggest that UA inhibits miR-21 expression and increases PTEN expression, which in turn inhibits Akt and mTOR and restores normal levels of autophagy.	ursolic acid	22-24	microRNA 21a	Mus musculus	34-40
26567247-12	2017	Our data suggest that UA inhibits miR-21 expression and increases PTEN expression, which in turn inhibits Akt and mTOR and restores normal levels of autophagy.	ursolic acid	22-24	phosphatase and tensin homolog	Mus musculus	66-70
26567247-12	2017	Our data suggest that UA inhibits miR-21 expression and increases PTEN expression, which in turn inhibits Akt and mTOR and restores normal levels of autophagy.	ursolic acid	22-24	thymoma viral proto-oncogene 1	Mus musculus	106-109
26567247-12	2017	Our data suggest that UA inhibits miR-21 expression and increases PTEN expression, which in turn inhibits Akt and mTOR and restores normal levels of autophagy.	ursolic acid	22-24	mechanistic target of rapamycin kinase	Mus musculus	114-118
26567247-13	2017	Conclusions: Our data suggest that podocyte injury is associated with reduced levels of autophagy during exposure to high glucose conditions, UA attenuated podocyte injury via an increase in autophagy through miR-21 inhibition and PTEN expression, which inhibit the abnormal activation of the PI3K/Akt/mTOR pathway.	ursolic acid	142-144	microRNA 21a	Mus musculus	209-215
26567247-13	2017	Conclusions: Our data suggest that podocyte injury is associated with reduced levels of autophagy during exposure to high glucose conditions, UA attenuated podocyte injury via an increase in autophagy through miR-21 inhibition and PTEN expression, which inhibit the abnormal activation of the PI3K/Akt/mTOR pathway.	ursolic acid	142-144	phosphatase and tensin homolog	Mus musculus	231-235
26567247-13	2017	Conclusions: Our data suggest that podocyte injury is associated with reduced levels of autophagy during exposure to high glucose conditions, UA attenuated podocyte injury via an increase in autophagy through miR-21 inhibition and PTEN expression, which inhibit the abnormal activation of the PI3K/Akt/mTOR pathway.	ursolic acid	142-144	thymoma viral proto-oncogene 1	Mus musculus	298-301
26567247-13	2017	Conclusions: Our data suggest that podocyte injury is associated with reduced levels of autophagy during exposure to high glucose conditions, UA attenuated podocyte injury via an increase in autophagy through miR-21 inhibition and PTEN expression, which inhibit the abnormal activation of the PI3K/Akt/mTOR pathway.	ursolic acid	142-144	mechanistic target of rapamycin kinase	Mus musculus	302-306
28675237-0	2017	Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance.	ursolic acid	0-12	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	72-76
28675237-0	2017	Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance.	ursolic acid	0-12	PPARG coactivator 1 alpha	Homo sapiens	81-86
28675237-8	2017	Our findings suggest that UA may induce mitochondrial biogenesis through the activation of AMPK and PGC-1 pathways in skeletal muscle, thereby offering a promising prospect for its use to enhance exercise endurance and alleviating fatigue in humans.	ursolic acid	26-28	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	91-95
28675237-8	2017	Our findings suggest that UA may induce mitochondrial biogenesis through the activation of AMPK and PGC-1 pathways in skeletal muscle, thereby offering a promising prospect for its use to enhance exercise endurance and alleviating fatigue in humans.	ursolic acid	26-28	PPARG coactivator 1 alpha	Homo sapiens	100-105
28660943-0	2017	A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	90-102	tumor protein p53	Homo sapiens	158-161
28660943-0	2017	A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	90-102	matrix metallopeptidase 9	Homo sapiens	162-167
28660943-0	2017	A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	90-102	phosphatase and tensin homolog	Homo sapiens	168-172
28660943-0	2017	A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways.	ursolic acid	90-102	CD44 molecule (Indian blood group)	Homo sapiens	173-177
28660943-7	2017	Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53.	ursolic acid	17-19	collagen type XI alpha 2 chain	Homo sapiens	139-143
28660943-7	2017	Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53.	ursolic acid	17-19	BCL2 apoptosis regulator	Homo sapiens	144-149
28660943-7	2017	Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53.	ursolic acid	17-19	matrix metallopeptidase 9	Homo sapiens	150-155
28660943-7	2017	Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53.	ursolic acid	17-19	CD44 molecule (Indian blood group)	Homo sapiens	156-160
28660943-7	2017	Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53.	ursolic acid	17-19	phosphatase and tensin homolog	Homo sapiens	161-165
28660943-7	2017	Mechanistically, UA@M-CS-FA induced cancer cell apoptosis and inhibited migration via cell cycle arrest in the G0/G1 stage, regulating the PARP/Bcl-2/MMP-9/CD44/PTEN/P53.	ursolic acid	17-19	tumor protein p53	Homo sapiens	166-169
28660943-9	2017	Immunohistochemical analysis revealed that UA@M-CS-FA treatment regulated CD44, a biomarker of cancer metastasis.	ursolic acid	43-45	CD44 molecule (Indian blood group)	Homo sapiens	74-78
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	ursolic acid	49-61	Wnt family member 2	Rattus norvegicus	179-182
28493531-3	2017	Comparison of a binary complex of nonliganded (apo) RORgamma-LBD with a nuclear receptor co-activator (NCoA-1) peptide has shown that our inhibitor displays a unique mechanism different from those caused by natural inhibitor, ursolic acid (UA).	ursolic acid	226-238	nuclear receptor coactivator 1	Homo sapiens	103-109
28493531-3	2017	Comparison of a binary complex of nonliganded (apo) RORgamma-LBD with a nuclear receptor co-activator (NCoA-1) peptide has shown that our inhibitor displays a unique mechanism different from those caused by natural inhibitor, ursolic acid (UA).	ursolic acid	240-242	nuclear receptor coactivator 1	Homo sapiens	103-109
27461151-5	2017	Galangin, puerarin, and ursolic acid (10, 100, 500, 1000, 2000, 5000, 10 000, and 20 000 muM) were found to have antioxidant activities at the studied concentrations.	ursolic acid	24-36	latexin	Homo sapiens	89-92
27461151-6	2017	IC50 values of galangin, puerarin, and ursolic acid in V79 cells were found to be 275.48 muM, 2503.712 muM, and 224.85 muM, respectively.	ursolic acid	39-51	latexin	Homo sapiens	89-92
27461151-6	2017	IC50 values of galangin, puerarin, and ursolic acid in V79 cells were found to be 275.48 muM, 2503.712 muM, and 224.85 muM, respectively.	ursolic acid	39-51	latexin	Homo sapiens	103-106
27461151-6	2017	IC50 values of galangin, puerarin, and ursolic acid in V79 cells were found to be 275.48 muM, 2503.712 muM, and 224.85 muM, respectively.	ursolic acid	39-51	latexin	Homo sapiens	103-106
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	ursolic acid	83-95	carboxylesterase 1	Homo sapiens	146-150
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	ursolic acid	83-95	carboxylesterase 2	Homo sapiens	186-190
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	ursolic acid	97-99	carboxylesterase 1	Homo sapiens	146-150
28713276-4	2017	Following screening of a series of natural triterpenoids, oleanolic acid (OA), and ursolic acid (UA) were found with strong inhibitory effects on hCE1 and relative high selectivity over hCE2.	ursolic acid	97-99	carboxylesterase 2	Homo sapiens	186-190
28713276-8	2017	In contrast, the structural modifications on OA and UA at other sites, such as converting the C-3 hydroxy group to 3-O-beta-carboxypropionyl (compounds 20 and 22), led to a dramatically increase of the inhibitory effects against hCE1 and very high selectivity over hCE2.	ursolic acid	52-54	carboxylesterase 1	Homo sapiens	229-233
28713276-8	2017	In contrast, the structural modifications on OA and UA at other sites, such as converting the C-3 hydroxy group to 3-O-beta-carboxypropionyl (compounds 20 and 22), led to a dramatically increase of the inhibitory effects against hCE1 and very high selectivity over hCE2.	ursolic acid	52-54	carboxylesterase 2	Homo sapiens	265-269
28670276-5	2017	In addition, UA also reversed gamma irradiation induced inflammatory responses, as indicated by the decreased production of TNF-alpha, IL-6, and IL-1beta.	ursolic acid	13-15	tumor necrosis factor	Mus musculus	124-133
28670276-5	2017	In addition, UA also reversed gamma irradiation induced inflammatory responses, as indicated by the decreased production of TNF-alpha, IL-6, and IL-1beta.	ursolic acid	13-15	interleukin 6	Mus musculus	135-139
28670276-5	2017	In addition, UA also reversed gamma irradiation induced inflammatory responses, as indicated by the decreased production of TNF-alpha, IL-6, and IL-1beta.	ursolic acid	13-15	interleukin 1 beta	Mus musculus	145-153
28670276-7	2017	Our results further demonstrated that gamma radiation dose- and time-dependently enhanced NF-kappaB DNA binding activity, which was significantly attenuated upon UA treatment.	ursolic acid	162-164	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
28213701-6	2017	UA (20 microM) also diminished AKT signaling that affected glycolysis as judged by decreased levels of HK2, PKM2, ATP and lactate.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	31-34
28213701-6	2017	UA (20 microM) also diminished AKT signaling that affected glycolysis as judged by decreased levels of HK2, PKM2, ATP and lactate.	ursolic acid	0-2	hexokinase 2	Homo sapiens	103-106
28213701-6	2017	UA (20 microM) also diminished AKT signaling that affected glycolysis as judged by decreased levels of HK2, PKM2, ATP and lactate.	ursolic acid	0-2	pyruvate kinase M1/2	Homo sapiens	108-112
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	ursolic acid	49-61	catenin beta 1	Rattus norvegicus	183-195
28343085-6	2017	Out of six abundantly present triterpenes in GE, ursolic acid (UA) and 2alpha-hydroxy ursolic acid (2alpha-UA) induced osteogenic differentiation in vitro as did GE by activating Wnt/beta-catenin pathway assessed by phosphorylation of GSK-3beta.	ursolic acid	49-61	glycogen synthase kinase 3 beta	Rattus norvegicus	235-244
28288941-0	2017	Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid.	ursolic acid	75-87	nuclear receptor subfamily 1 group I member 2	Homo sapiens	27-46
28288941-2	2017	In the present study, we determined whether carnosic acid and other chemicals in rosemary extract (carnosol, ursolic acid, and rosmarinic acid) are PXR activators.	ursolic acid	109-121	nuclear receptor subfamily 1 group I member 2	Homo sapiens	148-151
28288941-4	2017	Dose-response experiments indicated that carnosic acid, carnosol, and ursolic acid activated hPXR with EC50 values of 0.79, 2.22, and 10.77muM, respectively.	ursolic acid	70-82	nuclear receptor subfamily 1 group I member 2	Homo sapiens	93-97
28288941-3	2017	As assessed in dual-luciferase reporter gene assays, carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, activated human PXR (hPXR) and mouse PXR (mPXR), whereas carnosol and ursolic acid, but not carnosic acid or rosmarinic acid, activated rat PXR (rPXR).	ursolic acid	82-94	nuclear receptor subfamily 1 group I member 2	Homo sapiens	137-140
28288941-5	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, transactivated the ligand-binding domain of hPXR and recruited steroid receptor coactivator-1 (SRC-1), SRC-2, and SRC-3 to the ligand-binding domain of hPXR.	ursolic acid	29-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	112-116
28288941-5	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, transactivated the ligand-binding domain of hPXR and recruited steroid receptor coactivator-1 (SRC-1), SRC-2, and SRC-3 to the ligand-binding domain of hPXR.	ursolic acid	29-41	nuclear receptor coactivator 1	Homo sapiens	131-161
28288941-3	2017	As assessed in dual-luciferase reporter gene assays, carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, activated human PXR (hPXR) and mouse PXR (mPXR), whereas carnosol and ursolic acid, but not carnosic acid or rosmarinic acid, activated rat PXR (rPXR).	ursolic acid	82-94	nuclear receptor subfamily 1 group I member 2	Homo sapiens	142-146
28288941-5	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, transactivated the ligand-binding domain of hPXR and recruited steroid receptor coactivator-1 (SRC-1), SRC-2, and SRC-3 to the ligand-binding domain of hPXR.	ursolic acid	29-41	nuclear receptor coactivator 1	Homo sapiens	163-168
28288941-3	2017	As assessed in dual-luciferase reporter gene assays, carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, activated human PXR (hPXR) and mouse PXR (mPXR), whereas carnosol and ursolic acid, but not carnosic acid or rosmarinic acid, activated rat PXR (rPXR).	ursolic acid	82-94	nuclear receptor subfamily 1, group I, member 2	Mus musculus	143-146
28288941-5	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, transactivated the ligand-binding domain of hPXR and recruited steroid receptor coactivator-1 (SRC-1), SRC-2, and SRC-3 to the ligand-binding domain of hPXR.	ursolic acid	29-41	nuclear receptor coactivator 2	Homo sapiens	171-176
28288941-3	2017	As assessed in dual-luciferase reporter gene assays, carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, activated human PXR (hPXR) and mouse PXR (mPXR), whereas carnosol and ursolic acid, but not carnosic acid or rosmarinic acid, activated rat PXR (rPXR).	ursolic acid	82-94	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	143-146
28288941-5	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, transactivated the ligand-binding domain of hPXR and recruited steroid receptor coactivator-1 (SRC-1), SRC-2, and SRC-3 to the ligand-binding domain of hPXR.	ursolic acid	29-41	nuclear receptor coactivator 3	Homo sapiens	182-187
28347799-0	2017	Ursolic acid attenuates cigarette smoke-induced emphysema in rats by regulating PERK and Nrf2 pathways.	ursolic acid	0-12	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93
28288941-5	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, transactivated the ligand-binding domain of hPXR and recruited steroid receptor coactivator-1 (SRC-1), SRC-2, and SRC-3 to the ligand-binding domain of hPXR.	ursolic acid	29-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	220-224
28288941-6	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, increased hPXR target gene expression, as shown by an increase in CYP3A4, UGT1A3, and ABCB1 mRNA expression in LS180 human colon adenocarcinoma cells.	ursolic acid	29-41	nuclear receptor subfamily 1 group I member 2	Homo sapiens	78-82
28288941-6	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, increased hPXR target gene expression, as shown by an increase in CYP3A4, UGT1A3, and ABCB1 mRNA expression in LS180 human colon adenocarcinoma cells.	ursolic acid	29-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	134-140
28288941-6	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, increased hPXR target gene expression, as shown by an increase in CYP3A4, UGT1A3, and ABCB1 mRNA expression in LS180 human colon adenocarcinoma cells.	ursolic acid	29-41	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	142-148
28288941-6	2017	Carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, increased hPXR target gene expression, as shown by an increase in CYP3A4, UGT1A3, and ABCB1 mRNA expression in LS180 human colon adenocarcinoma cells.	ursolic acid	29-41	ATP binding cassette subfamily B member 1	Homo sapiens	154-159
28288941-8	2017	Overall, carnosic acid, carnosol, and ursolic acid, but not rosmarinic acid, are hPXR agonists, and carnosic acid shows species-dependent activation of hPXR and mPXR, but not rPXR.	ursolic acid	38-50	nuclear receptor subfamily 1 group I member 2	Homo sapiens	81-85
28288941-9	2017	The findings provide new mechanistic insight on the effects of carnosic acid, carnosol, and ursolic acid on PXR-mediated biological effects.	ursolic acid	92-104	nuclear receptor subfamily 1 group I member 2	Homo sapiens	108-111
28347799-11	2017	Compared with CS group, UA treatment down-regulated PERK pathway protein expression, up-regulated expression of Bcl-2 and down-regulated expression of Bax, Cleaved-Caspase3 and Cleaved-Caspase12.	ursolic acid	24-26	BCL2, apoptosis regulator	Rattus norvegicus	112-117
28347799-11	2017	Compared with CS group, UA treatment down-regulated PERK pathway protein expression, up-regulated expression of Bcl-2 and down-regulated expression of Bax, Cleaved-Caspase3 and Cleaved-Caspase12.	ursolic acid	24-26	BCL2 associated X, apoptosis regulator	Rattus norvegicus	151-154
28347799-11	2017	Compared with CS group, UA treatment down-regulated PERK pathway protein expression, up-regulated expression of Bcl-2 and down-regulated expression of Bax, Cleaved-Caspase3 and Cleaved-Caspase12.	ursolic acid	24-26	caspase 12	Rattus norvegicus	185-194
28347799-13	2017	UA also up-regulated protein expression of Nrf2/ARE pathway and GSH level, decreased expression of oxidant stress factor 8-OHdG and MDA.	ursolic acid	0-2	NFE2 like bZIP transcription factor 2	Rattus norvegicus	43-47
28347799-15	2017	CONCLUSIONS: UA attenuates CS-induced rat emphysema by down-regulating PERK pathway to alleviate CS-induced apoptosis in lung, and up-regulating Nrf2 pathway to improve cigarette smoke-induced oxidant stress in rat lungs.	ursolic acid	13-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	145-149
30108853-0	2017	Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-kappaB) pathway and cell proliferation.	ursolic acid	42-54	nuclear factor kappa B subunit 1	Homo sapiens	116-138
30108853-6	2017	Thus, the rational design of UA derivatives with functionalized aniline or amide side chains offers significant potential for the discovery of a new class of NF-kappaB inhibitors with the ability to induce apoptosis and reverse multidrug resistance in the NCI-H460 lung adenocarcinoma cell line.	ursolic acid	29-31	nuclear factor kappa B subunit 1	Homo sapiens	158-167
30108853-0	2017	Side chain-functionalized aniline-derived ursolic acid derivatives as multidrug resistance reversers that block the nuclear factor-kappa B (NF-kappaB) pathway and cell proliferation.	ursolic acid	42-54	nuclear factor kappa B subunit 1	Homo sapiens	140-149
30108853-1	2017	A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing functionalized aniline or amide side chains were synthesized and evaluated for inhibition of NF-kappaB as well as their antitumor effects.	ursolic acid	45-57	nuclear factor kappa B subunit 1	Homo sapiens	26-35
30108853-1	2017	A series of inhibitors of NF-kappaB based on ursolic acid (UA) derivatives containing functionalized aniline or amide side chains were synthesized and evaluated for inhibition of NF-kappaB as well as their antitumor effects.	ursolic acid	59-61	nuclear factor kappa B subunit 1	Homo sapiens	26-35
28338932-0	2017	Ursolic acid derivative FZU-03,010 inhibits STAT3 and induces cell cycle arrest and apoptosis in renal and breast cancer cells.	ursolic acid	0-12	signal transducer and activator of transcription 3	Homo sapiens	44-49
28259944-10	2017	Data indicated that ursolic acid nanoparticles, indeed, significantly suppress cervial cancer cell proliferation, invasion and migration compared to the control group, and apoptosis was induced by ursolic acid nanoparticles in cervical cancer cells through activating caspases, p53 and suppressing anti-apoptosis-related signals.	ursolic acid	20-32	tumor protein p53	Homo sapiens	278-281
27984757-9	2017	Animals treated with UA had less parasites in the spleen and liver when compared with the infected control group, and they also showed preservation of white and red pulps, which correlate with a high rate of proliferation of splenic mononuclear cells, IFN-gamma mRNA and iNOS production.	ursolic acid	21-23	interferon gamma	Homo sapiens	252-261
28259944-10	2017	Data indicated that ursolic acid nanoparticles, indeed, significantly suppress cervial cancer cell proliferation, invasion and migration compared to the control group, and apoptosis was induced by ursolic acid nanoparticles in cervical cancer cells through activating caspases, p53 and suppressing anti-apoptosis-related signals.	ursolic acid	197-209	tumor protein p53	Homo sapiens	278-281
27897418-5	2017	Results from promoter and ChIP assays demonstrated a mechanism involving ursolic acid blockade of myostatin promoter activity that is related to CEBP/delta expression.	ursolic acid	73-85	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	145-149
28264698-6	2017	Ursolic acid had the most potent cytotoxicity against THP-1 and RAW 264.7 cells with LC50 values of 9.62 and 4.56 mug/mL respectively, and selectivity index values of 7.32 and 15.44 respectively.	ursolic acid	0-12	GLI family zinc finger 2	Homo sapiens	54-59
28358057-0	2017	Synthesis and biological evaluation of novel ursolic acid analogues as potential alpha-glucosidase inhibitors.	ursolic acid	45-57	sucrase-isomaltase	Homo sapiens	81-98
27776314-1	2017	The binding properties of pentacyclic triterpenoid isomeric drugs, i.e. ursolic acid (UA) and oleanolic acid (OA), to bovine lactoferrin (BLF) have been studied by molecule modeling, fluorescence spectroscopy, UV-visible absorbance spectroscopy and infrared spectroscopy (IR).	ursolic acid	72-84	lactotransferrin	Bos taurus	125-136
27776314-1	2017	The binding properties of pentacyclic triterpenoid isomeric drugs, i.e. ursolic acid (UA) and oleanolic acid (OA), to bovine lactoferrin (BLF) have been studied by molecule modeling, fluorescence spectroscopy, UV-visible absorbance spectroscopy and infrared spectroscopy (IR).	ursolic acid	86-88	lactotransferrin	Bos taurus	125-136
28356955-0	2017	Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-72
27734181-10	2017	Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway.	ursolic acid	101-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	162-166
27734181-12	2017	These data indicated that UA increases the activity of antioxidant enzymes and attenuated brain injury via Nrf2 factor.	ursolic acid	26-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
27734181-0	2017	Ursolic Acid Ameliorates Early Brain Injury After Experimental Traumatic Brain Injury in Mice by Activating the Nrf2 Pathway.	ursolic acid	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
27734181-2	2017	Ursolic acid (UA) has been demonstrated to exert anti-oxidative and anti-inflammatory effects on cerebral ischemia by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway.	ursolic acid	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	133-176
27734181-2	2017	Ursolic acid (UA) has been demonstrated to exert anti-oxidative and anti-inflammatory effects on cerebral ischemia by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway.	ursolic acid	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
27734181-2	2017	Ursolic acid (UA) has been demonstrated to exert anti-oxidative and anti-inflammatory effects on cerebral ischemia by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway.	ursolic acid	14-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	133-176
27734181-2	2017	Ursolic acid (UA) has been demonstrated to exert anti-oxidative and anti-inflammatory effects on cerebral ischemia by activating the nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway.	ursolic acid	14-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	178-182
27734181-4	2017	The aim of this study is to evaluate the potential roles of UA in the activation of the Nrf2 pathway using an experimental TBI model and the underlying mechanism.	ursolic acid	60-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
27734181-9	2017	In addition, UA treatment markedly strengthened the nuclear translocation of Nrf2 protein and increased the expression of NQO1 and HO1.	ursolic acid	13-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	77-81
27734181-9	2017	In addition, UA treatment markedly strengthened the nuclear translocation of Nrf2 protein and increased the expression of NQO1 and HO1.	ursolic acid	13-15	NAD(P)H dehydrogenase, quinone 1	Mus musculus	122-126
27734181-9	2017	In addition, UA treatment markedly strengthened the nuclear translocation of Nrf2 protein and increased the expression of NQO1 and HO1.	ursolic acid	13-15	heme oxygenase 1	Mus musculus	131-134
27734181-10	2017	Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway.	ursolic acid	10-12	thymoma viral proto-oncogene 1	Mus musculus	55-58
27734181-10	2017	Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway.	ursolic acid	10-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
27734181-10	2017	Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway.	ursolic acid	10-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	162-166
27734181-10	2017	Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway.	ursolic acid	101-103	thymoma viral proto-oncogene 1	Mus musculus	55-58
27734181-10	2017	Moreover, UA significantly increased the expression of AKT, an Nrf2 upstream factor, suggesting that UA play a neuroprotective role through the activation of the Nrf2-ARE signal pathway.	ursolic acid	101-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
28356955-0	2017	Ursolic acid sensitizes radioresistant NSCLC cells expressing HIF-1alpha through reducing endogenous GSH and inhibiting HIF-1alpha.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	120-130
28356955-6	2017	The irradiated H1299/M-HIF-1alpha cells were more sensitive to UA pretreatment than the irradiated cells with empty plasmid and control.	ursolic acid	63-65	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
28356955-10	2017	The results revealed that UA treatment alone could effectively decrease the GSH content in H1299/M-HIF-1alpha cells.	ursolic acid	26-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
28356955-12	2017	It was then concluded that UA could upregulate the radiosensitivity of NSCLC cells, and in particular reduce the refractory response of cells expressing HIF-1alpha to ionizing radiation.	ursolic acid	27-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	153-163
27665868-0	2016	Ursolic acid inhibits proliferation and induces apoptosis by inactivating Wnt/beta-catenin signaling in human osteosarcoma cells.	ursolic acid	0-12	catenin beta 1	Homo sapiens	78-90
27750148-6	2017	Molecular dynamics simulations illustrated that the more stable hydrogen bond interaction of the UA derivative 12e with Ser191 and stronger hydrophobic interactions with Val198, Phe463 than those of OA derivative 12b mainly led to their significantly different CETP inhibitory activity.	ursolic acid	97-99	cholesteryl ester transfer protein	Homo sapiens	261-265
28854432-10	2017	Compared with control group, Bax decreased and Bcl-2 increased in UA-treated group.	ursolic acid	66-68	apoptosis regulator BAX	Sus scrofa	29-32
28854432-10	2017	Compared with control group, Bax decreased and Bcl-2 increased in UA-treated group.	ursolic acid	66-68	apoptosis regulator Bcl-2	Sus scrofa	47-52
27773812-0	2016	3beta-Hydroxy-urs-12-en-28-oic acid prolongs lifespan in C. elegans by modulating JNK-1.	ursolic acid	0-35	Stress-activated protein kinase jnk-1	Caenorhabditis elegans	82-87
27769622-0	2016	Discovery of ursolic acid prodrug (NX-201): Pharmacokinetics and in vivo antitumor effects in PANC-1 pancreatic cancer.	ursolic acid	13-25	pancreas protein 1	Mus musculus	94-100
27683033-0	2016	A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment.	ursolic acid	31-43	IL2 inducible T cell kinase	Homo sapiens	143-146
27683033-0	2016	A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment.	ursolic acid	31-43	epidermal growth factor receptor	Homo sapiens	151-155
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	150-153
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	cyclin D1	Homo sapiens	158-167
27665868-11	2016	Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/beta-catenin signaling, which may be mediated partly by upregulating the expression of p53.	ursolic acid	28-30	catenin beta 1	Homo sapiens	106-118
27665868-6	2016	Using a luciferase reporter assay, we found that the Wnt/beta-catenin signaling is inhibited by UA in 143B cells.	ursolic acid	96-98	catenin beta 1	Homo sapiens	57-69
27665868-11	2016	Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/beta-catenin signaling, which may be mediated partly by upregulating the expression of p53.	ursolic acid	28-30	tumor protein p53	Homo sapiens	193-196
27665868-8	2016	Exogenous expression of beta-catenin attenuates the anticancer effect of UA in 143B cells, while knockdown of beta-catenin enhances this effect.	ursolic acid	73-75	catenin beta 1	Homo sapiens	24-36
27665868-9	2016	UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells.	ursolic acid	0-2	tumor protein p53	Homo sapiens	37-40
27665868-9	2016	UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells.	ursolic acid	133-135	tumor protein p53	Homo sapiens	96-99
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	tumor protein p53	Homo sapiens	24-27
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	catenin beta 1	Homo sapiens	77-89
27665868-10	2016	Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1.	ursolic acid	48-50	catenin beta 1	Homo sapiens	116-128
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	ursolic acid	104-116	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	148-153
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	ursolic acid	104-116	acid phosphatase 5, tartrate resistant	Mus musculus	162-197
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	ursolic acid	104-116	acid phosphatase 5, tartrate resistant	Mus musculus	199-203
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	ursolic acid	118-120	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	148-153
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	ursolic acid	118-120	acid phosphatase 5, tartrate resistant	Mus musculus	162-197
27748884-4	2016	The present study demosntrated that FLL extract and its two primary components, oleanolic acid (OA) and ursolic acid (UA), significantly suppressed RANKL-induced tartrate resistant acid phosphatase (TRAP) activity and multinucleate osteoclast formation without inducing cytotoxicity; however, no effect was observed on the apoptosis of mature osteoclasts.	ursolic acid	118-120	acid phosphatase 5, tartrate resistant	Mus musculus	199-203
28090191-0	2016	Blockage of epithelial to mesenchymal transition and upregulation of let 7b are critically involved in ursolic acid induced apoptosis in malignant mesothelioma cell.	ursolic acid	103-115	microRNA let-7b	Homo sapiens	69-75
27708244-10	2016	Cancer cells were sensitive to UA treating after the silencing of HIF-1alpha and the response of Hypoxic pathway reporter to UA was suppressed when HIF-1alpha was over expressed.	ursolic acid	31-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	66-76
27708244-10	2016	Cancer cells were sensitive to UA treating after the silencing of HIF-1alpha and the response of Hypoxic pathway reporter to UA was suppressed when HIF-1alpha was over expressed.	ursolic acid	31-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	148-158
27822011-0	2016	Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway.	ursolic acid	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
28090191-4	2016	Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells.	ursolic acid	6-18	cyclin D1	Homo sapiens	106-115
28090191-4	2016	Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells.	ursolic acid	6-18	catenin beta 1	Homo sapiens	182-194
28090191-4	2016	Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells.	ursolic acid	6-18	poly(ADP-ribose) polymerase 1	Homo sapiens	278-328
28090191-4	2016	Also, ursolic acid treatment accumulated the sub-G1 population, attenuated the expression of procapase 9, cyclin D1, pAKT, p-glycogen synthase kinase 3-alpha/beta (pGSK3alpha/beta), beta-catenin and nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) and also cleaved caspase 3 and poly (ADP-ribose) polymerase (PARP) in mesothelioma cells.	ursolic acid	6-18	poly(ADP-ribose) polymerase 1	Homo sapiens	330-334
28090191-5	2016	Furthermore, ursolic acid treatment blocked epithelial and mesenchymal transition (EMT) molecules by activating E-cadherin as an epithelial marker and attenuating Vimentin, and Twist as mesenchymal molecules.	ursolic acid	13-25	cadherin 1	Homo sapiens	112-122
28090191-5	2016	Furthermore, ursolic acid treatment blocked epithelial and mesenchymal transition (EMT) molecules by activating E-cadherin as an epithelial marker and attenuating Vimentin, and Twist as mesenchymal molecules.	ursolic acid	13-25	vimentin	Homo sapiens	163-171
28090191-7	2016	Furthermore, overexpression of let 7b using let-7b mimics enhanced the antitumor effect of ursolic acid to attenuate the expression of procaspases 3, pro-PARP, pAKT, beta-catenin and Twist and increase sub-G1 accumulation in H2452 mesothelioma cells.	ursolic acid	91-103	microRNA let-7b	Homo sapiens	31-37
28090191-7	2016	Furthermore, overexpression of let 7b using let-7b mimics enhanced the antitumor effect of ursolic acid to attenuate the expression of procaspases 3, pro-PARP, pAKT, beta-catenin and Twist and increase sub-G1 accumulation in H2452 mesothelioma cells.	ursolic acid	91-103	poly(ADP-ribose) polymerase 1	Homo sapiens	154-158
28090191-7	2016	Furthermore, overexpression of let 7b using let-7b mimics enhanced the antitumor effect of ursolic acid to attenuate the expression of procaspases 3, pro-PARP, pAKT, beta-catenin and Twist and increase sub-G1 accumulation in H2452 mesothelioma cells.	ursolic acid	91-103	catenin beta 1	Homo sapiens	166-178
28090191-8	2016	Overall, our findings suggest that ursolic acid induces apoptosis via inhibition of EMT and activation of let7b in mesothelioma cells as a potent chemotherapeutic agent for treatment of malignant mesotheliomas.	ursolic acid	35-47	microRNA let-7b	Homo sapiens	106-111
27798869-2	2016	The current investigation demonstrated that ursolic acid (UA), a pentacyclic triterpenoid, protected hepatoma cells and reduced HBx-mediated autophagy through modulation of Ras homolog gene family member A (RhoA).	ursolic acid	44-56	ras homolog family member A	Homo sapiens	207-211
27798869-2	2016	The current investigation demonstrated that ursolic acid (UA), a pentacyclic triterpenoid, protected hepatoma cells and reduced HBx-mediated autophagy through modulation of Ras homolog gene family member A (RhoA).	ursolic acid	58-60	ras homolog family member A	Homo sapiens	207-211
27573738-0	2016	Renoprotective effects of ursolic acid on ischemia/reperfusion-induced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NF-kappaB activities.	ursolic acid	26-38	signal transducer and activator of transcription 3	Rattus norvegicus	152-157
27573738-3	2016	The present study demonstrated that pre-treatment with ursolic acid significantly increased renal functioning and attenuated increases of serum angiotensin II levels in rats subjected to I/R-IAKI.	ursolic acid	55-67	angiotensinogen	Rattus norvegicus	144-158
27573738-5	2016	Furthermore, ursolic acid significantly suppressed the upregulation of STAT3, NF-kappaB and caspase-3 activities in rats following I/R-IAKI.	ursolic acid	13-25	signal transducer and activator of transcription 3	Rattus norvegicus	71-76
27573738-5	2016	Furthermore, ursolic acid significantly suppressed the upregulation of STAT3, NF-kappaB and caspase-3 activities in rats following I/R-IAKI.	ursolic acid	13-25	caspase 3	Rattus norvegicus	92-101
27573738-6	2016	These results indicated that ursolic acid may be a potential drug for reducing I/R-IAKI through suppression of inflammation and oxidative stress damage, as well as modulation of STAT3 and NF-kappaB activities.	ursolic acid	29-41	signal transducer and activator of transcription 3	Rattus norvegicus	178-183
27698874-9	2016	The results of the present study indicate that the anticancer effect of ursolic acid activates cell apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.	ursolic acid	72-84	phosphatase and tensin homolog	Homo sapiens	123-127
27698874-9	2016	The results of the present study indicate that the anticancer effect of ursolic acid activates cell apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.	ursolic acid	72-84	cofilin 1	Homo sapiens	168-177
27698874-0	2016	Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.	ursolic acid	22-34	phosphatase and tensin homolog	Homo sapiens	68-72
27698874-0	2016	Anti-cancer effect of ursolic acid activates apoptosis through ROCK/PTEN mediated mitochondrial translocation of cofilin-1 in prostate cancer.	ursolic acid	22-34	cofilin 1	Homo sapiens	113-122
27634378-10	2016	Altogether, the data provide evidence that UA"s pro-apoptotic effect in K562 cells is associated with the Gfi-1/Stat5/Akt pathway.	ursolic acid	43-45	signal transducer and activator of transcription 5A	Homo sapiens	112-117
27698874-6	2016	In the present study, ursolic acid significantly suppressed cell growth and induced apoptosis, as well as increasing caspase-3 and caspase-9 activities of DU145 cells.	ursolic acid	22-34	caspase 3	Homo sapiens	117-126
27698874-6	2016	In the present study, ursolic acid significantly suppressed cell growth and induced apoptosis, as well as increasing caspase-3 and caspase-9 activities of DU145 cells.	ursolic acid	22-34	caspase 9	Homo sapiens	131-140
27698874-7	2016	Furthermore, cytoplasmic and mitochondrial cytochrome c protein expression was significantly activated and suppressed, respectively, by ursolic acid.	ursolic acid	136-148	cytochrome c, somatic	Homo sapiens	43-55
27698874-8	2016	Ursolic acid significantly suppressed the ROCK/PTEN signaling pathway and inhibited cofilin-1 protein expression in DU145 cells.	ursolic acid	0-12	phosphatase and tensin homolog	Homo sapiens	47-51
27698874-8	2016	Ursolic acid significantly suppressed the ROCK/PTEN signaling pathway and inhibited cofilin-1 protein expression in DU145 cells.	ursolic acid	0-12	cofilin 1	Homo sapiens	84-93
27634378-0	2016	Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1.	ursolic acid	0-12	signal transducer and activator of transcription 5A	Homo sapiens	55-60
27634378-10	2016	Altogether, the data provide evidence that UA"s pro-apoptotic effect in K562 cells is associated with the Gfi-1/Stat5/Akt pathway.	ursolic acid	43-45	AKT serine/threonine kinase 1	Homo sapiens	118-121
27634378-0	2016	Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	61-64
27453990-7	2016	Tumor cell selective apoptotic action of UA was mainly attributed due to the activation of extrinsic apoptosis pathway via up regulation of DR4, DR5 and PARP cleavage in MCF-7 cells over non-tumorigenic MCF-10A cells.	ursolic acid	41-43	major histocompatibility complex, class II, DR beta 4	Homo sapiens	140-143
27634378-0	2016	Ursolic acid-mediated apoptosis of K562 cells involves Stat5/Akt pathway inhibition through the induction of Gfi-1.	ursolic acid	0-12	growth factor independent 1 transcriptional repressor	Homo sapiens	109-114
27634378-5	2016	Gfi-1 knockdown using siRNA abrogates the ability of UA to decrease Stat5b expression and attenuates apoptosis induction by UA.	ursolic acid	53-55	growth factor independent 1 transcriptional repressor	Homo sapiens	0-5
27634378-5	2016	Gfi-1 knockdown using siRNA abrogates the ability of UA to decrease Stat5b expression and attenuates apoptosis induction by UA.	ursolic acid	53-55	signal transducer and activator of transcription 5B	Homo sapiens	68-74
27634378-6	2016	We also demonstrate that UA suppresses the Akt kinase activity by inhibiting Akt1/2 expression, which correlates with Stat5 inhibition.	ursolic acid	25-27	AKT serine/threonine kinase 1	Homo sapiens	43-46
27634378-6	2016	We also demonstrate that UA suppresses the Akt kinase activity by inhibiting Akt1/2 expression, which correlates with Stat5 inhibition.	ursolic acid	25-27	AKT serine/threonine kinase 1	Homo sapiens	77-83
27634378-6	2016	We also demonstrate that UA suppresses the Akt kinase activity by inhibiting Akt1/2 expression, which correlates with Stat5 inhibition.	ursolic acid	25-27	signal transducer and activator of transcription 5A	Homo sapiens	118-123
27634378-10	2016	Altogether, the data provide evidence that UA"s pro-apoptotic effect in K562 cells is associated with the Gfi-1/Stat5/Akt pathway.	ursolic acid	43-45	growth factor independent 1 transcriptional repressor	Homo sapiens	106-111
27604859-0	2016	Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1alpha.	ursolic acid	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	87-91
27604859-0	2016	Ursolic acid sensitized colon cancer cells to chemotherapy under hypoxia by inhibiting MDR1 through HIF-1alpha.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	100-110
27604859-10	2016	Moreover, ursolic acid was capable of inhibiting HIF-1alpha accumulation with little effects on its constitutional expression in normoxia.	ursolic acid	10-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
27604859-12	2016	CONCLUSIONS: Ursolic acid exerted chemosensitizing effects in colon cancer cells under hypoxia by inhibiting HIF-1alpha accumulation and the subsequent expression of the MDR1 and VEGF.	ursolic acid	13-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
27604859-12	2016	CONCLUSIONS: Ursolic acid exerted chemosensitizing effects in colon cancer cells under hypoxia by inhibiting HIF-1alpha accumulation and the subsequent expression of the MDR1 and VEGF.	ursolic acid	13-25	ATP binding cassette subfamily B member 1	Homo sapiens	170-174
27470332-2	2016	In studying the potential role of the hypothalamus in aging, we developed a strategy to pursue UA effects on the hypothalamus anti-aging proteins such as; SIRT1, SIRT6, PGC-1beta and alpha-Klotho.	ursolic acid	95-97	sirtuin 1	Mus musculus	155-160
27470332-2	2016	In studying the potential role of the hypothalamus in aging, we developed a strategy to pursue UA effects on the hypothalamus anti-aging proteins such as; SIRT1, SIRT6, PGC-1beta and alpha-Klotho.	ursolic acid	95-97	sirtuin 6	Mus musculus	162-167
27470332-6	2016	The data illustrated that UA significantly increased SIRT1 (~3.5+-0.3 folds) and SIRT-6 (~1.5+-0.2 folds) proteins overexpression (P&lt;0.001).	ursolic acid	26-28	sirtuin 1	Mus musculus	53-58
27470332-6	2016	The data illustrated that UA significantly increased SIRT1 (~3.5+-0.3 folds) and SIRT-6 (~1.5+-0.2 folds) proteins overexpression (P&lt;0.001).	ursolic acid	26-28	sirtuin 6	Mus musculus	81-87
27470332-7	2016	In addition, our results showed that UA enhanced alpha-Klotho (~3.3+-0.3) and PGC-1beta (~2.6+-0.2 folds) proteins levels (P&lt;0.	ursolic acid	37-39	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	Mus musculus	78-87
27470332-10	2016	To the best of our knowledge, it seems that UA through enhancing of anti-aging biomarkers (SIRT1 and SIRT6) and PGC-1beta in hypothalamus regulates aging-process and attenuates mitochondrial-related diseases.	ursolic acid	44-46	sirtuin 1	Mus musculus	91-96
27470332-10	2016	To the best of our knowledge, it seems that UA through enhancing of anti-aging biomarkers (SIRT1 and SIRT6) and PGC-1beta in hypothalamus regulates aging-process and attenuates mitochondrial-related diseases.	ursolic acid	44-46	sirtuin 6	Mus musculus	101-106
27331824-1	2016	OBJECTIVE: Ursolic acid administration following resistance exercise increases mammalian target of rapamycin complex 1 (mTORC1) activity and skeletal muscle IGF-1 concentration in murines in a manner similar to l-leucine yet remains unexamined in humans.	ursolic acid	11-23	CREB regulated transcription coactivator 1	Mus musculus	120-126
27331824-1	2016	OBJECTIVE: Ursolic acid administration following resistance exercise increases mammalian target of rapamycin complex 1 (mTORC1) activity and skeletal muscle IGF-1 concentration in murines in a manner similar to l-leucine yet remains unexamined in humans.	ursolic acid	11-23	insulin like growth factor 1	Homo sapiens	157-162
27331824-2	2016	This study examined serum and skeletal muscle insulin-like growth factor-1 (IGF-1) and Akt/mTORC1 signaling activity following ingestion of either ursolic acid or l-leucine immediately after resistance exercise.	ursolic acid	147-159	AKT serine/threonine kinase 1	Homo sapiens	87-90
27514536-0	2016	SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid.	ursolic acid	72-84	sirtuin 1	Homo sapiens	0-5
27514536-10	2016	UA treatment induced autophagy, enhanced SIRT1 expression, and decreased acetylation of lysine residue on Atg5.	ursolic acid	0-2	sirtuin 1	Homo sapiens	41-46
27514536-12	2016	In summary, UA exerted antiatherosclerosis effects in quails and protected HUVECs from ox-LDL induced cytotoxicity, and the mechanism is associated with increased SIRT1 expression, decreased Atg5 acetylation on lysine residue, and increased autophagy.	ursolic acid	12-14	sirtuin 1	Homo sapiens	163-168
27496965-0	2016	Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors.	ursolic acid	0-12	TNF superfamily member 10	Homo sapiens	52-57
27496965-0	2016	Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors.	ursolic acid	0-12	tumor protein p53	Homo sapiens	84-87
27474355-8	2016	These findings collectively indicate that UGT1A3 and UGT1A4 were the main enzymes responsible for the glucuronidation of UA in human.	ursolic acid	121-123	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	42-48
27474355-8	2016	These findings collectively indicate that UGT1A3 and UGT1A4 were the main enzymes responsible for the glucuronidation of UA in human.	ursolic acid	121-123	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	53-59
27453990-7	2016	Tumor cell selective apoptotic action of UA was mainly attributed due to the activation of extrinsic apoptosis pathway via up regulation of DR4, DR5 and PARP cleavage in MCF-7 cells over non-tumorigenic MCF-10A cells.	ursolic acid	41-43	TNF receptor superfamily member 10b	Homo sapiens	145-148
27453990-7	2016	Tumor cell selective apoptotic action of UA was mainly attributed due to the activation of extrinsic apoptosis pathway via up regulation of DR4, DR5 and PARP cleavage in MCF-7 cells over non-tumorigenic MCF-10A cells.	ursolic acid	41-43	poly(ADP-ribose) polymerase 1	Homo sapiens	153-157
27508051-0	2016	Ursolic acid attenuates temozolomide resistance in glioblastoma cells by downregulating O(6)-methylguanine-DNA methyltransferase (MGMT) expression.	ursolic acid	0-12	O-6-methylguanine-DNA methyltransferase	Homo sapiens	88-128
27508051-0	2016	Ursolic acid attenuates temozolomide resistance in glioblastoma cells by downregulating O(6)-methylguanine-DNA methyltransferase (MGMT) expression.	ursolic acid	0-12	O-6-methylguanine-DNA methyltransferase	Homo sapiens	130-134
27262506-0	2016	Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells.	ursolic acid	14-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
27262506-8	2016	Furthermore, we showed that anti-proliferative and proapoptotic effects of UA were mediated through modulation of multiple signaling pathways including Akt and ERK-1/2 proteins.	ursolic acid	75-77	AKT serine/threonine kinase 1	Homo sapiens	152-155
27262506-8	2016	Furthermore, we showed that anti-proliferative and proapoptotic effects of UA were mediated through modulation of multiple signaling pathways including Akt and ERK-1/2 proteins.	ursolic acid	75-77	mitogen-activated protein kinase 3	Homo sapiens	160-167
27332074-7	2016	Furthermore, UA significantly suppressed the upregulation of IL-1beta, IL-6, and tumor necrosis-alpha factor levels in the hippocampus of Abeta25-35-treated mice.	ursolic acid	13-15	interleukin 1 beta	Mus musculus	61-69
27260468-0	2016	Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.	ursolic acid	41-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
27260468-6	2016	However, the epigenetic impact of UA on Nrf2 signaling remains poorly understood in skin cancer.	ursolic acid	34-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	40-44
27260468-9	2016	Under this condition, UA induced the expression of the Nrf2-mediated detoxifying/antioxidant enzymes heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferase 1A1.	ursolic acid	22-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
27260468-9	2016	Under this condition, UA induced the expression of the Nrf2-mediated detoxifying/antioxidant enzymes heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferase 1A1.	ursolic acid	22-24	heme oxygenase 1	Mus musculus	101-151
27260468-9	2016	Under this condition, UA induced the expression of the Nrf2-mediated detoxifying/antioxidant enzymes heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferase 1A1.	ursolic acid	22-24	UDP glucuronosyltransferase 1 family, polypeptide A1	Mus musculus	156-187
27221674-0	2016	Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1alpha in vitro.	ursolic acid	0-12	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	112-117
27221674-0	2016	Ursolic acid inhibits proliferation and reverses drug resistance of ovarian cancer stem cells by downregulating ABCG2 through suppressing the expression of hypoxia-inducible factor-1alpha in vitro.	ursolic acid	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-187
27221674-5	2016	The expression of HIF-1alpha and ABCG2 was tested using quantitative PCR, western blotting, and immuno-fluorescence under different culture conditions and treated with UA.	ursolic acid	168-170	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
27221674-5	2016	The expression of HIF-1alpha and ABCG2 was tested using quantitative PCR, western blotting, and immuno-fluorescence under different culture conditions and treated with UA.	ursolic acid	168-170	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	33-38
27221674-9	2016	UA could inhibit proliferation and reverse the drug resistance of ovarian CSC by suppressing ABCG2 and HIF-1alpha under different culture conditions.	ursolic acid	0-2	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	93-98
27221674-9	2016	UA could inhibit proliferation and reverse the drug resistance of ovarian CSC by suppressing ABCG2 and HIF-1alpha under different culture conditions.	ursolic acid	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	103-113
27221674-10	2016	HIF-1alpha inhibitor YC-1 combined with UA suppressed the stemness genes and ABCG2 under hypoxic condition.	ursolic acid	40-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	77-82
27221674-11	2016	The PI3K/Akt signaling pathway activation plays an important functional role in UA-induced downregulation of HIF-1alpha and reduction of ABCG2.	ursolic acid	80-82	AKT serine/threonine kinase 1	Homo sapiens	9-12
27221674-11	2016	The PI3K/Akt signaling pathway activation plays an important functional role in UA-induced downregulation of HIF-1alpha and reduction of ABCG2.	ursolic acid	80-82	hypoxia inducible factor 1 subunit alpha	Homo sapiens	109-119
27221674-11	2016	The PI3K/Akt signaling pathway activation plays an important functional role in UA-induced downregulation of HIF-1alpha and reduction of ABCG2.	ursolic acid	80-82	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	137-142
27221674-12	2016	UA inhibits the proliferation and reversal of drug resistance in ovarian CSCs by suppressing the expression of downregulation of HIF-1alpha and ABCG2.	ursolic acid	0-2	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
27221674-12	2016	UA inhibits the proliferation and reversal of drug resistance in ovarian CSCs by suppressing the expression of downregulation of HIF-1alpha and ABCG2.	ursolic acid	0-2	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	144-149
27085898-0	2016	Ursolic acid induced anti-proliferation effects in rat primary vascular smooth muscle cells is associated with inhibition of microRNA-21 and subsequent PTEN/PI3K.	ursolic acid	0-12	phosphatase and tensin homolog	Rattus norvegicus	152-156
27085898-6	2016	Furthermore, UA inhibited the expression of miRNA-21 and subsequently enhanced the expression of PTEN.	ursolic acid	13-15	phosphatase and tensin homolog	Rattus norvegicus	97-101
27085898-8	2016	In conclusion, UA exerts anti-proliferation effects in rat primary VSMCs, which is associated with the inhibition of miRNA-21 expression and modulation of PTEN/PI3K signaling pathway.	ursolic acid	15-17	phosphatase and tensin homolog	Rattus norvegicus	155-159
27332074-7	2016	Furthermore, UA significantly suppressed the upregulation of IL-1beta, IL-6, and tumor necrosis-alpha factor levels in the hippocampus of Abeta25-35-treated mice.	ursolic acid	13-15	interleukin 6	Mus musculus	71-75
27171502-0	2016	Ursolic Acid Triggers Apoptosis in Human Osteosarcoma Cells via Caspase Activation and the ERK1/2 MAPK Pathway.	ursolic acid	0-12	mitogen-activated protein kinase 3	Homo sapiens	91-97
27171502-3	2016	Furthermore, exposure to UA induced intracellular oxidative stress and collapse of mitochondrial membrane permeability, resulting in the subsequent activation of apoptotic caspases 8, 9, and 3 as well as PARP cleavage, and ultimately apoptosis in MG-63 cells.	ursolic acid	25-27	collagen type XI alpha 2 chain	Homo sapiens	204-208
27171502-4	2016	Moreover, protein analysis of mitogen-activated protein kinase (MAPK)-related protein expression showed an increase in activated ERK1/2, JNK, and p38 MAPK in UA-treated MG-63 cells.	ursolic acid	158-160	mitogen-activated protein kinase 3	Homo sapiens	129-135
27171502-4	2016	Moreover, protein analysis of mitogen-activated protein kinase (MAPK)-related protein expression showed an increase in activated ERK1/2, JNK, and p38 MAPK in UA-treated MG-63 cells.	ursolic acid	158-160	mitogen-activated protein kinase 8	Homo sapiens	137-140
27171502-5	2016	In addition, UA-induced apoptosis was significantly abolished in MG-63 cells that had been pretreated with inhibitors of caspase 3, 8, and 9 and ERK1/2.	ursolic acid	13-15	caspase 3	Homo sapiens	121-130
27171502-5	2016	In addition, UA-induced apoptosis was significantly abolished in MG-63 cells that had been pretreated with inhibitors of caspase 3, 8, and 9 and ERK1/2.	ursolic acid	13-15	mitogen-activated protein kinase 3	Homo sapiens	145-151
27171502-6	2016	Furthermore, UA-treated MG-63 cells also exhibited an enhancement in Bax/Bcl-2 ratio, whereas anti-apoptotic XIAP and survivin were down-regulated.	ursolic acid	13-15	BCL2 associated X, apoptosis regulator	Homo sapiens	69-72
27171502-6	2016	Furthermore, UA-treated MG-63 cells also exhibited an enhancement in Bax/Bcl-2 ratio, whereas anti-apoptotic XIAP and survivin were down-regulated.	ursolic acid	13-15	BCL2 apoptosis regulator	Homo sapiens	73-78
27171502-6	2016	Furthermore, UA-treated MG-63 cells also exhibited an enhancement in Bax/Bcl-2 ratio, whereas anti-apoptotic XIAP and survivin were down-regulated.	ursolic acid	13-15	X-linked inhibitor of apoptosis	Homo sapiens	109-113
27171502-7	2016	Taken together, we provide evidence demonstrating that UA mediates caspase-dependent and ERK1/2 MAPK-associated apoptosis in osteosarcoma MG-63 cells.	ursolic acid	55-57	mitogen-activated protein kinase 3	Homo sapiens	89-95
27082984-8	2016	UA also reduced the DSS-stimulated high nuclear level of NF-kappaB p65 in the colon tissues.	ursolic acid	0-2	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	67-70
27063951-4	2016	Cell culture study showed that UA enhanced autophagy of macrophages by increasing the expression of Atg5 and Atg16l1, which led to altered macrophage function.	ursolic acid	31-33	autophagy related 5	Mus musculus	100-104
27063951-4	2016	Cell culture study showed that UA enhanced autophagy of macrophages by increasing the expression of Atg5 and Atg16l1, which led to altered macrophage function.	ursolic acid	31-33	autophagy related 16-like 1 (S. cerevisiae)	Mus musculus	109-116
27063951-9	2016	In LDLR(-/-) mice fed a Western diet to induce atherogenesis, UA treatment significantly reduced atherosclerotic lesion size, accompanied by increased macrophage autophagy.	ursolic acid	62-64	low density lipoprotein receptor	Mus musculus	3-7
27017606-12	2016	An in vitro isotope tracing experiment showed that COT and its bioactive ingredients, such as celastrol, ursolic acid, oleanolic acid, and quercetin, significantly increased the efflux of (3)H-cholesterol.	ursolic acid	105-117	mitogen-activated protein kinase kinase kinase 8	Mus musculus	51-54
27063951-10	2016	In conclusion, the data suggest that UA promotes macrophage autophagy and, thereby, suppresses IL-1beta secretion, promotes cholesterol efflux, and attenuates atherosclerosis in mice.	ursolic acid	37-39	interleukin 1 beta	Mus musculus	95-103
27090933-0	2016	Ursolic acid and rosiglitazone combination improves insulin sensitivity by increasing the skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat diet-fed C57BL/6J mice.	ursolic acid	0-12	insulin receptor substrate 1	Mus musculus	125-130
27090933-7	2016	Further, combination treatment (UA/RSG) stimulated the IRS-1, PI3-kinase, Akt, and GLUT 4 translocation.	ursolic acid	32-34	insulin receptor substrate 1	Mus musculus	55-60
27090933-7	2016	Further, combination treatment (UA/RSG) stimulated the IRS-1, PI3-kinase, Akt, and GLUT 4 translocation.	ursolic acid	32-34	thymoma viral proto-oncogene 1	Mus musculus	74-77
27090933-7	2016	Further, combination treatment (UA/RSG) stimulated the IRS-1, PI3-kinase, Akt, and GLUT 4 translocation.	ursolic acid	32-34	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	83-89
27090933-8	2016	These results strongly suggest that combination treatment (UA/RSG) activates IRS-PI3-kinase-Akt-dependent signaling pathways to induce GLUT 4 translocation and increases the expression of insulin receptor to improve glucose intolerance.	ursolic acid	59-61	thymoma viral proto-oncogene 1	Mus musculus	92-95
27090933-8	2016	These results strongly suggest that combination treatment (UA/RSG) activates IRS-PI3-kinase-Akt-dependent signaling pathways to induce GLUT 4 translocation and increases the expression of insulin receptor to improve glucose intolerance.	ursolic acid	59-61	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	135-141
27090933-8	2016	These results strongly suggest that combination treatment (UA/RSG) activates IRS-PI3-kinase-Akt-dependent signaling pathways to induce GLUT 4 translocation and increases the expression of insulin receptor to improve glucose intolerance.	ursolic acid	59-61	insulin receptor	Mus musculus	188-204
27108888-0	2016	Ursolic acid prevents augmented peripheral inflammation and inflammatory hyperalgesia in high-fat diet-induced obese rats by restoring downregulated spinal PPARalpha.	ursolic acid	0-12	peroxisome proliferator activated receptor alpha	Rattus norvegicus	156-165
27108888-3	2016	Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, has been shown to upregulate PPARalpha in the peripheral tissues of obese animals.	ursolic acid	0-12	peroxisome proliferator activated receptor alpha	Rattus norvegicus	100-109
27108888-3	2016	Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, has been shown to upregulate PPARalpha in the peripheral tissues of obese animals.	ursolic acid	14-16	peroxisome proliferator activated receptor alpha	Rattus norvegicus	100-109
27108888-4	2016	The present study hypothesized that UA prevents augmented peripheral inflammation and inflammatory hyperalgesia in obesity by restoring downregulated spinal PPARalpha.	ursolic acid	36-38	peroxisome proliferator activated receptor alpha	Rattus norvegicus	157-166
27108888-9	2016	Additionally, UA normalized PPARalpha activity and inhibited the exaggerated spinal cord inflammatory response to carrageenan.	ursolic acid	14-16	peroxisome proliferator activated receptor alpha	Rattus norvegicus	28-37
27108888-10	2016	Although the knockdown of spinal PPARalpha with small interfering RNA following the administration of UA did not alter obesity or metabolic parameters, it eradicated the beneficial effects of UA on thermal hyperalgesia and paw edema, and reversed the spinal cord inflammatory response.	ursolic acid	102-104	peroxisome proliferator activated receptor alpha	Rattus norvegicus	33-42
27108888-10	2016	Although the knockdown of spinal PPARalpha with small interfering RNA following the administration of UA did not alter obesity or metabolic parameters, it eradicated the beneficial effects of UA on thermal hyperalgesia and paw edema, and reversed the spinal cord inflammatory response.	ursolic acid	192-194	peroxisome proliferator activated receptor alpha	Rattus norvegicus	33-42
27108888-11	2016	These results suggested that the systemic administration of UA inhibited the exaggerated spinal cord inflammatory response to peripheral inflammatory stimulation in HFD-induced obesity by restoring downregulated spinal PPARalpha, preventing peripheral inflammation and inflammatory hyperalgesia.	ursolic acid	60-62	peroxisome proliferator activated receptor alpha	Rattus norvegicus	219-228
27219337-0	2016	Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma.	ursolic acid	37-49	AKT serine/threonine kinase 1	Homo sapiens	19-22
27219337-5	2016	Interestingly, UA at low concentrations (10-15 muM) enhanced the antitumoral effects of DXR by up to 2-fold, while in parallel inhibiting DXR-induced AKT activation and p21 expression, two proteins implicated in antitumoral drug resistance and cell survival.	ursolic acid	15-17	latexin	Homo sapiens	47-50
27219337-3	2016	UA (5-50 muM) strongly inhibited (up to 80%) the viability of STS cells at 24 h and its proliferation in soft agar, with higher concentrations increasing apoptotic death up to 30%.	ursolic acid	0-2	latexin	Homo sapiens	9-12
27219337-5	2016	Interestingly, UA at low concentrations (10-15 muM) enhanced the antitumoral effects of DXR by up to 2-fold, while in parallel inhibiting DXR-induced AKT activation and p21 expression, two proteins implicated in antitumoral drug resistance and cell survival.	ursolic acid	15-17	AKT serine/threonine kinase 1	Homo sapiens	150-153
27219337-4	2016	UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	51-54
27219337-5	2016	Interestingly, UA at low concentrations (10-15 muM) enhanced the antitumoral effects of DXR by up to 2-fold, while in parallel inhibiting DXR-induced AKT activation and p21 expression, two proteins implicated in antitumoral drug resistance and cell survival.	ursolic acid	15-17	H3 histone pseudogene 16	Homo sapiens	169-172
27219337-6	2016	In conclusion, UA is able to induce intrinsic apoptosis in human STS cells and also to sensitize these cells to DXR by blocking the AKT signalling pathway.	ursolic acid	15-17	AKT serine/threonine kinase 1	Homo sapiens	132-135
27219337-4	2016	UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis.	ursolic acid	0-2	glycogen synthase kinase 3 beta	Homo sapiens	55-63
27219337-4	2016	UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis.	ursolic acid	0-2	catenin beta 1	Homo sapiens	64-76
27219337-4	2016	UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis.	ursolic acid	0-2	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	165-170
27219337-4	2016	UA treatment (6-9 h) strongly blocked the survival AKT/GSK3beta/beta-catenin signalling pathway, which led to a concomitant reduction of the anti-apoptotic proteins c-Myc and p21, altogether resulting in the activation of intrinsic apoptosis.	ursolic acid	0-2	H3 histone pseudogene 16	Homo sapiens	175-178
27188169-0	2016	Erratum to: Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells.	ursolic acid	77-89	insulin like growth factor binding protein 1	Homo sapiens	32-38
27188169-0	2016	Erratum to: Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells.	ursolic acid	77-89	forkhead box O3	Homo sapiens	43-49
27274199-2	2016	Ursolic acid (UA) may act as a PPARgamma agonist and serve as an anti-inflammatory agent.	ursolic acid	0-12	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	31-40
27274199-2	2016	Ursolic acid (UA) may act as a PPARgamma agonist and serve as an anti-inflammatory agent.	ursolic acid	14-16	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	31-40
27274199-11	2016	Both the PPARgamma protein level and the percentage of PPARgamma-positive cells were increased in the UA-treated groups (P&lt;0.01).	ursolic acid	102-104	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	9-18
27036874-0	2016	Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells.	ursolic acid	65-77	insulin-like growth factor binding protein 1	Mus musculus	20-26
27274199-11	2016	Both the PPARgamma protein level and the percentage of PPARgamma-positive cells were increased in the UA-treated groups (P&lt;0.01).	ursolic acid	102-104	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	55-64
27274199-12	2016	Compared with the control group, the UA-treated groups exhibited reduced protein levels of MMP2, MMP9, and activated MAPKs (P&lt;0.01) but an increased level of TIMP1 (P&lt;0.01).	ursolic acid	37-39	matrix metallopeptidase 2	Rattus norvegicus	91-95
27274199-12	2016	Compared with the control group, the UA-treated groups exhibited reduced protein levels of MMP2, MMP9, and activated MAPKs (P&lt;0.01) but an increased level of TIMP1 (P&lt;0.01).	ursolic acid	37-39	matrix metallopeptidase 9	Rattus norvegicus	97-101
27274199-12	2016	Compared with the control group, the UA-treated groups exhibited reduced protein levels of MMP2, MMP9, and activated MAPKs (P&lt;0.01) but an increased level of TIMP1 (P&lt;0.01).	ursolic acid	37-39	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	161-166
27274199-14	2016	Co-treatment with UA and bisphenol A diglycidyl ether completely abolished the UA-induced changes in PPARgamma expression; however UA continued to exert a significant but partial neuroprotective effect.	ursolic acid	18-20	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	101-110
27274199-14	2016	Co-treatment with UA and bisphenol A diglycidyl ether completely abolished the UA-induced changes in PPARgamma expression; however UA continued to exert a significant but partial neuroprotective effect.	ursolic acid	79-81	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	101-110
27274199-15	2016	CONCLUSION: UA can act as a PPARgamma agonist to improve the metalloprotease/anti-metalloprotease balance, possibly by inhibiting the activation of the MAPK signaling pathway, thereby attenuating cerebral ischemia and reperfusion injury.	ursolic acid	12-14	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	28-37
26907155-4	2016	Among all the tested compounds, 10o showed potent sPLA2 inhibition activity, that is comparable or more to ursolic acid (positive control).	ursolic acid	107-119	phospholipase A2 group X	Homo sapiens	50-55
27104510-0	2016	The Apoptotic Effect of Ursolic Acid on SK-Hep-1 Cells is Regulated by the PI3K/Akt, p38 and JNK MAPK Signaling Pathways.	ursolic acid	24-36	AKT serine/threonine kinase 1	Homo sapiens	80-83
27104510-0	2016	The Apoptotic Effect of Ursolic Acid on SK-Hep-1 Cells is Regulated by the PI3K/Akt, p38 and JNK MAPK Signaling Pathways.	ursolic acid	24-36	mitogen-activated protein kinase 14	Homo sapiens	85-88
27104510-0	2016	The Apoptotic Effect of Ursolic Acid on SK-Hep-1 Cells is Regulated by the PI3K/Akt, p38 and JNK MAPK Signaling Pathways.	ursolic acid	24-36	mitogen-activated protein kinase 8	Homo sapiens	93-96
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	126-131
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	BCL2 like 1	Homo sapiens	133-139
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	BCL2 apoptosis regulator	Homo sapiens	141-146
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	tumor protein, translationally-controlled 1	Homo sapiens	152-156
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	tumor necrosis factor	Homo sapiens	212-221
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	Fas associated via death domain	Homo sapiens	228-232
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	BCL2 associated X, apoptosis regulator	Homo sapiens	234-237
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	caspase 3	Homo sapiens	247-256
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	caspase 8	Homo sapiens	258-267
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	caspase 9	Homo sapiens	269-278
27104510-6	2016	The western blot results revealed that exposure to UA was associated with decreased expression of the anti-apoptotic proteins Mcl-1, Bcl-xL, Bcl-2, and TCTP and increased expression of apoptosis-related proteins TNF-alpha, Fas, FADD, Bax, cleaved caspase-3, caspase-8, caspase-9, and PARP.	ursolic acid	51-53	collagen type XI alpha 2 chain	Homo sapiens	284-288
27104510-7	2016	Immunocytochemistry staining showed that treatment with UA resulted in increased expression of caspase-3.	ursolic acid	56-58	caspase 3	Homo sapiens	95-104
27104510-8	2016	Moreover, exposure to UA resulted in the inhibition of the PI3K/Akt and p38 MAPK signaling pathways.	ursolic acid	22-24	AKT serine/threonine kinase 1	Homo sapiens	64-67
27104510-8	2016	Moreover, exposure to UA resulted in the inhibition of the PI3K/Akt and p38 MAPK signaling pathways.	ursolic acid	22-24	mitogen-activated protein kinase 14	Homo sapiens	72-75
27036874-0	2016	Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells.	ursolic acid	65-77	forkhead box O3	Mus musculus	31-37
27036874-10	2016	RESULTS: We showed that UA stimulated phosphorylation of p38 MAPK.	ursolic acid	24-26	mitogen-activated protein kinase 14	Mus musculus	57-65
27036874-12	2016	Intriguingly, we showed that UA increased the expression of FOXO3a and that overexpressed FOXO3a enhanced phosphorylation of p38 MAPK, all of which were not observed in cells silencing of endogenous IGFBP1 gene.	ursolic acid	29-31	forkhead box O3	Mus musculus	60-66
27036874-12	2016	Intriguingly, we showed that UA increased the expression of FOXO3a and that overexpressed FOXO3a enhanced phosphorylation of p38 MAPK, all of which were not observed in cells silencing of endogenous IGFBP1 gene.	ursolic acid	29-31	forkhead box O3	Mus musculus	90-96
27036874-12	2016	Intriguingly, we showed that UA increased the expression of FOXO3a and that overexpressed FOXO3a enhanced phosphorylation of p38 MAPK, all of which were not observed in cells silencing of endogenous IGFBP1 gene.	ursolic acid	29-31	mitogen-activated protein kinase 14	Mus musculus	125-133
27036874-12	2016	Intriguingly, we showed that UA increased the expression of FOXO3a and that overexpressed FOXO3a enhanced phosphorylation of p38 MAPK, all of which were not observed in cells silencing of endogenous IGFBP1 gene.	ursolic acid	29-31	insulin-like growth factor binding protein 1	Mus musculus	199-205
27036874-13	2016	Moreover, exogenous expressed IGFBP1 strengthened UA-induced phosphorylation of p38 MAPK and FOXO3a protein expression, and more importantly, restored the effect of UA-inhibited growth in cells silencing of endogenous IGFBP1 gene.	ursolic acid	50-52	insulin-like growth factor binding protein 1	Mus musculus	30-36
27036874-13	2016	Moreover, exogenous expressed IGFBP1 strengthened UA-induced phosphorylation of p38 MAPK and FOXO3a protein expression, and more importantly, restored the effect of UA-inhibited growth in cells silencing of endogenous IGFBP1 gene.	ursolic acid	50-52	mitogen-activated protein kinase 14	Mus musculus	80-88
27036874-13	2016	Moreover, exogenous expressed IGFBP1 strengthened UA-induced phosphorylation of p38 MAPK and FOXO3a protein expression, and more importantly, restored the effect of UA-inhibited growth in cells silencing of endogenous IGFBP1 gene.	ursolic acid	50-52	forkhead box O3	Mus musculus	93-99
27036874-13	2016	Moreover, exogenous expressed IGFBP1 strengthened UA-induced phosphorylation of p38 MAPK and FOXO3a protein expression, and more importantly, restored the effect of UA-inhibited growth in cells silencing of endogenous IGFBP1 gene.	ursolic acid	50-52	insulin-like growth factor binding protein 1	Mus musculus	218-224
27036874-13	2016	Moreover, exogenous expressed IGFBP1 strengthened UA-induced phosphorylation of p38 MAPK and FOXO3a protein expression, and more importantly, restored the effect of UA-inhibited growth in cells silencing of endogenous IGFBP1 gene.	ursolic acid	165-167	insulin-like growth factor binding protein 1	Mus musculus	30-36
27036874-13	2016	Moreover, exogenous expressed IGFBP1 strengthened UA-induced phosphorylation of p38 MAPK and FOXO3a protein expression, and more importantly, restored the effect of UA-inhibited growth in cells silencing of endogenous IGFBP1 gene.	ursolic acid	165-167	insulin-like growth factor binding protein 1	Mus musculus	218-224
27036874-14	2016	Consistent with these, UA suppressed tumor growth and increased phosphorylation of p38 MAPK, protein expressions of IGFBP1 and FOXO3a in vivo.	ursolic acid	23-25	mitogen-activated protein kinase 14	Mus musculus	83-91
27036874-14	2016	Consistent with these, UA suppressed tumor growth and increased phosphorylation of p38 MAPK, protein expressions of IGFBP1 and FOXO3a in vivo.	ursolic acid	23-25	insulin-like growth factor binding protein 1	Mus musculus	116-122
27036874-14	2016	Consistent with these, UA suppressed tumor growth and increased phosphorylation of p38 MAPK, protein expressions of IGFBP1 and FOXO3a in vivo.	ursolic acid	23-25	forkhead box O3	Mus musculus	127-133
27036874-15	2016	CONCLUSION: Collectively, our results show that UA inhibits growth of HCC cells through p38 MAPK-mediated induction of IGFBP1 and FOXO3a expression.	ursolic acid	48-50	mitogen-activated protein kinase 14	Mus musculus	88-91
27036874-15	2016	CONCLUSION: Collectively, our results show that UA inhibits growth of HCC cells through p38 MAPK-mediated induction of IGFBP1 and FOXO3a expression.	ursolic acid	48-50	insulin-like growth factor binding protein 1	Mus musculus	119-125
27036874-15	2016	CONCLUSION: Collectively, our results show that UA inhibits growth of HCC cells through p38 MAPK-mediated induction of IGFBP1 and FOXO3a expression.	ursolic acid	48-50	forkhead box O3	Mus musculus	130-136
27036874-16	2016	The interactions between IGFBP1 and FOXO3a, and feedback regulatory loop of p38 MAPK by IGFBP1 and FOXO3a resulting in reciprocal pathways, contribute to the overall effects of UA.	ursolic acid	177-179	insulin-like growth factor binding protein 1	Mus musculus	25-31
27036874-16	2016	The interactions between IGFBP1 and FOXO3a, and feedback regulatory loop of p38 MAPK by IGFBP1 and FOXO3a resulting in reciprocal pathways, contribute to the overall effects of UA.	ursolic acid	177-179	forkhead box O3	Mus musculus	36-42
27036874-16	2016	The interactions between IGFBP1 and FOXO3a, and feedback regulatory loop of p38 MAPK by IGFBP1 and FOXO3a resulting in reciprocal pathways, contribute to the overall effects of UA.	ursolic acid	177-179	mitogen-activated protein kinase 14	Mus musculus	76-79
27036874-16	2016	The interactions between IGFBP1 and FOXO3a, and feedback regulatory loop of p38 MAPK by IGFBP1 and FOXO3a resulting in reciprocal pathways, contribute to the overall effects of UA.	ursolic acid	177-179	insulin-like growth factor binding protein 1	Mus musculus	88-94
27036874-16	2016	The interactions between IGFBP1 and FOXO3a, and feedback regulatory loop of p38 MAPK by IGFBP1 and FOXO3a resulting in reciprocal pathways, contribute to the overall effects of UA.	ursolic acid	177-179	forkhead box O3	Mus musculus	99-105
27036874-17	2016	This in vitro and in vivo study corroborates a potential novel mechanism by which UA controls HCC growth and implies that the rational targeting IGFBP1 and FOXO3a can be potential for the therapeutic strategy against HCC.	ursolic acid	82-84	insulin-like growth factor binding protein 1	Mus musculus	145-151
27036874-17	2016	This in vitro and in vivo study corroborates a potential novel mechanism by which UA controls HCC growth and implies that the rational targeting IGFBP1 and FOXO3a can be potential for the therapeutic strategy against HCC.	ursolic acid	82-84	forkhead box O3	Mus musculus	156-162
27114690-13	2016	SUMMARY: Melaleuca leucadendron is a good source for ursolic acid.Confirming traditional use for type II diabetes via PTP1B inhibition.	ursolic acid	53-65	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	118-123
26909608-5	2016	UA (20 muM) also enhanced gemcitabine (200 nM)-induced apoptosis and suppressed the expression of NF-kappaB-regulated proteins.	ursolic acid	0-2	latexin	Homo sapiens	7-10
26909608-8	2016	Immunohistochemical analysis showed that biomarkers of proliferation (Ki-67) and microvessel density (CD31) were suppressed by the combination of UA and gemcitabine.	ursolic acid	146-148	platelet and endothelial cell adhesion molecule 1	Homo sapiens	102-106
26909608-9	2016	UA inhibited the activation of NF-kappaB and STAT3 and the expression of tumorigenic proteins regulated by these inflammatory transcription factors in tumor tissue.	ursolic acid	0-2	signal transducer and activator of transcription 3	Homo sapiens	45-50
26898441-0	2016	Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation.	ursolic acid	11-23	sirtuin 1	Mus musculus	83-88
26898441-5	2016	Treatment of the cells with UA showed that UA up-regulated SIRT1 (~35 folds) and overexpressed PGC-1alpha (~175 folds) gene significantly.	ursolic acid	28-30	sirtuin 1	Mus musculus	59-64
26898441-5	2016	Treatment of the cells with UA showed that UA up-regulated SIRT1 (~35 folds) and overexpressed PGC-1alpha (~175 folds) gene significantly.	ursolic acid	28-30	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	95-105
26898441-5	2016	Treatment of the cells with UA showed that UA up-regulated SIRT1 (~35 folds) and overexpressed PGC-1alpha (~175 folds) gene significantly.	ursolic acid	43-45	sirtuin 1	Mus musculus	59-64
26898441-5	2016	Treatment of the cells with UA showed that UA up-regulated SIRT1 (~35 folds) and overexpressed PGC-1alpha (~175 folds) gene significantly.	ursolic acid	43-45	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	95-105
26898441-10	2016	Alternatively, UA enhanced the expression of myoglobin (~2 folds) in concert with remodeling of glycolytic muscle fibers to mainly fast IIA (~30%) and slow-twitch (~4%) types as well.	ursolic acid	15-17	myoglobin	Mus musculus	45-54
26582056-0	2016	p21 induction plays a dual role in anti-cancer activity of ursolic acid.	ursolic acid	59-71	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	0-3
26582056-1	2016	Previous studies have shown that induction of G1 arrest and apoptosis by ursolic acid is associated with up-regulation of cyclin-dependent kinase inhibitor (CDKI) protein p21 in multiple types of cancer cells.	ursolic acid	73-85	cyclin-dependent kinase inhibitor 1C (P57)	Mus musculus	122-155
26582056-1	2016	Previous studies have shown that induction of G1 arrest and apoptosis by ursolic acid is associated with up-regulation of cyclin-dependent kinase inhibitor (CDKI) protein p21 in multiple types of cancer cells.	ursolic acid	73-85	cyclin-dependent kinase inhibitor 1C (P57)	Mus musculus	157-161
26582056-1	2016	Previous studies have shown that induction of G1 arrest and apoptosis by ursolic acid is associated with up-regulation of cyclin-dependent kinase inhibitor (CDKI) protein p21 in multiple types of cancer cells.	ursolic acid	73-85	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	171-174
26582056-2	2016	However, the functional role of p21 induction in G1 cell cycle arrest and apoptosis, and the mechanisms of p21 induction by ursolic acid have not been critically addressed.	ursolic acid	124-136	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	107-110
26582056-3	2016	In the current study, we demonstrated that p21 played a mediator role in G1 cell cycle arrest by ursolic acid, whereas p21-mediated up-regulation of Mcl-1 compromised apoptotic effect of ursolic acid.	ursolic acid	97-109	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	43-46
26582056-3	2016	In the current study, we demonstrated that p21 played a mediator role in G1 cell cycle arrest by ursolic acid, whereas p21-mediated up-regulation of Mcl-1 compromised apoptotic effect of ursolic acid.	ursolic acid	187-199	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	119-122
26582056-3	2016	In the current study, we demonstrated that p21 played a mediator role in G1 cell cycle arrest by ursolic acid, whereas p21-mediated up-regulation of Mcl-1 compromised apoptotic effect of ursolic acid.	ursolic acid	187-199	myeloid cell leukemia sequence 1	Mus musculus	149-154
26582056-4	2016	These results suggest that p21 induction plays a dual role in the anti-cancer activity of ursolic acid in terms of cell cycle and apoptosis regulation.	ursolic acid	90-102	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	27-30
26582056-5	2016	p21 induction by ursolic acid was attributed to p53 transcriptional activation.	ursolic acid	17-29	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	0-3
26582056-5	2016	p21 induction by ursolic acid was attributed to p53 transcriptional activation.	ursolic acid	17-29	transformation related protein 53, pseudogene	Mus musculus	48-51
26582056-6	2016	Moreover, we found that ursolic acid was able to inhibit murine double minute-2 protein (MDM2) and T-LAK cell-originated protein kinase (TOPK), the two negative regulator of p53, which in turn contributed to ursolic acid-induced p53 activation.	ursolic acid	24-36	transformed mouse 3T3 cell double minute 2	Mus musculus	64-87
26582056-6	2016	Moreover, we found that ursolic acid was able to inhibit murine double minute-2 protein (MDM2) and T-LAK cell-originated protein kinase (TOPK), the two negative regulator of p53, which in turn contributed to ursolic acid-induced p53 activation.	ursolic acid	24-36	transformed mouse 3T3 cell double minute 2	Mus musculus	89-93
26582056-6	2016	Moreover, we found that ursolic acid was able to inhibit murine double minute-2 protein (MDM2) and T-LAK cell-originated protein kinase (TOPK), the two negative regulator of p53, which in turn contributed to ursolic acid-induced p53 activation.	ursolic acid	24-36	transformation related protein 53, pseudogene	Mus musculus	174-177
26582056-6	2016	Moreover, we found that ursolic acid was able to inhibit murine double minute-2 protein (MDM2) and T-LAK cell-originated protein kinase (TOPK), the two negative regulator of p53, which in turn contributed to ursolic acid-induced p53 activation.	ursolic acid	24-36	transformation related protein 53, pseudogene	Mus musculus	229-232
26582056-6	2016	Moreover, we found that ursolic acid was able to inhibit murine double minute-2 protein (MDM2) and T-LAK cell-originated protein kinase (TOPK), the two negative regulator of p53, which in turn contributed to ursolic acid-induced p53 activation.	ursolic acid	208-220	transformation related protein 53, pseudogene	Mus musculus	174-177
26513475-0	2015	Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.	ursolic acid	13-25	VRK serine/threonine kinase 1	Homo sapiens	69-94
26777089-4	2016	Two natural well known HNE inhibitors from the triterpene family, ursolic acid and oleanolic acid, were tested to validate the developed assay.	ursolic acid	66-78	elastase, neutrophil expressed	Homo sapiens	23-26
26777089-14	2016	Furthermore, MST technique was used for evaluating HNE interaction with the ursolic acid.	ursolic acid	76-88	elastase, neutrophil expressed	Homo sapiens	51-54
26777089-15	2016	Up to 16 capillaries were automatically processed to obtain in one titration experiment the dissociation constant for the HNE-ursolic acid complex.	ursolic acid	126-138	elastase, neutrophil expressed	Homo sapiens	122-125
26657265-3	2016	AIM OF THE STUDY: Study was designed to investigate the inhibition potential of the standardized SC extract along with its bioactive molecule ursolic acid on hepatic drug metabolizing isozymes (CYP3A4 and CYP2D6) and further some heavy metals were also analysed of the plant material.	ursolic acid	142-154	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	205-211
26657265-8	2016	CYP3A4 and CYP2D6 inhibitory effect of SC and ursolic acid (IC50: 197.49+-2.68, 211.45+-3.54 and IC50: 229.25+-2.52, 212.66+-1.26 microg/mL) was less as compared to that known inhibitors, ketoconazole and quinidine respectively.	ursolic acid	46-58	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	11-17
28003581-7	2016	Asiatic acid, corosolic acid, glycyrrhetinic acid, oleanolic acid and ursolic acid suppressed octanoylated ghrelin levels in AGS-GHRL8 cells without decreasing transcript expression of GOAT or furin, a protease required for ghrelin maturation.	ursolic acid	70-82	appetite-regulating hormone	Capra hircus	107-114
28003581-7	2016	Asiatic acid, corosolic acid, glycyrrhetinic acid, oleanolic acid and ursolic acid suppressed octanoylated ghrelin levels in AGS-GHRL8 cells without decreasing transcript expression of GOAT or furin, a protease required for ghrelin maturation.	ursolic acid	70-82	appetite-regulating hormone	Capra hircus	224-231
26446926-11	2016	Docking studies demonstrated that Noni phytochemicals, damnacanthal, myricetin and ursolic acid, are potent inhibitors of ERK with binding sites in the catalytic and phosphorylation sites of the molecule.	ursolic acid	83-95	Eph receptor B1	Rattus norvegicus	122-125
26338703-6	2015	Interestingly, a subset of the mRNAs repressed by ursolic acid and tomatidine in aged muscle are positively regulated by activating transcription factor 4 (ATF4).	ursolic acid	50-62	activating transcription factor 4	Mus musculus	121-154
26338703-6	2015	Interestingly, a subset of the mRNAs repressed by ursolic acid and tomatidine in aged muscle are positively regulated by activating transcription factor 4 (ATF4).	ursolic acid	50-62	activating transcription factor 4	Mus musculus	156-160
26338703-10	2015	In addition, these results identify ursolic acid and tomatidine as potential agents and/or lead compounds for reducing ATF4 activity, weakness, and atrophy in aged skeletal muscle.	ursolic acid	36-48	activating transcription factor 4	Mus musculus	119-123
26151624-5	2015	Reverse transcription-quantitative polymerase chain reaction of nuclear factor-kappaB essential modifier (NEMO) was performed to delineate the role of the apoptotic pathway following treatment with UA.	ursolic acid	198-200	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	106-110
26412148-0	2015	Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells.	ursolic acid	0-12	VRK serine/threonine kinase 1	Homo sapiens	56-81
26412148-4	2015	We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1.	ursolic acid	14-26	VRK serine/threonine kinase 1	Homo sapiens	67-71
26412148-4	2015	We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1.	ursolic acid	14-26	VRK serine/threonine kinase 1	Homo sapiens	118-122
26412148-4	2015	We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1.	ursolic acid	28-30	VRK serine/threonine kinase 1	Homo sapiens	67-71
26412148-4	2015	We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1.	ursolic acid	28-30	VRK serine/threonine kinase 1	Homo sapiens	118-122
26412148-5	2015	UA weakens surveillance mechanisms by blocking 53BP1 foci formation induced by VRK1 in lung cancer cells, and possesses synergistic anti-cancer effects with DNA damaging drugs.	ursolic acid	0-2	tumor protein p53 binding protein 1	Homo sapiens	47-52
26412148-5	2015	UA weakens surveillance mechanisms by blocking 53BP1 foci formation induced by VRK1 in lung cancer cells, and possesses synergistic anti-cancer effects with DNA damaging drugs.	ursolic acid	0-2	VRK serine/threonine kinase 1	Homo sapiens	79-83
26362062-0	2015	Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.	ursolic acid	113-125	DNA methyltransferase 1	Homo sapiens	77-100
26362062-0	2015	Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.	ursolic acid	113-125	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	105-109
26362062-8	2015	Furthermore, we found that UA induced phosphorylation of SAPK/JNK and suppressed the protein expression of DNMT1 and EZH2.	ursolic acid	27-29	DNA methyltransferase 1	Homo sapiens	107-112
26362062-8	2015	Furthermore, we found that UA induced phosphorylation of SAPK/JNK and suppressed the protein expression of DNMT1 and EZH2.	ursolic acid	27-29	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	117-121
26362062-11	2015	Conversely, overexpression of SP1 reversed the effect of UA on DNMT1 and EZH2 expression, and feedback attenuated UA-induced phosphorylation of SAPK/JNK.	ursolic acid	57-59	DNA methyltransferase 1	Homo sapiens	63-68
26362062-11	2015	Conversely, overexpression of SP1 reversed the effect of UA on DNMT1 and EZH2 expression, and feedback attenuated UA-induced phosphorylation of SAPK/JNK.	ursolic acid	57-59	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	73-77
26362062-12	2015	Moreover, exogenous expression of DNMT1 antagonized the effect of UA on SAPK/JNK signaling, EZH2 protein expression, and NSCLC cell growth.	ursolic acid	66-68	DNA methyltransferase 1	Homo sapiens	34-39
26362062-13	2015	CONCLUSION: Our results show that UA inhibits growth of NSCLC cells through SAPK/JNK-mediated inhibition of SP1; this in turn results in inhibition the expression of DNMT1 and EZH2.	ursolic acid	34-36	DNA methyltransferase 1	Homo sapiens	166-171
26362062-13	2015	CONCLUSION: Our results show that UA inhibits growth of NSCLC cells through SAPK/JNK-mediated inhibition of SP1; this in turn results in inhibition the expression of DNMT1 and EZH2.	ursolic acid	34-36	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	176-180
26362062-15	2015	The negative feedback regulation of SAPK/JNK signaling by SP1 and DNMT1, and the reciprocal interaction of EZH2 and DNMT1 contribute to the overall effects of UA.	ursolic acid	159-161	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	107-111
26362062-15	2015	The negative feedback regulation of SAPK/JNK signaling by SP1 and DNMT1, and the reciprocal interaction of EZH2 and DNMT1 contribute to the overall effects of UA.	ursolic acid	159-161	DNA methyltransferase 1	Homo sapiens	116-121
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	epidermal growth factor receptor	Mus musculus	98-102
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	signal transducer and activator of transcription 3	Mus musculus	104-109
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	Rous sarcoma oncogene	Mus musculus	111-114
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	thymoma viral proto-oncogene 1	Mus musculus	116-119
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	cytochrome c oxidase II, mitochondrial	Mus musculus	121-126
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	mitogen-activated protein kinase 14	Mus musculus	144-152
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	jun proto-oncogene	Mus musculus	154-159
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	mitogen-activated protein kinase 8	Mus musculus	165-169
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	226-229
26100520-4	2015	The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds.	ursolic acid	19-31	programmed cell death 4	Mus musculus	234-239
26100520-6	2015	Combined treatment with ursolic acid + resveratrol resulted in a greater inhibition of expression of proinflammatory cytokines, including Il1a, Il1b, and Il22.	ursolic acid	24-36	interleukin 1 alpha	Mus musculus	138-142
26100520-6	2015	Combined treatment with ursolic acid + resveratrol resulted in a greater inhibition of expression of proinflammatory cytokines, including Il1a, Il1b, and Il22.	ursolic acid	24-36	interleukin 1 beta	Mus musculus	144-148
26100520-6	2015	Combined treatment with ursolic acid + resveratrol resulted in a greater inhibition of expression of proinflammatory cytokines, including Il1a, Il1b, and Il22.	ursolic acid	24-36	interleukin 22	Mus musculus	154-158
26100520-7	2015	Furthermore, NF-kappaB, Egr-1, and AP-1 DNA binding activities after TPA treatment were dramatically decreased by the combination of ursolic acid + resveratrol.	ursolic acid	133-145	early growth response 1	Mus musculus	24-29
26100520-7	2015	Furthermore, NF-kappaB, Egr-1, and AP-1 DNA binding activities after TPA treatment were dramatically decreased by the combination of ursolic acid + resveratrol.	ursolic acid	133-145	jun proto-oncogene	Mus musculus	35-39
26711605-15	2015	CONCLUSION: UA may inhibit the formation of new blood vessels through reducing the expressions of VEGF, COX-2 and MMP-2 in retinal tissues, and promote a remission from DR by obvious resistance to oxidative stress.	ursolic acid	12-14	vascular endothelial growth factor A	Mus musculus	98-102
25930119-0	2015	Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1).	ursolic acid	0-12	tryptophan hydroxylase 1	Rattus norvegicus	61-85
25930119-0	2015	Ursolic acid derivatives as bone anabolic agents targeted to tryptophan hydroxylase 1 (Tph-1).	ursolic acid	0-12	tryptophan hydroxylase 1	Rattus norvegicus	87-92
26711605-15	2015	CONCLUSION: UA may inhibit the formation of new blood vessels through reducing the expressions of VEGF, COX-2 and MMP-2 in retinal tissues, and promote a remission from DR by obvious resistance to oxidative stress.	ursolic acid	12-14	prostaglandin-endoperoxide synthase 2	Mus musculus	104-109
26153652-6	2015	Moreover, using this proposed method, the inhibition effect of 6-chloro-3-formyl-7-methylchromone, betulinic acid, ursolic acid, and sodium orthovanadate on PTP1B activity can be tested with IC50 values of 10, 13, 9, and 1.1 muM, respectively.	ursolic acid	115-127	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	157-162
26711605-15	2015	CONCLUSION: UA may inhibit the formation of new blood vessels through reducing the expressions of VEGF, COX-2 and MMP-2 in retinal tissues, and promote a remission from DR by obvious resistance to oxidative stress.	ursolic acid	12-14	matrix metallopeptidase 2	Mus musculus	114-119
25903305-0	2015	Downregulation of miR-21 is involved in direct actions of ursolic acid on the heart: implications for cardiac fibrosis and hypertrophy.	ursolic acid	58-70	microRNA 21a	Mus musculus	18-24
25903305-9	2015	Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo.	ursolic acid	92-94	microRNA 21a	Mus musculus	18-24
25903305-9	2015	Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo.	ursolic acid	92-94	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	29-34
25903305-9	2015	Downregulation of miR-21 and p-ERK/ERK were observed in myocardial fibroblasts treated with UA in a dose-dependent manner compared with the control group both in vitro and in vivo.	ursolic acid	92-94	mitogen-activated protein kinase 1	Mus musculus	31-34
25903305-10	2015	CONCLUSIONS: Our study demonstrates that UA can inhibit myocardial fibrosis both in vitro and in vivo, and the effects of UA on myocardial fibrosis may be due to the inhibition of miR-21/ERK signaling pathways.	ursolic acid	41-43	mitogen-activated protein kinase 1	Mus musculus	187-190
25903305-10	2015	CONCLUSIONS: Our study demonstrates that UA can inhibit myocardial fibrosis both in vitro and in vivo, and the effects of UA on myocardial fibrosis may be due to the inhibition of miR-21/ERK signaling pathways.	ursolic acid	122-124	microRNA 21a	Mus musculus	180-186
25903305-10	2015	CONCLUSIONS: Our study demonstrates that UA can inhibit myocardial fibrosis both in vitro and in vivo, and the effects of UA on myocardial fibrosis may be due to the inhibition of miR-21/ERK signaling pathways.	ursolic acid	122-124	mitogen-activated protein kinase 1	Mus musculus	187-190
25944715-0	2015	Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and beta-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.	ursolic acid	0-12	uncoupling protein 3	Rattus norvegicus	109-113
25944715-0	2015	Ursolic acid increases energy expenditure through enhancing free fatty acid uptake and beta-oxidation via an UCP3/AMPK-dependent pathway in skeletal muscle.	ursolic acid	0-12	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	114-118
25944715-10	2015	CONCLUSION: UA increases FFA burning through enhancing skeletal muscle FFA uptake and beta-oxidation via an UCP3/AMPK-dependent pathway, which provides a novel perspective on the biological function of UA against obesity and IR.	ursolic acid	12-14	uncoupling protein 3	Rattus norvegicus	108-112
25944715-10	2015	CONCLUSION: UA increases FFA burning through enhancing skeletal muscle FFA uptake and beta-oxidation via an UCP3/AMPK-dependent pathway, which provides a novel perspective on the biological function of UA against obesity and IR.	ursolic acid	12-14	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	113-117
25944715-10	2015	CONCLUSION: UA increases FFA burning through enhancing skeletal muscle FFA uptake and beta-oxidation via an UCP3/AMPK-dependent pathway, which provides a novel perspective on the biological function of UA against obesity and IR.	ursolic acid	202-204	uncoupling protein 3	Rattus norvegicus	108-112
25944715-10	2015	CONCLUSION: UA increases FFA burning through enhancing skeletal muscle FFA uptake and beta-oxidation via an UCP3/AMPK-dependent pathway, which provides a novel perspective on the biological function of UA against obesity and IR.	ursolic acid	202-204	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	113-117
25867469-2	2015	Ursolic acid (UA) is a pentacyclic triterpenoid with anti-inflammatory and immunomodulatory properties, especially inhibiting IL-17.	ursolic acid	0-12	interleukin 17A	Homo sapiens	126-131
25892149-5	2015	In vivo, UA treatment (0.14%, w/w) significantly decreased the liver weight, serum levels of ALT/AST and hepatic steatosis in db/db mice (a type 2 diabetic mouse model).	ursolic acid	9-11	glutamic pyruvic transaminase, soluble	Mus musculus	93-96
25892149-5	2015	In vivo, UA treatment (0.14%, w/w) significantly decreased the liver weight, serum levels of ALT/AST and hepatic steatosis in db/db mice (a type 2 diabetic mouse model).	ursolic acid	9-11	transmembrane protease, serine 11d	Mus musculus	97-100
26347199-0	2015	A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver.	ursolic acid	73-85	mitogen-activated protein kinase 1	Homo sapiens	154-157
26347199-0	2015	A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver.	ursolic acid	73-85	AKT serine/threonine kinase 1	Homo sapiens	164-167
26347199-0	2015	A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver.	ursolic acid	73-85	mitogen-activated protein kinase 14	Homo sapiens	173-176
26347199-0	2015	A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver.	ursolic acid	73-85	mitogen-activated protein kinase 1	Homo sapiens	177-181
26347199-6	2015	The subsequential benchmarking data showed that UA significantly reduced the accumulation of type I collagen in HSCs in rat liver, increased the expression level of MMP-1, but decreased the expression level of TIMP-1 in HSC-T6 cells.	ursolic acid	48-50	matrix metallopeptidase 1	Rattus norvegicus	165-170
26347199-6	2015	The subsequential benchmarking data showed that UA significantly reduced the accumulation of type I collagen in HSCs in rat liver, increased the expression level of MMP-1, but decreased the expression level of TIMP-1 in HSC-T6 cells.	ursolic acid	48-50	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	210-216
26347199-8	2015	Furthermore, UA remarkably attenuated oxidative stress via negative regulation of NOX4 activity and expression in HSC-T6 cells.	ursolic acid	13-15	NADPH oxidase 4	Rattus norvegicus	82-86
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	ursolic acid	195-197	Eph receptor B1	Rattus norvegicus	120-123
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	ursolic acid	195-197	mitogen activated protein kinase 14	Rattus norvegicus	139-142
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	ursolic acid	195-197	mitogen-activated protein kinase 1	Homo sapiens	143-147
26347199-9	2015	The employment of specific chemical inhibitors, SB203580, LY294002, PD98059, and AG490, demonstrated the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in the regulatory effect of UA on NOX4 activity and expression.	ursolic acid	195-197	NADPH oxidase 4	Rattus norvegicus	201-205
26347199-10	2015	Collectively, the antifibrotic effect of UA is partially due to the oxidative stress attenuating effect through manipulating NOX4 activity and expression.	ursolic acid	41-43	NADPH oxidase 4	Rattus norvegicus	125-129
25976755-3	2015	This study seeks to address the two following questions: primarily, we wonder to know if UA increases anti-aging biomarkers (SIRT1 and PGC-1alpha) in the isolated satellite cells, to pave the way for satellite cells proliferation.	ursolic acid	89-91	sirtuin 1	Sus scrofa	125-130
25976755-3	2015	This study seeks to address the two following questions: primarily, we wonder to know if UA increases anti-aging biomarkers (SIRT1 and PGC-1alpha) in the isolated satellite cells, to pave the way for satellite cells proliferation.	ursolic acid	89-91	PPARG coactivator 1 alpha	Sus scrofa	135-145
25976755-11	2015	The results indicated that UA through increasing myoglobin expression (~ 2 folds) accompanied with transforming of glycolytic to fast oxidative status chiefly and slow-twitch muscle fibers.	ursolic acid	27-29	myoglobin	Mus musculus	49-58
25406534-11	2015	Furthermore, our data demonstrated that UA activated the phagocytosis process in human monocyte cells through MRP8 induction.	ursolic acid	40-42	ATP binding cassette subfamily C member 8	Homo sapiens	110-114
25762784-5	2015	Furthermore, ursolic acid suppressed NF-kappaB activation and inhibited the downregulation of Cbl-b in wild-type T cells.	ursolic acid	13-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-46
25762784-5	2015	Furthermore, ursolic acid suppressed NF-kappaB activation and inhibited the downregulation of Cbl-b in wild-type T cells.	ursolic acid	13-25	Casitas B-lineage lymphoma b	Mus musculus	94-99
25867469-2	2015	Ursolic acid (UA) is a pentacyclic triterpenoid with anti-inflammatory and immunomodulatory properties, especially inhibiting IL-17.	ursolic acid	14-16	interleukin 17A	Homo sapiens	126-131
25529824-0	2015	The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblasts through the mTOR signaling pathway.	ursolic acid	19-31	mechanistic target of rapamycin kinase	Mus musculus	114-118
25681755-4	2015	The results indicated that UA could inhibit receptor activator of nuclear factor-kappaB ligand (RANKL)-mediated osteoclastogenesis and the bone resorptive function of osteoclasts in a concentration-dependent manner in vitro.	ursolic acid	27-29	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	96-101
25681755-5	2015	Further, UA effectively inhibited the mRNA and protein expression of NFATc1, primarily via the suppression of nuclear factor-kappaB (NF-kappaB) signaling, and partly through the suppression of c-Jun N-terminal kinase (JNK) signaling.	ursolic acid	9-11	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	69-75
25681755-5	2015	Further, UA effectively inhibited the mRNA and protein expression of NFATc1, primarily via the suppression of nuclear factor-kappaB (NF-kappaB) signaling, and partly through the suppression of c-Jun N-terminal kinase (JNK) signaling.	ursolic acid	9-11	mitogen-activated protein kinase 8	Mus musculus	193-216
25681755-5	2015	Further, UA effectively inhibited the mRNA and protein expression of NFATc1, primarily via the suppression of nuclear factor-kappaB (NF-kappaB) signaling, and partly through the suppression of c-Jun N-terminal kinase (JNK) signaling.	ursolic acid	9-11	mitogen-activated protein kinase 8	Mus musculus	218-221
25681755-6	2015	Additionally, UA treatment downregulated the expression of NFATc1-regulated osteoclast marker genes.	ursolic acid	14-16	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	59-65
25681755-7	2015	Likewise, UA induced dose-dependent attenuation of titanium (Ti) particle-induced mouse calvarial bone loss, and decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts.	ursolic acid	10-12	acid phosphatase 5, tartrate resistant	Mus musculus	137-172
25681755-7	2015	Likewise, UA induced dose-dependent attenuation of titanium (Ti) particle-induced mouse calvarial bone loss, and decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts.	ursolic acid	10-12	acid phosphatase 5, tartrate resistant	Mus musculus	174-178
25547067-0	2015	Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPKalpha-mediated reduction of DNA methyltransferase 1.	ursolic acid	0-12	DNA methyltransferase 1	Homo sapiens	110-133
25547067-7	2015	Furthermore, we found that UA induced phosphorylation of AMP-activated protein kinase alpha (AMPKalpha) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner.	ursolic acid	27-29	DNA methyltransferase 1	Homo sapiens	145-168
25547067-7	2015	Furthermore, we found that UA induced phosphorylation of AMP-activated protein kinase alpha (AMPKalpha) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner.	ursolic acid	27-29	DNA methyltransferase 1	Homo sapiens	170-175
25547067-11	2015	Collectively, our results show for the first time that UA inhibits growth of HCC through AMPKalpha-mediated inhibition of Sp1; this in turn results in inhibition of DNMT1.	ursolic acid	55-57	DNA methyltransferase 1	Homo sapiens	165-170
25547067-12	2015	This study reveals a potential novel mechanism by which UA controls growth of HCC cells and suggests that DNMT1 could be novel target for HCC chemoprevention and treatment.	ursolic acid	56-58	DNA methyltransferase 1	Homo sapiens	106-111
25454976-6	2015	RESULTS: The results revealed that UA treatment markedly improved the survival of septic rats, and attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, infiltration of leukocytes and proteins, myeloperoxidase activity, and malondialdehyde content.	ursolic acid	35-37	myeloperoxidase	Rattus norvegicus	226-241
25529824-10	2015	The combination of ursolic acid and leucine significantly induced the expression of myogenic differentiation marker genes, such as myogenic differentiation 1 (MyoD) and myogenin, at both the mRNA and protein level.	ursolic acid	19-31	myogenic differentiation 1	Mus musculus	131-157
25529824-10	2015	The combination of ursolic acid and leucine significantly induced the expression of myogenic differentiation marker genes, such as myogenic differentiation 1 (MyoD) and myogenin, at both the mRNA and protein level.	ursolic acid	19-31	myogenic differentiation 1	Mus musculus	159-163
25973027-0	2015	Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.	ursolic acid	8-20	prominin 1	Homo sapiens	101-106
25168399-0	2015	Suppression of oxidative stress and improvement of liver functions in mice by ursolic acid via LKB1-AMP-activated protein kinase signaling.	ursolic acid	78-90	serine/threonine kinase 11	Mus musculus	95-99
25168399-8	2015	RESULTS: Treatment of hepatocytes with UA dose-dependently activates AMPK, which is abolished by silence of liver kinase B1 (LKB1).	ursolic acid	39-41	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	69-73
25168399-8	2015	RESULTS: Treatment of hepatocytes with UA dose-dependently activates AMPK, which is abolished by silence of liver kinase B1 (LKB1).	ursolic acid	39-41	serine/threonine kinase 11	Mus musculus	108-123
25168399-8	2015	RESULTS: Treatment of hepatocytes with UA dose-dependently activates AMPK, which is abolished by silence of liver kinase B1 (LKB1).	ursolic acid	39-41	serine/threonine kinase 11	Mus musculus	125-129
25168399-11	2015	Importantly, silence of LKB1, AMPK, or iNOS/Cox-2 by small interference RNA transfection reversed UA-induced effects in cultured cells.	ursolic acid	98-100	serine/threonine kinase 11	Mus musculus	24-28
25168399-11	2015	Importantly, silence of LKB1, AMPK, or iNOS/Cox-2 by small interference RNA transfection reversed UA-induced effects in cultured cells.	ursolic acid	98-100	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	30-34
25689721-0	2015	Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.	ursolic acid	0-12	microRNA 21	Homo sapiens	98-106
25689721-0	2015	Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.	ursolic acid	0-12	phosphatase and tensin homolog	Rattus norvegicus	107-111
25689721-0	2015	Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.	ursolic acid	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
25689721-0	2015	Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Rattus norvegicus	116-120
25689721-1	2015	OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions.	ursolic acid	40-52	microRNA 21	Homo sapiens	87-95
25689721-1	2015	OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions.	ursolic acid	40-52	AKT serine/threonine kinase 1	Homo sapiens	156-159
25689721-1	2015	OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions.	ursolic acid	40-52	mechanistic target of rapamycin kinase	Homo sapiens	161-190
25689721-1	2015	OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions.	ursolic acid	40-52	mechanistic target of rapamycin kinase	Homo sapiens	192-196
25689721-8	2015	Ursolic acid and LY294002 inhibited HG-induced mesangial cell hypertrophy and proliferation, down-regulated p85PI3K, pAkt, pmTOR, p62/SQSTMI, and collagen I expression and up-regulated LC3II expression.	ursolic acid	0-12	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	130-133
25689721-10	2015	Ursolic acid down-regulated miRNA-21 expression and up-regulated PTEN protein and mRNA expression.	ursolic acid	0-12	microRNA 21	Homo sapiens	28-36
25689721-10	2015	Ursolic acid down-regulated miRNA-21 expression and up-regulated PTEN protein and mRNA expression.	ursolic acid	0-12	phosphatase and tensin homolog	Rattus norvegicus	65-69
25689721-11	2015	CONCLUSIONS: Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation.	ursolic acid	13-25	microRNA 21	Homo sapiens	87-95
25689721-11	2015	CONCLUSIONS: Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation.	ursolic acid	13-25	phosphatase and tensin homolog	Rattus norvegicus	121-125
25689721-11	2015	CONCLUSIONS: Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation.	ursolic acid	13-25	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
25689721-11	2015	CONCLUSIONS: Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation.	ursolic acid	13-25	mechanistic target of rapamycin kinase	Rattus norvegicus	174-178
25230943-8	2015	Apoptosis was considerably increased by UA, indicated by enhancement of an Annexin-V positive population and a sub-G1 peak.	ursolic acid	40-42	annexin A5	Homo sapiens	75-84
25230943-9	2015	UA induced proteolytic processing of caspase-3.	ursolic acid	0-2	caspase 3	Homo sapiens	37-46
25515785-5	2015	Studies using an antioxidant (dimethylthiourea) indicated that the suppression of mitochondrial ROS completely abrogated the UA-induced enhancement of mitochondrial uncoupling and glutathione reductase (GR)-mediated glutathione redox cycling, as well as protection against menadione cytotoxicity in H9c2 cells.	ursolic acid	125-127	glutathione-disulfide reductase	Rattus norvegicus	180-201
25515785-5	2015	Studies using an antioxidant (dimethylthiourea) indicated that the suppression of mitochondrial ROS completely abrogated the UA-induced enhancement of mitochondrial uncoupling and glutathione reductase (GR)-mediated glutathione redox cycling, as well as protection against menadione cytotoxicity in H9c2 cells.	ursolic acid	125-127	glutathione-disulfide reductase	Rattus norvegicus	203-205
25515785-6	2015	Co-incubation with specific inhibitors of uncoupling proteins and GR almost completely prevented the cytoprotection afforded by UA against menadione-induced cytotoxicity in H9c2 cells.	ursolic acid	128-130	glutathione-disulfide reductase	Rattus norvegicus	66-68
25168399-11	2015	Importantly, silence of LKB1, AMPK, or iNOS/Cox-2 by small interference RNA transfection reversed UA-induced effects in cultured cells.	ursolic acid	98-100	nitric oxide synthase 2, inducible	Mus musculus	39-43
25168399-11	2015	Importantly, silence of LKB1, AMPK, or iNOS/Cox-2 by small interference RNA transfection reversed UA-induced effects in cultured cells.	ursolic acid	98-100	cytochrome c oxidase II, mitochondrial	Mus musculus	44-49
25360589-4	2014	In addition, administration of ursolic acid attenuated the hepatic malondialdehyde levels and reduced the plasma aspartate aminotransferase and alanine aminotransferase levels after trauma-hemorrhagic shock.	ursolic acid	31-43	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	113-139
25418615-0	2015	Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy.	ursolic acid	0-12	peroxisome proliferator activated receptor alpha	Mus musculus	95-143
25418615-1	2015	SCOPE: This study investigated metabolic effects of ursolic acid (UA), a peroxisome proliferation-activated receptor (PPAR)-alpha activator, in vivo.	ursolic acid	52-64	peroxisome proliferator activated receptor alpha	Mus musculus	73-129
25418615-1	2015	SCOPE: This study investigated metabolic effects of ursolic acid (UA), a peroxisome proliferation-activated receptor (PPAR)-alpha activator, in vivo.	ursolic acid	66-68	peroxisome proliferator activated receptor alpha	Mus musculus	73-129
25418615-4	2015	UA induced the expression of PPARalpha and its responsive genes involved in fatty acid uptake and beta-oxidation in the livers, whereas genes involved in lipogenesis, including sterol regulatory element-binding proteins-1c, were downregulated.	ursolic acid	0-2	peroxisome proliferator activated receptor alpha	Mus musculus	29-38
25418615-7	2015	CONCLUSION: Our findings suggest that UA ameliorates lipid and glucose metabolism in HFD-fed mice primarily by the activation of PPARalpha and induction of the hepatic autophagy pathway.	ursolic acid	38-40	peroxisome proliferator activated receptor alpha	Mus musculus	129-138
25621065-5	2015	Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	79-96
25621065-5	2015	Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	98-103
25621065-5	2015	Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	126-131
25621065-5	2015	Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3.	ursolic acid	0-12	caspase 3	Homo sapiens	187-196
25621065-6	2015	Furthermore, the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase was increased by the administration of ursolic acid.	ursolic acid	135-147	mitogen-activated protein kinase 14	Homo sapiens	31-34
25621065-7	2015	In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells and significantly decreased the expression of matrix metalloproteinase (MMP)-2, indicating that MMP-2 may be responsible for the anti-invasive activity of ursolic acid.	ursolic acid	13-25	matrix metallopeptidase 2	Homo sapiens	141-173
25621065-7	2015	In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells and significantly decreased the expression of matrix metalloproteinase (MMP)-2, indicating that MMP-2 may be responsible for the anti-invasive activity of ursolic acid.	ursolic acid	13-25	matrix metallopeptidase 2	Homo sapiens	191-196
25621065-7	2015	In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells and significantly decreased the expression of matrix metalloproteinase (MMP)-2, indicating that MMP-2 may be responsible for the anti-invasive activity of ursolic acid.	ursolic acid	250-262	matrix metallopeptidase 2	Homo sapiens	141-173
25621065-7	2015	In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells and significantly decreased the expression of matrix metalloproteinase (MMP)-2, indicating that MMP-2 may be responsible for the anti-invasive activity of ursolic acid.	ursolic acid	250-262	matrix metallopeptidase 2	Homo sapiens	191-196
26503559-0	2015	Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	69-72
26503559-0	2015	Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	73-77
26503559-4	2015	Treatment of human prostate cancer cells (LNCaP and PC-3) with UA inhibited the proliferation and induced apoptosis in both cell lines as characterized by the increased Annexin V-binding.	ursolic acid	63-65	annexin A5	Homo sapiens	169-178
26503559-5	2015	The induction of apoptosis by UA was associated with a decrease in the levels of Bcl-2, Bcl-xl, survivin, and activated caspase-3.	ursolic acid	30-32	BCL2 apoptosis regulator	Homo sapiens	81-86
26503559-5	2015	The induction of apoptosis by UA was associated with a decrease in the levels of Bcl-2, Bcl-xl, survivin, and activated caspase-3.	ursolic acid	30-32	BCL2 like 1	Homo sapiens	88-94
26503559-5	2015	The induction of apoptosis by UA was associated with a decrease in the levels of Bcl-2, Bcl-xl, survivin, and activated caspase-3.	ursolic acid	30-32	caspase 3	Homo sapiens	120-129
26503559-6	2015	Treatment with UA also inhibited the expression of phosphatidylinositol-3-kinase (PI3K), phosphorylation of Akt and mTOR signaling proteins.	ursolic acid	15-17	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	51-80
26503559-6	2015	Treatment with UA also inhibited the expression of phosphatidylinositol-3-kinase (PI3K), phosphorylation of Akt and mTOR signaling proteins.	ursolic acid	15-17	AKT serine/threonine kinase 1	Homo sapiens	108-111
26503559-6	2015	Treatment with UA also inhibited the expression of phosphatidylinositol-3-kinase (PI3K), phosphorylation of Akt and mTOR signaling proteins.	ursolic acid	15-17	mechanistic target of rapamycin kinase	Homo sapiens	116-120
26503559-7	2015	Further, administration of UA significantly inhibited the growth of LNCaP prostate tumor xenografts in athymic nude mice, which was associated with inhibition of cell proliferation, induction of apoptosis of tumor cells and decreased expression of PI3K downstream factors, such as p-Akt and p-mTOR in tumor xenograft tissues.	ursolic acid	27-29	AKT serine/threonine kinase 1	Homo sapiens	283-286
26503559-7	2015	Further, administration of UA significantly inhibited the growth of LNCaP prostate tumor xenografts in athymic nude mice, which was associated with inhibition of cell proliferation, induction of apoptosis of tumor cells and decreased expression of PI3K downstream factors, such as p-Akt and p-mTOR in tumor xenograft tissues.	ursolic acid	27-29	mechanistic target of rapamycin kinase	Mus musculus	293-297
26503559-8	2015	Our study demonstrates that UA not only inhibits cell growth but also induces apoptosis through modulation of the PI3K/Akt/mTOR pathway in human prostate cancer cells.	ursolic acid	28-30	AKT serine/threonine kinase 1	Homo sapiens	119-122
26503559-8	2015	Our study demonstrates that UA not only inhibits cell growth but also induces apoptosis through modulation of the PI3K/Akt/mTOR pathway in human prostate cancer cells.	ursolic acid	28-30	mechanistic target of rapamycin kinase	Homo sapiens	123-127
25312987-7	2015	Also, UA stimulates the glucose uptake through the involvement of the classical insulin signaling related to the GLUT4 translocation to the plasma membrane as well as the GLUT4 synthesis.	ursolic acid	6-8	solute carrier family 2 member 4	Rattus norvegicus	113-118
25312987-7	2015	Also, UA stimulates the glucose uptake through the involvement of the classical insulin signaling related to the GLUT4 translocation to the plasma membrane as well as the GLUT4 synthesis.	ursolic acid	6-8	solute carrier family 2 member 4	Rattus norvegicus	171-176
25312987-11	2015	CONCLUSIONS: The antihyperglycemic role of UA is mediated through insulin secretion and insulinomimetic effect on glucose uptake, synthesis and translocation of GLUT4 by a mechanism of cross-talk between calcium and protein kinases.	ursolic acid	43-45	solute carrier family 2 member 4	Rattus norvegicus	161-166
25466266-0	2014	Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway.	ursolic acid	0-12	toll-like receptor 4	Rattus norvegicus	101-105
25466266-2	2014	This study was undertaken to evaluate the influence of UA on the toll-like receptor 4 (TLR4) signaling pathway after SAH.	ursolic acid	55-57	toll-like receptor 4	Rattus norvegicus	65-85
25466266-2	2014	This study was undertaken to evaluate the influence of UA on the toll-like receptor 4 (TLR4) signaling pathway after SAH.	ursolic acid	55-57	toll-like receptor 4	Rattus norvegicus	87-91
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	toll-like receptor 4	Rattus norvegicus	56-60
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	intercellular adhesion molecule 1	Rattus norvegicus	93-126
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	intercellular adhesion molecule 1	Rattus norvegicus	128-134
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	toll-like receptor 4	Rattus norvegicus	137-164
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	interleukin 1 beta	Rattus norvegicus	182-199
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	interleukin 1 beta	Rattus norvegicus	201-209
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	tumor necrosis factor	Rattus norvegicus	212-239
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	tumor necrosis factor	Rattus norvegicus	241-250
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	interleukin 6	Rattus norvegicus	253-266
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	interleukin 6	Rattus norvegicus	268-272
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	nitric oxide synthase 2	Rattus norvegicus	275-306
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	nitric oxide synthase 2	Rattus norvegicus	308-312
25466266-5	2014	UA administration markedly decreased the expressions of TLR4 pathway-related agents, such as intercellular adhesion molecule-1 (ICAM-1), TLR4, nuclear factor-kappaB (NF-kappaB) P65, interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS) and matrix metalloproteinase (MMP)-9.	ursolic acid	0-2	matrix metallopeptidase 9	Rattus norvegicus	318-350
25466266-7	2014	In conclusion, UA may attenuate EBI after SAH in rats by suppressing the TLR4-mediated inflammatory pathway.	ursolic acid	15-17	toll-like receptor 4	Rattus norvegicus	73-77
25599805-0	2014	Corrigendum to: Ursolic Acid-Induced Elevation of Serum Irisin Augments Muscle Strength During Resistance Training in Men.	ursolic acid	16-28	fibronectin type III domain containing 5	Homo sapiens	56-62
25383044-12	2014	Annexin V/PI staining suggested that UA induced both early and late phases of apoptosis.	ursolic acid	37-39	annexin A5	Homo sapiens	0-9
25383044-15	2014	Activation of caspase-3,-9 and PARP indicated that mitochondrial pathways may be involved in UA-induced apoptosis.	ursolic acid	93-95	caspase 3	Homo sapiens	14-26
25383044-15	2014	Activation of caspase-3,-9 and PARP indicated that mitochondrial pathways may be involved in UA-induced apoptosis.	ursolic acid	93-95	poly(ADP-ribose) polymerase 1	Homo sapiens	31-35
25778894-7	2015	Likewise, expression of p65 and p50 proteins were down-regulated by ursolic acid treatment (10, 20, 40 and 80 mumol/L) (P&lt;0.01), but there was no significant change in the expression of p52 and p100.	ursolic acid	68-80	RELA proto-oncogene, NF-kB subunit	Homo sapiens	24-27
25778894-7	2015	Likewise, expression of p65 and p50 proteins were down-regulated by ursolic acid treatment (10, 20, 40 and 80 mumol/L) (P&lt;0.01), but there was no significant change in the expression of p52 and p100.	ursolic acid	68-80	nuclear factor kappa B subunit 1	Homo sapiens	32-35
25778894-8	2015	Moreover, ursolic acid could up-regulate expression of caspase-8, caspase-3 and caspase-9 protein (P&lt;0.01).	ursolic acid	10-22	caspase 8	Homo sapiens	55-64
25778894-8	2015	Moreover, ursolic acid could up-regulate expression of caspase-8, caspase-3 and caspase-9 protein (P&lt;0.01).	ursolic acid	10-22	caspase 3	Homo sapiens	66-75
25778894-8	2015	Moreover, ursolic acid could up-regulate expression of caspase-8, caspase-3 and caspase-9 protein (P&lt;0.01).	ursolic acid	10-22	caspase 9	Homo sapiens	80-89
25778894-9	2015	RT-PCR examination showed that VEGF and COX-2 mRNA expression decreased by ursolic acid treatment.	ursolic acid	75-87	vascular endothelial growth factor A	Homo sapiens	31-35
25778894-9	2015	RT-PCR examination showed that VEGF and COX-2 mRNA expression decreased by ursolic acid treatment.	ursolic acid	75-87	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
25026340-6	2014	MATERIALS AND METHODS: Uptake of radiolabeled transporter model substrates was assessed in HEK293 cells over-expressing SLC transporters including the organic anion transporters (OATs), organic anion transporting polypeptides (OATPs) and organic cation transporters (OCTs), in the presence or absence of 10.0 microM UA, OA, or GA. Their IC50 values on specific SLC transporters were also evaluated using varying concentrations of the particular compound (ranging from 0.10 nM to 80.0 microM).	ursolic acid	316-318	C-C motif chemokine ligand 21	Homo sapiens	120-123
25329874-9	2014	Furthermore, the downstream protein activities of the PI3K pathway, phosphoinositide-dependent kinase (PDK) and phosphoinositide-dependent serine/threoninekinase (AKT) were increased by 10 microM of UA in the presence of insulin.	ursolic acid	199-201	AKT serine/threonine kinase 1	Homo sapiens	163-166
25329874-10	2014	Interestingly, the activity of AS160 and protein kinase C (PKC) and the expression of glucose transporter 4 (GLUT4) were stimulated by 10 microM of UA under either the basal or insulin-stimulated status.	ursolic acid	148-150	TBC1 domain family member 4	Homo sapiens	31-36
25329874-10	2014	Interestingly, the activity of AS160 and protein kinase C (PKC) and the expression of glucose transporter 4 (GLUT4) were stimulated by 10 microM of UA under either the basal or insulin-stimulated status.	ursolic acid	148-150	solute carrier family 2 member 4	Homo sapiens	86-107
25329874-10	2014	Interestingly, the activity of AS160 and protein kinase C (PKC) and the expression of glucose transporter 4 (GLUT4) were stimulated by 10 microM of UA under either the basal or insulin-stimulated status.	ursolic acid	148-150	solute carrier family 2 member 4	Homo sapiens	109-114
25213465-1	2014	Ursolic acid, which was isolated from an ethanol extract of Cornus officinalis seed, potently inhibited nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) activation in lipopolysaccharide (LPS)-stimulated peritoneal macrophages.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	168-177
25213465-4	2014	Ursolic acid suppressed LPS-stimulated interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, and inducible NO synthetase (iNOS) expression as well as PGE2 and NO levels.	ursolic acid	0-12	tumor necrosis factor	Mus musculus	69-102
25213465-4	2014	Ursolic acid suppressed LPS-stimulated interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, and inducible NO synthetase (iNOS) expression as well as PGE2 and NO levels.	ursolic acid	0-12	nitric oxide synthase 2, inducible	Mus musculus	157-161
25213465-3	2014	Ursolic acid inhibited phosphorylation of interleukin 1 receptor-associated kinase (IRAK)1, TAK1, inhibitor of nuclear factor kappaB kinase subunit beta (IKKbeta), and IkappaBalpha as well as activation of NF-kappaB and MAPKs in LPS-stimulated macrophages.	ursolic acid	0-12	interleukin-1 receptor-associated kinase 1	Mus musculus	42-90
25213465-5	2014	Ursolic acid not only inhibited the Alexa Fluor 488-conjugated LPS-mediated shift of macrophages but also reduced the intensity of fluorescent LPS bound to the macrophages transiently transfected with or without MyD88 siRNA.	ursolic acid	0-12	myeloid differentiation primary response gene 88	Mus musculus	212-217
25213465-3	2014	Ursolic acid inhibited phosphorylation of interleukin 1 receptor-associated kinase (IRAK)1, TAK1, inhibitor of nuclear factor kappaB kinase subunit beta (IKKbeta), and IkappaBalpha as well as activation of NF-kappaB and MAPKs in LPS-stimulated macrophages.	ursolic acid	0-12	mitogen-activated protein kinase kinase kinase 7	Mus musculus	92-152
25213465-7	2014	Oral administration of ursolic acid significantly inhibited 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colon shortening and myeloperoxidase (MPO) activity in mice.	ursolic acid	23-35	myeloperoxidase	Mus musculus	131-146
25213465-7	2014	Oral administration of ursolic acid significantly inhibited 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colon shortening and myeloperoxidase (MPO) activity in mice.	ursolic acid	23-35	myeloperoxidase	Mus musculus	148-151
25213465-3	2014	Ursolic acid inhibited phosphorylation of interleukin 1 receptor-associated kinase (IRAK)1, TAK1, inhibitor of nuclear factor kappaB kinase subunit beta (IKKbeta), and IkappaBalpha as well as activation of NF-kappaB and MAPKs in LPS-stimulated macrophages.	ursolic acid	0-12	inhibitor of kappaB kinase beta	Mus musculus	154-161
25213465-8	2014	Ursolic acid also suppressed TNBS-induced COX-2 and iNOS expression as well as NF-kappaB activation in colon tissues.	ursolic acid	0-12	cytochrome c oxidase II, mitochondrial	Mus musculus	42-47
25213465-8	2014	Ursolic acid also suppressed TNBS-induced COX-2 and iNOS expression as well as NF-kappaB activation in colon tissues.	ursolic acid	0-12	nitric oxide synthase 2, inducible	Mus musculus	52-56
25213465-8	2014	Ursolic acid also suppressed TNBS-induced COX-2 and iNOS expression as well as NF-kappaB activation in colon tissues.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
25213465-9	2014	Ursolic acid (20 mg/kg) also inhibited TNBS-induced IL-1beta, IL-6, TNF-alpha by 93, 86, and 85%, respectively (p &lt; 0.05).	ursolic acid	0-12	interleukin 1 beta	Mus musculus	52-60
25213465-9	2014	Ursolic acid (20 mg/kg) also inhibited TNBS-induced IL-1beta, IL-6, TNF-alpha by 93, 86, and 85%, respectively (p &lt; 0.05).	ursolic acid	0-12	interleukin 6	Mus musculus	62-66
25213465-9	2014	Ursolic acid (20 mg/kg) also inhibited TNBS-induced IL-1beta, IL-6, TNF-alpha by 93, 86, and 85%, respectively (p &lt; 0.05).	ursolic acid	0-12	tumor necrosis factor	Mus musculus	68-77
25213465-10	2014	However, ursolic acid reversed TNBS-mediated downregulation of IL-10 expression to 79% of the normal control group (p &lt; 0.05).	ursolic acid	9-21	interleukin 10	Mus musculus	63-68
25213465-11	2014	On the basis of these findings, ursolic acid may ameliorate colitis by regulating NF-kappaB and MAPK signaling pathways via the inhibition of LPS binding to TLR4 on immune cells.	ursolic acid	32-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
25213465-11	2014	On the basis of these findings, ursolic acid may ameliorate colitis by regulating NF-kappaB and MAPK signaling pathways via the inhibition of LPS binding to TLR4 on immune cells.	ursolic acid	32-44	toll-like receptor 4	Mus musculus	157-161
25213465-3	2014	Ursolic acid inhibited phosphorylation of interleukin 1 receptor-associated kinase (IRAK)1, TAK1, inhibitor of nuclear factor kappaB kinase subunit beta (IKKbeta), and IkappaBalpha as well as activation of NF-kappaB and MAPKs in LPS-stimulated macrophages.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	168-180
25213465-3	2014	Ursolic acid inhibited phosphorylation of interleukin 1 receptor-associated kinase (IRAK)1, TAK1, inhibitor of nuclear factor kappaB kinase subunit beta (IKKbeta), and IkappaBalpha as well as activation of NF-kappaB and MAPKs in LPS-stimulated macrophages.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	206-215
25213465-4	2014	Ursolic acid suppressed LPS-stimulated interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, cyclooxygenase (COX)-2, and inducible NO synthetase (iNOS) expression as well as PGE2 and NO levels.	ursolic acid	0-12	interleukin 6	Mus musculus	63-67
24880019-0	2014	Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-kappaB activities.	ursolic acid	0-12	signal transducer and activator of transcription 3	Mus musculus	126-131
25087995-9	2014	RESULTS: UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-21 and IL-17) and oxidative stress markers (nitrotyrosine and iNOS) in arthritic joints.	ursolic acid	9-11	tumor necrosis factor	Mus musculus	163-172
25087995-9	2014	RESULTS: UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-21 and IL-17) and oxidative stress markers (nitrotyrosine and iNOS) in arthritic joints.	ursolic acid	9-11	interleukin 1 beta	Mus musculus	174-182
25087995-9	2014	RESULTS: UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-21 and IL-17) and oxidative stress markers (nitrotyrosine and iNOS) in arthritic joints.	ursolic acid	9-11	interleukin 6	Mus musculus	184-188
25087995-9	2014	RESULTS: UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-21 and IL-17) and oxidative stress markers (nitrotyrosine and iNOS) in arthritic joints.	ursolic acid	9-11	interleukin 21	Mus musculus	190-195
25087995-9	2014	RESULTS: UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6, IL-21 and IL-17) and oxidative stress markers (nitrotyrosine and iNOS) in arthritic joints.	ursolic acid	9-11	interleukin 17A	Mus musculus	200-205
25087995-10	2014	In CIA mice, UA treatment significantly decreased the number of Th17 cells, while increased the number of Treg cells in the spleens, which was consistent with decreased expression of pSTAT3, along with IL-17 and RORgammat in the splenocytes.	ursolic acid	13-15	interleukin 17A	Mus musculus	202-207
25087995-13	2014	Furthermore, UA dose-dependently suppressed the expression of B cell-associated markers Bcl-6, Blimp1 and AID mRNAs in purified CD19+ B cells pretreated with IL-21 or LPS in vitro.	ursolic acid	13-15	B cell leukemia/lymphoma 6	Mus musculus	88-93
25087995-13	2014	Furthermore, UA dose-dependently suppressed the expression of B cell-associated markers Bcl-6, Blimp1 and AID mRNAs in purified CD19+ B cells pretreated with IL-21 or LPS in vitro.	ursolic acid	13-15	PR domain containing 1, with ZNF domain	Mus musculus	95-101
25087995-13	2014	Furthermore, UA dose-dependently suppressed the expression of B cell-associated markers Bcl-6, Blimp1 and AID mRNAs in purified CD19+ B cells pretreated with IL-21 or LPS in vitro.	ursolic acid	13-15	activation-induced cytidine deaminase	Mus musculus	106-109
25087995-13	2014	Furthermore, UA dose-dependently suppressed the expression of B cell-associated markers Bcl-6, Blimp1 and AID mRNAs in purified CD19+ B cells pretreated with IL-21 or LPS in vitro.	ursolic acid	13-15	CD19 antigen	Mus musculus	128-132
25087995-13	2014	Furthermore, UA dose-dependently suppressed the expression of B cell-associated markers Bcl-6, Blimp1 and AID mRNAs in purified CD19+ B cells pretreated with IL-21 or LPS in vitro.	ursolic acid	13-15	interleukin 21	Mus musculus	158-163
25571638-12	2014	CONCLUSION: UA can significantly relieve renal damage in mice with diabetic nephropathy induced by alloxan, which might be related to decreased blood glucose level, antioxidation effect and inhibiting the production of inflammatory factors such as TNF-alpha and IL-6.	ursolic acid	12-14	tumor necrosis factor	Mus musculus	248-257
25571638-12	2014	CONCLUSION: UA can significantly relieve renal damage in mice with diabetic nephropathy induced by alloxan, which might be related to decreased blood glucose level, antioxidation effect and inhibiting the production of inflammatory factors such as TNF-alpha and IL-6.	ursolic acid	12-14	interleukin 6	Mus musculus	262-266
24992474-5	2014	The effect of UA on NF-kappaB signaling was examined by immunoblot analysis to detect IkappaBalpha phosphorylation/degradation and electrophoretic mobility shift assay to assess the DNA binding activity of NF-kappaB.	ursolic acid	14-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	20-29
24992474-5	2014	The effect of UA on NF-kappaB signaling was examined by immunoblot analysis to detect IkappaBalpha phosphorylation/degradation and electrophoretic mobility shift assay to assess the DNA binding activity of NF-kappaB.	ursolic acid	14-16	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	86-98
24992474-5	2014	The effect of UA on NF-kappaB signaling was examined by immunoblot analysis to detect IkappaBalpha phosphorylation/degradation and electrophoretic mobility shift assay to assess the DNA binding activity of NF-kappaB.	ursolic acid	14-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	206-215
24992474-9	2014	KEY FINDINGS: UA significantly inhibited the production of pro-inflammatory cytokines, IkappaBalpha phosphorylation/degradation and NF-kappaB DNA binding activity in both IEC and IL-10(-/-) peritoneal macrophages stimulated with TNF-alpha and LPS, respectively.	ursolic acid	14-16	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	87-99
24992474-9	2014	KEY FINDINGS: UA significantly inhibited the production of pro-inflammatory cytokines, IkappaBalpha phosphorylation/degradation and NF-kappaB DNA binding activity in both IEC and IL-10(-/-) peritoneal macrophages stimulated with TNF-alpha and LPS, respectively.	ursolic acid	14-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	132-141
24992474-9	2014	KEY FINDINGS: UA significantly inhibited the production of pro-inflammatory cytokines, IkappaBalpha phosphorylation/degradation and NF-kappaB DNA binding activity in both IEC and IL-10(-/-) peritoneal macrophages stimulated with TNF-alpha and LPS, respectively.	ursolic acid	14-16	interleukin 10	Mus musculus	179-184
24992474-9	2014	KEY FINDINGS: UA significantly inhibited the production of pro-inflammatory cytokines, IkappaBalpha phosphorylation/degradation and NF-kappaB DNA binding activity in both IEC and IL-10(-/-) peritoneal macrophages stimulated with TNF-alpha and LPS, respectively.	ursolic acid	14-16	tumor necrosis factor	Mus musculus	229-238
24992474-11	2014	UA also significantly ameliorated the severity of colitis in IL-10(-/-) mice.	ursolic acid	0-2	interleukin 10	Mus musculus	61-66
24992474-13	2014	SIGNIFICANCE: UA inhibits NF-kappaB activation in both IECs and macrophages, and attenuates experimental murine colitis.	ursolic acid	14-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	26-35
25352765-0	2014	Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men.	ursolic acid	0-12	fibronectin type III domain containing 5	Homo sapiens	40-46
25352765-8	2014	IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p&lt;0.05).	ursolic acid	86-88	insulin like growth factor 1	Homo sapiens	0-5
25352765-8	2014	IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p&lt;0.05).	ursolic acid	86-88	fibronectin type III domain containing 5	Homo sapiens	10-16
25352765-10	2014	These findings suggest that UA-induced elevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strength during RT.	ursolic acid	28-30	fibronectin type III domain containing 5	Homo sapiens	58-64
25238076-3	2014	Among the 14 compounds evaluated, the most promising were 3-epiursolic acid (3), 3-(hydroxyimino)oleanolic acid (9), and 3-(hydroxyimino)masticadienoic acid (13) with IC50 values of 6.5, 2.4, and 2.6 muM on catL, respectively.	ursolic acid	58-75	latexin	Homo sapiens	200-203
25238076-3	2014	Among the 14 compounds evaluated, the most promising were 3-epiursolic acid (3), 3-(hydroxyimino)oleanolic acid (9), and 3-(hydroxyimino)masticadienoic acid (13) with IC50 values of 6.5, 2.4, and 2.6 muM on catL, respectively.	ursolic acid	58-75	cathepsin L	Homo sapiens	207-211
24992474-2	2014	This study investigated the effects of UA on nuclear factor-kappa B (NF-kappaB) signaling in cells and experimental murine colitis.	ursolic acid	39-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	45-67
24992474-2	2014	This study investigated the effects of UA on nuclear factor-kappa B (NF-kappaB) signaling in cells and experimental murine colitis.	ursolic acid	39-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
28250388-13	2014	Considering the UA-mediated differential effects on cell bioenergetics, this article reviews the disparities in glucose metabolism between tumor and normal cells, along with (peroxisome proliferator-activated receptor-gamma coactivator 1alpha)-dependent mitochondrial metabolism and redox (reduction-oxidation) control to demonstrate UA-induced synthetic lethality in tumor cells.	ursolic acid	16-18	PPARG coactivator 1 alpha	Homo sapiens	175-242
24880019-0	2014	Ursolic acid ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney by inhibiting the STAT3 and NF-kappaB activities.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
24880019-3	2014	In the current report, we investigated whether UA inhibited the oxidative stress and inflammation in the kidneys of CCl4 treated mice.	ursolic acid	47-49	chemokine (C-C motif) ligand 4	Mus musculus	116-120
24880019-5	2014	Our data showed that UA significantly prevented CCl4-induced nephrotoxicity in a dose-dependent manner, indicated by both diagnostic indicators of kidney damage and histopathological analysis.	ursolic acid	21-23	chemokine (C-C motif) ligand 4	Mus musculus	48-52
24880019-6	2014	Moreover, CCl4-induced profound elevation of ROS and oxidative stress, as evidenced by the increase of lipid peroxidation level and the depletion of the total antioxidant capacity (TAC) level in the kidney, was suppressed by treatment with UA.	ursolic acid	240-242	chemokine (C-C motif) ligand 4	Mus musculus	10-14
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	tumor necrosis factor	Mus musculus	145-172
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	tumor necrosis factor	Mus musculus	174-183
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	interleukin 6	Mus musculus	186-199
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	interleukin 6	Mus musculus	201-205
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	interleukin 17A	Mus musculus	208-222
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	interleukin 17A	Mus musculus	224-229
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	prostaglandin-endoperoxide synthase 2	Mus musculus	235-251
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	prostaglandin-endoperoxide synthase 2	Mus musculus	253-258
24880019-8	2014	Furthermore, protein expression by Western blot analysis showed that UA significantly decreased production of pro-inflammatory markers including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-17 (IL-17) and cyclooxygenase-2 (COX-2) in CCl4-treated mouse kidney.	ursolic acid	69-71	chemokine (C-C motif) ligand 4	Mus musculus	263-267
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	42-44	signal transducer and activator of transcription 3	Mus musculus	120-125
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	42-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	156-178
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	42-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	180-189
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	67-69	signal transducer and activator of transcription 3	Mus musculus	120-125
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	67-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	156-178
24880019-9	2014	In exploring the underlying mechanisms of UA action, we found that UA increased the phosphorylation of transcription 3 (STAT3), which in turn activated the nuclear factor kappa B (NF-kappaB) and the inflammatory cytokines in the kidneys.	ursolic acid	67-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	180-189
24880019-10	2014	In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by UA is due at least in part to its anti-oxidant activity and its ability to modulate the STAT3 and NF-kappaB signaling pathways.	ursolic acid	91-93	chemokine (C-C motif) ligand 4	Mus musculus	62-66
24880019-10	2014	In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by UA is due at least in part to its anti-oxidant activity and its ability to modulate the STAT3 and NF-kappaB signaling pathways.	ursolic acid	91-93	signal transducer and activator of transcription 3	Mus musculus	179-184
24880019-10	2014	In conclusion, these results suggested that the inhibition of CCl4-induced inflammation by UA is due at least in part to its anti-oxidant activity and its ability to modulate the STAT3 and NF-kappaB signaling pathways.	ursolic acid	91-93	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	189-198
24802810-7	2014	The increase in free cytosolic calcium induced by UA activated the CaMKK-AMPK-mTOR kinase signaling cascade, which ultimately triggered autophagy.	ursolic acid	50-52	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	67-72
24802810-7	2014	The increase in free cytosolic calcium induced by UA activated the CaMKK-AMPK-mTOR kinase signaling cascade, which ultimately triggered autophagy.	ursolic acid	50-52	mechanistic target of rapamycin kinase	Homo sapiens	78-82
24802810-8	2014	Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells.	ursolic acid	34-36	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	69-73
24802810-8	2014	Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells.	ursolic acid	34-36	eukaryotic translation initiation factor 2A	Homo sapiens	78-87
24802810-8	2014	Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells.	ursolic acid	34-36	DNA damage inducible transcript 3	Homo sapiens	153-157
24802810-8	2014	Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells.	ursolic acid	34-36	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	210-214
24802810-8	2014	Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells.	ursolic acid	34-36	eukaryotic translation initiation factor 2A	Homo sapiens	215-224
24802810-8	2014	Western blot analysis showed that UA promoted the phosphorylation of PERK and eIF2alpha; this was followed by the upregulation of the downstream protein CHOP, implying the involvement of the ER stress-mediated PERK/eIF2alpha/CHOP pathway in glioma cells.	ursolic acid	34-36	DNA damage inducible transcript 3	Homo sapiens	225-229
24802810-10	2014	Furthermore, TUDCA and the silencing of either PERK or IRE1alpha partially blocked the UA-induced accumulation of LC3-II, suggesting that ER stress precedes the process of autophagy.	ursolic acid	87-89	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	47-51
24802810-10	2014	Furthermore, TUDCA and the silencing of either PERK or IRE1alpha partially blocked the UA-induced accumulation of LC3-II, suggesting that ER stress precedes the process of autophagy.	ursolic acid	87-89	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	55-64
24802810-11	2014	Additionally, NAC attenuated the UA-induced elevation in cytosolic calcium, ER stress markers and autophagy-related proteins, indicating that UA triggered ER stress and autophagy via a ROS-dependent pathway.	ursolic acid	33-35	synuclein alpha	Homo sapiens	14-17
24802810-11	2014	Additionally, NAC attenuated the UA-induced elevation in cytosolic calcium, ER stress markers and autophagy-related proteins, indicating that UA triggered ER stress and autophagy via a ROS-dependent pathway.	ursolic acid	142-144	synuclein alpha	Homo sapiens	14-17
24638056-0	2014	Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2.	ursolic acid	42-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-117
25059036-5	2014	UA supplement effectively decreased hepatic glucose-6-phosphatase activity and increased glucokinase activity, the glucokinase/glucose-6-phosphatase ratio, GLUT2 mRNA levels and glycogen content compared with the diabetic control mice.	ursolic acid	0-2	glucose-6-phosphatase, catalytic	Mus musculus	44-65
25059036-5	2014	UA supplement effectively decreased hepatic glucose-6-phosphatase activity and increased glucokinase activity, the glucokinase/glucose-6-phosphatase ratio, GLUT2 mRNA levels and glycogen content compared with the diabetic control mice.	ursolic acid	0-2	glucokinase	Mus musculus	89-100
25059036-5	2014	UA supplement effectively decreased hepatic glucose-6-phosphatase activity and increased glucokinase activity, the glucokinase/glucose-6-phosphatase ratio, GLUT2 mRNA levels and glycogen content compared with the diabetic control mice.	ursolic acid	0-2	glucose-6-phosphatase, catalytic	Mus musculus	127-148
25059036-5	2014	UA supplement effectively decreased hepatic glucose-6-phosphatase activity and increased glucokinase activity, the glucokinase/glucose-6-phosphatase ratio, GLUT2 mRNA levels and glycogen content compared with the diabetic control mice.	ursolic acid	0-2	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	156-161
24682498-4	2014	In the present study, the effect of ursolic acid (UA) as a candidate agent targeting ACTH-producing AtT20 cells was investigated.	ursolic acid	36-48	pro-opiomelanocortin-alpha	Mus musculus	85-89
24682498-4	2014	In the present study, the effect of ursolic acid (UA) as a candidate agent targeting ACTH-producing AtT20 cells was investigated.	ursolic acid	50-52	pro-opiomelanocortin-alpha	Mus musculus	85-89
24682498-5	2014	It was demonstrated that UA inhibited the viability and induced apoptosis of AtT20 cells and decreased ACTH secretion.	ursolic acid	25-27	pro-opiomelanocortin-alpha	Mus musculus	103-107
24682498-8	2014	The JNK pathway participated in UA-induced mitochondrial apoptotic signaling transduction via increasing the phosphorylation and degradation of Bcl-2, which may be partly attenuated by the JNK inhibitor SP600125.	ursolic acid	32-34	mitogen-activated protein kinase 8	Mus musculus	4-7
24682498-8	2014	The JNK pathway participated in UA-induced mitochondrial apoptotic signaling transduction via increasing the phosphorylation and degradation of Bcl-2, which may be partly attenuated by the JNK inhibitor SP600125.	ursolic acid	32-34	B cell leukemia/lymphoma 2	Mus musculus	144-149
24682498-8	2014	The JNK pathway participated in UA-induced mitochondrial apoptotic signaling transduction via increasing the phosphorylation and degradation of Bcl-2, which may be partly attenuated by the JNK inhibitor SP600125.	ursolic acid	32-34	mitogen-activated protein kinase 8	Mus musculus	189-192
24682498-9	2014	In conclusion, the present study indicates that UA may be a promising candidate agent for the management of ACTH-producing pituitary adenoma.	ursolic acid	48-50	pro-opiomelanocortin-alpha	Mus musculus	108-112
25199287-0	2014	[Regulation of ursolic acid on TNF-alpha and collagen in silicotic rats].	ursolic acid	15-27	tumor necrosis factor	Rattus norvegicus	31-40
25199287-1	2014	OBJECTIVE: To explore the regulation of ursolic acid on the expressions of TNF-alpha and collagen on Silicotic Rats.	ursolic acid	40-52	tumor necrosis factor	Rattus norvegicus	75-84
25199287-10	2014	Ursolic acid had depressant effect on the contents of TNF-alpha (P &lt; 0.05).	ursolic acid	0-12	tumor necrosis factor	Rattus norvegicus	54-63
25199287-14	2014	CONCLUSIONS: Ursolic acid could decrease the expressions of TNF-alpha and collagen in the process of silicosis fibrosis.	ursolic acid	13-25	tumor necrosis factor	Rattus norvegicus	60-69
24375173-7	2014	Mechanistically, the nuclear transportation of p65 and p53 was reduced by UA administration prior to UVR exposure while the levels of p65 and p53 nuclear transportation in SM cells were sustained at a substantially higher level.	ursolic acid	74-76	RELA proto-oncogene, NF-kB subunit	Homo sapiens	47-50
24989277-8	2014	The apoptotic rate of kasumi-1 cells increased in a dose- and time-dependent ways, and the mRNA levels of AML1-ETO, KIT, MYC, CCND1, BCL2, MDM2 decreased in kasumi-1 cells treated with UA, as well as the protein levels.	ursolic acid	185-187	RUNX family transcription factor 1	Homo sapiens	106-110
24989277-9	2014	Meanwhile, UA up-regulated the mRNA and protein levels of P53 in the same manner.	ursolic acid	11-13	tumor protein p53	Homo sapiens	58-61
24815946-4	2014	p-CA and UA significantly inhibited the expression of iNOS and COX-2 in Abeta(25-35)-injured PC12 cells.	ursolic acid	9-11	nitric oxide synthase 2	Rattus norvegicus	54-58
24815946-4	2014	p-CA and UA significantly inhibited the expression of iNOS and COX-2 in Abeta(25-35)-injured PC12 cells.	ursolic acid	9-11	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	63-68
24815946-4	2014	p-CA and UA significantly inhibited the expression of iNOS and COX-2 in Abeta(25-35)-injured PC12 cells.	ursolic acid	9-11	amyloid beta precursor protein	Rattus norvegicus	72-77
24815946-5	2014	Blockade of nuclear translocation of the p65 subunit of nuclear factor kappaB (NF-kappaB) and phosphorylation of IkappaB-alpha was also observed after p-CA and UA treatment.	ursolic acid	160-162	NFKB inhibitor alpha	Rattus norvegicus	113-126
24375173-7	2014	Mechanistically, the nuclear transportation of p65 and p53 was reduced by UA administration prior to UVR exposure while the levels of p65 and p53 nuclear transportation in SM cells were sustained at a substantially higher level.	ursolic acid	74-76	tumor protein p53	Homo sapiens	55-58
24375173-9	2014	These results were consistent with reduced proliferation observed in the clonogenic assay, indicating that UA treatment enhanced the phototoxicity of UVR, by modulating the activation of p53 and NF-kappaB and initiating a mitogenic response to optical radiation that triggered mitochondria-dependent apoptosis, particularly in skin melanoma cells.	ursolic acid	107-109	tumor protein p53	Homo sapiens	187-190
24375173-9	2014	These results were consistent with reduced proliferation observed in the clonogenic assay, indicating that UA treatment enhanced the phototoxicity of UVR, by modulating the activation of p53 and NF-kappaB and initiating a mitogenic response to optical radiation that triggered mitochondria-dependent apoptosis, particularly in skin melanoma cells.	ursolic acid	107-109	nuclear factor kappa B subunit 1	Homo sapiens	195-204
25009707-4	2014	Treatment of UA enhanced platelet aggregation induced by thrombin or ADP, which was concentration-dependent in a range of 5-50 muM.	ursolic acid	13-15	coagulation factor II, thrombin	Homo sapiens	57-65
24727148-0	2014	Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-kappaB pathway.	ursolic acid	0-12	chemokine (C-C motif) ligand 4	Mus musculus	42-46
24727148-0	2014	Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-kappaB pathway.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
24727148-7	2014	Furthermore, western blot analysis showed that UA significantly decreased CYP2E1 expression levels and production of pro-inflammatory markers including TNF-alpha, IL-1beta and COX-2 in CCl(4)-treated mouse liver.	ursolic acid	47-49	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	74-80
24727148-7	2014	Furthermore, western blot analysis showed that UA significantly decreased CYP2E1 expression levels and production of pro-inflammatory markers including TNF-alpha, IL-1beta and COX-2 in CCl(4)-treated mouse liver.	ursolic acid	47-49	tumor necrosis factor	Mus musculus	152-161
24727148-7	2014	Furthermore, western blot analysis showed that UA significantly decreased CYP2E1 expression levels and production of pro-inflammatory markers including TNF-alpha, IL-1beta and COX-2 in CCl(4)-treated mouse liver.	ursolic acid	47-49	interleukin 1 beta	Mus musculus	163-171
24727148-7	2014	Furthermore, western blot analysis showed that UA significantly decreased CYP2E1 expression levels and production of pro-inflammatory markers including TNF-alpha, IL-1beta and COX-2 in CCl(4)-treated mouse liver.	ursolic acid	47-49	cytochrome c oxidase II, mitochondrial	Mus musculus	176-181
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	42-44	mitogen-activated protein kinase 14	Mus musculus	138-146
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	42-44	mitogen-activated protein kinase 1	Mus musculus	148-151
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	42-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	222-244
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	42-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	246-255
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	67-69	mitogen-activated protein kinase 14	Mus musculus	138-146
24566423-0	2014	Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of beta-catenin degradation.	ursolic acid	0-12	APC regulator of WNT signaling pathway	Homo sapiens	85-88
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	67-69	mitogen-activated protein kinase 1	Mus musculus	148-151
24566423-0	2014	Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of beta-catenin degradation.	ursolic acid	0-12	catenin beta 1	Homo sapiens	137-149
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	67-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	222-244
24566423-2	2014	Here we used a cell-based reporter system for detection of beta-catenin response transcription (CRT) to identify UA as an antagonist of the Wnt/beta-catenin pathway.	ursolic acid	113-115	catenin beta 1	Homo sapiens	59-71
24566423-2	2014	Here we used a cell-based reporter system for detection of beta-catenin response transcription (CRT) to identify UA as an antagonist of the Wnt/beta-catenin pathway.	ursolic acid	113-115	catenin beta 1	Homo sapiens	144-156
24727148-8	2014	In exploring the underlying mechanisms of UA action, we found that UA decreased the activation of mitogen-activated protein kinases (JNK, p38 MAPK, ERK), which in turn inactivated the immunoregulatory transcription factor nuclear factor kappa B (NF-kappaB) in liver of CCl(4) treated mice.	ursolic acid	67-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	246-255
24566423-3	2014	UA promoted the degradation of intracellular beta-catenin that was accompanied by its N-terminal phosphorylation at Ser33/37/Thr41 residues, marking it for proteasomal degradation.	ursolic acid	0-2	catenin beta 1	Homo sapiens	45-57
24727148-9	2014	In conclusion, these results suggested that the inhibition of CCl(4)-induced inflammation by UA is due at least in part to its anti-oxidant activity and its ability to modulate the MAPK and NF-kappaB signaling pathway.	ursolic acid	93-95	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	190-199
24566423-4	2014	Consistently, UA down-regulated the intracellular beta-catenin level in colon cancer cells with inactivating mutations of adenomatous polyposis coli (APC).	ursolic acid	14-16	catenin beta 1	Homo sapiens	50-62
24566423-4	2014	Consistently, UA down-regulated the intracellular beta-catenin level in colon cancer cells with inactivating mutations of adenomatous polyposis coli (APC).	ursolic acid	14-16	APC regulator of WNT signaling pathway	Homo sapiens	150-153
24740400-0	2014	Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.	ursolic acid	0-12	CREB regulated transcription coactivator 1	Mus musculus	41-47
24566423-5	2014	In addition, UA repressed the expression of beta-catenin/T-cell factor (TCF)-dependent genes, thereby inhibiting cell proliferation in colon cancer cells.	ursolic acid	13-15	hepatocyte nuclear factor 4 alpha	Homo sapiens	44-70
24566423-5	2014	In addition, UA repressed the expression of beta-catenin/T-cell factor (TCF)-dependent genes, thereby inhibiting cell proliferation in colon cancer cells.	ursolic acid	13-15	hepatocyte nuclear factor 4 alpha	Homo sapiens	72-75
24566423-6	2014	The functional group analysis revealed that the major structural requirements for UA-mediated beta-catenin degradation are a carboxyl group at position 17 and a methyl group at position 19.	ursolic acid	82-84	catenin beta 1	Homo sapiens	94-106
24566423-8	2014	Our findings suggest that UA and CA exert their anticancer activities against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of beta-catenin.	ursolic acid	26-28	catenin beta 1	Homo sapiens	183-195
24740400-0	2014	Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	41-45
24847381-2	2014	UA suppresses proliferation and induces apoptosis in a variety of tumor cells via inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB).	ursolic acid	0-2	nuclear factor kappa B subunit 1	Homo sapiens	160-168
24740400-3	2014	Here we show that UA inhibits leucine-induced activation of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway in C2C12 myotubes.	ursolic acid	18-20	CREB regulated transcription coactivator 1	Mus musculus	107-113
24548018-2	2014	In the current contribution, our central goal was to integratively dissect the biointeraction of two typical triterpenoids, ursolic acid and oleanolic acid, by the most fundamental macromolecule bovine serum albumin (BSA) by employing molecular modeling, steady state and time-resolved fluorescence, and circular dichroism spectra at the molecular scale.	ursolic acid	124-136	albumin	Homo sapiens	202-215
24740400-4	2014	The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators.	ursolic acid	4-6	CREB regulated transcription coactivator 1	Mus musculus	30-36
24740400-4	2014	The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators.	ursolic acid	4-6	AKT serine/threonine kinase 1	Homo sapiens	55-58
24740400-4	2014	The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators.	ursolic acid	4-6	Ras homolog, mTORC1 binding	Homo sapiens	136-140
24740400-4	2014	The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators.	ursolic acid	4-6	CREB regulated transcription coactivator 1	Mus musculus	183-189
24740400-4	2014	The UA-mediated inhibition of mTORC1 is independent of Akt, tuberous sclerosis complex 1/2 (TSC1/2), and Ras homolog enriched in brain (Rheb), suggesting that UA negatively regulates mTORC1 signaling by targeting at a site downstream of these mTOR regulators.	ursolic acid	4-6	mechanistic target of rapamycin kinase	Homo sapiens	30-34
24740400-5	2014	UA treatment had no effect on the interaction between mTOR and its activator Raptor or inhibitor Deptor, but suppressed the binding of RagB to Raptor and inhibited leucine-induced mTOR lysosomal localization.	ursolic acid	0-2	Ras related GTP binding B	Homo sapiens	135-139
24740400-5	2014	UA treatment had no effect on the interaction between mTOR and its activator Raptor or inhibitor Deptor, but suppressed the binding of RagB to Raptor and inhibited leucine-induced mTOR lysosomal localization.	ursolic acid	0-2	regulatory associated protein of MTOR complex 1	Homo sapiens	143-149
24740400-5	2014	UA treatment had no effect on the interaction between mTOR and its activator Raptor or inhibitor Deptor, but suppressed the binding of RagB to Raptor and inhibited leucine-induced mTOR lysosomal localization.	ursolic acid	0-2	mechanistic target of rapamycin kinase	Homo sapiens	180-184
24740400-6	2014	Taken together, our study identifies UA as a direct negative regulator of the mTORC1 signaling pathway and suggests a novel mechanism by which UA exerts its beneficial function.	ursolic acid	37-39	CREB regulated transcription coactivator 1	Mus musculus	78-84
24740400-6	2014	Taken together, our study identifies UA as a direct negative regulator of the mTORC1 signaling pathway and suggests a novel mechanism by which UA exerts its beneficial function.	ursolic acid	143-145	CREB regulated transcription coactivator 1	Mus musculus	78-84
24413389-0	2014	Crucial role of heme oxygenase-1 in the sensitivity of acute myeloid leukemia cell line Kasumi-1 to ursolic acid.	ursolic acid	100-112	heme oxygenase 1	Homo sapiens	16-32
24413389-4	2014	HO-1 in Kasumi-1 cells was upregulated by being treated with low-dose rather than high-dose UA.	ursolic acid	92-94	heme oxygenase 1	Homo sapiens	0-4
24413389-5	2014	Inhibition of HO-1 by zinc protoporphyrin (ZnPP) IX sensitized Kasumi-1 cells to UA, and the apoptotic rate was close to that induced by Ara-C (P&lt;0.01).	ursolic acid	81-83	heme oxygenase 1	Homo sapiens	14-18
24413389-7	2014	After silencing HO-1 by siRNA transfection with lentivirus, the cells" proliferation induced by UA was increased as it was by Ara-C.	ursolic acid	96-98	heme oxygenase 1	Homo sapiens	16-20
24413389-10	2014	AML-M2 can feasibly be treated by target-inhibiting HO-1 that enhances the antileukemia effects of UA in vitro and in vivo.	ursolic acid	99-101	heme oxygenase 1	Homo sapiens	52-56
24762997-1	2014	The study was aimed to investigate the inducing effect of ursolic acid (UA) on the apoptosis of human T-cell leukemia/lymphoma (Jurkat), and whether the regulation of PTEN involved in the effect of UA on Jurkat cells.	ursolic acid	198-200	phosphatase and tensin homolog	Homo sapiens	167-171
24762997-9	2014	It is concluded that UA may induce Jurkat cell apoptosis by up-regulating the PTEN mRNA expression.	ursolic acid	21-23	phosphatase and tensin homolog	Homo sapiens	78-82
24489777-8	2014	Knocking down PPAR-alpha significantly inhibited the anti-steatosis role of UA in vitro.	ursolic acid	76-78	peroxisome proliferator activated receptor alpha	Rattus norvegicus	14-24
24649404-0	2014	Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum.	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	125-158
24649404-2	2014	Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1alpha (IL-1alpha).	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	75-108
24649404-2	2014	Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1alpha (IL-1alpha).	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	110-116
24649404-2	2014	Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1alpha (IL-1alpha).	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	133-151
24649404-2	2014	Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1alpha (IL-1alpha).	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	153-162
24649404-4	2014	Ursolic acid markedly inhibited the IL-1alpha-induced cell-surface ICAM-1 expression in human cancer cell lines and human umbilical vein endothelial cells.	ursolic acid	0-12	interleukin 1 alpha	Homo sapiens	36-45
24649404-4	2014	Ursolic acid markedly inhibited the IL-1alpha-induced cell-surface ICAM-1 expression in human cancer cell lines and human umbilical vein endothelial cells.	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	67-73
24649404-5	2014	By contrast, ursolic acid exerted weak inhibitory effects on the IL-1alpha-induced ICAM-1 expression at the protein level.	ursolic acid	13-25	interleukin 1 alpha	Homo sapiens	65-74
24649404-5	2014	By contrast, ursolic acid exerted weak inhibitory effects on the IL-1alpha-induced ICAM-1 expression at the protein level.	ursolic acid	13-25	intercellular adhesion molecule 1	Homo sapiens	83-89
24649404-6	2014	Surprisingly, we found that ursolic acid decreased the apparent molecular weight of ICAM-1 and altered the structures of N-linked oligosaccharides bound to ICAM-1.	ursolic acid	28-40	intercellular adhesion molecule 1	Homo sapiens	84-90
24649404-6	2014	Surprisingly, we found that ursolic acid decreased the apparent molecular weight of ICAM-1 and altered the structures of N-linked oligosaccharides bound to ICAM-1.	ursolic acid	28-40	intercellular adhesion molecule 1	Homo sapiens	156-162
24649404-7	2014	Ursolic acid induced the accumulation of ICAM-1 in the endoplasmic reticulum, which was linked mainly to high-mannose-type glycans.	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	41-47
24649404-9	2014	Thus, our results reveal that ursolic acid inhibits intracellular trafficking of proteins and induces the accumulation of ICAM-1 linked to high-mannose-type glycans in the endoplasmic reticulum.	ursolic acid	30-42	intercellular adhesion molecule 1	Homo sapiens	122-128
24197982-0	2014	Mitochondrial translocation of cofilin-1 promotes apoptosis of gastric cancer BGC-823 cells induced by ursolic acid.	ursolic acid	103-115	cofilin 1	Homo sapiens	31-40
24197982-4	2014	In our present study, we found in apoptotic gastric cancer BGC-823 cells induced by ursolic acid that a translocation of cofilin-1 protein from the cytoplasm to the mitochondria promoted the release of cytochrome c from the mitochondria to the cytoplasm, thereby activating the caspase cascade and finally inducing gastric cancer cell apoptosis.	ursolic acid	84-96	cofilin 1	Homo sapiens	121-130
24197982-4	2014	In our present study, we found in apoptotic gastric cancer BGC-823 cells induced by ursolic acid that a translocation of cofilin-1 protein from the cytoplasm to the mitochondria promoted the release of cytochrome c from the mitochondria to the cytoplasm, thereby activating the caspase cascade and finally inducing gastric cancer cell apoptosis.	ursolic acid	84-96	cytochrome c, somatic	Homo sapiens	202-214
24489777-11	2014	CONCLUSIONS/SIGNIFICANCE: These results demonstrated that UA effectively ameliorated HFD-induced hepatic steatosis through a PPAR-alpha involved pathway, via improving key enzymes in the controlling of lipids metabolism.	ursolic acid	58-60	peroxisome proliferator activated receptor alpha	Rattus norvegicus	125-135
24334003-0	2014	Accentuation of ursolic acid on muscarinic receptor-induced ANP secretion in beating rabbit atria.	ursolic acid	16-28	natriuretic peptides A	Oryctolagus cuniculus	60-63
24334003-1	2014	AIMS: Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria.	ursolic acid	6-18	natriuretic peptides A	Oryctolagus cuniculus	63-89
24334003-1	2014	AIMS: Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria.	ursolic acid	6-18	natriuretic peptides A	Oryctolagus cuniculus	91-94
24334003-2	2014	MAIN METHODS: The present study was designed to clarify the regulatory effects of ursolic acid on the beta-adrenergic or muscarinic receptor-mediated changes in ANP secretory and contractile function allowing measurement of atrial dynamics such as pulse pressure, stroke volume, and cAMP efflux in isolated perfused beating rabbit atria.	ursolic acid	82-94	natriuretic peptides A	Oryctolagus cuniculus	161-164
24334003-3	2014	KEY FINDINGS: Pretreatment with ursolic acid significantly attenuated the isoproterenol (beta-adrenergic agonist)-induced decrease in ANP secretion and increases in cAMP levels and atrial dynamics.	ursolic acid	32-44	natriuretic peptides A	Oryctolagus cuniculus	134-137
24334003-4	2014	Interestingly, ursolic acid concentration-dependently accentuated the acetylcholine-induced increase in ANP secretion and decrease in pulse pressure in the presence of isoproterenol (p&lt;0.001).	ursolic acid	15-27	natriuretic peptides A	Oryctolagus cuniculus	104-107
24334003-5	2014	These findings indicate that acetylcholine-induced increase in ANP secretion is potentiated by ursolic acid; furthermore, acetylcholine-induced decrease in atrial dynamics is also potentiated by ursolic acid, suggesting that ursolic acid regulates muscarinic receptor-mediated secretory and contractile responses in perfused beating rabbit atria.	ursolic acid	95-107	natriuretic peptides A	Oryctolagus cuniculus	63-66
25520072-0	2014	Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1.	ursolic acid	0-12	sarcoglycan beta	Homo sapiens	35-38
24494201-0	2014	Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4.	ursolic acid	0-12	NADPH oxidase 4	Mus musculus	120-124
24494201-4	2014	UA protected THP-1 monocytes and peritoneal macrophages against metabolic priming and prevented their hyper-reactivity to MCP-1.	ursolic acid	0-2	GLI family zinc finger 2	Homo sapiens	13-18
24494201-4	2014	UA protected THP-1 monocytes and peritoneal macrophages against metabolic priming and prevented their hyper-reactivity to MCP-1.	ursolic acid	0-2	mast cell protease 1	Mus musculus	122-127
24494201-6	2014	UA also restored MAPK phosphatase-1 (MKP1) protein expression and phosphatase activity, decreased by metabolic priming, and normalized p38 MAPK activation.	ursolic acid	0-2	dual specificity phosphatase 1	Mus musculus	17-35
24494201-6	2014	UA also restored MAPK phosphatase-1 (MKP1) protein expression and phosphatase activity, decreased by metabolic priming, and normalized p38 MAPK activation.	ursolic acid	0-2	dual specificity phosphatase 1	Mus musculus	37-41
24494201-6	2014	UA also restored MAPK phosphatase-1 (MKP1) protein expression and phosphatase activity, decreased by metabolic priming, and normalized p38 MAPK activation.	ursolic acid	0-2	mitogen-activated protein kinase 14	Mus musculus	135-138
24494201-8	2014	However, the induction of Nox4 by metabolic stress, required for metabolic priming, was inhibited by UA in both THP-1 monocytes and peritoneal macrophages.	ursolic acid	101-103	NADPH oxidase 4	Mus musculus	26-30
24494201-8	2014	However, the induction of Nox4 by metabolic stress, required for metabolic priming, was inhibited by UA in both THP-1 monocytes and peritoneal macrophages.	ursolic acid	101-103	GLI family zinc finger 2	Homo sapiens	112-117
24494201-9	2014	CONCLUSION: UA protects THP-1 monocytes against dysfunction by suppressing metabolic stress-induced Nox4 expression, thereby preventing the Nox4-dependent dysregulation of redox-sensitive processes, including actin turnover and MAPK-signaling, two key processes that control monocyte migration and adhesion.	ursolic acid	12-14	GLI family zinc finger 2	Homo sapiens	24-29
24494201-9	2014	CONCLUSION: UA protects THP-1 monocytes against dysfunction by suppressing metabolic stress-induced Nox4 expression, thereby preventing the Nox4-dependent dysregulation of redox-sensitive processes, including actin turnover and MAPK-signaling, two key processes that control monocyte migration and adhesion.	ursolic acid	12-14	NADPH oxidase 4	Mus musculus	100-104
24494201-9	2014	CONCLUSION: UA protects THP-1 monocytes against dysfunction by suppressing metabolic stress-induced Nox4 expression, thereby preventing the Nox4-dependent dysregulation of redox-sensitive processes, including actin turnover and MAPK-signaling, two key processes that control monocyte migration and adhesion.	ursolic acid	12-14	NADPH oxidase 4	Mus musculus	140-144
25520072-0	2014	Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1.	ursolic acid	0-12	phosphatase and tensin homolog	Homo sapiens	78-82
25520072-0	2014	Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1.	ursolic acid	0-12	cofilin 1	Homo sapiens	123-132
25520072-4	2014	Here, we report that ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	21-33	sarcoglycan beta	Homo sapiens	88-91
25520072-4	2014	Here, we report that ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	35-37	sarcoglycan beta	Homo sapiens	88-91
25520072-5	2014	Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis.	ursolic acid	100-102	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	46-51
25520072-5	2014	Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis.	ursolic acid	100-102	phosphatase and tensin homolog	Homo sapiens	52-56
25520072-5	2014	Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis.	ursolic acid	100-102	cofilin 1	Homo sapiens	143-152
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	104-109
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	phosphatase and tensin homolog	Homo sapiens	114-118
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	cofilin 1	Homo sapiens	154-163
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	cytochrome c, somatic	Homo sapiens	207-219
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	caspase 3	Homo sapiens	235-244
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	caspase 9	Homo sapiens	249-258
25520072-6	2014	These findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of ROCK1 and PTEN, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer SGC-7901 cells.	ursolic acid	52-64	sarcoglycan beta	Homo sapiens	309-312
24484591-0	2014	Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	56-59
24484591-5	2014	RESULTS: It was found that UA could induce the differentiation of U937cells and Akt-activity was significantly increased during differentiation.	ursolic acid	27-29	AKT serine/threonine kinase 1	Homo sapiens	80-83
24484591-6	2014	Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA.	ursolic acid	103-105	AKT serine/threonine kinase 1	Homo sapiens	31-34
24484591-7	2014	CONCLUSION: UA could induce the differentiation of U937 cells by activating the PI3K/Akt pathway, and it could be a potential candidate as a differentiation-inducing agent for the therapy of leukemia.	ursolic acid	12-14	AKT serine/threonine kinase 1	Homo sapiens	85-88
23737395-8	2013	Wortmannin, an inhibitor of autophagy, and a small interfering RNA (siRNA) for autophagy-related genes (Atg5) reduced LC3II and simultaneously increased the survival of TC-1 cells treated with UA.	ursolic acid	193-195	autophagy related 5	Mus musculus	104-108
26629938-4	2014	Our results showed the increase of the percent of apoptotic cells and G1 phase, the inhibition of cell migrations well as the decrease of the expression of Bax, caspase 3 and Bcl-2 in BGC-823 cells after the treatment with UA.	ursolic acid	223-225	BCL2 associated X, apoptosis regulator	Homo sapiens	156-159
26629938-4	2014	Our results showed the increase of the percent of apoptotic cells and G1 phase, the inhibition of cell migrations well as the decrease of the expression of Bax, caspase 3 and Bcl-2 in BGC-823 cells after the treatment with UA.	ursolic acid	223-225	caspase 3	Homo sapiens	161-170
26629938-4	2014	Our results showed the increase of the percent of apoptotic cells and G1 phase, the inhibition of cell migrations well as the decrease of the expression of Bax, caspase 3 and Bcl-2 in BGC-823 cells after the treatment with UA.	ursolic acid	223-225	BCL2 apoptosis regulator	Homo sapiens	175-180
24376583-7	2013	The HNE inhibitory activity of ursolic acid was further verified using a mouse model of acute smoke-induced lung inflammation.	ursolic acid	31-43	elastase, neutrophil expressed	Homo sapiens	4-7
23737395-0	2013	Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy.	ursolic acid	0-12	autophagy related 5	Mus musculus	52-56
23737395-5	2013	We found that UA increased punctate staining of light chain 3 (LC3), which is an autophagy marker.	ursolic acid	14-16	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	63-66
24881958-0	2014	Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and suppression of ERK1/2 MAPK in HeLa cells.	ursolic acid	0-12	mitogen-activated protein kinase 3	Homo sapiens	90-96
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	cytochrome c, somatic	Homo sapiens	134-146
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	caspase 9	Homo sapiens	162-178
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	BCL2 apoptosis regulator	Homo sapiens	193-198
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	BCL2 like 1	Homo sapiens	203-209
24881958-3	2014	Here, we reported that UA induced apoptosis through the mitochondrial intrinsic pathway in HeLa cells, as shown by release of cytosol cytochrome c, activation of caspase-9 and -3, reduction of Bcl-2 and Bcl-xL, and increase of Bax and Bak.	ursolic acid	23-25	BCL2 associated X, apoptosis regulator	Homo sapiens	227-230
24881958-4	2014	UA down-regulated the phosphorylation of ERK1/2 and p38, whereas phosphorylation of JNK was unchanged.	ursolic acid	0-2	mitogen-activated protein kinase 3	Homo sapiens	41-47
24881958-4	2014	UA down-regulated the phosphorylation of ERK1/2 and p38, whereas phosphorylation of JNK was unchanged.	ursolic acid	0-2	mitogen-activated protein kinase 1	Homo sapiens	52-55
24881958-6	2014	U0126 markedly increased UA-induced the Bax/Bcl-2 ratio, the increase of cytosol cytochrome c, and the levels of cleaved caspase-3, but SB203580 had little effects on the above characters, suggesting the ERK1/2 signaling pathway is required for apoptosis.	ursolic acid	25-27	BCL2 associated X, apoptosis regulator	Homo sapiens	40-43
24881958-6	2014	U0126 markedly increased UA-induced the Bax/Bcl-2 ratio, the increase of cytosol cytochrome c, and the levels of cleaved caspase-3, but SB203580 had little effects on the above characters, suggesting the ERK1/2 signaling pathway is required for apoptosis.	ursolic acid	25-27	BCL2 apoptosis regulator	Homo sapiens	44-49
24881958-6	2014	U0126 markedly increased UA-induced the Bax/Bcl-2 ratio, the increase of cytosol cytochrome c, and the levels of cleaved caspase-3, but SB203580 had little effects on the above characters, suggesting the ERK1/2 signaling pathway is required for apoptosis.	ursolic acid	25-27	cytochrome c, somatic	Homo sapiens	81-93
24881958-6	2014	U0126 markedly increased UA-induced the Bax/Bcl-2 ratio, the increase of cytosol cytochrome c, and the levels of cleaved caspase-3, but SB203580 had little effects on the above characters, suggesting the ERK1/2 signaling pathway is required for apoptosis.	ursolic acid	25-27	mitogen-activated protein kinase 3	Homo sapiens	204-210
24881958-7	2014	Furthermore, UA up-regulated DUSP 1, 2, 4, 5, 6, 7, 9, and 10 mRNA expressions, which may be a clue for the role of dephosphorylation of ERK1/2 and p38.	ursolic acid	13-15	mitogen-activated protein kinase 3	Homo sapiens	137-143
24881958-7	2014	Furthermore, UA up-regulated DUSP 1, 2, 4, 5, 6, 7, 9, and 10 mRNA expressions, which may be a clue for the role of dephosphorylation of ERK1/2 and p38.	ursolic acid	13-15	mitogen-activated protein kinase 1	Homo sapiens	148-151
24881958-8	2014	These data suggested that the apoptotic mechanism of UA treatment in HeLa cells was through the mitochondrial intrinsic pathway and closely associated with the suppression of the ERK1/2 signaling pathway.	ursolic acid	53-55	mitogen-activated protein kinase 3	Homo sapiens	179-185
23737395-9	2013	We also found that LC3II was significantly reduced and that survival was increased in Atg5-/- mouse embryonic fibroblast (MEF) cells compared to Atg5+/+ MEF cells under UA treatment.	ursolic acid	169-171	autophagy related 5	Mus musculus	86-90
23737395-12	2013	It is Atg5 rather than BECN1 that plays a crucial role in UA-induced autophagic cell death in TC-1 cells.	ursolic acid	58-60	autophagy related 5	Mus musculus	6-10
23737395-12	2013	It is Atg5 rather than BECN1 that plays a crucial role in UA-induced autophagic cell death in TC-1 cells.	ursolic acid	58-60	beclin 1, autophagy related	Mus musculus	23-28
23737395-14	2013	Furthermore, regulation of Atg5 may improve the efficacy of UA in cancer treatment.	ursolic acid	60-62	autophagy related 5	Mus musculus	27-31
24051192-15	2013	UA downregulated VEGF &amp; iNOS expression whereas bax and caspase-3 expressions were upregulated suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3 and downregulation of VEGF.	ursolic acid	0-2	B cell leukemia/lymphoma 2	Mus musculus	181-186
24071474-5	2013	Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells.	ursolic acid	31-43	tumor protein p53	Homo sapiens	70-73
24071474-5	2013	Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells.	ursolic acid	31-43	nuclear factor kappa B subunit 1	Homo sapiens	75-84
24071474-5	2013	Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells.	ursolic acid	31-43	BCL2 associated X, apoptosis regulator	Homo sapiens	89-92
24071474-5	2013	Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells.	ursolic acid	31-43	transcription elongation factor A like 1	Homo sapiens	124-127
24071474-5	2013	Above results demonstrate that ursolic acid induces the activation of p53, NF-kappaB and Bax, leading to the enhancement of p21 transcriptional activity and activation of Caspase-9 and -3, thus finally induces apoptosis of SW480 cells.	ursolic acid	31-43	caspase 9	Homo sapiens	171-187
24051192-15	2013	UA downregulated VEGF &amp; iNOS expression whereas bax and caspase-3 expressions were upregulated suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3 and downregulation of VEGF.	ursolic acid	0-2	vascular endothelial growth factor A	Mus musculus	17-21
24051192-15	2013	UA downregulated VEGF &amp; iNOS expression whereas bax and caspase-3 expressions were upregulated suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3 and downregulation of VEGF.	ursolic acid	0-2	nitric oxide synthase 2, inducible	Mus musculus	28-32
24465045-11	2013	Compared with untreated diabetic rats, UA treatment lowered urine albumin excretion, renal oxidative stress level, NF-kappaB activity, and P-selectin expression.	ursolic acid	39-41	selectin P	Rattus norvegicus	139-149
24071474-0	2013	Ursolic acid induces apoptosis of SW480 cells via p53 activation.	ursolic acid	0-12	tumor protein p53	Homo sapiens	50-53
24071474-3	2013	Both the expression level and transcriptional activity of p53, an apoptotic protein, were remarkably up-regulated in cells treated with ursolic acid compared to blank group.	ursolic acid	136-148	tumor protein p53	Homo sapiens	58-61
24071474-4	2013	In addition, the expression levels of p-p53, acetyl-p53, NF-kappaB, p-p21, Bax, Caspase-3 and Caspase-9, apoptotic proteins, were increased in cells treated with ursolic acid compared to blank group.	ursolic acid	162-174	nuclear factor kappa B subunit 1	Homo sapiens	57-66
24071474-4	2013	In addition, the expression levels of p-p53, acetyl-p53, NF-kappaB, p-p21, Bax, Caspase-3 and Caspase-9, apoptotic proteins, were increased in cells treated with ursolic acid compared to blank group.	ursolic acid	162-174	caspase 3	Homo sapiens	80-89
24071474-4	2013	In addition, the expression levels of p-p53, acetyl-p53, NF-kappaB, p-p21, Bax, Caspase-3 and Caspase-9, apoptotic proteins, were increased in cells treated with ursolic acid compared to blank group.	ursolic acid	162-174	caspase 9	Homo sapiens	94-103
24051192-15	2013	UA downregulated VEGF &amp; iNOS expression whereas bax and caspase-3 expressions were upregulated suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3 and downregulation of VEGF.	ursolic acid	0-2	caspase 3	Mus musculus	198-207
24051192-15	2013	UA downregulated VEGF &amp; iNOS expression whereas bax and caspase-3 expressions were upregulated suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3 and downregulation of VEGF.	ursolic acid	0-2	vascular endothelial growth factor A	Mus musculus	230-234
23325562-6	2013	Conversely, AMPK inhibitor compound C or GSK3beta inhibitor SB216763 blocked the cleavages of PARP and caspase 3 induced by ursolic acid in HepG2 cells.	ursolic acid	124-136	glycogen synthase kinase 3 beta	Homo sapiens	41-49
24042330-9	2013	Moreover, UA treatment inhibited the expression of critical angiogenic factors, such as VEGF-A and bFGF.	ursolic acid	10-12	vascular endothelial growth factor A	Mus musculus	88-94
24042330-9	2013	Moreover, UA treatment inhibited the expression of critical angiogenic factors, such as VEGF-A and bFGF.	ursolic acid	10-12	fibroblast growth factor 2	Mus musculus	99-103
24042330-10	2013	Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways.	ursolic acid	13-15	sonic hedgehog	Mus musculus	45-59
24042330-10	2013	Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways.	ursolic acid	13-15	sonic hedgehog	Mus musculus	61-64
24042330-10	2013	Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways.	ursolic acid	13-15	signal transducer and activator of transcription 3	Mus musculus	67-72
24042330-10	2013	Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways.	ursolic acid	13-15	thymoma viral proto-oncogene 1	Mus musculus	74-77
24042330-10	2013	Furthermore, UA suppressed the activation of sonic hedgehog (SHH), STAT3, Akt and p70S6K pathways.	ursolic acid	13-15	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	82-88
23325562-2	2013	Thus, in the present study, the roles of AMP-activated protein kinase (AMPK) and glycogen synthase kinase 3 beta (GSK3beta) were examined in ursolic acid induced apoptosis in HepG2 hepatocellular carcinoma cells.	ursolic acid	141-153	glycogen synthase kinase 3 beta	Homo sapiens	81-112
23325562-2	2013	Thus, in the present study, the roles of AMP-activated protein kinase (AMPK) and glycogen synthase kinase 3 beta (GSK3beta) were examined in ursolic acid induced apoptosis in HepG2 hepatocellular carcinoma cells.	ursolic acid	141-153	glycogen synthase kinase 3 beta	Homo sapiens	114-122
23325562-3	2013	Ursolic acid significantly exerted cytotoxicity, increased the sub-G1 population and the number of ethidium homodimer and terminal deoxynucleotidyl transferase(TdT) mediated dUTP nick end labeling positive cells in HepG2 cells.	ursolic acid	0-12	DNA nucleotidylexotransferase	Homo sapiens	160-163
23325562-4	2013	Also, ursolic acid enhanced the cleavages of poly-ADP-ribose polymerase (PARP) and caspase3, attenuated the expression of astrocyte elevated gene (AEG1) and survivin in HepG2 cells.	ursolic acid	6-18	poly(ADP-ribose) polymerase 1	Homo sapiens	45-71
23325562-4	2013	Also, ursolic acid enhanced the cleavages of poly-ADP-ribose polymerase (PARP) and caspase3, attenuated the expression of astrocyte elevated gene (AEG1) and survivin in HepG2 cells.	ursolic acid	6-18	poly(ADP-ribose) polymerase 1	Homo sapiens	73-77
23325562-4	2013	Also, ursolic acid enhanced the cleavages of poly-ADP-ribose polymerase (PARP) and caspase3, attenuated the expression of astrocyte elevated gene (AEG1) and survivin in HepG2 cells.	ursolic acid	6-18	caspase 3	Homo sapiens	83-91
23325562-4	2013	Also, ursolic acid enhanced the cleavages of poly-ADP-ribose polymerase (PARP) and caspase3, attenuated the expression of astrocyte elevated gene (AEG1) and survivin in HepG2 cells.	ursolic acid	6-18	metadherin	Homo sapiens	147-151
23325562-5	2013	Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells.	ursolic acid	15-27	glycogen synthase kinase 3 beta	Homo sapiens	130-138
23325562-5	2013	Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells.	ursolic acid	15-27	AKT serine/threonine kinase 1	Homo sapiens	221-224
23325562-5	2013	Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells.	ursolic acid	15-27	mechanistic target of rapamycin kinase	Homo sapiens	229-233
23325562-6	2013	Conversely, AMPK inhibitor compound C or GSK3beta inhibitor SB216763 blocked the cleavages of PARP and caspase 3 induced by ursolic acid in HepG2 cells.	ursolic acid	124-136	poly(ADP-ribose) polymerase 1	Homo sapiens	94-98
23325562-5	2013	Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells.	ursolic acid	174-186	AKT serine/threonine kinase 1	Homo sapiens	221-224
23325562-5	2013	Interestingly, ursolic acid increased the phosphorylation of AMPK and coenzyme A carboxylase and also enhanced phosphorylation of GSK3beta at inactive form serine 9, whereas ursolic acid attenuated the phosphorylation of AKT and mTOR in HepG2 cells.	ursolic acid	174-186	mechanistic target of rapamycin kinase	Homo sapiens	229-233
23325562-6	2013	Conversely, AMPK inhibitor compound C or GSK3beta inhibitor SB216763 blocked the cleavages of PARP and caspase 3 induced by ursolic acid in HepG2 cells.	ursolic acid	124-136	caspase 3	Homo sapiens	103-112
23325562-7	2013	Furthermore, proteosomal inhibitor MG132 suppressed AMPK activation, GSK3beta phosphorylation, cleaved PARP and deceased AEG-1 induced by ursolic acid in HepG2 cells.	ursolic acid	138-150	metadherin	Homo sapiens	121-126
23325562-8	2013	Overall, our findings suggest that ursolic acid induced apoptosis in HepG2 cells via AMPK activation and GSK3beta phosphorylation as a potent chemopreventive agent.	ursolic acid	35-47	glycogen synthase kinase 3 beta	Homo sapiens	105-113
24168697-10	2013	The plant extract, compounds ursolic acid and myricitrin (commercially acquired) significantly inhibited the release of inflammatory cytokines IL 8 and TNF alpha by suppressing them by 74 - 99%.	ursolic acid	29-41	C-X-C motif chemokine ligand 8	Homo sapiens	143-147
24168697-10	2013	The plant extract, compounds ursolic acid and myricitrin (commercially acquired) significantly inhibited the release of inflammatory cytokines IL 8 and TNF alpha by suppressing them by 74 - 99%.	ursolic acid	29-41	tumor necrosis factor	Homo sapiens	152-161
24122993-0	2013	Ursolic acid inhibits the growth of colon cancer-initiating cells by targeting STAT3.	ursolic acid	0-12	signal transducer and activator of transcription 3	Homo sapiens	79-84
24122993-2	2013	In the present study we tested the efficacy of inhibiting STAT3 signaling in human colon cancer-initiating cells by ursolic acid (UA), which exists widely in fruits and herbs.	ursolic acid	116-128	signal transducer and activator of transcription 3	Homo sapiens	58-63
24122993-2	2013	In the present study we tested the efficacy of inhibiting STAT3 signaling in human colon cancer-initiating cells by ursolic acid (UA), which exists widely in fruits and herbs.	ursolic acid	130-132	signal transducer and activator of transcription 3	Homo sapiens	58-63
24122993-3	2013	RESULTS: Our data demonstrated that UA inhibited STAT3 phosphorylation, and induced caspase-3 cleavage of ALDH(+)/CD133(+) colon cancer-initiating cells.	ursolic acid	36-38	signal transducer and activator of transcription 3	Homo sapiens	49-54
24122993-3	2013	RESULTS: Our data demonstrated that UA inhibited STAT3 phosphorylation, and induced caspase-3 cleavage of ALDH(+)/CD133(+) colon cancer-initiating cells.	ursolic acid	36-38	caspase 3	Homo sapiens	84-93
24122993-5	2013	UA also inhibited the activation of STAT3 induced by interleukin-6 in DLD-1 colon cancer cells.	ursolic acid	0-2	signal transducer and activator of transcription 3	Homo sapiens	36-41
24122993-5	2013	UA also inhibited the activation of STAT3 induced by interleukin-6 in DLD-1 colon cancer cells.	ursolic acid	0-2	interleukin 6	Homo sapiens	53-66
24122993-8	2013	UA, a dietary agent, might offer an effective approach for colorectal carcinoma prevention by inhibiting persistently activated STAT3 in cancer stem cells.	ursolic acid	0-2	signal transducer and activator of transcription 3	Homo sapiens	128-133
23932918-0	2013	Ursolic acid from Agastache mexicana aerial parts produces antinociceptive activity involving TRPV1 receptors, cGMP and a serotonergic synergism.	ursolic acid	0-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	94-99
22549898-0	2013	Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.	ursolic acid	58-70	glucose-6-phosphate isomerase 1	Mus musculus	19-22
22549898-4	2013	Only UA efficiently suppressed the AMF/PGI-induced Huh7 cell migration and MMP-3 secretion.	ursolic acid	5-7	glucose-6-phosphate isomerase	Homo sapiens	39-42
22549898-4	2013	Only UA efficiently suppressed the AMF/PGI-induced Huh7 cell migration and MMP-3 secretion.	ursolic acid	5-7	MIR7-3 host gene	Homo sapiens	51-55
22549898-4	2013	Only UA efficiently suppressed the AMF/PGI-induced Huh7 cell migration and MMP-3 secretion.	ursolic acid	5-7	matrix metallopeptidase 3	Homo sapiens	75-80
22549898-5	2013	Additionally, UA inhibited the AMF/PGI-mediated protection against TGF-beta-induced apoptosis in Hep3B cells, whereas OA, tangeretin, and nobiletin had no effect.	ursolic acid	14-16	glucose-6-phosphate isomerase	Homo sapiens	35-38
22549898-6	2013	In Huh7 cells and tumor tissues, UA disrupted the Src/RhoA/PI 3-kinase signaling and complex formation induced by AMF/PGI.	ursolic acid	33-35	MIR7-3 host gene	Homo sapiens	3-7
22549898-6	2013	In Huh7 cells and tumor tissues, UA disrupted the Src/RhoA/PI 3-kinase signaling and complex formation induced by AMF/PGI.	ursolic acid	33-35	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-53
22549898-6	2013	In Huh7 cells and tumor tissues, UA disrupted the Src/RhoA/PI 3-kinase signaling and complex formation induced by AMF/PGI.	ursolic acid	33-35	ras homolog family member A	Homo sapiens	54-58
22549898-6	2013	In Huh7 cells and tumor tissues, UA disrupted the Src/RhoA/PI 3-kinase signaling and complex formation induced by AMF/PGI.	ursolic acid	33-35	glucose-6-phosphate isomerase	Homo sapiens	118-121
22549898-7	2013	In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation.	ursolic acid	21-23	glucose-6-phosphate isomerase	Homo sapiens	52-55
22549898-7	2013	In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation.	ursolic acid	21-23	AKT serine/threonine kinase 1	Homo sapiens	113-116
22549898-7	2013	In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation.	ursolic acid	21-23	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	118-121
22549898-7	2013	In the Hep3B system, UA dramatically suppressed AMF/PGI-induced anti-apoptotic signaling transmission, including Akt, p85, Bad, and Stat3 phosphorylation.	ursolic acid	21-23	signal transducer and activator of transcription 3	Homo sapiens	132-137
22549898-8	2013	AMF/PGI enhances tumor growth, angiogenesis, and pulmonary metastasis in mice, which is correlated with its enzymatic activity, and critically, UA intraperitoneal injection reduces the tumorigenesis in vivo, enhances apoptosis in tumor tissues and also prolongs mouse survival.	ursolic acid	144-146	glucose-6-phosphate isomerase 1	Mus musculus	4-7
24143040-0	2013	Determination of oleanolic acid and ursolic acid in Chinese medicinal plants using HPLC with PAH polymeric C18.	ursolic acid	36-48	Bardet-Biedl syndrome 9	Homo sapiens	107-110
25206561-5	2013	As such, ursolic acid has the capacity to significantly increase S100 protein expression levels.	ursolic acid	9-21	S100 calcium binding protein A1	Mus musculus	65-69
25206561-6	2013	Real-time quantitative PCR showed that S100 mRNA expression in the L4-6 segments on the injury side was increased after ursolic acid treatment.	ursolic acid	120-132	S100 calcium binding protein A1	Mus musculus	39-43
25206561-10	2013	Our findings indicate that ursolic acid can dose-dependently increase S100 expression and promote neural regeneration in BALB/c mice following sciatic nerve injury.	ursolic acid	27-39	S100 calcium binding protein A1	Mus musculus	70-74
23900420-0	2013	Ursolic acid stimulates mTORC1 signaling after resistance exercise in rat skeletal muscle.	ursolic acid	0-12	CREB regulated transcription coactivator 1	Mus musculus	24-30
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	26-38	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	26-38	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	26-38	CREB regulated transcription coactivator 1	Mus musculus	191-197
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	26-38	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	40-42	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	40-42	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	40-42	CREB regulated transcription coactivator 1	Mus musculus	191-197
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	40-42	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	143-145	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	143-145	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	143-145	CREB regulated transcription coactivator 1	Mus musculus	191-197
23900420-1	2013	A recent study identified ursolic acid (UA) as a potent stimulator of muscle protein anabolism via PI3K/Akt signaling, thereby suggesting that UA can increase Akt-independent mTOR complex 1 (mTORC1) activation induced by resistance exercise via Akt signaling.	ursolic acid	143-145	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
23900420-2	2013	The purpose of the present study was to investigate the effect of UA on resistance exercise-induced mTORC1 activation.	ursolic acid	66-68	CREB regulated transcription coactivator 1	Mus musculus	100-106
23900420-7	2013	On the other hand, the augmented phosphorylation of p70(S6K) was maintained even 6 h after exercise when UA was injected immediately after exercise.	ursolic acid	105-107	ribosomal protein S6 kinase B1	Rattus norvegicus	56-59
23900420-9	2013	These results indicate that UA is able to sustain resistance exercise-induced mTORC1 activity.	ursolic acid	28-30	CREB regulated transcription coactivator 1	Mus musculus	78-84
23932918-7	2013	Similarly, UA at 2 mg/kg produced significant antinociception in the intracolonic administration of 0.3% capsaicin (a TRPV1 agonist) in mice.	ursolic acid	11-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	118-123
23932918-8	2013	It has been reported the inhibition produced by UA on the calcium-flux induced by capsaicin on TRPV1 receptor suggesting the antagonistic activity of this receptor.	ursolic acid	48-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
23497885-3	2013	Of the non-flavonoid phytochemicals tested, berberine, celastrol, ellagic acid, limonin, oleanolic acid, propyl gallate, sinapic acid and ursolic acid demonstrated significant inhibition of ABCG2-mediated transport.	ursolic acid	138-150	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	190-195
23707761-3	2013	Evidence shows that UA can activate PI3K/Akt signaling and suppress Forkhead box protein O1 (FoxO1) activity.	ursolic acid	20-22	thymoma viral proto-oncogene 1	Mus musculus	41-44
23707761-3	2013	Evidence shows that UA can activate PI3K/Akt signaling and suppress Forkhead box protein O1 (FoxO1) activity.	ursolic acid	20-22	forkhead box O1	Mus musculus	68-91
23707761-3	2013	Evidence shows that UA can activate PI3K/Akt signaling and suppress Forkhead box protein O1 (FoxO1) activity.	ursolic acid	20-22	forkhead box O1	Mus musculus	93-98
23707761-8	2013	Moreover, UA attenuated the mitochondrial dysfunction and cognitive deficits through promoting Akt phosphorylation and FoxO1 nuclear exclusion in the hippocampus of DA-treated mice.	ursolic acid	10-12	thymoma viral proto-oncogene 1	Mus musculus	95-98
23707761-8	2013	Moreover, UA attenuated the mitochondrial dysfunction and cognitive deficits through promoting Akt phosphorylation and FoxO1 nuclear exclusion in the hippocampus of DA-treated mice.	ursolic acid	10-12	forkhead box O1	Mus musculus	119-124
23922935-0	2013	Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway.	ursolic acid	0-12	serine/threonine kinase 11	Homo sapiens	64-68
23922935-6	2013	The results demonstrated that ursolic acid at concentrations ranging from 2.5 microM to 10 microM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein beta (C/EBPbeta), peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT element binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein 1c (SREBP-1c), respectively.	ursolic acid	30-42	CCAAT enhancer binding protein beta	Homo sapiens	221-230
23922935-6	2013	The results demonstrated that ursolic acid at concentrations ranging from 2.5 microM to 10 microM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein beta (C/EBPbeta), peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT element binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein 1c (SREBP-1c), respectively.	ursolic acid	30-42	peroxisome proliferator activated receptor gamma	Homo sapiens	233-281
23922935-6	2013	The results demonstrated that ursolic acid at concentrations ranging from 2.5 microM to 10 microM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein beta (C/EBPbeta), peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT element binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein 1c (SREBP-1c), respectively.	ursolic acid	30-42	peroxisome proliferator activated receptor gamma	Homo sapiens	283-292
23922935-6	2013	The results demonstrated that ursolic acid at concentrations ranging from 2.5 microM to 10 microM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein beta (C/EBPbeta), peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT element binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein 1c (SREBP-1c), respectively.	ursolic acid	30-42	CCAAT enhancer binding protein alpha	Homo sapiens	332-342
23922935-6	2013	The results demonstrated that ursolic acid at concentrations ranging from 2.5 microM to 10 microM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein beta (C/EBPbeta), peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT element binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein 1c (SREBP-1c), respectively.	ursolic acid	30-42	sterol regulatory element binding transcription factor 1	Homo sapiens	348-392
23922935-6	2013	The results demonstrated that ursolic acid at concentrations ranging from 2.5 microM to 10 microM dose-dependently attenuated adipogenesis, accompanied by reduced protein expression of CCAAT element binding protein beta (C/EBPbeta), peroxisome proliferator-activated receptor gamma (PPARgamma), CCAAT element binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein 1c (SREBP-1c), respectively.	ursolic acid	30-42	sterol regulatory element binding transcription factor 1	Homo sapiens	394-402
23922935-7	2013	Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	ursolic acid	0-12	carnitine palmitoyltransferase 1A	Homo sapiens	101-133
23922935-7	2013	Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	ursolic acid	0-12	carnitine palmitoyltransferase 1A	Homo sapiens	135-139
23922935-7	2013	Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	ursolic acid	0-12	fatty acid synthase	Homo sapiens	178-197
23922935-7	2013	Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	ursolic acid	0-12	fatty acid synthase	Homo sapiens	199-202
23922935-7	2013	Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	ursolic acid	0-12	fatty acid binding protein 4	Homo sapiens	208-236
23922935-7	2013	Ursolic acid increased the phosphorylation of acetyl-CoA carboxylase (ACC) and protein expression of carnitine palmitoyltransferase 1 (CPT1), but decreased protein expression of fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4).	ursolic acid	0-12	fatty acid binding protein 4	Homo sapiens	238-243
23922935-8	2013	Ursolic acid increased the phosphorylation of AMP-activated protein kinase (AMPK) and protein expression of (silent mating type information regulation 2, homolog) 1 (Sirt1).	ursolic acid	0-12	sirtuin 1	Homo sapiens	166-171
23922935-11	2013	When LKB1 was silenced with siRNA or the inhibitor radicicol, the effect of UA on AMPK activation was diminished.	ursolic acid	76-78	serine/threonine kinase 11	Homo sapiens	5-9
23922935-12	2013	CONCLUSIONS: Ursolic acid inhibited 3T3-L1 preadipocyte differentiation and adipogenesis through the LKB1/AMPK pathway.	ursolic acid	13-25	serine/threonine kinase 11	Homo sapiens	101-105
24175562-15	2013	CONCLUSION: UA improves the myocardial collagen fibrosis in diabetic mice induced by alloxan, its mechanism may be related to inhibiting the expression of TGF-beta1 and antioxidation.	ursolic acid	12-14	transforming growth factor, beta 1	Mus musculus	155-164
23737956-4	2013	UA also suppressed colon cancer cell migration by inhibiting MMP9 and upregulating CDH1 expression.	ursolic acid	0-2	matrix metallopeptidase 9	Homo sapiens	61-65
23511428-0	2013	Ursolic acid inhibits epithelial-mesenchymal transition by suppressing the expression of astrocyte-elevated gene-1 in human nonsmall cell lung cancer A549 cells.	ursolic acid	0-12	metadherin	Homo sapiens	89-114
23511428-5	2013	In addition, after treatment with UA, the A549 cells showed decreased expression of astrocyte-elevated gene-1 (AEG-1) accompanied by upregulation of E-cadherin and downregulation of N-cadherin and vimentin, which have been reported to characterize the epithelial-mesenchymal transition (EMT).	ursolic acid	34-36	metadherin	Homo sapiens	84-109
23511428-5	2013	In addition, after treatment with UA, the A549 cells showed decreased expression of astrocyte-elevated gene-1 (AEG-1) accompanied by upregulation of E-cadherin and downregulation of N-cadherin and vimentin, which have been reported to characterize the epithelial-mesenchymal transition (EMT).	ursolic acid	34-36	metadherin	Homo sapiens	111-116
23511428-5	2013	In addition, after treatment with UA, the A549 cells showed decreased expression of astrocyte-elevated gene-1 (AEG-1) accompanied by upregulation of E-cadherin and downregulation of N-cadherin and vimentin, which have been reported to characterize the epithelial-mesenchymal transition (EMT).	ursolic acid	34-36	cadherin 1	Homo sapiens	149-159
23511428-5	2013	In addition, after treatment with UA, the A549 cells showed decreased expression of astrocyte-elevated gene-1 (AEG-1) accompanied by upregulation of E-cadherin and downregulation of N-cadherin and vimentin, which have been reported to characterize the epithelial-mesenchymal transition (EMT).	ursolic acid	34-36	cadherin 2	Homo sapiens	182-192
23511428-5	2013	In addition, after treatment with UA, the A549 cells showed decreased expression of astrocyte-elevated gene-1 (AEG-1) accompanied by upregulation of E-cadherin and downregulation of N-cadherin and vimentin, which have been reported to characterize the epithelial-mesenchymal transition (EMT).	ursolic acid	34-36	vimentin	Homo sapiens	197-205
23511428-6	2013	Further results also confirmed that the expression of vimentin was decreased by the siRNA technique to directly knock down AEG-1 expression, indicating that AEG-1 was involved in UA-mediated EMT inhibition.	ursolic acid	179-181	vimentin	Homo sapiens	54-62
23511428-6	2013	Further results also confirmed that the expression of vimentin was decreased by the siRNA technique to directly knock down AEG-1 expression, indicating that AEG-1 was involved in UA-mediated EMT inhibition.	ursolic acid	179-181	metadherin	Homo sapiens	123-128
23511428-6	2013	Further results also confirmed that the expression of vimentin was decreased by the siRNA technique to directly knock down AEG-1 expression, indicating that AEG-1 was involved in UA-mediated EMT inhibition.	ursolic acid	179-181	metadherin	Homo sapiens	157-162
23511428-7	2013	Furthermore, our results showed that UA suppressed the expression level of AEG-1 by repressing nuclear factor-kappaB signaling.	ursolic acid	37-39	metadherin	Homo sapiens	75-80
23511428-8	2013	Altogether, UA inhibited the EMT by suppressing the expression of AEG-1, correlating with inhibition of nuclear factor-kappaB in A549 cells.	ursolic acid	12-14	metadherin	Homo sapiens	66-71
23737956-4	2013	UA also suppressed colon cancer cell migration by inhibiting MMP9 and upregulating CDH1 expression.	ursolic acid	0-2	cadherin 1	Homo sapiens	83-87
23737956-5	2013	Further studies showed that UA inhibited the phosphorylation of Akt and ERK proteins.	ursolic acid	28-30	AKT serine/threonine kinase 1	Homo sapiens	64-67
23737956-5	2013	Further studies showed that UA inhibited the phosphorylation of Akt and ERK proteins.	ursolic acid	28-30	mitogen-activated protein kinase 1	Homo sapiens	72-75
23737956-6	2013	Pretreatment with an Akt or ERK-specific inhibitor considerably abrogated the proliferation inhibition by UA.	ursolic acid	106-108	AKT serine/threonine kinase 1	Homo sapiens	21-24
23737956-6	2013	Pretreatment with an Akt or ERK-specific inhibitor considerably abrogated the proliferation inhibition by UA.	ursolic acid	106-108	mitogen-activated protein kinase 1	Homo sapiens	28-31
23737956-7	2013	UA also significantly inhibited colon cancer cell COX-2 expression and PGE2 production.	ursolic acid	0-2	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
23737956-8	2013	Pretreatment with a COX-2 inhibitor (celecoxib) abrogated the UA-induced cell proliferation.	ursolic acid	62-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
23737956-9	2013	Moreover, we found that UA effectively promoted NF-kappaB and p300 translocation from cell nuclei to cytoplasm, and attenuated the p300-mediated acetylation of NF-kappaB and CREB2.	ursolic acid	24-26	nuclear factor kappa B subunit 1	Homo sapiens	48-57
23737956-9	2013	Moreover, we found that UA effectively promoted NF-kappaB and p300 translocation from cell nuclei to cytoplasm, and attenuated the p300-mediated acetylation of NF-kappaB and CREB2.	ursolic acid	24-26	E1A binding protein p300	Homo sapiens	62-66
23737956-9	2013	Moreover, we found that UA effectively promoted NF-kappaB and p300 translocation from cell nuclei to cytoplasm, and attenuated the p300-mediated acetylation of NF-kappaB and CREB2.	ursolic acid	24-26	E1A binding protein p300	Homo sapiens	131-135
23737956-9	2013	Moreover, we found that UA effectively promoted NF-kappaB and p300 translocation from cell nuclei to cytoplasm, and attenuated the p300-mediated acetylation of NF-kappaB and CREB2.	ursolic acid	24-26	nuclear factor kappa B subunit 1	Homo sapiens	160-169
23737956-9	2013	Moreover, we found that UA effectively promoted NF-kappaB and p300 translocation from cell nuclei to cytoplasm, and attenuated the p300-mediated acetylation of NF-kappaB and CREB2.	ursolic acid	24-26	activating transcription factor 2	Homo sapiens	174-179
23737956-11	2013	Furthermore, UA treatment induced colon cancer cell apoptosis, increased the cleavage of PARP, caspase-3 and 9, and trigged the release of cytochrome c from mitochondrial inter-membrane space into cytosol.	ursolic acid	13-15	collagen type XI alpha 2 chain	Homo sapiens	89-93
23737956-11	2013	Furthermore, UA treatment induced colon cancer cell apoptosis, increased the cleavage of PARP, caspase-3 and 9, and trigged the release of cytochrome c from mitochondrial inter-membrane space into cytosol.	ursolic acid	13-15	caspase 3	Homo sapiens	95-110
23737956-11	2013	Furthermore, UA treatment induced colon cancer cell apoptosis, increased the cleavage of PARP, caspase-3 and 9, and trigged the release of cytochrome c from mitochondrial inter-membrane space into cytosol.	ursolic acid	13-15	cytochrome c, somatic	Homo sapiens	139-151
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	matrix metallopeptidase 9	Homo sapiens	178-182
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	cadherin 1	Homo sapiens	183-187
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	AKT serine/threonine kinase 1	Homo sapiens	189-192
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	mitogen-activated protein kinase 1	Homo sapiens	193-196
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	198-203
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	E1A binding protein p300	Homo sapiens	210-214
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	nuclear factor kappa B subunit 1	Homo sapiens	215-224
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	activating transcription factor 2	Homo sapiens	225-230
23737956-12	2013	These results indicate that UA inhibits cell proliferation and induces apoptosis in colon cancer cells through simultaneous modulation of the multiple signaling pathways such as MMP9/CDH1, Akt/ERK, COX-2/PGE2, p300/NF-kappaB/CREB2, and cytochrome c/caspase pathways.	ursolic acid	28-30	cytochrome c, somatic	Homo sapiens	236-248
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	ursolic acid	48-50	cytochrome c, somatic	Homo sapiens	125-137
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	ursolic acid	48-50	matrix metallopeptidase 9	Homo sapiens	147-151
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	ursolic acid	48-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
23330808-6	2013	Moreover, we found that the enhanced effects of UA and melatonin combination are mediated through simultaneous modulation of cytochrome c/caspase, MMP9/COX-2, and p300/NF-kappaB signaling pathways.	ursolic acid	48-50	E1A binding protein p300	Homo sapiens	163-167
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	cytochrome c, somatic	Homo sapiens	66-78
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	collagen type XI alpha 2 chain	Homo sapiens	172-176
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	matrix metallopeptidase 9	Homo sapiens	210-214
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	219-224
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	E1A binding protein p300	Homo sapiens	246-250
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	E1A binding protein p300	Homo sapiens	346-350
23330808-7	2013	Combined treatment with UA and melatonin triggered the release of cytochrome c from the mitochondrial intermembrane space into the cytosol, induced cleavage of caspase and PARP proteins, enhanced inhibition of MMP9 and COX-2 expression, promoted p300 and NF-kappaB translocation from cell nuclei to cytoplasm, and abrogated NF-kappaB binding and p300 recruitment to COX-2 promoter in colon cancer cells.	ursolic acid	24-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	366-371
23276496-7	2013	Administration of UA also decreased the product of lipid peroxidation, promoted the activation of Nrf2 pathway and decreased the expression of TLR4 and NF-KB after stroke in WT mice.	ursolic acid	18-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	98-102
23584398-0	2013	Ezrin dephosphorylation/downregulation contributes to ursolic acid-mediated cell death in human leukemia cells.	ursolic acid	54-66	ezrin	Homo sapiens	0-5
23584398-3	2013	However, the exact role of ezrin in ursolic acid (UA)-induced apoptosis remains unclear.	ursolic acid	36-48	ezrin	Homo sapiens	27-32
23584398-4	2013	In this study, we show for the first time that UA induces apoptosis in both transformed and primary leukemia cells through dephosphorylation/downregulation of ezrin, association and polarized colocalization of Fas and ezrin, as well as formation of death-inducing signaling complex.	ursolic acid	47-49	ezrin	Homo sapiens	159-164
23584398-4	2013	In this study, we show for the first time that UA induces apoptosis in both transformed and primary leukemia cells through dephosphorylation/downregulation of ezrin, association and polarized colocalization of Fas and ezrin, as well as formation of death-inducing signaling complex.	ursolic acid	47-49	ezrin	Homo sapiens	218-223
23584398-6	2013	Knockdown of ezrin enhanced cell death mediated by UA, whereas overexpression of ezrin attenuated UA-induced apoptosis.	ursolic acid	51-53	ezrin	Homo sapiens	13-18
23247106-0	2013	Ursolic acid sensitizes prostate cancer cells to TRAIL-mediated apoptosis.	ursolic acid	0-12	TNF superfamily member 10	Homo sapiens	49-54
23247106-4	2013	Here, we investigated the sensitizing effects of ursolic acid (UA), a pentacyclic triterpenoid found in many plants, on TRAIL-induced prostate cancer cell apoptosis.	ursolic acid	49-61	TNF superfamily member 10	Homo sapiens	120-125
23247106-4	2013	Here, we investigated the sensitizing effects of ursolic acid (UA), a pentacyclic triterpenoid found in many plants, on TRAIL-induced prostate cancer cell apoptosis.	ursolic acid	63-65	TNF superfamily member 10	Homo sapiens	120-125
23247106-6	2013	This study shows the use of UA as a sensitizer for TRAIL-induced apoptotic cell death offers a promising means of enhancing the efficacy of TRAIL-based prostate cancer treatments.	ursolic acid	28-30	TNF superfamily member 10	Homo sapiens	51-56
23247106-6	2013	This study shows the use of UA as a sensitizer for TRAIL-induced apoptotic cell death offers a promising means of enhancing the efficacy of TRAIL-based prostate cancer treatments.	ursolic acid	28-30	TNF superfamily member 10	Homo sapiens	140-145
23483134-0	2013	Ursolic acid induces apoptosis via Akt/NF-kappaB signaling suppression in T24 human bladder cancer cells.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	35-38
23483134-0	2013	Ursolic acid induces apoptosis via Akt/NF-kappaB signaling suppression in T24 human bladder cancer cells.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	39-48
23483134-2	2013	The present study investigated the role of ursolic acid in the regulation of anti-apoptotic Akt and NF-kappaBp65 signaling.	ursolic acid	43-55	AKT serine/threonine kinase 1	Homo sapiens	92-95
23483134-2	2013	The present study investigated the role of ursolic acid in the regulation of anti-apoptotic Akt and NF-kappaBp65 signaling.	ursolic acid	43-55	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-112
23483134-10	2013	In conclusion, ursolic acid is important in inducing apoptosis via the suppression of Akt/NF-kappaB signaling in T24 human bladder cancer cells and this occurs in a dose-dependent manner.	ursolic acid	15-27	AKT serine/threonine kinase 1	Homo sapiens	86-89
23483134-10	2013	In conclusion, ursolic acid is important in inducing apoptosis via the suppression of Akt/NF-kappaB signaling in T24 human bladder cancer cells and this occurs in a dose-dependent manner.	ursolic acid	15-27	nuclear factor kappa B subunit 1	Homo sapiens	90-99
23584398-6	2013	Knockdown of ezrin enhanced cell death mediated by UA, whereas overexpression of ezrin attenuated UA-induced apoptosis.	ursolic acid	98-100	ezrin	Homo sapiens	81-86
23584398-7	2013	Our in vivo study also showed that UA-mediated inhibition of tumor growth of mouse leukemia xenograft model is in association with the dephosphorylation/downregulation of ezrin.	ursolic acid	35-37	ezrin	Mus musculus	171-176
23584398-8	2013	Such findings suggest that the cytoskeletal protein ezrin may represent an attractive target for UA-mediated lethality in human leukemia cells.	ursolic acid	97-99	ezrin	Homo sapiens	52-57
22841540-0	2013	Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	64-67
22841540-5	2013	Our data show that UA induces apoptosis independent of caspases in HCT15 cells and enhances 5-FU effects associated with an activation of c-jun N-terminal kinase (JNK).	ursolic acid	19-21	mitogen-activated protein kinase 8	Homo sapiens	138-161
22841540-5	2013	Our data show that UA induces apoptosis independent of caspases in HCT15 cells and enhances 5-FU effects associated with an activation of c-jun N-terminal kinase (JNK).	ursolic acid	19-21	mitogen-activated protein kinase 8	Homo sapiens	163-166
22841540-7	2013	UA also modulated autophagy by inducing the accumulation of LC3 and p62 levels with involvement of JNK pathway, which indicates a contribution of autophagy on JNK-dependent induction of cell death by UA.	ursolic acid	0-2	nucleoporin 62	Homo sapiens	68-71
22841540-7	2013	UA also modulated autophagy by inducing the accumulation of LC3 and p62 levels with involvement of JNK pathway, which indicates a contribution of autophagy on JNK-dependent induction of cell death by UA.	ursolic acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	99-102
22841540-7	2013	UA also modulated autophagy by inducing the accumulation of LC3 and p62 levels with involvement of JNK pathway, which indicates a contribution of autophagy on JNK-dependent induction of cell death by UA.	ursolic acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	159-162
22841540-7	2013	UA also modulated autophagy by inducing the accumulation of LC3 and p62 levels with involvement of JNK pathway, which indicates a contribution of autophagy on JNK-dependent induction of cell death by UA.	ursolic acid	200-202	mitogen-activated protein kinase 8	Homo sapiens	159-162
23276496-0	2013	Ursolic acid promotes the neuroprotection by activating Nrf2 pathway after cerebral ischemia in mice.	ursolic acid	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	56-60
23276496-3	2013	In this study, we demonstrated the hypothesis that ursolic acid (UA), a natural pentacyclic triterpenoid acid, isolated from edible plants in the Oleaceae family, a well-known anti-oxidative and anti-inflammatory reagent, protects the brain against ischemic injury by activating the Nrf2 pathway.	ursolic acid	51-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	283-287
23276496-3	2013	In this study, we demonstrated the hypothesis that ursolic acid (UA), a natural pentacyclic triterpenoid acid, isolated from edible plants in the Oleaceae family, a well-known anti-oxidative and anti-inflammatory reagent, protects the brain against ischemic injury by activating the Nrf2 pathway.	ursolic acid	65-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	283-287
23276496-7	2013	Administration of UA also decreased the product of lipid peroxidation, promoted the activation of Nrf2 pathway and decreased the expression of TLR4 and NF-KB after stroke in WT mice.	ursolic acid	18-20	toll-like receptor 4	Mus musculus	143-147
23276496-10	2013	Activation of the Nrf2 pathway contributes to the neuroprotective effects induced by UA in cerebral ischemia.	ursolic acid	85-87	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
23201068-0	2013	Ursolic acid, a potential PPARgamma agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma.	ursolic acid	0-12	peroxisome proliferator activated receptor gamma	Mus musculus	26-35
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	GATA binding protein 3	Mus musculus	202-208
23201068-0	2013	Ursolic acid, a potential PPARgamma agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma.	ursolic acid	0-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	56-65
23201068-0	2013	Ursolic acid, a potential PPARgamma agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma.	ursolic acid	0-12	interleukin 5	Mus musculus	122-126
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	signal transducer and activator of transcription 6	Mus musculus	210-215
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	interleukin 17A	Mus musculus	221-226
23201068-0	2013	Ursolic acid, a potential PPARgamma agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma.	ursolic acid	0-12	interleukin 13	Mus musculus	128-133
23201068-0	2013	Ursolic acid, a potential PPARgamma agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma.	ursolic acid	0-12	interleukin 17A	Mus musculus	139-144
23201068-6	2013	In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways.	ursolic acid	16-28	interleukin 5	Mus musculus	157-161
23201068-6	2013	In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways.	ursolic acid	16-28	interleukin 13	Mus musculus	163-168
23201068-6	2013	In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways.	ursolic acid	16-28	interleukin 17A	Mus musculus	170-175
23201068-6	2013	In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways.	ursolic acid	16-28	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	181-190
23201068-6	2013	In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways.	ursolic acid	16-28	GATA binding protein 3	Mus musculus	220-226
23201068-6	2013	In BALB/c mice, ursolic acid had suppressed eosinophil infiltration, allergic airway inflammation, and Penh, which occurred by suppressing the production of IL-5, IL-13, IL-17, and ovalbumin-specific IgE by blocking the GATA-3 and STAT6 pathways.	ursolic acid	16-28	signal transducer and activator of transcription 6	Mus musculus	231-236
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	heart and neural crest derivatives expressed 2	Mus musculus	95-98
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	interleukin 5	Mus musculus	110-114
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	interleukin 13	Mus musculus	119-124
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	127-136
23201068-7	2013	Our data suggest the therapeutic mechanism of ursolic acid in asthma is based on reductions of Th2 cytokines (IL-5 and IL-13), ovalbumin-specific IgE production, and eosinophil infiltration via the Th2-GATA-3, STAT6, and IL-17-NF-kappaB pathways.	ursolic acid	46-58	heart and neural crest derivatives expressed 2	Mus musculus	198-201
23256797-6	2013	RESULTS: UA markedly rescued lethality, improved survival time and lung pathological changes, inhibited TNF-alpha, IL-6, IL-1beta, HMGB1 and NO, and increased IL-10 expression.	ursolic acid	9-11	tumor necrosis factor	Mus musculus	104-113
26417220-4	2013	We investigated the effect of UA on cytokine production via the MAPK pathways in Jurkat leukemic T-cells, showing that UA inhibited cell growth and proliferation of Jurkat cells, as well as suppressing PMA/PHA induced IL-2 and TNF-alpha production in a concentration and time dependent manner.	ursolic acid	119-121	interleukin 2	Homo sapiens	218-222
26417220-4	2013	We investigated the effect of UA on cytokine production via the MAPK pathways in Jurkat leukemic T-cells, showing that UA inhibited cell growth and proliferation of Jurkat cells, as well as suppressing PMA/PHA induced IL-2 and TNF-alpha production in a concentration and time dependent manner.	ursolic acid	119-121	tumor necrosis factor	Homo sapiens	227-236
26417220-5	2013	The inhibition of IL-2 and TNF-alpha production by UA involved the c-Jun N-terminal kinase (JNK) pathway, but not the extracellular-signal regulated protein kinase (ERK) pathway.	ursolic acid	51-53	interleukin 2	Homo sapiens	18-22
26417220-5	2013	The inhibition of IL-2 and TNF-alpha production by UA involved the c-Jun N-terminal kinase (JNK) pathway, but not the extracellular-signal regulated protein kinase (ERK) pathway.	ursolic acid	51-53	tumor necrosis factor	Homo sapiens	27-36
26417220-5	2013	The inhibition of IL-2 and TNF-alpha production by UA involved the c-Jun N-terminal kinase (JNK) pathway, but not the extracellular-signal regulated protein kinase (ERK) pathway.	ursolic acid	51-53	mitogen-activated protein kinase 8	Homo sapiens	67-90
26417220-5	2013	The inhibition of IL-2 and TNF-alpha production by UA involved the c-Jun N-terminal kinase (JNK) pathway, but not the extracellular-signal regulated protein kinase (ERK) pathway.	ursolic acid	51-53	mitogen-activated protein kinase 8	Homo sapiens	92-95
23182854-0	2013	Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells.	ursolic acid	51-63	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	20-27
23182854-0	2013	Autophagy-dependent EIF2AK3 activation compromises ursolic acid-induced apoptosis through upregulation of MCL1 in MCF-7 human breast cancer cells.	ursolic acid	51-63	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	106-110
23182854-5	2013	Autophagy-dependent ER stress protected the cells from UA-induced apoptosis through EIF2AK3-mediated upregulation of MCL1.	ursolic acid	55-57	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	84-91
23182854-5	2013	Autophagy-dependent ER stress protected the cells from UA-induced apoptosis through EIF2AK3-mediated upregulation of MCL1.	ursolic acid	55-57	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	117-121
23182854-6	2013	Activation of MAPK1/3 but not inhibition of MTOR pathway contributed to UA-induced cytoprotective autophagy in MCF-7 cells.	ursolic acid	72-74	mitogen-activated protein kinase 1	Homo sapiens	14-19
23194884-0	2013	Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2).	ursolic acid	12-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-163
23194884-0	2013	Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2).	ursolic acid	12-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	165-170
23194884-0	2013	Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2).	ursolic acid	26-28	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-163
23194884-0	2013	Delivery of ursolic acid (UA) in polymeric nanoparticles effectively promotes the apoptosis of gastric cancer cells through enhanced inhibition of cyclooxygenase 2 (COX-2).	ursolic acid	26-28	prostaglandin-endoperoxide synthase 2	Homo sapiens	165-170
23194884-1	2013	It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer.	ursolic acid	30-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-148
23194884-1	2013	It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer.	ursolic acid	30-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	150-155
23194884-1	2013	It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer.	ursolic acid	44-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-148
23194884-1	2013	It has been demonstrated that ursolic acid (UA) could effectively induces apoptosis of cancer cells by inhibiting the expression of cyclooxygenase 2 (COX-2), which constitutively expresses in gastric cancer.	ursolic acid	44-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	150-155
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	113-115	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	113-115	caspase 3	Homo sapiens	185-194
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	120-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	120-122	caspase 3	Homo sapiens	185-194
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	120-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	120-122	caspase 3	Homo sapiens	185-194
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	120-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	175-180
23194884-7	2013	The most powerful evidence from this report is that the significant differences between the cytotoxicity of free UA and UA-NPs are closely related to the expression levels of COX-2 and caspase-3, which demonstrates the superiority of UA-NPs over free UA through penetrating cell membrane.	ursolic acid	120-122	caspase 3	Homo sapiens	185-194
23000344-0	2013	Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells.	ursolic acid	0-12	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	52-56
23000344-0	2013	Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	57-60
23000344-3	2013	ER stress inhibitor salubrinal, or PERK silencing, diminishes ursolic acid-induced anti-T24 cell effects.	ursolic acid	62-74	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	35-39
23000344-4	2013	Salubrinal inhibits ursolic acid-induced CHOP expression, Bim ER accumulation and caspase-3 activation in T24 cells.	ursolic acid	20-32	DNA damage inducible transcript 3	Homo sapiens	41-45
23000344-4	2013	Salubrinal inhibits ursolic acid-induced CHOP expression, Bim ER accumulation and caspase-3 activation in T24 cells.	ursolic acid	20-32	caspase 3	Homo sapiens	82-91
23000344-5	2013	Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling.	ursolic acid	0-12	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	21-25
23548129-8	2013	Chemical characterization from HPLC indicated that EA-ACE contains betulinic acid, ursolic acid and oleanolic acid.	ursolic acid	83-95	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	54-57
23000344-5	2013	Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling.	ursolic acid	0-12	TNF receptor associated factor 2	Homo sapiens	26-31
23000344-5	2013	Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling.	ursolic acid	0-12	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	32-36
23000344-5	2013	Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling.	ursolic acid	0-12	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	91-95
23000344-5	2013	Ursolic acid induces IRE1-TRAF2-ASK1 signaling complex formation to activate pro-apoptotic ASK1-JNK signaling.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	96-99
23256797-6	2013	RESULTS: UA markedly rescued lethality, improved survival time and lung pathological changes, inhibited TNF-alpha, IL-6, IL-1beta, HMGB1 and NO, and increased IL-10 expression.	ursolic acid	9-11	interleukin 10	Mus musculus	159-164
23256797-7	2013	In addition, UA can also decrease myeloperoxidase, malondialdehyde, lung wet:dry weight ratio and lung permeability.	ursolic acid	13-15	myeloperoxidase	Mus musculus	34-49
23256797-8	2013	UA attenuated NF-kappaB, HMGB1 and inducible NO synthase protein expression in the lungs.	ursolic acid	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
23256797-8	2013	UA attenuated NF-kappaB, HMGB1 and inducible NO synthase protein expression in the lungs.	ursolic acid	0-2	high mobility group box 1	Mus musculus	25-30
23256797-8	2013	UA attenuated NF-kappaB, HMGB1 and inducible NO synthase protein expression in the lungs.	ursolic acid	0-2	nitric oxide synthase 2, inducible	Mus musculus	35-56
23256797-6	2013	RESULTS: UA markedly rescued lethality, improved survival time and lung pathological changes, inhibited TNF-alpha, IL-6, IL-1beta, HMGB1 and NO, and increased IL-10 expression.	ursolic acid	9-11	interleukin 6	Mus musculus	115-119
23256797-6	2013	RESULTS: UA markedly rescued lethality, improved survival time and lung pathological changes, inhibited TNF-alpha, IL-6, IL-1beta, HMGB1 and NO, and increased IL-10 expression.	ursolic acid	9-11	interleukin 1 beta	Mus musculus	121-129
23256797-6	2013	RESULTS: UA markedly rescued lethality, improved survival time and lung pathological changes, inhibited TNF-alpha, IL-6, IL-1beta, HMGB1 and NO, and increased IL-10 expression.	ursolic acid	9-11	high mobility group box 1	Mus musculus	131-136
24399733-0	2013	Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells.	ursolic acid	50-62	catenin beta 1	Homo sapiens	18-30
24083669-0	2013	Effect of ursolic acid on MAPK in cyclin D1 signaling and RING-type E3 ligase (SCF E3s) in two endometrial cancer cell lines.	ursolic acid	10-22	cyclin D1	Homo sapiens	34-43
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	0-12	cyclin D1	Homo sapiens	87-96
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	0-12	F-box and WD repeat domain containing 8	Homo sapiens	107-112
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	0-12	cullin 1	Homo sapiens	118-125
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	14-16	cyclin D1	Homo sapiens	87-96
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	14-16	F-box and WD repeat domain containing 8	Homo sapiens	107-112
24083669-5	2013	Ursolic acid (UA) treatment of SNG-2 cells, an endometrial cancer cell line, decreased cyclin D1, pERK1/2, FBXW8, and Cullin1 levels in a dose- and time-dependent manner.	ursolic acid	14-16	cullin 1	Homo sapiens	118-125
24083669-7	2013	In SNG-2, both dose- and time-dependent inhibition of Rbx 1 were observed following treatment with UA.	ursolic acid	99-101	ring-box 1	Homo sapiens	54-59
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	glycogen synthase kinase 3 beta	Homo sapiens	17-25
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	Wnt family member 3A	Homo sapiens	48-53
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	Wnt family member 3A	Homo sapiens	74-79
24399733-0	2013	Inhibition of Wnt/beta-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells.	ursolic acid	50-62	actin related protein 1B	Homo sapiens	84-88
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	caspase 3	Homo sapiens	110-119
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	poly(ADP-ribose) polymerase 1	Homo sapiens	124-128
24399733-9	2013	Furthermore, the GSK3beta inhibitor SB216763 or Wnt3a-conditioned medium (Wnt3a-CM) reversed the cleavages of caspase-3 and PARP induced by ursolic acid in PC-3 cells.	ursolic acid	140-152	actin related protein 1B	Homo sapiens	156-160
24399733-3	2013	To investigate the antitumor mechanism, the apoptotic mechanism of ursolic acid via Wnt/beta-catenin signaling was examined in PC-3 prostate cancer cells.	ursolic acid	67-79	catenin beta 1	Homo sapiens	88-100
24399733-10	2013	CONCLUSIONS: Our findings suggest that ursolic acid induces apoptosis via inhibition of the Wnt5/beta-catenin pathway and activation of caspase in PC-3 prostate cancer cells.	ursolic acid	39-51	catenin beta 1	Homo sapiens	97-109
24399733-3	2013	To investigate the antitumor mechanism, the apoptotic mechanism of ursolic acid via Wnt/beta-catenin signaling was examined in PC-3 prostate cancer cells.	ursolic acid	67-79	actin related protein 1B	Homo sapiens	127-131
24399733-10	2013	CONCLUSIONS: Our findings suggest that ursolic acid induces apoptosis via inhibition of the Wnt5/beta-catenin pathway and activation of caspase in PC-3 prostate cancer cells.	ursolic acid	39-51	caspase 9	Homo sapiens	136-143
24399733-5	2013	RESULTS: Ursolic acid showed cytotoxicity against PC-3, LNCaP and DU145 prostate cancer cells with IC50 of 35 muM, 47 muM and 80 muM, respectively.	ursolic acid	9-21	actin related protein 1B	Homo sapiens	50-54
24399733-10	2013	CONCLUSIONS: Our findings suggest that ursolic acid induces apoptosis via inhibition of the Wnt5/beta-catenin pathway and activation of caspase in PC-3 prostate cancer cells.	ursolic acid	39-51	actin related protein 1B	Homo sapiens	147-151
24399733-5	2013	RESULTS: Ursolic acid showed cytotoxicity against PC-3, LNCaP and DU145 prostate cancer cells with IC50 of 35 muM, 47 muM and 80 muM, respectively.	ursolic acid	9-21	latexin	Homo sapiens	110-113
24399733-5	2013	RESULTS: Ursolic acid showed cytotoxicity against PC-3, LNCaP and DU145 prostate cancer cells with IC50 of 35 muM, 47 muM and 80 muM, respectively.	ursolic acid	9-21	latexin	Homo sapiens	118-121
24399733-5	2013	RESULTS: Ursolic acid showed cytotoxicity against PC-3, LNCaP and DU145 prostate cancer cells with IC50 of 35 muM, 47 muM and 80 muM, respectively.	ursolic acid	9-21	latexin	Homo sapiens	118-121
24399733-6	2013	Also, ursolic acid significantly increased the number of ethidium homodimer stained cells and apoptotic bodies, and dose-dependently enhanced the sub-G1 apoptotic accumulation in PC-3 cells.	ursolic acid	6-18	actin related protein 1B	Homo sapiens	179-183
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	poly(ADP-ribose) polymerase 1	Homo sapiens	108-112
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	caspase 9	Homo sapiens	125-141
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	BCL2 like 1	Homo sapiens	198-204
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	BCL2 apoptosis regulator	Homo sapiens	206-211
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	216-221
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	BCL2 associated X, apoptosis regulator	Homo sapiens	257-260
24399733-7	2013	Consistently, western blotting revealed that ursolic acid effectively cleaved poly (ADP-ribose) polymerase (PARP), activated caspase-9 and -3, suppressed the expression of survival proteins such as Bcl-XL, Bcl-2 and Mcl-1, and upregulated the expression of Bax in PC-3 cells.	ursolic acid	45-57	actin related protein 1B	Homo sapiens	264-268
24399733-8	2013	Interestingly, ursolic acid suppressed the expression of Wnt5alpha/beta and beta-catenin, and enhanced the phosphorylation of glycogen synthase kinase 3 beta (GSK3beta).	ursolic acid	15-27	catenin beta 1	Homo sapiens	76-88
24399733-8	2013	Interestingly, ursolic acid suppressed the expression of Wnt5alpha/beta and beta-catenin, and enhanced the phosphorylation of glycogen synthase kinase 3 beta (GSK3beta).	ursolic acid	15-27	glycogen synthase kinase 3 beta	Homo sapiens	126-157
24399733-8	2013	Interestingly, ursolic acid suppressed the expression of Wnt5alpha/beta and beta-catenin, and enhanced the phosphorylation of glycogen synthase kinase 3 beta (GSK3beta).	ursolic acid	15-27	glycogen synthase kinase 3 beta	Homo sapiens	159-167
22832932-3	2012	EXPERIMENTAL DESIGN: The effect of ursolic acid on proliferation of CRC cell lines was examined by mitochondrial dye uptake assay, apoptosis by esterase staining, NF-kappaB activation by DNA-binding assay, and protein expression by Western blot.	ursolic acid	35-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	163-172
22551965-6	2012	In in vitro condition, it could be shown that UA inhibits VCAM-1 expression downstream of NFkappaB and is likely to interfere with VCAM-1 protein synthesis in endothelial cells.	ursolic acid	46-48	vascular cell adhesion molecule 1	Rattus norvegicus	58-64
22551965-6	2012	In in vitro condition, it could be shown that UA inhibits VCAM-1 expression downstream of NFkappaB and is likely to interfere with VCAM-1 protein synthesis in endothelial cells.	ursolic acid	46-48	vascular cell adhesion molecule 1	Rattus norvegicus	131-137
22551965-8	2012	CONCLUSIONS: Our results suggest that UA-mediated inhibition of endothelial VCAM-1 expression reduces the infiltration of venous bypass grafts by CD45-positive cells and inhibits intimal hyperplasia.	ursolic acid	38-40	vascular cell adhesion molecule 1	Rattus norvegicus	76-82
22959527-0	2012	Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.	ursolic acid	19-31	tumor protein p53	Homo sapiens	119-122
22959527-0	2012	Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21waf1 and NOXA in pancreatic cancer cells.	ursolic acid	19-31	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	136-140
22407769-5	2012	By activity guided purification, three compounds of BACE1 inhibitors p-coumaric acid, gallic acid and ursolic acid were isolated from Corni fructus EtOAc fraction.	ursolic acid	102-114	beta-secretase 1	Homo sapiens	52-57
22832932-8	2012	Immunohistochemistry of tumor tissue indicated that ursolic acid downregulated biomarkers of proliferation (Ki-67) and microvessel density (CD31).	ursolic acid	52-64	platelet/endothelial cell adhesion molecule 1	Mus musculus	140-144
22832932-10	2012	In addition, ursolic acid suppressed EGF receptor (EGFR) and induced p53 and p21 expression.	ursolic acid	13-25	transformation related protein 53, pseudogene	Mus musculus	69-72
22832932-10	2012	In addition, ursolic acid suppressed EGF receptor (EGFR) and induced p53 and p21 expression.	ursolic acid	13-25	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	77-80
22964500-5	2012	However, UA, p-CA, and GA not only suppressed the generation of ROS but also attenuated DNA fragmentation and eventually attenuated Abeta-induced apoptosis in a dose-dependent manner.	ursolic acid	9-11	amyloid beta precursor protein	Rattus norvegicus	132-137
22353043-0	2012	Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	111-120
22858837-4	2012	UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway.	ursolic acid	0-2	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	13-16
22858837-4	2012	UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway.	ursolic acid	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
22858837-4	2012	UA mitigated CSE-induced DNA damage through the Nrf2 (nuclear factor erythroid 2-related factor 2) pathway.	ursolic acid	0-2	NFE2 like bZIP transcription factor 2	Homo sapiens	54-97
22353043-0	2012	Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	0-12	microRNA 21	Homo sapiens	121-127
22353043-0	2012	Ursolic acid inhibits proliferation and induces apoptosis in human glioblastoma cell lines U251 by suppressing TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	0-12	programmed cell death 4	Homo sapiens	128-133
22353043-6	2012	UA increased the activation of caspase-3 and markedly suppressed levels of microRNA-21 (miR-21) in a time-dependent manner.	ursolic acid	0-2	caspase 3	Homo sapiens	31-40
22353043-6	2012	UA increased the activation of caspase-3 and markedly suppressed levels of microRNA-21 (miR-21) in a time-dependent manner.	ursolic acid	0-2	microRNA 21	Homo sapiens	75-86
22353043-6	2012	UA increased the activation of caspase-3 and markedly suppressed levels of microRNA-21 (miR-21) in a time-dependent manner.	ursolic acid	0-2	microRNA 21	Homo sapiens	88-94
22353043-8	2012	And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA.	ursolic acid	90-92	microRNA 21	Homo sapiens	23-29
22353043-8	2012	And over-expression of miR-21 in U251 cells abolished the enhancement of PDCD4 protein by UA.	ursolic acid	90-92	programmed cell death 4	Homo sapiens	73-78
22353043-10	2012	These findings suggest that UA inhibits cell growth via causing apoptosis in U251 cells by a UA-triggered TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	28-30	transforming growth factor beta 1	Homo sapiens	106-115
22353043-10	2012	These findings suggest that UA inhibits cell growth via causing apoptosis in U251 cells by a UA-triggered TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	28-30	microRNA 21	Homo sapiens	116-122
22521508-0	2012	The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells.	ursolic acid	64-76	purinergic receptor P2Y2	Homo sapiens	4-8
22353043-10	2012	These findings suggest that UA inhibits cell growth via causing apoptosis in U251 cells by a UA-triggered TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	28-30	programmed cell death 4	Homo sapiens	123-128
22521508-0	2012	The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells.	ursolic acid	64-76	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	9-12
22521508-0	2012	The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells.	ursolic acid	64-76	mitogen-activated protein kinase 14	Homo sapiens	13-16
22521508-0	2012	The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells.	ursolic acid	64-76	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-22
22521508-3	2012	Previously, we showed that HT-29 colorectal cancer cells undergoing apoptosis overexpressed cyclooxygenase-2 (COX-2), in a p38 dependent pathway, to delay ursolic acid-induced apoptosis.	ursolic acid	155-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-108
22521508-3	2012	Previously, we showed that HT-29 colorectal cancer cells undergoing apoptosis overexpressed cyclooxygenase-2 (COX-2), in a p38 dependent pathway, to delay ursolic acid-induced apoptosis.	ursolic acid	155-167	prostaglandin-endoperoxide synthase 2	Homo sapiens	110-115
22521508-3	2012	Previously, we showed that HT-29 colorectal cancer cells undergoing apoptosis overexpressed cyclooxygenase-2 (COX-2), in a p38 dependent pathway, to delay ursolic acid-induced apoptosis.	ursolic acid	155-167	mitogen-activated protein kinase 14	Homo sapiens	123-126
22353043-10	2012	These findings suggest that UA inhibits cell growth via causing apoptosis in U251 cells by a UA-triggered TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	93-95	transforming growth factor beta 1	Homo sapiens	106-115
22353043-10	2012	These findings suggest that UA inhibits cell growth via causing apoptosis in U251 cells by a UA-triggered TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	93-95	microRNA 21	Homo sapiens	116-122
22353043-10	2012	These findings suggest that UA inhibits cell growth via causing apoptosis in U251 cells by a UA-triggered TGF-beta1/miR-21/PDCD4 pathway.	ursolic acid	93-95	programmed cell death 4	Homo sapiens	123-128
22883405-0	2012	[Effects of ursolic acid on c-Cbl-associated protein expression in 3T3-L1 adipocytes with insulin resistance].	ursolic acid	12-24	sorbin and SH3 domain containing 1	Mus musculus	28-52
22641480-0	2012	Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant             human pancreatic cancer via the JNK and PI3K/Akt/NF-kappaB pathways.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	120-123
22641480-0	2012	Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant             human pancreatic cancer via the JNK and PI3K/Akt/NF-kappaB pathways.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	133-136
22641480-0	2012	Ursolic acid inhibits growth and induces apoptosis in gemcitabine-resistant             human pancreatic cancer via the JNK and PI3K/Akt/NF-kappaB pathways.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	137-146
22641480-9	2012	The JNK inhibitor             SP600125 partly abrogated the caspase-9 activation caused by UA.	ursolic acid	91-93	mitogen-activated protein kinase 8	Homo sapiens	4-7
22641480-9	2012	The JNK inhibitor             SP600125 partly abrogated the caspase-9 activation caused by UA.	ursolic acid	91-93	caspase 9	Homo sapiens	60-69
22883405-11	2012	Effects of UA on the expressions of aP2 and MMP-1 were not obvious, but UA could up-regulate expression of CAP both in mRNA and protein levels (P&lt;0.01).	ursolic acid	11-13	fatty acid binding protein 4, adipocyte	Mus musculus	36-39
22883405-12	2012	CONCLUSION: Low- and high-dose UA can improve the glycometabolism and differentiation of 3T3-L1 adipocytes with insulin resistance by up-regulating the expression of CAP.	ursolic acid	31-33	sorbin and SH3 domain containing 1	Mus musculus	166-169
22883405-6	2012	Finally, real-time fluorescence quantitative polymerase chain reaction and Western blot methods were used to detect the effects of UA on expressions of adipocyte lipid binding protein (aP2), c-Cbl-associated protein (CAP) and matrix metalloproteinase-1 (MMP-1) in 3T3-L1 cells with insulin resistance.	ursolic acid	131-133	fatty acid binding protein 4, adipocyte	Mus musculus	152-183
22883405-6	2012	Finally, real-time fluorescence quantitative polymerase chain reaction and Western blot methods were used to detect the effects of UA on expressions of adipocyte lipid binding protein (aP2), c-Cbl-associated protein (CAP) and matrix metalloproteinase-1 (MMP-1) in 3T3-L1 cells with insulin resistance.	ursolic acid	131-133	fatty acid binding protein 4, adipocyte	Mus musculus	185-188
22805086-6	2012	CONCLUSION: The effects of ursolic acid in improving hepatic insulin resistance in KKAy mice with spontaneous type 2 diabetes may be closely related to affecting the contents of FFA, TNF-alpha and adiponectin, improving the expression of PPARalpha protein, regulating transcription of PEPCK protein and inducing phosphorylation of IRS-2.	ursolic acid	27-39	tumor necrosis factor	Mus musculus	183-192
22805086-6	2012	CONCLUSION: The effects of ursolic acid in improving hepatic insulin resistance in KKAy mice with spontaneous type 2 diabetes may be closely related to affecting the contents of FFA, TNF-alpha and adiponectin, improving the expression of PPARalpha protein, regulating transcription of PEPCK protein and inducing phosphorylation of IRS-2.	ursolic acid	27-39	adiponectin, C1Q and collagen domain containing	Mus musculus	197-208
22805086-6	2012	CONCLUSION: The effects of ursolic acid in improving hepatic insulin resistance in KKAy mice with spontaneous type 2 diabetes may be closely related to affecting the contents of FFA, TNF-alpha and adiponectin, improving the expression of PPARalpha protein, regulating transcription of PEPCK protein and inducing phosphorylation of IRS-2.	ursolic acid	27-39	peroxisome proliferator activated receptor alpha	Mus musculus	238-247
22805086-6	2012	CONCLUSION: The effects of ursolic acid in improving hepatic insulin resistance in KKAy mice with spontaneous type 2 diabetes may be closely related to affecting the contents of FFA, TNF-alpha and adiponectin, improving the expression of PPARalpha protein, regulating transcription of PEPCK protein and inducing phosphorylation of IRS-2.	ursolic acid	27-39	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	285-290
22805086-6	2012	CONCLUSION: The effects of ursolic acid in improving hepatic insulin resistance in KKAy mice with spontaneous type 2 diabetes may be closely related to affecting the contents of FFA, TNF-alpha and adiponectin, improving the expression of PPARalpha protein, regulating transcription of PEPCK protein and inducing phosphorylation of IRS-2.	ursolic acid	27-39	insulin receptor substrate 2	Mus musculus	331-336
22644855-0	2012	Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFkappaB pathway in streptozocin-induced diabetic rats.	ursolic acid	32-44	advanced glycosylation end product-specific receptor	Rattus norvegicus	53-57
22644855-10	2012	Oxidative balance was also normalized in the UA-treated rats, and a marked reduction in the levels of RAGE and p22phox paralleled the reduced activation of NF-kappaB p65 and TNF-alpha (p &lt; 0.01 and p &lt; 0.05, respectively, vs diabetic model).	ursolic acid	45-47	advanced glycosylation end product-specific receptor	Rattus norvegicus	102-106
22644855-10	2012	Oxidative balance was also normalized in the UA-treated rats, and a marked reduction in the levels of RAGE and p22phox paralleled the reduced activation of NF-kappaB p65 and TNF-alpha (p &lt; 0.01 and p &lt; 0.05, respectively, vs diabetic model).	ursolic acid	45-47	cytochrome b-245 alpha chain	Rattus norvegicus	111-118
22644855-10	2012	Oxidative balance was also normalized in the UA-treated rats, and a marked reduction in the levels of RAGE and p22phox paralleled the reduced activation of NF-kappaB p65 and TNF-alpha (p &lt; 0.01 and p &lt; 0.05, respectively, vs diabetic model).	ursolic acid	45-47	synaptotagmin 1	Rattus norvegicus	166-169
22289617-9	2012	UA influenced decreased DNA fragmentation and an apoptosis by upregulation of anti-apoptotic proteins such as Bcl-2, Bcl-xL and down-regulation of Bax, caspase-3, -8 and -9, cytochrome c, TNF-alpha, Fas through mitochondrial pathway.	ursolic acid	0-2	BCL2, apoptosis regulator	Rattus norvegicus	110-115
22289617-9	2012	UA influenced decreased DNA fragmentation and an apoptosis by upregulation of anti-apoptotic proteins such as Bcl-2, Bcl-xL and down-regulation of Bax, caspase-3, -8 and -9, cytochrome c, TNF-alpha, Fas through mitochondrial pathway.	ursolic acid	0-2	Bcl2-like 1	Rattus norvegicus	117-123
22289617-9	2012	UA influenced decreased DNA fragmentation and an apoptosis by upregulation of anti-apoptotic proteins such as Bcl-2, Bcl-xL and down-regulation of Bax, caspase-3, -8 and -9, cytochrome c, TNF-alpha, Fas through mitochondrial pathway.	ursolic acid	0-2	BCL2 associated X, apoptosis regulator	Rattus norvegicus	147-150
22289617-9	2012	UA influenced decreased DNA fragmentation and an apoptosis by upregulation of anti-apoptotic proteins such as Bcl-2, Bcl-xL and down-regulation of Bax, caspase-3, -8 and -9, cytochrome c, TNF-alpha, Fas through mitochondrial pathway.	ursolic acid	0-2	caspase 3	Rattus norvegicus	152-172
22289617-9	2012	UA influenced decreased DNA fragmentation and an apoptosis by upregulation of anti-apoptotic proteins such as Bcl-2, Bcl-xL and down-regulation of Bax, caspase-3, -8 and -9, cytochrome c, TNF-alpha, Fas through mitochondrial pathway.	ursolic acid	0-2	tumor necrosis factor	Rattus norvegicus	188-197
22644855-10	2012	Oxidative balance was also normalized in the UA-treated rats, and a marked reduction in the levels of RAGE and p22phox paralleled the reduced activation of NF-kappaB p65 and TNF-alpha (p &lt; 0.01 and p &lt; 0.05, respectively, vs diabetic model).	ursolic acid	45-47	tumor necrosis factor	Rattus norvegicus	174-183
22644855-11	2012	These findings suggest that UA may suppress oxidative stress, thus blunting activation of the RAGE-NADPH oxidase-NF-kappaB signal transduction pathway, to ameliorate vascular injury in the STZ-induced DM rats.	ursolic acid	28-30	advanced glycosylation end product-specific receptor	Rattus norvegicus	94-98
22387548-6	2012	Further, activation of AMPK by UA promoted c-Jun N-terminal kinase (JNK) activation, but inhibited mTOR complex 1 (mTORC1) signaling to cause survivin down-regulation.	ursolic acid	31-33	mitogen-activated protein kinase 8	Homo sapiens	43-66
22136205-8	2012	In addition, ursolic acid treatment significantly increased cyclin D1, cyclin E and C/EBPbeta protein expression levels at 36 h after liver PHx compared with the vehicle-treated control mice.	ursolic acid	13-25	cyclin D1	Mus musculus	60-69
22136205-8	2012	In addition, ursolic acid treatment significantly increased cyclin D1, cyclin E and C/EBPbeta protein expression levels at 36 h after liver PHx compared with the vehicle-treated control mice.	ursolic acid	13-25	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	84-93
22136205-9	2012	DISCUSSION AND CONCLUSION: All these results suggest that ursolic acid stimulates liver proliferation after partial hepatectomy, and this effect may be associated with the stimulation of C/EBPbeta expression.	ursolic acid	58-70	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	187-196
22387548-6	2012	Further, activation of AMPK by UA promoted c-Jun N-terminal kinase (JNK) activation, but inhibited mTOR complex 1 (mTORC1) signaling to cause survivin down-regulation.	ursolic acid	31-33	mitogen-activated protein kinase 8	Homo sapiens	68-71
22387548-6	2012	Further, activation of AMPK by UA promoted c-Jun N-terminal kinase (JNK) activation, but inhibited mTOR complex 1 (mTORC1) signaling to cause survivin down-regulation.	ursolic acid	31-33	CREB regulated transcription coactivator 1	Mus musculus	115-121
21950524-2	2012	In the present study, we investigated the ability of UA to induce apoptosis in human leukaemia cells in relation to its effects on caspase activation, Mcl-1 down-regulation and perturbations in stress-induced signalling pathways such as PKB and JNK.	ursolic acid	53-55	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	151-156
22477202-0	2012	Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	121-124
22477202-4	2012	Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases.	ursolic acid	27-29	phosphatase and tensin homolog	Homo sapiens	158-162
22477202-4	2012	Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases.	ursolic acid	27-29	AKT serine/threonine kinase 1	Homo sapiens	188-191
22477202-4	2012	Here, we demonstrated that UA was able to inhibit growth, induce apoptosis in a human chronic myelogenous leukemia cell line (K562 cells) via upregulation of PTEN gene expression, inhibit Akt kinase activity, change mitochondrial transmembrane potential and reduce the release of cytochrome c and the activity of caspases.	ursolic acid	27-29	cytochrome c, somatic	Homo sapiens	280-292
22477202-5	2012	These results suggest that UA may elicit its strong antitumor effects via upregulation of the PTEN gene and inhibition of the PI3K/Akt pathway.	ursolic acid	27-29	phosphatase and tensin homolog	Homo sapiens	94-98
22477202-5	2012	These results suggest that UA may elicit its strong antitumor effects via upregulation of the PTEN gene and inhibition of the PI3K/Akt pathway.	ursolic acid	27-29	AKT serine/threonine kinase 1	Homo sapiens	131-134
24116298-10	2012	Ursolic acid exhibited significant inhibition of DBH (214 mumol/L), weak inhibition of MAO-B (780 mumol/L), and no inhibition against MAO-A.	ursolic acid	0-12	monoamine oxidase B	Rattus norvegicus	87-92
22477202-0	2012	Ursolic acid-induced apoptosis in K562 cells involving upregulation of PTEN gene expression and inactivation of the PI3K/Akt pathway.	ursolic acid	0-12	phosphatase and tensin homolog	Homo sapiens	71-75
21950524-2	2012	In the present study, we investigated the ability of UA to induce apoptosis in human leukaemia cells in relation to its effects on caspase activation, Mcl-1 down-regulation and perturbations in stress-induced signalling pathways such as PKB and JNK.	ursolic acid	53-55	mitogen-activated protein kinase 8	Homo sapiens	245-248
21950524-5	2012	KEY RESULTS: UA induced apoptosis in human leukaemia cells in a dose- and time-dependent manner; this was associated with caspase activation, down-regulation of Mcl-1 and inactivation of PKB accompanied by activation of JNK.	ursolic acid	13-15	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	161-166
21950524-5	2012	KEY RESULTS: UA induced apoptosis in human leukaemia cells in a dose- and time-dependent manner; this was associated with caspase activation, down-regulation of Mcl-1 and inactivation of PKB accompanied by activation of JNK.	ursolic acid	13-15	mitogen-activated protein kinase 8	Homo sapiens	220-223
21950524-6	2012	Enforced activation of PKB by a constitutively active PKB construct prevented UA-mediated JNK activation, Mcl-1 down-regulation, caspase activation and apoptosis.	ursolic acid	78-80	mitogen-activated protein kinase 8	Homo sapiens	90-93
21950524-6	2012	Enforced activation of PKB by a constitutively active PKB construct prevented UA-mediated JNK activation, Mcl-1 down-regulation, caspase activation and apoptosis.	ursolic acid	78-80	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	106-111
21950524-8	2012	Interruption of the JNK pathway by pharmacological or genetic (e.g. siRNA) attenuated UA-induced apoptosis.	ursolic acid	86-88	mitogen-activated protein kinase 8	Homo sapiens	20-23
21950524-9	2012	Furthermore, UA-mediated inhibition of tumour growth in vivo was associated with induction of apoptosis, inactivation of PKB as well as activation of JNK.	ursolic acid	13-15	mitogen-activated protein kinase 8	Homo sapiens	150-153
21950524-10	2012	CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis.	ursolic acid	91-93	mitogen-activated protein kinase 8	Homo sapiens	186-189
21950524-10	2012	CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis.	ursolic acid	91-93	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	220-225
21950524-10	2012	CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis.	ursolic acid	146-148	mitogen-activated protein kinase 8	Homo sapiens	186-189
21950524-10	2012	CONCLUSIONS AND IMPLICATIONS: Collectively, these findings suggest a hierarchical model of UA-induced apoptosis in human leukaemia cells in which UA induces PKB inactivation, leading to JNK activation and culminating in Mcl-1 down-regulation, caspase activation and apoptosis.	ursolic acid	146-148	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	220-225
22239065-6	2012	IR-induced apoptosis in cancer cell lines such as DU145, CT26 and B16F10 was significantly enhanced by UA, as reflected by DNA fragmentation, cellular redox status, mitochondrial dysfunction and modulation of apoptotic marker proteins.	ursolic acid	103-105	DEAD-box helicase 53	Homo sapiens	57-61
22178132-8	2012	Inhibition of autophagy by either 3-methyladenine or Beclin-1/Atg5 small interfering RNA enhanced UA-induced apoptosis.	ursolic acid	98-100	autophagy related 5	Homo sapiens	62-66
21191671-0	2012	Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells.	ursolic acid	0-12	forkhead box M1	Homo sapiens	64-69
21191671-4	2012	After treatment, UA-induced apoptosis was accompanied by a significant decrease in CyclinD1/CDK4 expression, which can be regulated by FoxM1.	ursolic acid	17-19	cyclin D1	Homo sapiens	83-91
21191671-4	2012	After treatment, UA-induced apoptosis was accompanied by a significant decrease in CyclinD1/CDK4 expression, which can be regulated by FoxM1.	ursolic acid	17-19	cyclin dependent kinase 4	Homo sapiens	92-96
21191671-4	2012	After treatment, UA-induced apoptosis was accompanied by a significant decrease in CyclinD1/CDK4 expression, which can be regulated by FoxM1.	ursolic acid	17-19	forkhead box M1	Homo sapiens	135-140
21191671-6	2012	The result of Western blot suggested that ursolic acid inhibited the expression of FoxM1.	ursolic acid	42-54	forkhead box M1	Homo sapiens	83-88
21191671-7	2012	Taken together, the data suggest that the proapoptotic effect of UA on MCF-7 cells is mediated by inhibition of FoxM1 and is highly correlated with inactivation of CyclinD1/CDK4.	ursolic acid	65-67	forkhead box M1	Homo sapiens	112-117
21191671-7	2012	Taken together, the data suggest that the proapoptotic effect of UA on MCF-7 cells is mediated by inhibition of FoxM1 and is highly correlated with inactivation of CyclinD1/CDK4.	ursolic acid	65-67	cyclin D1	Homo sapiens	164-172
21191671-7	2012	Taken together, the data suggest that the proapoptotic effect of UA on MCF-7 cells is mediated by inhibition of FoxM1 and is highly correlated with inactivation of CyclinD1/CDK4.	ursolic acid	65-67	cyclin dependent kinase 4	Homo sapiens	173-177
22178132-0	2012	Autophagy inhibition enhances ursolic acid-induced apoptosis in PC3 cells.	ursolic acid	30-42	proprotein convertase subtilisin/kexin type 1	Homo sapiens	64-67
22178132-5	2012	UA-induced autophagy in PC3 cells is associated with the reduced cell viability and the enhanced expression of LC3-II, an autophagosome marker in mammals, and monodansylcadaverine incorporation into autolysosomes.	ursolic acid	0-2	proprotein convertase subtilisin/kexin type 1	Homo sapiens	24-27
22178132-9	2012	Taken together, our data suggest that autophagy functions as a survival mechanism in PC3 cells against UA-induced apoptosis and a rational for the use of autophagy inhibitors in combination with UA as a novel modality of cancer therapy.	ursolic acid	103-105	proprotein convertase subtilisin/kexin type 1	Homo sapiens	85-88
22178132-7	2012	We also show that UA-induced autophagy in PC3 cells are mediated through the Beclin-1 and Akt/mTOR pathways.	ursolic acid	18-20	proprotein convertase subtilisin/kexin type 1	Homo sapiens	42-45
22178132-7	2012	We also show that UA-induced autophagy in PC3 cells are mediated through the Beclin-1 and Akt/mTOR pathways.	ursolic acid	18-20	beclin 1	Homo sapiens	77-85
22108347-8	2012	UA can inhibit CRP-induced proliferation of HUVECs.	ursolic acid	0-2	C-reactive protein	Homo sapiens	15-18
22178132-7	2012	We also show that UA-induced autophagy in PC3 cells are mediated through the Beclin-1 and Akt/mTOR pathways.	ursolic acid	18-20	AKT serine/threonine kinase 1	Homo sapiens	90-93
22178132-7	2012	We also show that UA-induced autophagy in PC3 cells are mediated through the Beclin-1 and Akt/mTOR pathways.	ursolic acid	18-20	mechanistic target of rapamycin kinase	Homo sapiens	94-98
22178132-8	2012	Inhibition of autophagy by either 3-methyladenine or Beclin-1/Atg5 small interfering RNA enhanced UA-induced apoptosis.	ursolic acid	98-100	beclin 1	Homo sapiens	53-61
22108347-0	2012	Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP.	ursolic acid	0-12	interleukin 6	Homo sapiens	24-28
22108347-0	2012	Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP.	ursolic acid	0-12	C-reactive protein	Homo sapiens	37-55
22108347-0	2012	Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP.	ursolic acid	0-12	C-reactive protein	Homo sapiens	119-122
22154965-12	2012	In addition, carnosol and ursolic acid/oleanolic acid contained in this plant appears to contribute for the antinociceptive property of the extract, possibly through a modulatory influence on TRPA1-receptors.	ursolic acid	26-38	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	192-197
22108347-9	2012	CRP can obviously increase LOX-1/VCAM-1 expression in HUVECs, both on mRNA and protein levels and the effect of CRP can be inhibited by UA (5, 10, 20 mumol/L) in a dose-dependent manner.	ursolic acid	136-138	C-reactive protein	Homo sapiens	0-3
22108347-1	2012	OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs).	ursolic acid	52-64	C-reactive protein	Homo sapiens	91-109
22108347-9	2012	CRP can obviously increase LOX-1/VCAM-1 expression in HUVECs, both on mRNA and protein levels and the effect of CRP can be inhibited by UA (5, 10, 20 mumol/L) in a dose-dependent manner.	ursolic acid	136-138	oxidized low density lipoprotein receptor 1	Homo sapiens	27-32
22108347-1	2012	OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs).	ursolic acid	52-64	C-reactive protein	Homo sapiens	111-114
22108347-1	2012	OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs).	ursolic acid	52-64	interleukin 6	Homo sapiens	127-131
22108347-1	2012	OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs).	ursolic acid	66-68	C-reactive protein	Homo sapiens	91-109
22108347-1	2012	OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs).	ursolic acid	66-68	C-reactive protein	Homo sapiens	111-114
22108347-1	2012	OBJECTIVE: To investigate the inhibitory effects of ursolic acid (UA) on the expression of C-reactive protein (CRP) induced by IL-6 in HepG2 cells and the protective effects on the CRP-induced injury to human umbilical vein endothelial cells (HUVECs).	ursolic acid	66-68	interleukin 6	Homo sapiens	127-131
22108347-7	2012	RESULT: IL-6 can significantly increase CRP protein and mRNA expression in HepG2 cells, and this effect of IL-6 can be decreased by UA (6.25, 12.5, 25 mumol/L) markedly in a dose-dependent manner.	ursolic acid	132-134	C-reactive protein	Homo sapiens	40-43
22108347-7	2012	RESULT: IL-6 can significantly increase CRP protein and mRNA expression in HepG2 cells, and this effect of IL-6 can be decreased by UA (6.25, 12.5, 25 mumol/L) markedly in a dose-dependent manner.	ursolic acid	132-134	interleukin 6	Homo sapiens	107-111
22108347-9	2012	CRP can obviously increase LOX-1/VCAM-1 expression in HUVECs, both on mRNA and protein levels and the effect of CRP can be inhibited by UA (5, 10, 20 mumol/L) in a dose-dependent manner.	ursolic acid	136-138	vascular cell adhesion molecule 1	Homo sapiens	33-39
22108347-9	2012	CRP can obviously increase LOX-1/VCAM-1 expression in HUVECs, both on mRNA and protein levels and the effect of CRP can be inhibited by UA (5, 10, 20 mumol/L) in a dose-dependent manner.	ursolic acid	136-138	C-reactive protein	Homo sapiens	112-115
22108347-10	2012	CONCLUSION: UA can reduce the over expression of CRP in HepG2 cells induced by IL-6 and inhibit the increased expression of VCAM-1 and LOX-1 in HUVECs caused by CRP.	ursolic acid	12-14	C-reactive protein	Homo sapiens	49-52
22108347-10	2012	CONCLUSION: UA can reduce the over expression of CRP in HepG2 cells induced by IL-6 and inhibit the increased expression of VCAM-1 and LOX-1 in HUVECs caused by CRP.	ursolic acid	12-14	interleukin 6	Homo sapiens	79-83
22108347-10	2012	CONCLUSION: UA can reduce the over expression of CRP in HepG2 cells induced by IL-6 and inhibit the increased expression of VCAM-1 and LOX-1 in HUVECs caused by CRP.	ursolic acid	12-14	vascular cell adhesion molecule 1	Homo sapiens	124-130
22108347-10	2012	CONCLUSION: UA can reduce the over expression of CRP in HepG2 cells induced by IL-6 and inhibit the increased expression of VCAM-1 and LOX-1 in HUVECs caused by CRP.	ursolic acid	12-14	oxidized low density lipoprotein receptor 1	Homo sapiens	135-140
22108347-10	2012	CONCLUSION: UA can reduce the over expression of CRP in HepG2 cells induced by IL-6 and inhibit the increased expression of VCAM-1 and LOX-1 in HUVECs caused by CRP.	ursolic acid	12-14	C-reactive protein	Homo sapiens	161-164
22108347-11	2012	Our research suggests that UA can reduce CRP levels in plasma and prevent inflammatory cytokines from injuring endothelial cells by inhibiting the hepatic synthesis of CRP.	ursolic acid	27-29	C-reactive protein	Homo sapiens	41-44
22108347-11	2012	Our research suggests that UA can reduce CRP levels in plasma and prevent inflammatory cytokines from injuring endothelial cells by inhibiting the hepatic synthesis of CRP.	ursolic acid	27-29	C-reactive protein	Homo sapiens	168-171
22791147-0	2012	Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells.	ursolic acid	0-12	caspase 9	Homo sapiens	74-82
22791147-0	2012	Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells.	ursolic acid	0-12	glycogen synthase kinase 3 beta	Homo sapiens	106-137
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	poly(ADP-ribose) polymerase 1	Homo sapiens	78-105
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	poly(ADP-ribose) polymerase 1	Homo sapiens	107-111
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	caspase 9	Homo sapiens	114-130
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	186-189
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	BCL2 like 1	Homo sapiens	191-199
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	metadherin	Homo sapiens	204-235
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	mitogen-activated protein kinase 1	Homo sapiens	272-309
22791147-7	2012	Consistently, Western blotting revealed that ursolic acid effectively cleaved poly(ADP-ribose) polymerase (PARP), caspase-9 and -3, suppressed the expression of survival genes such as c-Myc, Bcl-x(L) and astrocyte elevated gene (AEG)-1, and upregulated phosphorylation of extracellular signal-regulated kinase (ERK) in SK-OV-3 cells.	ursolic acid	45-57	mitogen-activated protein kinase 1	Homo sapiens	311-314
22791147-8	2012	Interestingly, ursolic acid suppressed beta-catenin degradation as well as enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK 3beta).	ursolic acid	15-27	catenin beta 1	Homo sapiens	39-51
22791147-8	2012	Interestingly, ursolic acid suppressed beta-catenin degradation as well as enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK 3beta).	ursolic acid	15-27	glycogen synthase kinase 3 beta	Homo sapiens	103-134
22791147-8	2012	Interestingly, ursolic acid suppressed beta-catenin degradation as well as enhanced phosphorylation of glycogen synthase kinase 3 beta (GSK 3beta).	ursolic acid	15-27	glycogen synthase kinase 3 beta	Homo sapiens	136-145
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	97-109	glycogen synthase kinase 3 beta	Homo sapiens	13-22
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	97-109	caspase 3	Homo sapiens	67-76
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	97-109	poly(ADP-ribose) polymerase 1	Homo sapiens	81-85
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	97-109	caspase 3	Homo sapiens	199-208
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	273-285	glycogen synthase kinase 3 beta	Homo sapiens	13-22
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	273-285	caspase 3	Homo sapiens	67-76
22791147-9	2012	Furthermore, GSK 3beta inhibitor SB216763 blocked the cleavages of caspase-3 and PARP induced by ursolic acid and proteosomal inhibitor MG132 disturbed down-regulation of beta-catenin, activation of caspase-3 and decreased mitochondrial membrane potential (MMP) induced by ursolic acid in SK-OV-3 cells.	ursolic acid	273-285	poly(ADP-ribose) polymerase 1	Homo sapiens	81-85
22791147-10	2012	Overall, our findings suggest that ursolic acid induces apoptosis via activation of caspase and phosphorylation of GSK 3beta in SK-OV-3 cancer cells as a potent anti-cancer agent for ovarian cancer therapy.	ursolic acid	35-47	caspase 9	Homo sapiens	84-91
22791147-10	2012	Overall, our findings suggest that ursolic acid induces apoptosis via activation of caspase and phosphorylation of GSK 3beta in SK-OV-3 cancer cells as a potent anti-cancer agent for ovarian cancer therapy.	ursolic acid	35-47	glycogen synthase kinase 3 beta	Homo sapiens	115-124
21994027-7	2012	RESULTS: UA in a dose-dependent manner significantly decreased the proliferation and inhibited the surface expressions of CD69, CD25, and CD71 in murine T lymphocytes upon in vitro activation (P&lt;0.01).	ursolic acid	9-11	CD69 antigen	Mus musculus	122-126
21994027-7	2012	RESULTS: UA in a dose-dependent manner significantly decreased the proliferation and inhibited the surface expressions of CD69, CD25, and CD71 in murine T lymphocytes upon in vitro activation (P&lt;0.01).	ursolic acid	9-11	interleukin 2 receptor, alpha chain	Mus musculus	128-132
21994027-7	2012	RESULTS: UA in a dose-dependent manner significantly decreased the proliferation and inhibited the surface expressions of CD69, CD25, and CD71 in murine T lymphocytes upon in vitro activation (P&lt;0.01).	ursolic acid	9-11	transferrin receptor	Mus musculus	138-142
21994027-10	2012	CONCLUSION: UA is a potent inhibitor for T cell activation and proliferation; these effects are associated with the inhibition of NF-kappaB signaling pathway.	ursolic acid	12-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	ursolic acid	43-55	C-X-C motif chemokine ligand 8	Homo sapiens	148-152
21919561-6	2012	The chloroform active subfraction I (GI50 = 2.97 microg mL-1) yielded betulin (1), betulinic acid (2) and ursolic acid (3) upon purification.	ursolic acid	106-118	L1 cell adhesion molecule	Mus musculus	56-60
21999396-4	2012	Among the constituents, matrine, baicalin, ursolic acid, sodium danshensu, magnolol, honokiol, hesperidin and andrographolide significantly reduced IL-8 and TNF-alpha by human HaCaT keratinocyte cells pretreated with heat-killed P. acnes.	ursolic acid	43-55	tumor necrosis factor	Homo sapiens	157-166
24970122-0	2011	Ursolic Acid Inhibits Na+/K+-ATPase Activity and Prevents TNF-alpha-Induced Gene Expression by Blocking Amino Acid Transport and Cellular Protein Synthesis.	ursolic acid	0-12	tumor necrosis factor	Homo sapiens	58-67
22363615-0	2012	Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-kappaB, AP-1 and NF-AT.	ursolic acid	37-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
22363615-0	2012	Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-kappaB, AP-1 and NF-AT.	ursolic acid	37-49	jun proto-oncogene	Mus musculus	125-129
22363615-2	2012	These properties of UA have been attributed to its ability to suppress NF-kappaB (nuclear factor kappa B) activation.	ursolic acid	20-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
22363615-2	2012	These properties of UA have been attributed to its ability to suppress NF-kappaB (nuclear factor kappa B) activation.	ursolic acid	20-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-104
22363615-3	2012	Since NF-kappaB, in co-ordination with NF-AT (nuclear factor of activated T cells) and AP-1(activator protein-1), is known to regulate inflammatory genes, we hypothesized that UA might exhibit potent anti-inflammatory effects.	ursolic acid	176-178	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	6-15
22363615-3	2012	Since NF-kappaB, in co-ordination with NF-AT (nuclear factor of activated T cells) and AP-1(activator protein-1), is known to regulate inflammatory genes, we hypothesized that UA might exhibit potent anti-inflammatory effects.	ursolic acid	176-178	jun proto-oncogene	Mus musculus	87-111
22363615-10	2012	Treatment of cells with UA prior to allogenic transplantation significantly delayed induction of acute graft-versus-host disease in mice and also significantly reduced the serum levels of pro-inflammatory cytokines IL-6 and IFN-gamma.	ursolic acid	24-26	interleukin 6	Mus musculus	215-219
22363615-10	2012	Treatment of cells with UA prior to allogenic transplantation significantly delayed induction of acute graft-versus-host disease in mice and also significantly reduced the serum levels of pro-inflammatory cytokines IL-6 and IFN-gamma.	ursolic acid	24-26	interferon gamma	Mus musculus	224-233
21703625-0	2011	Ursolic acid causes DNA-damage, p53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo.	ursolic acid	0-12	tumor protein p53	Homo sapiens	32-35
21703625-4	2011	UA causes DNA-damage, followed by the activation of a p53-, BAK-, and caspase-dependent cell-death pathway.	ursolic acid	0-2	tumor protein p53	Homo sapiens	54-77
21703625-5	2011	Oral application of UA in APO E knockout mice potently stimulated atherosclerotic plaque formation in vivo, which was correlated with decreased serum levels of the athero-protective cytokine IL-5.	ursolic acid	20-22	apolipoprotein E	Mus musculus	26-31
21703625-5	2011	Oral application of UA in APO E knockout mice potently stimulated atherosclerotic plaque formation in vivo, which was correlated with decreased serum levels of the athero-protective cytokine IL-5.	ursolic acid	20-22	interleukin 5	Mus musculus	191-195
21717139-6	2011	Therefore, the present results suggested that the potential drug interaction between danshensu or ursolic acid and rosuvastatin may be mediated by one or more transporters (OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP) and/or CYPs.	ursolic acid	98-110	solute carrier organic anion transporter family member 1B1	Homo sapiens	173-180
21717139-6	2011	Therefore, the present results suggested that the potential drug interaction between danshensu or ursolic acid and rosuvastatin may be mediated by one or more transporters (OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP) and/or CYPs.	ursolic acid	98-110	solute carrier organic anion transporter family member 1B3	Homo sapiens	182-190
21717139-6	2011	Therefore, the present results suggested that the potential drug interaction between danshensu or ursolic acid and rosuvastatin may be mediated by one or more transporters (OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP) and/or CYPs.	ursolic acid	98-110	solute carrier organic anion transporter family member 1A2	Homo sapiens	192-200
21717139-6	2011	Therefore, the present results suggested that the potential drug interaction between danshensu or ursolic acid and rosuvastatin may be mediated by one or more transporters (OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP) and/or CYPs.	ursolic acid	98-110	BCR pseudogene 1	Homo sapiens	202-206
21717139-6	2011	Therefore, the present results suggested that the potential drug interaction between danshensu or ursolic acid and rosuvastatin may be mediated by one or more transporters (OATP1B1, OATP 1B3, OATP 1A2, BCRP and NTCP) and/or CYPs.	ursolic acid	98-110	solute carrier family 10 member 1	Rattus norvegicus	211-215
22745735-2	2012	We recently found that ursolic acid increases skeletal muscle Akt activity and stimulates muscle growth in non-obese mice.	ursolic acid	23-35	thymoma viral proto-oncogene 1	Mus musculus	62-65
22745735-3	2012	Here, we tested the hypothesis that ursolic acid might increase skeletal muscle Akt activity in a mouse model of diet-induced obesity.	ursolic acid	36-48	thymoma viral proto-oncogene 1	Mus musculus	80-83
22745735-5	2012	In skeletal muscle, ursolic acid increased Akt activity, as well as downstream mRNAs that promote glucose utilization (hexokinase-II), blood vessel recruitment (Vegfa) and autocrine/paracrine IGF-I signaling (Igf1).	ursolic acid	20-32	thymoma viral proto-oncogene 1	Mus musculus	43-46
22745735-5	2012	In skeletal muscle, ursolic acid increased Akt activity, as well as downstream mRNAs that promote glucose utilization (hexokinase-II), blood vessel recruitment (Vegfa) and autocrine/paracrine IGF-I signaling (Igf1).	ursolic acid	20-32	vascular endothelial growth factor A	Mus musculus	161-166
22745735-5	2012	In skeletal muscle, ursolic acid increased Akt activity, as well as downstream mRNAs that promote glucose utilization (hexokinase-II), blood vessel recruitment (Vegfa) and autocrine/paracrine IGF-I signaling (Igf1).	ursolic acid	20-32	insulin-like growth factor 1	Mus musculus	209-213
22427843-0	2012	Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.	ursolic acid	0-12	tumor necrosis factor receptor superfamily, member 25	Mus musculus	98-103
22427843-3	2012	We found that TRAMP mice fed with UA diet for 8 weeks (weeks 4 to 12) delayed formation of prostate intraepithelial neoplasia (PIN).	ursolic acid	34-36	tumor necrosis factor receptor superfamily, member 25	Mus musculus	14-19
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	signal transducer and activator of transcription 3	Mus musculus	144-149
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	thymoma viral proto-oncogene 1	Mus musculus	151-154
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	conserved helix-loop-helix ubiquitous kinase	Mus musculus	159-167
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	tumor necrosis factor	Mus musculus	286-295
22427843-6	2012	With respect to the molecular mechanism, we found that UA down-regulated activation of various pro-inflammatory mediators including, NF-kappaB, STAT3, AKT and IKKalpha/beta phosphorylation in the dorsolateral prostate (DLP) tissues that correlated with the reduction in serum levels of TNF-alpha and IL-6.	ursolic acid	55-57	interleukin 6	Mus musculus	300-304
22427843-7	2012	In addition, UA significantly down-regulated the expression levels of cyclin D1 and COX-2 but up-regulated the levels of caspase-3 as revealed by immunohistochemical analysis of tumor tissue sections.	ursolic acid	13-15	cyclin D1	Mus musculus	70-79
22427843-7	2012	In addition, UA significantly down-regulated the expression levels of cyclin D1 and COX-2 but up-regulated the levels of caspase-3 as revealed by immunohistochemical analysis of tumor tissue sections.	ursolic acid	13-15	cytochrome c oxidase II, mitochondrial	Mus musculus	84-89
22427843-7	2012	In addition, UA significantly down-regulated the expression levels of cyclin D1 and COX-2 but up-regulated the levels of caspase-3 as revealed by immunohistochemical analysis of tumor tissue sections.	ursolic acid	13-15	caspase 3	Mus musculus	121-130
23600297-0	2012	[Ursolic acid as antitumor agent and inductor of PTEN and brown fat].	ursolic acid	1-13	phosphatase and tensin homolog	Homo sapiens	49-53
23600297-2	2012	Beside inhibiting tumor cell growth in vitro and in vivo and activating of apoptosis, UA (as well as some other related and not related compounds) is capable to induce PTEN (a tumor suppressor mutation of which is rather often discovered in human tumors including endometrial cancer type I) and amount/activity of brown fat.	ursolic acid	86-88	phosphatase and tensin homolog	Homo sapiens	168-172
21752377-3	2011	METHODS AND RESULTS: Dietary supplementation with either RES or UA (0.2%) protected against accelerated atherosclerosis induced by streptozotocin in high-fat diet-fed LDL receptor-deficient mice.	ursolic acid	64-66	low density lipoprotein receptor	Mus musculus	167-179
21752377-5	2011	Importantly, UA was also significantly more effective in preventing the appearance of proinflammatory GR-1(high) monocytes induced by these diabetic conditions and reducing monocyte recruitment into MCP-1-loaded Matrigel plugs implanted into these diabetic mice.	ursolic acid	13-15	chemokine (C-C motif) ligand 2	Mus musculus	199-204
21752377-7	2011	Pretreatment of THP-1 monocytes with RES or UA (0.3-10muM) for 15h resulted in the dose-dependent inhibition of H(2)O(2)-accelerated chemotaxis in response to MCP-1, but with an IC(50) of 0.4muM, UA was 2.7-fold more potent than RES.	ursolic acid	44-46	chemokine (C-C motif) ligand 2	Mus musculus	159-164
21752377-7	2011	Pretreatment of THP-1 monocytes with RES or UA (0.3-10muM) for 15h resulted in the dose-dependent inhibition of H(2)O(2)-accelerated chemotaxis in response to MCP-1, but with an IC(50) of 0.4muM, UA was 2.7-fold more potent than RES.	ursolic acid	196-198	chemokine (C-C motif) ligand 2	Mus musculus	159-164
24970122-2	2011	Ursolic acid (3beta-hydroxy-urs-12-en-28-oic acid) was identified to inhibit the cell-surface ICAM-1 expression induced by pro-inflammatory cytokines in human lung carcinoma A549 cells.	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	94-100
24970122-2	2011	Ursolic acid (3beta-hydroxy-urs-12-en-28-oic acid) was identified to inhibit the cell-surface ICAM-1 expression induced by pro-inflammatory cytokines in human lung carcinoma A549 cells.	ursolic acid	14-49	intercellular adhesion molecule 1	Homo sapiens	94-100
24970122-3	2011	Ursolic acid was found to inhibit the TNF-alpha-induced ICAM-1 protein expression almost completely, whereas the TNF-alpha-induced ICAM-1 mRNA expression and NF-kappaB signaling pathway were decreased only partially by ursolic acid.	ursolic acid	0-12	tumor necrosis factor	Homo sapiens	38-47
24970122-3	2011	Ursolic acid was found to inhibit the TNF-alpha-induced ICAM-1 protein expression almost completely, whereas the TNF-alpha-induced ICAM-1 mRNA expression and NF-kappaB signaling pathway were decreased only partially by ursolic acid.	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	56-62
24970122-3	2011	Ursolic acid was found to inhibit the TNF-alpha-induced ICAM-1 protein expression almost completely, whereas the TNF-alpha-induced ICAM-1 mRNA expression and NF-kappaB signaling pathway were decreased only partially by ursolic acid.	ursolic acid	219-231	tumor necrosis factor	Homo sapiens	38-47
24970122-3	2011	Ursolic acid was found to inhibit the TNF-alpha-induced ICAM-1 protein expression almost completely, whereas the TNF-alpha-induced ICAM-1 mRNA expression and NF-kappaB signaling pathway were decreased only partially by ursolic acid.	ursolic acid	219-231	tumor necrosis factor	Homo sapiens	113-122
24970122-3	2011	Ursolic acid was found to inhibit the TNF-alpha-induced ICAM-1 protein expression almost completely, whereas the TNF-alpha-induced ICAM-1 mRNA expression and NF-kappaB signaling pathway were decreased only partially by ursolic acid.	ursolic acid	219-231	intercellular adhesion molecule 1	Homo sapiens	131-137
24970122-7	2011	Thus, our present study reveals a novel molecular mechanism in which ursolic acid inhibits Na+/K+-ATPase activity and prevents the TNF-alpha-induced gene expression by blocking amino acid transport and cellular protein synthesis.	ursolic acid	69-81	tumor necrosis factor	Homo sapiens	131-140
21855333-2	2011	Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-alpha; however, ursolic acid enhances the binding of PPAR-alpha to the peroxisome proliferator response element in PPAR-alpha-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes.	ursolic acid	188-200	peroxisome proliferator activated receptor alpha	Homo sapiens	225-235
21708244-0	2011	Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IkappaB kinase beta/nuclear factor-kappaB-mediated inflammatory pathways in mice.	ursolic acid	0-12	inhibitor of kappaB kinase beta	Mus musculus	111-130
21855333-0	2011	Ursolic acid is a PPAR-alpha agonist that regulates hepatic lipid metabolism.	ursolic acid	0-12	peroxisome proliferator activated receptor alpha	Homo sapiens	18-28
21846839-5	2011	We isolated three compounds, ursolic acid, oleanolic acid, and 8-trans-p-coumaroyloxy-alpha-terpineol, which inhibited estradiol-17beta-glucuronide uptake by OATP1B1 but not OATP1B3.	ursolic acid	29-41	solute carrier organic anion transporter family member 1B1	Homo sapiens	158-165
21846839-5	2011	We isolated three compounds, ursolic acid, oleanolic acid, and 8-trans-p-coumaroyloxy-alpha-terpineol, which inhibited estradiol-17beta-glucuronide uptake by OATP1B1 but not OATP1B3.	ursolic acid	29-41	solute carrier organic anion transporter family member 1B3	Homo sapiens	174-181
21432926-10	2011	Only UA tested at 100 muM showed potent antagonistic activity towards TRPV1.	ursolic acid	5-7	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
21855333-2	2011	Surface plasmon resonance and time-resolved fluorescence resonance energy transfer analyses do not show direct binding of ursolic acid to the ligand-binding domain of PPAR-alpha; however, ursolic acid enhances the binding of PPAR-alpha to the peroxisome proliferator response element in PPAR-alpha-responsive genes, alters the expression of key genes in lipid metabolism, significantly reducing intracellular triglyceride and cholesterol concentrations in hepatocytes.	ursolic acid	188-200	peroxisome proliferator activated receptor alpha	Homo sapiens	225-235
21855333-1	2011	In this study, we confirmed that ursolic acid, a plant triterpenoid, activates peroxisome proliferator-activated receptor (PPAR)-alpha in vitro.	ursolic acid	33-45	peroxisome proliferator activated receptor alpha	Homo sapiens	79-134
21855333-3	2011	Thus, ursolic acid is a PPAR-alpha agonist that regulates the expression of lipid metabolism genes, but it is not a direct ligand of PPAR-alpha.	ursolic acid	6-18	peroxisome proliferator activated receptor alpha	Homo sapiens	24-34
21480220-0	2011	Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.	ursolic acid	45-57	chemokine (C-X-C motif) receptor 4	Mus musculus	14-19
21480220-0	2011	Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.	ursolic acid	45-57	chemokine (C-X-C motif) ligand 12	Mus musculus	20-26
21480220-3	2011	In this report, we tested an agent, ursolic acid (UA) for its ability to modulate CXCR4 expression in prostate cancer cell lines and inhibit metastasis in vivo in transgenic adenocarcinoma of mouse prostate (TRAMP) model.	ursolic acid	36-48	chemokine (C-X-C motif) receptor 4	Mus musculus	82-87
21480220-3	2011	In this report, we tested an agent, ursolic acid (UA) for its ability to modulate CXCR4 expression in prostate cancer cell lines and inhibit metastasis in vivo in transgenic adenocarcinoma of mouse prostate (TRAMP) model.	ursolic acid	36-48	tumor necrosis factor receptor superfamily, member 25	Mus musculus	208-213
21480220-3	2011	In this report, we tested an agent, ursolic acid (UA) for its ability to modulate CXCR4 expression in prostate cancer cell lines and inhibit metastasis in vivo in transgenic adenocarcinoma of mouse prostate (TRAMP) model.	ursolic acid	50-52	chemokine (C-X-C motif) receptor 4	Mus musculus	82-87
21480220-3	2011	In this report, we tested an agent, ursolic acid (UA) for its ability to modulate CXCR4 expression in prostate cancer cell lines and inhibit metastasis in vivo in transgenic adenocarcinoma of mouse prostate (TRAMP) model.	ursolic acid	50-52	tumor necrosis factor receptor superfamily, member 25	Mus musculus	208-213
21480220-4	2011	We observed that UA downregulated the expression of CXCR4 in prostate cancer cells irrespective of their HER2 status in a dose- and time-dependent manner.	ursolic acid	17-19	chemokine (C-X-C motif) receptor 4	Mus musculus	52-57
21480220-8	2011	Finally, we also found that UA treatment can inhibit metastasis of prostate cancer to distal organs, including lung and liver and suppress CXCR4 expression levels in the prostate tissues of TRAMP mice.	ursolic acid	28-30	chemokine (C-X-C motif) receptor 4	Mus musculus	139-144
21480220-8	2011	Finally, we also found that UA treatment can inhibit metastasis of prostate cancer to distal organs, including lung and liver and suppress CXCR4 expression levels in the prostate tissues of TRAMP mice.	ursolic acid	28-30	tumor necrosis factor receptor superfamily, member 25	Mus musculus	190-195
21480220-9	2011	Overall, our experimental findings suggest that UA exerts its antimetastatic effects through the suppression of CXCR4 expression in prostate cancer both in vitro and in vivo.	ursolic acid	48-50	chemokine (C-X-C motif) receptor 4	Mus musculus	112-117
21417964-6	2011	In addition, the chemical modifications of ursolic acid to make more effective and water soluble derivatives, previous and current information regarding, its natural and semisynthetic analogs, focusing on its anticancer, cytotoxic, antitumor, antioxidant, anti-inflammatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, and hepatoprotective activities, briefly discussion is attempted here for its research perspectives.	ursolic acid	43-55	butyrylcholinesterase	Homo sapiens	292-306
21417964-6	2011	In addition, the chemical modifications of ursolic acid to make more effective and water soluble derivatives, previous and current information regarding, its natural and semisynthetic analogs, focusing on its anticancer, cytotoxic, antitumor, antioxidant, anti-inflammatory, anti-HIV, acetyl cholinesterase, alpha-glucosidase, antimicrobial, and hepatoprotective activities, briefly discussion is attempted here for its research perspectives.	ursolic acid	43-55	sucrase-isomaltase	Homo sapiens	308-325
21539908-6	2011	UA concentration-dependently suppressed ICAM-1 expression (P&lt;0.05).	ursolic acid	0-2	intercellular adhesion molecule 1	Homo sapiens	40-46
21539908-8	2011	UA treatments significantly suppressed the expression of MMP-9 and MMP-2 (P&lt;0.05), and inhibited protein kinase C activity in test cell lines (P&lt;0.05).	ursolic acid	0-2	matrix metallopeptidase 9	Homo sapiens	57-62
21539908-8	2011	UA treatments significantly suppressed the expression of MMP-9 and MMP-2 (P&lt;0.05), and inhibited protein kinase C activity in test cell lines (P&lt;0.05).	ursolic acid	0-2	matrix metallopeptidase 2	Homo sapiens	67-72
22332359-0	2011	Inhibitory effect of ursolic acid derivatives on recombinant human aldose reductase.	ursolic acid	21-33	aldo-keto reductase family 1 member B	Homo sapiens	67-83
21496491-0	2011	Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-kappaB mediated inflammatory pathways.	ursolic acid	0-12	mitogen-activated protein kinase 14	Mus musculus	105-108
22332359-6	2011	Ursolic acid derivative N-(3beta-hydroxyurs-12-en-28-oyl)-4-aminobutyric acid is able to inhibit rhAR uncompetitively and could be offered as a lead compound for AR inhibition.	ursolic acid	0-12	aldo-keto reductase family 1 member B	Homo sapiens	99-101
21496491-0	2011	Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-kappaB mediated inflammatory pathways.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-118
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	51-63
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	107-110
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	mitogen-activated protein kinase 14	Mus musculus	137-140
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	myeloid differentiation primary response gene 88	Mus musculus	211-216
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	mitogen-activated protein kinase 1	Mus musculus	218-221
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	mitogen-activated protein kinase 8	Mus musculus	223-226
21496491-6	2011	Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt.	ursolic acid	17-19	thymoma viral proto-oncogene 1	Mus musculus	231-234
21496491-7	2011	Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-kappaB signaling pathways.	ursolic acid	43-45	mitogen-activated protein kinase 14	Mus musculus	205-208
21496491-7	2011	Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-kappaB signaling pathways.	ursolic acid	43-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	209-218
21910059-5	2011	In our study, we found that ursolic acid induced the appearance of Fas receptor and cleavage of caspase-8, -3 and PARP.	ursolic acid	28-40	caspase 8	Homo sapiens	96-109
21910059-5	2011	In our study, we found that ursolic acid induced the appearance of Fas receptor and cleavage of caspase-8, -3 and PARP.	ursolic acid	28-40	collagen type XI alpha 2 chain	Homo sapiens	114-118
21910059-6	2011	We also found that ursolic acid induced Bax up-regulation and Bcl-2 down-regulation and release of cytochrome C to the cytosol from mitochondria.	ursolic acid	19-31	BCL2 associated X, apoptosis regulator	Homo sapiens	40-43
21910059-6	2011	We also found that ursolic acid induced Bax up-regulation and Bcl-2 down-regulation and release of cytochrome C to the cytosol from mitochondria.	ursolic acid	19-31	BCL2 apoptosis regulator	Homo sapiens	62-67
21910059-6	2011	We also found that ursolic acid induced Bax up-regulation and Bcl-2 down-regulation and release of cytochrome C to the cytosol from mitochondria.	ursolic acid	19-31	cytochrome c, somatic	Homo sapiens	99-111
21910059-7	2011	Moreover, ursolic acid cleaved caspase-9 and decreased mitochondrial membrane potential (DeltaPsim) as shown with JC-1 staining.	ursolic acid	10-22	caspase 9	Homo sapiens	31-40
21465181-2	2011	In this study, we investigated the effect of ursolic acid (UA) on NF-kappaB and STAT3 signaling pathways in both androgen-independent (DU145) and androgen-dependent (LNCaP) prostate cancer cell lines and also prospectively tested the hypothesis of NF-kappaB and STAT3 inhibition using a virtual predictive functional proteomics tumor pathway technology platform.	ursolic acid	45-57	signal transducer and activator of transcription 3	Homo sapiens	80-85
21826595-5	2011	After SW480 cells were treated by UA at the concentrations of 0-40 mumol/L for 48 h, FCM showed that annexin V (AV) positive cells and hypodiploid peak ratio increased along with the increase in the drug"s concentrations; and Western blot found that expressions of Bcl-2, Bcl-xL and survivin decreased in a concentration-dependent manner.	ursolic acid	34-36	annexin A5	Homo sapiens	101-110
21826595-5	2011	After SW480 cells were treated by UA at the concentrations of 0-40 mumol/L for 48 h, FCM showed that annexin V (AV) positive cells and hypodiploid peak ratio increased along with the increase in the drug"s concentrations; and Western blot found that expressions of Bcl-2, Bcl-xL and survivin decreased in a concentration-dependent manner.	ursolic acid	34-36	BCL2 apoptosis regulator	Homo sapiens	265-270
21826595-5	2011	After SW480 cells were treated by UA at the concentrations of 0-40 mumol/L for 48 h, FCM showed that annexin V (AV) positive cells and hypodiploid peak ratio increased along with the increase in the drug"s concentrations; and Western blot found that expressions of Bcl-2, Bcl-xL and survivin decreased in a concentration-dependent manner.	ursolic acid	34-36	BCL2 like 1	Homo sapiens	272-278
21168456-4	2011	The cell killing effect of UA on activated HSCs in rats chronically treated with thioacetamide (TAA) was detected by dual staining of TdT-mediated dUTP nick-end labeling (TUNEL) and smooth muscle alpha-actin (alphaSMA) immunohistochemistry, and resolution of hepatic fibrosis was evaluated.	ursolic acid	27-29	actin alpha 2, smooth muscle	Rattus norvegicus	182-207
21168456-7	2011	Mitochodrial permeability transition (MPT) preceded the cleavage of caspase-3 and -9 following UA treatment.	ursolic acid	95-97	caspase 3	Rattus norvegicus	68-84
21168456-8	2011	UA also decreased phosphorylation levels of Akt, and diminished nuclear localization of NFkappaB in these cells.	ursolic acid	0-2	AKT serine/threonine kinase 1	Rattus norvegicus	44-47
21465181-2	2011	In this study, we investigated the effect of ursolic acid (UA) on NF-kappaB and STAT3 signaling pathways in both androgen-independent (DU145) and androgen-dependent (LNCaP) prostate cancer cell lines and also prospectively tested the hypothesis of NF-kappaB and STAT3 inhibition using a virtual predictive functional proteomics tumor pathway technology platform.	ursolic acid	59-61	signal transducer and activator of transcription 3	Homo sapiens	80-85
21465181-3	2011	We found that UA inhibited constitutive and TNF-alpha-induced activation of NF-kappaB in DU145 and LNCaP cells in a dose-dependent manner.	ursolic acid	14-16	tumor necrosis factor	Homo sapiens	44-53
21465181-5	2011	Furthermore, UA suppressed both constitutive and inducible STAT3 activation in prostate cancer cells concomitant with suppression of activation of upstream kinases (Src and JAK2) and STAT3-dependent reporter gene activity.	ursolic acid	13-15	signal transducer and activator of transcription 3	Homo sapiens	59-64
21465181-5	2011	Furthermore, UA suppressed both constitutive and inducible STAT3 activation in prostate cancer cells concomitant with suppression of activation of upstream kinases (Src and JAK2) and STAT3-dependent reporter gene activity.	ursolic acid	13-15	Janus kinase 2	Homo sapiens	173-177
21465181-5	2011	Furthermore, UA suppressed both constitutive and inducible STAT3 activation in prostate cancer cells concomitant with suppression of activation of upstream kinases (Src and JAK2) and STAT3-dependent reporter gene activity.	ursolic acid	13-15	signal transducer and activator of transcription 3	Homo sapiens	183-188
21465181-6	2011	UA also downregulated the expression of various NF-kappaB and STAT3 regulated gene products involved in proliferation, survival, and angiogenesis and induced apoptosis in both cells lines as evidenced by DNA fragmentation and annexin V staining.	ursolic acid	0-2	signal transducer and activator of transcription 3	Homo sapiens	62-67
21465181-9	2011	Overall, our results from experimental and predictive studies suggest that UA mediates its anti-tumor effects through suppression of NF-kappaB and STAT3 pathways in prostate cancer.	ursolic acid	75-77	signal transducer and activator of transcription 3	Homo sapiens	147-152
21251952-0	2011	HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death.	ursolic acid	78-90	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
21442679-3	2011	In this study, the effects of oleanolic acid and ursolic acid on MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) from human airway epithelial cells were investigated.	ursolic acid	49-61	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	65-71
21442679-3	2011	In this study, the effects of oleanolic acid and ursolic acid on MUC5AC mucin production and gene expression induced by epidermal growth factor (EGF) and phorbol 12-myristate 13-acetate (PMA) from human airway epithelial cells were investigated.	ursolic acid	49-61	LOC100508689	Homo sapiens	72-77
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	ursolic acid	19-31	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	72-78
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	ursolic acid	19-31	LOC100508689	Homo sapiens	79-84
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	ursolic acid	19-31	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	169-175
21442679-6	2011	Oleanolic acid and ursolic acid were found to inhibit the production of MUC5AC mucin protein induced by EGF and PMA, and both compounds also inhibited the expression of MUC5AC mucin gene induced by EGF and PMA.	ursolic acid	19-31	LOC100508689	Homo sapiens	176-181
21442679-7	2011	These results suggest that oleanolic acid and ursolic acid can regulate mucin gene expression, and production of mucin protein, by directly acting on airway epithelial cells.	ursolic acid	46-58	LOC100508689	Homo sapiens	72-77
21442679-7	2011	These results suggest that oleanolic acid and ursolic acid can regulate mucin gene expression, and production of mucin protein, by directly acting on airway epithelial cells.	ursolic acid	46-58	LOC100508689	Homo sapiens	113-118
21555221-1	2011	A series of bromo-retrochalcones was designed, synthesized and evaluated as PTP1B inhibitors based on licochalcone A and E. Compounds 6, 12, 13, 14, 25, 36, 37, 39, and 41 showed potent inhibitory effects against PTP1B, and compound 37, the most potent among the series, had an IC(50) value of 1.9 muM, about two-fold better than that of the positive control, ursolic acid.	ursolic acid	360-372	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	76-81
21251952-4	2011	In this study, we focused our interest on the role played by COX-2 in apoptosis induced in HT-29 human colorectal cancer cells by ursolic acid (UA), a triterpenoid found in a large variety of plants.	ursolic acid	130-142	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
21251952-4	2011	In this study, we focused our interest on the role played by COX-2 in apoptosis induced in HT-29 human colorectal cancer cells by ursolic acid (UA), a triterpenoid found in a large variety of plants.	ursolic acid	144-146	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-66
21251952-8	2011	These results demonstrated that COX-2 was involved in a resistance mechanism to UA-induced apoptosis in HT-29 cells.	ursolic acid	80-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	32-37
21156789-14	2011	Overall, our results showed that UA potentiates TRAIL-induced apoptosis through activation of ROS and JNK-mediated up-regulation of DRs and down-regulation of DcR2 and cell survival proteins.	ursolic acid	33-35	TNF superfamily member 10	Homo sapiens	48-53
21351105-8	2011	Ursolic acid and its esters inhibited tumor cell growth at micromolar concentrations, and inhibited MMP-2 and MMP-9 activity at concentrations below those previously reported for cranberry polyphenolics.	ursolic acid	0-12	matrix metallopeptidase 2	Homo sapiens	100-105
21351105-8	2011	Ursolic acid and its esters inhibited tumor cell growth at micromolar concentrations, and inhibited MMP-2 and MMP-9 activity at concentrations below those previously reported for cranberry polyphenolics.	ursolic acid	0-12	matrix metallopeptidase 9	Homo sapiens	110-115
21547674-7	2011	Moreover, we isolated the compounds ursolic acid and 2alpha-hydroxyursolic acid from LEJ and both compounds also significantly suppressed MMP-2 and MMP-9 activities, indicating that they are the active components of LEJ.	ursolic acid	36-48	matrix metallopeptidase 2	Mus musculus	138-143
21547674-7	2011	Moreover, we isolated the compounds ursolic acid and 2alpha-hydroxyursolic acid from LEJ and both compounds also significantly suppressed MMP-2 and MMP-9 activities, indicating that they are the active components of LEJ.	ursolic acid	36-48	matrix metallopeptidase 9	Mus musculus	148-153
21156789-0	2011	Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.	ursolic acid	0-12	TNF superfamily member 10	Homo sapiens	52-57
21156789-0	2011	Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.	ursolic acid	0-12	tumor protein p53	Homo sapiens	84-87
21156789-0	2011	Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	187-190
21156789-14	2011	Overall, our results showed that UA potentiates TRAIL-induced apoptosis through activation of ROS and JNK-mediated up-regulation of DRs and down-regulation of DcR2 and cell survival proteins.	ursolic acid	33-35	mitogen-activated protein kinase 8	Homo sapiens	102-105
21156789-2	2011	In the present report, we investigated the effect of ursolic acid (UA), a pentacyclic triterpenoid found in rosemary and holy basil, on apoptosis induced by TRAIL.	ursolic acid	53-65	TNF superfamily member 10	Homo sapiens	157-162
21156789-14	2011	Overall, our results showed that UA potentiates TRAIL-induced apoptosis through activation of ROS and JNK-mediated up-regulation of DRs and down-regulation of DcR2 and cell survival proteins.	ursolic acid	33-35	TNF receptor superfamily member 10d	Homo sapiens	159-163
21156789-2	2011	In the present report, we investigated the effect of ursolic acid (UA), a pentacyclic triterpenoid found in rosemary and holy basil, on apoptosis induced by TRAIL.	ursolic acid	67-69	TNF superfamily member 10	Homo sapiens	157-162
21156789-3	2011	We found that UA potentiated TRAIL-induced apoptosis in cancer cells.	ursolic acid	14-16	TNF superfamily member 10	Homo sapiens	29-34
21156789-4	2011	In addition, UA also sensitized TRAIL-resistant cancer cells to the cytokine.	ursolic acid	13-15	TNF superfamily member 10	Homo sapiens	32-37
21156789-5	2011	When we investigated the mechanism, we found that UA down-regulated cell survival proteins and induced the cell surface expression of both TRAIL receptors, death receptors 4 and 5 (DR4 and -5).	ursolic acid	50-52	TNF receptor superfamily member 10a	Homo sapiens	139-179
22252762-9	2011	Of the two isomeric compounds, UA showed a higher cytotoxic activity against HSF cells than did OA.	ursolic acid	31-33	interleukin 6	Homo sapiens	77-80
21156789-5	2011	When we investigated the mechanism, we found that UA down-regulated cell survival proteins and induced the cell surface expression of both TRAIL receptors, death receptors 4 and 5 (DR4 and -5).	ursolic acid	50-52	TNF receptor superfamily member 10a	Homo sapiens	181-191
21156789-8	2011	In addition, UA also decreased the expression of decoy receptor 2 (DcR2) but not DcR1.	ursolic acid	13-15	TNF receptor superfamily member 10d	Homo sapiens	49-65
21156789-8	2011	In addition, UA also decreased the expression of decoy receptor 2 (DcR2) but not DcR1.	ursolic acid	13-15	TNF receptor superfamily member 10d	Homo sapiens	67-71
21156789-9	2011	Induction of DRs was independent of p53 because UA induced DR4 and DR5 in HCT116 p53(-/-) cells.	ursolic acid	48-50	TNF receptor superfamily member 10a	Homo sapiens	59-62
21156789-9	2011	Induction of DRs was independent of p53 because UA induced DR4 and DR5 in HCT116 p53(-/-) cells.	ursolic acid	48-50	TNF receptor superfamily member 10b	Homo sapiens	67-70
21156789-9	2011	Induction of DRs was independent of p53 because UA induced DR4 and DR5 in HCT116 p53(-/-) cells.	ursolic acid	48-50	tumor protein p53	Homo sapiens	81-84
21156789-10	2011	Induction of DRs, however, was dependent on JNK because UA induced JNK, and its pharmacologic inhibition abolished the induction of the receptors.	ursolic acid	56-58	mitogen-activated protein kinase 8	Homo sapiens	44-47
21156789-10	2011	Induction of DRs, however, was dependent on JNK because UA induced JNK, and its pharmacologic inhibition abolished the induction of the receptors.	ursolic acid	56-58	mitogen-activated protein kinase 8	Homo sapiens	67-70
21156789-12	2011	Also, potentiation of TRAIL-induced apoptosis by UA was significantly reduced by both ROS quenchers and JNK inhibitor.	ursolic acid	49-51	TNF superfamily member 10	Homo sapiens	22-27
21156789-12	2011	Also, potentiation of TRAIL-induced apoptosis by UA was significantly reduced by both ROS quenchers and JNK inhibitor.	ursolic acid	49-51	mitogen-activated protein kinase 8	Homo sapiens	104-107
21156789-13	2011	In addition, UA was also found to induce the expression of DRs, down-regulate cell survival proteins, and activate JNK in orthotopically implanted human colorectal cancer in a nude mouse model.	ursolic acid	13-15	mitogen-activated protein kinase 8	Homo sapiens	115-118
20948428-0	2011	Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPbeta expression by ERK pathway activation.	ursolic acid	0-12	CCAAT enhancer binding protein beta	Homo sapiens	68-77
20948428-0	2011	Ursolic acid induces HL60 monocytic differentiation and upregulates C/EBPbeta expression by ERK pathway activation.	ursolic acid	0-12	mitogen-activated protein kinase 1	Homo sapiens	92-95
20948428-3	2011	UA could induce differentiation of HL60 cells into the monocytic lineage, as assessed by the morphological change, nitroblue tetrazolium reduction assay, and expression of CD14 and CD11b surface antigens.	ursolic acid	0-2	CD14 molecule	Homo sapiens	172-176
20948428-3	2011	UA could induce differentiation of HL60 cells into the monocytic lineage, as assessed by the morphological change, nitroblue tetrazolium reduction assay, and expression of CD14 and CD11b surface antigens.	ursolic acid	0-2	integrin subunit alpha M	Homo sapiens	181-186
20948428-4	2011	Moreover, UA activated the extracellular signal-regulated kinase (ERK) pathway in both dose-dependent and time-dependent manners.	ursolic acid	10-12	mitogen-activated protein kinase 1	Homo sapiens	27-64
20948428-4	2011	Moreover, UA activated the extracellular signal-regulated kinase (ERK) pathway in both dose-dependent and time-dependent manners.	ursolic acid	10-12	mitogen-activated protein kinase 1	Homo sapiens	66-69
20948428-5	2011	Inhibiting ERK pathway activation with PD98059 could significantly block the differentiation induced by UA.	ursolic acid	104-106	mitogen-activated protein kinase 1	Homo sapiens	11-14
20948428-6	2011	Consistent with the induced differentiation, the upregulation of CCAAT/enhancer-binding protein beta by UA was also eliminated by PD98059.	ursolic acid	104-106	CCAAT enhancer binding protein beta	Homo sapiens	65-100
20948428-7	2011	Taken together, the results reported here show that UA can promote the monocytic differentiation of HL60 cells and increase the expression of CCAAT/enhancer-binding protein beta by activating the ERK pathway, suggesting that UA could be a potential candidate as a differentiation-inducing agent for the therapeutic treatment of leukemia.	ursolic acid	52-54	CCAAT enhancer binding protein beta	Homo sapiens	142-177
20948428-7	2011	Taken together, the results reported here show that UA can promote the monocytic differentiation of HL60 cells and increase the expression of CCAAT/enhancer-binding protein beta by activating the ERK pathway, suggesting that UA could be a potential candidate as a differentiation-inducing agent for the therapeutic treatment of leukemia.	ursolic acid	52-54	mitogen-activated protein kinase 1	Homo sapiens	196-199
20948428-7	2011	Taken together, the results reported here show that UA can promote the monocytic differentiation of HL60 cells and increase the expression of CCAAT/enhancer-binding protein beta by activating the ERK pathway, suggesting that UA could be a potential candidate as a differentiation-inducing agent for the therapeutic treatment of leukemia.	ursolic acid	225-227	CCAAT enhancer binding protein beta	Homo sapiens	142-177
20948428-7	2011	Taken together, the results reported here show that UA can promote the monocytic differentiation of HL60 cells and increase the expression of CCAAT/enhancer-binding protein beta by activating the ERK pathway, suggesting that UA could be a potential candidate as a differentiation-inducing agent for the therapeutic treatment of leukemia.	ursolic acid	225-227	mitogen-activated protein kinase 1	Homo sapiens	196-199
20632303-6	2011	Further studies revealed that only oleanolic acid and ursolic acid, but not betulinic acid, could inhibit the lipopolysaccharide induced interleukin-6 release from Mono Mac 6 cells when tested separately.	ursolic acid	54-66	interleukin 6	Homo sapiens	137-150
21122803-0	2011	Ursolic acid increases the secretion of atrial natriuretic peptide in isolated perfused beating rabbit atria.	ursolic acid	0-12	natriuretic peptides A	Oryctolagus cuniculus	40-66
21122803-6	2011	Ursolic acid increased ANP secretion and mechanical dynamics in a concentration-dependent manner.	ursolic acid	0-12	natriuretic peptides A	Oryctolagus cuniculus	23-26
21122803-7	2011	The inhibition of L-type Ca(2+) channels with nifedipine attenuated the ursolic acid-induced increase in ANP secretion but not mechanical dynamics.	ursolic acid	72-84	natriuretic peptides A	Oryctolagus cuniculus	105-108
21122803-8	2011	The inhibition of K(+)(ATP) channels with glibenclamide attenuated the ursolic acid-induced increase in ANP secretion-but not atrial dynamics-in a concentration-dependent manner.	ursolic acid	71-83	natriuretic peptides A	Oryctolagus cuniculus	104-107
21122803-10	2011	These findings show that ursolic acid increases ANP secretion via its activation of K(+)(ATP) channels and subsequent inhibition of Ca(2+) entry through L-type Ca(2+) channels in rabbit atria.	ursolic acid	25-37	natriuretic peptides A	Oryctolagus cuniculus	48-51
20717876-8	2011	The inhibitory potency (IC(50)) of maslinic acid, corosolic acid, and ursolic acid was 7.4, 8.8, and &lt; 10 microM, respectively, using HIM as the enzyme source and 2.8, 4.3, and &lt; 10 microM, respectively, using recombinant CYP3A4 as the enzyme source.	ursolic acid	70-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	228-234
21040770-4	2011	Besides its inhibitory effects against TNFalpha induced expression of VCAM-1 (IC(50) 6.25 muM), ursolic acid inhibits also TNFalpha induced expression of ICAM-1 (IC(50) value between 3.13 and 6.25 muM) (positive control: parthenolide 10 muM, ICAM-1 expression (% of control): 38.89+-16.6%).	ursolic acid	96-108	latexin	Homo sapiens	197-200
21040770-4	2011	Besides its inhibitory effects against TNFalpha induced expression of VCAM-1 (IC(50) 6.25 muM), ursolic acid inhibits also TNFalpha induced expression of ICAM-1 (IC(50) value between 3.13 and 6.25 muM) (positive control: parthenolide 10 muM, ICAM-1 expression (% of control): 38.89+-16.6%).	ursolic acid	96-108	latexin	Homo sapiens	197-200
21040770-6	2011	CONCLUSIONS: Our findings suggest an additional mechanism of the anti-inflammatory activity of ursolic acid by demonstrating its ability to inhibit TNFalpha-stimulated expression of VCAM-1 and ICAM-1 and support the traditional use of extracts and preparations of Sambucus ebulus L., rich in ursolic acid, for the treatment of chronically inflammatory processes.	ursolic acid	95-107	vascular cell adhesion molecule 1	Homo sapiens	182-188
20869956-7	2010	Mice receiving UA or metformin supplementation had increased CD4(+)CD8(+) subpopulations in the thymus compared to the untreated diabetic mice.	ursolic acid	15-17	CD4 antigen	Mus musculus	61-64
21716649-6	2011	UA activated caspase-3, -8, and -9 and down regulated expression of Bcl-2 in BGC-803 cells.	ursolic acid	0-2	caspase 3	Homo sapiens	13-34
21716649-6	2011	UA activated caspase-3, -8, and -9 and down regulated expression of Bcl-2 in BGC-803 cells.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	68-73
21716649-7	2011	The expression of caspase-3 and -8 was elevated in tumor cells from xenograft treated with UA.	ursolic acid	91-93	caspase 3	Homo sapiens	18-34
21716649-8	2011	18F-FLT PET-CT imaging confirmed tumor model and UA effectiveness.	ursolic acid	49-51	fms related receptor tyrosine kinase 1	Homo sapiens	4-7
21070071-0	2010	Ursolic acid induces allograft inflammatory factor-1 expression via a nitric oxide-related mechanism and increases neovascularization.	ursolic acid	0-12	allograft inflammatory factor 1	Homo sapiens	21-52
21070071-7	2010	In vitro data showed that UA increases tube formation and migration capacities in human endothelial cells, and exposing HCECs to UA increased AIF-1 expression through a NO-related mechanism.	ursolic acid	129-131	allograft inflammatory factor 1	Homo sapiens	142-147
21070071-8	2010	Moreover, UA administration increased capillary density and eNOS and AIF-1 expression in ischemic muscle.	ursolic acid	10-12	allograft inflammatory factor 1	Homo sapiens	69-74
20869956-10	2010	Both doses of UA lowered splenic IL-6 levels, whereas metformin increased IFN-gamma, IL-6 and TNF-alpha levels compared to the untreated diabetic mice.	ursolic acid	14-16	interleukin 6	Mus musculus	33-37
20869956-8	2010	Concanavalin A-stimulated splenic T-lymphocyte proliferation and single-positive (CD4(+) and CD8(+)) subpopulations were significantly higher in the UA-supplemented diabetic groups than in the untreated diabetic group, but lipopolysaccharide-stimulated B-lymphocyte proliferation and the CD19(+) subpopulation were not significantly different among the groups.	ursolic acid	149-151	CD4 antigen	Mus musculus	82-85
20869956-8	2010	Concanavalin A-stimulated splenic T-lymphocyte proliferation and single-positive (CD4(+) and CD8(+)) subpopulations were significantly higher in the UA-supplemented diabetic groups than in the untreated diabetic group, but lipopolysaccharide-stimulated B-lymphocyte proliferation and the CD19(+) subpopulation were not significantly different among the groups.	ursolic acid	149-151	CD19 antigen	Mus musculus	288-292
20630652-2	2010	UA could activate Bak but not Bax, which implied that Bak may play an important role in UA-induced apoptosis.	ursolic acid	0-2	BCL2 antagonist/killer 1	Homo sapiens	18-21
20630652-2	2010	UA could activate Bak but not Bax, which implied that Bak may play an important role in UA-induced apoptosis.	ursolic acid	0-2	BCL2 antagonist/killer 1	Homo sapiens	54-57
20630652-2	2010	UA could activate Bak but not Bax, which implied that Bak may play an important role in UA-induced apoptosis.	ursolic acid	88-90	BCL2 antagonist/killer 1	Homo sapiens	18-21
20630652-2	2010	UA could activate Bak but not Bax, which implied that Bak may play an important role in UA-induced apoptosis.	ursolic acid	88-90	BCL2 antagonist/killer 1	Homo sapiens	54-57
20943386-5	2010	After ursolic acid treatment at concentrations above 40 muM, the activities of caspase-3, -8, and -9 were significantly increased compared that of control.	ursolic acid	6-18	latexin	Homo sapiens	56-59
20579861-2	2010	We examined the effects of two pentacyclic triterpenoid acids, ursolic acid (UA) and oleanolic acid (OA), on the expression of E-selectin by cultured human umbilical vein endothelial cells (HUVECs).	ursolic acid	63-75	selectin E	Homo sapiens	127-137
20579861-2	2010	We examined the effects of two pentacyclic triterpenoid acids, ursolic acid (UA) and oleanolic acid (OA), on the expression of E-selectin by cultured human umbilical vein endothelial cells (HUVECs).	ursolic acid	77-79	selectin E	Homo sapiens	127-137
20579861-6	2010	The repression of E-selectin mRNA expression caused by the pentacyclic triterpenoid acids paralleled the inhibition of NF-kappaB activation and nuclear translocation, as evaluated by electrophoretic mobility shift assays, although the degree of repression by UA was approximately two times more effective than that of OA.	ursolic acid	259-261	selectin E	Homo sapiens	18-28
20579861-0	2010	Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-alpha-induced E-selectin expression by cultured umbilical vein endothelial cells.	ursolic acid	0-12	tumor necrosis factor	Homo sapiens	85-94
20579861-0	2010	Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-alpha-induced E-selectin expression by cultured umbilical vein endothelial cells.	ursolic acid	0-12	selectin E	Homo sapiens	103-113
20943386-5	2010	After ursolic acid treatment at concentrations above 40 muM, the activities of caspase-3, -8, and -9 were significantly increased compared that of control.	ursolic acid	6-18	caspase 3	Homo sapiens	79-100
20943386-6	2010	Ursolic acid modulated the upregulation of Bax (pro-apoptotic) as well as the downregulation of Bcl-2 (anti-apoptotic).	ursolic acid	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	43-46
20943386-6	2010	Ursolic acid modulated the upregulation of Bax (pro-apoptotic) as well as the downregulation of Bcl-2 (anti-apoptotic).	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	96-101
20943386-7	2010	Ursolic acid also stimulated Bid cleavage, which indicates that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9.	ursolic acid	0-12	BH3 interacting domain death agonist	Homo sapiens	29-32
20943386-7	2010	Ursolic acid also stimulated Bid cleavage, which indicates that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9.	ursolic acid	0-12	caspase 8	Homo sapiens	88-97
20943386-7	2010	Ursolic acid also stimulated Bid cleavage, which indicates that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9.	ursolic acid	0-12	BH3 interacting domain death agonist	Homo sapiens	107-110
20943386-7	2010	Ursolic acid also stimulated Bid cleavage, which indicates that the apoptotic action of caspase-8-mediated Bid cleavage leads to the activation of caspase-9.	ursolic acid	0-12	caspase 9	Homo sapiens	147-156
20818497-3	2010	Further studies identified that UA treatment suppressed diabetes-induced activations of STAT-3, ERK1/2 and JNK pathways, but not the diabetes-induced activation of the p38 pathway.	ursolic acid	32-34	signal transducer and activator of transcription 3	Mus musculus	88-94
20521271-4	2010	Furthermore, the lipolytic effect of UA was inhibited by the protein kinase A (PKA) specific inhibitor H89, suggesting that UA exerted its lipolytic function through the cAMP-dependent PKA pathway.	ursolic acid	37-39	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	61-77
20521271-4	2010	Furthermore, the lipolytic effect of UA was inhibited by the protein kinase A (PKA) specific inhibitor H89, suggesting that UA exerted its lipolytic function through the cAMP-dependent PKA pathway.	ursolic acid	37-39	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	79-82
20521271-4	2010	Furthermore, the lipolytic effect of UA was inhibited by the protein kinase A (PKA) specific inhibitor H89, suggesting that UA exerted its lipolytic function through the cAMP-dependent PKA pathway.	ursolic acid	37-39	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	185-188
20521271-4	2010	Furthermore, the lipolytic effect of UA was inhibited by the protein kinase A (PKA) specific inhibitor H89, suggesting that UA exerted its lipolytic function through the cAMP-dependent PKA pathway.	ursolic acid	124-126	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	61-77
20521271-4	2010	Furthermore, the lipolytic effect of UA was inhibited by the protein kinase A (PKA) specific inhibitor H89, suggesting that UA exerted its lipolytic function through the cAMP-dependent PKA pathway.	ursolic acid	124-126	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	79-82
20521271-4	2010	Furthermore, the lipolytic effect of UA was inhibited by the protein kinase A (PKA) specific inhibitor H89, suggesting that UA exerted its lipolytic function through the cAMP-dependent PKA pathway.	ursolic acid	124-126	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	185-188
20521271-5	2010	Downstream targets of the PKA pathway, hormone-sensitive lipase (HSL) and perilipin A were checked, UA enhanced lipolysis by promoting the translocation of HSL from the cytosol to the lipid droplets and inhibiting the expression of perilipin A.	ursolic acid	100-102	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	26-29
20521271-5	2010	Downstream targets of the PKA pathway, hormone-sensitive lipase (HSL) and perilipin A were checked, UA enhanced lipolysis by promoting the translocation of HSL from the cytosol to the lipid droplets and inhibiting the expression of perilipin A.	ursolic acid	100-102	lipase E, hormone sensitive type	Rattus norvegicus	156-159
20521271-7	2010	UA-induced expression of ATGL could not be blocked by H89, suggesting that ATGL upregulation is not regulated by the PKA pathway.	ursolic acid	0-2	patatin-like phospholipase domain containing 2	Rattus norvegicus	25-29
20521271-7	2010	UA-induced expression of ATGL could not be blocked by H89, suggesting that ATGL upregulation is not regulated by the PKA pathway.	ursolic acid	0-2	patatin-like phospholipase domain containing 2	Rattus norvegicus	75-79
20521271-8	2010	These findings suggest that UA significantly stimulates lipolysis by translocating HSL, decreasing perilipin A expression by the PKA pathway, and up-regulating ATGL in primary cultured adipocytes.	ursolic acid	28-30	lipase E, hormone sensitive type	Rattus norvegicus	83-86
20521271-8	2010	These findings suggest that UA significantly stimulates lipolysis by translocating HSL, decreasing perilipin A expression by the PKA pathway, and up-regulating ATGL in primary cultured adipocytes.	ursolic acid	28-30	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	129-132
20521271-8	2010	These findings suggest that UA significantly stimulates lipolysis by translocating HSL, decreasing perilipin A expression by the PKA pathway, and up-regulating ATGL in primary cultured adipocytes.	ursolic acid	28-30	patatin-like phospholipase domain containing 2	Rattus norvegicus	160-164
21265099-9	2010	CONCLUSION: UA downregulated the expressions of MMP-2 and MMP-9.	ursolic acid	12-14	matrix metallopeptidase 2	Homo sapiens	48-53
21265099-9	2010	CONCLUSION: UA downregulated the expressions of MMP-2 and MMP-9.	ursolic acid	12-14	matrix metallopeptidase 9	Homo sapiens	58-63
21265099-10	2010	UA inhibits the invasion and metastasis of HO-8910PM cells, probably through inhibiting the activity of gelatinase and the expressions of MMP-2 and MMP-9.	ursolic acid	0-2	matrix metallopeptidase 2	Homo sapiens	138-143
21265099-10	2010	UA inhibits the invasion and metastasis of HO-8910PM cells, probably through inhibiting the activity of gelatinase and the expressions of MMP-2 and MMP-9.	ursolic acid	0-2	matrix metallopeptidase 9	Homo sapiens	148-153
20133359-0	2010	Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-kappaB pathway activation.	ursolic acid	0-12	advanced glycosylation end product-specific receptor	Mus musculus	117-121
20133359-0	2010	Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-kappaB pathway activation.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	122-131
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	integrin alpha M	Mus musculus	151-156
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	nitric oxide synthase 2, inducible	Mus musculus	226-230
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	cytochrome c oxidase II, mitochondrial	Mus musculus	235-240
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	interleukin 1 beta	Mus musculus	256-278
20133359-7	2010	Furthermore, the results also showed that UA significantly reduced the number of activated microglia cells and astrocytes, decreased the expression of CD11b and glial fibrillary acidic protein, downregulated the expression of iNOS and COX-2, and decreased interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha levels in the prefrontal cortex of D-gal-treated mice.	ursolic acid	42-44	interleukin 6	Mus musculus	280-317
20133359-8	2010	Moreover, UA significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-kappaB p65 nuclear translocation in the prefrontal cortex of D-gal-treated mice.	ursolic acid	10-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	127-136
20133359-8	2010	Moreover, UA significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-kappaB p65 nuclear translocation in the prefrontal cortex of D-gal-treated mice.	ursolic acid	10-12	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	137-140
20818497-3	2010	Further studies identified that UA treatment suppressed diabetes-induced activations of STAT-3, ERK1/2 and JNK pathways, but not the diabetes-induced activation of the p38 pathway.	ursolic acid	32-34	mitogen-activated protein kinase 3	Mus musculus	96-102
20818497-3	2010	Further studies identified that UA treatment suppressed diabetes-induced activations of STAT-3, ERK1/2 and JNK pathways, but not the diabetes-induced activation of the p38 pathway.	ursolic acid	32-34	mitogen-activated protein kinase 8	Mus musculus	107-110
20462855-3	2010	The levels of serum vascular endothelial growth factor (VEGF), NO, and proinflammatory cytokines were significantly reduced in ursolic acid-treated animals compared with those in control animals.	ursolic acid	127-139	vascular endothelial growth factor A	Mus musculus	20-54
20352621-0	2010	Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	129-150
20352621-0	2010	Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	152-155
20352621-0	2010	Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun N-terminal kinase, Akt and mammalian target of rapamycin signaling.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	160-189
20352621-5	2010	Ursolic acid suppressed the phosphorylation of Jun N-terminal kinase, Akt and mammalian target of rapamycin, but had no effect on the phosphorylation of ERK and p38.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	47-68
20352621-5	2010	Ursolic acid suppressed the phosphorylation of Jun N-terminal kinase, Akt and mammalian target of rapamycin, but had no effect on the phosphorylation of ERK and p38.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	70-73
20352621-5	2010	Ursolic acid suppressed the phosphorylation of Jun N-terminal kinase, Akt and mammalian target of rapamycin, but had no effect on the phosphorylation of ERK and p38.	ursolic acid	0-12	mechanistic target of rapamycin kinase	Homo sapiens	78-107
20352621-6	2010	Ursolic acid also strongly reduced the levels of NFkappaB p65, c-Jun and c-Fos proteins in the nucleus of MDAMB231 cells.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	49-57
20352621-6	2010	Ursolic acid also strongly reduced the levels of NFkappaB p65, c-Jun and c-Fos proteins in the nucleus of MDAMB231 cells.	ursolic acid	0-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	58-61
20352621-6	2010	Ursolic acid also strongly reduced the levels of NFkappaB p65, c-Jun and c-Fos proteins in the nucleus of MDAMB231 cells.	ursolic acid	0-12	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
20352621-6	2010	Ursolic acid also strongly reduced the levels of NFkappaB p65, c-Jun and c-Fos proteins in the nucleus of MDAMB231 cells.	ursolic acid	0-12	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-78
20352621-7	2010	A time-dependent inhibition of the protein levels of Rho-like GTPases, growth factor receptor-bound protein 2, Ras and vascular endothelial growth factor in cytosol by ursolic acid treatment was also observed.	ursolic acid	168-180	vascular endothelial growth factor A	Homo sapiens	119-153
20352621-8	2010	In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression.	ursolic acid	65-77	mitogen-activated protein kinase 8	Homo sapiens	131-152
20352621-8	2010	In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression.	ursolic acid	65-77	AKT serine/threonine kinase 1	Homo sapiens	154-157
20352621-8	2010	In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression.	ursolic acid	65-77	mechanistic target of rapamycin kinase	Homo sapiens	162-191
20352621-8	2010	In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression.	ursolic acid	65-77	nuclear factor kappa B subunit 1	Homo sapiens	240-248
20352621-8	2010	In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression.	ursolic acid	65-77	matrix metallopeptidase 2	Homo sapiens	313-318
20352621-8	2010	In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression.	ursolic acid	65-77	plasminogen activator, urokinase	Homo sapiens	323-327
19908232-0	2010	Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid.	ursolic acid	89-101	nuclear factor kappa B subunit 1	Homo sapiens	73-82
19908232-2	2010	Ursolic acid, a minimally toxic compound, has shown the capability to inhibit NF-kappaB activation in living cells.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	78-87
19908232-3	2010	Here, for the first time, we investigated the effects and mechanisms of NF-kappaB inhibition by ursolic acid on chemotherapy treatment (Taxol or cisplatin) of cancer.	ursolic acid	96-108	nuclear factor kappa B subunit 1	Homo sapiens	72-81
19908232-6	2010	Ursolic acid-mediated suppression of NF-kappaB drastically reduced the required dosage of the chemotherapeutic agents to achieve identical biological endpoints and enhanced the chemotherapeutic agent-induced cancer cells apoptosis.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	37-46
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	caspase 8	Homo sapiens	115-124
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	BH3 interacting domain death agonist	Homo sapiens	125-128
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	cytochrome c, somatic	Homo sapiens	142-154
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	BH3 interacting domain death agonist	Homo sapiens	185-188
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	Fas ligand	Homo sapiens	220-224
19908232-7	2010	Chemosensitization by ursolic acid in cancer cells was dependent on the amplified activation of intrinsic pathway (caspase-8-BID-mitochondria-cytochrome c-caspase-3) by augmentation of BID cleavage and activation of Fas/FasL-caspase-8 pathway.	ursolic acid	22-34	caspase 8	Homo sapiens	225-234
19908232-8	2010	Prolonged treatment with relatively low doses of ursolic acid also sensitized cancer cells to the chemotherapeutic agents through suppression of NF-kappaB.	ursolic acid	49-61	nuclear factor kappa B subunit 1	Homo sapiens	145-154
19908232-10	2010	The inhibitive effect of ursolic acid on NF-kappaB was reversible, and the reversal was not accompanied by a loss in cells viability.	ursolic acid	25-37	nuclear factor kappa B subunit 1	Homo sapiens	41-50
20819578-0	2010	Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway.	ursolic acid	0-12	tumor protein p53	Homo sapiens	70-73
20819578-12	2010	Real-time RT-PCR confirmed UA could up-regulate the mRNA expressions of GDF15, SOD2, ATF3 and down-regulate the mRAN expression of fos.	ursolic acid	27-29	growth differentiation factor 15	Homo sapiens	72-77
20819578-12	2010	Real-time RT-PCR confirmed UA could up-regulate the mRNA expressions of GDF15, SOD2, ATF3 and down-regulate the mRAN expression of fos.	ursolic acid	27-29	superoxide dismutase 2	Homo sapiens	79-83
20819578-12	2010	Real-time RT-PCR confirmed UA could up-regulate the mRNA expressions of GDF15, SOD2, ATF3 and down-regulate the mRAN expression of fos.	ursolic acid	27-29	activating transcription factor 3	Homo sapiens	85-89
20819578-12	2010	Real-time RT-PCR confirmed UA could up-regulate the mRNA expressions of GDF15, SOD2, ATF3 and down-regulate the mRAN expression of fos.	ursolic acid	27-29	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-134
20599915-0	2010	Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naive T cells.	ursolic acid	0-12	toll like receptor 2	Homo sapiens	85-89
20599915-0	2010	Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naive T cells.	ursolic acid	0-12	toll like receptor 4	Homo sapiens	97-101
20599915-0	2010	Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naive T cells.	ursolic acid	0-12	interferon gamma	Homo sapiens	132-141
20599915-0	2010	Ursolic acid isolated from Uncaria rhynchophylla activates human dendritic cells via TLR2 and/or TLR4 and induces the production of IFN-gamma by CD4+ naive T cells.	ursolic acid	0-12	CD4 molecule	Homo sapiens	145-148
20599915-5	2010	The expression levels of CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on Ursolic acid-primed dendritic cells was slightly enhanced.	ursolic acid	68-80	CD1a molecule	Homo sapiens	25-29
20599915-5	2010	The expression levels of CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on Ursolic acid-primed dendritic cells was slightly enhanced.	ursolic acid	68-80	CD80 molecule	Homo sapiens	31-35
20599915-5	2010	The expression levels of CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on Ursolic acid-primed dendritic cells was slightly enhanced.	ursolic acid	68-80	CD83 molecule	Homo sapiens	37-41
20599915-5	2010	The expression levels of CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on Ursolic acid-primed dendritic cells was slightly enhanced.	ursolic acid	68-80	CD86 molecule	Homo sapiens	43-47
20599915-5	2010	The expression levels of CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on Ursolic acid-primed dendritic cells was slightly enhanced.	ursolic acid	68-80	C-C motif chemokine receptor 7	Homo sapiens	60-64
20599915-7	2010	The production of IL-12p70 induced by Ursolic acid-primed dendritic cells was inhibited by the anti-Toll-like receptor-2 (TLR2) mAb and anti-TLR4 mAb.	ursolic acid	38-50	toll like receptor 2	Homo sapiens	95-120
20599915-7	2010	The production of IL-12p70 induced by Ursolic acid-primed dendritic cells was inhibited by the anti-Toll-like receptor-2 (TLR2) mAb and anti-TLR4 mAb.	ursolic acid	38-50	toll like receptor 2	Homo sapiens	122-126
20599915-7	2010	The production of IL-12p70 induced by Ursolic acid-primed dendritic cells was inhibited by the anti-Toll-like receptor-2 (TLR2) mAb and anti-TLR4 mAb.	ursolic acid	38-50	toll like receptor 4	Homo sapiens	141-145
20599915-8	2010	Moreover, Ursolic acid-primed dendritic cells expressed levels of mRNA coding for both TLR2 and TLR4.	ursolic acid	10-22	toll like receptor 2	Homo sapiens	87-91
20599915-8	2010	Moreover, Ursolic acid-primed dendritic cells expressed levels of mRNA coding for both TLR2 and TLR4.	ursolic acid	10-22	toll like receptor 4	Homo sapiens	96-100
20599915-10	2010	Ursolic acid-primed dendritic cells have an intermediate migratory capacity towards CCL19 and CCL21.	ursolic acid	0-12	C-C motif chemokine ligand 19	Homo sapiens	84-89
20599915-10	2010	Ursolic acid-primed dendritic cells have an intermediate migratory capacity towards CCL19 and CCL21.	ursolic acid	0-12	C-C motif chemokine ligand 21	Homo sapiens	94-99
20599915-11	2010	These results suggest that Ursolic acid modulates human dendritic cells function in a fashion that favors Th1 polarization via the activation of IL-12p70 dependent on TLR2 and/or TLR4, and may be used on dendritic cells-based vaccines for cancer immunotherapy.	ursolic acid	27-39	toll like receptor 2	Homo sapiens	167-171
20599915-11	2010	These results suggest that Ursolic acid modulates human dendritic cells function in a fashion that favors Th1 polarization via the activation of IL-12p70 dependent on TLR2 and/or TLR4, and may be used on dendritic cells-based vaccines for cancer immunotherapy.	ursolic acid	27-39	toll like receptor 4	Homo sapiens	179-183
20462855-3	2010	The levels of serum vascular endothelial growth factor (VEGF), NO, and proinflammatory cytokines were significantly reduced in ursolic acid-treated animals compared with those in control animals.	ursolic acid	127-139	vascular endothelial growth factor A	Mus musculus	56-60
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	116-128	vascular endothelial growth factor A	Mus musculus	30-34
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	116-128	nitric oxide synthase 2, inducible	Mus musculus	39-43
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	116-128	tissue inhibitor of metalloproteinase 1	Mus musculus	167-173
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	116-128	tissue inhibitor of metalloproteinase 1	Mus musculus	175-214
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	116-128	interleukin 2	Mus musculus	220-224
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	116-128	interleukin 2	Mus musculus	226-239
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	286-298	vascular endothelial growth factor A	Mus musculus	30-34
20462855-4	2010	The diminished expressions of VEGF and iNOS genes in B16F-10 melanoma cells treated with nontoxic concentrations of ursolic acid support these observations; the serum TIMP-1 (tissue inhibitor of metalloproteinase-1) and IL-2 (interleukin-2) levels were significantly elevated after the ursolic acid treatment.	ursolic acid	286-298	nitric oxide synthase 2, inducible	Mus musculus	39-43
20462855-10	2010	Gelatin zymographic analysis showed the inhibitory effect of ursolic acid on the protein expression of matrix metalloproteinases MMP-2 and MMP-9.	ursolic acid	61-73	matrix metallopeptidase 2	Mus musculus	129-134
20462855-10	2010	Gelatin zymographic analysis showed the inhibitory effect of ursolic acid on the protein expression of matrix metalloproteinases MMP-2 and MMP-9.	ursolic acid	61-73	matrix metallopeptidase 9	Mus musculus	139-144
19846180-7	2010	The supplementation of ursolic acid significantly increased glucokinase activity, while decreasing glucose-6-phosphatase activity in the livers of STZ-induced diabetic mice.	ursolic acid	23-35	glucose-6-phosphatase, catalytic	Mus musculus	99-120
20415421-0	2010	Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.	ursolic acid	19-31	MIR7-3 host gene	Homo sapiens	52-56
20415421-0	2010	Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.	ursolic acid	19-31	X-linked inhibitor of apoptosis	Homo sapiens	158-162
20415421-2	2010	In the present study, the effects of OA and UA on induction of apoptosis in human hepatocellular carcinoma HuH7 cells and the related mechanisms were investigated.	ursolic acid	44-46	MIR7-3 host gene	Homo sapiens	107-111
20415421-4	2010	Cell cycle analysis using flow cytometry indicated that the fraction of HuH7 cells in sub-G1 phase progressively increased with increasing concentrations of OA or UA from 20 to 80 microM.	ursolic acid	163-165	MIR7-3 host gene	Homo sapiens	72-76
20415421-6	2010	OA and UA-induced apoptosis involving the release of mitochondria cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, followed by cleavage of poly (ADP-ribose) polymerase (PARP).	ursolic acid	7-9	cytochrome c, somatic	Homo sapiens	66-78
20415421-6	2010	OA and UA-induced apoptosis involving the release of mitochondria cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, followed by cleavage of poly (ADP-ribose) polymerase (PARP).	ursolic acid	7-9	caspase 9	Homo sapiens	139-148
20415421-6	2010	OA and UA-induced apoptosis involving the release of mitochondria cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, followed by cleavage of poly (ADP-ribose) polymerase (PARP).	ursolic acid	7-9	caspase 3	Homo sapiens	153-162
20415421-6	2010	OA and UA-induced apoptosis involving the release of mitochondria cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, followed by cleavage of poly (ADP-ribose) polymerase (PARP).	ursolic acid	7-9	poly(ADP-ribose) polymerase 1	Homo sapiens	188-216
20415421-6	2010	OA and UA-induced apoptosis involving the release of mitochondria cytochrome c into the cytosol and subsequently induced the activation of caspase-9 and caspase-3, followed by cleavage of poly (ADP-ribose) polymerase (PARP).	ursolic acid	7-9	poly(ADP-ribose) polymerase 1	Homo sapiens	218-222
20171069-2	2010	As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007; Awad et al., 2009).	ursolic acid	118-130	4-aminobutyrate aminotransferase	Mus musculus	146-182
20171069-2	2010	As measured by HPLC, Cyracos contains significant amounts of rosmarinic acid and the triterpenoids oleanolic acid and ursolic acid, which inhibit gamma-aminobutyric acid transaminase (GABA-T) activity and increase GABA levels in the brain (Awad et al., 2007; Awad et al., 2009).	ursolic acid	118-130	4-aminobutyrate aminotransferase	Mus musculus	184-190
20146252-0	2010	Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	59-62
20146252-0	2010	Ursolic acid induces PC-3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	81-84
20146252-4	2010	We found that UA treatment in vitro can effectively inhibit PC-3 cell viability in a dose-dependent manner by inducing apoptosis, demonstrated by annexin V-FITC/propidium iodide staining.	ursolic acid	14-16	annexin A5	Homo sapiens	146-155
20146252-5	2010	Both extrinsic and intrinsic apoptotic pathways appear to be triggered by UA treatment, because inhibiting activation of both caspase-8 and -9 could prevent UA-induced apoptosis in PC-3 cells.	ursolic acid	74-76	caspase 8	Homo sapiens	126-142
20146252-5	2010	Both extrinsic and intrinsic apoptotic pathways appear to be triggered by UA treatment, because inhibiting activation of both caspase-8 and -9 could prevent UA-induced apoptosis in PC-3 cells.	ursolic acid	157-159	caspase 8	Homo sapiens	126-142
20146252-7	2010	On the other hand, UA inhibited the Akt pathway, subsequently upregulating the expression of Fas ligand (FasL), which initiates death receptor-mediated apoptosis in PC-3 cells.	ursolic acid	19-21	AKT serine/threonine kinase 1	Homo sapiens	36-39
20146252-7	2010	On the other hand, UA inhibited the Akt pathway, subsequently upregulating the expression of Fas ligand (FasL), which initiates death receptor-mediated apoptosis in PC-3 cells.	ursolic acid	19-21	Fas ligand	Homo sapiens	93-103
20146252-7	2010	On the other hand, UA inhibited the Akt pathway, subsequently upregulating the expression of Fas ligand (FasL), which initiates death receptor-mediated apoptosis in PC-3 cells.	ursolic acid	19-21	Fas ligand	Homo sapiens	105-109
20146252-8	2010	Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA.	ursolic acid	86-88	Fas ligand	Homo sapiens	37-41
20146252-8	2010	Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA.	ursolic acid	86-88	caspase 8	Homo sapiens	97-106
20146252-8	2010	Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA.	ursolic acid	86-88	Fas ligand	Homo sapiens	204-208
20146252-8	2010	Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA.	ursolic acid	266-268	Fas ligand	Homo sapiens	37-41
20146252-8	2010	Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA.	ursolic acid	266-268	caspase 8	Homo sapiens	97-106
20146252-8	2010	Importantly, experimentally lowering FasL expression by siRNA significantly inhibited UA-induced caspase-8 activation and at least partly attenuated the consequent apoptosis, suggesting an involvement of FasL and its regulating pathway in the cell killing effect of UA.	ursolic acid	266-268	Fas ligand	Homo sapiens	204-208
20146252-9	2010	UA also inhibited cell invasion by downregulating matrix metalloproteinase-9 via inhibition of Akt in PC-3 cells.	ursolic acid	0-2	matrix metallopeptidase 9	Homo sapiens	50-76
20146252-9	2010	UA also inhibited cell invasion by downregulating matrix metalloproteinase-9 via inhibition of Akt in PC-3 cells.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	95-98
20005942-7	2010	Besides Huh7 cell, OA or UA treatments concentration-dependently elevated caspase-3 and caspase-8 activities in other three cell lines (P&lt;0.05).	ursolic acid	25-27	MIR7-3 host gene	Homo sapiens	8-12
20005942-7	2010	Besides Huh7 cell, OA or UA treatments concentration-dependently elevated caspase-3 and caspase-8 activities in other three cell lines (P&lt;0.05).	ursolic acid	25-27	caspase 3	Homo sapiens	74-83
20005942-7	2010	Besides Huh7 cell, OA or UA treatments concentration-dependently elevated caspase-3 and caspase-8 activities in other three cell lines (P&lt;0.05).	ursolic acid	25-27	caspase 8	Homo sapiens	88-97
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	ursolic acid	46-58	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	67-83
19944162-5	2010	The ATPase activities of P-glycoprotein were stimulated by carnosic acid, carnosol, and ursolic acid.	ursolic acid	88-100	dynein axonemal heavy chain 8	Homo sapiens	4-10
20052671-0	2010	Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	23-28
20052671-0	2010	Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	111-114
20052671-0	2010	Ursolic acid overcomes Bcl-2-mediated resistance to apoptosis in prostate cancer cells involving activation of JNK-induced Bcl-2 phosphorylation and degradation.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	123-128
20052671-5	2010	UA can overcome Bcl-2-mediated resistance to apoptosis in LNCaP-AI cells.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	16-21
20052671-6	2010	Intrinsic apoptotic pathways can be triggered by UA treatment because c-Jun N-terminal kinase (JNK) is activated and subsequently provokes Bcl-2 phosphorylation and degradation, inducing activation of caspase-9.	ursolic acid	49-51	mitogen-activated protein kinase 8	Homo sapiens	70-93
20052671-6	2010	Intrinsic apoptotic pathways can be triggered by UA treatment because c-Jun N-terminal kinase (JNK) is activated and subsequently provokes Bcl-2 phosphorylation and degradation, inducing activation of caspase-9.	ursolic acid	49-51	mitogen-activated protein kinase 8	Homo sapiens	95-98
20052671-6	2010	Intrinsic apoptotic pathways can be triggered by UA treatment because c-Jun N-terminal kinase (JNK) is activated and subsequently provokes Bcl-2 phosphorylation and degradation, inducing activation of caspase-9.	ursolic acid	49-51	BCL2 apoptosis regulator	Homo sapiens	139-144
20052671-6	2010	Intrinsic apoptotic pathways can be triggered by UA treatment because c-Jun N-terminal kinase (JNK) is activated and subsequently provokes Bcl-2 phosphorylation and degradation, inducing activation of caspase-9.	ursolic acid	49-51	caspase 9	Homo sapiens	201-210
20095565-9	2010	Both EEOA and ursolic acid inhibited LPS-stimulated protein and mRNA expression of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in these cells.	ursolic acid	14-26	nitric oxide synthase 2, inducible	Mus musculus	121-125
20095565-10	2010	These results demonstrate that EEOA and its bioactive compound, ursolic acid, suppress LPS-induced NO and PGE(2) production by inhibiting ROS generation, along with reducing expression of iNOS and COX-2 in RAW 264.7 cells.	ursolic acid	64-76	nitric oxide synthase 2, inducible	Mus musculus	188-192
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	ursolic acid	46-58	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	85-87
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	ursolic acid	60-62	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	67-83
19917277-1	2010	Inhibitory effects of oleanolic acid (OA) and ursolic acid (UA) on aldose reductase (AR) and glycative products in kidney of diabetic mice were examined.	ursolic acid	60-62	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	85-87
19917277-5	2010	OA or UA treatments at 0.1 and 0.2% also significantly diminished renal AR activity and dose-dependently down-regulated renal AR mRNA expression (P&lt;0.05).	ursolic acid	6-8	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	72-74
19917277-5	2010	OA or UA treatments at 0.1 and 0.2% also significantly diminished renal AR activity and dose-dependently down-regulated renal AR mRNA expression (P&lt;0.05).	ursolic acid	6-8	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	126-128
20137120-5	2010	Caspase-9, caspase-3 and cytochrome C were activated, and the phosphorylation of Akt was inhibited in the Jurkat cell apoptosis process induced by UA.	ursolic acid	147-149	caspase 9	Homo sapiens	0-9
20074555-0	2010	Evaluation of inhibition of fatty acid synthase by ursolic acid: positive cooperation mechanism.	ursolic acid	51-63	fatty acid synthase	Homo sapiens	28-47
20074555-1	2010	The inhibitory effect of ursolic acid (UA) on fatty acid synthase (FAS, EC 2.3.1.85) was investigated.	ursolic acid	25-37	fatty acid synthase	Homo sapiens	46-65
20074555-1	2010	The inhibitory effect of ursolic acid (UA) on fatty acid synthase (FAS, EC 2.3.1.85) was investigated.	ursolic acid	25-37	fatty acid synthase	Homo sapiens	67-70
20074555-1	2010	The inhibitory effect of ursolic acid (UA) on fatty acid synthase (FAS, EC 2.3.1.85) was investigated.	ursolic acid	39-41	fatty acid synthase	Homo sapiens	46-65
20074555-1	2010	The inhibitory effect of ursolic acid (UA) on fatty acid synthase (FAS, EC 2.3.1.85) was investigated.	ursolic acid	39-41	fatty acid synthase	Homo sapiens	67-70
20074555-2	2010	We found that UA potently inhibited the activity of FAS with a half-inhibitory concentration value (IC(50)) of 6.0 microg/ml.	ursolic acid	14-16	fatty acid synthase	Homo sapiens	52-55
20074555-3	2010	The inhibition kinetic results showed that the inhibition of FAS by UA was competitive against acetyl-CoA and malonyl-CoA, but uncompetitive to NADPH.	ursolic acid	68-70	fatty acid synthase	Homo sapiens	61-64
20074555-4	2010	UA at low concentration slowly inactivated FAS, but FAS was fast inactivated by high concentration of UA in a positive cooperative manner.	ursolic acid	0-2	fatty acid synthase	Homo sapiens	43-46
20074555-4	2010	UA at low concentration slowly inactivated FAS, but FAS was fast inactivated by high concentration of UA in a positive cooperative manner.	ursolic acid	102-104	fatty acid synthase	Homo sapiens	52-55
20074555-5	2010	Moreover, NADPH significantly enhanced the inactivation of FAS by low concentration of UA, but NADPH slightly decreased the inactivation of FAS by high concentration of UA.	ursolic acid	87-89	fatty acid synthase	Homo sapiens	59-62
20074555-5	2010	Moreover, NADPH significantly enhanced the inactivation of FAS by low concentration of UA, but NADPH slightly decreased the inactivation of FAS by high concentration of UA.	ursolic acid	169-171	fatty acid synthase	Homo sapiens	140-143
20074555-6	2010	Taken together, the results suggest that ursolic acid decreases the FAS activity through inactivation of acetyl/malonyl transferase.	ursolic acid	41-53	fatty acid synthase	Homo sapiens	68-71
20074555-7	2010	The combination of NADPH and KR domain promotes the inhibitory effect of UA on FAS.	ursolic acid	73-75	fatty acid synthase	Homo sapiens	79-82
20137120-5	2010	Caspase-9, caspase-3 and cytochrome C were activated, and the phosphorylation of Akt was inhibited in the Jurkat cell apoptosis process induced by UA.	ursolic acid	147-149	caspase 3	Homo sapiens	11-20
20137120-5	2010	Caspase-9, caspase-3 and cytochrome C were activated, and the phosphorylation of Akt was inhibited in the Jurkat cell apoptosis process induced by UA.	ursolic acid	147-149	cytochrome c, somatic	Homo sapiens	25-37
20137120-5	2010	Caspase-9, caspase-3 and cytochrome C were activated, and the phosphorylation of Akt was inhibited in the Jurkat cell apoptosis process induced by UA.	ursolic acid	147-149	AKT serine/threonine kinase 1	Homo sapiens	81-84
19911773-2	2010	This work revealed that betulinic (1), oleanolic (2), and ursolic acid (3) exhibited TGR5 agonist activity in a selective manner compared to bile acids, which also activated FXR, the nuclear bile acid receptor.	ursolic acid	58-70	G protein-coupled bile acid receptor 1	Homo sapiens	85-89
19911773-2	2010	This work revealed that betulinic (1), oleanolic (2), and ursolic acid (3) exhibited TGR5 agonist activity in a selective manner compared to bile acids, which also activated FXR, the nuclear bile acid receptor.	ursolic acid	58-70	nuclear receptor subfamily 1 group H member 4	Homo sapiens	174-177
21058195-5	2010	All UA doses decreased tumor cell proliferation, as assessed by Ki67 immunostaining; nevertheless, UA at 0.10% was most effective in inhibiting tumor take and decreasing tumor final tumor size.	ursolic acid	4-6	antigen identified by monoclonal antibody Ki 67	Mus musculus	64-68
19440893-0	2009	Ursolic acid triggers apoptosis and Bcl-2 downregulation in MCF-7 breast cancer cells.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	36-41
19545597-0	2009	Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis.	ursolic acid	96-108	BCL2 apoptosis regulator	Homo sapiens	19-24
19545597-0	2009	Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis.	ursolic acid	96-108	caspase 3	Homo sapiens	43-52
19545597-0	2009	Phosphorylation of Bcl-2 and activation of caspase-3 via the c-Jun N-terminal kinase pathway in ursolic acid-induced DU145 cells apoptosis.	ursolic acid	96-108	mitogen-activated protein kinase 8	Homo sapiens	61-84
19545597-4	2009	We demonstrated that UA induces apoptosis and the activation of caspase-3 in DU145 cells.	ursolic acid	21-23	caspase 3	Homo sapiens	64-73
19545597-5	2009	UA also causes the activation of c-Jun N-terminal kinase (JNK), but has no effect on extracellular signal-regulated protein kinases (ERK1/2) and p38 MAP kinases (p38).	ursolic acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	33-56
19545597-5	2009	UA also causes the activation of c-Jun N-terminal kinase (JNK), but has no effect on extracellular signal-regulated protein kinases (ERK1/2) and p38 MAP kinases (p38).	ursolic acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	58-61
19545597-6	2009	UA-induced JNK activation could result in Bcl-2 phosphorylation (Ser70) and degradation in DU145 cells, which may be one of the molecular mechanisms by which it induces apoptosis.	ursolic acid	0-2	mitogen-activated protein kinase 8	Homo sapiens	11-14
19545597-6	2009	UA-induced JNK activation could result in Bcl-2 phosphorylation (Ser70) and degradation in DU145 cells, which may be one of the molecular mechanisms by which it induces apoptosis.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	42-47
19735099-0	2009	Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway.	ursolic acid	0-12	epidermal growth factor receptor	Homo sapiens	104-108
19735099-0	2009	Ursolic acid inhibits proliferation and induces apoptosis of HT-29 colon cancer cells by inhibiting the EGFR/MAPK pathway.	ursolic acid	0-12	mitogen-activated protein kinase 3	Homo sapiens	109-113
19735099-3	2009	Western blot analysis was applied to investigate the inhibitory effects of ursolic acid on the phosphorylation of the epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), and the activity of B cell leukemia-2 (Bcl-2), B cell leukemia-xL (Bcl-xL), caspase-3, and caspase-9.	ursolic acid	75-87	epidermal growth factor receptor	Homo sapiens	118-150
19735099-3	2009	Western blot analysis was applied to investigate the inhibitory effects of ursolic acid on the phosphorylation of the epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), and the activity of B cell leukemia-2 (Bcl-2), B cell leukemia-xL (Bcl-xL), caspase-3, and caspase-9.	ursolic acid	75-87	epidermal growth factor receptor	Homo sapiens	152-156
19735099-3	2009	Western blot analysis was applied to investigate the inhibitory effects of ursolic acid on the phosphorylation of the epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), and the activity of B cell leukemia-2 (Bcl-2), B cell leukemia-xL (Bcl-xL), caspase-3, and caspase-9.	ursolic acid	75-87	mitogen-activated protein kinase 1	Homo sapiens	159-196
19735099-3	2009	Western blot analysis was applied to investigate the inhibitory effects of ursolic acid on the phosphorylation of the epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK), and the activity of B cell leukemia-2 (Bcl-2), B cell leukemia-xL (Bcl-xL), caspase-3, and caspase-9.	ursolic acid	75-87	mitogen-activated protein kinase 8	Homo sapiens	204-227
19735099-7	2009	Ursolic acid suppressed the phosphorylation of EGFR, ERK1/2, p38 MAPK, and JNK, which is well correlated with its growth inhibitory effect.	ursolic acid	0-12	epidermal growth factor receptor	Homo sapiens	47-51
19735099-7	2009	Ursolic acid suppressed the phosphorylation of EGFR, ERK1/2, p38 MAPK, and JNK, which is well correlated with its growth inhibitory effect.	ursolic acid	0-12	mitogen-activated protein kinase 3	Homo sapiens	53-59
19735099-7	2009	Ursolic acid suppressed the phosphorylation of EGFR, ERK1/2, p38 MAPK, and JNK, which is well correlated with its growth inhibitory effect.	ursolic acid	0-12	mitogen-activated protein kinase 14	Homo sapiens	61-69
19735099-7	2009	Ursolic acid suppressed the phosphorylation of EGFR, ERK1/2, p38 MAPK, and JNK, which is well correlated with its growth inhibitory effect.	ursolic acid	0-12	mitogen-activated protein kinase 8	Homo sapiens	75-78
19735099-11	2009	CONCLUSION: Ursolic acid induces apoptosis in HT-29 cells by suppressing the EGFR/MAPK pathway, suggesting that it may be a potent agent for the treatment of colorectal cancer.	ursolic acid	12-24	epidermal growth factor receptor	Homo sapiens	77-81
19735099-11	2009	CONCLUSION: Ursolic acid induces apoptosis in HT-29 cells by suppressing the EGFR/MAPK pathway, suggesting that it may be a potent agent for the treatment of colorectal cancer.	ursolic acid	12-24	mitogen-activated protein kinase 3	Homo sapiens	82-86
19344998-0	2009	Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.	ursolic acid	24-36	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	119-123
20037823-7	2009	The intracellular ERK activity and p-ERK1/2 expression were also reduced in the UA-treated cells, while the MKP-1 expression was elevated.	ursolic acid	80-82	mitogen-activated protein kinase 1	Homo sapiens	18-21
20037823-7	2009	The intracellular ERK activity and p-ERK1/2 expression were also reduced in the UA-treated cells, while the MKP-1 expression was elevated.	ursolic acid	80-82	mitogen-activated protein kinase 3	Homo sapiens	37-43
20037823-7	2009	The intracellular ERK activity and p-ERK1/2 expression were also reduced in the UA-treated cells, while the MKP-1 expression was elevated.	ursolic acid	80-82	dual specificity phosphatase 1	Homo sapiens	108-113
20037823-8	2009	Moreover, the apoptosis was found in the CAOV3 cells exposed to UA; the Bax expression was increased and the Bcl-2 expression decreased.	ursolic acid	64-66	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
20037823-8	2009	Moreover, the apoptosis was found in the CAOV3 cells exposed to UA; the Bax expression was increased and the Bcl-2 expression decreased.	ursolic acid	64-66	BCL2 apoptosis regulator	Homo sapiens	109-114
20037823-10	2009	It is concluded that UA can inhibit the proliferation of CAOV3 cells by suppressing the ERK activity and the expression of p-ERK1/2.	ursolic acid	21-23	mitogen-activated protein kinase 1	Homo sapiens	88-91
20037823-10	2009	It is concluded that UA can inhibit the proliferation of CAOV3 cells by suppressing the ERK activity and the expression of p-ERK1/2.	ursolic acid	21-23	mitogen-activated protein kinase 3	Homo sapiens	125-131
19344998-0	2009	Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.	ursolic acid	24-36	KRAS proto-oncogene, GTPase	Homo sapiens	110-114
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	43-55	nuclear receptor subfamily 3 group C member 1	Homo sapiens	97-120
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	43-55	nuclear receptor subfamily 3 group C member 1	Homo sapiens	122-124
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	43-55	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-149
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	43-55	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	151-155
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	57-59	nuclear receptor subfamily 3 group C member 1	Homo sapiens	97-120
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	57-59	nuclear receptor subfamily 3 group C member 1	Homo sapiens	122-124
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	57-59	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-149
19440893-1	2009	In this report we determine the ability of ursolic acid (UA) to induce apoptosis and to modulate glucocorticoid receptor (GR) and Activator Protein-1 (AP-1) in MCF-7 cells.	ursolic acid	57-59	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	151-155
19440893-2	2009	The UA-induced apoptosis (53 microM), the PARP cleavage, and the decrease in Bcl-2 protein (53 microM) support the notion that UA induces apoptosis through the intrinsic mitochondrial pathway.	ursolic acid	127-129	collagen type XI alpha 2 chain	Homo sapiens	42-46
19440893-2	2009	The UA-induced apoptosis (53 microM), the PARP cleavage, and the decrease in Bcl-2 protein (53 microM) support the notion that UA induces apoptosis through the intrinsic mitochondrial pathway.	ursolic acid	127-129	BCL2 apoptosis regulator	Homo sapiens	77-82
19440893-3	2009	UA binds GR (relative binding affinity: 2.57) and translocates GR into nucleus, suggesting its potential as a GR modulator.	ursolic acid	0-2	nuclear receptor subfamily 3 group C member 1	Homo sapiens	9-11
19440893-3	2009	UA binds GR (relative binding affinity: 2.57) and translocates GR into nucleus, suggesting its potential as a GR modulator.	ursolic acid	0-2	nuclear receptor subfamily 3 group C member 1	Homo sapiens	63-65
19440893-3	2009	UA binds GR (relative binding affinity: 2.57) and translocates GR into nucleus, suggesting its potential as a GR modulator.	ursolic acid	0-2	nuclear receptor subfamily 3 group C member 1	Homo sapiens	63-65
19655411-5	2009	In addition, pre-treatment with ursolic acid significantly attenuated the decrease of activities of catalase (CAT) and glutathione peroxidase (GPX), but superoxide dismutase (SOD) activity was not significantly affected by ursolic acid.	ursolic acid	32-44	catalase	Homo sapiens	110-113
19534471-3	2009	Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.	ursolic acid	59-71	histone deacetylase 9	Homo sapiens	188-192
19329757-7	2009	Statistically significant effects on activities of caspase-3 and -7 were observed only after GSE and URA treatments.	ursolic acid	101-104	caspase 3	Mus musculus	51-67
18973186-0	2009	Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.	ursolic acid	0-12	interleukin 1 beta	Rattus norvegicus	22-30
18973186-0	2009	Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.	ursolic acid	0-12	tumor necrosis factor	Rattus norvegicus	34-43
18973186-0	2009	Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.	ursolic acid	0-12	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	111-114
18973186-0	2009	Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.	ursolic acid	0-12	protein kinase C, zeta	Rattus norvegicus	120-128
18973186-0	2009	Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.	ursolic acid	0-12	matrix metallopeptidase 9	Rattus norvegicus	152-157
18973186-2	2009	In the present study, we found that UA was able to reduce interleukin-1 beta (IL-1beta) or tumor necrosis-alpha (TNF-alpha)-induced rat C6 glioma cell invasion, which was examined by a reconstituted basement membrane in a set of transwell chambers.	ursolic acid	36-38	interleukin 1 beta	Rattus norvegicus	58-76
18973186-2	2009	In the present study, we found that UA was able to reduce interleukin-1 beta (IL-1beta) or tumor necrosis-alpha (TNF-alpha)-induced rat C6 glioma cell invasion, which was examined by a reconstituted basement membrane in a set of transwell chambers.	ursolic acid	36-38	interleukin 1 beta	Rattus norvegicus	78-86
18973186-2	2009	In the present study, we found that UA was able to reduce interleukin-1 beta (IL-1beta) or tumor necrosis-alpha (TNF-alpha)-induced rat C6 glioma cell invasion, which was examined by a reconstituted basement membrane in a set of transwell chambers.	ursolic acid	36-38	tumor necrosis factor	Rattus norvegicus	113-122
18973186-4	2009	The results analyzed by zymography assay and Western blotting revealed that the activity and expression of matrix metalloproteinase-9 (MMP-9) was eliminated by UA in a dose-dependent manner.	ursolic acid	160-162	matrix metallopeptidase 9	Rattus norvegicus	107-133
18973186-4	2009	The results analyzed by zymography assay and Western blotting revealed that the activity and expression of matrix metalloproteinase-9 (MMP-9) was eliminated by UA in a dose-dependent manner.	ursolic acid	160-162	matrix metallopeptidase 9	Rattus norvegicus	135-140
18973186-8	2009	Our data showed UA potently inhibited the association of ZIP/p62 and PKC-zeta.	ursolic acid	16-18	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	61-64
18973186-8	2009	Our data showed UA potently inhibited the association of ZIP/p62 and PKC-zeta.	ursolic acid	16-18	protein kinase C, zeta	Rattus norvegicus	69-77
18973186-9	2009	Taken together, we demonstrated that UA could efficiently inhibit the interaction of ZIP/p62 and PKC-zeta.	ursolic acid	37-39	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	89-92
18973186-9	2009	Taken together, we demonstrated that UA could efficiently inhibit the interaction of ZIP/p62 and PKC-zeta.	ursolic acid	37-39	protein kinase C, zeta	Rattus norvegicus	97-105
19174695-0	2009	Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis.	ursolic acid	87-99	caspase 3	Homo sapiens	45-54
19174695-0	2009	Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis.	ursolic acid	87-99	AKT serine/threonine kinase 1	Homo sapiens	72-75
19174695-5	2009	UA-induced apoptosis was accompanied by a significant decrease in bcl-2 and survivin expression, with the corresponding ratio of bax/bcl-2 increased.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	66-71
19174695-5	2009	UA-induced apoptosis was accompanied by a significant decrease in bcl-2 and survivin expression, with the corresponding ratio of bax/bcl-2 increased.	ursolic acid	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
19174695-5	2009	UA-induced apoptosis was accompanied by a significant decrease in bcl-2 and survivin expression, with the corresponding ratio of bax/bcl-2 increased.	ursolic acid	0-2	BCL2 apoptosis regulator	Homo sapiens	133-138
19174695-6	2009	The treatment with UA also increased the protein level and enzymatic activity of caspase-3.	ursolic acid	19-21	caspase 3	Homo sapiens	81-90
19174695-7	2009	Z-DEVD-fmk, a specific caspase-3 inhibitor, significantly inhibited both the cytotoxic effect and the DNA fragmentation induced by UA, demonstrating the requirement for caspase-3 activity in UA-induced apoptosis.	ursolic acid	131-133	caspase 3	Homo sapiens	23-32
19174695-7	2009	Z-DEVD-fmk, a specific caspase-3 inhibitor, significantly inhibited both the cytotoxic effect and the DNA fragmentation induced by UA, demonstrating the requirement for caspase-3 activity in UA-induced apoptosis.	ursolic acid	131-133	caspase 3	Homo sapiens	169-178
19174695-7	2009	Z-DEVD-fmk, a specific caspase-3 inhibitor, significantly inhibited both the cytotoxic effect and the DNA fragmentation induced by UA, demonstrating the requirement for caspase-3 activity in UA-induced apoptosis.	ursolic acid	191-193	caspase 3	Homo sapiens	23-32
19174695-7	2009	Z-DEVD-fmk, a specific caspase-3 inhibitor, significantly inhibited both the cytotoxic effect and the DNA fragmentation induced by UA, demonstrating the requirement for caspase-3 activity in UA-induced apoptosis.	ursolic acid	191-193	caspase 3	Homo sapiens	169-178
19174695-8	2009	Inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway was also involved, as inhibition of PI3K by LY294002 significantly increased UA-induced apoptosis.	ursolic acid	156-158	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	20-49
19174695-8	2009	Inactivation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway was also involved, as inhibition of PI3K by LY294002 significantly increased UA-induced apoptosis.	ursolic acid	156-158	AKT serine/threonine kinase 1	Homo sapiens	57-60
19174695-9	2009	Kinetic experiments indicated that UA downregulated PI3K/p85 subunit (PI3K/p85) and phospho-Akt, before downregulating survivin.	ursolic acid	35-37	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	57-60
19174695-9	2009	Kinetic experiments indicated that UA downregulated PI3K/p85 subunit (PI3K/p85) and phospho-Akt, before downregulating survivin.	ursolic acid	35-37	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	75-78
19174695-9	2009	Kinetic experiments indicated that UA downregulated PI3K/p85 subunit (PI3K/p85) and phospho-Akt, before downregulating survivin.	ursolic acid	35-37	AKT serine/threonine kinase 1	Homo sapiens	92-95
19174695-11	2009	UA therefore seemed to downregulate the expression of survivin by blocking PI3K/Akt.	ursolic acid	0-2	AKT serine/threonine kinase 1	Homo sapiens	80-83
19174695-12	2009	Taken together, the data suggest that the proapoptotic effect of UA on HepG2 cells is mediated by activation of caspase-3, and is highly correlated with inactivation of PI3K/Akt/survivin pathway.	ursolic acid	65-67	caspase 3	Homo sapiens	112-121
19174695-12	2009	Taken together, the data suggest that the proapoptotic effect of UA on HepG2 cells is mediated by activation of caspase-3, and is highly correlated with inactivation of PI3K/Akt/survivin pathway.	ursolic acid	65-67	AKT serine/threonine kinase 1	Homo sapiens	174-177
19655411-6	2009	These results indicate that ursolic acid protects hydrogen peroxide-induced HEI-OC1 cell damage through inhibition of lipid peroxidation and induction of antioxidant enzymes, CAT and GPX, and may be one of the active components responsible for these effects of C. officinalis fruits.	ursolic acid	28-40	catalase	Homo sapiens	175-178
19013541-8	2009	Ursolic acid enhanced IL-2 and IFN-gamma production in response to Con A stimulation, whereas it inhibited TNF-alpha production in response to LPS stimulation.	ursolic acid	0-12	interleukin 2	Mus musculus	22-26
19013541-8	2009	Ursolic acid enhanced IL-2 and IFN-gamma production in response to Con A stimulation, whereas it inhibited TNF-alpha production in response to LPS stimulation.	ursolic acid	0-12	interferon gamma	Mus musculus	31-40
19013541-8	2009	Ursolic acid enhanced IL-2 and IFN-gamma production in response to Con A stimulation, whereas it inhibited TNF-alpha production in response to LPS stimulation.	ursolic acid	0-12	tumor necrosis factor	Mus musculus	107-116
18822379-5	2008	Noggin also inhibited the activation of Smad and the induction of BMP-2 mRNA expression by ursolic acid in the late stage of osteoblast differentiation.	ursolic acid	91-103	bone morphogenetic protein 2	Mus musculus	66-71
18822379-7	2008	A high proportion of positive immunostaining of BMP-2 was found in the nuclear region of woven bone formed by ursolic acid.	ursolic acid	110-122	bone morphogenetic protein 2	Mus musculus	48-53
18822379-3	2008	We found that ursolic acid induced the expression of osteoblast-specific genes with the activation of mitogen-activated protein kinases, nuclear factor-kappaB, and activator protein-1.	ursolic acid	14-26	jun proto-oncogene	Mus musculus	102-183
18822379-4	2008	Additionally, noggin, an antagonist of bone morphogenetic proteins (BMPs), inhibited ursolic acid-induced osteoblast differentiation.	ursolic acid	85-97	noggin	Mus musculus	14-20
18812028-7	2008	Moreover, UA significantly suppressed the arthritis-induced mechanical and thermal hyperalgesia as well as the spinal Fos expression, as determined by immunohistochemistry, which was increased by CFA injection.	ursolic acid	10-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	118-121
18822379-5	2008	Noggin also inhibited the activation of Smad and the induction of BMP-2 mRNA expression by ursolic acid in the late stage of osteoblast differentiation.	ursolic acid	91-103	noggin	Mus musculus	0-6
18486908-0	2008	Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells.	ursolic acid	0-12	transformation related protein 53, pseudogene	Mus musculus	45-48
18538348-0	2008	Strain differences regarding susceptibility to ursolic acid-induced interleukin-1beta release in murine macrophages.	ursolic acid	47-59	interleukin 1 beta	Mus musculus	68-85
18538348-2	2008	We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice.	ursolic acid	39-51	interleukin 1 beta	Mus musculus	209-217
18538348-2	2008	We have recently found that aggregated ursolic acid (UA), a triterpene carboxylic acid, is recognized by CD36 for generating reactive oxygen species (ROS) via NADPH oxidase (NOX) activation, thereby releasing IL-1beta protein from murine peritoneal macrophages (pMphi) in female ICR mice.	ursolic acid	53-55	interleukin 1 beta	Mus musculus	209-217
18538348-3	2008	In the present study, we investigated the ability of UA for inducing IL-1beta production in pMphi from 4 different strains of female mice (C57BL/6J, C3H/He, DDY, and ICR), as well as an established macrophage line (RAW264.7 cells).	ursolic acid	53-55	interleukin 1 beta	Mus musculus	69-77
18538348-4	2008	The levels of IL-1beta released from UA-treated pMphi of C57BL/6J and DDY mice were significantly lower than from those of ICR mice, whereas IL-1beta was not released from the pMphi of C3H/He mice or RAW264.7 cells.	ursolic acid	37-39	interleukin 1 beta	Mus musculus	14-22
18538348-6	2008	In addition, the different susceptibilities to UA-induced IL-1beta release were suggested to be correlated with the amount of superoxide anion (O2-) generated from the 5 different types of Mphi.	ursolic acid	47-49	interleukin 1 beta	Mus musculus	58-66
18538348-8	2008	Together, our results indicate that the UA-induced IL-1beta release was strain-dependent, and the expression status of CD36 and gp91phox is strongly associated with inducibility.	ursolic acid	40-42	interleukin 1 beta	Mus musculus	51-59
18538348-8	2008	Together, our results indicate that the UA-induced IL-1beta release was strain-dependent, and the expression status of CD36 and gp91phox is strongly associated with inducibility.	ursolic acid	40-42	cytochrome b-245, beta polypeptide	Mus musculus	128-136
18448068-2	2008	Treatment with ursolic acid increased the expression of adhesion molecules such as E-selectin, CD-31 and I-CAM, upregulated angiogenic growth factors such as VEGF and FGF-2 and their receptors and caused increase in the ratio of PGE(2) to PGD(2).	ursolic acid	15-27	selectin E	Homo sapiens	83-93
18448068-2	2008	Treatment with ursolic acid increased the expression of adhesion molecules such as E-selectin, CD-31 and I-CAM, upregulated angiogenic growth factors such as VEGF and FGF-2 and their receptors and caused increase in the ratio of PGE(2) to PGD(2).	ursolic acid	15-27	platelet and endothelial cell adhesion molecule 1	Homo sapiens	95-100
18448068-2	2008	Treatment with ursolic acid increased the expression of adhesion molecules such as E-selectin, CD-31 and I-CAM, upregulated angiogenic growth factors such as VEGF and FGF-2 and their receptors and caused increase in the ratio of PGE(2) to PGD(2).	ursolic acid	15-27	vascular endothelial growth factor A	Homo sapiens	158-162
18448068-2	2008	Treatment with ursolic acid increased the expression of adhesion molecules such as E-selectin, CD-31 and I-CAM, upregulated angiogenic growth factors such as VEGF and FGF-2 and their receptors and caused increase in the ratio of PGE(2) to PGD(2).	ursolic acid	15-27	fibroblast growth factor 2	Homo sapiens	167-172
18448068-3	2008	Reversal of the effect of ursolic acid by inhibition of PI3K-Akt pathway and increase in the level of phospho Akt suggest that the ursolic acid effect is mediated through PI3K-Akt pathway.	ursolic acid	26-38	AKT serine/threonine kinase 1	Homo sapiens	61-64
18448068-3	2008	Reversal of the effect of ursolic acid by inhibition of PI3K-Akt pathway and increase in the level of phospho Akt suggest that the ursolic acid effect is mediated through PI3K-Akt pathway.	ursolic acid	131-143	AKT serine/threonine kinase 1	Homo sapiens	110-113
18448068-3	2008	Reversal of the effect of ursolic acid by inhibition of PI3K-Akt pathway and increase in the level of phospho Akt suggest that the ursolic acid effect is mediated through PI3K-Akt pathway.	ursolic acid	131-143	AKT serine/threonine kinase 1	Homo sapiens	110-113
18486908-0	2008	Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells.	ursolic acid	0-12	caspase 3	Mus musculus	53-62
18486908-0	2008	Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells.	ursolic acid	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
18486908-0	2008	Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-kappaB mediated activation of bcl-2 in B16F-10 melanoma cells.	ursolic acid	0-12	B cell leukemia/lymphoma 2	Mus musculus	129-134
18486908-3	2008	The apoptotic genes p53 and caspase-3 were found to be upregulated while the anti-apoptotic gene bcl-2 was down regulated in ursolic acid treated cells.	ursolic acid	125-137	transformation related protein 53, pseudogene	Mus musculus	20-23
18486908-3	2008	The apoptotic genes p53 and caspase-3 were found to be upregulated while the anti-apoptotic gene bcl-2 was down regulated in ursolic acid treated cells.	ursolic acid	125-137	caspase 3	Mus musculus	28-37
18486908-3	2008	The apoptotic genes p53 and caspase-3 were found to be upregulated while the anti-apoptotic gene bcl-2 was down regulated in ursolic acid treated cells.	ursolic acid	125-137	B cell leukemia/lymphoma 2	Mus musculus	97-102
18486908-5	2008	The pro-inflammatory cytokine production and gene expression of TNF-alpha, IL-1beta, IL-6 and GM-CSF were down regulated in ursolic acid treated cells compared to nontreated B16F-10 metastatic melanoma cells.	ursolic acid	124-136	tumor necrosis factor	Mus musculus	64-73
18486908-5	2008	The pro-inflammatory cytokine production and gene expression of TNF-alpha, IL-1beta, IL-6 and GM-CSF were down regulated in ursolic acid treated cells compared to nontreated B16F-10 metastatic melanoma cells.	ursolic acid	124-136	interleukin 1 beta	Mus musculus	75-83
18486908-5	2008	The pro-inflammatory cytokine production and gene expression of TNF-alpha, IL-1beta, IL-6 and GM-CSF were down regulated in ursolic acid treated cells compared to nontreated B16F-10 metastatic melanoma cells.	ursolic acid	124-136	interleukin 6	Mus musculus	85-89
18486908-5	2008	The pro-inflammatory cytokine production and gene expression of TNF-alpha, IL-1beta, IL-6 and GM-CSF were down regulated in ursolic acid treated cells compared to nontreated B16F-10 metastatic melanoma cells.	ursolic acid	124-136	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-100
18486908-6	2008	All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways.	ursolic acid	35-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
18486908-6	2008	All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways.	ursolic acid	35-47	B cell leukemia/lymphoma 2	Mus musculus	101-106
18486908-6	2008	All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways.	ursolic acid	35-47	transformation related protein 53, pseudogene	Mus musculus	168-171
18486908-6	2008	All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways.	ursolic acid	35-47	tumor necrosis factor	Mus musculus	185-194
18486908-6	2008	All these results demonstrate that ursolic acid induce apoptosis via inhibition of NF-kappaB induced bcl-2 mediated anti-apoptotic pathway and subsequent activation of p53 mediated and TNF-alpha induced caspase-3 mediated pro-apoptotic pathways.	ursolic acid	35-47	caspase 3	Mus musculus	203-212
18569082-10	2008	The elevated level of GM-CSF in tumor-alone treated control animals (37.9 +/- 1.1 pg/ml) was reduced by the treatment with glycyrrhizic acid (20.3 pg/ml) and ursolic acid (22.5 pg/ml).	ursolic acid	158-170	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	22-28
19051345-6	2008	Analysis of the anti-inflammatory effects of ursolic acid and oleanolic acid, the triterpene compounds present in PPY, showed that ursolic acid significantly inhibited LPS-induced IL-8 production, NF-kappaB activation, and iNOS mRNA expression, whereas oleanolic acid did not have these effects.	ursolic acid	131-143	C-X-C motif chemokine ligand 8	Homo sapiens	180-184
19051345-6	2008	Analysis of the anti-inflammatory effects of ursolic acid and oleanolic acid, the triterpene compounds present in PPY, showed that ursolic acid significantly inhibited LPS-induced IL-8 production, NF-kappaB activation, and iNOS mRNA expression, whereas oleanolic acid did not have these effects.	ursolic acid	131-143	nitric oxide synthase 2	Homo sapiens	223-227
18423155-1	2008	OBJECTIVE: To investigate the effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells (HSC) in vitro and explore the mechanisms of apoptosis of HSC induced by ursolic acid by studying the expressions of apoptosis-regulating proteins Bcl-2, Bax and Caspase 3 in HSC.	ursolic acid	183-195	BCL2, apoptosis regulator	Rattus norvegicus	257-262
18423155-1	2008	OBJECTIVE: To investigate the effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells (HSC) in vitro and explore the mechanisms of apoptosis of HSC induced by ursolic acid by studying the expressions of apoptosis-regulating proteins Bcl-2, Bax and Caspase 3 in HSC.	ursolic acid	183-195	BCL2 associated X, apoptosis regulator	Rattus norvegicus	264-267
18423155-1	2008	OBJECTIVE: To investigate the effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells (HSC) in vitro and explore the mechanisms of apoptosis of HSC induced by ursolic acid by studying the expressions of apoptosis-regulating proteins Bcl-2, Bax and Caspase 3 in HSC.	ursolic acid	183-195	caspase 3	Rattus norvegicus	272-281
18423155-13	2008	Our results suggest that HSC-T6 cell apoptosis induced by ursolic acid occurs through mechanisms involving mitochondrial pathways and Bcl-2 family proteins.	ursolic acid	58-70	BCL2, apoptosis regulator	Rattus norvegicus	134-139
18569082-11	2008	The highly elevated level of IL-6 (370.1 pg/ml) in control animals was also reduced by the treatment of glycyrrhizic acid (313 pg/ml) and ursolic acid (299 pg/ml).	ursolic acid	138-150	interleukin 6	Mus musculus	29-33
18569082-12	2008	The level of IL-2 was enhanced by the treatment with glycyrrhizic acid (37.9 pg/ml) and ursolic acid (35.9) compared to untreated tumor-bearing control animals (24.9 pg/ml).	ursolic acid	88-100	interleukin 2	Mus musculus	13-17
17481637-0	2007	Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells.	ursolic acid	0-12	NADPH oxidase 4	Homo sapiens	103-107
18097588-5	2008	In both cell lines, UA induced significant caspase-3 activation, the downstream central effector of apoptosis.	ursolic acid	20-22	caspase 3	Homo sapiens	43-52
18097588-7	2008	This was confirmed by Western blot analysis, which revealed a Bax/Bcl-2-balance change in favor of Bax, the proapoptotic member, in UA-treated M4Beu cells.	ursolic acid	132-134	BCL2 associated X, apoptosis regulator	Homo sapiens	62-65
18097588-7	2008	This was confirmed by Western blot analysis, which revealed a Bax/Bcl-2-balance change in favor of Bax, the proapoptotic member, in UA-treated M4Beu cells.	ursolic acid	132-134	BCL2 apoptosis regulator	Homo sapiens	66-71
18097588-7	2008	This was confirmed by Western blot analysis, which revealed a Bax/Bcl-2-balance change in favor of Bax, the proapoptotic member, in UA-treated M4Beu cells.	ursolic acid	132-134	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
17605045-3	2008	Earlier studies showed that UA has anti-proliferative and apoptotic effects on HT29 cells, accompanied by a rapid increase in alkaline sphingomyelinase (Alk-SMase) activity.	ursolic acid	28-30	ectonucleotide pyrophosphatase/phosphodiesterase 7	Homo sapiens	126-151
17605045-3	2008	Earlier studies showed that UA has anti-proliferative and apoptotic effects on HT29 cells, accompanied by a rapid increase in alkaline sphingomyelinase (Alk-SMase) activity.	ursolic acid	28-30	ectonucleotide pyrophosphatase/phosphodiesterase 7	Homo sapiens	153-162
17481637-7	2007	Interestingly, ursolic acid also reduced the expression of the NADPH oxidase subunit Nox4 and suppressed the production of reactive oxygen species in human endothelial cells.	ursolic acid	15-27	NADPH oxidase 4	Homo sapiens	85-89
17692828-7	2007	And UA also inhibited the activation of caspase-3 induced by D-gal.	ursolic acid	4-6	caspase 3	Mus musculus	40-49
17692828-8	2007	Furthermore, we found that UA significantly increased the level of growth-associated protein GAP43 in the brain of D-gal-treated mice.	ursolic acid	27-29	growth associated protein 43	Mus musculus	93-98
17727365-0	2007	Simultaneous effect of ursolic acid and oleanolic acid on epidermal permeability barrier function and epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor-alpha.	ursolic acid	23-35	peroxisome proliferator activated receptor alpha	Homo sapiens	145-193
17727365-5	2007	Finally, we observed that UA and ONA stimulated epidermal keratinocyte differentiation via peroxisome proliferator-activated receptor (PPAR)-alpha using Western immunoblotting.	ursolic acid	26-28	peroxisome proliferator activated receptor alpha	Homo sapiens	91-146
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	ursolic acid	168-170	peroxisome proliferator activated receptor alpha	Homo sapiens	22-32
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	ursolic acid	168-170	involucrin	Homo sapiens	34-44
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	ursolic acid	168-170	loricrin cornified envelope precursor protein	Homo sapiens	46-54
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	ursolic acid	168-170	peroxisome proliferator activated receptor alpha	Homo sapiens	337-347
17727365-10	2007	Protein expression of PPAR-alpha, involucrin, loricrin and filaggrin increased twofold and threefold in HaCaT cells treated for 24 h with either ONA (10 micromol/L) or UA (10 micromol/L), respectively, reflecting that the UA and ONA can improve the recovery of skin barrier function and induce epidermal keratinocyte differentiation via PPAR-alpha.	ursolic acid	222-224	peroxisome proliferator activated receptor alpha	Homo sapiens	22-32
17855663-0	2007	Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.	ursolic acid	0-12	signal transducer and activator of transcription 3	Homo sapiens	22-27
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	signal transducer and activator of transcription 3	Homo sapiens	46-51
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	cyclin D1	Homo sapiens	84-93
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	95-100
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	BCL2 like 1	Homo sapiens	102-108
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	120-125
17855663-9	2007	Ursolic acid down-regulated the expression of STAT3-regulated gene products such as cyclin D1, Bcl-2, Bcl-xL, survivin, Mcl-1, and vascular endothelial growth factor.	ursolic acid	0-12	vascular endothelial growth factor A	Homo sapiens	131-165
17855663-12	2007	Overall, these results suggest that ursolic acid is a novel blocker of STAT3 activation that may have a potential in prevention and treatment of multiple myeloma and other cancers.	ursolic acid	36-48	signal transducer and activator of transcription 3	Homo sapiens	71-76
17855663-3	2007	In the present report, we tested an agent, ursolic acid, found in basil, apples, prunes, and cranberries, for its ability to suppress STAT3 activation.	ursolic acid	43-55	signal transducer and activator of transcription 3	Homo sapiens	134-139
17855663-4	2007	We found that ursolic acid, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in multiple myeloma cells.	ursolic acid	14-26	interleukin 6	Homo sapiens	88-101
17855663-4	2007	We found that ursolic acid, a pentacyclic triterpenoid, inhibited both constitutive and interleukin-6-inducible STAT3 activation in a dose- and time-dependent manner in multiple myeloma cells.	ursolic acid	14-26	signal transducer and activator of transcription 3	Homo sapiens	112-117
17855663-6	2007	Vanadate treatment reversed the ursolic acid-induced down-regulation of STAT3, suggesting the involvement of a tyrosine phosphatase.	ursolic acid	32-44	signal transducer and activator of transcription 3	Homo sapiens	72-77
17855663-7	2007	Indeed, we found that ursolic acid induced the expression of tyrosine phosphatase SHP-1 protein and mRNA.	ursolic acid	22-34	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	82-87
17516089-4	2007	METHODS: The ursolic acid-induced changes in cell viability, apoptosis and bcl-2 protein were examined in human hormone refractory prostate cancer PC-3 cells and androgen-sensitive LNCaP cells, by MTT assay, flow cytometry and western blot analysis, respectively.	ursolic acid	13-25	chromobox 8	Homo sapiens	147-151
17516089-3	2007	Our main objective was to investigate the effects of ursolic acid on cell viability, apoptosis and bcl-2 protein, in human hormone refractory and androgen-sensitive prostate cancer cells.	ursolic acid	53-65	BCL2 apoptosis regulator	Homo sapiens	99-104
17764066-0	2007	Induction of apoptosis and regulation of the MAPK pathway by ursolic acid in human leukemia K562 cells.	ursolic acid	61-73	mitogen-activated protein kinase 3	Homo sapiens	45-49
17764066-3	2007	Here, we report that treatment with UA induces apoptosis in human leukemia K562 cells and down-regulates protein levels of bcl-xL.	ursolic acid	36-38	BCL2 like 1	Homo sapiens	123-129
17764066-5	2007	These results suggest that JNK may participate in UA-induced apoptosis in K562 cells.	ursolic acid	50-52	mitogen-activated protein kinase 8	Homo sapiens	27-30
17516089-4	2007	METHODS: The ursolic acid-induced changes in cell viability, apoptosis and bcl-2 protein were examined in human hormone refractory prostate cancer PC-3 cells and androgen-sensitive LNCaP cells, by MTT assay, flow cytometry and western blot analysis, respectively.	ursolic acid	13-25	BCL2 apoptosis regulator	Homo sapiens	75-80
17516089-5	2007	RESULTS: Ursolic acid inhibited significantly the cell viability and induced apoptosis in PC-3 cells at 55 microM and in LNCaP cells at 45 microM associated with a downregulation of bcl-2 protein.	ursolic acid	9-21	chromobox 8	Homo sapiens	90-94
17516089-5	2007	RESULTS: Ursolic acid inhibited significantly the cell viability and induced apoptosis in PC-3 cells at 55 microM and in LNCaP cells at 45 microM associated with a downregulation of bcl-2 protein.	ursolic acid	9-21	BCL2 apoptosis regulator	Homo sapiens	182-187
17516089-6	2007	CONCLUSIONS: The antiproliferative and apoptotic effects of ursolic acid in PC-3 and LNCaP cells implicate its potential therapeutic use for the treatment of hormone refractory and androgen-sensitive prostate cancer.	ursolic acid	60-72	chromobox 8	Homo sapiens	76-80
17404266-0	2007	Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36.	ursolic acid	11-23	interleukin 1 beta	Mus musculus	57-65
17404266-2	2007	We recently found that a natural triterpene, ursolic acid (UA), enhanced MIF release from nonstimulated macrophages.	ursolic acid	45-57	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	73-76
17404266-2	2007	We recently found that a natural triterpene, ursolic acid (UA), enhanced MIF release from nonstimulated macrophages.	ursolic acid	59-61	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	73-76
17404266-4	2007	UA increased the protein release of IL-1beta, IL-6, and MIF, but not of TNF-alpha, in dose- and time-dependent manners.	ursolic acid	0-2	interleukin 1 beta	Mus musculus	36-44
17404266-4	2007	UA increased the protein release of IL-1beta, IL-6, and MIF, but not of TNF-alpha, in dose- and time-dependent manners.	ursolic acid	0-2	interleukin 6	Mus musculus	46-50
17404266-4	2007	UA increased the protein release of IL-1beta, IL-6, and MIF, but not of TNF-alpha, in dose- and time-dependent manners.	ursolic acid	0-2	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	56-59
17404266-6	2007	The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1.	ursolic acid	15-17	interleukin 1 beta	Mus musculus	26-34
17404266-6	2007	The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1.	ursolic acid	15-17	mitogen-activated protein kinase 14	Mus musculus	84-92
17404266-6	2007	The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1.	ursolic acid	15-17	mitogen-activated protein kinase kinase 1	Mus musculus	94-100
17404266-6	2007	The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1.	ursolic acid	15-17	ATP-binding cassette, sub-family A (ABC1), member 13	Mus musculus	102-134
17404266-6	2007	The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1.	ursolic acid	15-17	caspase 1	Mus musculus	140-149
17404266-7	2007	Furthermore, UA induced intracellular ROS generation for IL-1beta production, which was suppressed by an antioxidant.	ursolic acid	13-15	interleukin 1 beta	Mus musculus	57-65
17404266-8	2007	Pretreatment with an anti-CD36 Ab significantly suppressed IL-1beta release, and surface plasmon resonance assay results showed that UA bound to CD36 on macrophages.	ursolic acid	133-135	interleukin 1 beta	Mus musculus	59-67
17404266-9	2007	In addition, the amount of IL-1beta released from UA-treated pMphi of CD36-deficient mice was markedly lower than that from those of wild-type mice.	ursolic acid	50-52	interleukin 1 beta	Mus musculus	27-35
17404266-10	2007	Interestingly, UA was found to aggregate in culture medium, and the aggregates were suggested to be responsible for IL-1beta production.	ursolic acid	15-17	interleukin 1 beta	Mus musculus	116-124
17404266-12	2007	administration of UA increased the levels of IL-1beta secretion and MPO activity in colonic mucosa of ICR mice.	ursolic acid	18-20	interleukin 1 beta	Mus musculus	45-53
17404266-12	2007	administration of UA increased the levels of IL-1beta secretion and MPO activity in colonic mucosa of ICR mice.	ursolic acid	18-20	myeloperoxidase	Mus musculus	68-71
17404266-13	2007	Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter.	ursolic acid	53-55	mitogen-activated protein kinase 14	Mus musculus	142-150
17404266-13	2007	Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter.	ursolic acid	53-55	mitogen-activated protein kinase 3	Mus musculus	152-158
17404266-13	2007	Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter.	ursolic acid	53-55	caspase 1	Mus musculus	164-173
17404266-13	2007	Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter.	ursolic acid	53-55	interleukin 1 beta	Mus musculus	196-204
17404266-13	2007	Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter.	ursolic acid	53-55	ATP-binding cassette, sub-family A (ABC1), member 13	Mus musculus	221-253
17352226-2	2007	In this study, there was a significant increase in the gene expression of matrix metalloproteinase (MMP)-1, -2 -3, -9 and -10 in H460 cells after treatment with 10 microM ursolic acid for 24 h. Under these experimental conditions, it was found that ursolic acid induced H460 cell apoptosis.	ursolic acid	171-183	matrix metallopeptidase 1	Homo sapiens	74-125
17352226-2	2007	In this study, there was a significant increase in the gene expression of matrix metalloproteinase (MMP)-1, -2 -3, -9 and -10 in H460 cells after treatment with 10 microM ursolic acid for 24 h. Under these experimental conditions, it was found that ursolic acid induced H460 cell apoptosis.	ursolic acid	249-261	matrix metallopeptidase 1	Homo sapiens	74-125
17352226-4	2007	It has been suggested that ursolic acid acts via a glucocorticoid receptor in the regulation of MMP.	ursolic acid	27-39	nuclear receptor subfamily 3 group C member 1	Homo sapiens	51-74
17352226-4	2007	It has been suggested that ursolic acid acts via a glucocorticoid receptor in the regulation of MMP.	ursolic acid	27-39	matrix metallopeptidase 1	Homo sapiens	96-99
17352226-5	2007	Our study also demonstrated that the localization of glucocorticoid receptor in the cytosol might be an important factor of MMP up-regulation during ursolic acid-induced H460 cell apoptosis.	ursolic acid	149-161	nuclear receptor subfamily 3 group C member 1	Homo sapiens	53-76
17352226-5	2007	Our study also demonstrated that the localization of glucocorticoid receptor in the cytosol might be an important factor of MMP up-regulation during ursolic acid-induced H460 cell apoptosis.	ursolic acid	149-161	matrix metallopeptidase 1	Homo sapiens	124-127
17352226-6	2007	Ursolic acid induced a typical apoptosis on H460 cells, which was characterized by the activation of caspase-3, nuclear morphological changes and DNA fragmentation.	ursolic acid	0-12	caspase 3	Homo sapiens	101-110
17165581-0	2006	[Determination of ursolic acid of Liuwei Dihuangwan simulation samples by NIR].	ursolic acid	18-30	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	74-77
17213663-0	2007	Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells.	ursolic acid	105-117	AKT serine/threonine kinase 1	Homo sapiens	48-51
17213663-8	2007	This effect was most pronounced following treatment with 50 mum ursolic acid for 72 h. Our study found inhibition of both the PI3K-Akt pathway and the MAPK pathway in two endometrial cancer cell lines, SNG-II and the poorly differentiated HEC108 cell line.	ursolic acid	64-76	AKT serine/threonine kinase 1	Homo sapiens	131-134
16828971-0	2006	Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.	ursolic acid	0-12	insulin receptor	Cricetulus griseus	83-99
16828971-4	2006	As competitive inhibitors of PTP1B, ursolic acid and its derivative also inhibit T-cell protein tyrosine phosphatase and src homology phosphatase-2 but not leucocyte antigen-related phosphatase or protein tyrosine phosphatase alpha and epsilon, which are all possibly involved in the insulin pathway.	ursolic acid	36-48	proto-oncogene tyrosine-protein kinase Src	Cricetulus griseus	121-124
16828971-5	2006	The ursolic acid derivative enhanced insulin receptor phosphorylation in CHO/hIR cells and stimulate glucose uptake in L6 myotubes.	ursolic acid	4-16	insulin receptor	Cricetulus griseus	37-53
17456043-0	2007	Group IIA secretory PLA2 inhibition by ursolic acid: a potent anti-inflammatory molecule.	ursolic acid	39-51	phospholipase A2 group IIA	Homo sapiens	20-24
17456043-3	2007	Ursolic acid inhibited secretory PLA2 (sPLA2) enzymes purified from Vipera russelli, Naja naja venom and human pleural fluid and synovial fluid.	ursolic acid	0-12	phospholipase A2 group IIA	Homo sapiens	33-37
17456043-3	2007	Ursolic acid inhibited secretory PLA2 (sPLA2) enzymes purified from Vipera russelli, Naja naja venom and human pleural fluid and synovial fluid.	ursolic acid	0-12	phospholipase A2 group IIA	Homo sapiens	39-44
17456043-7	2007	Similarly sPLA2 inhibition by ursolic acid is independent of substrate concentration.	ursolic acid	30-42	phospholipase A2 group IIA	Homo sapiens	10-15
17456043-8	2007	Ursolic acid interacts with purified venom sPLA2 enzymes and enhances relative fluorescence intensity in a dose dependent manner.	ursolic acid	0-12	phospholipase A2 group IIA	Homo sapiens	43-48
17456043-9	2007	In the presence of ursolic acid apparent shift in the far UV-CD spectra of sPLA2 was observed, indicating a direct interaction with the enzyme and formation of enzyme-ursolic acid complex.	ursolic acid	19-31	phospholipase A2 group IIA	Homo sapiens	75-80
17456043-9	2007	In the presence of ursolic acid apparent shift in the far UV-CD spectra of sPLA2 was observed, indicating a direct interaction with the enzyme and formation of enzyme-ursolic acid complex.	ursolic acid	167-179	phospholipase A2 group IIA	Homo sapiens	75-80
17456043-12	2007	These studies revealed that the strong anti-inflammatory activity of ursolic acid is by inhibiting sPLA2 enzymes.	ursolic acid	69-81	phospholipase A2 group IIA	Homo sapiens	99-104
17177841-8	2006	The expression of Fas protein was induced, and caspase-8, caspase-3, and poly ADP-ribose polymerase (PARP) proteins were cleaved after ursolic acid treatment.	ursolic acid	135-147	caspase 8	Homo sapiens	47-56
17177841-8	2006	The expression of Fas protein was induced, and caspase-8, caspase-3, and poly ADP-ribose polymerase (PARP) proteins were cleaved after ursolic acid treatment.	ursolic acid	135-147	caspase 3	Homo sapiens	58-67
17177841-8	2006	The expression of Fas protein was induced, and caspase-8, caspase-3, and poly ADP-ribose polymerase (PARP) proteins were cleaved after ursolic acid treatment.	ursolic acid	135-147	poly(ADP-ribose) polymerase 1	Homo sapiens	73-99
17177841-8	2006	The expression of Fas protein was induced, and caspase-8, caspase-3, and poly ADP-ribose polymerase (PARP) proteins were cleaved after ursolic acid treatment.	ursolic acid	135-147	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105
17165581-4	2006	CONCLUSION: NIR can be used in the determination of ursolic acid, which set up the foundation of on-line control of traditional Chinese medicine.	ursolic acid	52-64	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	12-15
16406805-0	2006	Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production.	ursolic acid	46-58	negative elongation factor complex member C/D, Th1l	Mus musculus	75-78
16630635-13	2006	These results indicate that UA-mediated relaxation is endothelium dependent, probably due to NO release, and the consequent activation of vascular smooth muscle soluble guanylate cyclase (sGC), a signal transduction enzyme that forms the second messenger cGMP.	ursolic acid	28-30	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	188-191
16613675-3	2006	This study was to investigate the effect of UA on COX-2, Bcl-2 and Bax expression in human gastric cancer cell line SGC7901, and explore its potential mechanisms of inhibiting proliferation and inducing apoptosis.	ursolic acid	44-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	50-55
16613675-3	2006	This study was to investigate the effect of UA on COX-2, Bcl-2 and Bax expression in human gastric cancer cell line SGC7901, and explore its potential mechanisms of inhibiting proliferation and inducing apoptosis.	ursolic acid	44-46	BCL2 apoptosis regulator	Homo sapiens	57-62
16613675-3	2006	This study was to investigate the effect of UA on COX-2, Bcl-2 and Bax expression in human gastric cancer cell line SGC7901, and explore its potential mechanisms of inhibiting proliferation and inducing apoptosis.	ursolic acid	44-46	BCL2 associated X, apoptosis regulator	Homo sapiens	67-70
16613675-9	2006	When treated with 20-40 micromol/L UA for 24 h, SGC7901 cells were arrested at G0/G1 phase, and the apoptosis rates were (9.10+/-2.39)%, (26.30+/-1.25)%, and (35.20+/-2.26)%, respectively; meanwhile, COX-2 expression and its catalysate PGE2 were decreased, Bcl-2 expression was also decreased, whereas Bax expression was unchanged.	ursolic acid	35-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	200-205
16613675-9	2006	When treated with 20-40 micromol/L UA for 24 h, SGC7901 cells were arrested at G0/G1 phase, and the apoptosis rates were (9.10+/-2.39)%, (26.30+/-1.25)%, and (35.20+/-2.26)%, respectively; meanwhile, COX-2 expression and its catalysate PGE2 were decreased, Bcl-2 expression was also decreased, whereas Bax expression was unchanged.	ursolic acid	35-37	BCL2 apoptosis regulator	Homo sapiens	257-262
16613675-9	2006	When treated with 20-40 micromol/L UA for 24 h, SGC7901 cells were arrested at G0/G1 phase, and the apoptosis rates were (9.10+/-2.39)%, (26.30+/-1.25)%, and (35.20+/-2.26)%, respectively; meanwhile, COX-2 expression and its catalysate PGE2 were decreased, Bcl-2 expression was also decreased, whereas Bax expression was unchanged.	ursolic acid	35-37	BCL2 associated X, apoptosis regulator	Homo sapiens	302-305
16613675-10	2006	CONCLUSION: UA could inhibit proliferation and induce apoptosis of SGC7901 cells through arresting cell cycle, inhibiting COX-2 expression to reduce PGE2 production and down-regulate Bcl-2 expression.	ursolic acid	12-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-127
16613675-10	2006	CONCLUSION: UA could inhibit proliferation and induce apoptosis of SGC7901 cells through arresting cell cycle, inhibiting COX-2 expression to reduce PGE2 production and down-regulate Bcl-2 expression.	ursolic acid	12-14	BCL2 apoptosis regulator	Homo sapiens	183-188
16636478-0	2006	Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin.	ursolic acid	0-12	tumor necrosis factor	Mus musculus	42-69
16636478-2	2006	In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-alpha, whereas its effect on tumor promotion was unclear.	ursolic acid	53-55	cytochrome c oxidase I, mitochondrial	Mus musculus	137-159
16636478-2	2006	In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-alpha, whereas its effect on tumor promotion was unclear.	ursolic acid	53-55	cytochrome c oxidase II, mitochondrial	Mus musculus	161-166
16636478-2	2006	In this study, we found that topical applications of UA to mouse skin twice a week for 2 weeks significantly enhanced mRNA expression of cyclooxygenase (COX)-1, COX-2, and tumor necrosis factor-alpha, whereas its effect on tumor promotion was unclear.	ursolic acid	53-55	tumor necrosis factor	Mus musculus	172-199
16596994-2	2006	The present study showed that dietary antioxidants such as (-)-epigallocatechin gallate, quercerin, rutin, resveratrol, and ursolic acid inhibit single strand breaks in supercoiled plasmid DNA induced by 3-morpholinosydnomine N-ethylcarbamide (SIN-1), a generator of peroxynitrite through the reaction between nitric oxide and superoxide anion.	ursolic acid	124-136	MAPK associated protein 1	Homo sapiens	244-249
16406805-0	2006	Amelioration of adjuvant-induced arthritis by ursolic acid through altered Th1/Th2 cytokine production.	ursolic acid	46-58	heart and neural crest derivatives expressed 2	Mus musculus	79-82
16406805-1	2006	The objective of the study was to investigate the activity of ursolic acid (UA) on proinflammatory (Th1) and anti-inflammatory (Th2) cytokines in the peripheral blood of arthritic balb/c mice.	ursolic acid	62-74	negative elongation factor complex member C/D, Th1l	Mus musculus	100-103
16406805-1	2006	The objective of the study was to investigate the activity of ursolic acid (UA) on proinflammatory (Th1) and anti-inflammatory (Th2) cytokines in the peripheral blood of arthritic balb/c mice.	ursolic acid	62-74	heart and neural crest derivatives expressed 2	Mus musculus	128-131
16406805-1	2006	The objective of the study was to investigate the activity of ursolic acid (UA) on proinflammatory (Th1) and anti-inflammatory (Th2) cytokines in the peripheral blood of arthritic balb/c mice.	ursolic acid	76-78	negative elongation factor complex member C/D, Th1l	Mus musculus	100-103
16406805-1	2006	The objective of the study was to investigate the activity of ursolic acid (UA) on proinflammatory (Th1) and anti-inflammatory (Th2) cytokines in the peripheral blood of arthritic balb/c mice.	ursolic acid	76-78	heart and neural crest derivatives expressed 2	Mus musculus	128-131
16406805-7	2006	Oral administration of UA at doses of 10, 20, 40, 80 and 160 mg kg(-1) per oral dose inhibited the presence of IL-2, IFN-gamma and TNF-alpha in the peripheral blood.	ursolic acid	23-25	interleukin 2	Mus musculus	111-115
16406805-7	2006	Oral administration of UA at doses of 10, 20, 40, 80 and 160 mg kg(-1) per oral dose inhibited the presence of IL-2, IFN-gamma and TNF-alpha in the peripheral blood.	ursolic acid	23-25	interferon gamma	Mus musculus	117-126
16406805-7	2006	Oral administration of UA at doses of 10, 20, 40, 80 and 160 mg kg(-1) per oral dose inhibited the presence of IL-2, IFN-gamma and TNF-alpha in the peripheral blood.	ursolic acid	23-25	tumor necrosis factor	Mus musculus	131-140
16521214-7	2006	Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA.	ursolic acid	161-163	prostaglandin-endoperoxide synthase 2	Homo sapiens	36-41
16521214-7	2006	Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA.	ursolic acid	161-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	71-89
16521214-7	2006	Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA.	ursolic acid	161-163	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-34
16521214-7	2006	Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA.	ursolic acid	161-163	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	91-94
16570804-0	2006	[Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells].	ursolic acid	11-23	caspase 3	Homo sapiens	27-36
15922347-4	2006	The exposure of VSMC to ursolic acid results in a chemotaxis inhibition, in a reduction of the expression of proliferating cell nuclear antigen (PCNA) and in a disorganization of beta-tubulin and vimentin cytoskeletal proteins.	ursolic acid	24-36	proliferating cell nuclear antigen	Rattus norvegicus	109-143
15922347-4	2006	The exposure of VSMC to ursolic acid results in a chemotaxis inhibition, in a reduction of the expression of proliferating cell nuclear antigen (PCNA) and in a disorganization of beta-tubulin and vimentin cytoskeletal proteins.	ursolic acid	24-36	proliferating cell nuclear antigen	Rattus norvegicus	145-149
16364033-0	2006	Phytocomponents of triterpenoids, oleanolic acid and ursolic acid, regulated differently the processing of epidermal keratinocytes via PPAR-alpha pathway.	ursolic acid	53-65	peroxisome proliferator activated receptor alpha	Homo sapiens	135-145
16570804-0	2006	[Effect of ursolic acid on caspase-3 and PARP expression of human MCF-7 cells].	ursolic acid	11-23	poly(ADP-ribose) polymerase 1	Homo sapiens	41-45
16570804-1	2006	OBJECTIVE: To study the effect of ursolic acid (UA), apentacyclic triterpene acid, on MCF-7 cell apoptosis, and probable mechanism involved by detecting the expressions of caspase-3 and poly ADP-ribose polymerase(PARP) at protein level.	ursolic acid	34-46	caspase 3	Homo sapiens	172-181
16570804-1	2006	OBJECTIVE: To study the effect of ursolic acid (UA), apentacyclic triterpene acid, on MCF-7 cell apoptosis, and probable mechanism involved by detecting the expressions of caspase-3 and poly ADP-ribose polymerase(PARP) at protein level.	ursolic acid	34-46	poly(ADP-ribose) polymerase 1	Homo sapiens	186-212
16570804-1	2006	OBJECTIVE: To study the effect of ursolic acid (UA), apentacyclic triterpene acid, on MCF-7 cell apoptosis, and probable mechanism involved by detecting the expressions of caspase-3 and poly ADP-ribose polymerase(PARP) at protein level.	ursolic acid	34-46	poly(ADP-ribose) polymerase 1	Homo sapiens	213-217
16570804-1	2006	OBJECTIVE: To study the effect of ursolic acid (UA), apentacyclic triterpene acid, on MCF-7 cell apoptosis, and probable mechanism involved by detecting the expressions of caspase-3 and poly ADP-ribose polymerase(PARP) at protein level.	ursolic acid	48-50	caspase 3	Homo sapiens	172-181
16570804-1	2006	OBJECTIVE: To study the effect of ursolic acid (UA), apentacyclic triterpene acid, on MCF-7 cell apoptosis, and probable mechanism involved by detecting the expressions of caspase-3 and poly ADP-ribose polymerase(PARP) at protein level.	ursolic acid	48-50	poly(ADP-ribose) polymerase 1	Homo sapiens	186-212
16570804-1	2006	OBJECTIVE: To study the effect of ursolic acid (UA), apentacyclic triterpene acid, on MCF-7 cell apoptosis, and probable mechanism involved by detecting the expressions of caspase-3 and poly ADP-ribose polymerase(PARP) at protein level.	ursolic acid	48-50	poly(ADP-ribose) polymerase 1	Homo sapiens	213-217
16570804-13	2006	CONCLUSION: The results suggest that UA evokes MCF-7 cell apoptosis is correlation with the up-regulation of caspase-3.	ursolic acid	37-39	caspase 3	Homo sapiens	109-118
16103078-6	2005	Similar results were obtained with U0126 and ursolic acid, specific and nonspecific inhibitors of ERK1/2, respectively.	ursolic acid	45-57	mitogen-activated protein kinase 3	Homo sapiens	98-104
16188240-0	2005	Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.	ursolic acid	0-12	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	37-75
16188240-0	2005	Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.	ursolic acid	0-12	mitogen-activated protein kinase 1	Mus musculus	80-84
16188240-3	2005	We investigated the effects of UA on MIF protein release in resting RAW264.7 mouse Mvarphi, and found that it decreased intracellular MIF protein levels and promoted the release of MIF into the culture media in dose- and time-dependent manners, without affecting mRNA levels.	ursolic acid	31-33	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	37-40
16188240-3	2005	We investigated the effects of UA on MIF protein release in resting RAW264.7 mouse Mvarphi, and found that it decreased intracellular MIF protein levels and promoted the release of MIF into the culture media in dose- and time-dependent manners, without affecting mRNA levels.	ursolic acid	31-33	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	134-137
16188240-3	2005	We investigated the effects of UA on MIF protein release in resting RAW264.7 mouse Mvarphi, and found that it decreased intracellular MIF protein levels and promoted the release of MIF into the culture media in dose- and time-dependent manners, without affecting mRNA levels.	ursolic acid	31-33	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	134-137
16188240-5	2005	In addition, UA-promoted MIF release was significantly inhibited by PD98059, a MEK1/2 inhibitor, while siRNA for ERK2, but not ERK1, significantly decreased the amount of MIF protein released.	ursolic acid	13-15	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	25-28
16188240-5	2005	In addition, UA-promoted MIF release was significantly inhibited by PD98059, a MEK1/2 inhibitor, while siRNA for ERK2, but not ERK1, significantly decreased the amount of MIF protein released.	ursolic acid	13-15	mitogen-activated protein kinase kinase 1	Mus musculus	79-85
16188240-5	2005	In addition, UA-promoted MIF release was significantly inhibited by PD98059, a MEK1/2 inhibitor, while siRNA for ERK2, but not ERK1, significantly decreased the amount of MIF protein released.	ursolic acid	13-15	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	171-174
16188240-6	2005	These results suggest that UA triggers the release of intracellular MIF protein through the ERK2 activation.	ursolic acid	27-29	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	68-71
16188240-6	2005	These results suggest that UA triggers the release of intracellular MIF protein through the ERK2 activation.	ursolic acid	27-29	mitogen-activated protein kinase 1	Mus musculus	92-96
16188235-6	2005	In addition, Western blot analysis showed Cyt c and AIF transferred from mitochondrial pellet to the supernatant after the addition of 50 microM Ca2+, but the process was significantly inhibited by various concentrations of UA.	ursolic acid	224-226	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	52-55
16309197-5	2005	Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, Bcl-2 and Bcl-xL, although the pro-apoptotic proteins, Bax and Bak, remained unaffected.	ursolic acid	74-86	caspase 8	Homo sapiens	125-134
16309197-5	2005	Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, Bcl-2 and Bcl-xL, although the pro-apoptotic proteins, Bax and Bak, remained unaffected.	ursolic acid	74-86	BCL2 apoptosis regulator	Homo sapiens	183-188
16309197-5	2005	Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, Bcl-2 and Bcl-xL, although the pro-apoptotic proteins, Bax and Bak, remained unaffected.	ursolic acid	74-86	BCL2 like 1	Homo sapiens	193-199
16309197-5	2005	Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, Bcl-2 and Bcl-xL, although the pro-apoptotic proteins, Bax and Bak, remained unaffected.	ursolic acid	74-86	BCL2 associated X, apoptosis regulator	Homo sapiens	238-241
16309197-5	2005	Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase-8 and a reduction in the anti-apoptotic proteins, Bcl-2 and Bcl-xL, although the pro-apoptotic proteins, Bax and Bak, remained unaffected.	ursolic acid	74-86	BCL2 antagonist/killer 1	Homo sapiens	246-249
15649620-8	2005	These results demonstrate that UA induces hepatic MT expression through TNF-alpha and IL-6 released from UA-activated macrophages, which may be the mechanism, whereby UA elicits its biological effects.	ursolic acid	31-33	tumor necrosis factor	Mus musculus	72-81
15922841-2	2005	Structural modifications were performed on the C-3, C-28 and C-11 positions of ursolic acid and the cytotoxicity of the derivatives was evaluated.	ursolic acid	79-91	RNA polymerase III subunit K	Homo sapiens	61-65
16104504-12	2005	UA increased p 53 protein expression.	ursolic acid	0-2	tumor protein p53	Homo sapiens	13-17
16104504-13	2005	CONCLUSION: The results suggest that UA evokes MCF-7 cell apoptosis is correlation with the up-regulation of p 53.	ursolic acid	37-39	tumor protein p53	Homo sapiens	109-113
16012738-4	2005	Investigation of caspase activity in ursolic acid-treated HEC108 cells showed that exposure at 50, 75 or 100 microM induced marked increases in caspase-3 activity (after 24 h) to 5.00, 11.76 or 12.75 times that of control levels, while cleaved caspase-3 levels increased in dose-dependent manner after 24 h. Activation of caspase was shown to lead to the cleavage of target proteins such as PARP.	ursolic acid	37-49	caspase 3	Homo sapiens	144-153
16012738-4	2005	Investigation of caspase activity in ursolic acid-treated HEC108 cells showed that exposure at 50, 75 or 100 microM induced marked increases in caspase-3 activity (after 24 h) to 5.00, 11.76 or 12.75 times that of control levels, while cleaved caspase-3 levels increased in dose-dependent manner after 24 h. Activation of caspase was shown to lead to the cleavage of target proteins such as PARP.	ursolic acid	37-49	caspase 3	Homo sapiens	244-253
16012738-4	2005	Investigation of caspase activity in ursolic acid-treated HEC108 cells showed that exposure at 50, 75 or 100 microM induced marked increases in caspase-3 activity (after 24 h) to 5.00, 11.76 or 12.75 times that of control levels, while cleaved caspase-3 levels increased in dose-dependent manner after 24 h. Activation of caspase was shown to lead to the cleavage of target proteins such as PARP.	ursolic acid	37-49	poly(ADP-ribose) polymerase 1	Homo sapiens	391-395
16012738-5	2005	Ursolic acid treatment also resulted in a cleavage of poly(ADP-ribose) polymerase in a dose-dependent manner.	ursolic acid	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	54-81
16012738-6	2005	Testing whether caspase-3 activation and DNA polymerase activity were inhibited by the addition of Ac-DEDV-HOC during ursolic acid treatment showed that 50 microM Ac-DEDV-HOC inhibited caspase-3 activity in treated cells.	ursolic acid	118-130	caspase 3	Homo sapiens	16-25
16012738-6	2005	Testing whether caspase-3 activation and DNA polymerase activity were inhibited by the addition of Ac-DEDV-HOC during ursolic acid treatment showed that 50 microM Ac-DEDV-HOC inhibited caspase-3 activity in treated cells.	ursolic acid	118-130	caspase 3	Homo sapiens	185-194
16012738-7	2005	A mitochondrial pathway has been suggested to be involved in ursolic acid-induced apoptosis because the treatment induces mitochondria cytochrome c release.	ursolic acid	61-73	cytochrome c, somatic	Homo sapiens	135-147
16012738-8	2005	Experimentally, we found that anti-apoptotic Bcl-2 protein levels decreased after ursolic acid treatment, while Bax expression increased.	ursolic acid	82-94	BCL2 apoptosis regulator	Homo sapiens	45-50
16012738-9	2005	Our results indicated that ursolic acid induced apoptotic processes in these poorly differentiated endometrial cancer cells occurs through mechanisms involving mitochondrial pathways and Bcl-2 family proteins.	ursolic acid	27-39	BCL2 apoptosis regulator	Homo sapiens	187-192
15649620-5	2005	Concomitant treatment with UA and pentoxifylline, a TNF-alpha synthesis inhibitor, to RAW 264.7 cells decreased the effects of UA on the MT induction.	ursolic acid	27-29	tumor necrosis factor	Mus musculus	52-61
15649620-5	2005	Concomitant treatment with UA and pentoxifylline, a TNF-alpha synthesis inhibitor, to RAW 264.7 cells decreased the effects of UA on the MT induction.	ursolic acid	127-129	tumor necrosis factor	Mus musculus	52-61
15649620-6	2005	In UA-exposed RAW 264.7 cell cultures, TNF-alpha and IL-6 production and TNF-alpha and IL-6 mRNA levels increased.	ursolic acid	3-5	tumor necrosis factor	Mus musculus	39-48
15649620-8	2005	These results demonstrate that UA induces hepatic MT expression through TNF-alpha and IL-6 released from UA-activated macrophages, which may be the mechanism, whereby UA elicits its biological effects.	ursolic acid	31-33	interleukin 6	Mus musculus	86-90
15649620-6	2005	In UA-exposed RAW 264.7 cell cultures, TNF-alpha and IL-6 production and TNF-alpha and IL-6 mRNA levels increased.	ursolic acid	3-5	interleukin 6	Mus musculus	53-57
15649620-8	2005	These results demonstrate that UA induces hepatic MT expression through TNF-alpha and IL-6 released from UA-activated macrophages, which may be the mechanism, whereby UA elicits its biological effects.	ursolic acid	105-107	interleukin 6	Mus musculus	86-90
15649620-6	2005	In UA-exposed RAW 264.7 cell cultures, TNF-alpha and IL-6 production and TNF-alpha and IL-6 mRNA levels increased.	ursolic acid	3-5	tumor necrosis factor	Mus musculus	73-82
15649620-6	2005	In UA-exposed RAW 264.7 cell cultures, TNF-alpha and IL-6 production and TNF-alpha and IL-6 mRNA levels increased.	ursolic acid	3-5	interleukin 6	Mus musculus	87-91
15649620-8	2005	These results demonstrate that UA induces hepatic MT expression through TNF-alpha and IL-6 released from UA-activated macrophages, which may be the mechanism, whereby UA elicits its biological effects.	ursolic acid	105-107	interleukin 6	Mus musculus	86-90
15649620-7	2005	When antibodies to TNF-alpha or/and IL-6 were added to UA-treated conditioned media from RAW 264.7, the MT induction activity was inhibited.	ursolic acid	55-57	tumor necrosis factor	Mus musculus	19-28
15583801-0	2005	Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells.	ursolic acid	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	21-24
15649620-7	2005	When antibodies to TNF-alpha or/and IL-6 were added to UA-treated conditioned media from RAW 264.7, the MT induction activity was inhibited.	ursolic acid	55-57	interleukin 6	Mus musculus	36-40
15523687-0	2005	Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells.	ursolic acid	0-12	caspase 3	Homo sapiens	75-84
15523687-4	2005	In this report, we demonstrated for the first time that UA had a significant antiproliferative effect on M4Beu, associated with the induction of an apoptotic process, characterized by caspase-3 activation, the downstream central effector of apoptosis.	ursolic acid	56-58	caspase 3	Homo sapiens	184-193
15523687-5	2005	We demonstrated that UA-induced apoptosis was dependent on the mitochondrial intrinsic pathway, as shown by transmembrane potential collapse (DeltaPsim) and by alteration of the Bax-Bcl-2 balance, with a concomitant increase in Bax expression and decrease in Bcl-2 expression.	ursolic acid	21-23	BCL2 associated X, apoptosis regulator	Homo sapiens	178-181
15523687-5	2005	We demonstrated that UA-induced apoptosis was dependent on the mitochondrial intrinsic pathway, as shown by transmembrane potential collapse (DeltaPsim) and by alteration of the Bax-Bcl-2 balance, with a concomitant increase in Bax expression and decrease in Bcl-2 expression.	ursolic acid	21-23	BCL2 apoptosis regulator	Homo sapiens	182-187
15523687-5	2005	We demonstrated that UA-induced apoptosis was dependent on the mitochondrial intrinsic pathway, as shown by transmembrane potential collapse (DeltaPsim) and by alteration of the Bax-Bcl-2 balance, with a concomitant increase in Bax expression and decrease in Bcl-2 expression.	ursolic acid	21-23	BCL2 associated X, apoptosis regulator	Homo sapiens	228-231
15523687-5	2005	We demonstrated that UA-induced apoptosis was dependent on the mitochondrial intrinsic pathway, as shown by transmembrane potential collapse (DeltaPsim) and by alteration of the Bax-Bcl-2 balance, with a concomitant increase in Bax expression and decrease in Bcl-2 expression.	ursolic acid	21-23	BCL2 apoptosis regulator	Homo sapiens	259-264
15583801-12	2005	After ursolic acid treatment, the anti-apoptotic Bcl-2 protein decreased and Bax expression was enhanced.	ursolic acid	6-18	BCL2 apoptosis regulator	Homo sapiens	49-54
15583801-12	2005	After ursolic acid treatment, the anti-apoptotic Bcl-2 protein decreased and Bax expression was enhanced.	ursolic acid	6-18	BCL2 associated X, apoptosis regulator	Homo sapiens	77-80
15583801-13	2005	Our results indicated that ursolic acid induced apoptotic processes in the endometrial cancer SNG-II cell line through mechanisms involving mitochondrial pathways and Bcl-2 family proteins.	ursolic acid	27-39	BCL2 apoptosis regulator	Homo sapiens	167-172
15583801-0	2005	Ursolic acid induces Bax-dependent apoptosis through the caspase-3 pathway in endometrial cancer SNG-II cells.	ursolic acid	0-12	caspase 3	Homo sapiens	57-66
15583801-4	2005	We also investigated the active forms of caspase-3, -8 and -9 in ursolic acid-treated SNG-II cells.	ursolic acid	65-77	caspase 3	Homo sapiens	41-61
15583801-5	2005	At 25 and 50 microM strength, ursolic acid induced marked increases in caspase-3 activity to approximately 5-fold that of control cells.	ursolic acid	30-42	caspase 3	Homo sapiens	71-80
15583801-8	2005	Ursolic acid treatment also resulted in a cleavage of poly (ADP-ribose) polymerase in a dose-dependent manner.	ursolic acid	0-12	poly(ADP-ribose) polymerase 1	Homo sapiens	54-82
15583801-9	2005	Testing whether caspase-3 activation and DNA polymerase activity were inhibited by addition of Ac-DEDV-HCO during ursolic acid treatment showed that 50 microM Ac-DEDV-HCO inhibited caspase-3 activity in treated cells.	ursolic acid	114-126	caspase 3	Homo sapiens	16-25
15583801-9	2005	Testing whether caspase-3 activation and DNA polymerase activity were inhibited by addition of Ac-DEDV-HCO during ursolic acid treatment showed that 50 microM Ac-DEDV-HCO inhibited caspase-3 activity in treated cells.	ursolic acid	114-126	caspase 3	Homo sapiens	181-190
15350828-4	2004	The results showed that UA blocked cell cycle progression in the G1 phase that was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner cdk2, 4, and 6 with concomitant induction of p21/WAF1.	ursolic acid	24-26	cyclin D1	Homo sapiens	146-155
15350828-4	2004	The results showed that UA blocked cell cycle progression in the G1 phase that was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner cdk2, 4, and 6 with concomitant induction of p21/WAF1.	ursolic acid	24-26	cyclin dependent kinase 2	Homo sapiens	196-200
15350828-4	2004	The results showed that UA blocked cell cycle progression in the G1 phase that was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner cdk2, 4, and 6 with concomitant induction of p21/WAF1.	ursolic acid	24-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	241-244
15350828-4	2004	The results showed that UA blocked cell cycle progression in the G1 phase that was associated with a marked decrease in the protein expression of cyclin D1, D2, and E and their activating partner cdk2, 4, and 6 with concomitant induction of p21/WAF1.	ursolic acid	24-26	cyclin dependent kinase inhibitor 1A	Homo sapiens	245-249
15043991-0	2004	Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes.	ursolic acid	63-75	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	14-29
15147868-0	2004	Ursolic acid, an antagonist for transforming growth factor (TGF)-beta1.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	32-70
15147868-2	2004	We now report the effects of ursolic acid on TGF-beta1 receptor binding and TGF-beta1-induced cellular functions in vitro.	ursolic acid	29-41	transforming growth factor beta 1	Homo sapiens	45-54
15147868-2	2004	We now report the effects of ursolic acid on TGF-beta1 receptor binding and TGF-beta1-induced cellular functions in vitro.	ursolic acid	29-41	transforming growth factor beta 1	Homo sapiens	76-85
15147868-3	2004	Ursolic acid inhibited [(125)I]-TGF-beta1 receptor binding to Balb/c 3T3 mouse fibroblasts with an IC(50) value of 6.9+/-0.8 microM.	ursolic acid	0-12	transforming growth factor, beta 1	Mus musculus	32-41
15147868-4	2004	Ursolic acid dose-dependently recovered reduced proliferation of Minc Mv1Lu cells in the presence of 5 nM of TGF-beta1 and attenuated TGF-beta1-induced collagen synthesis and production in human fibroblasts.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	109-118
15147868-4	2004	Ursolic acid dose-dependently recovered reduced proliferation of Minc Mv1Lu cells in the presence of 5 nM of TGF-beta1 and attenuated TGF-beta1-induced collagen synthesis and production in human fibroblasts.	ursolic acid	0-12	transforming growth factor beta 1	Homo sapiens	134-143
15147868-5	2004	Molecular dynamics simulations suggest that ursolic acid may interact with the hydrophobic region of the dimeric interface and thereby inhibit the binding of TGF-beta1 to its receptor.	ursolic acid	44-56	transforming growth factor beta 1	Homo sapiens	158-167
15147868-6	2004	All these findings taken together show that ursolic acid functions as an antagonist for TGF-beta1.	ursolic acid	44-56	transforming growth factor beta 1	Homo sapiens	88-97
15043991-3	2004	UA competitively inhibited CYP2C19-catalyzed S-mephenytoin 4"-hydroxylation with an IC50 (Ki) value of 119.7 (80.3) microM.	ursolic acid	0-2	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	27-34
12969763-6	2003	Pretreatment with asiatic acid or ursolic acid significantly reduced the UVA-induced activation and expression of MMP-2.	ursolic acid	34-46	matrix metallopeptidase 2	Homo sapiens	114-119
12969763-7	2003	In addition, UVA-induced enhanced expression of p53, a hallmark of UV-induced DNA damage and cell death, was also significantly inhibited by pretreatment with asiatic acid or ursolic acid.	ursolic acid	175-187	tumor protein p53	Homo sapiens	48-51
12907607-12	2003	Thus, overall, our results indicate that ursolic acid inhibits IkappaBalpha kinase and p65 phosphorylation, leading to the suppression of NF-kappaB activation induced by various carcinogens.	ursolic acid	41-53	NFKB inhibitor alpha	Homo sapiens	63-75
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	22-43
12907607-12	2003	Thus, overall, our results indicate that ursolic acid inhibits IkappaBalpha kinase and p65 phosphorylation, leading to the suppression of NF-kappaB activation induced by various carcinogens.	ursolic acid	41-53	RELA proto-oncogene, NF-kB subunit	Homo sapiens	87-90
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	NFKB inhibitor alpha	Homo sapiens	109-121
12907607-12	2003	Thus, overall, our results indicate that ursolic acid inhibits IkappaBalpha kinase and p65 phosphorylation, leading to the suppression of NF-kappaB activation induced by various carcinogens.	ursolic acid	41-53	nuclear factor kappa B subunit 1	Homo sapiens	138-147
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	133-136
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	190-206
12792782-0	2003	Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells.	ursolic acid	0-12	caspase 3	Homo sapiens	39-48
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	matrix metallopeptidase 9	Homo sapiens	208-234
12907607-0	2003	Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.	ursolic acid	0-12	cyclin D1	Homo sapiens	240-249
12907607-6	2003	In the study described in the present report, we found that ursolic acid suppressed NF-kappaB activation induced by various carcinogens including tumor necrosis factor (TNF), phorbol ester, okadaic acid, H(2)O(2), and cigarette smoke.	ursolic acid	60-72	nuclear factor kappa B subunit 1	Homo sapiens	84-93
12907607-6	2003	In the study described in the present report, we found that ursolic acid suppressed NF-kappaB activation induced by various carcinogens including tumor necrosis factor (TNF), phorbol ester, okadaic acid, H(2)O(2), and cigarette smoke.	ursolic acid	60-72	tumor necrosis factor	Homo sapiens	146-167
12907607-6	2003	In the study described in the present report, we found that ursolic acid suppressed NF-kappaB activation induced by various carcinogens including tumor necrosis factor (TNF), phorbol ester, okadaic acid, H(2)O(2), and cigarette smoke.	ursolic acid	60-72	tumor necrosis factor	Homo sapiens	169-172
12907607-8	2003	Ursolic acid inhibited DNA binding of NF-kappaB consisting of p50 and p65.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	38-47
12907607-8	2003	Ursolic acid inhibited DNA binding of NF-kappaB consisting of p50 and p65.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	62-65
12907607-8	2003	Ursolic acid inhibited DNA binding of NF-kappaB consisting of p50 and p65.	ursolic acid	0-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	70-73
12907607-9	2003	Ursolic acid inhibited IkappaBalpha degradation, IkappaBalpha phosphorylation, IkappaBalpha kinase activation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression.	ursolic acid	0-12	NFKB inhibitor alpha	Homo sapiens	23-35
12907607-9	2003	Ursolic acid inhibited IkappaBalpha degradation, IkappaBalpha phosphorylation, IkappaBalpha kinase activation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression.	ursolic acid	0-12	NFKB inhibitor alpha	Homo sapiens	49-61
12907607-9	2003	Ursolic acid inhibited IkappaBalpha degradation, IkappaBalpha phosphorylation, IkappaBalpha kinase activation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression.	ursolic acid	0-12	NFKB inhibitor alpha	Homo sapiens	49-61
12907607-9	2003	Ursolic acid inhibited IkappaBalpha degradation, IkappaBalpha phosphorylation, IkappaBalpha kinase activation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression.	ursolic acid	0-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	111-114
12907607-9	2003	Ursolic acid inhibited IkappaBalpha degradation, IkappaBalpha phosphorylation, IkappaBalpha kinase activation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression.	ursolic acid	0-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	132-135
12907607-9	2003	Ursolic acid inhibited IkappaBalpha degradation, IkappaBalpha phosphorylation, IkappaBalpha kinase activation, p65 phosphorylation, p65 nuclear translocation, and NF-kappaB-dependent reporter gene expression.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	163-172
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	28-37
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	tumor necrosis factor	Homo sapiens	86-89
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	tumor necrosis factor	Homo sapiens	100-103
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	tumor necrosis factor	Homo sapiens	100-103
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	170-179
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	NFKB inhibitor alpha	Homo sapiens	197-209
12907607-10	2003	Ursolic acid also inhibited NF-kappaB-dependent reporter gene expression activated by TNF receptor, TNF receptor-associated death domain, TNF receptor-associated factor, NF-kappaB-inducing kinase, IkappaBalpha kinase, and p65.	ursolic acid	0-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	222-225
12926069-8	2003	RESULTS: UA dose-dependently decreased cell proliferation and induced apoptosis, accompanied by activation of caspase 3, 8 and 9.	ursolic acid	9-11	caspase 3	Homo sapiens	110-128
12792782-6	2003	During UA treatment, we also demonstrated that p53 was phosphorylated at serine 392 and translocated to the nucleus.	ursolic acid	7-9	tumor protein p53	Homo sapiens	47-50
12792782-9	2003	In conclusion, our results suggest that UA induces: i) cell cycle arrest concomitantly with the apparition of the apoptotic sub group G1 peak, and ii) cell death through apoptosis, which is mediated by caspase-3.	ursolic acid	40-42	caspase 3	Homo sapiens	202-211
11911474-0	2002	Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury.	ursolic acid	0-12	amyloid beta precursor protein	Rattus norvegicus	45-50
11911474-2	2002	The effect of ursolic acid from Origanum majorana L. on Abeta-induced neurotoxicity was investigated using PC12 cells.	ursolic acid	14-26	amyloid beta precursor protein	Rattus norvegicus	56-61
11911474-3	2002	Pretreatment with isolated ursolic acid and vitamin E prevented the PC12 cell from reactive oxygen species (ROS) toxicity that is mediated by Abeta.	ursolic acid	27-39	amyloid beta precursor protein	Rattus norvegicus	142-147
11741581-3	2001	We found that UA elicited a dose-dependent increase in NO and TNF-alpha production, and the level of iNOS and TNF-alpha mRNA.	ursolic acid	14-16	tumor necrosis factor	Mus musculus	62-71
11911474-6	2002	Therefore, these results indicate that micromolar Abeta-induced oxidative cell death is reduced by ursolic acid from Origanum majorana L.	ursolic acid	99-111	amyloid beta precursor protein	Rattus norvegicus	50-55
11741581-3	2001	We found that UA elicited a dose-dependent increase in NO and TNF-alpha production, and the level of iNOS and TNF-alpha mRNA.	ursolic acid	14-16	nitric oxide synthase 2, inducible	Mus musculus	101-105
11741581-3	2001	We found that UA elicited a dose-dependent increase in NO and TNF-alpha production, and the level of iNOS and TNF-alpha mRNA.	ursolic acid	14-16	tumor necrosis factor	Mus musculus	110-119
11741581-5	2001	These results demonstrate that UA stimulates NO and TNF-alpha release and is able to upregulate iNOS and TNF-alpha expression through NF-kappaB transactivation in the resting macrophages.	ursolic acid	31-33	tumor necrosis factor	Mus musculus	52-61
11741581-5	2001	These results demonstrate that UA stimulates NO and TNF-alpha release and is able to upregulate iNOS and TNF-alpha expression through NF-kappaB transactivation in the resting macrophages.	ursolic acid	31-33	nitric oxide synthase 2, inducible	Mus musculus	96-100
11741581-5	2001	These results demonstrate that UA stimulates NO and TNF-alpha release and is able to upregulate iNOS and TNF-alpha expression through NF-kappaB transactivation in the resting macrophages.	ursolic acid	31-33	tumor necrosis factor	Mus musculus	105-114
10925354-4	2000	Furthermore, 30 microM of UA induced DNA fragmentation and subdiploid cells and enhanced the release of cytochrome c and the activation of caspase-3.	ursolic acid	26-28	cytochrome c, somatic	Homo sapiens	104-116
11848513-0	2001	Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis.	ursolic acid	55-67	caspase 3	Homo sapiens	14-23
11848513-5	2001	Similarly to these results, ursolic acid effectively induced proteolytic activation of caspase-3 protease in a dose-dependent manner while its derivative showed only weak activity in this enzyme assay.	ursolic acid	28-40	caspase 3	Homo sapiens	87-96
11484840-1	2001	The purpose of this study was to investigate possible protective effects of ursolic acid against CCl4-induced alterations of antioxidant defence enzymes in vivo as well as its effects against CCl4-intoxication in vitro.	ursolic acid	76-88	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
11484840-2	2001	Pre-treatment of rats with ursolic acid significantly reduced serum levels of glutamate-oxalate-transaminase and glutamate-pyruvate-transaminase previously increased by administration of CCl4.	ursolic acid	27-39	C-C motif chemokine ligand 4	Rattus norvegicus	187-191
11484840-3	2001	Treatment with ursolic acid also significantly reversed the decreased superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase activities and glutathione levels in the liver, as the concentration of reduced glutathione was increased and the content of oxidized glutathione decreased in ursolic acid treated groups.	ursolic acid	15-27	catalase	Rattus norvegicus	92-100
11484840-3	2001	Treatment with ursolic acid also significantly reversed the decreased superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase activities and glutathione levels in the liver, as the concentration of reduced glutathione was increased and the content of oxidized glutathione decreased in ursolic acid treated groups.	ursolic acid	15-27	glutathione-disulfide reductase	Rattus norvegicus	102-123
11484840-5	2001	In vitro results indicated that addition to the culture medium of ursolic acid (p &lt; 0.01 for 500 microM) resulted in a reduction of glutamate-oxalate-transaminase, lactate dehydrogenase activities and in a good survival rate for the CCl4-intoxicated hepatocytes.	ursolic acid	66-78	C-C motif chemokine ligand 4	Rattus norvegicus	236-240
11484840-6	2001	Ursolic acid also ameliorated lipid peroxidation in primary cultured rat hepatocytes exposed to CCl4, as demonstrated by a reduction in malondialdehyde production.	ursolic acid	0-12	C-C motif chemokine ligand 4	Rattus norvegicus	96-100
11484840-8	2001	The results obtained suggest that ursolic acid treatment can normalize the disturbed antioxidant status of rats intoxicated with CCl4 by maintaining the levels of glutathione and by inhibiting the production of malondialdehyde due to its radical scavenging properties.	ursolic acid	34-46	C-C motif chemokine ligand 4	Rattus norvegicus	129-133
10938399-0	2000	Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells.	ursolic acid	26-38	caspase 1	Homo sapiens	61-69
10925354-4	2000	Furthermore, 30 microM of UA induced DNA fragmentation and subdiploid cells and enhanced the release of cytochrome c and the activation of caspase-3.	ursolic acid	26-28	caspase 3	Homo sapiens	139-148
10938399-5	2000	These apoptotic effects of UA were accompanied by proteolytic cleavage of specific target proteins such as PARP, beta-catenin and Rad51 proteins suggesting the possible involvement of caspases.	ursolic acid	27-29	collagen type XI alpha 2 chain	Homo sapiens	107-111
10938399-5	2000	These apoptotic effects of UA were accompanied by proteolytic cleavage of specific target proteins such as PARP, beta-catenin and Rad51 proteins suggesting the possible involvement of caspases.	ursolic acid	27-29	catenin beta 1	Homo sapiens	113-125
10925354-5	2000	These results suggest that UA induces cell death through apoptosis, which may be mediated by cytochrome c-dependent caspase-3 activation.	ursolic acid	27-29	cytochrome c, somatic	Homo sapiens	93-105
10938399-5	2000	These apoptotic effects of UA were accompanied by proteolytic cleavage of specific target proteins such as PARP, beta-catenin and Rad51 proteins suggesting the possible involvement of caspases.	ursolic acid	27-29	RAD51 recombinase	Homo sapiens	130-135
10925354-5	2000	These results suggest that UA induces cell death through apoptosis, which may be mediated by cytochrome c-dependent caspase-3 activation.	ursolic acid	27-29	caspase 3	Homo sapiens	116-125
10938399-5	2000	These apoptotic effects of UA were accompanied by proteolytic cleavage of specific target proteins such as PARP, beta-catenin and Rad51 proteins suggesting the possible involvement of caspases.	ursolic acid	27-29	caspase 1	Homo sapiens	184-192
10938399-6	2000	Western blotting and in vitro assay demonstrated that processing/activation of at least four caspases (caspase-1, -3, -8 and -9) accompanies the generation of UA-mediating apoptotic cell death.	ursolic acid	159-161	caspase 1	Homo sapiens	93-101
10938399-6	2000	Western blotting and in vitro assay demonstrated that processing/activation of at least four caspases (caspase-1, -3, -8 and -9) accompanies the generation of UA-mediating apoptotic cell death.	ursolic acid	159-161	caspase 1	Homo sapiens	103-127
10938399-9	2000	These data suggest that apoptotic signals evoked by UA treatment may converge caspases activation through down-regulation of c-IAPs family and without mitochondrial dysfunction.	ursolic acid	52-54	caspase 1	Homo sapiens	78-86
10925354-7	2000	Moreover, expression of p21(WAF1), a cell-cycle regulator, was increased by UA, indicating that p21(WAF1) might mediate UA-induced cell-cycle arrest.	ursolic acid	76-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	24-27
10925354-7	2000	Moreover, expression of p21(WAF1), a cell-cycle regulator, was increased by UA, indicating that p21(WAF1) might mediate UA-induced cell-cycle arrest.	ursolic acid	76-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	28-32
10925354-7	2000	Moreover, expression of p21(WAF1), a cell-cycle regulator, was increased by UA, indicating that p21(WAF1) might mediate UA-induced cell-cycle arrest.	ursolic acid	76-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-99
10925354-7	2000	Moreover, expression of p21(WAF1), a cell-cycle regulator, was increased by UA, indicating that p21(WAF1) might mediate UA-induced cell-cycle arrest.	ursolic acid	76-78	cyclin dependent kinase inhibitor 1A	Homo sapiens	100-104
10925354-10	2000	Taken together, we suggest that UA-induced cell-cycle arrest may be mediated by inhibition of DNA replication and the increase of p21(WAF1) expression, which induces the release of cytochrome c and the activation of caspase-3, leading to apoptosis of HepG2 cells.	ursolic acid	32-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	130-133
10925354-10	2000	Taken together, we suggest that UA-induced cell-cycle arrest may be mediated by inhibition of DNA replication and the increase of p21(WAF1) expression, which induces the release of cytochrome c and the activation of caspase-3, leading to apoptosis of HepG2 cells.	ursolic acid	32-34	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-138
10925354-10	2000	Taken together, we suggest that UA-induced cell-cycle arrest may be mediated by inhibition of DNA replication and the increase of p21(WAF1) expression, which induces the release of cytochrome c and the activation of caspase-3, leading to apoptosis of HepG2 cells.	ursolic acid	32-34	cytochrome c, somatic	Homo sapiens	181-193
10925354-10	2000	Taken together, we suggest that UA-induced cell-cycle arrest may be mediated by inhibition of DNA replication and the increase of p21(WAF1) expression, which induces the release of cytochrome c and the activation of caspase-3, leading to apoptosis of HepG2 cells.	ursolic acid	32-34	caspase 3	Homo sapiens	216-225
10811116-0	2000	Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells.	ursolic acid	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	22-38
10811116-7	2000	Treatment with PMA increased activator protein-1 activity and the binding of c-Jun to the cyclic AMP response element of the COX-2 promoter, effects that were blocked by ursolic acid.	ursolic acid	170-182	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-48
10811116-1	2000	We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells.	ursolic acid	31-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	91-107
10811116-7	2000	Treatment with PMA increased activator protein-1 activity and the binding of c-Jun to the cyclic AMP response element of the COX-2 promoter, effects that were blocked by ursolic acid.	ursolic acid	170-182	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	77-82
10811116-1	2000	We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate (PMA)-treated human mammary and oral epithelial cells.	ursolic acid	31-43	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
10811116-7	2000	Treatment with PMA increased activator protein-1 activity and the binding of c-Jun to the cyclic AMP response element of the COX-2 promoter, effects that were blocked by ursolic acid.	ursolic acid	170-182	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-130
10811116-2	2000	Treatment with ursolic acid suppressed PMA-mediated induction of COX-2 protein and synthesis of prostaglandin E2.	ursolic acid	15-27	prostaglandin-endoperoxide synthase 2	Homo sapiens	65-70
10811116-3	2000	Ursolic acid also suppressed the induction of COX-2 mRNA by PMA.	ursolic acid	0-12	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-51
10811116-4	2000	Nuclear run-offs revealed increased rates of COX-2 transcription after treatment with PMA, an effect that was inhibited by ursolic acid.	ursolic acid	123-135	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-50
10811116-6	2000	Ursolic acid inhibited PMA-mediated activation of protein kinase C, extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinases.	ursolic acid	0-12	mitogen-activated protein kinase 3	Homo sapiens	68-134
10811116-6	2000	Ursolic acid inhibited PMA-mediated activation of protein kinase C, extracellular signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinases.	ursolic acid	0-12	mitogen-activated protein kinase 14	Homo sapiens	140-143
9485026-6	1998	The 3-alpha(axial)-epimer of ursolic acid suppressed de novo formation of COX-2, in contrast to naturally occurring 3-beta(equatorial)-ursolic acid.	ursolic acid	29-41	cytochrome c oxidase II, mitochondrial	Mus musculus	74-79
10656538-3	1999	Also, ursolic acid found in herbal medicines (e.g. leaves of loquat) was reported to increase catalase (CAT) activities in mouse liver.	ursolic acid	6-18	catalase	Mus musculus	104-107
8625299-5	1996	Quantitative gelatin-based zymography confirmed a markedly reduced expression of MMP-9 but not MMP-2 after treatment with UA.	ursolic acid	122-124	matrix metallopeptidase 9	Homo sapiens	81-86
9488041-0	1998	Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells.	ursolic acid	0-12	matrix metallopeptidase 9	Homo sapiens	40-45
9488041-0	1998	Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells.	ursolic acid	0-12	nuclear receptor subfamily 3 group C member 1	Homo sapiens	100-123
9488041-1	1998	We have previously reported that ursolic acid, a pentacyclic triterpene acid, inhibited the invasion of HT1080 human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9.	ursolic acid	33-45	matrix metallopeptidase 9	Homo sapiens	166-192
9488041-5	1998	In Northern blot analysis, we found that ursolic acid reduced the expression of matrix metalloproteinase-1 and matrix metalloproteinase-3 induced by 2-O-tetradecanoylphorbol-acetate.	ursolic acid	41-53	matrix metallopeptidase 1	Homo sapiens	80-137
9488041-6	1998	Similarly, ursolic acid down-regulated 2-O-tetradecanoylphorbol-acetate-induction of matrix metalloproteinase-9 gene in the same manner of dexamethasone.	ursolic acid	11-23	matrix metallopeptidase 9	Homo sapiens	85-111
9488041-7	1998	RU486, a potent glucocorticoid receptor antagonist, was used for identifying that ursolic acid-induced down-regulation of matrix metalloproteinase-9 expression is mediated by its binding to glucocorticoid receptor.	ursolic acid	82-94	nuclear receptor subfamily 3 group C member 1	Homo sapiens	16-39
9488041-7	1998	RU486, a potent glucocorticoid receptor antagonist, was used for identifying that ursolic acid-induced down-regulation of matrix metalloproteinase-9 expression is mediated by its binding to glucocorticoid receptor.	ursolic acid	82-94	matrix metallopeptidase 9	Homo sapiens	122-148
9488041-7	1998	RU486, a potent glucocorticoid receptor antagonist, was used for identifying that ursolic acid-induced down-regulation of matrix metalloproteinase-9 expression is mediated by its binding to glucocorticoid receptor.	ursolic acid	82-94	nuclear receptor subfamily 3 group C member 1	Homo sapiens	190-213
9488041-8	1998	The effect of ursolic acid on the matrix metalloproteinase-9 expression was blocked by RU486, suggesting that ursolic acid acts via a glucocorticoid receptor in the regulation of matrix metalloproteinase-9.	ursolic acid	14-26	matrix metallopeptidase 9	Homo sapiens	34-60
9488041-8	1998	The effect of ursolic acid on the matrix metalloproteinase-9 expression was blocked by RU486, suggesting that ursolic acid acts via a glucocorticoid receptor in the regulation of matrix metalloproteinase-9.	ursolic acid	14-26	nuclear receptor subfamily 3 group C member 1	Homo sapiens	134-157
9488041-8	1998	The effect of ursolic acid on the matrix metalloproteinase-9 expression was blocked by RU486, suggesting that ursolic acid acts via a glucocorticoid receptor in the regulation of matrix metalloproteinase-9.	ursolic acid	14-26	matrix metallopeptidase 9	Homo sapiens	179-205
9488041-8	1998	The effect of ursolic acid on the matrix metalloproteinase-9 expression was blocked by RU486, suggesting that ursolic acid acts via a glucocorticoid receptor in the regulation of matrix metalloproteinase-9.	ursolic acid	110-122	matrix metallopeptidase 9	Homo sapiens	34-60
9488041-8	1998	The effect of ursolic acid on the matrix metalloproteinase-9 expression was blocked by RU486, suggesting that ursolic acid acts via a glucocorticoid receptor in the regulation of matrix metalloproteinase-9.	ursolic acid	110-122	nuclear receptor subfamily 3 group C member 1	Homo sapiens	134-157
9488041-8	1998	The effect of ursolic acid on the matrix metalloproteinase-9 expression was blocked by RU486, suggesting that ursolic acid acts via a glucocorticoid receptor in the regulation of matrix metalloproteinase-9.	ursolic acid	110-122	matrix metallopeptidase 9	Homo sapiens	179-205
9488041-9	1998	Western blot analysis and immunocytochemistry showed that ursolic acid increased glucocorticoid receptor fraction in the nucleus, although it decreased the synthesis of glucocorticoid receptor mRNA.	ursolic acid	58-70	nuclear receptor subfamily 3 group C member 1	Homo sapiens	81-104
9488041-9	1998	Western blot analysis and immunocytochemistry showed that ursolic acid increased glucocorticoid receptor fraction in the nucleus, although it decreased the synthesis of glucocorticoid receptor mRNA.	ursolic acid	58-70	nuclear receptor subfamily 3 group C member 1	Homo sapiens	169-192
9488041-11	1998	Taken together, we suggest that ursolic acid may induce the repression of matrix metalloproteinase-9 by stimulating the nuclear translocation of glucocorticoid receptor, and the translocated glucocorticoid receptor probably down-modulating the trans-activating function of AP-1 to 2-O-tetradecanoylphorbol-acetate responsible element of matrix metalloproteinase-9 promoter region.	ursolic acid	32-44	matrix metallopeptidase 9	Homo sapiens	74-100
9488041-11	1998	Taken together, we suggest that ursolic acid may induce the repression of matrix metalloproteinase-9 by stimulating the nuclear translocation of glucocorticoid receptor, and the translocated glucocorticoid receptor probably down-modulating the trans-activating function of AP-1 to 2-O-tetradecanoylphorbol-acetate responsible element of matrix metalloproteinase-9 promoter region.	ursolic acid	32-44	nuclear receptor subfamily 3 group C member 1	Homo sapiens	145-168
9488041-11	1998	Taken together, we suggest that ursolic acid may induce the repression of matrix metalloproteinase-9 by stimulating the nuclear translocation of glucocorticoid receptor, and the translocated glucocorticoid receptor probably down-modulating the trans-activating function of AP-1 to 2-O-tetradecanoylphorbol-acetate responsible element of matrix metalloproteinase-9 promoter region.	ursolic acid	32-44	matrix metallopeptidase 9	Homo sapiens	337-363
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	ursolic acid	163-175	arachidonate 5-lipoxygenase	Homo sapiens	42-56
9103531-4	1997	The data show that the dual inhibition of 5-lipoxygenase and HLE is unique to boswellic acids: other pentacyclic triterpenes with HLE inhibitory activities (e.g., ursolic acid and amyrin) do not inhibit 5-lipoxygenase, and leukotriene biosynthesis inhibitors from different chemical classes (e.g., NDGA, MK-886 and ZM-230,487) do not impair HLE activity.	ursolic acid	163-175	elastase, neutrophil expressed	Homo sapiens	61-64
8625299-0	1996	Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells.	ursolic acid	26-38	matrix metallopeptidase 9	Homo sapiens	81-107
8625299-0	1996	Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells.	ursolic acid	26-38	matrix metallopeptidase 9	Homo sapiens	109-114
8625299-6	1996	To confirm the UA-induced down-regulation of MMP-9 expression, we constructed a secreted alkaline phosphatase (SEAP) reporter vector including MMP-9 promoter.	ursolic acid	15-17	matrix metallopeptidase 9	Homo sapiens	45-50
8625299-6	1996	To confirm the UA-induced down-regulation of MMP-9 expression, we constructed a secreted alkaline phosphatase (SEAP) reporter vector including MMP-9 promoter.	ursolic acid	15-17	matrix metallopeptidase 9	Homo sapiens	143-148
8625299-7	1996	After transfection of MMP-9/SEAP reporter vector into HT1080 cells, reduced SEAP activity was detected after treatment with UA.	ursolic acid	124-126	matrix metallopeptidase 9	Homo sapiens	22-27
8625299-8	1996	These results suggest that down-regulation of MMP-9 contributes to the anti-invasive activity of UA in HT1080 cells.	ursolic acid	97-99	matrix metallopeptidase 9	Homo sapiens	46-51
33352493-0	2021	Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.	ursolic acid	0-12	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	107-111
33805840-0	2021	Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells.	ursolic acid	21-33	signal transducer and activator of transcription 3	Homo sapiens	70-75
33805840-0	2021	Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells.	ursolic acid	21-33	CD274 molecule	Homo sapiens	76-81
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	vascular endothelial growth factor A	Homo sapiens	43-77
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	vascular endothelial growth factor A	Homo sapiens	79-83
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	matrix metallopeptidase 2	Homo sapiens	106-110
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	CD274 molecule	Homo sapiens	116-141
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	CD274 molecule	Homo sapiens	143-148
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	signal transducer and activator of transcription 3	Homo sapiens	179-184
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	matrix metallopeptidase 2	Homo sapiens	185-189
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	signal transducer and activator of transcription 3	Homo sapiens	194-199
33805840-12	2021	Furthermore, UA reduced the expressions of vascular endothelial growth factor (VEGF), metalloproteinases (MMPs) and programmed death ligand-1 (PD-L1), as well as the formation of STAT3/MMP2 and STAT3/PD-L1 complexes.	ursolic acid	13-15	CD274 molecule	Homo sapiens	200-205
33805840-13	2021	Altogether, UA exhibits anticancer activities by inhibiting MMP2 and PD-L1 expression through EGFR/JAK2/STAT3 signaling.	ursolic acid	12-14	matrix metallopeptidase 2	Homo sapiens	60-64
33805840-13	2021	Altogether, UA exhibits anticancer activities by inhibiting MMP2 and PD-L1 expression through EGFR/JAK2/STAT3 signaling.	ursolic acid	12-14	CD274 molecule	Homo sapiens	69-74
33805840-13	2021	Altogether, UA exhibits anticancer activities by inhibiting MMP2 and PD-L1 expression through EGFR/JAK2/STAT3 signaling.	ursolic acid	12-14	epidermal growth factor receptor	Homo sapiens	94-98
33805840-13	2021	Altogether, UA exhibits anticancer activities by inhibiting MMP2 and PD-L1 expression through EGFR/JAK2/STAT3 signaling.	ursolic acid	12-14	Janus kinase 2	Homo sapiens	99-103
33805840-13	2021	Altogether, UA exhibits anticancer activities by inhibiting MMP2 and PD-L1 expression through EGFR/JAK2/STAT3 signaling.	ursolic acid	12-14	signal transducer and activator of transcription 3	Homo sapiens	104-109
1567909-2	1992	This molecule was characterized as ursolic acid by GC-MS. Ursolic acid was found to be an inhibitor of both potato tuber 5-lipoxygenase and soybean 15-lipoxygenase with IC50 values of 0.3 mM.	ursolic acid	58-70	5-lipoxygenase	Solanum tuberosum	121-135
1859379-0	1991	Inhibition of human leucocyte elastase by ursolic acid.	ursolic acid	42-54	elastase, neutrophil expressed	Homo sapiens	30-38
1859379-4	1991	With tripeptide and tetrapeptide substrates, the inhibition is purely competitive, whereas with a shorter dipeptide substrate the inhibition is non-competitive, suggesting that ursolic acid interacts with subsite S3 of the extended substrate-binding domain in HLE, but not with subsites S1 and S2.	ursolic acid	177-189	elastase, neutrophil expressed	Homo sapiens	260-263
1859379-5	1991	The carboxy group at position 28 in the pentacyclic-ring system of the triterpenes contributes to binding to HLE, since replacement of this group with a hydroxy group, as in uvaol, the alcohol analogue of ursolic acid, reduces the potency of inhibition.	ursolic acid	205-217	elastase, neutrophil expressed	Homo sapiens	109-112
1859379-6	1991	The inhibitory potency of ursolic acid is also reduced by addition of 1 M-NaCl, further supporting a postulated electrostatic interaction between the negative charge on the triterpene and a positively charged residue on the enzyme, which we assign to the side chain of Arg-217, located in the vicinity of subsites S4 and S5 in HLE.	ursolic acid	26-38	elastase, neutrophil expressed	Homo sapiens	327-330
2380724-3	1990	Esterification of ursolic acid with aliphatic acids clearly enhanced the cytotoxic effects against human PLC/PRF/5 cells in vitro.	ursolic acid	18-30	heparan sulfate proteoglycan 2	Homo sapiens	105-108
33352493-0	2021	Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.	ursolic acid	0-12	Dopamine receptor 3	Caenorhabditis elegans	116-120
33352493-12	2021	We also examined the binding affinity of UA towards C. elegans Dop1 and Dop3 receptors as well as human dopamine receptors D1 and D3 by molecular docking.	ursolic acid	41-43	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	63-67
33352493-12	2021	We also examined the binding affinity of UA towards C. elegans Dop1 and Dop3 receptors as well as human dopamine receptors D1 and D3 by molecular docking.	ursolic acid	41-43	Dopamine receptor 3	Caenorhabditis elegans	72-76
33352493-16	2021	Moreover, dop1 and dop3 gene expression was significantly enhanced upon UA treatment.	ursolic acid	72-74	DOP1 leucine zipper like protein A	Homo sapiens	10-14
33352493-16	2021	Moreover, dop1 and dop3 gene expression was significantly enhanced upon UA treatment.	ursolic acid	72-74	Dopamine receptor 3	Caenorhabditis elegans	19-23
33352493-19	2021	CONCLUSION: UA reduced stress-dependent ROS generation and acted through Dop1 and to a lesser extent through Dop3 to reduce stress and prolong life span in C. elegans.	ursolic acid	12-14	G_PROTEIN_RECEP_F1_2 domain-containing protein	Caenorhabditis elegans	73-77
33352493-19	2021	CONCLUSION: UA reduced stress-dependent ROS generation and acted through Dop1 and to a lesser extent through Dop3 to reduce stress and prolong life span in C. elegans.	ursolic acid	12-14	Dopamine receptor 3	Caenorhabditis elegans	109-113
34902447-0	2022	Ursolic acid ameliorates amyloid beta-induced pathological symptoms in Caenorhabditis elegans by activating the proteasome.	ursolic acid	0-12	amyloid beta precursor protein	Homo sapiens	25-37
25459994-7	2015	RESULTS: Ursolic acid significantly prevented CCl4-induced hepatotoxicity and fibrosis, indicated by both diagnostic indicators and histopathological analysis.	ursolic acid	9-21	chemokine (C-C motif) ligand 4	Mus musculus	46-50
25459994-8	2015	CCl4-induced profound elevations of oxidative stress, inflammation and apoptosis in liver were suppressed by ursolic acid.	ursolic acid	109-121	chemokine (C-C motif) ligand 4	Mus musculus	0-4
25459994-10	2015	The inhibition of CCl4-induced liver fibrosis, inflammation and apoptosis by ursolic acid is due at least in part to its ability to modulate the Nrf2/ARE signalling pathway.	ursolic acid	77-89	chemokine (C-C motif) ligand 4	Mus musculus	18-22
25459994-10	2015	The inhibition of CCl4-induced liver fibrosis, inflammation and apoptosis by ursolic acid is due at least in part to its ability to modulate the Nrf2/ARE signalling pathway.	ursolic acid	77-89	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
34688014-0	2022	Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors.	ursolic acid	45-57	SUMO specific peptidase 1	Homo sapiens	73-78
34688014-4	2022	Herein, based on the structure of ursolic acid (UA), a total of 53 pentacyclic triterpene derivatives were designed and synthesized as SENP1 inhibitors.	ursolic acid	34-46	SUMO specific peptidase 1	Homo sapiens	135-140
34688014-4	2022	Herein, based on the structure of ursolic acid (UA), a total of 53 pentacyclic triterpene derivatives were designed and synthesized as SENP1 inhibitors.	ursolic acid	48-50	SUMO specific peptidase 1	Homo sapiens	135-140
25459994-0	2015	Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway.	ursolic acid	22-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
25459994-2	2015	In this study, we aimed to investigate the possible protective effects of ursolic acid in liver fibrosis induced by carbon tetrachloride (CCl4).	ursolic acid	74-86	chemokine (C-C motif) ligand 4	Mus musculus	138-142
34762347-5	2022	Notably, these classes of compounds exhibited more significant inhibition against protein-tyrosine phosphatase 1B (PTP1B) enzyme better than standard compound, ursolic acid.	ursolic acid	160-172	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	82-113
34762347-5	2022	Notably, these classes of compounds exhibited more significant inhibition against protein-tyrosine phosphatase 1B (PTP1B) enzyme better than standard compound, ursolic acid.	ursolic acid	160-172	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	115-120
34902447-12	2022	Ursolic acid transcriptionally enhanced the ubiquitin-proteasome system and augmented proteasome activity in vivo.	ursolic acid	0-12	Ubiquitin	Caenorhabditis elegans	44-53
34902447-14	2022	CONCLUSIONS: Our study revealed that ursolic acid prevented amyloid beta-induced proteotoxic stress, specifically by reducing the amount of amyloid beta and increasing proteasome activity in vivo.	ursolic acid	37-49	amyloid beta precursor protein	Homo sapiens	60-72
34902447-14	2022	CONCLUSIONS: Our study revealed that ursolic acid prevented amyloid beta-induced proteotoxic stress, specifically by reducing the amount of amyloid beta and increasing proteasome activity in vivo.	ursolic acid	37-49	amyloid beta precursor protein	Homo sapiens	140-152
34902447-15	2022	Furthermore, the therapeutic effect of ursolic acid on transgenic nematodes expressing amyloid beta depended on the increased activity of the proteasome.	ursolic acid	39-51	amyloid beta precursor protein	Homo sapiens	87-99
34902447-10	2022	RESULTS: In our study, ursolic acid successfully repressed amyloid beta-induced paralysis and hypersensitivity to serotonin in Caenorhabditis elegans.	ursolic acid	23-35	amyloid beta precursor protein	Homo sapiens	59-71
34902447-11	2022	The levels of amyloid beta monomers, oligomers, and deposits were decreased after treatment with ursolic acid in transgenic nematodes overexpressing human amyloid beta; however, ursolic acid did not affect exogenous transgene transcription and expression levels.	ursolic acid	97-109	amyloid beta precursor protein	Homo sapiens	14-26
34902447-11	2022	The levels of amyloid beta monomers, oligomers, and deposits were decreased after treatment with ursolic acid in transgenic nematodes overexpressing human amyloid beta; however, ursolic acid did not affect exogenous transgene transcription and expression levels.	ursolic acid	97-109	amyloid beta precursor protein	Homo sapiens	155-167
34902447-11	2022	The levels of amyloid beta monomers, oligomers, and deposits were decreased after treatment with ursolic acid in transgenic nematodes overexpressing human amyloid beta; however, ursolic acid did not affect exogenous transgene transcription and expression levels.	ursolic acid	178-190	amyloid beta precursor protein	Homo sapiens	14-26
34506233-4	2021	The results manifested that high- and low-dose UA reduced COM crystals in COM rats" kidney, down-regulated urea, creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) levels in rat plasma, declined kidney tissue and HK-2 cell apoptosis, inhibited Bax expression but elevated Bcl-2 expression.	ursolic acid	47-49	lipocalin 2	Rattus norvegicus	129-171
34897590-7	2022	In addition, treatment with QHJ plus NTRK1 significantly enhanced cell apoptosis and inhibition of cell proliferation compared with cells treated with QHJ only (P<0.05), particularly in cells treated with ursolic acid.	ursolic acid	205-217	neurotrophic receptor tyrosine kinase 1	Homo sapiens	37-42
34751064-0	2021	Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity.	ursolic acid	22-34	C-C motif chemokine ligand 4	Rattus norvegicus	51-55
34506233-4	2021	The results manifested that high- and low-dose UA reduced COM crystals in COM rats" kidney, down-regulated urea, creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) levels in rat plasma, declined kidney tissue and HK-2 cell apoptosis, inhibited Bax expression but elevated Bcl-2 expression.	ursolic acid	47-49	BCL2, apoptosis regulator	Rattus norvegicus	287-292
34506233-4	2021	The results manifested that high- and low-dose UA reduced COM crystals in COM rats" kidney, down-regulated urea, creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) levels in rat plasma, declined kidney tissue and HK-2 cell apoptosis, inhibited Bax expression but elevated Bcl-2 expression.	ursolic acid	47-49	lipocalin 2	Rattus norvegicus	173-177
34506233-4	2021	The results manifested that high- and low-dose UA reduced COM crystals in COM rats" kidney, down-regulated urea, creatinine, and neutrophil gelatinase-associated lipocalin (NGAL) levels in rat plasma, declined kidney tissue and HK-2 cell apoptosis, inhibited Bax expression but elevated Bcl-2 expression.	ursolic acid	47-49	BCL2 associated X, apoptosis regulator	Rattus norvegicus	259-262
34737806-0	2021	Ursolic acid ameliorates adipose tissue insulin resistance in aged rats via activating the Akt-glucose transporter 4 signaling pathway and inhibiting inflammation.	ursolic acid	0-12	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
34737806-0	2021	Ursolic acid ameliorates adipose tissue insulin resistance in aged rats via activating the Akt-glucose transporter 4 signaling pathway and inhibiting inflammation.	ursolic acid	0-12	solute carrier family 2 member 4	Rattus norvegicus	95-116
34737806-10	2021	Conversely, UA inhibited the increase in NF-kappaB expression and proinflammatory cytokines IL-6 and IL-1beta.	ursolic acid	12-14	interleukin 6	Rattus norvegicus	92-96
34737806-10	2021	Conversely, UA inhibited the increase in NF-kappaB expression and proinflammatory cytokines IL-6 and IL-1beta.	ursolic acid	12-14	interleukin 1 alpha	Rattus norvegicus	101-109
34797663-1	2021	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.	ursolic acid	39-51	acyl-CoA synthetase medium chain family member 3	Homo sapiens	74-76
34569348-0	2021	Mitigation of ILbeta-1, ILbeta-6, TNF-alpha, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats.	ursolic acid	73-85	tumor necrosis factor	Rattus norvegicus	34-43
34569348-8	2021	Furthermore, CP-induced oxidative stress that was antagonized by UA-the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased.Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of ILbeta-1, ILbeta-6, TNF-alpha, and markers of apoptosis.	ursolic acid	65-67	catalase	Rattus norvegicus	96-99
34569348-8	2021	Furthermore, CP-induced oxidative stress that was antagonized by UA-the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased.Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of ILbeta-1, ILbeta-6, TNF-alpha, and markers of apoptosis.	ursolic acid	65-67	tumor necrosis factor	Rattus norvegicus	319-328
34569348-8	2021	Furthermore, CP-induced oxidative stress that was antagonized by UA-the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased.Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of ILbeta-1, ILbeta-6, TNF-alpha, and markers of apoptosis.	ursolic acid	174-176	catalase	Rattus norvegicus	96-99
34569348-8	2021	Furthermore, CP-induced oxidative stress that was antagonized by UA-the levels of GSH, SOD, and CAT were significantly increased while MDA content was decreased.Conclusions: UA has a protective effect against CP-induced nephrotoxicity, which may be due to its antioxidant activity and mitigation of ILbeta-1, ILbeta-6, TNF-alpha, and markers of apoptosis.	ursolic acid	174-176	tumor necrosis factor	Rattus norvegicus	319-328
34797663-1	2021	The aim of this study was to fabricate ursolic acid (UA)-sodium alginate (SA) complexes to improve the dissolution rate and antioxidant abilities.	ursolic acid	53-55	acyl-CoA synthetase medium chain family member 3	Homo sapiens	74-76
34677731-4	2021	Therefore, we screened different components of Tulsi leaf and found that eugenol, but not other major components (e.g. ursolic acid, oleanolic acid and beta-caryophylline), inhibited the interaction between spike S1 and ACE2 in an AlphaScreen-based assay.	ursolic acid	119-131	angiotensin converting enzyme 2	Homo sapiens	220-224
34942962-6	2021	Additionally, we discussed the phytochemicals like curcumin, quercetin, resveratrol, epigallocatechin gallate, apigenin, sulforaphane, and ursolic acid that have effectively modified NRF2 signaling and prevented various diseases in both in vitro and in vivo models.	ursolic acid	139-151	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
34584036-0	2021	The Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting the Wnt/beta-catenin Pathway.	ursolic acid	61-73	catenin beta 1	Homo sapiens	150-162
34584036-6	2021	We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels.	ursolic acid	14-26	catenin beta 1	Homo sapiens	115-127
34584036-6	2021	We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels.	ursolic acid	14-26	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	129-134
34584036-6	2021	We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular beta-catenin, c-myc, and cyclin D1 levels.	ursolic acid	14-26	cyclin D1	Homo sapiens	140-149
34584036-8	2021	These findings suggest that MRBE and its active ingredient, ursolic acid, exert antiproliferative activity by promoting the degradation of beta-catenin and may have significant chemopreventive potential against MM.	ursolic acid	60-72	catenin beta 1	Homo sapiens	139-151
34536821-0	2021	Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-kappaB signaling pathway.	ursolic acid	37-49	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
34560554-8	2021	Experimental studies displayed that UA up-regulated the decorin expression to activate IGF-IR signaling as well as to inhibit HIF-1 signaling, resulting in alleviation on metabolic dysfunction, liver steatosis, inflammation and hypoxia in high-fat-fed mice.	ursolic acid	36-38	insulin like growth factor 1 receptor	Homo sapiens	87-93
34536821-0	2021	Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-kappaB signaling pathway.	ursolic acid	37-49	nuclear factor kappa B subunit 1	Homo sapiens	99-108
34820315-7	2021	Antioxidant of ursolic acid was isolated from U. gambir with inhibitory concentration50 values 1721 +- 30.6 and 392 +- 53.57 mug/mL, respectively, against DPPH and SOD.	ursolic acid	15-27	superoxide dismutase 1	Homo sapiens	164-167
34768915-0	2021	Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade.	ursolic acid	0-12	AKT serine/threonine kinase 1	Homo sapiens	97-100
34768915-0	2021	Ursolic Acid Accelerates Paclitaxel-Induced Cell Death in Esophageal Cancer Cells by Suppressing Akt/FOXM1 Signaling Cascade.	ursolic acid	0-12	forkhead box M1	Homo sapiens	101-106
34768915-4	2021	Combination treatment with UA and PTX inhibited cell proliferation and cell growth more effectively than either treatment alone by inducing more significant apoptosis, as indicated by increased sub-G1 phase distribution and protein levels of cleaved-PARP and cleaved caspase-9.	ursolic acid	27-29	poly(ADP-ribose) polymerase 1	Homo sapiens	250-254
34768915-4	2021	Combination treatment with UA and PTX inhibited cell proliferation and cell growth more effectively than either treatment alone by inducing more significant apoptosis, as indicated by increased sub-G1 phase distribution and protein levels of cleaved-PARP and cleaved caspase-9.	ursolic acid	27-29	caspase 9	Homo sapiens	267-276
34768915-5	2021	Similar to the cell growth suppressive effect, the combination of UA and PTX significantly inhibited cell migration by targeting uPA, MMP-9, and E-cadherin in ESCC cells.	ursolic acid	66-68	proline rich acidic protein 1	Homo sapiens	129-132
34768915-5	2021	Similar to the cell growth suppressive effect, the combination of UA and PTX significantly inhibited cell migration by targeting uPA, MMP-9, and E-cadherin in ESCC cells.	ursolic acid	66-68	matrix metallopeptidase 9	Homo sapiens	134-139
34768915-5	2021	Similar to the cell growth suppressive effect, the combination of UA and PTX significantly inhibited cell migration by targeting uPA, MMP-9, and E-cadherin in ESCC cells.	ursolic acid	66-68	cadherin 1	Homo sapiens	145-155
34768915-6	2021	In addition, combination treatment with UA and PTX significantly activated p-GSK-3beta and suppressed the activation of Akt and FOXM1 in ESCC cells.	ursolic acid	40-42	glycogen synthase kinase 3 alpha	Homo sapiens	77-86
34768915-6	2021	In addition, combination treatment with UA and PTX significantly activated p-GSK-3beta and suppressed the activation of Akt and FOXM1 in ESCC cells.	ursolic acid	40-42	AKT serine/threonine kinase 1	Homo sapiens	120-123
34768915-6	2021	In addition, combination treatment with UA and PTX significantly activated p-GSK-3beta and suppressed the activation of Akt and FOXM1 in ESCC cells.	ursolic acid	40-42	forkhead box M1	Homo sapiens	128-133
34768915-9	2021	Thus, UA effectively potentiates the anti-tumor efficacy of PTX by targeting the Akt/FOXM1 cascade since combination treatment shows significantly more anti-tumor potential than PTX alone both in vitro and in vivo.	ursolic acid	6-8	AKT serine/threonine kinase 1	Homo sapiens	81-84
34768915-9	2021	Thus, UA effectively potentiates the anti-tumor efficacy of PTX by targeting the Akt/FOXM1 cascade since combination treatment shows significantly more anti-tumor potential than PTX alone both in vitro and in vivo.	ursolic acid	6-8	forkhead box M1	Homo sapiens	85-90
34790754-1	2021	Background: This article aims to explore whether ursolic acid (UA) inhibits the progression of retinoblastoma (Rb) by regulating stearoyl-CoA desaturase (SCD).	ursolic acid	49-61	stearoyl-CoA desaturase	Homo sapiens	129-152
34790754-1	2021	Background: This article aims to explore whether ursolic acid (UA) inhibits the progression of retinoblastoma (Rb) by regulating stearoyl-CoA desaturase (SCD).	ursolic acid	49-61	stearoyl-CoA desaturase	Homo sapiens	154-157
34790754-1	2021	Background: This article aims to explore whether ursolic acid (UA) inhibits the progression of retinoblastoma (Rb) by regulating stearoyl-CoA desaturase (SCD).	ursolic acid	63-65	stearoyl-CoA desaturase	Homo sapiens	129-152
34790754-1	2021	Background: This article aims to explore whether ursolic acid (UA) inhibits the progression of retinoblastoma (Rb) by regulating stearoyl-CoA desaturase (SCD).	ursolic acid	63-65	stearoyl-CoA desaturase	Homo sapiens	154-157
34790754-13	2021	Importantly, UA inhibited the proliferation, migration, and invasion of Rb cells through SCD inhibition.	ursolic acid	13-15	stearoyl-CoA desaturase	Homo sapiens	89-92
34790754-14	2021	Conclusions: UA inhibited the proliferation, migration, and invasion of Rb cells through SCD.	ursolic acid	13-15	stearoyl-CoA desaturase	Homo sapiens	89-92
34820315-0	2021	Action mode of ursolic acid as a natural antioxidant and inhibitor of superoxide dismutase: In vitro and in silico study.	ursolic acid	15-27	superoxide dismutase 1	Homo sapiens	70-90
34820315-8	2021	By in silico study presented that ursolic acid inhibited SOD enzyme with a binding affinity of - 5.4 kcal/mol those higher than a quercetin as a positive control.	ursolic acid	34-46	superoxide dismutase 1	Homo sapiens	57-60
34820315-9	2021	The ursolic acid was identified as a potential natural antioxidant with potentially activity to inhibit SOD mutant.	ursolic acid	4-16	superoxide dismutase 1	Homo sapiens	104-107
34393482-9	2021	The released UA drugs could notably inhibit the polarization of macrophages to pro-inflammatory macrophages (M1 type) and promote the expression of osteogenic-related genes (COL1, ALP and OPG) and osteogenic-related proteins (BMP-2, RUNX2 and COL1).	ursolic acid	13-15	ATHS	Homo sapiens	180-183
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	mitogen-activated protein kinase kinase 7	Homo sapiens	292-295
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	mitogen-activated protein kinase 1	Homo sapiens	296-299
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	AKT serine/threonine kinase 1	Homo sapiens	306-309
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	mechanistic target of rapamycin kinase	Homo sapiens	310-314
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	316-320
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	unc-51 like autophagy activating kinase 1	Homo sapiens	322-326
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	beclin 1	Homo sapiens	328-336
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	autophagy related 5	Homo sapiens	338-342
34512368-3	2021	In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53.	ursolic acid	151-163	tumor protein p53	Homo sapiens	347-350
34527135-0	2021	Erratum: Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.	ursolic acid	64-76	prominin 1	Homo sapiens	110-115
34186120-8	2021	Among the identified compounds, rosmarinic acid, caffeic acid, oleanolic acid, and ursolic acid showed high catalytic activity of alpha amylase and alpha-glucosidase.	ursolic acid	83-95	sucrase isomaltase (alpha-glucosidase)	Mus musculus	130-165
34393482-9	2021	The released UA drugs could notably inhibit the polarization of macrophages to pro-inflammatory macrophages (M1 type) and promote the expression of osteogenic-related genes (COL1, ALP and OPG) and osteogenic-related proteins (BMP-2, RUNX2 and COL1).	ursolic acid	13-15	basic transcription factor 3 pseudogene 11	Homo sapiens	188-191
34393482-9	2021	The released UA drugs could notably inhibit the polarization of macrophages to pro-inflammatory macrophages (M1 type) and promote the expression of osteogenic-related genes (COL1, ALP and OPG) and osteogenic-related proteins (BMP-2, RUNX2 and COL1).	ursolic acid	13-15	bone morphogenetic protein 2	Homo sapiens	226-231
34393482-9	2021	The released UA drugs could notably inhibit the polarization of macrophages to pro-inflammatory macrophages (M1 type) and promote the expression of osteogenic-related genes (COL1, ALP and OPG) and osteogenic-related proteins (BMP-2, RUNX2 and COL1).	ursolic acid	13-15	RUNX family transcription factor 2	Homo sapiens	233-238
34367967-5	2021	In addition, as a natural anticancer triterpene from various fruits and vegetables, ursolic acid (UA) treatment suppressed cell proliferation, down-regulated NUFIP1 protein expression, and further enhanced the effects of NUFIP1 knockdown in CRC cells in vitro.	ursolic acid	84-96	nuclear FMR1 interacting protein 1	Homo sapiens	158-164
34367967-5	2021	In addition, as a natural anticancer triterpene from various fruits and vegetables, ursolic acid (UA) treatment suppressed cell proliferation, down-regulated NUFIP1 protein expression, and further enhanced the effects of NUFIP1 knockdown in CRC cells in vitro.	ursolic acid	84-96	nuclear FMR1 interacting protein 1	Homo sapiens	221-227
34367967-5	2021	In addition, as a natural anticancer triterpene from various fruits and vegetables, ursolic acid (UA) treatment suppressed cell proliferation, down-regulated NUFIP1 protein expression, and further enhanced the effects of NUFIP1 knockdown in CRC cells in vitro.	ursolic acid	98-100	nuclear FMR1 interacting protein 1	Homo sapiens	158-164
34367967-5	2021	In addition, as a natural anticancer triterpene from various fruits and vegetables, ursolic acid (UA) treatment suppressed cell proliferation, down-regulated NUFIP1 protein expression, and further enhanced the effects of NUFIP1 knockdown in CRC cells in vitro.	ursolic acid	98-100	nuclear FMR1 interacting protein 1	Homo sapiens	221-227
34111615-0	2021	The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.	ursolic acid	17-29	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	120-125
34079975-7	2021	UA treatment significantly upregulated the expression of PR domain-containing 16 (PRDM16), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), and fibronectin type 3 domain-containing protein 5 (FNDC5) in GM and igSWAT.	ursolic acid	0-2	PR domain containing 16	Mus musculus	57-80
34079975-7	2021	UA treatment significantly upregulated the expression of PR domain-containing 16 (PRDM16), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), and fibronectin type 3 domain-containing protein 5 (FNDC5) in GM and igSWAT.	ursolic acid	0-2	PR domain containing 16	Mus musculus	82-88
34079975-7	2021	UA treatment significantly upregulated the expression of PR domain-containing 16 (PRDM16), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), and fibronectin type 3 domain-containing protein 5 (FNDC5) in GM and igSWAT.	ursolic acid	0-2	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	91-159
34079975-7	2021	UA treatment significantly upregulated the expression of PR domain-containing 16 (PRDM16), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), and fibronectin type 3 domain-containing protein 5 (FNDC5) in GM and igSWAT.	ursolic acid	0-2	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	161-171
34079975-7	2021	UA treatment significantly upregulated the expression of PR domain-containing 16 (PRDM16), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), and fibronectin type 3 domain-containing protein 5 (FNDC5) in GM and igSWAT.	ursolic acid	0-2	fibronectin type III domain containing 5	Mus musculus	226-231
34111615-0	2021	The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2.	ursolic acid	17-29	Peroxiredoxin prdx-2	Caenorhabditis elegans	130-135
34111615-6	2021	Skn-1 (which corresponds to human Nrf2) and prdx2 deficient mutants of the nematode Caenorhabditis elegans are suitable models to study the effect of UA on these targets.	ursolic acid	150-152	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	0-5
34111615-6	2021	Skn-1 (which corresponds to human Nrf2) and prdx2 deficient mutants of the nematode Caenorhabditis elegans are suitable models to study the effect of UA on these targets.	ursolic acid	150-152	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
34111615-9	2021	Additionally, we analyzed the binding of UA to human PRDX2 and Skn-1 proteins by molecular docking and microscale thermophoresis.	ursolic acid	41-43	peroxiredoxin 2	Homo sapiens	53-58
34111615-9	2021	Additionally, we analyzed the binding of UA to human PRDX2 and Skn-1 proteins by molecular docking and microscale thermophoresis.	ursolic acid	41-43	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	63-68
34111615-14	2021	CONCLUSION: Our findings implicate that the strong antioxidant activity of UA may exert anti-depressive effects by its interaction with the Skn-1 transcription factor, which is part of a detoxification network, and the antioxidant PRDX2 protein, which protects the organism from the detrimental effects of radical oxygen species.	ursolic acid	75-77	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	140-145
34111615-14	2021	CONCLUSION: Our findings implicate that the strong antioxidant activity of UA may exert anti-depressive effects by its interaction with the Skn-1 transcription factor, which is part of a detoxification network, and the antioxidant PRDX2 protein, which protects the organism from the detrimental effects of radical oxygen species.	ursolic acid	75-77	peroxiredoxin 2	Homo sapiens	231-236
34122127-11	2021	Besides, UA decreased serum DAO content, upregulated mRNA expression of ZO-1, claudin-1 and occludin and downregulated TNF-alpha and IL-6.	ursolic acid	9-11	amine oxidase, copper-containing 1	Mus musculus	28-31
34108504-3	2021	However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy.	ursolic acid	77-89	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	217-227
34108504-3	2021	However, nine dietary scaffolds, such as silibinin, flavopiridol, oleandrin, ursolic acid, alpha-boswellic acid, beta-boswellic acid, triterpenoid, guggulsterone, and oleanolic acid potentially bound to the cavity of PI3K-alpha, PKC-eta, H-Ras, and Ras with the highest binding energy.	ursolic acid	77-89	HRas proto-oncogene, GTPase	Homo sapiens	238-243
34122127-11	2021	Besides, UA decreased serum DAO content, upregulated mRNA expression of ZO-1, claudin-1 and occludin and downregulated TNF-alpha and IL-6.	ursolic acid	9-11	tight junction protein 1	Mus musculus	72-76
34122127-11	2021	Besides, UA decreased serum DAO content, upregulated mRNA expression of ZO-1, claudin-1 and occludin and downregulated TNF-alpha and IL-6.	ursolic acid	9-11	claudin 1	Mus musculus	78-87
34122127-11	2021	Besides, UA decreased serum DAO content, upregulated mRNA expression of ZO-1, claudin-1 and occludin and downregulated TNF-alpha and IL-6.	ursolic acid	9-11	occludin	Mus musculus	92-100
34122127-11	2021	Besides, UA decreased serum DAO content, upregulated mRNA expression of ZO-1, claudin-1 and occludin and downregulated TNF-alpha and IL-6.	ursolic acid	9-11	tumor necrosis factor	Mus musculus	119-128
34122127-11	2021	Besides, UA decreased serum DAO content, upregulated mRNA expression of ZO-1, claudin-1 and occludin and downregulated TNF-alpha and IL-6.	ursolic acid	9-11	interleukin 6	Mus musculus	133-137
34141150-5	2021	Ursolic acid was found to be a significant inhibitor of cancer cells migration and gene expression of migration markers FN1, CDH2, CTNNB1 and TWIST was also downregulated.	ursolic acid	0-12	fibronectin 1	Homo sapiens	120-123
34141150-5	2021	Ursolic acid was found to be a significant inhibitor of cancer cells migration and gene expression of migration markers FN1, CDH2, CTNNB1 and TWIST was also downregulated.	ursolic acid	0-12	cadherin 2	Homo sapiens	125-129
34141150-5	2021	Ursolic acid was found to be a significant inhibitor of cancer cells migration and gene expression of migration markers FN1, CDH2, CTNNB1 and TWIST was also downregulated.	ursolic acid	0-12	catenin beta 1	Homo sapiens	131-137
34141150-5	2021	Ursolic acid was found to be a significant inhibitor of cancer cells migration and gene expression of migration markers FN1, CDH2, CTNNB1 and TWIST was also downregulated.	ursolic acid	0-12	twist family bHLH transcription factor 1	Homo sapiens	142-147
34141150-6	2021	Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1, while upregulated the growth-restricting genes BAX, P21 and P53.	ursolic acid	0-12	BCL2 apoptosis regulator	Homo sapiens	77-82
34141150-6	2021	Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1, while upregulated the growth-restricting genes BAX, P21 and P53.	ursolic acid	0-12	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
34141150-6	2021	Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1, while upregulated the growth-restricting genes BAX, P21 and P53.	ursolic acid	0-12	H3 histone pseudogene 16	Homo sapiens	160-163
34141150-6	2021	Ursolic acid treatment downregulated the gene expression of survival factors BCL-2, SURVIVIN, NFKB and SP1, while upregulated the growth-restricting genes BAX, P21 and P53.	ursolic acid	0-12	tumor protein p53	Homo sapiens	168-171
34530693-0	2021	Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis.	ursolic acid	0-12	NADPH oxidase 4	Mus musculus	51-55
34528871-8	2021	In turn, the BrainDerived Neurotrophic Factor (BDNF) and Irisin levels showed an increase significant in the placebo and UA groups versus control.	ursolic acid	121-123	brain derived neurotrophic factor	Homo sapiens	13-45
34528871-8	2021	In turn, the BrainDerived Neurotrophic Factor (BDNF) and Irisin levels showed an increase significant in the placebo and UA groups versus control.	ursolic acid	121-123	brain derived neurotrophic factor	Homo sapiens	47-51
34528871-8	2021	In turn, the BrainDerived Neurotrophic Factor (BDNF) and Irisin levels showed an increase significant in the placebo and UA groups versus control.	ursolic acid	121-123	fibronectin type III domain containing 5	Homo sapiens	57-63
34348637-6	2021	Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha.	ursolic acid	39-51	interleukin 6	Homo sapiens	164-177
34348637-6	2021	Additionally, triterpene acid mixture (ursolic acid, oleanolic acid, and betulinic acid), also isolated from rosehip, has been reported to reduce the production of interleukin-6 and Tumor necrosis factor-alpha.	ursolic acid	39-51	tumor necrosis factor	Homo sapiens	182-209
34530693-6	2021	UA alleviated liver fibrosis, which manifested as decreases in collagen deposition, liver injury, and the expression of fibrosis-related factors, and the expression of NOX4 and NLRP3 was significantly inhibited by UA treatment.	ursolic acid	0-2	NADPH oxidase 4	Mus musculus	168-172
34530693-6	2021	UA alleviated liver fibrosis, which manifested as decreases in collagen deposition, liver injury, and the expression of fibrosis-related factors, and the expression of NOX4 and NLRP3 was significantly inhibited by UA treatment.	ursolic acid	0-2	NLR family, pyrin domain containing 3	Mus musculus	177-182
34530693-6	2021	UA alleviated liver fibrosis, which manifested as decreases in collagen deposition, liver injury, and the expression of fibrosis-related factors, and the expression of NOX4 and NLRP3 was significantly inhibited by UA treatment.	ursolic acid	214-216	NADPH oxidase 4	Mus musculus	168-172
34530693-6	2021	UA alleviated liver fibrosis, which manifested as decreases in collagen deposition, liver injury, and the expression of fibrosis-related factors, and the expression of NOX4 and NLRP3 was significantly inhibited by UA treatment.	ursolic acid	214-216	NLR family, pyrin domain containing 3	Mus musculus	177-182
34530693-0	2021	Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis.	ursolic acid	0-12	NLR family, pyrin domain containing 3	Mus musculus	56-61
34530693-3	2021	This study aimed to explore whether the effect of ursolic acid (UA) on liver fibrosis was associated with the NOX4/NLRP3 inflammasome pathways and intestinal bacteria.	ursolic acid	50-62	NADPH oxidase 4	Mus musculus	110-114
34530693-3	2021	This study aimed to explore whether the effect of ursolic acid (UA) on liver fibrosis was associated with the NOX4/NLRP3 inflammasome pathways and intestinal bacteria.	ursolic acid	50-62	NLR family, pyrin domain containing 3	Mus musculus	115-120
34530693-3	2021	This study aimed to explore whether the effect of ursolic acid (UA) on liver fibrosis was associated with the NOX4/NLRP3 inflammasome pathways and intestinal bacteria.	ursolic acid	64-66	NADPH oxidase 4	Mus musculus	110-114
34530693-3	2021	This study aimed to explore whether the effect of ursolic acid (UA) on liver fibrosis was associated with the NOX4/NLRP3 inflammasome pathways and intestinal bacteria.	ursolic acid	64-66	NLR family, pyrin domain containing 3	Mus musculus	115-120
35548957-0	2022	Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression.	ursolic acid	0-12	signal transducer and activator of transcription 3	Rattus norvegicus	52-57
35548957-0	2022	Ursolic acid inhibits Th17 cell differentiation via STAT3/RORgammat pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression.	ursolic acid	0-12	C-X-C motif chemokine ligand 9	Rattus norvegicus	145-153
35548957-4	2022	Naive CD4+ T cells were isolated from rat peripheral blood, induced for Th17 cell differentiation, and treated with UA.	ursolic acid	116-118	Cd4 molecule	Rattus norvegicus	6-9
35548957-9	2022	UA inhibited the Th17 cell differentiation and suppressed the STAT3/RORgammat pathway.	ursolic acid	0-2	signal transducer and activator of transcription 3	Rattus norvegicus	62-67
35548957-10	2022	STAT3 overexpression up-regulated p-STAT3 and RORgammat expression and promoted Th17 cell differentiation under the UA treatment.	ursolic acid	116-118	signal transducer and activator of transcription 3	Rattus norvegicus	0-5
35548957-14	2022	UA inhibited Th17 cell differentiation through STAT3/RORgammat pathway and suppressed Th17 cell migration through down-regulating CXCL9/10 expression in SCs.	ursolic acid	0-2	signal transducer and activator of transcription 3	Rattus norvegicus	47-52
35548957-14	2022	UA inhibited Th17 cell differentiation through STAT3/RORgammat pathway and suppressed Th17 cell migration through down-regulating CXCL9/10 expression in SCs.	ursolic acid	0-2	C-X-C motif chemokine ligand 9	Rattus norvegicus	130-138
35571705-8	2022	Western blot assay was used to detect the expression level of autophagic protein P62 at different time points of ursolic acid on 786-O.	ursolic acid	113-125	nucleoporin 62	Homo sapiens	81-84
35218459-7	2022	URO (6 mg/kg) and donepezil reversed the OBX-induced down-regulation of vascular endothelial growth factor (VEGF) and choline acetyltransferase expression levels in the hippocampus.	ursolic acid	0-3	vascular endothelial growth factor A	Mus musculus	72-106
35218459-7	2022	URO (6 mg/kg) and donepezil reversed the OBX-induced down-regulation of vascular endothelial growth factor (VEGF) and choline acetyltransferase expression levels in the hippocampus.	ursolic acid	0-3	vascular endothelial growth factor A	Mus musculus	108-112
35218459-11	2022	The effects of URO are, at least in part, mediated by normalizing the function of central cholinergic systems and VEGF protein expression.	ursolic acid	15-18	vascular endothelial growth factor A	Mus musculus	114-118
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	ursolic acid	28-40	intercellular adhesion molecule 1	Homo sapiens	142-175
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	ursolic acid	28-40	intercellular adhesion molecule 1	Homo sapiens	177-183
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	ursolic acid	28-40	TNF receptor superfamily member 8	Homo sapiens	262-270
35630550-2	2022	We previously reported that ursolic acid, corosolic acid, and asiatic acid interfered with the intracellular trafficking and glycosylation of intercellular adhesion molecule-1 (ICAM-1) in human lung adenocarcinoma A549 cells stimulated with the pro-inflammatory cytokine interleukin-1alpha.	ursolic acid	28-40	interleukin 1 alpha	Homo sapiens	271-289
35593021-3	2022	Also, the impact of ursolic acid, as a potent inducer of the Trp53 protein in ameliorating decreased muscle mass, was analyzed in diabetic rats.	ursolic acid	20-32	tumor protein p53	Rattus norvegicus	61-66
35593021-7	2022	In addition, the results demonstrated that exercise and supplementation of UA impeded the interactions among p53/ATF4/p21.	ursolic acid	75-77	tumor protein p53	Rattus norvegicus	109-112
35593021-7	2022	In addition, the results demonstrated that exercise and supplementation of UA impeded the interactions among p53/ATF4/p21.	ursolic acid	75-77	activating transcription factor 4	Rattus norvegicus	113-117
35593021-7	2022	In addition, the results demonstrated that exercise and supplementation of UA impeded the interactions among p53/ATF4/p21.	ursolic acid	75-77	KRAS proto-oncogene, GTPase	Rattus norvegicus	118-121
35593021-8	2022	Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway.	ursolic acid	17-29	tumor protein p53	Rattus norvegicus	82-85
35593021-8	2022	Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway.	ursolic acid	17-29	activating transcription factor 4	Rattus norvegicus	86-90
35593021-8	2022	Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway.	ursolic acid	17-29	KRAS proto-oncogene, GTPase	Rattus norvegicus	91-94
35593021-8	2022	Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway.	ursolic acid	17-29	tumor protein p53	Rattus norvegicus	157-160
35593021-8	2022	Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway.	ursolic acid	17-29	activating transcription factor 4	Rattus norvegicus	161-165
35593021-8	2022	Moreover, ET and ursolic acid had a synergetic effect on the signaling pathway of p53/ATF4/p21 and probably could inhibit the aging process and modulate the p53/ATF4/p21 molecular pathway.	ursolic acid	17-29	KRAS proto-oncogene, GTPase	Rattus norvegicus	166-169
35593021-9	2022	The interaction between UA and endurance exercise significantly modified the activity of the p53/ATF4/p21 signaling pathway.	ursolic acid	24-26	tumor protein p53	Rattus norvegicus	93-96
35593021-9	2022	The interaction between UA and endurance exercise significantly modified the activity of the p53/ATF4/p21 signaling pathway.	ursolic acid	24-26	activating transcription factor 4	Rattus norvegicus	97-101
35593021-9	2022	The interaction between UA and endurance exercise significantly modified the activity of the p53/ATF4/p21 signaling pathway.	ursolic acid	24-26	KRAS proto-oncogene, GTPase	Rattus norvegicus	102-105
35509047-8	2022	CONCLUSIONS: Ursolic acid-enriched KDCE enhances the antitumor activity of BCI, which could be mediated by VEGFR2 downregulation and subsequent suppression of angiogenesis.	ursolic acid	13-25	kinase insert domain protein receptor	Mus musculus	107-113
35571705-10	2022	Further, AdPlus-mCherry-GFP-LC3B adenovirus transfection was used to detect the effect of ursolic acid on the autophagic flow of 786-O cells; ursolic acid was combined with the autophagy inhibitor chloroquine (CQ) to detect the expression level of autophagy protein LC3II by Western blot.	ursolic acid	90-102	microtubule associated protein 1 light chain 3 beta	Homo sapiens	28-32
35571705-12	2022	Results: Ursolic acid inhibited the activity, proliferation, and migration of 786-O cells, enhanced the fluorescence intensity of autophagosomes in 786-O cells, increased the expression level of autophagy marker protein LC3II, and inhibited the expression level of P62 in a time and dose-dependent manner; ursolic acid activated the autophagic flow in 786-O cells, which showed that ursolic acid caused the accumulation of autophagic fluorescent spots and enhanced the fluorescence intensity of autophagosomes.	ursolic acid	9-21	nucleoporin 62	Homo sapiens	265-268
35571705-13	2022	Ursolic acid activated the autophagic flow in 786-O cells, as evidenced by the accumulation of autophagic fluorescent spots and enhanced fluorescence intensity of autophagosomes, and the combined use of the autophagy inhibitor CQ increased the expression level of LC3II compared to ursolic acid alone; ursolic acid decreased the expression levels of PTCH1, GLI1, SMO, SHH, and c-Myc and increased the expression level of Sufu in the hedgehog signaling pathway.	ursolic acid	0-12	patched 1	Homo sapiens	350-355
35571705-13	2022	Ursolic acid activated the autophagic flow in 786-O cells, as evidenced by the accumulation of autophagic fluorescent spots and enhanced fluorescence intensity of autophagosomes, and the combined use of the autophagy inhibitor CQ increased the expression level of LC3II compared to ursolic acid alone; ursolic acid decreased the expression levels of PTCH1, GLI1, SMO, SHH, and c-Myc and increased the expression level of Sufu in the hedgehog signaling pathway.	ursolic acid	0-12	GLI family zinc finger 1	Homo sapiens	357-361
35571705-13	2022	Ursolic acid activated the autophagic flow in 786-O cells, as evidenced by the accumulation of autophagic fluorescent spots and enhanced fluorescence intensity of autophagosomes, and the combined use of the autophagy inhibitor CQ increased the expression level of LC3II compared to ursolic acid alone; ursolic acid decreased the expression levels of PTCH1, GLI1, SMO, SHH, and c-Myc and increased the expression level of Sufu in the hedgehog signaling pathway.	ursolic acid	0-12	smoothened, frizzled class receptor	Homo sapiens	363-366
35571705-13	2022	Ursolic acid activated the autophagic flow in 786-O cells, as evidenced by the accumulation of autophagic fluorescent spots and enhanced fluorescence intensity of autophagosomes, and the combined use of the autophagy inhibitor CQ increased the expression level of LC3II compared to ursolic acid alone; ursolic acid decreased the expression levels of PTCH1, GLI1, SMO, SHH, and c-Myc and increased the expression level of Sufu in the hedgehog signaling pathway.	ursolic acid	0-12	sonic hedgehog signaling molecule	Homo sapiens	368-371
35571705-13	2022	Ursolic acid activated the autophagic flow in 786-O cells, as evidenced by the accumulation of autophagic fluorescent spots and enhanced fluorescence intensity of autophagosomes, and the combined use of the autophagy inhibitor CQ increased the expression level of LC3II compared to ursolic acid alone; ursolic acid decreased the expression levels of PTCH1, GLI1, SMO, SHH, and c-Myc and increased the expression level of Sufu in the hedgehog signaling pathway.	ursolic acid	0-12	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	377-382
35571705-13	2022	Ursolic acid activated the autophagic flow in 786-O cells, as evidenced by the accumulation of autophagic fluorescent spots and enhanced fluorescence intensity of autophagosomes, and the combined use of the autophagy inhibitor CQ increased the expression level of LC3II compared to ursolic acid alone; ursolic acid decreased the expression levels of PTCH1, GLI1, SMO, SHH, and c-Myc and increased the expression level of Sufu in the hedgehog signaling pathway.	ursolic acid	0-12	SUFU negative regulator of hedgehog signaling	Homo sapiens	421-425
35392531-11	2022	CONCLUSIONS: Our results indicated that UA improves the IS-induced impairment of mitochondrial biogenesis by affecting differentiation, ATP levels, and IL-6 secretion in C2C12 cells.	ursolic acid	40-42	interleukin 6	Mus musculus	152-156
35034940-10	2022	Ursolic-acid-treated rats have been shown to decrease oxidative stress in pancreatic tissue by restoring the free radical effect of scavenging, suppress the Traf-6, Mapk-8 and Traf-4 mRNA expression, enhance the expression of Pdx-1, Ins-1 and Ngn-3 and ensure the regeneration of pancreas beta cells and therefore pancreas insulin.	ursolic acid	0-12	TNF receptor associated factor 6	Rattus norvegicus	157-163
35204308-7	2022	In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway.	ursolic acid	15-17	basket	Drosophila melanogaster	81-84
35204308-7	2022	In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway.	ursolic acid	15-17	hopscotch	Drosophila melanogaster	85-88
35204308-0	2022	Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling.	ursolic acid	0-12	basket	Drosophila melanogaster	107-110
35204308-5	2022	Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT).	ursolic acid	9-11	Catalase	Drosophila melanogaster	187-195
35204308-5	2022	Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT).	ursolic acid	9-11	Catalase	Drosophila melanogaster	197-200
35222644-10	2022	Examination of cell death importation showed that the UA formed the expression of the iNOS and thus the cell generation and mitochondrial reactive oxygen generation, which created a reaction to cellular DNA damage by raising the protein levels of phospho-histone ATR and ATM.	ursolic acid	54-56	inositol-3-phosphate synthase 1	Homo sapiens	86-90
35222644-10	2022	Examination of cell death importation showed that the UA formed the expression of the iNOS and thus the cell generation and mitochondrial reactive oxygen generation, which created a reaction to cellular DNA damage by raising the protein levels of phospho-histone ATR and ATM.	ursolic acid	54-56	ATM serine/threonine kinase	Homo sapiens	271-274
35209071-6	2022	The obtained results showed that UA significantly inhibited the adhesion and migration of MCF-7/ADR cells, and had higher affinities with key active cavity residues of ODC compared to the known inhibitor di-fluoro-methyl-ornithine (DFMO).	ursolic acid	33-35	ornithine decarboxylase 1	Homo sapiens	168-171
35209071-10	2022	Taken together, UA can inhibit against tumor progression during the treatment of breast cancer with Dox, and possibly modulate the Erk-VEGF/MMP-9 signaling pathways and polyamine metabolism by targeting ODC to exert these effects.	ursolic acid	16-18	mitogen-activated protein kinase 1	Homo sapiens	131-134
35209071-10	2022	Taken together, UA can inhibit against tumor progression during the treatment of breast cancer with Dox, and possibly modulate the Erk-VEGF/MMP-9 signaling pathways and polyamine metabolism by targeting ODC to exert these effects.	ursolic acid	16-18	vascular endothelial growth factor A	Homo sapiens	135-139
35209071-10	2022	Taken together, UA can inhibit against tumor progression during the treatment of breast cancer with Dox, and possibly modulate the Erk-VEGF/MMP-9 signaling pathways and polyamine metabolism by targeting ODC to exert these effects.	ursolic acid	16-18	matrix metallopeptidase 9	Homo sapiens	140-145
35209071-10	2022	Taken together, UA can inhibit against tumor progression during the treatment of breast cancer with Dox, and possibly modulate the Erk-VEGF/MMP-9 signaling pathways and polyamine metabolism by targeting ODC to exert these effects.	ursolic acid	16-18	ornithine decarboxylase 1	Homo sapiens	203-206
35034940-10	2022	Ursolic-acid-treated rats have been shown to decrease oxidative stress in pancreatic tissue by restoring the free radical effect of scavenging, suppress the Traf-6, Mapk-8 and Traf-4 mRNA expression, enhance the expression of Pdx-1, Ins-1 and Ngn-3 and ensure the regeneration of pancreas beta cells and therefore pancreas insulin.	ursolic acid	0-12	mitogen-activated protein kinase 8	Rattus norvegicus	165-171
35034940-10	2022	Ursolic-acid-treated rats have been shown to decrease oxidative stress in pancreatic tissue by restoring the free radical effect of scavenging, suppress the Traf-6, Mapk-8 and Traf-4 mRNA expression, enhance the expression of Pdx-1, Ins-1 and Ngn-3 and ensure the regeneration of pancreas beta cells and therefore pancreas insulin.	ursolic acid	0-12	Tnf receptor associated factor 4	Rattus norvegicus	176-182
35034940-10	2022	Ursolic-acid-treated rats have been shown to decrease oxidative stress in pancreatic tissue by restoring the free radical effect of scavenging, suppress the Traf-6, Mapk-8 and Traf-4 mRNA expression, enhance the expression of Pdx-1, Ins-1 and Ngn-3 and ensure the regeneration of pancreas beta cells and therefore pancreas insulin.	ursolic acid	0-12	pancreatic and duodenal homeobox 1	Rattus norvegicus	226-231
35034940-10	2022	Ursolic-acid-treated rats have been shown to decrease oxidative stress in pancreatic tissue by restoring the free radical effect of scavenging, suppress the Traf-6, Mapk-8 and Traf-4 mRNA expression, enhance the expression of Pdx-1, Ins-1 and Ngn-3 and ensure the regeneration of pancreas beta cells and therefore pancreas insulin.	ursolic acid	0-12	insulin 1	Rattus norvegicus	233-238
35034940-10	2022	Ursolic-acid-treated rats have been shown to decrease oxidative stress in pancreatic tissue by restoring the free radical effect of scavenging, suppress the Traf-6, Mapk-8 and Traf-4 mRNA expression, enhance the expression of Pdx-1, Ins-1 and Ngn-3 and ensure the regeneration of pancreas beta cells and therefore pancreas insulin.	ursolic acid	0-12	neurogenin 3	Rattus norvegicus	243-248
35034940-11	2022	The current result suggested the anti-obese effect of ursolic acid against high fat diet (HFD) induced obese rats via alteration of insulin and JNK signaling pathway.	ursolic acid	54-66	mitogen-activated protein kinase 8	Rattus norvegicus	144-147
34791376-0	2022	Role of heme oxygenase-1 in the antidepressant-like effect of ursolic acid in the tail suspension test.	ursolic acid	62-74	heme oxygenase 1	Mus musculus	8-24
34791376-1	2022	OBJECTIVES: This study investigated the involvement of heme oxygenase-1 (HO-1) in the antidepressant-like effects of ursolic acid (UA), a plant-derived compound with neuroprotective and antidepressant-like properties.	ursolic acid	117-129	heme oxygenase 1	Mus musculus	73-77
34791376-1	2022	OBJECTIVES: This study investigated the involvement of heme oxygenase-1 (HO-1) in the antidepressant-like effects of ursolic acid (UA), a plant-derived compound with neuroprotective and antidepressant-like properties.	ursolic acid	131-133	heme oxygenase 1	Mus musculus	73-77
34791376-9	2022	Acute administration of UA or CoPP, but not fluoxetine, increased the HO-1 immunocontent in the hippocampus.	ursolic acid	24-26	heme oxygenase 1	Mus musculus	70-74
34791376-11	2022	CONCLUSIONS: In conclusion, this work shows that increased hippocampal HO-1 content and activity mediate the antidepressant-like effect of UA in the TST.	ursolic acid	139-141	heme oxygenase 1	Mus musculus	71-75
35438581-0	2022	Ursolic acid protects against anoxic injury in cardiac microvascular endothelial cells by regulating intercellular adhesion molecule-1 and toll-like receptor 4/MyD88/NF-kappaB pathway.	ursolic acid	0-12	intercellular adhesion molecule 1	Homo sapiens	101-134
35438581-0	2022	Ursolic acid protects against anoxic injury in cardiac microvascular endothelial cells by regulating intercellular adhesion molecule-1 and toll-like receptor 4/MyD88/NF-kappaB pathway.	ursolic acid	0-12	toll like receptor 4	Homo sapiens	139-159
35438581-0	2022	Ursolic acid protects against anoxic injury in cardiac microvascular endothelial cells by regulating intercellular adhesion molecule-1 and toll-like receptor 4/MyD88/NF-kappaB pathway.	ursolic acid	0-12	MYD88 innate immune signal transduction adaptor	Homo sapiens	160-165
35438581-0	2022	Ursolic acid protects against anoxic injury in cardiac microvascular endothelial cells by regulating intercellular adhesion molecule-1 and toll-like receptor 4/MyD88/NF-kappaB pathway.	ursolic acid	0-12	nuclear factor kappa B subunit 1	Homo sapiens	166-175
35438581-7	2022	UA treatment obviously reversed these H/R-induced injuries and reduced ICAM1 expression.	ursolic acid	0-2	intercellular adhesion molecule 1	Homo sapiens	71-76
35438581-8	2022	Moreover, knockdown of ICAM1 could alleviate the H/R-induced injuries and strengthen the protective effect of UA on CMECs under H/R condition.	ursolic acid	110-112	intercellular adhesion molecule 1	Homo sapiens	23-28
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	ursolic acid	41-43	intercellular adhesion molecule 1	Homo sapiens	104-109
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	ursolic acid	41-43	toll like receptor 4	Homo sapiens	114-118
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	ursolic acid	41-43	MYD88 innate immune signal transduction adaptor	Homo sapiens	119-124
35438581-10	2022	CONCLUSIONS: Our results insinuated that UA could alleviate H/R-induced injuries in CMECs by regulating ICAM1 and TLR4/MyD88/NF-kappaB pathway.	ursolic acid	41-43	nuclear factor kappa B subunit 1	Homo sapiens	125-134