PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34055057-8	2021	Of note, hirsutanol A induced the expression of the tumor suppressor p53, whereas simultaneous treatment with pifithrin-alpha, an inhibitor of p53, significantly reduced Jurkat cell apoptosis induced by hirsutanol A.	pifithrin	110-125	tumor protein p53	Homo sapiens	143-146
32940875-8	2021	Importantly, TUNEL and CCK-8 assays both demonstrated that treatment with p53 antagonist pifithrin-alpha (PFT-alpha) markedly attenuated TPEN-induced OEC apoptosis.	pifithrin	89-104	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	74-77
33945996-8	2021	Additionally, the expression of these proteins can be reversed by the use of pifithrin-alpha (PFT-alpha), a p53 inhibitor.	pifithrin	77-92	tumor protein p53	Homo sapiens	108-111
33945996-8	2021	Additionally, the expression of these proteins can be reversed by the use of pifithrin-alpha (PFT-alpha), a p53 inhibitor.	pifithrin	94-103	tumor protein p53	Homo sapiens	108-111
33852931-5	2021	Abeta25-35-induced sestrin2 expression was abolished by the p65 siRNA, the NF-kappaB inhibitor SN50, and the p53 inhibitor pifithrin-alpha (PFT-alpha).	pifithrin	123-138	sestrin 2	Rattus norvegicus	19-27
33852931-5	2021	Abeta25-35-induced sestrin2 expression was abolished by the p65 siRNA, the NF-kappaB inhibitor SN50, and the p53 inhibitor pifithrin-alpha (PFT-alpha).	pifithrin	123-138	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	109-112
33852931-5	2021	Abeta25-35-induced sestrin2 expression was abolished by the p65 siRNA, the NF-kappaB inhibitor SN50, and the p53 inhibitor pifithrin-alpha (PFT-alpha).	pifithrin	140-149	sestrin 2	Rattus norvegicus	19-27
33827945-5	2021	Different from memory-like NK cells reported previously, these NKp46+NKG2A+ memory NK cells exhibited HA-specific silence of cytotoxicity but increase of IFN-gamma response against influenza virus-infected cells, which could be reversed by Pifithrin-mu, a p53-HSP70 signaling inhibitor.	pifithrin	240-249	natural cytotoxicity triggering receptor 1	Homo sapiens	63-68
33827945-5	2021	Different from memory-like NK cells reported previously, these NKp46+NKG2A+ memory NK cells exhibited HA-specific silence of cytotoxicity but increase of IFN-gamma response against influenza virus-infected cells, which could be reversed by Pifithrin-mu, a p53-HSP70 signaling inhibitor.	pifithrin	240-249	killer cell lectin like receptor C1	Homo sapiens	69-74
33877544-12	2021	BOP1 silencing-induced suppression of cell proliferation was partly reversed by pifithrin-alpha (a p53 inhibitor).	pifithrin	80-95	BOP1 ribosomal biogenesis factor	Homo sapiens	0-4
33877544-12	2021	BOP1 silencing-induced suppression of cell proliferation was partly reversed by pifithrin-alpha (a p53 inhibitor).	pifithrin	80-95	tumor protein p53	Homo sapiens	99-102
32940875-8	2021	Importantly, TUNEL and CCK-8 assays both demonstrated that treatment with p53 antagonist pifithrin-alpha (PFT-alpha) markedly attenuated TPEN-induced OEC apoptosis.	pifithrin	106-115	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	74-77
33162236-8	2021	The inhibition of p53 by pifithrin-alpha significantly reduced MEHP-induced injuries in TM3 cells.	pifithrin	25-40	transformation related protein 53, pseudogene	Mus musculus	18-21
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	88-103	ribosomal protein L11	Homo sapiens	10-31
33754023-13	2021	Pifithrin-alpha alleviated cardiac aging and enhanced fatty acid metabolism in the aged Rap1-/- mice.	pifithrin	0-15	RAS-related protein 1a	Mus musculus	88-92
33302638-10	2021	Besides, the ligustrazine-induced cell apoptosis and cell cycle arrest were markedly reversed by pifithrin-alpha (p53 inhibitor), which suggested that ligustrazine-induced cell apoptosis was achieved by regulating p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase.	pifithrin	97-112	transformation related protein 53, pseudogene	Mus musculus	114-117
33302638-10	2021	Besides, the ligustrazine-induced cell apoptosis and cell cycle arrest were markedly reversed by pifithrin-alpha (p53 inhibitor), which suggested that ligustrazine-induced cell apoptosis was achieved by regulating p53-dependent mitochondrial pathway and cell cycle arrest at the G0/G1 phase.	pifithrin	97-112	transformation related protein 53, pseudogene	Mus musculus	214-217
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	88-103	ribosomal protein L11	Homo sapiens	33-38
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	88-103	tumor protein p53	Homo sapiens	81-84
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	88-103	BOP1 ribosomal biogenesis factor	Rattus norvegicus	166-170
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	105-114	ribosomal protein L11	Homo sapiens	10-31
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	105-114	ribosomal protein L11	Homo sapiens	33-38
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	105-114	tumor protein p53	Homo sapiens	81-84
33510838-7	2021	Knockdown ribosomal protein L11 (RPL11) by transfecting with siRNA or inhibiting p53 by pifithrin-alpha (PFT-alpha) partly reserved the biological effects induced by BOP1 knockdown.	pifithrin	105-114	BOP1 ribosomal biogenesis factor	Rattus norvegicus	166-170
33274012-9	2020	Importantly, we further confirmed the p53-mediated HMGCR axis activation by using pifithrin-alpha (PFT) in SH-SY5Y cells.	pifithrin	82-97	tumor protein p53	Sus scrofa	38-41
32590695-8	2021	The P53 inhibitor Pifithrin-mu reduced apoptosis induced by P53 mitochondrial translocation.	pifithrin	18-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
32590695-8	2021	The P53 inhibitor Pifithrin-mu reduced apoptosis induced by P53 mitochondrial translocation.	pifithrin	18-27	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	60-63
33835030-4	2021	PES (2-phenylethynesulfonamide or pifithrin-mu) has been reported to be an inhibitor of Hsp70.	pifithrin	34-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93
31886905-5	2020	Western blot was used to measure the levels of p53 and its acetylated versions in cells treated with carboplatin and/or pifithrin-alpha.	pifithrin	120-135	tumor protein p53	Homo sapiens	47-50
33299335-5	2020	Results: Overexpression of p53 stimulated, while inhibition of p53 by pifithrin-alpha significantly suppressed the GnRH secretion and GPR54 expression levels in response to kisspeptin stimulation in GT1-7 cells.	pifithrin	70-85	transformation related protein 53, pseudogene	Mus musculus	63-66
33299335-5	2020	Results: Overexpression of p53 stimulated, while inhibition of p53 by pifithrin-alpha significantly suppressed the GnRH secretion and GPR54 expression levels in response to kisspeptin stimulation in GT1-7 cells.	pifithrin	70-85	gonadotropin releasing hormone 1	Mus musculus	115-119
33299335-5	2020	Results: Overexpression of p53 stimulated, while inhibition of p53 by pifithrin-alpha significantly suppressed the GnRH secretion and GPR54 expression levels in response to kisspeptin stimulation in GT1-7 cells.	pifithrin	70-85	KISS1 receptor	Mus musculus	134-139
33299335-5	2020	Results: Overexpression of p53 stimulated, while inhibition of p53 by pifithrin-alpha significantly suppressed the GnRH secretion and GPR54 expression levels in response to kisspeptin stimulation in GT1-7 cells.	pifithrin	70-85	KiSS-1 metastasis-suppressor	Mus musculus	173-183
33299335-5	2020	Results: Overexpression of p53 stimulated, while inhibition of p53 by pifithrin-alpha significantly suppressed the GnRH secretion and GPR54 expression levels in response to kisspeptin stimulation in GT1-7 cells.	pifithrin	70-85	guanine nucleotide binding protein, alpha transducing 2	Mus musculus	199-204
33274012-9	2020	Importantly, we further confirmed the p53-mediated HMGCR axis activation by using pifithrin-alpha (PFT) in SH-SY5Y cells.	pifithrin	82-97	3-hydroxy-3-methylglutaryl-CoA reductase	Sus scrofa	51-56
32901866-6	2020	Furthermore, the p53 inhibitor, Pifithrin-mu, diminished the augmentation in poly(ADP-ribose) polymerase (PARP) cleavage induced by OTS514 plus H2O2, while the Mdm2 antagonist, Nutlin 3, increased PARP cleavage.	pifithrin	32-41	tumor protein p53	Homo sapiens	17-20
32901866-6	2020	Furthermore, the p53 inhibitor, Pifithrin-mu, diminished the augmentation in poly(ADP-ribose) polymerase (PARP) cleavage induced by OTS514 plus H2O2, while the Mdm2 antagonist, Nutlin 3, increased PARP cleavage.	pifithrin	32-41	poly(ADP-ribose) polymerase 1	Homo sapiens	77-104
32901866-6	2020	Furthermore, the p53 inhibitor, Pifithrin-mu, diminished the augmentation in poly(ADP-ribose) polymerase (PARP) cleavage induced by OTS514 plus H2O2, while the Mdm2 antagonist, Nutlin 3, increased PARP cleavage.	pifithrin	32-41	poly(ADP-ribose) polymerase 1	Homo sapiens	106-110
32901866-6	2020	Furthermore, the p53 inhibitor, Pifithrin-mu, diminished the augmentation in poly(ADP-ribose) polymerase (PARP) cleavage induced by OTS514 plus H2O2, while the Mdm2 antagonist, Nutlin 3, increased PARP cleavage.	pifithrin	32-41	MDM2 proto-oncogene	Homo sapiens	160-164
32901866-6	2020	Furthermore, the p53 inhibitor, Pifithrin-mu, diminished the augmentation in poly(ADP-ribose) polymerase (PARP) cleavage induced by OTS514 plus H2O2, while the Mdm2 antagonist, Nutlin 3, increased PARP cleavage.	pifithrin	32-41	poly(ADP-ribose) polymerase 1	Homo sapiens	197-201
32945383-13	2020	Pifithrin-alpha, an inhibitor of p53, partially reduced RSV-induced apoptosis and autophagy.	pifithrin	0-15	tumor protein p53	Homo sapiens	33-36
32898154-8	2020	Accordingly, in utero treatment of TashT embryos with the p53 inhibitor pifithrin-alpha decreased Ddx3y expression and abolished the otherwise more severe ENS defect in TashT males.	pifithrin	72-87	tumor protein p53	Homo sapiens	58-61
32978368-8	2020	Importantly, the antioxidant N-acetyl-cysteine and the p53 inhibitor pifithrin-alpha attenuated A1874-induced cell death and apoptosis in colon cancer cells.	pifithrin	69-84	tumor protein p53	Homo sapiens	55-58
32898154-8	2020	Accordingly, in utero treatment of TashT embryos with the p53 inhibitor pifithrin-alpha decreased Ddx3y expression and abolished the otherwise more severe ENS defect in TashT males.	pifithrin	72-87	DEAD-box helicase 3 Y-linked	Homo sapiens	98-103
32741018-10	2020	Gene expression profiling results identified p53 pathway as a key downstream target of Rig-G, and p53 inhibition by pifithrin-alpha caused abrogation of tumor-suppressive effects of Rig-G in lung cancer.	pifithrin	116-131	transformation related protein 53, pseudogene	Mus musculus	98-101
32687844-10	2020	DpdtC treatment resulted in upregulation of p53, but, the addition of p53 inhibitor, PFT-alpha could significantly neutralize the action of DpdtC on ferritinophagy induction and EMT inhibition.	pifithrin	85-94	tumor protein p53	Homo sapiens	70-73
32741018-10	2020	Gene expression profiling results identified p53 pathway as a key downstream target of Rig-G, and p53 inhibition by pifithrin-alpha caused abrogation of tumor-suppressive effects of Rig-G in lung cancer.	pifithrin	116-131	interferon induced protein with tetratricopeptide repeats 3	Homo sapiens	182-187
32922194-10	2020	Inhibition of p53 by pifithrin-alpha significantly reduced the levels of PUMA, Bax, and PTEN but restored AKT phosphorylation in SiHa cells exposed to sesamin.	pifithrin	21-36	tumor protein p53	Homo sapiens	14-17
32922194-10	2020	Inhibition of p53 by pifithrin-alpha significantly reduced the levels of PUMA, Bax, and PTEN but restored AKT phosphorylation in SiHa cells exposed to sesamin.	pifithrin	21-36	BCL2 binding component 3	Homo sapiens	73-77
32922194-10	2020	Inhibition of p53 by pifithrin-alpha significantly reduced the levels of PUMA, Bax, and PTEN but restored AKT phosphorylation in SiHa cells exposed to sesamin.	pifithrin	21-36	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
32922194-10	2020	Inhibition of p53 by pifithrin-alpha significantly reduced the levels of PUMA, Bax, and PTEN but restored AKT phosphorylation in SiHa cells exposed to sesamin.	pifithrin	21-36	phosphatase and tensin homolog	Homo sapiens	88-92
32922194-10	2020	Inhibition of p53 by pifithrin-alpha significantly reduced the levels of PUMA, Bax, and PTEN but restored AKT phosphorylation in SiHa cells exposed to sesamin.	pifithrin	21-36	AKT serine/threonine kinase 1	Homo sapiens	106-109
32757802-7	2021	The synergistic antitumor effect of API and CDDP was blocked by addition of the p53 inhibitor Pifithrin-alpha, and siRNA targeting the p53 gene in A549R cells.	pifithrin	94-109	tumor protein p53	Homo sapiens	80-83
32776944-9	2020	Depletion of p53 or applying the p53 inhibitor Pifithrin-alpha significantly rescued the hair cell loss in the Thoc1 knockdown zebrafish.	pifithrin	47-62	tumor protein p53	Danio rerio	33-36
32776944-9	2020	Depletion of p53 or applying the p53 inhibitor Pifithrin-alpha significantly rescued the hair cell loss in the Thoc1 knockdown zebrafish.	pifithrin	47-62	THO complex 1	Danio rerio	111-116
32120128-3	2020	To strengthen the bioactivity of the scaffolds, pifithrin-alpha (PFTalpha), a p53 inhibitor that can reduce the repressive function of p53 in osteogenesis, was preloaded in the PLGA electrospinning solution.	pifithrin	48-63	tumor protein p53	Homo sapiens	78-81
32120128-3	2020	To strengthen the bioactivity of the scaffolds, pifithrin-alpha (PFTalpha), a p53 inhibitor that can reduce the repressive function of p53 in osteogenesis, was preloaded in the PLGA electrospinning solution.	pifithrin	48-63	tumor protein p53	Homo sapiens	135-138
32120128-3	2020	To strengthen the bioactivity of the scaffolds, pifithrin-alpha (PFTalpha), a p53 inhibitor that can reduce the repressive function of p53 in osteogenesis, was preloaded in the PLGA electrospinning solution.	pifithrin	65-73	tumor protein p53	Homo sapiens	135-138
32216931-9	2020	Treatment with Pifithrin-alpha suppressed the increase in abundance of P53 and P21 proteins induced by the relatively greater concentration of Se (16.0 mumol/L), however, did not result in a change in abundances of P27 and BAX proteins.	pifithrin	15-30	cellular tumor antigen p53	Ovis aries	71-74
32534357-10	2020	The apoptosis induced by EPI in MKN-45 cells would be effectively inhibited with the treatment of p53 siRNA and p53 inhibitor PFT-alpha.	pifithrin	126-135	tumor protein p53	Homo sapiens	112-115
32299471-8	2020	In this study, nilotinib and pifithrin-alpha was used as a c-Abl and p53 inhibitor, respectively.	pifithrin	29-44	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	59-64
32299471-8	2020	In this study, nilotinib and pifithrin-alpha was used as a c-Abl and p53 inhibitor, respectively.	pifithrin	29-44	transformation related protein 53, pseudogene	Mus musculus	69-72
31838664-4	2020	Our observations suggest that P53 suppression by LPS, pifithrin, or small interfering RNA increased the expression of the redox marker malondialdehyde.	pifithrin	54-63	tumor protein p53	Homo sapiens	30-33
32048816-8	2020	Consistently, inhibition of P53 with pifithrin-alpha hydrobromide ameliorated PA-induced metabolic reprogramming and IR.	pifithrin	37-65	transformation related protein 53, pseudogene	Mus musculus	28-31
32256964-8	2020	As expected, an upregulation of p53 was observed after DpdtC insulting; however, the addition of a p53 inhibitor, PFT-alpha, could significantly attenuate the action of DpdtC on ferritinophagy induction and EMT inhibition.	pifithrin	114-123	tumor protein p53	Homo sapiens	32-35
32256964-8	2020	As expected, an upregulation of p53 was observed after DpdtC insulting; however, the addition of a p53 inhibitor, PFT-alpha, could significantly attenuate the action of DpdtC on ferritinophagy induction and EMT inhibition.	pifithrin	114-123	tumor protein p53	Homo sapiens	99-102
31778663-0	2020	The p53 inactivators pifithrin-mu and pifithrin-alpha mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy.	pifithrin	21-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
31701691-9	2020	Moreover pifithrin-alpha inhibited the FGF21-induced preventive effects on the renal EMT and subsequent renal fibrosis in DN mice.	pifithrin	9-24	fibroblast growth factor 21	Mus musculus	39-44
31778663-0	2020	The p53 inactivators pifithrin-mu and pifithrin-alpha mitigate TBI-induced neuronal damage through regulation of oxidative stress, neuroinflammation, autophagy and mitophagy.	pifithrin	38-47	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
31778663-2	2020	We investigated whether inhibition of p53 using pifithrin (PFT)-alpha or PFT-mu provides neuroprotective effects via p53 transcriptional dependent or -independent mechanisms, respectively.	pifithrin	48-69	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	38-41
31778663-7	2020	Fluoro-Jade C staining was used to label degenerating neurons within the TBI-induced cortical contusion region that, together with Annexin V positive neurons, were reduced by PFT-mu.	pifithrin	175-178	annexin A5	Rattus norvegicus	131-140
31778663-10	2020	PFT-alpha, but not PFT-mu, significantly lowered p53 mRNA expression.	pifithrin	0-3	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	49-52
31778663-11	2020	Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62).	pifithrin	5-8	interleukin 1 beta	Rattus norvegicus	74-82
31778663-11	2020	Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62).	pifithrin	5-8	interleukin 6	Rattus norvegicus	87-91
31778663-11	2020	Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62).	pifithrin	5-8	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	168-171
31778663-11	2020	Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62).	pifithrin	19-22	interleukin 1 beta	Rattus norvegicus	74-82
31778663-11	2020	Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62).	pifithrin	19-22	interleukin 6	Rattus norvegicus	87-91
31778663-11	2020	Both PFT-alpha and PFT-mu lowered TBI-induced pro-inflammatory cytokines (IL-1beta and IL-6) mRNA levels as well as TBI-induced autophagic marker localization (LC3 and p62).	pifithrin	19-22	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	168-171
31778663-12	2020	Finally, treatment with PFT-mu mitigated TBI-induced declines in mRNA levels of PINK-1 and SOD 2.	pifithrin	24-27	PTEN induced kinase 1	Rattus norvegicus	80-86
31778663-12	2020	Finally, treatment with PFT-mu mitigated TBI-induced declines in mRNA levels of PINK-1 and SOD 2.	pifithrin	24-27	superoxide dismutase 2	Rattus norvegicus	91-96
31707831-13	2020	Torin1 treatment increased protein expression of p53, and these effects were inhibited by pifithrin-alpha.	pifithrin	90-105	tumor protein p53	Homo sapiens	49-52
31841081-8	2020	When the p53 pathway of irradiated cells was inhibited by PFT-alpha, PFTmicro or p53 siRNA, the bystander damage to TK6 cells were clearly alleviated.	pifithrin	58-67	tumor protein p53	Homo sapiens	9-12
31974452-0	2020	Pifithrin-alpha alters p53 post-translational modifications pattern and differentially inhibits p53 target genes.	pifithrin	0-15	tumor protein p53	Homo sapiens	23-26
31974452-0	2020	Pifithrin-alpha alters p53 post-translational modifications pattern and differentially inhibits p53 target genes.	pifithrin	0-15	tumor protein p53	Homo sapiens	96-99
31974452-1	2020	Pifithrin-alpha (PFT-alpha) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity.	pifithrin	0-15	tumor protein p53	Homo sapiens	102-105
31974452-1	2020	Pifithrin-alpha (PFT-alpha) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity.	pifithrin	17-26	tumor protein p53	Homo sapiens	102-105
31974452-3	2020	PFT-alpha has also been described to display potent p53-independent activity in cells.	pifithrin	0-9	tumor protein p53	Homo sapiens	52-55
31974452-7	2020	PFT-alpha displayed a very limited effect on p53-dependent transcription upon its activation by Nutlin-3.	pifithrin	0-9	tumor protein p53	Homo sapiens	45-48
31974452-8	2020	Moreover, PFT-alpha inhibitory effect on transcription was highly dependent on the nature of the p53 target gene.	pifithrin	10-19	tumor protein p53	Homo sapiens	97-100
31974452-9	2020	PFT-alpha attenuated post-translational modifications of p53 without affecting total p53 protein level.	pifithrin	0-9	tumor protein p53	Homo sapiens	57-60
31974452-10	2020	Finally, we found that PFT-alpha can decrease the level of intracellular reactive oxygen species through activation of an aryl hydrocarbon receptor (AHR)-Nrf2 axis in a p53-independent manner.	pifithrin	23-32	aryl hydrocarbon receptor	Homo sapiens	122-147
31974452-10	2020	Finally, we found that PFT-alpha can decrease the level of intracellular reactive oxygen species through activation of an aryl hydrocarbon receptor (AHR)-Nrf2 axis in a p53-independent manner.	pifithrin	23-32	aryl hydrocarbon receptor	Homo sapiens	149-152
31974452-10	2020	Finally, we found that PFT-alpha can decrease the level of intracellular reactive oxygen species through activation of an aryl hydrocarbon receptor (AHR)-Nrf2 axis in a p53-independent manner.	pifithrin	23-32	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
31974452-10	2020	Finally, we found that PFT-alpha can decrease the level of intracellular reactive oxygen species through activation of an aryl hydrocarbon receptor (AHR)-Nrf2 axis in a p53-independent manner.	pifithrin	23-32	tumor protein p53	Homo sapiens	169-172
31974452-11	2020	In conclusion, PFT-alpha inhibits only some aspects of p53 function, therefore it should be used with extreme caution to study p53-dependent processes.	pifithrin	15-24	tumor protein p53	Homo sapiens	55-58
31974452-11	2020	In conclusion, PFT-alpha inhibits only some aspects of p53 function, therefore it should be used with extreme caution to study p53-dependent processes.	pifithrin	15-24	tumor protein p53	Homo sapiens	127-130
32749126-6	2020	The effect of EGb761 on the p53 signaling pathway was further confirmed by adding pifithrin (PFT)-alpha, an inhibitor of p53.	pifithrin	82-91	tumor protein p53	Homo sapiens	28-31
31853292-10	2020	The relationship between p53 and SDHA/HPRT1 expression was confirmed using western blot analysis following the application of pifithrin-alpha, a p53 inhibitor.	pifithrin	126-141	tumor protein p53	Equus caballus	25-28
31853292-10	2020	The relationship between p53 and SDHA/HPRT1 expression was confirmed using western blot analysis following the application of pifithrin-alpha, a p53 inhibitor.	pifithrin	126-141	succinate dehydrogenase complex flavoprotein subunit A	Equus caballus	33-37
31853292-10	2020	The relationship between p53 and SDHA/HPRT1 expression was confirmed using western blot analysis following the application of pifithrin-alpha, a p53 inhibitor.	pifithrin	126-141	hypoxanthine phosphoribosyltransferase 1	Equus caballus	38-43
31853292-10	2020	The relationship between p53 and SDHA/HPRT1 expression was confirmed using western blot analysis following the application of pifithrin-alpha, a p53 inhibitor.	pifithrin	126-141	tumor protein p53	Equus caballus	145-148
32771207-6	2020	Inhibition of p53 by treated with pifithrin-alpha (PFTalpha) causing augments of osteoclastogenesis and bone resorption, also reversed OPG-mediated inhibition of osteoclastogenesis by reducing the expression of TSC2.	pifithrin	34-49	tumor protein p53	Homo sapiens	14-17
32771207-6	2020	Inhibition of p53 by treated with pifithrin-alpha (PFTalpha) causing augments of osteoclastogenesis and bone resorption, also reversed OPG-mediated inhibition of osteoclastogenesis by reducing the expression of TSC2.	pifithrin	34-49	TNF receptor superfamily member 11b	Homo sapiens	135-138
32771207-6	2020	Inhibition of p53 by treated with pifithrin-alpha (PFTalpha) causing augments of osteoclastogenesis and bone resorption, also reversed OPG-mediated inhibition of osteoclastogenesis by reducing the expression of TSC2.	pifithrin	34-49	TSC complex subunit 2	Homo sapiens	211-215
32771207-6	2020	Inhibition of p53 by treated with pifithrin-alpha (PFTalpha) causing augments of osteoclastogenesis and bone resorption, also reversed OPG-mediated inhibition of osteoclastogenesis by reducing the expression of TSC2.	pifithrin	51-59	tumor protein p53	Homo sapiens	14-17
32771207-6	2020	Inhibition of p53 by treated with pifithrin-alpha (PFTalpha) causing augments of osteoclastogenesis and bone resorption, also reversed OPG-mediated inhibition of osteoclastogenesis by reducing the expression of TSC2.	pifithrin	51-59	TNF receptor superfamily member 11b	Homo sapiens	135-138
32771207-6	2020	Inhibition of p53 by treated with pifithrin-alpha (PFTalpha) causing augments of osteoclastogenesis and bone resorption, also reversed OPG-mediated inhibition of osteoclastogenesis by reducing the expression of TSC2.	pifithrin	51-59	TSC complex subunit 2	Homo sapiens	211-215
32749126-6	2020	The effect of EGb761 on the p53 signaling pathway was further confirmed by adding pifithrin (PFT)-alpha, an inhibitor of p53.	pifithrin	82-91	tumor protein p53	Homo sapiens	121-124
32749126-6	2020	The effect of EGb761 on the p53 signaling pathway was further confirmed by adding pifithrin (PFT)-alpha, an inhibitor of p53.	pifithrin	93-96	tumor protein p53	Homo sapiens	28-31
32749126-6	2020	The effect of EGb761 on the p53 signaling pathway was further confirmed by adding pifithrin (PFT)-alpha, an inhibitor of p53.	pifithrin	93-96	tumor protein p53	Homo sapiens	121-124
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	transformation related protein 53, pseudogene	Mus musculus	17-20
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	conserved helix-loop-helix ubiquitous kinase	Mus musculus	80-87
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	89-101
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	119-122
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	150-155
31618665-12	2020	Mechanistically, p53 antagonist PFTalpha abolished TP-induced the inhibition of IKKbeta, IkappaBalpha phosphorylation, p65 nuclear translocation, and GLUT1, GLUT4 expression.	pifithrin	32-40	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	157-162
31472452-8	2019	UGT1A8 was inhibited by 97.6%, 94.8%, 86.3%, 83.4% and 77.1% by PFDA, PFTA, perfluorooctadecanoic acid (PFOcDA), PFDoA and PFOS, respectively.	pifithrin	70-74	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	0-6
31237956-11	2019	The inhibition of p53 with pifithrin alpha or siRNA counteracted the effects of NCDAP1.	pifithrin	27-42	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	18-21
31906131-6	2019	To further confirm these observations, cultured podocytes were treated with the P53 inhibitor pifithrin-alpha, which showed significant protection from ADR-induced actin cytoskeleton damage.	pifithrin	94-109	transformation related protein 53, pseudogene	Mus musculus	80-83
31621504-2	2019	The strength of this study is to incorporate gelatin hydrogel microspheres (GM) containing pifithrin-alpha (PFT) of a p53 inhibitor (GM-PFT) with the CAF aggregates.	pifithrin	91-106	tumor protein p53	Sus scrofa	118-121
31472452-7	2019	The activity of UGT1A1 was inhibited by 98.8%, 98%, 79.9%, 77.1%, and 76.9% at 100 mumoL/L of perfluorodecanoic acid (PFDA), perfluorooctanesulfonic acid potassium salt (PFOS), perfluorotetradecanoic acid (PFTA), perfluorooctanoic acid (PFOA) and perfluorododecanoic acid (PFDoA), respectively.	pifithrin	206-210	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	16-22
31472452-11	2019	PFDA and PFOS exhibited competitive inhibition towards UGT1A1, and PFDA and PFTA showed competitive inhibition towards UGT1A8.	pifithrin	76-80	UDP glucuronosyltransferase family 1 member A8	Homo sapiens	119-125
31601054-6	2019	Furthermore, the effects of cell cycle arrest and apoptosis in A549 cells which were induced by actinomycin V could be reversed by the pifithrin-alpha, a specific inhibitor of p53 transcriptional activity.	pifithrin	135-150	tumor protein p53	Homo sapiens	176-179
31155771-7	2019	Additionally, under the pretreatment of pifithrin-a (PFT-a, a p53 inhibitor), the magnolol-induced apoptosis was significantly reversed.	pifithrin	40-51	tumor protein p53	Homo sapiens	62-65
27025925-6	2019	Caspase-3 inhibitor (Ac-DEVD-CHO at concentrations between 10 to 20 mumol/L), p53 inhibitor (pifithrin-alpha at 5 mumol/L) and cyclosporin A can attenuate the apoptotic effect of psoralidin.	pifithrin	93-108	tumor protein p53	Homo sapiens	78-81
31148231-3	2019	We find that p53 was upregulated in cisplatin-induced AKI, yet, pifithrin-alpha inhibites the p53 expression to attenuated renal injury and cell apoptosis both in vivo cisplatin-induced AKI mice and in vitro HK-2 human renal tubular epithelial cells.	pifithrin	64-73	transformation related protein 53, pseudogene	Mus musculus	94-97
31155771-7	2019	Additionally, under the pretreatment of pifithrin-a (PFT-a, a p53 inhibitor), the magnolol-induced apoptosis was significantly reversed.	pifithrin	53-58	tumor protein p53	Homo sapiens	62-65
31377450-4	2019	Pifithrin-alpha, a selective p53 inhibitor, was administered to assess its effects on diabetic pain hypersensitivity, parkin expression and mitochondrial function.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	29-32
31377450-10	2019	Inhibition of p53 by pifithrin-alpha prevented STZ-induced pain hypersensitivity and parkin downregulation.	pifithrin	21-36	transformation related protein 53, pseudogene	Mus musculus	14-17
31069753-3	2019	A recent study indicated that treatment with the p53 inhibitor, pifithrin-alpha (PFT-alpha), antagonized Meth-mediated behavioral deficits in mice.	pifithrin	64-79	transformation related protein 53, pseudogene	Mus musculus	49-52
30879173-6	2019	The cytotoxicity of RH1 was inhibited in A549 cells treated with the p53-inhibitor pifithrin-alpha or transfected p53 siRNA and in human colon cancer HCT116 isogenic (p53-/-) cells.	pifithrin	83-98	tumor protein p53	Homo sapiens	69-72
31420372-9	2019	Furthermore, the concentrations of Bax and p53-upregulated modulator of apoptosis were significantly decreased with that of Bcl-2 being significantly increased by administration of SN50, PFT-alpha and ginkgetin.	pifithrin	187-196	BCL2 associated X, apoptosis regulator	Rattus norvegicus	35-38
31420372-9	2019	Furthermore, the concentrations of Bax and p53-upregulated modulator of apoptosis were significantly decreased with that of Bcl-2 being significantly increased by administration of SN50, PFT-alpha and ginkgetin.	pifithrin	187-196	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	43-46
31420372-9	2019	Furthermore, the concentrations of Bax and p53-upregulated modulator of apoptosis were significantly decreased with that of Bcl-2 being significantly increased by administration of SN50, PFT-alpha and ginkgetin.	pifithrin	187-196	BCL2, apoptosis regulator	Rattus norvegicus	124-129
30959066-9	2019	Deletion of the Nrf2 gene completely abrogated the efficacies of SRT2104 and PFT-alpha in elevating antioxidants and ameliorating DN, despite their abilities to activate SIRT1 and inhibit P53 in the Nrf2 KO mice.	pifithrin	77-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
30959066-9	2019	Deletion of the Nrf2 gene completely abrogated the efficacies of SRT2104 and PFT-alpha in elevating antioxidants and ameliorating DN, despite their abilities to activate SIRT1 and inhibit P53 in the Nrf2 KO mice.	pifithrin	77-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	199-203
30628118-10	2019	The cytotoxic effects of solasonine correlated in part with its apoptotic properties and differed in the two HCC cell lines, being reversed by pifithrin-alpha, an inhibitor of p53 functions, in HepG2 cells but not in Hep3b cells.	pifithrin	143-158	tumor protein p53	Homo sapiens	176-179
31069753-3	2019	A recent study indicated that treatment with the p53 inhibitor, pifithrin-alpha (PFT-alpha), antagonized Meth-mediated behavioral deficits in mice.	pifithrin	81-90	transformation related protein 53, pseudogene	Mus musculus	49-52
31069753-8	2019	PFT-alpha also reduced Meth-activated translocation of p53 to the nucleus, an initial step before transcription.	pifithrin	0-9	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	55-58
31069753-13	2019	Additionally, PFT-alpha significantly attenuated Meth-induced CHOP expression.	pifithrin	14-23	DNA damage inducible transcript 3	Homo sapiens	62-66
31138778-8	2019	The p53 inhibitor pifithrin-alpha attenuated the influences of ZCCHC10 overexpression on p53 pathway, cell cycle, apoptosis, and epithelial-mesenchymal transition, whereas the p53 activator Nutlin3 could reverse the effects of ZCCHC10 knockdown.	pifithrin	18-33	tumor protein p53	Homo sapiens	4-7
31334116-5	2019	In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-alpha) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis.	pifithrin	55-64	tumor protein p53	Homo sapiens	33-36
31334116-5	2019	In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-alpha) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis.	pifithrin	55-64	tumor protein p53	Homo sapiens	180-183
31334116-5	2019	In addition, co-treatment with a p53 inhibitor (cyclic pifithrin-alpha) and the ruthenium complexes significantly reduced the apoptosis rate in HCT116 cells, and increased phospho-p53 (S15) and phospho-histone H2AX (S139) expressions, indicating induction of DNA damage and p53-dependent apoptosis.	pifithrin	55-64	tumor protein p53	Homo sapiens	180-183
31138778-8	2019	The p53 inhibitor pifithrin-alpha attenuated the influences of ZCCHC10 overexpression on p53 pathway, cell cycle, apoptosis, and epithelial-mesenchymal transition, whereas the p53 activator Nutlin3 could reverse the effects of ZCCHC10 knockdown.	pifithrin	18-33	zinc finger CCHC-type containing 10	Homo sapiens	63-70
31138778-8	2019	The p53 inhibitor pifithrin-alpha attenuated the influences of ZCCHC10 overexpression on p53 pathway, cell cycle, apoptosis, and epithelial-mesenchymal transition, whereas the p53 activator Nutlin3 could reverse the effects of ZCCHC10 knockdown.	pifithrin	18-33	tumor protein p53	Homo sapiens	89-92
31138778-8	2019	The p53 inhibitor pifithrin-alpha attenuated the influences of ZCCHC10 overexpression on p53 pathway, cell cycle, apoptosis, and epithelial-mesenchymal transition, whereas the p53 activator Nutlin3 could reverse the effects of ZCCHC10 knockdown.	pifithrin	18-33	tumor protein p53	Homo sapiens	89-92
31138778-8	2019	The p53 inhibitor pifithrin-alpha attenuated the influences of ZCCHC10 overexpression on p53 pathway, cell cycle, apoptosis, and epithelial-mesenchymal transition, whereas the p53 activator Nutlin3 could reverse the effects of ZCCHC10 knockdown.	pifithrin	18-33	zinc finger CCHC-type containing 10	Homo sapiens	227-234
30103008-11	2018	Both p53 inhibitor pifithrin-alpha and p53 siRNA significantly rescued costunolide suppression of GLS1 promoter activity and expression in HCT116 cells.	pifithrin	19-34	tumor protein p53	Homo sapiens	5-8
30660711-7	2019	In some assay p53 activity of NSCLC ( A549 and H460) cells were blocked with pifithrin-a, prior to treatment with ZQT.	pifithrin	77-88	tumor protein p53	Homo sapiens	14-17
31019655-13	2019	Meanwhile, ROS scavenger NAC, JNK inhibitor SP600125, and p53 inhibitor PFTalpha were used to verify that autophagy-mediated upregulation of DR5 was regulated by the SNX-2112-stimulated activation of the ROS-JNK-p53 signaling pathway.	pifithrin	72-80	TNF receptor superfamily member 10b	Homo sapiens	141-144
30472223-8	2019	Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis.	pifithrin	10-18	tumor protein p53	Homo sapiens	75-78
30472223-8	2019	Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis.	pifithrin	10-18	tumor protein p53	Homo sapiens	75-78
30551455-8	2019	Suppressing p53 expressions with its inhibitor, PFTalpha, blocked apoptotic response in JMJD5-silenced cells.	pifithrin	48-56	tumor protein p53	Homo sapiens	12-15
30551455-8	2019	Suppressing p53 expressions with its inhibitor, PFTalpha, blocked apoptotic response in JMJD5-silenced cells.	pifithrin	48-56	lysine demethylase 8	Homo sapiens	88-93
30551455-9	2019	JMJD5 inhibition-induced decrease of nuclear factor-kappaB (NF-kappaB) was rescued by pifithrin-alpha (PFTalpha) pre-treatment.	pifithrin	86-101	lysine demethylase 8	Homo sapiens	0-5
30551455-9	2019	JMJD5 inhibition-induced decrease of nuclear factor-kappaB (NF-kappaB) was rescued by pifithrin-alpha (PFTalpha) pre-treatment.	pifithrin	86-101	nuclear factor kappa B subunit 1	Homo sapiens	37-58
30551455-9	2019	JMJD5 inhibition-induced decrease of nuclear factor-kappaB (NF-kappaB) was rescued by pifithrin-alpha (PFTalpha) pre-treatment.	pifithrin	86-101	nuclear factor kappa B subunit 1	Homo sapiens	60-69
30551455-9	2019	JMJD5 inhibition-induced decrease of nuclear factor-kappaB (NF-kappaB) was rescued by pifithrin-alpha (PFTalpha) pre-treatment.	pifithrin	103-111	lysine demethylase 8	Homo sapiens	0-5
30551455-9	2019	JMJD5 inhibition-induced decrease of nuclear factor-kappaB (NF-kappaB) was rescued by pifithrin-alpha (PFTalpha) pre-treatment.	pifithrin	103-111	nuclear factor kappa B subunit 1	Homo sapiens	37-58
30551455-9	2019	JMJD5 inhibition-induced decrease of nuclear factor-kappaB (NF-kappaB) was rescued by pifithrin-alpha (PFTalpha) pre-treatment.	pifithrin	103-111	nuclear factor kappa B subunit 1	Homo sapiens	60-69
30145226-6	2019	Treatment with pifithrin-alpha-HBr (PFTalpha), a specific blocker of p53-responsive gene transactivation, reduced the P4-increased p27 promoter activity and p27 protein expression.	pifithrin	36-44	tumor protein p53	Homo sapiens	69-72
30145226-6	2019	Treatment with pifithrin-alpha-HBr (PFTalpha), a specific blocker of p53-responsive gene transactivation, reduced the P4-increased p27 promoter activity and p27 protein expression.	pifithrin	36-44	interferon alpha inducible protein 27	Homo sapiens	131-134
30145226-6	2019	Treatment with pifithrin-alpha-HBr (PFTalpha), a specific blocker of p53-responsive gene transactivation, reduced the P4-increased p27 promoter activity and p27 protein expression.	pifithrin	36-44	interferon alpha inducible protein 27	Homo sapiens	157-160
30543781-7	2019	TCCP treatment caused endogenous ROS generation, increase in intracellular calcium and phosphorylation of p53 in a concentration-dependent manner, which was reverted upon pre-treatment with pifithrin-mu.	pifithrin	190-199	tumor protein p53	Homo sapiens	106-109
30472223-0	2019	Pifithrin-alpha enhancing anticancer effect of topotecan on p53-expressing cancer cells.	pifithrin	0-9	tumor protein p53	Homo sapiens	60-63
30472223-3	2019	In this study, pifithrin-alpha (PFTalpha), a p53 inhibitor, was used 2 h before treated with TPT on three kinds of cancer cell lines including MCF7, BGC823 and HepG2 cells.	pifithrin	15-30	tumor protein p53	Homo sapiens	45-48
30472223-3	2019	In this study, pifithrin-alpha (PFTalpha), a p53 inhibitor, was used 2 h before treated with TPT on three kinds of cancer cell lines including MCF7, BGC823 and HepG2 cells.	pifithrin	32-40	tumor protein p53	Homo sapiens	45-48
30472223-5	2019	It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells.	pifithrin	25-33	tumor protein p53	Homo sapiens	50-53
30472223-5	2019	It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells.	pifithrin	25-33	tumor protein p53	Homo sapiens	67-70
30472223-5	2019	It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells.	pifithrin	25-33	tumor protein p53	Homo sapiens	67-70
30472223-5	2019	It was demonstrated that PFTalpha decreases the p-p53 levels and p-p53 activity, not affects p53 expression in p53 positive tumor cells.	pifithrin	25-33	tumor protein p53	Homo sapiens	67-70
30472223-8	2019	Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis.	pifithrin	10-18	tumor protein p53	Homo sapiens	42-45
30472223-8	2019	Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis.	pifithrin	10-18	MDM2 proto-oncogene	Homo sapiens	46-50
30472223-8	2019	Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis.	pifithrin	10-18	tumor protein p53	Homo sapiens	75-78
30472223-8	2019	Secondly, PFTalpha decreased formation of p53/mdm2 complex responsible for p53 degradation by inhibiting the protein expression of mdm2, so p53 degradation was decreased in cytoplasm and p53 accumulation was increased in nucleus, which induced more cells undergo apoptosis.	pifithrin	10-18	MDM2 proto-oncogene	Homo sapiens	131-135
30103008-11	2018	Both p53 inhibitor pifithrin-alpha and p53 siRNA significantly rescued costunolide suppression of GLS1 promoter activity and expression in HCT116 cells.	pifithrin	19-34	glutaminase	Homo sapiens	98-102
30126780-8	2018	The p53 inhibitor and activator pifithrin-alpha and quinacrine, respectively, were used to modulate p53 activity in vivo after ischemia.	pifithrin	32-47	transformation related protein 53, pseudogene	Mus musculus	100-103
30545932-8	2018	Correspondingly, embryos cultured with p53 transcriptional activity inhibitor pifithrin-alpha could overcome TPEN-induced apoptosis and failure of neural tube closure.	pifithrin	78-87	tumor protein p53	Homo sapiens	39-42
30126780-14	2018	Conversely, inhibition of p53 with pifithrin-alpha augmented limb perfusion (P < .05) and collateral artery formation (P < .05) and increased protein levels of hypoxia-inducible factor 1alpha and VEGF.	pifithrin	35-44	transformation related protein 53, pseudogene	Mus musculus	26-29
30126780-14	2018	Conversely, inhibition of p53 with pifithrin-alpha augmented limb perfusion (P < .05) and collateral artery formation (P < .05) and increased protein levels of hypoxia-inducible factor 1alpha and VEGF.	pifithrin	35-44	hypoxia inducible factor 1, alpha subunit	Mus musculus	166-197
30126780-14	2018	Conversely, inhibition of p53 with pifithrin-alpha augmented limb perfusion (P < .05) and collateral artery formation (P < .05) and increased protein levels of hypoxia-inducible factor 1alpha and VEGF.	pifithrin	35-44	vascular endothelial growth factor A	Mus musculus	202-206
30009776-9	2018	Consistently, p53 antagonist PFTalpha counteracted TP-induced p53 overexpression and regulation of Bcl2 family transcription, which improved mitochondrial membrane integrity and prevented apoptosis.	pifithrin	29-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	14-17
30066840-3	2018	The present study demonstrated that suppression of HSP70 through the specific inhibitor pifithrin-micro or by HSP70 knockdown enhanced cisplatin-induced apoptosis in HGC-27 gastric cancer cells.	pifithrin	88-97	heat shock protein family A (Hsp70) member 4	Homo sapiens	51-56
30272369-5	2018	Subsequently, the expression trends of Bcl-2 and p53 were reversed after co-treatment with pifithrin-alpha (PFT-alpha, a p53 inhibitor).	pifithrin	91-106	BCL2 apoptosis regulator	Homo sapiens	39-44
30272369-5	2018	Subsequently, the expression trends of Bcl-2 and p53 were reversed after co-treatment with pifithrin-alpha (PFT-alpha, a p53 inhibitor).	pifithrin	91-106	tumor protein p53	Homo sapiens	49-52
30272369-5	2018	Subsequently, the expression trends of Bcl-2 and p53 were reversed after co-treatment with pifithrin-alpha (PFT-alpha, a p53 inhibitor).	pifithrin	91-106	tumor protein p53	Homo sapiens	121-124
30080692-8	2018	We further found that pifithrin-alpha, a p53 inhibitor, attenuated the anticancer effects of VX-680 and downregulated the expression of apotosis-related proteins (Bax and caspase-9).	pifithrin	22-37	tumor protein p53	Homo sapiens	41-44
30080692-8	2018	We further found that pifithrin-alpha, a p53 inhibitor, attenuated the anticancer effects of VX-680 and downregulated the expression of apotosis-related proteins (Bax and caspase-9).	pifithrin	22-37	BCL2 associated X, apoptosis regulator	Homo sapiens	163-166
30080692-8	2018	We further found that pifithrin-alpha, a p53 inhibitor, attenuated the anticancer effects of VX-680 and downregulated the expression of apotosis-related proteins (Bax and caspase-9).	pifithrin	22-37	caspase 9	Homo sapiens	171-180
30009776-9	2018	Consistently, p53 antagonist PFTalpha counteracted TP-induced p53 overexpression and regulation of Bcl2 family transcription, which improved mitochondrial membrane integrity and prevented apoptosis.	pifithrin	29-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	62-65
30009776-9	2018	Consistently, p53 antagonist PFTalpha counteracted TP-induced p53 overexpression and regulation of Bcl2 family transcription, which improved mitochondrial membrane integrity and prevented apoptosis.	pifithrin	29-37	BCL2, apoptosis regulator	Rattus norvegicus	99-103
29802837-6	2018	The dissociation-induced increase of phosphorylated p53 Ser15 (p-p53) is suppressed by Pifithrin alpha which also rescues the elevated levels of pro-apoptotic proteins in mitochondrial pathway.	pifithrin	87-102	tumor protein p53	Homo sapiens	52-55
29944886-12	2018	Moreover, suppressing p53 expression with its inhibitor of PFTalpha abrogated the activity of LHPP to impede cell proliferation and metastasis, and to trigger apoptosis.	pifithrin	59-67	tumor protein p53	Homo sapiens	22-25
29944886-12	2018	Moreover, suppressing p53 expression with its inhibitor of PFTalpha abrogated the activity of LHPP to impede cell proliferation and metastasis, and to trigger apoptosis.	pifithrin	59-67	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	Homo sapiens	94-98
29802837-6	2018	The dissociation-induced increase of phosphorylated p53 Ser15 (p-p53) is suppressed by Pifithrin alpha which also rescues the elevated levels of pro-apoptotic proteins in mitochondrial pathway.	pifithrin	87-102	tumor protein p53	Homo sapiens	65-68
30112029-6	2018	ECH (10 mg/l) or pifithrin-alpha (PFT-alpha) (a p53 inhibitor, 20 microM) suppressed dexamethasone-induced MC3T3-E1 apoptosis as illustrated by Annexin V/propidium iodide (PI) double-labeling flow cytometry analysis.	pifithrin	17-32	transformation related protein 53, pseudogene	Mus musculus	48-51
30112029-6	2018	ECH (10 mg/l) or pifithrin-alpha (PFT-alpha) (a p53 inhibitor, 20 microM) suppressed dexamethasone-induced MC3T3-E1 apoptosis as illustrated by Annexin V/propidium iodide (PI) double-labeling flow cytometry analysis.	pifithrin	17-32	annexin A5	Mus musculus	144-153
29704532-9	2018	On the contrary, P53 inhibition by pifithrin-alpha activated renal NRF2 signaling and the expression of Mdm2, and attenuated DKD in the WT diabetic mice, but not in the Nrf2 KO diabetic mice.	pifithrin	35-44	transformation related protein 53, pseudogene	Mus musculus	17-20
29401620-6	2018	The inductive response was suppressed by pifithrin (a pharmacological inhibitor of P53), suggesting a role of P53 in FGF21 induction.	pifithrin	41-50	transformation related protein 53, pseudogene	Mus musculus	83-86
29704532-9	2018	On the contrary, P53 inhibition by pifithrin-alpha activated renal NRF2 signaling and the expression of Mdm2, and attenuated DKD in the WT diabetic mice, but not in the Nrf2 KO diabetic mice.	pifithrin	35-44	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
29704532-9	2018	On the contrary, P53 inhibition by pifithrin-alpha activated renal NRF2 signaling and the expression of Mdm2, and attenuated DKD in the WT diabetic mice, but not in the Nrf2 KO diabetic mice.	pifithrin	35-44	transformed mouse 3T3 cell double minute 2	Mus musculus	104-108
29890190-7	2018	Pharmacologically inhibiting p53 with Pifithrin-alpha or genetically employing p53 heterozygous mice to enforce the inactivation of p53 in Fmr1 knockout cultures restored the synchronization of neural network activity after chronic activity stimulation and partially corrects the homeostatic reduction of neural network spike amplitude.	pifithrin	38-47	transformation related protein 53, pseudogene	Mus musculus	29-32
29890190-7	2018	Pharmacologically inhibiting p53 with Pifithrin-alpha or genetically employing p53 heterozygous mice to enforce the inactivation of p53 in Fmr1 knockout cultures restored the synchronization of neural network activity after chronic activity stimulation and partially corrects the homeostatic reduction of neural network spike amplitude.	pifithrin	38-47	fragile X messenger ribonucleoprotein 1	Mus musculus	139-143
29401620-6	2018	The inductive response was suppressed by pifithrin (a pharmacological inhibitor of P53), suggesting a role of P53 in FGF21 induction.	pifithrin	41-50	transformation related protein 53, pseudogene	Mus musculus	110-113
29401620-6	2018	The inductive response was suppressed by pifithrin (a pharmacological inhibitor of P53), suggesting a role of P53 in FGF21 induction.	pifithrin	41-50	fibroblast growth factor 21	Mus musculus	117-122
31938352-11	2018	The protein levels of bax and cl-caspase-3 were significantly decreased and the expression of bcl-2 was increased after pretreated with p53 specific inhibitor pifithrin-alpha.	pifithrin	159-174	BCL2 associated X, apoptosis regulator	Homo sapiens	22-25
29525471-6	2018	Prolonged expression of p53 was responsible for melanocyte senescence and hyperpigmentation, and treatment with the p53-inhibitor pifithrin-alpha at 2-weeks post-UVB irradiation, but not at 48 h, significantly reduced melanin content along with decreases in tyrosinase levels.	pifithrin	130-145	tumor protein p53	Homo sapiens	24-27
29525471-6	2018	Prolonged expression of p53 was responsible for melanocyte senescence and hyperpigmentation, and treatment with the p53-inhibitor pifithrin-alpha at 2-weeks post-UVB irradiation, but not at 48 h, significantly reduced melanin content along with decreases in tyrosinase levels.	pifithrin	130-145	tumor protein p53	Homo sapiens	116-119
29525471-6	2018	Prolonged expression of p53 was responsible for melanocyte senescence and hyperpigmentation, and treatment with the p53-inhibitor pifithrin-alpha at 2-weeks post-UVB irradiation, but not at 48 h, significantly reduced melanin content along with decreases in tyrosinase levels.	pifithrin	130-145	tyrosinase	Homo sapiens	258-268
29899847-8	2018	In contrast, an inhibitor for HSP70 with a chaperon function, pifithrin-mu, did not produce the p53 down-regulation.	pifithrin	62-71	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-35
31938352-11	2018	The protein levels of bax and cl-caspase-3 were significantly decreased and the expression of bcl-2 was increased after pretreated with p53 specific inhibitor pifithrin-alpha.	pifithrin	159-174	BCL2 apoptosis regulator	Homo sapiens	94-99
31938352-11	2018	The protein levels of bax and cl-caspase-3 were significantly decreased and the expression of bcl-2 was increased after pretreated with p53 specific inhibitor pifithrin-alpha.	pifithrin	159-174	tumor protein p53	Homo sapiens	136-139
29402897-3	2018	We investigated how the p53 inactivator pifithrin (PFT)-alpha affected TBI-induced striatal neuronal damage at 24 h post-injury.	pifithrin	40-49	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	24-27
29344658-8	2018	Suppression of p53 activity using the specific p53 inhibitor pifithrin-alpha alleviated sevoflurane-induced neuroapoptosis.	pifithrin	61-70	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	15-18
29344658-8	2018	Suppression of p53 activity using the specific p53 inhibitor pifithrin-alpha alleviated sevoflurane-induced neuroapoptosis.	pifithrin	61-70	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
29467390-14	2018	Indeed, p53 accumulates at mitochondria upon etoposide treatment and inhibition of p53 mitochondrial localization using pifithrin-micro inhibits apoptosis of COV434 cells.	pifithrin	120-129	tumor protein p53	Homo sapiens	83-86
29207130-10	2018	Furthermore, treatment or co-treatment with LY294002 (phosphoinositide-3-kinase/Akt inhibitor) or Pifithrin-alpha (p53 inhibitor) with CME resulted in CME-induced G1 arrest which occurred through the p53-independent signaling pathway in hepatocellular carcinoma cells.	pifithrin	98-113	tumor protein p53	Homo sapiens	115-118
29512370-4	2018	For this purpose, mixed lymphocyte reaction (MLR) was performed using the IDO inhibitor 1-DL-methyl-tryptophan and the p53 inhibitor pifithrin-alpha.	pifithrin	133-148	tumor protein p53	Homo sapiens	119-122
29207130-10	2018	Furthermore, treatment or co-treatment with LY294002 (phosphoinositide-3-kinase/Akt inhibitor) or Pifithrin-alpha (p53 inhibitor) with CME resulted in CME-induced G1 arrest which occurred through the p53-independent signaling pathway in hepatocellular carcinoma cells.	pifithrin	98-113	tumor protein p53	Homo sapiens	200-203
28972153-3	2017	In three of these mutants, i.e. hDAT-V158F, hDAT-G327R, and hDAT-L368Q, the folding deficit was remedied with the pharmacochaperone noribogaine or the heat shock protein 70 (HSP70) inhibitor pifithrin-mu such that endoplasmic reticulum export of and radioligand binding and substrate uptake by these DAT mutants were restored.	pifithrin	191-200	solute carrier family 6 member 3	Homo sapiens	32-36
28562478-11	2018	CONCLUSION: Temporarily inhibition of apoptosis with pifithrin-mu after cardiac arrest decreases the number of injured neurons in the CA1 segment of hippocampus in a cardiac arrest rat model, without clinical correlate.	pifithrin	53-62	carbonic anhydrase 1	Rattus norvegicus	134-137
28990231-8	2017	Mechanistically, IFI16 could activate p53 at Ser15 to up-regulate the p21WAF1/CIP1 level to inhibit tumour growth and migration, which was restored by the p53 inhibitor Pifithrin-alpha (20 mumol/L).	pifithrin	169-184	interferon gamma inducible protein 16	Homo sapiens	17-22
28990231-8	2017	Mechanistically, IFI16 could activate p53 at Ser15 to up-regulate the p21WAF1/CIP1 level to inhibit tumour growth and migration, which was restored by the p53 inhibitor Pifithrin-alpha (20 mumol/L).	pifithrin	169-184	tumor protein p53	Homo sapiens	38-41
28990231-8	2017	Mechanistically, IFI16 could activate p53 at Ser15 to up-regulate the p21WAF1/CIP1 level to inhibit tumour growth and migration, which was restored by the p53 inhibitor Pifithrin-alpha (20 mumol/L).	pifithrin	169-184	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-82
28990231-8	2017	Mechanistically, IFI16 could activate p53 at Ser15 to up-regulate the p21WAF1/CIP1 level to inhibit tumour growth and migration, which was restored by the p53 inhibitor Pifithrin-alpha (20 mumol/L).	pifithrin	169-184	tumor protein p53	Homo sapiens	155-158
29039478-7	2017	In particular, inhibition of p53 by pifithrin-alpha, and upregulation of eIF2alpha phosphorylation by Sal003, reduced cisplatin-induced apoptosis.	pifithrin	36-45	tumor protein p53	Homo sapiens	29-32
28822073-6	2017	Inhibitions of MPP+-induced both cytochrome c release and caspase-9 activation by IRN were blocked by pre-treatment with DPI or pifithrin-alpha, but not by IRE-1alpha shRNA.	pifithrin	128-137	caspase 9	Rattus norvegicus	58-67
29278895-5	2018	RESULTS: In cultures of myogenic cells from MDC1A donors, p53 accumulated in a subset of nuclei and aberrant caspase activation was inhibited by the p53 inhibitor pifithrin-alpha.	pifithrin	163-178	tumor protein p53	Homo sapiens	58-61
29278895-5	2018	RESULTS: In cultures of myogenic cells from MDC1A donors, p53 accumulated in a subset of nuclei and aberrant caspase activation was inhibited by the p53 inhibitor pifithrin-alpha.	pifithrin	163-178	tumor protein p53	Homo sapiens	149-152
28972153-3	2017	In three of these mutants, i.e. hDAT-V158F, hDAT-G327R, and hDAT-L368Q, the folding deficit was remedied with the pharmacochaperone noribogaine or the heat shock protein 70 (HSP70) inhibitor pifithrin-mu such that endoplasmic reticulum export of and radioligand binding and substrate uptake by these DAT mutants were restored.	pifithrin	191-200	Dopamine transporter	Drosophila melanogaster	33-36
28972153-6	2017	Noribogaine or pifithrin-mu treatment supported hDAT delivery to the presynaptic terminals of dopaminergic neurons and restored sleep to normal length in DAT-deficient (fumin) Drosophila lines expressing hDAT-V158F or hDAT-G327R.	pifithrin	15-24	solute carrier family 6 member 3	Homo sapiens	48-52
28972153-6	2017	Noribogaine or pifithrin-mu treatment supported hDAT delivery to the presynaptic terminals of dopaminergic neurons and restored sleep to normal length in DAT-deficient (fumin) Drosophila lines expressing hDAT-V158F or hDAT-G327R.	pifithrin	15-24	Dopamine transporter	Drosophila melanogaster	49-52
28972153-6	2017	Noribogaine or pifithrin-mu treatment supported hDAT delivery to the presynaptic terminals of dopaminergic neurons and restored sleep to normal length in DAT-deficient (fumin) Drosophila lines expressing hDAT-V158F or hDAT-G327R.	pifithrin	15-24	solute carrier family 6 member 3	Homo sapiens	204-208
28972153-6	2017	Noribogaine or pifithrin-mu treatment supported hDAT delivery to the presynaptic terminals of dopaminergic neurons and restored sleep to normal length in DAT-deficient (fumin) Drosophila lines expressing hDAT-V158F or hDAT-G327R.	pifithrin	15-24	solute carrier family 6 member 3	Homo sapiens	204-208
29135937-11	2017	This was exemplified by rescuing disease-causing, folding-deficient variants of the human dopamine transporters with the HSP70 inhibitor pifithrin-mu and the pharmacochaperone noribogaine in Drosophila melanogaster.	pifithrin	137-146	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
29246013-5	2017	Therefore, PFTalpha, a p53 inhibitor, was introduced in this study to block the ethanol-triggered activation of p53 in hBMSCs and alcohol-induced ONFH in a rat model.	pifithrin	11-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	23-26
29212215-5	2017	We examined the molecular mechanism of this cell death pathway, and found that B2 protein induces the P53/Bax-mediated apoptotic pathway in A549 cells, and that a P53 specific inhibitor (pifithrin-alpha) switches this response to RIP3-mediated necroptosis.	pifithrin	187-196	tumor protein p53	Homo sapiens	102-105
29212215-5	2017	We examined the molecular mechanism of this cell death pathway, and found that B2 protein induces the P53/Bax-mediated apoptotic pathway in A549 cells, and that a P53 specific inhibitor (pifithrin-alpha) switches this response to RIP3-mediated necroptosis.	pifithrin	187-196	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
29212215-5	2017	We examined the molecular mechanism of this cell death pathway, and found that B2 protein induces the P53/Bax-mediated apoptotic pathway in A549 cells, and that a P53 specific inhibitor (pifithrin-alpha) switches this response to RIP3-mediated necroptosis.	pifithrin	187-196	tumor protein p53	Homo sapiens	163-166
29212215-5	2017	We examined the molecular mechanism of this cell death pathway, and found that B2 protein induces the P53/Bax-mediated apoptotic pathway in A549 cells, and that a P53 specific inhibitor (pifithrin-alpha) switches this response to RIP3-mediated necroptosis.	pifithrin	187-196	myosin phosphatase Rho interacting protein	Homo sapiens	230-234
28691888-10	2017	The p53 inhibitor, Pifithrin-alpha, blocked the gingipain-induced Bid.	pifithrin	19-34	tumor protein p53	Homo sapiens	4-7
28691888-10	2017	The p53 inhibitor, Pifithrin-alpha, blocked the gingipain-induced Bid.	pifithrin	19-34	BH3 interacting domain death agonist	Homo sapiens	66-69
28762569-6	2017	Interestingly, p53 and cleaved Caspase3 expressions were enhanced in the cells and reduced proliferation as well as cell death of Gabpa-null ESCs were rescued by either transfection of p53 RNAi or treatment of the p53 inhibitor pifithrin-alpha.	pifithrin	228-243	transformation related protein 53, pseudogene	Mus musculus	15-18
28762569-6	2017	Interestingly, p53 and cleaved Caspase3 expressions were enhanced in the cells and reduced proliferation as well as cell death of Gabpa-null ESCs were rescued by either transfection of p53 RNAi or treatment of the p53 inhibitor pifithrin-alpha.	pifithrin	228-243	caspase 3	Mus musculus	31-39
28762569-6	2017	Interestingly, p53 and cleaved Caspase3 expressions were enhanced in the cells and reduced proliferation as well as cell death of Gabpa-null ESCs were rescued by either transfection of p53 RNAi or treatment of the p53 inhibitor pifithrin-alpha.	pifithrin	228-243	GA repeat binding protein, alpha	Mus musculus	130-135
32719725-5	2017	Further study showed that TFS decreased mitochondrial membrane potential, activated Caspase-3/7, Caspase-8 and Caspase-9 activities, and that the p53 inhibitor PFT-alpha reversed the TFS-induced cell growth inhibition and apoptosis.	pifithrin	160-169	caspase 8	Homo sapiens	97-106
32719725-5	2017	Further study showed that TFS decreased mitochondrial membrane potential, activated Caspase-3/7, Caspase-8 and Caspase-9 activities, and that the p53 inhibitor PFT-alpha reversed the TFS-induced cell growth inhibition and apoptosis.	pifithrin	160-169	caspase 9	Homo sapiens	111-120
32719725-5	2017	Further study showed that TFS decreased mitochondrial membrane potential, activated Caspase-3/7, Caspase-8 and Caspase-9 activities, and that the p53 inhibitor PFT-alpha reversed the TFS-induced cell growth inhibition and apoptosis.	pifithrin	160-169	tumor protein p53	Homo sapiens	146-149
28663058-7	2017	This loss of cells could be ameliorated by simultaneous treatment with the P53 inhibitor, Pifithrin-alpha.	pifithrin	90-105	transformation related protein 53, pseudogene	Mus musculus	75-78
29246013-5	2017	Therefore, PFTalpha, a p53 inhibitor, was introduced in this study to block the ethanol-triggered activation of p53 in hBMSCs and alcohol-induced ONFH in a rat model.	pifithrin	11-19	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	112-115
27194299-13	2017	Finally, p53 activator (actinomycin D) and inhibitor (pifithrin-alpha) attenuated and potentiated the isoflurane-induced increase in gammaH2A.X level, respectively.	pifithrin	54-63	transformation related protein 53, pseudogene	Mus musculus	9-12
28431961-7	2017	Senescence was significantly inhibited by treatment with pifithrin-alpha, a p53 inhibitor, or by MnTBAP, a superoxide dismutase mimetic, validating those molecular actors in IR-induced endothelial cell aging.	pifithrin	57-66	tumor protein p53	Homo sapiens	76-79
28489093-5	2017	In vitro functional studies demonstrated that the PFTalpha molecules exhibited potent ability to induce osteogenesis of hBMSCs via the GSK3beta/beta-catenin pathway, and the LDH-CS-PFTalpha scaffolds significantly enhanced the osteogenic differentiation of hBMSCs.	pifithrin	50-58	glycogen synthase kinase 3 beta	Rattus norvegicus	135-143
28320710-6	2017	Using the stasis model of venous thrombosis and resolution in mice, we found that genetic deficiency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and is associated with increased fibrosis and altered expression of matrix metalloproteinase-2.	pifithrin	139-148	transformation related protein 53, pseudogene	Mus musculus	104-107
28320710-6	2017	Using the stasis model of venous thrombosis and resolution in mice, we found that genetic deficiency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and is associated with increased fibrosis and altered expression of matrix metalloproteinase-2.	pifithrin	139-148	matrix metallopeptidase 2	Mus musculus	245-271
28631571-14	2017	The above-mentioned characteristics were reverted by treatment of with pifithrin-a, a p53 inhibitor.	pifithrin	71-82	tumor protein p53	Homo sapiens	86-89
28489093-5	2017	In vitro functional studies demonstrated that the PFTalpha molecules exhibited potent ability to induce osteogenesis of hBMSCs via the GSK3beta/beta-catenin pathway, and the LDH-CS-PFTalpha scaffolds significantly enhanced the osteogenic differentiation of hBMSCs.	pifithrin	50-58	catenin beta 1	Rattus norvegicus	144-156
28143426-9	2017	The impact of functional p53 was investigated by siRNA gene silencing and the p53 inhibitor pifithrin-alpha.	pifithrin	92-107	tumor protein p53	Homo sapiens	25-28
28237798-9	2017	After treatment of CSCI in rats with Pifithrin-mu(PFT-mu), a specific inhibitor of p53, pathomorphological changes of myelin sheath improved significantly.	pifithrin	37-46	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	83-86
32263615-7	2017	Note that the PFTalpha released from the PFTalpha-LDH-CS rapidly improved the cell proliferation, ALP activity, ECM mineralization and protein level of the Runt-related transcription factor 2 (RUNX2) and beta-catenin.	pifithrin	14-22	ATHS	Homo sapiens	98-101
32263615-7	2017	Note that the PFTalpha released from the PFTalpha-LDH-CS rapidly improved the cell proliferation, ALP activity, ECM mineralization and protein level of the Runt-related transcription factor 2 (RUNX2) and beta-catenin.	pifithrin	14-22	RUNX family transcription factor 2	Homo sapiens	156-191
32263615-7	2017	Note that the PFTalpha released from the PFTalpha-LDH-CS rapidly improved the cell proliferation, ALP activity, ECM mineralization and protein level of the Runt-related transcription factor 2 (RUNX2) and beta-catenin.	pifithrin	14-22	RUNX family transcription factor 2	Homo sapiens	193-198
32263615-7	2017	Note that the PFTalpha released from the PFTalpha-LDH-CS rapidly improved the cell proliferation, ALP activity, ECM mineralization and protein level of the Runt-related transcription factor 2 (RUNX2) and beta-catenin.	pifithrin	14-22	catenin beta 1	Homo sapiens	204-216
32263615-8	2017	The enhanced osteogenic differentiation of hBMSCs on the PFTalpha-LDH-CS may be attributed to the PFTalpha released from the abovementioned nanohybrid composites, which resulted in the accumulation of beta-catenin and activation of the beta-catenin-mediated transcription activity in the cell nucleus.	pifithrin	57-65	catenin beta 1	Homo sapiens	201-213
32263615-8	2017	The enhanced osteogenic differentiation of hBMSCs on the PFTalpha-LDH-CS may be attributed to the PFTalpha released from the abovementioned nanohybrid composites, which resulted in the accumulation of beta-catenin and activation of the beta-catenin-mediated transcription activity in the cell nucleus.	pifithrin	57-65	catenin beta 1	Homo sapiens	236-248
28098861-10	2017	Treatment of HepG2 cells with p53 inhibitor, pifithrin-alpha prior to incubation with triptolide significantly prevented induction of cell apoptosis.	pifithrin	45-60	tumor protein p53	Homo sapiens	30-33
28028695-9	2017	An increase in p53 levels was detected following 5-FU treatment; pifithrin-alpha, an inhibitor of p53 activation, reversed 5-FU-induced SESN2 expression.	pifithrin	65-74	tumor protein p53	Homo sapiens	15-18
28028695-9	2017	An increase in p53 levels was detected following 5-FU treatment; pifithrin-alpha, an inhibitor of p53 activation, reversed 5-FU-induced SESN2 expression.	pifithrin	65-74	tumor protein p53	Homo sapiens	98-101
28028695-9	2017	An increase in p53 levels was detected following 5-FU treatment; pifithrin-alpha, an inhibitor of p53 activation, reversed 5-FU-induced SESN2 expression.	pifithrin	65-74	sestrin 2	Homo sapiens	136-141
28143426-9	2017	The impact of functional p53 was investigated by siRNA gene silencing and the p53 inhibitor pifithrin-alpha.	pifithrin	92-107	tumor protein p53	Homo sapiens	78-81
27879267-2	2017	Prompted by the hypothesis that neuronal mitochondrial dysfunction underlies chemotherapy-induced cognitive impairment (CICI), we explored the efficacy of administering the small-molecule pifithrin (PFT)-mu, an inhibitor of mitochondrial p53 accumulation, in preventing CICI.	pifithrin	188-197	transformation related protein 53, pseudogene	Mus musculus	238-241
28035355-9	2017	Additionally, suppression of p53 using a specific inhibitor, pifithrin-alpha, abrogated the pro-apoptotic effects of Scutellarin in HCT-116 cells.	pifithrin	61-76	tumor protein p53	Homo sapiens	29-32
28145533-6	2017	Wortmannin (PI-3Kinases inhibitor), SP600125 (JNK inhibitor) and pifithrin-alpha (p53 inhibitor) abrogated curcumin-mediated induction of Bex genes.	pifithrin	65-80	transformation related protein 53, pseudogene	Mus musculus	82-85
28321407-7	2017	When using Pifithrin-alpha (one of p53 inhibitors), the level of p53-dependent apoptosis was significantly lower than untreated, which suggested that p53 was possibly involved in PTEN-dependent apoptosis.	pifithrin	11-26	tumor protein p53	Homo sapiens	35-38
27766434-10	2017	Finally, using pifithrin alpha we observed a decrease in apoptosis induced by MG132, and by APO-1 plus MG132, suggesting that restoration of APO-1 sensitivity occurs in part through an increase in both the levels and the activity of p53.	pifithrin	15-30	Fas cell surface death receptor	Homo sapiens	141-146
28321407-7	2017	When using Pifithrin-alpha (one of p53 inhibitors), the level of p53-dependent apoptosis was significantly lower than untreated, which suggested that p53 was possibly involved in PTEN-dependent apoptosis.	pifithrin	11-26	tumor protein p53	Homo sapiens	65-68
28321407-7	2017	When using Pifithrin-alpha (one of p53 inhibitors), the level of p53-dependent apoptosis was significantly lower than untreated, which suggested that p53 was possibly involved in PTEN-dependent apoptosis.	pifithrin	11-26	tumor protein p53	Homo sapiens	65-68
28321407-7	2017	When using Pifithrin-alpha (one of p53 inhibitors), the level of p53-dependent apoptosis was significantly lower than untreated, which suggested that p53 was possibly involved in PTEN-dependent apoptosis.	pifithrin	11-26	phosphatase and tensin homolog	Homo sapiens	179-183
27622990-8	2017	Inhibition of p53 with pifithrin-alpha or a dominant-negative mutant led to the repression of miR-17-5p expression under hypoxia in vitro.	pifithrin	23-38	transformation related protein 53, pseudogene	Mus musculus	14-17
28405636-7	2016	Treatment with noribogaine and/or HSP70 inhibitor pifithrin-mu restored folding of, and dopamine transport by, dDAT-G108Q, its axonal delivery and normal sleep time in mutant flies.	pifithrin	50-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
27748853-9	2016	PTE resulted in a significant decrease in SOD2 expression in liver tumor tissues and cells, which were inhibited by PFTalpha, but not NAC, indicating that PTE-induced ROS generation was attributed to p53-mediated downregulation of SOD2.	pifithrin	116-124	superoxide dismutase 2, mitochondrial	Mus musculus	231-235
27553877-4	2016	Our previous studies demonstrated that a p53 inhibitor, pifithrin-alpha oxygen analogue (PFT-alpha (O)), significantly reduced cortical cell death, which is substantial following controlled cortical impact (CCI) TBI, and improved neurological functional outcomes via anti-apoptotic mechanisms.	pifithrin	56-65	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	41-44
27327234-6	2016	Pifithrin-alpha (PFT), an inhibitor of p53, significantly enhanced ARS-induced cytotoxicity in HepG2 cells, and the forced expression of wild-type p53 significantly enhanced ARS-induced cytotoxicity in Hep3B cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	39-42
27869678-1	2016	Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-mu.	pifithrin	45-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	28-33
26563498-7	2016	MPPE, selegiline, or pifithrin-mu significantly attenuated mitochondrial p53/Bcl-xL interaction, impaired mitochondrial transmembrane potential, cytosolic cytochrome c release, and cleaved caspase-3 in wild-type mice.	pifithrin	21-30	transformation related protein 53, pseudogene	Mus musculus	73-76
26563498-7	2016	MPPE, selegiline, or pifithrin-mu significantly attenuated mitochondrial p53/Bcl-xL interaction, impaired mitochondrial transmembrane potential, cytosolic cytochrome c release, and cleaved caspase-3 in wild-type mice.	pifithrin	21-30	BCL2-like 1	Mus musculus	77-83
27829991-4	2016	Pifithrin-alpha, a p53 inhibitor, was administered at 24 h before renal ischemia and 3 and 14 days after reperfusion.	pifithrin	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	19-22
27829991-8	2016	Cells treated with TNF-alpha alone in G2/M phase increased significantly, but they were reduced in the presence of pifithrin-alpha.	pifithrin	115-130	tumor necrosis factor	Rattus norvegicus	19-28
27829991-9	2016	In NRK-52E cells treated with pifithrin-alpha for 6 h, NGAL mRNA expression was significantly lower than in cells without pifithrin-alpha treatment.	pifithrin	30-39	lipocalin 2	Rattus norvegicus	55-59
27748853-9	2016	PTE resulted in a significant decrease in SOD2 expression in liver tumor tissues and cells, which were inhibited by PFTalpha, but not NAC, indicating that PTE-induced ROS generation was attributed to p53-mediated downregulation of SOD2.	pifithrin	116-124	superoxide dismutase 2, mitochondrial	Mus musculus	42-46
27748853-9	2016	PTE resulted in a significant decrease in SOD2 expression in liver tumor tissues and cells, which were inhibited by PFTalpha, but not NAC, indicating that PTE-induced ROS generation was attributed to p53-mediated downregulation of SOD2.	pifithrin	116-124	transformation related protein 53, pseudogene	Mus musculus	200-203
27471307-9	2016	P53 and p21 expression were upregulated in MSC-ITP, but inhibition of p53 with pifithrin-alpha markedly inhibited apoptosis and senescence.	pifithrin	79-94	tumor protein p53	Homo sapiens	70-73
27395830-0	2016	Functional inhibition of Hsp70 by Pifithrin-mu switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells.	pifithrin	34-43	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
27395830-5	2016	We observed that functional inhibition of Hsp70 by Pifithrin-mu switches GA induced caspase dependent (apoptotic) cell death to caspase independent cell death.	pifithrin	51-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	42-47
27395830-7	2016	Inhibition of Hsp70 by Pifithrin-mu shows differential effect on MMP.	pifithrin	23-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
27395830-8	2016	GA induced MMP and cytochrome-c release was inhibited by Pifithrin-mu at 12h but enhanced at 24h.	pifithrin	57-66	cytochrome c, somatic	Homo sapiens	19-31
27555286-6	2016	Specific inhibition of p53 by pifithrin-alpha reversed the G2/M phase arrest induced by the 2b compound, suggesting contribution of p53 to increase.	pifithrin	30-39	tumor protein p53	Homo sapiens	23-26
27327234-6	2016	Pifithrin-alpha (PFT), an inhibitor of p53, significantly enhanced ARS-induced cytotoxicity in HepG2 cells, and the forced expression of wild-type p53 significantly enhanced ARS-induced cytotoxicity in Hep3B cells.	pifithrin	17-20	tumor protein p53	Homo sapiens	39-42
27402273-12	2016	Pifithrin-alpha, a p53 inhibitor, slightly inhibited growth of A549 cells and under p53 inhibitory condition evodiamine-induced apoptosis could not be reversed.	pifithrin	0-15	tumor protein p53	Homo sapiens	19-22
27591796-8	2016	Increased Nrf2 expression and catalase activity at 40 C were inhibited by the antioxidant PEG-catalase and by p53 inhibitor pifithrin-alpha.	pifithrin	124-139	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
27591796-8	2016	Increased Nrf2 expression and catalase activity at 40 C were inhibited by the antioxidant PEG-catalase and by p53 inhibitor pifithrin-alpha.	pifithrin	124-139	catalase	Homo sapiens	30-38
27591796-8	2016	Increased Nrf2 expression and catalase activity at 40 C were inhibited by the antioxidant PEG-catalase and by p53 inhibitor pifithrin-alpha.	pifithrin	124-139	tumor protein p53	Homo sapiens	110-113
27481941-2	2016	Here, we provide a proof-of-principle that the folding deficit is amenable to correction in vivo by two means, the cognate DAT ligand noribogaine and the HSP70 inhibitor, pifithrin-mu.	pifithrin	171-180	Heat-shock-protein-70Ab	Drosophila melanogaster	154-159
27402273-12	2016	Pifithrin-alpha, a p53 inhibitor, slightly inhibited growth of A549 cells and under p53 inhibitory condition evodiamine-induced apoptosis could not be reversed.	pifithrin	0-15	tumor protein p53	Homo sapiens	84-87
27455212-0	2016	Novel Improved Synthesis of HSP70 Inhibitor, Pifithrin-mu.	pifithrin	45-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	28-33
27470413-10	2016	Moreover, the inhibiting effects and apoptotic related proteins responses to Ch-1 on Hela cells were abolished after pre-treated with Pifithrin-alpha (Pft-alpha), a p53 inhibitor.	pifithrin	134-149	SUN domain containing ossification factor	Homo sapiens	77-81
27470413-10	2016	Moreover, the inhibiting effects and apoptotic related proteins responses to Ch-1 on Hela cells were abolished after pre-treated with Pifithrin-alpha (Pft-alpha), a p53 inhibitor.	pifithrin	134-149	tumor protein p53	Homo sapiens	165-168
27133769-8	2016	Pharmacological inhibition of p53 with pifithrin-alpha attenuated caspase-3 activation.	pifithrin	39-48	transformation related protein 53, pseudogene	Mus musculus	30-33
27455212-3	2016	The first example of a combination study comprising HSP70 inhibitor pifithrin-mu and cisplatin or oxaliplatin is reported.	pifithrin	68-77	heat shock protein family A (Hsp70) member 4	Homo sapiens	52-57
26250568-5	2015	When cells were pretreated with a p53 inhibitor (pifithrin-a), followed by magnolol treatment, pifithrin-a blocked magnolol-induced apoptosis and G0 /G1 arrest.	pifithrin	95-106	tumor protein p53	Homo sapiens	34-37
27270209-8	2016	Inhibition of p53 by pifithrin-alpha, attenuates citral-mediated apoptosis.	pifithrin	21-36	tumor protein p53	Homo sapiens	14-17
27064011-5	2016	Pifithrin-alpha (PFN-alpha), a p53 inhibitor, was pretreated into the cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	31-34
26784190-10	2016	Furthermore, pifithrin-alpha, a specific inhibitor of p53, increased mitochondrial incorporation into autophagosomes.	pifithrin	13-28	transformation related protein 53, pseudogene	Mus musculus	54-57
26636375-3	2016	In the present study by using the specific inhibitors Ku55933 and Pifithrin-alpha, we confirmed implication of both ATM and p53 in H(2)O(2)-induced senescence of hMESCs.	pifithrin	66-75	ATM serine/threonine kinase	Homo sapiens	116-119
26636375-3	2016	In the present study by using the specific inhibitors Ku55933 and Pifithrin-alpha, we confirmed implication of both ATM and p53 in H(2)O(2)-induced senescence of hMESCs.	pifithrin	66-75	tumor protein p53	Homo sapiens	124-127
26881748-3	2016	This study aims at investigating the potential effect of pifithrin-mu, an inhibitor of heat shock protein 70 substrate binding activity, on lipopolysaccharide (LPS)-induced sickness response.	pifithrin	57-66	toll-like receptor 4	Mus musculus	160-163
26881748-11	2016	Pretreatment with pifithrin-mu (1 or 5 mg/kg) attenuated behavioral changes induced by LPS in the FST, TST, OFT and light-dark box test.	pifithrin	18-27	toll-like receptor 4	Mus musculus	87-90
26434996-6	2015	The energy metabolism phenotype of HeLa-H cells was reverted to that of HeLa-L cells by incubating with pifithrin-alpha, a p53-inhibitor.	pifithrin	104-119	tumor protein p53	Homo sapiens	123-126
26703711-4	2015	The application of pifithrin mu as an inhibitor of p53 shuttling to mitochondria reduced RV-induced cell death to an extent similar to that of the broad spectrum caspase inhibitor z-VAD-fmk (benzyloxycarbonyl-V-A-D-(OMe)-fmk).	pifithrin	19-28	tumor protein p53	Homo sapiens	51-54
26250568-5	2015	When cells were pretreated with a p53 inhibitor (pifithrin-a), followed by magnolol treatment, pifithrin-a blocked magnolol-induced apoptosis and G0 /G1 arrest.	pifithrin	49-60	tumor protein p53	Homo sapiens	34-37
27212231-0	2016	Regenerative repair of Pifithrin-alpha in cerebral ischemia via VEGF dependent manner.	pifithrin	23-38	vascular endothelial growth factor A	Rattus norvegicus	64-68
27016419-7	2016	Inhibiting p53 activity by pifithrin-` dramatically mitigated Numb-induced G2/M arrest, indicating that Numb potentiates G2/M arrest via stabilizing p53 protein.	pifithrin	27-36	transformation related protein 53, pseudogene	Mus musculus	11-14
27016419-7	2016	Inhibiting p53 activity by pifithrin-` dramatically mitigated Numb-induced G2/M arrest, indicating that Numb potentiates G2/M arrest via stabilizing p53 protein.	pifithrin	27-36	NUMB endocytic adaptor protein	Mus musculus	62-66
27016419-7	2016	Inhibiting p53 activity by pifithrin-` dramatically mitigated Numb-induced G2/M arrest, indicating that Numb potentiates G2/M arrest via stabilizing p53 protein.	pifithrin	27-36	NUMB endocytic adaptor protein	Mus musculus	104-108
27016419-7	2016	Inhibiting p53 activity by pifithrin-` dramatically mitigated Numb-induced G2/M arrest, indicating that Numb potentiates G2/M arrest via stabilizing p53 protein.	pifithrin	27-36	transformation related protein 53, pseudogene	Mus musculus	149-152
26291498-0	2016	The p53 inhibitor, pifithrin-alpha, disrupts microtubule organization, arrests growth, and induces polyploidy in the rainbow trout gill cell line, RTgill-W1.	pifithrin	19-34	cellular tumor antigen p53	Oncorhynchus mykiss	4-7
26534988-6	2016	Treatment with pifithrin-mu and transfection with anti-CHIP small-interfering RNA reduced the levels of CYP3A4 mRNA induced by rifampicin, suggesting the contribution of Hsp70 and CHIP to the transactivation of hPXR.	pifithrin	15-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	104-110
26534988-6	2016	Treatment with pifithrin-mu and transfection with anti-CHIP small-interfering RNA reduced the levels of CYP3A4 mRNA induced by rifampicin, suggesting the contribution of Hsp70 and CHIP to the transactivation of hPXR.	pifithrin	15-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	170-175
26534988-6	2016	Treatment with pifithrin-mu and transfection with anti-CHIP small-interfering RNA reduced the levels of CYP3A4 mRNA induced by rifampicin, suggesting the contribution of Hsp70 and CHIP to the transactivation of hPXR.	pifithrin	15-24	nuclear receptor subfamily 1 group I member 2	Homo sapiens	211-215
26523514-6	2015	Moreover, this phosphorylation was completely blocked by pre-treatment with a P53 inhibitor, pifithrin-alpha.	pifithrin	93-108	transformation related protein 53, pseudogene	Mus musculus	78-81
26473292-6	2015	We have shown earlier that inhibition of mitochondrial p53 accumulation with the small compound pifithrin-mu (PFT-mu) prevents cerebral neuronal death in a rodent model of hypoxic-ischemic brain damage.	pifithrin	96-105	transformation related protein 53, pseudogene	Mus musculus	55-58
26302161-6	2015	Inhibition of p53 activity using either pifithrin-alpha or small interference RNA interference reduced OGD-induced cell death and pifithrin-alpha reversed OGD-induced impairment of glutamate uptake in astrocytes, suggesting that p53 might play a key role in mediating neurotoxicity and gliotoxicity in ischemic brain injury.	pifithrin	40-49	tumor protein p53	Homo sapiens	14-17
26302161-6	2015	Inhibition of p53 activity using either pifithrin-alpha or small interference RNA interference reduced OGD-induced cell death and pifithrin-alpha reversed OGD-induced impairment of glutamate uptake in astrocytes, suggesting that p53 might play a key role in mediating neurotoxicity and gliotoxicity in ischemic brain injury.	pifithrin	130-139	tumor protein p53	Homo sapiens	14-17
25016051-8	2015	Systemic pifithrin-alpha administration considerably diminished p53 levels and ameliorated AKT phosphorylation in all peripheral tissues including adipose tissues.	pifithrin	9-24	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	64-67
26121334-3	2015	We therefore explored the involvement of p53 in the monocrotaline (MCT) rat model of pulmonary hypertension (PH) and the pathophysiological consequences of p53 inactivation in response to animal treatment with pifithrin-alpha (PFT, an inhibitor of p53 activity).	pifithrin	210-225	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	156-159
26121334-3	2015	We therefore explored the involvement of p53 in the monocrotaline (MCT) rat model of pulmonary hypertension (PH) and the pathophysiological consequences of p53 inactivation in response to animal treatment with pifithrin-alpha (PFT, an inhibitor of p53 activity).	pifithrin	210-225	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	156-159
25955698-8	2015	Pre-treatment with the p53 inhibitor, pifithrin-alpha, prevented apoptosis and the changes in IGF-1R and IGFBP-3 elicited by doxorubicin.	pifithrin	38-47	tumor protein p53	Homo sapiens	23-26
25955698-8	2015	Pre-treatment with the p53 inhibitor, pifithrin-alpha, prevented apoptosis and the changes in IGF-1R and IGFBP-3 elicited by doxorubicin.	pifithrin	38-47	insulin like growth factor 1 receptor	Homo sapiens	94-100
25955698-8	2015	Pre-treatment with the p53 inhibitor, pifithrin-alpha, prevented apoptosis and the changes in IGF-1R and IGFBP-3 elicited by doxorubicin.	pifithrin	38-47	insulin like growth factor binding protein 3	Homo sapiens	105-112
25793965-5	2015	The 1-induced degradation of beta-catenin was also abrogated in the presence of pifithrin-alpha, an inhibitor of p53 transcriptional activity.	pifithrin	80-95	catenin beta 1	Homo sapiens	29-41
25793965-5	2015	The 1-induced degradation of beta-catenin was also abrogated in the presence of pifithrin-alpha, an inhibitor of p53 transcriptional activity.	pifithrin	80-95	tumor protein p53	Homo sapiens	113-116
25713322-6	2015	A similar effect was induced by the p53 inhibitor pifithrin, which also potentiated the LPS-induced hyperpermeability in human lung microvascular endothelial cells (HLMVEC).	pifithrin	50-59	tumor protein p53	Homo sapiens	36-39
26170659-13	2015	Cells pretreated with pifithrin-alpha were protected from p53-mediated AgNPs-induced toxicity.	pifithrin	22-37	tumor protein p53	Homo sapiens	58-61
25938491-9	2015	Specific inhibition of p53 by pifithrin-alpha reduces the percentage of cells accumulated in S-phase, suggesting contribution of p53 to S-phase increase.	pifithrin	30-45	tumor protein p53	Homo sapiens	23-26
25742798-7	2015	Injection of pifithrin-alpha, a chemical inhibitor of p53, into pregnant mice prevented neonatal lethality while concomitantly reducing apoptosis in nasal cartilage primordia, suggesting that enhanced BMP signaling induces p53-mediated apoptosis in the nasal cartilage.	pifithrin	13-28	transformation related protein 53	Mus musculus	54-57
25742798-7	2015	Injection of pifithrin-alpha, a chemical inhibitor of p53, into pregnant mice prevented neonatal lethality while concomitantly reducing apoptosis in nasal cartilage primordia, suggesting that enhanced BMP signaling induces p53-mediated apoptosis in the nasal cartilage.	pifithrin	13-28	transformation related protein 53	Mus musculus	223-226
25575314-3	2015	While pifithrin-alpha, a specific p53 inhibitor, induced cell cycle arrest in G1 phase.	pifithrin	6-21	tumor protein p53	Homo sapiens	34-37
25483559-6	2015	In accordance with this effect, when the acetylation level of p53 was decreased by p53 acetylation inhibitor pifithrin-alpha, the protective effects of resveratrol were abrogated.	pifithrin	109-124	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	62-65
25483559-6	2015	In accordance with this effect, when the acetylation level of p53 was decreased by p53 acetylation inhibitor pifithrin-alpha, the protective effects of resveratrol were abrogated.	pifithrin	109-124	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	83-86
25542456-5	2015	Pretreatment with pifithrin-alpha, a p53 inhibitor, downregulated active p53 in two-cell embryo nuclei and ameliorated approximately 50% of the embryonic developmental defect caused by resveratrol.	pifithrin	18-33	transformation related protein 53, pseudogene	Mus musculus	37-40
25542456-5	2015	Pretreatment with pifithrin-alpha, a p53 inhibitor, downregulated active p53 in two-cell embryo nuclei and ameliorated approximately 50% of the embryonic developmental defect caused by resveratrol.	pifithrin	18-33	transformation related protein 53, pseudogene	Mus musculus	73-76
25575314-4	2015	Although 1, 2 and pifithrin-alpha caused serious inhibition on p53, 1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells.	pifithrin	18-27	tumor protein p53	Homo sapiens	63-75
25575314-4	2015	Although 1, 2 and pifithrin-alpha caused serious inhibition on p53, 1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells.	pifithrin	18-27	cytochrome c, somatic	Homo sapiens	192-204
25575314-4	2015	Although 1, 2 and pifithrin-alpha caused serious inhibition on p53, 1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells.	pifithrin	18-27	apoptotic peptidase activating factor 1	Homo sapiens	206-212
25575314-4	2015	Although 1, 2 and pifithrin-alpha caused serious inhibition on p53, 1 and 2 significantly cause the loss of mitochondrial membrane potential and increase of the reactive oxygen species level, cytochrome c, apaf-1 and caspase-3/9 ratio in BEL-7404 cells.	pifithrin	18-27	caspase 3	Homo sapiens	217-226
25658320-7	2015	To a different extent, either the antioxidant N-acetyl-cysteine or the p53 inhibitor, Pifithrin-alpha, recover cell viability and decrease ROS formation.	pifithrin	86-101	tumor protein p53	Homo sapiens	71-74
25533125-6	2015	In addition, SUMOylation by SUMO-2/3, but not SUMO-1, was partially suppressed by pifithrin-alpha (a pharmacological inhibitor of p53), supporting a role of p53 in SUMOylation by SUMO-2/3.	pifithrin	82-97	small ubiquitin-like modifier 2	Rattus norvegicus	28-36
25533125-6	2015	In addition, SUMOylation by SUMO-2/3, but not SUMO-1, was partially suppressed by pifithrin-alpha (a pharmacological inhibitor of p53), supporting a role of p53 in SUMOylation by SUMO-2/3.	pifithrin	82-97	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	130-133
25533125-6	2015	In addition, SUMOylation by SUMO-2/3, but not SUMO-1, was partially suppressed by pifithrin-alpha (a pharmacological inhibitor of p53), supporting a role of p53 in SUMOylation by SUMO-2/3.	pifithrin	82-97	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	157-160
25533125-6	2015	In addition, SUMOylation by SUMO-2/3, but not SUMO-1, was partially suppressed by pifithrin-alpha (a pharmacological inhibitor of p53), supporting a role of p53 in SUMOylation by SUMO-2/3.	pifithrin	82-97	small ubiquitin-like modifier 2	Rattus norvegicus	28-34
25641429-5	2015	Furthermore, the enhancement of p53-dependent apoptosis by flavokawain B could be rescued by pifithrin-alpha, a pharmacological inhibitor of p53 transcriptional activity.	pifithrin	93-108	tumor protein p53	Homo sapiens	32-35
25737737-6	2015	Treatment of cells with pifithrin-alpha, a specific inhibitor of p53, suppressed shikonin-induced apoptosis and premature senescence, suggesting the role of p53 in mediating the actions of shikonin on regulation of lung cancer cell proliferation.	pifithrin	24-39	tumor protein p53	Homo sapiens	65-68
25737737-6	2015	Treatment of cells with pifithrin-alpha, a specific inhibitor of p53, suppressed shikonin-induced apoptosis and premature senescence, suggesting the role of p53 in mediating the actions of shikonin on regulation of lung cancer cell proliferation.	pifithrin	24-39	tumor protein p53	Homo sapiens	157-160
25544361-8	2015	These effects were blocked by pretreatment with pifithrin-alpha, a p53 inhibitor.	pifithrin	48-63	tumor protein p53	Homo sapiens	67-70
24963915-7	2015	Moreover, blockade of p53 by pifithrin-alpha, siRNA, or proximal tubule-targeted gene ablation reduced ischemic AKI in diabetic mice.	pifithrin	29-38	transformation related protein 53, pseudogene	Mus musculus	22-25
25641429-5	2015	Furthermore, the enhancement of p53-dependent apoptosis by flavokawain B could be rescued by pifithrin-alpha, a pharmacological inhibitor of p53 transcriptional activity.	pifithrin	93-108	tumor protein p53	Homo sapiens	141-144
25435953-15	2015	Subsequent to the use of Pifithrin-alpha, a specific inhibitor of p53 activation, increased MDM2 expression was observed in the LIRR1-overexpressing cells, suggesting that LIRR1 could mediate the DNA damage response (DDR) signaling in a p53-dependent manner.	pifithrin	25-40	tumor protein p53	Homo sapiens	66-69
25435953-15	2015	Subsequent to the use of Pifithrin-alpha, a specific inhibitor of p53 activation, increased MDM2 expression was observed in the LIRR1-overexpressing cells, suggesting that LIRR1 could mediate the DNA damage response (DDR) signaling in a p53-dependent manner.	pifithrin	25-40	MDM2 proto-oncogene	Homo sapiens	92-96
25435953-15	2015	Subsequent to the use of Pifithrin-alpha, a specific inhibitor of p53 activation, increased MDM2 expression was observed in the LIRR1-overexpressing cells, suggesting that LIRR1 could mediate the DNA damage response (DDR) signaling in a p53-dependent manner.	pifithrin	25-40	tumor protein p53	Homo sapiens	237-240
25565771-9	2015	Pifithrin-alpha, a p53 inhibitor, blocked the modulation of As4S4 on AGS cells, but not on MGC803 cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	19-22
25019212-4	2014	This indicates p53-independent apoptotic pathway, because response of both p53 mutant and wild type cell line were found unaffected after treatment with pifithrin-alpha, an inhibitor of p53.	pifithrin	153-168	tumor protein p53	Homo sapiens	15-18
25495224-3	2014	RESULTS: The effect of IL-1beta, but not of TNF-alpha, on glutamate-mediated excitatory postsynaptic currents was blocked by pifithrin-alpha (PFT), inhibitor of p53.	pifithrin	125-140	interleukin 1 beta	Homo sapiens	23-31
25495224-3	2014	RESULTS: The effect of IL-1beta, but not of TNF-alpha, on glutamate-mediated excitatory postsynaptic currents was blocked by pifithrin-alpha (PFT), inhibitor of p53.	pifithrin	125-140	tumor protein p53	Homo sapiens	161-164
26579413-5	2014	The combination also decreased the MMP, down-regulated Bcl-2 and pro-proteins of the caspase family, and up-regulated Bax and BID, all of which were reversed by the p53 inhibitor, pifithrin-alpha.	pifithrin	180-189	BCL2 apoptosis regulator	Homo sapiens	55-60
26579413-5	2014	The combination also decreased the MMP, down-regulated Bcl-2 and pro-proteins of the caspase family, and up-regulated Bax and BID, all of which were reversed by the p53 inhibitor, pifithrin-alpha.	pifithrin	180-189	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
26579413-5	2014	The combination also decreased the MMP, down-regulated Bcl-2 and pro-proteins of the caspase family, and up-regulated Bax and BID, all of which were reversed by the p53 inhibitor, pifithrin-alpha.	pifithrin	180-189	BH3 interacting domain death agonist	Homo sapiens	126-129
26579413-5	2014	The combination also decreased the MMP, down-regulated Bcl-2 and pro-proteins of the caspase family, and up-regulated Bax and BID, all of which were reversed by the p53 inhibitor, pifithrin-alpha.	pifithrin	180-189	tumor protein p53	Homo sapiens	165-168
25158131-3	2014	Pifithrin-alpha, an inhibitor of p53 function, and knockdown of p53 decreased the level of frataxin mRNA in human kidney HEK 293T cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	33-36
25158131-3	2014	Pifithrin-alpha, an inhibitor of p53 function, and knockdown of p53 decreased the level of frataxin mRNA in human kidney HEK 293T cells.	pifithrin	0-15	frataxin	Homo sapiens	91-99
25329663-8	2014	Moreover, pre-treatment with pifithrin-alpha, a p53 inhibitor, inhibited protein synthesis almost completely, revealing the possibility of preventing fetal brain damage by prophylactic pifithrin-alpha treatment.	pifithrin	29-38	transformation related protein 53, pseudogene	Mus musculus	48-51
25085902-6	2014	Enhanced cytotoxicities after treatment with the p53-inhibitory drug Pifithrinalpha further supported p53-mediated resistance to PARP inhibition.	pifithrin	69-83	tumor protein p53	Homo sapiens	49-52
25085902-6	2014	Enhanced cytotoxicities after treatment with the p53-inhibitory drug Pifithrinalpha further supported p53-mediated resistance to PARP inhibition.	pifithrin	69-83	tumor protein p53	Homo sapiens	102-105
25118938-5	2014	Inhibition of p53 activity with pifithrin-alpha or inhibition of PI3K with LY294002 suppressed CdCl2-induced cellular damage and elevation of Notch1-NICD.	pifithrin	32-41	tumor protein p53	Homo sapiens	14-17
25085902-6	2014	Enhanced cytotoxicities after treatment with the p53-inhibitory drug Pifithrinalpha further supported p53-mediated resistance to PARP inhibition.	pifithrin	69-83	poly(ADP-ribose) polymerase 1	Homo sapiens	129-133
25084214-5	2014	In this work, we examined the effects of a cytoplasmic p53 inhibitor (pifithrin mu) in the striatum of young and aged rats by evaluating Ca(2+) signaling, mitochondrial respiration, apoptotic protein expression, and tissue viability.	pifithrin	70-79	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	55-58
25205311-10	2014	Pharmacological inhibition of mitochondrial p53 using pifithrin-mu abolished the detrimental effects of SI and reduced cell death.	pifithrin	54-63	tumor protein p53	Homo sapiens	44-47
24726874-15	2014	Down-regulated the expression of tumor suppressor p53 by 10 muM pifithrin-alpha (PFTalpha) alone had no effect on adipose accumulation.	pifithrin	64-79	tumor protein p53	Homo sapiens	50-53
24726874-15	2014	Down-regulated the expression of tumor suppressor p53 by 10 muM pifithrin-alpha (PFTalpha) alone had no effect on adipose accumulation.	pifithrin	81-89	tumor protein p53	Homo sapiens	50-53
24952138-8	2014	The p53 inhibitor pifithrin-alpha and the antioxidants N-acetylcysteine and glutathione (GSH) protected the cells from PEITC-mediated apoptosis.	pifithrin	18-33	tumor protein p53	Homo sapiens	4-7
24916697-7	2014	We found that pifithrin-alpha, an inhibitor of p53-dependent transcriptional activation, inhibits Oct2 and can mimic the lack of nephrotoxicity observed in p53(-/-)/Oct1/2(-/-)mice.	pifithrin	14-29	transformation related protein 53, pseudogene	Mus musculus	47-50
24916697-7	2014	We found that pifithrin-alpha, an inhibitor of p53-dependent transcriptional activation, inhibits Oct2 and can mimic the lack of nephrotoxicity observed in p53(-/-)/Oct1/2(-/-)mice.	pifithrin	14-29	POU domain, class 2, transcription factor 2	Mus musculus	98-102
24916697-7	2014	We found that pifithrin-alpha, an inhibitor of p53-dependent transcriptional activation, inhibits Oct2 and can mimic the lack of nephrotoxicity observed in p53(-/-)/Oct1/2(-/-)mice.	pifithrin	14-29	transformation related protein 53, pseudogene	Mus musculus	156-159
24916697-7	2014	We found that pifithrin-alpha, an inhibitor of p53-dependent transcriptional activation, inhibits Oct2 and can mimic the lack of nephrotoxicity observed in p53(-/-)/Oct1/2(-/-)mice.	pifithrin	14-29	POU domain, class 2, transcription factor 2	Mus musculus	165-180
28962260-8	2014	On the other hand, 1,3-DNP-induced apoptosis was inhibited by pifithrin-alpha, an inhibitor of p53 transcriptional activity.	pifithrin	62-77	transformation related protein 53, pseudogene	Mus musculus	95-98
24905957-7	2014	VIP effects could be blocked by cell incubation with a specific p53 inhibitor, cyclin pifithrin-alpha hydrobromide (CPFT-alphaH).	pifithrin	86-114	vasoactive intestinal peptide	Homo sapiens	0-3
24905957-7	2014	VIP effects could be blocked by cell incubation with a specific p53 inhibitor, cyclin pifithrin-alpha hydrobromide (CPFT-alphaH).	pifithrin	86-114	tumor protein p53	Homo sapiens	64-67
24667845-5	2014	Using pifithrin-alpha(PFT), a p53"s mitochondrial translocation inhibitor, we found that pretreated with PFT, heat stress induced mitochondrial p53 translocation was significantly suppressed, accompanied by a significant alleviation in the loss of DeltaPsim, cytochrome c release and caspase-9 activation.	pifithrin	6-21	tumor protein p53	Homo sapiens	30-33
24946211-9	2014	The anti-oxidant N-acetylcysteine (NAC), the P53 inhibitor pifithrin-alpha (PFTalpha) as well as P53 siRNA knockdown suppressed berberine-induced P53 mitochondrial translocation and Cyp-D association, thus inhibiting mitochondrial membrane potential (MMP) decrease and prostate cancer cell necrosis.	pifithrin	59-74	tumor protein p53	Homo sapiens	45-48
24946211-9	2014	The anti-oxidant N-acetylcysteine (NAC), the P53 inhibitor pifithrin-alpha (PFTalpha) as well as P53 siRNA knockdown suppressed berberine-induced P53 mitochondrial translocation and Cyp-D association, thus inhibiting mitochondrial membrane potential (MMP) decrease and prostate cancer cell necrosis.	pifithrin	59-74	peptidylprolyl isomerase F	Homo sapiens	182-187
24946211-9	2014	The anti-oxidant N-acetylcysteine (NAC), the P53 inhibitor pifithrin-alpha (PFTalpha) as well as P53 siRNA knockdown suppressed berberine-induced P53 mitochondrial translocation and Cyp-D association, thus inhibiting mitochondrial membrane potential (MMP) decrease and prostate cancer cell necrosis.	pifithrin	76-84	peptidylprolyl isomerase F	Homo sapiens	182-187
24948812-8	2014	The p53 inhibitor pifithrin abolished the SFN-induced increase in transporter activity/expression, and the p53-activator nutlin-3 increased P-glycoprotein activity.	pifithrin	18-27	transformation related protein 53, pseudogene	Mus musculus	4-7
24718323-11	2014	Finally, matrine treatment attenuated p53; however, with little or no change in LC3-II levels, but a decrease in beta-catenin levels occurred in WB-F344 cells upon treatment with pifithrin-alpha, a chemical inhibitor of p53, revealing that p53, interfering with beta-catenin, may not be involved in matrine-induced autophagy in WB-F344 cells.	pifithrin	179-194	catenin beta 1	Rattus norvegicus	113-125
24718323-11	2014	Finally, matrine treatment attenuated p53; however, with little or no change in LC3-II levels, but a decrease in beta-catenin levels occurred in WB-F344 cells upon treatment with pifithrin-alpha, a chemical inhibitor of p53, revealing that p53, interfering with beta-catenin, may not be involved in matrine-induced autophagy in WB-F344 cells.	pifithrin	179-194	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	220-223
24718323-11	2014	Finally, matrine treatment attenuated p53; however, with little or no change in LC3-II levels, but a decrease in beta-catenin levels occurred in WB-F344 cells upon treatment with pifithrin-alpha, a chemical inhibitor of p53, revealing that p53, interfering with beta-catenin, may not be involved in matrine-induced autophagy in WB-F344 cells.	pifithrin	179-194	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	220-223
24718323-11	2014	Finally, matrine treatment attenuated p53; however, with little or no change in LC3-II levels, but a decrease in beta-catenin levels occurred in WB-F344 cells upon treatment with pifithrin-alpha, a chemical inhibitor of p53, revealing that p53, interfering with beta-catenin, may not be involved in matrine-induced autophagy in WB-F344 cells.	pifithrin	179-194	catenin beta 1	Rattus norvegicus	262-274
24743574-12	2014	Moreover, Bcl-2 expression was completely reversed by treatment with pifithrin-alpha, a p53-specific inhibitor.	pifithrin	69-84	tumor protein p53	Homo sapiens	88-91
24789349-9	2014	Furthermore, p53 inhibition using pifithrin-alpha abolished the induction of caspase-3 and PARP by FANCF shRNA and MMC, indicating that MMC-induced apoptosis is substantially enhanced by FANCF shRNA via p53-dependent mechanisms.	pifithrin	34-43	tumor protein p53	Homo sapiens	13-16
24789349-9	2014	Furthermore, p53 inhibition using pifithrin-alpha abolished the induction of caspase-3 and PARP by FANCF shRNA and MMC, indicating that MMC-induced apoptosis is substantially enhanced by FANCF shRNA via p53-dependent mechanisms.	pifithrin	34-43	caspase 3	Homo sapiens	77-86
24789349-9	2014	Furthermore, p53 inhibition using pifithrin-alpha abolished the induction of caspase-3 and PARP by FANCF shRNA and MMC, indicating that MMC-induced apoptosis is substantially enhanced by FANCF shRNA via p53-dependent mechanisms.	pifithrin	34-43	poly(ADP-ribose) polymerase 1	Homo sapiens	91-95
24789349-9	2014	Furthermore, p53 inhibition using pifithrin-alpha abolished the induction of caspase-3 and PARP by FANCF shRNA and MMC, indicating that MMC-induced apoptosis is substantially enhanced by FANCF shRNA via p53-dependent mechanisms.	pifithrin	34-43	FA complementation group F	Homo sapiens	99-104
24789349-9	2014	Furthermore, p53 inhibition using pifithrin-alpha abolished the induction of caspase-3 and PARP by FANCF shRNA and MMC, indicating that MMC-induced apoptosis is substantially enhanced by FANCF shRNA via p53-dependent mechanisms.	pifithrin	34-43	FA complementation group F	Homo sapiens	187-192
24789349-9	2014	Furthermore, p53 inhibition using pifithrin-alpha abolished the induction of caspase-3 and PARP by FANCF shRNA and MMC, indicating that MMC-induced apoptosis is substantially enhanced by FANCF shRNA via p53-dependent mechanisms.	pifithrin	34-43	tumor protein p53	Homo sapiens	203-206
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pifithrin	28-37	tumor protein p53	Homo sapiens	14-17
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pifithrin	28-37	beclin 1	Homo sapiens	146-154
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pifithrin	28-37	cytochrome c, somatic	Homo sapiens	180-192
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pifithrin	28-37	caspase 3	Homo sapiens	202-211
24841907-6	2014	Moreover, the p53 inhibitor pifithrin-alpha and the nuclear factor (NF)-kappaB inhibitor pyrrolidinedithiocarbamic acid (PDTC) clearly suppressed Beclin-1 and LC3-II and increased cytochrome c release, caspase-3 activation, and PARP cleavage.	pifithrin	28-37	poly(ADP-ribose) polymerase 1	Homo sapiens	228-232
24646317-0	2014	p53 functional inhibitors behaving like pifithrin-beta counteract the Alzheimer peptide non-beta-amyloid component effects in human SH-SY5Y cells.	pifithrin	40-49	tumor protein p53	Homo sapiens	0-3
24743574-12	2014	Moreover, Bcl-2 expression was completely reversed by treatment with pifithrin-alpha, a p53-specific inhibitor.	pifithrin	69-84	BCL2 apoptosis regulator	Homo sapiens	10-15
24343341-6	2014	The p53/Cyp-D mitochondrial complexation was prevented by CsA or Cyp-D silencing, or by p53 inhibitor pifithrin-alpha.	pifithrin	102-111	tumor protein p53	Homo sapiens	4-7
24343341-6	2014	The p53/Cyp-D mitochondrial complexation was prevented by CsA or Cyp-D silencing, or by p53 inhibitor pifithrin-alpha.	pifithrin	102-111	peptidylprolyl isomerase F	Homo sapiens	8-13
24343341-6	2014	The p53/Cyp-D mitochondrial complexation was prevented by CsA or Cyp-D silencing, or by p53 inhibitor pifithrin-alpha.	pifithrin	102-111	tumor protein p53	Homo sapiens	88-91
24681574-12	2014	IFN-gamma induction of senescence was attenuated by siRNAs against p21, Janus kinase 2 (JAK2) or signal transducer and activator of transcription 1 (STAT1), but not by JAK1 siRNA nor by p53 inhibitor pifithrin-alpha.	pifithrin	200-215	interferon gamma	Homo sapiens	0-9
24667845-5	2014	Using pifithrin-alpha(PFT), a p53"s mitochondrial translocation inhibitor, we found that pretreated with PFT, heat stress induced mitochondrial p53 translocation was significantly suppressed, accompanied by a significant alleviation in the loss of DeltaPsim, cytochrome c release and caspase-9 activation.	pifithrin	6-21	tumor protein p53	Homo sapiens	144-147
24667845-5	2014	Using pifithrin-alpha(PFT), a p53"s mitochondrial translocation inhibitor, we found that pretreated with PFT, heat stress induced mitochondrial p53 translocation was significantly suppressed, accompanied by a significant alleviation in the loss of DeltaPsim, cytochrome c release and caspase-9 activation.	pifithrin	6-21	cytochrome c, somatic	Homo sapiens	259-271
24667845-5	2014	Using pifithrin-alpha(PFT), a p53"s mitochondrial translocation inhibitor, we found that pretreated with PFT, heat stress induced mitochondrial p53 translocation was significantly suppressed, accompanied by a significant alleviation in the loss of DeltaPsim, cytochrome c release and caspase-9 activation.	pifithrin	6-21	caspase 9	Homo sapiens	284-293
24070868-7	2014	Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function.	pifithrin	128-143	caspase 6	Mus musculus	89-98
24280010-8	2014	Finally, both the functional inhibition of Hsp70 ATPase activity by methylene blue (MB), and the antagonism of Hsp70 substrate binding site (SBD) activity by pifithrin-mu (PES) impaired the development of behavioural sensitization when they were microinjected into the NAc core.	pifithrin	158-167	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	111-116
24516131-10	2014	Furthermore, pifithrin-alpha, a specific inhibitor of p53, ameliorates mitochondrial dysfunction and glucose intolerance in both STZ-treated and db/db mice.	pifithrin	13-28	transformation related protein 53, pseudogene	Mus musculus	54-57
24070868-7	2014	Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function.	pifithrin	128-143	transformation related protein 53, pseudogene	Mus musculus	172-175
24070868-7	2014	Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function.	pifithrin	128-143	transformation related protein 53, pseudogene	Mus musculus	236-239
24070868-7	2014	Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function.	pifithrin	145-153	caspase 6	Mus musculus	89-98
24070868-7	2014	Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function.	pifithrin	145-153	transformation related protein 53, pseudogene	Mus musculus	172-175
24070868-7	2014	Using mouse embryonic fibroblasts (MEFs) from YAC128 mice, we show that this increase in caspase-6 activity can be mitigated by pifithrin-alpha (pifalpha), an inhibitor of p53 transcriptional activity, but not through the inhibition of p53"s mitochondrial pro-apoptotic function.	pifithrin	145-153	transformation related protein 53, pseudogene	Mus musculus	236-239
23872073-5	2013	Genetic deficiency of either EGFR or p53 or functional blockade with AG1478 or Pifithrin-alpha, respectively, effectively inhibited PAI-1and CTGF induction and morphological transformation of renal fibroblasts as did SMAD3 knockdown or pretreatment with the SMAD3 inhibitor SIS3.	pifithrin	79-94	serpin family E member 1	Homo sapiens	132-137
24120424-8	2014	OA-induced changes in cell viability and ATP production were rescued to control levels when cells were pretreated with pifithrin-alpha (PTA), a p53 inhibitor.	pifithrin	119-134	tumor protein p53	Homo sapiens	144-147
26629941-6	2014	Notably, these expression changes could be neutralized by PFTalpha, an inhibitor of p53 signaling pathway that could inhibit p53-dependent transactivation of p53-responsive genes.	pifithrin	58-66	tumor protein p53	Homo sapiens	84-87
26629941-6	2014	Notably, these expression changes could be neutralized by PFTalpha, an inhibitor of p53 signaling pathway that could inhibit p53-dependent transactivation of p53-responsive genes.	pifithrin	58-66	tumor protein p53	Homo sapiens	125-128
26629941-6	2014	Notably, these expression changes could be neutralized by PFTalpha, an inhibitor of p53 signaling pathway that could inhibit p53-dependent transactivation of p53-responsive genes.	pifithrin	58-66	tumor protein p53	Homo sapiens	125-128
25379568-10	2014	Inhibiting p53 function with pifithrin alpha prevented the promotion of HRS by VorinostatSAHA.	pifithrin	29-44	tumor protein p53	Homo sapiens	11-14
23872073-5	2013	Genetic deficiency of either EGFR or p53 or functional blockade with AG1478 or Pifithrin-alpha, respectively, effectively inhibited PAI-1and CTGF induction and morphological transformation of renal fibroblasts as did SMAD3 knockdown or pretreatment with the SMAD3 inhibitor SIS3.	pifithrin	79-94	cellular communication network factor 2	Homo sapiens	141-145
22976055-5	2013	The p53 inhibitor pifithrin-alpha (PFT-alpha) knockdown of the signaling of p53 led vitexin to lose its antitumor effect and inhibited the expression of p53 downstream genes, p2(WAF1) and Bax.	pifithrin	18-27	tumor protein p53	Homo sapiens	4-7
21887816-6	2013	Pretreatment with cytochrome P450 inhibitor alpha-naphthoflavone or p53 inhibitor pifithrin-alpha inhibited the benzo-[a]-pyrene-induced p21 expression.	pifithrin	82-91	tumor protein p53	Homo sapiens	68-71
21887816-6	2013	Pretreatment with cytochrome P450 inhibitor alpha-naphthoflavone or p53 inhibitor pifithrin-alpha inhibited the benzo-[a]-pyrene-induced p21 expression.	pifithrin	82-91	cyclin dependent kinase inhibitor 1A	Homo sapiens	137-140
24179522-5	2013	The interaction between p53 and VEGF in the EGCG-treated cells was investigated using pifithrin-alpha.	pifithrin	86-95	tumor protein p53	Homo sapiens	24-27
24179522-5	2013	The interaction between p53 and VEGF in the EGCG-treated cells was investigated using pifithrin-alpha.	pifithrin	86-95	vascular endothelial growth factor A	Homo sapiens	32-36
24059678-4	2013	In addition, while radiation-induced expression and phosphorylation of p53, inhibition of p53 function with pifithrin-alpha or transfection of cells with p53 siRNA significantly reduced the activation of both MMP2 and VEGF and resulted in a reduction of radiation-induced invasiveness.	pifithrin	108-123	tumor protein p53	Homo sapiens	90-93
24059678-4	2013	In addition, while radiation-induced expression and phosphorylation of p53, inhibition of p53 function with pifithrin-alpha or transfection of cells with p53 siRNA significantly reduced the activation of both MMP2 and VEGF and resulted in a reduction of radiation-induced invasiveness.	pifithrin	108-123	tumor protein p53	Homo sapiens	90-93
24059678-4	2013	In addition, while radiation-induced expression and phosphorylation of p53, inhibition of p53 function with pifithrin-alpha or transfection of cells with p53 siRNA significantly reduced the activation of both MMP2 and VEGF and resulted in a reduction of radiation-induced invasiveness.	pifithrin	108-123	matrix metallopeptidase 2	Homo sapiens	209-213
23644056-5	2013	The I/R-induced increases of protein levels of p53 and LC3-II were significantly inhibited by treatment with propofol, 3-MA or PFT-alpha.	pifithrin	127-136	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
23652278-12	2013	An inhibitor of p53, pifithrin-alpha, attenuated the anticancer effects of OSU-03012 and downregulated the expression of Bax and cleaved caspase-9.	pifithrin	21-30	tumor protein p53	Homo sapiens	16-19
23652278-12	2013	An inhibitor of p53, pifithrin-alpha, attenuated the anticancer effects of OSU-03012 and downregulated the expression of Bax and cleaved caspase-9.	pifithrin	21-30	BCL2 associated X, apoptosis regulator	Homo sapiens	121-124
23652278-12	2013	An inhibitor of p53, pifithrin-alpha, attenuated the anticancer effects of OSU-03012 and downregulated the expression of Bax and cleaved caspase-9.	pifithrin	21-30	caspase 9	Homo sapiens	137-146
23648290-8	2013	A reduction by approximately 50% in the cytotoxicity of Gem and Clo was observed in the presence of pifithrin alpha, a p53 inhibitor.	pifithrin	100-115	tumor protein p53	Homo sapiens	119-122
22976055-5	2013	The p53 inhibitor pifithrin-alpha (PFT-alpha) knockdown of the signaling of p53 led vitexin to lose its antitumor effect and inhibited the expression of p53 downstream genes, p2(WAF1) and Bax.	pifithrin	18-27	tumor protein p53	Homo sapiens	76-79
22976055-5	2013	The p53 inhibitor pifithrin-alpha (PFT-alpha) knockdown of the signaling of p53 led vitexin to lose its antitumor effect and inhibited the expression of p53 downstream genes, p2(WAF1) and Bax.	pifithrin	18-27	tumor protein p53	Homo sapiens	76-79
22976055-5	2013	The p53 inhibitor pifithrin-alpha (PFT-alpha) knockdown of the signaling of p53 led vitexin to lose its antitumor effect and inhibited the expression of p53 downstream genes, p2(WAF1) and Bax.	pifithrin	18-27	cyclin dependent kinase inhibitor 1A	Homo sapiens	178-182
22976055-5	2013	The p53 inhibitor pifithrin-alpha (PFT-alpha) knockdown of the signaling of p53 led vitexin to lose its antitumor effect and inhibited the expression of p53 downstream genes, p2(WAF1) and Bax.	pifithrin	18-27	BCL2 associated X, apoptosis regulator	Homo sapiens	188-191
22647551-7	2013	Finally, the selective Hsp70 inhibitor pifithrin-mu (PES) i.c.v.	pifithrin	39-48	heat shock protein 1B	Mus musculus	23-28
25470941-0	2013	Effect of p53 inhibition by pifithrin-alpha on functional activity of vasopressin neurones in rat hypothalamus.	pifithrin	28-43	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	10-13
25470941-0	2013	Effect of p53 inhibition by pifithrin-alpha on functional activity of vasopressin neurones in rat hypothalamus.	pifithrin	28-43	arginine vasopressin	Rattus norvegicus	70-81
23640975-6	2013	In human HNSCC expressing PIK3CA and decreased wtTP53 and p73, PF-502 reciprocally enhanced TP53/p73 expression and growth inhibition, which was partially reversible by p53 inhibitor pifithrin-alpha.	pifithrin	183-192	tumor protein p53	Homo sapiens	169-172
22983795-9	2013	Pretreatment with pifithrin-alpha, a p53 inhibitor, significantly diminished p53 phosphorylation at the concentration of 30 muM and abrogated quercetin-induced apoptosis in a dose-dependent manner.	pifithrin	18-33	tumor protein p53	Homo sapiens	37-40
22983795-9	2013	Pretreatment with pifithrin-alpha, a p53 inhibitor, significantly diminished p53 phosphorylation at the concentration of 30 muM and abrogated quercetin-induced apoptosis in a dose-dependent manner.	pifithrin	18-33	tumor protein p53	Homo sapiens	77-80
23908686-6	2013	Furthermore, SNX2112 enhanced re-expression of TP53 and targets p21WAF1 and PUMA, while TP53 inhibitor Pifithrin or siRNA attenuated the antiproliferative activity of SNX2112 in wtTP53 HNSCC in vitro.	pifithrin	103-112	transformation related protein 53	Mus musculus	88-92
23500643-5	2013	Inhibition of p53 either as a transcription factor by pifithrin alpha or in its mitochondrial role by pifithrin mu significantly reduced ESC death levels.	pifithrin	54-63	transformation related protein 53, pseudogene	Mus musculus	14-17
23500643-5	2013	Inhibition of p53 either as a transcription factor by pifithrin alpha or in its mitochondrial role by pifithrin mu significantly reduced ESC death levels.	pifithrin	102-111	transformation related protein 53, pseudogene	Mus musculus	14-17
23371857-0	2013	The HSP70 and autophagy inhibitor pifithrin-mu enhances the antitumor effects of TRAIL on human pancreatic cancer.	pifithrin	34-43	TNF superfamily member 10	Homo sapiens	81-86
23454130-0	2013	Pifithrin-alpha, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	48-51
23454130-0	2013	Pifithrin-alpha, a pharmacological inhibitor of p53, downregulates lipopolysaccharide-induced nitric oxide production via impairment of the MyD88-independent pathway.	pifithrin	0-15	myeloid differentiation primary response gene 88	Mus musculus	140-145
23371857-2	2013	To improve TRAIL-induced antitumor effects, we tested its effectiveness in combination with pifithrin (PFT)-mu, which has the potential to inhibit HSP70 function and autophagy, both of which participate in TRAIL resistance in cancer cells.	pifithrin	92-101	heat shock protein family A (Hsp70) member 4	Homo sapiens	147-152
23371857-2	2013	To improve TRAIL-induced antitumor effects, we tested its effectiveness in combination with pifithrin (PFT)-mu, which has the potential to inhibit HSP70 function and autophagy, both of which participate in TRAIL resistance in cancer cells.	pifithrin	92-101	TNF superfamily member 10	Homo sapiens	206-211
23859040-5	2013	The presence of pifithrin, an inhibitor of p53 function, blocked ECG-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among Bcl-2 anti- and proapoptotic protein levels.	pifithrin	16-25	tumor protein p53	Homo sapiens	43-46
22860893-5	2013	IL-24-mediated apoptosis was also antagonized by pifithrin-alpha, an inhibitor of p53 transactivation.	pifithrin	49-64	interleukin 24	Homo sapiens	0-5
22860893-5	2013	IL-24-mediated apoptosis was also antagonized by pifithrin-alpha, an inhibitor of p53 transactivation.	pifithrin	49-64	tumor protein p53	Homo sapiens	82-85
23201429-8	2013	Inhibitors of NADPH oxidase (diphenylene iodonium chloride), NF-kappaB (isohelenin) and p53 (pifithrin-alpha,p-nitro) suppressed indoxyl sulfate-induced expression of ICAM-1 mRNA and protein in HK-2 cells.	pifithrin	93-108	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	88-91
23363842-5	2013	RESULTS: Both indoxyl sulfate and nutlin-3, a specific p53 inducer, stimulated TGF-beta1 expression, which was suppressed by pifithrin-alpha, p-nitro, a p53 inhibitor.	pifithrin	125-140	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	55-58
23363842-5	2013	RESULTS: Both indoxyl sulfate and nutlin-3, a specific p53 inducer, stimulated TGF-beta1 expression, which was suppressed by pifithrin-alpha, p-nitro, a p53 inhibitor.	pifithrin	125-140	transforming growth factor, beta 1	Rattus norvegicus	79-88
23363842-5	2013	RESULTS: Both indoxyl sulfate and nutlin-3, a specific p53 inducer, stimulated TGF-beta1 expression, which was suppressed by pifithrin-alpha, p-nitro, a p53 inhibitor.	pifithrin	125-140	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	153-156
23816816-9	2013	These effects were absent when the caspase inhibitor z-VAD-fmk or p53 inhibitor PFTalpha were applied, suggesting that casticin could trigger cell apoptosis in a caspase-3 and p53-dependent manner.	pifithrin	80-88	tumor protein p53	Homo sapiens	66-69
23535401-8	2013	Furthermore, pretreatment with either p53 inhibitor pifithrin-alpha or calcium chelator BAPTA-AM effectively attenuated apoptosis induced by crotonaldehyde.	pifithrin	52-67	tumor protein p53	Homo sapiens	38-41
23201752-5	2013	Cell exposure to pifithrin, an inhibitor of p53 transcriptional activity, reduced the caspase activity associated with decreased miR-21 expression.	pifithrin	17-26	tumor protein p53	Homo sapiens	44-47
23201752-5	2013	Cell exposure to pifithrin, an inhibitor of p53 transcriptional activity, reduced the caspase activity associated with decreased miR-21 expression.	pifithrin	17-26	microRNA 21	Homo sapiens	129-135
23222126-5	2013	Acute inhibition of p53 with pifithrin-alpha in wild-type mice mimicked the observations in p53(-/-) mice.	pifithrin	29-38	transformation related protein 53, pseudogene	Mus musculus	20-23
23222126-5	2013	Acute inhibition of p53 with pifithrin-alpha in wild-type mice mimicked the observations in p53(-/-) mice.	pifithrin	29-38	transformation related protein 53, pseudogene	Mus musculus	92-95
23222126-9	2013	Finally, models of peritonitis in p53(-/-) and pifithrin-alpha-treated mice confirmed the anti-inflammatory role of p53 and its effect on the polarization of macrophage phenotype.	pifithrin	47-56	transformation related protein 53, pseudogene	Mus musculus	116-119
23859040-5	2013	The presence of pifithrin, an inhibitor of p53 function, blocked ECG-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among Bcl-2 anti- and proapoptotic protein levels.	pifithrin	16-25	caspase 3	Homo sapiens	136-145
23859040-5	2013	The presence of pifithrin, an inhibitor of p53 function, blocked ECG-induced apoptosis as was manifested by restored cell viability and caspase-3 activity to control values and reestablished the balance among Bcl-2 anti- and proapoptotic protein levels.	pifithrin	16-25	BCL2 apoptosis regulator	Homo sapiens	209-214
22886373-8	2012	ROS-mediated p53 activation was found to involve in Cr(VI)-induced cell cycle arrest, and p53 inhibitor Pifithrin-alpha (PFT-alpha) rescued Cr(VI)-induced reduction of check point proteins Mrc1 and BubR1, thus inhibiting cell cycle arrest.	pifithrin	104-113	tumor protein p53	Homo sapiens	90-93
23349842-6	2013	A p53 inhibitor pifithrin-alpha inhibited the expression of p21(Cip1) and attenuated homocysteine-induced cell growth arrest.	pifithrin	16-31	tumor protein p53	Homo sapiens	2-5
23349842-6	2013	A p53 inhibitor pifithrin-alpha inhibited the expression of p21(Cip1) and attenuated homocysteine-induced cell growth arrest.	pifithrin	16-31	H3 histone pseudogene 16	Homo sapiens	60-63
23349842-6	2013	A p53 inhibitor pifithrin-alpha inhibited the expression of p21(Cip1) and attenuated homocysteine-induced cell growth arrest.	pifithrin	16-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	64-68
25049533-1	2012	The aim of this study was to investigate the impact of a reported p53 inhibitor, pifithrin-alpha (PFT-alpha), on preimplantation porcine in vitro fertilized (IVF) embryo development in culture.	pifithrin	81-90	tumor protein p53	Homo sapiens	66-69
22886373-8	2012	ROS-mediated p53 activation was found to involve in Cr(VI)-induced cell cycle arrest, and p53 inhibitor Pifithrin-alpha (PFT-alpha) rescued Cr(VI)-induced reduction of check point proteins Mrc1 and BubR1, thus inhibiting cell cycle arrest.	pifithrin	104-113	mannose receptor C-type 1	Homo sapiens	189-193
22886373-8	2012	ROS-mediated p53 activation was found to involve in Cr(VI)-induced cell cycle arrest, and p53 inhibitor Pifithrin-alpha (PFT-alpha) rescued Cr(VI)-induced reduction of check point proteins Mrc1 and BubR1, thus inhibiting cell cycle arrest.	pifithrin	104-113	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	198-203
23006892-4	2012	Conversely, PFTalpha caused muscle loss, increased oxidative damage and decreased MnSOD activity in intermyofibrillar (IMF) mitochondria.	pifithrin	12-20	superoxide dismutase 2, mitochondrial	Mus musculus	82-87
23022514-5	2012	The p53 inhibitor pifithrin-mu and pan caspase inhibitor Z-VAD-FMK suppressed rRNA cleavage induced by anisomycin, SG and ricin, indicating that these ribotoxins shared with DON a conserved downstream pathway.	pifithrin	18-27	transformation related protein 53, pseudogene	Mus musculus	4-7
23123091-7	2012	Similar effects were seen with the p53 inhibitor, pifithrin-alpha.	pifithrin	50-65	transformation related protein 53, pseudogene	Mus musculus	35-38
22445757-0	2012	The p53 inhibitor, pifithrin-alpha, suppresses self-renewal of embryonic stem cells.	pifithrin	19-34	tumor protein p53	Homo sapiens	4-7
22420535-7	2012	Further, inhibiting p53 expression by coexpression of SV40 large T antigen and buffalo defined factors in BFFs or treating BFFs with p53 inhibitor pifithrin-a (PFT) could increase the efficiency of biPSCs generation up to 3-fold, and nuclear transfer embryos reconstructed with biPSCs could develop to blastocysts.	pifithrin	147-158	cellular tumor antigen p53	Bubalus bubalis	20-23
22420535-7	2012	Further, inhibiting p53 expression by coexpression of SV40 large T antigen and buffalo defined factors in BFFs or treating BFFs with p53 inhibitor pifithrin-a (PFT) could increase the efficiency of biPSCs generation up to 3-fold, and nuclear transfer embryos reconstructed with biPSCs could develop to blastocysts.	pifithrin	147-158	cellular tumor antigen p53	Bubalus bubalis	133-136
22519734-10	2012	Furthermore, blocking p53-mediated transcription using pifithrin significantly reduced apoptosis.	pifithrin	55-64	tumor protein p53	Homo sapiens	22-25
22491426-5	2012	Furthermore, rRNA fragmentation was suppressed by the p53 inhibitors pifithrin-alpha and pifithrin-mu as well as the pan caspase inhibitor Z-VAD-FMK.	pifithrin	69-78	tumor protein p53	Homo sapiens	54-57
22491426-5	2012	Furthermore, rRNA fragmentation was suppressed by the p53 inhibitors pifithrin-alpha and pifithrin-mu as well as the pan caspase inhibitor Z-VAD-FMK.	pifithrin	89-98	tumor protein p53	Homo sapiens	54-57
22445757-3	2012	In this study, we investigated the effect of pifithrin (PFT)-alpha, an inhibitor of p53-dependent transcriptional activation, on self-renewal of ES cells.	pifithrin	45-54	tumor protein p53	Homo sapiens	84-87
22154326-7	2012	N-acetyl L cysteins and pifithrin-alpha, an inhibitor of p53 abrogated glucolipotoxicity-induced ROS generation and p53 expression.	pifithrin	24-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	57-60
22154326-7	2012	N-acetyl L cysteins and pifithrin-alpha, an inhibitor of p53 abrogated glucolipotoxicity-induced ROS generation and p53 expression.	pifithrin	24-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	116-119
21889606-0	2011	Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-alpha, an inhibitor of p53.	pifithrin	99-114	tumor protein p53	Homo sapiens	132-135
22387547-3	2012	METHODS: Human hepatoma cells (HepG2.2.15) were transfected with XPD expression vector, followed by incubation with Pifithrin-alpha (P53 inhibitor).	pifithrin	116-131	tumor protein p53	Homo sapiens	133-136
22387547-8	2012	However, the inhibition of P53 by Pifithrin-alpha abolished the above-mentioned effects of XPD.	pifithrin	34-43	tumor protein p53	Homo sapiens	27-30
22387547-8	2012	However, the inhibition of P53 by Pifithrin-alpha abolished the above-mentioned effects of XPD.	pifithrin	34-43	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	91-94
22049400-0	2012	The p53 inhibitor pifithrin-alpha can stimulate fibrosis in a rat model of ischemic acute kidney injury.	pifithrin	18-33	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
23300887-13	2012	Inhibitor of p53, pifithrin-alpha, attenuated the anti-cancer effects of SDGE and apoptosis was also not observed in the p53(neg) SKOV-3 cells.	pifithrin	18-33	tumor protein p53	Homo sapiens	13-16
22815878-6	2012	In contrast, administration of pifithrin-alpha (a p53 activity inhibitor) during hypoxia resulted in protein levels that were similar to those of the control groups.	pifithrin	31-46	tumor protein p53	Homo sapiens	50-53
21780161-9	2011	Pifithrin-alpha, a p53 inhibitor, decreased the p-p53, p21(Cip1) and p27(Kip1) levels, and the percentage in G1 phase in the absence of MgCl(2) .	pifithrin	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	19-22
21780161-9	2011	Pifithrin-alpha, a p53 inhibitor, decreased the p-p53, p21(Cip1) and p27(Kip1) levels, and the percentage in G1 phase in the absence of MgCl(2) .	pifithrin	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	50-53
21780161-9	2011	Pifithrin-alpha, a p53 inhibitor, decreased the p-p53, p21(Cip1) and p27(Kip1) levels, and the percentage in G1 phase in the absence of MgCl(2) .	pifithrin	0-15	KRAS proto-oncogene, GTPase	Rattus norvegicus	55-58
21780161-9	2011	Pifithrin-alpha, a p53 inhibitor, decreased the p-p53, p21(Cip1) and p27(Kip1) levels, and the percentage in G1 phase in the absence of MgCl(2) .	pifithrin	0-15	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	59-63
21780161-9	2011	Pifithrin-alpha, a p53 inhibitor, decreased the p-p53, p21(Cip1) and p27(Kip1) levels, and the percentage in G1 phase in the absence of MgCl(2) .	pifithrin	0-15	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	69-72
21780161-9	2011	Pifithrin-alpha, a p53 inhibitor, decreased the p-p53, p21(Cip1) and p27(Kip1) levels, and the percentage in G1 phase in the absence of MgCl(2) .	pifithrin	0-15	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	73-77
22436728-7	2012	Injection of mice with pifithrin-alpha, a putative p53 inhibitor, prevented miR-34a upregulation after seizures.	pifithrin	23-38	transformation related protein 53, pseudogene	Mus musculus	51-54
22436728-7	2012	Injection of mice with pifithrin-alpha, a putative p53 inhibitor, prevented miR-34a upregulation after seizures.	pifithrin	23-38	microRNA 34a	Mus musculus	76-83
22283740-5	2012	Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, reduced ROS production and reversed silibinin"s growth-inhibitory effect.	pifithrin	0-15	tumor protein p53	Homo sapiens	53-56
22253887-7	2012	Mild heat treatment also induces expression of HSP70 and use of HSP70 inhibitors (KNK437 or Pifithrin-micro) largely abrogates the ability of the thermal treatment to enhance TNF-alpha, suggesting that the induction of HSP70 is important for mediation of thermal effects on macrophage function.	pifithrin	92-101	heat shock protein 1B	Mus musculus	64-69
22253887-7	2012	Mild heat treatment also induces expression of HSP70 and use of HSP70 inhibitors (KNK437 or Pifithrin-micro) largely abrogates the ability of the thermal treatment to enhance TNF-alpha, suggesting that the induction of HSP70 is important for mediation of thermal effects on macrophage function.	pifithrin	92-101	tumor necrosis factor	Mus musculus	175-184
22253887-7	2012	Mild heat treatment also induces expression of HSP70 and use of HSP70 inhibitors (KNK437 or Pifithrin-micro) largely abrogates the ability of the thermal treatment to enhance TNF-alpha, suggesting that the induction of HSP70 is important for mediation of thermal effects on macrophage function.	pifithrin	92-101	heat shock protein 1B	Mus musculus	64-69
22044530-5	2011	TCDD suppressed 1-NP- but not BaP-induced p53 activity, and in contrast, pifithrin-alpha (PFT-alpha), a p53 inhibitor, suppressed both 1-NP- and BaP-induced p53 activity.	pifithrin	73-82	tumor protein p53	Homo sapiens	104-107
22044530-5	2011	TCDD suppressed 1-NP- but not BaP-induced p53 activity, and in contrast, pifithrin-alpha (PFT-alpha), a p53 inhibitor, suppressed both 1-NP- and BaP-induced p53 activity.	pifithrin	73-82	tumor protein p53	Homo sapiens	104-107
21715570-7	2011	The p53 inhibitor pifithrin-alpha inhibited 3-NBA-induced apoptosis while small effects were seen using pifithrin-mu, suggesting that 3-NBA-induced cell death is a result of transcriptional activation of p53.	pifithrin	18-33	tumor protein p53	Homo sapiens	4-7
21715570-7	2011	The p53 inhibitor pifithrin-alpha inhibited 3-NBA-induced apoptosis while small effects were seen using pifithrin-mu, suggesting that 3-NBA-induced cell death is a result of transcriptional activation of p53.	pifithrin	18-33	tumor protein p53	Homo sapiens	204-207
22260024-8	2011	In addition, the cell growth inhibitory ratio and the apoptotic ratio of resveratrol-treated group decreased markedly by the p38 MAPK inhibitor SB203580 or p53 inhibitor pifithrin-alpha.	pifithrin	170-185	tumor protein p53	Homo sapiens	156-159
21524699-10	2011	In addition, a chemical inhibitor of p53, PFTalpha, significantly decreased AT-II-mediated growth inhibition and apoptosis.	pifithrin	42-50	transformation related protein 53, pseudogene	Mus musculus	37-40
21755988-5	2011	Apo-nNOS activation by this flow-through fraction is inhibited by pifithrin-mu, a small molecule inhibitor of Hsp70, suggesting that a non-ATP-binding form of Hsp70 is involved in heme-dependent apo-nNOS activation.	pifithrin	66-75	nitric oxide synthase 1	Homo sapiens	4-8
21755988-5	2011	Apo-nNOS activation by this flow-through fraction is inhibited by pifithrin-mu, a small molecule inhibitor of Hsp70, suggesting that a non-ATP-binding form of Hsp70 is involved in heme-dependent apo-nNOS activation.	pifithrin	66-75	heat shock protein family A (Hsp70) member 4	Homo sapiens	110-115
21755988-5	2011	Apo-nNOS activation by this flow-through fraction is inhibited by pifithrin-mu, a small molecule inhibitor of Hsp70, suggesting that a non-ATP-binding form of Hsp70 is involved in heme-dependent apo-nNOS activation.	pifithrin	66-75	heat shock protein family A (Hsp70) member 4	Homo sapiens	159-164
21755988-5	2011	Apo-nNOS activation by this flow-through fraction is inhibited by pifithrin-mu, a small molecule inhibitor of Hsp70, suggesting that a non-ATP-binding form of Hsp70 is involved in heme-dependent apo-nNOS activation.	pifithrin	66-75	nitric oxide synthase 1	Homo sapiens	199-203
21593185-9	2011	Inhibition of p53 by pifithrin-alpha reversed the effect of EX527 in protein expression of PUMA-alpha, Bcl-xL, and caspase-3 and cytotoxicity in MPT cells.	pifithrin	21-30	transformation related protein 53, pseudogene	Mus musculus	14-17
21859809-4	2011	Moreover, MCP-1 upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs.	pifithrin	84-99	tumor protein p53	Homo sapiens	61-64
21859809-4	2011	Moreover, MCP-1 upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs.	pifithrin	84-99	C-C motif chemokine ligand 2	Homo sapiens	123-128
21859809-4	2011	Moreover, MCP-1 upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs.	pifithrin	101-109	tumor protein p53	Homo sapiens	61-64
21859809-4	2011	Moreover, MCP-1 upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs.	pifithrin	101-109	C-C motif chemokine ligand 2	Homo sapiens	123-128
22829184-0	2011	Antileukemic activity of the HSP70 inhibitor pifithrin-mu in acute leukemia.	pifithrin	45-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	29-34
22829184-2	2011	Here, we analyzed the in vitro antileukemic effects of pifithrin-mu (PFT-mu), an inhibitor of inducible HSP70, in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cell lines, as well as in primary AML blasts.	pifithrin	55-64	heat shock protein family A (Hsp70) member 4	Homo sapiens	104-109
21163271-12	2011	p53-specific transcriptional inhibitor pifithrin-alpha or mitochondrial translocation inhibitor pifithrin-mu partially reversed solamargine-induced apoptosis.	pifithrin	39-48	tumor protein p53	Homo sapiens	0-3
21362431-0	2011	Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-alpha and its condensation product pifithrin-beta.	pifithrin	92-107	cellular tumor antigen p53	Oncorhynchus mykiss	78-81
21362431-1	2011	AIMS: Pifithrin alpha (PFTalpha), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy.	pifithrin	6-21	cellular tumor antigen p53	Oncorhynchus mykiss	54-57
21362431-1	2011	AIMS: Pifithrin alpha (PFTalpha), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy.	pifithrin	23-31	cellular tumor antigen p53	Oncorhynchus mykiss	54-57
21362431-10	2011	SIGNIFICANCE: Since PFTalpha is a promising compound for the development of new pharmaceuticals inhibiting p53, the chemical instability of this compound as well as the capacity of its transformation product should be taken into account.	pifithrin	20-28	cellular tumor antigen p53	Oncorhynchus mykiss	107-110
21324703-2	2011	In an attempt to identify novel p53 inhibitors, a quality collection of compounds structurally related to pifithrin-beta were designed and synthesized as potential inhibitors of p53.	pifithrin	106-115	tumor protein p53	Homo sapiens	32-35
21324703-2	2011	In an attempt to identify novel p53 inhibitors, a quality collection of compounds structurally related to pifithrin-beta were designed and synthesized as potential inhibitors of p53.	pifithrin	106-115	tumor protein p53	Homo sapiens	178-181
21074539-2	2011	We hypothesized that pifithrin-alpha (PFTa), a synthetic p53 inhibitor, would suppress cardiac apoptosis through the disruption of p53-dependent transcriptional activation and thereby improve heart function in a mouse model of MI.	pifithrin	21-36	transformation related protein 53, pseudogene	Mus musculus	57-60
21074539-2	2011	We hypothesized that pifithrin-alpha (PFTa), a synthetic p53 inhibitor, would suppress cardiac apoptosis through the disruption of p53-dependent transcriptional activation and thereby improve heart function in a mouse model of MI.	pifithrin	21-36	transformation related protein 53, pseudogene	Mus musculus	131-134
21074539-2	2011	We hypothesized that pifithrin-alpha (PFTa), a synthetic p53 inhibitor, would suppress cardiac apoptosis through the disruption of p53-dependent transcriptional activation and thereby improve heart function in a mouse model of MI.	pifithrin	38-42	transformation related protein 53, pseudogene	Mus musculus	57-60
21074539-2	2011	We hypothesized that pifithrin-alpha (PFTa), a synthetic p53 inhibitor, would suppress cardiac apoptosis through the disruption of p53-dependent transcriptional activation and thereby improve heart function in a mouse model of MI.	pifithrin	38-42	transformation related protein 53, pseudogene	Mus musculus	131-134
21074539-3	2011	In our experiments we show that PFTa blocked p53 transcriptional activity and attenuated H(2)O(2)-induced cardiac apoptosis in cultured neonatal rat cardiomyocytes.	pifithrin	32-36	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	45-48
21074539-5	2011	Subsequent analysis revealed significantly reduced proliferation and cell number, diminished collagen deposition, and elevated MMP-2 activity at the infarct zone of PFTa-treated hearts.	pifithrin	165-169	matrix metallopeptidase 2	Mus musculus	127-132
21074539-7	2011	Collectively, our data suggest that although p53-inhibition through PFTa reduces cardiomyocyte apoptosis, in the setting of acute MI this assumed beneficial effect is severely counteracted by the adverse remodeling of the infarct zone.	pifithrin	68-72	transformation related protein 53, pseudogene	Mus musculus	45-48
21074539-8	2011	PFTa increases MMP-2 activity in a p53-dependent manner, which seems a major contributor to instability of the forming scar and consequently leads to infarct progression and ventricular rupture.	pifithrin	0-4	matrix metallopeptidase 2	Mus musculus	15-20
21074539-8	2011	PFTa increases MMP-2 activity in a p53-dependent manner, which seems a major contributor to instability of the forming scar and consequently leads to infarct progression and ventricular rupture.	pifithrin	0-4	transformation related protein 53, pseudogene	Mus musculus	35-38
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	pifithrin	125-140	Fas ligand	Homo sapiens	0-4
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	pifithrin	125-140	caspase 8	Homo sapiens	34-60
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	pifithrin	125-140	tumor protein p53	Homo sapiens	111-114
21130866-8	2011	FasL up-regulation; activation of caspases-8, -2, -9, and -3; and chromatin condensation were decreased by the p53 inhibitor pifithrin-alpha, implicating p53 as an upstream factor in the activation of death receptor-mediated apoptosis by H(2)O(2).	pifithrin	125-140	tumor protein p53	Homo sapiens	154-157
21372157-3	2011	Moreover, the selective effect on erythropoiesis can be mimicked by activating p53 with the compound nutlin-3 and prevented by pifithrin-, an inhibitor of p53 activation.	pifithrin	127-136	tumor protein p53	Homo sapiens	155-158
21266543-11	2011	The Pifithrin-alpha, an specific inhibitor of p53, inhibited the apoptosis and prevented the disruption of cytoskeleton induced by abnormal gravity.	pifithrin	4-14	tumor protein p53	Homo sapiens	46-49
21092747-9	2011	Intraperitoneal administration of p53 inhibitor pifithrin-alpha significantly ameliorated neuronal death in the pontine nuclei of SCA3 transgenic mice.	pifithrin	48-57	transformation related protein 53, pseudogene	Mus musculus	34-37
21092747-9	2011	Intraperitoneal administration of p53 inhibitor pifithrin-alpha significantly ameliorated neuronal death in the pontine nuclei of SCA3 transgenic mice.	pifithrin	48-57	ataxin 3	Mus musculus	130-134
21274377-8	2011	We detected the effects of p53-mediated autophagy activation on the apoptosis of SGC7901 cells with the p53 inhibitor pifithrin-alpha.	pifithrin	118-133	tumor protein p53	Homo sapiens	27-30
21274377-8	2011	We detected the effects of p53-mediated autophagy activation on the apoptosis of SGC7901 cells with the p53 inhibitor pifithrin-alpha.	pifithrin	118-133	tumor protein p53	Homo sapiens	104-107
21274377-13	2011	SN50-induced increases in PUMA, DRAM, LC3 and Beclin 1 and cell death were blocked by the p53 specific inhibitor pifithrin-alpha.	pifithrin	113-128	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	38-41
21274377-13	2011	SN50-induced increases in PUMA, DRAM, LC3 and Beclin 1 and cell death were blocked by the p53 specific inhibitor pifithrin-alpha.	pifithrin	113-128	tumor protein p53	Homo sapiens	90-93
20386864-8	2010	Inhibition of p53 with pifithrin-alpha abrogated the induction of miR-34a during cisplatin treatment of proximal tubular cells.	pifithrin	23-32	transformation related protein 53, pseudogene	Mus musculus	14-17
21294958-0	2011	Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-alpha.	pifithrin	103-112	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	87-90
22041910-0	2011	High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-alpha.	pifithrin	132-141	insulin like growth factor binding protein 3	Homo sapiens	32-39
22041910-0	2011	High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-alpha.	pifithrin	132-141	tumor protein p53	Homo sapiens	109-112
22041910-7	2011	The induction of IGFBP-3 by PN was inhibited by a p53-specific inhibitor, pifithrin-alpha, in a dose-dependent manner, but was not affected by PD169316 (MAPK inhibitor), AS601245 (c-Jun N-terminal kinase inhibitor) or SL327 (MEK1/2 inhibitor).	pifithrin	74-89	insulin like growth factor binding protein 3	Homo sapiens	17-24
22041910-7	2011	The induction of IGFBP-3 by PN was inhibited by a p53-specific inhibitor, pifithrin-alpha, in a dose-dependent manner, but was not affected by PD169316 (MAPK inhibitor), AS601245 (c-Jun N-terminal kinase inhibitor) or SL327 (MEK1/2 inhibitor).	pifithrin	74-89	tumor protein p53	Homo sapiens	50-53
20708607-11	2010	Inhibition of p53 expression by a specific p53 inhibitor pifithrin-alpha reduced the phosphorylated p38 MAP kinase and active caspase-3 proteins in the oxaliplatin-exposed RKO cells.	pifithrin	57-66	tumor protein p53	Homo sapiens	14-17
20708607-11	2010	Inhibition of p53 expression by a specific p53 inhibitor pifithrin-alpha reduced the phosphorylated p38 MAP kinase and active caspase-3 proteins in the oxaliplatin-exposed RKO cells.	pifithrin	57-66	tumor protein p53	Homo sapiens	43-46
20708607-11	2010	Inhibition of p53 expression by a specific p53 inhibitor pifithrin-alpha reduced the phosphorylated p38 MAP kinase and active caspase-3 proteins in the oxaliplatin-exposed RKO cells.	pifithrin	57-66	mitogen-activated protein kinase 14	Homo sapiens	100-114
20708607-11	2010	Inhibition of p53 expression by a specific p53 inhibitor pifithrin-alpha reduced the phosphorylated p38 MAP kinase and active caspase-3 proteins in the oxaliplatin-exposed RKO cells.	pifithrin	57-66	caspase 3	Homo sapiens	126-135
20947454-5	2010	In accordance with the dependence of ActD-induced apoptosis on a mitochondrial p53 function, in control T-cells specific inhibition of mitochondrial p53 translocation with mu pifithrin reduced apoptosis by 86%, whereas treatment with alpha pifithrin, which blocks p53-mediated transcription, had no effect.	pifithrin	175-184	tumor protein p53	Homo sapiens	149-152
20947454-5	2010	In accordance with the dependence of ActD-induced apoptosis on a mitochondrial p53 function, in control T-cells specific inhibition of mitochondrial p53 translocation with mu pifithrin reduced apoptosis by 86%, whereas treatment with alpha pifithrin, which blocks p53-mediated transcription, had no effect.	pifithrin	175-184	tumor protein p53	Homo sapiens	149-152
20720180-4	2010	Pifithrin-alpha, p-nitro, a p53 inhibitor, blocked these effects.	pifithrin	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	28-31
20519366-7	2010	Pifithrin (PFT) treatment prevented p73 increase and apoptosis induced by etoposide.	pifithrin	0-9	tumor protein p73	Rattus norvegicus	36-39
20519366-7	2010	Pifithrin (PFT) treatment prevented p73 increase and apoptosis induced by etoposide.	pifithrin	11-14	tumor protein p73	Rattus norvegicus	36-39
21178334-3	2011	METHODS: Rats were treated with p53 inhibitor (pifithrin-alpha) in the moment we injected glycerol.	pifithrin	47-56	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	32-35
21212516-2	2011	Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, reduced autophagy and reversed silibinin"s growth-inhibitory effect; besides, PFT-alpha decreased the activation of caspase-3, a crucial executor of apoptosis.	pifithrin	0-15	tumor protein p53	Homo sapiens	53-56
21212516-2	2011	Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, reduced autophagy and reversed silibinin"s growth-inhibitory effect; besides, PFT-alpha decreased the activation of caspase-3, a crucial executor of apoptosis.	pifithrin	0-15	caspase 3	Homo sapiens	174-183
20718603-2	2010	Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, has been suggested as a combinatory agent in the treatment of p53-deficient tumors in which inhibition of p53 would not compromise therapeutic efficacy but would decrease p53-mediated side effects in normal tissue.	pifithrin	0-10	tumor protein p53	Homo sapiens	53-56
20718603-2	2010	Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, has been suggested as a combinatory agent in the treatment of p53-deficient tumors in which inhibition of p53 would not compromise therapeutic efficacy but would decrease p53-mediated side effects in normal tissue.	pifithrin	0-10	tumor protein p53	Homo sapiens	120-123
20718603-2	2010	Pifithrin-alpha (PFT-alpha), a specific inhibitor of p53, has been suggested as a combinatory agent in the treatment of p53-deficient tumors in which inhibition of p53 would not compromise therapeutic efficacy but would decrease p53-mediated side effects in normal tissue.	pifithrin	0-10	tumor protein p53	Homo sapiens	120-123
20386864-8	2010	Inhibition of p53 with pifithrin-alpha abrogated the induction of miR-34a during cisplatin treatment of proximal tubular cells.	pifithrin	23-32	microRNA 34a	Mus musculus	66-73
20393600-10	2010	FasL upregulation and caspase-8 activation were decreased by p53 inhibitor pifithrin-alpha and antioxidant polyethylene glycol catalase.	pifithrin	75-90	Fas ligand	Homo sapiens	0-4
19859789-0	2010	Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.	pifithrin	7-16	transformation related protein 53, pseudogene	Mus musculus	28-31
19859789-0	2010	Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.	pifithrin	7-16	tumor necrosis factor	Mus musculus	55-58
19859789-2	2010	This study investigates the role that p53 plays in TNF-mediated necrosis of dystrophic myofibres by inhibiting p53 using pifithrin-alpha and three pifithrin-beta analogues.	pifithrin	121-130	transformation related protein 53, pseudogene	Mus musculus	38-41
19859789-2	2010	This study investigates the role that p53 plays in TNF-mediated necrosis of dystrophic myofibres by inhibiting p53 using pifithrin-alpha and three pifithrin-beta analogues.	pifithrin	121-130	tumor necrosis factor	Mus musculus	51-54
19859789-2	2010	This study investigates the role that p53 plays in TNF-mediated necrosis of dystrophic myofibres by inhibiting p53 using pifithrin-alpha and three pifithrin-beta analogues.	pifithrin	121-130	transformation related protein 53, pseudogene	Mus musculus	111-114
19859789-2	2010	This study investigates the role that p53 plays in TNF-mediated necrosis of dystrophic myofibres by inhibiting p53 using pifithrin-alpha and three pifithrin-beta analogues.	pifithrin	147-156	transformation related protein 53, pseudogene	Mus musculus	38-41
19859789-2	2010	This study investigates the role that p53 plays in TNF-mediated necrosis of dystrophic myofibres by inhibiting p53 using pifithrin-alpha and three pifithrin-beta analogues.	pifithrin	147-156	tumor necrosis factor	Mus musculus	51-54
20348016-0	2010	Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53.	pifithrin	82-97	tumor protein p53	Homo sapiens	115-118
20307555-5	2010	This RAR could be slightly reduced by pifithrin-alpha, an inhibitor of P53, however it was completely suppressed by BAY11-7082, an inhibitor of nuclear factor-kappaB (NF-kappaB).	pifithrin	38-53	tumor protein p53	Homo sapiens	71-74
20393600-10	2010	FasL upregulation and caspase-8 activation were decreased by p53 inhibitor pifithrin-alpha and antioxidant polyethylene glycol catalase.	pifithrin	75-90	caspase 8	Homo sapiens	22-31
20393600-10	2010	FasL upregulation and caspase-8 activation were decreased by p53 inhibitor pifithrin-alpha and antioxidant polyethylene glycol catalase.	pifithrin	75-90	tumor protein p53	Homo sapiens	61-64
20586718-8	2010	Analogues of pifithrin-alpha (PFT), which was shown in previous studies to inhibit p53, were designed, synthesized and tested to see whether they would work against cultured brain cells and animal models of neurodegenerative disease.	pifithrin	13-28	transformation related protein 53, pseudogene	Mus musculus	83-86
19955567-6	2010	Furthermore, we characterize for the first time the binding behavior of Pifithrin-mu, a specific small molecule inhibitor of the p53-BclxL interaction, and present a structural model of the protein-ligand complex.	pifithrin	72-81	tumor protein p53	Homo sapiens	129-132
19955567-6	2010	Furthermore, we characterize for the first time the binding behavior of Pifithrin-mu, a specific small molecule inhibitor of the p53-BclxL interaction, and present a structural model of the protein-ligand complex.	pifithrin	72-81	BCL2 like 1	Homo sapiens	133-138
19941874-8	2010	The p53 inhibitor pifithrin-alpha inhibited 3-NBA-induced apoptosis, indicating that cell death was a result of the triggering of DNA signalling pathways.	pifithrin	18-33	transformation related protein 53, pseudogene	Mus musculus	4-7
20586718-8	2010	Analogues of pifithrin-alpha (PFT), which was shown in previous studies to inhibit p53, were designed, synthesized and tested to see whether they would work against cultured brain cells and animal models of neurodegenerative disease.	pifithrin	30-33	transformation related protein 53, pseudogene	Mus musculus	83-86
20036849-3	2010	Co-treatment of cells with SP600125 and p53 inhibitor, pifithrin-alpha, partially nullified the suppressive effects of SP610025 on PS1 expression and secreted Abeta40 level.	pifithrin	55-64	tumor protein p53	Homo sapiens	40-43
20036849-3	2010	Co-treatment of cells with SP600125 and p53 inhibitor, pifithrin-alpha, partially nullified the suppressive effects of SP610025 on PS1 expression and secreted Abeta40 level.	pifithrin	55-64	presenilin 1	Homo sapiens	131-134
19646415-4	2009	Inhibition of NF-kappaB or p53 activation by its specific inhibitor PDTC or pifithrin-alpha respectively, significantly reduced both oridonin-induced apoptosis and autophagy accompanied by the decrease in Beclin 1 and LC3 levels.	pifithrin	76-91	nuclear factor kappa B subunit 1	Homo sapiens	14-23
19895660-7	2010	The p53 transcription inhibitor, pifithrin-alpha, (10 microM) significantly reduced the expression of p53 in microglia and significantly modulated the levels of microglial apoptosis induced by activation.	pifithrin	33-48	tumor protein p53	Homo sapiens	4-7
19895660-7	2010	The p53 transcription inhibitor, pifithrin-alpha, (10 microM) significantly reduced the expression of p53 in microglia and significantly modulated the levels of microglial apoptosis induced by activation.	pifithrin	33-48	tumor protein p53	Homo sapiens	102-105
21071999-0	2010	Pifithrin-alpha, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.	pifithrin	0-15	tumor protein p53	Homo sapiens	33-36
21071999-0	2010	Pifithrin-alpha, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.	pifithrin	0-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	67-72
21071999-2	2010	In this study, we investigated the effect of pifithrin (PFT)-alpha, an inhibitor of p53 transactivation, on COX-2 expression in breast and fibrosarcoma cells.	pifithrin	45-54	tumor protein p53	Homo sapiens	84-87
21071999-2	2010	In this study, we investigated the effect of pifithrin (PFT)-alpha, an inhibitor of p53 transactivation, on COX-2 expression in breast and fibrosarcoma cells.	pifithrin	45-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	108-113
19892935-3	2010	We tested this hypothesis both by studying p53-deficient mice and by blocking p53 in TECs with its inhibitor pifithrin-alpha.	pifithrin	109-124	transformation related protein 53, pseudogene	Mus musculus	78-81
19812371-11	2010	In U87MG (p53wt) cells cotreated with TPT and pifithrin-alpha, or transfected with p53-siRNA, caspase-2 and Bid were significantly cleaved and XIAP/survivin was degraded.	pifithrin	46-55	tumor protein p53	Homo sapiens	10-13
19812371-11	2010	In U87MG (p53wt) cells cotreated with TPT and pifithrin-alpha, or transfected with p53-siRNA, caspase-2 and Bid were significantly cleaved and XIAP/survivin was degraded.	pifithrin	46-55	BH3 interacting domain death agonist	Homo sapiens	108-111
19812371-11	2010	In U87MG (p53wt) cells cotreated with TPT and pifithrin-alpha, or transfected with p53-siRNA, caspase-2 and Bid were significantly cleaved and XIAP/survivin was degraded.	pifithrin	46-55	X-linked inhibitor of apoptosis	Homo sapiens	143-147
19646415-4	2009	Inhibition of NF-kappaB or p53 activation by its specific inhibitor PDTC or pifithrin-alpha respectively, significantly reduced both oridonin-induced apoptosis and autophagy accompanied by the decrease in Beclin 1 and LC3 levels.	pifithrin	76-91	tumor protein p53	Homo sapiens	27-30
19646415-4	2009	Inhibition of NF-kappaB or p53 activation by its specific inhibitor PDTC or pifithrin-alpha respectively, significantly reduced both oridonin-induced apoptosis and autophagy accompanied by the decrease in Beclin 1 and LC3 levels.	pifithrin	76-91	beclin 1	Homo sapiens	205-213
19646415-4	2009	Inhibition of NF-kappaB or p53 activation by its specific inhibitor PDTC or pifithrin-alpha respectively, significantly reduced both oridonin-induced apoptosis and autophagy accompanied by the decrease in Beclin 1 and LC3 levels.	pifithrin	76-91	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	218-221
19184017-7	2009	Importantly, pifithrin-alpha, a p53 inhibitor, protected against DOX-induced mitochondrial depolarization, caspase activation and cell death.	pifithrin	13-22	tumor protein p53	Homo sapiens	32-35
19706164-5	2009	Inhibition of p53 was achieved in U87MG cells transfected with E6 oncoprotein (U87MG-E6) and treated with pifithrin-alpha, a reversible inhibitor of p53 (U87MG-PFT).	pifithrin	106-121	tumor protein p53	Homo sapiens	14-17
19706164-5	2009	Inhibition of p53 was achieved in U87MG cells transfected with E6 oncoprotein (U87MG-E6) and treated with pifithrin-alpha, a reversible inhibitor of p53 (U87MG-PFT).	pifithrin	106-121	tumor protein p53	Homo sapiens	149-152
19644890-14	2009	TUNEL-positive cells and expression of p53, p53AIP-1, and cleaved caspase 9 were increased by shear strain, but chondrocyte apoptosis was suppressed after pretreatment with pifithrin-alpha or p53 siRNA.	pifithrin	173-188	caspase 9	Homo sapiens	66-75
19630168-5	2009	Reduced viability was TRP53 dependent, being partially reversed by a TRP53 inhibitor (Pifithrin-alpha).	pifithrin	86-101	transformation related protein 53	Mus musculus	22-27
19541794-8	2009	Cells pretreatment with the p53 inhibitor pifithrin-alpha suggested that ZEN but not T-2 toxin triggered a p53-dependent mitochondrial apoptotic pathway.	pifithrin	42-51	tumor protein p53	Homo sapiens	28-31
19541794-8	2009	Cells pretreatment with the p53 inhibitor pifithrin-alpha suggested that ZEN but not T-2 toxin triggered a p53-dependent mitochondrial apoptotic pathway.	pifithrin	42-51	tumor protein p53	Homo sapiens	107-110
19630168-5	2009	Reduced viability was TRP53 dependent, being partially reversed by a TRP53 inhibitor (Pifithrin-alpha).	pifithrin	86-101	transformation related protein 53	Mus musculus	69-74
19513548-10	2009	The p53 inhibitor, pifithrin-alpha, was able to counteract the effect of Axin in C6 cells.	pifithrin	19-34	tumor protein p53	Homo sapiens	4-7
19513548-10	2009	The p53 inhibitor, pifithrin-alpha, was able to counteract the effect of Axin in C6 cells.	pifithrin	19-34	axin 1	Homo sapiens	73-77
19088112-2	2009	Male germ cell apoptosis was initiated with doses as low as 0.1 Gy and was prevented by pifithrin alpha, a p53 inhibitor.	pifithrin	88-103	tumor protein p53	Homo sapiens	107-110
19347880-4	2009	Treatment with a p53 specific inhibitor, pifithrin alpha, restored this resistant phenotype in the MCF-7 cell line.	pifithrin	41-50	tumor protein p53	Homo sapiens	17-20
19428812-6	2009	Pifithrin-alpha (PFT), an inhibitor of p53, blocked these processes.	pifithrin	0-15	tumor protein p53	Homo sapiens	39-42
19428812-6	2009	Pifithrin-alpha (PFT), an inhibitor of p53, blocked these processes.	pifithrin	17-20	tumor protein p53	Homo sapiens	39-42
19411846-9	2009	Specific inhibition of mitochondrial p53 translocation by Pifithrin mu reduces the apoptotic Nutlin response by 2.5-fold, underlining the significance of p53"s mitochondrial program in Nutlin-induced apoptosis.	pifithrin	58-67	tumor protein p53	Homo sapiens	37-40
19088112-7	2009	Inhibition of p53 with pifithrin alpha did not affect oogonia apoptosis following irradiation.	pifithrin	23-38	tumor protein p53	Homo sapiens	14-17
19155791-9	2009	In all diabetic cultures, inhibition of p53 by a specific inhibitor pifithrin concomitantly significantly decreased apoptosis.	pifithrin	68-77	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	40-43
19267667-1	2009	Pifithrin alpha (PFTalpha), one of the first known low molecular weight modulators of activity of tumor suppressor p53, increases survival of hemopoietic clonogenic cells (evaluated by the criterion of formation of endogenous spleen CFU-C8 colonies in irradiated animals).	pifithrin	0-15	tumor protein p53	Homo sapiens	115-118
19267667-1	2009	Pifithrin alpha (PFTalpha), one of the first known low molecular weight modulators of activity of tumor suppressor p53, increases survival of hemopoietic clonogenic cells (evaluated by the criterion of formation of endogenous spleen CFU-C8 colonies in irradiated animals).	pifithrin	17-25	tumor protein p53	Homo sapiens	115-118
19267667-4	2009	These included a parent compound, 2-ATBT (2-amino-4,5,6,7-tetrahydrobenzothiazole), which is used for synthesis of PFTalpha, and a product of its intramolecular cyclization under physiological conditions, cyclo-PFT (2-(4-methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole).	pifithrin	115-123	zinc finger homeobox 3	Homo sapiens	36-40
18923161-5	2009	Reduced viability was TRP53 dependent, being partially reversed by a TRP53 inhibitor (Pifithrin-alpha).	pifithrin	86-101	transformation related protein 53	Mus musculus	22-27
18923161-5	2009	Reduced viability was TRP53 dependent, being partially reversed by a TRP53 inhibitor (Pifithrin-alpha).	pifithrin	86-101	transformation related protein 53	Mus musculus	69-74
18459128-4	2009	Further, the treatment of A549 cells with pifithrin-alpha, a specific inhibitor of p53, or transfection of A549 cells with a p53 antisense oligodeoxynucleotide resulted in a reduction in the berberine-induced inhibition of cell proliferation and apoptosis.	pifithrin	42-51	tumor protein p53	Homo sapiens	83-86
18459128-4	2009	Further, the treatment of A549 cells with pifithrin-alpha, a specific inhibitor of p53, or transfection of A549 cells with a p53 antisense oligodeoxynucleotide resulted in a reduction in the berberine-induced inhibition of cell proliferation and apoptosis.	pifithrin	42-51	tumor protein p53	Homo sapiens	125-128
18834919-7	2008	HepG2 cell treatment with the p53 inhibitor pifithrin-alpha (PFT) and western blot analysis suggested that both ZEN and OTA, but not T-2 toxin, trigger a p53-dependent apoptotic pathway.	pifithrin	44-59	tumor protein p53	Homo sapiens	30-33
18834919-7	2008	HepG2 cell treatment with the p53 inhibitor pifithrin-alpha (PFT) and western blot analysis suggested that both ZEN and OTA, but not T-2 toxin, trigger a p53-dependent apoptotic pathway.	pifithrin	44-59	tumor protein p53	Homo sapiens	154-157
18847491-11	2008	Pretreatment of cells with pifithrin-alpha or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis.	pifithrin	27-42	tumor protein p53	Homo sapiens	76-79
18775851-6	2008	The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin.	pifithrin	156-165	mitogen activated protein kinase 3	Rattus norvegicus	29-35
18775851-6	2008	The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin.	pifithrin	156-165	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	40-43
18775851-6	2008	The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin.	pifithrin	156-165	Eph receptor B1	Rattus norvegicus	29-32
18775851-6	2008	The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin.	pifithrin	156-165	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	142-145
18775851-6	2008	The functional importance of ERK1/2 and p53 in doxorubicin-induced toxicity was further demonstrated by the specific ERK inhibitor U-0126 and p53 inhibitor pifithrin (PFT)-alpha, which abrogated the changes in Bcl-2 family proteins and cell death produced by doxorubicin.	pifithrin	156-165	BCL2, apoptosis regulator	Rattus norvegicus	210-215
18317410-4	2008	Published data from our laboratory demonstrated that pretreatment of MI/R rats with pifithrin-alpha (PFT), a specific p53 inhibitor, reduced myocyte apoptosis and improved cardiac function compared with MI/R rats pretreated with saline at 4 h of reperfusion.	pifithrin	84-93	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	118-121
18557930-6	2008	In contrast, p53 inhibitor, pifithrin-alpha augmented the UV-induced MMP-1 expression.	pifithrin	28-43	matrix metallopeptidase 1	Homo sapiens	69-74
18660518-8	2008	However, the function of pifithrin-alpha in this model may act as a competitive inhibitor of PCB at the AHR and is likely independent of p53.	pifithrin	25-40	aryl hydrocarbon receptor 1a	Danio rerio	104-107
18847491-11	2008	Pretreatment of cells with pifithrin-alpha or U0126, specific inhibitors of p53 or MEK-1/2, significantly attenuated Triphala-induced apoptosis.	pifithrin	27-42	mitogen-activated protein kinase kinase 1	Homo sapiens	83-90
18509315-5	2008	Notably, autophagy occurred within hours of cisplatin administration but this was partially suppressed by the p53 inhibitor pifithrin-alpha, suggesting that p53 is involved in autophagic signaling.	pifithrin	124-133	transformation related protein 53, pseudogene	Mus musculus	110-113
18628404-7	2008	Pifithrin-alpha, an inhibitor of the tumor suppressor protein p53, had no effect on ROS generation but did block alpha1D-AR-induced apoptosis.	pifithrin	0-15	tumor protein p53	Homo sapiens	62-65
18813780-11	2008	Incubation with either the irreversible pan-caspase inhibitors Z-VAD-FMK, or SP600125, a selective inhibitor of JNK, or pifithrin alpha, a potent p53 inhibitor, significantly inhibited the effects induced by PTX.	pifithrin	120-135	tumor protein p53	Homo sapiens	146-149
18509315-5	2008	Notably, autophagy occurred within hours of cisplatin administration but this was partially suppressed by the p53 inhibitor pifithrin-alpha, suggesting that p53 is involved in autophagic signaling.	pifithrin	124-133	transformation related protein 53, pseudogene	Mus musculus	157-160
17960385-10	2008	An inhibitor of p53, pifithrin-alpha, antagonized the expression of the cleaved form of caspase-3 in MKN45 cells.	pifithrin	21-30	tumor protein p53	Homo sapiens	16-19
17960385-10	2008	An inhibitor of p53, pifithrin-alpha, antagonized the expression of the cleaved form of caspase-3 in MKN45 cells.	pifithrin	21-30	caspase 3	Homo sapiens	88-97
18547707-10	2008	Pifithrin alpha, a p53 transcriptional inhibitor, increases Cr (VI) cytotoxicity, suggesting a role of p53 as a survival molecule.	pifithrin	0-15	tumor protein p53	Homo sapiens	19-22
18547707-10	2008	Pifithrin alpha, a p53 transcriptional inhibitor, increases Cr (VI) cytotoxicity, suggesting a role of p53 as a survival molecule.	pifithrin	0-15	tumor protein p53	Homo sapiens	103-106
18448277-5	2008	Inhibition of p53 by either its inhibitor pifithrin-alpha or p53 siRNA markedly increased B(a)P-induced the activation of c-Jun, Akt and ERK in this context.	pifithrin	42-51	tumor protein p53	Homo sapiens	14-17
18550754-3	2008	Myelin preservation, decreased microglial recruitment, and gene expression were observed in mice lacking p53 or receiving systemic administration of the p53 inhibitor pifithrin-alpha, compared with untreated controls.	pifithrin	167-182	transformation related protein 53, pseudogene	Mus musculus	153-156
18084327-4	2008	Interestingly, more pronounced tumoricidal effects were observed in p53-deficient HCT116 and HT29 cells, as well as A549 cells treated with the p53 inhibitor cyclic pifithrin-alpha.	pifithrin	165-180	tumor protein p53	Homo sapiens	68-71
18084327-4	2008	Interestingly, more pronounced tumoricidal effects were observed in p53-deficient HCT116 and HT29 cells, as well as A549 cells treated with the p53 inhibitor cyclic pifithrin-alpha.	pifithrin	165-180	tumor protein p53	Homo sapiens	144-147
18342637-6	2008	All these effects were significantly blocked by pretreatment of cells with the antioxidant N-acetylcysteine, p53 inhibitor pifithrin-alpha, and enzyme catalase.	pifithrin	123-138	tumor protein p53	Homo sapiens	109-112
18448277-5	2008	Inhibition of p53 by either its inhibitor pifithrin-alpha or p53 siRNA markedly increased B(a)P-induced the activation of c-Jun, Akt and ERK in this context.	pifithrin	42-51	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	122-127
18448277-5	2008	Inhibition of p53 by either its inhibitor pifithrin-alpha or p53 siRNA markedly increased B(a)P-induced the activation of c-Jun, Akt and ERK in this context.	pifithrin	42-51	mitogen-activated protein kinase 1	Homo sapiens	137-140
18418056-5	2008	By contrast, a pharmacological inhibitor of p53 function [Pifithrin-alpha(PFTalpha)] caused developmental abnormalities affecting the head, brain, eyes and kidney function and did not protect against lethal effects of ionizing radiation when administered at 3 hours post fertilization (hpf).	pifithrin	58-73	tumor protein p53	Danio rerio	44-47
18374905-15	2008	Furthermore, p53 inhibitor pifithrin-alpha partially nullified the suppressive effects of SP600125 on PS1 expression.	pifithrin	27-42	tumor protein p53	Homo sapiens	13-16
18374905-15	2008	Furthermore, p53 inhibitor pifithrin-alpha partially nullified the suppressive effects of SP600125 on PS1 expression.	pifithrin	27-42	presenilin 1	Homo sapiens	102-105
18418056-5	2008	By contrast, a pharmacological inhibitor of p53 function [Pifithrin-alpha(PFTalpha)] caused developmental abnormalities affecting the head, brain, eyes and kidney function and did not protect against lethal effects of ionizing radiation when administered at 3 hours post fertilization (hpf).	pifithrin	74-82	tumor protein p53	Danio rerio	44-47
18418056-7	2008	PFTalpha also inhibited p73-dependent transcription of a reporter gene construct containing canonical p53-responsive promoter sequences.	pifithrin	0-8	tumor protein p53	Danio rerio	102-105
18418056-9	2008	In summary, this study highlights off-target effects of the pharmacological p53 inhibitor PFTalpha related to inhibition of p73 function and essential roles of p73 at early but not later stages of zebrafish development.	pifithrin	90-98	tumor protein p53	Danio rerio	76-79
18344606-4	2008	Pifithrin-alpha, a p53 inhibitor, significantly prevented trimidox-induced apoptotic characteristics, as detected by nuclear morphological observation and DNA fragmentation.	pifithrin	0-15	tumor protein p53	Homo sapiens	19-22
18248609-6	2008	The p53 inhibitor, pifithrin-alpha and small interfering RNA-mediated knockdown of p53 prevented the Delta9-THC-mediated increase in lysosomal permeability.	pifithrin	19-28	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	83-86
18293087-3	2008	Translocation of AIF was preceded by p53 phosphorylation at Ser15 and blocked by pifithrin alpha, a known inhibitor of p53-transcriptional activity.	pifithrin	81-96	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	17-20
18293087-3	2008	Translocation of AIF was preceded by p53 phosphorylation at Ser15 and blocked by pifithrin alpha, a known inhibitor of p53-transcriptional activity.	pifithrin	81-96	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	119-122
17965848-5	2008	Consequential decrease in cell viability was in part prevented by the p53 inhibitor pifithrin-alpha, suggesting that p53 translocation contributes to QD-induced cytotoxicity.	pifithrin	84-99	tumor protein p53	Homo sapiens	70-73
17965848-5	2008	Consequential decrease in cell viability was in part prevented by the p53 inhibitor pifithrin-alpha, suggesting that p53 translocation contributes to QD-induced cytotoxicity.	pifithrin	84-99	tumor protein p53	Homo sapiens	117-120
18097557-5	2008	Experiments performed using pifithrin-alpha, a reversible inhibitor of p53, showed a correlation between acetylation of p53 and induction of apoptosis.	pifithrin	28-43	tumor protein p53	Homo sapiens	71-74
17846083-5	2008	Apoptosis was prevented by the p53 inhibitor pifithrin and by p53 antisense oligonucleotides, indicating dependency of force-induced apoptosis on p53.	pifithrin	45-54	tumor protein p53	Homo sapiens	31-34
18097557-5	2008	Experiments performed using pifithrin-alpha, a reversible inhibitor of p53, showed a correlation between acetylation of p53 and induction of apoptosis.	pifithrin	28-43	tumor protein p53	Homo sapiens	120-123
17670903-6	2007	Pifithrin-alpha, a pharmacological inhibitor of p53, suppressed p53 activation and ameliorated kidney injury during cisplatin treatment.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	48-51
17673346-2	2007	The aim of this study was to investigate the effect of pifithrin-alpha (PFTalpha; a specific p53 inhibitor) and mitogen-activated protein kinases (MAPKs) inhibitors [namely SP600125 (a specific JNK inhibitor), SB203580 (a specific p38 inhibitor) and PD98059 (a specific ERK inhibitor)] on apoptotic signaling transduction mechanism induced by Cin in human hepatoma PLC/PRF/5 (CD95-negative) cells.	pifithrin	72-80	tumor protein p53	Homo sapiens	93-96
17673346-8	2007	The activities of anti-apoptotic (Bcl-(XL)) and pro-apoptotic (Bax) proteins were remarkably affected by PFTalpha and PD98059 pre-treatment.	pifithrin	105-113	BCL2 like 1	Homo sapiens	34-42
17673346-8	2007	The activities of anti-apoptotic (Bcl-(XL)) and pro-apoptotic (Bax) proteins were remarkably affected by PFTalpha and PD98059 pre-treatment.	pifithrin	105-113	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
17673346-9	2007	PFTalpha effectively blocked PARP cleavage in cells treated with Cin, and also markedly prevented the phosphorylation of JNK, p38 and ERK proteins.	pifithrin	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	29-33
17673346-9	2007	PFTalpha effectively blocked PARP cleavage in cells treated with Cin, and also markedly prevented the phosphorylation of JNK, p38 and ERK proteins.	pifithrin	0-8	mitogen-activated protein kinase 8	Homo sapiens	121-124
17673346-9	2007	PFTalpha effectively blocked PARP cleavage in cells treated with Cin, and also markedly prevented the phosphorylation of JNK, p38 and ERK proteins.	pifithrin	0-8	mitogen-activated protein kinase 14	Homo sapiens	126-129
17673346-9	2007	PFTalpha effectively blocked PARP cleavage in cells treated with Cin, and also markedly prevented the phosphorylation of JNK, p38 and ERK proteins.	pifithrin	0-8	mitogen-activated protein kinase 1	Homo sapiens	134-137
17855337-6	2007	Furthermore, RNA interference-mediated lowering of the p53 protein in T1 cells or pifithrin-alpha-induced p53-specific inhibition activity significantly decreased CTL-induced target killing mediated by CTL or recombinant GrB.	pifithrin	82-91	tumor protein p53	Homo sapiens	106-109
17855337-6	2007	Furthermore, RNA interference-mediated lowering of the p53 protein in T1 cells or pifithrin-alpha-induced p53-specific inhibition activity significantly decreased CTL-induced target killing mediated by CTL or recombinant GrB.	pifithrin	82-91	granzyme B	Homo sapiens	221-224
17855337-9	2007	Treatment of T1 cells with pifithrin-alpha resulted in inhibition of p53 phosphorylation at these residues and in a significant decrease in GrB-induced apoptotic T1 cell death.	pifithrin	27-36	tumor protein p53	Homo sapiens	69-72
17855337-9	2007	Treatment of T1 cells with pifithrin-alpha resulted in inhibition of p53 phosphorylation at these residues and in a significant decrease in GrB-induced apoptotic T1 cell death.	pifithrin	27-36	granzyme B	Homo sapiens	140-143
17855051-3	2007	In this study, we show that Bax translocation, caspase-3 activation and cell death by UV irradiation are not affected by Z-IETD-fmk (caspase-8 inhibitor), but delayed by Pifithrin-alpha (p53 inhibitor), although Bid cleavage could be completely abolished by Z-IETD-fmk.	pifithrin	170-179	BCL2 associated X, apoptosis regulator	Homo sapiens	28-31
17855051-3	2007	In this study, we show that Bax translocation, caspase-3 activation and cell death by UV irradiation are not affected by Z-IETD-fmk (caspase-8 inhibitor), but delayed by Pifithrin-alpha (p53 inhibitor), although Bid cleavage could be completely abolished by Z-IETD-fmk.	pifithrin	170-179	tumor protein p53	Homo sapiens	187-190
17968428-6	2007	To verify the role of p53, the assays were repeated in presence of pifithrin-alpha, an inhibitor of p53.	pifithrin	67-82	tumor protein p53	Homo sapiens	100-103
17670903-6	2007	Pifithrin-alpha, a pharmacological inhibitor of p53, suppressed p53 activation and ameliorated kidney injury during cisplatin treatment.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	64-67
17630850-5	2007	The p53 inhibitor pifithrin did not block GSNO-induced cell death.	pifithrin	18-27	tumor protein p53	Homo sapiens	4-7
17505786-5	2007	Moreover, the presence of pifithrin-alpha, an inhibitor of p53 transcriptional activity, blocked cisplatin-induced apoptosis, reduced the generation of ROS produced upon cisplatin treatment.	pifithrin	26-41	tumor protein p53	Homo sapiens	59-62
17464322-4	2007	Post-traumatic neurodegeneration correlated with the increase in p53 levels and was significantly reduced by the selective p53 inhibitor pifithrin-alpha (PFT).	pifithrin	137-152	transformation related protein 53, pseudogene	Mus musculus	65-68
17464322-4	2007	Post-traumatic neurodegeneration correlated with the increase in p53 levels and was significantly reduced by the selective p53 inhibitor pifithrin-alpha (PFT).	pifithrin	137-152	transformation related protein 53, pseudogene	Mus musculus	123-126
17368433-8	2007	SN50 and the p53 antagonist pifithrin-alpha significantly reduced nigral dopaminergic neuron degeneration.	pifithrin	28-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	13-16
17456577-13	2007	Finally, when we added pifithrin-alpha, a specific inhibitor of p53 functions, a significant decrease in irradiation-induced apoptosis in both germ and Sertoli cells was observed, indicating the involvement of the p53 pathway in irradiation-induced apoptosis.	pifithrin	23-38	tumor protein p53	Homo sapiens	64-67
17456577-13	2007	Finally, when we added pifithrin-alpha, a specific inhibitor of p53 functions, a significant decrease in irradiation-induced apoptosis in both germ and Sertoli cells was observed, indicating the involvement of the p53 pathway in irradiation-induced apoptosis.	pifithrin	23-38	tumor protein p53	Homo sapiens	214-217
17434459-6	2007	Evidence of a causative role for p53 in spinal cord cell death was provided by use of a p53 inhibitor, pifithrin-alpha, in organotypic slice cultures of mouse spinal cord.	pifithrin	103-118	transformation related protein 53, pseudogene	Mus musculus	33-36
17434459-6	2007	Evidence of a causative role for p53 in spinal cord cell death was provided by use of a p53 inhibitor, pifithrin-alpha, in organotypic slice cultures of mouse spinal cord.	pifithrin	103-118	transformation related protein 53, pseudogene	Mus musculus	88-91
16968891-9	2007	Targeting p21 via the selective p53 inhibitor pifithrin-alpha was able to prevent acute renal failure when administered immediately before ischemia.	pifithrin	46-55	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	10-13
17340621-11	2007	In addition, inhibition of CD95/Fas receptor on the cell surface of MCF-EGFP cells by treatment with Pifithrin-alpha, a p53 specific transactivation inhibitor, partially abrogated the sensitivity of bystander MCF-EGFP cells.	pifithrin	101-116	Fas cell surface death receptor	Homo sapiens	27-31
17340621-11	2007	In addition, inhibition of CD95/Fas receptor on the cell surface of MCF-EGFP cells by treatment with Pifithrin-alpha, a p53 specific transactivation inhibitor, partially abrogated the sensitivity of bystander MCF-EGFP cells.	pifithrin	101-116	tumor protein p53	Homo sapiens	120-123
16936710-6	2007	In addition, the increased expression of DR5 receptor after beta amyloid treatment was sustained by p53 transcriptional activity, as demonstrated by the data showing that the p53 inhibitor Pifithrin alpha prevented both beta amyloid-induced DR5 induction and cell death.	pifithrin	189-204	tumor protein p53	Homo sapiens	100-103
16936710-6	2007	In addition, the increased expression of DR5 receptor after beta amyloid treatment was sustained by p53 transcriptional activity, as demonstrated by the data showing that the p53 inhibitor Pifithrin alpha prevented both beta amyloid-induced DR5 induction and cell death.	pifithrin	189-204	tumor protein p53	Homo sapiens	175-178
16936710-6	2007	In addition, the increased expression of DR5 receptor after beta amyloid treatment was sustained by p53 transcriptional activity, as demonstrated by the data showing that the p53 inhibitor Pifithrin alpha prevented both beta amyloid-induced DR5 induction and cell death.	pifithrin	189-204	TNF receptor superfamily member 10b	Homo sapiens	41-44
16968891-9	2007	Targeting p21 via the selective p53 inhibitor pifithrin-alpha was able to prevent acute renal failure when administered immediately before ischemia.	pifithrin	46-55	transformation related protein 53, pseudogene	Mus musculus	32-35
17487067-0	2007	Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.	pifithrin	148-157	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
16902184-0	2007	Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury.	pifithrin	0-15	tumor protein p53	Homo sapiens	33-36
16902184-2	2007	The goal of this study was to evaluate the effect of a p53 transactivation inhibitor, namely, pifithrin-alpha, on the pathophysiological sequence following collagenase-induced tendon injury.	pifithrin	94-109	tumor protein p53	Homo sapiens	55-58
17487067-0	2007	Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.	pifithrin	148-157	KRAS proto-oncogene, GTPase	Rattus norvegicus	52-55
17487067-0	2007	Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.	pifithrin	148-157	BCL2, apoptosis regulator	Rattus norvegicus	57-61
17487067-0	2007	Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.	pifithrin	148-157	proliferating cell nuclear antigen	Rattus norvegicus	63-67
17487067-0	2007	Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.	pifithrin	148-157	cyclin G1	Rattus norvegicus	69-77
17487067-0	2007	Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.	pifithrin	148-157	MDM2 proto-oncogene	Rattus norvegicus	83-87
16982703-6	2006	Preincubation of KMCH cells with pifithrin-alpha enhanced gemcitabine-induced cytotoxicity in an eIF-4E-dependent manner.	pifithrin	33-42	eukaryotic translation initiation factor 4E	Homo sapiens	97-103
17341629-6	2006	Pifithrin-alpha (PFT), an inhibitor of p53 transcriptional activity, protected only NB4 cells with functional p53 from FK228-induced apoptosis and did not interfere with antiproliferative activity in p53-negative HL-60 cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	39-42
17341629-6	2006	Pifithrin-alpha (PFT), an inhibitor of p53 transcriptional activity, protected only NB4 cells with functional p53 from FK228-induced apoptosis and did not interfere with antiproliferative activity in p53-negative HL-60 cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	110-113
17341629-6	2006	Pifithrin-alpha (PFT), an inhibitor of p53 transcriptional activity, protected only NB4 cells with functional p53 from FK228-induced apoptosis and did not interfere with antiproliferative activity in p53-negative HL-60 cells.	pifithrin	0-15	tumor protein p53	Homo sapiens	110-113
16982703-8	2006	Pifithrin-alpha was shown to activate aryl hydrocarbon receptor (AhR) signaling and p38 MAPK activation.	pifithrin	0-15	aryl hydrocarbon receptor	Homo sapiens	38-63
16982703-8	2006	Pifithrin-alpha was shown to activate aryl hydrocarbon receptor (AhR) signaling and p38 MAPK activation.	pifithrin	0-15	aryl hydrocarbon receptor	Homo sapiens	65-68
17060322-5	2006	Inhibition of p53 by pifithrin-alpha or by RNA interference prevented mitochondrial membrane permeabilization and cytotoxicity.	pifithrin	21-30	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	14-17
16971506-7	2006	The p53 inhibitor pifithrin-alpha protects HepG2 cells against apoptosis induced by serum withdrawal.	pifithrin	18-33	tumor protein p53	Homo sapiens	4-7
16982703-10	2006	Pifithrin-alpha enhanced chemosensitivity by a mechanism independent of p53 and involving AhR and p38 MAPK deregulation of eIF-4E phosphorylation.	pifithrin	0-9	tumor protein p53	Homo sapiens	72-75
16982703-10	2006	Pifithrin-alpha enhanced chemosensitivity by a mechanism independent of p53 and involving AhR and p38 MAPK deregulation of eIF-4E phosphorylation.	pifithrin	0-9	aryl hydrocarbon receptor	Homo sapiens	90-93
16647569-11	2006	CONCLUSIONS: These data indicate that Trp53 loss-of-function could partly explain the acquisition of AML chemoresistance, and suggest that PFTalpha could be useful in treatment of relapsed AML.	pifithrin	139-147	transformation related protein 53	Mus musculus	38-43
16982703-10	2006	Pifithrin-alpha enhanced chemosensitivity by a mechanism independent of p53 and involving AhR and p38 MAPK deregulation of eIF-4E phosphorylation.	pifithrin	0-9	eukaryotic translation initiation factor 4E	Homo sapiens	123-129
16777994-5	2006	Pifithrin-alpha, a p53 inhibitor, reversed silibinin-induced caspase activation including caspase 2; however, caspase 2 inhibitor also reversed p53 phosphorylation suggesting a bidirectional regulation between them.	pifithrin	0-15	tumor protein p53	Homo sapiens	19-22
16777994-5	2006	Pifithrin-alpha, a p53 inhibitor, reversed silibinin-induced caspase activation including caspase 2; however, caspase 2 inhibitor also reversed p53 phosphorylation suggesting a bidirectional regulation between them.	pifithrin	0-15	caspase 2	Homo sapiens	90-99
16844116-6	2006	Pretreatment with p53 inhibitor pifithrin alpha cancelled the IR-induced downregulation of FAP-1 mRNA.	pifithrin	32-41	tumor protein p53	Homo sapiens	18-21
16844116-6	2006	Pretreatment with p53 inhibitor pifithrin alpha cancelled the IR-induced downregulation of FAP-1 mRNA.	pifithrin	32-41	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	91-96
17018587-7	2006	A similar effect was achieved when anticancer treatment was combined with pharmacologic suppression of p53 by the cyclic form of pifithrin alpha, a small-molecule inhibitor of p53.	pifithrin	129-144	transformation related protein 53, pseudogene	Mus musculus	103-106
17018587-7	2006	A similar effect was achieved when anticancer treatment was combined with pharmacologic suppression of p53 by the cyclic form of pifithrin alpha, a small-molecule inhibitor of p53.	pifithrin	129-144	transformation related protein 53, pseudogene	Mus musculus	176-179
16135398-5	2006	Moreover, TPL inhibited the clonogenic growth of MCF 7 cells, which was significantly recovered by pifithrin-alpha, the p53 inhibitor.	pifithrin	99-114	tumor protein p53	Homo sapiens	120-123
16778187-8	2006	The p53 inhibitor, pifithrin-alpha, is able to attenuate the effect of proteasome inhibition.	pifithrin	19-34	tumor protein p53	Homo sapiens	4-7
16288207-9	2006	Pretreatment with the specific p53 inhibitor pifithrin or downregulation of p53 using a specific small inhibitory RNA significantly attenuated ODQ-induced apoptosis.	pifithrin	45-54	tumor protein p53	Homo sapiens	31-34
16357363-6	2006	Further, pifithrin, E6, phytic acid, or rho(0)-A549 cells (cells incapable of mitochondrial reactive oxygen species production) block asbestos-induced p53 activation.	pifithrin	9-18	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	151-154
16303760-10	2006	Inactivation of this "heat-shock element" by either site-directed mutation or an HSF1 inhibitor, pifithrin-alpha, restored the promoter activity of the silencer structure.	pifithrin	97-112	heat shock transcription factor 1	Homo sapiens	81-85
16005925-6	2006	Pifithrin-alpha, inhibitor of p53 transcriptional activity, prevented induction of apoptosis and activation of ERK1/2 and p38.	pifithrin	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	30-33
16005925-6	2006	Pifithrin-alpha, inhibitor of p53 transcriptional activity, prevented induction of apoptosis and activation of ERK1/2 and p38.	pifithrin	0-15	mitogen activated protein kinase 3	Rattus norvegicus	111-117
16005925-6	2006	Pifithrin-alpha, inhibitor of p53 transcriptional activity, prevented induction of apoptosis and activation of ERK1/2 and p38.	pifithrin	0-15	mitogen activated protein kinase 14	Rattus norvegicus	122-125
16467109-7	2006	Radiosensitization of cells expressing p53 by TSA was reduced by pifithrin-alpha, a small-molecule inhibitor of p53.	pifithrin	65-80	tumor protein p53	Homo sapiens	39-42
16467109-7	2006	Radiosensitization of cells expressing p53 by TSA was reduced by pifithrin-alpha, a small-molecule inhibitor of p53.	pifithrin	65-80	tumor protein p53	Homo sapiens	112-115
16204064-7	2005	Treatment of p53 wild-type cells with pifithrin-alpha, an inhibitor of the trans-activating activity of p53, caused reversal of the phenotype, making wild-type cells more sensitive to topotecan.	pifithrin	38-53	tumor protein p53	Homo sapiens	13-16
17065086-1	2006	Previously, we have found that activation of deoxycytidine kinase elicited by various DNA-damaging chemical agents could be prevented by BAPTA-AM, a cell-permeable calcium chelator or by pifithrin-alpha, a pharmacological inhibitor of p53.	pifithrin	187-202	tumor protein p53	Homo sapiens	235-238
16204041-8	2005	Intact global NER was also confirmed in SCC25 cells possessing inactivating mutations in p53 as well as in cells treated with pifithrin-alpha, a chemical inhibitor of p53 that decreased sensitivity of cells to UV radiation.	pifithrin	126-141	tumor protein p53	Homo sapiens	167-170
16204064-7	2005	Treatment of p53 wild-type cells with pifithrin-alpha, an inhibitor of the trans-activating activity of p53, caused reversal of the phenotype, making wild-type cells more sensitive to topotecan.	pifithrin	38-53	tumor protein p53	Homo sapiens	104-107
16005638-6	2005	Moreover, gp120 neurotoxicity is markedly reduced by the p53-inhibitor, pifithrin-alpha.	pifithrin	72-87	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	10-15
15983031-4	2005	Pancaspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone or p53 inhibitor pifithrin-alpha markedly prevented mitochondrial release of AIF, suggesting that caspases and p53 are involved in this release.	pifithrin	87-102	tumor protein p53	Homo sapiens	73-76
15983031-4	2005	Pancaspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone or p53 inhibitor pifithrin-alpha markedly prevented mitochondrial release of AIF, suggesting that caspases and p53 are involved in this release.	pifithrin	87-102	apoptosis inducing factor mitochondria associated 1	Homo sapiens	147-150
15983031-4	2005	Pancaspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone or p53 inhibitor pifithrin-alpha markedly prevented mitochondrial release of AIF, suggesting that caspases and p53 are involved in this release.	pifithrin	87-102	caspase 2	Homo sapiens	168-176
15983031-4	2005	Pancaspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone or p53 inhibitor pifithrin-alpha markedly prevented mitochondrial release of AIF, suggesting that caspases and p53 are involved in this release.	pifithrin	87-102	tumor protein p53	Homo sapiens	181-184
15983031-10	2005	The p53 inhibitor pifithrin-alpha or p53 siRNA prevented both cisplatin-induced caspase-2 activation and mitochondrial release of AIF.	pifithrin	18-27	tumor protein p53	Homo sapiens	4-7
15983031-10	2005	The p53 inhibitor pifithrin-alpha or p53 siRNA prevented both cisplatin-induced caspase-2 activation and mitochondrial release of AIF.	pifithrin	18-27	caspase 2	Homo sapiens	80-89
15983031-10	2005	The p53 inhibitor pifithrin-alpha or p53 siRNA prevented both cisplatin-induced caspase-2 activation and mitochondrial release of AIF.	pifithrin	18-27	apoptosis inducing factor mitochondria associated 1	Homo sapiens	130-133
16005638-6	2005	Moreover, gp120 neurotoxicity is markedly reduced by the p53-inhibitor, pifithrin-alpha.	pifithrin	72-87	tumor protein p53	Homo sapiens	57-60
16061640-3	2005	In the present study, we found that pretreatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcriptional activation, resulted in a marked increase in UV-induced activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pifithrin	84-99	transformation related protein 53, pseudogene	Mus musculus	118-121
15976193-6	2005	The p53 inhibitor PFTalpha reduced both DON-induced phosphorylation of p53 and p53 binding activity.	pifithrin	18-26	tumor protein p53	Homo sapiens	4-7
15976193-6	2005	The p53 inhibitor PFTalpha reduced both DON-induced phosphorylation of p53 and p53 binding activity.	pifithrin	18-26	tumor protein p53	Homo sapiens	71-74
15976193-6	2005	The p53 inhibitor PFTalpha reduced both DON-induced phosphorylation of p53 and p53 binding activity.	pifithrin	18-26	tumor protein p53	Homo sapiens	71-74
15976193-7	2005	Moreover, both PFTalpha and p53 siRNA transfection suppressed DON-induced caspase-3 activity and subsequent DNA fragmentation.	pifithrin	15-23	caspase 3	Homo sapiens	74-83
16170037-7	2005	The use of the chemical inhibitor of p53, pifithrin alpha, excluded this possibility.	pifithrin	42-51	tumor protein p53	Homo sapiens	37-40
15800902-1	2005	Pifithrin-alpha (PFTalpha) is a small molecule inhibitor of p53.	pifithrin	0-15	tumor protein p53	Homo sapiens	60-63
15800902-1	2005	Pifithrin-alpha (PFTalpha) is a small molecule inhibitor of p53.	pifithrin	17-25	tumor protein p53	Homo sapiens	60-63
15800902-5	2005	We observed that exposure of U87MG cells to PFTalpha before cytotoxic chemotherapy attenuated p53-mediated induction of p21WAF1 protein levels, sensitizing U87MG cells to BCNU and TMZ.	pifithrin	44-52	tumor protein p53	Homo sapiens	94-97
15800902-7	2005	Our findings suggest that in addition to protecting normal cells from the toxic effects of radiation and chemotherapy, small molecule inhibitors of p53, like PFTalpha, might play a role in clinical oncology by sensitizing certain resistant cancers to cytotoxic chemotherapies.	pifithrin	158-166	tumor protein p53	Homo sapiens	148-151
16061640-3	2005	In the present study, we found that pretreatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcriptional activation, resulted in a marked increase in UV-induced activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pifithrin	84-99	jun proto-oncogene	Mus musculus	218-237
16061640-3	2005	In the present study, we found that pretreatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcriptional activation, resulted in a marked increase in UV-induced activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pifithrin	84-99	jun proto-oncogene	Mus musculus	239-243
16061640-3	2005	In the present study, we found that pretreatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcriptional activation, resulted in a marked increase in UV-induced activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pifithrin	84-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	264-270
16061640-3	2005	In the present study, we found that pretreatment of mouse epidermal Cl41 cells with pifithrin-alpha, an inhibitor for p53-dependent transcriptional activation, resulted in a marked increase in UV-induced activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).	pifithrin	84-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	272-281
15729295-3	2005	Twenty mongrel dogs were divided into four groups: (1) control, (2) SAH, (3) SAH+DMSO (vehicle), and (4) SAH+pifithrin-alpha (PFT) (p53 inhibitor).	pifithrin	109-124	tumor protein p53	Canis lupus familiaris	132-135
15843497-0	2005	The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.	pifithrin	18-33	tumor protein p53	Homo sapiens	4-7
15843497-0	2005	The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.	pifithrin	18-33	aryl hydrocarbon receptor	Homo sapiens	61-86
15818399-7	2005	Fas decoy, TSP1 receptor antibody and Pifithrin, a p53 inhibitor, severely decreased apoptosis and restored angiogenesis by DXR-DI-TSP combination, evidencing critical roles of CD95 and TSP1.	pifithrin	38-47	transformation related protein 53, pseudogene	Mus musculus	51-54
15818399-7	2005	Fas decoy, TSP1 receptor antibody and Pifithrin, a p53 inhibitor, severely decreased apoptosis and restored angiogenesis by DXR-DI-TSP combination, evidencing critical roles of CD95 and TSP1.	pifithrin	38-47	Fas (TNF receptor superfamily member 6)	Mus musculus	177-181
15818399-7	2005	Fas decoy, TSP1 receptor antibody and Pifithrin, a p53 inhibitor, severely decreased apoptosis and restored angiogenesis by DXR-DI-TSP combination, evidencing critical roles of CD95 and TSP1.	pifithrin	38-47	thrombospondin 1	Mus musculus	186-190
15865929-3	2005	This strategy was validated by isolation and testing of small molecule p53 inhibitor pifithrin-alpha that demonstrated broad tissue protecting capacity.	pifithrin	85-100	tumor protein p53	Homo sapiens	71-74
15315938-7	2004	Of interest, cisplatin-induced apoptosis was also suppressed by pifithrin-alpha, a pharmacological inhibitor of p53.	pifithrin	64-79	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	112-115
16216017-8	2005	Addition of pifithrin-alpha, a p53 inhibitor, or expression of a dominant-negative p53 rescued neurons from kainate-induced excitotoxic cell death in primary cortical cultures derived from wildtype, DNA-PKcs heterozygous, or DNA-PKcs null neonatal mice.	pifithrin	12-27	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	199-207
15547111-7	2005	Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR.	pifithrin	19-28	tumor protein p53	Homo sapiens	60-63
15547111-7	2005	Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR.	pifithrin	19-28	growth arrest and DNA damage inducible alpha	Homo sapiens	84-90
15547111-7	2005	Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR.	pifithrin	19-28	BCL2 apoptosis regulator	Homo sapiens	92-96
15547111-7	2005	Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR.	pifithrin	19-28	cyclin B1	Homo sapiens	98-107
15547111-7	2005	Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR.	pifithrin	19-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	113-116
15547111-7	2005	Co-incubation with pifithrin-alpha (PFT-alpha), a selective p53 inhibitor, restored GADD45, Bcl2, cyclin B1, and p21(WAF1) expression levels and almost completely reversed the growth inhibitory, cell cycle, and apoptotic effects of 5-aza-CR.	pifithrin	19-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	117-121
15548639-9	2005	Pifithrin-alpha, a synthetic inhibitor of p53 activity, abolished both S-phase arrest and apoptosis induced by genotoxic PAHs, and it potentiated the proliferative effect of BaP.	pifithrin	0-15	tumor protein p53	Homo sapiens	42-45
15548639-9	2005	Pifithrin-alpha, a synthetic inhibitor of p53 activity, abolished both S-phase arrest and apoptosis induced by genotoxic PAHs, and it potentiated the proliferative effect of BaP.	pifithrin	0-15	prohibitin 2	Homo sapiens	174-177
15315938-10	2004	The p53 activation was blocked by pifithrin-alpha, but not by VAD.	pifithrin	34-49	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	4-7
15252149-10	2004	Attenuating p53 by a chemical inhibitor pifithrin-alpha decreased the selenite-induced p53 Ser15P and led to concordant reductions of PARP cleavage and apoptosis.	pifithrin	40-49	tumor protein p53	Homo sapiens	12-15
15378026-7	2004	Activation of endogenous wt p53 in BLs and lymphoblastoid cell lines led to the induction of SAP and this was inhibited by the specific p53 inhibitor pifithrin-alpha.	pifithrin	150-165	tumor protein p53	Homo sapiens	28-31
15378026-7	2004	Activation of endogenous wt p53 in BLs and lymphoblastoid cell lines led to the induction of SAP and this was inhibited by the specific p53 inhibitor pifithrin-alpha.	pifithrin	150-165	SH2 domain containing 1A	Homo sapiens	93-96
15378026-7	2004	Activation of endogenous wt p53 in BLs and lymphoblastoid cell lines led to the induction of SAP and this was inhibited by the specific p53 inhibitor pifithrin-alpha.	pifithrin	150-165	tumor protein p53	Homo sapiens	136-139
15302096-7	2004	Pifithrin-alpha, a chemical inhibitor of wild-type p53, ameliorated the cytotoxicity of Ara-C in NALM-6 and MOLT-4, but not Jurkat, U937 or HL-60.	pifithrin	0-15	tumor protein p53	Homo sapiens	51-54
15331571-6	2004	Treatment of nonluteinized macaque granulosa cells with hCG and the p53 inhibitor pifithrin-alpha (PFT) in vitro did not alter markers of the cell cycle, including proliferating cell nuclear antigen, p21, and human double minute (HDM)-2 expression compared with hCG alone.	pifithrin	82-97	tumor protein p53	Homo sapiens	68-71
15498930-8	2004	Furthermore, the low-dose hypersensitivity and Annexin V binding to irradiated A549 and T98G cells were eliminated by treating the cells with pifithrin, an inhibitor of p53.	pifithrin	142-151	annexin A5	Homo sapiens	47-56
15498930-8	2004	Furthermore, the low-dose hypersensitivity and Annexin V binding to irradiated A549 and T98G cells were eliminated by treating the cells with pifithrin, an inhibitor of p53.	pifithrin	142-151	tumor protein p53	Homo sapiens	169-172
15145929-1	2004	Pifithrin-alpha (PFTalpha) was originally thought to be a specific inhibitor of signaling by the tumor suppressor protein p53.	pifithrin	0-15	tumor protein p53	Homo sapiens	122-125
15145929-1	2004	Pifithrin-alpha (PFTalpha) was originally thought to be a specific inhibitor of signaling by the tumor suppressor protein p53.	pifithrin	17-25	tumor protein p53	Homo sapiens	122-125
15145929-2	2004	However, the laboratory that discovered pifithrin recently reported that the compound also inhibits heat shock and glucocorticoid receptor (GR) signaling, and they suggested that PFTalpha targets a factor common to all three signal transduction pathways, such as the hsp90/hsp70-based chaperone machinery (Komarova, E. A., Neznanov, N., Komarov, P. G., Chernov, M. V., Wang, K., and Gudkov, A. V. (2003) J. Biol.	pifithrin	40-49	nuclear receptor subfamily 3 group C member 1	Homo sapiens	140-142
15145929-2	2004	However, the laboratory that discovered pifithrin recently reported that the compound also inhibits heat shock and glucocorticoid receptor (GR) signaling, and they suggested that PFTalpha targets a factor common to all three signal transduction pathways, such as the hsp90/hsp70-based chaperone machinery (Komarova, E. A., Neznanov, N., Komarov, P. G., Chernov, M. V., Wang, K., and Gudkov, A. V. (2003) J. Biol.	pifithrin	40-49	heat shock protein 90 alpha family class A member 1	Homo sapiens	267-272
15145929-2	2004	However, the laboratory that discovered pifithrin recently reported that the compound also inhibits heat shock and glucocorticoid receptor (GR) signaling, and they suggested that PFTalpha targets a factor common to all three signal transduction pathways, such as the hsp90/hsp70-based chaperone machinery (Komarova, E. A., Neznanov, N., Komarov, P. G., Chernov, M. V., Wang, K., and Gudkov, A. V. (2003) J. Biol.	pifithrin	179-187	heat shock protein 90 alpha family class A member 1	Homo sapiens	267-272
15145929-2	2004	However, the laboratory that discovered pifithrin recently reported that the compound also inhibits heat shock and glucocorticoid receptor (GR) signaling, and they suggested that PFTalpha targets a factor common to all three signal transduction pathways, such as the hsp90/hsp70-based chaperone machinery (Komarova, E. A., Neznanov, N., Komarov, P. G., Chernov, M. V., Wang, K., and Gudkov, A. V. (2003) J. Biol.	pifithrin	179-187	heat shock protein family A (Hsp70) member 4	Homo sapiens	273-278
15252149-10	2004	Attenuating p53 by a chemical inhibitor pifithrin-alpha decreased the selenite-induced p53 Ser15P and led to concordant reductions of PARP cleavage and apoptosis.	pifithrin	40-49	tumor protein p53	Homo sapiens	87-90
15252149-10	2004	Attenuating p53 by a chemical inhibitor pifithrin-alpha decreased the selenite-induced p53 Ser15P and led to concordant reductions of PARP cleavage and apoptosis.	pifithrin	40-49	poly(ADP-ribose) polymerase 1	Homo sapiens	134-138
15054096-8	2004	Further evidence was obtained using a p53 inhibitor, pifithrin-alpha.	pifithrin	53-68	tumor protein p53	Homo sapiens	38-41
15054096-9	2004	Pifithrin-alpha completely suppressed DOX-induced activation of p53 in both normal and tumor cell lines and prevented apoptosis in tumor cell lines but not in endothelial cells and cardiomyocytes.	pifithrin	0-15	tumor protein p53	Homo sapiens	64-67
12893085-0	2003	Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells.	pifithrin	34-49	tumor protein p53	Homo sapiens	14-17
15144874-0	2004	The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.	pifithrin	85-100	tumor protein p53	Homo sapiens	71-74
15144874-4	2004	Pifithrin alpha reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its DNA sites as it reduced the expression of the p53-related gene p21(WAF) without changing the amount of p53 protein itself.	pifithrin	0-15	tumor protein p53	Homo sapiens	105-108
15144874-4	2004	Pifithrin alpha reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its DNA sites as it reduced the expression of the p53-related gene p21(WAF) without changing the amount of p53 protein itself.	pifithrin	0-15	tumor protein p53	Homo sapiens	162-165
15144874-4	2004	Pifithrin alpha reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its DNA sites as it reduced the expression of the p53-related gene p21(WAF) without changing the amount of p53 protein itself.	pifithrin	0-15	H3 histone pseudogene 16	Homo sapiens	179-182
15144874-4	2004	Pifithrin alpha reduced the number of apoptotic cells in the ischemic brain by inhibiting the binding of p53 to its DNA sites as it reduced the expression of the p53-related gene p21(WAF) without changing the amount of p53 protein itself.	pifithrin	0-15	tumor protein p53	Homo sapiens	162-165
15050415-9	2004	Apoptosis was blocked by pifithrin-alpha, the chemical inhibitor of p53.	pifithrin	25-40	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	68-71
15001399-6	2004	In contrast, in MCF-7 cells with wild type p53 and estrogen receptor, there was no change in Akt activation, while suppression of p53 activity by pifithrin-alpha increased phosphorylation of Akt after the treatment with copper.	pifithrin	146-155	tumor protein p53	Homo sapiens	130-133
15001399-6	2004	In contrast, in MCF-7 cells with wild type p53 and estrogen receptor, there was no change in Akt activation, while suppression of p53 activity by pifithrin-alpha increased phosphorylation of Akt after the treatment with copper.	pifithrin	146-155	AKT serine/threonine kinase 1	Homo sapiens	191-194
14993250-6	2004	Microarrays revealed that most (85%) of the transcriptional effects of HIV-1 Env were blocked by the p53 inhibitor pifithrin-alpha.	pifithrin	115-130	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	77-80
14993250-6	2004	Microarrays revealed that most (85%) of the transcriptional effects of HIV-1 Env were blocked by the p53 inhibitor pifithrin-alpha.	pifithrin	115-130	tumor protein p53	Homo sapiens	101-104
14644432-5	2003	Furthermore, pifithrin alpha (a p53 inhibitor), administered to isolated perfused hearts prior to ischaemia, significantly attenuated the infarction.	pifithrin	13-28	transformation related protein 53, pseudogene	Mus musculus	32-35
12967348-0	2003	The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro.	pifithrin	18-33	tumor protein p53	Homo sapiens	4-7
12967348-2	2003	It has been proposed that the use of pifithrin-alpha in conjunction with chemotherapeutic and radiation therapies for cancer will reduce the side effects of these treatments in normal tissue that still contains wild type p53.	pifithrin	37-46	tumor protein p53	Homo sapiens	221-224
12967348-3	2003	In addition, pifithrin-alpha provides a useful tool in the laboratory to investigate the function of p53 in model systems.	pifithrin	13-22	tumor protein p53	Homo sapiens	101-104
12893085-0	2003	Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells.	pifithrin	34-49	BCL2 associated X, apoptosis regulator	Homo sapiens	27-30
12637507-1	2003	Pifithrin alpha (PFTalpha) is a chemical compound isolated for its ability to suppress p53-mediated transactivation.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	87-90
12884365-6	2003	Thus, we conclude that PFTalpha is not a specific p53 inhibitor in JB6 cells but is a potential activator of p53-mediated signaling and apoptosis.	pifithrin	23-31	tumor protein p53	Homo sapiens	109-112
12884365-1	2003	Recently, blockage of p53-dependent transcriptional activation and apoptosis by pifithrin-alpha (PFTalpha) has been reported to be useful for reducing the side effects of cancer therapy and the compound is thus thought to be a specific inhibitor of p53 [Komarov et al., Science 1999;285:1733-1737].	pifithrin	80-95	tumor protein p53	Homo sapiens	22-25
12884365-1	2003	Recently, blockage of p53-dependent transcriptional activation and apoptosis by pifithrin-alpha (PFTalpha) has been reported to be useful for reducing the side effects of cancer therapy and the compound is thus thought to be a specific inhibitor of p53 [Komarov et al., Science 1999;285:1733-1737].	pifithrin	80-95	tumor protein p53	Homo sapiens	249-252
12884365-1	2003	Recently, blockage of p53-dependent transcriptional activation and apoptosis by pifithrin-alpha (PFTalpha) has been reported to be useful for reducing the side effects of cancer therapy and the compound is thus thought to be a specific inhibitor of p53 [Komarov et al., Science 1999;285:1733-1737].	pifithrin	97-105	tumor protein p53	Homo sapiens	22-25
12884365-1	2003	Recently, blockage of p53-dependent transcriptional activation and apoptosis by pifithrin-alpha (PFTalpha) has been reported to be useful for reducing the side effects of cancer therapy and the compound is thus thought to be a specific inhibitor of p53 [Komarov et al., Science 1999;285:1733-1737].	pifithrin	97-105	tumor protein p53	Homo sapiens	249-252
12884365-3	2003	Instead, p53-dependent activation and apoptosis were not only induced by PFTalpha itself but were also enhanced by a combination of PFTalpha with UVB or Dox.	pifithrin	73-81	tumor protein p53	Homo sapiens	9-12
12884365-4	2003	Furthermore, PFTalpha-induced apoptosis was mediated through p53-dependent and -independent signaling pathways.	pifithrin	13-21	tumor protein p53	Homo sapiens	61-64
12884365-5	2003	Extracellular signal-regulated kinases and p38 kinase, but not c-jun N-terminal kinases (JNKs), were activated, and these activations were required for phosphorylation and accumulation of p53 in the cellular apoptotic response to PFTalpha.	pifithrin	230-238	tumor protein p53	Homo sapiens	188-191
12637507-1	2003	Pifithrin alpha (PFTalpha) is a chemical compound isolated for its ability to suppress p53-mediated transactivation.	pifithrin	17-25	transformation related protein 53, pseudogene	Mus musculus	87-90
12637507-5	2003	PFTalpha reduces activation of heat shock transcription factor (HSF1) and increases cell sensitivity to heat.	pifithrin	0-8	heat shock factor 1	Mus musculus	64-68
12786980-5	2003	In order to test the role of p53 in the central nervous system, we injected a pharmacological inhibitor of p53 activation, pifithrin-alpha, into the cerebellum of wild-type mice.	pifithrin	123-138	transformation related protein 53, pseudogene	Mus musculus	107-110
12408720-2	2002	Recent studies identified the tetrahydrobenzothiazole analogue, pifithrin-alpha (2), as a p53 inhibitor that was effective in protecting neuronal cells against a variety of lethal insults and reducing the side effects of anticancer drugs.	pifithrin	64-79	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	90-93
12556443-8	2003	Interestingly, CTF-PS2-induced caspase 3 activation is prevented by pifithrin-alpha, a selective blocker of p53 transcriptional activity.	pifithrin	68-77	caspase 3	Homo sapiens	31-40
12556443-8	2003	Interestingly, CTF-PS2-induced caspase 3 activation is prevented by pifithrin-alpha, a selective blocker of p53 transcriptional activity.	pifithrin	68-77	tumor protein p53	Homo sapiens	108-111
12660163-5	2003	Induction of ICAM-1 is abolished after treatment with the specific p53 inhibitor pifithrin-alpha and is abrogated in p53-deficient cell lines.	pifithrin	81-96	intercellular adhesion molecule 1	Homo sapiens	13-19
12660163-5	2003	Induction of ICAM-1 is abolished after treatment with the specific p53 inhibitor pifithrin-alpha and is abrogated in p53-deficient cell lines.	pifithrin	81-96	tumor protein p53	Homo sapiens	67-70
12506145-8	2003	Pifithrin-alpha, a specific inhibitor of p53, mimicked the effects of guanosine.	pifithrin	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	41-44
12849752-7	2003	Addition of PFT (20-100 microM) to cisplatin-treated cochlear and utricular cultures resulted in a dose-dependent increase in hair cell survival; suppressed the expression of p53 in Western blots and eliminated caspase-1 and caspase-3 labeling in cultures.	pifithrin	12-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	175-178
12849752-7	2003	Addition of PFT (20-100 microM) to cisplatin-treated cochlear and utricular cultures resulted in a dose-dependent increase in hair cell survival; suppressed the expression of p53 in Western blots and eliminated caspase-1 and caspase-3 labeling in cultures.	pifithrin	12-15	caspase 1	Rattus norvegicus	211-220
12849752-7	2003	Addition of PFT (20-100 microM) to cisplatin-treated cochlear and utricular cultures resulted in a dose-dependent increase in hair cell survival; suppressed the expression of p53 in Western blots and eliminated caspase-1 and caspase-3 labeling in cultures.	pifithrin	12-15	caspase 3	Rattus norvegicus	225-234
12702593-6	2003	In contrast, when the legs of p53 null animals or wild-type p53 mice treated with pifithrin-alpha (a p53 blocker) were irradiated (five 10-Gy fractions), tumor growth was not delayed.	pifithrin	82-97	transformation related protein 53	Mus musculus	60-63
12702593-6	2003	In contrast, when the legs of p53 null animals or wild-type p53 mice treated with pifithrin-alpha (a p53 blocker) were irradiated (five 10-Gy fractions), tumor growth was not delayed.	pifithrin	82-97	transformation related protein 53	Mus musculus	60-63
12509264-1	2003	We investigated the effect of pifithrin-alpha (PFTalpha), a chemical inhibitor of p53, on DNA double-strand break (DSB) repair in mammalian chromosomes.	pifithrin	30-45	tumor protein p53	Homo sapiens	82-85
12509264-1	2003	We investigated the effect of pifithrin-alpha (PFTalpha), a chemical inhibitor of p53, on DNA double-strand break (DSB) repair in mammalian chromosomes.	pifithrin	47-55	tumor protein p53	Homo sapiens	82-85
12151395-5	2002	Moreover, the role of p53 in activation of this pathway was demonstrated by the fact that inhibition of p53 activity by pifithrin-alpha reduced the sensitivity of HCT116/p21(-/-) cells to daunomycin-induced apoptosis and restored a Bax/Bcl-2 ratio similar to that observed in HCT116p21(+/+) cells.	pifithrin	120-135	tumor protein p53	Homo sapiens	104-107
12413886-8	2002	P21 mRNA was increased to detectable levels in M12 cells upon CD40 ligation; however, blocking this effect with the p53 inhibitor pifithrin had no effect on CD40-mediated apoptosis.	pifithrin	130-139	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	0-3
12413886-8	2002	P21 mRNA was increased to detectable levels in M12 cells upon CD40 ligation; however, blocking this effect with the p53 inhibitor pifithrin had no effect on CD40-mediated apoptosis.	pifithrin	130-139	transformation related protein 53, pseudogene	Mus musculus	116-119
12151395-5	2002	Moreover, the role of p53 in activation of this pathway was demonstrated by the fact that inhibition of p53 activity by pifithrin-alpha reduced the sensitivity of HCT116/p21(-/-) cells to daunomycin-induced apoptosis and restored a Bax/Bcl-2 ratio similar to that observed in HCT116p21(+/+) cells.	pifithrin	120-135	cyclin dependent kinase inhibitor 1A	Homo sapiens	170-173
12151395-5	2002	Moreover, the role of p53 in activation of this pathway was demonstrated by the fact that inhibition of p53 activity by pifithrin-alpha reduced the sensitivity of HCT116/p21(-/-) cells to daunomycin-induced apoptosis and restored a Bax/Bcl-2 ratio similar to that observed in HCT116p21(+/+) cells.	pifithrin	120-135	tumor protein p53	Homo sapiens	22-25
12151395-5	2002	Moreover, the role of p53 in activation of this pathway was demonstrated by the fact that inhibition of p53 activity by pifithrin-alpha reduced the sensitivity of HCT116/p21(-/-) cells to daunomycin-induced apoptosis and restored a Bax/Bcl-2 ratio similar to that observed in HCT116p21(+/+) cells.	pifithrin	120-135	BCL2 associated X, apoptosis regulator	Homo sapiens	232-235
12151395-5	2002	Moreover, the role of p53 in activation of this pathway was demonstrated by the fact that inhibition of p53 activity by pifithrin-alpha reduced the sensitivity of HCT116/p21(-/-) cells to daunomycin-induced apoptosis and restored a Bax/Bcl-2 ratio similar to that observed in HCT116p21(+/+) cells.	pifithrin	120-135	BCL2 apoptosis regulator	Homo sapiens	236-241
11827710-0	2002	Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro.	pifithrin	0-15	tumor protein p53	Homo sapiens	33-36
12131363-13	2002	Pifithrin-alpha (Calbiochem), a p53 inhibitor, blocked resveratrol induced serine-15 phosphorylation of p53 and p53 binding to DNA.	pifithrin	0-15	tumor protein p53	Homo sapiens	32-35
12131363-13	2002	Pifithrin-alpha (Calbiochem), a p53 inhibitor, blocked resveratrol induced serine-15 phosphorylation of p53 and p53 binding to DNA.	pifithrin	0-15	tumor protein p53	Homo sapiens	104-107
12131363-13	2002	Pifithrin-alpha (Calbiochem), a p53 inhibitor, blocked resveratrol induced serine-15 phosphorylation of p53 and p53 binding to DNA.	pifithrin	0-15	tumor protein p53	Homo sapiens	104-107
11904448-6	2002	We also establish that wild-type- and mutated PS2-induced caspase activation is reduced by p53 antisense approach and by pifithrin-alpha, a chemical inhibitor of p53.	pifithrin	121-136	presenilin 2	Homo sapiens	46-49
11904448-6	2002	We also establish that wild-type- and mutated PS2-induced caspase activation is reduced by p53 antisense approach and by pifithrin-alpha, a chemical inhibitor of p53.	pifithrin	121-136	tumor protein p53	Homo sapiens	162-165
11889192-4	2002	Addition of pifithrin-alpha, a specific inhibitor of p53, or transfection of p53 antisense oligonucleotides caused decreased RV-induced p53 and p21 expression in PTC and FTC cells.	pifithrin	12-27	tumor protein p53	Homo sapiens	53-56
11889192-4	2002	Addition of pifithrin-alpha, a specific inhibitor of p53, or transfection of p53 antisense oligonucleotides caused decreased RV-induced p53 and p21 expression in PTC and FTC cells.	pifithrin	12-27	H3 histone pseudogene 16	Homo sapiens	144-147
11279278-2	2001	Based upon recent studies characterizing chemical inhibitors of p53 in preclinical studies in the cancer therapy field, we synthesized the compound pifithrin-alpha and evaluated its potential neuroprotective properties in experimental models relevant to the pathogenesis of stroke and neurodegenerative disorders.	pifithrin	148-163	tumor protein p53	Homo sapiens	64-67
11792826-4	2001	To further test this hypothesis, we investigated the effects of cycloheximide and pifithrin-alpha, which inhibits p53-dependent transcriptional activation, on nuclear transport.	pifithrin	82-97	transformation related protein 53, pseudogene	Mus musculus	114-117
11792826-10	2001	Pifithrin-alpha also caused an increase in functional pore diameter without altering the import rate of FITC-BSA-NLS, providing further support for the view that p53 can initiate changes in nuclear transport capacity.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	162-165
11931974-9	2002	Addition of pifithrin-alpha (PFT), a specific inhibitor of p53, reduced the activation of p53 with a concomitant decrease in growth arrest at S phase.	pifithrin	12-27	tumor protein p53	Homo sapiens	59-62
33031904-8	2020	However, pretreatment with the ROS scavenger N-acetyl-L-cysteine (NAC) or the p53 transcription specific inhibitor PFT-alpha suppressed Cd-induced apoptosis.	pifithrin	115-124	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	78-81
11931974-9	2002	Addition of pifithrin-alpha (PFT), a specific inhibitor of p53, reduced the activation of p53 with a concomitant decrease in growth arrest at S phase.	pifithrin	12-27	tumor protein p53	Homo sapiens	90-93
34518457-12	2022	Besides, the XCL1 overexpression-induced downregulation of NF-kappaB was reversed by pifithrin-alpha pretreatment.	pifithrin	85-100	X-C motif chemokine ligand 1	Homo sapiens	13-17
34518457-12	2022	Besides, the XCL1 overexpression-induced downregulation of NF-kappaB was reversed by pifithrin-alpha pretreatment.	pifithrin	85-100	nuclear factor kappa B subunit 1	Homo sapiens	59-68
34959709-8	2021	Moreover, treatment with the p53 inhibitor pifithrin-alpha (PFT-alpha) inhibited autophagy and increased apoptotic response in MLPE-treated HepG2 cells.	pifithrin	43-58	tumor protein p53	Homo sapiens	29-32
34945706-4	2021	MDA-MB-231 (p53-p.R280K mutant) and MCF-7 (wild-type p53) breast tumor cells and MCF-10A non-tumoral cells were exposed to GTE for 24-48 h and cell viability was assessed in the presence of p53 inhibitor pifithrin-alpha.	pifithrin	204-219	tumor protein p53	Homo sapiens	190-193
34959709-8	2021	Moreover, treatment with the p53 inhibitor pifithrin-alpha (PFT-alpha) inhibited autophagy and increased apoptotic response in MLPE-treated HepG2 cells.	pifithrin	60-69	tumor protein p53	Homo sapiens	29-32
34959709-9	2021	PFT-alpha treatment also reversed MLPE-induced PI3K, p-AKT, and FASN suppression.	pifithrin	0-9	AKT serine/threonine kinase 1	Homo sapiens	55-58
34959709-9	2021	PFT-alpha treatment also reversed MLPE-induced PI3K, p-AKT, and FASN suppression.	pifithrin	0-9	fatty acid synthase	Homo sapiens	64-68
34959709-10	2021	Thus, co-treatment with MLPE and PFT-alpha significantly increased caspase-3, caspase-8, and cytochrome c release, indicating that p53 deficiency caused the apoptosis.	pifithrin	33-42	caspase 3	Homo sapiens	67-76
34959709-10	2021	Thus, co-treatment with MLPE and PFT-alpha significantly increased caspase-3, caspase-8, and cytochrome c release, indicating that p53 deficiency caused the apoptosis.	pifithrin	33-42	caspase 8	Homo sapiens	78-87
34959709-10	2021	Thus, co-treatment with MLPE and PFT-alpha significantly increased caspase-3, caspase-8, and cytochrome c release, indicating that p53 deficiency caused the apoptosis.	pifithrin	33-42	cytochrome c, somatic	Homo sapiens	93-105
34959709-10	2021	Thus, co-treatment with MLPE and PFT-alpha significantly increased caspase-3, caspase-8, and cytochrome c release, indicating that p53 deficiency caused the apoptosis.	pifithrin	33-42	tumor protein p53	Homo sapiens	131-134
34635886-3	2021	Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core-shell nanoparticles and then loaded Pifithrin-mu (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage.	pifithrin	142-151	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	185-203
34845969-7	2021	Finally, cisatracurium besilate and pifithrin-alpha were used to co-treat TRAIL-induced AGS cells followed by apoptosis detection.	pifithrin	36-51	TNF superfamily member 10	Homo sapiens	74-79
34845969-11	2021	However, pifithrin-alpha reversed the synergistic effects of cisatracurium besilate and TRAIL on the activities of AGS cells.	pifithrin	9-24	TNF superfamily member 10	Homo sapiens	88-93
34864826-8	2021	After silencing p53 or using the p53 inhibitor PFTalpha, the autophagy induced by CC90003 was weakened and the rate of cell death increases.	pifithrin	47-55	transformation related protein 53, pseudogene	Mus musculus	33-36
34635886-3	2021	Herein, we developed zeolite-based imidazole framework (ZIF-8)-coated mesoporous polydopamine (MPDA) core-shell nanoparticles and then loaded Pifithrin-mu (PES), a natural inhibitor of heat-shock protein (HSP) that plays an essential role in bacteria resisting heating-induced damage.	pifithrin	142-151	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	205-208
34119535-27	2021	Autophagy-related proteins LC-3, Beclin-1, and DRAM were inhibited by P53 inhibitor Pifithrin-alpha (PFTalpha) (P < 0.05).	pifithrin	84-99	beclin 1	Macaca mulatta	33-41
34977486-4	2021	Methods: Mice in the Pifithrin-alpha group were injected intraperitoneally with 2.5 mg/kg Pifithrin-alpha (TAp73 inhibitor) daily for 30 consecutive days.	pifithrin	90-105	transformation related protein 73	Mus musculus	107-112
34119535-27	2021	Autophagy-related proteins LC-3, Beclin-1, and DRAM were inhibited by P53 inhibitor Pifithrin-alpha (PFTalpha) (P < 0.05).	pifithrin	84-99	DNA damage regulated autophagy modulator 1	Macaca mulatta	47-51
34119535-27	2021	Autophagy-related proteins LC-3, Beclin-1, and DRAM were inhibited by P53 inhibitor Pifithrin-alpha (PFTalpha) (P < 0.05).	pifithrin	101-109	beclin 1	Macaca mulatta	33-41
34746182-5	2021	Pifithrin-alpha, a pharmacologic p53 inhibitor, could reduce acute tubular injury, apoptosis and inflammation at 24 h after cold storage/transplantation.	pifithrin	0-15	transformation related protein 53, pseudogene	Mus musculus	33-36
34119535-27	2021	Autophagy-related proteins LC-3, Beclin-1, and DRAM were inhibited by P53 inhibitor Pifithrin-alpha (PFTalpha) (P < 0.05).	pifithrin	101-109	DNA damage regulated autophagy modulator 1	Macaca mulatta	47-51
35349858-6	2022	The addition of p53 inhibitor pifithrin-alpha (10 muM) exerted protection against of THCP-induced hepatotoxicity by reducing oxidative stress and inhibiting the p53 signaling pathway and apoptosis.	pifithrin	30-45	tumor protein p53	Danio rerio	16-19
34469060-12	2021	Inhibition of p53 by PFT-alpha partially restored the levels of PD-L1 and miR-34a-5p.	pifithrin	21-30	tumor protein p53	Homo sapiens	14-17
34469060-12	2021	Inhibition of p53 by PFT-alpha partially restored the levels of PD-L1 and miR-34a-5p.	pifithrin	21-30	CD274 molecule	Homo sapiens	64-69
34311053-9	2021	More importantly, the p53 inhibitor pifithrin-alpha could significantly block cortical SAH-induced ferroptosis.	pifithrin	36-51	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	22-25
34427098-9	2021	Furthermore, CDKL3 knockdown increases p53 expression and reduces cell viability, and these effects are significantly weakened by the p53 inhibitor, PFT-alpha.	pifithrin	149-158	cyclin dependent kinase like 3	Homo sapiens	13-18
34427098-9	2021	Furthermore, CDKL3 knockdown increases p53 expression and reduces cell viability, and these effects are significantly weakened by the p53 inhibitor, PFT-alpha.	pifithrin	149-158	tumor protein p53	Homo sapiens	39-42
34427098-9	2021	Furthermore, CDKL3 knockdown increases p53 expression and reduces cell viability, and these effects are significantly weakened by the p53 inhibitor, PFT-alpha.	pifithrin	149-158	tumor protein p53	Homo sapiens	134-137
34091999-0	2021	P53 inhibitor pifithrin-alpha inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.	pifithrin	14-29	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
34091999-8	2021	The results of immunofluorescence and immunohistochemistry testing showed that PFT-alpha inhibited the p53 protein upregulated by Rop.	pifithrin	79-88	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	103-106
34091999-9	2021	Apoptosis rate and many proapoptotic genes include p53, Bax, caspase-3 messenger RNA, and proteins were increased by Rop, but PFT-alpha could decrease it.	pifithrin	126-135	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	51-54
34091999-9	2021	Apoptosis rate and many proapoptotic genes include p53, Bax, caspase-3 messenger RNA, and proteins were increased by Rop, but PFT-alpha could decrease it.	pifithrin	126-135	BCL2 associated X, apoptosis regulator	Rattus norvegicus	56-59
34091999-9	2021	Apoptosis rate and many proapoptotic genes include p53, Bax, caspase-3 messenger RNA, and proteins were increased by Rop, but PFT-alpha could decrease it.	pifithrin	126-135	caspase 3	Rattus norvegicus	61-70
34285767-10	2021	Importantly, PIN1 expression was significantly increased by treatment with the p53 inhibitor pifithrin-alpha.	pifithrin	93-108	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	13-17
34285767-10	2021	Importantly, PIN1 expression was significantly increased by treatment with the p53 inhibitor pifithrin-alpha.	pifithrin	93-108	transformation related protein 53, pseudogene	Mus musculus	79-82
34340236-11	2021	When the p53 inhibitor PFT-alpha was injected, the increase in these levels was reversed.	pifithrin	23-32	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	9-12
35143901-7	2022	The p53 inhibitor pifithrin-alpha partially restored the production of polyamines, but the mitochondrial morphology and function were still impaired.	pifithrin	18-33	transformation related protein 53, pseudogene	Mus musculus	4-7
34707773-7	2021	More importantly, STAT3 overexpression, SLC7A11 overexpression, and pretreatment with pifithrin-alpha (P53 inhibitor) rescued OS cell ferroptosis induced by bavachin.	pifithrin	86-101	tumor protein p53	Homo sapiens	103-106
34488389-11	2021	However, the expression of Bcl-2 increased when HC-030031, pifithrin-alpha, or FK506 was used alone, and HC-030031 combined with pifithrin-alpha or FK506 further improved the expression of Bcl-2.	pifithrin	59-68	BCL2 apoptosis regulator	Homo sapiens	27-32
34488389-11	2021	However, the expression of Bcl-2 increased when HC-030031, pifithrin-alpha, or FK506 was used alone, and HC-030031 combined with pifithrin-alpha or FK506 further improved the expression of Bcl-2.	pifithrin	59-68	BCL2 apoptosis regulator	Homo sapiens	189-194
34202551-9	2021	Treatment Vero cells with the p53 inhibitor, PFT-alpha, could significantly inhibit PEDV-induced apoptosis.	pifithrin	45-54	tumor protein p53	Homo sapiens	30-33
35349858-6	2022	The addition of p53 inhibitor pifithrin-alpha (10 muM) exerted protection against of THCP-induced hepatotoxicity by reducing oxidative stress and inhibiting the p53 signaling pathway and apoptosis.	pifithrin	30-45	tumor protein p53	Danio rerio	161-164
35530319-10	2022	Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5.	pifithrin	103-112	tumor protein p53	Homo sapiens	13-16
35530319-10	2022	Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5.	pifithrin	103-112	tumor protein p53	Homo sapiens	34-37
35337799-7	2022	The results show that P53 mediates the dissociation induced-ferroptosis in hESCs which is suppressed by Pifithrin alpha.	pifithrin	104-119	tumor protein p53	Homo sapiens	22-25
35418568-7	2022	The p53 inhibitor pifithrin-alpha significantly attenuated SGN and HC damage and rescued hearing impairment in Rest cKO mice.	pifithrin	18-33	transformation related protein 53, pseudogene	Mus musculus	4-7
35530319-10	2022	Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5.	pifithrin	103-112	alkB homolog 5, RNA demethylase	Homo sapiens	137-143
35530319-10	2022	Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5.	pifithrin	103-112	tumor protein p53	Homo sapiens	248-251
35530319-10	2022	Knockdown of p53 or inhibition of p53"s transcriptional activity by addition of its specific inhibitor PFT-alpha decreased expression of ALKBH5 and CSCs" malignancies, including proliferation, invasion, and tumor formation ability, indicating that p53 may partially regulate CSC"s malignancies via ALKBH5.	pifithrin	103-112	alkB homolog 5, RNA demethylase	Homo sapiens	298-304
35418961-9	2022	The treatment of PFT-alpha (p53 inhibitor) significantly suppressed the expression of cleaved caspase 9 and caspase 3, leading to the decrease of apoptosis.	pifithrin	17-26	tumor protein p53	Homo sapiens	28-31
35418961-9	2022	The treatment of PFT-alpha (p53 inhibitor) significantly suppressed the expression of cleaved caspase 9 and caspase 3, leading to the decrease of apoptosis.	pifithrin	17-26	caspase 9	Homo sapiens	94-103
35418961-9	2022	The treatment of PFT-alpha (p53 inhibitor) significantly suppressed the expression of cleaved caspase 9 and caspase 3, leading to the decrease of apoptosis.	pifithrin	17-26	caspase 3	Homo sapiens	108-117
35356282-5	2022	In some experiments, cells were pre-treated with rapamycin (an activator of autophagy), 3-MA (an inhibitor of autophagy), or cyclic pifithrin-alpha (PFT-alpha, an antagonist of p53), and then treated with AOPPs.	pifithrin	149-158	tumor protein p53	Homo sapiens	177-180
35103478-11	2022	Notably, P53 activation with Nutilin3 significantly weakened the epithelial-mesenchymal transformation (EMT) promotion effect of ASF1B, while P53 inhibition with pifithrin-alpha significantly enhanced the EMT promotion effect of sh-ASF1B.	pifithrin	162-177	tumor protein p53	Homo sapiens	142-145
35356282-14	2022	Pre-treatment with rapamycin or PFT-alpha significantly down-regulated the levels of SA beta-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated DeltaPsim, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs.	pifithrin	32-41	serum amyloid A1 cluster	Homo sapiens	85-92
35356282-14	2022	Pre-treatment with rapamycin or PFT-alpha significantly down-regulated the levels of SA beta-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated DeltaPsim, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs.	pifithrin	32-41	tumor protein p53	Homo sapiens	106-109
35356282-14	2022	Pre-treatment with rapamycin or PFT-alpha significantly down-regulated the levels of SA beta-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated DeltaPsim, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs.	pifithrin	32-41	H3 histone pseudogene 16	Homo sapiens	111-114
35356282-14	2022	Pre-treatment with rapamycin or PFT-alpha significantly down-regulated the levels of SA beta-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated DeltaPsim, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs.	pifithrin	32-41	nucleoporin 62	Homo sapiens	142-145
35356282-14	2022	Pre-treatment with rapamycin or PFT-alpha significantly down-regulated the levels of SA beta-Gal, SAHF, p-p53, p21, autophagy related protein p62, the percentage of cells in the G0/G1 phase, and significantly up-regulated DeltaPsim, autophagy related protein BECN1, autophagosomes and autolysosomes compared with cells only treated with AOPPs.	pifithrin	32-41	beclin 1	Homo sapiens	259-264
35103478-11	2022	Notably, P53 activation with Nutilin3 significantly weakened the epithelial-mesenchymal transformation (EMT) promotion effect of ASF1B, while P53 inhibition with pifithrin-alpha significantly enhanced the EMT promotion effect of sh-ASF1B.	pifithrin	162-177	anti-silencing function 1B histone chaperone	Homo sapiens	232-237
35203361-4	2022	In mouse proximal tubular BUMPT cells, RLDC treatment induced p53 activation, apoptosis, and fibrotic changes, which were suppressed by pifithrin-alpha, a pharmacologic inhibitor of p53.	pifithrin	136-151	transformation related protein 53, pseudogene	Mus musculus	62-65
35203361-4	2022	In mouse proximal tubular BUMPT cells, RLDC treatment induced p53 activation, apoptosis, and fibrotic changes, which were suppressed by pifithrin-alpha, a pharmacologic inhibitor of p53.	pifithrin	136-151	transformation related protein 53, pseudogene	Mus musculus	182-185
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	pifithrin	75-90	tumor protein p53	Homo sapiens	52-55
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	pifithrin	75-90	tumor protein p53	Homo sapiens	192-195
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	pifithrin	92-101	tumor protein p53	Homo sapiens	52-55
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	pifithrin	92-101	tumor protein p53	Homo sapiens	192-195