PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32329078-8 2020 Blocking either IL-12 or IFNgamma in Tnfaip3Lg-KO mice restored Th2-responses, whereas administration of recombinant IFNgamma during HDM sensitization in C57Bl/6 mice blocked Th2-development. th2 64-67 interferon gamma Mus musculus 25-33 32563138-5 2020 IL-33 is an alarmin which increases innate immunity through Th2 responses. th2 60-63 interleukin 33 Mus musculus 0-5 32383224-6 2020 This increase in RV-induced Th2 development was regulated by IgE-mediated inhibition of virus-induced type I IFN and induction of IL-10. th2 28-31 interleukin 10 Homo sapiens 130-135 32848032-6 2020 In contrast, in Th2-polarized settings such as house dust mite-induced allergic airway inflammation, the lack of IRF4 expression in the DC compartment alleviates inflammation and goblet cell metaplasia. th2 16-19 interferon regulatory factor 4 Mus musculus 113-117 33072069-0 2020 Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages. th2 67-70 peroxiredoxin 1 Mus musculus 21-45 33072069-10 2020 Moreover, MrTsTPX2 could promote CD4+ T cells polarized into Th2 type in vitro. th2 61-64 CD4 antigen Mus musculus 33-36 32971928-0 2020 Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner. th2 36-39 semaphorin 4A Homo sapiens 0-12 32971928-0 2020 Semaphorin4A-Plexin D1 Axis Induces Th2 and Th17 While Represses Th1 Skewing in an Autocrine Manner. th2 36-39 plexin D1 Homo sapiens 13-22 32954441-1 2021 Periostin, an extracelluar matrix protein belonging to the fasciclin family, has been reported to play a key role in the process of Th2-inflammation disease. th2 132-135 periostin Homo sapiens 0-9 32956405-11 2020 In summary, our results point strongly towards the cell-specific and contextual function of Nlrx1 during invasive pulmonary aspergillosis and may lead to novel therapeutics to reduce Th2 responses by CD103+ DCs or heightened recruitment of neutrophils. th2 183-186 NLR family member X1 Homo sapiens 92-97 33042121-6 2020 Here we report and discuss the Th2-dependent and Th2-independent roles of TSLP in cancer and possible therapeutic targeting. th2 31-34 thymic stromal lymphopoietin Homo sapiens 74-78 33042121-6 2020 Here we report and discuss the Th2-dependent and Th2-independent roles of TSLP in cancer and possible therapeutic targeting. th2 49-52 thymic stromal lymphopoietin Homo sapiens 74-78 32921633-7 2020 Tc1 and Tc2 secreted IFN-gamma, contributing to the decrease in the Th2-induced over-polarization of M2 macrophages and fibrosis. th2 68-71 transcobalamin 2 Mus musculus 8-11 32921633-7 2020 Tc1 and Tc2 secreted IFN-gamma, contributing to the decrease in the Th2-induced over-polarization of M2 macrophages and fibrosis. th2 68-71 interferon gamma Mus musculus 21-30 32839313-6 2020 Fever sensing by CD4 T cells involved transient receptor potential vanilloid cation channels (TRPVs) since TRPV1/TRPV4 antagonism blocked the febrile Th2 switch, while TRPV1 agonists mediated a Th2 switch at 37 C. The febrile Th2 switch was IL4 independent, but a gamma-secretase inhibitor abrogated it, and it was not found in Notch1-null CD4 T cells, identifying the Notch pathway as a major mediator. th2 150-153 CD4 molecule Homo sapiens 17-20 32839313-6 2020 Fever sensing by CD4 T cells involved transient receptor potential vanilloid cation channels (TRPVs) since TRPV1/TRPV4 antagonism blocked the febrile Th2 switch, while TRPV1 agonists mediated a Th2 switch at 37 C. The febrile Th2 switch was IL4 independent, but a gamma-secretase inhibitor abrogated it, and it was not found in Notch1-null CD4 T cells, identifying the Notch pathway as a major mediator. th2 150-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 32839313-6 2020 Fever sensing by CD4 T cells involved transient receptor potential vanilloid cation channels (TRPVs) since TRPV1/TRPV4 antagonism blocked the febrile Th2 switch, while TRPV1 agonists mediated a Th2 switch at 37 C. The febrile Th2 switch was IL4 independent, but a gamma-secretase inhibitor abrogated it, and it was not found in Notch1-null CD4 T cells, identifying the Notch pathway as a major mediator. th2 150-153 transient receptor potential cation channel subfamily V member 4 Homo sapiens 113-118 32839313-6 2020 Fever sensing by CD4 T cells involved transient receptor potential vanilloid cation channels (TRPVs) since TRPV1/TRPV4 antagonism blocked the febrile Th2 switch, while TRPV1 agonists mediated a Th2 switch at 37 C. The febrile Th2 switch was IL4 independent, but a gamma-secretase inhibitor abrogated it, and it was not found in Notch1-null CD4 T cells, identifying the Notch pathway as a major mediator. th2 194-197 CD4 molecule Homo sapiens 17-20 32538493-10 2020 GM-Beffs generated under Th2 conditions facilitated the differentiation from CD14+ monocytes to DC-SIGN+ CD1a+ CD14- CD86+ cells, which significantly promoted the proliferation of naive T cells. th2 25-28 CD14 molecule Homo sapiens 77-81 32538493-10 2020 GM-Beffs generated under Th2 conditions facilitated the differentiation from CD14+ monocytes to DC-SIGN+ CD1a+ CD14- CD86+ cells, which significantly promoted the proliferation of naive T cells. th2 25-28 CD1a molecule Homo sapiens 105-109 32538493-10 2020 GM-Beffs generated under Th2 conditions facilitated the differentiation from CD14+ monocytes to DC-SIGN+ CD1a+ CD14- CD86+ cells, which significantly promoted the proliferation of naive T cells. th2 25-28 CD14 molecule Homo sapiens 111-115 32538493-10 2020 GM-Beffs generated under Th2 conditions facilitated the differentiation from CD14+ monocytes to DC-SIGN+ CD1a+ CD14- CD86+ cells, which significantly promoted the proliferation of naive T cells. th2 25-28 CD86 molecule Homo sapiens 117-121 32727890-0 2020 Correction: Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4+ T Cell Activities. th2 35-38 BCL2 like 12 Homo sapiens 12-19 32727890-0 2020 Correction: Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4+ T Cell Activities. th2 35-38 CD4 molecule Homo sapiens 98-101 32880064-2 2020 Therefore, development of a therapeutic approach against IL-4 signaling is expected to prevent or control Th2-related allergic diseases. th2 106-109 interleukin 4 Mus musculus 57-61 32880861-0 2021 Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells. th2 0-3 colony stimulating factor 3 (granulocyte) Mus musculus 114-151 32854770-9 2020 These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response. th2 132-135 NLR family, pyrin domain containing 3 Mus musculus 35-40 32854770-9 2020 These inductions were abolished by NLRP3 deficiency in DCs, suggesting that NLRP3 in MLES-treated DCs plays a role in promoting the Th2 and Treg response. th2 132-135 NLR family, pyrin domain containing 3 Mus musculus 76-81 32827640-14 2020 The capacity of PM10 to promote pro-inflammatory cytokines such as IL-8 and IL-23, likely to promote a Th2 profile, suggests these effects might be linked to worsening of chronic respiratory disease as these mediators are linked to asthma. th2 103-106 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 32827640-14 2020 The capacity of PM10 to promote pro-inflammatory cytokines such as IL-8 and IL-23, likely to promote a Th2 profile, suggests these effects might be linked to worsening of chronic respiratory disease as these mediators are linked to asthma. th2 103-106 interleukin 23 subunit alpha Homo sapiens 76-81 33618472-14 2020 This mouse model provides the first evidence of the capacity of DEPs to increase CD11b + Ly6C- (Th2-related) DCs. th2 96-99 integrin alpha M Mus musculus 81-86 33618472-14 2020 This mouse model provides the first evidence of the capacity of DEPs to increase CD11b + Ly6C- (Th2-related) DCs. th2 96-99 lymphocyte antigen 6 complex, locus C1 Mus musculus 89-93 32626920-12 2020 Taken together, these findings demonstrated that intranasal administration of IL-27 ameliorated Th2-related allergic lung inflammation and remodeling in mouse models of asthma by repairing both the STAT1 and STAT3 pathways. th2 96-99 interleukin 27 Mus musculus 78-83 32626920-12 2020 Taken together, these findings demonstrated that intranasal administration of IL-27 ameliorated Th2-related allergic lung inflammation and remodeling in mouse models of asthma by repairing both the STAT1 and STAT3 pathways. th2 96-99 signal transducer and activator of transcription 1 Mus musculus 198-203 32626920-12 2020 Taken together, these findings demonstrated that intranasal administration of IL-27 ameliorated Th2-related allergic lung inflammation and remodeling in mouse models of asthma by repairing both the STAT1 and STAT3 pathways. th2 96-99 signal transducer and activator of transcription 3 Mus musculus 208-213 32540689-10 2020 The sum of responses subsequent to the early IL-4 expression likely constitutes part of the unique scenario in the current BTV2-Cow experimental combination biased toward Th2 response. th2 171-174 interleukin 4 Homo sapiens 45-49 32722537-6 2020 These mapped to ~8700 gene bodies, whose genes functionally controlled organelle synthesis and Th2 pathways (IL6, TSLP). th2 95-98 interleukin 6 Homo sapiens 109-112 32722537-6 2020 These mapped to ~8700 gene bodies, whose genes functionally controlled organelle synthesis and Th2 pathways (IL6, TSLP). th2 95-98 thymic stromal lymphopoietin Homo sapiens 114-118 32710083-4 2020 Further, the serum anti-collagen antibody isotypes as well as the cytokine profiles and T cell markers in the inflamed joints revealed that CD163-deficient mice after 52 days had a predominant Th2 response in opposition to a predominant Th1 response in CD163+/+ mice. th2 193-196 CD163 antigen Mus musculus 140-145 32608482-4 2020 In this study, we determined the role of ITGB4 of AECs in the regulation of Th2 response and identify the underpinning molecular mechanisms. th2 76-79 integrin subunit beta 4 Homo sapiens 41-46 32608482-8 2020 Together, these results demonstrated the involvement of ITGB4 deficiency in the development of Th2 responses of allergic asthma by down-regulation of EGFR and CCL17 pathway in AECs. th2 95-98 integrin beta 4 Mus musculus 56-61 32608482-8 2020 Together, these results demonstrated the involvement of ITGB4 deficiency in the development of Th2 responses of allergic asthma by down-regulation of EGFR and CCL17 pathway in AECs. th2 95-98 epidermal growth factor receptor Mus musculus 150-154 32608482-8 2020 Together, these results demonstrated the involvement of ITGB4 deficiency in the development of Th2 responses of allergic asthma by down-regulation of EGFR and CCL17 pathway in AECs. th2 95-98 chemokine (C-C motif) ligand 17 Mus musculus 159-164 32399548-6 2020 These data reveal a hitherto unappreciated role for an IL-10-STAT3-Blimp-1 circuit as an initiator of an inflammatory Th2 response in the lung to allergens. th2 118-121 interleukin 10 Homo sapiens 55-60 32399548-6 2020 These data reveal a hitherto unappreciated role for an IL-10-STAT3-Blimp-1 circuit as an initiator of an inflammatory Th2 response in the lung to allergens. th2 118-121 signal transducer and activator of transcription 3 Homo sapiens 61-66 32399548-6 2020 These data reveal a hitherto unappreciated role for an IL-10-STAT3-Blimp-1 circuit as an initiator of an inflammatory Th2 response in the lung to allergens. th2 118-121 PR/SET domain 1 Homo sapiens 67-74 32240120-0 2020 Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses. th2 81-84 exophilin 5 Mus musculus 0-11 32240120-0 2020 Exophilin-5 regulates allergic airway inflammation by controlling IL-33-mediated Th2 responses. th2 81-84 interleukin 33 Mus musculus 66-71 32255764-8 2020 As this KLF2/S1PR1 axis represents the essential cell-intrinsic regulator of T cell lymph node egress, we conclude that the druggable Notch signaling pathway licenses the Th2 response in allergic airway inflammation via promoting lymph node egress. th2 171-174 Kruppel-like factor 2 (lung) Mus musculus 8-12 32255764-8 2020 As this KLF2/S1PR1 axis represents the essential cell-intrinsic regulator of T cell lymph node egress, we conclude that the druggable Notch signaling pathway licenses the Th2 response in allergic airway inflammation via promoting lymph node egress. th2 171-174 sphingosine-1-phosphate receptor 1 Mus musculus 13-18 32510472-6 2020 Exophilin-5-deficient mice and asthma mouse models revealed that exophilin-5 regulates IL-33 production and the Th2 response. th2 112-115 exophilin 5 Mus musculus 65-76 32510472-7 2020 Notably, exophilin-5 deletion enhanced IL-33 release and pathogenic Th2 responsiveness through the mTOR pathway and altered intracellular IL-33 trafficking. th2 68-71 exophilin 5 Mus musculus 9-20 32088048-8 2020 However most recently, it was shown that the 16-cell stage bovine embryo starts to secrete interferon-tau (IFNT) that induces Th2 immune responses in the oviduct. th2 126-129 interferon tau-2 Bos taurus 91-105 32088048-8 2020 However most recently, it was shown that the 16-cell stage bovine embryo starts to secrete interferon-tau (IFNT) that induces Th2 immune responses in the oviduct. th2 126-129 interferon tau-2 Bos taurus 107-111 32088048-9 2020 Once developing embryos descend into the uterine horn, they induce Th2 responses with interferon-stimulated genes (ISGs) expression in the uterine epithelium and local immune cells mainly via IFNT release. th2 67-70 interferon tau-2 Bos taurus 192-196 32923130-3 2020 We demonstrate that human Treg cells do not suppress rather induce activation of basophils, and promote Th2 responses by IL-3 and STAT5-dependent mechanism. th2 104-107 interleukin 3 Homo sapiens 121-125 32923130-3 2020 We demonstrate that human Treg cells do not suppress rather induce activation of basophils, and promote Th2 responses by IL-3 and STAT5-dependent mechanism. th2 104-107 signal transducer and activator of transcription 5A Homo sapiens 130-135 32489402-12 2020 Conclusion: These data suggest that Majie cataplasm exert an anti-inflammatory effect of Th2 by rebalancing Th1/Th2 through corresponding transcription factor STAT6, GATA-3, STAT3, and T-bet, which providing a strong cornerstone for asthma control. th2 89-92 signal transducer and activator of transcription 6 Mus musculus 159-164 32489402-12 2020 Conclusion: These data suggest that Majie cataplasm exert an anti-inflammatory effect of Th2 by rebalancing Th1/Th2 through corresponding transcription factor STAT6, GATA-3, STAT3, and T-bet, which providing a strong cornerstone for asthma control. th2 89-92 GATA binding protein 3 Mus musculus 166-172 32489402-12 2020 Conclusion: These data suggest that Majie cataplasm exert an anti-inflammatory effect of Th2 by rebalancing Th1/Th2 through corresponding transcription factor STAT6, GATA-3, STAT3, and T-bet, which providing a strong cornerstone for asthma control. th2 89-92 signal transducer and activator of transcription 3 Mus musculus 174-179 32489402-12 2020 Conclusion: These data suggest that Majie cataplasm exert an anti-inflammatory effect of Th2 by rebalancing Th1/Th2 through corresponding transcription factor STAT6, GATA-3, STAT3, and T-bet, which providing a strong cornerstone for asthma control. th2 89-92 T-box 21 Mus musculus 185-190 32442188-4 2020 Despite being essential for host antiviral TH1 immunity, miR-155 may also contribute to respiratory disease by enhancing allergic TH2 responses and NFkB-mediated inflammation. th2 130-133 microRNA 155 Homo sapiens 57-64 32379832-7 2020 Furthermore, the overexpression of the epithelial Th2-related molecule TSLP was blunted, and normal TSLP and IL-4 levels were found in the bronchoalveolar lavage. th2 50-53 thymic stromal lymphopoietin Mus musculus 71-75 32089258-12 2020 These results imply that CCR5 deficiency facilitates Th17 airway inflammation during hRV-induced asthma exacerbation, along with suppressing Th2 responses. th2 141-144 C-C motif chemokine receptor 5 Homo sapiens 25-29 32238299-2 2020 METHODS: We delineate expansion methods using interleukin (IL)-2, IL-7 and allogeneic feeder cells and anti-CD2/CD3/CD28 stimulation by which to dependably augment Th2 polarization and direct cytotoxicity of human peripheral blood CD3+Valpha24+Vbeta11+ iNKT cells. th2 164-167 interleukin 2 Homo sapiens 46-64 32238299-2 2020 METHODS: We delineate expansion methods using interleukin (IL)-2, IL-7 and allogeneic feeder cells and anti-CD2/CD3/CD28 stimulation by which to dependably augment Th2 polarization and direct cytotoxicity of human peripheral blood CD3+Valpha24+Vbeta11+ iNKT cells. th2 164-167 interleukin 7 Homo sapiens 66-70 32238299-2 2020 METHODS: We delineate expansion methods using interleukin (IL)-2, IL-7 and allogeneic feeder cells and anti-CD2/CD3/CD28 stimulation by which to dependably augment Th2 polarization and direct cytotoxicity of human peripheral blood CD3+Valpha24+Vbeta11+ iNKT cells. th2 164-167 CD2 molecule Homo sapiens 108-111 32238299-2 2020 METHODS: We delineate expansion methods using interleukin (IL)-2, IL-7 and allogeneic feeder cells and anti-CD2/CD3/CD28 stimulation by which to dependably augment Th2 polarization and direct cytotoxicity of human peripheral blood CD3+Valpha24+Vbeta11+ iNKT cells. th2 164-167 CD28 molecule Homo sapiens 116-120 31925326-8 2020 Upregulation of PAR-2 and thymic stromal lymphopoietin (TSLP), which induce Th2-mediated allergic responses, was inhibited by Nax knockdown. th2 76-79 F2R like trypsin receptor 1 Homo sapiens 16-21 31925326-8 2020 Upregulation of PAR-2 and thymic stromal lymphopoietin (TSLP), which induce Th2-mediated allergic responses, was inhibited by Nax knockdown. th2 76-79 thymic stromal lymphopoietin Homo sapiens 26-54 31925326-8 2020 Upregulation of PAR-2 and thymic stromal lymphopoietin (TSLP), which induce Th2-mediated allergic responses, was inhibited by Nax knockdown. th2 76-79 thymic stromal lymphopoietin Homo sapiens 56-60 32336980-10 2020 The gene targets of these metabolites were significantly enriched in interleukin-4 and interleukin-13 pathways, implying that Biqi could ameliorate Th2-derived inflammatory response. th2 148-151 interleukin 4 Homo sapiens 69-82 32336980-10 2020 The gene targets of these metabolites were significantly enriched in interleukin-4 and interleukin-13 pathways, implying that Biqi could ameliorate Th2-derived inflammatory response. th2 148-151 interleukin 13 Homo sapiens 87-101 32312317-5 2020 Soluble NG-34 was mixed with adjuvants like aluminium hydroxide (AH) and AddaVax, known to induce Th2 and humoral responses; CAF01 which displays a biased Th1/Th17 profile and Diluvac Forte which augments the humoral response. th2 98-101 DNA segment, Chr 17, human D6S53E Mus musculus 8-13 32286393-7 2020 IL-33 had a direct immunomodulatory impact by increasing Th2 and Tregs. th2 57-60 interleukin 33 Homo sapiens 0-5 32286393-8 2020 IL-33 and MC further enhanced Th2 and regulatory responses by inducing a 6.1 fold increased proportion of Tregs (p = 0.008). th2 30-33 interleukin 33 Homo sapiens 0-5 32351590-0 2020 Yupingfeng Granule Improves Th2-Biased Immune State in Microenvironment of Hepatocellular Carcinoma through TSLP-DC-OX40L Pathway. th2 28-31 thymic stromal lymphopoietin Mus musculus 108-112 32351590-0 2020 Yupingfeng Granule Improves Th2-Biased Immune State in Microenvironment of Hepatocellular Carcinoma through TSLP-DC-OX40L Pathway. th2 28-31 tumor necrosis factor (ligand) superfamily, member 4 Mus musculus 116-121 32351590-3 2020 TSLP-OX40L pathway is a target to improve Th2 immunosuppression. th2 42-45 thymic stromal lymphopoietin Mus musculus 0-4 32351590-3 2020 TSLP-OX40L pathway is a target to improve Th2 immunosuppression. th2 42-45 tumor necrosis factor (ligand) superfamily, member 4 Mus musculus 5-10 32309281-11 2020 Conclusion: A combination of IL-17RB, ST2, and TSLPR signals amplified the Th2-polarizing function of DCs and was associated with disease severity in AR patients. th2 75-78 interleukin 17 receptor B Homo sapiens 29-36 32309281-11 2020 Conclusion: A combination of IL-17RB, ST2, and TSLPR signals amplified the Th2-polarizing function of DCs and was associated with disease severity in AR patients. th2 75-78 ST2 Homo sapiens 38-41 32309281-11 2020 Conclusion: A combination of IL-17RB, ST2, and TSLPR signals amplified the Th2-polarizing function of DCs and was associated with disease severity in AR patients. th2 75-78 cytokine receptor like factor 2 Homo sapiens 47-52 32268424-6 2020 The hyperprolactinemic group had significantly higher levels of Th2 associated CCL22 (p=0.022), Th17 associated CXCL1 (p=0.001), B cell attracting CXCL13 (p=0.003), and C-reactive protein (p<0.001) compared to controls, and these proteins were also positively correlated with prolactin levels. th2 64-67 prolactin Homo sapiens 9-18 32292403-2 2020 In addition, IL-33 has also been shown to work as a positive regulator that initiates and maintains a Th2 immune response. th2 102-105 interleukin 33 Mus musculus 13-18 32214904-1 2020 Background: Recent studies suggest that leptin is involved in Th2 response in allergic rhinitis (AR). th2 62-65 leptin Homo sapiens 40-46 31734286-16 2020 This study contributes to a better understanding of the IL-4/13A system in salmon, which as a key axis for Th2 response may be involved not only in pathogen elimination but also in adaptive immune repair that seems critical tolerance to infectious diseases. th2 107-110 interleukin 4/13A Salmo salar 56-64 31919905-12 2020 Collectively, our results demonstrate that pDCs suppress Th2 responses induced by EC sensitization via IFNalpha-mediated regulation of dDCs. th2 57-60 interferon alpha Mus musculus 103-111 31758869-0 2020 Lactococcus lactis harbouring Ara h 2.02 alleviates allergen-specific Th2-associated responses in sensitized mice. th2 70-73 retinoic acid receptor, alpha Rattus norvegicus 30-33 31758869-8 2020 CONCLUSIONS: Oral administration of rLl harbouring Ara h 2.02 demonstrated alleviation of Th2-associated responses in allergen-challenged mice and a possible added allergen-specific prophylactic effect. th2 90-93 retinoic acid receptor, alpha Rattus norvegicus 51-54 31904187-2 2020 We previously reported that in Th2 environment, the production and secretion of thymic stromal lymphopoietin (TSLP) from human keratinocytes was inhibited by recombinant heat shock protein 70 (rHSP70). th2 31-34 thymic stromal lymphopoietin Homo sapiens 80-108 31904187-2 2020 We previously reported that in Th2 environment, the production and secretion of thymic stromal lymphopoietin (TSLP) from human keratinocytes was inhibited by recombinant heat shock protein 70 (rHSP70). th2 31-34 thymic stromal lymphopoietin Homo sapiens 110-114 31904187-2 2020 We previously reported that in Th2 environment, the production and secretion of thymic stromal lymphopoietin (TSLP) from human keratinocytes was inhibited by recombinant heat shock protein 70 (rHSP70). th2 31-34 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 193-199 31155348-8 2020 CONCLUSION: Our results suggested that decreased IL-27 expression in AR were correlated with Th2 response. th2 93-96 interleukin 27 Homo sapiens 49-54 31330220-0 2020 Peptides from allergenic lipocalins bind to formyl peptide receptor 3 in human dendritic cells to mediate TH2 immunity. th2 106-109 formyl peptide receptor 3 Homo sapiens 44-69 31330220-12 2020 FPR3 silencing in DCs or pretreatment with an antagonistic peptide restores IL-12 and induces IL-10 expression by DCs treated with lipocalin allergens, attenuating the TH2 bias and inducing IL-10 production in cocultured TH cells. th2 168-171 formyl peptide receptor 3 Homo sapiens 0-4 31753545-2 2020 In this forum we summarize the main effects of the NLRP3 inflammasome activation, including control of excessive Th2 response and immunopathology induction. th2 113-116 NLR family pyrin domain containing 3 Homo sapiens 51-56 31648923-13 2020 CONCLUSIONS: The percentages and numbers of cTFH2 and ICOS+ cTFH cells might be useful as biomarkers of TH2 typed airway inflammation in patients with AA. th2 104-107 inducible T cell costimulator Homo sapiens 54-58 31708110-3 2020 We hypothesized that MIF contributed to HDM-induced the production of Th2-associated cytokines and E-cadherin dysfunction in asthmatic mice and 16HBE cells. th2 70-73 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 21-24 32124816-5 2020 The degree of clinical manifestation of preeclampsia has a correlation relationship with IL-10 deficiency and with the increase in TNF-alpha, stimulation of macrophage-protein production that contributes to the change in the ratio of Thl / Th2, which are antagonists and inhibit each other"s development. th2 240-243 tumor necrosis factor Homo sapiens 131-140 31638598-7 2019 Thus, P2Y6 receptor signaling drives an innate macrophage/IL-12/NK cell/IFN-gamma axis that prevents inappropriate allergic type 2 immune responses on respiratory allergen exposure and counteracts the Th2 priming effect of CysLT1R signaling at sensitization. th2 201-204 interferon gamma Mus musculus 72-81 31397016-0 2019 Chitinase 3-like 1 drives allergic skin inflammation via Th2 immunity and M2 macrophage activation. th2 57-60 chitinase-like 1 Mus musculus 0-18 31269241-0 2019 Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression. th2 33-36 TNF superfamily member 4 Homo sapiens 73-84 31269241-0 2019 Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression. th2 33-36 C-C motif chemokine ligand 17 Homo sapiens 89-94 31269241-4 2019 Here, we extended our previous work to examine the immunomodulatory effect of statins on allergic responses, particularly the TSLP-dependent Th2 pathway induced by myeloid DCs. th2 141-144 thymic stromal lymphopoietin Homo sapiens 126-130 31454522-11 2019 Blockade of CCL2/CCR2 signaling pathway in sensitization-recruited inflammatory monocytes exhibits protective effects in mouse model of OVA-induced allergic asthma by inhibiting the Th2 inflammatory responses. th2 182-185 chemokine (C-C motif) ligand 2 Mus musculus 12-16 31454522-11 2019 Blockade of CCL2/CCR2 signaling pathway in sensitization-recruited inflammatory monocytes exhibits protective effects in mouse model of OVA-induced allergic asthma by inhibiting the Th2 inflammatory responses. th2 182-185 chemokine (C-C motif) receptor 2 Mus musculus 17-21 31454522-11 2019 Blockade of CCL2/CCR2 signaling pathway in sensitization-recruited inflammatory monocytes exhibits protective effects in mouse model of OVA-induced allergic asthma by inhibiting the Th2 inflammatory responses. th2 182-185 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 136-139 31329326-8 2019 Inhibition of pulmonary Th2 responses was associated with increased IL-10 production but not with IFN-gamma production. th2 24-27 interleukin 10 Mus musculus 68-73 31434203-11 2019 These findings suggest that IL-4 mediates IL-31RA expression and IL-31/IL-31RA interaction augments Ccl 17 and Ccl 22 production in BMDCs, which promotes Th2-deviated immune response in AD. th2 154-157 interleukin 4 Mus musculus 28-32 31434203-11 2019 These findings suggest that IL-4 mediates IL-31RA expression and IL-31/IL-31RA interaction augments Ccl 17 and Ccl 22 production in BMDCs, which promotes Th2-deviated immune response in AD. th2 154-157 interleukin 31 receptor A Mus musculus 71-78 31434203-11 2019 These findings suggest that IL-4 mediates IL-31RA expression and IL-31/IL-31RA interaction augments Ccl 17 and Ccl 22 production in BMDCs, which promotes Th2-deviated immune response in AD. th2 154-157 chemokine (C-C motif) ligand 17 Mus musculus 100-106 31434203-11 2019 These findings suggest that IL-4 mediates IL-31RA expression and IL-31/IL-31RA interaction augments Ccl 17 and Ccl 22 production in BMDCs, which promotes Th2-deviated immune response in AD. th2 154-157 chemokine (C-C motif) ligand 22 Mus musculus 111-117 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 90-93 interleukin 4 Mus musculus 43-47 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 90-93 KH-type splicing regulatory protein Mus musculus 158-162 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 122-125 interleukin 4 Mus musculus 43-47 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 122-125 KH-type splicing regulatory protein Mus musculus 158-162 31511826-9 2019 These data indicate that overexpression of IL-4, which constitutes the primary inducer of Th2 polarization, may cause the Th2 bias of polyclonally stimulated KSRP-/- CD4+ T cells. th2 122-125 CD4 antigen Mus musculus 166-169 31511826-11 2019 We present strong evidence that T cells derived from KSRP-/- mice favor Th2-driven immune responses. th2 72-75 KH-type splicing regulatory protein Mus musculus 53-57 31318916-8 2019 Lower but sustained IL-4 production refers to Th2 predominance in higher stages of fibrosis. th2 46-49 interleukin 4 Homo sapiens 20-24 31189975-10 2019 Pursuing the Th2 adaptive immune response further we demonstrate that Cav1 knockout mice retained their ability to expel the intestinal nematode parasite T.muris, which requires adaptive Th2 immune response for elimination. th2 13-16 caveolin 1, caveolae protein Mus musculus 70-74 31189975-10 2019 Pursuing the Th2 adaptive immune response further we demonstrate that Cav1 knockout mice retained their ability to expel the intestinal nematode parasite T.muris, which requires adaptive Th2 immune response for elimination. th2 187-190 caveolin 1, caveolae protein Mus musculus 70-74 31055250-7 2019 In contrast, Th2 stimuli strongly upregulated the levels of COL1 and IL-4, while the expression levels of the other factors were minimally affected or even inhibited. th2 13-16 interleukin 4 Homo sapiens 69-73 30715796-4 2019 This study aims to elucidate the role of survivin in the development and maintenance of Th2 polarization. th2 88-91 baculoviral IAP repeat-containing 5 Mus musculus 41-49 30715796-6 2019 Mice carrying CD4+ T cells with survivin knockout (KO mice) were employed to test the role of survivin in the development of the biased Th2 responses. th2 136-139 baculoviral IAP repeat-containing 5 Mus musculus 94-102 30715796-13 2019 CONCLUSION: Survivin facilitates the development of biased Th2 polarization through promoting expression of interleukin 4 (IL-4) and impairing the AICD machinery of CD4+ T cells. th2 59-62 baculoviral IAP repeat-containing 5 Mus musculus 12-20 30715796-13 2019 CONCLUSION: Survivin facilitates the development of biased Th2 polarization through promoting expression of interleukin 4 (IL-4) and impairing the AICD machinery of CD4+ T cells. th2 59-62 interleukin 4 Mus musculus 108-121 30715796-13 2019 CONCLUSION: Survivin facilitates the development of biased Th2 polarization through promoting expression of interleukin 4 (IL-4) and impairing the AICD machinery of CD4+ T cells. th2 59-62 interleukin 4 Mus musculus 123-127 30715796-13 2019 CONCLUSION: Survivin facilitates the development of biased Th2 polarization through promoting expression of interleukin 4 (IL-4) and impairing the AICD machinery of CD4+ T cells. th2 59-62 CD4 antigen Mus musculus 165-168 30367458-10 2019 The improved Th1 environment helps to alleviate Th2-mediated allergic asthma by repairing the STAT1 pathway but not the STAT4 pathway. th2 48-51 signal transducer and activator of transcription 1 Homo sapiens 94-99 31097998-0 2019 Development of alpha-GalCer Analogues with an alpha-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d. th2 77-80 CD1d molecule Homo sapiens 102-106 31001272-8 2019 Under Th2 polarization conditions, transcription factor STAT6, which operates downstream of the cytokine signaling binds to the P2 and P3 promoters. th2 6-9 signal transducer and activator of transcription 6 Homo sapiens 56-61 30402955-14 2019 CHI3L1 could be a potential therapeutic candidate for attenuating Th2-associated immunopathology during RSV infection. th2 66-69 chitinase 3 like 1 Homo sapiens 0-6 30694585-3 2019 This study aims to elucidate the contribution of Bcl2L12 to Th2 polarization in patients with allergic rhinitis (AR). th2 60-63 BCL2 like 12 Homo sapiens 49-56 30390302-6 2019 RESULTS: Genetical or pharmacological interruption of LTB4-BLT1 axis during sensitization phase markedly reduced papain-induced IL-33 expression, decreased ILC2 activation and DC migration, thereby impairing the priming of allergic Th2 responses. th2 232-235 leukotriene B4 receptor 1 Mus musculus 59-63 30412784-6 2019 The increases in IL-10 and TGF-beta1 production may be due to the Th2 response and/or regulatory T cells (Tregs). th2 66-69 interleukin 10 Homo sapiens 17-22 30412784-6 2019 The increases in IL-10 and TGF-beta1 production may be due to the Th2 response and/or regulatory T cells (Tregs). th2 66-69 transforming growth factor beta 1 Homo sapiens 27-36 30642984-1 2019 The cytokine IL-33 is a well-established inducer of Th2 responses. th2 52-55 interleukin 33 Mus musculus 13-18 30442459-9 2019 Type II diabetes associated with Th2 mediated inflammation: IL-5 (P < 0.001), IL-7 (P = 0.004) and IL-13 (P = 0.015). th2 33-36 interleukin 5 Homo sapiens 60-64 30442459-9 2019 Type II diabetes associated with Th2 mediated inflammation: IL-5 (P < 0.001), IL-7 (P = 0.004) and IL-13 (P = 0.015). th2 33-36 interleukin 7 Homo sapiens 78-82 30442459-9 2019 Type II diabetes associated with Th2 mediated inflammation: IL-5 (P < 0.001), IL-7 (P = 0.004) and IL-13 (P = 0.015). th2 33-36 interleukin 13 Homo sapiens 99-104 30223113-8 2019 The Th2 (IL-13) and Th22-related products (IL-22, S100A8/9/12) and serum IgE were significantly correlated with clinical severity (Scoring of Atopic Dermatitis [SCORAD]) in AA. th2 4-7 interleukin 13 Homo sapiens 9-14 31505505-1 2019 BACKGROUND: Previous studies have used serum periostin levels as a biomarker of Th2-driven inflammatory responses. th2 80-83 periostin Homo sapiens 45-54 30227178-0 2019 Bcl2-like protein 12 plays a critical role in development of airway allergy through inducing aberrant TH2 polarization. th2 102-105 BCL2 like 12 Homo sapiens 0-20 31177502-5 2019 This immune response was described as a modified Th2 response, since both IgE and IgG4 require Th2 cytokine IL-4 for their production. th2 49-52 interleukin 4 Homo sapiens 108-112 29777594-10 2018 CONCLUSION: IL-3-dependent basophils promote Th2 allergic AHR, which designates the IL-3/basophil axis as a promising therapeutic target for the treatment of basophil-dependent asthma. th2 45-48 interleukin 3 Mus musculus 12-16 29777594-10 2018 CONCLUSION: IL-3-dependent basophils promote Th2 allergic AHR, which designates the IL-3/basophil axis as a promising therapeutic target for the treatment of basophil-dependent asthma. th2 45-48 interleukin 3 Mus musculus 84-88 30483264-6 2018 Moreover, adoptive transfer of activated Zeb1 KD DCs cleared intestinal worms in helminth infected mice by increasing Th2 responses in vivo. th2 118-121 zinc finger E-box binding homeobox 1 Mus musculus 41-45 30483264-8 2018 In addition, differentially regulated genes in Zeb1 KD RNA-seq showed significant enrichment of Th2 activation pathways supporting our in vitro findings. th2 96-99 zinc finger E-box binding homeobox 1 Mus musculus 47-51 30483264-9 2018 Mechanistically, we showed that decreased IL-12 secreted by Zeb1 KD DCs is the plausible mechanism for increased Th2 differentiation. th2 113-116 zinc finger E-box binding homeobox 1 Mus musculus 60-64 30030528-5 2018 Further, in vitro-generated OVA-presenting DCs of the KO induce only a weak Th2 response in the WT recipient mice upon re-exposure to OVA. th2 76-79 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 28-31 29879994-7 2018 Linear regression analysis of serum periostin showed positive correlations age (B = 0.02, 95%CI 0.01-0.03) and FEV1% predicted (B = 0.01, 95%CI 0.01-0.02) in healthy smokers, but not in COPD patients In conclusion, COPD -smokers and -past-smokers have significantly higher periostin levels compared to healthy smokers, yet periostin is not suitable as a biomarker for Th2-driven inflammation or ICS-responsiveness in COPD. th2 368-371 periostin Homo sapiens 36-45 29673285-9 2018 Incorporation of combination adjuvants containing TLR3, TLR4 and TLR7/8 agonists to neonatal vaccines may be an effective strategy to overcome neonatal Th2 bias. th2 152-155 toll like receptor 3 Homo sapiens 50-54 29673285-9 2018 Incorporation of combination adjuvants containing TLR3, TLR4 and TLR7/8 agonists to neonatal vaccines may be an effective strategy to overcome neonatal Th2 bias. th2 152-155 toll like receptor 7 Homo sapiens 65-69 29662241-3 2018 The levels of Th2 related chemokine (C-C motif) ligand 17 (CCL17) and CCL22 were quantified in cord blood and at 1.5 years-of-age using multiplex Luminex kits. th2 14-17 C-C motif chemokine ligand 17 Homo sapiens 59-64 29662241-8 2018 In conclusion, low mother-to-child Th2-associated chemokine CCL22 levels appear to be inversely related to mite sensitization and the risk of asthma development in early childhood. th2 35-38 C-C motif chemokine ligand 22 Homo sapiens 60-65 29425937-3 2018 In the Lyn-/- and FcgammaIIB-/-.Yaa lupus mouse models, autoreactive IgE activate basophils, and promote a Th2 environment with, subsequently, production of autoantibodies by plasma cells. th2 107-110 immunoglobulin heavy constant epsilon Homo sapiens 69-72 29107385-7 2018 Therefore, CCL2 secreted from the tumor microenvironment may attract and interact with monocytes/macrophages, and favor Th2 accumulation by inducing CCL22 secretion. th2 120-123 C-C motif chemokine ligand 2 Homo sapiens 11-15 32476888-7 2018 The Th2 pathway with an elevated CCL-18 (marker of M2) concentration in the bronchoalveolar lavage fluid (BALF) is linked to fibrosis in ILDs. th2 4-7 C-C motif chemokine ligand 18 Homo sapiens 33-39 28906131-13 2017 An important new group of promising sole Th2 adjuvants are the fucosylated glycans, which by binding to DC-SIGN bias dendritic cells to Th2 immunity while inhibiting Th1/Th7 immunities. th2 41-44 negative elongation factor complex member C/D Homo sapiens 166-169 29036225-6 2017 In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation. th2 30-33 serine (or cysteine) peptidase inhibitor, clade G, member 1 Mus musculus 15-21 28275684-4 2017 Thus, a paradox occurs; why is TSLP homeostatic in certain tissues and a hallmark of exacerbated Th2 responses in the aforementioned pathologies? th2 97-100 thymic stromal lymphopoietin Homo sapiens 31-35 27794000-0 2016 Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens. th2 34-37 kinesin family member 3A Homo sapiens 18-23 27693663-0 2016 Active immunization with the peptide epitope vaccine Abeta3-10-KLH induces a Th2-polarized anti-Abeta antibody response and decreases amyloid plaques in APP/PS1 transgenic mice. th2 77-80 aspartoacylase (aminoacylase) 3 Mus musculus 53-59 27693663-0 2016 Active immunization with the peptide epitope vaccine Abeta3-10-KLH induces a Th2-polarized anti-Abeta antibody response and decreases amyloid plaques in APP/PS1 transgenic mice. th2 77-80 amyloid beta (A4) precursor protein Mus musculus 53-58 27693663-0 2016 Active immunization with the peptide epitope vaccine Abeta3-10-KLH induces a Th2-polarized anti-Abeta antibody response and decreases amyloid plaques in APP/PS1 transgenic mice. th2 77-80 presenilin 1 Mus musculus 157-160 27693663-5 2016 Abeta3-10-KLH elicited a robust Th2-polarized anti-Abeta antibody response and inhibited Abeta deposition in APP/PS1 mice. th2 32-35 aspartoacylase (aminoacylase) 3 Mus musculus 0-6 27693663-5 2016 Abeta3-10-KLH elicited a robust Th2-polarized anti-Abeta antibody response and inhibited Abeta deposition in APP/PS1 mice. th2 32-35 amyloid beta (A4) precursor protein Mus musculus 0-5 27693663-5 2016 Abeta3-10-KLH elicited a robust Th2-polarized anti-Abeta antibody response and inhibited Abeta deposition in APP/PS1 mice. th2 32-35 amyloid beta (A4) precursor protein Mus musculus 51-56 27634421-8 2016 The increased concentrations of IL-10 and decreased concentrations of TNF-alpha and IL-2 are characteristic of a Th2-enhanced response, which may be related to increased concentrations of NO. th2 113-116 interleukin-10 Capra hircus 32-37 27634421-8 2016 The increased concentrations of IL-10 and decreased concentrations of TNF-alpha and IL-2 are characteristic of a Th2-enhanced response, which may be related to increased concentrations of NO. th2 113-116 tumor necrosis factor Capra hircus 70-79 27634421-8 2016 The increased concentrations of IL-10 and decreased concentrations of TNF-alpha and IL-2 are characteristic of a Th2-enhanced response, which may be related to increased concentrations of NO. th2 113-116 interleukin-2 Capra hircus 84-88 27315109-6 2016 More importantly, Th2-promoting adjuvant activities by alum found in IL-4 knockout mice were also largely reduced when basophils were depleted by antibody administration. th2 18-21 interleukin 4 Mus musculus 69-73 27315109-7 2016 Therefore, basophils can mediate Th2-promoting activities by alum both in vitro and in vivo through IL-4-independent mechanisms. th2 33-36 interleukin 4 Mus musculus 100-104 27315109-9 2016 Finally, alum was able to activate NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in murine basophils in the same way as alum in professional antigen-presenting cells, but NLRP3 was not required for Th2-promoting activities on basophils by alum in vitro. th2 221-224 NLR family, pyrin domain containing 3 Mus musculus 84-89 27302755-6 2016 Our results revealed a novel circuit in DCs for Th2 polarization that is governed by KLF2. th2 48-51 Kruppel like factor 2 Homo sapiens 85-89 27091976-6 2016 Antigen-conjugated NPs made of biodegradable poly(lactide-co-glycolide) (Ag-PLG) are similarly effective prophylactically, are well tolerated by sensitized animals, but only partially inhibit Th2 responses when administered therapeutically. th2 192-195 plasminogen Mus musculus 76-79 26180083-6 2016 GBM patient sera samples induce high levels of CD163 expression when added to normal monocytes, providing mechanistic evidence of a basis for Th2 bias. th2 142-145 CD163 molecule Homo sapiens 47-52 25944053-9 2015 Furthermore, miR-155(-/-) DCs showed limited Th2 priming capacity and failed to induce airway inflammation in allergen-exposed WT mice. th2 45-48 microRNA 155 Mus musculus 13-20 25944053-11 2015 CONCLUSIONS: miR-155 deficiency alleviates AAI by diminishing Th2 priming capacity and ATP-/P2R-induced activation of DCs in mice, suggesting this miRNA as a potential therapeutic target of AAI. th2 62-65 microRNA 155 Mus musculus 13-20 26054303-2 2015 The percentage of nNOS-immunoreactive (IR) neurons decreased after capsaicin treatment in all studied ganglia in first 20 days of life, from 55.4% to 36.9% in the Th2 DRG, from 54.6% to 26.1% in the L4 DRG and from 37.1% to 15.0% in the NG. th2 163-166 nitric oxide synthase 1 Rattus norvegicus 18-22 25689082-7 2015 The Soluble form of GPI-HER-2 induced only a weak Th2 response under similar conditions. th2 50-53 erb-b2 receptor tyrosine kinase 2 Mus musculus 24-29 25899693-5 2015 Periostin is considered a marker of TH2-induced airway inflammation and a predictor of response to drugs such as anti-IL13 and omalizumab, although at the individual level, such prediction remains imperfect. th2 36-39 periostin Homo sapiens 0-9 25595257-3 2015 In-vivo TNFRSF4/25 antibody co-stimulation enhanced Abeta42 specific T cell responses with initial Th2 expansion and subsequent development of Abeta42 specific CD4+CD25+Foxp3+ cells. th2 99-102 tumor necrosis factor receptor superfamily, member 4 Mus musculus 8-18 25541655-10 2014 We found remnant increased IL-4, which could be a clue for the triggering of the Th2 pathway in the background. th2 81-84 interleukin 4 Homo sapiens 27-31 25341798-9 2014 Th2 in both depots and peripheral blood was inversely associated with systemic insulin resistance. th2 0-3 insulin Homo sapiens 79-86 25236373-0 2014 AAV2/8-hSMAD3 gene delivery attenuates aortic atherogenesis, enhances Th2 response without fibrosis, in LDLR-KO mice on high cholesterol diet. th2 70-73 SMAD family member 3 Homo sapiens 7-13 24983378-4 2014 A IgG1-skewed isotype distribution was observed for the anti-Abeta antibodies generated in mice immunized with either the non-adjuvanted or the adjuvanted vaccine, indicating that (1-11)E2 induces a Th2-like response in all tested conditions. th2 199-202 LOC105243590 Mus musculus 2-6 24983378-4 2014 A IgG1-skewed isotype distribution was observed for the anti-Abeta antibodies generated in mice immunized with either the non-adjuvanted or the adjuvanted vaccine, indicating that (1-11)E2 induces a Th2-like response in all tested conditions. th2 199-202 histocompatibility 2, class II antigen A, beta 1 Mus musculus 61-66 24508458-3 2014 In a mouse model of asthma, the absence of Cbl-b results in severe airway inflammation and stronger Th2 and Th9 responses. th2 100-103 Casitas B-lineage lymphoma b Mus musculus 43-48 24283478-9 2014 Periostin may be a biomarker for Th2 induced airway inflammation. th2 33-36 periostin Homo sapiens 0-9 23943347-6 2013 CONCLUSION: TGF-beta, induced in the gut by VSL#3 supplementation, is capable of reducing the Th2 inflammation associated with food anaphylaxis in a mouse model of peanut sensitization. th2 94-97 transforming growth factor, beta 1 Mus musculus 12-20 23811304-10 2013 On immunohistochemistry, GATA3(+) Th2 lymphocytes and FOXP3(+) Tregs were significantly larger in number in IgG4-SC/AIP, with the GATA3(+)/T-bet(+) cell ratio to be shifted in favour of Th2 in periductal and perivascular areas. th2 34-37 GATA binding protein 3 Homo sapiens 25-30 23811304-10 2013 On immunohistochemistry, GATA3(+) Th2 lymphocytes and FOXP3(+) Tregs were significantly larger in number in IgG4-SC/AIP, with the GATA3(+)/T-bet(+) cell ratio to be shifted in favour of Th2 in periductal and perivascular areas. th2 34-37 GATA binding protein 3 Homo sapiens 130-135 23340773-9 2013 CONCLUSIONS: These data reveal an elevated serum concentration of Th2-attracting chemokines CCL22 and CCL17 in OMS. th2 66-69 C-C motif chemokine ligand 22 Homo sapiens 92-97 23340773-9 2013 CONCLUSIONS: These data reveal an elevated serum concentration of Th2-attracting chemokines CCL22 and CCL17 in OMS. th2 66-69 C-C motif chemokine ligand 17 Homo sapiens 102-107 23585480-7 2013 Our results suggest that allergen-specific IgG can enhance secondary responses by ligating FcgammaRIII on antigen-presenting cells to augment development of Th2-mediated responses in the lungs via an IL-33-dependent mechanism. th2 157-160 Fc gamma receptor IIIa Homo sapiens 91-102 23585480-7 2013 Our results suggest that allergen-specific IgG can enhance secondary responses by ligating FcgammaRIII on antigen-presenting cells to augment development of Th2-mediated responses in the lungs via an IL-33-dependent mechanism. th2 157-160 interleukin 33 Homo sapiens 200-205 23977659-8 2013 Moreover, the TH2 (CD4(+) CCR3(+) CCR4(+)) expression was 1.60% +- 1.05 for control group, 1.57% +- 0.83 for pre-T and 1.27% +- 0.66 for post-treatment group. th2 14-17 CD4 molecule Homo sapiens 19-22 23977659-8 2013 Moreover, the TH2 (CD4(+) CCR3(+) CCR4(+)) expression was 1.60% +- 1.05 for control group, 1.57% +- 0.83 for pre-T and 1.27% +- 0.66 for post-treatment group. th2 14-17 C-C motif chemokine receptor 3 Homo sapiens 26-30 23977659-8 2013 Moreover, the TH2 (CD4(+) CCR3(+) CCR4(+)) expression was 1.60% +- 1.05 for control group, 1.57% +- 0.83 for pre-T and 1.27% +- 0.66 for post-treatment group. th2 14-17 C-C motif chemokine receptor 4 Homo sapiens 34-38 23352844-11 2013 The induction of TSLP, which leads to systemic Th2 response, was reduced in the skin on combination treatment. th2 47-50 thymic stromal lymphopoietin Mus musculus 17-21 23240750-6 2012 This CD4(+)CD25(+)CD152(+) Treg increase may have inhibited Th2-stimulated IgA production by B cells. th2 60-63 CD4 molecule Homo sapiens 5-8 22709877-3 2012 This is probably because DCs, which combine with Th2 in the Tim-1/Tim-4 pathway, will induce Th2 to proliferation. th2 49-52 Rho guanine nucleotide exchange factor 5 Homo sapiens 60-65 22709877-3 2012 This is probably because DCs, which combine with Th2 in the Tim-1/Tim-4 pathway, will induce Th2 to proliferation. th2 49-52 T cell immunoglobulin and mucin domain containing 4 Homo sapiens 66-71 22709877-3 2012 This is probably because DCs, which combine with Th2 in the Tim-1/Tim-4 pathway, will induce Th2 to proliferation. th2 93-96 Rho guanine nucleotide exchange factor 5 Homo sapiens 60-65 22709877-3 2012 This is probably because DCs, which combine with Th2 in the Tim-1/Tim-4 pathway, will induce Th2 to proliferation. th2 93-96 T cell immunoglobulin and mucin domain containing 4 Homo sapiens 66-71 22626444-2 2012 We demonstrated that therapeutic immunization with Ad-10xAbeta3-10-CpG elicits Abeta3-10 specific Th2-polarized immune response with high titers of anti-Abeta antibodies in APPswe/PSEN1dE9 mice, which in turn reduced Abeta deposits in brains and cognitive impairment. th2 98-101 histocompatibility 2, class II antigen A, beta 1 Mus musculus 57-62 22627368-11 2012 CONCLUSIONS: Our findings suggest that Gal-9 negatively regulates Th2-mediated eosinophilic inflammation of the lung and that Foxp3+ regulatory T cells might be involved in suppressing allergic inflammation. th2 66-69 lectin, galactose binding, soluble 9 Mus musculus 39-44 22023479-5 2011 Another application of pDNA is as a "DNA vaccine" to induce immunity against amyloid Abeta in AD, which requires a predominantly Th2 response to avoid autoimmune encephalomyelitis evoked by a Th1 response. th2 129-132 amyloid beta precursor protein Homo sapiens 85-90 21804081-11 2011 Present data demonstrate for the first time that activation of the AhR by TCDD suppressed the development of Th2-mediated food allergic responses. th2 109-112 aryl-hydrocarbon receptor Mus musculus 67-70 21909267-0 2011 Th2-polarised PrP-specific transgenic T-cells confer partial protection against murine scrapie. th2 0-3 prion protein Mus musculus 14-17 21705620-8 2011 Blockade of GITR-GITRL interactions during the acute egg phase of S. mansoni infection resulted in reduced Th2 responses, but this effect was confined to the spleen and did not lead to changes in liver pathology. th2 107-110 tumor necrosis factor receptor superfamily, member 18 Mus musculus 12-16 21705620-8 2011 Blockade of GITR-GITRL interactions during the acute egg phase of S. mansoni infection resulted in reduced Th2 responses, but this effect was confined to the spleen and did not lead to changes in liver pathology. th2 107-110 tumor necrosis factor (ligand) superfamily, member 18 Mus musculus 17-22 21631300-1 2011 The single-nucleotide polymorphisms (SNPs) of the Mina gene in animals are associated with the development of Th2-mediated diseases. th2 110-113 ribosomal oxygenase 2 Homo sapiens 50-54 22778869-2 2011 In experiments in vitro using tau and beta-amyloid (Abeta) aggregates, the TH derivative, TH2, showed high specific binding to tau aggregates. th2 90-93 microtubule associated protein tau Homo sapiens 30-33 22778869-2 2011 In experiments in vitro using tau and beta-amyloid (Abeta) aggregates, the TH derivative, TH2, showed high specific binding to tau aggregates. th2 90-93 microtubule associated protein tau Homo sapiens 127-130 22778869-5 2011 [(123)I]TH2 should be further investigated as a potential imaging agent for detecting tau pathology. th2 8-11 microtubule associated protein tau Homo sapiens 86-89 21436014-12 2011 The Th1/Th2 ratio was significantly lower in the LAC-PD group when compared both to LAC/BIC-PD and ICO-PD groups. th2 8-11 negative elongation factor complex member C/D Homo sapiens 4-7 32272526-3 2011 Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. th2 194-197 interleukin 19 Homo sapiens 150-155 20819926-0 2010 CD11c depletion severely disrupts Th2 induction and development in vivo. th2 34-37 integrin subunit alpha X Homo sapiens 0-5 20720210-6 2010 We found, however, that coadministration of a novel emulsome adjuvant, which enhances Th2 responses, resulted in the induction of LAP(+) regulatory T cells and suppression of ongoing arthritis by both nasal and oral anti-CD3. th2 86-89 LAP Homo sapiens 130-133 20505746-4 2010 In this study, we investigated the role of eotaxins in the development of the Th2 environment of CTCL. th2 78-81 TSPY like 2 Homo sapiens 97-101 20472307-10 2010 The relative RORgammaT levels in PBMCs negatively correlated with the Th1/Th2 ratio in CD4(+) cells in MG patients (p=0.014). th2 74-77 CD4 molecule Homo sapiens 87-90 20610655-8 2010 In conclusion, our work demonstrates a major role for MR in glycoallergen recognition and in the development of Th2 responses. th2 112-115 mannose receptor C-type 1 Homo sapiens 54-56 20562015-6 2010 Antibodies were found to be primarily IgG1 suggesting a predominant Th2 response (IgG1/IgG2a ratio of 9). th2 68-71 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 82-86 20562015-6 2010 Antibodies were found to be primarily IgG1 suggesting a predominant Th2 response (IgG1/IgG2a ratio of 9). th2 68-71 immunoglobulin heavy variable V1-9 Mus musculus 87-92 20193034-8 2010 T-bet gene mutations may be associated with Th2-dominated condition in gastric cancers. th2 44-47 T-box transcription factor 21 Homo sapiens 0-5 20139660-8 2010 These are N-terminal short Abeta peptides with Th2 adjuvant or Th2-stimulating molecules, DNA vaccines, recombinant viral vector vaccines, recombinant vegetables and others. th2 47-50 amyloid beta precursor protein Homo sapiens 27-32 19197360-8 2009 These differences between Th1- and Th2-produced virions were greater for viruses lacking functional vif, but also seen with vif-positive viruses. th2 35-38 Vif Human immunodeficiency virus 1 100-103 19197360-8 2009 These differences between Th1- and Th2-produced virions were greater for viruses lacking functional vif, but also seen with vif-positive viruses. th2 35-38 Vif Human immunodeficiency virus 1 124-127 18496024-6 2008 RESULTS: Th2 adjuvant forskolin was qualitatively evaluated by an increased expression of Delta1 in PMA-treated THP-1 cells, as reported in our previous study. th2 9-12 delta like non-canonical Notch ligand 1 Homo sapiens 90-96 18496024-6 2008 RESULTS: Th2 adjuvant forskolin was qualitatively evaluated by an increased expression of Delta1 in PMA-treated THP-1 cells, as reported in our previous study. th2 9-12 GLI family zinc finger 2 Homo sapiens 112-117 18248380-8 2008 CONCLUSIONS: The significant changes in the Th2 level correlated with the therapeutic effect during the IFN alpha-2b plus ribavirin combination therapy. th2 44-47 interferon alpha 1 Homo sapiens 104-107 18566405-6 2008 Finally, phosphorylated signaling molecules colocalized with MHC/TCR to a greater extent in Th2 IS. th2 92-95 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 65-68 18163337-6 2007 Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI. th2 78-81 immunoglobulin heavy variable V1-9 Mus musculus 141-146 18163337-6 2007 Antigen-specific serum total immunoglobulin (Ig)G, IgG1, IgM, and IgA levels (Th2-induced) were elevated from days 7 to 14 to day 28 PI, and IgG2a (Th1-induced) was elevated at days 21 to 28 PI. th2 78-81 negative elongation factor complex member C/D, Th1l Mus musculus 148-151 17008395-8 2007 These changes were associated with increased Th2-promoting ERK phosphorylation in the presence of insulin. th2 45-48 insulin Homo sapiens 98-105 17132088-7 2006 Mannan induced a significant and highly polarized toward Th2 phenotype anti-Abeta antibody response not only in BALB/c, but also in B6SJL F1 mice. th2 57-60 amyloid beta (A4) precursor protein Mus musculus 76-81 17052395-6 2006 The percentage of TH1 in asthmatic patients decreased significantly compared with that in the Control group [(11.24 +/- 2.43)% vs (16.67 +/- 2.73)%; P < 0.01]; in contrast, the percentage of TH2 increased compared with that in the Control group [(19.85 +/- 4.46)% vs (16.08 +/- 6.17)%; P < 0.05]. th2 194-197 negative elongation factor complex member C/D Homo sapiens 18-21 16965687-19 2006 Furthermore, IFN-alpha could significantly decrease TH2 level. th2 52-55 interferon alpha 1 Homo sapiens 13-22 16569363-2 2006 There are sporadic case reports of atopic dermatitis (AD) induced or precipitated by anti-TNF-alpha therapy, which have been attributed to the switch towards Th2-mediated reactions. th2 158-161 tumor necrosis factor Homo sapiens 90-99 16081597-0 2005 Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production. th2 96-99 CD40 ligand Homo sapiens 40-45 16081597-0 2005 Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production. th2 96-99 interferon gamma Homo sapiens 143-153 16081597-0 2005 Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production. th2 96-99 negative elongation factor complex member C/D Homo sapiens 159-162 16007274-4 2005 Both in the spleen and mesenteric ganglia, the B1 and B2 cells were induced to switch from IgM to IgE in the early Th2-dominated phase of the disease, with an increase of IgE in its later phases. th2 115-118 B.burgdorferi-associated arthritis 2 Mus musculus 47-56 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 49-52 negative elongation factor complex member C/D Homo sapiens 45-48 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 49-52 hypertrichosis 2 (generalised, congenital) Homo sapiens 69-72 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 49-52 negative elongation factor complex member C/D Homo sapiens 90-93 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 49-52 negative elongation factor complex member C/D Homo sapiens 90-93 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 49-52 negative elongation factor complex member C/D Homo sapiens 90-93 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 94-97 negative elongation factor complex member C/D Homo sapiens 45-48 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 94-97 hypertrichosis 2 (generalised, congenital) Homo sapiens 69-72 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 94-97 negative elongation factor complex member C/D Homo sapiens 45-48 14551795-4 2004 There were negative correlations between the Th1:Th2 ratio and serum hCG levels (mIU/ml) (Th1:Th2 ratio = 14.5-4.52 x 10(-5)xhCG, r(2)=0.41, p<0.05) and between the Th1:Th2 ratio and serum progesterone levels (ng/dl; Th1:Th2 ratio = 23.0-0.63 x progesterone, r(2)=0.36, p<0.05). th2 94-97 hypertrichosis 2 (generalised, congenital) Homo sapiens 69-72 15233948-8 2004 The majority of anti-hFVIII IgG was IgG1 isotype specific, suggesting a humoral response mediated by Th2-induced signals. th2 101-104 LOC105243590 Mus musculus 36-40 15044085-8 2004 Thus, PGD(2) favors Th2 functions through CRTH2 while restraining Th1 functions via DP, which may contribute to development of Th2-dominated status in allergic inflammations. th2 20-23 prostaglandin D2 receptor 2 Homo sapiens 42-47 15086343-4 2004 We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. th2 70-73 chemokine (C-C motif) ligand 17 Mus musculus 33-37 15086343-4 2004 We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. th2 70-73 chemokine (C-C motif) ligand 17 Mus musculus 38-43 15204774-4 2004 Levels of immunoglobulin (Ig) G1 were significantly decreased from 1124 +/- 244 microg/ml in saline exposed mice to 614 +/- 204 microg/ml in silica-exposed mice, suggesting a decrease in the Th2 response. th2 191-194 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 10-32 14764715-8 2004 These results suggest that, when Ag-specific IgE is present in a filaria-infected individual, basophils function to amplify the ongoing Th2 response by releasing IL-4 in greater amounts and possibly more frequently than CD4(+) T cells in response to filarial Ag. th2 136-139 interleukin 4 Homo sapiens 162-166 15663363-5 2004 The aim of this review is to discuss our current understanding of the mode of action of PGD2 during Th2-mediated inflammation. th2 100-103 prostaglandin D2 synthase Homo sapiens 88-92 14700442-4 2003 OBJECTIVE: To determine the effect of the TH2 environment with interferon-gamma (IFN-gamma) and heat shock protein 70 (HSP 70) on CD23 receptor expression and tumor necrosis factor alpha (TNF-alpha) production. th2 42-45 interferon gamma Homo sapiens 63-79 14700442-4 2003 OBJECTIVE: To determine the effect of the TH2 environment with interferon-gamma (IFN-gamma) and heat shock protein 70 (HSP 70) on CD23 receptor expression and tumor necrosis factor alpha (TNF-alpha) production. th2 42-45 interferon gamma Homo sapiens 81-90 14700442-4 2003 OBJECTIVE: To determine the effect of the TH2 environment with interferon-gamma (IFN-gamma) and heat shock protein 70 (HSP 70) on CD23 receptor expression and tumor necrosis factor alpha (TNF-alpha) production. th2 42-45 Fc epsilon receptor II Homo sapiens 130-134 14700442-4 2003 OBJECTIVE: To determine the effect of the TH2 environment with interferon-gamma (IFN-gamma) and heat shock protein 70 (HSP 70) on CD23 receptor expression and tumor necrosis factor alpha (TNF-alpha) production. th2 42-45 tumor necrosis factor Homo sapiens 159-186 14700442-11 2003 CONCLUSIONS: Both IFN-gamma and HSP 70, in the TH2 environment, up-regulate CD23 expression and thus may play an important role in maintaining the chronic inflammatory state in asthma. th2 47-50 interferon gamma Homo sapiens 18-27 14700442-11 2003 CONCLUSIONS: Both IFN-gamma and HSP 70, in the TH2 environment, up-regulate CD23 expression and thus may play an important role in maintaining the chronic inflammatory state in asthma. th2 47-50 heat shock protein family A (Hsp70) member 4 Homo sapiens 32-38 14700442-11 2003 CONCLUSIONS: Both IFN-gamma and HSP 70, in the TH2 environment, up-regulate CD23 expression and thus may play an important role in maintaining the chronic inflammatory state in asthma. th2 47-50 Fc epsilon receptor II Homo sapiens 76-80 14500660-4 2003 Stat6 is the protein activated by signal transduction through the IL-4R, and studies with knockout mice demonstrate that Stat6 is critical for a number of IL-4-mediated functions including Th2 development and production of IgE. th2 189-192 signal transducer and activator of transcription 6 Mus musculus 0-5 14500660-4 2003 Stat6 is the protein activated by signal transduction through the IL-4R, and studies with knockout mice demonstrate that Stat6 is critical for a number of IL-4-mediated functions including Th2 development and production of IgE. th2 189-192 interleukin 4 receptor, alpha Mus musculus 66-71 14500660-4 2003 Stat6 is the protein activated by signal transduction through the IL-4R, and studies with knockout mice demonstrate that Stat6 is critical for a number of IL-4-mediated functions including Th2 development and production of IgE. th2 189-192 signal transducer and activator of transcription 6 Mus musculus 121-126 14500660-4 2003 Stat6 is the protein activated by signal transduction through the IL-4R, and studies with knockout mice demonstrate that Stat6 is critical for a number of IL-4-mediated functions including Th2 development and production of IgE. th2 189-192 interleukin 4 Mus musculus 66-70 12648458-2 2003 Correspondingly, Stat4 levels are greatly suppressed during physiological Th2 development. th2 74-77 signal transducer and activator of transcription 4 Homo sapiens 17-22 12402614-16 2002 Patients with a CD4:CD8 ratio < 1.1 produce more IFN-gamma and IL-12, and are more able to switch from TH2 to TH0. th2 106-109 CD4 molecule Homo sapiens 16-19 12002732-0 2002 Is Th1 the solution for Th2 in asthma? th2 24-27 negative elongation factor complex member C/D Homo sapiens 3-6 11776379-5 2001 We conclude that the Th1/Th2 balance was polarized to Th2 in untreated DLCL patients and to Th1 in patients in CR, which suggests that a Th1/Th2 imbalance could play a role in lymphomagenesis and durable remission. th2 25-28 negative elongation factor complex member C/D Homo sapiens 92-95 11776379-5 2001 We conclude that the Th1/Th2 balance was polarized to Th2 in untreated DLCL patients and to Th1 in patients in CR, which suggests that a Th1/Th2 imbalance could play a role in lymphomagenesis and durable remission. th2 25-28 negative elongation factor complex member C/D Homo sapiens 92-95 11477091-4 2001 In contrast, TLR2 stimulation failed to induce IL-12 p70 and interferon-gamma inducible protein (IP)-10 but resulted in the release of the IL-12 inhibitory p40 homodimer, producing conditions that are predicted to favor Th2 development. th2 220-223 toll like receptor 2 Homo sapiens 13-17 11477091-4 2001 In contrast, TLR2 stimulation failed to induce IL-12 p70 and interferon-gamma inducible protein (IP)-10 but resulted in the release of the IL-12 inhibitory p40 homodimer, producing conditions that are predicted to favor Th2 development. th2 220-223 interleukin 9 Homo sapiens 156-159 11564779-7 2001 rIL-10 reduced Th-induced ear swelling, although higher doses of rIL-10 were required in Th2-induced one. th2 89-92 interleukin 10 Rattus norvegicus 65-71 11369638-7 2001 These data suggest an additional level of the Th2-promoting activity of PGE(2), via selective induction of IL-12p40. th2 46-49 interleukin 12B Homo sapiens 107-115 11097309-8 2000 This study suggests that CD30 expression in circulating T cells might serve as an in vivo marker for the Th2-dominated condition. th2 105-108 TNF receptor superfamily member 8 Homo sapiens 25-29 10998023-18 2000 This Th2 environment could also be verified by CD23 and CD134 expression. th2 5-8 Fc epsilon receptor II Homo sapiens 47-51 10969181-4 2000 Paradoxically, however, hyperprolactinemia can also be associated with conditions such as pregnancy, where remission of Th1-mediated diseases is known to occur in the context of a Th2-dominated milieu. th2 180-183 negative elongation factor complex member C/D Homo sapiens 120-123 10799884-11 2000 CD4+ cells from IL-12-/- mice secreted less IFN-gamma, but more IL-4 and IL-10 than WT mice, suggesting that they developed a stronger Th2 response to TAChR. th2 135-138 CD4 antigen Mus musculus 0-3 10692059-11 2000 Mast cells do not seem to be primarily responsible for triggering hypersensitivity dermatoses among AIDS patients, although data in support of the Th2 response, as seen in increased IgE serum levels and DTH anergy, are present. th2 147-150 immunoglobulin heavy constant epsilon Homo sapiens 182-185 10375450-12 1999 In conclusion, a Th2-induced mouse conjunctival eosinophilia model was established in which D10 activation results in IL-4 and IL-5 release. th2 17-20 interleukin 4 Mus musculus 118-122 10375450-12 1999 In conclusion, a Th2-induced mouse conjunctival eosinophilia model was established in which D10 activation results in IL-4 and IL-5 release. th2 17-20 interleukin 5 Mus musculus 127-131 9781547-1 1998 OBJECTIVE: To ascertain the presence of the Th2 response in MS patients by evaluating the level of soluble (s) CD30 across the clinical spectrum of MS and during relapse and remission. th2 44-47 TNF receptor superfamily member 8 Homo sapiens 111-115 9503096-1 1998 Elevated levels of soluble CD30-sCD30 (possibly related to Th2) are seen in atopy and other diseases. th2 59-62 TNF receptor superfamily member 8 Homo sapiens 27-31 9404557-7 1997 These data support the view that Th0/Th2-type responses predominate in the skin of patients with AD and suggest that the presence of CD30+ T cells in tissues and/or increased levels of sCD30 in biologic fluids are indicative of Th2-dominated responses. th2 37-40 TNF receptor superfamily member 8 Homo sapiens 133-137 9257851-1 1997 The IgE/Fc epsilonRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by Fc epsilonRI+ non-B, non-T (NBNT) cells. th2 184-187 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 8-20 9257851-1 1997 The IgE/Fc epsilonRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by Fc epsilonRI+ non-B, non-T (NBNT) cells. th2 184-187 interleukin 4 Mus musculus 206-210 9257851-1 1997 The IgE/Fc epsilonRI interaction is postulated to play an important role in resistance to helminths both at the level of anti-parasitic effector cell function and in the initiation of Th2 responses through IL-4 produced by Fc epsilonRI+ non-B, non-T (NBNT) cells. th2 184-187 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 223-235 9233608-9 1997 The results with CBA/N B cells further suggest that the xid mutation selectively affects their capacity to respond to Th2-derived signals, for reasons that remain unclear. th2 118-121 Bruton agammaglobulinemia tyrosine kinase Mus musculus 56-59 9411594-17 1997 Desensitisation also shows that in spite of its complexity, one can reorientate towards a Th1 response based on spontaneous Th2 response. th2 124-127 negative elongation factor complex member C/D Homo sapiens 90-93 9175834-6 1997 These data suggest that interactions between the TCR, MHC II-peptide complex and CD4 may be involved in Th2 development. th2 104-107 T cell receptor alpha variable 6-3 Mus musculus 49-52 9175834-6 1997 These data suggest that interactions between the TCR, MHC II-peptide complex and CD4 may be involved in Th2 development. th2 104-107 CD4 antigen Mus musculus 81-84 9079802-4 1997 However, in mice deficient for CD28, Th2 responses are diminished, but not abrogated. th2 37-40 CD28 antigen Mus musculus 31-35 9289468-8 1996 The pregnancy induced possible Th2 prevalence so as role of such factors like PGE2, TGF2, 1.25-(OH)2-Vit. th2 31-34 vitrin Homo sapiens 101-104 33800208-6 2021 (3) Results: CerS2 null mice exhibited milder symptoms and lower Th2 responses than WT mice after OVA exposure. th2 65-68 ceramide synthase 2 Mus musculus 13-18 33800208-7 2021 CerS2 null CD4+ T cells showed impaired Th2 and increased Th17 responses with concomitant higher T cell receptor (TCR) signal strength after TCR stimulation. th2 40-43 ceramide synthase 2 Mus musculus 0-5 33800208-7 2021 CerS2 null CD4+ T cells showed impaired Th2 and increased Th17 responses with concomitant higher T cell receptor (TCR) signal strength after TCR stimulation. th2 40-43 CD4 antigen Mus musculus 11-14 33800208-10 2021 CerS2 and very-long chain SLs may be therapeutic targets for Th2-related diseases such as asthma. th2 61-64 ceramide synthase 2 Mus musculus 0-5 34492279-9 2022 Increased total n-3 PUFA (DHA, EPA and ALA) was significantly associated with lower IL-10 (beta = -0.667; p = 0.007) and lower total Th2 (IL-4, IL-10 and IL-13) (beta = -0.715; p = 0.036). th2 133-136 interleukin 4 Homo sapiens 138-142 34555704-4 2022 Upon oral challenge, FLN c triggered more severe anaphylactic symptoms, higher levels of specific antibodies and histamine in serum than TIM, while TIM was a more active promotor of early specific antibody production and stimulated stronger Th2-biased responses. th2 241-244 filamin C, gamma Mus musculus 21-26 34537772-15 2022 CONCLUSION: Linc00632 acted as a suppression factor in Th2 differentiation by inhibiting the expression of GATA-3 via interacting with EZH2, which might provide a new insight for understanding the action mechanism of Linc00632 in AR. th2 55-58 long intergenic non-protein coding RNA 632 Homo sapiens 12-21 34537772-15 2022 CONCLUSION: Linc00632 acted as a suppression factor in Th2 differentiation by inhibiting the expression of GATA-3 via interacting with EZH2, which might provide a new insight for understanding the action mechanism of Linc00632 in AR. th2 55-58 GATA binding protein 3 Homo sapiens 107-113 34862257-0 2022 HuR-Targeted Inhibition Impairs Th2 Proinflammatory Responses in Asthmatic CD4+ T Cells. th2 32-35 ELAV like RNA binding protein 1 Homo sapiens 0-3 34862257-0 2022 HuR-Targeted Inhibition Impairs Th2 Proinflammatory Responses in Asthmatic CD4+ T Cells. th2 32-35 CD4 molecule Homo sapiens 75-78 34580428-4 2022 In line with our previous finding of increased mitochondrial H2O2 production from lung DCs of mice tolerized to ovalbumin, depletion of mitochondrial H2O2 in MCAT mice abrogated HDM-induced airway tolerance (Tol) with elevated Th2 effector response, airway eosinophilia, and increased airway hyperreactivity. th2 227-230 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 112-121 34580428-4 2022 In line with our previous finding of increased mitochondrial H2O2 production from lung DCs of mice tolerized to ovalbumin, depletion of mitochondrial H2O2 in MCAT mice abrogated HDM-induced airway tolerance (Tol) with elevated Th2 effector response, airway eosinophilia, and increased airway hyperreactivity. th2 227-230 malonyl CoA:ACP acyltransferase (mitochondrial) Mus musculus 158-162 34992396-3 2021 IL-25 promotes development of a Th2 immune response and M2 macrophages that counteract the inflammation associated with obesity and T2D. th2 32-35 interleukin 25 Mus musculus 0-5 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 LOC105243590 Mus musculus 185-189 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 immunoglobulin heavy variable V1-9 Mus musculus 191-196 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 Immunoglobulin heavy constant gamma 3 Mus musculus 202-206 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 interleukin 4 Mus musculus 248-252 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 interleukin 5 Mus musculus 254-258 34992603-11 2021 The reduced parasite count and pathology in infected lungs were associated with strong Th2 immune responses characterized by the high titers of antigen-specific IgG and its subclasses (IgG1, IgG2a, and IgG3) in the sera and significantly increased IL-4, IL-5, IL-13 levels in lung tissues. th2 87-90 interleukin 13 Mus musculus 260-265 34882054-5 2022 While the overall immune cell phenotype was not affected profoundly upon treatment using Gastrin-MSCs or upon in vitro culture, pancreatic lymph node cells from Gastrin-MSC treated mice, upon ex vivo challenge with self-antigen, showed a Th2 and Th17 bias, and diminished the diabetogenic property in NOD-Rag1 deficient mice suggesting a disease protective immune modulation under Gastrin-MSC treatment associated protection from hyperglycaemia. th2 238-241 gastrin Mus musculus 161-168 34882054-5 2022 While the overall immune cell phenotype was not affected profoundly upon treatment using Gastrin-MSCs or upon in vitro culture, pancreatic lymph node cells from Gastrin-MSC treated mice, upon ex vivo challenge with self-antigen, showed a Th2 and Th17 bias, and diminished the diabetogenic property in NOD-Rag1 deficient mice suggesting a disease protective immune modulation under Gastrin-MSC treatment associated protection from hyperglycaemia. th2 238-241 gastrin Mus musculus 381-388 34943041-2 2021 The parasite regulates the host immune system by inducing a strong Th2 and regulatory T (Treg) cell immune response through mechanisms that might involve the expression or activity of heme-oxygenase-1 (HO-1), the rate-limiting enzyme in the catabolism of free heme that also has immunoregulatory and antioxidant properties. th2 67-70 heme oxygenase 1 Mus musculus 184-200 34943041-2 2021 The parasite regulates the host immune system by inducing a strong Th2 and regulatory T (Treg) cell immune response through mechanisms that might involve the expression or activity of heme-oxygenase-1 (HO-1), the rate-limiting enzyme in the catabolism of free heme that also has immunoregulatory and antioxidant properties. th2 67-70 heme oxygenase 1 Homo sapiens 202-206 34862127-0 2021 ILC2s induce adaptive Th2-type immunity in different stages of tuberculosis through the Notch-GATA3 pathway. th2 22-25 notch receptor 1 Homo sapiens 88-93 34732466-1 2021 Dendritic cells (DCs) are the most specialized APCs that play a critical role in driving Th2 differentiation, but the mechanism is not fully understood. th2 89-92 amyloid P component, serum Rattus norvegicus 47-51 34732466-3 2021 Mice with Vps33b-specific deletion in DCs, but not in macrophages or T cells, were more susceptible to Th2-mediated allergic lung inflammation than wild-type mice. th2 103-106 vacuolar protein sorting 33B Mus musculus 10-16 34732466-5 2021 Moreover, Vps33B specifically restrained reactive oxygen species production in conventional DC1s to inhibit Th2 responses in vitro, whereas Vps33B in monocyte-derived DCs and conventional DC2s was dispensable for Th2 development in asthma pathogenesis. th2 108-111 VPS33B, late endosome and lysosome associated Rattus norvegicus 10-16 34726583-0 2021 Polyphenol containing Sargassum horneri attenuated Th2 differentiation in splenocytes of ovalbumin-sensitised mice: involvement of the transcription factors GATA3/STAT5/NLRP3 in Th2 polarization. th2 51-54 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 89-98 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 55-58 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 GATA binding protein 3 Mus musculus 75-80 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 NLR family, pyrin domain containing 3 Mus musculus 86-91 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 interleukin 4 Mus musculus 102-106 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 interleukin 5 Mus musculus 108-112 34726583-12 2021 CONCLUSIONS: SHE exhibits Th2 immune suppression under OVA stimulation via GATA3- and NLRP3-dependent IL-4, IL-5, and IL-13 suppression. th2 26-29 interleukin 13 Mus musculus 118-123 34944573-5 2021 In vitro, VitD3-tolDC treatment reduced the percentage of activated T cells and allogeneic proliferation, whereas VitD3-tolDC+IFN-beta treatment enhanced the suppressive ability of VitD3-tolDC and, additionally, induced a shift towards a Th2 profile. th2 238-241 IFN1@ Homo sapiens 126-134 34764345-5 2021 In contrast, Th2/Treg related pathways were upregulated as shown by higher expression of IL4 and TGF-beta family genes. th2 13-16 interleukin 4 Mus musculus 89-92 34343404-9 2021 These observations indicated that M. gallisepticum may have suppressed Th2 responses by upregulating secretion of IFN-gamma and IL-17 by CD4+ cells and induced immune dysregulation characterised by depletion of CD8+ cells and downregulation of IL-2 in the tracheas of unvaccinated birds. th2 71-74 interferon gamma Gallus gallus 114-123 34343404-9 2021 These observations indicated that M. gallisepticum may have suppressed Th2 responses by upregulating secretion of IFN-gamma and IL-17 by CD4+ cells and induced immune dysregulation characterised by depletion of CD8+ cells and downregulation of IL-2 in the tracheas of unvaccinated birds. th2 71-74 interleukin 17A Gallus gallus 128-133 34343404-9 2021 These observations indicated that M. gallisepticum may have suppressed Th2 responses by upregulating secretion of IFN-gamma and IL-17 by CD4+ cells and induced immune dysregulation characterised by depletion of CD8+ cells and downregulation of IL-2 in the tracheas of unvaccinated birds. th2 71-74 T-cell surface glycoprotein CD4 Gallus gallus 137-140 34523252-7 2021 Pathway enrichment analysis suggested that TREM2 activation may be associated with Th2-related pathways. th2 83-86 triggering receptor expressed on myeloid cells 2 Homo sapiens 43-48 34790195-3 2021 In the absence of Nlrx1, hosts produce an enhanced Th2 response primarily by CD103+ dendritic cell populations resulting in enhanced mortality via immunopathogenesis as well as enhanced fungal burden. th2 51-54 NLR family member X1 Homo sapiens 18-23 34744439-2 2021 YKL-40 is a pivotal pro-inflammatory mediator to promote Th2 immune response which is involved in many inflammatory diseases. th2 57-60 chitinase 3 like 1 Homo sapiens 0-6 34707103-8 2021 Consistently, metastasis is greatly enhanced in Th2-skewing T-bet-deficient mice or in nude mice adoptively transferred with T-bet-deficient T cells. th2 48-51 T-box 21 Mus musculus 60-65 34667722-10 2021 CONCLUSION: TSLP induces a Th2 immune response and promots Th2 T cell differentiation in vivo. th2 27-30 thymic stromal lymphopoietin Mus musculus 12-16 34658046-3 2022 The present study aimed at characterizing distinct FoxP3+ Treg subpopulations involved in the suppression of Th2-mediated allergic inflammation in the lung. th2 109-112 forkhead box P3 Mus musculus 51-56 34658046-6 2022 RESULTS: We found that during resolution of allergic airway inflammation in mice >50% of FoxP3+ Treg cells expressed the integrin CD103 which marks FoxP3+ Treg cells of high IL-10 production, increased expression of immunoregulatory molecules such as KLRG1, ICOS and CD127, and enhanced suppressive capacity for Th2-mediated inflammatory responses. th2 312-315 forkhead box P3 Mus musculus 89-94 34658046-6 2022 RESULTS: We found that during resolution of allergic airway inflammation in mice >50% of FoxP3+ Treg cells expressed the integrin CD103 which marks FoxP3+ Treg cells of high IL-10 production, increased expression of immunoregulatory molecules such as KLRG1, ICOS and CD127, and enhanced suppressive capacity for Th2-mediated inflammatory responses. th2 312-315 integrin alpha E, epithelial-associated Mus musculus 130-135 34658046-8 2022 Conversely, adoptive transfer of CD103+ FoxP3+ Tregs effectively treated disease, attenuating Th2 responses and allergic inflammation in an IL-10-dependent manner. th2 94-97 integrin alpha E, epithelial-associated Mus musculus 33-38 34658046-8 2022 Conversely, adoptive transfer of CD103+ FoxP3+ Tregs effectively treated disease, attenuating Th2 responses and allergic inflammation in an IL-10-dependent manner. th2 94-97 forkhead box P3 Mus musculus 40-45 34642338-5 2021 We elucidate the dual role of IL-31 in SSc, where IL-31 directly promotes collagen production in DFs and indirectly enhances Th2 immune responses by increasing pro-Th2 cytokine expression in DFs. th2 125-128 interleukin 31 Homo sapiens 30-35 34642338-5 2021 We elucidate the dual role of IL-31 in SSc, where IL-31 directly promotes collagen production in DFs and indirectly enhances Th2 immune responses by increasing pro-Th2 cytokine expression in DFs. th2 125-128 interleukin 31 Homo sapiens 50-55 34609751-0 2022 IL2-inducible T-cell kinase inhibitor ibrutinib reduces symptoms and Th2 differentiation in mouse allergic-rhinitis model. th2 69-72 IL2 inducible T cell kinase Mus musculus 0-27 34609751-2 2022 Targeting Th2 and Th17 response has been shown to ameliorate AR. th2 10-13 ferredoxin reductase Mus musculus 61-63 34709764-6 2021 Diminished CXCR4+ dNK cells and their impaired ability to induce Th2 differentiation were found in RM patients and mouse models of spontaneous abortion. th2 65-68 C-X-C motif chemokine receptor 4 Homo sapiens 11-16 34709764-6 2021 Diminished CXCR4+ dNK cells and their impaired ability to induce Th2 differentiation were found in RM patients and mouse models of spontaneous abortion. th2 65-68 deoxyribonucleoside kinase Drosophila melanogaster 18-21 34315114-4 2021 We show that anti-F4/80 treatment alleviates Th2 cell responses in mice immunized and challenged with OVA or house dust mite (HDM). th2 45-48 adhesion G protein-coupled receptor E1 Mus musculus 18-23 34630778-12 2021 Conclusion: LJZD improved OVA-induced asthma in Balb/C mice by inhibiting allergic inflammation and Th2 immunoreaction, which might be associated with the inactivation of the NF-kappaB signaling pathway. th2 100-103 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 26-29 34638904-2 2021 Interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) axis is known to drive TH2 response, while its effect on GAS infection is unclear. th2 84-87 interleukin 33 Mus musculus 16-21 34638904-2 2021 Interleukin-33 (IL-33)/suppression of tumorigenicity 2 (ST2) axis is known to drive TH2 response, while its effect on GAS infection is unclear. th2 84-87 interleukin 1 receptor-like 1 Mus musculus 56-59 34580195-7 2022 RESULTS: PC3 was associated with baseline Th2 clinical features including blood (rank-sum p=0.0082) and airway (rank-sum p=0.0024) eosinophilia, FEV1 change (Kendall tau-b R=-0.333 (-0.592 to -0.012)) and follow-up FEV1 albuterol response (Kendall tau-b R=0.392 (0.079 to 0.634)). th2 42-45 proprotein convertase subtilisin/kexin type 1 Homo sapiens 9-12 34595240-15 2021 In OVA-stimulated splenocyte cultures, a significant reduction of IL-5 and IL-13 in DCT-treated mice suggests that DCT may alleviate Th2 responses. th2 133-136 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 3-6 34232708-8 2021 Conclusions: In addition to finding a significant limitation of IGRA testing severely ill COVID-19 patients, these data provide evidence that many of these patients demonstrate a focused Th2 immune response with inhibition of IFN-gamma signaling and, in many cases, significant elevations of IL-6. th2 187-190 interferon gamma Homo sapiens 226-235 34580637-14 2021 These findings indicate that an increase in IL-4+ CD4+ T cells in the LLN and splenocyte resulted in increased Th2 response to AE exposure. th2 111-114 interleukin 4 Mus musculus 44-48 34580637-14 2021 These findings indicate that an increase in IL-4+ CD4+ T cells in the LLN and splenocyte resulted in increased Th2 response to AE exposure. th2 111-114 CD4 antigen Mus musculus 50-53 34580637-15 2021 Exposure of the respiratory system to AE resulted in an increased allergen-induced Th2 inflammatory response and AHR through accumulation of inflammatory and IL-4+ CD4+ T cells and collagen deposition. th2 83-86 interleukin 4 Mus musculus 158-162 34580637-15 2021 Exposure of the respiratory system to AE resulted in an increased allergen-induced Th2 inflammatory response and AHR through accumulation of inflammatory and IL-4+ CD4+ T cells and collagen deposition. th2 83-86 CD4 antigen Mus musculus 164-167 34506849-14 2022 CONCLUSION: Absence of Taok3 or loss of its kinase activity protects from HDM-driven allergic asthma due to defects in both adaptive DC-mediated Th2 activation and innate ILC2 function. th2 145-148 TAO kinase 3 Mus musculus 23-28 34475490-8 2021 There are no statistical differences in nearly all inflammatory markers when compared to their infection-naive CF counterparts, except in the Th2-derived IL-4 and IL-5 which demonstrate significant decreases following exposure (p = 0.046, p = 0.045). th2 142-145 interleukin 4 Mus musculus 154-158 34475490-8 2021 There are no statistical differences in nearly all inflammatory markers when compared to their infection-naive CF counterparts, except in the Th2-derived IL-4 and IL-5 which demonstrate significant decreases following exposure (p = 0.046, p = 0.045). th2 142-145 interleukin 5 Mus musculus 163-167 34448417-7 2021 These results suggest that SO2 amplifies Th2-mediated inflammatory responses, which involve reactive oxygen species and TLR4/NF-kappaB pathway activation; these can further enhance Th2 cytokine expression and eosinophilic inflammation. th2 41-44 toll-like receptor 4 Mus musculus 120-124 34448417-7 2021 These results suggest that SO2 amplifies Th2-mediated inflammatory responses, which involve reactive oxygen species and TLR4/NF-kappaB pathway activation; these can further enhance Th2 cytokine expression and eosinophilic inflammation. th2 41-44 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 125-134 34460865-10 2021 By stimulating the release of IL-33, alum induced Th2 immunity via IL-5 and IL-13 production in group 2 innate lymphoid cells (ILC2s) and increased MHC class II expression in antigen-presenting cells (APCs) in the lung. th2 50-53 interleukin 33 Mus musculus 30-35 34460865-10 2021 By stimulating the release of IL-33, alum induced Th2 immunity via IL-5 and IL-13 production in group 2 innate lymphoid cells (ILC2s) and increased MHC class II expression in antigen-presenting cells (APCs) in the lung. th2 50-53 interleukin 5 Mus musculus 67-71 34460865-10 2021 By stimulating the release of IL-33, alum induced Th2 immunity via IL-5 and IL-13 production in group 2 innate lymphoid cells (ILC2s) and increased MHC class II expression in antigen-presenting cells (APCs) in the lung. th2 50-53 interleukin 13 Mus musculus 76-81 34413303-7 2021 By contrast, CD200+ mature cDC2 strongly induce Th2, but not Th17, differentiation. th2 48-51 CD200 molecule Homo sapiens 13-18 34413303-7 2021 By contrast, CD200+ mature cDC2 strongly induce Th2, but not Th17, differentiation. th2 48-51 cyclin dependent kinase 1 Homo sapiens 27-31 34484176-0 2021 The Pathogenesis of Eosinophilic Asthma: A Positive Feedback Mechanism That Promotes Th2 Immune Response via Filaggrin Deficiency. th2 85-88 filaggrin Homo sapiens 109-118 34456917-12 2021 In the Th2-polarized environment characteristic of allergic asthma, high levels of IL-4 produced by locally infiltrating innate lymphoid cells and helper T cells promote the acquisition of an alternatively activated M2a phenotype in macrophages, with myriad effects on the local immune response and airway structure. th2 7-10 interleukin 4 Homo sapiens 83-87 34442794-13 2021 This study shows that the recombinant miRNA that expresses the TLR8 miRNA has therapeutic effects by suppressing Th2 inflammation. th2 113-116 toll-like receptor 8 Mus musculus 63-67 34116562-9 2021 Moreover, THC-FMT showed better preventive effects than Cur-FMT on the development of allergic inflammation in OVA-induced mice, resulting in a reduction in symptoms and Th2-mediated inflammation in both lung and colon tissues. th2 170-173 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 111-114 34189964-2 2021 We have shown previously that insulin receptor substrate 2 (IRS2), a molecule highly critical to insulin resistance and metabolism, has an anti-inflammatory role in Th2-skewed lung inflammation and pulmonary vascular remodeling. th2 165-168 insulin receptor substrate 2 Mus musculus 30-58 34189964-2 2021 We have shown previously that insulin receptor substrate 2 (IRS2), a molecule highly critical to insulin resistance and metabolism, has an anti-inflammatory role in Th2-skewed lung inflammation and pulmonary vascular remodeling. th2 165-168 insulin receptor substrate 2 Mus musculus 60-64 34131922-3 2021 As a key regulator of Th2 responses, IL-33/ST2 signal is primarily associated with immunity and immune-related disorders. th2 22-25 interleukin 33 Homo sapiens 37-42 34131922-3 2021 As a key regulator of Th2 responses, IL-33/ST2 signal is primarily associated with immunity and immune-related disorders. th2 22-25 ST2 Homo sapiens 43-46 34329367-8 2021 Further, this independence is maintained even when the mice are treated with an anti-IFNgamma antibody during infection to create a strongly polarised Th2 environment. th2 151-154 interferon gamma Mus musculus 85-93 34324507-3 2021 Studies have indicated that Th2 response is the main immune defense mechanism against toxocariasis, however, there are still few studies related to this response, mainly the IL-33/ST2 pathway. th2 28-31 interleukin 33 Mus musculus 174-179 34324507-3 2021 Studies have indicated that Th2 response is the main immune defense mechanism against toxocariasis, however, there are still few studies related to this response, mainly the IL-33/ST2 pathway. th2 28-31 interleukin 1 receptor-like 1 Mus musculus 180-183 34324507-5 2021 By binding to its ST2 receptor, IL-33 stimulating the Th2 polarized immune cell and cytokine responses. th2 54-57 interleukin 33 Mus musculus 32-37 34324507-9 2021 Collectively, our results demonstrate that the Th2 immune response triggered by IL-33/ST2 pathway mediates susceptibility to T. canis, related to parasitic burden, eosinophilia and granuloma formation in which consequently contributes to tissue inflammation and injury. th2 47-50 interleukin 33 Mus musculus 80-85 34324507-9 2021 Collectively, our results demonstrate that the Th2 immune response triggered by IL-33/ST2 pathway mediates susceptibility to T. canis, related to parasitic burden, eosinophilia and granuloma formation in which consequently contributes to tissue inflammation and injury. th2 47-50 interleukin 1 receptor-like 1 Mus musculus 86-89 34301307-2 2021 TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response. th2 141-144 thymic stromal lymphopoietin Homo sapiens 0-4 34301307-2 2021 TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response. th2 141-144 interleukin 25 Homo sapiens 6-11 34301307-2 2021 TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response. th2 141-144 interleukin 33 Homo sapiens 16-21 34360618-10 2021 In contrast, inhibitors of TMEM16A may suppress pulmonary Th2 inflammation, goblet cell metaplasia, mucus production, and bronchoconstriction, partially by inhibiting expression of SPDEF. th2 58-61 anoctamin 1 Homo sapiens 27-34 34265409-13 2021 CONCLUSIONS: Targeting Th2-related molecules, in particular IL-4, holds promise for EDHM management. th2 23-26 interleukin 4 Homo sapiens 60-64 34244314-2 2021 Previously, we uncovered a lung TNFR2+ conventional DC2 subset (cDC2s) that induces regulatory T cells (Tregs) maintaining lung tolerance at steady state but promotes TH2 response during house dust mite (HDM)-induced asthma. th2 167-170 TNF receptor superfamily member 1B Homo sapiens 32-37 34244314-2 2021 Previously, we uncovered a lung TNFR2+ conventional DC2 subset (cDC2s) that induces regulatory T cells (Tregs) maintaining lung tolerance at steady state but promotes TH2 response during house dust mite (HDM)-induced asthma. th2 167-170 monoacylglycerol O-acyltransferase 1 Homo sapiens 52-55 34244314-4 2021 Here, we showed that exogenous IFNbeta reprogrammed TH2-promoting pathogenic TNFR2+ cDC2s back to tolerogenic DCs, alleviating eosinophilic asthma and preventing asthma exacerbation. th2 52-55 interferon alpha 1 Homo sapiens 31-38 34244314-4 2021 Here, we showed that exogenous IFNbeta reprogrammed TH2-promoting pathogenic TNFR2+ cDC2s back to tolerogenic DCs, alleviating eosinophilic asthma and preventing asthma exacerbation. th2 52-55 TNF receptor superfamily member 1B Homo sapiens 77-82 34305908-0 2021 Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. th2 31-34 C-type lectin domain containing 7A Homo sapiens 0-8 34305908-0 2021 Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. th2 31-34 thymic stromal lymphopoietin Homo sapiens 18-22 34305908-0 2021 Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. th2 31-34 signal transducer and activator of transcription 3 Homo sapiens 58-63 34305908-0 2021 Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. th2 31-34 signal transducer and activator of transcription 6 Homo sapiens 65-70 34305908-0 2021 Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. th2 31-34 CD40 molecule Homo sapiens 76-79 34305908-0 2021 Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells. th2 31-34 RELB proto-oncogene, NF-kB subunit Homo sapiens 80-84 34358159-3 2021 In contrast, type 1 adjuvants like CpG-ODN, a synthetic toll-like receptor 9 agonist, inhibit the development of Th2 immunity. th2 113-116 toll-like receptor 9 Mus musculus 56-76 34276650-2 2021 Immunopathological mechanisms are well established in the L. (L.) major-mouse model, in which IL-4 instructs a Th2 response towards progressive infection. th2 111-114 interleukin 4 Mus musculus 94-98 34220330-14 2021 Conclusion: Th2 immune response can be involved in the activation of mast cells in POI, which was associated with ROS mediated activation of NF-kappaB and p38 MAPK signaling pathway. th2 12-15 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 141-150 34220330-14 2021 Conclusion: Th2 immune response can be involved in the activation of mast cells in POI, which was associated with ROS mediated activation of NF-kappaB and p38 MAPK signaling pathway. th2 12-15 mitogen-activated protein kinase 14 Mus musculus 155-163 34208504-8 2021 Although Gly m 4 was shown to be susceptible to gastrointestinal enzymes, some of its proteolytic fragments can selectively cross the epithelial barrier and induce production of Th2-polarizing IL-5, IL-10, and IL-13, which may point at the presence of the T-cell epitope among the crossed fragments. th2 178-181 interleukin 5 Homo sapiens 193-197 34126986-3 2021 The goal of this study was to unveil the function of SERPINB10 in the Th2 response of allergic asthma and the mechanism by which SERPINB10 affects the viability of Th2 cells. th2 70-73 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Mus musculus 53-62 34126986-3 2021 The goal of this study was to unveil the function of SERPINB10 in the Th2 response of allergic asthma and the mechanism by which SERPINB10 affects the viability of Th2 cells. th2 70-73 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Mus musculus 129-138 34126986-14 2021 CONCLUSION: Our results suggest that SERPINB10 may contribute to allergic inflammation and the Th2 response of asthma by inhibiting the apoptosis of Th2 cells. th2 95-98 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 Mus musculus 37-46 34221208-2 2021 MicroRNA-155 (miRNA-155) has an essential role in regulating gene expression and can mediate the allergic TH2 process. th2 106-109 microRNA 155 Homo sapiens 0-12 34221208-2 2021 MicroRNA-155 (miRNA-155) has an essential role in regulating gene expression and can mediate the allergic TH2 process. th2 106-109 microRNA 155 Homo sapiens 14-23 34198852-4 2021 ACE2 receptor downregulation occurred specifically in females in Th2 high asthma, while proteases broadly assisting coronavirus and influenza viral entry, TMPRSS2, and TMPRSS4, were highly upregulated in both sexes. th2 65-68 angiotensin converting enzyme 2 Homo sapiens 0-4 34082780-13 2021 CONCLUSIONS: Immunization with rEg.P29 downregulated the expression of lncRNA028466, which was related to a higher Th1 immune response and a lower Th2 immune response. th2 147-150 regenerating family member 1 alpha Rattus norvegicus 31-34 34082780-13 2021 CONCLUSIONS: Immunization with rEg.P29 downregulated the expression of lncRNA028466, which was related to a higher Th1 immune response and a lower Th2 immune response. th2 147-150 SYF2 homolog, RNA splicing factor (S. cerevisiae) Mus musculus 35-38 34185416-6 2021 Concordantly, compared to wild-type (wt) mice, Mir146a/b-/- mice exhibited more severe airway neutrophilia and increased T helper (Th)1 and Th17 cell infiltration in response to RV-A1b infection and a stronger Th17 response with a less prominent Th2 response in house dust mite extract (HDM)-induced allergic airway inflammation and RV-induced exacerbation models. th2 246-249 microRNA 146 Mus musculus 47-56 34122398-2 2021 Newborns are relatively deficient in ADA1 resulting in elevated plasma adenosine concentrations and a Th2/anti-inflammatory bias compared to adults. th2 102-105 transcriptional adaptor 1 Homo sapiens 37-41 34810089-4 2021 On the other hand, CD40 and CD154 are necessary for induction of most Th2 responses. th2 70-73 CD40 molecule Homo sapiens 19-23 34810089-4 2021 On the other hand, CD40 and CD154 are necessary for induction of most Th2 responses. th2 70-73 CD40 ligand Homo sapiens 28-33 34810089-5 2021 We attempt to reconcile these observations, mainly by proposing that (i) CD40 up-regulation in DC in Th2 systems is mostly induced by alarmins, (ii) the Th2 to Th1 shift induced by exogenous CD40 ligation is related to the capacity of such ligation to enhance IL-12 production by myeloid cells, and (iii) signals elicited by endogenous CD154 available in Th2 contexts and by exogenous CD40 ligation are probably different. th2 101-104 CD40 molecule Homo sapiens 73-77 34810089-5 2021 We attempt to reconcile these observations, mainly by proposing that (i) CD40 up-regulation in DC in Th2 systems is mostly induced by alarmins, (ii) the Th2 to Th1 shift induced by exogenous CD40 ligation is related to the capacity of such ligation to enhance IL-12 production by myeloid cells, and (iii) signals elicited by endogenous CD154 available in Th2 contexts and by exogenous CD40 ligation are probably different. th2 101-104 CD40 molecule Homo sapiens 191-195 34810089-5 2021 We attempt to reconcile these observations, mainly by proposing that (i) CD40 up-regulation in DC in Th2 systems is mostly induced by alarmins, (ii) the Th2 to Th1 shift induced by exogenous CD40 ligation is related to the capacity of such ligation to enhance IL-12 production by myeloid cells, and (iii) signals elicited by endogenous CD154 available in Th2 contexts and by exogenous CD40 ligation are probably different. th2 101-104 CD40 ligand Homo sapiens 336-341 34810089-5 2021 We attempt to reconcile these observations, mainly by proposing that (i) CD40 up-regulation in DC in Th2 systems is mostly induced by alarmins, (ii) the Th2 to Th1 shift induced by exogenous CD40 ligation is related to the capacity of such ligation to enhance IL-12 production by myeloid cells, and (iii) signals elicited by endogenous CD154 available in Th2 contexts and by exogenous CD40 ligation are probably different. th2 101-104 CD40 molecule Homo sapiens 385-389 34810089-8 2021 Finally, we argue that CD154 is a general immune activation signal across immune polarization including Th2, and propose that competition for CD154 at tissue sites may provide negative feedback on response induction at each site. th2 104-107 CD40 ligand Homo sapiens 23-28 34810089-8 2021 Finally, we argue that CD154 is a general immune activation signal across immune polarization including Th2, and propose that competition for CD154 at tissue sites may provide negative feedback on response induction at each site. th2 104-107 CD40 ligand Homo sapiens 142-147 34796003-1 2021 The involvement of periostin in Th2-dependent allergic inflammation has been documented. th2 32-35 periostin Homo sapiens 19-28 35278445-11 2022 Elevated serum periostin levels were positively associated with serum levels of Th2 mediators, such as interleukin (IL)-4, IL-5, IL-13, and eotaxin. th2 80-83 periostin Homo sapiens 15-24 35278445-11 2022 Elevated serum periostin levels were positively associated with serum levels of Th2 mediators, such as interleukin (IL)-4, IL-5, IL-13, and eotaxin. th2 80-83 interleukin 4 Homo sapiens 103-121 35278445-11 2022 Elevated serum periostin levels were positively associated with serum levels of Th2 mediators, such as interleukin (IL)-4, IL-5, IL-13, and eotaxin. th2 80-83 C-C motif chemokine ligand 11 Homo sapiens 140-147 35278445-14 2022 Thus, the results suggested that periostin may be involved in the arsenic-related pathogenesis of Th2-mediated asthma. th2 98-101 periostin Homo sapiens 33-42 34999930-11 2022 Subsequently, Naticol Gut delivery modulated CD4 T cells in favor of a Th2 response and dampened CD8 T-cell activation. th2 71-74 CD4 antigen Mus musculus 45-48 35514302-0 2022 Interleukin-27 ameliorates allergic asthma by alleviating the lung Th2 inflammatory environment. th2 67-70 interleukin 27 Mus musculus 0-14 35514302-10 2022 Taken together, these findings demonstrate that the prophylactic administration of IL-27 ameliorates asthma by alleviating the lung Th2 inflammatory environment through the restoration of both the STAT1 and STAT3 pathways. th2 132-135 interleukin 27 Mus musculus 83-88 35514302-10 2022 Taken together, these findings demonstrate that the prophylactic administration of IL-27 ameliorates asthma by alleviating the lung Th2 inflammatory environment through the restoration of both the STAT1 and STAT3 pathways. th2 132-135 signal transducer and activator of transcription 1 Mus musculus 197-202 35514302-10 2022 Taken together, these findings demonstrate that the prophylactic administration of IL-27 ameliorates asthma by alleviating the lung Th2 inflammatory environment through the restoration of both the STAT1 and STAT3 pathways. th2 132-135 signal transducer and activator of transcription 3 Mus musculus 207-212 35397798-14 2022 Individuals with COVID-19 who clinically deteriorated (ie, who met the primary outcome) showed an early blunted respiratory interferon response and pronounced and persistent Th2 inflammation, mediated by CC chemokine ligand (CCL)-24, compared with those with COVID-19 who did not clinically deteriorate. th2 174-177 C-C motif chemokine ligand 24 Homo sapiens 204-232 35447485-9 2022 The distinct metabolic phenotype and associated gene expression in activated CD4+ T cells may be intrinsic drivers of the Th2-biased response by young calves. th2 122-125 CD4 molecule Bos taurus 77-80 35447485-10 2022 Additionally, CD4+ recent thymic emigrant cells (RTEs) may further contribute to altered effector function, as they are preferential precursors to Tregs, and based on the microenvironment, have the propensity to polarize toward Th2. th2 228-231 CD4 molecule Bos taurus 14-17 35612500-0 2022 Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects. th2 53-56 hematopoietic prostaglandin D synthase Homo sapiens 0-39 35596832-5 2022 The presence of Nr1d1 also imparts protection against associated inflammatory responses in murine model of asthma and its ligand SR9011 eased disease severity by suppressing Th2 responses. th2 174-177 nuclear receptor subfamily 1, group D, member 1 Mus musculus 16-21 35596832-6 2022 Moreover, Chip-seq profiling uncovered Nr1d1 interactions with other gene subsets that impedes Th2-linked pathways and regulates metabolism, immunity and brain functions, therefore, providing empirical evidence regarding the genetic link between asthma and other comorbid conditions. th2 95-98 nuclear receptor subfamily 1, group D, member 1 Mus musculus 39-44 35589717-5 2022 Mice lacking Cul5 in T cells develop Th2 and Th9 inflammation and show pathophysiological features of atopic asthma. th2 37-40 cullin 5 Mus musculus 13-17 35550500-0 2022 Tim-3+ decidual Mphis induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132. th2 30-33 hepatitis A virus cellular receptor 2 Mus musculus 0-5 35550500-0 2022 Tim-3+ decidual Mphis induced Th2 and Treg bias in decidual CD4+T cells and promoted pregnancy maintenance via CD132. th2 30-33 CD4 antigen Mus musculus 60-63 35551270-3 2022 p38alpha-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation. th2 77-80 mitogen-activated protein kinase 14 Homo sapiens 0-8 35600943-19 2022 In addition, Majie cataplasm can promote the quantity of NKs and the content of IL-1alpha and IFN-gamma, induce IFN-gamma +NKs to shut down the Th2 response, and tend to elicit the Th1 response. th2 144-147 interferon gamma Mus musculus 112-121 35615348-16 2022 Conclusion: Our data identify a novel role of IL-25 in enhancing eosinophils antigen uptake and co-stimulator molecules expression to induce Th2 priming in the context of allergic inflammation. th2 141-144 interleukin 25 Mus musculus 46-51 35503474-0 2022 ADAMTS7 Attenuates House Dust Mite-Induced Airway Inflammation and Th2 Immune Responses. th2 67-70 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 Mus musculus 0-7 35503474-8 2022 We propose that the mechanism by which ADAMTS7 negatively regulates DC function involves attenuated antigen uptake and presentation capabilities, which reduces allergic sensitization and Th2 immune responses in the lung. th2 187-190 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 Mus musculus 39-46 35503474-9 2022 CONCLUSION: In aggregate, we provide compelling evidence that ADAMTS7 plays a pivotal role in allergic airway disease and Th2 immunity and would be an attractive target for asthma. th2 122-125 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7 Mus musculus 62-69 35490426-4 2022 We found that, in contrast to SHN2, SHN3 is critical for IL-4 production and Th2 polarization. th2 77-80 HIVEP zinc finger 3 Homo sapiens 36-40 35490426-8 2022 Together, these findings uncover SHN3 as a novel, critical regulator of Th2 development. th2 72-75 HIVEP zinc finger 3 Homo sapiens 33-37 35449211-11 2022 Altogether, We have revealed a new pathway (PGRN-EZH2-PLZF), which regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment. th2 81-84 granulin Mus musculus 44-48 35449211-11 2022 Altogether, We have revealed a new pathway (PGRN-EZH2-PLZF), which regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment. th2 81-84 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 49-53 35449211-11 2022 Altogether, We have revealed a new pathway (PGRN-EZH2-PLZF), which regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment. th2 81-84 zinc finger and BTB domain containing 16 Mus musculus 54-58 35436743-14 2022 CONCLUSION: these findings indicate that IL-36beta enhances the pathology of DSS-induced colitis in mice by promoting Th2 responses in LPL while decreasing Foxp3+ Treg responses. th2 118-121 interleukin 36A Mus musculus 41-50 35239513-8 2022 The coordinated virus induction of MUC5AC and MUC5B suggests that non-Th2 mechanisms trigger mucin hypersecretion during exacerbations. th2 70-73 mucin 5, subtypes A and C, tracheobronchial/gastric Mus musculus 35-41 35428872-0 2022 Tissue-based IL-10 signalling in helminth infection limits IFNgamma expression and promotes the intestinal Th2 response. th2 107-110 interleukin 10 Mus musculus 13-18 35415925-0 2022 Mesenchymal stromal cells-derived small extracellular vesicles modulate DC function to suppress Th2 responses via IL-10 in patients with allergic rhinitis. th2 96-99 interleukin 10 Homo sapiens 114-119 34601735-9 2022 CONCLUSIONS: We demonstrate that FBP1 contains immunodominant peptides that induce a specific pro-inflammatory T helper cell response with increased Th2 levels that can drive an allergic inflammation in sensitized AD patients. th2 149-152 fructose-bisphosphatase 1 Homo sapiens 33-37 35341735-7 2022 Mice that lacked ST2 specifically on Tregs (Foxp3Cre,ST2flox/flox) demonstrated significantly worse skin fibrosis, increased Th2/Treg ratio and IL-13 expression in the skin compared with WT animals. th2 125-128 interleukin 1 receptor-like 1 Mus musculus 17-20 35372587-5 2022 High expression of GATA-3 accompanied by low expression of T-bet indicates predominance of Th2 response. th2 91-94 GATA binding protein 3 Homo sapiens 19-25 35372587-5 2022 High expression of GATA-3 accompanied by low expression of T-bet indicates predominance of Th2 response. th2 91-94 T-box transcription factor 21 Homo sapiens 59-64 35408882-7 2022 Combined IL-6/TNF inhibition, but not individual blockade of these two cytokines, led to complex anti-inflammatory effects including reduced Th2-induced eosinophilia and less prominent Th17/Th1-mediated neutrophilic infiltrate in the airways. th2 141-144 interleukin 6 Mus musculus 9-13 35408882-7 2022 Combined IL-6/TNF inhibition, but not individual blockade of these two cytokines, led to complex anti-inflammatory effects including reduced Th2-induced eosinophilia and less prominent Th17/Th1-mediated neutrophilic infiltrate in the airways. th2 141-144 tumor necrosis factor Mus musculus 14-17 35387344-6 2022 Treatment of DCs that drive enhanced Th2 immunity with a PDE4B inhibitor ameliorated DC-induced helper T cell response. th2 37-40 phosphodiesterase 4B, cAMP specific Mus musculus 57-62 35387344-7 2022 We conclude that PDE4B is a homeostatic regulator of cellular cAMP concentrations in DCs and may be a target for treating Th2-allergic asthma and other settings with low cellular cAMP concentrations. th2 122-125 phosphodiesterase 4B, cAMP specific Mus musculus 17-22 35296169-1 2022 BACKGROUND: Thymus and activation-regulated chemokine (TARC), which induces a Th2-dominated inflammation, is a well-known biomarker that reflects the severity of atopic dermatitis. th2 78-81 C-C motif chemokine ligand 17 Homo sapiens 12-53 35296169-1 2022 BACKGROUND: Thymus and activation-regulated chemokine (TARC), which induces a Th2-dominated inflammation, is a well-known biomarker that reflects the severity of atopic dermatitis. th2 78-81 C-C motif chemokine ligand 17 Homo sapiens 55-59 35359977-8 2022 Hence, B cell IL-4 is a major driver of Th2 responses in vivo which promotes allograft survival, and conversely, worsens AAD. th2 40-43 interleukin 4 Mus musculus 14-18 35313725-0 2022 Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response. th2 26-29 BTB domain and CNC homolog 2 Homo sapiens 0-5 35313725-7 2022 Furthermore, studies in various animal models show that Bach2 knockout animals spontaneously develop Th2 inflammation in the airway and gastrointestinal tract. th2 101-104 BTB domain and CNC homolog 2 Homo sapiens 56-61 35085518-8 2022 Moreover, administration of 5 mg/kg of Sch B alleviated the cardinal features of Th2-mediated allergic asthma, namely, serum OVA-specific IgE production, the development of airway hyperresponsiveness (AHR), and airway inflammation. th2 81-84 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 125-128 35196657-3 2022 OBJECTIVE: This study aims to explore the relationship of MCP1 protein expression in induced sputum with Th2 inflammation and asthma clinical features. th2 105-108 C-C motif chemokine ligand 2 Homo sapiens 58-62 35196657-4 2022 METHODS: MCP1 protein expression in induced sputum and serum was detected by ELISA in patients with asthma, and its correlation with Th2 inflammation and lung function was analyzed. th2 133-136 C-C motif chemokine ligand 2 Homo sapiens 9-13 35167596-6 2022 Th2- associated mediators, including arginase, IL-4, and IL-10 are downregulated, while cellular responses are upregulated in line with an increase in the levels of nitric oxide (NO) and interfero-gamma (IFN-gamma). th2 0-3 interleukin 4 Mus musculus 47-51 35167596-6 2022 Th2- associated mediators, including arginase, IL-4, and IL-10 are downregulated, while cellular responses are upregulated in line with an increase in the levels of nitric oxide (NO) and interfero-gamma (IFN-gamma). th2 0-3 interleukin 10 Mus musculus 57-62 35167596-6 2022 Th2- associated mediators, including arginase, IL-4, and IL-10 are downregulated, while cellular responses are upregulated in line with an increase in the levels of nitric oxide (NO) and interfero-gamma (IFN-gamma). th2 0-3 interferon gamma Mus musculus 204-213 35140475-7 2022 PTPRH increased in the house dust mite (HDM)-induced asthmatic mice, while Th2 airway inflammation and Muc5ac suppressed when treated with PTPRH. th2 75-78 protein tyrosine phosphatase, receptor type, H Mus musculus 139-144 35280367-11 2022 In addition, we found that PCGF1 expression was positively associated with the abundance of Th2, but negatively associated with T follicular helper, T central memory, and T gamma delta cells. th2 92-95 polycomb group ring finger 1 Homo sapiens 27-32 35140898-0 2022 Punicalagin Alleviates Aged Bronchial Asthma by Inhibiting Th2 Differentiation through IL-4/STAT6 and Jagged1/Notch Pathways. th2 59-62 interleukin 4 Homo sapiens 87-91 35140898-0 2022 Punicalagin Alleviates Aged Bronchial Asthma by Inhibiting Th2 Differentiation through IL-4/STAT6 and Jagged1/Notch Pathways. th2 59-62 signal transducer and activator of transcription 6 Homo sapiens 92-97 35140898-0 2022 Punicalagin Alleviates Aged Bronchial Asthma by Inhibiting Th2 Differentiation through IL-4/STAT6 and Jagged1/Notch Pathways. th2 59-62 jagged canonical Notch ligand 1 Homo sapiens 102-109 35020843-11 2022 Exposure to CCp VLF CD4 + T cell-conditioned medium induced de novo Th2 response. th2 68-71 CD4 molecule Homo sapiens 20-23 35204086-5 2022 Notably, PM-exposed Nrf2-/- offspring showed a decreased pulmonary Th1/Th2 ratio, indicating a Th2 bias. th2 71-74 nuclear factor, erythroid derived 2, like 2 Mus musculus 20-24 35204086-5 2022 Notably, PM-exposed Nrf2-/- offspring showed a decreased pulmonary Th1/Th2 ratio, indicating a Th2 bias. th2 95-98 nuclear factor, erythroid derived 2, like 2 Mus musculus 20-24 35065132-5 2022 TSLP affects the pathogenesis of AD by activating Th2 responses and impairing epidermal barrier integrity. th2 50-53 thymic stromal lymphopoietin Homo sapiens 0-4 35162939-12 2022 Our study suggests that PM10 exposure could significantly increase the Th2 inflammatory pathway in NP tissues, specifically the IL-33/ST2 pathway-mediated immune response. th2 71-74 interleukin 33 Homo sapiens 128-133 35162939-12 2022 Our study suggests that PM10 exposure could significantly increase the Th2 inflammatory pathway in NP tissues, specifically the IL-33/ST2 pathway-mediated immune response. th2 71-74 ST2 Homo sapiens 134-137 35095834-8 2021 Together, these findings suggest a role for SLPI in controlling Th2 pathophysiologic processes via its impact on and/or from eosinophils. th2 64-67 secretory leukocyte peptidase inhibitor Homo sapiens 44-48 34983927-8 2022 Among molecular contexts, Th2 was the most influential on OX40L function. th2 26-29 TNF superfamily member 4 Homo sapiens 58-63 33845054-7 2021 Arsenic exposure levels of the subjects showed significant positive associations with serum Th2-mediators- interleukin (IL)-4, IL-5, IL-13, and eotaxin without any significant changes in Th1 mediators- interferon-gamma and tumor necrosis factor-alpha. th2 92-95 interleukin 4 Homo sapiens 107-125 33845054-9 2021 Notably, most of the Th2 mediators were positively associated with serum levels of total immunoglobulin E and eotaxin. th2 21-24 C-C motif chemokine ligand 11 Homo sapiens 110-117 34038479-13 2021 Basophil-derived IL-4 might be a crucial early signal for immune induction, modulating of immune responses towards Th2 immunity and IgE production. th2 115-118 interleukin 4 Equus caballus 17-21 34022896-15 2021 CONCLUSION: These data strongly suggest that both IL-17 and IL-22 are required for Th2-low endotype associated biology and that a RORgammat inhibitor may provide improved clinical benefit in a severe asthma sub-population of patients by blocking both IL-17 and IL-22 biology compared with blocking IL-17 alone. th2 83-86 interleukin 17A Homo sapiens 50-55 34022896-15 2021 CONCLUSION: These data strongly suggest that both IL-17 and IL-22 are required for Th2-low endotype associated biology and that a RORgammat inhibitor may provide improved clinical benefit in a severe asthma sub-population of patients by blocking both IL-17 and IL-22 biology compared with blocking IL-17 alone. th2 83-86 interleukin 22 Homo sapiens 60-65 33993100-11 2021 CONCLUSION: This study indicates that F. hepatica FABP and TE can suppress the inflammatory responses in EAE-induced mice and shift the immune system toward Th2 responses. th2 157-160 glutamatic-oxaloacetic transaminase 2, mitochondrial Mus musculus 50-54 34025655-9 2021 Thus, we analyzed the effect of VitD and PGE2 and observed that VitD promotes a regulatory Th2-like response with CCR8 expression whilst PGE2 also modulated CCR8 but inhibited cytokine production in combination with VitD. th2 91-94 C-C motif chemokine receptor 8 Homo sapiens 114-118 33539779-9 2021 Together these findings demonstrate that miR155 promotes susceptibility to CL caused by L. major by promoting Th2 response and inhibiting DC function. th2 110-113 microRNA 155 Mus musculus 41-47 32911880-8 2021 HRV infection enhances the Th2 environment by modulating PD-L1 and PD-L2 expression levels in allergic mucosa and by increasing the IL-4/IFN-gamma ratio in non-allergic mucosa. th2 27-30 CD274 molecule Homo sapiens 57-62 32911880-8 2021 HRV infection enhances the Th2 environment by modulating PD-L1 and PD-L2 expression levels in allergic mucosa and by increasing the IL-4/IFN-gamma ratio in non-allergic mucosa. th2 27-30 programmed cell death 1 ligand 2 Homo sapiens 67-72 33753135-6 2021 Absence of Gal-3 in C57Bl6 mice favors Th2 mediated inflammatory myocarditis but attenuate fibrosis. th2 39-42 lectin, galactose binding, soluble 3 Mus musculus 11-16 33096083-0 2021 Inverse correlation of TRIM32 and PKCzeta in Th2 biased inflammation. th2 45-48 tripartite motif-containing 32 Mus musculus 23-29 33096083-0 2021 Inverse correlation of TRIM32 and PKCzeta in Th2 biased inflammation. th2 45-48 protein kinase C zeta Homo sapiens 34-41 33096083-3 2021 In our previous studies, we showed that Trim32 null mice developed Th2 biased skin inflammation in response to imiquimod and associated low level of TRIM32 with AD. th2 67-70 tripartite motif-containing 32 Mus musculus 40-46 33096083-5 2021 Analysis of TRIM32-associated proteins from public databases identified PKCzeta as a TRIM32-associated protein that contributes to the regulation of Th2 signaling. th2 149-152 tripartite motif-containing 32 Mus musculus 12-18 33096083-5 2021 Analysis of TRIM32-associated proteins from public databases identified PKCzeta as a TRIM32-associated protein that contributes to the regulation of Th2 signaling. th2 149-152 protein kinase C zeta Homo sapiens 72-79 33096083-5 2021 Analysis of TRIM32-associated proteins from public databases identified PKCzeta as a TRIM32-associated protein that contributes to the regulation of Th2 signaling. th2 149-152 tripartite motif-containing 32 Mus musculus 85-91 33976586-17 2021 Conclusion: CD40 siRNA therapy shows promise for chronic AR as it significantly attenuated allergic symptoms and Th2-related inflammation and upregulated Foxp3+ Tregs. th2 113-116 CD40 antigen Mus musculus 12-16 33976586-17 2021 Conclusion: CD40 siRNA therapy shows promise for chronic AR as it significantly attenuated allergic symptoms and Th2-related inflammation and upregulated Foxp3+ Tregs. th2 113-116 ferredoxin reductase Mus musculus 57-59 33902339-9 2021 DT390-Cap induced slightly higher Th2-associated interleukin-4 production than Cap alone but did not affect Th1-associated interferon-gamma production. th2 34-37 interleukin 4 Homo sapiens 49-62 33601665-8 2021 Furthermore, PFOS and PFOA enhanced the Th2 response in Jurkat cells via STAT6 activation; and the effect of PFOS exposure on GATA-3, IL-4 and IFN-gamma was blocked after the expression of STAT6 was suppressed in Jurkat cells, however, the effects of PFOA exposure were only partially blocked. th2 40-43 signal transducer and activator of transcription 6 Homo sapiens 73-78 33601665-8 2021 Furthermore, PFOS and PFOA enhanced the Th2 response in Jurkat cells via STAT6 activation; and the effect of PFOS exposure on GATA-3, IL-4 and IFN-gamma was blocked after the expression of STAT6 was suppressed in Jurkat cells, however, the effects of PFOA exposure were only partially blocked. th2 40-43 interferon gamma Homo sapiens 143-152 33601665-8 2021 Furthermore, PFOS and PFOA enhanced the Th2 response in Jurkat cells via STAT6 activation; and the effect of PFOS exposure on GATA-3, IL-4 and IFN-gamma was blocked after the expression of STAT6 was suppressed in Jurkat cells, however, the effects of PFOA exposure were only partially blocked. th2 40-43 signal transducer and activator of transcription 6 Homo sapiens 189-194 33873179-0 2021 Inhibition of Both Cyclooxygenase-1 and -2 Promotes Epicutaneous Th2 and Th17 Sensitization and Allergic Airway Inflammation on Subsequent Airway Exposure to Protease Allergen in Mice. th2 65-68 prostaglandin-endoperoxide synthase 1 Mus musculus 19-42 33936062-11 2021 Inhibition of RhoA suppressed BaP and Der f 1 co-exposure-induced airway hyper-responsiveness, Th2-associated airway inflammation, and TGFbeta1 signaling activation in asthma. th2 95-98 ras homolog family member A Homo sapiens 14-18 33453147-7 2021 H2 O2 , an enzymatic product of VAP-1, which promoted the production of IL-4 by mouse Th2 and inhibited IFN-gamma by mouse Th1 and human tumor-infiltrating lymphocytes, was decreased in tumors and CD31+ tumor vascular endothelial cells in the TMEs of mice treated with VAP-1 inhibitor. th2 86-89 amine oxidase, copper containing 3 Mus musculus 32-37 33453147-7 2021 H2 O2 , an enzymatic product of VAP-1, which promoted the production of IL-4 by mouse Th2 and inhibited IFN-gamma by mouse Th1 and human tumor-infiltrating lymphocytes, was decreased in tumors and CD31+ tumor vascular endothelial cells in the TMEs of mice treated with VAP-1 inhibitor. th2 86-89 interleukin 4 Mus musculus 72-76 33508653-12 2021 Regarding the role of IL-4 in stimulating the Th2-related immune responses, this imbalance could consider as a possible mechanism in alloantibody responses of thalassemia patients. th2 46-49 interleukin 4 Homo sapiens 22-26 32920093-9 2021 Furthermore, transgenic mice with ROS-resistant CaMKII MM-VVdelta showed attenuation of Th2-associated lung inflammation and autophagy. th2 88-91 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 48-54 33529171-5 2021 IP KO Treg had significantly enhanced expression of immunoglobulin-like transcript 3 (ILT3) compared to wild-type Treg, which may contribute to the impairment of the IP KO Treg"s ability to suppress Th2 responses. th2 199-202 leukocyte immunoglobulin-like receptor, subfamily B, member 4A Mus musculus 52-84 33529171-5 2021 IP KO Treg had significantly enhanced expression of immunoglobulin-like transcript 3 (ILT3) compared to wild-type Treg, which may contribute to the impairment of the IP KO Treg"s ability to suppress Th2 responses. th2 199-202 leukocyte immunoglobulin-like receptor, subfamily B, member 4A Mus musculus 86-90 33619513-10 2021 Inhibiting mTORC1 can help restore the Th2/Treg balance. th2 39-42 CREB regulated transcription coactivator 1 Mus musculus 11-17 33833764-9 2021 The phenotype of the Spl-exposed T cells shifted towards a Th2 or Th17 profile in CF but to a Th1 profile in controls. th2 59-62 sphingosine-1-phosphate lyase 1 Homo sapiens 21-24 33730377-2 2021 A Th2 polarized response with overproduction of IL-13 and IL-4 is typical of atopic dermatitis.1 Dupilumab, a monoclonal antibody that inhibits both IL-13 and IL-4 is effective in atopic dermatitis.2 Since its 2017 US Food and Drug Administration approval for this indication, case reports have suggested that dupilumab may lead to development of psoriasis. th2 2-5 interleukin 13 Homo sapiens 48-53 33730377-2 2021 A Th2 polarized response with overproduction of IL-13 and IL-4 is typical of atopic dermatitis.1 Dupilumab, a monoclonal antibody that inhibits both IL-13 and IL-4 is effective in atopic dermatitis.2 Since its 2017 US Food and Drug Administration approval for this indication, case reports have suggested that dupilumab may lead to development of psoriasis. th2 2-5 interleukin 4 Homo sapiens 58-62 33730377-2 2021 A Th2 polarized response with overproduction of IL-13 and IL-4 is typical of atopic dermatitis.1 Dupilumab, a monoclonal antibody that inhibits both IL-13 and IL-4 is effective in atopic dermatitis.2 Since its 2017 US Food and Drug Administration approval for this indication, case reports have suggested that dupilumab may lead to development of psoriasis. th2 2-5 interleukin 13 Homo sapiens 149-154 33730377-2 2021 A Th2 polarized response with overproduction of IL-13 and IL-4 is typical of atopic dermatitis.1 Dupilumab, a monoclonal antibody that inhibits both IL-13 and IL-4 is effective in atopic dermatitis.2 Since its 2017 US Food and Drug Administration approval for this indication, case reports have suggested that dupilumab may lead to development of psoriasis. th2 2-5 interleukin 4 Homo sapiens 159-163 33726554-0 2021 Combined Treatment With H1 and H4 Receptor Antagonists Improves Th2 Inflammatory Responses in the Nasal Mucosa of Allergic Rhinitis Rats. th2 64-67 histamine receptor H4 Rattus norvegicus 31-42 33726554-4 2021 OBJECTIVES: We aimed to assess the effects of combined treatment with H1R and H4R antagonists on Th2 inflammatory responses in the nasal mucosa of AR rats. th2 97-100 histamine receptor H 1 Rattus norvegicus 70-73 33726554-4 2021 OBJECTIVES: We aimed to assess the effects of combined treatment with H1R and H4R antagonists on Th2 inflammatory responses in the nasal mucosa of AR rats. th2 97-100 histamine receptor H4 Rattus norvegicus 78-81 33726554-4 2021 OBJECTIVES: We aimed to assess the effects of combined treatment with H1R and H4R antagonists on Th2 inflammatory responses in the nasal mucosa of AR rats. th2 97-100 ferredoxin reductase Rattus norvegicus 147-149 33726554-11 2021 CONCLUSION: H4R antagonist acted synergistically with H1R antagonist to reduce Th2 inflammatory responses by down-regulating CD86 and OX40L expression in the nasal mucosa of AR rats. th2 79-82 histamine receptor H4 Rattus norvegicus 12-15 33726554-11 2021 CONCLUSION: H4R antagonist acted synergistically with H1R antagonist to reduce Th2 inflammatory responses by down-regulating CD86 and OX40L expression in the nasal mucosa of AR rats. th2 79-82 histamine receptor H 1 Rattus norvegicus 54-57 33726554-11 2021 CONCLUSION: H4R antagonist acted synergistically with H1R antagonist to reduce Th2 inflammatory responses by down-regulating CD86 and OX40L expression in the nasal mucosa of AR rats. th2 79-82 ferredoxin reductase Rattus norvegicus 174-176 33748288-2 2021 Recently, it was reported that NMU induced rapid ILC2 activation and Th2 responses in allergic diseases. th2 69-72 neuromedin U Mus musculus 31-34 33746954-14 2021 In conclusion, prophylactic treatment with holo-BLG protected against allergy in an antigen-specific and -unspecific manner by decreasing antigen presentation, specific antibody production and abrogating a Th2-response. th2 206-209 beta-lactoglobulin Bos taurus 48-51 33662453-4 2021 Dupilumab modulates the Th2-related immune response, demonstrating that IL-4 and IL-13 contribute to epidermal hyperplasia, skin homeostasis, and innate immune responses on the skin surface in AD. th2 24-27 interleukin 4 Homo sapiens 72-76 33662453-4 2021 Dupilumab modulates the Th2-related immune response, demonstrating that IL-4 and IL-13 contribute to epidermal hyperplasia, skin homeostasis, and innate immune responses on the skin surface in AD. th2 24-27 interleukin 13 Homo sapiens 81-86 33474864-1 2021 PURPOSE: MicroRNA-21 (miR-21) influences the Th2 immune pathway by suppressing the expressions of interleukin (IL)-12 and interferon (IFN)-gamma. th2 45-48 microRNA 21a Mus musculus 9-20 33474864-1 2021 PURPOSE: MicroRNA-21 (miR-21) influences the Th2 immune pathway by suppressing the expressions of interleukin (IL)-12 and interferon (IFN)-gamma. th2 45-48 microRNA 21a Mus musculus 22-28 33474864-1 2021 PURPOSE: MicroRNA-21 (miR-21) influences the Th2 immune pathway by suppressing the expressions of interleukin (IL)-12 and interferon (IFN)-gamma. th2 45-48 interferon gamma Mus musculus 122-144 33692795-14 2021 WSB1/IL21R pathways could provide a potential target for the treatment of Th2-mediated diseases. th2 74-77 WD repeat and SOCS box containing 1 Homo sapiens 0-4 33692795-14 2021 WSB1/IL21R pathways could provide a potential target for the treatment of Th2-mediated diseases. th2 74-77 interleukin 21 receptor Homo sapiens 5-10 33643264-8 2021 During systemic disease, IL-18 drives protective Th1 responses, while IL-33 promotes Th2 and suppresses Th1 immunity. th2 85-88 interleukin 33 Homo sapiens 70-75 33212303-1 2021 GSK2245035, a small molecule Toll-like Receptor 7 (TLR7) agonist developed for immunomodulatory treatment for allergic airways disease, aimed to reduce Th2 and enhance Th1/Treg responses to aeroallergens via the local induction of type I interferons (IFNs). th2 152-155 toll-like receptor 7 Macaca fascicularis 29-49 33212303-1 2021 GSK2245035, a small molecule Toll-like Receptor 7 (TLR7) agonist developed for immunomodulatory treatment for allergic airways disease, aimed to reduce Th2 and enhance Th1/Treg responses to aeroallergens via the local induction of type I interferons (IFNs). th2 152-155 toll-like receptor 7 Macaca fascicularis 51-55 33436376-7 2021 RESULTS: cTfh increased with elevated expression of inducible T-cell costimulator (ICOS) in patients with MG. cTfh shifted to Th2 and Th17 over Th1 in MG. ICOShighcTfh produced significantly higher levels of interleukin (IL)-21, IL-4, and IL-17A than ICOSlow cTfh only in patients with MG. th2 126-129 inducible T cell costimulator Homo sapiens 83-87 33485489-5 2021 Pro-inflammatory cytokines IL12 and TNFalpha generate Th2 response which helps in active phagocytosis of parasite whereas an anti-inflammatory cytokine like IL10 mediate parasite promotion by blocking autophagic pathways and inhibiting phagocytic actions. th2 54-57 tumor necrosis factor Homo sapiens 36-44 33788194-7 2021 "T2 high asthma" has an increased Th2 response triggered by elevation of IL-4, IL-5 and IL-13 and other inflammatory mediators, leading to increased eosinophilic inflammation. th2 34-37 interleukin 4 Homo sapiens 73-77 33788194-7 2021 "T2 high asthma" has an increased Th2 response triggered by elevation of IL-4, IL-5 and IL-13 and other inflammatory mediators, leading to increased eosinophilic inflammation. th2 34-37 interleukin 5 Homo sapiens 79-83 33788194-7 2021 "T2 high asthma" has an increased Th2 response triggered by elevation of IL-4, IL-5 and IL-13 and other inflammatory mediators, leading to increased eosinophilic inflammation. th2 34-37 interleukin 13 Homo sapiens 88-93 32639640-8 2021 Significant negative correlations were identified between Th2 measures and epidermal barrier gene-subsets and individual genes (FLG with IL-4R and CCL17; r<-0.4, p<0.05). th2 58-61 filaggrin Homo sapiens 128-131 32639640-8 2021 Significant negative correlations were identified between Th2 measures and epidermal barrier gene-subsets and individual genes (FLG with IL-4R and CCL17; r<-0.4, p<0.05). th2 58-61 interleukin 4 receptor Homo sapiens 137-142 32639640-8 2021 Significant negative correlations were identified between Th2 measures and epidermal barrier gene-subsets and individual genes (FLG with IL-4R and CCL17; r<-0.4, p<0.05). th2 58-61 C-C motif chemokine ligand 17 Homo sapiens 147-152 32970964-8 2021 A lack of TLR2 signaling recapitulated the exacerbation of the A.fum Th2 response observed in the absence of MyD88 signaling, whereas TLR2 agonist dampened the response induced with A.fum and C.sph conidia. th2 69-72 toll-like receptor 2 Mus musculus 10-14 32496280-4 2021 Selective TH2 inhibitors, such as dupilumab, may attenuate ACD when the delayed hypersensitivity response is due to TH2-predominate activation; conversely, it may have no effect on ACD if it is elicited via TH1 or TH17 pathways. th2 10-13 negative elongation factor complex member C/D Homo sapiens 207-210 33280431-10 2021 Expert opinion: Although the current trend is to consider Th2- and ILC2-driven pathways as two separate pathogenic mechanisms, recent data underscore that adaptive Th2- and innate cell responses represent two integrated systems in the production of IL-4, IL-5 and IL-13 leading to the current "concept" of type 2 inflammation. th2 164-167 interleukin 4 Homo sapiens 249-253 33280431-10 2021 Expert opinion: Although the current trend is to consider Th2- and ILC2-driven pathways as two separate pathogenic mechanisms, recent data underscore that adaptive Th2- and innate cell responses represent two integrated systems in the production of IL-4, IL-5 and IL-13 leading to the current "concept" of type 2 inflammation. th2 164-167 interleukin 5 Homo sapiens 255-259 33280431-10 2021 Expert opinion: Although the current trend is to consider Th2- and ILC2-driven pathways as two separate pathogenic mechanisms, recent data underscore that adaptive Th2- and innate cell responses represent two integrated systems in the production of IL-4, IL-5 and IL-13 leading to the current "concept" of type 2 inflammation. th2 164-167 interleukin 13 Homo sapiens 264-269 33337558-7 2021 Following injection of AChE-edited schistosome eggs into the tail veins of mice, an significantly enhanced Th2 response involving IL-4, -5, -10, and-13 was detected in lung cells and splenocytes in mice injected with X5-KI eggs in comparison to control mice injected with unmutated eggs. th2 107-110 acetylcholinesterase Mus musculus 23-27 33337558-7 2021 Following injection of AChE-edited schistosome eggs into the tail veins of mice, an significantly enhanced Th2 response involving IL-4, -5, -10, and-13 was detected in lung cells and splenocytes in mice injected with X5-KI eggs in comparison to control mice injected with unmutated eggs. th2 107-110 interleukin 4 Mus musculus 130-151 33337558-8 2021 A Th2-predominant response, with increased levels of IL-4, -13, and GATA3, also was induced by X5 KI eggs in small intestine-draining mesenteric lymph node cells when the gene-edited eggs were introduced into the subserosa of the ileum of the mice. th2 2-5 interleukin 4 Mus musculus 53-62 33337558-8 2021 A Th2-predominant response, with increased levels of IL-4, -13, and GATA3, also was induced by X5 KI eggs in small intestine-draining mesenteric lymph node cells when the gene-edited eggs were introduced into the subserosa of the ileum of the mice. th2 2-5 GATA binding protein 3 Mus musculus 68-73 33010253-1 2021 BACKGROUND & AIMS: IL-33/IL-1F11 is an important mediator for the development of Th2-driven inflammatory disorders and has also been implicated in the pathogenesis of GI-related cancers, including gastric carcinoma. th2 81-84 interleukin 33 Mus musculus 19-24 33010253-1 2021 BACKGROUND & AIMS: IL-33/IL-1F11 is an important mediator for the development of Th2-driven inflammatory disorders and has also been implicated in the pathogenesis of GI-related cancers, including gastric carcinoma. th2 81-84 interleukin 33 Mus musculus 25-32 33633972-3 2021 We hypothesized that Th2 high tumors are highly proliferative, and thus more likely to respond to NAC in ER-positive breast cancer. th2 21-24 estrogen receptor 1 Homo sapiens 105-107 33633972-11 2021 Th2 levels may be a biomarker in patient selection for NAC in ER-positive breast cancer. th2 0-3 estrogen receptor 1 Homo sapiens 62-64 32667158-7 2021 In the analysis of the humoral immune response, AJ-Ang II mainly elicited IgG1 antibodies and IL-4 and IL-10 production, as measured by an enzyme-linked immune absorbent spot assay, which suggests the induction of a Th2 response. th2 216-219 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 51-57 32667158-7 2021 In the analysis of the humoral immune response, AJ-Ang II mainly elicited IgG1 antibodies and IL-4 and IL-10 production, as measured by an enzyme-linked immune absorbent spot assay, which suggests the induction of a Th2 response. th2 216-219 immunoglobulin heavy constant gamma 1 (G1m marker) Mus musculus 74-78 32667158-7 2021 In the analysis of the humoral immune response, AJ-Ang II mainly elicited IgG1 antibodies and IL-4 and IL-10 production, as measured by an enzyme-linked immune absorbent spot assay, which suggests the induction of a Th2 response. th2 216-219 interleukin 4 Mus musculus 94-98 32667158-7 2021 In the analysis of the humoral immune response, AJ-Ang II mainly elicited IgG1 antibodies and IL-4 and IL-10 production, as measured by an enzyme-linked immune absorbent spot assay, which suggests the induction of a Th2 response. th2 216-219 interleukin 10 Mus musculus 103-108 32930456-9 2021 Th2-related factors (IL-4 and IL-13) were increased with IL-4 and sCD40L present at increased levels in males compared with females. th2 0-3 interleukin 4 Homo sapiens 21-25 32930456-9 2021 Th2-related factors (IL-4 and IL-13) were increased with IL-4 and sCD40L present at increased levels in males compared with females. th2 0-3 interleukin 13 Homo sapiens 30-35 32930456-9 2021 Th2-related factors (IL-4 and IL-13) were increased with IL-4 and sCD40L present at increased levels in males compared with females. th2 0-3 interleukin 4 Homo sapiens 57-61 32518367-6 2021 Together, our data imply that VEGFR-3 activation in allergic airways helps to both initiate the acute inflammatory response and regulate the adaptive (memory) response, possibly in part by shifting the TReg/Th2 balance. th2 207-210 FMS-like tyrosine kinase 4 Mus musculus 30-37 33383090-9 2021 RESULTS: We found that IL-4Ralpha signalling on B cells was important for optimal TH2 allergic immune responses mainly when the load of antigen is limited. th2 82-85 interleukin 4 receptor, alpha Mus musculus 23-33 33383090-12 2021 CONCLUSION: IL-4Ralpha signalling on B cells is deleterious in allergic asthma as it is required for optimal TH2 responses, Be2 function, GC formation and T follicular helper cells, especially when the load of the antigen is limiting. th2 109-112 interleukin 4 receptor, alpha Mus musculus 12-22 33378690-0 2021 Peanut protein acts as a Th2 adjuvant by inducing RALDH2 in human antigen-presenting cells. th2 25-28 aldehyde dehydrogenase 1 family member A2 Homo sapiens 50-56 33368331-3 2021 However, cutaneous application on mice promotes Th2-driven inflammation resembling atopic dermatitis and relying on Thymic Stromal Lymphopoietin (TSLP) from keratinocytes and T-cell orientation by TSLP-stimulated skin DCs. th2 48-51 thymic stromal lymphopoietin Mus musculus 197-201 33424850-4 2020 In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the insulin-like growth factor 2 receptor (Igf2r), concomitant with enhanced Igf2r expression and increased apoptosis prominently in CD8alpha+ DCs upon ligand stimulation, with consequent reduction in their IL-12 secretion and subsequent T cell-derived IFN-gamma, thereby promoting a default Th2-associated pulmonary allergic response. th2 417-420 insulin-like growth factor 2 receptor Mus musculus 129-166 33424850-4 2020 In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the insulin-like growth factor 2 receptor (Igf2r), concomitant with enhanced Igf2r expression and increased apoptosis prominently in CD8alpha+ DCs upon ligand stimulation, with consequent reduction in their IL-12 secretion and subsequent T cell-derived IFN-gamma, thereby promoting a default Th2-associated pulmonary allergic response. th2 417-420 insulin-like growth factor 2 receptor Mus musculus 168-173 33443037-8 2020 We show that early inhibition of RIP2 was sufficient to reduce lung histopathology and local airway inflammation while reducing the Th2 immune response. th2 132-135 receptor interacting serine/threonine kinase 2 Homo sapiens 33-37 33327561-4 2020 In addition, bone marrow-derived dendritic cells (BMDCs) from Flt3 KO mice directed Th2 immune responses in vitro, and the adoptive transfer of these BMDCs exacerbated allergic asthma with more marked Th2 responses than that of BMDCs from wild-type (WT) mice. th2 84-87 FMS-like tyrosine kinase 3 Mus musculus 62-66 33327561-6 2020 In conclusion, we revealed that Flt3-independent CD11b+ DCs direct Th2 responses with the elevated OX40L and are the primary cause of allergic asthma. th2 67-70 FMS-like tyrosine kinase 3 Mus musculus 32-36 33327561-6 2020 In conclusion, we revealed that Flt3-independent CD11b+ DCs direct Th2 responses with the elevated OX40L and are the primary cause of allergic asthma. th2 67-70 integrin alpha M Mus musculus 49-54 33327561-6 2020 In conclusion, we revealed that Flt3-independent CD11b+ DCs direct Th2 responses with the elevated OX40L and are the primary cause of allergic asthma. th2 67-70 tumor necrosis factor (ligand) superfamily, member 4 Mus musculus 99-104 32958257-4 2020 The results showed that the high concentrations of metal cations and PAHs in PM2.5 could aggravate Th2-dominant allergic inflammation in AR model and cause redox imbalance, accompanied by nasal epithelial cell stripping and eosinophil infiltration, while NAC intervention could alleviate the clinical symptoms of AR model after PM2.5 exposure, correct the redox imbalance, reduce the Th2 cytokines, reduce eosinophil infiltration, and promote the moderate regeneration of epithelial cells. th2 99-102 ferredoxin reductase Rattus norvegicus 137-139 33276813-13 2020 Resistance to infection is due to the production of IL-25, which acts autonomously from Th2 response in terms of parasite clearance. th2 88-91 interleukin 25 Mus musculus 52-57 33274950-1 2020 BACKGROUND: The significance of periostin as a biomarker of Th2-induced airway inflammation has recently been highlighted in adult patients with allergic diseases. th2 60-63 periostin Homo sapiens 32-41 32947151-15 2020 We also detected that the Th2/Treg response was more pronounced in MIF-/- mice. th2 26-29 macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mus musculus 67-70 32977238-9 2020 CONCLUSIONS: CS induces IL-33 expression in intestinal epithelial cells to promote Th2 polarization in the intestinal tissues and facilitates FA development. th2 83-86 interleukin 33 Mus musculus 24-29 32304753-0 2020 TSLP drives acute Th2 differentiation in lungs. th2 18-21 thymic stromal lymphopoietin Mus musculus 0-4 32304753-6 2020 RESULTS: We show that TSLP can directly promote Th2 differentiation in the lung, independent of the draining lymph node. th2 48-51 thymic stromal lymphopoietin Mus musculus 22-26 32304753-8 2020 Th2-driven airway eosinophilia is attenuated by ablation of CD11cIM, or by selective deficiency of TSLPR signaling in these cells. th2 0-3 cytokine receptor-like factor 2 Mus musculus 99-104 32304753-10 2020 CONCLUSION: These findings indicate a novel mechanistic role for TSLP and CD11cIM in the development of acute Th2-dependent allergic airway inflammation. th2 110-113 thymic stromal lymphopoietin Mus musculus 65-69 33185498-6 2020 Therefore, this study suggested that RMFE could be an effective treatment of AD induced by Th2-mediated immune responses by suppressing proliferation of CD4+ T cells via increased HO-1. th2 91-94 CD4 antigen Mus musculus 153-156 33185498-6 2020 Therefore, this study suggested that RMFE could be an effective treatment of AD induced by Th2-mediated immune responses by suppressing proliferation of CD4+ T cells via increased HO-1. th2 91-94 heme oxygenase 1 Mus musculus 180-184 33174031-14 2020 In conclusion, these results indicated that ATL may suppress antigen-specific Th2 responses in an OVA-induced allergic asthma model via regulating DCs. th2 78-81 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 98-101 33020661-3 2020 Here, we demonstrate that, like humans, Dock8-/- mice have a profound type 2 CD4+ helper T (TH2) cell bias upon pulmonary infection with Cryptococcus neoformans and other non-TH2 stimuli. th2 92-95 dedicator of cytokinesis 8 Homo sapiens 40-45 33329534-2 2020 IL-33 has long been studied in the context of Th2-related immunopathologies, such as allergic diseases and parasitic infections. th2 46-49 interleukin 33 Homo sapiens 0-5 33299659-10 2020 Expression of Th2-related and keratinocyte-derived cytokines in the skin was associated with anti-EGFR efficacy. th2 14-17 epidermal growth factor receptor Homo sapiens 98-102 33330288-5 2020 MIS-C may be due to IgA complexes in a Th2 environment or a Th1-like response to COVID-19 antigens that developed slowly. th2 39-42 anti-Mullerian hormone Homo sapiens 0-3 33203095-2 2020 The aim of our study was to determine periostin and TSLP concentration in serum and induced sputum (IS) in patients with atopic asthma, chronic obstructive pulmonary disease (COPD), and controls, as well as to evaluate the potential link between periostin, TSLP, and Th2 immune response. th2 267-270 periostin Homo sapiens 38-47 33203095-7 2020 Very strong correlations between local periostin, TSLP, eosinophils, and IL-4 in asthma point to the link between periostin-TSLP and Th2 response. th2 133-136 periostin Homo sapiens 39-48 33203095-7 2020 Very strong correlations between local periostin, TSLP, eosinophils, and IL-4 in asthma point to the link between periostin-TSLP and Th2 response. th2 133-136 interleukin 4 Homo sapiens 73-77 33203095-7 2020 Very strong correlations between local periostin, TSLP, eosinophils, and IL-4 in asthma point to the link between periostin-TSLP and Th2 response. th2 133-136 periostin Homo sapiens 114-123 33203095-7 2020 Very strong correlations between local periostin, TSLP, eosinophils, and IL-4 in asthma point to the link between periostin-TSLP and Th2 response. th2 133-136 thymic stromal lymphopoietin Homo sapiens 124-128 33281813-3 2020 Here, we demonstrated enhanced Th2 response in circulation with significant increases in Th2 frequency, Th2/Tregs as well as IL-4 seretion in patients. th2 31-34 interleukin 4 Homo sapiens 125-129 33160971-0 2021 Combination Blockade of OX40L and CD30L Inhibits Allergen-driven Memory Th2 Reactivity and Lung Inflammation. th2 72-75 tumor necrosis factor (ligand) superfamily, member 4 Mus musculus 24-29 33160971-0 2021 Combination Blockade of OX40L and CD30L Inhibits Allergen-driven Memory Th2 Reactivity and Lung Inflammation. th2 72-75 tumor necrosis factor (ligand) superfamily, member 8 Mus musculus 34-39 33160971-6 2021 In contrast, a significant reduction in eosinophilic inflammation was observed when OX40L and CD30L were simultaneously neutralized, with dual blockade inhibiting effector memory Th2 expansion in the lungs while formation of peripherally-induced Treg remained intact. th2 179-182 tumor necrosis factor (ligand) superfamily, member 4 Mus musculus 84-89 33160971-6 2021 In contrast, a significant reduction in eosinophilic inflammation was observed when OX40L and CD30L were simultaneously neutralized, with dual blockade inhibiting effector memory Th2 expansion in the lungs while formation of peripherally-induced Treg remained intact. th2 179-182 tumor necrosis factor (ligand) superfamily, member 8 Mus musculus 94-99 32935492-13 2020 CONCLUSIONS: CHI3L1 plays a pivotal role in Th2 inflammation and M2 macrophage polarization through MAPK/ERK and PI3K/AKT phosphorylation in food allergy. th2 44-47 chitinase 3 like 1 Homo sapiens 13-19 32504246-6 2020 However, in the presence of AKT-inhibition, Th-differentiation was skewed toward more Th2-associated at the expense of Th1-associated cells. th2 86-89 AKT serine/threonine kinase 1 Homo sapiens 28-31 32613762-8 2020 Furthermore, Per2 gene expression levels were attenuated at ZT4 and elevated at ZT16, but correlated negatively with Th2 and Th17 responses associated with Gata3 and Rorgammat expression levels that were enhanced at ZT4 and reduced at ZT16 in the AR group. th2 117-120 period circadian clock 2 Mus musculus 13-17 33080435-8 2020 Th2 activates the IL-4 through IgG and IgE and mediates apoptosis with the triggering of STAT signaling. th2 0-3 interleukin 4 Homo sapiens 18-22 33178566-12 2020 Conclusion: CD11c positive DCs coexpressing TSLPR were recruited after OVA challenge which might activate Th2 allergic reaction. th2 106-109 integrin subunit alpha X Homo sapiens 12-17 33178566-12 2020 Conclusion: CD11c positive DCs coexpressing TSLPR were recruited after OVA challenge which might activate Th2 allergic reaction. th2 106-109 cytokine receptor like factor 2 Homo sapiens 44-49 33114004-0 2020 Increased Expression of TLR4 in Circulating CD4+T Cells in Patients with Allergic Conjunctivitis and In Vitro Attenuation of Th2 Inflammatory Response by Alpha-MSH. th2 125-128 toll like receptor 4 Homo sapiens 24-28 33114004-0 2020 Increased Expression of TLR4 in Circulating CD4+T Cells in Patients with Allergic Conjunctivitis and In Vitro Attenuation of Th2 Inflammatory Response by Alpha-MSH. th2 125-128 proopiomelanocortin Homo sapiens 154-163 33093516-10 2020 These results suggest that the TLR9-IL-2 axis plays an important role in Th2 inflammation by modulating IL-17A production in HDM-induced allergic asthma and that targeting of TLR9 might be a novel therapeutic method for allergic asthma. th2 73-76 toll-like receptor 9 Mus musculus 31-35 33093516-10 2020 These results suggest that the TLR9-IL-2 axis plays an important role in Th2 inflammation by modulating IL-17A production in HDM-induced allergic asthma and that targeting of TLR9 might be a novel therapeutic method for allergic asthma. th2 73-76 interleukin 2 Mus musculus 36-40 33093516-10 2020 These results suggest that the TLR9-IL-2 axis plays an important role in Th2 inflammation by modulating IL-17A production in HDM-induced allergic asthma and that targeting of TLR9 might be a novel therapeutic method for allergic asthma. th2 73-76 interleukin 17A Mus musculus 104-110 33093516-10 2020 These results suggest that the TLR9-IL-2 axis plays an important role in Th2 inflammation by modulating IL-17A production in HDM-induced allergic asthma and that targeting of TLR9 might be a novel therapeutic method for allergic asthma. th2 73-76 toll-like receptor 9 Mus musculus 175-179