PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34081457-7	2021	Star, Cyp11a1, Cyp17a1, Hsd3b1, and Insl3 transcript levels in the testis were markedly lowered in the 1-5 mg/kg PFTrDA group and the Lhb transcript level in the pituitary in the 10 mg/kg group.	pftrda	113-119	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	6-13
34081457-7	2021	Star, Cyp11a1, Cyp17a1, Hsd3b1, and Insl3 transcript levels in the testis were markedly lowered in the 1-5 mg/kg PFTrDA group and the Lhb transcript level in the pituitary in the 10 mg/kg group.	pftrda	113-119	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	15-22
34081457-7	2021	Star, Cyp11a1, Cyp17a1, Hsd3b1, and Insl3 transcript levels in the testis were markedly lowered in the 1-5 mg/kg PFTrDA group and the Lhb transcript level in the pituitary in the 10 mg/kg group.	pftrda	113-119	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	24-30
34081457-7	2021	Star, Cyp11a1, Cyp17a1, Hsd3b1, and Insl3 transcript levels in the testis were markedly lowered in the 1-5 mg/kg PFTrDA group and the Lhb transcript level in the pituitary in the 10 mg/kg group.	pftrda	113-119	insulin-like 3	Rattus norvegicus	36-41
34081457-8	2021	CYP11A1 and HSD11B1-positive Leydig cell numbers were markedly reduced after 10 mg/kg PFTrDA exposure.	pftrda	86-92	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	0-7
34081457-8	2021	CYP11A1 and HSD11B1-positive Leydig cell numbers were markedly reduced after 10 mg/kg PFTrDA exposure.	pftrda	86-92	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	12-19
34081457-10	2021	AKT1 and AMPK phosphorylation was stimulated after 10 PFTrDA mg/kg exposure.	pftrda	54-60	AKT serine/threonine kinase 1	Rattus norvegicus	0-4
34081457-10	2021	AKT1 and AMPK phosphorylation was stimulated after 10 PFTrDA mg/kg exposure.	pftrda	54-60	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	9-13
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	insulin-like 3	Rattus norvegicus	40-45
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	47-52
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	scavenger receptor class B, member 1	Rattus norvegicus	54-60
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	68-74
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	76-83
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	85-90
33683001-7	2021	PFTrDA down-regulated the expression of Insl3, Lhcgr, Scarb1, Star, Hsd3b1, Cyp17a1, Nr5a1, and Dhh as well as their proteins.	pftrda	0-6	desert hedgehog signaling molecule	Rattus norvegicus	96-99
33683001-8	2021	PFTrDA lowered the levels of antioxidants (SOD1, CAT, and GPX1), induced autophagy as shown by increased levels of LC3II and beclin1, and reduced the phosphorylation of mTOR.	pftrda	0-6	superoxide dismutase 1	Rattus norvegicus	43-47
33683001-8	2021	PFTrDA lowered the levels of antioxidants (SOD1, CAT, and GPX1), induced autophagy as shown by increased levels of LC3II and beclin1, and reduced the phosphorylation of mTOR.	pftrda	0-6	catalase	Rattus norvegicus	49-52
33683001-8	2021	PFTrDA lowered the levels of antioxidants (SOD1, CAT, and GPX1), induced autophagy as shown by increased levels of LC3II and beclin1, and reduced the phosphorylation of mTOR.	pftrda	0-6	glutathione peroxidase 1	Rattus norvegicus	58-62
33683001-8	2021	PFTrDA lowered the levels of antioxidants (SOD1, CAT, and GPX1), induced autophagy as shown by increased levels of LC3II and beclin1, and reduced the phosphorylation of mTOR.	pftrda	0-6	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	115-120
33683001-8	2021	PFTrDA lowered the levels of antioxidants (SOD1, CAT, and GPX1), induced autophagy as shown by increased levels of LC3II and beclin1, and reduced the phosphorylation of mTOR.	pftrda	0-6	beclin 1	Rattus norvegicus	125-132
33683001-8	2021	PFTrDA lowered the levels of antioxidants (SOD1, CAT, and GPX1), induced autophagy as shown by increased levels of LC3II and beclin1, and reduced the phosphorylation of mTOR.	pftrda	0-6	mechanistic target of rapamycin kinase	Rattus norvegicus	169-173
33744484-10	2021	Notably, perfluoro-n-tridecanoic acid (PFTrDA) and perfluoro-n-dodecanoic acid (PFDoA) were found to be significantly and inversely associated with INSL3, a unique indicator of Leydig cells function.	pftrda	39-45	insulin like 3	Homo sapiens	148-153
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	thyroid stimulating hormone subunit beta	Rattus norvegicus	129-136
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	NK2 homeobox 4b	Danio rerio	138-144
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	thyroid peroxidase	Danio rerio	151-154
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	solute carrier family 16 member 2	Danio rerio	156-160
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	iodothyronine deiodinase 1	Danio rerio	182-186
33182161-5	2021	Following a 5 d exposure to PFTrDA, zebrafish larvae showed upregulation of the genes responsible for thyroid hormone synthesis (tshbeta, nkx2.1, nis, tpo, mct8) and (de)activation (dio1, dio2).	pftrda	28-34	iodothyronine deiodinase 2	Danio rerio	188-192
33182161-8	2021	In GH3 cells, exposure to PFUnDA and PFTrDA upregulated Tshbeta gene, suggesting that these PFCAs increase thyroid hormone synthesis through stimulation by Tsh.	pftrda	37-43	thyroid stimulating hormone subunit beta	Rattus norvegicus	56-63