PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33639958-6	2021	The genome-wide alteration of gene expression was studied by high throughput sequencing analysis, where 75 genes were found to be dysregulated after SiNP exposure, among which ACOT2, SCD1, and CPT1A were demonstrated to regulate the biosynthesis of unsaturated fatty acids.	sinp	149-153	acyl-CoA thioesterase 2	Mus musculus	176-181
33714870-7	2021	Besides, SiNP induced uterine inflammation in vivo, which aggravated with the observation prolongation within 24 h. Overall, SiNPs were visualized by coupling with FITC, and the uterine accumulation of SiNP induced fatty acid metabolic disorder, biological dysfunction, and trophoblast apoptosis, which were mediated in part by the PPARgamma signaling pathway.	sinp	9-13	peroxisome proliferator activated receptor gamma	Mus musculus	332-341
33639958-6	2021	The genome-wide alteration of gene expression was studied by high throughput sequencing analysis, where 75 genes were found to be dysregulated after SiNP exposure, among which ACOT2, SCD1, and CPT1A were demonstrated to regulate the biosynthesis of unsaturated fatty acids.	sinp	149-153	stearoyl-Coenzyme A desaturase 1	Mus musculus	183-187
33639958-6	2021	The genome-wide alteration of gene expression was studied by high throughput sequencing analysis, where 75 genes were found to be dysregulated after SiNP exposure, among which ACOT2, SCD1, and CPT1A were demonstrated to regulate the biosynthesis of unsaturated fatty acids.	sinp	149-153	carnitine palmitoyltransferase 1a, liver	Mus musculus	193-198
33639958-8	2021	In conclusion, the successful conjugation of FITC onto SiNP facilitated the tracking of SiNP in vitro and in vivo, while exposure to FITC-SiNP induced uterine metabolic disorder, which was regulated by the ACOT/CPT1A/SCD1 axis through the biosynthesis of unsaturated fatty acids signaling pathway.	sinp	55-59	stearoyl-Coenzyme A desaturase 1	Mus musculus	217-221
32538421-5	2020	In line with the transmission electron microscopy (TEM)-observed abnormalities in the mitochondrial morphology and length distribution, a fission phenotype was manifested in the mitochondria of SiNP-exposed cells, and up-regulated DRP1 and FIS1, and down-regulated MFN1, were detected.	sinp	194-198	fission, mitochondrial 1	Homo sapiens	240-244
32387908-5	2020	In addition, SiNP exposure increased reactive oxygen species (ROS) production and activated extracellular regulated protein kinases (ERKs) and c-Jun N-terminal kinase (JNK).	sinp	13-17	mitogen-activated protein kinase 1	Homo sapiens	133-137
32387908-5	2020	In addition, SiNP exposure increased reactive oxygen species (ROS) production and activated extracellular regulated protein kinases (ERKs) and c-Jun N-terminal kinase (JNK).	sinp	13-17	mitogen-activated protein kinase 8	Homo sapiens	143-166
32387908-5	2020	In addition, SiNP exposure increased reactive oxygen species (ROS) production and activated extracellular regulated protein kinases (ERKs) and c-Jun N-terminal kinase (JNK).	sinp	13-17	mitogen-activated protein kinase 8	Homo sapiens	168-171
32387908-6	2020	The inhibition of ROS and ERKs effectively protected the SiNP-induced downregulation of ZO-1 mRNA and protein expression, but had no effect on ZO-2 or occludin expression.	sinp	57-61	mitogen-activated protein kinase 1	Homo sapiens	26-30
32387908-6	2020	The inhibition of ROS and ERKs effectively protected the SiNP-induced downregulation of ZO-1 mRNA and protein expression, but had no effect on ZO-2 or occludin expression.	sinp	57-61	tight junction protein 1	Homo sapiens	88-92
32387908-7	2020	SiNP-induced matrix metalloproteinase 9 (MMP9) protein expression appeared to be involved in occludin proteolytic degradation, in addition to SiNP-induced direct occludin protein degradation.	sinp	0-4	matrix metallopeptidase 9	Homo sapiens	41-45
32387908-7	2020	SiNP-induced matrix metalloproteinase 9 (MMP9) protein expression appeared to be involved in occludin proteolytic degradation, in addition to SiNP-induced direct occludin protein degradation.	sinp	0-4	occludin	Homo sapiens	93-101
32387908-7	2020	SiNP-induced matrix metalloproteinase 9 (MMP9) protein expression appeared to be involved in occludin proteolytic degradation, in addition to SiNP-induced direct occludin protein degradation.	sinp	0-4	occludin	Homo sapiens	162-170
32387908-7	2020	SiNP-induced matrix metalloproteinase 9 (MMP9) protein expression appeared to be involved in occludin proteolytic degradation, in addition to SiNP-induced direct occludin protein degradation.	sinp	142-146	occludin	Homo sapiens	162-170
32964349-6	2021	The results showed a significant elevation in the malondialdehyde (MDA) level concurrent with a reduction in total reduced glutathione (GSH) concentration and catalase activity in the 1000-ppm SiNP-exposed rats as well as increase in ALT and AST activity confirmed by various histopathological alterations detected in liver.	sinp	193-197	catalase	Rattus norvegicus	159-167
32964349-8	2021	Immunohistochemical findings in both liver and kidneys indicated strong expression of caspase-3 in the 1000-ppm SiNP-treated rats compared with the control and 500-ppm SiNP-treated groups.	sinp	112-116	caspase 3	Rattus norvegicus	86-95
32964349-8	2021	Immunohistochemical findings in both liver and kidneys indicated strong expression of caspase-3 in the 1000-ppm SiNP-treated rats compared with the control and 500-ppm SiNP-treated groups.	sinp	168-172	caspase 3	Rattus norvegicus	86-95
32538421-5	2020	In line with the transmission electron microscopy (TEM)-observed abnormalities in the mitochondrial morphology and length distribution, a fission phenotype was manifested in the mitochondria of SiNP-exposed cells, and up-regulated DRP1 and FIS1, and down-regulated MFN1, were detected.	sinp	194-198	mitofusin 1	Homo sapiens	265-269
32538421-6	2020	Furthermore, the enhanced LC3II level, colocalization of the mitochondria and lysosomes, activated PINK1/Parkin signaling, and accumulated p62 in the SiNP-exposed cells suggested mitophagy disorder triggered by SiNPs.	sinp	150-154	PTEN induced kinase 1	Homo sapiens	99-104
32538421-6	2020	Furthermore, the enhanced LC3II level, colocalization of the mitochondria and lysosomes, activated PINK1/Parkin signaling, and accumulated p62 in the SiNP-exposed cells suggested mitophagy disorder triggered by SiNPs.	sinp	150-154	nucleoporin 62	Homo sapiens	139-142
32397800-8	2021	Our studies not only established a powerful method for predicting regulatory kinases from the multi-omics data but also revealed a potential mechanism of SiNP-triggered autophagy activation through modulating the CDK7-CDK4 cascade.	sinp	154-158	cyclin-dependent kinase 7	Rattus norvegicus	213-217
29151191-6	2018	The protein expressions of ATM, CHK-2, P53, E2F1, P73, BAX, Caspase-9, and Caspase-3 were significantly increased, while expressions of RAD51 were down-regulated after SiNP exposure by days 15.	sinp	168-172	ataxia telangiectasia mutated	Mus musculus	27-30
29151191-6	2018	The protein expressions of ATM, CHK-2, P53, E2F1, P73, BAX, Caspase-9, and Caspase-3 were significantly increased, while expressions of RAD51 were down-regulated after SiNP exposure by days 15.	sinp	168-172	BCL2-associated X protein	Mus musculus	55-58
29151191-6	2018	The protein expressions of ATM, CHK-2, P53, E2F1, P73, BAX, Caspase-9, and Caspase-3 were significantly increased, while expressions of RAD51 were down-regulated after SiNP exposure by days 15.	sinp	168-172	RAD51 recombinase	Mus musculus	136-141
29940794-8	2018	Finally, the 2 autophagic genes LC3B and ATG12 were found to be transcriptionally upregulated by downstream ATF4 and DDIT3 in ER stress, which contributed to the SiNP-enhanced autophagosome synthesis.	sinp	162-166	microtubule associated protein 1 light chain 3 beta	Homo sapiens	32-36
29940794-8	2018	Finally, the 2 autophagic genes LC3B and ATG12 were found to be transcriptionally upregulated by downstream ATF4 and DDIT3 in ER stress, which contributed to the SiNP-enhanced autophagosome synthesis.	sinp	162-166	autophagy related 12	Homo sapiens	41-46
29940794-8	2018	Finally, the 2 autophagic genes LC3B and ATG12 were found to be transcriptionally upregulated by downstream ATF4 and DDIT3 in ER stress, which contributed to the SiNP-enhanced autophagosome synthesis.	sinp	162-166	activating transcription factor 4	Homo sapiens	108-112
29940794-8	2018	Finally, the 2 autophagic genes LC3B and ATG12 were found to be transcriptionally upregulated by downstream ATF4 and DDIT3 in ER stress, which contributed to the SiNP-enhanced autophagosome synthesis.	sinp	162-166	DNA damage inducible transcript 3	Homo sapiens	117-122
30090375-6	2016	In addition, pathway analysis and Signal-net analysis indicated that the gap junction, vascular smooth muscle contraction, and metabolic pathways, apoptosis, the MAPK signaling pathway, the calcium signaling pathway and the JAK-STAT signaling pathway were the most prominent significant pathways in SiNP-induced toxicity in zebrafish embryos.	sinp	299-303	signal transducer and activator of transcription 3 (acute-phase response factor)	Danio rerio	228-232
24831964-9	2014	Concomitantly, the expression of amyloid precursor protein (APP) was up-regulated, while amyloid-beta-degrading enzyme neprilysin was down-regulated in SiNP-treated cells.	sinp	152-156	amyloid beta precursor protein	Homo sapiens	33-58
24831964-9	2014	Concomitantly, the expression of amyloid precursor protein (APP) was up-regulated, while amyloid-beta-degrading enzyme neprilysin was down-regulated in SiNP-treated cells.	sinp	152-156	membrane metalloendopeptidase	Homo sapiens	119-129
24831964-10	2014	Finally, activity-dependent phosphorylation of glycogen syntheses kinase (GSK)-3beta at Ser9 (inactive form) was significantly decreased in SiNP-treated SK-N-SH cells.	sinp	140-144	glycogen synthase kinase 3 alpha	Homo sapiens	47-84
22632131-4	2012	Then, the fluorescent-labeled anti-CD11b was orientedly immobilized to the SiNP surface through the specific protein G-antibody interaction.	sinp	75-79	integrin alpha M	Mus musculus	35-40
22632131-7	2012	The fluorescence intensity of inflamed kidney 6 and 12 h after injection of the anti-CD11b orientedly immobilized SiNP were significantly higher than that of anti-CD11b randomly immobilized SiNP or free anti-CD11b injection.	sinp	114-118	integrin alpha M	Mus musculus	85-90
22632131-9	2012	It is concluded that the anti-CD11b orientedly immobilized SiNP are promising nanoprobes to image the inflammation site at a high intensity.	sinp	59-63	integrin alpha M	Mus musculus	30-35
22334785-9	2012	In addition, SiNP induced an upregulation of selectin P expression and glycoprotein IIb/IIIa activation on the platelet surface membrane, and led to platelet aggregation via adenosine diphosphate and matrix metalloproteinase 2-dependent mechanisms.	sinp	13-17	selectin P	Homo sapiens	45-55
22334785-9	2012	In addition, SiNP induced an upregulation of selectin P expression and glycoprotein IIb/IIIa activation on the platelet surface membrane, and led to platelet aggregation via adenosine diphosphate and matrix metalloproteinase 2-dependent mechanisms.	sinp	13-17	matrix metallopeptidase 2	Homo sapiens	200-226
21939189-4	2011	Otherwise, PPh(3) and RhCl(SiNP) equilibrate with Rh(Cl)(SiNP)(PPh(3)) (7).	sinp	27-31	caveolin 1	Homo sapiens	63-69
34110565-8	2022	Taken together, these data showed that SiNPs trigger hepatic damage through ROS-activated caspase signaling pathway, which plays a fundamental role in SiNP-induced apoptosis in the liver.	sinp	151-155	caspase 9	Homo sapiens	90-97
32397800-8	2021	Our studies not only established a powerful method for predicting regulatory kinases from the multi-omics data but also revealed a potential mechanism of SiNP-triggered autophagy activation through modulating the CDK7-CDK4 cascade.	sinp	154-158	cyclin-dependent kinase 4	Rattus norvegicus	218-222
31082419-3	2019	However, the SIRT1 response to SiNP exposure and its role in SiNP-triggered pulmonary toxicity remains unknown.	sinp	31-35	sirtuin 1	Homo sapiens	13-18
31082419-3	2019	However, the SIRT1 response to SiNP exposure and its role in SiNP-triggered pulmonary toxicity remains unknown.	sinp	61-65	sirtuin 1	Homo sapiens	13-18
31082419-7	2019	SIRT1 overexpression dramatically decreased p53 acetylation and its cytoplasmic localisation, and this was accompanied by attenuated apoptosis in SiNP-exposed cells.	sinp	146-150	sirtuin 1	Homo sapiens	0-5
30460651-9	2019	Correspondingly, the levels of Nrf2 protein were also enhanced in the SiNP-treated HUVECs, with a negative size-dependent effect relationship.	sinp	70-74	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
25843239-13	2015	On the other hand, non-coated SiNP and PEGylated SiNP showed lower interaction with mucin, indicating that these nanoparticles can interdiffuse across mucus network.	sinp	30-34	LOC100508689	Homo sapiens	84-89
25843239-13	2015	On the other hand, non-coated SiNP and PEGylated SiNP showed lower interaction with mucin, indicating that these nanoparticles can interdiffuse across mucus network.	sinp	49-53	LOC100508689	Homo sapiens	84-89
25843239-14	2015	The results of the present work provide valuable data in assessing the in vitro performance of insulin-loaded SiNP coated with mucoadhesive polymers.	sinp	110-114	insulin	Homo sapiens	95-102
18790531-10	2008	SiNP demonstrated their therapeutic potential by significantly lowering the therapeutically necessary drug dose when evaluating clinical activity score and myeloperoxidase activity (untreated control: 28.0+/-5.0 U/mg; 5ASA-solution (100mg/kg): 8.2+/-3.4 U/mg 5ASA-SiNP (25mg/kg): 5.2+/-2.4 U/mg).	sinp	0-4	myeloperoxidase	Mus musculus	156-171
34446138-6	2021	SCD1 overexpression or oleic acid efficiently reversed SiNP-induced ER stress and IR, whereas the effects of thapsigargin treatment could not be restored.	sinp	55-59	stearoyl-CoA desaturase	Homo sapiens	0-4
35427968-4	2022	First, a proteomic analysis was used to screen for critical proteins (including RPL3, HSP90AA1, SOD, PGK1, GOT1, and PNP), indicating that abnormal protein synthesis, protein misfolding, oxidative stress, and metabolic dysfunction may contribute to SiNP-induced hepatotoxicity.	sinp	249-253	ribosomal protein L3	Homo sapiens	80-84
35427968-4	2022	First, a proteomic analysis was used to screen for critical proteins (including RPL3, HSP90AA1, SOD, PGK1, GOT1, and PNP), indicating that abnormal protein synthesis, protein misfolding, oxidative stress, and metabolic dysfunction may contribute to SiNP-induced hepatotoxicity.	sinp	249-253	heat shock protein 90 alpha family class A member 1	Homo sapiens	86-94
35427968-4	2022	First, a proteomic analysis was used to screen for critical proteins (including RPL3, HSP90AA1, SOD, PGK1, GOT1, and PNP), indicating that abnormal protein synthesis, protein misfolding, oxidative stress, and metabolic dysfunction may contribute to SiNP-induced hepatotoxicity.	sinp	249-253	purine nucleoside phosphorylase	Homo sapiens	117-120
35427968-8	2022	Moreover, SOD, TKT, PGM1, GOT1, PNP, and NME2 may be key proteins for SiNP-induced hepatotoxicity.	sinp	70-74	superoxide dismutase 1	Homo sapiens	10-13
35427968-8	2022	Moreover, SOD, TKT, PGM1, GOT1, PNP, and NME2 may be key proteins for SiNP-induced hepatotoxicity.	sinp	70-74	transketolase	Homo sapiens	15-18
35427968-8	2022	Moreover, SOD, TKT, PGM1, GOT1, PNP, and NME2 may be key proteins for SiNP-induced hepatotoxicity.	sinp	70-74	phosphoglucomutase 1	Homo sapiens	20-24
35427968-8	2022	Moreover, SOD, TKT, PGM1, GOT1, PNP, and NME2 may be key proteins for SiNP-induced hepatotoxicity.	sinp	70-74	glutamic-oxaloacetic transaminase 1	Homo sapiens	26-30
35427968-8	2022	Moreover, SOD, TKT, PGM1, GOT1, PNP, and NME2 may be key proteins for SiNP-induced hepatotoxicity.	sinp	70-74	purine nucleoside phosphorylase	Homo sapiens	32-35
35427968-8	2022	Moreover, SOD, TKT, PGM1, GOT1, PNP, and NME2 may be key proteins for SiNP-induced hepatotoxicity.	sinp	70-74	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	41-45