PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18303189-4	2008	Here we report that MWCNT induces mesothelioma along with a positive control, crocidolite (blue asbestos), when administered intraperitoneally to p53 heterozygous mice that have been reported to be sensitive to asbestos.	mwcnt	20-25	transformation related protein 53, pseudogene	Mus musculus	146-149
20121055-4	2010	The potential for the oxidation of glucose at the GDH/NAD(+)/MWCNT-modified electrode remains very close to that for NADH oxidation at the MWCNT-modified electrode, but it is more negative than those for the oxidation of glucose at the MWCNT-modified electrode and for NADH oxidation at a bare glassy carbon electrode.	mwcnt	61-66	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	50-53
20121055-4	2010	The potential for the oxidation of glucose at the GDH/NAD(+)/MWCNT-modified electrode remains very close to that for NADH oxidation at the MWCNT-modified electrode, but it is more negative than those for the oxidation of glucose at the MWCNT-modified electrode and for NADH oxidation at a bare glassy carbon electrode.	mwcnt	139-144	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	50-53
20121055-4	2010	The potential for the oxidation of glucose at the GDH/NAD(+)/MWCNT-modified electrode remains very close to that for NADH oxidation at the MWCNT-modified electrode, but it is more negative than those for the oxidation of glucose at the MWCNT-modified electrode and for NADH oxidation at a bare glassy carbon electrode.	mwcnt	139-144	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	50-53
20064106-9	2010	Analysis of cell-free BAL fluids showed significantly increased levels of total proteins, lactate dehydrogenase, tumor necrosis factor-alpha, interleukin-1beta, mucin, and surfactant protein-D (SP-D) in MWCNT-treated mice at day 1 post treatment.	mwcnt	203-208	interleukin 1 beta	Mus musculus	142-159
20064106-9	2010	Analysis of cell-free BAL fluids showed significantly increased levels of total proteins, lactate dehydrogenase, tumor necrosis factor-alpha, interleukin-1beta, mucin, and surfactant protein-D (SP-D) in MWCNT-treated mice at day 1 post treatment.	mwcnt	203-208	surfactant associated protein D	Mus musculus	172-192
20064106-9	2010	Analysis of cell-free BAL fluids showed significantly increased levels of total proteins, lactate dehydrogenase, tumor necrosis factor-alpha, interleukin-1beta, mucin, and surfactant protein-D (SP-D) in MWCNT-treated mice at day 1 post treatment.	mwcnt	203-208	surfactant associated protein D	Mus musculus	194-198
19913088-6	2010	Lectins are inhibitors of the melanosome transfer pathway was used to study the uptake of MWCNT in keratinocytes, to see if they played a role in reducing the cellular uptake of MWCNT in HEK.	mwcnt	90-95	EPH receptor A3	Homo sapiens	187-190
18243872-1	2008	We have developed a multiwalled carbon nanotube/dihydropyran (MWCNT/DHP) composite sensor for the electrochemical detection of insulin in a microfluidic device.	mwcnt	62-67	insulin	Homo sapiens	127-134
18243872-6	2008	The MWCNT/DHP composite sensor has been successfully used for the direct detection of insulin secreted by islets in the microphysiometer.	mwcnt	4-9	dihydropyrimidinase	Homo sapiens	10-13
18243872-6	2008	The MWCNT/DHP composite sensor has been successfully used for the direct detection of insulin secreted by islets in the microphysiometer.	mwcnt	4-9	insulin	Homo sapiens	86-93
17292102-10	2005	In contrast, MWCNT-induced IL-8 release was reduced when exposed to 1% or 5% Pluronic F127 (P < .05).	mwcnt	13-18	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
34832082-2	2021	Due to its adverse effects on the environment, this study develops an effective electrochemical sensor for detecting a polyaniline-multiwalled carbon nanotube-3-aminopropyltriethoxysilane (PANI-MWCNT-APTES) substrate cast on the GCE.	mwcnt	194-199	aminomethyltransferase	Homo sapiens	229-232
31060401-8	2021	The results of qRT-PCR analysis revealed the elevated level of Cas2 mRNA in the cells treated with carboxylated MWCNT (6.08-fold) and carboxylated SWCNT (1.20-fold).	mwcnt	112-117	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	63-67
31349494-3	2019	The prepared MWCNT-PNIPAAm nanocomposite was characterized by FTIR, SEM and TGA analyses.	mwcnt	13-18	T-box transcription factor 1	Homo sapiens	76-79
31260993-5	2019	The as-synthesized MWCNT-Inulin-TiO2 bio-nanocomposite immobilized with glucose oxidase (GOx) was incorporated into the carbon paste matrix and was utilized for the sensing of glucose in food products.	mwcnt	19-24	hydroxyacid oxidase 1	Homo sapiens	72-87
31260993-5	2019	The as-synthesized MWCNT-Inulin-TiO2 bio-nanocomposite immobilized with glucose oxidase (GOx) was incorporated into the carbon paste matrix and was utilized for the sensing of glucose in food products.	mwcnt	19-24	hydroxyacid oxidase 1	Homo sapiens	89-92
29908181-5	2018	Based on these observations we hypothesized that activation of PPARgamma via administration of the PPARgamma-specific ligand rosiglitazone would limit MWCNT-induced granuloma formation and promote PPARgamma-dependent pathways.	mwcnt	151-156	peroxisome proliferator activated receptor gamma	Mus musculus	63-72
31078975-2	2019	Hence, beta-cyclodextrin (beta-CD) and poly(ethylene glycol) (PEG) host-guest complex loaded on the multi walled carbon nanotube (MWCNT/PEG/beta-CD) was prepared and characterized by Raman, NMR, TGA, XRD, SEM, TEM, and point of zero charge (pHpzc) technique.	mwcnt	130-135	T-box transcription factor 1	Homo sapiens	195-198
31012781-7	2019	MWCNT-induced lipid accumulation in THP-1 macrophages was decreased modestly by antioxidant N-acetyl-l-cysteine and more effectively by ER stress inhibitor 4-phenylbutyric acid.	mwcnt	0-5	GLI family zinc finger 2	Homo sapiens	36-41
31012781-10	2019	In conclusion, this study suggested that MWCNT exposure could promote lipid accumulation in THP-1 macrophages, which could be related to the modulation of ER stress leading to upregulation of scavenger receptors.	mwcnt	41-46	GLI family zinc finger 2	Homo sapiens	92-97
30317900-10	2018	These findings indicate that a combination of p53 deficiency and physicochemical characteristics including nanotube geometry are factors in susceptibility to MWCNT-induced lymphoid infiltration and granuloma formation.	mwcnt	158-163	transformation related protein 53, pseudogene	Mus musculus	46-49
30081225-5	2018	MWCNT-exposure resulted in increased coronary ROS production with concurrent increases in expression of LOX-1, VCAM-1, TNF-alpha, and MMP-2/9 activity; while ABCA-1 expression was downregulated, compared to FA-Controls.	mwcnt	0-5	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	104-109
30081225-5	2018	MWCNT-exposure resulted in increased coronary ROS production with concurrent increases in expression of LOX-1, VCAM-1, TNF-alpha, and MMP-2/9 activity; while ABCA-1 expression was downregulated, compared to FA-Controls.	mwcnt	0-5	vascular cell adhesion molecule 1	Mus musculus	111-117
30081225-5	2018	MWCNT-exposure resulted in increased coronary ROS production with concurrent increases in expression of LOX-1, VCAM-1, TNF-alpha, and MMP-2/9 activity; while ABCA-1 expression was downregulated, compared to FA-Controls.	mwcnt	0-5	tumor necrosis factor	Mus musculus	119-128
30081225-5	2018	MWCNT-exposure resulted in increased coronary ROS production with concurrent increases in expression of LOX-1, VCAM-1, TNF-alpha, and MMP-2/9 activity; while ABCA-1 expression was downregulated, compared to FA-Controls.	mwcnt	0-5	matrix metallopeptidase 2	Mus musculus	134-141
30081225-5	2018	MWCNT-exposure resulted in increased coronary ROS production with concurrent increases in expression of LOX-1, VCAM-1, TNF-alpha, and MMP-2/9 activity; while ABCA-1 expression was downregulated, compared to FA-Controls.	mwcnt	0-5	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	158-164
30741559-6	2019	PPARgamma-KO mice receiving MWCNT + ESAT-6 had increased granulomas and significantly elevated fibrosis (trichrome staining) compared with wild-type mice or PPARgamma-KO mice that received only MWCNT.	mwcnt	28-33	peroxisome proliferator activated receptor gamma	Mus musculus	0-9
30741559-8	2019	Analyses of BAL fluid proteins indicated increased levels of transforming growth factor (TGF)-beta and the TGF-beta pathway mediator IL-13 in PPARgamma-KO mice that received MWCNT + ESAT-6 compared with wild-type or PPARgamma-KO mice that received MWCNT.	mwcnt	174-179	transforming growth factor, beta 1	Mus musculus	89-98
30741559-8	2019	Analyses of BAL fluid proteins indicated increased levels of transforming growth factor (TGF)-beta and the TGF-beta pathway mediator IL-13 in PPARgamma-KO mice that received MWCNT + ESAT-6 compared with wild-type or PPARgamma-KO mice that received MWCNT.	mwcnt	174-179	transforming growth factor, beta 1	Mus musculus	107-115
30741559-8	2019	Analyses of BAL fluid proteins indicated increased levels of transforming growth factor (TGF)-beta and the TGF-beta pathway mediator IL-13 in PPARgamma-KO mice that received MWCNT + ESAT-6 compared with wild-type or PPARgamma-KO mice that received MWCNT.	mwcnt	174-179	interleukin 13	Mus musculus	133-138
30741559-8	2019	Analyses of BAL fluid proteins indicated increased levels of transforming growth factor (TGF)-beta and the TGF-beta pathway mediator IL-13 in PPARgamma-KO mice that received MWCNT + ESAT-6 compared with wild-type or PPARgamma-KO mice that received MWCNT.	mwcnt	174-179	peroxisome proliferator activated receptor gamma	Mus musculus	142-151
29908181-5	2018	Based on these observations we hypothesized that activation of PPARgamma via administration of the PPARgamma-specific ligand rosiglitazone would limit MWCNT-induced granuloma formation and promote PPARgamma-dependent pathways.	mwcnt	151-156	peroxisome proliferator activated receptor gamma	Mus musculus	99-108
29908181-5	2018	Based on these observations we hypothesized that activation of PPARgamma via administration of the PPARgamma-specific ligand rosiglitazone would limit MWCNT-induced granuloma formation and promote PPARgamma-dependent pathways.	mwcnt	151-156	peroxisome proliferator activated receptor gamma	Mus musculus	99-108
29440327-11	2018	CONCLUSION: The associations between MWCNT exposure and ICAM-1 indicate endothelial activation and an increased inflammatory state in workers with MWCNT exposure.	mwcnt	37-42	intercellular adhesion molecule 1	Homo sapiens	56-62
29440327-11	2018	CONCLUSION: The associations between MWCNT exposure and ICAM-1 indicate endothelial activation and an increased inflammatory state in workers with MWCNT exposure.	mwcnt	147-152	intercellular adhesion molecule 1	Homo sapiens	56-62
28128526-5	2017	MWCNT induced in a time- and dose-dependent manner the expression of TSP-1.	mwcnt	0-5	thrombospondin 1	Homo sapiens	69-74
29466008-1	2018	In the present report, we focused on the study of the out-of-plane electrical transport of multiwalled carbon nanotube (MWCNT)-doped poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) composites (PEDOT:PSS-MWCNTs) as electrodes for solar cell applications.	mwcnt	120-125	PSS	Homo sapiens	208-211
29356529-8	2018	The combined results of structural characterizatrion by Raman spectroscopy, cure characteristics, mechanical properties, and scanning and transmission electron microscopy (SEM, TEM) confirm the role of ionic liquid modified MWCNT as a reinforcing agent in the present system.	mwcnt	224-229	MFT2	Homo sapiens	177-180
28595626-7	2017	RESULTS: OPN was highly and persistently induced in both the acute and chronic phases of the response to MWCNT exposure in mouse lungs.	mwcnt	105-110	secreted phosphoprotein 1	Mus musculus	9-12
28903780-8	2017	MWCNT-induced acute inflammation was suppressed in IL-1R1 KO mice at the 24 h time point relative to WT mice, but this suppression was not observed 28 days post exposure, and IL-1R1 KO did not alter fibrotic disease development.	mwcnt	0-5	interleukin 1 receptor, type I	Mus musculus	51-57
28024456-7	2017	In WT mice exposed to MWCNT, skeletal muscle TSP-1 protein increased > fivefold compared to Sham exposed, and exhibited a 39% and 47% decrease in endothelium-dependent and -independent vasodilation, respectively.	mwcnt	22-27	thrombospondin 1	Mus musculus	45-50
26801584-8	2016	MWCNT exposure induced MMP-9 protein levels in both bronchoalveolar lavage and whole lung lysates.	mwcnt	0-5	matrix metallopeptidase 9	Mus musculus	23-28
27287127-4	2016	The cellular uptake results of transferrin conjugated MWCNT showed higher efficiency in comparison with free C6.	mwcnt	54-59	transferrin	Homo sapiens	31-42
27287127-5	2016	The IC50 values demonstrated that the transferrin conjugated MWCNT could be 136-fold more efficient than Docel  after 24h treatment with the A549 cells.	mwcnt	61-66	transferrin	Homo sapiens	38-49
27287127-6	2016	Flow cytometry analysis confirmed that cancerous cells appeared significantly (P<0.05) in the sub-G1 phase for transferrin conjugated MWCNT in comparison with Docel .	mwcnt	137-142	transferrin	Homo sapiens	114-125
27251132-4	2016	It is known that MWCNT exposure induces EMT through the activation of the TGF-beta/Smad signalling pathway thus promoting pulmonary fibrosis, but the molecular mechanisms involved are not fully understood.	mwcnt	17-22	transforming growth factor beta 1	Homo sapiens	74-82
27130136-1	2016	A highly-sensitive glucose biosensor amenable to ultraminiaturisation was fabricated by immobilization of glucose oxidase (GOX), onto a poly(2,6-diaminopyridine)/multi-walled carbon nanotube/glassy carbon electrode (poly(2,6-DP)/MWCNT/GCE).	mwcnt	229-234	hydroxyacid oxidase 1	Homo sapiens	106-121
27130136-1	2016	A highly-sensitive glucose biosensor amenable to ultraminiaturisation was fabricated by immobilization of glucose oxidase (GOX), onto a poly(2,6-diaminopyridine)/multi-walled carbon nanotube/glassy carbon electrode (poly(2,6-DP)/MWCNT/GCE).	mwcnt	229-234	hydroxyacid oxidase 1	Homo sapiens	123-126
27130136-5	2016	The GOx/poly(2,6-DP)/MWCNT/GC bioelectrode exhibited two linear responses to glucose in the concentration ranging from 0.42muM to 8.0 mM with a correlation coefficient of 0.95, sensitivity of 52.0muAmM-1cm-2, repeatability of 1.6% and long-term stability, which could make it a promising bioelectrode for precise detection of glucose in the biological samples.	mwcnt	21-26	hydroxyacid oxidase 1	Homo sapiens	4-7
26952453-1	2016	Poly-Alizarin red S/multiwalled carbon nanotube film on the surface of glassy carbon electrode (poly-AzrS/MWCNT/GCE) was synthesized by electrochemical process and was used for the sensitive and selective determination of dopamine (DA) by employing voltammetric techniques.	mwcnt	106-111	aminomethyltransferase	Homo sapiens	112-115
27026438-8	2016	The release of HMGB1 and double-stranded DNA (dsDNA) into the culture supernatant from MWCNT-treated cells was examined by ELISA and fluorometric analysis, respectively.	mwcnt	87-92	high mobility group box 1	Homo sapiens	15-20
26652440-2	2016	The ZnO nanoparticles and multi-walled carbon nanotubes modified CPE (ZnO-MWCNT/CPE) electrode was prepared by incorporation of the ZnO nanoparticles and multi-walled carbon nanotubes (MWCNT) in carbon paste electrode.	mwcnt	74-79	carboxypeptidase E	Homo sapiens	65-68
26067756-6	2016	MWCNT exposure significantly increased THP-1 monocyte adhesion to HUVECs, and co-exposure to PA aggravated the NM400-mediated adhesion but decreased the NM402-mediated adhesion.	mwcnt	0-5	GLI family zinc finger 2	Homo sapiens	39-44
26589480-8	2016	Serum concentrations of soluble gp130 decreased, aortic endothelial expression of gp130 increased, and expression of gp130 in the lung was downregulated in the MWCNT-exposed group.	mwcnt	160-165	interleukin 6 cytokine family signal transducer	Rattus norvegicus	32-37
26589480-8	2016	Serum concentrations of soluble gp130 decreased, aortic endothelial expression of gp130 increased, and expression of gp130 in the lung was downregulated in the MWCNT-exposed group.	mwcnt	160-165	interleukin 6 cytokine family signal transducer	Rattus norvegicus	82-87
26589480-8	2016	Serum concentrations of soluble gp130 decreased, aortic endothelial expression of gp130 increased, and expression of gp130 in the lung was downregulated in the MWCNT-exposed group.	mwcnt	160-165	interleukin 6 cytokine family signal transducer	Rattus norvegicus	82-87
26589480-9	2016	We propose that pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements.	mwcnt	38-43	interleukin 6 cytokine family signal transducer	Rattus norvegicus	115-120
26504962-3	2015	The results has shown that NAC participates in Michael type addition reaction with electrogenerated quinone from electrooxidation of 4-chlorocatechol at MWCNT/GCE to form the corresponding thioquinone derivative.	mwcnt	153-158	X-linked Kx blood group	Homo sapiens	27-30
26091108-9	2015	IL-4 or IL-13 decreased MWCNT-induced IL-1beta secretion by THP-1 cells and reduced pro-caspase-1 but not pro-IL-1beta.	mwcnt	24-29	interleukin 4	Homo sapiens	0-4
26091108-9	2015	IL-4 or IL-13 decreased MWCNT-induced IL-1beta secretion by THP-1 cells and reduced pro-caspase-1 but not pro-IL-1beta.	mwcnt	24-29	interleukin 13	Homo sapiens	8-13
26091108-9	2015	IL-4 or IL-13 decreased MWCNT-induced IL-1beta secretion by THP-1 cells and reduced pro-caspase-1 but not pro-IL-1beta.	mwcnt	24-29	interleukin 1 beta	Homo sapiens	38-46
26091108-13	2015	MWCNT exposure after HDM sensitization increased total cell numbers in BALF, but decreased numbers of neutrophils and IL-1beta in BALF as well as reduced pro-caspase-1 in lung tissue.	mwcnt	0-5	interleukin 1 beta	Mus musculus	118-126
26091108-13	2015	MWCNT exposure after HDM sensitization increased total cell numbers in BALF, but decreased numbers of neutrophils and IL-1beta in BALF as well as reduced pro-caspase-1 in lung tissue.	mwcnt	0-5	caspase 1	Homo sapiens	158-167
26091108-15	2015	CONCLUSIONS: These data indicate that Th2 cytokines suppress MWCNT-induced inflammasome activation via STAT6-dependent down-regulation of pro-caspase-1 and suggest that suppression of inflammasome activation and IL-1beta by an allergic lung microenvironment is a mechanism through which MWCNTs exacerbate allergen-induced airway fibrosis.	mwcnt	61-66	signal transducer and activator of transcription 6	Mus musculus	103-108
26091108-15	2015	CONCLUSIONS: These data indicate that Th2 cytokines suppress MWCNT-induced inflammasome activation via STAT6-dependent down-regulation of pro-caspase-1 and suggest that suppression of inflammasome activation and IL-1beta by an allergic lung microenvironment is a mechanism through which MWCNTs exacerbate allergen-induced airway fibrosis.	mwcnt	61-66	caspase 1	Homo sapiens	142-151
26091108-15	2015	CONCLUSIONS: These data indicate that Th2 cytokines suppress MWCNT-induced inflammasome activation via STAT6-dependent down-regulation of pro-caspase-1 and suggest that suppression of inflammasome activation and IL-1beta by an allergic lung microenvironment is a mechanism through which MWCNTs exacerbate allergen-induced airway fibrosis.	mwcnt	61-66	interleukin 1 beta	Mus musculus	212-220
24983895-7	2015	MWCNT exposure increased extracellular HMGB1 levels in primary alveolar macrophages from C57Bl/6 mice and C10 mouse epithelial cell culture supernatants, and in C57Bl/6 mouse lung lavage fluid.	mwcnt	0-5	high mobility group box 1	Mus musculus	39-44
24983895-8	2015	MWCNT-induced HMGB1 secretion was dependent upon caspase-1.	mwcnt	0-5	high mobility group box 1	Mus musculus	14-19
24983895-8	2015	MWCNT-induced HMGB1 secretion was dependent upon caspase-1.	mwcnt	0-5	caspase 1	Mus musculus	49-58
25262340-1	2015	In this work, a novel amperometric biosensor of hydrogen peroxide (H2O2) was developed based on the immobilization of myoglobin (Mb) on the surface of the multi-walled carbon nanotube (MWCNT) -Nafion-cysteamine (CA) modified gold electrode (Au) and its electrocatalytic activity was used for the determination of nitrite (NO2(-)).	mwcnt	185-190	myoglobin	Homo sapiens	118-127
28962343-5	2015	We interpret that MWCNT induces inflammation, fibrosis and granuloma characterized by progressive elevation of TNF-alpha and IL-4.	mwcnt	18-23	tumor necrosis factor	Rattus norvegicus	111-120
28962343-5	2015	We interpret that MWCNT induces inflammation, fibrosis and granuloma characterized by progressive elevation of TNF-alpha and IL-4.	mwcnt	18-23	interleukin 4	Rattus norvegicus	125-129
24915862-7	2014	RESULTS: MWCNT induced NLRP3 inflammasome dependent pyroptosis in HBE cells in a time- and dose-dependent manner.	mwcnt	9-14	NLR family pyrin domain containing 3	Homo sapiens	23-28
25265050-12	2014	Moreover, decreases in IL-2 expression in T-lymphocytes may be critical to the potential reductions in anti-tumor responses in MWCNT-exposed hosts.	mwcnt	127-132	interleukin 2	Rattus norvegicus	23-27
25175192-7	2014	The medium collected after incubation with drug-incorporated CPC with or without MWCNT inhibited TNFalpha-induced NF-kappaB activation indicating that the effective amount of MG132 was released.	mwcnt	81-86	tumor necrosis factor	Mus musculus	97-105
24530353-8	2014	Taken together, both in vivo and in vitro study demonstrated that respiratory exposure to MWCNT induced length dependent pulmonary fibrosis and epithelial-derived fibroblasts via TGF-beta/Smad pathway.	mwcnt	90-95	transforming growth factor, beta 1	Mus musculus	179-187
24502429-8	2014	Aerosolized methacholine increased parameters of airway resistance (R and Rn) in a dose-dependent manner in all groups, with MWCNT-instilled C57BL/6 mice responding more robustly compared to the controls, while no differences were found in IL-33(-/-) mice due to MWCNT exposure.	mwcnt	125-130	interleukin 33	Mus musculus	240-245
24431218-3	2014	The ApoE(-/-) mice had accelerated plaque progression in aorta after 5 intracheal instillations of MWCNT (25.6 mug/mouse weekly for 5 weeks).	mwcnt	99-104	apolipoprotein E	Mus musculus	4-8
23343389-6	2013	Based on such observations we hypothesized that PPARgamma expression would be repressed in alveolar macrophages from animals bearing granulomas induced by MWCNT instillation.	mwcnt	155-160	peroxisome proliferator activated receptor gamma	Mus musculus	48-57
24054652-1	2013	In this paper, poly(1,5-diaminonaphthalene) was interpenetrated into the network made of multiwalled carbon nanotubes (MWCNT) on platinum interdigital electrode (IDE) by electro-polymerization of 1,5-diaminonaphthalene (1,5-DAN).	mwcnt	119-124	NBL1, DAN family BMP antagonist	Homo sapiens	224-227
23642096-4	2013	We postulated that COX-2-deficient (COX-2(-/-)) mice would be susceptible to MWCNT-induced exacerbations of allergen-induced airway remodeling, including airway inflammation, fibrosis, and mucus-cell metaplasia (i.e., the formation of goblet cells).	mwcnt	77-82	prostaglandin-endoperoxide synthase 2	Mus musculus	19-24
23642096-4	2013	We postulated that COX-2-deficient (COX-2(-/-)) mice would be susceptible to MWCNT-induced exacerbations of allergen-induced airway remodeling, including airway inflammation, fibrosis, and mucus-cell metaplasia (i.e., the formation of goblet cells).	mwcnt	77-82	prostaglandin-endoperoxide synthase 2	Mus musculus	36-41
22686327-6	2013	MWCNT exposure resulted in elevated levels of IL-33 in the lavage fluid (likely originating from airway epithelial cells), enhanced AHR, eosinophil recruitment, and production of Th2-associated cytokines and chemokines.	mwcnt	0-5	interleukin 33	Mus musculus	46-51
22686327-9	2013	Collectively, our data suggest that MWCNT induce epithelial damage that results in release of IL-33, which in turn promotes innate lymphoid cell recruitment and the development of IL-13-dependent inflammatory response.	mwcnt	36-41	interleukin 33	Mus musculus	94-99
22686327-9	2013	Collectively, our data suggest that MWCNT induce epithelial damage that results in release of IL-33, which in turn promotes innate lymphoid cell recruitment and the development of IL-13-dependent inflammatory response.	mwcnt	36-41	interleukin 13	Mus musculus	180-185
22397533-5	2013	The gpt mutation frequencies significantly increased in the lungs of MWCNT-treated gpt delta transgenic mice.	mwcnt	69-74	glutamic pyruvic transaminase, soluble	Mus musculus	4-7
22397533-5	2013	The gpt mutation frequencies significantly increased in the lungs of MWCNT-treated gpt delta transgenic mice.	mwcnt	69-74	glutamic pyruvic transaminase, soluble	Mus musculus	83-86
23903001-7	2013	RESULTS: Exposure of the epithelial layer to MWCNT induced multiple changes in the endothelial cell barrier, including an increase in reactive oxygen species, actin rearrangement, loss of VE-cadherin at the cell surface, and an increase in endothelial angiogenic ability.	mwcnt	45-50	cadherin 5	Homo sapiens	188-199
28809354-3	2013	The EDC (1-ethyl-(3-dimethylaminopropyl) carbodiimide)-activated GOx was then bound covalently on the graphene- or MWCNT-modified GCE.	mwcnt	115-120	hydroxyacid oxidase 1	Homo sapiens	65-68
28809354-5	2013	However, the direct electron transfer (DET) between GOx and the modified GCE"s surface was only observed for the MWCNT-based biosensor.	mwcnt	113-118	hydroxyacid oxidase 1	Homo sapiens	52-55
23343389-9	2013	RESULTS: In wild-type mice, alveolar macrophage PPARgamma expression and activity were significantly reduced in granuloma-bearing animals 60 days after MWCNT instillation.	mwcnt	152-157	peroxisome proliferator activated receptor gamma	Mus musculus	48-57
23343389-11	2013	PPARgamma KO mice also demonstrated elevated pro-inflammatory cytokine expression in lung tissue, laser-microdissected lung granulomas, and BAL cells/fluids, at 60 days post MWCNT exposure.	mwcnt	174-179	peroxisome proliferator activated receptor gamma	Mus musculus	0-9
23216160-4	2012	MWCNT, from a variety of sources that differed primarily in overall purity and metal contaminants, were examined for their effects in vitro (toxicity and NLRP3 inflammasome activation using primary alveolar macrophages isolated from C57Bl/6 mice).	mwcnt	0-5	NLR family, pyrin domain containing 3	Mus musculus	154-159
23662055-6	2013	MWCNT elicited a significant increase in the messenger ribonucleic acid expression of cytokines in the spleen including IL-4 and IL-33, which are associated with an increase in splenic cell differentiation (CD)4(+) and CD8(+) T-cells in C57BL/6 mice following iv injection.	mwcnt	0-5	interleukin 4	Mus musculus	120-124
23662055-6	2013	MWCNT elicited a significant increase in the messenger ribonucleic acid expression of cytokines in the spleen including IL-4 and IL-33, which are associated with an increase in splenic cell differentiation (CD)4(+) and CD8(+) T-cells in C57BL/6 mice following iv injection.	mwcnt	0-5	interleukin 33	Mus musculus	129-134
21805258-8	2012	Mice that received a single administration of MWCNT showed neutrophil infiltrate and greater concentrations of tumor necrosis factor (TNF)-alpha, keratinocyte-derived chemokine (KC) and interleukin (IL)-17 in BALF when compared to controls.	mwcnt	46-51	tumor necrosis factor	Mus musculus	111-144
22812506-4	2012	Intracellular ROS levels were also measured and shown to increase significantly following exposure of the C3A to the low toxicity NMs (MWCNT and TiO(2)).	mwcnt	135-140	complement C3	Homo sapiens	106-109
23072542-10	2012	Serum levels of eotaxin were significantly elevated in the carboxylated MWCNT aspirated mice 1 day post exposure.	mwcnt	72-77	chemokine (C-C motif) ligand 11	Mus musculus	16-23
22571318-11	2012	Inhibition of iNOS (L-NAME) did not affect ERK1,2 activation, nor did L-NAME significantly decrease COX-2 induction by MWCNT.	mwcnt	119-124	prostaglandin-endoperoxide synthase 2	Mus musculus	100-105
22571318-16	2012	Our data also suggest contributory physicochemical factors other than residual Ni catalyst play a role in COX-2 induction to MWCNT.	mwcnt	125-130	prostaglandin-endoperoxide synthase 2	Mus musculus	106-111
22373798-9	2012	MWCNT-induced 8-nitroguanine formation and iNOS expression were largely suppressed by inhibitors of iNOS (1400 W), nuclear factor-kappaB (Bay11-7082), actin polymerization (cytochalasin D), caveolae-mediated endocytosis (methyl-beta-cyclodextrin, MBCD) and clathrin-mediated endocytosis (monodansylcadaverine, MDC).	mwcnt	0-5	nitric oxide synthase 2	Homo sapiens	43-47
22373798-9	2012	MWCNT-induced 8-nitroguanine formation and iNOS expression were largely suppressed by inhibitors of iNOS (1400 W), nuclear factor-kappaB (Bay11-7082), actin polymerization (cytochalasin D), caveolae-mediated endocytosis (methyl-beta-cyclodextrin, MBCD) and clathrin-mediated endocytosis (monodansylcadaverine, MDC).	mwcnt	0-5	nitric oxide synthase 2	Homo sapiens	100-104
22373798-9	2012	MWCNT-induced 8-nitroguanine formation and iNOS expression were largely suppressed by inhibitors of iNOS (1400 W), nuclear factor-kappaB (Bay11-7082), actin polymerization (cytochalasin D), caveolae-mediated endocytosis (methyl-beta-cyclodextrin, MBCD) and clathrin-mediated endocytosis (monodansylcadaverine, MDC).	mwcnt	0-5	C-C motif chemokine ligand 22	Homo sapiens	310-313
21725842-6	2011	Exposure to carboxylated functionalized MWCNT; the body-weight gain of the mice decreased, induced reactive oxygen species (ROS), and enhanced the activities of serum amino-transferases (ALT/AST), alkaline phosphatases (ALP), and concentration of lipid hydro peroxide compared to control.	mwcnt	40-45	glutamic pyruvic transaminase, soluble	Mus musculus	187-190
21725842-6	2011	Exposure to carboxylated functionalized MWCNT; the body-weight gain of the mice decreased, induced reactive oxygen species (ROS), and enhanced the activities of serum amino-transferases (ALT/AST), alkaline phosphatases (ALP), and concentration of lipid hydro peroxide compared to control.	mwcnt	40-45	transmembrane protease, serine 11d	Mus musculus	191-194
19738159-13	2010	Our data suggest that LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasing PDGF-Ralpha on pulmonary fibroblasts.	mwcnt	38-43	platelet derived growth factor receptor alpha	Rattus norvegicus	157-168
21586816-2	2011	While the room temperature hole mobility in pure MEH-PPV films was non-dispersive with positive field dependent mobility, MEH-PPV:COOH-MWCNT blended devices exhibited dispersive transport and negative field dependent mobility.	mwcnt	135-140	epoxide hydrolase 1	Homo sapiens	122-125
21246714-7	2011	MWCNT-functionalized electrodes show the ability to detect micromolar amounts of dopamine with a sensitivity of 19 nA mum(-1) .	mwcnt	0-5	PWWP domain containing 3A, DNA repair factor	Homo sapiens	118-124
20678463-1	2010	In this article, a conspicuously simple and highly sensitive amperometric immunosensor based on the sequential electrodeposition of Prussian blue (PB) and gold nanoparticles (GNPs) on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) surface is proposed for the detection of alpha-fetoprotein (AFP).	mwcnt	213-218	alpha fetoprotein	Homo sapiens	300-317
20678463-1	2010	In this article, a conspicuously simple and highly sensitive amperometric immunosensor based on the sequential electrodeposition of Prussian blue (PB) and gold nanoparticles (GNPs) on multiwalled carbon nanotube (MWCNT)-modified glassy carbon electrode (GCE) surface is proposed for the detection of alpha-fetoprotein (AFP).	mwcnt	213-218	alpha fetoprotein	Homo sapiens	319-322
20371264-6	2010	Exposure of MWCNT (10-100mug/ml) to HEK cells resulted in concentration dependent cell membrane damage (as indicated by the increased levels of LDH), increased production of IL-8, increased TBARS and decreased intracellular glutathione levels.	mwcnt	12-17	C-X-C motif chemokine ligand 8	Homo sapiens	174-178