PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19756997-7	2010	Nonylphenol and 4-octylphenol were able to suppress LPS-induced MDC and IP-10 expression.	4-octylphenol	16-29	C-C motif chemokine ligand 22	Homo sapiens	64-67
19756997-9	2010	Nonylphenol and 4-octylphenol reduced LPS-induced activation of MAPK signaling pathway, MKK1/2 and ERK, concomitant with decreased levels of LPS-induced acetylated histone 4 (H4) at the IP-10 and MDC gene loci.	4-octylphenol	16-29	mitogen-activated protein kinase 1	Homo sapiens	64-68
19756997-9	2010	Nonylphenol and 4-octylphenol reduced LPS-induced activation of MAPK signaling pathway, MKK1/2 and ERK, concomitant with decreased levels of LPS-induced acetylated histone 4 (H4) at the IP-10 and MDC gene loci.	4-octylphenol	16-29	mitogen-activated protein kinase 1	Homo sapiens	88-102
19756997-7	2010	Nonylphenol and 4-octylphenol were able to suppress LPS-induced MDC and IP-10 expression.	4-octylphenol	16-29	C-X-C motif chemokine ligand 10	Homo sapiens	72-77
16598818-2	2006	In the present study, we have shown that some EDC [benzophenone, p-octylphenol, and tributyltin chloride (TBT)] promoted strong Th2 polarization via suppression and augmentation of Th1 and Th2 development, respectively, from naive CD4+ T cells primed with anti-CD3 and splenic antigen-presenting cells (APC).	4-octylphenol	65-78	heart and neural crest derivatives expressed 2	Mus musculus	128-131
19756997-9	2010	Nonylphenol and 4-octylphenol reduced LPS-induced activation of MAPK signaling pathway, MKK1/2 and ERK, concomitant with decreased levels of LPS-induced acetylated histone 4 (H4) at the IP-10 and MDC gene loci.	4-octylphenol	16-29	H4 histone 16	Homo sapiens	164-177
19756997-9	2010	Nonylphenol and 4-octylphenol reduced LPS-induced activation of MAPK signaling pathway, MKK1/2 and ERK, concomitant with decreased levels of LPS-induced acetylated histone 4 (H4) at the IP-10 and MDC gene loci.	4-octylphenol	16-29	C-X-C motif chemokine ligand 10	Homo sapiens	186-191
19756997-9	2010	Nonylphenol and 4-octylphenol reduced LPS-induced activation of MAPK signaling pathway, MKK1/2 and ERK, concomitant with decreased levels of LPS-induced acetylated histone 4 (H4) at the IP-10 and MDC gene loci.	4-octylphenol	16-29	C-C motif chemokine ligand 22	Homo sapiens	196-199
19756997-10	2010	Nonylphenol and 4-octylphenol suppressed LPS-induced MDC expression in monocytes via, at least in part, the MKK1/2-ERK MAPK pathway and histone H4 acetylation, but not the estrogen receptor.	4-octylphenol	16-29	C-C motif chemokine ligand 22	Homo sapiens	53-56
19756997-10	2010	Nonylphenol and 4-octylphenol suppressed LPS-induced MDC expression in monocytes via, at least in part, the MKK1/2-ERK MAPK pathway and histone H4 acetylation, but not the estrogen receptor.	4-octylphenol	16-29	mitogen-activated protein kinase kinase 1	Homo sapiens	108-112
19756997-10	2010	Nonylphenol and 4-octylphenol suppressed LPS-induced MDC expression in monocytes via, at least in part, the MKK1/2-ERK MAPK pathway and histone H4 acetylation, but not the estrogen receptor.	4-octylphenol	16-29	mitogen-activated protein kinase 1	Homo sapiens	115-118
19756997-10	2010	Nonylphenol and 4-octylphenol suppressed LPS-induced MDC expression in monocytes via, at least in part, the MKK1/2-ERK MAPK pathway and histone H4 acetylation, but not the estrogen receptor.	4-octylphenol	16-29	mitogen-activated protein kinase 1	Homo sapiens	119-123
18625249-8	2008	4-n-Octylphenol and 4-tert-octylphenol were both glucuronidated by a UDP-glucuronosyltransferase isoform, UGT2B1, expressed in the liver.	4-octylphenol	0-15	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	106-112
17015962-3	2006	Alachlor, benomyl, bisphenol A, carbaryl, kelthane, kepone, octachlorostyrene, pentachlorophenol, nonyl phenol, p-octylphenol and ziram inhibited both LPS- and Pam3CSK4-induced activation of NF-kappaB.	4-octylphenol	112-125	nuclear factor kappa B subunit 1	Homo sapiens	191-200
16598818-2	2006	In the present study, we have shown that some EDC [benzophenone, p-octylphenol, and tributyltin chloride (TBT)] promoted strong Th2 polarization via suppression and augmentation of Th1 and Th2 development, respectively, from naive CD4+ T cells primed with anti-CD3 and splenic antigen-presenting cells (APC).	4-octylphenol	65-78	negative elongation factor complex member C/D, Th1l	Mus musculus	181-184
16598818-2	2006	In the present study, we have shown that some EDC [benzophenone, p-octylphenol, and tributyltin chloride (TBT)] promoted strong Th2 polarization via suppression and augmentation of Th1 and Th2 development, respectively, from naive CD4+ T cells primed with anti-CD3 and splenic antigen-presenting cells (APC).	4-octylphenol	65-78	heart and neural crest derivatives expressed 2	Mus musculus	189-192
16598818-7	2006	Collectively these results suggest that EDC such as benzophenone, p-octylphenol, and TBT promote Th2 polarization indirectly via the depletion of glutathione in APC and subsequent modulation of IL-10 and IL-12 production that might result in the exacerbation of allergic diseases.	4-octylphenol	66-79	heart and neural crest derivatives expressed 2	Mus musculus	97-100
16598818-7	2006	Collectively these results suggest that EDC such as benzophenone, p-octylphenol, and TBT promote Th2 polarization indirectly via the depletion of glutathione in APC and subsequent modulation of IL-10 and IL-12 production that might result in the exacerbation of allergic diseases.	4-octylphenol	66-79	interleukin 10	Mus musculus	194-199
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-octylphenol	47-62	negative elongation factor complex member C/D, Th1l	Mus musculus	81-84
16617682-8	2005	Furthermore non-halogenated compounds among these phenolic compounds, such as BPA, p-octylphenol, and p-nonylphenol, showed inhibitory effects on the isomerase activity of PDI.	4-octylphenol	83-96	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	172-175
16169144-4	2005	We investigated BPA, 4-octylphenol (OP) and 4-nonylphenol (NP) for their agonistic and antagonistic activities by the AR reporter gene assay.	4-octylphenol	21-34	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	118-120
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-octylphenol	47-62	heart and neural crest derivatives expressed 2	Mus musculus	109-112
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-octylphenol	47-62	progesterone receptor	Mus musculus	189-193
15234545-13	2004	These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR.	4-octylphenol	47-62	nuclear receptor subfamily 3, group C, member 1	Mus musculus	199-202
33082440-4	2020	Triclosan (an antimicrobial agent) and 4-octylphenol (a plasticizer) were only detected in the tap water (up to 9.74 and 0.44 ng/L, respectively).	4-octylphenol	39-52	nuclear RNA export factor 1	Homo sapiens	95-98
12117780-1	2002	Experiments were conducted to determine whether the natural estrogen and an environmental compound with estrogenic action, 4-n-octylphenol (4nOP), could modify tumor development in human c-Ha-ras proto-oncogene transgenic (Tg) rats which are highly susceptible to mammary and skin carcinogens.	4-octylphenol	123-138	prepronociceptin	Homo sapiens	141-144
11971643-7	2002	The PCNA indices in adenocarcinomas, hyperplastic lesions, and nonlesional glands in rats treated with DMAB and 4-n-octylphenol were slightly lower than that of the DMAB alone group, but the differences were not statistically significant.	4-octylphenol	112-127	proliferating cell nuclear antigen	Rattus norvegicus	4-8
33780895-0	2021	Binding mechanism of 4-octylphenol with human serum albumin: Spectroscopic investigations, molecular docking and dynamics simulation.	4-octylphenol	21-34	albumin	Homo sapiens	46-59
15081833-11	2004	The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta.	4-octylphenol	29-42	estrogen receptor	Ictalurus punctatus	116-132
15081833-11	2004	The alkylphenolic compounds (4-octylphenol and 4-nonylphenol) displayed some ability to displace 3H-E2 binding from ERalpha and beta at high concentrations, but dieldrin and atrazine had little binding activity for both ER subtypes and endosulfan for ERbeta.	4-octylphenol	29-42	estrogen receptor beta	Ictalurus punctatus	251-257
12547330-1	2003	In this study, we tested phenolic compounds such as bisphenol A (BPA), 4-nonylphenol (NP), 4-octylphenol (OP) and 4-propylphenol (PP) by using glucose-6-phosphate dehydrogenase (G6PD) in estrogen sensitive human breast cancer cells (MCF-7 cells) and glutathione peroxidase (GPx) in female immature Sprague-Dawley (SD) rats.	4-octylphenol	91-104	glucose-6-phosphate dehydrogenase	Homo sapiens	143-176
9099904-2	1997	We have assessed whether expression of SF-1 in the gonads of rat fetuses was altered following maternal treatment with diethylstilbestrol (DES, a synthetic oestrogen) or 4-octylphenol (OP, a xenoestrogen).	4-octylphenol	170-183	splicing factor 1	Rattus norvegicus	39-43
31345089-7	2019	Western blotting revealed that 4-OP induced caspase-3 activity and Bad phosphorylation in a concentration- and time-dependent manner.	4-octylphenol	31-35	caspase 3	Mus musculus	44-53
27297103-4	2016	hSPCA2 activity was inhibited by thapsigargin, 2,2"-methylenebis(6-tert-butyl-p-cresol), and 4-octylphenol in the low-micromolar concentration range.	4-octylphenol	93-106	ATPase secretory pathway Ca2+ transporting 2	Homo sapiens	0-6
30925854-0	2019	Identification of in vitro effect of 4-octylphenol on the basal and human chorionic gonadotropin (hCG) stimulated secretion of androgens and superoxide radicals in mouse Leydig cells.	4-octylphenol	37-50	chorionic gonadotropin subunit beta 5	Homo sapiens	98-101
30925854-1	2019	The aim of our in vitro study was to assess the potential effect of 4-octylphenol (4-OP) on the basal and human chorionic gonadotropin (hCG)-stimulated cholesterol levels and biosynthesis of steroid hormones in cultured mouse Leydig cells.	4-octylphenol	68-81	chorionic gonadotropin subunit beta 5	Homo sapiens	136-139
26970590-5	2016	Furthermore, an interaction between GSTM1 and 4-n-octylphenol (4-n-OP) was identified (Pinter=7.00x10(-3)), as well as a 2-order interaction among GSTT1, GSTM1 and 4-n-OP (Pinter=0.04).	4-octylphenol	46-61	glutathione S-transferase mu 1	Homo sapiens	36-41
26970590-5	2016	Furthermore, an interaction between GSTM1 and 4-n-octylphenol (4-n-OP) was identified (Pinter=7.00x10(-3)), as well as a 2-order interaction among GSTT1, GSTM1 and 4-n-OP (Pinter=0.04).	4-octylphenol	63-69	glutathione S-transferase mu 1	Homo sapiens	36-41
26970590-6	2016	Subjects with GSTT1-present and GSTM1-null genotypes were susceptible to male infertility when exposed to 4-n-OP (OR=14.05, 95% CI=4.78-60.20, P=2.34x10(-5)).	4-octylphenol	106-112	glutathione S-transferase theta 1	Homo sapiens	14-19
26970590-6	2016	Subjects with GSTT1-present and GSTM1-null genotypes were susceptible to male infertility when exposed to 4-n-OP (OR=14.05, 95% CI=4.78-60.20, P=2.34x10(-5)).	4-octylphenol	106-112	glutathione S-transferase mu 1	Homo sapiens	32-37