PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34030412-6	2021	Correlation analysis shows the correlation between TP and RP was higher than that between EP and RP, indicating that the removal efficiency is mainly affected by the fraction transformation of HMs.	Metals, Heavy	193-196	epiregulin	Homo sapiens	90-92
35162084-2	2022	In order to solve this problem, a new functional material beta-cyclodextrin modified biochar (beta-CD-BC) was prepared by integrating the properties of biochar (BC) and the hydrophilic and hydrophobic properties of the beta-CD surface and combined with Portland cement (PC) to cure and stabilize HMs and PHe.	Metals, Heavy	296-299	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	219-226
33453669-4	2021	The Langmuir isotherm model showed that the adsorption capacity of the hydrogel for Pb(II) and Ni(II) reached 505.9 mg/g and 286.7 mg/g, respectively, and the efficiency of removing the low-concentration heavy metal ions in water more than 99%.	Metals, Heavy	204-215	submaxillary gland androgen regulated protein 3B	Homo sapiens	84-90
28110170-7	2017	Furthermore, HMs mediated Trp2/CpG delivery system greatly expands antigen specific cytotoxic T lymphocytes (CTLs) and offers a strong anti-tumor effect in a lung metastatic melanoma model.	Metals, Heavy	13-16	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	26-30
33285374-2	2021	CaO is an active component in fly ash to adsorb heavy metal species.	Metals, Heavy	48-59	mummy	Drosophila melanogaster	0-3
30499096-9	2019	Furthermore, considering the resistant nature of C2 and C3 constituents along with their significant quenching effects for the four target HMs, the concentrations of humic-like constituents in urban forestland soil may be a useful parameter to evaluate the potential risk of HMs immobilization and transformation.	Metals, Heavy	139-142	complement C2	Homo sapiens	49-58
28353172-6	2017	The BET surface area of HMS was evaluated by nitrogen adsorption/desorption analysis.	Metals, Heavy	24-27	delta/notch like EGF repeat containing	Homo sapiens	4-7
33957582-10	2021	The high abundance of integrase genes and ARGs and their reciprocal correlations with HMs pose a serious risk of the rapid spread of antibiotic resistance in the environment.	Metals, Heavy	86-89	serpin family A member 2 (gene/pseudogene)	Homo sapiens	42-46
33790056-11	2021	Conclusions: UD EGC with positive HMs after ER may have favorable long-term outcomes and a very low risk of LN metastasis.	Metals, Heavy	34-37	epiregulin	Homo sapiens	44-46
33604960-3	2021	To circumvent this shortcoming, the common practice has been to utilize the large SOC of nonmagnetic layers of 5d heavy metals (HMs), such as Pt, to generate spin currents and, in turn, exert spin torques on the magnetic layers.	Metals, Heavy	128-131	spindlin 1	Homo sapiens	158-162
33604960-3	2021	To circumvent this shortcoming, the common practice has been to utilize the large SOC of nonmagnetic layers of 5d heavy metals (HMs), such as Pt, to generate spin currents and, in turn, exert spin torques on the magnetic layers.	Metals, Heavy	128-131	spindlin 1	Homo sapiens	192-196
33333381-8	2021	Thus, the lack of negative long-term effects confirms the feasibility and safety of using SSB in agricultural areas with regards to contamination by HM, and makes it an alternative for the disposal of domestic SS.	Metals, Heavy	149-151	small RNA binding exonuclease protection factor La	Homo sapiens	90-93
32175494-6	2020	Only 2.7% PO selectivity with a propylene conversion of 10.1% was achieved over the AgMo/HMS sample.	Metals, Heavy	89-92	alkylglycerol monooxygenase	Homo sapiens	84-88
32175494-10	2020	However, during the reaction of C3H6 with AgMo/HMS, the formation of this intermediate was hardly detected.	Metals, Heavy	47-50	alkylglycerol monooxygenase	Homo sapiens	42-46
31756223-7	2019	Both HMs induced nuclear activation of Nrf2, presumably to increase transcription of antioxidant responsive genes to combat oxidative stress.	Metals, Heavy	5-8	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
31756223-8	2019	Incubation of osteoblasts with HMs also compromised the secretion of procollagen type 1, osteocalcin, and alkaline phosphatase.	Metals, Heavy	31-34	bone gamma-carboxyglutamate protein	Homo sapiens	89-100
29627928-4	2018	HM deposition decreases seedling size and mass and reduces activities of the chlorophyll family, photosynthesis enzymes (RuBP and PEPC), and photosynthesis efficiency.	Metals, Heavy	0-2	phosphoenolpyruvate carboxylase 2	Triticum aestivum	130-134
12917481-7	2003	Kinetics of PrP(res) disappearance in vitro and unaffected PrP(C) levels during treatment suggest that HMs are able to block the conversion of PrP(C) into PrP(res).	Metals, Heavy	103-106	prion protein	Mus musculus	12-15
27920298-5	2017	Although both enzymes catalyze the same reactions, hMS was previously proposed to preferentially catalyze the formation of malate from acetyl-CoA and glyoxylate (malate synthase activity) and hMCL was proposed to primarily cleave beta-methylmalyl-CoA to propionyl-CoA and glyoxylate.	Metals, Heavy	51-54	C-type lectin domain family 4 member D	Homo sapiens	192-196
24401707-9	2014	Overall, our data suggest long-term reduction in glycinergic drive to HMs results in changes in intrinsic and synaptic properties that are consistent with homeostatic plasticity in spa and ot but not in spd.	Metals, Heavy	70-73	glycine receptor, beta subunit	Mus musculus	181-184
21391572-7	2011	In addition, the electrosynthesized PNA matrix to entrap GOx for an inhibitive assay of Ag(+) shows the lowest competitive affinity to HM ions and gives the highest sensitivity, as compared with several other polymer matrixes commonly used for the inhibitive assay.	Metals, Heavy	135-137	hydroxyacid oxidase 1	Homo sapiens	57-60
20445747-1	2010	A new method was developed for simultaneous determination of copper, lead, and cadmium, based on their voltammetric response at a carbon paste electrode modified with hexagonal mesoporous silica (HMS) immobilized quercetin (HMS-Qu/CPE).	Metals, Heavy	224-227	carboxypeptidase E	Homo sapiens	231-234
20445747-3	2010	The properties of the HMS-Qu/CPE in 0.1 M HCOONa-HCl buffer solution (pH 4.7) were investigated by adsorptive stripping voltammetry (ASV) and electrochemical impedance spectroscopy (EIS).	Metals, Heavy	22-25	carboxypeptidase E	Homo sapiens	29-32
26858822-3	2016	Fibroblast cells (NIH 3T3) and non-adherent T cells (EL4) encapsulated in HMs showed high viability and proliferation.	Metals, Heavy	74-77	epilepsy 4	Mus musculus	53-56
19475488-0	2010	Heavy metal concentrations in surface sediments from two regions (Saros and Gokova Gulfs) of the Eastern Aegean Sea.	Metals, Heavy	0-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	112-115
10925315-1	2000	The heavy metal mercury elicits a genetically restricted autoantibody response in mice that targets the nucleolar autoantigen fibrillarin.	Metals, Heavy	4-15	fibrillarin	Mus musculus	126-137
8592184-14	1995	The neuropeptide thyrotropin-releasing hormone (TRH), which also depolarizes and increases the RN of HMs, occluded the response of HMs to NE.	Metals, Heavy	101-104	thyrotropin releasing hormone	Rattus norvegicus	17-46
1479442-10	1992	Thus TRH acts directly on HMs to cause the depolarization.	Metals, Heavy	26-29	thyrotropin releasing hormone	Rattus norvegicus	5-8
8178024-2	1993	We found that TRH (0.1-10 microM) had two effects: 1) it caused depolarization of HMs and 2) decreased their input conductance.	Metals, Heavy	82-85	thyrotropin releasing hormone	Rattus norvegicus	14-17
8178024-8	1993	This suggests that in the presence of TRH, the effects of both excitatory and inhibitory synaptic inputs on HMs are enhanced and the contrast between excitation and inhibition is sharpened.	Metals, Heavy	108-111	thyrotropin releasing hormone	Rattus norvegicus	38-41
1479442-16	1992	Taken together, these results indicate that TRH depolarizes HMs, in part, by decreasing a resting K+ conductance.	Metals, Heavy	60-63	thyrotropin releasing hormone	Rattus norvegicus	44-47
34371434-2	2021	The results showed that the mean concentrations of the HMs in the sediment samples followed the order Al > Fe > Mn > Cr > Ni > Zn > Cu > Pb > As>Hg, respectively.	Metals, Heavy	55-58	general transcription factor IIE subunit 1	Homo sapiens	107-109
34604686-6	2021	HMs in a concentration range of 25-200 mug mL-1 were used throughout the study.	Metals, Heavy	0-3	L1 cell adhesion molecule	Mus musculus	43-47
35288336-4	2022	Production of reactive oxygen species and enhanced expression of the heat shock protein Hsp-16.2 was observed, indicating increased HM-mediated oxidative stress.	Metals, Heavy	132-134	Heat shock protein hsp-16.2;SHSP domain-containing protein	Caenorhabditis elegans	88-96
35288336-5	2022	Toxic effects of HM-polluted soil on worms were higher for sod-2 mutant than for N2 strain.	Metals, Heavy	17-19	Superoxide dismutase [Mn] 1, mitochondrial	Caenorhabditis elegans	59-64