PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7849064-4 1995 The cooperativity of hRPA binding to both poly(dT) and poly(dA) was found to be low (omega = 10-20) at all NaCl concentrations examined (0.3-2 M). Poly T 42-50 replication protein A1 Homo sapiens 21-25 7849064-4 1995 The cooperativity of hRPA binding to both poly(dT) and poly(dA) was found to be low (omega = 10-20) at all NaCl concentrations examined (0.3-2 M). poly(dA) 55-63 replication protein A1 Homo sapiens 21-25 7849064-4 1995 The cooperativity of hRPA binding to both poly(dT) and poly(dA) was found to be low (omega = 10-20) at all NaCl concentrations examined (0.3-2 M). Sodium Chloride 107-111 replication protein A1 Homo sapiens 21-25 7849064-5 1995 In contrast, the apparent binding affinity (K omega) of RPA decreased significantly with increasing salt concentration, such that log [NaCl]/log K omega was -2.8 for poly(dT) and -4.8 for poly(dA). Salts 100-104 replication protein A1 Homo sapiens 56-59 7849064-5 1995 In contrast, the apparent binding affinity (K omega) of RPA decreased significantly with increasing salt concentration, such that log [NaCl]/log K omega was -2.8 for poly(dT) and -4.8 for poly(dA). Sodium Chloride 135-139 replication protein A1 Homo sapiens 56-59 7849064-5 1995 In contrast, the apparent binding affinity (K omega) of RPA decreased significantly with increasing salt concentration, such that log [NaCl]/log K omega was -2.8 for poly(dT) and -4.8 for poly(dA). poly 166-170 replication protein A1 Homo sapiens 56-59 7849064-5 1995 In contrast, the apparent binding affinity (K omega) of RPA decreased significantly with increasing salt concentration, such that log [NaCl]/log K omega was -2.8 for poly(dT) and -4.8 for poly(dA). Thymidine 171-173 replication protein A1 Homo sapiens 56-59 7849064-5 1995 In contrast, the apparent binding affinity (K omega) of RPA decreased significantly with increasing salt concentration, such that log [NaCl]/log K omega was -2.8 for poly(dT) and -4.8 for poly(dA). poly 188-192 replication protein A1 Homo sapiens 56-59 7849064-5 1995 In contrast, the apparent binding affinity (K omega) of RPA decreased significantly with increasing salt concentration, such that log [NaCl]/log K omega was -2.8 for poly(dT) and -4.8 for poly(dA). amsonic acid 193-196 replication protein A1 Homo sapiens 56-59 7849064-8 1995 The apparent binding affinity (K omega) of RPA was higher for poly(dT) than for poly(dA); extrapolation of our data indicated that the apparent binding affinity at 0.2 M NaCl was 1.6 x 10(10) M-1 for poly(dT) and 1.1 x 10(9) M-1 for poly(dA). Poly T 62-70 replication protein A1 Homo sapiens 43-46 7849064-8 1995 The apparent binding affinity (K omega) of RPA was higher for poly(dT) than for poly(dA); extrapolation of our data indicated that the apparent binding affinity at 0.2 M NaCl was 1.6 x 10(10) M-1 for poly(dT) and 1.1 x 10(9) M-1 for poly(dA). poly(dA) 80-88 replication protein A1 Homo sapiens 43-46 7849064-8 1995 The apparent binding affinity (K omega) of RPA was higher for poly(dT) than for poly(dA); extrapolation of our data indicated that the apparent binding affinity at 0.2 M NaCl was 1.6 x 10(10) M-1 for poly(dT) and 1.1 x 10(9) M-1 for poly(dA). Sodium Chloride 170-174 replication protein A1 Homo sapiens 43-46 7849064-8 1995 The apparent binding affinity (K omega) of RPA was higher for poly(dT) than for poly(dA); extrapolation of our data indicated that the apparent binding affinity at 0.2 M NaCl was 1.6 x 10(10) M-1 for poly(dT) and 1.1 x 10(9) M-1 for poly(dA). poly 62-66 replication protein A1 Homo sapiens 43-46 7849064-8 1995 The apparent binding affinity (K omega) of RPA was higher for poly(dT) than for poly(dA); extrapolation of our data indicated that the apparent binding affinity at 0.2 M NaCl was 1.6 x 10(10) M-1 for poly(dT) and 1.1 x 10(9) M-1 for poly(dA). Thymidine 67-69 replication protein A1 Homo sapiens 43-46 7849064-8 1995 The apparent binding affinity (K omega) of RPA was higher for poly(dT) than for poly(dA); extrapolation of our data indicated that the apparent binding affinity at 0.2 M NaCl was 1.6 x 10(10) M-1 for poly(dT) and 1.1 x 10(9) M-1 for poly(dA). poly(dA) 233-241 replication protein A1 Homo sapiens 43-46 34390798-9 2021 The anti-inflammatory mechanism is that tanshinol and Sal B respectively targeted on PPARgamma and JNK, while Tan IIA worked on AKT1 and NGR1 bound to PI3K. salvianolic acid B 54-59 mitogen-activated protein kinase 8 Rattus norvegicus 99-102 34637797-1 2021 AIM: This study investigated the roles of bone morphogenetic protein-4 (BMP4) and ROS in diabetic endothelial dysfunction and explored whether Salvianolic acid B (Sal B) improved endothelial function by affecting BMP4-ROS in diabetic mice. salvianolic acid B 143-161 bone morphogenetic protein 4 Mus musculus 213-217 34637797-1 2021 AIM: This study investigated the roles of bone morphogenetic protein-4 (BMP4) and ROS in diabetic endothelial dysfunction and explored whether Salvianolic acid B (Sal B) improved endothelial function by affecting BMP4-ROS in diabetic mice. salvianolic acid B 163-168 bone morphogenetic protein 4 Mus musculus 213-217 34637797-8 2021 One week-treatment or 24 h-incubation with Sal B disrupted the cycle, suppressed p38 MAPK/JNK/caspase 3 cascade, and improved endothelium-dependent relaxations (EDRs) in db/db mouse aortas. salvianolic acid B 43-48 mitogen-activated protein kinase 14 Mus musculus 81-89 34637797-8 2021 One week-treatment or 24 h-incubation with Sal B disrupted the cycle, suppressed p38 MAPK/JNK/caspase 3 cascade, and improved endothelium-dependent relaxations (EDRs) in db/db mouse aortas. salvianolic acid B 43-48 mitogen-activated protein kinase 8 Mus musculus 90-93 34637797-8 2021 One week-treatment or 24 h-incubation with Sal B disrupted the cycle, suppressed p38 MAPK/JNK/caspase 3 cascade, and improved endothelium-dependent relaxations (EDRs) in db/db mouse aortas. salvianolic acid B 43-48 caspase 3 Mus musculus 94-103 34637797-10 2021 Furthermore, in vivo BMP4 overexpression induced oxidative stress, stimulated p38 MAPK/JNK/caspase 3, and impaired EDRs in db/m + mouse aortas, which were all reversed by Sal B. salvianolic acid B 171-176 bone morphogenetic protein 4 Mus musculus 21-25 34427398-5 2021 Experimental in vitro testing of highest-ranked hits identified uvaretin, saucerneol, and salvianolic acid B as active IRAK-4 inhibitors with IC50 values in low micromolar range. salvianolic acid B 90-108 interleukin 1 receptor associated kinase 4 Homo sapiens 119-125 34637797-10 2021 Furthermore, in vivo BMP4 overexpression induced oxidative stress, stimulated p38 MAPK/JNK/caspase 3, and impaired EDRs in db/m + mouse aortas, which were all reversed by Sal B. salvianolic acid B 171-176 mitogen-activated protein kinase 14 Mus musculus 78-86 34637797-10 2021 Furthermore, in vivo BMP4 overexpression induced oxidative stress, stimulated p38 MAPK/JNK/caspase 3, and impaired EDRs in db/m + mouse aortas, which were all reversed by Sal B. salvianolic acid B 171-176 mitogen-activated protein kinase 8 Mus musculus 87-90 34637797-10 2021 Furthermore, in vivo BMP4 overexpression induced oxidative stress, stimulated p38 MAPK/JNK/caspase 3, and impaired EDRs in db/m + mouse aortas, which were all reversed by Sal B. salvianolic acid B 171-176 caspase 3 Mus musculus 91-100 34637797-11 2021 SIGNIFICANCE: The present study demonstrates that Sal B ameliorates endothelial dysfunction through breaking the BMP4-ROS cycle and subsequently inhibiting p38 MAPK/JNK/caspase 3 in diabetic mice and provides evidence for the additional new mechanism underlying the benefit of Sal B against diabetic vasculopathy. salvianolic acid B 50-55 bone morphogenetic protein 4 Mus musculus 113-117 34637797-11 2021 SIGNIFICANCE: The present study demonstrates that Sal B ameliorates endothelial dysfunction through breaking the BMP4-ROS cycle and subsequently inhibiting p38 MAPK/JNK/caspase 3 in diabetic mice and provides evidence for the additional new mechanism underlying the benefit of Sal B against diabetic vasculopathy. salvianolic acid B 50-55 mitogen-activated protein kinase 14 Mus musculus 156-164 34637797-11 2021 SIGNIFICANCE: The present study demonstrates that Sal B ameliorates endothelial dysfunction through breaking the BMP4-ROS cycle and subsequently inhibiting p38 MAPK/JNK/caspase 3 in diabetic mice and provides evidence for the additional new mechanism underlying the benefit of Sal B against diabetic vasculopathy. salvianolic acid B 50-55 mitogen-activated protein kinase 8 Mus musculus 165-168 34637797-11 2021 SIGNIFICANCE: The present study demonstrates that Sal B ameliorates endothelial dysfunction through breaking the BMP4-ROS cycle and subsequently inhibiting p38 MAPK/JNK/caspase 3 in diabetic mice and provides evidence for the additional new mechanism underlying the benefit of Sal B against diabetic vasculopathy. salvianolic acid B 50-55 caspase 3 Mus musculus 169-178 34490483-0 2021 Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal-induced macrophages via inhibiting the Akt/mTOR signaling pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Homo sapiens 141-144 34490483-0 2021 Salvianolic acid B improves autophagic dysfunction and decreases the apoptosis of cholesterol crystal-induced macrophages via inhibiting the Akt/mTOR signaling pathway. salvianolic acid B 0-18 mechanistic target of rapamycin kinase Homo sapiens 145-149 34490483-5 2021 Furthermore, Sal B significantly attenuated CHC-induced release of proinflammatory factors (TNF-alpha and IL-6) by macrophages. salvianolic acid B 13-18 tumor necrosis factor Homo sapiens 92-101 34490483-5 2021 Furthermore, Sal B significantly attenuated CHC-induced release of proinflammatory factors (TNF-alpha and IL-6) by macrophages. salvianolic acid B 13-18 interleukin 6 Homo sapiens 106-110 34490483-7 2021 Furthermore, pretreatment of CHC-induced macrophages with insulin significantly decreased Sal B-induced autophagy, indicating that the Akt/mTOR signaling pathway may serve as a critical mediator in regulating Sal B-mediated cell death. salvianolic acid B 90-95 AKT serine/threonine kinase 1 Homo sapiens 135-138 34490483-7 2021 Furthermore, pretreatment of CHC-induced macrophages with insulin significantly decreased Sal B-induced autophagy, indicating that the Akt/mTOR signaling pathway may serve as a critical mediator in regulating Sal B-mediated cell death. salvianolic acid B 90-95 mechanistic target of rapamycin kinase Homo sapiens 139-143 34364877-0 2021 Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3beta signaling and preserving mitochondrial function. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 93-96 34364877-0 2021 Salvianolic acid B attenuates oxidative stress-induced injuries in enterocytes by activating Akt/GSK3beta signaling and preserving mitochondrial function. salvianolic acid B 0-18 glycogen synthase kinase 3 alpha Rattus norvegicus 97-105 34364877-7 2021 Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B. salvianolic acid B 17-22 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 34364877-7 2021 Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B. salvianolic acid B 17-22 glycogen synthase kinase 3 alpha Rattus norvegicus 82-90 34364877-7 2021 Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B. salvianolic acid B 202-207 AKT serine/threonine kinase 1 Rattus norvegicus 74-77 34364877-7 2021 Mechanistically, Sal B treatment up-regulated the phosphorylated level of Akt and GSK3beta in enterocytes in vitro and in vivo, and PI3K inhibitor LY294002 treatment abrogated the protective effects of Sal B. salvianolic acid B 202-207 glycogen synthase kinase 3 alpha Rattus norvegicus 82-90 34364877-9 2021 Together, our results demonstrated that the damage of intestinal epithelial cells in in vitro and in vivo models were both attenuated by Sal B treatment, and such antioxidant activity might very possibly be attributed to the activation of Akt/GSK3beta signaling. salvianolic acid B 137-142 AKT serine/threonine kinase 1 Rattus norvegicus 239-242 34364877-9 2021 Together, our results demonstrated that the damage of intestinal epithelial cells in in vitro and in vivo models were both attenuated by Sal B treatment, and such antioxidant activity might very possibly be attributed to the activation of Akt/GSK3beta signaling. salvianolic acid B 137-142 glycogen synthase kinase 3 alpha Rattus norvegicus 243-251 34533129-0 2021 (Salvianolic acid B promotes the proliferation, migration and osteogenic differentiation of human gingival mesenchymal stem cells by activating the PI3K/AKT pathway). salvianolic acid B 1-19 AKT serine/threonine kinase 1 Homo sapiens 153-156 34648670-6 2021 SAB also upregulated HDMEC cellular eNOS and VEGF. salvianolic acid B 0-3 vascular endothelial growth factor A Homo sapiens 45-49 34648670-7 2021 When SAB-treated HDMEC conditioned medium was transferred to HDFs, the expression of collagen I, collagen III, and elastin in HDFs was upregulated and MMP-1 was downregulated. salvianolic acid B 5-8 elastin Homo sapiens 115-122 34648670-7 2021 When SAB-treated HDMEC conditioned medium was transferred to HDFs, the expression of collagen I, collagen III, and elastin in HDFs was upregulated and MMP-1 was downregulated. salvianolic acid B 5-8 matrix metallopeptidase 1 Homo sapiens 151-156 34500674-6 2021 In conclusion, Sal B can protect against aging through regulating the Keap1/Nrf2 pathway as well as antioxidative genes and enzyme activity. salvianolic acid B 15-20 kelch-like ECH-associated protein 1a Danio rerio 70-75 34500674-6 2021 In conclusion, Sal B can protect against aging through regulating the Keap1/Nrf2 pathway as well as antioxidative genes and enzyme activity. salvianolic acid B 15-20 nfe2 like bZIP transcription factor 2a Danio rerio 76-80 34500674-0 2021 Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish. salvianolic acid B 22-27 kelch-like ECH-associated protein 1a Danio rerio 80-85 34500674-0 2021 Protective Effects of Sal B on Oxidative Stress-Induced Aging by Regulating the Keap1/Nrf2 Signaling Pathway in Zebrafish. salvianolic acid B 22-27 nfe2 like bZIP transcription factor 2a Danio rerio 86-90 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 catalase Danio rerio 161-164 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 nfe2 like bZIP transcription factor 2b Danio rerio 189-194 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 superoxide dismutase 1, soluble Danio rerio 196-200 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 superoxide dismutase 2, mitochondrial Danio rerio 202-206 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 myosin, light chain 2a, regulatory, cardiac, slow Danio rerio 208-213 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 selenium binding protein 1 Danio rerio 215-223 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 tumor protein p53 Danio rerio 225-228 34500674-4 2021 While after adding 0.05 mug/mL and 0.5 mug/mL Sal B to the ethanol-treated group, death rates and MDA levels decreased, the activity of antioxidant enzyme (SOD, CAT and GSH-Px) changed and Nrf2b, sod1, sod2, myl2a, selenbp1, p53 and p21 were down-regulated compared to the ethanol-treated group. salvianolic acid B 46-51 cyclin-dependent kinase inhibitor 1A Danio rerio 233-236 34533129-4 2021 Results The proliferation and migration ability of SalB-treated hGMSCs were significantly increased in a dose-dependent manner; the ability of osteogenic differentiation of hGMSCs and the expressions of osteogenesis associated proteins and PI3K/AKT signal pathway related proteins were up-regulated, while the adipogenic differentiation decreased, and the expression of adipogenesis related proteins was significantly down-regulated. salvianolic acid B 51-55 AKT serine/threonine kinase 1 Homo sapiens 245-248 34114895-0 2021 Salvianolic acid B noncovalently interacts with disordered c-Myc: a computational and spectroscopic-based study. salvianolic acid B 0-18 MYC proto-oncogene, bHLH transcription factor Homo sapiens 59-64 34422078-21 2021 Molecular docking analysis showed that salvianolic acid B and emodin had a good binding affinity toward Keap-1. salvianolic acid B 39-57 Kelch-like ECH-associated protein 1 Rattus norvegicus 104-110 35500448-2 2022 This study aims to explore the molecular mechanism underlying antidepressant and analgetic effect of salvianolic acid B (SalB) in comorbid pain in depression induced by chronic restraint stress (CRS), which associates with GABAergic neuron activation in the amygdala and the ERK-CREB-BDNF signaling pathway. salvianolic acid B 101-119 cAMP responsive element binding protein 1 Mus musculus 279-283 35194776-0 2022 Inhibition of chemically and mechanically activated Piezo1 channels as a mechanism for ameliorating atherosclerosis with salvianolic acid B. salvianolic acid B 121-139 piezo-type mechanosensitive ion channel component 1 Mus musculus 52-58 35194776-17 2022 CONCLUSION AND IMPLICATIONS: Our study provides novel mechanistic insights into the inhibitory role of salvianolic acid B against Piezo1 channels and improves our understanding of salvianolic acid B in preventing atherosclerotic lesions. salvianolic acid B 103-121 piezo-type mechanosensitive ion channel component 1 Mus musculus 130-136 34278114-7 2021 Among them, ginsenoside F2, protocatechuic acid, and salvianolic acid B were selected and validated to promote glucose consumption through activating AMPK phosphorylation and upregulating GLUT4 in insulin-resistant cell model (HepG2/IR) cells. salvianolic acid B 53-71 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 150-154 34278114-7 2021 Among them, ginsenoside F2, protocatechuic acid, and salvianolic acid B were selected and validated to promote glucose consumption through activating AMPK phosphorylation and upregulating GLUT4 in insulin-resistant cell model (HepG2/IR) cells. salvianolic acid B 53-71 solute carrier family 2 member 4 Homo sapiens 188-193 34278114-7 2021 Among them, ginsenoside F2, protocatechuic acid, and salvianolic acid B were selected and validated to promote glucose consumption through activating AMPK phosphorylation and upregulating GLUT4 in insulin-resistant cell model (HepG2/IR) cells. salvianolic acid B 53-71 insulin Homo sapiens 197-204 35500448-0 2022 Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism. salvianolic acid B 0-18 mitogen-activated protein kinase 1 Mus musculus 148-151 35500448-0 2022 Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism. salvianolic acid B 0-18 cAMP responsive element binding protein 1 Mus musculus 152-156 35500448-0 2022 Salvianolic acid B alleviates comorbid pain in depression induced by chronic restraint stress through inhibiting GABAergic neuron excitation via an ERK-CREB-BDNF axis-dependent mechanism. salvianolic acid B 0-18 brain derived neurotrophic factor Mus musculus 157-161 35500448-2 2022 This study aims to explore the molecular mechanism underlying antidepressant and analgetic effect of salvianolic acid B (SalB) in comorbid pain in depression induced by chronic restraint stress (CRS), which associates with GABAergic neuron activation in the amygdala and the ERK-CREB-BDNF signaling pathway. salvianolic acid B 101-119 mitogen-activated protein kinase 1 Mus musculus 275-278 35500448-2 2022 This study aims to explore the molecular mechanism underlying antidepressant and analgetic effect of salvianolic acid B (SalB) in comorbid pain in depression induced by chronic restraint stress (CRS), which associates with GABAergic neuron activation in the amygdala and the ERK-CREB-BDNF signaling pathway. salvianolic acid B 101-119 brain derived neurotrophic factor Mus musculus 284-288 35500448-9 2022 After intraperitoneal injection of SalB, the depression-like behaviors and pain threshold in CRS mice were alleviated, the effects of which could be eliminated by ERK-CREB-BDNF signaling pathway antagonist. salvianolic acid B 35-39 mitogen-activated protein kinase 1 Mus musculus 163-166 35500448-9 2022 After intraperitoneal injection of SalB, the depression-like behaviors and pain threshold in CRS mice were alleviated, the effects of which could be eliminated by ERK-CREB-BDNF signaling pathway antagonist. salvianolic acid B 35-39 cAMP responsive element binding protein 1 Mus musculus 167-171 35500448-9 2022 After intraperitoneal injection of SalB, the depression-like behaviors and pain threshold in CRS mice were alleviated, the effects of which could be eliminated by ERK-CREB-BDNF signaling pathway antagonist. salvianolic acid B 35-39 brain derived neurotrophic factor Mus musculus 172-176 35402586-7 2022 Immunohistochemical analysis revealed that nano-SAB treatment effectively suppressed Ki-67, proliferative cell nuclear antigen (PCNA), and cyclin D1 expression in high-risk dysplastic lesions compared to free-SAB-treated and 4NQO-exposed groups (all P<0.05). salvianolic acid B 48-51 antigen identified by monoclonal antibody Ki 67 Mus musculus 85-90 35502178-0 2022 Salvianolic Acid B Suppresses Non-Small-Cell Lung Cancer Metastasis through PKM2-Independent Metabolic Reprogramming. salvianolic acid B 0-18 pyruvate kinase M1/2 Homo sapiens 76-80 35502178-10 2022 Additionally, Sal B downregulated the expression of PKM2, LDHA, and GLUT1. salvianolic acid B 14-19 pyruvate kinase M1/2 Homo sapiens 52-56 35502178-10 2022 Additionally, Sal B downregulated the expression of PKM2, LDHA, and GLUT1. salvianolic acid B 14-19 lactate dehydrogenase A Homo sapiens 58-62 35502178-10 2022 Additionally, Sal B downregulated the expression of PKM2, LDHA, and GLUT1. salvianolic acid B 14-19 solute carrier family 2 member 1 Homo sapiens 68-73 35502178-12 2022 Conclusion: Our findings provide evidence that Sal B enables to weaken NSCLC metastasis through PKM2-independent metabolic reprogramming, which sheds light on the promising therapeutic usage of Sal B in treating NSCLC. salvianolic acid B 47-52 pyruvate kinase M1/2 Homo sapiens 96-100 35502178-12 2022 Conclusion: Our findings provide evidence that Sal B enables to weaken NSCLC metastasis through PKM2-independent metabolic reprogramming, which sheds light on the promising therapeutic usage of Sal B in treating NSCLC. salvianolic acid B 194-199 pyruvate kinase M1/2 Homo sapiens 96-100 35348194-0 2022 Salvianolic acid B acts against non-small cell lung cancer A549 cells via inactivation of the MAPK and Smad2/3 signaling pathways. salvianolic acid B 0-18 SMAD family member 2 Homo sapiens 103-110 35348194-6 2022 The results demonstrated that Sal B inhibited TGF-beta1-induced EMT and migration of A549 cells, hampered cell cycle progression and induced cell autophagy and apoptosis. salvianolic acid B 30-35 transforming growth factor beta 1 Homo sapiens 46-55 35348194-9 2022 The results of the present study indicated that the underlying active mechanism of Sal B in NSCLC may be closely related to the impeded activation of the MAPK and Smad2/3 signaling pathways. salvianolic acid B 83-88 SMAD family member 2 Homo sapiens 163-170 35402586-7 2022 Immunohistochemical analysis revealed that nano-SAB treatment effectively suppressed Ki-67, proliferative cell nuclear antigen (PCNA), and cyclin D1 expression in high-risk dysplastic lesions compared to free-SAB-treated and 4NQO-exposed groups (all P<0.05). salvianolic acid B 48-51 proliferating cell nuclear antigen Mus musculus 92-126 35402586-7 2022 Immunohistochemical analysis revealed that nano-SAB treatment effectively suppressed Ki-67, proliferative cell nuclear antigen (PCNA), and cyclin D1 expression in high-risk dysplastic lesions compared to free-SAB-treated and 4NQO-exposed groups (all P<0.05). salvianolic acid B 48-51 proliferating cell nuclear antigen Mus musculus 128-132 35402586-7 2022 Immunohistochemical analysis revealed that nano-SAB treatment effectively suppressed Ki-67, proliferative cell nuclear antigen (PCNA), and cyclin D1 expression in high-risk dysplastic lesions compared to free-SAB-treated and 4NQO-exposed groups (all P<0.05). salvianolic acid B 48-51 cyclin D1 Mus musculus 139-148 35251486-0 2022 Corrigendum to "Salvianolic Acid B Protects Intervertebral Discs from Oxidative Stress-Induced Degeneration via Activation of the JAK2/STAT3 Signaling Pathway". salvianolic acid B 16-34 Janus kinase 2 Homo sapiens 130-134 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 poly (ADP-ribose) polymerase 1 Rattus norvegicus 60-64 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 caspase 9 Rattus norvegicus 93-102 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 BCL2 associated X, apoptosis regulator Rattus norvegicus 104-107 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 NLR family, pyrin domain containing 3 Rattus norvegicus 109-114 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 PYD and CARD domain containing Rattus norvegicus 116-119 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 interleukin 1 alpha Rattus norvegicus 125-134 35084700-8 2022 Furthermore, treatment with Sal B down-regulated HG-induced PARP, cleaved-caspase 3, cleaved-caspase 9, Bax, NLRP3, ASC, and IL-1 beta expression, but mitigated HG-mediated down-regulation of Bcl-2 expression (P<0.05). salvianolic acid B 28-33 BCL2, apoptosis regulator Rattus norvegicus 192-197 35251486-0 2022 Corrigendum to "Salvianolic Acid B Protects Intervertebral Discs from Oxidative Stress-Induced Degeneration via Activation of the JAK2/STAT3 Signaling Pathway". salvianolic acid B 16-34 signal transducer and activator of transcription 3 Homo sapiens 135-140 35039992-7 2022 Docking results showed salvianolic acid B and ellagic acid in phenols, and oridonin and triptolide in terpenoids had a better binding activity with NLRP3, which can provide theoretical support for finding novel NLRP3 inflammasome inhibitors or lead compounds in the future. salvianolic acid B 23-41 NLR family pyrin domain containing 3 Homo sapiens 148-153 35039992-7 2022 Docking results showed salvianolic acid B and ellagic acid in phenols, and oridonin and triptolide in terpenoids had a better binding activity with NLRP3, which can provide theoretical support for finding novel NLRP3 inflammasome inhibitors or lead compounds in the future. salvianolic acid B 23-41 NLR family pyrin domain containing 3 Homo sapiens 211-216 33975276-3 2021 Here, a novel, superior, self-healing elastin-mimic peptide hydrogel (EMH) was fabricated for the local delivery of salvianolic acid B (SaB). salvianolic acid B 116-134 elastin Homo sapiens 38-45 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 albumin Rattus norvegicus 86-89 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 plasminogen Rattus norvegicus 91-94 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 angiotensin I converting enzyme Rattus norvegicus 96-99 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 caspase 3 Rattus norvegicus 101-106 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 matrix metallopeptidase 9 Rattus norvegicus 108-112 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 matrix metallopeptidase 2 Rattus norvegicus 114-118 34636119-9 2022 The pharmacology network results showed that Sal B and its metabolites could regulate ALB, PLG, ACE, CASP3, MMP9, MMP2, MTOR, etc. salvianolic acid B 45-50 mechanistic target of rapamycin kinase Rattus norvegicus 120-124 33899116-0 2021 Salvianolic acid B inhibits myofibroblast differentiation and extracellular matrix accumulation in nasal polyp fibroblasts via the TGF-beta1 signaling pathway. salvianolic acid B 0-18 transforming growth factor beta 1 Homo sapiens 131-140 33899116-10 2021 The results indicated that Sal B significantly downregulated TGF-beta1-induced alpha-SMA, fibronectin and collagen III expression levels in NPFs. salvianolic acid B 27-32 transforming growth factor beta 1 Homo sapiens 61-70 33899116-10 2021 The results indicated that Sal B significantly downregulated TGF-beta1-induced alpha-SMA, fibronectin and collagen III expression levels in NPFs. salvianolic acid B 27-32 actin alpha 1, skeletal muscle Homo sapiens 79-88 33899116-10 2021 The results indicated that Sal B significantly downregulated TGF-beta1-induced alpha-SMA, fibronectin and collagen III expression levels in NPFs. salvianolic acid B 27-32 fibronectin 1 Homo sapiens 90-101 33899116-11 2021 Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. salvianolic acid B 11-16 transforming growth factor beta 1 Homo sapiens 41-50 33899116-11 2021 Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. salvianolic acid B 11-16 transforming growth factor beta receptor 1 Homo sapiens 59-67 33899116-11 2021 Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. salvianolic acid B 11-16 transforming growth factor beta receptor 2 Homo sapiens 69-78 33899116-11 2021 Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. salvianolic acid B 11-16 SMAD family member 2 Homo sapiens 82-89 33899116-11 2021 Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. salvianolic acid B 11-16 matrix metallopeptidase 2 Homo sapiens 91-96 33899116-11 2021 Similarly, Sal B significantly decreased TGF-beta1-induced TbetaR-I, TbetaR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. salvianolic acid B 11-16 matrix metallopeptidase 9 Homo sapiens 101-106 33899116-12 2021 Furthermore, Sal B significantly decreased TGF-beta1-induced NPF migration. salvianolic acid B 13-18 transforming growth factor beta 1 Homo sapiens 43-52 33580518-3 2021 In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2h cells). salvianolic acid B 104-107 angiotensin converting enzyme 2 Homo sapiens 120-124 33580518-3 2021 In this study, we used Cell Counting Kit-8 staining and flow cytometry to evaluate the toxicity of SAA, SAB, and SAC on ACE2 (angiotensin-converting enzyme 2) high-expressing HEK293T cells (ACE2h cells). salvianolic acid B 104-107 angiotensin converting enzyme 2 Homo sapiens 126-157 35068334-8 2022 Our results showed that Sal B significantly ameliorated hyperlipidemia, hyperglycemia, hyperinsulinemia, and insulin resistance in db/db mice. salvianolic acid B 24-29 insulin Homo sapiens 109-116 35068334-10 2022 In diabetic thoracic aorta, HG- and CCCP-induced HUVECs, Sal B distinctly increased Bcl-2 expression and reduced BAX, Beclin1, Parkin and Pink1 expression, thereby protecting endothelial cells from apoptosis and mitophagy. salvianolic acid B 57-62 BCL2 apoptosis regulator Homo sapiens 84-89 35068334-10 2022 In diabetic thoracic aorta, HG- and CCCP-induced HUVECs, Sal B distinctly increased Bcl-2 expression and reduced BAX, Beclin1, Parkin and Pink1 expression, thereby protecting endothelial cells from apoptosis and mitophagy. salvianolic acid B 57-62 BCL2 associated X, apoptosis regulator Homo sapiens 113-116 35068334-10 2022 In diabetic thoracic aorta, HG- and CCCP-induced HUVECs, Sal B distinctly increased Bcl-2 expression and reduced BAX, Beclin1, Parkin and Pink1 expression, thereby protecting endothelial cells from apoptosis and mitophagy. salvianolic acid B 57-62 beclin 1 Homo sapiens 118-125 35068334-10 2022 In diabetic thoracic aorta, HG- and CCCP-induced HUVECs, Sal B distinctly increased Bcl-2 expression and reduced BAX, Beclin1, Parkin and Pink1 expression, thereby protecting endothelial cells from apoptosis and mitophagy. salvianolic acid B 57-62 PTEN induced kinase 1 Homo sapiens 138-143 35068334-12 2022 Collectively, Sal B exhibited a potential to improve diabetes-induced endothelial and mitochondrial dysfunction through down-regulating apoptosis and mitophagy of endothelial cells.Abbreviations: DM: diabetes mellitus; T2DM: type 2 diabetes mellitus; Sal B: Salvianolic acid B; HG: high glucose; FBG: fasting blood glucose; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; FINS: fasting insulin; HOMA-IR: homeostasis model assessment insulin resistance; QUICKI: quantitative insulin-sensitivity check index; H&E: hematoxylin and eosin; HUVECs: human umbilical vein endothelial cells; IHC: immunohistochemistry; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; FCM: flow cytometry; CCK-8: cell counting kit-8. salvianolic acid B 14-19 insulin Homo sapiens 469-476 35068334-12 2022 Collectively, Sal B exhibited a potential to improve diabetes-induced endothelial and mitochondrial dysfunction through down-regulating apoptosis and mitophagy of endothelial cells.Abbreviations: DM: diabetes mellitus; T2DM: type 2 diabetes mellitus; Sal B: Salvianolic acid B; HG: high glucose; FBG: fasting blood glucose; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; FINS: fasting insulin; HOMA-IR: homeostasis model assessment insulin resistance; QUICKI: quantitative insulin-sensitivity check index; H&E: hematoxylin and eosin; HUVECs: human umbilical vein endothelial cells; IHC: immunohistochemistry; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; FCM: flow cytometry; CCK-8: cell counting kit-8. salvianolic acid B 14-19 insulin Homo sapiens 516-523 35068334-12 2022 Collectively, Sal B exhibited a potential to improve diabetes-induced endothelial and mitochondrial dysfunction through down-regulating apoptosis and mitophagy of endothelial cells.Abbreviations: DM: diabetes mellitus; T2DM: type 2 diabetes mellitus; Sal B: Salvianolic acid B; HG: high glucose; FBG: fasting blood glucose; TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; FINS: fasting insulin; HOMA-IR: homeostasis model assessment insulin resistance; QUICKI: quantitative insulin-sensitivity check index; H&E: hematoxylin and eosin; HUVECs: human umbilical vein endothelial cells; IHC: immunohistochemistry; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; FCM: flow cytometry; CCK-8: cell counting kit-8. salvianolic acid B 14-19 insulin Homo sapiens 557-564 34033901-15 2021 The additional molecular dynamic simulations provided further insight into the entry inhibitory characteristics of salvianolic acid B against the HIV-1 gp120, with a stable pose being found within the CD4 binding site. salvianolic acid B 115-133 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 152-157 34033901-15 2021 The additional molecular dynamic simulations provided further insight into the entry inhibitory characteristics of salvianolic acid B against the HIV-1 gp120, with a stable pose being found within the CD4 binding site. salvianolic acid B 115-133 CD4 molecule Homo sapiens 201-204 33975276-3 2021 Here, a novel, superior, self-healing elastin-mimic peptide hydrogel (EMH) was fabricated for the local delivery of salvianolic acid B (SaB). salvianolic acid B 136-139 elastin Homo sapiens 38-45 33963705-0 2021 [Salvianolic acid B and its magnesium salt inhibit SARS-CoV-2 infection of Vero-E6 cells by blocking spike protein-mediated membrane fusion]. salvianolic acid B 1-19 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 101-106 33963705-5 2021 Flow cytometry was carried out to analyze the effect of Sal-B on the binding of SARS-CoV-2 RBD to hACE2 receptor. salvianolic acid B 56-61 angiotensin converting enzyme 2 Homo sapiens 98-103 33963705-7 2021 Both Sal-B and ZDDY successfully inhibited the entry of SARS-CoV-2 pseudovirus into the cells that stably expressed human ACE2 (ACE2/293T), with half maximal inhibitory concentrations (IC50) of 1.69 mumol/L and 24.81 mug/mL, respectively. salvianolic acid B 5-10 angiotensin converting enzyme 2 Homo sapiens 122-126 33963705-7 2021 Both Sal-B and ZDDY successfully inhibited the entry of SARS-CoV-2 pseudovirus into the cells that stably expressed human ACE2 (ACE2/293T), with half maximal inhibitory concentrations (IC50) of 1.69 mumol/L and 24.81 mug/mL, respectively. salvianolic acid B 5-10 angiotensin converting enzyme 2 Homo sapiens 128-137 33963705-13 2021 OBJECTIVE: Sal-B and its magnesium salt ZDDY can inhibit the entry of SARS-CoV-2 in Vero-E6 cells in vitro by blocking SARS-CoV-2 spike protein-mediated virus-cell membrane fusion. salvianolic acid B 11-16 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 130-135 33732314-1 2021 Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor beta/Smad signaling pathway. salvianolic acid B 0-18 tumor necrosis factor Homo sapiens 102-133 33847919-5 2021 Both lithospermic acid and salvianolic acid B markedly down-regulated the expression of factor Xa and factor IIa on the external surface of EA.hy926 cells and demonstrated significant anti-factor IIa and anti-factor Xa activity using chromogenic substrates in vitro. salvianolic acid B 27-45 coagulation factor X Homo sapiens 88-97 33847919-5 2021 Both lithospermic acid and salvianolic acid B markedly down-regulated the expression of factor Xa and factor IIa on the external surface of EA.hy926 cells and demonstrated significant anti-factor IIa and anti-factor Xa activity using chromogenic substrates in vitro. salvianolic acid B 27-45 coagulation factor X Homo sapiens 209-218 33847919-6 2021 Western blot results revealed that both lithospermic acid and salvianolic acid B also significantly inhibited the expression of TF, p-p65, p-p38, and pJNK proteins induced by TNF-alpha. salvianolic acid B 62-80 tumor necrosis factor Homo sapiens 175-184 33732314-1 2021 Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor beta/Smad signaling pathway. salvianolic acid B 20-25 tumor necrosis factor Homo sapiens 102-133 33732314-3 2021 The aims of the present study were to investigate the underlying mechanisms of Sal B on acute and chronic liver injury induced by CCl4 and H2O2, and its effects on p-Smad2C/L. salvianolic acid B 79-84 C-C motif chemokine ligand 4 Homo sapiens 130-134 33732314-3 2021 The aims of the present study were to investigate the underlying mechanisms of Sal B on acute and chronic liver injury induced by CCl4 and H2O2, and its effects on p-Smad2C/L. salvianolic acid B 79-84 SMAD family member 2 Homo sapiens 166-171 33505113-0 2021 Salvianolic acid B suppresses EMT and apoptosis to lessen drug resistance through AKT/mTOR in gastric cancer cells. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Homo sapiens 82-85 33548866-18 2021 When miR-19a or SIRT1 was inhibited, Sal B (0.5 mug/ml) can not decrease autophagy-related protein effectively. salvianolic acid B 37-42 microRNA 19a Homo sapiens 5-12 33548866-18 2021 When miR-19a or SIRT1 was inhibited, Sal B (0.5 mug/ml) can not decrease autophagy-related protein effectively. salvianolic acid B 37-42 sirtuin 1 Homo sapiens 16-21 33548866-20 2021 And Sal B (0.5 mug/ml) inhibited HUVECs autophagy via miR-19a/SIRT1 pathway. salvianolic acid B 4-9 microRNA 19a Homo sapiens 54-61 33548866-20 2021 And Sal B (0.5 mug/ml) inhibited HUVECs autophagy via miR-19a/SIRT1 pathway. salvianolic acid B 4-9 sirtuin 1 Homo sapiens 62-67 33604164-4 2021 Mice in Rb1, SalB and Rb1SalB group were treated by gavage with ginsenoside Rb1, salvianolic acid B and the combination of the two ingredients, respectively. salvianolic acid B 81-99 RB transcriptional corepressor 1 Mus musculus 22-25 33604164-4 2021 Mice in Rb1, SalB and Rb1SalB group were treated by gavage with ginsenoside Rb1, salvianolic acid B and the combination of the two ingredients, respectively. salvianolic acid B 81-99 RB transcriptional corepressor 1 Mus musculus 22-25 33505113-0 2021 Salvianolic acid B suppresses EMT and apoptosis to lessen drug resistance through AKT/mTOR in gastric cancer cells. salvianolic acid B 0-18 mechanistic target of rapamycin kinase Homo sapiens 86-90 33952797-0 2021 Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway. salvianolic acid B 0-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 99-103 33438557-6 2021 RESULTS: Experimental in vitro testing of highest-ranked hits identified asperphenamate and salvianolic acid B as active SIRT2 inhibitors with IC50 values in low micromolar range. salvianolic acid B 92-110 sirtuin 2 Homo sapiens 121-126 32980439-0 2021 Salvianolic acid B blocks hepatic stellate cell activation via FGF19/FGFR4 signaling. salvianolic acid B 0-18 fibroblast growth factor 19 Homo sapiens 63-68 32980439-9 2021 RESULTS: Using the human HSC cell line LX-2, we screened several natural products and found that bioactive compounds isolated from Salvia miltiorrhiza, particularly salvianolic acid B, strongly upregulated FGF19 secretion by LX-2 cells. salvianolic acid B 165-183 fucosyltransferase 1 (H blood group) Homo sapiens 25-28 32980439-9 2021 RESULTS: Using the human HSC cell line LX-2, we screened several natural products and found that bioactive compounds isolated from Salvia miltiorrhiza, particularly salvianolic acid B, strongly upregulated FGF19 secretion by LX-2 cells. salvianolic acid B 165-183 fibroblast growth factor 19 Homo sapiens 206-211 32980439-10 2021 We further showed that salvianolic acid B inhibited lipopolysaccharide (LPS)-induced HSC proliferation and activation. salvianolic acid B 23-41 fucosyltransferase 1 (H blood group) Homo sapiens 85-88 32980439-12 2021 Salvianolic acid B treatment restored the impaired expressions of FGF19 and FGFR4. salvianolic acid B 0-18 fibroblast growth factor 19 Homo sapiens 66-71 32980439-13 2021 Finally, FGFR4 knockdown abolished the antifibrotic effects of salvianolic acid B in the LPS-induced HSC activation model. salvianolic acid B 63-81 fucosyltransferase 1 (H blood group) Homo sapiens 101-104 32980439-14 2021 CONCLUSIONS: Salvianolic acid B prevented LPS-induced HSC proliferation and activation by enhancing antifibrotic FGF19/FGFR4 signaling. salvianolic acid B 13-31 fucosyltransferase 1 (H blood group) Homo sapiens 54-57 32980439-14 2021 CONCLUSIONS: Salvianolic acid B prevented LPS-induced HSC proliferation and activation by enhancing antifibrotic FGF19/FGFR4 signaling. salvianolic acid B 13-31 fibroblast growth factor 19 Homo sapiens 113-118 33290806-0 2021 Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesis. salvianolic acid B 89-107 SMAD family member 3 Mus musculus 0-5 33290806-8 2021 Notably, in vivo functional studies revealed that pSmad3C mutation attenuates Sal B-induced ameliorative effects on histopathological characteristics and decreased serological biomarkers, and potential mechanism involves attenuation of increases in pSmad3C/p21 and decreases in pSmad3L/PAI-1/c-Myc expression. salvianolic acid B 78-83 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 257-260 33290806-8 2021 Notably, in vivo functional studies revealed that pSmad3C mutation attenuates Sal B-induced ameliorative effects on histopathological characteristics and decreased serological biomarkers, and potential mechanism involves attenuation of increases in pSmad3C/p21 and decreases in pSmad3L/PAI-1/c-Myc expression. salvianolic acid B 78-83 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 286-291 33365064-10 2021 Treatment with Salvia miltiorrhiza solution, salvianic acid A and salvianolic acid B significantly reduced the overexpression of cleaved caspase-3, cleaved caspase-9 and TNF-alpha compared with the H2O2-treated group (P<0.05). salvianolic acid B 66-84 caspase 3 Homo sapiens 137-146 33365064-10 2021 Treatment with Salvia miltiorrhiza solution, salvianic acid A and salvianolic acid B significantly reduced the overexpression of cleaved caspase-3, cleaved caspase-9 and TNF-alpha compared with the H2O2-treated group (P<0.05). salvianolic acid B 66-84 caspase 9 Homo sapiens 156-165 33365064-10 2021 Treatment with Salvia miltiorrhiza solution, salvianic acid A and salvianolic acid B significantly reduced the overexpression of cleaved caspase-3, cleaved caspase-9 and TNF-alpha compared with the H2O2-treated group (P<0.05). salvianolic acid B 66-84 tumor necrosis factor Homo sapiens 170-179 33064567-8 2020 Treatment with SalB for 7 days in CHF rats decreased MMP9 activity and cardiac fibrosis but increased autophagic flux in the peri-infarct myocardium. salvianolic acid B 15-19 matrix metallopeptidase 9 Rattus norvegicus 53-57 33174042-8 2020 In vitro, the results of reactive oxygen species (ROS) detection, JC-1 staining, western blotting and TUNEL assays showed that Sal B treatment significantly inhibited intracellular ROS production, increased the mitochondrial membrane potential, regulated the expression of mitophagy-related proteins, inhibited the activation of the NLRP3 inflammasome and inhibited apoptosis in H9C2 cells. salvianolic acid B 127-132 NLR family, pyrin domain containing 3 Rattus norvegicus 333-338 32955050-0 2020 Salvianolic acid B prevents body weight gain and regulates gut microbiota and LPS/TLR4 signaling pathway in high-fat diet-induced obese mice. salvianolic acid B 0-18 toll-like receptor 4 Mus musculus 82-86 33174042-0 2020 Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome. salvianolic acid B 0-18 NLR family, pyrin domain containing 3 Rattus norvegicus 113-118 32955050-8 2020 In addition, Sal B downregulates the expressions of TLR4 and myeloid differential factor-88, as well as the phosphorylation levels of Jun N-terminal kinase, nuclear factor-kappa B p65, and an insulin receptor substrate in the WAT. salvianolic acid B 13-18 toll-like receptor 4 Mus musculus 52-56 32955050-9 2020 In summary, Sal B may attenuate body weight gain and insulin resistance through the regulation of gut microbiota abundances and LPS/TLR4 signaling pathway in obese mice, suggesting Sal B could be a promising drug candidate for protection against obesity. salvianolic acid B 12-17 toll-like receptor 4 Mus musculus 132-136 32955050-9 2020 In summary, Sal B may attenuate body weight gain and insulin resistance through the regulation of gut microbiota abundances and LPS/TLR4 signaling pathway in obese mice, suggesting Sal B could be a promising drug candidate for protection against obesity. salvianolic acid B 181-186 toll-like receptor 4 Mus musculus 132-136 32739616-0 2020 Salvianolic acid B ameliorates atherosclerosis via inhibiting YAP/TAZ/JNK signaling pathway in endothelial cells and pericytes. salvianolic acid B 0-18 yes-associated protein 1 Mus musculus 62-65 32739616-0 2020 Salvianolic acid B ameliorates atherosclerosis via inhibiting YAP/TAZ/JNK signaling pathway in endothelial cells and pericytes. salvianolic acid B 0-18 mitogen-activated protein kinase 8 Mus musculus 70-73 33013384-0 2020 Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway. salvianolic acid B 17-35 caspase 1 Mus musculus 46-55 32645333-5 2020 Both SAB and STS significantly inhibited LPS-induced inflammation in vitro, including down-regulated the protein expression levels of IL-1beta and TNF-alpha and the mRNA expression levels of IL1B and TNFA. salvianolic acid B 5-8 interleukin 1 alpha Homo sapiens 134-142 32645333-5 2020 Both SAB and STS significantly inhibited LPS-induced inflammation in vitro, including down-regulated the protein expression levels of IL-1beta and TNF-alpha and the mRNA expression levels of IL1B and TNFA. salvianolic acid B 5-8 tumor necrosis factor Homo sapiens 147-156 32645333-5 2020 Both SAB and STS significantly inhibited LPS-induced inflammation in vitro, including down-regulated the protein expression levels of IL-1beta and TNF-alpha and the mRNA expression levels of IL1B and TNFA. salvianolic acid B 5-8 interleukin 1 beta Homo sapiens 191-195 32645333-5 2020 Both SAB and STS significantly inhibited LPS-induced inflammation in vitro, including down-regulated the protein expression levels of IL-1beta and TNF-alpha and the mRNA expression levels of IL1B and TNFA. salvianolic acid B 5-8 tumor necrosis factor Homo sapiens 200-204 33013384-0 2020 Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway. salvianolic acid B 17-35 nuclear factor, erythroid derived 2, like 2 Mus musculus 117-121 32765761-14 2020 In summary, these results indicate that SalB mitigates sepsis-induced liver injury via reduction of the inflammatory response and hepatic apoptosis, and the underlying mechanism may be associated with the activation of SIRT1/PGC-1alpha signaling. salvianolic acid B 40-44 sirtuin 1 Mus musculus 219-224 31023105-1 2020 PURPOSE: To investigate whether salvianolic acid B is able to enhance repair of degenerated intervertebral discs by mesenchymal stem cells (MSCs) through the promotion of MSC differentiation into nucleus pulposus cells in a nucleus-pulposus-like environment and by enhancing the trophic effect of MSCs on residual nucleus pulposus cells (mediated by transforming growth factor-beta1). salvianolic acid B 32-50 LOW QUALITY PROTEIN: transforming growth factor beta-1 Oryctolagus cuniculus 350-382 32765761-14 2020 In summary, these results indicate that SalB mitigates sepsis-induced liver injury via reduction of the inflammatory response and hepatic apoptosis, and the underlying mechanism may be associated with the activation of SIRT1/PGC-1alpha signaling. salvianolic acid B 40-44 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 225-235 32765761-0 2020 Salvianolic acid B protects against sepsis-induced liver injury via activation of SIRT1/PGC-1alpha signaling. salvianolic acid B 0-18 sirtuin 1 Mus musculus 82-87 32626974-6 2020 In vitro, Sal B downregulated the expression levels of HPSE/FGF-2/TGF-beta1/alpha-smooth muscle actin and upregulated the expression levels of SDC1/E-cadherin in angiotensin II-stimulated HK-2 cells in a dose-dependent manner. salvianolic acid B 10-15 heparanase Mus musculus 55-59 32765761-0 2020 Salvianolic acid B protects against sepsis-induced liver injury via activation of SIRT1/PGC-1alpha signaling. salvianolic acid B 0-18 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 88-98 32765761-11 2020 SalB also decreased the levels of the inflammatory cytokines TNF-alpha and IL-6 in the serum and the liver of the CLP model mice. salvianolic acid B 0-4 tumor necrosis factor Mus musculus 61-70 32765761-11 2020 SalB also decreased the levels of the inflammatory cytokines TNF-alpha and IL-6 in the serum and the liver of the CLP model mice. salvianolic acid B 0-4 interleukin 6 Mus musculus 75-79 32450523-0 2020 Salvianolic acid B attenuates epithelial-mesenchymal transition in renal fibrosis rats through activating Sirt1-mediated autophagy. salvianolic acid B 0-18 sirtuin 1 Rattus norvegicus 106-111 32450523-7 2020 In vitro, our study showed that SalB reversed EMT in TGF-beta1-induced human kidney proximal tubular epithelial cells (HK-2 cells). salvianolic acid B 32-36 transforming growth factor beta 1 Homo sapiens 53-62 32450523-8 2020 Further mechanism studies showed that the inhibition of Sirt1 and autophagy could reverse the protective effect of SalB on the EMT process in TGF-beta1-induced HK-2 cells. salvianolic acid B 115-119 sirtuin 1 Rattus norvegicus 56-61 32450523-8 2020 Further mechanism studies showed that the inhibition of Sirt1 and autophagy could reverse the protective effect of SalB on the EMT process in TGF-beta1-induced HK-2 cells. salvianolic acid B 115-119 transforming growth factor beta 1 Homo sapiens 142-151 32626974-0 2020 Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis. salvianolic acid B 0-18 heparanase Mus musculus 76-80 32626974-6 2020 In vitro, Sal B downregulated the expression levels of HPSE/FGF-2/TGF-beta1/alpha-smooth muscle actin and upregulated the expression levels of SDC1/E-cadherin in angiotensin II-stimulated HK-2 cells in a dose-dependent manner. salvianolic acid B 10-15 fibroblast growth factor 2 Mus musculus 60-65 32626974-6 2020 In vitro, Sal B downregulated the expression levels of HPSE/FGF-2/TGF-beta1/alpha-smooth muscle actin and upregulated the expression levels of SDC1/E-cadherin in angiotensin II-stimulated HK-2 cells in a dose-dependent manner. salvianolic acid B 10-15 transforming growth factor, beta 1 Mus musculus 66-75 32626974-0 2020 Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis. salvianolic acid B 0-18 syndecan 1 Mus musculus 81-85 32626974-3 2020 The present study demonstrated that Sal B could alleviate renal injury by regulating the heparanase/syndecan-1 (HPSE/SDC1) axis. salvianolic acid B 36-41 heparanase Mus musculus 112-116 32626974-6 2020 In vitro, Sal B downregulated the expression levels of HPSE/FGF-2/TGF-beta1/alpha-smooth muscle actin and upregulated the expression levels of SDC1/E-cadherin in angiotensin II-stimulated HK-2 cells in a dose-dependent manner. salvianolic acid B 10-15 syndecan 1 Mus musculus 143-147 32626974-3 2020 The present study demonstrated that Sal B could alleviate renal injury by regulating the heparanase/syndecan-1 (HPSE/SDC1) axis. salvianolic acid B 36-41 syndecan 1 Mus musculus 117-121 32626974-6 2020 In vitro, Sal B downregulated the expression levels of HPSE/FGF-2/TGF-beta1/alpha-smooth muscle actin and upregulated the expression levels of SDC1/E-cadherin in angiotensin II-stimulated HK-2 cells in a dose-dependent manner. salvianolic acid B 10-15 cadherin 1 Mus musculus 148-158 32626974-7 2020 In summary, to the best of the authors" knowledge, the present study provided evidence for the first time that Sal B could exert renal-protective effects via the inhibition of the HPSE/SDC1 axis, and these results suggest that the administration of Sal B may be a novel therapeutic strategy in treating renal interstitial fibrosis. salvianolic acid B 111-116 heparanase Mus musculus 180-184 32626974-7 2020 In summary, to the best of the authors" knowledge, the present study provided evidence for the first time that Sal B could exert renal-protective effects via the inhibition of the HPSE/SDC1 axis, and these results suggest that the administration of Sal B may be a novel therapeutic strategy in treating renal interstitial fibrosis. salvianolic acid B 111-116 syndecan 1 Mus musculus 185-189 32626974-7 2020 In summary, to the best of the authors" knowledge, the present study provided evidence for the first time that Sal B could exert renal-protective effects via the inhibition of the HPSE/SDC1 axis, and these results suggest that the administration of Sal B may be a novel therapeutic strategy in treating renal interstitial fibrosis. salvianolic acid B 249-254 heparanase Mus musculus 180-184 32626974-7 2020 In summary, to the best of the authors" knowledge, the present study provided evidence for the first time that Sal B could exert renal-protective effects via the inhibition of the HPSE/SDC1 axis, and these results suggest that the administration of Sal B may be a novel therapeutic strategy in treating renal interstitial fibrosis. salvianolic acid B 249-254 syndecan 1 Mus musculus 185-189 32494183-12 2020 SalB treatment also reversed CMS-induced inhibition of Nrf2 signaling pathway, along with increasing the mRNA expression of NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1). salvianolic acid B 0-4 NFE2 like bZIP transcription factor 2 Rattus norvegicus 55-59 31853618-8 2020 Overall, the present study indicated that Sal B attenuated myocardial I/R injury by activating PI3K/Akt and inhibiting the release of HMGB1 in rats. salvianolic acid B 42-47 high mobility group box 1 Rattus norvegicus 134-139 32571632-2 2020 Our previous research found Disabled-2 (DAB2) expression was significantly downregulated by salvianolic acid B, a small molecular medicine which attenuated experimental skin fibrosis of SSc. salvianolic acid B 92-110 disabled 2, mitogen-responsive phosphoprotein Mus musculus 28-38 32571632-2 2020 Our previous research found Disabled-2 (DAB2) expression was significantly downregulated by salvianolic acid B, a small molecular medicine which attenuated experimental skin fibrosis of SSc. salvianolic acid B 92-110 disabled 2, mitogen-responsive phosphoprotein Mus musculus 40-44 32714485-0 2020 Salvianolic Acid B Improves Postresuscitation Myocardial and Cerebral Outcomes in a Murine Model of Cardiac Arrest: Involvement of Nrf2 Signaling Pathway. salvianolic acid B 0-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 32714485-10 2020 Mechanistically, Sal B dramatically promoted Nrf2 nuclear translocation through the downregulation of Keap1, which resulted in the expression of antioxidant enzymes, including HO-1 and NQO1, thereby counteracted the oxidative damage in response to CA/CPR. salvianolic acid B 17-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 45-49 32714485-10 2020 Mechanistically, Sal B dramatically promoted Nrf2 nuclear translocation through the downregulation of Keap1, which resulted in the expression of antioxidant enzymes, including HO-1 and NQO1, thereby counteracted the oxidative damage in response to CA/CPR. salvianolic acid B 17-22 kelch-like ECH-associated protein 1 Mus musculus 102-107 32714485-10 2020 Mechanistically, Sal B dramatically promoted Nrf2 nuclear translocation through the downregulation of Keap1, which resulted in the expression of antioxidant enzymes, including HO-1 and NQO1, thereby counteracted the oxidative damage in response to CA/CPR. salvianolic acid B 17-22 heme oxygenase 1 Mus musculus 176-180 32714485-10 2020 Mechanistically, Sal B dramatically promoted Nrf2 nuclear translocation through the downregulation of Keap1, which resulted in the expression of antioxidant enzymes, including HO-1 and NQO1, thereby counteracted the oxidative damage in response to CA/CPR. salvianolic acid B 17-22 NAD(P)H dehydrogenase, quinone 1 Mus musculus 185-189 32714485-11 2020 The aforementioned antiapoptotic and antioxidant effects of Sal B were impaired in the setting of gene silencing of Nrf2 with siRNA in vitro model. salvianolic acid B 60-65 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 32714485-13 2020 Our findings suggest that the administration of Sal B improved cardiac function and neurological outcomes in a murine model of CA via activating the Nrf2 antioxidant signaling pathway, which may represent a novel therapeutic strategy for the treatment of CA. salvianolic acid B 48-53 nuclear factor, erythroid derived 2, like 2 Mus musculus 149-153 32472783-0 2020 Salvianolic acid B decreases interleukin-1beta-induced colitis recurrence in mice. salvianolic acid B 0-18 interleukin 1 beta Mus musculus 29-46 32472783-8 2020 High MLCK expression in colitis group was reversed by Sal B (182.44 +- 89.42% vs. 296.23 +- 30.78%, P = 0.0028) but not SASP (285.23 +- 41.04% vs. 296.23 +- 30.78%, P > 0.05). salvianolic acid B 54-59 myosin light chain kinase 3 Mus musculus 5-9 32472783-9 2020 The recurrence rate induced by recombinant human IL-1beta in Sal B-treated group was significantly lower than that in SASP-treated group. salvianolic acid B 61-66 interleukin 1 alpha Homo sapiens 49-57 32627473-0 2020 [Salvianolic acid B regulates mitochondrial autophagy mediated by NIX to protect H9c2 cardiomyocytes from hypoxia/reoxygenation injury]. salvianolic acid B 1-19 BCL2 interacting protein 3 like Homo sapiens 66-69 32627473-1 2020 The aim of this paper was to investigate whether the mechanism of salvianolic acid B in protecting H9 c2 cardiomyocytes from hypoxia/reoxygenation injury is related to the regulation of mitochondrial autophagy mediated by NIX. salvianolic acid B 66-84 BCL2 interacting protein 3 like Homo sapiens 222-225 32429542-7 2020 The results showed that salvianolic acid B-containing microemulsion alleviated disease severity, reduced acanthosis, and inhibited interleukin-23/interleukin-17 (IL-23/IL-17) cytokines, epidermal proliferation, and increased skin hydration. salvianolic acid B 24-42 interleukin 23, alpha subunit p19 Mus musculus 162-167 32429542-7 2020 The results showed that salvianolic acid B-containing microemulsion alleviated disease severity, reduced acanthosis, and inhibited interleukin-23/interleukin-17 (IL-23/IL-17) cytokines, epidermal proliferation, and increased skin hydration. salvianolic acid B 24-42 interleukin 17A Mus musculus 168-173 31853618-0 2020 Salvianolic acid B protects against myocardial ischaemia-reperfusion injury in rats via inhibiting high mobility group box 1 protein expression through the PI3K/Akt signalling pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 161-164 31853618-6 2020 In the current study, Sal B significantly ameliorated myocardial I/R injury in a dose-dependent manner, ameliorated cardiac function, reduced myocardial infarction size, decreased myocardial injury marker expression, decreased inflammatory responses, reduced apoptosis, activated PI3K/Akt expression and inhibited HMGB1 expression. salvianolic acid B 22-27 AKT serine/threonine kinase 1 Rattus norvegicus 285-288 31853618-6 2020 In the current study, Sal B significantly ameliorated myocardial I/R injury in a dose-dependent manner, ameliorated cardiac function, reduced myocardial infarction size, decreased myocardial injury marker expression, decreased inflammatory responses, reduced apoptosis, activated PI3K/Akt expression and inhibited HMGB1 expression. salvianolic acid B 22-27 high mobility group box 1 Rattus norvegicus 314-319 31853618-8 2020 Overall, the present study indicated that Sal B attenuated myocardial I/R injury by activating PI3K/Akt and inhibiting the release of HMGB1 in rats. salvianolic acid B 42-47 AKT serine/threonine kinase 1 Rattus norvegicus 100-103 32516126-0 2020 Salvianolic Acid B improves cognitive impairment by inhibiting neuroinflammation and decreasing Abeta level in Porphyromonas gingivalis-infected mice. salvianolic acid B 0-18 amyloid beta (A4) precursor protein Mus musculus 96-101 32494183-0 2020 Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway. salvianolic acid B 0-18 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 101-105 32494183-0 2020 Salvianolic Acid B Improves Chronic Mild Stress-Induced Depressive Behaviors in Rats: Involvement of AMPK/SIRT1 Signaling Pathway. salvianolic acid B 0-18 sirtuin 1 Rattus norvegicus 106-111 32494183-12 2020 SalB treatment also reversed CMS-induced inhibition of Nrf2 signaling pathway, along with increasing the mRNA expression of NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1). salvianolic acid B 0-4 crystallin zeta Rattus norvegicus 132-154 32494183-12 2020 SalB treatment also reversed CMS-induced inhibition of Nrf2 signaling pathway, along with increasing the mRNA expression of NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1). salvianolic acid B 0-4 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 156-161 32494183-12 2020 SalB treatment also reversed CMS-induced inhibition of Nrf2 signaling pathway, along with increasing the mRNA expression of NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1). salvianolic acid B 0-4 heme oxygenase 1 Rattus norvegicus 167-183 32494183-12 2020 SalB treatment also reversed CMS-induced inhibition of Nrf2 signaling pathway, along with increasing the mRNA expression of NAD(P)H:quinone oxidoreductase (NQO-1) and heme oxygenase 1 (HO-1). salvianolic acid B 0-4 heme oxygenase 1 Rattus norvegicus 185-189 32494183-13 2020 Regarding the endoplasmic reticulum (ER) stress markers, the protein expressions of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 kD (GRP78) were also significantly reduced after SalB administration. salvianolic acid B 198-202 DNA-damage inducible transcript 3 Rattus norvegicus 84-108 32494183-13 2020 Regarding the endoplasmic reticulum (ER) stress markers, the protein expressions of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 kD (GRP78) were also significantly reduced after SalB administration. salvianolic acid B 198-202 DNA-damage inducible transcript 3 Rattus norvegicus 110-114 32494183-13 2020 Regarding the endoplasmic reticulum (ER) stress markers, the protein expressions of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 kD (GRP78) were also significantly reduced after SalB administration. salvianolic acid B 198-202 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 120-151 32494183-13 2020 Regarding the endoplasmic reticulum (ER) stress markers, the protein expressions of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 kD (GRP78) were also significantly reduced after SalB administration. salvianolic acid B 198-202 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 153-158 32179247-0 2020 Salvianolic acid B promotes the osteogenic differentiation of human periodontal ligament cells through Wnt/beta-catenin signaling pathway. salvianolic acid B 0-18 catenin beta 1 Homo sapiens 107-119 32179247-11 2020 Sal B promoted the increase of ALP activity, osteogenic differentiation markers levels, mineralized nodules and activation of Wnt/beta-catenin signaling pathway, and DKK-1 could block those effects of Sal B on hPDLCs. salvianolic acid B 0-5 alkaline phosphatase, placental Homo sapiens 31-34 32179247-11 2020 Sal B promoted the increase of ALP activity, osteogenic differentiation markers levels, mineralized nodules and activation of Wnt/beta-catenin signaling pathway, and DKK-1 could block those effects of Sal B on hPDLCs. salvianolic acid B 0-5 catenin beta 1 Homo sapiens 130-142 32179247-11 2020 Sal B promoted the increase of ALP activity, osteogenic differentiation markers levels, mineralized nodules and activation of Wnt/beta-catenin signaling pathway, and DKK-1 could block those effects of Sal B on hPDLCs. salvianolic acid B 201-206 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 166-171 32179247-12 2020 CONCLUSION: Sal B promoted osteogenesis of hPDLCs through Wnt/beta-catenin signaling pathway, which providing a potential drug for periodontitis treatment. salvianolic acid B 12-17 catenin beta 1 Homo sapiens 62-74 32392912-0 2020 Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase/protein kinase B signaling pathway. salvianolic acid B 0-18 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 155-184 32392912-6 2020 Moreover, the protein expression of keratin markers (K16 and K17) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling proteins (pAkt/Akt and pPI3K/PI3K) were significantly downregulated after administration with SAB and MTX as compared with IMQ induced mice. salvianolic acid B 234-237 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 70-99 32395072-0 2020 Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering phosphatidylinositol-3-kinase/protein kinase B signaling pathway. salvianolic acid B 0-18 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 155-184 32395072-6 2020 Moreover, the protein expression of keratin markers (K16 and K17) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling proteins (pAkt/Akt and pPI3K/PI3K) were significantly downregulated after administration with SAB and MTX as compared with IMQ induced mice. salvianolic acid B 234-237 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 70-99 32392912-7 2020 Taking together, SAB and MTX significantly ameliorate psoriatic changes by inhibiting psoriatic inflammatory and keratin markers through abolishing PI3K/Akt signaling pathway. salvianolic acid B 17-20 thymoma viral proto-oncogene 1 Mus musculus 153-156 32395072-7 2020 Taking together, SAB and MTX significantly ameliorate psoriatic changes by inhibiting psoriatic inflammatory and keratin markers through abolishing PI3K/Akt signaling pathway. salvianolic acid B 17-20 thymoma viral proto-oncogene 1 Mus musculus 153-156 31930970-0 2020 Salvianolic acid B regulates macrophage polarization in ischemic/reperfused hearts by inhibiting mTORC1-induced glycolysis. salvianolic acid B 0-18 CREB regulated transcription coactivator 1 Mus musculus 97-103 31930970-3 2020 In primary cultured bone marrow-derived macrophages (BMDMs), SalB attenuated lipopolysaccharide (LPS)-induced M1 biomarkers (IL-6, iNOS, CCL2 and TNF-alpha) mRNA expression in a concentration-dependent manner. salvianolic acid B 61-65 interleukin 6 Homo sapiens 125-129 31930970-3 2020 In primary cultured bone marrow-derived macrophages (BMDMs), SalB attenuated lipopolysaccharide (LPS)-induced M1 biomarkers (IL-6, iNOS, CCL2 and TNF-alpha) mRNA expression in a concentration-dependent manner. salvianolic acid B 61-65 nitric oxide synthase 2 Homo sapiens 131-135 31930970-3 2020 In primary cultured bone marrow-derived macrophages (BMDMs), SalB attenuated lipopolysaccharide (LPS)-induced M1 biomarkers (IL-6, iNOS, CCL2 and TNF-alpha) mRNA expression in a concentration-dependent manner. salvianolic acid B 61-65 C-C motif chemokine ligand 2 Homo sapiens 137-141 31930970-3 2020 In primary cultured bone marrow-derived macrophages (BMDMs), SalB attenuated lipopolysaccharide (LPS)-induced M1 biomarkers (IL-6, iNOS, CCL2 and TNF-alpha) mRNA expression in a concentration-dependent manner. salvianolic acid B 61-65 tumor necrosis factor Homo sapiens 146-155 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 microRNA 26a Rattus norvegicus 218-225 31894515-8 2020 Icariin, salvianolic acid B, and plantainoside D are the most promising IKKbeta inhibitors. salvianolic acid B 9-27 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 72-79 31918160-7 2020 The populations of Nkp46 and cytotoxic CD8+ T cells in the placenta of female mice treated with SalB were significantly decreased. salvianolic acid B 96-100 natural cytotoxicity triggering receptor 1 Mus musculus 19-24 31790900-7 2020 RESULTS: Salvianolic acid B significantly decreased the expressions of TXB2 and ET-1 and increased the expression of 6-keto-PGF1alpha in plasma, and significantly inhibited the overexpression of TNF-alpha and iNOS in the femoral artery walls of TAO rats at medium and high doses. salvianolic acid B 9-27 tumor necrosis factor Rattus norvegicus 195-204 31790900-7 2020 RESULTS: Salvianolic acid B significantly decreased the expressions of TXB2 and ET-1 and increased the expression of 6-keto-PGF1alpha in plasma, and significantly inhibited the overexpression of TNF-alpha and iNOS in the femoral artery walls of TAO rats at medium and high doses. salvianolic acid B 9-27 nitric oxide synthase 2 Rattus norvegicus 209-213 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 29-34 transforming growth factor, beta 1 Mus musculus 46-55 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 SMAD family member 2 Mus musculus 201-206 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 transforming growth factor, beta 1 Mus musculus 260-269 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 305-310 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 actin alpha 2, smooth muscle, aorta Mus musculus 390-399 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 SMAD family member 2 Mus musculus 201-206 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 transforming growth factor, beta 1 Mus musculus 260-269 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 305-310 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 actin alpha 2, smooth muscle, aorta Mus musculus 390-399 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 SMAD family member 2 Mus musculus 201-206 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 transforming growth factor, beta 1 Mus musculus 260-269 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 305-310 31678285-5 2019 Results in vitro showed that Sal B restrained TGF-beta1-induced HSCs activation, Collagen I production and cell migration; Sal B inhibited activation of MAPK and markedly decreased protein levels of P-Smad2/3L and P-Smad2C while slightly increased P-Smad3C in TGF-beta1-stimulated HSCs, the expression of PAI-1 was inhibited by Sal B; activating MAPK receded inhibitory effects of Sal B on alpha-SMA, Collagen I, P-Smad2L and P-Smad3L expression while inhibited activation of MAPK reinforced those. salvianolic acid B 123-128 actin alpha 2, smooth muscle, aorta Mus musculus 390-399 31678285-6 2019 SIGNIFICANCE: Sal B attenuates liver fibrosis via mediation of TGF-beta/Smad and MAPK pathways, especially inhibition of MAPK-mediated P-Smad2/3L signaling, which maybe provides theoretical foundation of Sal B for treating clinically liver fibrosis. salvianolic acid B 14-19 transforming growth factor, beta 1 Mus musculus 63-71 31678285-6 2019 SIGNIFICANCE: Sal B attenuates liver fibrosis via mediation of TGF-beta/Smad and MAPK pathways, especially inhibition of MAPK-mediated P-Smad2/3L signaling, which maybe provides theoretical foundation of Sal B for treating clinically liver fibrosis. salvianolic acid B 14-19 SMAD family member 2 Mus musculus 137-142 31184214-6 2019 Sal-B was implicated in the enhancement of cell viability and suppression of apoptosis in OGD-treated H9c2 cells by repressing MEG3. salvianolic acid B 0-5 similar to GTL2, imprinted maternally expressed untranslated Rattus norvegicus 127-131 31184214-7 2019 In addition, MEG3 overexpression exerted an inhibitory effect on murine double minute 2 (MDM2) expression while aggrandized p53 expression in OGD-treated H9c2 cells which were pre-incubated with Sal-B. salvianolic acid B 195-200 maternally expressed 3 Mus musculus 13-17 32143619-4 2020 RESULTS: Salvianolic acid B and dihydromyricetin were the two compounds that strongly inhibited the fibril growth and neurotoxicity of alpha-syn. salvianolic acid B 9-27 synuclein alpha Homo sapiens 135-144 31604020-0 2020 Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2/HO-1 signaling pathway. salvianolic acid B 0-18 NFE2 like bZIP transcription factor 2 Homo sapiens 86-90 31604020-0 2020 Salvianolic acid B exerts a protective effect in acute liver injury by regulating the Nrf2/HO-1 signaling pathway. salvianolic acid B 0-18 heme oxygenase 1 Homo sapiens 91-95 31604020-3 2020 The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2/HO-1 signaling pathway. salvianolic acid B 75-80 NFE2 like bZIP transcription factor 2 Homo sapiens 146-150 31604020-3 2020 The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2/HO-1 signaling pathway. salvianolic acid B 75-80 heme oxygenase 1 Homo sapiens 151-155 32010242-0 2020 Salvianolic acid B activates Wnt/beta-catenin signaling following spinal cord injury. salvianolic acid B 0-18 Wnt family member 2 Rattus norvegicus 29-32 32010242-0 2020 Salvianolic acid B activates Wnt/beta-catenin signaling following spinal cord injury. salvianolic acid B 0-18 catenin beta 1 Rattus norvegicus 33-45 32010242-5 2020 Reverse transcription-quantitative PCR analysis demonstrated that Sal B treatment significantly enhanced the mRNA levels of lymphoid enhancer biding factor-1 and HNF1 homeobox A. salvianolic acid B 66-71 HNF1 homeobox A Rattus norvegicus 162-166 32010242-6 2020 In addition, Sal B treatment enhanced the expression of beta-catenin. salvianolic acid B 13-18 catenin beta 1 Rattus norvegicus 56-68 32010242-7 2020 Western blot analysis determined that Sal B treatment significantly decreased the expression of pro-apoptosis proteins, including Bax, cleaved caspase-3 and -9, in spinal cord tissues after SCI but enhanced the expression of Bcl-2, an anti-apoptotic protein. salvianolic acid B 38-43 BCL2 associated X, apoptosis regulator Rattus norvegicus 130-133 32010242-7 2020 Western blot analysis determined that Sal B treatment significantly decreased the expression of pro-apoptosis proteins, including Bax, cleaved caspase-3 and -9, in spinal cord tissues after SCI but enhanced the expression of Bcl-2, an anti-apoptotic protein. salvianolic acid B 38-43 BCL2, apoptosis regulator Rattus norvegicus 225-230 32010242-9 2020 In summary, the present study produced novel data demonstrating the neuroprotective effect of Sal B on SCI with the mechanism likely primarily mediated via the Wnt/beta-catenin signaling pathway. salvianolic acid B 94-99 Wnt family member 2 Rattus norvegicus 160-163 32010242-9 2020 In summary, the present study produced novel data demonstrating the neuroprotective effect of Sal B on SCI with the mechanism likely primarily mediated via the Wnt/beta-catenin signaling pathway. salvianolic acid B 94-99 catenin beta 1 Rattus norvegicus 164-176 31982427-0 2020 Salvianolic acid B improves myocardial function in diabetic cardiomyopathy by suppressing IGFBP3. salvianolic acid B 0-18 insulin-like growth factor binding protein 3 Mus musculus 90-96 31752055-0 2020 Salvianolic acid B inhibit Hand-foot-mouth disease enterovirus 71 replication through enhance AKT signaling pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Homo sapiens 94-97 31752055-10 2020 The Akt signaling pathway, a key component of cell survival and proliferation, was significantly increased in EV71-infected HeLa cells treated with 100 microg/mL SalB. salvianolic acid B 162-166 AKT serine/threonine kinase 1 Homo sapiens 4-7 31752055-12 2020 These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. salvianolic acid B 28-32 AKT serine/threonine kinase 1 Homo sapiens 43-46 31752055-12 2020 These results indicate that SalB activates Akt/PKB signaling and inhibits apoptosis in infected HeLa cells. salvianolic acid B 28-32 AKT serine/threonine kinase 1 Homo sapiens 47-50 31678285-0 2019 Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. salvianolic acid B 0-18 SMAD family member 2 Mus musculus 94-99 31678285-1 2019 AIM: To investigate anti-liver fibrosis effects of Salvianolic acid B (Sal B) from Salvia miltiorrhiza Bunge involved mitogen-activated protein kinase (MAPK)-mediated transforming growth factor-beta (TGF-beta) signaling. salvianolic acid B 51-69 transforming growth factor, beta 1 Mus musculus 200-208 31678285-1 2019 AIM: To investigate anti-liver fibrosis effects of Salvianolic acid B (Sal B) from Salvia miltiorrhiza Bunge involved mitogen-activated protein kinase (MAPK)-mediated transforming growth factor-beta (TGF-beta) signaling. salvianolic acid B 71-76 transforming growth factor, beta 1 Mus musculus 200-208 31678285-2 2019 MAIN METHODS: Diethylnitrosamine (DEN)-induced liver fibrosis in mice and TGF-beta1-activated hepatic stellate cells (HSCs) were established and treated with dosage/concentration-graded Sal B and/or MAPK activator (Vacquinol-1: MKK4-specific activator)/inhibitors (PD98059: ERK-specific inhibitor; SP600125: JNK-specific inhibitor; SB203580: p38-specific inhibitor). salvianolic acid B 186-191 transforming growth factor, beta 1 Mus musculus 74-83 31678285-4 2019 KEY FINDINGS: Results in vivo showed that Sal B alleviated DEN-caused liver fibrosis embodied in ameliorative histopathological characteristics and decreased protein levels of hepatic fibrosis related markers (alpha-SMA, Collagen I, TGF-beta1), its molecular mechanisms of action were correlative with inhibited activation of MAPK and phosphorylation of Smad2/3 at linker regions (P-Smad2/3L) and Smad2 at C-terminal (P-Smad2C) while increased phosphorylation of Smad3 at C-terminal (P-Smad3C). salvianolic acid B 42-47 actin alpha 2, smooth muscle, aorta Mus musculus 210-219 31678285-4 2019 KEY FINDINGS: Results in vivo showed that Sal B alleviated DEN-caused liver fibrosis embodied in ameliorative histopathological characteristics and decreased protein levels of hepatic fibrosis related markers (alpha-SMA, Collagen I, TGF-beta1), its molecular mechanisms of action were correlative with inhibited activation of MAPK and phosphorylation of Smad2/3 at linker regions (P-Smad2/3L) and Smad2 at C-terminal (P-Smad2C) while increased phosphorylation of Smad3 at C-terminal (P-Smad3C). salvianolic acid B 42-47 transforming growth factor, beta 1 Mus musculus 233-242 31678285-4 2019 KEY FINDINGS: Results in vivo showed that Sal B alleviated DEN-caused liver fibrosis embodied in ameliorative histopathological characteristics and decreased protein levels of hepatic fibrosis related markers (alpha-SMA, Collagen I, TGF-beta1), its molecular mechanisms of action were correlative with inhibited activation of MAPK and phosphorylation of Smad2/3 at linker regions (P-Smad2/3L) and Smad2 at C-terminal (P-Smad2C) while increased phosphorylation of Smad3 at C-terminal (P-Smad3C). salvianolic acid B 42-47 SMAD family member 2 Mus musculus 354-361 31678285-4 2019 KEY FINDINGS: Results in vivo showed that Sal B alleviated DEN-caused liver fibrosis embodied in ameliorative histopathological characteristics and decreased protein levels of hepatic fibrosis related markers (alpha-SMA, Collagen I, TGF-beta1), its molecular mechanisms of action were correlative with inhibited activation of MAPK and phosphorylation of Smad2/3 at linker regions (P-Smad2/3L) and Smad2 at C-terminal (P-Smad2C) while increased phosphorylation of Smad3 at C-terminal (P-Smad3C). salvianolic acid B 42-47 SMAD family member 2 Mus musculus 354-359 31678285-4 2019 KEY FINDINGS: Results in vivo showed that Sal B alleviated DEN-caused liver fibrosis embodied in ameliorative histopathological characteristics and decreased protein levels of hepatic fibrosis related markers (alpha-SMA, Collagen I, TGF-beta1), its molecular mechanisms of action were correlative with inhibited activation of MAPK and phosphorylation of Smad2/3 at linker regions (P-Smad2/3L) and Smad2 at C-terminal (P-Smad2C) while increased phosphorylation of Smad3 at C-terminal (P-Smad3C). salvianolic acid B 42-47 SMAD family member 2 Mus musculus 383-388 31678285-4 2019 KEY FINDINGS: Results in vivo showed that Sal B alleviated DEN-caused liver fibrosis embodied in ameliorative histopathological characteristics and decreased protein levels of hepatic fibrosis related markers (alpha-SMA, Collagen I, TGF-beta1), its molecular mechanisms of action were correlative with inhibited activation of MAPK and phosphorylation of Smad2/3 at linker regions (P-Smad2/3L) and Smad2 at C-terminal (P-Smad2C) while increased phosphorylation of Smad3 at C-terminal (P-Smad3C). salvianolic acid B 42-47 SMAD family member 3 Mus musculus 463-468 31603005-0 2019 Protective functions of salvianolic acid B in PC-12 cells against hydrogen peroxide-triggered damage by mediation of microRNA-26a. salvianolic acid B 24-42 microRNA 26a Rattus norvegicus 117-129 31603005-9 2019 Ascended miR-26a was monitored in Sal-B and H2O2-exposed cells. salvianolic acid B 34-39 microRNA 26a Rattus norvegicus 9-16 31603005-10 2019 MiR-26a inhibition annulled the protective action of Sal-B in H2O2-corrupted cells. salvianolic acid B 53-58 microRNA 26a Rattus norvegicus 0-7 31603005-11 2019 The protective function of Sal-B was enabled through activating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 27-32 AKT serine/threonine kinase 1 Rattus norvegicus 69-72 31603005-11 2019 The protective function of Sal-B was enabled through activating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 27-32 Eph receptor B1 Rattus norvegicus 81-84 31603005-12 2019 These findings delineated that Sal-B protected PC-12 cells against H2O2-caused injury through ascending miR-26a via initiating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 31-36 microRNA 26a Rattus norvegicus 104-111 31603005-12 2019 These findings delineated that Sal-B protected PC-12 cells against H2O2-caused injury through ascending miR-26a via initiating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 31-36 AKT serine/threonine kinase 1 Rattus norvegicus 132-135 31603005-12 2019 These findings delineated that Sal-B protected PC-12 cells against H2O2-caused injury through ascending miR-26a via initiating PI3K/AKT and MEK/ERK pathways. salvianolic acid B 31-36 Eph receptor B1 Rattus norvegicus 144-147 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 microRNA 26a Rattus norvegicus 153-160 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 Eph receptor B1 Rattus norvegicus 190-193 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 microRNA 26a Rattus norvegicus 218-225 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 microRNA 26a Rattus norvegicus 153-160 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 AKT serine/threonine kinase 1 Rattus norvegicus 178-181 31603005-13 2019 Highlights H2O2 causes PC-12 cell injury; Sal-B eases H2O2-caused PC-12 cell injury; Sal-B protects PC-12 cells against H2O2-caused injury via elevating miR-26a; Sal-B activates AKT and MEK/ERK pathways via modulating miR-26a. salvianolic acid B 85-90 Eph receptor B1 Rattus norvegicus 190-193 31726654-8 2019 Either Sal-B or cisplatin treatment decreased tumor tissue levels of tumor necrosis factor (TNF-alpha), matrix metalloproteinase-8 (MMP-8), and Cyclin D1 in ESC treated mice. salvianolic acid B 7-12 tumor necrosis factor Mus musculus 92-101 31449993-0 2019 The effect of TLR4/MyD88 inhibition by salvianolic acid B on neuropathic pain following spinal cord injury in mice. salvianolic acid B 39-57 toll-like receptor 4 Mus musculus 14-18 31449993-0 2019 The effect of TLR4/MyD88 inhibition by salvianolic acid B on neuropathic pain following spinal cord injury in mice. salvianolic acid B 39-57 myeloid differentiation primary response gene 88 Mus musculus 19-24 31184214-8 2019 Furthermore, MEG3 overexpression abolished the up-regulative effect of Sal-B on phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) in OGD-treated H9c2 cells. salvianolic acid B 71-76 similar to GTL2, imprinted maternally expressed untranslated Rattus norvegicus 13-17 31184214-8 2019 Furthermore, MEG3 overexpression abolished the up-regulative effect of Sal-B on phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) in OGD-treated H9c2 cells. salvianolic acid B 71-76 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 99-147 31184214-8 2019 Furthermore, MEG3 overexpression abolished the up-regulative effect of Sal-B on phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) in OGD-treated H9c2 cells. salvianolic acid B 71-76 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 149-153 31726654-8 2019 Either Sal-B or cisplatin treatment decreased tumor tissue levels of tumor necrosis factor (TNF-alpha), matrix metalloproteinase-8 (MMP-8), and Cyclin D1 in ESC treated mice. salvianolic acid B 7-12 tumor necrosis factor Mus musculus 69-90 31726654-8 2019 Either Sal-B or cisplatin treatment decreased tumor tissue levels of tumor necrosis factor (TNF-alpha), matrix metalloproteinase-8 (MMP-8), and Cyclin D1 in ESC treated mice. salvianolic acid B 7-12 matrix metallopeptidase 8 Mus musculus 104-130 31726654-8 2019 Either Sal-B or cisplatin treatment decreased tumor tissue levels of tumor necrosis factor (TNF-alpha), matrix metalloproteinase-8 (MMP-8), and Cyclin D1 in ESC treated mice. salvianolic acid B 7-12 matrix metallopeptidase 8 Mus musculus 132-137 31726654-8 2019 Either Sal-B or cisplatin treatment decreased tumor tissue levels of tumor necrosis factor (TNF-alpha), matrix metalloproteinase-8 (MMP-8), and Cyclin D1 in ESC treated mice. salvianolic acid B 7-12 cyclin D1 Mus musculus 144-153 31726654-10 2019 Immunohistochemical analysis revealed that Sal-B or cisplatin treatment increased the expression of the apoptotic markers caspase-3 and P53. salvianolic acid B 43-48 caspase 3 Mus musculus 122-131 31726654-10 2019 Immunohistochemical analysis revealed that Sal-B or cisplatin treatment increased the expression of the apoptotic markers caspase-3 and P53. salvianolic acid B 43-48 transformation related protein 53, pseudogene Mus musculus 136-139 31726654-11 2019 Although Sal-B or cisplatin significantly reduced the expression of the angiogenic factor vascular endothelial growth factor (VEGF) in ESC injected mice, only Sal-B reduced expression level of COX-2 in ESC injected mice. salvianolic acid B 9-14 vascular endothelial growth factor A Mus musculus 126-130 31726654-11 2019 Although Sal-B or cisplatin significantly reduced the expression of the angiogenic factor vascular endothelial growth factor (VEGF) in ESC injected mice, only Sal-B reduced expression level of COX-2 in ESC injected mice. salvianolic acid B 159-164 cytochrome c oxidase II, mitochondrial Mus musculus 193-198 31112902-0 2019 Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. salvianolic acid B 45-63 AKT serine/threonine kinase 1 Rattus norvegicus 103-106 31112902-0 2019 Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. salvianolic acid B 45-63 cAMP responsive element binding protein 1 Rattus norvegicus 107-111 31112902-0 2019 Anticonvulsant and anti-apoptosis effects of salvianolic acid B on pentylenetetrazole-kindled rats via AKT/CREB/BDNF signaling. salvianolic acid B 45-63 brain-derived neurotrophic factor Rattus norvegicus 112-116 31112902-15 2019 Thus, these data suggest that Sal B has anticonvulsant and anti-apoptotic effects in a PTZ-induced seizure model through activation of the AKT/CREB/BDNF signaling pathways. salvianolic acid B 30-35 AKT serine/threonine kinase 1 Rattus norvegicus 139-142 31112902-15 2019 Thus, these data suggest that Sal B has anticonvulsant and anti-apoptotic effects in a PTZ-induced seizure model through activation of the AKT/CREB/BDNF signaling pathways. salvianolic acid B 30-35 cAMP responsive element binding protein 1 Rattus norvegicus 143-147 31112902-15 2019 Thus, these data suggest that Sal B has anticonvulsant and anti-apoptotic effects in a PTZ-induced seizure model through activation of the AKT/CREB/BDNF signaling pathways. salvianolic acid B 30-35 brain-derived neurotrophic factor Rattus norvegicus 148-152 31173197-5 2019 Finally, Sal B increased the phosphorylation of AMP kinase (AMPK) and decreased the phosphorylation of mammalian target of rapamycin (mTOR), but had no effect on the phosphorylation of AKT. salvianolic acid B 9-14 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 60-64 31173197-5 2019 Finally, Sal B increased the phosphorylation of AMP kinase (AMPK) and decreased the phosphorylation of mammalian target of rapamycin (mTOR), but had no effect on the phosphorylation of AKT. salvianolic acid B 9-14 mechanistic target of rapamycin kinase Homo sapiens 103-132 31173197-4 2019 Furthermore, as an underlying mechanism, the enhancement of autophagy was indicated to be accountable for the decrease in apoptosis, as Sal B caused the upregulation of light chain 3-II and Beclin-1, and downregulation of p62 under H2O2-induced oxidative stress. salvianolic acid B 136-141 beclin 1 Homo sapiens 190-198 31173197-5 2019 Finally, Sal B increased the phosphorylation of AMP kinase (AMPK) and decreased the phosphorylation of mammalian target of rapamycin (mTOR), but had no effect on the phosphorylation of AKT. salvianolic acid B 9-14 mechanistic target of rapamycin kinase Homo sapiens 134-138 31173197-5 2019 Finally, Sal B increased the phosphorylation of AMP kinase (AMPK) and decreased the phosphorylation of mammalian target of rapamycin (mTOR), but had no effect on the phosphorylation of AKT. salvianolic acid B 9-14 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 48-58 31173197-6 2019 In conclusion, the present study revealed that Sal B protects HUVECs from oxidative stress, at least partially by promoting autophagy via activation of the AMPK pathway and downregulation of the mTOR pathway. salvianolic acid B 47-52 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 156-160 31173197-6 2019 In conclusion, the present study revealed that Sal B protects HUVECs from oxidative stress, at least partially by promoting autophagy via activation of the AMPK pathway and downregulation of the mTOR pathway. salvianolic acid B 47-52 mechanistic target of rapamycin kinase Homo sapiens 195-199 31223479-0 2019 Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy. salvianolic acid B 21-39 synuclein, alpha Mus musculus 48-63 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 tumor protein p53 Homo sapiens 134-137 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 H3 histone pseudogene 16 Homo sapiens 142-145 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 C-C motif chemokine ligand 2 Homo sapiens 205-210 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 interleukin 6 Homo sapiens 212-216 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 tumor necrosis factor Homo sapiens 221-230 31022596-10 2019 And also, the inhibitory effects of Sal-B on NF-kappaB and JNK pathways were abolished by miR-142-3p silence. salvianolic acid B 36-41 mitogen-activated protein kinase 8 Homo sapiens 59-62 31022596-12 2019 The anti-RA potential of Sal-B might be via up-regulating miR-142-3p, and subsequently modulating NF-kappaB and JNK pathways. salvianolic acid B 25-30 mitogen-activated protein kinase 8 Homo sapiens 112-115 30904623-0 2019 Salvianolic acid B ameliorates liver injury in a murine aGvHD model by decreasing inflammatory responses via upregulation of HO-1. salvianolic acid B 0-18 heme oxygenase 1 Mus musculus 125-129 30904623-8 2019 Furthermore, Sal B treatment also enhanced PGC-1alpha expression in liver tissue and HO-1 expression in nonparenchymal cells. salvianolic acid B 13-18 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 43-53 30904623-8 2019 Furthermore, Sal B treatment also enhanced PGC-1alpha expression in liver tissue and HO-1 expression in nonparenchymal cells. salvianolic acid B 13-18 heme oxygenase 1 Mus musculus 85-89 30904623-10 2019 These results indicated that the protective effect of Sal B relies on suppressing the inflammatory response phase in the aGvHD model, presumably by inducing HO-1. salvianolic acid B 54-59 heme oxygenase 1 Mus musculus 157-161 30904623-11 2019 Taken together our data showed that Sal B ameliorates liver injury in aGvHD by decreasing inflammatory responses via upregulation of HO-1. salvianolic acid B 36-41 heme oxygenase 1 Mus musculus 133-137 31223479-6 2019 In both cell-free and cellular models of alpha-synuclein aggregation, after administration of DHM and Sal B, we observed significant inhibition of alpha-synuclein accumulation and aggregation. salvianolic acid B 102-107 synuclein, alpha Mus musculus 41-56 31223479-6 2019 In both cell-free and cellular models of alpha-synuclein aggregation, after administration of DHM and Sal B, we observed significant inhibition of alpha-synuclein accumulation and aggregation. salvianolic acid B 102-107 synuclein, alpha Mus musculus 147-162 31223479-12 2019 Conclusions: Our data indicate that DHM and Sal B are effective in modulating alpha-synuclein accumulation and aggregate formation and augmenting activation of CMA, holding potential for the treatment of Parkinson"s disease. salvianolic acid B 44-49 synuclein, alpha Mus musculus 78-93 30402894-5 2019 Finally, we established an HEK239T-OATP1B1 cell model to confirm whether OATP1B1 mediated the transport of SAB. salvianolic acid B 107-110 solute carrier organic anion transporter family member 1B1 Homo sapiens 73-80 30907511-7 2019 Notably, the Sal B induced up-expression of TAZ was blocked by U0126 (the MEK-ERK inhibitor), rather than LY294002 (the PI3K-Akt inhibitor). salvianolic acid B 13-18 mitogen-activated protein kinase kinase 7 Homo sapiens 74-77 30907511-7 2019 Notably, the Sal B induced up-expression of TAZ was blocked by U0126 (the MEK-ERK inhibitor), rather than LY294002 (the PI3K-Akt inhibitor). salvianolic acid B 13-18 mitogen-activated protein kinase 1 Homo sapiens 78-81 30907511-7 2019 Notably, the Sal B induced up-expression of TAZ was blocked by U0126 (the MEK-ERK inhibitor), rather than LY294002 (the PI3K-Akt inhibitor). salvianolic acid B 13-18 AKT serine/threonine kinase 1 Homo sapiens 125-128 30907511-8 2019 Moreover, Sal B increased the p-ERK/ERK ratio to regulate the TAZ expression as well as the cell differentiation. salvianolic acid B 10-15 mitogen-activated protein kinase 1 Homo sapiens 32-35 30907511-8 2019 Moreover, Sal B increased the p-ERK/ERK ratio to regulate the TAZ expression as well as the cell differentiation. salvianolic acid B 10-15 mitogen-activated protein kinase 1 Homo sapiens 36-39 30907511-9 2019 In summary, this study suggests for the first time that Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis by activating MEK-ERK signalling pathway, which provides evidence for Sal B to be used as a potential therapeutic agent for the management of bone diseases. salvianolic acid B 56-61 mitogen-activated protein kinase kinase 7 Homo sapiens 139-142 30907511-9 2019 In summary, this study suggests for the first time that Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis by activating MEK-ERK signalling pathway, which provides evidence for Sal B to be used as a potential therapeutic agent for the management of bone diseases. salvianolic acid B 56-61 mitogen-activated protein kinase 1 Homo sapiens 143-146 30907511-9 2019 In summary, this study suggests for the first time that Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis by activating MEK-ERK signalling pathway, which provides evidence for Sal B to be used as a potential therapeutic agent for the management of bone diseases. salvianolic acid B 195-200 mitogen-activated protein kinase kinase 7 Homo sapiens 139-142 30907511-9 2019 In summary, this study suggests for the first time that Sal B targets TAZ to facilitate osteogenesis and reduce adipogenesis by activating MEK-ERK signalling pathway, which provides evidence for Sal B to be used as a potential therapeutic agent for the management of bone diseases. salvianolic acid B 195-200 mitogen-activated protein kinase 1 Homo sapiens 143-146 31353549-0 2019 Salvianolic acid B abolished chronic mild stress-induced depression through suppressing oxidative stress and neuro-inflammation via regulating NLRP3 inflammasome activation. salvianolic acid B 0-18 NLR family, pyrin domain containing 3 Rattus norvegicus 143-148 31353549-6 2019 Furthermore, the protein expression of NLRP3 (inflammasome) was markedly downregulated upon treatment with SB (both 20 and 40 mg) or IMP and thereby confirming its potent anti-depressant activity. salvianolic acid B 107-109 NLR family, pyrin domain containing 3 Rattus norvegicus 39-44 30535483-0 2019 Salvianolic acid B, an antioxidant derived from Salvia militarize, protects mice against gamma-radiation-induced damage through Nrf2/Bach1. salvianolic acid B 0-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 128-132 30535483-0 2019 Salvianolic acid B, an antioxidant derived from Salvia militarize, protects mice against gamma-radiation-induced damage through Nrf2/Bach1. salvianolic acid B 0-18 BTB and CNC homology 1, basic leucine zipper transcription factor 1 Mus musculus 133-138 31031620-11 2019 Salvianolic-acid B (SA-B), a water-soluble element of Salvia miltiorrhiza known to have anti-fibrosis effects, attenuated both basal and TGF-beta1-induced increased levels of MEF2A and C mRNA and protein. salvianolic acid B 0-18 SH3 domain binding protein 5 Homo sapiens 20-24 31031620-11 2019 Salvianolic-acid B (SA-B), a water-soluble element of Salvia miltiorrhiza known to have anti-fibrosis effects, attenuated both basal and TGF-beta1-induced increased levels of MEF2A and C mRNA and protein. salvianolic acid B 0-18 transforming growth factor beta 1 Homo sapiens 137-146 31031620-11 2019 Salvianolic-acid B (SA-B), a water-soluble element of Salvia miltiorrhiza known to have anti-fibrosis effects, attenuated both basal and TGF-beta1-induced increased levels of MEF2A and C mRNA and protein. salvianolic acid B 0-18 myocyte enhancer factor 2a Rattus norvegicus 175-180 30402894-6 2019 Results showed that the uptake kinetic parameters Vmax and Km for SAB in HepG2 cells were 21.28 +- 2.06 pmol mg-1 per protein min-1 and 28.47 +- 7.36 muM, respectively. salvianolic acid B 66-69 CD59 molecule (CD59 blood group) Homo sapiens 126-131 30402894-10 2019 In conclusion, this study demonstrated that OATP1B1 contributes to the transport and accumulation of SAB in the liver. salvianolic acid B 101-104 solute carrier organic anion transporter family member 1B1 Homo sapiens 44-51 30989958-2 2019 The objective of this study was to investigate the efficacy of cell penetrating peptide TAT-modified liposomes loaded with salvianolic acid B( SAB-TAT-LIP) on proliferation,migration and cell cycle of human skin fibroblasts( HSF),and preliminarily evaluate its effect on prevention and treatment of HS. salvianolic acid B 123-141 interleukin 6 Homo sapiens 225-228 30291890-0 2018 Salvianolic acid B as an anti-emphysema agent I: In vitro stimulation of lung cell proliferation and migration, and protection against lung cell death, and in vivo lung STAT3 activation and VEGF elevation. salvianolic acid B 0-18 signal transducer and activator of transcription 3 Rattus norvegicus 169-174 30291890-0 2018 Salvianolic acid B as an anti-emphysema agent I: In vitro stimulation of lung cell proliferation and migration, and protection against lung cell death, and in vivo lung STAT3 activation and VEGF elevation. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 190-194 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 44-62 vascular endothelial growth factor A Rattus norvegicus 308-312 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 44-62 signal transducer and activator of transcription 3 Rattus norvegicus 234-284 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 44-62 signal transducer and activator of transcription 3 Rattus norvegicus 286-291 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 64-69 signal transducer and activator of transcription 3 Rattus norvegicus 234-284 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 27-45 vascular endothelial growth factor A Rattus norvegicus 175-179 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 64-69 signal transducer and activator of transcription 3 Rattus norvegicus 286-291 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 27-45 Janus kinase 2 Rattus norvegicus 220-234 30193865-3 2018 Our previous in vitro study identified that salvianolic acid B (Sal-B), a polyphenol of traditional Chinese herbal danshen, stimulated lung cell proliferation and migration, and protected against induced lung cell death, by virtue of signal transducer and activator of transcription 3 (STAT3) activation and VEGF stimulation/elevation. salvianolic acid B 64-69 vascular endothelial growth factor A Rattus norvegicus 308-312 30193865-10 2018 In the PPE-induced model, Sal-B reduced induction of lung"s matrix metalloproteinase (MMP)-9 and MMP-2 activities by 59 and 94%, respectively, and restored pSTAT3 and VEGF expressions to the healthy lung levels, while leaving neutrophil accumulation unchecked [myeloperoxidase (MPO) activity]. salvianolic acid B 26-31 matrix metallopeptidase 9 Rattus norvegicus 60-92 30193865-10 2018 In the PPE-induced model, Sal-B reduced induction of lung"s matrix metalloproteinase (MMP)-9 and MMP-2 activities by 59 and 94%, respectively, and restored pSTAT3 and VEGF expressions to the healthy lung levels, while leaving neutrophil accumulation unchecked [myeloperoxidase (MPO) activity]. salvianolic acid B 26-31 matrix metallopeptidase 2 Rattus norvegicus 97-102 30193865-10 2018 In the PPE-induced model, Sal-B reduced induction of lung"s matrix metalloproteinase (MMP)-9 and MMP-2 activities by 59 and 94%, respectively, and restored pSTAT3 and VEGF expressions to the healthy lung levels, while leaving neutrophil accumulation unchecked [myeloperoxidase (MPO) activity]. salvianolic acid B 26-31 vascular endothelial growth factor A Rattus norvegicus 167-171 30193865-10 2018 In the PPE-induced model, Sal-B reduced induction of lung"s matrix metalloproteinase (MMP)-9 and MMP-2 activities by 59 and 94%, respectively, and restored pSTAT3 and VEGF expressions to the healthy lung levels, while leaving neutrophil accumulation unchecked [myeloperoxidase (MPO) activity]. salvianolic acid B 26-31 myeloperoxidase Rattus norvegicus 261-276 30193865-10 2018 In the PPE-induced model, Sal-B reduced induction of lung"s matrix metalloproteinase (MMP)-9 and MMP-2 activities by 59 and 94%, respectively, and restored pSTAT3 and VEGF expressions to the healthy lung levels, while leaving neutrophil accumulation unchecked [myeloperoxidase (MPO) activity]. salvianolic acid B 26-31 myeloperoxidase Rattus norvegicus 278-281 30193865-12 2018 These results provide an in vivo proof-of-concept for Sal-B as one of the first anti-emphysema agents enabling reversal of alveolar structural destruction and loss via local lung treatment by virtue of its STAT3 activation and VEGF stimulation. salvianolic acid B 54-59 signal transducer and activator of transcription 3 Rattus norvegicus 206-211 30193865-12 2018 These results provide an in vivo proof-of-concept for Sal-B as one of the first anti-emphysema agents enabling reversal of alveolar structural destruction and loss via local lung treatment by virtue of its STAT3 activation and VEGF stimulation. salvianolic acid B 54-59 vascular endothelial growth factor A Rattus norvegicus 227-231 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 27-45 Janus kinase 2 Rattus norvegicus 236-240 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 27-45 signal transducer and activator of transcription 3 Rattus norvegicus 246-296 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 27-45 signal transducer and activator of transcription 3 Rattus norvegicus 298-303 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 47-52 vascular endothelial growth factor A Rattus norvegicus 175-179 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 47-52 Janus kinase 2 Rattus norvegicus 220-234 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 47-52 Janus kinase 2 Rattus norvegicus 236-240 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 47-52 signal transducer and activator of transcription 3 Rattus norvegicus 246-296 30291890-3 2018 Thus, we hypothesized that salvianolic acid B (Sal-B), a polyphenol in traditional Chinese herbal danshen, is an alveolar structural recovery agent for emphysema by virtue of VEGF stimulation/elevation via activation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3), as stimulating lung cell proliferation and migration, and protecting against lung cell death. salvianolic acid B 47-52 signal transducer and activator of transcription 3 Rattus norvegicus 298-303 30291890-9 2018 In rats, Sal-B at 0.2 mg/kg enabled 1.9 and 1.5-fold increased STAT3 phosphorylation and VEGF elevation in the lungs, respectively, while causing no functional and morphological abnormalities. salvianolic acid B 9-14 signal transducer and activator of transcription 3 Rattus norvegicus 63-68 30291890-9 2018 In rats, Sal-B at 0.2 mg/kg enabled 1.9 and 1.5-fold increased STAT3 phosphorylation and VEGF elevation in the lungs, respectively, while causing no functional and morphological abnormalities. salvianolic acid B 9-14 vascular endothelial growth factor A Rattus norvegicus 89-93 30291890-10 2018 Hence, Sal-B was projected to be a new class of anti-emphysema agent capable of reversing alveolar structural destruction/loss via JAK2/STAT3/VEGF-dependent stimulation of lung cell proliferation and migration, and inhibition of induced lung cell death. salvianolic acid B 7-12 Janus kinase 2 Rattus norvegicus 131-135 30291890-10 2018 Hence, Sal-B was projected to be a new class of anti-emphysema agent capable of reversing alveolar structural destruction/loss via JAK2/STAT3/VEGF-dependent stimulation of lung cell proliferation and migration, and inhibition of induced lung cell death. salvianolic acid B 7-12 signal transducer and activator of transcription 3 Rattus norvegicus 136-141 30291890-10 2018 Hence, Sal-B was projected to be a new class of anti-emphysema agent capable of reversing alveolar structural destruction/loss via JAK2/STAT3/VEGF-dependent stimulation of lung cell proliferation and migration, and inhibition of induced lung cell death. salvianolic acid B 7-12 vascular endothelial growth factor A Rattus norvegicus 142-146 29782791-1 2018 Studies have shown that salvianolic acid B (SAB), which is derived from Chinese salvia ( Salvia miltiorrhiza), a plant used in traditional Chinese medicine, can promote the proliferation and migration of endothelial cells. salvianolic acid B 24-42 SH3 domain binding protein 5 Homo sapiens 44-47 30555632-0 2018 Antitumor properties of Salvianolic acid B against triple-negative and hormone receptor-positive breast cancer cells via ceramide-mediated apoptosis. salvianolic acid B 24-42 nuclear receptor subfamily 4 group A member 1 Homo sapiens 71-87 30257337-0 2018 Salvianolic acid B renders glioma cells more sensitive to radiation via Fis-1-mediated mitochondrial dysfunction. salvianolic acid B 0-18 fission, mitochondrial 1 Homo sapiens 72-77 30257337-9 2018 Furthermore, downregulation of the fission protein Fis-1 using siRNA was found to partially reversed the SalB-induced effects on cell viability, apoptosis and mitochondrial fission in U87 cells. salvianolic acid B 105-109 fission, mitochondrial 1 Homo sapiens 51-56 30257337-10 2018 In conclusion, our results suggest that a subthreshold dose of SalB renders glioma cells more sensitive to radiation via Fis-1-mediated mitochondrial dysfunction, and radiotherapy combined with SalB might be a novel treatment for glioma patients. salvianolic acid B 63-67 fission, mitochondrial 1 Homo sapiens 121-126 29966698-0 2018 Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways. salvianolic acid B 21-39 NFE2 like bZIP transcription factor 2 Rattus norvegicus 94-98 29966698-0 2018 Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2- and SIRT1-dependent pathways. salvianolic acid B 21-39 sirtuin 1 Rattus norvegicus 104-109 29966698-6 2018 Moreover, SalB dramatically induced nuclear factor-erythroid 2-related factor 2 (Nrf2) nuclear translocation and increased expression of heme oxygenase-1 and NADPH: quinine oxidoreductase-1. salvianolic acid B 10-14 NFE2 like bZIP transcription factor 2 Rattus norvegicus 81-85 29966698-6 2018 Moreover, SalB dramatically induced nuclear factor-erythroid 2-related factor 2 (Nrf2) nuclear translocation and increased expression of heme oxygenase-1 and NADPH: quinine oxidoreductase-1. salvianolic acid B 10-14 heme oxygenase 1 Rattus norvegicus 137-189 29966698-7 2018 In a mouse model of SAH, Nrf2 knockout significantly reversed the antioxidant effects of SalB against SAH. salvianolic acid B 89-93 nuclear factor, erythroid derived 2, like 2 Mus musculus 25-29 29966698-12 2018 Taken together, these in vivo and in vitro findings suggest that SalB provides protection against SAH-triggered oxidative damage by upregulating the Nrf2 antioxidant signaling pathway, which may be modulated by SIRT1 activation. salvianolic acid B 65-69 NFE2 like bZIP transcription factor 2 Rattus norvegicus 149-153 29966698-12 2018 Taken together, these in vivo and in vitro findings suggest that SalB provides protection against SAH-triggered oxidative damage by upregulating the Nrf2 antioxidant signaling pathway, which may be modulated by SIRT1 activation. salvianolic acid B 65-69 sirtuin 1 Rattus norvegicus 211-216 29751125-12 2018 In particular, lithospermic acid (7) and SalB markedly downregulated the expressions of TLR4, p-p65, and p-IkappaBalpha induced by LPS in THP-1 macrophages. salvianolic acid B 41-45 GLI family zinc finger 2 Homo sapiens 138-143 29789538-0 2018 Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1alpha signaling pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Homo sapiens 90-93 29795391-5 2018 Among these compounds, salvianolic acid A and C antagonized the activity of both P2Y1 and P2Y12 receptors in the low microM range, while salvianolic acid B antagonized the P2Y12 receptor. salvianolic acid B 137-155 purinergic receptor P2Y12 Homo sapiens 172-177 29789538-0 2018 Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1alpha signaling pathway. salvianolic acid B 0-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 94-104 29789538-4 2018 In the present study, we performed next-generation sequencing (NGS) profiling in the same animal model and found Sal-B treatment evoked a general downregulation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and hypoxia inducible factor 1alpha subunit (HIF-1alpha) signaling pathways, which might contribute to Sal-B"s metabolic modulation activity. salvianolic acid B 113-118 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 168-214 29789538-4 2018 In the present study, we performed next-generation sequencing (NGS) profiling in the same animal model and found Sal-B treatment evoked a general downregulation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and hypoxia inducible factor 1alpha subunit (HIF-1alpha) signaling pathways, which might contribute to Sal-B"s metabolic modulation activity. salvianolic acid B 113-118 hypoxia inducible factor 1 subunit alpha Homo sapiens 226-265 29789538-4 2018 In the present study, we performed next-generation sequencing (NGS) profiling in the same animal model and found Sal-B treatment evoked a general downregulation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and hypoxia inducible factor 1alpha subunit (HIF-1alpha) signaling pathways, which might contribute to Sal-B"s metabolic modulation activity. salvianolic acid B 113-118 hypoxia inducible factor 1 subunit alpha Homo sapiens 267-277 29789538-6 2018 Rescue assays suggested that compared with Sal-B treatment group, Akt or hif-1a overexpression attenuated the inhibitory effect of Sal-B on glucose uptake and intracellular lactate level. salvianolic acid B 131-136 AKT serine/threonine kinase 1 Homo sapiens 66-69 29789538-6 2018 Rescue assays suggested that compared with Sal-B treatment group, Akt or hif-1a overexpression attenuated the inhibitory effect of Sal-B on glucose uptake and intracellular lactate level. salvianolic acid B 131-136 hypoxia inducible factor 1 subunit alpha Homo sapiens 73-79 29789538-7 2018 Taken together, our results suggested that Sal-B modulated aberrant glucose metabolism via the PI3K/AKT/HIF-1alpha signaling pathways, which might contribute to the anti-carcinogenic activity of Sal-B. salvianolic acid B 43-48 AKT serine/threonine kinase 1 Homo sapiens 100-103 29789538-7 2018 Taken together, our results suggested that Sal-B modulated aberrant glucose metabolism via the PI3K/AKT/HIF-1alpha signaling pathways, which might contribute to the anti-carcinogenic activity of Sal-B. salvianolic acid B 43-48 hypoxia inducible factor 1 subunit alpha Homo sapiens 104-114 29434992-0 2018 Salvianolic acid B suppresses cell proliferation and induces apoptosis in osteosarcoma through p38-mediated reactive oxygen species generation. salvianolic acid B 0-18 mitogen-activated protein kinase 14 Homo sapiens 95-98 29257241-0 2018 Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway. salvianolic acid B 0-18 signal transducer and activator of transcription 3 Rattus norvegicus 117-122 29257241-0 2018 Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 123-127 29257241-4 2018 Salvianolic acid B was identified to recover cognitive deficits and neurocytes, reduce inflammation, oxidative stress and neurocyte apoptosis (caspase-3 and Bax protein expression) in cerebral small vessel disease rats. salvianolic acid B 0-18 caspase 3 Rattus norvegicus 143-152 29257241-4 2018 Salvianolic acid B was identified to recover cognitive deficits and neurocytes, reduce inflammation, oxidative stress and neurocyte apoptosis (caspase-3 and Bax protein expression) in cerebral small vessel disease rats. salvianolic acid B 0-18 BCL2 associated X, apoptosis regulator Rattus norvegicus 157-160 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 signal transducer and activator of transcription 3 Rattus norvegicus 44-94 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 signal transducer and activator of transcription 3 Rattus norvegicus 96-101 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 vascular endothelial growth factor A Rattus norvegicus 151-185 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 vascular endothelial growth factor A Rattus norvegicus 187-191 29257241-5 2018 In addition, salvianolic acid B upregulated signal transducer and activator of transcription 3 (STAT3) phosphorylation protein expression, and induced vascular endothelial growth factor (VEGF) and VEGF receptor 2 protein expression in cerebral small vessel disease rats. salvianolic acid B 13-31 vascular endothelial growth factor A Rattus norvegicus 197-201 29256825-0 2018 Salvianolic Acid B Enhances Hepatic Differentiation of Human Embryonic Stem Cells Through Upregulation of WNT Pathway and Inhibition of Notch Pathway. salvianolic acid B 0-18 notch receptor 1 Homo sapiens 136-141 29256825-11 2018 In conclusion, our study demonstrated that Sal B enhanced hepatocyte differentiation from human ESCs through activation of Wnt pathway and inhibition of Notch pathway. salvianolic acid B 43-48 notch receptor 1 Homo sapiens 153-158 29434992-2 2018 Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. salvianolic acid B 0-18 mitogen-activated protein kinase 14 Homo sapiens 172-239 29434992-2 2018 Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. salvianolic acid B 0-18 mitogen-activated protein kinase 14 Homo sapiens 243-246 29434992-2 2018 Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. salvianolic acid B 0-18 tumor protein p53 Homo sapiens 272-275 29434992-2 2018 Salvianolic acid B suppressed osteosarcoma cell proliferation and induced apoptosis in the osteosarcoma MG63 cell line, and activated the expressions of cleaved caspase-3, phosphorylated-tumor protein (p)38 mitogen-activated protein kinase (p-p38 MAPK) and phosphorylated-p53 (p-p53) proteins in the MG63 cells. salvianolic acid B 0-18 tumor protein p53 Homo sapiens 279-282 29434992-4 2018 The silencing of p38 expression inhibited the anticancer effect of salvianolic acid B on the levels of cell proliferation, p-p53 protein expression and ROS generation level in the MG63 cells. salvianolic acid B 67-85 mitogen-activated protein kinase 14 Homo sapiens 17-20 29434992-4 2018 The silencing of p38 expression inhibited the anticancer effect of salvianolic acid B on the levels of cell proliferation, p-p53 protein expression and ROS generation level in the MG63 cells. salvianolic acid B 67-85 tumor protein p53 Homo sapiens 125-128 29434992-5 2018 All these data supported the hypothesis that the anticancer effect of salvianolic acid B includes the suppression of cell proliferation and induces apoptosis in MG63 cells, and that p38 is important in the anticancer effect of salvianolic acid B on osteosarcoma cells due to the direct regulation of ROS generation. salvianolic acid B 227-245 mitogen-activated protein kinase 14 Homo sapiens 182-185 29434992-6 2018 These data suggest that salvianolic acid B is important in the proliferation of osteosarcoma cells due to the direct regulation of p38-mediated ROS signaling. salvianolic acid B 24-42 mitogen-activated protein kinase 14 Homo sapiens 131-134 29108993-0 2018 Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2. salvianolic acid B 0-18 NFE2 like bZIP transcription factor 2 Homo sapiens 123-127 29180227-5 2018 Over activation of astrocytes and microglia were inhibited by Sal B as shown by immunostaining of GFAP and Iba 1. salvianolic acid B 62-67 glial fibrillary acidic protein Homo sapiens 98-102 29180227-5 2018 Over activation of astrocytes and microglia were inhibited by Sal B as shown by immunostaining of GFAP and Iba 1. salvianolic acid B 62-67 allograft inflammatory factor 1 Homo sapiens 107-112 29224910-0 2017 Regulation of SIRT3/FOXO1 Signaling Pathway in Rats with Non-alcoholic Steatohepatitis by Salvianolic Acid B. salvianolic acid B 90-108 sirtuin 3 Rattus norvegicus 14-19 28966669-5 2017 The increase in ALP activity was more pronounced when induction was combined with the osteogenic inducer, Sal B, which enhanced the expression of OPG; however, Sal B reduced the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) by MSCs. salvianolic acid B 106-111 TNF receptor superfamily member 11B Rattus norvegicus 146-149 28966669-5 2017 The increase in ALP activity was more pronounced when induction was combined with the osteogenic inducer, Sal B, which enhanced the expression of OPG; however, Sal B reduced the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) by MSCs. salvianolic acid B 160-165 TNF superfamily member 11 Rattus norvegicus 192-242 28966669-5 2017 The increase in ALP activity was more pronounced when induction was combined with the osteogenic inducer, Sal B, which enhanced the expression of OPG; however, Sal B reduced the expression of receptor activator of nuclear factor-kappaB ligand (RANKL) by MSCs. salvianolic acid B 160-165 TNF superfamily member 11 Rattus norvegicus 244-249 28966669-6 2017 Sal B reversed the inhibitory effect of N-nitro L-arginine methylester on the MSCs and increased ALP activity, OCN content and the OPG/RANKL ratio. salvianolic acid B 0-5 bone gamma-carboxyglutamate protein Rattus norvegicus 111-114 28966669-6 2017 Sal B reversed the inhibitory effect of N-nitro L-arginine methylester on the MSCs and increased ALP activity, OCN content and the OPG/RANKL ratio. salvianolic acid B 0-5 TNF receptor superfamily member 11B Rattus norvegicus 131-134 28966669-6 2017 Sal B reversed the inhibitory effect of N-nitro L-arginine methylester on the MSCs and increased ALP activity, OCN content and the OPG/RANKL ratio. salvianolic acid B 0-5 TNF superfamily member 11 Rattus norvegicus 135-140 28244648-6 2017 The passaged chondrocytes treated with Sal B showed strengthened cellular synthesis and stabilized mitochondrial membrane potential with upregulated expression of the marker genes for chondrocyte phenotype, Col2-alpha1, Acan and Sox9, the key Wnt signalling molecule beta-catenin and paracrine cytokine Cytl-1. salvianolic acid B 39-44 aggrecan Homo sapiens 220-224 28244648-6 2017 The passaged chondrocytes treated with Sal B showed strengthened cellular synthesis and stabilized mitochondrial membrane potential with upregulated expression of the marker genes for chondrocyte phenotype, Col2-alpha1, Acan and Sox9, the key Wnt signalling molecule beta-catenin and paracrine cytokine Cytl-1. salvianolic acid B 39-44 SRY-box transcription factor 9 Homo sapiens 229-233 28244648-6 2017 The passaged chondrocytes treated with Sal B showed strengthened cellular synthesis and stabilized mitochondrial membrane potential with upregulated expression of the marker genes for chondrocyte phenotype, Col2-alpha1, Acan and Sox9, the key Wnt signalling molecule beta-catenin and paracrine cytokine Cytl-1. salvianolic acid B 39-44 catenin beta 1 Homo sapiens 267-279 28244648-6 2017 The passaged chondrocytes treated with Sal B showed strengthened cellular synthesis and stabilized mitochondrial membrane potential with upregulated expression of the marker genes for chondrocyte phenotype, Col2-alpha1, Acan and Sox9, the key Wnt signalling molecule beta-catenin and paracrine cytokine Cytl-1. salvianolic acid B 39-44 cytokine like 1 Homo sapiens 303-309 28839433-1 2017 AIM: To investigate the capability of salvianolic acid B (Sal B) to protect hepatocytes from hydrogen peroxide (H2O2)/carbon tetrachloride (CCl4)-induced lysosomal membrane permeabilization. salvianolic acid B 38-56 C-C motif chemokine ligand 4 Homo sapiens 140-144 28839433-12 2017 Sal B attenuated H2O2-induced cell apoptosis and death, restored the inhibition of proliferation, decreased the amount of PCC, and stabilized the lysosome membrane by increasing the LAMP1 protein level and antagonizing CatB/D leakage into the cytosol. salvianolic acid B 0-5 lysosomal associated membrane protein 1 Homo sapiens 182-187 28839433-12 2017 Sal B attenuated H2O2-induced cell apoptosis and death, restored the inhibition of proliferation, decreased the amount of PCC, and stabilized the lysosome membrane by increasing the LAMP1 protein level and antagonizing CatB/D leakage into the cytosol. salvianolic acid B 0-5 tyrosinase related protein 1 Homo sapiens 219-223 28839433-14 2017 Furthermore, Sal B effectively rescued hepatocytes by increasing LAMP1 expression and by reducing lysosomal enzyme translocation to the cytosol. salvianolic acid B 13-18 lysosomal associated membrane protein 1 Homo sapiens 65-70 28839433-15 2017 CONCLUSION: Sal B protected mouse embryonic hepatocytes from H2O2/CCl4-induced injury/death by stabilizing the lysosomal membrane. salvianolic acid B 12-17 chemokine (C-C motif) ligand 4 Mus musculus 66-70 28800882-0 2017 Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential. salvianolic acid B 0-18 BCL2, apoptosis regulator Rattus norvegicus 105-110 28800882-5 2017 Preincubation with Sal B led to a significant decrease of caspase-9 and caspase-3 activity and poly ADP-ribose polymerase (PARP) cleavage. salvianolic acid B 19-24 caspase 9 Rattus norvegicus 58-67 28800882-5 2017 Preincubation with Sal B led to a significant decrease of caspase-9 and caspase-3 activity and poly ADP-ribose polymerase (PARP) cleavage. salvianolic acid B 19-24 caspase 3 Rattus norvegicus 72-81 28800882-5 2017 Preincubation with Sal B led to a significant decrease of caspase-9 and caspase-3 activity and poly ADP-ribose polymerase (PARP) cleavage. salvianolic acid B 19-24 poly (ADP-ribose) polymerase 1 Rattus norvegicus 95-121 28800882-5 2017 Preincubation with Sal B led to a significant decrease of caspase-9 and caspase-3 activity and poly ADP-ribose polymerase (PARP) cleavage. salvianolic acid B 19-24 poly (ADP-ribose) polymerase 1 Rattus norvegicus 123-127 28800882-8 2017 Taken together, these results indicate that Sal B is able to suppress intermittent high glucose-induced INS-1 cell apoptosis, which might be ascribed to regulation of Bcl-2 family protein expression and preservation of mitochondrial membrane potential. salvianolic acid B 44-49 BCL2, apoptosis regulator Rattus norvegicus 167-172 28603997-6 2017 SAA, SAB, DSI, and CDI, but not DSS, PA, and RA, significantly inhibited human UGT1A1-mediated bilirubin glucuronidation via a mixed-type inhibitory mechanism. salvianolic acid B 5-8 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 79-85 28603997-8 2017 In conclusion, SAA and its analog SAB are the main ingredients responsible for inhibition of bilirubin glucuronidation by DSI and CDI, whose use is associated with many high bilirubin-related ADR. salvianolic acid B 34-37 serum amyloid A1 cluster Homo sapiens 15-18 29224910-0 2017 Regulation of SIRT3/FOXO1 Signaling Pathway in Rats with Non-alcoholic Steatohepatitis by Salvianolic Acid B. salvianolic acid B 90-108 forkhead box O1 Rattus norvegicus 20-25 29224910-11 2017 CONCLUSION: Sal B can decrease oxidative stress reaction by regulating SIRT3/FOXO1 signaling pathway and play a therapeutic role in the treatment of NASH in rats. salvianolic acid B 12-17 sirtuin 3 Rattus norvegicus 71-76 29224910-11 2017 CONCLUSION: Sal B can decrease oxidative stress reaction by regulating SIRT3/FOXO1 signaling pathway and play a therapeutic role in the treatment of NASH in rats. salvianolic acid B 12-17 forkhead box O1 Rattus norvegicus 77-82 28753232-0 2017 Salvianolic Acid B Inhibits High-Fat Diet-Induced Inflammation by Activating the Nrf2 Pathway. salvianolic acid B 0-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 81-85 28753232-7 2017 These findings demonstrated that Sal B could effectively attenuate inflammation by activating the Nrf2-mediated antioxidant defense system. salvianolic acid B 33-38 nuclear factor, erythroid derived 2, like 2 Mus musculus 98-102 28396195-7 2017 Oral administration of Sal B reversed the Ang II-induced elevation of arterial systolic blood pressure in mice, augmented the impaired endothelium-dependent relaxations and attenuated the exaggerated endothelium-dependent contractions in both aortas and renal arteries of Ang II-infused mice. salvianolic acid B 23-28 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 42-48 28396195-7 2017 Oral administration of Sal B reversed the Ang II-induced elevation of arterial systolic blood pressure in mice, augmented the impaired endothelium-dependent relaxations and attenuated the exaggerated endothelium-dependent contractions in both aortas and renal arteries of Ang II-infused mice. salvianolic acid B 23-28 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 272-278 28396195-0 2017 Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice. salvianolic acid B 15-33 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 67-81 28396195-8 2017 In addition, Sal B treatment normalized the elevated levels of AT1 receptors, NADPH oxidase subunits (NOx-2 and NOx-4) and nitrotyrosine in arteries of Ang II-infused mice or in Ang II-treated HUVECs. salvianolic acid B 13-18 angiotensin II receptor, type 1a Mus musculus 63-66 28396195-2 2017 The present study examined the vasoprotective effect of Sal B in hypertensive mice induced by angiotensin II (Ang II). salvianolic acid B 56-61 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 94-108 28396195-8 2017 In addition, Sal B treatment normalized the elevated levels of AT1 receptors, NADPH oxidase subunits (NOx-2 and NOx-4) and nitrotyrosine in arteries of Ang II-infused mice or in Ang II-treated HUVECs. salvianolic acid B 13-18 cytochrome b-245, beta polypeptide Mus musculus 102-107 28396195-2 2017 The present study examined the vasoprotective effect of Sal B in hypertensive mice induced by angiotensin II (Ang II). salvianolic acid B 56-61 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 110-116 28396195-3 2017 Sal B (25mg/kg/day) was administered via oral gavage for 11days to Ang II (1.2mg/kg/day)-infused C57BL/6J mice (8-10weeks old). salvianolic acid B 0-5 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 67-73 28396195-8 2017 In addition, Sal B treatment normalized the elevated levels of AT1 receptors, NADPH oxidase subunits (NOx-2 and NOx-4) and nitrotyrosine in arteries of Ang II-infused mice or in Ang II-treated HUVECs. salvianolic acid B 13-18 NADPH oxidase 4 Mus musculus 112-117 28396195-8 2017 In addition, Sal B treatment normalized the elevated levels of AT1 receptors, NADPH oxidase subunits (NOx-2 and NOx-4) and nitrotyrosine in arteries of Ang II-infused mice or in Ang II-treated HUVECs. salvianolic acid B 13-18 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 152-158 28396195-8 2017 In addition, Sal B treatment normalized the elevated levels of AT1 receptors, NADPH oxidase subunits (NOx-2 and NOx-4) and nitrotyrosine in arteries of Ang II-infused mice or in Ang II-treated HUVECs. salvianolic acid B 13-18 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 178-184 28396195-9 2017 In summary, the present study provided additional evidence demonstrating that Sal B treatment for 11days reverses the impaired endothelial function and with a marked inhibition of AT1 receptor-dependent vascular oxidative stress. salvianolic acid B 78-83 angiotensin II receptor, type 1a Mus musculus 180-183 28495616-0 2017 Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca2+ overload in rat cardiomyocytes. salvianolic acid B 0-18 transient receptor potential cation channel, subfamily C, member 3 Rattus norvegicus 74-79 28495616-0 2017 Salvianolic acid B attenuates doxorubicin-induced ER stress by inhibiting TRPC3 and TRPC6 mediated Ca2+ overload in rat cardiomyocytes. salvianolic acid B 0-18 transient receptor potential cation channel, subfamily C, member 6 Rattus norvegicus 84-89 28495616-15 2017 These results indicate that Sal B protects against DOX-induced cardiac apoptosis and ER stress via TRPC3 and TRPC6 inhibition. salvianolic acid B 28-33 transient receptor potential cation channel, subfamily C, member 3 Rattus norvegicus 99-104 28495616-15 2017 These results indicate that Sal B protects against DOX-induced cardiac apoptosis and ER stress via TRPC3 and TRPC6 inhibition. salvianolic acid B 28-33 transient receptor potential cation channel, subfamily C, member 6 Rattus norvegicus 109-114 27915455-6 2017 Interestingly, we also found that the overexpression of AtEDT1 determined the accumulation of salvianolic acids, such as rosmarinic acid, lithospermic acid, salvianolic acid B, and total salvianolic acids due to the induction of the expression levels of salvianolic acid biosynthetic genes. salvianolic acid B 157-175 homeodomain GLABROUS 11 Arabidopsis thaliana 56-62 28254683-0 2017 Salvianolic acid B inhibits IL-1beta-induced inflammatory cytokine production in human osteoarthritis chondrocytes and has a protective effect in a mouse osteoarthritis model. salvianolic acid B 0-18 interleukin 1 beta Homo sapiens 28-36 28513773-0 2017 Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K/Akt signaling pathway. salvianolic acid B 52-70 AKT serine/threonine kinase 1 Rattus norvegicus 134-137 28513773-1 2017 Salvianolic acid B (SAB) is one the major phytocomponents of Radix Salvia miltiorrhiza and exhibit numerous health promoting properties. salvianolic acid B 0-18 SH3-domain binding protein 5 Rattus norvegicus 20-23 27989594-8 2017 SalB exerted anti-steatotic and anti-inflammatory effects against alcoholic liver injury by inducing SIRT1-mediated inhibition of CRP and ChREBP expression. salvianolic acid B 0-4 sirtuin 1 Rattus norvegicus 101-106 28214521-0 2017 Neuroprotective effect of salvianolic acid B against cerebral ischemic injury in rats via the CD40/NF-kappaB pathway associated with suppression of platelets activation and neuroinflammation. salvianolic acid B 26-44 CD40 molecule Rattus norvegicus 94-98 28214521-9 2017 The I/R-induced pro-inflammatory mediator mRNA and protein overexpression in the penumbra cortex, including ICAM-1, IL-1beta, IL-6, IL-8, and MCP-1, were significantly inhibited by SAB in a dose-dependent manner. salvianolic acid B 181-184 intercellular adhesion molecule 1 Rattus norvegicus 108-114 28214521-9 2017 The I/R-induced pro-inflammatory mediator mRNA and protein overexpression in the penumbra cortex, including ICAM-1, IL-1beta, IL-6, IL-8, and MCP-1, were significantly inhibited by SAB in a dose-dependent manner. salvianolic acid B 181-184 interleukin 1 beta Rattus norvegicus 116-124 28214521-9 2017 The I/R-induced pro-inflammatory mediator mRNA and protein overexpression in the penumbra cortex, including ICAM-1, IL-1beta, IL-6, IL-8, and MCP-1, were significantly inhibited by SAB in a dose-dependent manner. salvianolic acid B 181-184 mast cell protease 1-like 1 Rattus norvegicus 142-147 28214521-10 2017 Further studies suggested SAB treatment attenuated CD40 expression and NF-kappaB activation, which involved NF-kappaB/p65 phosphorylation and IkappaBalpha phosphorylation and degradation. salvianolic acid B 26-29 CD40 molecule Rattus norvegicus 51-55 28214521-10 2017 Further studies suggested SAB treatment attenuated CD40 expression and NF-kappaB activation, which involved NF-kappaB/p65 phosphorylation and IkappaBalpha phosphorylation and degradation. salvianolic acid B 26-29 synaptotagmin 1 Rattus norvegicus 118-121 28214521-11 2017 In conclusion, our findings indicated that the neuroprotective effects of SAB post cerebral I/R injury are associated with the inhibition of both platelets activation and production of pro-inflammatory mediators and the downregulation of the CD40/NF-kappaB pathway. salvianolic acid B 74-77 CD40 molecule Rattus norvegicus 242-246 28815250-1 2017 PURPOSE: To introduce the methods of triamcinolone acetonide (TA) and salvianolic acid B(SA-B) intralesional injection in the treatment of oral submucous fibrosis and evaluate the treatment effects. salvianolic acid B 70-88 SH3 domain binding protein 5 Homo sapiens 89-93 27989594-0 2017 Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats. salvianolic acid B 0-18 sirtuin 1 Rattus norvegicus 71-76 27989594-0 2017 Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats. salvianolic acid B 0-18 C-reactive protein Rattus norvegicus 100-103 27989594-8 2017 SalB exerted anti-steatotic and anti-inflammatory effects against alcoholic liver injury by inducing SIRT1-mediated inhibition of CRP and ChREBP expression. salvianolic acid B 0-4 C-reactive protein Rattus norvegicus 130-133 27989594-0 2017 Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats. salvianolic acid B 0-18 MLX interacting protein-like Rattus norvegicus 108-114 27989594-8 2017 SalB exerted anti-steatotic and anti-inflammatory effects against alcoholic liver injury by inducing SIRT1-mediated inhibition of CRP and ChREBP expression. salvianolic acid B 0-4 MLX interacting protein-like Rattus norvegicus 138-144 28352346-0 2017 Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARgamma expression in rats. salvianolic acid B 0-18 peroxisome proliferator-activated receptor gamma Rattus norvegicus 82-91 27989594-4 2017 Moreover, SalB treatment ameliorated ethanol-induced hepatic inflammation by decreasing the levels of hepatotoxic cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). salvianolic acid B 10-14 tumor necrosis factor Rattus norvegicus 132-159 27989594-4 2017 Moreover, SalB treatment ameliorated ethanol-induced hepatic inflammation by decreasing the levels of hepatotoxic cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). salvianolic acid B 10-14 tumor necrosis factor Rattus norvegicus 161-170 27989594-4 2017 Moreover, SalB treatment ameliorated ethanol-induced hepatic inflammation by decreasing the levels of hepatotoxic cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). salvianolic acid B 10-14 interleukin 6 Rattus norvegicus 176-189 27989594-4 2017 Moreover, SalB treatment ameliorated ethanol-induced hepatic inflammation by decreasing the levels of hepatotoxic cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). salvianolic acid B 10-14 interleukin 6 Rattus norvegicus 191-195 28352346-7 2017 Moreover, Sal B treatment suppressed peroxisome proliferator-activated receptor (PPAR)gamma and AP2 protein expression levels and increased runt-related transcription factor 2 and Collagen I protein expression levels in steroid-induced rats. salvianolic acid B 10-15 peroxisome proliferator-activated receptor gamma Rattus norvegicus 81-91 28352346-7 2017 Moreover, Sal B treatment suppressed peroxisome proliferator-activated receptor (PPAR)gamma and AP2 protein expression levels and increased runt-related transcription factor 2 and Collagen I protein expression levels in steroid-induced rats. salvianolic acid B 10-15 fatty acid binding protein 4 Rattus norvegicus 96-99 28352346-7 2017 Moreover, Sal B treatment suppressed peroxisome proliferator-activated receptor (PPAR)gamma and AP2 protein expression levels and increased runt-related transcription factor 2 and Collagen I protein expression levels in steroid-induced rats. salvianolic acid B 10-15 RUNX family transcription factor 2 Rattus norvegicus 140-175 28352346-8 2017 osteocalcin and alkaline phosphatase content in steroid-induced rats was enhanced by treatment with Sal B. salvianolic acid B 100-105 bone gamma-carboxyglutamate protein Rattus norvegicus 0-11 28352346-9 2017 These results suggest that Sal B prevents steroid-induced osteonecrosis of the femoral head via PPARgamma expression in rats. salvianolic acid B 27-32 peroxisome proliferator-activated receptor gamma Rattus norvegicus 96-105 28391277-5 2017 METHODS: Long intergenic noncoding RNA-p21 (lincRNA-p21) expression was detected in Salvianolic acid B (Sal B)-treated cells. salvianolic acid B 84-102 tumor protein p53 pathway corepressor 1 Homo sapiens 9-42 28116660-0 2017 Salvianolic acid B attenuates oxidized low-density lipoprotein-induced endothelial cell apoptosis through inhibition of oxidative stress, p53, and caspase-3 pathways. salvianolic acid B 0-18 tumor protein p53 Homo sapiens 138-141 28116660-0 2017 Salvianolic acid B attenuates oxidized low-density lipoprotein-induced endothelial cell apoptosis through inhibition of oxidative stress, p53, and caspase-3 pathways. salvianolic acid B 0-18 caspase 3 Homo sapiens 147-156 28116660-4 2017 The anti-apoptotic effect of Sal B was tested by Hoechst 33258 staining and Annexin V/propidium iodide flflow cytometry analysis. salvianolic acid B 29-34 annexin A5 Homo sapiens 76-85 28116660-10 2017 CONCLUSION: Sal B exhibited anti-apoptotic effects in ox-LDL-induced endothelial cell injury by suppressing oxidative stress, p53, and caspase-3. salvianolic acid B 12-17 tumor protein p53 Homo sapiens 126-129 28116660-10 2017 CONCLUSION: Sal B exhibited anti-apoptotic effects in ox-LDL-induced endothelial cell injury by suppressing oxidative stress, p53, and caspase-3. salvianolic acid B 12-17 caspase 3 Homo sapiens 135-144 28992623-0 2017 Salvianolic Acid B Ameliorates Cognitive Deficits Through IGF-1/Akt Pathway in Rats with Vascular Dementia. salvianolic acid B 0-18 insulin-like growth factor 1 Rattus norvegicus 58-63 28992623-0 2017 Salvianolic Acid B Ameliorates Cognitive Deficits Through IGF-1/Akt Pathway in Rats with Vascular Dementia. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 64-67 28391277-5 2017 METHODS: Long intergenic noncoding RNA-p21 (lincRNA-p21) expression was detected in Salvianolic acid B (Sal B)-treated cells. salvianolic acid B 84-102 tumor protein p53 pathway corepressor 1 Homo sapiens 44-55 28391277-5 2017 METHODS: Long intergenic noncoding RNA-p21 (lincRNA-p21) expression was detected in Salvianolic acid B (Sal B)-treated cells. salvianolic acid B 104-109 tumor protein p53 pathway corepressor 1 Homo sapiens 9-42 28391277-5 2017 METHODS: Long intergenic noncoding RNA-p21 (lincRNA-p21) expression was detected in Salvianolic acid B (Sal B)-treated cells. salvianolic acid B 104-109 tumor protein p53 pathway corepressor 1 Homo sapiens 44-55 28391277-8 2017 RESULTS: LincRNA-p21 expression was up-regulated in HSCs after Sal B treatment. salvianolic acid B 63-68 tumor protein p53 pathway corepressor 1 Homo sapiens 9-20 28391277-10 2017 Sal B-inhibited HSC activation including the reduction of cell proliferation, alpha-smooth muscle actin (alpha-SMA) and type I collagen was inhibited by lincRNA-p21 knockdown. salvianolic acid B 0-5 fucosyltransferase 1 (H blood group) Homo sapiens 16-19 28391277-10 2017 Sal B-inhibited HSC activation including the reduction of cell proliferation, alpha-smooth muscle actin (alpha-SMA) and type I collagen was inhibited by lincRNA-p21 knockdown. salvianolic acid B 0-5 tumor protein p53 pathway corepressor 1 Homo sapiens 153-164 28391277-11 2017 Sal B-induced Wnt/beta-catenin pathway inactivation was blocked down by loss of lincRNA-p21. salvianolic acid B 0-5 catenin beta 1 Homo sapiens 18-30 28391277-11 2017 Sal B-induced Wnt/beta-catenin pathway inactivation was blocked down by loss of lincRNA-p21. salvianolic acid B 0-5 tumor protein p53 pathway corepressor 1 Homo sapiens 80-91 28391277-15 2017 CONCLUSION: We demonstrate that lincRNA-p21-inhibited Wnt/beta-catenin pathway is involved in the effects of Sal B on HSC activation and lincRNA-p21 suppresses HSC activation, at least in part, via miR-17-5p-mediated-Wnt/beta-catenin pathway. salvianolic acid B 109-114 tumor protein p53 pathway corepressor 1 Homo sapiens 32-43 28391277-15 2017 CONCLUSION: We demonstrate that lincRNA-p21-inhibited Wnt/beta-catenin pathway is involved in the effects of Sal B on HSC activation and lincRNA-p21 suppresses HSC activation, at least in part, via miR-17-5p-mediated-Wnt/beta-catenin pathway. salvianolic acid B 109-114 catenin beta 1 Homo sapiens 58-70 28391277-15 2017 CONCLUSION: We demonstrate that lincRNA-p21-inhibited Wnt/beta-catenin pathway is involved in the effects of Sal B on HSC activation and lincRNA-p21 suppresses HSC activation, at least in part, via miR-17-5p-mediated-Wnt/beta-catenin pathway. salvianolic acid B 109-114 fucosyltransferase 1 (H blood group) Homo sapiens 118-121 28391277-15 2017 CONCLUSION: We demonstrate that lincRNA-p21-inhibited Wnt/beta-catenin pathway is involved in the effects of Sal B on HSC activation and lincRNA-p21 suppresses HSC activation, at least in part, via miR-17-5p-mediated-Wnt/beta-catenin pathway. salvianolic acid B 109-114 fucosyltransferase 1 (H blood group) Homo sapiens 160-163 28391277-15 2017 CONCLUSION: We demonstrate that lincRNA-p21-inhibited Wnt/beta-catenin pathway is involved in the effects of Sal B on HSC activation and lincRNA-p21 suppresses HSC activation, at least in part, via miR-17-5p-mediated-Wnt/beta-catenin pathway. salvianolic acid B 109-114 microRNA 17 Homo sapiens 198-207 28391277-15 2017 CONCLUSION: We demonstrate that lincRNA-p21-inhibited Wnt/beta-catenin pathway is involved in the effects of Sal B on HSC activation and lincRNA-p21 suppresses HSC activation, at least in part, via miR-17-5p-mediated-Wnt/beta-catenin pathway. salvianolic acid B 109-114 catenin beta 1 Homo sapiens 221-233 27852325-8 2016 The extent of the epidural scar, the regeneration of the vasculature and the expression levels of VEGF suggested better outcomes in the Sal B-treated groups. salvianolic acid B 136-141 vascular endothelial growth factor A Rattus norvegicus 98-102 28413985-0 2017 Decrease in the Generation of Amyloid-beta Due to Salvianolic Acid B by Modulating BACE1 Activity. salvianolic acid B 50-68 beta-secretase 1 Homo sapiens 83-88 28413985-5 2017 Using N2a-mouse and H4- human neuroglioma cell lines expressing SwedAPP, it was demonstrated that Sal B significantly and dose-dependently decreased the generation of extracellular Abeta, soluble APPbeta (by-product of APP cleaved by BACE1), and intracellular C-terminal fragment beta from APP without influencing alpha-secretase and gamma-secretase activity and the levels of FL-APP. salvianolic acid B 98-103 amyloid beta precursor protein Homo sapiens 181-186 28413985-5 2017 Using N2a-mouse and H4- human neuroglioma cell lines expressing SwedAPP, it was demonstrated that Sal B significantly and dose-dependently decreased the generation of extracellular Abeta, soluble APPbeta (by-product of APP cleaved by BACE1), and intracellular C-terminal fragment beta from APP without influencing alpha-secretase and gamma-secretase activity and the levels of FL-APP. salvianolic acid B 98-103 beta-secretase 1 Homo sapiens 234-239 28413985-8 2017 Our results indicate that Sal B is a BACE1 inhibitor and, as such, is a promising candidate for the treatment of AD. salvianolic acid B 26-31 beta-secretase 1 Homo sapiens 37-42 28123461-5 2017 Intravenous injection of high-dose ChA or CA (7 mg/kg) markedly increased the peroxide production in the venular walls and upregulated the protein expression levels of Nox4 and p22phox in the ileum tissues, while the same dose of CA and SAB made no difference within the observation period. salvianolic acid B 237-240 NADPH oxidase 4 Rattus norvegicus 168-172 27779641-0 2016 AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells. salvianolic acid B 42-60 AKT serine/threonine kinase 1 Homo sapiens 0-3 27779641-0 2016 AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells. salvianolic acid B 42-60 mechanistic target of rapamycin kinase Homo sapiens 4-8 27779641-7 2016 Overexpression of AKT abolished the effects of Sal B on HCC cells, suggesting a critical role of the AKT/mTOR signaling pathway in Sal B-induced biological effects. salvianolic acid B 47-52 AKT serine/threonine kinase 1 Homo sapiens 18-21 27779641-7 2016 Overexpression of AKT abolished the effects of Sal B on HCC cells, suggesting a critical role of the AKT/mTOR signaling pathway in Sal B-induced biological effects. salvianolic acid B 47-52 mechanistic target of rapamycin kinase Homo sapiens 105-109 27779641-9 2016 Moreover, the AKT/mTOR signaling pathway was involved in Sal B-induced autophagy, which promoted apoptosis. salvianolic acid B 57-62 AKT serine/threonine kinase 1 Homo sapiens 14-17 27779641-9 2016 Moreover, the AKT/mTOR signaling pathway was involved in Sal B-induced autophagy, which promoted apoptosis. salvianolic acid B 57-62 mechanistic target of rapamycin kinase Homo sapiens 18-22 27893819-0 2016 Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice. salvianolic acid B 0-18 mitogen-activated protein kinase 3 Mus musculus 60-66 27893819-0 2016 Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice. salvianolic acid B 0-18 GATA binding protein 4 Mus musculus 67-72 27614127-7 2016 Sal B effectively reduced vascular endothelial cell apoptosis, with Bcl-2 protein up-regulated and Bax protein down-regulated markedly. salvianolic acid B 0-5 BCL2, apoptosis regulator Rattus norvegicus 68-73 27614127-9 2016 Protein levels of NOX2 and NOX4, two main isoforms of NADPH oxidase known as the major source of reactive oxygen species in the vasculature, were markedly decreased in Sal B treated groups. salvianolic acid B 168-173 cytochrome b-245 beta chain Rattus norvegicus 18-22 27614127-7 2016 Sal B effectively reduced vascular endothelial cell apoptosis, with Bcl-2 protein up-regulated and Bax protein down-regulated markedly. salvianolic acid B 0-5 BCL2 associated X, apoptosis regulator Rattus norvegicus 99-102 27614127-9 2016 Protein levels of NOX2 and NOX4, two main isoforms of NADPH oxidase known as the major source of reactive oxygen species in the vasculature, were markedly decreased in Sal B treated groups. salvianolic acid B 168-173 NADPH oxidase 4 Rattus norvegicus 27-31 27827892-0 2016 Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1). salvianolic acid B 0-18 glutaredoxin Homo sapiens 124-138 27827892-0 2016 Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1). salvianolic acid B 0-18 glutaredoxin Homo sapiens 140-144 27827892-5 2016 In this study, we identified and characterized Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury. salvianolic acid B 47-65 glutaredoxin Homo sapiens 100-104 27827892-5 2016 In this study, we identified and characterized Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury. salvianolic acid B 67-72 glutaredoxin Homo sapiens 100-104 27827892-7 2016 Interestingly, we found Sal B pretreatment upregulated Grx1 expression in RPE cells in a time- and dose-dependent manner. salvianolic acid B 24-29 glutaredoxin Homo sapiens 55-59 27827892-9 2016 Further investigation showed that knockdown of Grx1 by small interfering RNA (siRNA) significantly reduced the protective effects of Sal B. salvianolic acid B 133-138 glutaredoxin Homo sapiens 47-51 27827892-10 2016 We conclude that Sal B protects RPE cells against H2O2-induced cell injury through Grx1 induction by activating Nrf2 pathway, thus preventing lethal accumulation of PSSG and reversing oxidative damage. salvianolic acid B 17-22 glutaredoxin Homo sapiens 83-87 27827892-10 2016 We conclude that Sal B protects RPE cells against H2O2-induced cell injury through Grx1 induction by activating Nrf2 pathway, thus preventing lethal accumulation of PSSG and reversing oxidative damage. salvianolic acid B 17-22 NFE2 like bZIP transcription factor 2 Homo sapiens 112-116 27507327-0 2016 Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling. salvianolic acid B 0-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 83-87 27507327-0 2016 Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling. salvianolic acid B 0-18 NADPH oxidase 4 Mus musculus 88-92 27507327-0 2016 Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling. salvianolic acid B 0-18 transforming growth factor, beta 1 Mus musculus 111-120 27507327-0 2016 Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling. salvianolic acid B 0-18 SMAD family member 3 Mus musculus 121-126 27569393-8 2016 Co-exposure to Sal B (0.2-2 mumol/L) dose-dependently increased the bone mineralization area and IOD in AB zebafish larvae and osteoblast fluorescence in tg (sp7:egfp) zebrafish larvae. salvianolic acid B 15-20 Sp7 transcription factor Danio rerio 158-161 28326703-6 2016 The ALP activity and OCN mRNA expression levels of hPDLCs were both significantly improved (P<0.05) under treatment with different Sal B concentrations (0.5, 1, and 5 mumol L-1) compared with those in OIM group. salvianolic acid B 134-139 alkaline phosphatase, placental Homo sapiens 4-7 28326703-6 2016 The ALP activity and OCN mRNA expression levels of hPDLCs were both significantly improved (P<0.05) under treatment with different Sal B concentrations (0.5, 1, and 5 mumol L-1) compared with those in OIM group. salvianolic acid B 134-139 bone gamma-carboxyglutamate protein Homo sapiens 21-24 27557491-4 2016 Specific inhibition of autophagy by 3-MA or shRNA targeting Atg5 rescued Sal B-induced cell death in vitro and in vivo, suggesting that Sal B-induced autophagy may play a pro-death role and contribute to the cell death of colorectal cancer cell lines. salvianolic acid B 73-78 autophagy related 5 Homo sapiens 60-64 27557491-4 2016 Specific inhibition of autophagy by 3-MA or shRNA targeting Atg5 rescued Sal B-induced cell death in vitro and in vivo, suggesting that Sal B-induced autophagy may play a pro-death role and contribute to the cell death of colorectal cancer cell lines. salvianolic acid B 136-141 autophagy related 5 Homo sapiens 60-64 27557491-5 2016 Furthermore, AKT/mTOR signaling pathway was demonstrated to be a critical mediator in regulating Sal B-induced cell death. salvianolic acid B 97-102 AKT serine/threonine kinase 1 Homo sapiens 13-16 27557491-5 2016 Furthermore, AKT/mTOR signaling pathway was demonstrated to be a critical mediator in regulating Sal B-induced cell death. salvianolic acid B 97-102 mechanistic target of rapamycin kinase Homo sapiens 17-21 27557491-6 2016 Overexpression of AKT by the transfection with AKT plasmid or pretreatment with insulin decreased Sal B-induced autophagy and cell death. salvianolic acid B 98-103 AKT serine/threonine kinase 1 Homo sapiens 18-21 27557491-6 2016 Overexpression of AKT by the transfection with AKT plasmid or pretreatment with insulin decreased Sal B-induced autophagy and cell death. salvianolic acid B 98-103 AKT serine/threonine kinase 1 Homo sapiens 47-50 27557491-7 2016 Inversely, inhibition of AKT by LY294002 treatment markedly enhanced Sal B-induced autophagy and cell death. salvianolic acid B 69-74 AKT serine/threonine kinase 1 Homo sapiens 25-28 27557491-8 2016 Taken together, our results demonstrate, for the first time, that Sal B is a novel autophagy inducer and exerts its antitumor activity as a single agent in colorectal cancer cells through the suppression of AKT/mTOR pathway. salvianolic acid B 66-71 AKT serine/threonine kinase 1 Homo sapiens 207-210 27557491-8 2016 Taken together, our results demonstrate, for the first time, that Sal B is a novel autophagy inducer and exerts its antitumor activity as a single agent in colorectal cancer cells through the suppression of AKT/mTOR pathway. salvianolic acid B 66-71 mechanistic target of rapamycin kinase Homo sapiens 211-215 27497919-0 2016 Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 0-18 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 118-128 27497919-0 2016 Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 129-133 27497919-0 2016 Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 0-18 microRNA 200b Rattus norvegicus 138-146 27497919-0 2016 Salvianolic acid B improves the disruption of high glucose-mediated brain microvascular endothelial cells via the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 0-18 vascular endothelial growth factor A Rattus norvegicus 147-151 27497919-3 2016 And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B. salvianolic acid B 229-234 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 85-117 27497919-3 2016 And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B. salvianolic acid B 229-234 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 119-129 27497919-3 2016 And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B. salvianolic acid B 229-234 vascular endothelial growth factor A Rattus norvegicus 135-169 27497919-3 2016 And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B. salvianolic acid B 229-234 vascular endothelial growth factor A Rattus norvegicus 171-175 27497919-4 2016 In addition, a great decrease of microRNA-200b (miR-200b) was observed in the RBMECs under high-glucose condition, which was significantly increased by Sal B pretreatment. salvianolic acid B 152-157 microRNA 200b Rattus norvegicus 33-46 27497919-4 2016 In addition, a great decrease of microRNA-200b (miR-200b) was observed in the RBMECs under high-glucose condition, which was significantly increased by Sal B pretreatment. salvianolic acid B 152-157 microRNA 200b Rattus norvegicus 48-56 27497919-6 2016 This led to the conclusion that Sal B-mediated improvement of blood-brain barrier dysfunction induced by high-glucose is related to the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 32-37 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 140-150 27497919-6 2016 This led to the conclusion that Sal B-mediated improvement of blood-brain barrier dysfunction induced by high-glucose is related to the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 32-37 vascular endothelial growth factor A Rattus norvegicus 151-155 27497919-6 2016 This led to the conclusion that Sal B-mediated improvement of blood-brain barrier dysfunction induced by high-glucose is related to the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 32-37 microRNA 200b Rattus norvegicus 160-168 27497919-6 2016 This led to the conclusion that Sal B-mediated improvement of blood-brain barrier dysfunction induced by high-glucose is related to the ROS/HIF-1alpha/VEGF and miR-200b/VEGF signaling pathways. salvianolic acid B 32-37 vascular endothelial growth factor A Rattus norvegicus 169-173 27569393-9 2016 Co-exposure to Sal B (2 mumol/L) significantly attenuated deleterious alterations in bony tissue and oxidative stress in both Dex-treated AB zebafish larvae and tg (sp7:egfp) zebrafish larvae. salvianolic acid B 15-20 Sp7 transcription factor Danio rerio 165-168 27586425-0 2016 Salvianolic acid B induced upregulation of miR-30a protects cardiac myocytes from ischemia/reperfusion injury. salvianolic acid B 0-18 microRNA 30a Homo sapiens 43-50 27586425-8 2016 Knockdown of miR-30a with a miR-30a inhibitor could reverse the anti-autophagy effect of Sal B against I-R injury. salvianolic acid B 89-94 microRNA 30a Homo sapiens 28-35 27586425-2 2016 This study was designed to ascertain if miR-30a is involved in the cardioprotective actions of salvianolic acid B (Sal B) against myocardial ischemia-reperfusion (I-R) injury through suppression of autophagy. salvianolic acid B 95-113 microRNA 30a Homo sapiens 40-47 27586425-9 2016 Furthermore, we confirmed that Sal B has a protective role in miR-30a-mediated autophagy through the PI3K/Akt signaling pathway, which was abrogated by the PI3K inhibitor LY294002. salvianolic acid B 31-36 microRNA 30a Homo sapiens 62-69 27586425-2 2016 This study was designed to ascertain if miR-30a is involved in the cardioprotective actions of salvianolic acid B (Sal B) against myocardial ischemia-reperfusion (I-R) injury through suppression of autophagy. salvianolic acid B 115-120 microRNA 30a Homo sapiens 40-47 27586425-10 2016 CONCLUSIONS: These data suggest that miR-30a is involved in Sal B-mediated cardioprotection against I-R injury through the PI3K/Akt signaling pathway. salvianolic acid B 60-65 microRNA 30a Homo sapiens 37-44 27586425-5 2016 RESULTS: miR-30a expression was down-regulated remarkably in I-R cells, and this suppression could be reversed by Sal B in a dose-dependent manner. salvianolic acid B 114-119 microRNA 30a Homo sapiens 9-16 27586425-8 2016 Knockdown of miR-30a with a miR-30a inhibitor could reverse the anti-autophagy effect of Sal B against I-R injury. salvianolic acid B 89-94 microRNA 30a Homo sapiens 13-20 28852731-7 2016 RESULTS: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. salvianolic acid B 9-14 tumor necrosis factor Rattus norvegicus 118-127 30204390-9 2016 Pre-incubation with Sal B led to a significant enhancement of antioxidant capacity and a reduction of NOX4 protein expression, accompanied by a remarkable decrease of intracellular ROS and MDA content (P < 0.05 or P < 0.01). salvianolic acid B 20-25 NADPH oxidase 4 Homo sapiens 102-106 30204390-10 2016 Conclusion: Sal B is capable of suppressing IHG-induced injury and apoptosis in HUVECs, which might be attributed to the attenuation of oxidative stress, regulation of BCL-2/BAX protein expression, and subsequent suppression of Caspase-3 activity. salvianolic acid B 12-17 BCL2 apoptosis regulator Homo sapiens 168-173 30204390-10 2016 Conclusion: Sal B is capable of suppressing IHG-induced injury and apoptosis in HUVECs, which might be attributed to the attenuation of oxidative stress, regulation of BCL-2/BAX protein expression, and subsequent suppression of Caspase-3 activity. salvianolic acid B 12-17 BCL2 associated X, apoptosis regulator Homo sapiens 174-177 30204390-10 2016 Conclusion: Sal B is capable of suppressing IHG-induced injury and apoptosis in HUVECs, which might be attributed to the attenuation of oxidative stress, regulation of BCL-2/BAX protein expression, and subsequent suppression of Caspase-3 activity. salvianolic acid B 12-17 caspase 3 Homo sapiens 228-237 27513569-0 2016 Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenyls-induced oxidative stress through Nrf2. salvianolic acid B 36-54 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 27513569-6 2016 Taken together, as the Nrf2 regulates the cyto-protective response by up-regulating the expression of antioxidant genes, we suggested that CGA plus Sal B had a combined protection on PCB126-induced tissue damages and that the Nrf2 signaling might be involved. salvianolic acid B 148-153 nuclear factor, erythroid derived 2, like 2 Mus musculus 23-27 28852731-7 2016 RESULTS: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. salvianolic acid B 9-14 BCL2 associated X, apoptosis regulator Rattus norvegicus 281-284 28852731-7 2016 RESULTS: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. salvianolic acid B 9-14 caspase 3 Rattus norvegicus 289-298 28852731-7 2016 RESULTS: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. salvianolic acid B 9-14 BCL2, apoptosis regulator Rattus norvegicus 333-338 28852731-7 2016 RESULTS: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. salvianolic acid B 9-14 BCL2, apoptosis regulator Rattus norvegicus 373-378 28852731-7 2016 RESULTS: Sal B significantly improved heart function and decreased infarct size; remarkably decreased levels of serum TNF-alpha and IL-Iotabeta levels, increased contents of myocardium antioxidant enzymes activities; western blot results showed that Sal B ameliorate the increased Bax and caspase-3 protins expressions and decreased Bcl-2 proteins expression and ratios of Bcl-2 to Bax. salvianolic acid B 9-14 BCL2 associated X, apoptosis regulator Rattus norvegicus 382-385 27139338-9 2016 Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF. salvianolic acid B 0-5 BCL2 associated X, apoptosis regulator Rattus norvegicus 34-37 27139338-9 2016 Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF. salvianolic acid B 0-5 caspase 9 Rattus norvegicus 47-56 27139338-9 2016 Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF. salvianolic acid B 0-5 BCL2, apoptosis regulator Rattus norvegicus 108-113 27139338-9 2016 Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF. salvianolic acid B 0-5 beclin 1 Rattus norvegicus 123-130 27139338-9 2016 Sal B inhibited the expression of Bax, cleaved caspase-9 and cleaved PARP, while promoted the expression of Bcl-2, LC3-II, Beclin1 and VEGF. salvianolic acid B 0-5 vascular endothelial growth factor A Rattus norvegicus 135-139 27258307-0 2016 Salvianolic Acid B Inhibits Abeta Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells. salvianolic acid B 0-18 amyloid beta precursor protein Homo sapiens 28-33 30090438-8 2016 Further study indicated that Sal B protected against DOX induced cardiotoxicity, at least, partially, by inhibiting endoplasmic reticulum stress, and by being involved in the PI3K/Akt pathway. salvianolic acid B 29-34 thymoma viral proto-oncogene 1 Mus musculus 180-183 27258307-3 2016 Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Abeta-induced memory impairment. salvianolic acid B 32-50 amyloid beta precursor protein Homo sapiens 75-80 27258307-3 2016 Previous studies indicated that Salvianolic acid B (SalB) could ameliorate Abeta-induced memory impairment. salvianolic acid B 52-56 amyloid beta precursor protein Homo sapiens 75-80 27258307-9 2016 Our study suggests that SalB is a promising therapeutic agent for AD by targeting Abeta generation. salvianolic acid B 24-28 amyloid beta precursor protein Homo sapiens 82-87 27258307-0 2016 Salvianolic Acid B Inhibits Abeta Generation by Modulating BACE1 Activity in SH-SY5Y-APPsw Cells. salvianolic acid B 0-18 beta-secretase 1 Homo sapiens 59-64 27127491-5 2016 The amount of myelin sheath and the number of regenerating axons increased, neurological function recovered, and caspase-3 expression was decreased in the spinal cord of salvianolic acid B-treated animals compared with untreated control rats. salvianolic acid B 170-188 caspase 3 Rattus norvegicus 113-122 26777627-0 2016 Salvianolic acid B ameliorates CNS autoimmunity by suppressing Th1 responses. salvianolic acid B 0-18 negative elongation factor complex member C/D, Th1l Mus musculus 63-66 26777627-6 2016 Additionally, Sal B treatment downgraded the infiltration of inflammatory cells, limited astrogliosis and blocked Th1 responses other than that of Th17. salvianolic acid B 14-19 negative elongation factor complex member C/D, Th1l Mus musculus 114-117 26777627-7 2016 These results indicated that Sal B may serve as an effective therapeutic agent for MS/EAE by inhibiting Th1 cell responses. salvianolic acid B 29-34 negative elongation factor complex member C/D, Th1l Mus musculus 104-107 27941340-7 2016 Sal B treatment resulted in increased phosphorylated AMP-activated protein kinase (p-AMPK) protein expression in skeletal muscle and liver, increased glucose transporter 4 (GLUT4) and glycogen synthase protein expressions in skeletal muscle, and increased peroxisome proliferator-activated receptor alpha (PPARalpha) and phosphorylated acetyl CoA carboxylase (p-ACC) protein expressions in liver. salvianolic acid B 0-5 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 150-171 26637809-6 2016 Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1). salvianolic acid B 15-20 Wnt family member 2 Rattus norvegicus 59-62 26637809-6 2016 Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1). salvianolic acid B 15-20 catenin beta 1 Rattus norvegicus 63-75 26637809-6 2016 Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1). salvianolic acid B 15-20 catenin beta 1 Rattus norvegicus 107-119 26637809-6 2016 Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1). salvianolic acid B 15-20 Wnt inhibitory factor 1 Rattus norvegicus 124-147 26637809-6 2016 Interestingly, Sal B treatment induced the inactivation of Wnt/beta-catenin pathway, with an increase in P-beta-catenin and Wnt inhibitory factor 1 (WIF1). salvianolic acid B 15-20 Wnt inhibitory factor 1 Rattus norvegicus 149-153 26637809-7 2016 We demonstrated that the anti-fibrotic effects caused by Sal B were, at least in part, via WIF1. salvianolic acid B 57-62 Wnt inhibitory factor 1 Rattus norvegicus 91-95 27941340-7 2016 Sal B treatment resulted in increased phosphorylated AMP-activated protein kinase (p-AMPK) protein expression in skeletal muscle and liver, increased glucose transporter 4 (GLUT4) and glycogen synthase protein expressions in skeletal muscle, and increased peroxisome proliferator-activated receptor alpha (PPARalpha) and phosphorylated acetyl CoA carboxylase (p-ACC) protein expressions in liver. salvianolic acid B 0-5 peroxisome proliferator activated receptor alpha Mus musculus 256-304 27941340-7 2016 Sal B treatment resulted in increased phosphorylated AMP-activated protein kinase (p-AMPK) protein expression in skeletal muscle and liver, increased glucose transporter 4 (GLUT4) and glycogen synthase protein expressions in skeletal muscle, and increased peroxisome proliferator-activated receptor alpha (PPARalpha) and phosphorylated acetyl CoA carboxylase (p-ACC) protein expressions in liver. salvianolic acid B 0-5 peroxisome proliferator activated receptor alpha Mus musculus 306-315 27941340-7 2016 Sal B treatment resulted in increased phosphorylated AMP-activated protein kinase (p-AMPK) protein expression in skeletal muscle and liver, increased glucose transporter 4 (GLUT4) and glycogen synthase protein expressions in skeletal muscle, and increased peroxisome proliferator-activated receptor alpha (PPARalpha) and phosphorylated acetyl CoA carboxylase (p-ACC) protein expressions in liver. salvianolic acid B 0-5 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 173-178 29787004-1 2016 OBJECTIVE: To explore the influence of salvianolic acid B (Sal B) on cell proliferation and apoptosis of ovarian cancer cell line SKOV3, livin, and caspase-3 gene expression. salvianolic acid B 39-57 caspase 3 Homo sapiens 148-157 29787004-10 2016 Sal B had some inhibitory effects on livin expression in SKOV3 cell but promoted the expression of caspase-3. salvianolic acid B 0-5 baculoviral IAP repeat containing 7 Homo sapiens 37-42 29787004-10 2016 Sal B had some inhibitory effects on livin expression in SKOV3 cell but promoted the expression of caspase-3. salvianolic acid B 0-5 caspase 3 Homo sapiens 99-108 29787004-12 2016 CONCLUSIONS: Sal B has obvious effects on inhibiting growth and promoting apoptosis of ovarian cancer SKOV3 cell, which may be realized by downregulating livin expression, upregulating caspase-3 expression, and blocking the cell cycle. salvianolic acid B 13-18 baculoviral IAP repeat containing 7 Homo sapiens 154-159 29787004-12 2016 CONCLUSIONS: Sal B has obvious effects on inhibiting growth and promoting apoptosis of ovarian cancer SKOV3 cell, which may be realized by downregulating livin expression, upregulating caspase-3 expression, and blocking the cell cycle. salvianolic acid B 13-18 caspase 3 Homo sapiens 185-194 26523510-10 2015 Salvianolic acid B (SalB), a natural anti-oxidant, was detected by AFM to protect TGF-beta1-stimulated A549 cells against stiffening. salvianolic acid B 0-18 transforming growth factor, beta 1 Rattus norvegicus 82-91 27382429-0 2016 Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 27382429-0 2016 Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway. salvianolic acid B 0-18 NFE2 like bZIP transcription factor 2 Rattus norvegicus 105-109 27382429-6 2016 Compared with saline, intravenous SB pretreatment significantly attenuated elevations in serum creatinine and the histological changes of renal tubular injuries, reduced the number of apoptosis-positive tubular cells, activated Nrf2, and lowered the levels of renal oxidative stress induced by iodinated contrast media. salvianolic acid B 34-36 NFE2 like bZIP transcription factor 2 Rattus norvegicus 228-232 27382429-10 2016 Thus, our results demonstrate that, due to its antioxidant properties, SB has the potential to effectively prevent CI-AKI via the PI3K/Akt/Nrf2 pathway. salvianolic acid B 71-73 AKT serine/threonine kinase 1 Rattus norvegicus 135-138 27382429-10 2016 Thus, our results demonstrate that, due to its antioxidant properties, SB has the potential to effectively prevent CI-AKI via the PI3K/Akt/Nrf2 pathway. salvianolic acid B 71-73 NFE2 like bZIP transcription factor 2 Rattus norvegicus 139-143 26523510-10 2015 Salvianolic acid B (SalB), a natural anti-oxidant, was detected by AFM to protect TGF-beta1-stimulated A549 cells against stiffening. salvianolic acid B 20-24 transforming growth factor, beta 1 Rattus norvegicus 82-91 26525891-0 2015 Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease. salvianolic acid B 32-50 high mobility group box 1 Rattus norvegicus 14-19 26525891-0 2015 Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease. salvianolic acid B 32-50 sirtuin 1 Rattus norvegicus 60-65 26525891-5 2015 Importantly, SalB significantly inhibited HMGB1 nuclear translocation and release, accompanied by SIRT1 elevation. salvianolic acid B 13-17 high mobility group box 1 Rattus norvegicus 42-47 26525891-5 2015 Importantly, SalB significantly inhibited HMGB1 nuclear translocation and release, accompanied by SIRT1 elevation. salvianolic acid B 13-17 sirtuin 1 Rattus norvegicus 98-103 26525891-7 2015 Moreover, pharmacological SIRT1 inhibition by Ex527 induced HMGB1 translocation and release, whereas SIRT1 activation by resveratrol or SalB reversed this trend. salvianolic acid B 136-140 sirtuin 1 Rattus norvegicus 101-106 26257392-0 2015 Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation. salvianolic acid B 0-18 DNA methyltransferase (cytosine-5) 1 Mus musculus 79-84 26257392-0 2015 Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation. salvianolic acid B 0-18 patched 1 Mus musculus 94-102 26257392-6 2015 In this study, Salvianolic acid B (Sal B) suppressed the activation of HSCs in CCl4 -treated mice and mouse primary HSCs, leading to inhibition of cell proliferation, type I collagen and alpha-smooth muscle actin. salvianolic acid B 15-33 chemokine (C-C motif) ligand 4 Mus musculus 79-83 26257392-6 2015 In this study, Salvianolic acid B (Sal B) suppressed the activation of HSCs in CCl4 -treated mice and mouse primary HSCs, leading to inhibition of cell proliferation, type I collagen and alpha-smooth muscle actin. salvianolic acid B 35-40 chemokine (C-C motif) ligand 4 Mus musculus 79-83 26257392-8 2015 In particular, up-regulation of PTCH1 was associated with decreased DNA methylation level after Sal B treatment. salvianolic acid B 96-101 patched 1 Mus musculus 32-37 26257392-9 2015 Accordingly, DNA methyltransferase 1 (DNMT1) was attenuated by Sal B in vivo and in vitro. salvianolic acid B 63-68 DNA methyltransferase (cytosine-5) 1 Mus musculus 13-36 26257392-9 2015 Accordingly, DNA methyltransferase 1 (DNMT1) was attenuated by Sal B in vivo and in vitro. salvianolic acid B 63-68 DNA methyltransferase (cytosine-5) 1 Mus musculus 38-43 26257392-10 2015 The knockdown of DNMT1 in Sal B-treated HSCs enhanced PTCH1 expression and its demethylation level. salvianolic acid B 26-31 DNA methyltransferase (cytosine-5) 1 Mus musculus 17-22 26257392-10 2015 The knockdown of DNMT1 in Sal B-treated HSCs enhanced PTCH1 expression and its demethylation level. salvianolic acid B 26-31 patched 1 Mus musculus 54-59 26257392-13 2015 Further studies showed that the miR-152 inhibitor reversed Sal B-mediated PTCH1 up-regulation and DNMT1 down-regulation. salvianolic acid B 59-64 microRNA 152 Mus musculus 32-39 26257392-13 2015 Further studies showed that the miR-152 inhibitor reversed Sal B-mediated PTCH1 up-regulation and DNMT1 down-regulation. salvianolic acid B 59-64 patched 1 Mus musculus 74-79 26257392-14 2015 Collectively, miR-152 induced by Sal B, contributed to DNMT1 down-regulation and epigenetically regulated PTCH1, resulting in the inhibition of EMT in liver fibrosis. salvianolic acid B 33-38 microRNA 152 Mus musculus 14-21 26257392-14 2015 Collectively, miR-152 induced by Sal B, contributed to DNMT1 down-regulation and epigenetically regulated PTCH1, resulting in the inhibition of EMT in liver fibrosis. salvianolic acid B 33-38 DNA methyltransferase (cytosine-5) 1 Mus musculus 55-60 26257392-14 2015 Collectively, miR-152 induced by Sal B, contributed to DNMT1 down-regulation and epigenetically regulated PTCH1, resulting in the inhibition of EMT in liver fibrosis. salvianolic acid B 33-38 patched 1 Mus musculus 106-111 25956064-3 2015 Here, we sought to investigate the effects of Sal B on the cholesterol efflux in THP-1 macrophages. salvianolic acid B 46-51 GLI family zinc finger 2 Homo sapiens 81-86 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 tumor necrosis factor Mus musculus 118-145 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 tumor necrosis factor Mus musculus 147-156 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 interleukin 6 Mus musculus 159-172 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 interleukin 6 Mus musculus 174-178 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 interleukin 1 beta Mus musculus 181-198 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 interleukin 1 beta Mus musculus 200-208 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 chemokine (C-C motif) ligand 2 Mus musculus 215-249 25975489-7 2015 The results showed that Sal B inhibited CS-induced lung pathological changes, the infiltration of inflammatory cells, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1beta (IL-1beta), and monocyte chemoattractant protein 1 (MCP-1) productions. salvianolic acid B 24-29 chemokine (C-C motif) ligand 2 Mus musculus 251-256 25975489-9 2015 Furthermore, Sal B was found to up-regulate Nrf-2, hemeoxygenase1 (HO1) expression and suppress CS-induced NF-kappaB activation. salvianolic acid B 13-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 44-49 25975489-9 2015 Furthermore, Sal B was found to up-regulate Nrf-2, hemeoxygenase1 (HO1) expression and suppress CS-induced NF-kappaB activation. salvianolic acid B 13-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 107-116 25975489-10 2015 In conclusion, the current study demonstrated that Sal B exhibited a protective effect on CS-induced lung injury and the possible mechanism was involved in activating Nrf-2 and inhibiting NF-kappaB activation. salvianolic acid B 51-56 nuclear factor, erythroid derived 2, like 2 Mus musculus 167-172 25975489-10 2015 In conclusion, the current study demonstrated that Sal B exhibited a protective effect on CS-induced lung injury and the possible mechanism was involved in activating Nrf-2 and inhibiting NF-kappaB activation. salvianolic acid B 51-56 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 188-197 25892295-0 2015 Salvianolic acid B improves bone marrow-derived mesenchymal stem cell differentiation into alveolar epithelial cells type I via Wnt signaling. salvianolic acid B 0-18 Wnt family member 1 Homo sapiens 128-131 25892295-9 2015 It was revealed that aquaporin (AQP)-5 and T1alpha were expressed in BMSCs, and induction with LiCl or Sal B increased the expression of AQP-5 and T1alpha. salvianolic acid B 103-108 aquaporin 5 Homo sapiens 21-38 25892295-9 2015 It was revealed that aquaporin (AQP)-5 and T1alpha were expressed in BMSCs, and induction with LiCl or Sal B increased the expression of AQP-5 and T1alpha. salvianolic acid B 103-108 aquaporin 5 Homo sapiens 137-142 25892295-9 2015 It was revealed that aquaporin (AQP)-5 and T1alpha were expressed in BMSCs, and induction with LiCl or Sal B increased the expression of AQP-5 and T1alpha. salvianolic acid B 103-108 podoplanin Homo sapiens 147-154 25892295-11 2015 In conclusion, it was suggested that the promotive effects of Sal B on the differentiation of BMSCs into ATI occurred through the activation of Wnt signaling pathways. salvianolic acid B 62-67 Wnt family member 1 Homo sapiens 144-147 25956064-9 2015 Then the data demonstrated that Sal B increased the expression of PPAR-gamma and LXRalpha. salvianolic acid B 32-37 peroxisome proliferator activated receptor gamma Homo sapiens 66-76 25956064-9 2015 Then the data demonstrated that Sal B increased the expression of PPAR-gamma and LXRalpha. salvianolic acid B 32-37 nuclear receptor subfamily 1 group H member 3 Homo sapiens 81-89 25956064-11 2015 CONCLUSION: These results demonstrate that Sal B promotes cholesterol efflux in THP-1 macrophages through ABCA1/PPAR-gamma/LXRalpha pathway. salvianolic acid B 43-48 GLI family zinc finger 2 Homo sapiens 80-85 26415806-0 2015 Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-alpha-induced Human Coronary Artery Endothelial Cells. salvianolic acid B 0-18 matrix metallopeptidase 9 Homo sapiens 34-60 26415806-0 2015 Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-alpha-induced Human Coronary Artery Endothelial Cells. salvianolic acid B 0-18 tumor necrosis factor Homo sapiens 88-115 26415806-2 2015 This study sought to evaluate the effect of Sal B on matrix metalloproteinase-9 (MMP-9) and on the underlying mechanisms in tumor necrosis factor-alpha+- (TNF-alpha+-)-activated human coronary artery endothelial cells (HCAECs), a cell model of Kawasaki disease. salvianolic acid B 44-49 matrix metallopeptidase 9 Homo sapiens 53-79 26415806-2 2015 This study sought to evaluate the effect of Sal B on matrix metalloproteinase-9 (MMP-9) and on the underlying mechanisms in tumor necrosis factor-alpha+- (TNF-alpha+-)-activated human coronary artery endothelial cells (HCAECs), a cell model of Kawasaki disease. salvianolic acid B 44-49 matrix metallopeptidase 9 Homo sapiens 81-86 26415806-2 2015 This study sought to evaluate the effect of Sal B on matrix metalloproteinase-9 (MMP-9) and on the underlying mechanisms in tumor necrosis factor-alpha+- (TNF-alpha+-)-activated human coronary artery endothelial cells (HCAECs), a cell model of Kawasaki disease. salvianolic acid B 44-49 tumor necrosis factor Homo sapiens 155-164 26415806-7 2015 RESULTS: After HCAECs were exposed to TNF-alpha+-, 1-10 alphamumol/L Sal B significantly inhibited TNF-alpha+--induced MMP-9 expression and activity. salvianolic acid B 69-74 tumor necrosis factor Homo sapiens 38-47 26415806-7 2015 RESULTS: After HCAECs were exposed to TNF-alpha+-, 1-10 alphamumol/L Sal B significantly inhibited TNF-alpha+--induced MMP-9 expression and activity. salvianolic acid B 69-74 tumor necrosis factor Homo sapiens 99-108 26415806-7 2015 RESULTS: After HCAECs were exposed to TNF-alpha+-, 1-10 alphamumol/L Sal B significantly inhibited TNF-alpha+--induced MMP-9 expression and activity. salvianolic acid B 69-74 matrix metallopeptidase 9 Homo sapiens 119-124 26415806-10 2015 CONCLUSIONS: The data suggested that Sal B suppressed TNF-alpha+--induced MMP-9 expression and activity by blocking the activation of NF-kappaB, JNK, and ERK1/2 signaling pathways. salvianolic acid B 37-42 tumor necrosis factor Homo sapiens 54-63 26415806-10 2015 CONCLUSIONS: The data suggested that Sal B suppressed TNF-alpha+--induced MMP-9 expression and activity by blocking the activation of NF-kappaB, JNK, and ERK1/2 signaling pathways. salvianolic acid B 37-42 matrix metallopeptidase 9 Homo sapiens 74-79 26415806-10 2015 CONCLUSIONS: The data suggested that Sal B suppressed TNF-alpha+--induced MMP-9 expression and activity by blocking the activation of NF-kappaB, JNK, and ERK1/2 signaling pathways. salvianolic acid B 37-42 mitogen-activated protein kinase 8 Homo sapiens 145-148 26415806-10 2015 CONCLUSIONS: The data suggested that Sal B suppressed TNF-alpha+--induced MMP-9 expression and activity by blocking the activation of NF-kappaB, JNK, and ERK1/2 signaling pathways. salvianolic acid B 37-42 mitogen-activated protein kinase 3 Homo sapiens 154-160 25956064-11 2015 CONCLUSION: These results demonstrate that Sal B promotes cholesterol efflux in THP-1 macrophages through ABCA1/PPAR-gamma/LXRalpha pathway. salvianolic acid B 43-48 ATP binding cassette subfamily A member 1 Homo sapiens 106-111 25956064-11 2015 CONCLUSION: These results demonstrate that Sal B promotes cholesterol efflux in THP-1 macrophages through ABCA1/PPAR-gamma/LXRalpha pathway. salvianolic acid B 43-48 peroxisome proliferator activated receptor gamma Homo sapiens 112-122 25956064-11 2015 CONCLUSION: These results demonstrate that Sal B promotes cholesterol efflux in THP-1 macrophages through ABCA1/PPAR-gamma/LXRalpha pathway. salvianolic acid B 43-48 nuclear receptor subfamily 1 group H member 3 Homo sapiens 123-131 25956064-5 2015 The expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and liver X receptor-alpha (LXRalpha) was detected both at protein and mRNA levels in THP-1 cells after the stimulation of Sal B. salvianolic acid B 249-254 ATP binding cassette subfamily A member 1 Homo sapiens 18-53 25956064-5 2015 The expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and liver X receptor-alpha (LXRalpha) was detected both at protein and mRNA levels in THP-1 cells after the stimulation of Sal B. salvianolic acid B 249-254 peroxisome proliferator activated receptor gamma Homo sapiens 63-111 25956064-5 2015 The expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and liver X receptor-alpha (LXRalpha) was detected both at protein and mRNA levels in THP-1 cells after the stimulation of Sal B. salvianolic acid B 249-254 peroxisome proliferator activated receptor gamma Homo sapiens 113-123 25956064-5 2015 The expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and liver X receptor-alpha (LXRalpha) was detected both at protein and mRNA levels in THP-1 cells after the stimulation of Sal B. salvianolic acid B 249-254 nuclear receptor subfamily 1 group H member 3 Homo sapiens 154-162 25956064-5 2015 The expression of ATP binding cassette transporter A1 (ABCA1), peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and liver X receptor-alpha (LXRalpha) was detected both at protein and mRNA levels in THP-1 cells after the stimulation of Sal B. salvianolic acid B 249-254 GLI family zinc finger 2 Homo sapiens 212-217 25956064-7 2015 RESULTS: The results showed that Sal B significantly accelerated apoA-I- and HDL-mediated cholesterol efflux in both dose- and time-dependent manners. salvianolic acid B 33-38 apolipoprotein A1 Homo sapiens 65-71 25956064-8 2015 Meanwhile, Sal B treatment also enhanced the expression of ABCA1 at both mRNA and protein levels. salvianolic acid B 11-16 ATP binding cassette subfamily A member 1 Homo sapiens 59-64 25081897-0 2015 Antioxidant effect of salvianolic acid B on hippocampal CA1 neurons in mice with cerebral ischemia and reperfusion injury. salvianolic acid B 22-40 carbonic anhydrase 1 Mus musculus 56-59 25081897-1 2015 OBJETIVE: To investigate the neuroprotective effects and underlying mechanisms of salvianolic acid B (Sal B) extracted from Salvia miltiorrhiza on hippocampal CA1 neurons in mice with cerebral ischemia reperfusion injury. salvianolic acid B 82-100 carbonic anhydrase 1 Mus musculus 159-162 25081897-1 2015 OBJETIVE: To investigate the neuroprotective effects and underlying mechanisms of salvianolic acid B (Sal B) extracted from Salvia miltiorrhiza on hippocampal CA1 neurons in mice with cerebral ischemia reperfusion injury. salvianolic acid B 102-107 carbonic anhydrase 1 Mus musculus 159-162 25626519-0 2015 Salvianolic Acid B Protects Normal Human Dermal Fibroblasts Against Ultraviolet B Irradiation-Induced Photoaging Through Mitogen-Activated Protein Kinase and Activator Protein-1 Pathways. salvianolic acid B 0-18 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 158-177 25626519-4 2015 Our results show that SAB significantly inhibited the UVB-induced expression of metalloproteinases-1 (MMP-1) and interleukin-6 (IL-6) while promoting the production of type I procollagen and transforming growth factor beta1 (TGF-beta1). salvianolic acid B 22-25 matrix metallopeptidase 1 Homo sapiens 80-107 25626519-4 2015 Our results show that SAB significantly inhibited the UVB-induced expression of metalloproteinases-1 (MMP-1) and interleukin-6 (IL-6) while promoting the production of type I procollagen and transforming growth factor beta1 (TGF-beta1). salvianolic acid B 22-25 interleukin 6 Homo sapiens 113-126 25626519-4 2015 Our results show that SAB significantly inhibited the UVB-induced expression of metalloproteinases-1 (MMP-1) and interleukin-6 (IL-6) while promoting the production of type I procollagen and transforming growth factor beta1 (TGF-beta1). salvianolic acid B 22-25 interleukin 6 Homo sapiens 128-132 25626519-4 2015 Our results show that SAB significantly inhibited the UVB-induced expression of metalloproteinases-1 (MMP-1) and interleukin-6 (IL-6) while promoting the production of type I procollagen and transforming growth factor beta1 (TGF-beta1). salvianolic acid B 22-25 transforming growth factor beta 1 Homo sapiens 225-234 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 1 Homo sapiens 94-131 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 1 Homo sapiens 133-136 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 8 Homo sapiens 139-160 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 8 Homo sapiens 162-165 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 mitogen-activated protein kinase 1 Homo sapiens 171-174 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 252-257 25626519-5 2015 Moreover, treatment with SAB in the range of 1-100 mug/mL significantly inhibited UVB-induced extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 phosphorylation, which resulted in decreasing UVB-induced phosphorylation of c-Fos and c-Jun. salvianolic acid B 25-28 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 262-267 25626519-6 2015 These results indicate that SAB downregulates UV-induced MMP-1 expression by inhibiting Mitogen-activated protein kinase (MAPK) signaling pathways and activator protein-1 (AP-1) activation. salvianolic acid B 28-31 matrix metallopeptidase 1 Homo sapiens 57-62 25626519-6 2015 These results indicate that SAB downregulates UV-induced MMP-1 expression by inhibiting Mitogen-activated protein kinase (MAPK) signaling pathways and activator protein-1 (AP-1) activation. salvianolic acid B 28-31 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 151-170 25626519-6 2015 These results indicate that SAB downregulates UV-induced MMP-1 expression by inhibiting Mitogen-activated protein kinase (MAPK) signaling pathways and activator protein-1 (AP-1) activation. salvianolic acid B 28-31 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 172-176 25981395-0 2015 Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats. salvianolic acid B 0-18 sirtuin 1 Rattus norvegicus 61-66 25981395-11 2015 SalB also exerted anti-inflammatory effects as indicated by the decreased TNF-alpha and IL-1beta levels in the brain tissue. salvianolic acid B 0-4 tumor necrosis factor Rattus norvegicus 74-83 25981395-11 2015 SalB also exerted anti-inflammatory effects as indicated by the decreased TNF-alpha and IL-1beta levels in the brain tissue. salvianolic acid B 0-4 interleukin 1 beta Rattus norvegicus 88-96 25981395-14 2015 In summary, our results demonstrate that SalB treatment attenuates brain injury induced by ischemic stoke via reducing apoptosis and inflammation through the activation of SIRT1 signaling. salvianolic acid B 41-45 sirtuin 1 Rattus norvegicus 172-177 25992563-0 2015 Salvianolic Acid B Ameliorates Lipopolysaccharide-Induced Albumin Leakage from Rat Mesenteric Venules through Src-Regulated Transcelluar Pathway and Paracellular Pathway. salvianolic acid B 0-18 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 110-113 26191218-8 2015 RESULTS: Plasma levels of ALT, AST, TG, TC, ET and DAO were significantly higher in model group than those in both control group and group treated with Sal B. salvianolic acid B 152-157 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 31-34 26191218-11 2015 Immunohistochemical staining showed that Sal B administration recovered the expression of occludin and ZO-1, which was downregulated in the model group. salvianolic acid B 41-46 occludin Rattus norvegicus 90-98 26191218-11 2015 Immunohistochemical staining showed that Sal B administration recovered the expression of occludin and ZO-1, which was downregulated in the model group. salvianolic acid B 41-46 tight junction protein 1 Rattus norvegicus 103-107 25654620-10 2015 In particular, Sal-B inhibited HIF1alpha, BNIP3, and cleavage caspase 3 expression levels, thereby suppressing apoptosis. salvianolic acid B 15-20 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 31-40 25654620-10 2015 In particular, Sal-B inhibited HIF1alpha, BNIP3, and cleavage caspase 3 expression levels, thereby suppressing apoptosis. salvianolic acid B 15-20 BCL2 interacting protein 3 Rattus norvegicus 42-47 25654620-0 2015 Differentiation of embryonic stem cells into cardiomyocytes used to investigate the cardioprotective effect of salvianolic acid B through BNIP3 involved pathway. salvianolic acid B 111-129 BCL2 interacting protein 3 Rattus norvegicus 138-143 25654620-10 2015 In particular, Sal-B inhibited HIF1alpha, BNIP3, and cleavage caspase 3 expression levels, thereby suppressing apoptosis. salvianolic acid B 15-20 caspase 3 Rattus norvegicus 62-71 25654620-11 2015 This is the first study to mention the correlation between BNIP3 and Sal-B for cardioprotective effects. salvianolic acid B 69-74 BCL2 interacting protein 3 Rattus norvegicus 59-64 25094038-0 2014 Expression of miR-106b-25 induced by salvianolic acid B inhibits epithelial-to-mesenchymal transition in HK-2 cells. salvianolic acid B 37-55 microRNA 106b Homo sapiens 14-22 25094038-5 2014 After validation by real-time PCR, all three members of the miR-106b-25 cluster (miR-106b, miR-93, and miR-25) were found to be markedly down-regulated during EMT in response to TGF-beta1, whereas these miRNAs were up-regulated by Sal B treatment in a dose-dependent manner. salvianolic acid B 231-236 microRNA 106b Homo sapiens 81-89 25094038-5 2014 After validation by real-time PCR, all three members of the miR-106b-25 cluster (miR-106b, miR-93, and miR-25) were found to be markedly down-regulated during EMT in response to TGF-beta1, whereas these miRNAs were up-regulated by Sal B treatment in a dose-dependent manner. salvianolic acid B 231-236 microRNA 106b Homo sapiens 60-68 25094038-5 2014 After validation by real-time PCR, all three members of the miR-106b-25 cluster (miR-106b, miR-93, and miR-25) were found to be markedly down-regulated during EMT in response to TGF-beta1, whereas these miRNAs were up-regulated by Sal B treatment in a dose-dependent manner. salvianolic acid B 231-236 microRNA 9-3 Homo sapiens 91-97 25077998-0 2014 Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: evidence from clinic to laboratory. salvianolic acid B 0-18 purinergic receptor P2Y12 Homo sapiens 43-48 25094038-5 2014 After validation by real-time PCR, all three members of the miR-106b-25 cluster (miR-106b, miR-93, and miR-25) were found to be markedly down-regulated during EMT in response to TGF-beta1, whereas these miRNAs were up-regulated by Sal B treatment in a dose-dependent manner. salvianolic acid B 231-236 microRNA 25 Homo sapiens 103-109 25094038-5 2014 After validation by real-time PCR, all three members of the miR-106b-25 cluster (miR-106b, miR-93, and miR-25) were found to be markedly down-regulated during EMT in response to TGF-beta1, whereas these miRNAs were up-regulated by Sal B treatment in a dose-dependent manner. salvianolic acid B 231-236 transforming growth factor beta 1 Homo sapiens 178-187 25094038-9 2014 In conclusion, our data suggest that the miR-106b-25 cluster may contribute to EMT in the kidney, and is involved in the protective effect of Sal B. salvianolic acid B 142-147 microRNA 106b Homo sapiens 41-49 25294002-12 2014 The expression of VEGF and inflammatory factors in operative sites also suggested better results in the Sal B group than the other two groups. salvianolic acid B 104-109 vascular endothelial growth factor A Rattus norvegicus 18-22 24991814-0 2014 Salvianolic acid B attenuates toxin-induced neuronal damage via Nrf2-dependent glial cells-mediated protective activity in Parkinson"s disease models. salvianolic acid B 0-18 nuclear factor, erythroid derived 2, like 2 Mus musculus 64-68 24723056-10 2014 Our results showed that cTnT expression in 5-aza + salB + CLM group was ninefold higher than in the control group in the non-beta-catenin MSCs model, implying that cardiomyocytes differentiation from MSCs is an extremely complicated process and it is necessary to consider the internal and external environmental conditions, such as suitable pharmaceutical inducers, cardiomyocytes microenvironments, inhibition of the negative signaling pathway and so on. salvianolic acid B 51-55 troponin T2, cardiac type Homo sapiens 24-28 24769256-4 2014 The results showed that pretreatment with SalB significantly reduced ethanol-induced elevation in aminotransferase activities, decreased hepatotoxic cytokine levels such as Interleukin-6 (IL-6), and increased the antioxidant enzyme activity. salvianolic acid B 42-46 interleukin 6 Rattus norvegicus 173-186 24769256-4 2014 The results showed that pretreatment with SalB significantly reduced ethanol-induced elevation in aminotransferase activities, decreased hepatotoxic cytokine levels such as Interleukin-6 (IL-6), and increased the antioxidant enzyme activity. salvianolic acid B 42-46 interleukin 6 Rattus norvegicus 188-192 24769256-5 2014 Moreover, SalB pretreatment reversed the increase in NF-kappaB, cleaved caspase-3 and decrease in B-cell lymphoma-extra large (Bcl-xL) caused by ethanol exposure. salvianolic acid B 10-14 Bcl2-like 1 Rattus norvegicus 127-133 24991814-5 2014 Additionally, SalB treatment inhibited the release of microglial pro-inflammatory cytokines and resulted in an increase in the expression and release of glial cell line-derived neurotrophic factor (GDNF) from astrocytes. salvianolic acid B 14-18 glial cell line derived neurotrophic factor Mus musculus 153-196 24991814-5 2014 Additionally, SalB treatment inhibited the release of microglial pro-inflammatory cytokines and resulted in an increase in the expression and release of glial cell line-derived neurotrophic factor (GDNF) from astrocytes. salvianolic acid B 14-18 glial cell line derived neurotrophic factor Mus musculus 198-202 24991814-7 2014 The knockdown of Nrf2 using specific small interfering RNA (siRNA) partially reversed the SalB-induced GDNF expression and anti-inflammatory activity. salvianolic acid B 90-94 nuclear factor, erythroid derived 2, like 2 Mus musculus 17-21 24991814-7 2014 The knockdown of Nrf2 using specific small interfering RNA (siRNA) partially reversed the SalB-induced GDNF expression and anti-inflammatory activity. salvianolic acid B 90-94 glial cell line derived neurotrophic factor Mus musculus 103-107 24991814-8 2014 Moreover, SalB treatment significantly attenuated dopaminergic (DA) neuronal loss, inhibited neuroinflammation, increased GDNF expression and improved the neurological function in MPTP-treated mice. salvianolic acid B 10-14 glial cell line derived neurotrophic factor Mus musculus 122-126 24387840-0 2014 Salvianolic acid B attenuates spinal cord ischemia-reperfusion-induced neuronal injury and oxidative stress by activating the extracellular signal-regulated kinase pathway in rats. salvianolic acid B 0-18 Eph receptor B1 Rattus norvegicus 126-163 24739088-7 2014 The intravenous administration of 1, 3 or 6 mg/kg salvianolic acid B attenuated the increases in APTT, PT, BUN, ALT and plasma TNF-alpha and the decreases in fibrinogen, platelet, FDP, protein C and ATIII induced by LPS infusion. salvianolic acid B 50-68 tumor necrosis factor Oryctolagus cuniculus 127-136 24657587-5 2014 The results showed Salvianolic acid B (Sal B) had no obvious toxic effects on hMSCs, whereas Sal B supplementation (5muM) increased the alkaline phosphatase activity, osteopontin, Runx2 and osterix expression in hMSCs. salvianolic acid B 93-98 secreted phosphoprotein 1 Homo sapiens 167-178 24657587-5 2014 The results showed Salvianolic acid B (Sal B) had no obvious toxic effects on hMSCs, whereas Sal B supplementation (5muM) increased the alkaline phosphatase activity, osteopontin, Runx2 and osterix expression in hMSCs. salvianolic acid B 93-98 RUNX family transcription factor 2 Homo sapiens 180-185 24657587-5 2014 The results showed Salvianolic acid B (Sal B) had no obvious toxic effects on hMSCs, whereas Sal B supplementation (5muM) increased the alkaline phosphatase activity, osteopontin, Runx2 and osterix expression in hMSCs. salvianolic acid B 93-98 Sp7 transcription factor Homo sapiens 190-197 24780446-0 2014 Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. salvianolic acid B 0-18 AKT serine/threonine kinase 1 Homo sapiens 123-126 24780446-0 2014 Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. salvianolic acid B 0-18 mechanistic target of rapamycin kinase Homo sapiens 127-131 24780446-0 2014 Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. salvianolic acid B 0-18 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 132-137 24780446-0 2014 Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. salvianolic acid B 0-18 activating transcription factor 2 Homo sapiens 148-152 24780446-0 2014 Salvianolic acid B protects human endothelial progenitor cells against oxidative stress-mediated dysfunction by modulating Akt/mTOR/4EBP1, p38 MAPK/ATF2, and ERK1/2 signaling pathways. salvianolic acid B 0-18 mitogen-activated protein kinase 3 Homo sapiens 158-164 24387840-7 2014 Moreover, SalB prolonged the I/R injury-induced activation of extracellular signal-regulated kinase (ERK), and blocking ERK activation with PD98059 partially prevented the neuroprotective effects of SalB. salvianolic acid B 10-14 Eph receptor B1 Rattus norvegicus 62-99 24387840-7 2014 Moreover, SalB prolonged the I/R injury-induced activation of extracellular signal-regulated kinase (ERK), and blocking ERK activation with PD98059 partially prevented the neuroprotective effects of SalB. salvianolic acid B 10-14 Eph receptor B1 Rattus norvegicus 101-104 24387840-7 2014 Moreover, SalB prolonged the I/R injury-induced activation of extracellular signal-regulated kinase (ERK), and blocking ERK activation with PD98059 partially prevented the neuroprotective effects of SalB. salvianolic acid B 199-203 Eph receptor B1 Rattus norvegicus 120-123 24387840-8 2014 CONCLUSIONS: These findings demonstrate the neuroprotective effects of SalB in a spinal cord I/R injury model and suggest that SalB-induced neuroprotection was mediated by ERK activation. salvianolic acid B 127-131 Eph receptor B1 Rattus norvegicus 172-175 24934350-0 2014 Salvianolic acid B inhibits atherogenesis of vascular cells through induction of Nrf2-dependent heme oxygenase-1. salvianolic acid B 0-18 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 25173227-0 2014 [Effects of salvianolic acid B on endothelin-1-induced contraction and cytoskeleton organization of hepatic stellate cells in rats]. salvianolic acid B 12-30 endothelin 1 Rattus norvegicus 34-46 25173227-1 2014 OBJECTIVE: To investigate the effects of salvianolic acid B (Sal B) on endothelin-1 (ET1)-induced contraction and cytoskeleton reorganization of rat hepatic stellate cells (HSCs). salvianolic acid B 41-59 endothelin 1 Rattus norvegicus 71-83 25173227-1 2014 OBJECTIVE: To investigate the effects of salvianolic acid B (Sal B) on endothelin-1 (ET1)-induced contraction and cytoskeleton reorganization of rat hepatic stellate cells (HSCs). salvianolic acid B 41-59 endothelin 1 Rattus norvegicus 85-88 25173227-1 2014 OBJECTIVE: To investigate the effects of salvianolic acid B (Sal B) on endothelin-1 (ET1)-induced contraction and cytoskeleton reorganization of rat hepatic stellate cells (HSCs). salvianolic acid B 61-66 endothelin 1 Rattus norvegicus 71-83 25173227-1 2014 OBJECTIVE: To investigate the effects of salvianolic acid B (Sal B) on endothelin-1 (ET1)-induced contraction and cytoskeleton reorganization of rat hepatic stellate cells (HSCs). salvianolic acid B 61-66 endothelin 1 Rattus norvegicus 85-88 25173227-12 2014 The Sal B pretreatment led to a significant decrease in ET-1-induced MLC2 phosphorylation (by 63.1%) and an obvious disassembly of actin stress fibers. salvianolic acid B 4-9 endothelin 1 Rattus norvegicus 56-60 25173227-12 2014 The Sal B pretreatment led to a significant decrease in ET-1-induced MLC2 phosphorylation (by 63.1%) and an obvious disassembly of actin stress fibers. salvianolic acid B 4-9 myosin light chain 2 Rattus norvegicus 69-73 25173227-13 2014 CONCLUSION: Sal B effectively inhibits ET-1-induced rat HSC contraction, through its suppressive effects on MLC2 phosphorylation and promotion of the disassembly of actin stress fibers. salvianolic acid B 12-17 endothelin 1 Rattus norvegicus 39-43 25173227-13 2014 CONCLUSION: Sal B effectively inhibits ET-1-induced rat HSC contraction, through its suppressive effects on MLC2 phosphorylation and promotion of the disassembly of actin stress fibers. salvianolic acid B 12-17 myosin light chain 2 Rattus norvegicus 108-112 24374609-11 2014 The accumulative release percentage of TSN, GA and Sal B were 10% in 36 h, 4% in 36 h and 77% in 24 h. Meanwhile, GTS-lip exhibited definite activity on proliferative inhibition of hepatic stellate cells (HSC). salvianolic acid B 51-56 GTS Homo sapiens 114-117 24531218-1 2014 Danshensu (DSU) and salvianolic acid B (SAB) are the primary water-soluble compounds of Salvia miltiorrhiza Bunge (Lamiaceae). salvianolic acid B 20-38 SH3 domain binding protein 5 Homo sapiens 40-43 25034045-0 2014 Salvianolic acid B inhibited PPARgamma expression and attenuated weight gain in mice with high-fat diet-induced obesity. salvianolic acid B 0-18 peroxisome proliferator activated receptor gamma Mus musculus 29-38 25034045-11 2014 Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3) both in vivo and in vitro. salvianolic acid B 30-35 peroxisome proliferator activated receptor gamma Mus musculus 96-105 25034045-11 2014 Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3) both in vivo and in vitro. salvianolic acid B 30-35 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 111-147 25034045-11 2014 Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3) both in vivo and in vitro. salvianolic acid B 30-35 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 149-159 25034045-11 2014 Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3) both in vivo and in vitro. salvianolic acid B 30-35 GATA binding protein 2 Mus musculus 204-232 25034045-11 2014 Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3) both in vivo and in vitro. salvianolic acid B 30-35 GATA binding protein 2 Mus musculus 234-240 25034045-11 2014 Immunoblotting indicated that Sal B decreased peroxisome proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer binding protein alpha (C/EBPalpha) expression but increased the expression of GATA binding protein 2 and 3 (GATA 2, GATA 3) both in vivo and in vitro. salvianolic acid B 30-35 GATA binding protein 3 Mus musculus 242-248 25034045-13 2014 The effects of Sal B in adipose tissue may be related to its action on PPARgamma, C/EBPalpha, GATA-2 and GATA-3. salvianolic acid B 15-20 peroxisome proliferator activated receptor gamma Mus musculus 71-80 25034045-13 2014 The effects of Sal B in adipose tissue may be related to its action on PPARgamma, C/EBPalpha, GATA-2 and GATA-3. salvianolic acid B 15-20 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 82-92 25034045-13 2014 The effects of Sal B in adipose tissue may be related to its action on PPARgamma, C/EBPalpha, GATA-2 and GATA-3. salvianolic acid B 15-20 GATA binding protein 2 Mus musculus 94-100 25034045-13 2014 The effects of Sal B in adipose tissue may be related to its action on PPARgamma, C/EBPalpha, GATA-2 and GATA-3. salvianolic acid B 15-20 GATA binding protein 3 Mus musculus 105-111 24669910-0 2014 The inhibitory effect of salvianolic acid B on TGF-beta1-induced proliferation and differentiation in lung fibroblasts. salvianolic acid B 25-43 transforming growth factor beta 1 Homo sapiens 47-56 24669910-9 2014 Interestingly, Sal B was found to inhibit TGF-beta1-induced cell proliferation, expression of type I collagen, endogenous TGF-beta1 production, and alpha-SMA expression in lung fibroblasts. salvianolic acid B 15-20 transforming growth factor beta 1 Homo sapiens 42-51 24669910-9 2014 Interestingly, Sal B was found to inhibit TGF-beta1-induced cell proliferation, expression of type I collagen, endogenous TGF-beta1 production, and alpha-SMA expression in lung fibroblasts. salvianolic acid B 15-20 transforming growth factor beta 1 Homo sapiens 122-131 24669910-10 2014 Moreover, the inhibitory effect of Sal B on TGF-beta1-induced proliferation and differentiation in lung fibroblasts was more significant when treated with high-dose Sal B (1 mumol/L versus 10 mumol/L, P < .05). salvianolic acid B 35-40 transforming growth factor beta 1 Homo sapiens 44-53 24669910-10 2014 Moreover, the inhibitory effect of Sal B on TGF-beta1-induced proliferation and differentiation in lung fibroblasts was more significant when treated with high-dose Sal B (1 mumol/L versus 10 mumol/L, P < .05). salvianolic acid B 165-170 transforming growth factor beta 1 Homo sapiens 44-53 24669910-11 2014 These data demonstrate that Sal B inhibits TGF-beta1-induced cell proliferation and differentiation in vitro experiment. salvianolic acid B 28-33 transforming growth factor beta 1 Homo sapiens 43-52 24462865-2 2014 The present study was designed to investigate the effect of SalB on angiotensin II (AngII)-induced hypertrophy in neonatal rat cardiomyocytes, and to find out whether or not this effect is attributed to inhibition of poly (ADP-ribose) polymerase-1 (PARP-1), which plays a key role in cardiac hypertrophy. salvianolic acid B 60-64 angiotensinogen Rattus norvegicus 84-89 24462865-6 2014 In addition, SalB reversed the depletion of cellular NAD(+) induced by AngII. salvianolic acid B 13-17 angiotensinogen Rattus norvegicus 71-76 24462865-9 2014 Moreover, SalB attenuated the generation of oxidative stress via suppression of NADPH oxidase 2 and 4, which might probably contribute to the inhibition of PARP-1. salvianolic acid B 10-14 cytochrome b-245 beta chain Rattus norvegicus 80-101 24462865-9 2014 Moreover, SalB attenuated the generation of oxidative stress via suppression of NADPH oxidase 2 and 4, which might probably contribute to the inhibition of PARP-1. salvianolic acid B 10-14 poly (ADP-ribose) polymerase 1 Rattus norvegicus 156-162 24816457-3 2014 Here we describe a less expensive compound that may serve as a LIF substitute-salvianolic acid B (Sal B), a Salvia miltiorrhiza extract. salvianolic acid B 78-96 LIF interleukin 6 family cytokine Homo sapiens 63-66 24934350-0 2014 Salvianolic acid B inhibits atherogenesis of vascular cells through induction of Nrf2-dependent heme oxygenase-1. salvianolic acid B 0-18 heme oxygenase 1 Homo sapiens 96-112 24934350-4 2014 METHODS AND RESULTS: Treatment of vascular smooth muscle cells with Sal B effectively inhibited platelet-derived growth factor (PDGF)-induced cell proliferation and migration, and markedly increased heme oxygenase-1 (HO-1) expression. salvianolic acid B 68-73 heme oxygenase 1 Homo sapiens 199-215 24934350-4 2014 METHODS AND RESULTS: Treatment of vascular smooth muscle cells with Sal B effectively inhibited platelet-derived growth factor (PDGF)-induced cell proliferation and migration, and markedly increased heme oxygenase-1 (HO-1) expression. salvianolic acid B 68-73 heme oxygenase 1 Homo sapiens 217-221 24934350-7 2014 Knockdown of HO-1 expression by siRNA abolished the effects of Sal B in vascular cells and prevented the inhibition of proliferation, migration, and inflammation in HO-1-deficient cells. salvianolic acid B 63-68 heme oxygenase 1 Homo sapiens 13-17 24934350-9 2014 CONCLUSIONS: We conclude that Sal B exerts antiatherogenic effects by inhibiting the proliferation, migration, and inflammation of vascular cells through induction of HO-1 via Nrf2 activation. salvianolic acid B 30-35 heme oxygenase 1 Homo sapiens 167-171 24934350-9 2014 CONCLUSIONS: We conclude that Sal B exerts antiatherogenic effects by inhibiting the proliferation, migration, and inflammation of vascular cells through induction of HO-1 via Nrf2 activation. salvianolic acid B 30-35 NFE2 like bZIP transcription factor 2 Homo sapiens 176-180 23707207-9 2013 And the salvianolic acid B (6 muM, 48 muM), caffeic acid (6 muM, 48 muM) and rosmarinic acid (48 muM) could obviously inhibit LX-2 cells proliferation, down-regulate alpha-SMA expression. salvianolic acid B 8-26 latexin Homo sapiens 30-33 23943397-11 2013 The expression of pro-inflammatory factors TNF-alpha and NF-kappaB was found to be greatly increased 24 h post-SCI, and this upregulation was significantly attenuated by Sal B treatment. salvianolic acid B 170-175 tumor necrosis factor Rattus norvegicus 43-52 23943397-12 2013 The expression of ZO-1 and occludin was upregulated by Sal B (10 mg/kg) treatment after SCI, and this effect was blocked by the HO-1 inhibitor ZnPP. salvianolic acid B 55-60 tight junction protein 1 Rattus norvegicus 18-22 23943397-12 2013 The expression of ZO-1 and occludin was upregulated by Sal B (10 mg/kg) treatment after SCI, and this effect was blocked by the HO-1 inhibitor ZnPP. salvianolic acid B 55-60 occludin Rattus norvegicus 27-35 23943397-12 2013 The expression of ZO-1 and occludin was upregulated by Sal B (10 mg/kg) treatment after SCI, and this effect was blocked by the HO-1 inhibitor ZnPP. salvianolic acid B 55-60 heme oxygenase 1 Rattus norvegicus 128-132 23842993-0 2013 Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation. salvianolic acid B 0-18 mitogen-activated protein kinase 14 Homo sapiens 71-74 23842993-6 2013 Moreover, blocking p38 activation by specific inhibitor SB203580 or p38 specific siRNA partly reversed the anti-proliferative and pro-apoptotic effects, and ROS production induced by SalB treatment. salvianolic acid B 183-187 mitogen-activated protein kinase 14 Homo sapiens 19-22 23842993-6 2013 Moreover, blocking p38 activation by specific inhibitor SB203580 or p38 specific siRNA partly reversed the anti-proliferative and pro-apoptotic effects, and ROS production induced by SalB treatment. salvianolic acid B 183-187 mitogen-activated protein kinase 14 Homo sapiens 68-71 23842993-8 2013 All of these findings extended the anti-cancer effect of SalB in human glioma cell lines, and suggested that these inhibitory effects of SalB on U87 glioma cell growth might be associated with p38 activation mediated ROS generation. salvianolic acid B 137-141 mitogen-activated protein kinase 14 Homo sapiens 193-196 23764464-0 2013 SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. salvianolic acid B 32-50 Janus kinase 2 Rattus norvegicus 121-125 23764464-0 2013 SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. salvianolic acid B 32-50 signal transducer and activator of transcription 3 Rattus norvegicus 126-131 24006304-3 2013 In this study, we further investigated the mechanisms of Sal B on liver fibrosis relating to TGF-beta/Smads signalling pathway, especially to TGF-beta1 receptors. salvianolic acid B 57-62 transforming growth factor, beta 1 Rattus norvegicus 93-101 24006304-3 2013 In this study, we further investigated the mechanisms of Sal B on liver fibrosis relating to TGF-beta/Smads signalling pathway, especially to TGF-beta1 receptors. salvianolic acid B 57-62 transforming growth factor, beta 1 Rattus norvegicus 142-151 24006304-14 2013 The results showed that Sal B could inhibit collagen deposition and reduce Hyp content significantly, and decrease expressions of TGF-beta1 and TbetaR-I in fibrotic liver in vivo. salvianolic acid B 24-29 transforming growth factor, beta 1 Rattus norvegicus 130-139 24006304-14 2013 The results showed that Sal B could inhibit collagen deposition and reduce Hyp content significantly, and decrease expressions of TGF-beta1 and TbetaR-I in fibrotic liver in vivo. salvianolic acid B 24-29 transforming growth factor, beta receptor 1 Rattus norvegicus 144-152 24006304-16 2013 These findings suggested that Sal B could prevent HSCs activation through TGF-beta signalling pathway, i.e. inhibiting TGF-beta1 expression, activity of TbetaR-I kinase and Smads phosphorylation. salvianolic acid B 30-35 transforming growth factor, beta 1 Rattus norvegicus 74-82 24006304-16 2013 These findings suggested that Sal B could prevent HSCs activation through TGF-beta signalling pathway, i.e. inhibiting TGF-beta1 expression, activity of TbetaR-I kinase and Smads phosphorylation. salvianolic acid B 30-35 transforming growth factor, beta 1 Rattus norvegicus 119-128 24006304-16 2013 These findings suggested that Sal B could prevent HSCs activation through TGF-beta signalling pathway, i.e. inhibiting TGF-beta1 expression, activity of TbetaR-I kinase and Smads phosphorylation. salvianolic acid B 30-35 transforming growth factor, beta receptor 1 Rattus norvegicus 153-161 23707207-9 2013 And the salvianolic acid B (6 muM, 48 muM), caffeic acid (6 muM, 48 muM) and rosmarinic acid (48 muM) could obviously inhibit LX-2 cells proliferation, down-regulate alpha-SMA expression. salvianolic acid B 8-26 latexin Homo sapiens 38-41 23707207-9 2013 And the salvianolic acid B (6 muM, 48 muM), caffeic acid (6 muM, 48 muM) and rosmarinic acid (48 muM) could obviously inhibit LX-2 cells proliferation, down-regulate alpha-SMA expression. salvianolic acid B 8-26 latexin Homo sapiens 38-41 23707207-9 2013 And the salvianolic acid B (6 muM, 48 muM), caffeic acid (6 muM, 48 muM) and rosmarinic acid (48 muM) could obviously inhibit LX-2 cells proliferation, down-regulate alpha-SMA expression. salvianolic acid B 8-26 latexin Homo sapiens 38-41 23707207-9 2013 And the salvianolic acid B (6 muM, 48 muM), caffeic acid (6 muM, 48 muM) and rosmarinic acid (48 muM) could obviously inhibit LX-2 cells proliferation, down-regulate alpha-SMA expression. salvianolic acid B 8-26 latexin Homo sapiens 38-41 23461850-7 2013 Furthermore, SalB administration significantly rescued the Abeta25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels. salvianolic acid B 13-17 choline acetyltransferase Mus musculus 98-123 23461850-7 2013 Furthermore, SalB administration significantly rescued the Abeta25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels. salvianolic acid B 13-17 brain derived neurotrophic factor Mus musculus 128-161 22876447-7 2012 SalB was found to inhibit the reduction in MMP and decrease the activation of caspase-3. salvianolic acid B 0-4 caspase 3 Rattus norvegicus 78-87 23201927-5 2013 With MTT cell viability assay, LDH release, ROS generation, caspase-3 activity assay and Hoechst 33342/PI staining, we found that Sal B pretreatment provided significantly protection against ATO-induced cell death. salvianolic acid B 130-135 caspase 3 Rattus norvegicus 60-69 23201927-7 2013 Conversely, blocking Akt activation with the PI3K inhibitor LY294002 effectively suppressed the protective effect of Sal B against ATO-induced cell apoptosis. salvianolic acid B 117-122 AKT serine/threonine kinase 1 Homo sapiens 21-24 23201927-8 2013 In addition, the PI3K inhibitor partially blocked the effects of Sal B on the upregulation of Bcl-2 and Bcl-xl protein expression, and downregulation of Bax protein expression. salvianolic acid B 65-70 BCL2, apoptosis regulator Rattus norvegicus 94-99 23201927-8 2013 In addition, the PI3K inhibitor partially blocked the effects of Sal B on the upregulation of Bcl-2 and Bcl-xl protein expression, and downregulation of Bax protein expression. salvianolic acid B 65-70 Bcl2-like 1 Rattus norvegicus 104-110 22986787-11 2012 Although Sal B reduced ET-1-induced intracellular Ca(2+) increase, blocking Ca(2+) increase completely by BAPTA-AM, a Ca(2+) chelator, barely affected the magnitude of contraction. salvianolic acid B 9-14 endothelin 1 Rattus norvegicus 23-27 22442118-0 2012 Salvianolic acid B exerts vasoprotective effects through the modulation of heme oxygenase-1 and arginase activities. salvianolic acid B 0-18 heme oxygenase 1 Mus musculus 75-91 22442118-5 2012 Danshen and Sal B both induced the expression of heme oxygenase-1 (HO-1) and inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-activated RAW 264.7 cells. salvianolic acid B 12-17 heme oxygenase 1 Mus musculus 49-65 22442118-5 2012 Danshen and Sal B both induced the expression of heme oxygenase-1 (HO-1) and inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-activated RAW 264.7 cells. salvianolic acid B 12-17 heme oxygenase 1 Mus musculus 67-71 22442118-5 2012 Danshen and Sal B both induced the expression of heme oxygenase-1 (HO-1) and inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-activated RAW 264.7 cells. salvianolic acid B 12-17 nitric oxide synthase 2, inducible Mus musculus 120-141 22442118-5 2012 Danshen and Sal B both induced the expression of heme oxygenase-1 (HO-1) and inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-activated RAW 264.7 cells. salvianolic acid B 12-17 nitric oxide synthase 2, inducible Mus musculus 143-147 22442118-9 2012 These data suggest that HO-1 expression plays an intermediary role in the anti-inflammatory effects of Sal B. salvianolic acid B 103-108 heme oxygenase 1 Mus musculus 24-28 23041223-0 2012 Inhibitory effects of salvianolic acid B on CCl(4)-induced hepatic fibrosis through regulating NF-kappaB/IkappaBalpha signaling. salvianolic acid B 22-40 NFKB inhibitor alpha Rattus norvegicus 105-117 23041223-2 2012 Salvianolic acid B (SA-B) is one of water soluble compounds derived from Salvia miltiorrhiza Bunge (Danshen in Chinese) widely used for chronic liver diseases. salvianolic acid B 0-18 SH3-domain binding protein 5 Rattus norvegicus 20-24 23085027-3 2012 Sal B induced brain-derived neurotrophic factor (BDNF) production by BM-NSCs, which may be beneficial for the cells survival and differentiation in unfavourable environment. salvianolic acid B 0-5 brain derived neurotrophic factor Homo sapiens 14-47 23085027-3 2012 Sal B induced brain-derived neurotrophic factor (BDNF) production by BM-NSCs, which may be beneficial for the cells survival and differentiation in unfavourable environment. salvianolic acid B 0-5 brain derived neurotrophic factor Homo sapiens 49-53 22658257-2 2012 Through a high-throughput screening (HTS) assay for CD36 antagonist, we previously identified salvianolic acid B (SAB), a hydrophilic component derived from the herb Danshen, as a potential candidate. salvianolic acid B 94-112 SH3 domain binding protein 5 Homo sapiens 114-117 22876447-8 2012 CONCLUSION: 0.1, 1 and 10 mg/L of SalB inhibits activation of caspase-3 and early apoptosis of rat BMSCs induced by hypoxia/SD and could therefore enhance the survival rate of grafted stem cells. salvianolic acid B 34-38 caspase 3 Rattus norvegicus 62-71 21899995-2 2012 The ethanolic extract of Danshen roots (containing mainly tanshinones) inhibited CYP1A2-catalyzed phenacetin O-deethylation (IC(50)=24.6 mug/ml) in primary rat hepatocytes while the water extract containing mainly salvianolic acid B and danshenshu had no effect. salvianolic acid B 214-232 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 81-87 22252725-5 2012 Furthermore, Sal B down-regulated the HG-mediated Bax expression and AIF nuclear translocation and the release of cytochrome c, but up-regulated the HG-induced BcL-2 expression in SCs. salvianolic acid B 13-18 BCL2 associated X, apoptosis regulator Homo sapiens 50-53 22252725-5 2012 Furthermore, Sal B down-regulated the HG-mediated Bax expression and AIF nuclear translocation and the release of cytochrome c, but up-regulated the HG-induced BcL-2 expression in SCs. salvianolic acid B 13-18 cytochrome c, somatic Homo sapiens 114-126 22252725-5 2012 Furthermore, Sal B down-regulated the HG-mediated Bax expression and AIF nuclear translocation and the release of cytochrome c, but up-regulated the HG-induced BcL-2 expression in SCs. salvianolic acid B 13-18 BCL2 apoptosis regulator Homo sapiens 160-165 22252725-6 2012 In addition, Sal B attenuated the HG-induced activation of caspase 3 and 9 and minimized the cleavage of PARP in SCs. salvianolic acid B 13-18 collagen type XI alpha 2 chain Homo sapiens 105-109 22568239-5 2012 Meanwhile, Sal B has an effect on significantly reducing the expression of inhibit glutamate-induced active Caspase-3 protein, inhibiting accumulated glutamate-induced ROS and decreasing PC12 cell apoptosis rate within the range from 50 micromol x L(-1) to 200 micromol x L(-1). salvianolic acid B 11-16 caspase 3 Rattus norvegicus 108-117 22568239-6 2012 CONCLUSION: The study proves that Sal B prevented against glutamate-induced cell injury via inhibiting ROS formation and Caspase-3 pathway-dependent apoptosis in PC12 cells. salvianolic acid B 34-39 caspase 3 Rattus norvegicus 121-130 22036624-8 2012 Furthermore, treatment with Sal B down-regulated the IHG-induced release of cytochrome c, AIF nuclear translocation and Bax expression, but mitigated the IHG-mediated down-regulation of BcL-2 expression in SCs. salvianolic acid B 28-33 cytochrome c, somatic Homo sapiens 76-88 22036624-8 2012 Furthermore, treatment with Sal B down-regulated the IHG-induced release of cytochrome c, AIF nuclear translocation and Bax expression, but mitigated the IHG-mediated down-regulation of BcL-2 expression in SCs. salvianolic acid B 28-33 BCL2 associated X, apoptosis regulator Homo sapiens 120-123 22036624-8 2012 Furthermore, treatment with Sal B down-regulated the IHG-induced release of cytochrome c, AIF nuclear translocation and Bax expression, but mitigated the IHG-mediated down-regulation of BcL-2 expression in SCs. salvianolic acid B 28-33 BCL2 apoptosis regulator Homo sapiens 186-191 22036624-9 2012 In addition, treatment with Sal B attenuated the IHG-induced activation of caspase-9 and caspase-3 and minimized the cleavage of PARP in SCs. salvianolic acid B 28-33 caspase 9 Homo sapiens 75-84 22036624-9 2012 In addition, treatment with Sal B attenuated the IHG-induced activation of caspase-9 and caspase-3 and minimized the cleavage of PARP in SCs. salvianolic acid B 28-33 caspase 3 Homo sapiens 89-98 22036624-9 2012 In addition, treatment with Sal B attenuated the IHG-induced activation of caspase-9 and caspase-3 and minimized the cleavage of PARP in SCs. salvianolic acid B 28-33 collagen type XI alpha 2 chain Homo sapiens 129-133 21899995-6 2012 A formulated Danshen pill (containing mainly danshensu and salvianolic acid B and the tanshinones) up-regulated CYP1A2 protein expression and enzyme activity, but danshensu and salvianolic acid B, when used individually, did not affect CYP1A2 activity. salvianolic acid B 59-77 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 112-118 23243430-0 2012 Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling. salvianolic acid B 0-18 angiotensinogen Rattus norvegicus 70-84 23243430-2 2012 Salvianolic acid B (Sal B), one of the water-soluble components from Radix Salviae miltiorrhizae, has been used to treat hepatic fibrosis, but it is still not clear whether the effect of Sal B is related to angiotensin II (Ang II) signaling pathway. salvianolic acid B 0-18 angiotensinogen Rattus norvegicus 207-221 23243430-5 2012 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B 0-5 angiotensinogen Rattus norvegicus 34-40 23243430-2 2012 Salvianolic acid B (Sal B), one of the water-soluble components from Radix Salviae miltiorrhizae, has been used to treat hepatic fibrosis, but it is still not clear whether the effect of Sal B is related to angiotensin II (Ang II) signaling pathway. salvianolic acid B 0-18 angiotensinogen Rattus norvegicus 223-229 23243430-5 2012 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B 0-5 actin gamma 2, smooth muscle Rattus norvegicus 144-169 23243430-2 2012 Salvianolic acid B (Sal B), one of the water-soluble components from Radix Salviae miltiorrhizae, has been used to treat hepatic fibrosis, but it is still not clear whether the effect of Sal B is related to angiotensin II (Ang II) signaling pathway. salvianolic acid B 20-25 angiotensinogen Rattus norvegicus 207-221 23243430-5 2012 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B 0-5 actin gamma 2, smooth muscle Rattus norvegicus 171-180 23243430-2 2012 Salvianolic acid B (Sal B), one of the water-soluble components from Radix Salviae miltiorrhizae, has been used to treat hepatic fibrosis, but it is still not clear whether the effect of Sal B is related to angiotensin II (Ang II) signaling pathway. salvianolic acid B 20-25 angiotensinogen Rattus norvegicus 223-229 23243430-5 2012 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B 0-5 transforming growth factor, beta 1 Rattus norvegicus 267-275 23243430-3 2012 In the present study, we studied Sal B effect on rat liver fibrosis and Ang-II related signaling mediators in dimethylnitrosamine-(DMN-) induced rat fibrotic model in vivo and Ang-II stimulated hepatic stellate cells (HSCs) in vitro, with perindopril or losartan as control drug, respectively. salvianolic acid B 33-38 angiotensinogen Rattus norvegicus 176-182 23243430-5 2012 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B 0-5 angiotensin II receptor, type 1a Rattus norvegicus 296-300 23243430-4 2012 The results showed that Sal B and perindopril inhibited rat hepatic fibrosis and reduced expression of Ang II receptor type 1 (AT1R) and ERK activation in fibrotic liver. salvianolic acid B 24-29 angiotensinogen Rattus norvegicus 103-109 23243430-5 2012 Sal B and losartan also inhibited Ang II-stimulated HSC activation including cell proliferation and expression of type I collagen I (Col-I) and alpha-smooth muscle actin (alpha-SMA) production in vitro, reduced the gene expression of transforming growth factor beta (TGF-beta), and downregulated AT1R expression and ERK and c-Jun phosphorylation. salvianolic acid B 0-5 Eph receptor B1 Rattus norvegicus 316-319 23243430-4 2012 The results showed that Sal B and perindopril inhibited rat hepatic fibrosis and reduced expression of Ang II receptor type 1 (AT1R) and ERK activation in fibrotic liver. salvianolic acid B 24-29 angiotensin II receptor, type 1a Rattus norvegicus 127-131 23243430-6 2012 In conclusion, our results indicate that Sal B may exert an antihepatic fibrosis effect via downregulating Ang II signaling in HSC activation. salvianolic acid B 41-46 angiotensinogen Rattus norvegicus 107-113 23243430-4 2012 The results showed that Sal B and perindopril inhibited rat hepatic fibrosis and reduced expression of Ang II receptor type 1 (AT1R) and ERK activation in fibrotic liver. salvianolic acid B 24-29 Eph receptor B1 Rattus norvegicus 137-140 21649636-8 2011 Knocking down PPARgamma with the corresponding siRNA blocked these effects of Sal B. salvianolic acid B 78-83 peroxisome proliferator activated receptor gamma Homo sapiens 14-23 22545124-8 2012 Western Blotting results showed that stimulation of NSPCs with Sal B enhanced the phosphorylation of Akt, and Ly294002 abolished this effect, confirming the role of Akt in Sal B mediated proliferation of NSPCs. salvianolic acid B 63-68 AKT serine/threonine kinase 1 Rattus norvegicus 101-104 22545124-8 2012 Western Blotting results showed that stimulation of NSPCs with Sal B enhanced the phosphorylation of Akt, and Ly294002 abolished this effect, confirming the role of Akt in Sal B mediated proliferation of NSPCs. salvianolic acid B 172-177 AKT serine/threonine kinase 1 Rattus norvegicus 165-168 22545124-12 2012 SIGNIFICANCE: Sal B could maintain the NSPCs self-renew and promote proliferation, which was mediated by PI3K/Akt signal pathway. salvianolic acid B 14-19 AKT serine/threonine kinase 1 Rattus norvegicus 110-113 21860657-0 2012 Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-beta1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways. salvianolic acid B 0-18 mitogen-activated protein kinase 14 Homo sapiens 36-39 21860657-0 2012 Salvianolic Acid B Inhibits ERK and p38 MAPK Signaling in TGF-beta1-Stimulated Human Hepatic Stellate Cell Line (LX-2) via Distinct Pathways. salvianolic acid B 0-18 transforming growth factor beta 1 Homo sapiens 58-67 21860657-1 2012 Salvianolic acid B (SA-B) is water-soluble component of Radix Salvia miltiorrhiza. salvianolic acid B 0-18 SH3 domain binding protein 5 Homo sapiens 20-24 22166584-0 2012 Salvianolic acid B inhibits SDF-1alpha-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor. salvianolic acid B 0-18 C-X-C motif chemokine receptor 4 Homo sapiens 130-135 22166584-1 2012 Salvianolic acid B (Sal B), a bioactive compound from Salvia miltiorrhiza, widely used to treat cardiovascular diseases, and stromal cell-derived factor-1alpha (SDF-1alpha)/CXCR4 pathway has been correlated with balloon angioplasty-induced neointimal formation. salvianolic acid B 0-18 C-X-C motif chemokine receptor 4 Homo sapiens 173-178 22166584-1 2012 Salvianolic acid B (Sal B), a bioactive compound from Salvia miltiorrhiza, widely used to treat cardiovascular diseases, and stromal cell-derived factor-1alpha (SDF-1alpha)/CXCR4 pathway has been correlated with balloon angioplasty-induced neointimal formation. salvianolic acid B 20-25 C-X-C motif chemokine receptor 4 Homo sapiens 173-178 22166584-2 2012 The purposes of the present study were to investigate whether Sal B can inhibit SDF-1alpha/CXCR4-mediated effects on the cell proliferation and migration of vascular smooth muscle cells (VSMCs) and to examine its possible molecular mechanisms. salvianolic acid B 62-67 C-X-C motif chemokine receptor 4 Homo sapiens 91-96 21649636-0 2011 Salvianolic acid B suppresses maturation of human monocyte-derived dendritic cells by activating PPARgamma. salvianolic acid B 0-18 peroxisome proliferator activated receptor gamma Homo sapiens 97-106 21649636-9 2011 CONCLUSIONS AND IMPLICATIONS: Our data suggested that Sal B effectively suppressed maturation of h-monDC induced by ox-LDL through PPARgamma activation. salvianolic acid B 54-59 peroxisome proliferator activated receptor gamma Homo sapiens 131-140 22101700-0 2011 Salvianolic acid B inhibits the TLR4-NFkappaB-TNFalpha pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide. salvianolic acid B 0-18 toll-like receptor 4 Rattus norvegicus 32-36 21782496-0 2011 Investigation of the binding of Salvianolic acid B to human serum albumin and the effect of metal ions on the binding. salvianolic acid B 32-50 albumin Homo sapiens 60-73 21782496-3 2011 In this study, the interaction of Salvianolic acid B (Sal B) with human serum albumin (HSA) was investigated by the steady-state, synchronous fluorescence and circular dichroism (CD) spectroscopies. salvianolic acid B 34-52 albumin Homo sapiens 72-85 21992896-0 2011 Salvianolic acid B suppresses IFN-gamma-induced JAK/STAT1 activation in endothelial cells. salvianolic acid B 0-18 interferon gamma Homo sapiens 30-39 21992896-0 2011 Salvianolic acid B suppresses IFN-gamma-induced JAK/STAT1 activation in endothelial cells. salvianolic acid B 0-18 signal transducer and activator of transcription 1 Homo sapiens 52-57 21992896-3 2011 METHODS AND RESULTS: Sal B pretreatment significantly inhibited the IFN-gamma-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). salvianolic acid B 21-26 interferon gamma Homo sapiens 68-77 21992896-3 2011 METHODS AND RESULTS: Sal B pretreatment significantly inhibited the IFN-gamma-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). salvianolic acid B 21-26 Janus kinase 2 Homo sapiens 106-110 21992896-3 2011 METHODS AND RESULTS: Sal B pretreatment significantly inhibited the IFN-gamma-induced phosphorylations of JAK2 (Tyr 1007/1008) and STAT1 (Tyr701 and Ser727). salvianolic acid B 21-26 signal transducer and activator of transcription 1 Homo sapiens 131-136 21992896-4 2011 Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines" IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. salvianolic acid B 114-119 interferon gamma Homo sapiens 14-23 21992896-4 2011 Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines" IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. salvianolic acid B 114-119 signal transducer and activator of transcription 1 Homo sapiens 32-37 21992896-4 2011 Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines" IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. salvianolic acid B 114-119 C-X-C motif chemokine ligand 10 Homo sapiens 73-78 21992896-4 2011 Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines" IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. salvianolic acid B 114-119 C-X-C motif chemokine ligand 9 Homo sapiens 80-83 21992896-4 2011 Consistently, IFN-gamma-induced STAT1 downstream targets CXC chemokines" IP-10, Mig, and I-TAC were suppressed by Sal B pretreatment. salvianolic acid B 114-119 C-X-C motif chemokine ligand 11 Homo sapiens 89-94 21992896-5 2011 Sal B inhibited promoter activities of IP-10 and the secretion of IP-10 protein. salvianolic acid B 0-5 C-X-C motif chemokine ligand 10 Homo sapiens 39-44 21992896-5 2011 Sal B inhibited promoter activities of IP-10 and the secretion of IP-10 protein. salvianolic acid B 0-5 C-X-C motif chemokine ligand 10 Homo sapiens 66-71 21992896-6 2011 The monocyte adhesion to IFN-gamma-treated ECs was observed to be reduced after Sal B pretreatment. salvianolic acid B 80-85 interferon gamma Homo sapiens 25-34 21992896-7 2011 ECs treated with Sal B alone also increased the expression of PIAS1 and SOCS1 which may also contribute to its inhibitory effect on JAK-STAT1 signaling pathways. salvianolic acid B 17-22 protein inhibitor of activated STAT 1 Homo sapiens 62-67 21992896-7 2011 ECs treated with Sal B alone also increased the expression of PIAS1 and SOCS1 which may also contribute to its inhibitory effect on JAK-STAT1 signaling pathways. salvianolic acid B 17-22 suppressor of cytokine signaling 1 Homo sapiens 72-77 21992896-7 2011 ECs treated with Sal B alone also increased the expression of PIAS1 and SOCS1 which may also contribute to its inhibitory effect on JAK-STAT1 signaling pathways. salvianolic acid B 17-22 signal transducer and activator of transcription 1 Homo sapiens 136-141 21992896-8 2011 CONCLUSIONS: The anti-inflammatory properties of Sal B on IFN-gamma-induced JAK-STAT1 activation were demonstrated in the present study which provides a molecular basis for possible therapeutic usage on vascular disorders. salvianolic acid B 49-54 interferon gamma Homo sapiens 58-67 21992896-8 2011 CONCLUSIONS: The anti-inflammatory properties of Sal B on IFN-gamma-induced JAK-STAT1 activation were demonstrated in the present study which provides a molecular basis for possible therapeutic usage on vascular disorders. salvianolic acid B 49-54 signal transducer and activator of transcription 1 Homo sapiens 80-85 22101700-18 2011 The protective effects of Sal B may be through inhibiting the TLR4-NFkappaB-TNFalpha pathway and are dose-dependent. salvianolic acid B 26-31 toll-like receptor 4 Rattus norvegicus 62-66 22101700-18 2011 The protective effects of Sal B may be through inhibiting the TLR4-NFkappaB-TNFalpha pathway and are dose-dependent. salvianolic acid B 26-31 tumor necrosis factor Rattus norvegicus 76-84 22101700-0 2011 Salvianolic acid B inhibits the TLR4-NFkappaB-TNFalpha pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide. salvianolic acid B 0-18 tumor necrosis factor Rattus norvegicus 46-54 22101700-1 2011 OBJECTIVE: To investigate the role of the TLR4-NFkappaB-TNFalpha inflammation pathway on: lipopolysaccharide (LPS)-induced neonatal rat cardiomyocyte injury and the possible protective effects of salvianolic acid B (Sal B). salvianolic acid B 196-214 toll-like receptor 4 Rattus norvegicus 42-46 22101700-1 2011 OBJECTIVE: To investigate the role of the TLR4-NFkappaB-TNFalpha inflammation pathway on: lipopolysaccharide (LPS)-induced neonatal rat cardiomyocyte injury and the possible protective effects of salvianolic acid B (Sal B). salvianolic acid B 216-221 toll-like receptor 4 Rattus norvegicus 42-46 22101700-10 2011 Compared with the LPS control group, the concentrations of LDH and TNFalpha were significantly decreased in the Sal B 10(-5)mol/L pre-treated group (451.76+-83.96 U/L and 34.00+-10.38 pg/mL, respectively, P<0.05). salvianolic acid B 112-117 tumor necrosis factor Rattus norvegicus 67-75 21365754-9 2011 The signal network was certified by measuring the binding affinity of SB to EGFR in vitro, the effect of SB on internalization and phosphorylation of EGFR, the effect of SB on viability and proliferation of H9C2 cells, and the expression of inner membrane mitochondrial protein in the presence of EGFR inhibitor AG 1478. salvianolic acid B 70-72 epidermal growth factor receptor Rattus norvegicus 76-80 21947724-5 2011 This study was designed to investigate the effects of salvianolic acid B (Sal B), a pure compound extracted from Radix Salviae Miltiorrhizae, a Chinese herb, on cell proliferation and CYP1A2 and CYP3A4 mRNA expression in the presence or absence of rifampicin, a potent inducer of CYPs and GST protein expression in HepG2 cells. salvianolic acid B 54-72 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 184-190 21947724-5 2011 This study was designed to investigate the effects of salvianolic acid B (Sal B), a pure compound extracted from Radix Salviae Miltiorrhizae, a Chinese herb, on cell proliferation and CYP1A2 and CYP3A4 mRNA expression in the presence or absence of rifampicin, a potent inducer of CYPs and GST protein expression in HepG2 cells. salvianolic acid B 54-72 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 195-201 21947724-5 2011 This study was designed to investigate the effects of salvianolic acid B (Sal B), a pure compound extracted from Radix Salviae Miltiorrhizae, a Chinese herb, on cell proliferation and CYP1A2 and CYP3A4 mRNA expression in the presence or absence of rifampicin, a potent inducer of CYPs and GST protein expression in HepG2 cells. salvianolic acid B 74-79 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 184-190 21947724-5 2011 This study was designed to investigate the effects of salvianolic acid B (Sal B), a pure compound extracted from Radix Salviae Miltiorrhizae, a Chinese herb, on cell proliferation and CYP1A2 and CYP3A4 mRNA expression in the presence or absence of rifampicin, a potent inducer of CYPs and GST protein expression in HepG2 cells. salvianolic acid B 74-79 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 195-201 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 12-17 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 53-59 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 12-17 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 64-70 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 12-17 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-174 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 12-17 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-174 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 147-152 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-174 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 147-152 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-174 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 147-152 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-174 21947724-11 2011 Ten mumol/L Sal B, but not 1 mumol/L, down-regulated CYP3A4 and CYP1A2 mRNA expression after 24 hours of incubation, whereas both 1 and 10 mumol/L Sal B down-regulated CYP3A4 mRNA expression after 96 hours of incubation; moreover, 1 and 10 mumol/L Sal B inhibited CYP3A4 mRNA expression induced by rifampicin. salvianolic acid B 147-152 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-174 21947724-13 2011 CONCLUSION: Sal B inhibits CYP3A4 and CYP1A2 mRNA expression and induces GST expression in HepG2 cells. salvianolic acid B 12-17 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 27-33 21947724-13 2011 CONCLUSION: Sal B inhibits CYP3A4 and CYP1A2 mRNA expression and induces GST expression in HepG2 cells. salvianolic acid B 12-17 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 38-44 21733125-2 2011 In this study, it was found that salvianolic acid B (SaB), lithospermic acid (LA), and rosmarinic acid (RA), three main hydrophilic constituents in Danshen, conjugated with glutathione (GSH) easily in vitro but exhibited no NQO1-inducing activities in Hepa 1c1c7 cells, which might attribute to their poor absorptions. salvianolic acid B 33-51 NAD(P)H dehydrogenase, quinone 1 Mus musculus 224-228 21733125-2 2011 In this study, it was found that salvianolic acid B (SaB), lithospermic acid (LA), and rosmarinic acid (RA), three main hydrophilic constituents in Danshen, conjugated with glutathione (GSH) easily in vitro but exhibited no NQO1-inducing activities in Hepa 1c1c7 cells, which might attribute to their poor absorptions. salvianolic acid B 53-56 NAD(P)H dehydrogenase, quinone 1 Mus musculus 224-228 21726465-3 2011 METHODS: Two well-characterized oral squamous cell carcinoma cell lines, CAL27 and SCC4, and premalignant leukoplakia cells were treated with different concentrations of Sal B. salvianolic acid B 170-175 MAU2 sister chromatid cohesion factor Homo sapiens 83-87 21365754-9 2011 The signal network was certified by measuring the binding affinity of SB to EGFR in vitro, the effect of SB on internalization and phosphorylation of EGFR, the effect of SB on viability and proliferation of H9C2 cells, and the expression of inner membrane mitochondrial protein in the presence of EGFR inhibitor AG 1478. salvianolic acid B 105-107 epidermal growth factor receptor Rattus norvegicus 150-154 21365754-9 2011 The signal network was certified by measuring the binding affinity of SB to EGFR in vitro, the effect of SB on internalization and phosphorylation of EGFR, the effect of SB on viability and proliferation of H9C2 cells, and the expression of inner membrane mitochondrial protein in the presence of EGFR inhibitor AG 1478. salvianolic acid B 105-107 epidermal growth factor receptor Rattus norvegicus 150-154 21117944-5 2011 The PXR mRNA expression in LS174T cells was significantly induced by physcion, protocatechuic aldehyde, salvianolic acid B, and sodium danshensu. salvianolic acid B 104-122 nuclear receptor subfamily 1 group I member 2 Homo sapiens 4-7 21547681-2 2011 Here we investigated the ability reversal of Sal B to reverse the transdifferentiation of human kidney proximal tubular epithelial cells that was induced by transforming growth factor-beta 1 (TGF-beta1). salvianolic acid B 45-50 transforming growth factor beta 1 Homo sapiens 157-190 21608231-0 2011 [Effect of salvianolic acid B on CD14 expression in rats with liver fibrosis]. salvianolic acid B 11-29 CD14 molecule Rattus norvegicus 33-37 21608231-1 2011 OBJECTIVE: To observe the effect of salvianolic acid B (SAB), an extract from Radix Salviae miltiorrhizae, on expression of leucocyte differentiation antigen 14 (CD14) in the liver tissue of experimental rats with carbon tetrachloride (CCl4)-induced liver fibrosis. salvianolic acid B 36-54 CD14 molecule Rattus norvegicus 162-166 21608231-1 2011 OBJECTIVE: To observe the effect of salvianolic acid B (SAB), an extract from Radix Salviae miltiorrhizae, on expression of leucocyte differentiation antigen 14 (CD14) in the liver tissue of experimental rats with carbon tetrachloride (CCl4)-induced liver fibrosis. salvianolic acid B 36-54 C-C motif chemokine ligand 4 Rattus norvegicus 236-240 21608231-1 2011 OBJECTIVE: To observe the effect of salvianolic acid B (SAB), an extract from Radix Salviae miltiorrhizae, on expression of leucocyte differentiation antigen 14 (CD14) in the liver tissue of experimental rats with carbon tetrachloride (CCl4)-induced liver fibrosis. salvianolic acid B 56-59 CD14 molecule Rattus norvegicus 162-166 21608231-1 2011 OBJECTIVE: To observe the effect of salvianolic acid B (SAB), an extract from Radix Salviae miltiorrhizae, on expression of leucocyte differentiation antigen 14 (CD14) in the liver tissue of experimental rats with carbon tetrachloride (CCl4)-induced liver fibrosis. salvianolic acid B 56-59 C-C motif chemokine ligand 4 Rattus norvegicus 236-240 21608231-9 2011 CONCLUSIONS: SAB could antagonize the CCl4, induced liver fibrosis in rats. salvianolic acid B 13-16 C-C motif chemokine ligand 4 Rattus norvegicus 38-42 21547681-2 2011 Here we investigated the ability reversal of Sal B to reverse the transdifferentiation of human kidney proximal tubular epithelial cells that was induced by transforming growth factor-beta 1 (TGF-beta1). salvianolic acid B 45-50 transforming growth factor beta 1 Homo sapiens 192-201 20238162-2 2010 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B 24-29 tumor necrosis factor Rattus norvegicus 89-116 21379382-6 2011 Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hsp70), LIM domain protein CLP-36, copine I, peroxiredoxin-2, coronin-1 B and cytoplasmic dynein intermediate chain 2C. salvianolic acid B 13-15 heat shock protein family A (Hsp70) member 2 Rattus norvegicus 57-92 21379382-6 2011 Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hsp70), LIM domain protein CLP-36, copine I, peroxiredoxin-2, coronin-1 B and cytoplasmic dynein intermediate chain 2C. salvianolic acid B 13-15 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 94-99 21379382-6 2011 Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hsp70), LIM domain protein CLP-36, copine I, peroxiredoxin-2, coronin-1 B and cytoplasmic dynein intermediate chain 2C. salvianolic acid B 13-15 PDZ and LIM domain 1 Rattus norvegicus 121-127 21379382-6 2011 Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hsp70), LIM domain protein CLP-36, copine I, peroxiredoxin-2, coronin-1 B and cytoplasmic dynein intermediate chain 2C. salvianolic acid B 13-15 copine 1 Rattus norvegicus 129-137 21379382-6 2011 Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hsp70), LIM domain protein CLP-36, copine I, peroxiredoxin-2, coronin-1 B and cytoplasmic dynein intermediate chain 2C. salvianolic acid B 13-15 peroxiredoxin 2 Rattus norvegicus 139-154 21379382-6 2011 Treatment of SB caused regulation of 20 proteins such as heat shock-related 70 kDa protein 2 (hsp70), LIM domain protein CLP-36, copine I, peroxiredoxin-2, coronin-1 B and cytoplasmic dynein intermediate chain 2C. salvianolic acid B 13-15 coronin 1B Rattus norvegicus 156-167 21379382-13 2011 The signal cascades network of SB after binding with integrin alpha2beta1 might include regulation of intracellular Ca2+ level, cytoskeleton-related proteins such as coronin-1B and cytoskeleton structure of platelets. salvianolic acid B 31-33 coronin 1B Rattus norvegicus 166-176 21113177-6 2011 Sal B (50 mumol/L) inhibited the increase in LC3-II, reduced the abundance of LC3 immunofluorescence and intensity of Caspase-8 fluorescence, and enhanced cellular viability and ATP levels in myocytes under GD 3 h, regardless of whether chloroquine was present. salvianolic acid B 0-5 microtubule associated protein 1 light chain 3 alpha Homo sapiens 45-48 21113177-6 2011 Sal B (50 mumol/L) inhibited the increase in LC3-II, reduced the abundance of LC3 immunofluorescence and intensity of Caspase-8 fluorescence, and enhanced cellular viability and ATP levels in myocytes under GD 3 h, regardless of whether chloroquine was present. salvianolic acid B 0-5 microtubule associated protein 1 light chain 3 alpha Homo sapiens 78-81 21113177-6 2011 Sal B (50 mumol/L) inhibited the increase in LC3-II, reduced the abundance of LC3 immunofluorescence and intensity of Caspase-8 fluorescence, and enhanced cellular viability and ATP levels in myocytes under GD 3 h, regardless of whether chloroquine was present. salvianolic acid B 0-5 caspase 8 Homo sapiens 118-127 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 vimentin Homo sapiens 75-83 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 prolyl 4-hydroxylase subunit beta Homo sapiens 106-133 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 heat shock protein family B (small) member 1 Homo sapiens 154-179 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 UBX domain protein 6 Homo sapiens 181-212 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 enolase 1 Homo sapiens 214-227 21423689-5 2011 Proteins that showed increased expression levels upon Sal B treatment were vimentin, T-complex protein 1, protein disulfide isomerase, tropomyosin alpha, heat shock protein beta-1, UBX domain-containing protein 1, alpha enolase, and peroxiredoxin-2. salvianolic acid B 54-59 peroxiredoxin 2 Homo sapiens 233-248 20238162-4 2010 Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1beta mRNA expression, which was accompanied by inhibiting transcription factor NF-kappaB activation. salvianolic acid B 0-5 nitric oxide synthase 2 Rattus norvegicus 34-65 20238162-4 2010 Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1beta mRNA expression, which was accompanied by inhibiting transcription factor NF-kappaB activation. salvianolic acid B 0-5 nitric oxide synthase 2 Rattus norvegicus 67-71 20238162-4 2010 Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1beta mRNA expression, which was accompanied by inhibiting transcription factor NF-kappaB activation. salvianolic acid B 0-5 tumor necrosis factor Rattus norvegicus 74-83 20238162-4 2010 Sal B also suppressed LPS-induced inducible nitric oxide synthase (iNOS), TNF-alpha, and IL-1beta mRNA expression, which was accompanied by inhibiting transcription factor NF-kappaB activation. salvianolic acid B 0-5 interleukin 1 beta Rattus norvegicus 89-97 20629637-0 2010 MEK/ERK pathway mediates cytoprotection of salvianolic acid B against oxidative stress-induced apoptosis in rat bone marrow stem cells. salvianolic acid B 43-61 Eph receptor B1 Rattus norvegicus 4-7 21348308-3 2010 Following the identification by HPLC-MS/MS, peak 2, 3, 4, and 5 were rosmaric acid, lithospermic acid, salvianolic acid B, and salvianolic acid A, respectively, which also confirmed with reference standards of those components. salvianolic acid B 103-121 PEAK1 related, kinase-activating pseudokinase 1 Homo sapiens 44-50 20735854-0 2010 Salvianolic acid B functioned as a competitive inhibitor of matrix metalloproteinase-9 and efficiently prevented cardiac remodeling. salvianolic acid B 0-18 matrix metallopeptidase 9 Rattus norvegicus 60-86 20735854-3 2010 Salvianolic acid B (SalB) from Salviae mitiorrhizae, which has been widely used in China for the treatment of cardiovascular diseases, is a potential candidate for therapeutic intervention of LV remodeling targeting matrix metalloproteinase-9 (MMP-9). salvianolic acid B 0-18 matrix metallopeptidase 9 Rattus norvegicus 216-242 20735854-3 2010 Salvianolic acid B (SalB) from Salviae mitiorrhizae, which has been widely used in China for the treatment of cardiovascular diseases, is a potential candidate for therapeutic intervention of LV remodeling targeting matrix metalloproteinase-9 (MMP-9). salvianolic acid B 0-18 matrix metallopeptidase 9 Rattus norvegicus 244-249 20735854-3 2010 Salvianolic acid B (SalB) from Salviae mitiorrhizae, which has been widely used in China for the treatment of cardiovascular diseases, is a potential candidate for therapeutic intervention of LV remodeling targeting matrix metalloproteinase-9 (MMP-9). salvianolic acid B 20-24 matrix metallopeptidase 9 Rattus norvegicus 216-242 20735854-3 2010 Salvianolic acid B (SalB) from Salviae mitiorrhizae, which has been widely used in China for the treatment of cardiovascular diseases, is a potential candidate for therapeutic intervention of LV remodeling targeting matrix metalloproteinase-9 (MMP-9). salvianolic acid B 20-24 matrix metallopeptidase 9 Rattus norvegicus 244-249 20238162-2 2010 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B 24-29 tumor necrosis factor Rattus norvegicus 118-127 20238162-2 2010 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B 24-29 interleukin 1 beta Rattus norvegicus 130-147 20238162-2 2010 Our results showed that Sal B significantly reduced the production of nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) and reactive oxygen species (ROS) induced by lipopolysaccharide (LPS) treatment in rat primary microglia in a dose-dependent manner. salvianolic acid B 24-29 interleukin 1 beta Rattus norvegicus 149-157 20602267-7 2010 The mRNA for tau, GFAP and nestin were present in differentiating neurospheres induced by salvianolic acid B. salvianolic acid B 90-108 glial fibrillary acidic protein Mus musculus 18-22 20501859-5 2010 We found that salvianolic acid B (Sal-B), isolated from Salvia miltiorrhiza Bge, can effectively suppress COX-2 expression and induce apoptosis in a variety of cancer cell lines. salvianolic acid B 14-32 cox2 Salvia miltiorrhiza 106-111 20501859-5 2010 We found that salvianolic acid B (Sal-B), isolated from Salvia miltiorrhiza Bge, can effectively suppress COX-2 expression and induce apoptosis in a variety of cancer cell lines. salvianolic acid B 34-39 cox2 Salvia miltiorrhiza 106-111 20441599-0 2010 Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro. salvianolic acid B 0-18 transforming growth factor, beta 1 Rattus norvegicus 77-86 20441599-4 2010 The aims of the study are to investigate the effect of Sal B on tubular EMT in vivo and in vitro, and to elucidate its underlying mechanism against EMT related to TGF-beta1/Smads pathway. salvianolic acid B 55-60 transforming growth factor, beta 1 Rattus norvegicus 163-172 20441599-7 2010 In contrast, Sal B and vitamin E significantly attenuated the expression of alpha-SMA, TGF-beta1, TbetaR-I, p-Smad2/3, and MMP-2 activity, but increased E-cadherin expression. salvianolic acid B 13-18 transforming growth factor, beta 1 Rattus norvegicus 87-96 20441599-7 2010 In contrast, Sal B and vitamin E significantly attenuated the expression of alpha-SMA, TGF-beta1, TbetaR-I, p-Smad2/3, and MMP-2 activity, but increased E-cadherin expression. salvianolic acid B 13-18 transforming growth factor, beta receptor 1 Rattus norvegicus 98-106 20441599-7 2010 In contrast, Sal B and vitamin E significantly attenuated the expression of alpha-SMA, TGF-beta1, TbetaR-I, p-Smad2/3, and MMP-2 activity, but increased E-cadherin expression. salvianolic acid B 13-18 SMAD family member 3 Rattus norvegicus 110-117 20441599-7 2010 In contrast, Sal B and vitamin E significantly attenuated the expression of alpha-SMA, TGF-beta1, TbetaR-I, p-Smad2/3, and MMP-2 activity, but increased E-cadherin expression. salvianolic acid B 13-18 matrix metallopeptidase 2 Rattus norvegicus 123-128 20441599-7 2010 In contrast, Sal B and vitamin E significantly attenuated the expression of alpha-SMA, TGF-beta1, TbetaR-I, p-Smad2/3, and MMP-2 activity, but increased E-cadherin expression. salvianolic acid B 13-18 cadherin 1 Rattus norvegicus 153-163 20441599-9 2010 TGF-beta1 induced a typical EMT in HK-2 cells, while it was blocked by Sal B and SB-431542, as evidenced by blocking morphologic transformation, restoring E-cadherin and CK-18 expression, inhibiting alpha-SMA expression and F-actin reorganization, and down-regulating MMP-2/9 activities in TGF-beta1 mediated HK-2 cells. salvianolic acid B 71-76 transforming growth factor, beta 1 Rattus norvegicus 0-9 20441599-9 2010 TGF-beta1 induced a typical EMT in HK-2 cells, while it was blocked by Sal B and SB-431542, as evidenced by blocking morphologic transformation, restoring E-cadherin and CK-18 expression, inhibiting alpha-SMA expression and F-actin reorganization, and down-regulating MMP-2/9 activities in TGF-beta1 mediated HK-2 cells. salvianolic acid B 71-76 cadherin 1 Rattus norvegicus 155-165 20441599-9 2010 TGF-beta1 induced a typical EMT in HK-2 cells, while it was blocked by Sal B and SB-431542, as evidenced by blocking morphologic transformation, restoring E-cadherin and CK-18 expression, inhibiting alpha-SMA expression and F-actin reorganization, and down-regulating MMP-2/9 activities in TGF-beta1 mediated HK-2 cells. salvianolic acid B 71-76 keratin 18 Rattus norvegicus 170-175 20441599-9 2010 TGF-beta1 induced a typical EMT in HK-2 cells, while it was blocked by Sal B and SB-431542, as evidenced by blocking morphologic transformation, restoring E-cadherin and CK-18 expression, inhibiting alpha-SMA expression and F-actin reorganization, and down-regulating MMP-2/9 activities in TGF-beta1 mediated HK-2 cells. salvianolic acid B 71-76 matrix metallopeptidase 2 Rattus norvegicus 268-273 20441599-9 2010 TGF-beta1 induced a typical EMT in HK-2 cells, while it was blocked by Sal B and SB-431542, as evidenced by blocking morphologic transformation, restoring E-cadherin and CK-18 expression, inhibiting alpha-SMA expression and F-actin reorganization, and down-regulating MMP-2/9 activities in TGF-beta1 mediated HK-2 cells. salvianolic acid B 71-76 transforming growth factor, beta 1 Rattus norvegicus 290-299 20349724-0 2010 [Impact of salvianolic acid-B on TGF-beta1-induced HK-2 epithelial-mesenchymal transition]. salvianolic acid B 11-29 transforming growth factor beta 1 Homo sapiens 33-42 20571239-0 2010 The effect of salvianolic acid B combined with laminar shear stress on TNF-alpha-stimulated adhesion molecule expression in human aortic endothelial cells. salvianolic acid B 14-32 tumor necrosis factor Homo sapiens 71-80 20571239-1 2010 The study was conducted to investigate the effect of Salvianolic acid B (Sal B) on TNF-alpha-stimulated adhesion molecule expression i.e. vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in human aortic endothelial cells (HAECs) under laminar shear stress (LSS) condition. salvianolic acid B 53-71 tumor necrosis factor Homo sapiens 83-92 20571239-1 2010 The study was conducted to investigate the effect of Salvianolic acid B (Sal B) on TNF-alpha-stimulated adhesion molecule expression i.e. vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in human aortic endothelial cells (HAECs) under laminar shear stress (LSS) condition. salvianolic acid B 73-78 tumor necrosis factor Homo sapiens 83-92 20571239-1 2010 The study was conducted to investigate the effect of Salvianolic acid B (Sal B) on TNF-alpha-stimulated adhesion molecule expression i.e. vascular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and E-selectin in human aortic endothelial cells (HAECs) under laminar shear stress (LSS) condition. salvianolic acid B 73-78 vascular cell adhesion molecule 1 Homo sapiens 138-166 20571239-3 2010 Pre-treatment of HAECs with Sal B (10 microg/ml) then exposed to LSS (12 dynes/cm(2)) for 6 h significantly inhibited VCAM-1, ICAM-1 and E-selectin expression stimulated by TNF-alpha. salvianolic acid B 28-33 vascular cell adhesion molecule 1 Homo sapiens 118-124 20571239-3 2010 Pre-treatment of HAECs with Sal B (10 microg/ml) then exposed to LSS (12 dynes/cm(2)) for 6 h significantly inhibited VCAM-1, ICAM-1 and E-selectin expression stimulated by TNF-alpha. salvianolic acid B 28-33 intercellular adhesion molecule 1 Homo sapiens 126-132 20571239-3 2010 Pre-treatment of HAECs with Sal B (10 microg/ml) then exposed to LSS (12 dynes/cm(2)) for 6 h significantly inhibited VCAM-1, ICAM-1 and E-selectin expression stimulated by TNF-alpha. salvianolic acid B 28-33 selectin E Homo sapiens 137-147 20571239-3 2010 Pre-treatment of HAECs with Sal B (10 microg/ml) then exposed to LSS (12 dynes/cm(2)) for 6 h significantly inhibited VCAM-1, ICAM-1 and E-selectin expression stimulated by TNF-alpha. salvianolic acid B 28-33 tumor necrosis factor Homo sapiens 173-182